id	sid	tid	token	lemma	pos
ajst-10978	1	1	academic	academic	ADJ
ajst-10978	1	2	journal	journal	NOUN
ajst-10978	1	3	of	of	ADP
ajst-10978	1	4	science	science	NOUN
ajst-10978	1	5	and	and	CCONJ
ajst-10978	1	6	technology	technology	NOUN
ajst-10978	1	7	issn	issn	NOUN
ajst-10978	1	8	:	:	PUNCT
ajst-10978	1	9	2771	2771	NUM
ajst-10978	1	10	-	-	SYM
ajst-10978	1	11	3032	3032	NUM
ajst-10978	1	12	|	|	NOUN
ajst-10978	1	13	vol	vol	NOUN
ajst-10978	1	14	.	.	PROPN
ajst-10978	2	1	7	7	NUM
ajst-10978	2	2	,	,	PUNCT
ajst-10978	2	3	no	no	INTJ
ajst-10978	2	4	.	.	NOUN
ajst-10978	2	5	1	1	NUM
ajst-10978	2	6	,	,	PUNCT
ajst-10978	2	7	2023	2023	NUM
ajst-10978	2	8	5	5	NUM
ajst-10978	2	9	expression	expression	NOUN
ajst-10978	2	10	patterns	pattern	NOUN
ajst-10978	2	11	of	of	ADP
ajst-10978	2	12	immune	immune	ADJ
ajst-10978	2	13	checkpoints	checkpoint	NOUN
ajst-10978	2	14	in	in	ADP
ajst-10978	2	15	breast	breast	NOUN
ajst-10978	2	16	cancer	cancer	NOUN
ajst-10978	2	17	patients	patient	NOUN
ajst-10978	2	18	ruirui	ruirui	PROPN
ajst-10978	2	19	ma1	ma1	PROPN
ajst-10978	2	20	,	,	PUNCT
ajst-10978	2	21	xinyi	xinyi	PROPN
ajst-10978	2	22	ma2	ma2	PROPN
ajst-10978	2	23	,	,	PUNCT
ajst-10978	2	24	xianxin	xianxin	PROPN
ajst-10978	2	25	yan1	yan1	PROPN
ajst-10978	2	26	,	,	PUNCT
ajst-10978	2	27	min	min	PROPN
ajst-10978	2	28	ma1	ma1	PROPN
ajst-10978	2	29	,	,	PUNCT
ajst-10978	2	30	*	*	PROPN
ajst-10978	2	31	1jinan	1jinan	NUM
ajst-10978	2	32	university	university	NOUN
ajst-10978	2	33	,	,	PUNCT
ajst-10978	2	34	no.601	no.601	ADV
ajst-10978	2	35	,	,	PUNCT
ajst-10978	2	36	west	west	PROPN
ajst-10978	2	37	huangpu	huangpu	PROPN
ajst-10978	2	38	avenue	avenue	PROPN
ajst-10978	2	39	,	,	PUNCT
ajst-10978	2	40	guangzhou	guangzhou	PROPN
ajst-10978	2	41	,	,	PUNCT
ajst-10978	2	42	510632	510632	NUM
ajst-10978	2	43	,	,	PUNCT
ajst-10978	2	44	guangdong	guangdong	PROPN
ajst-10978	2	45	,	,	PUNCT
ajst-10978	2	46	china	china	PROPN
ajst-10978	2	47	2the	2the	NUM
ajst-10978	2	48	first	first	ADJ
ajst-10978	2	49	clinical	clinical	ADJ
ajst-10978	2	50	medical	medical	ADJ
ajst-10978	2	51	college	college	PROPN
ajst-10978	2	52	of	of	ADP
ajst-10978	2	53	southern	southern	PROPN
ajst-10978	2	54	medical	medical	PROPN
ajst-10978	2	55	university	university	PROPN
ajst-10978	2	56	,	,	PUNCT
ajst-10978	2	57	guangzhou	guangzhou	PROPN
ajst-10978	2	58	,	,	PUNCT
ajst-10978	2	59	510515	510515	NUM
ajst-10978	2	60	,	,	PUNCT
ajst-10978	2	61	guangdong	guangdong	PROPN
ajst-10978	2	62	,	,	PUNCT
ajst-10978	2	63	china	china	PROPN
ajst-10978	2	64	*	*	PUNCT
ajst-10978	2	65	corresponding	correspond	VERB
ajst-10978	2	66	author	author	NOUN
ajst-10978	2	67	abstract	abstract	NOUN
ajst-10978	2	68	:	:	PUNCT
ajst-10978	2	69	background	background	NOUN
ajst-10978	2	70	:	:	PUNCT
ajst-10978	2	71	immunotherapy	immunotherapy	NOUN
ajst-10978	2	72	with	with	ADP
ajst-10978	2	73	immune	immune	ADJ
ajst-10978	2	74	checkpoint	checkpoint	NOUN
ajst-10978	2	75	inhibitors	inhibitor	NOUN
ajst-10978	2	76	(	(	PUNCT
ajst-10978	2	77	icis	icis	PROPN
ajst-10978	2	78	)	)	PUNCT
ajst-10978	2	79	for	for	ADP
ajst-10978	2	80	solid	solid	ADJ
ajst-10978	2	81	tumors	tumor	NOUN
ajst-10978	2	82	had	have	AUX
ajst-10978	2	83	significantly	significantly	ADV
ajst-10978	2	84	improved	improve	VERB
ajst-10978	2	85	overall	overall	ADJ
ajst-10978	2	86	survival	survival	NOUN
ajst-10978	2	87	(	(	PUNCT
ajst-10978	2	88	os	os	NOUN
ajst-10978	2	89	)	)	PUNCT
ajst-10978	2	90	.	.	PUNCT
ajst-10978	3	1	positive	positive	ADJ
ajst-10978	3	2	response	response	NOUN
ajst-10978	3	3	to	to	ADP
ajst-10978	3	4	pd-1	pd-1	ADP
ajst-10978	3	5	/	/	SYM
ajst-10978	3	6	pd	pd	ADJ
ajst-10978	3	7	-	-	PUNCT
ajst-10978	3	8	l1	l1	PROPN
ajst-10978	3	9	blockades	blockade	NOUN
ajst-10978	3	10	was	be	AUX
ajst-10978	3	11	observed	observe	VERB
ajst-10978	3	12	in	in	ADP
ajst-10978	3	13	the	the	DET
ajst-10978	3	14	treatment	treatment	NOUN
ajst-10978	3	15	of	of	ADP
ajst-10978	3	16	solid	solid	ADJ
ajst-10978	3	17	tumors	tumor	NOUN
ajst-10978	3	18	.	.	PUNCT
ajst-10978	4	1	breast	breast	NOUN
ajst-10978	4	2	cancer	cancer	NOUN
ajst-10978	4	3	(	(	PUNCT
ajst-10978	4	4	bc	bc	PROPN
ajst-10978	4	5	)	)	PUNCT
ajst-10978	4	6	patients	patient	NOUN
ajst-10978	4	7	are	be	AUX
ajst-10978	4	8	no	no	DET
ajst-10978	4	9	exception	exception	NOUN
ajst-10978	4	10	.	.	PUNCT
ajst-10978	5	1	however	however	ADV
ajst-10978	5	2	,	,	PUNCT
ajst-10978	5	3	the	the	DET
ajst-10978	5	4	efficacy	efficacy	NOUN
ajst-10978	5	5	of	of	ADP
ajst-10978	5	6	immunocheckpoint	immunocheckpoint	NOUN
ajst-10978	5	7	therapy	therapy	NOUN
ajst-10978	5	8	in	in	ADP
ajst-10978	5	9	bc	bc	PROPN
ajst-10978	5	10	patients	patient	NOUN
ajst-10978	5	11	remains	remain	VERB
ajst-10978	5	12	poor	poor	ADJ
ajst-10978	5	13	.	.	PUNCT
ajst-10978	6	1	a	a	DET
ajst-10978	6	2	particularly	particularly	ADV
ajst-10978	6	3	important	important	ADJ
ajst-10978	6	4	factor	factor	NOUN
ajst-10978	6	5	is	be	AUX
ajst-10978	6	6	the	the	DET
ajst-10978	6	7	lack	lack	NOUN
ajst-10978	6	8	of	of	ADP
ajst-10978	6	9	studies	study	NOUN
ajst-10978	6	10	on	on	ADP
ajst-10978	6	11	the	the	DET
ajst-10978	6	12	expression	expression	NOUN
ajst-10978	6	13	patterns	pattern	NOUN
ajst-10978	6	14	of	of	ADP
ajst-10978	6	15	immune	immune	ADJ
ajst-10978	6	16	checkpoints	checkpoint	NOUN
ajst-10978	6	17	in	in	ADP
ajst-10978	6	18	bc	bc	PROPN
ajst-10978	6	19	patients	patient	NOUN
ajst-10978	6	20	.	.	PUNCT
ajst-10978	7	1	methods：this	methods：this	PRON
ajst-10978	7	2	article	article	NOUN
ajst-10978	7	3	summarizes	summarize	VERB
ajst-10978	7	4	the	the	DET
ajst-10978	7	5	expression	expression	NOUN
ajst-10978	7	6	of	of	ADP
ajst-10978	7	7	immune	immune	ADJ
ajst-10978	7	8	checkpoints	checkpoint	NOUN
ajst-10978	7	9	such	such	ADJ
ajst-10978	7	10	as	as	ADP
ajst-10978	7	11	pd-1	pd-1	ADJ
ajst-10978	7	12	,	,	PUNCT
ajst-10978	7	13	pd	pd	PROPN
ajst-10978	7	14	-	-	PUNCT
ajst-10978	7	15	l1	l1	PROPN
ajst-10978	7	16	,	,	PUNCT
ajst-10978	7	17	stat1	stat1	PROPN
ajst-10978	7	18	,	,	PUNCT
ajst-10978	7	19	ctla-4	ctla-4	NOUN
ajst-10978	7	20	in	in	ADP
ajst-10978	7	21	bc	bc	PROPN
ajst-10978	7	22	,	,	PUNCT
ajst-10978	7	23	and	and	CCONJ
ajst-10978	7	24	analyzes	analyze	VERB
ajst-10978	7	25	the	the	DET
ajst-10978	7	26	relationship	relationship	NOUN
ajst-10978	7	27	between	between	ADP
ajst-10978	7	28	the	the	DET
ajst-10978	7	29	expression	expression	NOUN
ajst-10978	7	30	of	of	ADP
ajst-10978	7	31	these	these	DET
ajst-10978	7	32	immune	immune	ADJ
ajst-10978	7	33	checkpoints	checkpoint	NOUN
ajst-10978	7	34	and	and	CCONJ
ajst-10978	7	35	os.results	os.result	NOUN
ajst-10978	7	36	:	:	PUNCT
ajst-10978	7	37	it	it	PRON
ajst-10978	7	38	was	be	AUX
ajst-10978	7	39	found	find	VERB
ajst-10978	7	40	that	that	SCONJ
ajst-10978	7	41	increased	increase	VERB
ajst-10978	7	42	expression	expression	NOUN
ajst-10978	7	43	of	of	ADP
ajst-10978	7	44	pd-1	pd-1	ADP
ajst-10978	7	45	,	,	PUNCT
ajst-10978	7	46	pd	pd	PROPN
ajst-10978	7	47	-	-	PUNCT
ajst-10978	7	48	l1	l1	PROPN
ajst-10978	7	49	,	,	PUNCT
ajst-10978	7	50	stat1	stat1	PROPN
ajst-10978	7	51	,	,	PUNCT
ajst-10978	7	52	ctla-4	ctla-4	NUM
ajst-10978	7	53	was	be	AUX
ajst-10978	7	54	associated	associate	VERB
ajst-10978	7	55	with	with	ADP
ajst-10978	7	56	poor	poor	ADJ
ajst-10978	7	57	os	os	NOUN
ajst-10978	7	58	in	in	ADP
ajst-10978	7	59	bc	bc	PROPN
ajst-10978	7	60	patients	patient	NOUN
ajst-10978	7	61	.	.	PUNCT
ajst-10978	8	1	in	in	ADP
ajst-10978	8	2	addition	addition	NOUN
ajst-10978	8	3	,	,	PUNCT
ajst-10978	8	4	co	co	NOUN
ajst-10978	8	5	-	-	NOUN
ajst-10978	8	6	expression	expression	NOUN
ajst-10978	8	7	of	of	ADP
ajst-10978	8	8	pd	pd	PROPN
ajst-10978	8	9	-	-	PROPN
ajst-10978	8	10	l1	l1	PROPN
ajst-10978	8	11	with	with	ADP
ajst-10978	8	12	pd-1	pd-1	ADP
ajst-10978	8	13	,	,	PUNCT
ajst-10978	8	14	stat1or	stat1or	PROPN
ajst-10978	8	15	ctla4	ctla4	NOUN
ajst-10978	8	16	and	and	CCONJ
ajst-10978	8	17	co	co	NOUN
ajst-10978	8	18	-	-	NOUN
ajst-10978	8	19	expression	expression	NOUN
ajst-10978	8	20	of	of	ADP
ajst-10978	8	21	pd-1	pd-1	ADJ
ajst-10978	8	22	with	with	ADP
ajst-10978	8	23	ctla-4was	ctla-4wa	VERB
ajst-10978	8	24	related	relate	VERB
ajst-10978	8	25	to	to	ADP
ajst-10978	8	26	poor	poor	ADJ
ajst-10978	8	27	os	os	NOUN
ajst-10978	8	28	.	.	PUNCT
ajst-10978	9	1	we	we	PRON
ajst-10978	9	2	analyzed	analyze	VERB
ajst-10978	9	3	associations	association	NOUN
ajst-10978	9	4	between	between	ADP
ajst-10978	9	5	the	the	DET
ajst-10978	9	6	proportionate	proportionate	ADJ
ajst-10978	9	7	expression	expression	NOUN
ajst-10978	9	8	of	of	ADP
ajst-10978	9	9	pd	pd	PROPN
ajst-10978	9	10	-	-	PROPN
ajst-10978	9	11	l1	l1	PROPN
ajst-10978	9	12	and	and	CCONJ
ajst-10978	9	13	pd-1	pd-1	ADV
ajst-10978	9	14	,	,	PUNCT
ajst-10978	9	15	pd	pd	PROPN
ajst-10978	9	16	-	-	PROPN
ajst-10978	9	17	l1	l1	PROPN
ajst-10978	9	18	and	and	CCONJ
ajst-10978	9	19	stat1	stat1	PROPN
ajst-10978	9	20	,	,	PUNCT
ajst-10978	9	21	pd-1	pd-1	ADJ
ajst-10978	9	22	and	and	CCONJ
ajst-10978	9	23	ctla-4	ctla-4	NUM
ajst-10978	9	24	,	,	PUNCT
ajst-10978	9	25	pd-1	pd-1	ADJ
ajst-10978	9	26	and	and	CCONJ
ajst-10978	9	27	lag3	lag3	PROPN
ajst-10978	9	28	,	,	PUNCT
ajst-10978	9	29	pd	pd	PROPN
ajst-10978	9	30	-	-	PROPN
ajst-10978	9	31	l1	l1	PROPN
ajst-10978	9	32	and	and	CCONJ
ajst-10978	9	33	ctla-4	ctla-4	NOUN
ajst-10978	9	34	in	in	ADP
ajst-10978	9	35	bc	bc	PROPN
ajst-10978	9	36	patients	patient	NOUN
ajst-10978	9	37	,	,	PUNCT
ajst-10978	9	38	there	there	PRON
ajst-10978	9	39	was	be	VERB
ajst-10978	9	40	significance	significance	NOUN
ajst-10978	9	41	in	in	ADP
ajst-10978	9	42	correlation	correlation	NOUN
ajst-10978	9	43	in	in	ADP
ajst-10978	9	44	both	both	PRON
ajst-10978	9	45	of	of	ADP
ajst-10978	9	46	the	the	DET
ajst-10978	9	47	bc	bc	PROPN
ajst-10978	9	48	patients	patient	NOUN
ajst-10978	9	49	.	.	PUNCT
ajst-10978	10	1	conclusions	conclusion	NOUN
ajst-10978	10	2	:	:	PUNCT
ajst-10978	10	3	our	our	PRON
ajst-10978	10	4	results	result	NOUN
ajst-10978	10	5	suggest	suggest	VERB
ajst-10978	10	6	that	that	SCONJ
ajst-10978	10	7	transcriptome	transcriptome	NOUN
ajst-10978	10	8	-	-	PUNCT
ajst-10978	10	9	based	base	VERB
ajst-10978	10	10	coexpression	coexpression	NOUN
ajst-10978	10	11	of	of	ADP
ajst-10978	10	12	stat1	stat1	PROPN
ajst-10978	10	13	and	and	CCONJ
ajst-10978	10	14	pd	pd	PROPN
ajst-10978	10	15	-	-	PROPN
ajst-10978	10	16	l1	l1	PROPN
ajst-10978	10	17	is	be	AUX
ajst-10978	10	18	a	a	DET
ajst-10978	10	19	predictor	predictor	NOUN
ajst-10978	10	20	for	for	ADP
ajst-10978	10	21	poor	poor	ADJ
ajst-10978	10	22	os	os	NOUN
ajst-10978	10	23	in	in	ADP
ajst-10978	10	24	bc	bc	PROPN
ajst-10978	10	25	patients	patient	NOUN
ajst-10978	10	26	,	,	PUNCT
ajst-10978	10	27	which	which	PRON
ajst-10978	10	28	might	might	AUX
ajst-10978	10	29	provide	provide	VERB
ajst-10978	10	30	novel	novel	ADJ
ajst-10978	10	31	insight	insight	NOUN
ajst-10978	10	32	into	into	ADP
ajst-10978	10	33	designing	design	VERB
ajst-10978	10	34	combinational	combinational	ADJ
ajst-10978	10	35	targeted	target	VERB
ajst-10978	10	36	therapy	therapy	NOUN
ajst-10978	10	37	for	for	ADP
ajst-10978	10	38	bc	bc	PROPN
ajst-10978	10	39	.	.	PUNCT
ajst-10978	11	1	keywords	keyword	NOUN
ajst-10978	11	2	:	:	PUNCT
ajst-10978	11	3	pd	pd	PROPN
ajst-10978	11	4	-	-	PUNCT
ajst-10978	11	5	l1	l1	PROPN
ajst-10978	11	6	,	,	PUNCT
ajst-10978	11	7	pd-1	pd-1	ADV
ajst-10978	11	8	,	,	PUNCT
ajst-10978	11	9	stat1	stat1	ADJ
ajst-10978	11	10	,	,	PUNCT
ajst-10978	11	11	immune	immune	ADJ
ajst-10978	11	12	checkpoint	checkpoint	NOUN
ajst-10978	11	13	,	,	PUNCT
ajst-10978	11	14	breast	breast	NOUN
ajst-10978	11	15	cancer	cancer	NOUN
ajst-10978	11	16	.	.	PUNCT
ajst-10978	12	1	1	1	X
ajst-10978	12	2	.	.	X
ajst-10978	12	3	background	background	NOUN
ajst-10978	12	4	over	over	ADP
ajst-10978	12	5	the	the	DET
ajst-10978	12	6	past	past	ADJ
ajst-10978	12	7	5	5	NUM
ajst-10978	12	8	years	year	NOUN
ajst-10978	12	9	,	,	PUNCT
ajst-10978	12	10	immunotherapy	immunotherapy	NOUN
ajst-10978	12	11	with	with	ADP
ajst-10978	12	12	immune	immune	ADJ
ajst-10978	12	13	checkpoint	checkpoint	NOUN
ajst-10978	12	14	inhibitors	inhibitor	NOUN
ajst-10978	12	15	has	have	AUX
ajst-10978	12	16	revolutionized	revolutionize	VERB
ajst-10978	12	17	the	the	DET
ajst-10978	12	18	management	management	NOUN
ajst-10978	12	19	of	of	ADP
ajst-10978	12	20	various	various	ADJ
ajst-10978	12	21	cancers	cancer	NOUN
ajst-10978	12	22	[	[	X
ajst-10978	12	23	1	1	NUM
ajst-10978	12	24	]	]	PUNCT
ajst-10978	12	25	.	.	PUNCT
ajst-10978	13	1	the	the	DET
ajst-10978	13	2	occurrence	occurrence	NOUN
ajst-10978	13	3	and	and	CCONJ
ajst-10978	13	4	development	development	NOUN
ajst-10978	13	5	of	of	ADP
ajst-10978	13	6	cancer	cancer	NOUN
ajst-10978	13	7	is	be	AUX
ajst-10978	13	8	closely	closely	ADV
ajst-10978	13	9	related	relate	VERB
ajst-10978	13	10	to	to	ADP
ajst-10978	13	11	immune	immune	ADJ
ajst-10978	13	12	escape	escape	NOUN
ajst-10978	13	13	and	and	CCONJ
ajst-10978	13	14	abnormal	abnormal	ADJ
ajst-10978	13	15	immune	immune	ADJ
ajst-10978	13	16	monitoring	monitoring	NOUN
ajst-10978	13	17	.	.	PUNCT
ajst-10978	14	1	a	a	DET
ajst-10978	14	2	familiar	familiar	ADJ
ajst-10978	14	3	cell	cell	NOUN
ajst-10978	14	4	surface	surface	NOUN
ajst-10978	14	5	receptor	receptor	NOUN
ajst-10978	14	6	,	,	PUNCT
ajst-10978	14	7	called	call	VERB
ajst-10978	14	8	programmed	programmed	ADJ
ajst-10978	14	9	cell	cell	NOUN
ajst-10978	14	10	death	death	NOUN
ajst-10978	14	11	protein	protein	NOUN
ajst-10978	14	12	1	1	NUM
ajst-10978	14	13	(	(	PUNCT
ajst-10978	14	14	pd-1	pd-1	NOUN
ajst-10978	14	15	)	)	PUNCT
ajst-10978	14	16	,	,	PUNCT
ajst-10978	14	17	may	may	AUX
ajst-10978	14	18	allow	allow	VERB
ajst-10978	14	19	t	t	PROPN
ajst-10978	14	20	cells	cell	NOUN
ajst-10978	14	21	to	to	PART
ajst-10978	14	22	escape	escape	VERB
ajst-10978	14	23	anti	anti	ADJ
ajst-10978	14	24	-	-	ADJ
ajst-10978	14	25	tumor	tumor	ADJ
ajst-10978	14	26	immunity	immunity	NOUN
ajst-10978	14	27	when	when	SCONJ
ajst-10978	14	28	the	the	DET
ajst-10978	14	29	cells	cell	NOUN
ajst-10978	14	30	associated	associate	VERB
ajst-10978	14	31	with	with	ADP
ajst-10978	14	32	cancer	cancer	NOUN
ajst-10978	14	33	cells	cell	NOUN
ajst-10978	14	34	are	be	AUX
ajst-10978	14	35	upregulated	upregulate	VERB
ajst-10978	14	36	.	.	PUNCT
ajst-10978	15	1	ligand	ligand	NOUN
ajst-10978	15	2	for	for	ADP
ajst-10978	15	3	the	the	DET
ajst-10978	15	4	pd-1	pd-1	ADJ
ajst-10978	15	5	receptor	receptor	NOUN
ajst-10978	15	6	,	,	PUNCT
ajst-10978	15	7	programmed	program	VERB
ajst-10978	15	8	death	death	NOUN
ajst-10978	15	9	ligand	ligand	NOUN
ajst-10978	15	10	1	1	NUM
ajst-10978	15	11	(	(	PUNCT
ajst-10978	15	12	pd	pd	NOUN
ajst-10978	15	13	-	-	PUNCT
ajst-10978	15	14	l1	l1	PROPN
ajst-10978	15	15	)	)	PUNCT
ajst-10978	15	16	,	,	PUNCT
ajst-10978	15	17	is	be	AUX
ajst-10978	15	18	expressed	express	VERB
ajst-10978	15	19	in	in	ADP
ajst-10978	15	20	a	a	DET
ajst-10978	15	21	variety	variety	NOUN
ajst-10978	15	22	of	of	ADP
ajst-10978	15	23	epithelial	epithelial	ADJ
ajst-10978	15	24	cancers	cancer	NOUN
ajst-10978	15	25	[	[	X
ajst-10978	15	26	2	2	NUM
ajst-10978	15	27	]	]	PUNCT
ajst-10978	15	28	.	.	PUNCT
ajst-10978	16	1	in	in	ADP
ajst-10978	16	2	addition	addition	NOUN
ajst-10978	16	3	,	,	PUNCT
ajst-10978	16	4	other	other	ADJ
ajst-10978	16	5	immune	immune	ADJ
ajst-10978	16	6	checkpoint	checkpoint	NOUN
ajst-10978	16	7	molecules	molecule	NOUN
ajst-10978	16	8	such	such	ADJ
ajst-10978	16	9	as	as	ADP
ajst-10978	16	10	ctla-4	ctla-4	PROPN
ajst-10978	16	11	,	,	PUNCT
ajst-10978	16	12	lag3	lag3	PROPN
ajst-10978	16	13	,	,	PUNCT
ajst-10978	16	14	and	and	CCONJ
ajst-10978	16	15	fgl1	fgl1	PROPN
ajst-10978	16	16	have	have	AUX
ajst-10978	16	17	also	also	ADV
ajst-10978	16	18	been	be	AUX
ajst-10978	16	19	studied	study	VERB
ajst-10978	16	20	[	[	PUNCT
ajst-10978	16	21	3	3	NUM
ajst-10978	16	22	,	,	PUNCT
ajst-10978	16	23	4	4	NUM
ajst-10978	16	24	]	]	PUNCT
ajst-10978	16	25	.	.	PUNCT
ajst-10978	17	1	the	the	DET
ajst-10978	17	2	pd-1	pd-1	NOUN
ajst-10978	17	3	/	/	SYM
ajst-10978	17	4	pd	pd	NOUN
ajst-10978	17	5	-	-	PROPN
ajst-10978	17	6	l1	l1	PROPN
ajst-10978	17	7	signaling	signal	VERB
ajst-10978	17	8	pathway	pathway	NOUN
ajst-10978	17	9	mainly	mainly	ADV
ajst-10978	17	10	causes	cause	VERB
ajst-10978	17	11	the	the	DET
ajst-10978	17	12	body	body	NOUN
ajst-10978	17	13	to	to	PART
ajst-10978	17	14	be	be	AUX
ajst-10978	17	15	in	in	ADP
ajst-10978	17	16	the	the	DET
ajst-10978	17	17	state	state	NOUN
ajst-10978	17	18	of	of	ADP
ajst-10978	17	19	immunosuppression	immunosuppression	NOUN
ajst-10978	17	20	[	[	X
ajst-10978	17	21	5	5	NUM
ajst-10978	17	22	]	]	PUNCT
ajst-10978	17	23	.	.	PUNCT
ajst-10978	18	1	recently	recently	ADV
ajst-10978	18	2	,	,	PUNCT
ajst-10978	18	3	cancer	cancer	NOUN
ajst-10978	18	4	immunotherapy	immunotherapy	NOUN
ajst-10978	18	5	employing	employ	VERB
ajst-10978	18	6	pd-1	pd-1	ADP
ajst-10978	18	7	/	/	SYM
ajst-10978	18	8	pd	pd	ADJ
ajst-10978	18	9	-	-	PUNCT
ajst-10978	18	10	l1	l1	PROPN
ajst-10978	18	11	inhibitors	inhibitor	NOUN
ajst-10978	18	12	has	have	AUX
ajst-10978	18	13	resulted	result	VERB
ajst-10978	18	14	in	in	ADP
ajst-10978	18	15	drastic	drastic	ADJ
ajst-10978	18	16	improvements	improvement	NOUN
ajst-10978	18	17	in	in	ADP
ajst-10978	18	18	clinical	clinical	ADJ
ajst-10978	18	19	outcomes	outcome	NOUN
ajst-10978	18	20	in	in	ADP
ajst-10978	18	21	multiple	multiple	ADJ
ajst-10978	18	22	malignant	malignant	ADJ
ajst-10978	18	23	tumors	tumor	NOUN
ajst-10978	18	24	[	[	X
ajst-10978	18	25	6	6	NUM
ajst-10978	18	26	,	,	PUNCT
ajst-10978	18	27	7	7	NUM
ajst-10978	18	28	]	]	PUNCT
ajst-10978	18	29	.	.	PUNCT
ajst-10978	19	1	moreover	moreover	ADV
ajst-10978	19	2	,	,	PUNCT
ajst-10978	19	3	an	an	DET
ajst-10978	19	4	anti	anti	ADJ
ajst-10978	19	5	-	-	ADJ
ajst-10978	19	6	pd-1	pd-1	ADJ
ajst-10978	19	7	mab	mab	NOUN
ajst-10978	19	8	have	have	AUX
ajst-10978	19	9	shown	show	VERB
ajst-10978	19	10	good	good	ADJ
ajst-10978	19	11	safety	safety	NOUN
ajst-10978	19	12	to	to	PART
ajst-10978	19	13	multiline	multiline	VERB
ajst-10978	19	14	systemic	systemic	ADJ
ajst-10978	19	15	therapy	therapy	NOUN
ajst-10978	19	16	in	in	ADP
ajst-10978	19	17	patients	patient	NOUN
ajst-10978	19	18	with	with	ADP
ajst-10978	19	19	advanced	advanced	ADJ
ajst-10978	19	20	refractory	refractory	NOUN
ajst-10978	19	21	tnbc	tnbc	NOUN
ajst-10978	19	22	[	[	X
ajst-10978	19	23	8	8	NUM
ajst-10978	19	24	]	]	PUNCT
ajst-10978	19	25	.	.	PUNCT
ajst-10978	20	1	previous	previous	ADJ
ajst-10978	20	2	reports	report	NOUN
ajst-10978	20	3	have	have	AUX
ajst-10978	20	4	shown	show	VERB
ajst-10978	20	5	that	that	SCONJ
ajst-10978	20	6	pd-1	pd-1	ADP
ajst-10978	20	7	and	and	CCONJ
ajst-10978	20	8	pd	pd	PROPN
ajst-10978	20	9	-	-	PUNCT
ajst-10978	20	10	l1	l1	PROPN
ajst-10978	20	11	correlated	correlate	VERB
ajst-10978	20	12	gene	gene	NOUN
ajst-10978	20	13	expression	expression	NOUN
ajst-10978	20	14	profiles	profile	NOUN
ajst-10978	20	15	and	and	CCONJ
ajst-10978	20	16	their	their	PRON
ajst-10978	20	17	association	association	NOUN
ajst-10978	20	18	with	with	ADP
ajst-10978	20	19	clinical	clinical	ADJ
ajst-10978	20	20	outcomes	outcome	NOUN
ajst-10978	20	21	of	of	ADP
ajst-10978	20	22	bc	bc	PROPN
ajst-10978	21	1	[	[	X
ajst-10978	21	2	9	9	NUM
ajst-10978	21	3	]	]	PUNCT
ajst-10978	21	4	.	.	PUNCT
ajst-10978	22	1	in	in	ADP
ajst-10978	22	2	addition	addition	NOUN
ajst-10978	22	3	,	,	PUNCT
ajst-10978	22	4	pdl1	pdl1	NOUN
ajst-10978	22	5	expression	expression	NOUN
ajst-10978	22	6	is	be	AUX
ajst-10978	22	7	closely	closely	ADV
ajst-10978	22	8	related	relate	VERB
ajst-10978	22	9	to	to	ADP
ajst-10978	22	10	the	the	DET
ajst-10978	22	11	positive	positive	ADJ
ajst-10978	22	12	response	response	NOUN
ajst-10978	22	13	of	of	ADP
ajst-10978	22	14	pd-1	pd-1	ADP
ajst-10978	22	15	/	/	SYM
ajst-10978	22	16	pd	pd	ADJ
ajst-10978	22	17	-	-	PUNCT
ajst-10978	22	18	l1	l1	PROPN
ajst-10978	22	19	blockade	blockade	NOUN
ajst-10978	22	20	in	in	ADP
ajst-10978	22	21	solid	solid	ADJ
ajst-10978	22	22	tumor	tumor	NOUN
ajst-10978	22	23	therapy	therapy	NOUN
ajst-10978	22	24	[	[	X
ajst-10978	22	25	10	10	NUM
ajst-10978	22	26	]	]	PUNCT
ajst-10978	22	27	.	.	PUNCT
ajst-10978	23	1	these	these	DET
ajst-10978	23	2	findings	finding	NOUN
ajst-10978	23	3	suggest	suggest	VERB
ajst-10978	23	4	that	that	SCONJ
ajst-10978	23	5	pd-1	pd-1	ADP
ajst-10978	23	6	/	/	SYM
ajst-10978	23	7	pd	pd	ADJ
ajst-10978	23	8	-	-	PUNCT
ajst-10978	23	9	l1	l1	PROPN
ajst-10978	23	10	blockade	blockade	NOUN
ajst-10978	23	11	may	may	AUX
ajst-10978	23	12	be	be	AUX
ajst-10978	23	13	a	a	DET
ajst-10978	23	14	novel	novel	ADJ
ajst-10978	23	15	immunotherapeutic	immunotherapeutic	ADJ
ajst-10978	23	16	strategy	strategy	NOUN
ajst-10978	23	17	for	for	ADP
ajst-10978	23	18	bc	bc	PROPN
ajst-10978	23	19	.	.	PROPN
ajst-10978	24	1	however	however	ADV
ajst-10978	24	2	,	,	PUNCT
ajst-10978	24	3	different	different	ADJ
ajst-10978	24	4	types	type	NOUN
ajst-10978	24	5	of	of	ADP
ajst-10978	24	6	bc	bc	PROPN
ajst-10978	24	7	patients	patient	NOUN
ajst-10978	24	8	have	have	VERB
ajst-10978	24	9	different	different	ADJ
ajst-10978	24	10	clinical	clinical	ADJ
ajst-10978	24	11	responses	response	NOUN
ajst-10978	24	12	to	to	ADP
ajst-10978	24	13	pd-1	pd-1	ADJ
ajst-10978	24	14	/	/	SYM
ajst-10978	24	15	pdl1	pdl1	NOUN
ajst-10978	24	16	blockade	blockade	NOUN
ajst-10978	24	17	,	,	PUNCT
ajst-10978	24	18	clinical	clinical	ADJ
ajst-10978	24	19	use	use	NOUN
ajst-10978	24	20	of	of	ADP
ajst-10978	24	21	triple	triple	ADJ
ajst-10978	24	22	negative	negative	ADJ
ajst-10978	24	23	breast	breast	NOUN
ajst-10978	24	24	cancer	cancer	NOUN
ajst-10978	24	25	(	(	PUNCT
ajst-10978	24	26	tnbc	tnbc	ADV
ajst-10978	24	27	)	)	PUNCT
ajst-10978	24	28	is	be	AUX
ajst-10978	24	29	more	more	ADJ
ajst-10978	24	30	[	[	X
ajst-10978	24	31	11	11	NUM
ajst-10978	24	32	,	,	PUNCT
ajst-10978	24	33	12	12	NUM
ajst-10978	24	34	]	]	PUNCT
ajst-10978	24	35	.	.	PUNCT
ajst-10978	25	1	we	we	PRON
ajst-10978	25	2	believe	believe	VERB
ajst-10978	25	3	that	that	SCONJ
ajst-10978	25	4	in	in	ADP
ajst-10978	25	5	addition	addition	NOUN
ajst-10978	25	6	to	to	ADP
ajst-10978	25	7	pd-1	pd-1	ADJ
ajst-10978	25	8	and	and	CCONJ
ajst-10978	25	9	pd	pd	PROPN
ajst-10978	25	10	-	-	PROPN
ajst-10978	25	11	l1	l1	PROPN
ajst-10978	25	12	,	,	PUNCT
ajst-10978	25	13	there	there	PRON
ajst-10978	25	14	are	be	VERB
ajst-10978	25	15	other	other	ADJ
ajst-10978	25	16	factors	factor	NOUN
ajst-10978	25	17	that	that	PRON
ajst-10978	25	18	may	may	AUX
ajst-10978	25	19	aggravate	aggravate	VERB
ajst-10978	25	20	its	its	PRON
ajst-10978	25	21	immunosuppression	immunosuppression	NOUN
ajst-10978	25	22	,	,	PUNCT
ajst-10978	25	23	affect	affect	VERB
ajst-10978	25	24	its	its	PRON
ajst-10978	25	25	immunotherapeutic	immunotherapeutic	ADJ
ajst-10978	25	26	effect	effect	NOUN
ajst-10978	25	27	,	,	PUNCT
ajst-10978	25	28	and	and	CCONJ
ajst-10978	25	29	lead	lead	VERB
ajst-10978	25	30	to	to	ADP
ajst-10978	25	31	poor	poor	ADJ
ajst-10978	25	32	prognosis	prognosis	NOUN
ajst-10978	25	33	in	in	ADP
ajst-10978	25	34	patients	patient	NOUN
ajst-10978	25	35	with	with	ADP
ajst-10978	25	36	other	other	ADJ
ajst-10978	25	37	types	type	NOUN
ajst-10978	25	38	of	of	ADP
ajst-10978	25	39	bc	bc	PROPN
ajst-10978	25	40	.	.	PROPN
ajst-10978	25	41	stat1	stat1	PROPN
ajst-10978	25	42	exists	exist	VERB
ajst-10978	25	43	in	in	ADP
ajst-10978	25	44	cells	cell	NOUN
ajst-10978	25	45	in	in	ADP
ajst-10978	25	46	the	the	DET
ajst-10978	25	47	form	form	NOUN
ajst-10978	25	48	of	of	ADP
ajst-10978	25	49	inactive	inactive	ADJ
ajst-10978	25	50	monomer	monomer	NOUN
ajst-10978	25	51	in	in	ADP
ajst-10978	25	52	primarily	primarily	ADV
ajst-10978	25	53	.	.	PUNCT
ajst-10978	26	1	after	after	ADP
ajst-10978	26	2	phosphorylation	phosphorylation	NOUN
ajst-10978	26	3	by	by	ADP
ajst-10978	26	4	tyrosine	tyrosine	NOUN
ajst-10978	26	5	kinases	kinase	NOUN
ajst-10978	26	6	,	,	PUNCT
ajst-10978	26	7	stat1	stat1	PROPN
ajst-10978	26	8	is	be	AUX
ajst-10978	26	9	activated	activate	VERB
ajst-10978	26	10	to	to	PART
ajst-10978	26	11	form	form	VERB
ajst-10978	26	12	homologous	homologous	ADJ
ajst-10978	26	13	or	or	CCONJ
ajst-10978	26	14	heterodimer	heterodimer	NOUN
ajst-10978	26	15	.	.	PUNCT
ajst-10978	27	1	even	even	ADV
ajst-10978	27	2	after	after	ADP
ajst-10978	27	3	the	the	DET
ajst-10978	27	4	formation	formation	NOUN
ajst-10978	27	5	of	of	ADP
ajst-10978	27	6	polymers	polymer	NOUN
ajst-10978	27	7	and	and	CCONJ
ajst-10978	27	8	oligomers	oligomer	NOUN
ajst-10978	27	9	,	,	PUNCT
ajst-10978	27	10	stat1	stat1	X
ajst-10978	27	11	can	can	AUX
ajst-10978	27	12	also	also	ADV
ajst-10978	27	13	play	play	VERB
ajst-10978	27	14	a	a	DET
ajst-10978	27	15	physiological	physiological	ADJ
ajst-10978	27	16	role	role	NOUN
ajst-10978	27	17	,	,	PUNCT
ajst-10978	27	18	especially	especially	ADV
ajst-10978	27	19	in	in	ADP
ajst-10978	27	20	the	the	DET
ajst-10978	27	21	interferon	interferon	NOUN
ajst-10978	27	22	(	(	PUNCT
ajst-10978	27	23	ifn	ifn	NOUN
ajst-10978	27	24	)	)	PUNCT
ajst-10978	27	25	system	system	NOUN
ajst-10978	27	26	[	[	X
ajst-10978	27	27	13	13	NUM
ajst-10978	27	28	]	]	PUNCT
ajst-10978	27	29	.	.	PUNCT
ajst-10978	28	1	at	at	ADP
ajst-10978	28	2	the	the	DET
ajst-10978	28	3	same	same	ADJ
ajst-10978	28	4	time	time	NOUN
ajst-10978	28	5	,	,	PUNCT
ajst-10978	28	6	stat1	stat1	PROPN
ajst-10978	28	7	is	be	AUX
ajst-10978	28	8	defined	define	VERB
ajst-10978	28	9	as	as	ADP
ajst-10978	28	10	a	a	DET
ajst-10978	28	11	growth	growth	NOUN
ajst-10978	28	12	inhibitor	inhibitor	NOUN
ajst-10978	28	13	factor	factor	NOUN
ajst-10978	28	14	and	and	CCONJ
ajst-10978	28	15	a	a	DET
ajst-10978	28	16	apoptosis	apoptosis	NOUN
ajst-10978	28	17	factor	factor	NOUN
ajst-10978	28	18	due	due	ADP
ajst-10978	28	19	to	to	ADP
ajst-10978	28	20	its	its	PRON
ajst-10978	28	21	characteristics	characteristic	NOUN
ajst-10978	28	22	of	of	ADP
ajst-10978	28	23	promoting	promote	VERB
ajst-10978	28	24	apoptosis	apoptosis	NOUN
ajst-10978	28	25	and	and	CCONJ
ajst-10978	28	26	inhibiting	inhibit	VERB
ajst-10978	28	27	cell	cell	NOUN
ajst-10978	28	28	growth	growth	NOUN
ajst-10978	28	29	and	and	CCONJ
ajst-10978	28	30	differentiation	differentiation	NOUN
ajst-10978	28	31	,	,	PUNCT
ajst-10978	28	32	and	and	CCONJ
ajst-10978	28	33	it	it	PRON
ajst-10978	28	34	plays	play	VERB
ajst-10978	28	35	an	an	DET
ajst-10978	28	36	important	important	ADJ
ajst-10978	28	37	role	role	NOUN
ajst-10978	28	38	in	in	ADP
ajst-10978	28	39	inhibiting	inhibit	VERB
ajst-10978	28	40	the	the	DET
ajst-10978	28	41	occurrence	occurrence	NOUN
ajst-10978	28	42	and	and	CCONJ
ajst-10978	28	43	development	development	NOUN
ajst-10978	28	44	of	of	ADP
ajst-10978	28	45	tumors	tumor	NOUN
ajst-10978	28	46	.	.	PUNCT
ajst-10978	29	1	first	first	ADV
ajst-10978	29	2	of	of	ADP
ajst-10978	29	3	all	all	PRON
ajst-10978	29	4	,	,	PUNCT
ajst-10978	29	5	the	the	DET
ajst-10978	29	6	overexpression	overexpression	NOUN
ajst-10978	29	7	of	of	ADP
ajst-10978	29	8	stat1	stat1	NOUN
ajst-10978	29	9	is	be	AUX
ajst-10978	29	10	often	often	ADV
ajst-10978	29	11	observed	observe	VERB
ajst-10978	29	12	in	in	ADP
ajst-10978	29	13	the	the	DET
ajst-10978	29	14	pathogenesis	pathogenesis	NOUN
ajst-10978	29	15	of	of	ADP
ajst-10978	29	16	solid	solid	ADJ
ajst-10978	29	17	tumors	tumor	NOUN
ajst-10978	29	18	,	,	PUNCT
ajst-10978	29	19	which	which	PRON
ajst-10978	29	20	indicates	indicate	VERB
ajst-10978	29	21	that	that	SCONJ
ajst-10978	29	22	stat1	stat1	NOUN
ajst-10978	29	23	is	be	AUX
ajst-10978	29	24	indeed	indeed	ADV
ajst-10978	29	25	closely	closely	ADV
ajst-10978	29	26	related	relate	VERB
ajst-10978	29	27	to	to	ADP
ajst-10978	29	28	tumors	tumor	NOUN
ajst-10978	29	29	[	[	X
ajst-10978	29	30	13	13	NUM
ajst-10978	29	31	]	]	PUNCT
ajst-10978	29	32	.	.	PUNCT
ajst-10978	30	1	recently	recently	ADV
ajst-10978	30	2	,	,	PUNCT
ajst-10978	30	3	stat1	stat1	PROPN
ajst-10978	30	4	has	have	AUX
ajst-10978	30	5	been	be	AUX
ajst-10978	30	6	identified	identify	VERB
ajst-10978	30	7	as	as	ADP
ajst-10978	30	8	a	a	DET
ajst-10978	30	9	potential	potential	ADJ
ajst-10978	30	10	therapeutic	therapeutic	ADJ
ajst-10978	30	11	target	target	NOUN
ajst-10978	30	12	for	for	ADP
ajst-10978	30	13	malignancies	malignancy	NOUN
ajst-10978	30	14	,	,	PUNCT
ajst-10978	30	15	including	include	VERB
ajst-10978	30	16	breast	breast	NOUN
ajst-10978	30	17	cancer	cancer	NOUN
ajst-10978	30	18	,	,	PUNCT
ajst-10978	30	19	mainly	mainly	ADV
ajst-10978	30	20	through	through	ADP
ajst-10978	30	21	the	the	DET
ajst-10978	30	22	jak	jak	PROPN
ajst-10978	30	23	/	/	SYM
ajst-10978	30	24	stat1	stat1	PROPN
ajst-10978	30	25	signaling	signal	VERB
ajst-10978	30	26	pathway	pathway	NOUN
ajst-10978	30	27	that	that	PRON
ajst-10978	30	28	affects	affect	VERB
ajst-10978	30	29	the	the	DET
ajst-10978	30	30	body	body	NOUN
ajst-10978	30	31	's	's	PART
ajst-10978	30	32	normal	normal	ADJ
ajst-10978	30	33	immune	immune	ADJ
ajst-10978	30	34	system	system	NOUN
ajst-10978	30	35	[	[	X
ajst-10978	30	36	13	13	NUM
ajst-10978	30	37	,	,	PUNCT
ajst-10978	30	38	14	14	NUM
ajst-10978	30	39	]	]	PUNCT
ajst-10978	30	40	.	.	PUNCT
ajst-10978	31	1	the	the	DET
ajst-10978	31	2	expression	expression	NOUN
ajst-10978	31	3	of	of	ADP
ajst-10978	31	4	phospho‑stat1	phospho‑stat1	NOUN
ajst-10978	31	5	(	(	PUNCT
ajst-10978	31	6	p	p	NOUN
ajst-10978	31	7	-	-	PUNCT
ajst-10978	31	8	stat1	stat1	NOUN
ajst-10978	31	9	)	)	PUNCT
ajst-10978	31	10	in	in	ADP
ajst-10978	31	11	the	the	DET
ajst-10978	31	12	breast	breast	NOUN
ajst-10978	31	13	cancer	cancer	NOUN
ajst-10978	31	14	microenvironment	microenvironment	NOUN
ajst-10978	31	15	is	be	AUX
ajst-10978	31	16	a	a	DET
ajst-10978	31	17	potential	potential	ADJ
ajst-10978	31	18	biomarker	biomarker	NOUN
ajst-10978	31	19	.	.	PUNCT
ajst-10978	32	1	anti	anti	ADJ
ajst-10978	32	2	-	-	ADJ
ajst-10978	32	3	pd-1	pd-1	ADJ
ajst-10978	32	4	/	/	SYM
ajst-10978	32	5	anti	anti	ADJ
ajst-10978	32	6	-	-	ADJ
ajst-10978	32	7	pd	pd	ADJ
ajst-10978	32	8	-	-	PUNCT
ajst-10978	32	9	l1	l1	PROPN
ajst-10978	32	10	monoclonal	monoclonal	NOUN
ajst-10978	32	11	antibodies	antibody	NOUN
ajst-10978	32	12	have	have	AUX
ajst-10978	32	13	been	be	AUX
ajst-10978	32	14	used	use	VERB
ajst-10978	32	15	in	in	ADP
ajst-10978	32	16	immunotherapy	immunotherapy	NOUN
ajst-10978	32	17	of	of	ADP
ajst-10978	32	18	cancer	cancer	NOUN
ajst-10978	32	19	patients	patient	NOUN
ajst-10978	32	20	based	base	VERB
ajst-10978	32	21	on	on	ADP
ajst-10978	32	22	the	the	DET
ajst-10978	32	23	expression	expression	NOUN
ajst-10978	32	24	of	of	ADP
ajst-10978	32	25	p	p	NOUN
ajst-10978	32	26	-	-	PUNCT
ajst-10978	32	27	stat1	stat1	NOUN
ajst-10978	32	28	and	and	CCONJ
ajst-10978	32	29	pd	pd	PROPN
ajst-10978	32	30	-	-	PUNCT
ajst-10978	32	31	l1	l1	PROPN
ajst-10978	32	32	tumor	tumor	NOUN
ajst-10978	32	33	cells	cell	NOUN
ajst-10978	32	34	[	[	X
ajst-10978	32	35	14	14	NUM
ajst-10978	32	36	]	]	PUNCT
ajst-10978	32	37	.	.	PUNCT
ajst-10978	33	1	in	in	ADP
ajst-10978	33	2	addition	addition	NOUN
ajst-10978	33	3	,	,	PUNCT
ajst-10978	33	4	pd	pd	PROPN
ajst-10978	33	5	-	-	PROPN
ajst-10978	33	6	l1	l1	PROPN
ajst-10978	33	7	is	be	AUX
ajst-10978	33	8	downstream	downstream	ADJ
ajst-10978	33	9	of	of	ADP
ajst-10978	33	10	stat1	stat1	PROPN
ajst-10978	33	11	,	,	PUNCT
ajst-10978	33	12	and	and	CCONJ
ajst-10978	33	13	stat1	stat1	NOUN
ajst-10978	33	14	inhibition	inhibition	NOUN
ajst-10978	33	15	facilitates	facilitate	VERB
ajst-10978	33	16	the	the	DET
ajst-10978	33	17	anti	anti	ADJ
ajst-10978	33	18	-	-	ADJ
ajst-10978	33	19	tumor	tumor	ADJ
ajst-10978	33	20	immune	immune	ADJ
ajst-10978	33	21	response	response	NOUN
ajst-10978	33	22	in	in	ADP
ajst-10978	33	23	bc	bc	PROPN
ajst-10978	33	24	patients	patient	NOUN
ajst-10978	33	25	by	by	ADP
ajst-10978	33	26	suppressing	suppress	VERB
ajst-10978	33	27	pd	pd	ADJ
ajst-10978	33	28	-	-	PUNCT
ajst-10978	33	29	l1	l1	PROPN
ajst-10978	33	30	expression	expression	NOUN
ajst-10978	33	31	[	[	X
ajst-10978	33	32	15	15	NUM
ajst-10978	33	33	]	]	PUNCT
ajst-10978	33	34	.	.	PUNCT
ajst-10978	34	1	therefore	therefore	ADV
ajst-10978	34	2	,	,	PUNCT
ajst-10978	34	3	it	it	PRON
ajst-10978	34	4	is	be	AUX
ajst-10978	34	5	important	important	ADJ
ajst-10978	34	6	to	to	PART
ajst-10978	34	7	understand	understand	VERB
ajst-10978	34	8	the	the	DET
ajst-10978	34	9	correlation	correlation	NOUN
ajst-10978	34	10	between	between	ADP
ajst-10978	34	11	stat1	stat1	NOUN
ajst-10978	34	12	and	and	CCONJ
ajst-10978	34	13	pd-1	pd-1	ADJ
ajst-10978	34	14	/	/	SYM
ajst-10978	34	15	pd	pd	ADJ
ajst-10978	34	16	-	-	PUNCT
ajst-10978	34	17	l1	l1	PROPN
ajst-10978	34	18	signal	signal	PROPN
ajst-10978	34	19	channel	channel	PROPN
ajst-10978	34	20	in	in	ADP
ajst-10978	34	21	bc	bc	PROPN
ajst-10978	34	22	patients	patient	NOUN
ajst-10978	34	23	.	.	PUNCT
ajst-10978	35	1	in	in	ADP
ajst-10978	35	2	this	this	DET
ajst-10978	35	3	study	study	NOUN
ajst-10978	35	4	,	,	PUNCT
ajst-10978	35	5	the	the	DET
ajst-10978	35	6	expression	expression	NOUN
ajst-10978	35	7	of	of	ADP
ajst-10978	35	8	stat1	stat1	PROPN
ajst-10978	35	9	in	in	ADP
ajst-10978	35	10	breast	breast	NOUN
ajst-10978	35	11	cancer	cancer	NOUN
ajst-10978	35	12	was	be	AUX
ajst-10978	35	13	compared	compare	VERB
ajst-10978	35	14	between	between	ADP
ajst-10978	35	15	the	the	DET
ajst-10978	35	16	expression	expression	NOUN
ajst-10978	35	17	of	of	ADP
ajst-10978	35	18	different	different	ADJ
ajst-10978	35	19	types	type	NOUN
ajst-10978	35	20	of	of	ADP
ajst-10978	35	21	bc	bc	PROPN
ajst-10978	35	22	,	,	PUNCT
ajst-10978	35	23	to	to	PART
ajst-10978	35	24	illustrate	illustrate	VERB
ajst-10978	35	25	the	the	DET
ajst-10978	35	26	correlation	correlation	NOUN
ajst-10978	35	27	between	between	ADP
ajst-10978	35	28	stat1	stat1	NOUN
ajst-10978	35	29	and	and	CCONJ
ajst-10978	35	30	clinical	clinical	ADJ
ajst-10978	35	31	outcomes	outcome	NOUN
ajst-10978	35	32	of	of	ADP
ajst-10978	35	33	bc	bc	PROPN
ajst-10978	35	34	patients	patient	NOUN
ajst-10978	35	35	,	,	PUNCT
ajst-10978	35	36	and	and	CCONJ
ajst-10978	35	37	to	to	PART
ajst-10978	35	38	reveal	reveal	VERB
ajst-10978	35	39	how	how	SCONJ
ajst-10978	35	40	stat1	stat1	PROPN
ajst-10978	35	41	regulates	regulate	VERB
ajst-10978	35	42	the	the	DET
ajst-10978	35	43	pd-1	pd-1	NOUN
ajst-10978	35	44	/	/	SYM
ajst-10978	35	45	pd	pd	ADJ
ajst-10978	35	46	-	-	PROPN
ajst-10978	35	47	l1	l1	PROPN
ajst-10978	35	48	signaling	signal	VERB
ajst-10978	35	49	pathway	pathway	NOUN
ajst-10978	35	50	.	.	PUNCT
ajst-10978	36	1	furthermore	furthermore	ADV
ajst-10978	36	2	,	,	PUNCT
ajst-10978	36	3	to	to	PART
ajst-10978	36	4	investigate	investigate	VERB
ajst-10978	36	5	the	the	DET
ajst-10978	36	6	effects	effect	NOUN
ajst-10978	36	7	of	of	ADP
ajst-10978	36	8	pd-1	pd-1	ADP
ajst-10978	36	9	,	,	PUNCT
ajst-10978	36	10	pd	pd	PROPN
ajst-10978	36	11	-	-	PUNCT
ajst-10978	36	12	l1	l1	PROPN
ajst-10978	36	13	,	,	PUNCT
ajst-10978	36	14	stat1	stat1	PROPN
ajst-10978	36	15	,	,	PUNCT
ajst-10978	36	16	ido	ido	PROPN
ajst-10978	36	17	,	,	PUNCT
ajst-10978	36	18	ctla4	ctla4	NOUN
ajst-10978	36	19	,	,	PUNCT
ajst-10978	36	20	lag3	lag3	NOUN
ajst-10978	36	21	and	and	CCONJ
ajst-10978	36	22	fgl1	fgl1	PROPN
ajst-10978	36	23	on	on	ADP
ajst-10978	36	24	clinical	clinical	ADJ
ajst-10978	36	25	outcomes	outcome	NOUN
ajst-10978	36	26	of	of	ADP
ajst-10978	36	27	bc	bc	PROPN
ajst-10978	36	28	,	,	PUNCT
ajst-10978	36	29	and	and	CCONJ
ajst-10978	36	30	to	to	PART
ajst-10978	36	31	determine	determine	VERB
ajst-10978	36	32	its	its	PRON
ajst-10978	36	33	potential	potential	NOUN
ajst-10978	36	34	as	as	ADP
ajst-10978	36	35	a	a	DET
ajst-10978	36	36	biomarker	biomarker	NOUN
ajst-10978	36	37	for	for	ADP
ajst-10978	36	38	prognosis	prognosis	NOUN
ajst-10978	36	39	in	in	ADP
ajst-10978	36	40	bc	bc	PROPN
ajst-10978	36	41	patients	patient	NOUN
ajst-10978	36	42	.	.	PUNCT
ajst-10978	37	1	6	6	NUM
ajst-10978	37	2	2	2	NUM
ajst-10978	37	3	.	.	PUNCT
ajst-10978	37	4	expression	expression	NOUN
ajst-10978	37	5	of	of	ADP
ajst-10978	37	6	immune	immune	ADJ
ajst-10978	37	7	checkpoints	checkpoint	NOUN
ajst-10978	37	8	in	in	ADP
ajst-10978	37	9	breast	breast	NOUN
ajst-10978	37	10	cancer	cancer	NOUN
ajst-10978	37	11	female	female	ADJ
ajst-10978	37	12	breast	breast	NOUN
ajst-10978	37	13	cancer	cancer	NOUN
ajst-10978	37	14	has	have	AUX
ajst-10978	37	15	exceeded	exceed	VERB
ajst-10978	37	16	lung	lung	NOUN
ajst-10978	37	17	cancer	cancer	NOUN
ajst-10978	37	18	,	,	PUNCT
ajst-10978	37	19	becoming	become	VERB
ajst-10978	37	20	the	the	DET
ajst-10978	37	21	most	most	ADV
ajst-10978	37	22	often	often	ADV
ajst-10978	37	23	diagnosed	diagnose	VERB
ajst-10978	37	24	cancer	cancer	NOUN
ajst-10978	37	25	,	,	PUNCT
ajst-10978	37	26	and	and	CCONJ
ajst-10978	37	27	it	it	PRON
ajst-10978	37	28	is	be	AUX
ajst-10978	37	29	also	also	ADV
ajst-10978	37	30	the	the	DET
ajst-10978	37	31	primary	primary	ADJ
ajst-10978	37	32	cause	cause	NOUN
ajst-10978	37	33	of	of	ADP
ajst-10978	37	34	female	female	ADJ
ajst-10978	37	35	cancer	cancer	NOUN
ajst-10978	37	36	-related	-relate	VERB
ajst-10978	37	37	death	death	NOUN
ajst-10978	37	38	.	.	PUNCT
ajst-10978	38	1	in	in	ADP
ajst-10978	38	2	2020	2020	NUM
ajst-10978	38	3	,	,	PUNCT
ajst-10978	38	4	there	there	PRON
ajst-10978	38	5	were	be	VERB
ajst-10978	38	6	2.26	2.26	NUM
ajst-10978	38	7	million	million	NUM
ajst-10978	38	8	new	new	ADJ
ajst-10978	38	9	cases	case	NOUN
ajst-10978	38	10	of	of	ADP
ajst-10978	38	11	breast	breast	NOUN
ajst-10978	38	12	cancer	cancer	NOUN
ajst-10978	38	13	in	in	ADP
ajst-10978	38	14	the	the	DET
ajst-10978	38	15	world	world	NOUN
ajst-10978	38	16	,	,	PUNCT
ajst-10978	38	17	surpassing	surpass	VERB
ajst-10978	38	18	lung	lung	NOUN
ajst-10978	38	19	cancer	cancer	NOUN
ajst-10978	38	20	(	(	PUNCT
ajst-10978	38	21	2.21	2.21	NUM
ajst-10978	38	22	million	million	NUM
ajst-10978	38	23	)	)	PUNCT
ajst-10978	38	24	to	to	PART
ajst-10978	38	25	become	become	VERB
ajst-10978	38	26	the	the	DET
ajst-10978	38	27	world	world	NOUN
ajst-10978	38	28	's	's	PART
ajst-10978	38	29	largest	large	ADJ
ajst-10978	38	30	cancer	cancer	NOUN
ajst-10978	38	31	,	,	PUNCT
ajst-10978	38	32	accounting	account	VERB
ajst-10978	38	33	for	for	ADP
ajst-10978	38	34	11.7	11.7	NUM
ajst-10978	38	35	%	%	NOUN
ajst-10978	38	36	of	of	ADP
ajst-10978	38	37	the	the	DET
ajst-10978	38	38	global	global	ADJ
ajst-10978	38	39	new	new	ADJ
ajst-10978	38	40	cancer	cancer	NOUN
ajst-10978	38	41	cases[16]the	cases[16]the	DET
ajst-10978	38	42	high	high	ADJ
ajst-10978	38	43	incidence	incidence	NOUN
ajst-10978	38	44	of	of	ADP
ajst-10978	38	45	breast	breast	NOUN
ajst-10978	38	46	cancer	cancer	NOUN
ajst-10978	38	47	has	have	AUX
ajst-10978	38	48	brought	bring	VERB
ajst-10978	38	49	a	a	DET
ajst-10978	38	50	heavy	heavy	ADJ
ajst-10978	38	51	disease	disease	NOUN
ajst-10978	38	52	burden	burden	NOUN
ajst-10978	38	53	to	to	ADP
ajst-10978	38	54	women	woman	NOUN
ajst-10978	38	55	,	,	PUNCT
ajst-10978	38	56	which	which	PRON
ajst-10978	38	57	seriously	seriously	ADV
ajst-10978	38	58	affects	affect	VERB
ajst-10978	38	59	women	woman	NOUN
ajst-10978	38	60	's	's	PART
ajst-10978	38	61	physical	physical	ADJ
ajst-10978	38	62	and	and	CCONJ
ajst-10978	38	63	mental	mental	ADJ
ajst-10978	38	64	health	health	NOUN
ajst-10978	38	65	and	and	CCONJ
ajst-10978	38	66	quality	quality	NOUN
ajst-10978	38	67	of	of	ADP
ajst-10978	38	68	life	life	NOUN
ajst-10978	38	69	.	.	PUNCT
ajst-10978	39	1	the	the	DET
ajst-10978	39	2	immune	immune	ADJ
ajst-10978	39	3	examination	examination	NOUN
ajst-10978	39	4	point	point	NOUN
ajst-10978	39	5	also	also	ADV
ajst-10978	39	6	plays	play	VERB
ajst-10978	39	7	an	an	DET
ajst-10978	39	8	important	important	ADJ
ajst-10978	39	9	role	role	NOUN
ajst-10978	39	10	in	in	ADP
ajst-10978	39	11	breast	breast	NOUN
ajst-10978	39	12	cancer	cancer	NOUN
ajst-10978	39	13	.	.	PUNCT
ajst-10978	40	1	some	some	DET
ajst-10978	40	2	studies	study	NOUN
ajst-10978	40	3	have	have	AUX
ajst-10978	40	4	found	find	VERB
ajst-10978	40	5	that	that	SCONJ
ajst-10978	40	6	targeting	target	VERB
ajst-10978	40	7	pd	pd	PROPN
ajst-10978	40	8	-	-	PROPN
ajst-10978	40	9	l1	l1	PROPN
ajst-10978	40	10	may	may	AUX
ajst-10978	40	11	be	be	AUX
ajst-10978	40	12	a	a	DET
ajst-10978	40	13	promising	promising	ADJ
ajst-10978	40	14	treatment	treatment	NOUN
ajst-10978	40	15	method	method	NOUN
ajst-10978	40	16	for	for	ADP
ajst-10978	40	17	patients	patient	NOUN
ajst-10978	40	18	with	with	ADP
ajst-10978	40	19	breast	breast	NOUN
ajst-10978	40	20	cancer	cancer	NOUN
ajst-10978	40	21	.	.	PUNCT
ajst-10978	41	1	and	and	CCONJ
ajst-10978	41	2	the	the	DET
ajst-10978	41	3	conduction	conduction	NOUN
ajst-10978	41	4	of	of	ADP
ajst-10978	41	5	the	the	DET
ajst-10978	41	6	upstream	upstream	ADJ
ajst-10978	41	7	stat1	stat1	PROPN
ajst-10978	41	8	signal	signal	NOUN
ajst-10978	41	9	is	be	AUX
ajst-10978	41	10	the	the	DET
ajst-10978	41	11	potential	potential	ADJ
ajst-10978	41	12	molecular	molecular	ADJ
ajst-10978	41	13	mechanism	mechanism	NOUN
ajst-10978	41	14	of	of	ADP
ajst-10978	41	15	the	the	DET
ajst-10978	41	16	lower	low	ADJ
ajst-10978	41	17	pdl1[17	pdl1[17	PROPN
ajst-10978	41	18	]	]	PUNCT
ajst-10978	41	19	.studies	.studie	NOUN
ajst-10978	41	20	have	have	AUX
ajst-10978	41	21	found	find	VERB
ajst-10978	41	22	that	that	SCONJ
ajst-10978	41	23	stat1	stat1	PROPN
ajst-10978	41	24	breast	breast	NOUN
ajst-10978	41	25	cancer	cancer	NOUN
ajst-10978	41	26	cell	cell	NOUN
ajst-10978	41	27	proliferation	proliferation	NOUN
ajst-10978	41	28	,	,	PUNCT
ajst-10978	41	29	invasion	invasion	NOUN
ajst-10978	41	30	,	,	PUNCT
ajst-10978	41	31	blood	blood	NOUN
ajst-10978	41	32	vessel	vessel	NOUN
ajst-10978	41	33	generation	generation	NOUN
ajst-10978	41	34	,	,	PUNCT
ajst-10978	41	35	metastasis	metastasis	NOUN
ajst-10978	41	36	and	and	CCONJ
ajst-10978	41	37	immune	immune	ADJ
ajst-10978	41	38	escape	escape	NOUN
ajst-10978	41	39	have	have	VERB
ajst-10978	41	40	a	a	DET
ajst-10978	41	41	key	key	ADJ
ajst-10978	41	42	role[18].p	role[18].p	NOUN
ajst-10978	41	43	-	-	PUNCT
ajst-10978	41	44	stat1	stat1	NOUN
ajst-10978	41	45	expression	expression	NOUN
ajst-10978	41	46	may	may	AUX
ajst-10978	41	47	be	be	AUX
ajst-10978	41	48	potential	potential	ADJ
ajst-10978	41	49	biomarkers	biomarker	NOUN
ajst-10978	41	50	for	for	SCONJ
ajst-10978	41	51	patients	patient	NOUN
ajst-10978	41	52	to	to	PART
ajst-10978	41	53	choose	choose	VERB
ajst-10978	41	54	anti	anti	ADJ
ajst-10978	41	55	-	-	ADJ
ajst-10978	41	56	pd1	pd1	VERB
ajst-10978	41	57	/	/	SYM
ajst-10978	41	58	anti	anti	ADJ
ajst-10978	41	59	-	-	ADJ
ajst-10978	41	60	pd	pd	ADJ
ajst-10978	41	61	-	-	PUNCT
ajst-10978	41	62	l1	l1	PROPN
ajst-10978	41	63	monoclonal	monoclonal	NOUN
ajst-10978	41	64	antibody	antibody	NOUN
ajst-10978	41	65	immunotherapy[19	immunotherapy[19	ADV
ajst-10978	41	66	]	]	X
ajst-10978	41	67	.	.	PUNCT
ajst-10978	42	1	similarly	similarly	ADV
ajst-10978	42	2	,	,	PUNCT
ajst-10978	42	3	the	the	DET
ajst-10978	42	4	occurrence	occurrence	NOUN
ajst-10978	42	5	of	of	ADP
ajst-10978	42	6	ido	ido	PROPN
ajst-10978	42	7	,	,	PUNCT
ajst-10978	42	8	ctla-4	ctla-4	PROPN
ajst-10978	42	9	,	,	PUNCT
ajst-10978	42	10	lag3	lag3	PROPN
ajst-10978	42	11	and	and	CCONJ
ajst-10978	42	12	fgl1	fgl1	PROPN
ajst-10978	42	13	also	also	ADV
ajst-10978	42	14	plays	play	VERB
ajst-10978	42	15	an	an	DET
ajst-10978	42	16	important	important	ADJ
ajst-10978	42	17	role	role	NOUN
ajst-10978	42	18	in	in	ADP
ajst-10978	42	19	breast	breast	NOUN
ajst-10978	42	20	cancer	cancer	NOUN
ajst-10978	42	21	.	.	PUNCT
ajst-10978	43	1	the	the	DET
ajst-10978	43	2	expression	expression	NOUN
ajst-10978	43	3	of	of	ADP
ajst-10978	43	4	ido	ido	NOUN
ajst-10978	43	5	is	be	AUX
ajst-10978	43	6	related	relate	VERB
ajst-10978	43	7	to	to	ADP
ajst-10978	43	8	er	er	INTJ
ajst-10978	43	9	and	and	CCONJ
ajst-10978	43	10	pr	pr	NOUN
ajst-10978	43	11	,	,	PUNCT
ajst-10978	43	12	while	while	SCONJ
ajst-10978	43	13	tnbc	tnbc	NOUN
ajst-10978	43	14	shows	show	VERB
ajst-10978	43	15	high	high	ADJ
ajst-10978	43	16	expression	expression	NOUN
ajst-10978	43	17	of	of	ADP
ajst-10978	43	18	pd	pd	PROPN
ajst-10978	43	19	-	-	PROPN
ajst-10978	43	20	l1	l1	PROPN
ajst-10978	43	21	and	and	CCONJ
ajst-10978	43	22	ido	ido	NOUN
ajst-10978	43	23	in	in	ADP
ajst-10978	43	24	tnbc	tnbc	ADV
ajst-10978	43	25	.	.	PUNCT
ajst-10978	44	1	ido	ido	NOUN
ajst-10978	44	2	expression	expression	NOUN
ajst-10978	44	3	is	be	AUX
ajst-10978	44	4	very	very	ADV
ajst-10978	44	5	common	common	ADJ
ajst-10978	44	6	in	in	ADP
ajst-10978	44	7	tnbc	tnbc	PROPN
ajst-10978	44	8	,	,	PUNCT
ajst-10978	44	9	which	which	PRON
ajst-10978	44	10	is	be	AUX
ajst-10978	44	11	high	high	ADJ
ajst-10978	44	12	-	-	PUNCT
ajst-10978	44	13	level	level	NOUN
ajst-10978	44	14	three	three	NUM
ajst-10978	44	15	-	-	PUNCT
ajst-10978	44	16	negative	negative	ADJ
ajst-10978	44	17	breast	breast	NOUN
ajst-10978	44	18	cancer	cancer	NOUN
ajst-10978	44	19	,	,	PUNCT
ajst-10978	44	20	and	and	CCONJ
ajst-10978	44	21	is	be	AUX
ajst-10978	44	22	often	often	ADV
ajst-10978	44	23	related	relate	VERB
ajst-10978	44	24	to	to	ADP
ajst-10978	44	25	pd	pd	NOUN
ajst-10978	44	26	-	-	PUNCT
ajst-10978	44	27	l1	l1	PROPN
ajst-10978	44	28	,	,	PUNCT
ajst-10978	44	29	which	which	PRON
ajst-10978	44	30	indicates	indicate	VERB
ajst-10978	44	31	that	that	SCONJ
ajst-10978	44	32	ido	ido	PROPN
ajst-10978	44	33	may	may	AUX
ajst-10978	44	34	be	be	AUX
ajst-10978	44	35	a	a	DET
ajst-10978	44	36	mechanism	mechanism	NOUN
ajst-10978	44	37	for	for	ADP
ajst-10978	44	38	anti	anti	ADJ
ajst-10978	44	39	-	-	ADJ
ajst-10978	44	40	pd1	pd1	VERB
ajst-10978	44	41	/	/	SYM
ajst-10978	44	42	pd	pd	NOUN
ajst-10978	44	43	-	-	PROPN
ajst-10978	44	44	l1	l1	PROPN
ajst-10978	44	45	immunotherapy	immunotherapy	NOUN
ajst-10978	44	46	and	and	CCONJ
ajst-10978	44	47	drug	drug	NOUN
ajst-10978	44	48	resistance	resistance	NOUN
ajst-10978	44	49	[	[	X
ajst-10978	44	50	20	20	NUM
ajst-10978	44	51	-	-	SYM
ajst-10978	44	52	21	21	NUM
ajst-10978	44	53	]	]	PUNCT
ajst-10978	44	54	.	.	PUNCT
ajst-10978	45	1	in	in	ADP
ajst-10978	45	2	addition	addition	NOUN
ajst-10978	45	3	,	,	PUNCT
ajst-10978	45	4	the	the	DET
ajst-10978	45	5	literator	literator	NOUN
ajst-10978	45	6	reports	report	VERB
ajst-10978	45	7	some	some	DET
ajst-10978	45	8	associations	association	NOUN
ajst-10978	45	9	between	between	ADP
ajst-10978	45	10	ctla-4	ctla-4	PROPN
ajst-10978	45	11	,	,	PUNCT
ajst-10978	45	12	lag3	lag3	NOUN
ajst-10978	45	13	and	and	CCONJ
ajst-10978	45	14	fgl1	fgl1	PROPN
ajst-10978	45	15	in	in	ADP
ajst-10978	45	16	the	the	DET
ajst-10978	45	17	tumor	tumor	NOUN
ajst-10978	45	18	microe	microe	PROPN
ajst-10978	45	19	environment	environment	NOUN
ajst-10978	45	20	3	3	X
ajst-10978	45	21	.	.	PUNCT
ajst-10978	46	1	discussion	discussion	NOUN
ajst-10978	46	2	stat1	stat1	PROPN
ajst-10978	46	3	plays	play	VERB
ajst-10978	46	4	a	a	DET
ajst-10978	46	5	significant	significant	ADJ
ajst-10978	46	6	role	role	NOUN
ajst-10978	46	7	in	in	ADP
ajst-10978	46	8	the	the	DET
ajst-10978	46	9	progression	progression	NOUN
ajst-10978	46	10	and	and	CCONJ
ajst-10978	46	11	prognosis	prognosis	NOUN
ajst-10978	46	12	of	of	ADP
ajst-10978	46	13	various	various	ADJ
ajst-10978	46	14	tumors	tumor	NOUN
ajst-10978	46	15	such	such	ADJ
ajst-10978	46	16	as	as	ADP
ajst-10978	46	17	gastric	gastric	ADJ
ajst-10978	46	18	cancer	cancer	NOUN
ajst-10978	46	19	,	,	PUNCT
ajst-10978	46	20	colorectal	colorectal	ADJ
ajst-10978	46	21	cancer	cancer	NOUN
ajst-10978	46	22	,	,	PUNCT
ajst-10978	46	23	ovarian	ovarian	ADJ
ajst-10978	46	24	cancer	cancer	NOUN
ajst-10978	46	25	and	and	CCONJ
ajst-10978	46	26	other	other	ADJ
ajst-10978	46	27	tumors	tumor	NOUN
ajst-10978	47	1	[	[	X
ajst-10978	47	2	22	22	NUM
ajst-10978	47	3	-	-	SYM
ajst-10978	47	4	2	2	NUM
ajst-10978	47	5	]	]	PUNCT
ajst-10978	47	6	.	.	PUNCT
ajst-10978	48	1	we	we	PRON
ajst-10978	48	2	all	all	PRON
ajst-10978	48	3	know	know	VERB
ajst-10978	48	4	that	that	SCONJ
ajst-10978	48	5	the	the	DET
ajst-10978	48	6	combined	combine	VERB
ajst-10978	48	7	of	of	ADP
ajst-10978	48	8	pd-1	pd-1	ADJ
ajst-10978	48	9	and	and	CCONJ
ajst-10978	48	10	pd	pd	PROPN
ajst-10978	48	11	-	-	PROPN
ajst-10978	48	12	l1	l1	PROPN
ajst-10978	48	13	has	have	VERB
ajst-10978	48	14	a	a	DET
ajst-10978	48	15	negative	negative	ADJ
ajst-10978	48	16	regulatory	regulatory	ADJ
ajst-10978	48	17	effect	effect	NOUN
ajst-10978	48	18	on	on	ADP
ajst-10978	48	19	the	the	DET
ajst-10978	48	20	immune	immune	ADJ
ajst-10978	48	21	system	system	NOUN
ajst-10978	48	22	in	in	ADP
ajst-10978	48	23	cancer	cancer	NOUN
ajst-10978	48	24	patients	patient	NOUN
ajst-10978	48	25	.	.	PUNCT
ajst-10978	49	1	however	however	ADV
ajst-10978	49	2	,	,	PUNCT
ajst-10978	49	3	little	little	ADJ
ajst-10978	49	4	is	be	AUX
ajst-10978	49	5	known	know	VERB
ajst-10978	49	6	about	about	ADP
ajst-10978	49	7	the	the	DET
ajst-10978	49	8	prognostic	prognostic	ADJ
ajst-10978	49	9	value	value	NOUN
ajst-10978	49	10	of	of	ADP
ajst-10978	49	11	stat1	stat1	PROPN
ajst-10978	49	12	in	in	ADP
ajst-10978	49	13	bc	bc	PROPN
ajst-10978	49	14	patients	patient	NOUN
ajst-10978	49	15	and	and	CCONJ
ajst-10978	49	16	how	how	SCONJ
ajst-10978	49	17	stat1	stat1	NOUN
ajst-10978	49	18	affects	affect	VERB
ajst-10978	49	19	the	the	DET
ajst-10978	49	20	expression	expression	NOUN
ajst-10978	49	21	of	of	ADP
ajst-10978	49	22	pdl1	pdl1	NOUN
ajst-10978	49	23	in	in	ADP
ajst-10978	49	24	tumor	tumor	NOUN
ajst-10978	49	25	cells	cell	NOUN
ajst-10978	49	26	[	[	X
ajst-10978	49	27	25	25	NUM
ajst-10978	49	28	]	]	PUNCT
ajst-10978	49	29	.	.	PUNCT
ajst-10978	50	1	this	this	DET
ajst-10978	50	2	study	study	NOUN
ajst-10978	50	3	investigated	investigate	VERB
ajst-10978	50	4	the	the	DET
ajst-10978	50	5	relationship	relationship	NOUN
ajst-10978	50	6	between	between	ADP
ajst-10978	50	7	stat1	stat1	NOUN
ajst-10978	50	8	expression	expression	NOUN
ajst-10978	50	9	and	and	CCONJ
ajst-10978	50	10	os	os	NOUN
ajst-10978	50	11	in	in	ADP
ajst-10978	50	12	patients	patient	NOUN
ajst-10978	50	13	with	with	ADP
ajst-10978	50	14	bc	bc	PROPN
ajst-10978	50	15	.	.	PUNCT
ajst-10978	51	1	we	we	PRON
ajst-10978	51	2	found	find	VERB
ajst-10978	51	3	that	that	SCONJ
ajst-10978	51	4	overexpression	overexpression	NOUN
ajst-10978	51	5	of	of	ADP
ajst-10978	51	6	stat1	stat1	PROPN
ajst-10978	51	7	predicts	predict	NOUN
ajst-10978	51	8	poor	poor	ADJ
ajst-10978	51	9	os	os	ADV
ajst-10978	51	10	in	in	ADP
ajst-10978	51	11	bc	bc	PROPN
ajst-10978	51	12	,	,	PUNCT
ajst-10978	51	13	stat1	stat1	PROPN
ajst-10978	51	14	was	be	AUX
ajst-10978	51	15	positively	positively	ADV
ajst-10978	51	16	correlated	correlate	VERB
ajst-10978	51	17	with	with	ADP
ajst-10978	51	18	pd	pd	PROPN
ajst-10978	51	19	-	-	PUNCT
ajst-10978	51	20	l1	l1	PROPN
ajst-10978	51	21	.	.	PUNCT
ajst-10978	52	1	therefore	therefore	ADV
ajst-10978	52	2	,	,	PUNCT
ajst-10978	52	3	stat1	stat1	ADJ
ajst-10978	52	4	inhibitors	inhibitor	NOUN
ajst-10978	52	5	can	can	AUX
ajst-10978	52	6	be	be	AUX
ajst-10978	52	7	used	use	VERB
ajst-10978	52	8	in	in	ADP
ajst-10978	52	9	combination	combination	NOUN
ajst-10978	52	10	with	with	ADP
ajst-10978	52	11	pd	pd	PROPN
ajst-10978	52	12	-	-	PUNCT
ajst-10978	52	13	l1	l1	PROPN
ajst-10978	52	14	monoclonal	monoclonal	NOUN
ajst-10978	52	15	antibodies	antibodie	VERB
ajst-10978	52	16	to	to	PART
ajst-10978	52	17	achieve	achieve	VERB
ajst-10978	52	18	optimal	optimal	ADJ
ajst-10978	52	19	therapeutic	therapeutic	ADJ
ajst-10978	52	20	efficacy	efficacy	NOUN
ajst-10978	52	21	.	.	PUNCT
ajst-10978	53	1	more	more	ADV
ajst-10978	53	2	importantly	importantly	ADV
ajst-10978	53	3	,	,	PUNCT
ajst-10978	53	4	immune	immune	ADJ
ajst-10978	53	5	checkpoints	checkpoint	NOUN
ajst-10978	53	6	can	can	AUX
ajst-10978	53	7	be	be	AUX
ajst-10978	53	8	used	use	VERB
ajst-10978	53	9	as	as	ADP
ajst-10978	53	10	biomarkers	biomarker	NOUN
ajst-10978	53	11	to	to	PART
ajst-10978	53	12	predict	predict	VERB
ajst-10978	53	13	the	the	DET
ajst-10978	53	14	prognosis	prognosis	NOUN
ajst-10978	53	15	of	of	ADP
ajst-10978	53	16	patients	patient	NOUN
ajst-10978	53	17	with	with	ADP
ajst-10978	53	18	bc	bc	PROPN
ajst-10978	53	19	.	.	PUNCT
ajst-10978	54	1	the	the	DET
ajst-10978	54	2	expression	expression	NOUN
ajst-10978	54	3	of	of	ADP
ajst-10978	54	4	immune	immune	ADJ
ajst-10978	54	5	checkpoint	checkpoint	NOUN
ajst-10978	54	6	molecules	molecule	NOUN
ajst-10978	54	7	on	on	ADP
ajst-10978	54	8	t	t	NOUN
ajst-10978	54	9	cells	cell	NOUN
ajst-10978	54	10	is	be	AUX
ajst-10978	54	11	considered	consider	VERB
ajst-10978	54	12	to	to	PART
ajst-10978	54	13	be	be	AUX
ajst-10978	54	14	one	one	NUM
ajst-10978	54	15	of	of	ADP
ajst-10978	54	16	the	the	DET
ajst-10978	54	17	important	important	ADJ
ajst-10978	54	18	regulatory	regulatory	ADJ
ajst-10978	54	19	mechanisms	mechanism	NOUN
ajst-10978	54	20	for	for	ADP
ajst-10978	54	21	immune	immune	ADJ
ajst-10978	54	22	cells	cell	NOUN
ajst-10978	54	23	to	to	PART
ajst-10978	54	24	regulate	regulate	VERB
ajst-10978	54	25	their	their	PRON
ajst-10978	54	26	own	own	ADJ
ajst-10978	54	27	antigen	antigen	ADJ
ajst-10978	54	28	response	response	NOUN
ajst-10978	54	29	[	[	X
ajst-10978	54	30	26	26	NUM
ajst-10978	54	31	,	,	PUNCT
ajst-10978	54	32	27	27	NUM
ajst-10978	54	33	]	]	PUNCT
ajst-10978	54	34	.	.	PUNCT
ajst-10978	55	1	some	some	DET
ajst-10978	55	2	studies	study	NOUN
ajst-10978	55	3	have	have	AUX
ajst-10978	55	4	shown	show	VERB
ajst-10978	55	5	that	that	SCONJ
ajst-10978	55	6	immune	immune	ADJ
ajst-10978	55	7	checkpoints	checkpoint	NOUN
ajst-10978	55	8	such	such	ADJ
ajst-10978	55	9	as	as	ADP
ajst-10978	55	10	pd-1	pd-1	ADV
ajst-10978	55	11	,	,	PUNCT
ajst-10978	55	12	ctla-4	ctla-4	NOUN
ajst-10978	55	13	and	and	CCONJ
ajst-10978	55	14	lag-3	lag-3	X
ajst-10978	55	15	are	be	AUX
ajst-10978	55	16	upregulated	upregulate	VERB
ajst-10978	55	17	on	on	ADP
ajst-10978	55	18	the	the	DET
ajst-10978	55	19	surface	surface	NOUN
ajst-10978	55	20	of	of	ADP
ajst-10978	55	21	t	t	PROPN
ajst-10978	55	22	cells	cell	NOUN
ajst-10978	55	23	in	in	ADP
ajst-10978	55	24	breast	breast	NOUN
ajst-10978	55	25	tumor	tumor	NOUN
ajst-10978	55	26	tissues	tissue	NOUN
ajst-10978	55	27	.	.	PUNCT
ajst-10978	56	1	the	the	DET
ajst-10978	56	2	epigenetic	epigenetic	ADJ
ajst-10978	56	3	modifications	modification	NOUN
ajst-10978	56	4	behind	behind	ADP
ajst-10978	56	5	their	their	PRON
ajst-10978	56	6	upregulation	upregulation	NOUN
ajst-10978	56	7	are	be	AUX
ajst-10978	56	8	depends	depend	VERB
ajst-10978	56	9	on	on	ADP
ajst-10978	56	10	the	the	DET
ajst-10978	56	11	methylation	methylation	NOUN
ajst-10978	56	12	of	of	ADP
ajst-10978	56	13	dna	dna	PROPN
ajst-10978	56	14	and	and	CCONJ
ajst-10978	56	15	the	the	DET
ajst-10978	56	16	distribution	distribution	NOUN
ajst-10978	56	17	of	of	ADP
ajst-10978	56	18	inhibitory	inhibitory	ADJ
ajst-10978	56	19	histone	histone	NOUN
ajst-10978	56	20	[	[	X
ajst-10978	56	21	28	28	NUM
ajst-10978	56	22	]	]	PUNCT
ajst-10978	56	23	.	.	PUNCT
ajst-10978	57	1	therefore	therefore	ADV
ajst-10978	57	2	,	,	PUNCT
ajst-10978	57	3	the	the	DET
ajst-10978	57	4	combination	combination	NOUN
ajst-10978	57	5	of	of	ADP
ajst-10978	57	6	targeted	target	VERB
ajst-10978	57	7	drugs	drug	NOUN
ajst-10978	57	8	and	and	CCONJ
ajst-10978	57	9	stat1	stat1	NOUN
ajst-10978	57	10	blocking	blocking	NOUN
ajst-10978	57	11	function	function	NOUN
ajst-10978	57	12	is	be	AUX
ajst-10978	57	13	a	a	DET
ajst-10978	57	14	new	new	ADJ
ajst-10978	57	15	strategy	strategy	NOUN
ajst-10978	57	16	for	for	ADP
ajst-10978	57	17	the	the	DET
ajst-10978	57	18	treatment	treatment	NOUN
ajst-10978	57	19	of	of	ADP
ajst-10978	57	20	tumors	tumor	NOUN
ajst-10978	57	21	.	.	PUNCT
ajst-10978	58	1	recent	recent	ADJ
ajst-10978	58	2	studies	study	NOUN
ajst-10978	58	3	have	have	AUX
ajst-10978	58	4	shown	show	VERB
ajst-10978	58	5	that	that	DET
ajst-10978	58	6	combination	combination	NOUN
ajst-10978	58	7	therapy	therapy	NOUN
ajst-10978	58	8	of	of	ADP
ajst-10978	58	9	icb	icb	PROPN
ajst-10978	58	10	with	with	ADP
ajst-10978	58	11	other	other	ADJ
ajst-10978	58	12	targeted	target	VERB
ajst-10978	58	13	agents	agent	NOUN
ajst-10978	58	14	has	have	VERB
ajst-10978	58	15	the	the	DET
ajst-10978	58	16	potential	potential	NOUN
ajst-10978	58	17	to	to	PART
ajst-10978	58	18	enhance	enhance	VERB
ajst-10978	58	19	the	the	DET
ajst-10978	58	20	anti	anti	ADJ
ajst-10978	58	21	-	-	ADJ
ajst-10978	58	22	tumor	tumor	ADJ
ajst-10978	58	23	response	response	NOUN
ajst-10978	58	24	of	of	ADP
ajst-10978	58	25	bc	bc	PROPN
ajst-10978	59	1	[	[	X
ajst-10978	59	2	29	29	NUM
ajst-10978	59	3	,	,	PUNCT
ajst-10978	59	4	30	30	NUM
ajst-10978	59	5	]	]	PUNCT
ajst-10978	59	6	.	.	PUNCT
ajst-10978	60	1	besides	besides	SCONJ
ajst-10978	60	2	that	that	PRON
ajst-10978	60	3	,	,	PUNCT
ajst-10978	60	4	pd	pd	PROPN
ajst-10978	60	5	-	-	PROPN
ajst-10978	60	6	l1	l1	PROPN
ajst-10978	60	7	has	have	AUX
ajst-10978	60	8	been	be	AUX
ajst-10978	60	9	proved	prove	VERB
ajst-10978	60	10	to	to	PART
ajst-10978	60	11	be	be	AUX
ajst-10978	60	12	a	a	DET
ajst-10978	60	13	immediate	immediate	ADJ
ajst-10978	60	14	target	target	NOUN
ajst-10978	60	15	for	for	ADP
ajst-10978	60	16	stat1	stat1	ADJ
ajst-10978	60	17	-	-	PUNCT
ajst-10978	60	18	mediated	mediate	VERB
ajst-10978	60	19	gene	gene	NOUN
ajst-10978	60	20	expression	expression	NOUN
ajst-10978	60	21	[	[	X
ajst-10978	60	22	31	31	NUM
ajst-10978	60	23	]	]	PUNCT
ajst-10978	60	24	.	.	PUNCT
ajst-10978	61	1	in	in	ADP
ajst-10978	61	2	this	this	DET
ajst-10978	61	3	study	study	NOUN
ajst-10978	61	4	,	,	PUNCT
ajst-10978	61	5	we	we	PRON
ajst-10978	61	6	found	find	VERB
ajst-10978	61	7	that	that	SCONJ
ajst-10978	61	8	the	the	DET
ajst-10978	61	9	expression	expression	NOUN
ajst-10978	61	10	of	of	ADP
ajst-10978	61	11	stat1	stat1	NOUN
ajst-10978	61	12	in	in	ADP
ajst-10978	61	13	all	all	DET
ajst-10978	61	14	bc	bc	PROPN
ajst-10978	61	15	patients	patient	NOUN
ajst-10978	61	16	was	be	AUX
ajst-10978	61	17	increased	increase	VERB
ajst-10978	61	18	.	.	PUNCT
ajst-10978	62	1	then	then	ADV
ajst-10978	62	2	,	,	PUNCT
ajst-10978	62	3	it	it	PRON
ajst-10978	62	4	was	be	AUX
ajst-10978	62	5	also	also	ADV
ajst-10978	62	6	found	find	VERB
ajst-10978	62	7	that	that	SCONJ
ajst-10978	62	8	the	the	DET
ajst-10978	62	9	expression	expression	NOUN
ajst-10978	62	10	of	of	ADP
ajst-10978	62	11	stat1	stat1	NOUN
ajst-10978	62	12	was	be	AUX
ajst-10978	62	13	positively	positively	ADV
ajst-10978	62	14	correlated	correlate	VERB
ajst-10978	62	15	with	with	ADP
ajst-10978	62	16	pd-1	pd-1	ADJ
ajst-10978	62	17	and	and	CCONJ
ajst-10978	62	18	pd	pd	PROPN
ajst-10978	62	19	-	-	PROPN
ajst-10978	62	20	l1	l1	PROPN
ajst-10978	62	21	.	.	PUNCT
ajst-10978	63	1	more	more	ADV
ajst-10978	63	2	importantly	importantly	ADV
ajst-10978	63	3	,	,	PUNCT
ajst-10978	63	4	stat1	stat1	X
ajst-10978	63	5	co	co	NOUN
ajst-10978	63	6	-	-	NOUN
ajst-10978	63	7	expression	expression	NOUN
ajst-10978	63	8	with	with	ADP
ajst-10978	63	9	pd	pd	PROPN
ajst-10978	63	10	-	-	PROPN
ajst-10978	63	11	l1	l1	PROPN
ajst-10978	63	12	and	and	CCONJ
ajst-10978	63	13	pd-1	pd-1	ADV
ajst-10978	63	14	also	also	ADV
ajst-10978	63	15	predicted	predict	VERB
ajst-10978	63	16	os	os	NOUN
ajst-10978	63	17	in	in	ADP
ajst-10978	63	18	bc	bc	PROPN
ajst-10978	63	19	patients	patient	NOUN
ajst-10978	63	20	.	.	PUNCT
ajst-10978	64	1	in	in	ADP
ajst-10978	64	2	addition	addition	NOUN
ajst-10978	64	3	,	,	PUNCT
ajst-10978	64	4	stat1	stat1	PROPN
ajst-10978	64	5	was	be	AUX
ajst-10978	64	6	overexpressed	overexpresse	VERB
ajst-10978	64	7	in	in	ADP
ajst-10978	64	8	bc	bc	PROPN
ajst-10978	64	9	patients	patient	NOUN
ajst-10978	64	10	regardless	regardless	ADV
ajst-10978	64	11	of	of	ADP
ajst-10978	64	12	type	type	NOUN
ajst-10978	64	13	.	.	PUNCT
ajst-10978	65	1	these	these	DET
ajst-10978	65	2	findings	finding	NOUN
ajst-10978	65	3	may	may	AUX
ajst-10978	65	4	provide	provide	VERB
ajst-10978	65	5	accurate	accurate	ADJ
ajst-10978	65	6	and	and	CCONJ
ajst-10978	65	7	valuable	valuable	ADJ
ajst-10978	65	8	os	os	NOUN
ajst-10978	65	9	prediction	prediction	NOUN
ajst-10978	65	10	for	for	ADP
ajst-10978	65	11	bc	bc	PROPN
ajst-10978	65	12	.	.	PROPN
ajst-10978	66	1	on	on	ADP
ajst-10978	66	2	the	the	DET
ajst-10978	66	3	basis	basis	NOUN
ajst-10978	66	4	of	of	ADP
ajst-10978	66	5	molecular	molecular	ADJ
ajst-10978	66	6	typing	typing	NOUN
ajst-10978	66	7	,	,	PUNCT
ajst-10978	66	8	basal	basal	NOUN
ajst-10978	66	9	-	-	PUNCT
ajst-10978	66	10	like	like	ADJ
ajst-10978	66	11	bc	bc	PROPN
ajst-10978	66	12	subtype	subtype	NOUN
ajst-10978	66	13	showed	show	VERB
ajst-10978	66	14	highest	high	ADJ
ajst-10978	66	15	expression	expression	NOUN
ajst-10978	66	16	of	of	ADP
ajst-10978	66	17	stat1	stat1	PROPN
ajst-10978	66	18	,	,	PUNCT
ajst-10978	66	19	ido1	ido1	PROPN
ajst-10978	66	20	,	,	PUNCT
ajst-10978	66	21	lag3	lag3	PROPN
ajst-10978	66	22	,	,	PUNCT
ajst-10978	66	23	which	which	PRON
ajst-10978	66	24	suggest	suggest	VERB
ajst-10978	66	25	that	that	SCONJ
ajst-10978	66	26	different	different	ADJ
ajst-10978	66	27	subtypes	subtype	NOUN
ajst-10978	66	28	possess	possess	VERB
ajst-10978	66	29	various	various	ADJ
ajst-10978	66	30	immune	immune	ADJ
ajst-10978	66	31	checkpoints	checkpoint	NOUN
ajst-10978	66	32	status	status	NOUN
ajst-10978	66	33	.	.	PUNCT
ajst-10978	67	1	in	in	ADP
ajst-10978	67	2	addition	addition	NOUN
ajst-10978	67	3	,	,	PUNCT
ajst-10978	67	4	the	the	DET
ajst-10978	67	5	expression	expression	NOUN
ajst-10978	67	6	of	of	ADP
ajst-10978	67	7	pd-1	pd-1	ADJ
ajst-10978	67	8	and	and	CCONJ
ajst-10978	67	9	pd	pd	PROPN
ajst-10978	67	10	-	-	PROPN
ajst-10978	67	11	l1	l1	PROPN
ajst-10978	67	12	was	be	AUX
ajst-10978	67	13	associated	associate	VERB
ajst-10978	67	14	with	with	ADP
ajst-10978	67	15	recurrence	recurrence	NOUN
ajst-10978	67	16	and	and	CCONJ
ajst-10978	67	17	difficulty	difficulty	NOUN
ajst-10978	67	18	in	in	ADP
ajst-10978	67	19	bc	bc	PROPN
ajst-10978	67	20	patients	patient	NOUN
ajst-10978	67	21	[	[	X
ajst-10978	67	22	32	32	NUM
ajst-10978	67	23	]	]	PUNCT
ajst-10978	67	24	.	.	PUNCT
ajst-10978	68	1	both	both	DET
ajst-10978	68	2	pd-1	pd-1	ADJ
ajst-10978	68	3	and	and	CCONJ
ajst-10978	68	4	ido	ido	NOUN
ajst-10978	68	5	are	be	AUX
ajst-10978	68	6	highly	highly	ADV
ajst-10978	68	7	expressed	express	VERB
ajst-10978	68	8	in	in	ADP
ajst-10978	68	9	the	the	DET
ajst-10978	68	10	tumor	tumor	NOUN
ajst-10978	68	11	microenvironment	microenvironment	NOUN
ajst-10978	68	12	of	of	ADP
ajst-10978	68	13	bc	bc	PROPN
ajst-10978	68	14	patients	patient	NOUN
ajst-10978	68	15	,	,	PUNCT
ajst-10978	68	16	while	while	SCONJ
ajst-10978	68	17	lag3	lag3	PROPN
ajst-10978	68	18	and	and	CCONJ
ajst-10978	68	19	pd-1	pd-1	ADV
ajst-10978	68	20	were	be	AUX
ajst-10978	68	21	highly	highly	ADV
ajst-10978	68	22	expressed	express	VERB
ajst-10978	68	23	in	in	ADP
ajst-10978	68	24	t	t	PROPN
ajst-10978	68	25	cells	cell	NOUN
ajst-10978	68	26	of	of	ADP
ajst-10978	68	27	bc	bc	PROPN
ajst-10978	68	28	patients	patient	NOUN
ajst-10978	68	29	,	,	PUNCT
ajst-10978	68	30	suggesting	suggest	VERB
ajst-10978	68	31	poor	poor	ADJ
ajst-10978	68	32	prognosis	prognosis	NOUN
ajst-10978	68	33	[	[	X
ajst-10978	68	34	33	33	NUM
ajst-10978	68	35	,	,	PUNCT
ajst-10978	68	36	34	34	NUM
ajst-10978	68	37	]	]	PUNCT
ajst-10978	68	38	.	.	PUNCT
ajst-10978	69	1	which	which	PRON
ajst-10978	69	2	not	not	PART
ajst-10978	69	3	only	only	ADV
ajst-10978	69	4	confirm	confirm	VERB
ajst-10978	69	5	the	the	DET
ajst-10978	69	6	critical	critical	ADJ
ajst-10978	69	7	role	role	NOUN
ajst-10978	69	8	of	of	ADP
ajst-10978	69	9	immune	immune	ADJ
ajst-10978	69	10	checkpoint	checkpoint	NOUN
ajst-10978	69	11	in	in	ADP
ajst-10978	69	12	bc	bc	PROPN
ajst-10978	69	13	progression	progression	NOUN
ajst-10978	69	14	and	and	CCONJ
ajst-10978	69	15	prognosis	prognosis	NOUN
ajst-10978	69	16	,	,	PUNCT
ajst-10978	69	17	but	but	CCONJ
ajst-10978	69	18	also	also	ADV
ajst-10978	69	19	associated	associate	VERB
ajst-10978	69	20	with	with	ADP
ajst-10978	69	21	immune	immune	ADJ
ajst-10978	69	22	evasion	evasion	NOUN
ajst-10978	69	23	in	in	ADP
ajst-10978	69	24	numerous	numerous	ADJ
ajst-10978	69	25	.	.	PUNCT
ajst-10978	70	1	especially	especially	ADV
ajst-10978	70	2	in	in	ADP
ajst-10978	70	3	tnbc	tnbc	NOUN
ajst-10978	70	4	,	,	PUNCT
ajst-10978	70	5	pd	pd	PROPN
ajst-10978	70	6	-	-	PROPN
ajst-10978	70	7	l1	l1	PROPN
ajst-10978	70	8	and	and	CCONJ
ajst-10978	70	9	stat1	stat1	NOUN
ajst-10978	70	10	are	be	AUX
ajst-10978	70	11	both	both	PRON
ajst-10978	70	12	highly	highly	ADV
ajst-10978	70	13	expressed	express	VERB
ajst-10978	70	14	,	,	PUNCT
ajst-10978	70	15	while	while	SCONJ
ajst-10978	70	16	in	in	ADP
ajst-10978	70	17	conventional	conventional	ADJ
ajst-10978	70	18	bc	bc	PROPN
ajst-10978	70	19	,	,	PUNCT
ajst-10978	70	20	pd	pd	PROPN
ajst-10978	70	21	-	-	PROPN
ajst-10978	70	22	l1	l1	PROPN
ajst-10978	70	23	and	and	CCONJ
ajst-10978	70	24	stat1	stat1	NOUN
ajst-10978	70	25	are	be	AUX
ajst-10978	70	26	simultaneously	simultaneously	ADV
ajst-10978	70	27	low	low	ADJ
ajst-10978	70	28	expressed	express	VERB
ajst-10978	70	29	,	,	PUNCT
ajst-10978	70	30	which	which	PRON
ajst-10978	70	31	may	may	AUX
ajst-10978	70	32	be	be	AUX
ajst-10978	70	33	related	relate	VERB
ajst-10978	70	34	to	to	ADP
ajst-10978	70	35	the	the	DET
ajst-10978	70	36	poor	poor	ADJ
ajst-10978	70	37	treatment	treatment	NOUN
ajst-10978	70	38	of	of	ADP
ajst-10978	70	39	pd	pd	PROPN
ajst-10978	70	40	-	-	PUNCT
ajst-10978	70	41	l1	l1	PROPN
ajst-10978	70	42	/	/	SYM
ajst-10978	70	43	pd-1	pd-1	ADJ
ajst-10978	70	44	inhibitors	inhibitor	NOUN
ajst-10978	70	45	in	in	ADP
ajst-10978	70	46	some	some	DET
ajst-10978	70	47	bc	bc	PROPN
ajst-10978	70	48	.	.	PUNCT
ajst-10978	71	1	surprisingly	surprisingly	ADV
ajst-10978	71	2	,	,	PUNCT
ajst-10978	71	3	pd	pd	PROPN
ajst-10978	71	4	-	-	PROPN
ajst-10978	71	5	l1	l1	PROPN
ajst-10978	71	6	and	and	CCONJ
ajst-10978	71	7	stat1	stat1	NOUN
ajst-10978	71	8	are	be	AUX
ajst-10978	71	9	also	also	ADV
ajst-10978	71	10	overexpressed	overexpresse	VERB
ajst-10978	71	11	in	in	ADP
ajst-10978	71	12	precancerous	precancerous	ADJ
ajst-10978	71	13	breast	breast	NOUN
ajst-10978	71	14	cancer	cancer	NOUN
ajst-10978	71	15	cells	cell	NOUN
ajst-10978	71	16	.	.	PUNCT
ajst-10978	72	1	this	this	PRON
ajst-10978	72	2	suggests	suggest	VERB
ajst-10978	72	3	that	that	SCONJ
ajst-10978	72	4	the	the	DET
ajst-10978	72	5	expression	expression	NOUN
ajst-10978	72	6	of	of	ADP
ajst-10978	72	7	immune	immune	ADJ
ajst-10978	72	8	checkpoint	checkpoint	NOUN
ajst-10978	72	9	may	may	AUX
ajst-10978	72	10	be	be	AUX
ajst-10978	72	11	different	different	ADJ
ajst-10978	72	12	in	in	ADP
ajst-10978	72	13	different	different	ADJ
ajst-10978	72	14	subtypes	subtype	NOUN
ajst-10978	72	15	of	of	ADP
ajst-10978	72	16	breast	breast	NOUN
ajst-10978	72	17	cancer	cancer	NOUN
ajst-10978	72	18	or	or	CCONJ
ajst-10978	72	19	precancerous	precancerous	ADJ
ajst-10978	72	20	lesions	lesion	NOUN
ajst-10978	72	21	.	.	PUNCT
ajst-10978	73	1	this	this	PRON
ajst-10978	73	2	may	may	AUX
ajst-10978	73	3	provide	provide	VERB
ajst-10978	73	4	a	a	DET
ajst-10978	73	5	new	new	ADJ
ajst-10978	73	6	direction	direction	NOUN
ajst-10978	73	7	for	for	ADP
ajst-10978	73	8	our	our	PRON
ajst-10978	73	9	treatment	treatment	NOUN
ajst-10978	73	10	strategy	strategy	NOUN
ajst-10978	73	11	.	.	PUNCT
ajst-10978	74	1	as	as	SCONJ
ajst-10978	74	2	is	be	AUX
ajst-10978	74	3	known	know	VERB
ajst-10978	74	4	to	to	ADP
ajst-10978	74	5	all	all	PRON
ajst-10978	74	6	,	,	PUNCT
ajst-10978	74	7	the	the	DET
ajst-10978	74	8	research	research	NOUN
ajst-10978	74	9	of	of	ADP
ajst-10978	74	10	immune	immune	ADJ
ajst-10978	74	11	checkpoint	checkpoint	NOUN
ajst-10978	74	12	is	be	AUX
ajst-10978	74	13	becoming	become	VERB
ajst-10978	74	14	more	more	ADV
ajst-10978	74	15	and	and	CCONJ
ajst-10978	74	16	more	more	ADV
ajst-10978	74	17	important	important	ADJ
ajst-10978	74	18	in	in	ADP
ajst-10978	74	19	the	the	DET
ajst-10978	74	20	field	field	NOUN
ajst-10978	74	21	of	of	ADP
ajst-10978	74	22	cancer	cancer	NOUN
ajst-10978	74	23	.	.	PUNCT
ajst-10978	75	1	tumor	tumor	NOUN
ajst-10978	75	2	cells	cell	NOUN
ajst-10978	75	3	use	use	VERB
ajst-10978	75	4	various	various	ADJ
ajst-10978	75	5	tricks	trick	NOUN
ajst-10978	75	6	to	to	PART
ajst-10978	75	7	scape	scape	VERB
ajst-10978	75	8	of	of	ADP
ajst-10978	75	9	immune	immune	ADJ
ajst-10978	75	10	system	system	NOUN
ajst-10978	75	11	,	,	PUNCT
ajst-10978	75	12	such	such	ADJ
ajst-10978	75	13	as	as	ADP
ajst-10978	75	14	activating	activate	VERB
ajst-10978	75	15	immune	immune	ADJ
ajst-10978	75	16	checkpoint	checkpoint	NOUN
ajst-10978	75	17	pathways	pathway	NOUN
ajst-10978	75	18	that	that	PRON
ajst-10978	75	19	induce	induce	VERB
ajst-10978	75	20	immunosuppressive	immunosuppressive	ADJ
ajst-10978	75	21	function	function	NOUN
ajst-10978	75	22	.	.	PUNCT
ajst-10978	76	1	pd-1	pd-1	ADP
ajst-10978	76	2	and	and	CCONJ
ajst-10978	76	3	pd	pd	PROPN
ajst-10978	76	4	-	-	PUNCT
ajst-10978	76	5	l1	l1	PROPN
ajst-10978	76	6	,	,	PUNCT
ajst-10978	76	7	ctla-4	ctla-4	NOUN
ajst-10978	76	8	and	and	CCONJ
ajst-10978	76	9	lag3	lag3	NOUN
ajst-10978	76	10	have	have	AUX
ajst-10978	76	11	been	be	AUX
ajst-10978	76	12	extensively	extensively	ADV
ajst-10978	76	13	evaluated	evaluate	VERB
ajst-10978	76	14	as	as	ADP
ajst-10978	76	15	putative	putative	ADJ
ajst-10978	76	16	markers	marker	NOUN
ajst-10978	76	17	of	of	ADP
ajst-10978	76	18	response	response	NOUN
ajst-10978	76	19	to	to	ADP
ajst-10978	76	20	immunotherapy	immunotherapy	NOUN
ajst-10978	76	21	with	with	ADP
ajst-10978	76	22	pd-1	pd-1	ADP
ajst-10978	76	23	/	/	SYM
ajst-10978	76	24	pd	pd	NOUN
ajst-10978	76	25	-	-	PROPN
ajst-10978	76	26	l1	l1	PROPN
ajst-10978	76	27	and	and	CCONJ
ajst-10978	76	28	ctla-4	ctla-4	NOUN
ajst-10978	76	29	blockade	blockade	NOUN
ajst-10978	76	30	,	,	PUNCT
ajst-10978	76	31	respectively	respectively	ADV
ajst-10978	76	32	[	[	X
ajst-10978	76	33	35	35	NUM
ajst-10978	76	34	-	-	SYM
ajst-10978	76	35	38	38	NUM
ajst-10978	76	36	]	]	PUNCT
ajst-10978	76	37	.	.	PUNCT
ajst-10978	77	1	abirami	abirami	PROPN
ajst-10978	77	2	et	et	PROPN
ajst-10978	77	3	al	al	PROPN
ajst-10978	77	4	.	.	PUNCT
ajst-10978	78	1	demonstrations	demonstration	NOUN
ajst-10978	78	2	of	of	ADP
ajst-10978	78	3	clinical	clinical	ADJ
ajst-10978	78	4	benefit	benefit	NOUN
ajst-10978	78	5	of	of	ADP
ajst-10978	78	6	immunotherapy	immunotherapy	NOUN
ajst-10978	78	7	in	in	ADP
ajst-10978	78	8	female	female	ADJ
ajst-10978	78	9	metastatic	metastatic	ADJ
ajst-10978	78	10	breast	breast	NOUN
ajst-10978	78	11	cancers	cancer	NOUN
ajst-10978	78	12	(	(	PUNCT
ajst-10978	78	13	mbc	mbc	PROPN
ajst-10978	78	14	)	)	PUNCT
ajst-10978	78	15	support	support	VERB
ajst-10978	78	16	the	the	DET
ajst-10978	78	17	need	need	NOUN
ajst-10978	78	18	for	for	ADP
ajst-10978	78	19	development	development	NOUN
ajst-10978	78	20	and	and	CCONJ
ajst-10978	78	21	utilization	utilization	NOUN
ajst-10978	78	22	of	of	ADP
ajst-10978	78	23	biomarkers	biomarker	NOUN
ajst-10978	78	24	to	to	PART
ajst-10978	78	25	guide	guide	VERB
ajst-10978	78	26	the	the	DET
ajst-10978	78	27	use	use	NOUN
ajst-10978	78	28	of	of	ADP
ajst-10978	78	29	immune	immune	ADJ
ajst-10978	78	30	checkpoint	checkpoint	NOUN
ajst-10978	78	31	inhibitors	inhibitor	NOUN
ajst-10978	78	32	(	(	PUNCT
ajst-10978	78	33	icpis	icpis	NOUN
ajst-10978	78	34	)	)	PUNCT
ajst-10978	78	35	for	for	ADP
ajst-10978	78	36	these	these	DET
ajst-10978	78	37	patients	patient	NOUN
ajst-10978	78	38	,	,	PUNCT
ajst-10978	78	39	such	such	ADJ
ajst-10978	78	40	as	as	ADP
ajst-10978	78	41	pd1	pd1	NOUN
ajst-10978	78	42	,	,	PUNCT
ajst-10978	78	43	pd	pd	PROPN
ajst-10978	78	44	-	-	PUNCT
ajst-10978	78	45	l1	l1	PROPN
ajst-10978	78	46	,	,	PUNCT
ajst-10978	78	47	ctla-4	ctla-4	NOUN
ajst-10978	78	48	and	and	CCONJ
ajst-10978	78	49	lag3	lag3	NOUN
ajst-10978	79	1	[	[	X
ajst-10978	79	2	39	39	NUM
ajst-10978	79	3	]	]	PUNCT
ajst-10978	79	4	.	.	PUNCT
ajst-10978	80	1	in	in	ADP
ajst-10978	80	2	this	this	DET
ajst-10978	80	3	study	study	NOUN
ajst-10978	80	4	,	,	PUNCT
ajst-10978	80	5	both	both	PRON
ajst-10978	80	6	pd-1	pd-1	ADJ
ajst-10978	80	7	and	and	CCONJ
ajst-10978	80	8	pd	pd	PROPN
ajst-10978	80	9	-	-	PROPN
ajst-10978	80	10	l1	l1	PROPN
ajst-10978	80	11	were	be	AUX
ajst-10978	80	12	positively	positively	ADV
ajst-10978	80	13	correlated	correlate	VERB
ajst-10978	80	14	with	with	ADP
ajst-10978	80	15	stat1	stat1	NOUN
ajst-10978	80	16	expression	expression	NOUN
ajst-10978	80	17	.	.	PUNCT
ajst-10978	81	1	although	although	SCONJ
ajst-10978	81	2	not	not	PART
ajst-10978	81	3	associated	associate	VERB
ajst-10978	81	4	with	with	ADP
ajst-10978	81	5	short	short	ADJ
ajst-10978	81	6	-	-	PUNCT
ajst-10978	81	7	term	term	NOUN
ajst-10978	81	8	survival	survival	NOUN
ajst-10978	81	9	outcomes	outcome	NOUN
ajst-10978	81	10	,	,	PUNCT
ajst-10978	81	11	it	it	PRON
ajst-10978	81	12	is	be	AUX
ajst-10978	81	13	significant	significant	ADJ
ajst-10978	81	14	for	for	ADP
ajst-10978	81	15	long	long	ADJ
ajst-10978	81	16	-	-	PUNCT
ajst-10978	81	17	term	term	NOUN
ajst-10978	81	18	survival	survival	NOUN
ajst-10978	81	19	,	,	PUNCT
ajst-10978	81	20	especially	especially	ADV
ajst-10978	81	21	for	for	ADP
ajst-10978	81	22	pd-1	pd-1	ADJ
ajst-10978	81	23	expression	expression	NOUN
ajst-10978	81	24	and	and	CCONJ
ajst-10978	81	25	co	co	NOUN
ajst-10978	81	26	-	-	NOUN
ajst-10978	81	27	expression	expression	ADJ
ajst-10978	81	28	pd	pd	PROPN
ajst-10978	81	29	-	-	PROPN
ajst-10978	81	30	l1	l1	PROPN
ajst-10978	81	31	or	or	CCONJ
ajst-10978	81	32	stat1	stat1	NOUN
ajst-10978	81	33	expression	expression	NOUN
ajst-10978	81	34	.	.	PUNCT
ajst-10978	82	1	this	this	PRON
ajst-10978	82	2	may	may	AUX
ajst-10978	82	3	be	be	AUX
ajst-10978	82	4	due	due	ADJ
ajst-10978	82	5	to	to	ADP
ajst-10978	82	6	inconsistencies	inconsistency	NOUN
ajst-10978	82	7	in	in	ADP
ajst-10978	82	8	the	the	DET
ajst-10978	82	9	subtypes	subtype	NOUN
ajst-10978	82	10	of	of	ADP
ajst-10978	82	11	bc	bc	PROPN
ajst-10978	82	12	.	.	PROPN
ajst-10978	83	1	in	in	ADP
ajst-10978	83	2	addition	addition	NOUN
ajst-10978	83	3	,	,	PUNCT
ajst-10978	83	4	we	we	PRON
ajst-10978	83	5	observed	observe	VERB
ajst-10978	83	6	that	that	SCONJ
ajst-10978	83	7	pd	pd	PROPN
ajst-10978	83	8	-	-	PROPN
ajst-10978	83	9	l1	l1	PROPN
ajst-10978	83	10	was	be	AUX
ajst-10978	83	11	more	more	ADV
ajst-10978	83	12	expressed	express	VERB
ajst-10978	83	13	in	in	ADP
ajst-10978	83	14	tnbc	tnbc	NOUN
ajst-10978	83	15	.	.	PUNCT
ajst-10978	84	1	therefore	therefore	ADV
ajst-10978	84	2	,	,	PUNCT
ajst-10978	84	3	in	in	ADP
ajst-10978	84	4	the	the	DET
ajst-10978	84	5	near	near	ADJ
ajst-10978	84	6	future	future	NOUN
ajst-10978	84	7	,	,	PUNCT
ajst-10978	84	8	the	the	DET
ajst-10978	84	9	application	application	NOUN
ajst-10978	84	10	of	of	ADP
ajst-10978	84	11	molecular	molecular	ADJ
ajst-10978	84	12	and	and	CCONJ
ajst-10978	84	13	biochemical	biochemical	ADJ
ajst-10978	84	14	markers	marker	NOUN
ajst-10978	84	15	in	in	ADP
ajst-10978	84	16	a	a	DET
ajst-10978	84	17	personalized	personalize	VERB
ajst-10978	84	18	manner	manner	NOUN
ajst-10978	84	19	will	will	AUX
ajst-10978	84	20	improve	improve	VERB
ajst-10978	84	21	optimal	optimal	ADJ
ajst-10978	84	22	combination	combination	NOUN
ajst-10978	84	23	immunotherapy	immunotherapy	NOUN
ajst-10978	84	24	,	,	PUNCT
ajst-10978	84	25	providing	provide	VERB
ajst-10978	84	26	customized	customized	ADJ
ajst-10978	84	27	treatments	treatment	NOUN
ajst-10978	84	28	that	that	PRON
ajst-10978	84	29	may	may	AUX
ajst-10978	84	30	save	save	VERB
ajst-10978	84	31	the	the	DET
ajst-10978	84	32	lives	life	NOUN
ajst-10978	84	33	of	of	ADP
ajst-10978	84	34	patients	patient	NOUN
ajst-10978	84	35	with	with	ADP
ajst-10978	84	36	malignant	malignant	ADJ
ajst-10978	84	37	breast	breast	NOUN
ajst-10978	84	38	cancer	cancer	NOUN
ajst-10978	84	39	who	who	PRON
ajst-10978	84	40	have	have	VERB
ajst-10978	84	41	a	a	DET
ajst-10978	84	42	poor	poor	ADJ
ajst-10978	84	43	prognosis	prognosis	NOUN
ajst-10978	84	44	.	.	PUNCT
ajst-10978	85	1	4	4	X
ajst-10978	85	2	.	.	X
ajst-10978	85	3	conclusion	conclusion	NOUN
ajst-10978	85	4	in	in	ADP
ajst-10978	85	5	summary	summary	NOUN
ajst-10978	86	1	,	,	PUNCT
ajst-10978	86	2	we	we	PRON
ajst-10978	86	3	demonstrate	demonstrate	VERB
ajst-10978	86	4	that	that	SCONJ
ajst-10978	86	5	transcriptome	transcriptome	NOUN
ajst-10978	86	6	-	-	PUNCT
ajst-10978	86	7	based	base	VERB
ajst-10978	86	8	coexpression	coexpression	NOUN
ajst-10978	86	9	of	of	ADP
ajst-10978	86	10	stat1	stat1	NOUN
ajst-10978	86	11	and	and	CCONJ
ajst-10978	86	12	pd-1	pd-1	ADJ
ajst-10978	86	13	/	/	SYM
ajst-10978	86	14	pd	pd	NOUN
ajst-10978	86	15	-	-	PROPN
ajst-10978	86	16	l1	l1	PROPN
ajst-10978	86	17	could	could	AUX
ajst-10978	86	18	be	be	AUX
ajst-10978	86	19	a	a	DET
ajst-10978	86	20	predictor	predictor	NOUN
ajst-10978	86	21	of	of	ADP
ajst-10978	86	22	poor	poor	ADJ
ajst-10978	86	23	os	os	NOUN
ajst-10978	86	24	in	in	ADP
ajst-10978	86	25	bc	bc	PROPN
ajst-10978	86	26	patients	patient	NOUN
ajst-10978	86	27	.	.	PUNCT
ajst-10978	87	1	this	this	DET
ajst-10978	87	2	finding	finding	NOUN
ajst-10978	87	3	will	will	AUX
ajst-10978	87	4	provide	provide	VERB
ajst-10978	87	5	novel	novel	ADJ
ajst-10978	87	6	insights	insight	NOUN
ajst-10978	87	7	into	into	ADP
ajst-10978	87	8	designing	design	VERB
ajst-10978	87	9	combinational	combinational	ADJ
ajst-10978	87	10	immuno	immuno	ADJ
ajst-10978	87	11	-	-	PUNCT
ajst-10978	87	12	targeted	target	VERB
ajst-10978	87	13	therapy	therapy	NOUN
ajst-10978	87	14	in	in	ADP
ajst-10978	87	15	bc	bc	PROPN
ajst-10978	87	16	patients	patient	NOUN
ajst-10978	87	17	.	.	PUNCT
ajst-10978	88	1	7	7	NUM
ajst-10978	88	2	references	reference	NOUN
ajst-10978	88	3	[	[	X
ajst-10978	88	4	1	1	NUM
ajst-10978	88	5	]	]	PUNCT
ajst-10978	88	6	topalian	topalian	NOUN
ajst-10978	88	7	sl	sl	PROPN
ajst-10978	88	8	,	,	PUNCT
ajst-10978	88	9	drake	drake	PROPN
ajst-10978	88	10	cg	cg	PROPN
ajst-10978	88	11	,	,	PUNCT
ajst-10978	88	12	pardoll	pardoll	PROPN
ajst-10978	88	13	dm	dm	PROPN
ajst-10978	88	14	.	.	PROPN
ajst-10978	88	15	immune	immune	ADJ
ajst-10978	88	16	checkpoint	checkpoint	NOUN
ajst-10978	88	17	blockade	blockade	NOUN
ajst-10978	88	18	:	:	PUNCT
ajst-10978	88	19	a	a	DET
ajst-10978	88	20	common	common	ADJ
ajst-10978	88	21	denominator	denominator	NOUN
ajst-10978	88	22	approach	approach	NOUN
ajst-10978	88	23	to	to	ADP
ajst-10978	88	24	cancer	cancer	NOUN
ajst-10978	88	25	therapy	therapy	NOUN
ajst-10978	88	26	.	.	PUNCT
ajst-10978	89	1	cancer	cancer	NOUN
ajst-10978	89	2	cell	cell	NOUN
ajst-10978	89	3	.	.	PUNCT
ajst-10978	90	1	2015	2015	NUM
ajst-10978	90	2	;	;	PUNCT
ajst-10978	90	3	27:450	27:450	NUM
ajst-10978	90	4	-	-	SYM
ajst-10978	90	5	461	461	NUM
ajst-10978	90	6	.	.	PUNCT
ajst-10978	91	1	[	[	X
ajst-10978	91	2	2	2	NUM
ajst-10978	91	3	]	]	PUNCT
ajst-10978	91	4	iwai	iwai	PROPN
ajst-10978	91	5	y	y	PROPN
ajst-10978	91	6	,	,	PUNCT
ajst-10978	91	7	ishida	ishida	PROPN
ajst-10978	91	8	m	m	PROPN
ajst-10978	91	9	,	,	PUNCT
ajst-10978	91	10	tanaka	tanaka	PROPN
ajst-10978	91	11	y	y	PROPN
ajst-10978	91	12	,	,	PUNCT
ajst-10978	91	13	okazaki	okazaki	PROPN
ajst-10978	91	14	t	t	PROPN
ajst-10978	91	15	,	,	PUNCT
ajst-10978	91	16	honjo	honjo	PROPN
ajst-10978	91	17	t	t	PROPN
ajst-10978	91	18	,	,	PUNCT
ajst-10978	91	19	minato	minato	PROPN
ajst-10978	91	20	n.	n.	PROPN
ajst-10978	91	21	involvement	involvement	NOUN
ajst-10978	91	22	of	of	ADP
ajst-10978	91	23	pd	pd	PROPN
ajst-10978	91	24	-	-	PROPN
ajst-10978	91	25	l1	l1	PROPN
ajst-10978	91	26	on	on	ADP
ajst-10978	91	27	tumor	tumor	NOUN
ajst-10978	91	28	cells	cell	NOUN
ajst-10978	91	29	in	in	ADP
ajst-10978	91	30	the	the	DET
ajst-10978	91	31	escape	escape	NOUN
ajst-10978	91	32	from	from	ADP
ajst-10978	91	33	host	host	NOUN
ajst-10978	91	34	immune	immune	ADJ
ajst-10978	91	35	system	system	NOUN
ajst-10978	91	36	and	and	CCONJ
ajst-10978	91	37	tumor	tumor	NOUN
ajst-10978	91	38	immunotherapy	immunotherapy	NOUN
ajst-10978	91	39	by	by	ADP
ajst-10978	91	40	pd	pd	PROPN
ajst-10978	91	41	-	-	PROPN
ajst-10978	91	42	l1	l1	PROPN
ajst-10978	91	43	blockade	blockade	NOUN
ajst-10978	91	44	.	.	PUNCT
ajst-10978	92	1	proceedings	proceeding	NOUN
ajst-10978	92	2	of	of	ADP
ajst-10978	92	3	the	the	DET
ajst-10978	92	4	national	national	PROPN
ajst-10978	92	5	academy	academy	PROPN
ajst-10978	92	6	of	of	ADP
ajst-10978	92	7	sciences	sciences	PROPN
ajst-10978	92	8	of	of	ADP
ajst-10978	92	9	the	the	DET
ajst-10978	92	10	united	united	PROPN
ajst-10978	92	11	states	states	PROPN
ajst-10978	92	12	of	of	ADP
ajst-10978	92	13	america	america	PROPN
ajst-10978	92	14	.	.	PUNCT
ajst-10978	93	1	2002	2002	NUM
ajst-10978	93	2	;	;	PUNCT
ajst-10978	93	3	99:12293	99:12293	NUM
ajst-10978	93	4	-	-	SYM
ajst-10978	93	5	12297	12297	NUM
ajst-10978	93	6	.	.	PUNCT
ajst-10978	94	1	[	[	X
ajst-10978	94	2	3	3	X
ajst-10978	94	3	]	]	X
ajst-10978	94	4	muller	muller	NOUN
ajst-10978	94	5	p	p	NOUN
ajst-10978	94	6	,	,	PUNCT
ajst-10978	94	7	kreuzaler	kreuzaler	NOUN
ajst-10978	94	8	m	m	PROPN
ajst-10978	94	9	,	,	PUNCT
ajst-10978	94	10	khan	khan	PROPN
ajst-10978	94	11	t	t	PROPN
ajst-10978	94	12	,	,	PUNCT
ajst-10978	94	13	thommen	thommen	PROPN
ajst-10978	94	14	ds	ds	PROPN
ajst-10978	94	15	,	,	PUNCT
ajst-10978	94	16	martin	martin	PROPN
ajst-10978	94	17	k	k	PROPN
ajst-10978	94	18	,	,	PUNCT
ajst-10978	94	19	glatz	glatz	VERB
ajst-10978	94	20	k	k	PROPN
ajst-10978	94	21	,	,	PUNCT
ajst-10978	94	22	et	et	PROPN
ajst-10978	94	23	al	al	PROPN
ajst-10978	94	24	.	.	PROPN
ajst-10978	94	25	trastuzumab	trastuzumab	NOUN
ajst-10978	94	26	emtansine	emtansine	PROPN
ajst-10978	94	27	(	(	PUNCT
ajst-10978	94	28	t	t	PROPN
ajst-10978	94	29	-	-	PUNCT
ajst-10978	94	30	dm1	dm1	NOUN
ajst-10978	94	31	)	)	PUNCT
ajst-10978	94	32	renders	render	VERB
ajst-10978	94	33	her2(+	her2(+	NOUN
ajst-10978	94	34	)	)	PUNCT
ajst-10978	94	35	breast	breast	NOUN
ajst-10978	94	36	cancer	cancer	NOUN
ajst-10978	94	37	highly	highly	ADV
ajst-10978	94	38	susceptible	susceptible	ADJ
ajst-10978	94	39	to	to	ADP
ajst-10978	94	40	ctla-4	ctla-4	NUM
ajst-10978	94	41	/	/	SYM
ajst-10978	94	42	pd-1	pd-1	NOUN
ajst-10978	94	43	blockade	blockade	NOUN
ajst-10978	94	44	.	.	PUNCT
ajst-10978	95	1	science	science	NOUN
ajst-10978	95	2	translational	translational	ADJ
ajst-10978	95	3	medicine	medicine	NOUN
ajst-10978	95	4	.	.	PUNCT
ajst-10978	96	1	2015	2015	NUM
ajst-10978	96	2	;	;	PUNCT
ajst-10978	96	3	7	7	X
ajst-10978	96	4	.	.	PUNCT
ajst-10978	97	1	[	[	X
ajst-10978	97	2	4	4	X
ajst-10978	97	3	]	]	X
ajst-10978	97	4	parra	parra	PROPN
ajst-10978	97	5	k	k	PROPN
ajst-10978	97	6	,	,	PUNCT
ajst-10978	97	7	valenzuela	valenzuela	PROPN
ajst-10978	97	8	p	p	PROPN
ajst-10978	97	9	,	,	PUNCT
ajst-10978	97	10	lerma	lerma	PROPN
ajst-10978	97	11	n	n	CCONJ
ajst-10978	97	12	,	,	PUNCT
ajst-10978	97	13	gallegos	gallegos	PROPN
ajst-10978	97	14	a	a	DET
ajst-10978	97	15	,	,	PUNCT
ajst-10978	97	16	reza	reza	PROPN
ajst-10978	97	17	lc	lc	PROPN
ajst-10978	97	18	,	,	PUNCT
ajst-10978	97	19	rodriguez	rodriguez	PROPN
ajst-10978	97	20	g	g	PROPN
ajst-10978	97	21	,	,	PUNCT
ajst-10978	97	22	et	et	PROPN
ajst-10978	97	23	al	al	PROPN
ajst-10978	97	24	.	.	PROPN
ajst-10978	97	25	impact	impact	NOUN
ajst-10978	97	26	of	of	ADP
ajst-10978	97	27	ctla-4	ctla-4	NUM
ajst-10978	97	28	blockade	blockade	NOUN
ajst-10978	97	29	in	in	ADP
ajst-10978	97	30	conjunction	conjunction	NOUN
ajst-10978	97	31	with	with	ADP
ajst-10978	97	32	metronomic	metronomic	ADJ
ajst-10978	97	33	chemotherapy	chemotherapy	NOUN
ajst-10978	97	34	on	on	ADP
ajst-10978	97	35	preclinical	preclinical	ADJ
ajst-10978	97	36	breast	breast	NOUN
ajst-10978	97	37	cancer	cancer	NOUN
ajst-10978	97	38	growth	growth	NOUN
ajst-10978	97	39	.	.	PUNCT
ajst-10978	98	1	british	british	ADJ
ajst-10978	98	2	journal	journal	PROPN
ajst-10978	98	3	of	of	ADP
ajst-10978	98	4	cancer	cancer	NOUN
ajst-10978	98	5	.	.	PUNCT
ajst-10978	99	1	2017	2017	NUM
ajst-10978	99	2	;	;	PUNCT
ajst-10978	99	3	116:324	116:324	PROPN
ajst-10978	99	4	-	-	PUNCT
ajst-10978	99	5	334	334	NUM
ajst-10978	99	6	.	.	PUNCT
ajst-10978	100	1	[	[	X
ajst-10978	100	2	5	5	X
ajst-10978	100	3	]	]	PUNCT
ajst-10978	100	4	muenst	muenst	PROPN
ajst-10978	100	5	s	s	PROPN
ajst-10978	100	6	,	,	PUNCT
ajst-10978	100	7	soysal	soysal	NOUN
ajst-10978	100	8	sd	sd	PROPN
ajst-10978	100	9	,	,	PUNCT
ajst-10978	100	10	gao	gao	PROPN
ajst-10978	100	11	f	f	PROPN
ajst-10978	100	12	,	,	PUNCT
ajst-10978	100	13	obermann	obermann	ADJ
ajst-10978	100	14	ec	ec	PROPN
ajst-10978	100	15	,	,	PUNCT
ajst-10978	100	16	oertli	oertli	PROPN
ajst-10978	100	17	d	d	PROPN
ajst-10978	100	18	,	,	PUNCT
ajst-10978	100	19	gillanders	gillander	NOUN
ajst-10978	100	20	we	we	PRON
ajst-10978	100	21	.	.	PUNCT
ajst-10978	101	1	the	the	DET
ajst-10978	101	2	presence	presence	NOUN
ajst-10978	101	3	of	of	ADP
ajst-10978	101	4	programmed	program	VERB
ajst-10978	101	5	death	death	NOUN
ajst-10978	101	6	1	1	NUM
ajst-10978	101	7	(	(	PUNCT
ajst-10978	101	8	pd-1)positive	pd-1)positive	ADJ
ajst-10978	101	9	tumor	tumor	NOUN
ajst-10978	101	10	-	-	PUNCT
ajst-10978	101	11	infiltrating	infiltrate	VERB
ajst-10978	101	12	lymphocytes	lymphocyte	NOUN
ajst-10978	101	13	is	be	AUX
ajst-10978	101	14	associated	associate	VERB
ajst-10978	101	15	with	with	ADP
ajst-10978	101	16	poor	poor	ADJ
ajst-10978	101	17	prognosis	prognosis	NOUN
ajst-10978	101	18	in	in	ADP
ajst-10978	101	19	human	human	ADJ
ajst-10978	101	20	breast	breast	NOUN
ajst-10978	101	21	cancer	cancer	NOUN
ajst-10978	101	22	.	.	PUNCT
ajst-10978	102	1	breast	breast	NOUN
ajst-10978	102	2	cancer	cancer	NOUN
ajst-10978	102	3	research	research	NOUN
ajst-10978	102	4	and	and	CCONJ
ajst-10978	102	5	treatment	treatment	NOUN
ajst-10978	102	6	.	.	PUNCT
ajst-10978	103	1	2013	2013	NUM
ajst-10978	103	2	;	;	PUNCT
ajst-10978	103	3	139:667	139:667	NOUN
ajst-10978	103	4	-	-	SYM
ajst-10978	103	5	676	676	NUM
ajst-10978	103	6	.	.	PUNCT
ajst-10978	104	1	[	[	X
ajst-10978	104	2	6	6	NUM
ajst-10978	104	3	]	]	PUNCT
ajst-10978	104	4	brahmer	brahmer	PROPN
ajst-10978	104	5	jr	jr	PROPN
ajst-10978	104	6	,	,	PUNCT
ajst-10978	104	7	tykodi	tykodi	PROPN
ajst-10978	104	8	ss	ss	PROPN
ajst-10978	104	9	,	,	PUNCT
ajst-10978	104	10	chow	chow	PROPN
ajst-10978	104	11	lqm	lqm	PROPN
ajst-10978	104	12	,	,	PUNCT
ajst-10978	104	13	hwu	hwu	PROPN
ajst-10978	104	14	wj	wj	NOUN
ajst-10978	104	15	,	,	PUNCT
ajst-10978	104	16	topalian	topalian	NOUN
ajst-10978	104	17	sl	sl	PROPN
ajst-10978	104	18	,	,	PUNCT
ajst-10978	104	19	hwu	hwu	VERB
ajst-10978	104	20	p	p	X
ajst-10978	104	21	,	,	PUNCT
ajst-10978	104	22	et	et	PROPN
ajst-10978	104	23	al	al	PROPN
ajst-10978	104	24	.	.	PROPN
ajst-10978	104	25	safety	safety	NOUN
ajst-10978	104	26	and	and	CCONJ
ajst-10978	104	27	activity	activity	NOUN
ajst-10978	104	28	of	of	ADP
ajst-10978	104	29	anti	anti	ADJ
ajst-10978	104	30	-	-	ADJ
ajst-10978	104	31	pd	pd	ADJ
ajst-10978	104	32	-	-	PUNCT
ajst-10978	104	33	l1	l1	PROPN
ajst-10978	104	34	antibody	antibody	NOUN
ajst-10978	104	35	in	in	ADP
ajst-10978	104	36	patients	patient	NOUN
ajst-10978	104	37	with	with	ADP
ajst-10978	104	38	advanced	advanced	ADJ
ajst-10978	104	39	cancer	cancer	NOUN
ajst-10978	104	40	.	.	PUNCT
ajst-10978	105	1	new	new	PROPN
ajst-10978	105	2	england	england	PROPN
ajst-10978	105	3	journal	journal	PROPN
ajst-10978	105	4	of	of	ADP
ajst-10978	105	5	medicine	medicine	NOUN
ajst-10978	105	6	.	.	PUNCT
ajst-10978	106	1	2012	2012	NUM
ajst-10978	106	2	;	;	PUNCT
ajst-10978	106	3	366:2455	366:2455	NUM
ajst-10978	106	4	-	-	SYM
ajst-10978	106	5	2465	2465	NUM
ajst-10978	106	6	.	.	PUNCT
ajst-10978	107	1	[	[	X
ajst-10978	107	2	7	7	NUM
ajst-10978	107	3	]	]	X
ajst-10978	107	4	topalian	topalian	NOUN
ajst-10978	107	5	sl	sl	PROPN
ajst-10978	107	6	,	,	PUNCT
ajst-10978	107	7	hodi	hodi	PROPN
ajst-10978	107	8	fs	fs	PROPN
ajst-10978	107	9	,	,	PUNCT
ajst-10978	107	10	brahmer	brahmer	PROPN
ajst-10978	107	11	jr	jr	PROPN
ajst-10978	107	12	,	,	PUNCT
ajst-10978	107	13	gettinger	gettinger	PROPN
ajst-10978	107	14	sn	sn	PROPN
ajst-10978	107	15	,	,	PUNCT
ajst-10978	107	16	smith	smith	PROPN
ajst-10978	107	17	dc	dc	PROPN
ajst-10978	107	18	,	,	PUNCT
ajst-10978	107	19	mcdermott	mcdermott	PROPN
ajst-10978	107	20	df	df	PROPN
ajst-10978	107	21	,	,	PUNCT
ajst-10978	107	22	et	et	PROPN
ajst-10978	107	23	al	al	PROPN
ajst-10978	107	24	.	.	PROPN
ajst-10978	107	25	safety	safety	PROPN
ajst-10978	107	26	,	,	PUNCT
ajst-10978	107	27	activity	activity	NOUN
ajst-10978	107	28	,	,	PUNCT
ajst-10978	107	29	and	and	CCONJ
ajst-10978	107	30	immune	immune	ADJ
ajst-10978	107	31	correlates	correlate	VERB
ajst-10978	107	32	of	of	ADP
ajst-10978	107	33	anti	anti	ADJ
ajst-10978	107	34	-	-	ADJ
ajst-10978	107	35	pd-1	pd-1	ADJ
ajst-10978	107	36	antibody	antibody	NOUN
ajst-10978	107	37	in	in	ADP
ajst-10978	107	38	cancer	cancer	NOUN
ajst-10978	107	39	.	.	PUNCT
ajst-10978	108	1	new	new	PROPN
ajst-10978	108	2	england	england	PROPN
ajst-10978	108	3	journal	journal	PROPN
ajst-10978	108	4	of	of	ADP
ajst-10978	108	5	medicine	medicine	NOUN
ajst-10978	108	6	.	.	PUNCT
ajst-10978	109	1	2012	2012	NUM
ajst-10978	109	2	;	;	PUNCT
ajst-10978	109	3	366:2443	366:2443	X
ajst-10978	109	4	-	-	SYM
ajst-10978	109	5	2454	2454	NUM
ajst-10978	109	6	.	.	PUNCT
ajst-10978	110	1	[	[	X
ajst-10978	110	2	8	8	NUM
ajst-10978	110	3	]	]	X
ajst-10978	110	4	bian	bian	PROPN
ajst-10978	110	5	l	l	PROPN
ajst-10978	110	6	,	,	PUNCT
ajst-10978	110	7	zhang	zhang	PROPN
ajst-10978	110	8	hq	hq	PROPN
ajst-10978	110	9	,	,	PUNCT
ajst-10978	110	10	wang	wang	PROPN
ajst-10978	110	11	t	t	PROPN
ajst-10978	110	12	,	,	PUNCT
ajst-10978	110	13	zhang	zhang	PROPN
ajst-10978	110	14	sh	sh	PROPN
ajst-10978	110	15	,	,	PUNCT
ajst-10978	110	16	song	song	NOUN
ajst-10978	110	17	hf	hf	PROPN
ajst-10978	110	18	,	,	PUNCT
ajst-10978	110	19	xu	xu	PROPN
ajst-10978	110	20	ml	ml	PROPN
ajst-10978	110	21	,	,	PUNCT
ajst-10978	110	22	et	et	PROPN
ajst-10978	110	23	al	al	PROPN
ajst-10978	110	24	.	.	PUNCT
ajst-10978	111	1	js001	js001	PROPN
ajst-10978	111	2	,	,	PUNCT
ajst-10978	111	3	an	an	DET
ajst-10978	111	4	anti	anti	ADJ
ajst-10978	111	5	-	-	ADJ
ajst-10978	111	6	pd-1	pd-1	ADJ
ajst-10978	111	7	mab	mab	NOUN
ajst-10978	111	8	for	for	ADP
ajst-10978	111	9	advanced	advanced	ADJ
ajst-10978	111	10	triple	triple	ADJ
ajst-10978	111	11	negative	negative	ADJ
ajst-10978	111	12	breast	breast	NOUN
ajst-10978	111	13	cancer	cancer	NOUN
ajst-10978	111	14	patients	patient	NOUN
ajst-10978	111	15	after	after	ADP
ajst-10978	111	16	multi	multi	ADJ
ajst-10978	111	17	-	-	ADJ
ajst-10978	111	18	line	line	ADJ
ajst-10978	111	19	systemic	systemic	ADJ
ajst-10978	111	20	therapy	therapy	NOUN
ajst-10978	111	21	in	in	ADP
ajst-10978	111	22	a	a	DET
ajst-10978	111	23	phase	phase	NOUN
ajst-10978	111	24	i	i	PRON
ajst-10978	111	25	trial	trial	NOUN
ajst-10978	111	26	.	.	PUNCT
ajst-10978	112	1	annals	annal	NOUN
ajst-10978	112	2	of	of	ADP
ajst-10978	112	3	translational	translational	ADJ
ajst-10978	112	4	medicine	medicine	NOUN
ajst-10978	112	5	.	.	PUNCT
ajst-10978	113	1	2019	2019	NUM
ajst-10978	113	2	;	;	PUNCT
ajst-10978	113	3	7	7	X
ajst-10978	113	4	.	.	PUNCT
ajst-10978	114	1	[	[	X
ajst-10978	114	2	9	9	NUM
ajst-10978	114	3	]	]	PUNCT
ajst-10978	114	4	jiang	jiang	PROPN
ajst-10978	114	5	c	c	PROPN
ajst-10978	114	6	,	,	PUNCT
ajst-10978	114	7	cao	cao	PROPN
ajst-10978	114	8	sr	sr	PROPN
ajst-10978	114	9	,	,	PUNCT
ajst-10978	114	10	li	li	PROPN
ajst-10978	114	11	n	n	PROPN
ajst-10978	114	12	,	,	PUNCT
ajst-10978	114	13	jiang	jiang	PROPN
ajst-10978	114	14	l	l	PROPN
ajst-10978	114	15	,	,	PUNCT
ajst-10978	114	16	sun	sun	PROPN
ajst-10978	114	17	t.	t.	PROPN
ajst-10978	114	18	pd-1	pd-1	ADJ
ajst-10978	114	19	and	and	CCONJ
ajst-10978	114	20	pd	pd	PROPN
ajst-10978	114	21	-	-	PUNCT
ajst-10978	114	22	l1	l1	PROPN
ajst-10978	114	23	correlated	correlate	VERB
ajst-10978	114	24	gene	gene	NOUN
ajst-10978	114	25	expression	expression	NOUN
ajst-10978	114	26	profiles	profile	NOUN
ajst-10978	114	27	and	and	CCONJ
ajst-10978	114	28	their	their	PRON
ajst-10978	114	29	association	association	NOUN
ajst-10978	114	30	with	with	ADP
ajst-10978	114	31	clinical	clinical	ADJ
ajst-10978	114	32	outcomes	outcome	NOUN
ajst-10978	114	33	of	of	ADP
ajst-10978	114	34	breast	breast	NOUN
ajst-10978	114	35	cancer	cancer	NOUN
ajst-10978	114	36	.	.	PUNCT
ajst-10978	115	1	cancer	cancer	NOUN
ajst-10978	115	2	cell	cell	NOUN
ajst-10978	115	3	international	international	ADJ
ajst-10978	115	4	.	.	PUNCT
ajst-10978	116	1	2019	2019	NUM
ajst-10978	116	2	;	;	PUNCT
ajst-10978	116	3	19	19	NUM
ajst-10978	116	4	.	.	PUNCT
ajst-10978	117	1	[	[	X
ajst-10978	117	2	10	10	NUM
ajst-10978	117	3	]	]	X
ajst-10978	117	4	zielinski	zielinski	PROPN
ajst-10978	117	5	c	c	PROPN
ajst-10978	117	6	,	,	PUNCT
ajst-10978	117	7	knapp	knapp	PROPN
ajst-10978	117	8	s	s	PROPN
ajst-10978	117	9	,	,	PUNCT
ajst-10978	117	10	mascaux	mascaux	PROPN
ajst-10978	117	11	c	c	PROPN
ajst-10978	117	12	,	,	PUNCT
ajst-10978	117	13	hirsch	hirsch	PROPN
ajst-10978	117	14	f.	f.	PROPN
ajst-10978	117	15	rationale	rationale	PROPN
ajst-10978	117	16	for	for	ADP
ajst-10978	117	17	targeting	target	VERB
ajst-10978	117	18	the	the	DET
ajst-10978	117	19	immune	immune	ADJ
ajst-10978	117	20	system	system	NOUN
ajst-10978	117	21	through	through	ADP
ajst-10978	117	22	checkpoint	checkpoint	NOUN
ajst-10978	117	23	molecule	molecule	NOUN
ajst-10978	117	24	blockade	blockade	NOUN
ajst-10978	117	25	in	in	ADP
ajst-10978	117	26	the	the	DET
ajst-10978	117	27	treatment	treatment	NOUN
ajst-10978	117	28	of	of	ADP
ajst-10978	117	29	non	non	ADJ
ajst-10978	117	30	-	-	ADJ
ajst-10978	117	31	small	small	ADJ
ajst-10978	117	32	-	-	PUNCT
ajst-10978	117	33	cell	cell	NOUN
ajst-10978	117	34	lung	lung	NOUN
ajst-10978	117	35	cancer	cancer	NOUN
ajst-10978	117	36	.	.	PUNCT
ajst-10978	118	1	annals	annal	NOUN
ajst-10978	118	2	of	of	ADP
ajst-10978	118	3	oncology	oncology	NOUN
ajst-10978	118	4	.	.	PUNCT
ajst-10978	119	1	2013	2013	NUM
ajst-10978	119	2	;	;	PUNCT
ajst-10978	119	3	24:1170	24:1170	NOUN
ajst-10978	119	4	-	-	SYM
ajst-10978	119	5	1179	1179	NUM
ajst-10978	119	6	.	.	PUNCT
ajst-10978	120	1	[	[	X
ajst-10978	120	2	11	11	NUM
ajst-10978	120	3	]	]	X
ajst-10978	120	4	hartkopf	hartkopf	ADJ
ajst-10978	120	5	ad	ad	NOUN
ajst-10978	120	6	,	,	PUNCT
ajst-10978	120	7	taran	taran	PROPN
ajst-10978	120	8	fa	fa	PROPN
ajst-10978	120	9	,	,	PUNCT
ajst-10978	120	10	wallwiener	wallwiener	NOUN
ajst-10978	120	11	m	m	PROPN
ajst-10978	120	12	,	,	PUNCT
ajst-10978	120	13	walter	walter	PROPN
ajst-10978	120	14	cb	cb	PROPN
ajst-10978	120	15	,	,	PUNCT
ajst-10978	120	16	kramer	kramer	PROPN
ajst-10978	120	17	b	b	PROPN
ajst-10978	120	18	,	,	PUNCT
ajst-10978	120	19	grischke	grischke	VERB
ajst-10978	120	20	em	em	PRON
ajst-10978	120	21	,	,	PUNCT
ajst-10978	120	22	et	et	PROPN
ajst-10978	120	23	al	al	PROPN
ajst-10978	120	24	.	.	PROPN
ajst-10978	120	25	pd-1	pd-1	ADP
ajst-10978	120	26	and	and	CCONJ
ajst-10978	120	27	pd	pd	PROPN
ajst-10978	120	28	-	-	PROPN
ajst-10978	120	29	l1	l1	PROPN
ajst-10978	120	30	immune	immune	ADJ
ajst-10978	120	31	checkpoint	checkpoint	NOUN
ajst-10978	120	32	blockade	blockade	NOUN
ajst-10978	120	33	to	to	PART
ajst-10978	120	34	treat	treat	VERB
ajst-10978	120	35	breast	breast	NOUN
ajst-10978	120	36	cancer	cancer	NOUN
ajst-10978	120	37	.	.	PUNCT
ajst-10978	121	1	breast	breast	NOUN
ajst-10978	121	2	care	care	NOUN
ajst-10978	121	3	.	.	PUNCT
ajst-10978	122	1	2016	2016	NUM
ajst-10978	122	2	;	;	PUNCT
ajst-10978	122	3	11:385390	11:385390	NUM
ajst-10978	122	4	.	.	PUNCT
ajst-10978	123	1	[	[	X
ajst-10978	123	2	12	12	NUM
ajst-10978	123	3	]	]	X
ajst-10978	123	4	gao	gao	PROPN
ajst-10978	123	5	mz	mz	PROPN
ajst-10978	123	6	,	,	PUNCT
ajst-10978	123	7	wang	wang	PROPN
ajst-10978	123	8	t	t	PROPN
ajst-10978	123	9	,	,	PUNCT
ajst-10978	123	10	ji	ji	PROPN
ajst-10978	123	11	lt	lt	PROPN
ajst-10978	123	12	,	,	PUNCT
ajst-10978	123	13	bai	bai	PROPN
ajst-10978	123	14	sp	sp	PROPN
ajst-10978	123	15	,	,	PUNCT
ajst-10978	123	16	tian	tian	PROPN
ajst-10978	123	17	ln	ln	ADJ
ajst-10978	123	18	,	,	PUNCT
ajst-10978	123	19	song	song	PROPN
ajst-10978	123	20	hj	hj	PROPN
ajst-10978	123	21	.	.	PROPN
ajst-10978	123	22	therapy	therapy	NOUN
ajst-10978	123	23	with	with	ADP
ajst-10978	123	24	carboplatin	carboplatin	NOUN
ajst-10978	123	25	and	and	CCONJ
ajst-10978	123	26	anti	anti	ADJ
ajst-10978	123	27	-	-	ADJ
ajst-10978	123	28	pd-1	pd-1	ADJ
ajst-10978	123	29	antibodies	antibody	NOUN
ajst-10978	123	30	before	before	ADP
ajst-10978	123	31	surgery	surgery	NOUN
ajst-10978	123	32	demonstrates	demonstrate	VERB
ajst-10978	123	33	sustainable	sustainable	ADJ
ajst-10978	123	34	anti	anti	ADJ
ajst-10978	123	35	-	-	ADJ
ajst-10978	123	36	tumor	tumor	ADJ
ajst-10978	123	37	effects	effect	NOUN
ajst-10978	123	38	for	for	ADP
ajst-10978	123	39	secondary	secondary	ADJ
ajst-10978	123	40	cancers	cancer	NOUN
ajst-10978	123	41	in	in	ADP
ajst-10978	123	42	mice	mouse	NOUN
ajst-10978	123	43	with	with	ADP
ajst-10978	123	44	triple	triple	ADJ
ajst-10978	123	45	-	-	PUNCT
ajst-10978	123	46	negative	negative	ADJ
ajst-10978	123	47	breast	breast	NOUN
ajst-10978	123	48	cancer	cancer	NOUN
ajst-10978	123	49	.	.	PUNCT
ajst-10978	124	1	frontiers	frontier	NOUN
ajst-10978	124	2	in	in	ADP
ajst-10978	124	3	immunology	immunology	NOUN
ajst-10978	124	4	.	.	PUNCT
ajst-10978	125	1	2020	2020	NUM
ajst-10978	125	2	;	;	PUNCT
ajst-10978	125	3	11	11	NUM
ajst-10978	125	4	.	.	PUNCT
ajst-10978	126	1	[	[	X
ajst-10978	126	2	13	13	NUM
ajst-10978	126	3	]	]	X
ajst-10978	126	4	zhao	zhao	PROPN
ajst-10978	126	5	t	t	PROPN
ajst-10978	126	6	,	,	PUNCT
ajst-10978	126	7	li	li	PROPN
ajst-10978	126	8	y	y	PROPN
ajst-10978	126	9	,	,	PUNCT
ajst-10978	126	10	zhang	zhang	PROPN
ajst-10978	126	11	j	j	PROPN
ajst-10978	126	12	,	,	PUNCT
ajst-10978	126	13	zhang	zhang	PROPN
ajst-10978	126	14	b.	b.	PROPN
ajst-10978	126	15	pd	pd	PROPN
ajst-10978	126	16	-	-	PROPN
ajst-10978	126	17	l1	l1	PROPN
ajst-10978	126	18	expression	expression	NOUN
ajst-10978	126	19	increased	increase	VERB
ajst-10978	126	20	by	by	ADP
ajst-10978	126	21	ifn	ifn	PROPN
ajst-10978	126	22	-	-	PUNCT
ajst-10978	126	23	gamma	gamma	NOUN
ajst-10978	126	24	via	via	ADP
ajst-10978	126	25	jak2	jak2	PROPN
ajst-10978	126	26	-	-	PUNCT
ajst-10978	126	27	stat1	stat1	NOUN
ajst-10978	126	28	signaling	signaling	NOUN
ajst-10978	126	29	and	and	CCONJ
ajst-10978	126	30	predicts	predict	VERB
ajst-10978	126	31	a	a	DET
ajst-10978	126	32	poor	poor	ADJ
ajst-10978	126	33	survival	survival	NOUN
ajst-10978	126	34	in	in	ADP
ajst-10978	126	35	colorectal	colorectal	ADJ
ajst-10978	126	36	cancer	cancer	NOUN
ajst-10978	126	37	.	.	PUNCT
ajst-10978	127	1	oncol	oncol	ADJ
ajst-10978	127	2	lett	lett	PROPN
ajst-10978	127	3	.	.	PUNCT
ajst-10978	128	1	2020	2020	NUM
ajst-10978	128	2	;	;	PUNCT
ajst-10978	128	3	20:1127	20:1127	X
ajst-10978	128	4	-	-	SYM
ajst-10978	128	5	1134	1134	NUM
ajst-10978	128	6	.	.	PUNCT
ajst-10978	129	1	[	[	X
ajst-10978	129	2	14	14	NUM
ajst-10978	129	3	]	]	X
ajst-10978	129	4	nakayama	nakayama	PROPN
ajst-10978	129	5	y	y	PROPN
ajst-10978	129	6	,	,	PUNCT
ajst-10978	129	7	mimura	mimura	PROPN
ajst-10978	129	8	k	k	PROPN
ajst-10978	129	9	,	,	PUNCT
ajst-10978	129	10	tamaki	tamaki	PROPN
ajst-10978	129	11	t	t	PROPN
ajst-10978	129	12	,	,	PUNCT
ajst-10978	129	13	shiraishi	shiraishi	PROPN
ajst-10978	129	14	k	k	PROPN
ajst-10978	129	15	,	,	PUNCT
ajst-10978	129	16	kua	kua	PROPN
ajst-10978	129	17	lf	lf	PROPN
ajst-10978	129	18	,	,	PUNCT
ajst-10978	129	19	koh	koh	PROPN
ajst-10978	129	20	v	v	PROPN
ajst-10978	129	21	,	,	PUNCT
ajst-10978	129	22	et	et	PROPN
ajst-10978	129	23	al	al	PROPN
ajst-10978	129	24	.	.	PROPN
ajst-10978	129	25	phospho	phospho	ADJ
ajst-10978	129	26	-	-	PUNCT
ajst-10978	129	27	stat1	stat1	NOUN
ajst-10978	129	28	expression	expression	NOUN
ajst-10978	129	29	as	as	ADP
ajst-10978	129	30	a	a	DET
ajst-10978	129	31	potential	potential	ADJ
ajst-10978	129	32	biomarker	biomarker	NOUN
ajst-10978	129	33	for	for	ADP
ajst-10978	129	34	anti	anti	ADJ
ajst-10978	129	35	-	-	ADJ
ajst-10978	129	36	pd-1	pd-1	ADJ
ajst-10978	129	37	/	/	SYM
ajst-10978	129	38	anti	anti	ADJ
ajst-10978	129	39	-	-	ADJ
ajst-10978	129	40	pd	pd	ADJ
ajst-10978	129	41	-	-	PUNCT
ajst-10978	129	42	l1	l1	PROPN
ajst-10978	129	43	immunotherapy	immunotherapy	NOUN
ajst-10978	129	44	for	for	ADP
ajst-10978	129	45	breast	breast	NOUN
ajst-10978	129	46	cancer	cancer	NOUN
ajst-10978	129	47	.	.	PUNCT
ajst-10978	130	1	international	international	ADJ
ajst-10978	130	2	journal	journal	PROPN
ajst-10978	130	3	of	of	ADP
ajst-10978	130	4	oncology	oncology	NOUN
ajst-10978	130	5	.	.	PUNCT
ajst-10978	131	1	2019	2019	NUM
ajst-10978	131	2	;	;	PUNCT
ajst-10978	131	3	54:2030	54:2030	NOUN
ajst-10978	131	4	-	-	NOUN
ajst-10978	131	5	2038	2038	NUM
ajst-10978	131	6	.	.	PUNCT
ajst-10978	132	1	[	[	X
ajst-10978	132	2	15	15	NUM
ajst-10978	132	3	]	]	X
ajst-10978	132	4	owen	owen	PROPN
ajst-10978	132	5	kl	kl	PROPN
ajst-10978	132	6	,	,	PUNCT
ajst-10978	132	7	brockwell	brockwell	PROPN
ajst-10978	132	8	nk	nk	PROPN
ajst-10978	132	9	,	,	PUNCT
ajst-10978	132	10	parker	parker	PROPN
ajst-10978	132	11	bs	bs	PROPN
ajst-10978	132	12	.	.	PUNCT
ajst-10978	132	13	jak	jak	PROPN
ajst-10978	132	14	-	-	PUNCT
ajst-10978	132	15	stat	stat	PROPN
ajst-10978	132	16	signaling	signal	VERB
ajst-10978	132	17	:	:	PUNCT
ajst-10978	132	18	a	a	DET
ajst-10978	132	19	double	double	ADJ
ajst-10978	132	20	-	-	PUNCT
ajst-10978	132	21	edged	edge	VERB
ajst-10978	132	22	sword	sword	NOUN
ajst-10978	132	23	of	of	ADP
ajst-10978	132	24	immune	immune	ADJ
ajst-10978	132	25	regulation	regulation	NOUN
ajst-10978	132	26	and	and	CCONJ
ajst-10978	132	27	cancer	cancer	NOUN
ajst-10978	132	28	progression	progression	NOUN
ajst-10978	132	29	.	.	PUNCT
ajst-10978	133	1	cancers	cancer	NOUN
ajst-10978	133	2	.	.	PUNCT
ajst-10978	134	1	2019	2019	NUM
ajst-10978	134	2	;	;	PUNCT
ajst-10978	134	3	11	11	NUM
ajst-10978	134	4	.	.	PUNCT
ajst-10978	135	1	[	[	X
ajst-10978	135	2	16	16	NUM
ajst-10978	135	3	]	]	X
ajst-10978	135	4	sung	sung	PROPN
ajst-10978	135	5	h	h	NOUN
ajst-10978	135	6	,	,	PUNCT
ajst-10978	135	7	ferlay	ferlay	PROPN
ajst-10978	135	8	j	j	PROPN
ajst-10978	135	9	,	,	PUNCT
ajst-10978	135	10	siegel	siegel	PROPN
ajst-10978	135	11	r	r	PROPN
ajst-10978	135	12	l	l	PROPN
ajst-10978	135	13	,	,	PUNCT
ajst-10978	135	14	et	et	PROPN
ajst-10978	135	15	al	al	PROPN
ajst-10978	135	16	.	.	PUNCT
ajst-10978	136	1	global	global	ADJ
ajst-10978	136	2	cancer	cancer	NOUN
ajst-10978	136	3	statistics	statistic	NOUN
ajst-10978	136	4	2020	2020	NUM
ajst-10978	136	5	:	:	PUNCT
ajst-10978	136	6	globocan	globocan	PROPN
ajst-10978	136	7	estimates	estimate	NOUN
ajst-10978	136	8	of	of	ADP
ajst-10978	136	9	incidence	incidence	NOUN
ajst-10978	136	10	and	and	CCONJ
ajst-10978	136	11	mortality	mortality	NOUN
ajst-10978	136	12	worldwide	worldwide	ADV
ajst-10978	136	13	for	for	ADP
ajst-10978	136	14	36	36	NUM
ajst-10978	136	15	cancers	cancer	NOUN
ajst-10978	136	16	in	in	ADP
ajst-10978	136	17	185	185	NUM
ajst-10978	136	18	countries[j	countries[j	NOUN
ajst-10978	136	19	]	]	X
ajst-10978	136	20	.	.	PUNCT
ajst-10978	137	1	ca	can	AUX
ajst-10978	137	2	cancer	cancer	PROPN
ajst-10978	137	3	j	j	PROPN
ajst-10978	137	4	clin	clin	PROPN
ajst-10978	137	5	,	,	PUNCT
ajst-10978	137	6	2021	2021	NUM
ajst-10978	137	7	,	,	PUNCT
ajst-10978	137	8	71(3	71(3	NUM
ajst-10978	137	9	):	):	PUNCT
ajst-10978	137	10	209	209	NUM
ajst-10978	137	11	-	-	SYM
ajst-10978	137	12	249	249	NUM
ajst-10978	137	13	.	.	PUNCT
ajst-10978	138	1	[	[	X
ajst-10978	138	2	17	17	NUM
ajst-10978	138	3	]	]	PUNCT
ajst-10978	138	4	sasidharan	sasidharan	PROPN
ajst-10978	138	5	nair	nair	PROPN
ajst-10978	138	6	v	v	PROPN
ajst-10978	138	7	,	,	PUNCT
ajst-10978	138	8	toor	toor	PROPN
ajst-10978	138	9	s	s	PART
ajst-10978	138	10	m	m	PROPN
ajst-10978	138	11	,	,	PUNCT
ajst-10978	138	12	ali	ali	PROPN
ajst-10978	138	13	b	b	PROPN
ajst-10978	138	14	r	r	PROPN
ajst-10978	138	15	,	,	PUNCT
ajst-10978	138	16	et	et	PROPN
ajst-10978	138	17	al	al	PROPN
ajst-10978	138	18	.	.	PUNCT
ajst-10978	139	1	dual	dual	ADJ
ajst-10978	139	2	inhibition	inhibition	NOUN
ajst-10978	139	3	of	of	ADP
ajst-10978	139	4	stat1	stat1	NOUN
ajst-10978	139	5	and	and	CCONJ
ajst-10978	139	6	stat3	stat3	NOUN
ajst-10978	139	7	activation	activation	NOUN
ajst-10978	139	8	downregulates	downregulate	VERB
ajst-10978	139	9	expression	expression	NOUN
ajst-10978	139	10	of	of	ADP
ajst-10978	139	11	pd	pd	PROPN
ajst-10978	139	12	-	-	PROPN
ajst-10978	139	13	l1	l1	PROPN
ajst-10978	139	14	in	in	ADP
ajst-10978	139	15	human	human	ADJ
ajst-10978	139	16	breast	breast	NOUN
ajst-10978	139	17	cancer	cancer	NOUN
ajst-10978	139	18	cells[j	cells[j	PROPN
ajst-10978	139	19	]	]	PUNCT
ajst-10978	139	20	.	.	PUNCT
ajst-10978	140	1	expert	expert	NOUN
ajst-10978	140	2	opin	opin	NOUN
ajst-10978	140	3	ther	ther	NOUN
ajst-10978	140	4	targets	target	NOUN
ajst-10978	140	5	,	,	PUNCT
ajst-10978	140	6	2018	2018	NUM
ajst-10978	140	7	,	,	PUNCT
ajst-10978	140	8	22(6	22(6	NUM
ajst-10978	140	9	):	):	PUNCT
ajst-10978	140	10	547	547	NUM
ajst-10978	140	11	-	-	SYM
ajst-10978	140	12	557	557	NUM
ajst-10978	140	13	.	.	PUNCT
ajst-10978	141	1	[	[	X
ajst-10978	141	2	18	18	NUM
ajst-10978	141	3	]	]	X
ajst-10978	141	4	wong	wong	PROPN
ajst-10978	141	5	g	g	PROPN
ajst-10978	141	6	l	l	PROPN
ajst-10978	141	7	,	,	PUNCT
ajst-10978	141	8	manore	manore	PROPN
ajst-10978	141	9	s	s	NOUN
ajst-10978	141	10	g	g	NOUN
ajst-10978	141	11	,	,	PUNCT
ajst-10978	141	12	doheny	doheny	PROPN
ajst-10978	141	13	d	d	PROPN
ajst-10978	141	14	l	l	PROPN
ajst-10978	141	15	,	,	PUNCT
ajst-10978	141	16	et	et	PROPN
ajst-10978	141	17	al	al	PROPN
ajst-10978	141	18	.	.	PROPN
ajst-10978	142	1	stat	stat	PROPN
ajst-10978	142	2	family	family	PROPN
ajst-10978	142	3	of	of	ADP
ajst-10978	142	4	transcription	transcription	NOUN
ajst-10978	142	5	factors	factor	NOUN
ajst-10978	142	6	in	in	ADP
ajst-10978	142	7	breast	breast	NOUN
ajst-10978	142	8	cancer	cancer	NOUN
ajst-10978	142	9	:	:	PUNCT
ajst-10978	142	10	pathogenesis	pathogenesis	NOUN
ajst-10978	142	11	and	and	CCONJ
ajst-10978	142	12	therapeutic	therapeutic	ADJ
ajst-10978	142	13	opportunities	opportunity	NOUN
ajst-10978	142	14	and	and	CCONJ
ajst-10978	142	15	challenges[j	challenges[j	NOUN
ajst-10978	142	16	]	]	PUNCT
ajst-10978	142	17	.	.	PUNCT
ajst-10978	143	1	semin	semin	PROPN
ajst-10978	143	2	cancer	cancer	PROPN
ajst-10978	143	3	biol	biol	PROPN
ajst-10978	143	4	,	,	PUNCT
ajst-10978	143	5	2022	2022	NUM
ajst-10978	143	6	,	,	PUNCT
ajst-10978	143	7	86(pt	86(pt	NUM
ajst-10978	143	8	3	3	NUM
ajst-10978	143	9	):	):	PUNCT
ajst-10978	143	10	84	84	NUM
ajst-10978	143	11	-	-	SYM
ajst-10978	143	12	106	106	NUM
ajst-10978	143	13	.	.	PUNCT
ajst-10978	144	1	[	[	X
ajst-10978	144	2	19	19	NUM
ajst-10978	144	3	]	]	X
ajst-10978	144	4	nakayama	nakayama	PROPN
ajst-10978	144	5	y	y	PROPN
ajst-10978	144	6	,	,	PUNCT
ajst-10978	144	7	mimura	mimura	PROPN
ajst-10978	144	8	k	k	PROPN
ajst-10978	144	9	,	,	PUNCT
ajst-10978	144	10	tamaki	tamaki	PROPN
ajst-10978	144	11	t	t	PROPN
ajst-10978	144	12	,	,	PUNCT
ajst-10978	144	13	et	et	PROPN
ajst-10978	144	14	al	al	PROPN
ajst-10978	144	15	.	.	PROPN
ajst-10978	144	16	phospho‑stat1	phospho‑stat1	NOUN
ajst-10978	144	17	expression	expression	NOUN
ajst-10978	144	18	as	as	ADP
ajst-10978	144	19	a	a	DET
ajst-10978	144	20	potential	potential	ADJ
ajst-10978	144	21	biomarker	biomarker	NOUN
ajst-10978	144	22	for	for	ADP
ajst-10978	144	23	anti‑pd‑1	anti‑pd‑1	NUM
ajst-10978	144	24	/	/	SYM
ajst-10978	144	25	anti‑pd‑l1	anti‑pd‑l1	NOUN
ajst-10978	144	26	immunotherapy	immunotherapy	NOUN
ajst-10978	144	27	for	for	ADP
ajst-10978	144	28	breast	breast	NOUN
ajst-10978	144	29	cancer[j	cancer[j	NOUN
ajst-10978	144	30	]	]	PUNCT
ajst-10978	144	31	.	.	PUNCT
ajst-10978	145	1	int	int	PROPN
ajst-10978	145	2	j	j	PROPN
ajst-10978	145	3	oncol	oncol	ADJ
ajst-10978	145	4	,	,	PUNCT
ajst-10978	145	5	2019	2019	NUM
ajst-10978	145	6	,	,	PUNCT
ajst-10978	145	7	54(6	54(6	NUM
ajst-10978	145	8	):	):	PUNCT
ajst-10978	145	9	2030	2030	NUM
ajst-10978	145	10	-	-	SYM
ajst-10978	145	11	2038	2038	NUM
ajst-10978	145	12	.	.	PUNCT
ajst-10978	146	1	[	[	X
ajst-10978	146	2	20	20	NUM
ajst-10978	146	3	]	]	X
ajst-10978	146	4	alkhayyal	alkhayyal	NOUN
ajst-10978	146	5	n	n	CCONJ
ajst-10978	146	6	,	,	PUNCT
ajst-10978	146	7	elemam	elemam	PROPN
ajst-10978	146	8	n	n	PROPN
ajst-10978	146	9	m	m	PROPN
ajst-10978	146	10	,	,	PUNCT
ajst-10978	146	11	hussein	hussein	PROPN
ajst-10978	146	12	a	a	PRON
ajst-10978	146	13	,	,	PUNCT
ajst-10978	146	14	et	et	PROPN
ajst-10978	146	15	al	al	PROPN
ajst-10978	146	16	.	.	PUNCT
ajst-10978	146	17	expression	expression	NOUN
ajst-10978	146	18	of	of	ADP
ajst-10978	146	19	immune	immune	ADJ
ajst-10978	146	20	checkpoints	checkpoint	NOUN
ajst-10978	146	21	(	(	PUNCT
ajst-10978	146	22	pd	pd	NOUN
ajst-10978	146	23	-	-	PROPN
ajst-10978	146	24	l1	l1	PROPN
ajst-10978	146	25	and	and	CCONJ
ajst-10978	146	26	ido	ido	PROPN
ajst-10978	146	27	)	)	PUNCT
ajst-10978	146	28	and	and	CCONJ
ajst-10978	146	29	tumour	tumour	NOUN
ajst-10978	146	30	-	-	PUNCT
ajst-10978	146	31	infiltrating	infiltrating	ADJ
ajst-10978	146	32	lymphocytes	lymphocyte	NOUN
ajst-10978	146	33	in	in	ADP
ajst-10978	146	34	breast	breast	NOUN
ajst-10978	146	35	cancer[j	cancer[j	NOUN
ajst-10978	146	36	]	]	PUNCT
ajst-10978	146	37	.	.	PUNCT
ajst-10978	147	1	heliyon	heliyon	NOUN
ajst-10978	147	2	,	,	PUNCT
ajst-10978	147	3	2022	2022	NUM
ajst-10978	147	4	,	,	PUNCT
ajst-10978	147	5	8(9	8(9	NUM
ajst-10978	147	6	):	):	PUNCT
ajst-10978	147	7	e10482	e10482	PROPN
ajst-10978	147	8	.	.	PUNCT
ajst-10978	148	1	[	[	X
ajst-10978	148	2	21	21	NUM
ajst-10978	148	3	]	]	X
ajst-10978	148	4	dill	dill	NOUN
ajst-10978	148	5	e	e	X
ajst-10978	148	6	a	a	X
ajst-10978	148	7	,	,	PUNCT
ajst-10978	148	8	dillon	dillon	PROPN
ajst-10978	148	9	p	p	PROPN
ajst-10978	148	10	m	m	PROPN
ajst-10978	148	11	,	,	PUNCT
ajst-10978	148	12	bullock	bullock	PROPN
ajst-10978	148	13	t	t	PROPN
ajst-10978	148	14	n	n	CCONJ
ajst-10978	148	15	,	,	PUNCT
ajst-10978	148	16	et	et	PROPN
ajst-10978	148	17	al	al	PROPN
ajst-10978	148	18	.	.	PUNCT
ajst-10978	148	19	ido	ido	PROPN
ajst-10978	148	20	expression	expression	NOUN
ajst-10978	148	21	in	in	ADP
ajst-10978	148	22	breast	breast	NOUN
ajst-10978	148	23	cancer	cancer	NOUN
ajst-10978	148	24	:	:	PUNCT
ajst-10978	148	25	an	an	DET
ajst-10978	148	26	assessment	assessment	NOUN
ajst-10978	148	27	of	of	ADP
ajst-10978	148	28	281	281	NUM
ajst-10978	148	29	primary	primary	ADJ
ajst-10978	148	30	and	and	CCONJ
ajst-10978	148	31	metastatic	metastatic	ADJ
ajst-10978	148	32	cases	case	NOUN
ajst-10978	148	33	with	with	ADP
ajst-10978	148	34	comparison	comparison	NOUN
ajst-10978	148	35	to	to	ADP
ajst-10978	148	36	pd	pd	NOUN
ajst-10978	148	37	-	-	PUNCT
ajst-10978	148	38	l1[j	l1[j	PROPN
ajst-10978	148	39	]	]	PUNCT
ajst-10978	148	40	.	.	PUNCT
ajst-10978	149	1	mod	mod	PROPN
ajst-10978	149	2	pathol	pathol	PROPN
ajst-10978	149	3	,	,	PUNCT
ajst-10978	149	4	2018	2018	NUM
ajst-10978	149	5	,	,	PUNCT
ajst-10978	149	6	31(10	31(10	NUM
ajst-10978	149	7	):	):	PUNCT
ajst-10978	149	8	1513	1513	NUM
ajst-10978	149	9	-	-	SYM
ajst-10978	149	10	1522	1522	NUM
ajst-10978	149	11	.	.	PUNCT
ajst-10978	150	1	[	[	X
ajst-10978	150	2	22	22	NUM
ajst-10978	150	3	]	]	X
ajst-10978	150	4	kern	kern	PROPN
ajst-10978	150	5	r	r	PROPN
ajst-10978	150	6	,	,	PUNCT
ajst-10978	150	7	panis	panis	PROPN
ajst-10978	150	8	c.	c.	PROPN
ajst-10978	150	9	ctla-4	ctla-4	NOUN
ajst-10978	150	10	expression	expression	NOUN
ajst-10978	150	11	and	and	CCONJ
ajst-10978	150	12	its	its	PRON
ajst-10978	150	13	clinical	clinical	ADJ
ajst-10978	150	14	significance	significance	NOUN
ajst-10978	150	15	in	in	ADP
ajst-10978	150	16	breast	breast	NOUN
ajst-10978	150	17	cancer[j	cancer[j	NOUN
ajst-10978	150	18	]	]	PUNCT
ajst-10978	150	19	.	.	PUNCT
ajst-10978	151	1	arch	arch	ADJ
ajst-10978	151	2	immunol	immunol	NOUN
ajst-10978	151	3	ther	ther	PROPN
ajst-10978	151	4	exp	exp	PROPN
ajst-10978	151	5	(	(	PUNCT
ajst-10978	151	6	warsz	warsz	PROPN
ajst-10978	151	7	)	)	PUNCT
ajst-10978	151	8	,	,	PUNCT
ajst-10978	151	9	2021	2021	NUM
ajst-10978	151	10	,	,	PUNCT
ajst-10978	151	11	69(1	69(1	NUM
ajst-10978	151	12	):	):	PUNCT
ajst-10978	151	13	16	16	NUM
ajst-10978	151	14	.	.	PUNCT
ajst-10978	152	1	[	[	X
ajst-10978	152	2	23	23	NUM
ajst-10978	152	3	]	]	X
ajst-10978	152	4	fang	fang	PROPN
ajst-10978	152	5	j	j	PROPN
ajst-10978	152	6	,	,	PUNCT
ajst-10978	152	7	chen	chen	PROPN
ajst-10978	152	8	f	f	PROPN
ajst-10978	152	9	,	,	PUNCT
ajst-10978	152	10	liu	liu	PROPN
ajst-10978	152	11	d	d	PROPN
ajst-10978	152	12	,	,	PUNCT
ajst-10978	152	13	et	et	PROPN
ajst-10978	152	14	al	al	PROPN
ajst-10978	152	15	.	.	PROPN
ajst-10978	153	1	prognostic	prognostic	ADJ
ajst-10978	153	2	value	value	NOUN
ajst-10978	153	3	of	of	ADP
ajst-10978	153	4	immune	immune	ADJ
ajst-10978	153	5	checkpoint	checkpoint	NOUN
ajst-10978	153	6	molecules	molecule	NOUN
ajst-10978	153	7	in	in	ADP
ajst-10978	153	8	breast	breast	NOUN
ajst-10978	153	9	cancer[j	cancer[j	NOUN
ajst-10978	153	10	]	]	PUNCT
ajst-10978	153	11	.	.	PUNCT
ajst-10978	154	1	biosci	biosci	PROPN
ajst-10978	154	2	rep	rep	PROPN
ajst-10978	154	3	,	,	PUNCT
ajst-10978	154	4	2020	2020	NUM
ajst-10978	154	5	,	,	PUNCT
ajst-10978	154	6	40(7	40(7	NOUN
ajst-10978	154	7	)	)	PUNCT
ajst-10978	154	8	.	.	PUNCT
ajst-10978	155	1	[	[	X
ajst-10978	155	2	24	24	NUM
ajst-10978	155	3	]	]	X
ajst-10978	155	4	du	du	PROPN
ajst-10978	155	5	h	h	PROPN
ajst-10978	155	6	,	,	PUNCT
ajst-10978	155	7	yi	yi	PROPN
ajst-10978	155	8	z	z	PROPN
ajst-10978	155	9	,	,	PUNCT
ajst-10978	155	10	wang	wang	PROPN
ajst-10978	155	11	l	l	PROPN
ajst-10978	155	12	,	,	PUNCT
ajst-10978	155	13	et	et	PROPN
ajst-10978	155	14	al	al	PROPN
ajst-10978	155	15	.	.	PUNCT
ajst-10978	156	1	the	the	DET
ajst-10978	156	2	co	co	NOUN
ajst-10978	156	3	-	-	NOUN
ajst-10978	156	4	expression	expression	ADJ
ajst-10978	156	5	characteristics	characteristic	NOUN
ajst-10978	156	6	of	of	ADP
ajst-10978	156	7	lag3	lag3	PROPN
ajst-10978	156	8	and	and	CCONJ
ajst-10978	156	9	pd-1	pd-1	ADV
ajst-10978	156	10	on	on	ADP
ajst-10978	156	11	the	the	DET
ajst-10978	156	12	t	t	NOUN
ajst-10978	156	13	cells	cell	NOUN
ajst-10978	156	14	of	of	ADP
ajst-10978	156	15	patients	patient	NOUN
ajst-10978	156	16	with	with	ADP
ajst-10978	156	17	breast	breast	NOUN
ajst-10978	156	18	cancer	cancer	NOUN
ajst-10978	156	19	reveal	reveal	VERB
ajst-10978	156	20	a	a	DET
ajst-10978	156	21	new	new	ADJ
ajst-10978	156	22	therapeutic	therapeutic	ADJ
ajst-10978	156	23	strategy[j	strategy[j	NOUN
ajst-10978	156	24	]	]	X
ajst-10978	156	25	.	.	PUNCT
ajst-10978	157	1	int	int	PROPN
ajst-10978	157	2	immunopharmacol	immunopharmacol	PROPN
ajst-10978	157	3	,	,	PUNCT
ajst-10978	157	4	2020	2020	NUM
ajst-10978	157	5	,	,	PUNCT
ajst-10978	157	6	78	78	NUM
ajst-10978	157	7	:	:	SYM
ajst-10978	157	8	106113	106113	NUM
ajst-10978	157	9	.	.	PUNCT
ajst-10978	158	1	[	[	X
ajst-10978	158	2	25	25	NUM
ajst-10978	158	3	]	]	PUNCT
ajst-10978	158	4	pedraza	pedraza	PROPN
ajst-10978	158	5	v	v	PROPN
ajst-10978	158	6	,	,	PUNCT
ajst-10978	158	7	gomez	gomez	NOUN
ajst-10978	158	8	-	-	PUNCT
ajst-10978	158	9	capilla	capilla	PROPN
ajst-10978	158	10	ja	ja	PROPN
ajst-10978	158	11	,	,	PUNCT
ajst-10978	158	12	escaramis	escaramis	PROPN
ajst-10978	158	13	g	g	PROPN
ajst-10978	158	14	,	,	PUNCT
ajst-10978	158	15	gomez	gomez	PROPN
ajst-10978	158	16	c	c	PROPN
ajst-10978	158	17	,	,	PUNCT
ajst-10978	158	18	torne	torne	VERB
ajst-10978	158	19	p	p	PRON
ajst-10978	158	20	,	,	PUNCT
ajst-10978	158	21	rivera	rivera	PROPN
ajst-10978	158	22	jm	jm	PROPN
ajst-10978	158	23	,	,	PUNCT
ajst-10978	158	24	et	et	PROPN
ajst-10978	159	1	al	al	PROPN
ajst-10978	159	2	.	.	PUNCT
ajst-10978	159	3	gene	gene	NOUN
ajst-10978	159	4	expression	expression	NOUN
ajst-10978	159	5	signatures	signature	NOUN
ajst-10978	159	6	in	in	ADP
ajst-10978	159	7	breast	breast	NOUN
ajst-10978	159	8	cancer	cancer	NOUN
ajst-10978	159	9	distinguish	distinguish	VERB
ajst-10978	159	10	phenotype	phenotype	NOUN
ajst-10978	159	11	characteristics	characteristic	NOUN
ajst-10978	159	12	,	,	PUNCT
ajst-10978	159	13	histologic	histologic	ADJ
ajst-10978	159	14	subtypes	subtype	NOUN
ajst-10978	159	15	,	,	PUNCT
ajst-10978	159	16	and	and	CCONJ
ajst-10978	159	17	tumor	tumor	NOUN
ajst-10978	159	18	invasiveness	invasiveness	NOUN
ajst-10978	159	19	.	.	PUNCT
ajst-10978	160	1	cancer	cancer	NOUN
ajst-10978	160	2	.	.	PUNCT
ajst-10978	161	1	2010	2010	NUM
ajst-10978	161	2	;	;	PUNCT
ajst-10978	161	3	116:486	116:486	NUM
ajst-10978	161	4	-	-	PUNCT
ajst-10978	161	5	496	496	NUM
ajst-10978	161	6	.	.	PUNCT
ajst-10978	162	1	[	[	X
ajst-10978	162	2	26	26	NUM
ajst-10978	162	3	]	]	X
ajst-10978	162	4	livak	livak	PROPN
ajst-10978	162	5	kj	kj	PROPN
ajst-10978	162	6	,	,	PUNCT
ajst-10978	162	7	schmittgen	schmittgen	PROPN
ajst-10978	162	8	td	td	NOUN
ajst-10978	162	9	.	.	PUNCT
ajst-10978	162	10	analysis	analysis	NOUN
ajst-10978	162	11	of	of	ADP
ajst-10978	162	12	relative	relative	ADJ
ajst-10978	162	13	gene	gene	NOUN
ajst-10978	162	14	expression	expression	NOUN
ajst-10978	162	15	data	datum	NOUN
ajst-10978	162	16	using	use	VERB
ajst-10978	162	17	real	real	ADJ
ajst-10978	162	18	-	-	PUNCT
ajst-10978	162	19	time	time	NOUN
ajst-10978	162	20	quantitative	quantitative	ADJ
ajst-10978	162	21	pcr	pcr	NOUN
ajst-10978	162	22	and	and	CCONJ
ajst-10978	162	23	the	the	DET
ajst-10978	162	24	2(t)(-delta	2(t)(-delta	NUM
ajst-10978	162	25	delta	delta	NOUN
ajst-10978	162	26	c	c	NOUN
ajst-10978	162	27	)	)	PUNCT
ajst-10978	162	28	method	method	NOUN
ajst-10978	162	29	.	.	PUNCT
ajst-10978	163	1	methods	method	NOUN
ajst-10978	163	2	.	.	PUNCT
ajst-10978	164	1	2001	2001	NUM
ajst-10978	164	2	;	;	PUNCT
ajst-10978	164	3	25:402	25:402	NUM
ajst-10978	164	4	-	-	SYM
ajst-10978	164	5	408	408	NUM
ajst-10978	164	6	.	.	PUNCT
ajst-10978	165	1	[	[	X
ajst-10978	165	2	27	27	NUM
ajst-10978	165	3	]	]	SYM
ajst-10978	165	4	li	li	PROPN
ajst-10978	165	5	g	g	PROPN
ajst-10978	165	6	,	,	PUNCT
ajst-10978	165	7	zhang	zhang	PROPN
ajst-10978	165	8	z	z	PROPN
ajst-10978	165	9	,	,	PUNCT
ajst-10978	165	10	chen	chen	PROPN
ajst-10978	165	11	z	z	PROPN
ajst-10978	165	12	,	,	PUNCT
ajst-10978	165	13	liu	liu	PROPN
ajst-10978	165	14	b	b	PROPN
ajst-10978	165	15	,	,	PUNCT
ajst-10978	165	16	wu	wu	PROPN
ajst-10978	165	17	h.	h.	PROPN
ajst-10978	165	18	lncrna	lncrna	PROPN
ajst-10978	165	19	dleu2	dleu2	NOUN
ajst-10978	165	20	is	be	AUX
ajst-10978	165	21	activated	activate	VERB
ajst-10978	165	22	by	by	ADP
ajst-10978	165	23	stat1	stat1	NOUN
ajst-10978	165	24	and	and	CCONJ
ajst-10978	165	25	induces	induce	VERB
ajst-10978	165	26	gastric	gastric	ADJ
ajst-10978	165	27	cancer	cancer	NOUN
ajst-10978	165	28	development	development	NOUN
ajst-10978	165	29	via	via	ADP
ajst-10978	165	30	targeting	target	VERB
ajst-10978	165	31	mir-23b-3p	mir-23b-3p	PROPN
ajst-10978	165	32	/	/	SYM
ajst-10978	165	33	notch2	notch2	NOUN
ajst-10978	165	34	axis	axis	NOUN
ajst-10978	165	35	and	and	CCONJ
ajst-10978	165	36	notch	notch	ADJ
ajst-10978	165	37	signaling	signal	VERB
ajst-10978	165	38	pathway	pathway	NOUN
ajst-10978	165	39	.	.	PUNCT
ajst-10978	166	1	life	life	NOUN
ajst-10978	166	2	sci	sci	PROPN
ajst-10978	166	3	.	.	PROPN
ajst-10978	166	4	2021	2021	NUM
ajst-10978	166	5	;	;	PUNCT
ajst-10978	166	6	277:119419	277:119419	NUM
ajst-10978	166	7	.	.	PUNCT
ajst-10978	167	1	[	[	X
ajst-10978	167	2	28	28	NUM
ajst-10978	167	3	]	]	X
ajst-10978	167	4	li	li	PROPN
ajst-10978	167	5	x	x	PROPN
ajst-10978	167	6	,	,	PUNCT
ajst-10978	167	7	wang	wang	PROPN
ajst-10978	167	8	z	z	PROPN
ajst-10978	167	9	,	,	PUNCT
ajst-10978	167	10	zhang	zhang	PROPN
ajst-10978	167	11	sj	sj	PROPN
ajst-10978	167	12	,	,	PUNCT
ajst-10978	167	13	yao	yao	PROPN
ajst-10978	167	14	qh	qh	PROPN
ajst-10978	167	15	,	,	PUNCT
ajst-10978	167	16	chen	chen	PROPN
ajst-10978	167	17	w	w	PROPN
ajst-10978	167	18	,	,	PUNCT
ajst-10978	167	19	liu	liu	PROPN
ajst-10978	167	20	fy	fy	PROPN
ajst-10978	167	21	.	.	PROPN
ajst-10978	167	22	ruxolitinib	ruxolitinib	PROPN
ajst-10978	167	23	induces	induce	VERB
ajst-10978	167	24	apoptosis	apoptosis	NOUN
ajst-10978	167	25	of	of	ADP
ajst-10978	167	26	human	human	ADJ
ajst-10978	167	27	colorectal	colorectal	ADJ
ajst-10978	167	28	cancer	cancer	NOUN
ajst-10978	167	29	cells	cell	NOUN
ajst-10978	167	30	by	by	ADP
ajst-10978	167	31	downregulating	downregulate	VERB
ajst-10978	167	32	the	the	DET
ajst-10978	167	33	jak1/2	jak1/2	PROPN
ajst-10978	167	34	-	-	PUNCT
ajst-10978	167	35	stat1	stat1	NOUN
ajst-10978	167	36	-	-	PUNCT
ajst-10978	167	37	mcl-1	mcl-1	ADV
ajst-10978	167	38	axis	axis	NOUN
ajst-10978	167	39	.	.	PUNCT
ajst-10978	168	1	oncology	oncology	NOUN
ajst-10978	168	2	letters	letter	NOUN
ajst-10978	168	3	.	.	PUNCT
ajst-10978	169	1	2021	2021	NUM
ajst-10978	169	2	;	;	PUNCT
ajst-10978	169	3	21	21	NUM
ajst-10978	169	4	.	.	PUNCT
ajst-10978	170	1	[	[	X
ajst-10978	170	2	29	29	NUM
ajst-10978	170	3	]	]	X
ajst-10978	170	4	li	li	PROPN
ajst-10978	170	5	x	x	PROPN
ajst-10978	170	6	,	,	PUNCT
ajst-10978	170	7	wang	wang	PROPN
ajst-10978	170	8	fc	fc	PROPN
ajst-10978	170	9	,	,	PUNCT
ajst-10978	170	10	xu	xu	PROPN
ajst-10978	170	11	xl	xl	PROPN
ajst-10978	170	12	,	,	PUNCT
ajst-10978	170	13	zhang	zhang	PROPN
ajst-10978	170	14	jg	jg	PROPN
ajst-10978	170	15	,	,	PUNCT
ajst-10978	170	16	xu	xu	PROPN
ajst-10978	170	17	gx	gx	PROPN
ajst-10978	170	18	.	.	PUNCT
ajst-10978	171	1	the	the	DET
ajst-10978	171	2	dual	dual	ADJ
ajst-10978	171	3	role	role	NOUN
ajst-10978	171	4	of	of	ADP
ajst-10978	171	5	stat1	stat1	NOUN
ajst-10978	171	6	in	in	ADP
ajst-10978	171	7	ovarian	ovarian	ADJ
ajst-10978	171	8	cancer	cancer	NOUN
ajst-10978	171	9	:	:	PUNCT
ajst-10978	171	10	insight	insight	NOUN
ajst-10978	171	11	into	into	ADP
ajst-10978	171	12	molecular	molecular	ADJ
ajst-10978	171	13	mechanisms	mechanism	NOUN
ajst-10978	171	14	and	and	CCONJ
ajst-10978	171	15	application	application	NOUN
ajst-10978	171	16	potentials	potential	NOUN
ajst-10978	171	17	.	.	PUNCT
ajst-10978	172	1	frontiers	frontier	NOUN
ajst-10978	172	2	in	in	ADP
ajst-10978	172	3	cell	cell	NOUN
ajst-10978	172	4	and	and	CCONJ
ajst-10978	172	5	developmental	developmental	ADJ
ajst-10978	172	6	biology	biology	NOUN
ajst-10978	172	7	.	.	PUNCT
ajst-10978	172	8	2021	2021	NUM
ajst-10978	172	9	;	;	PUNCT
ajst-10978	172	10	9	9	NUM
ajst-10978	172	11	.	.	PUNCT
ajst-10978	173	1	[	[	X
ajst-10978	173	2	30	30	NUM
ajst-10978	173	3	]	]	X
ajst-10978	173	4	totten	totten	PROPN
ajst-10978	173	5	sp	sp	PROPN
ajst-10978	173	6	,	,	PUNCT
ajst-10978	173	7	i	i	PROPN
ajst-10978	173	8	m	m	PROPN
ajst-10978	173	9	yk	yk	PROPN
ajst-10978	173	10	,	,	PUNCT
ajst-10978	173	11	cepeda	cepeda	PROPN
ajst-10978	173	12	canedo	canedo	PROPN
ajst-10978	173	13	e	e	PROPN
ajst-10978	173	14	,	,	PUNCT
ajst-10978	173	15	najyb	najyb	ADJ
ajst-10978	173	16	o	o	NOUN
ajst-10978	173	17	,	,	PUNCT
ajst-10978	173	18	nguyen	nguyen	PROPN
ajst-10978	173	19	a	a	X
ajst-10978	173	20	,	,	PUNCT
ajst-10978	173	21	hebert	hebert	NOUN
ajst-10978	173	22	s	s	PROPN
ajst-10978	173	23	,	,	PUNCT
ajst-10978	173	24	et	et	PROPN
ajst-10978	173	25	al	al	PROPN
ajst-10978	173	26	.	.	PROPN
ajst-10978	173	27	stat1	stat1	PROPN
ajst-10978	173	28	potentiates	potentiate	NOUN
ajst-10978	173	29	oxidative	oxidative	ADJ
ajst-10978	173	30	stress	stress	NOUN
ajst-10978	173	31	revealing	reveal	VERB
ajst-10978	173	32	a	a	DET
ajst-10978	173	33	targetable	targetable	ADJ
ajst-10978	173	34	vulnerability	vulnerability	NOUN
ajst-10978	173	35	that	that	PRON
ajst-10978	173	36	increases	increase	VERB
ajst-10978	173	37	phenformin	phenformin	NOUN
ajst-10978	173	38	efficacy	efficacy	NOUN
ajst-10978	173	39	in	in	ADP
ajst-10978	173	40	breast	breast	NOUN
ajst-10978	173	41	cancer	cancer	NOUN
ajst-10978	173	42	.	.	PUNCT
ajst-10978	174	1	nat	nat	PROPN
ajst-10978	174	2	commun	commun	PROPN
ajst-10978	174	3	.	.	PUNCT
ajst-10978	174	4	2021	2021	NUM
ajst-10978	174	5	;	;	PUNCT
ajst-10978	174	6	12:3299	12:3299	X
ajst-10978	174	7	.	.	PUNCT
ajst-10978	175	1	[	[	X
ajst-10978	175	2	31	31	NUM
ajst-10978	175	3	]	]	PUNCT
ajst-10978	175	4	nair	nair	NOUN
ajst-10978	175	5	vs	vs	ADP
ajst-10978	175	6	,	,	PUNCT
ajst-10978	175	7	elkord	elkord	PROPN
ajst-10978	175	8	e.	e.	PROPN
ajst-10978	175	9	immune	immune	PROPN
ajst-10978	175	10	checkpoint	checkpoint	NOUN
ajst-10978	175	11	inhibitors	inhibitor	NOUN
ajst-10978	175	12	in	in	ADP
ajst-10978	175	13	cancer	cancer	NOUN
ajst-10978	175	14	therapy	therapy	NOUN
ajst-10978	175	15	:	:	PUNCT
ajst-10978	175	16	a	a	DET
ajst-10978	175	17	focus	focus	NOUN
ajst-10978	175	18	on	on	ADP
ajst-10978	175	19	t	t	PROPN
ajst-10978	175	20	-	-	PUNCT
ajst-10978	175	21	regulatory	regulatory	ADJ
ajst-10978	175	22	cells	cell	NOUN
ajst-10978	175	23	(	(	PUNCT
ajst-10978	175	24	vol	vol	NOUN
ajst-10978	175	25	96	96	NUM
ajst-10978	175	26	,	,	PUNCT
ajst-10978	175	27	pg	pg	NOUN
ajst-10978	175	28	21	21	NUM
ajst-10978	175	29	,	,	PUNCT
ajst-10978	175	30	2018	2018	NUM
ajst-10978	175	31	)	)	PUNCT
ajst-10978	175	32	.	.	PUNCT
ajst-10978	176	1	immunology	immunology	NOUN
ajst-10978	176	2	and	and	CCONJ
ajst-10978	176	3	cell	cell	NOUN
ajst-10978	176	4	biology	biology	NOUN
ajst-10978	176	5	2018;96:236	2018;96:236	PROPN
ajst-10978	176	6	-	-	NUM
ajst-10978	176	7	236	236	NUM
ajst-10978	176	8	.	.	PUNCT
ajst-10978	177	1	[	[	X
ajst-10978	177	2	32	32	NUM
ajst-10978	177	3	]	]	X
ajst-10978	177	4	chaudhary	chaudhary	PROPN
ajst-10978	177	5	b	b	PROPN
ajst-10978	177	6	,	,	PUNCT
ajst-10978	177	7	elkord	elkord	PROPN
ajst-10978	177	8	e.	e.	PROPN
ajst-10978	177	9	regulatory	regulatory	PROPN
ajst-10978	177	10	t	t	PROPN
ajst-10978	177	11	cells	cell	NOUN
ajst-10978	177	12	in	in	ADP
ajst-10978	177	13	the	the	DET
ajst-10978	177	14	tumor	tumor	NOUN
ajst-10978	177	15	microenvironment	microenvironment	NOUN
ajst-10978	177	16	and	and	CCONJ
ajst-10978	177	17	cancer	cancer	NOUN
ajst-10978	177	18	progression	progression	NOUN
ajst-10978	177	19	:	:	PUNCT
ajst-10978	177	20	role	role	NOUN
ajst-10978	177	21	and	and	CCONJ
ajst-10978	177	22	therapeutic	therapeutic	ADJ
ajst-10978	177	23	targeting	targeting	NOUN
ajst-10978	177	24	.	.	PUNCT
ajst-10978	178	1	vaccines	vaccine	NOUN
ajst-10978	178	2	.	.	PUNCT
ajst-10978	179	1	2016	2016	NUM
ajst-10978	179	2	;	;	PUNCT
ajst-10978	179	3	4	4	NUM
ajst-10978	179	4	.	.	PUNCT
ajst-10978	180	1	[	[	X
ajst-10978	180	2	33	33	NUM
ajst-10978	180	3	]	]	PUNCT
ajst-10978	180	4	nair	nair	NOUN
ajst-10978	180	5	vs	vs	ADP
ajst-10978	180	6	,	,	PUNCT
ajst-10978	180	7	el	el	PROPN
ajst-10978	180	8	salhat	salhat	PROPN
ajst-10978	180	9	h	h	PROPN
ajst-10978	180	10	,	,	PUNCT
ajst-10978	180	11	taha	taha	PROPN
ajst-10978	180	12	rz	rz	PROPN
ajst-10978	180	13	,	,	PUNCT
ajst-10978	180	14	john	john	PROPN
ajst-10978	180	15	a	a	PROPN
ajst-10978	180	16	,	,	PUNCT
ajst-10978	180	17	ali	ali	PROPN
ajst-10978	180	18	br	br	PROPN
ajst-10978	180	19	,	,	PUNCT
ajst-10978	180	20	elkord	elkord	PROPN
ajst-10978	180	21	e.	e.	PROPN
ajst-10978	180	22	dna	dna	PROPN
ajst-10978	180	23	methylation	methylation	NOUN
ajst-10978	180	24	and	and	CCONJ
ajst-10978	180	25	repressive	repressive	ADJ
ajst-10978	180	26	h3k9	h3k9	PROPN
ajst-10978	180	27	and	and	CCONJ
ajst-10978	180	28	h3k27	h3k27	PROPN
ajst-10978	180	29	trimethylation	trimethylation	NOUN
ajst-10978	180	30	in	in	ADP
ajst-10978	180	31	the	the	DET
ajst-10978	180	32	promoter	promoter	NOUN
ajst-10978	180	33	regions	region	NOUN
ajst-10978	180	34	of	of	ADP
ajst-10978	180	35	pd-1	pd-1	ADV
ajst-10978	180	36	,	,	PUNCT
ajst-10978	180	37	ctla-4	ctla-4	PROPN
ajst-10978	180	38	,	,	PUNCT
ajst-10978	180	39	tim	tim	PROPN
ajst-10978	180	40	8	8	NUM
ajst-10978	180	41	3	3	NUM
ajst-10978	180	42	,	,	PUNCT
ajst-10978	180	43	lag-3	lag-3	NUM
ajst-10978	180	44	,	,	PUNCT
ajst-10978	180	45	tigit	tigit	NOUN
ajst-10978	180	46	,	,	PUNCT
ajst-10978	180	47	and	and	CCONJ
ajst-10978	180	48	pd	pd	PROPN
ajst-10978	180	49	-	-	PUNCT
ajst-10978	180	50	l1	l1	PROPN
ajst-10978	180	51	genes	gene	NOUN
ajst-10978	180	52	in	in	ADP
ajst-10978	180	53	human	human	ADJ
ajst-10978	180	54	primary	primary	ADJ
ajst-10978	180	55	breast	breast	NOUN
ajst-10978	180	56	cancer	cancer	NOUN
ajst-10978	180	57	.	.	PUNCT
ajst-10978	181	1	clinical	clinical	ADJ
ajst-10978	181	2	epigenetics	epigenetic	NOUN
ajst-10978	181	3	.	.	PUNCT
ajst-10978	181	4	2018	2018	NUM
ajst-10978	181	5	;	;	PUNCT
ajst-10978	181	6	10	10	NUM
ajst-10978	181	7	.	.	PUNCT
ajst-10978	182	1	[	[	X
ajst-10978	182	2	34	34	NUM
ajst-10978	182	3	]	]	X
ajst-10978	182	4	saleh	saleh	NOUN
ajst-10978	182	5	r	r	PROPN
ajst-10978	182	6	,	,	PUNCT
ajst-10978	182	7	toor	toor	PROPN
ajst-10978	182	8	sm	sm	PROPN
ajst-10978	182	9	,	,	PUNCT
ajst-10978	182	10	khalaf	khalaf	PROPN
ajst-10978	182	11	s	s	PROPN
ajst-10978	182	12	,	,	PUNCT
ajst-10978	182	13	elkord	elkord	PROPN
ajst-10978	182	14	e.	e.	PROPN
ajst-10978	182	15	breast	breast	PROPN
ajst-10978	182	16	cancer	cancer	NOUN
ajst-10978	182	17	cells	cell	NOUN
ajst-10978	182	18	and	and	CCONJ
ajst-10978	182	19	pd-1	pd-1	ADP
ajst-10978	182	20	/	/	SYM
ajst-10978	182	21	pd	pd	ADJ
ajst-10978	182	22	-	-	PUNCT
ajst-10978	182	23	l1	l1	PROPN
ajst-10978	182	24	blockade	blockade	NOUN
ajst-10978	182	25	upregulate	upregulate	VERB
ajst-10978	182	26	the	the	DET
ajst-10978	182	27	expression	expression	NOUN
ajst-10978	182	28	of	of	ADP
ajst-10978	182	29	pd-1	pd-1	ADP
ajst-10978	182	30	,	,	PUNCT
ajst-10978	182	31	ctla-4	ctla-4	PROPN
ajst-10978	182	32	,	,	PUNCT
ajst-10978	182	33	tim-3	tim-3	X
ajst-10978	182	34	and	and	CCONJ
ajst-10978	182	35	lag-3	lag-3	PUNCT
ajst-10978	182	36	immune	immune	ADJ
ajst-10978	182	37	checkpoints	checkpoint	NOUN
ajst-10978	182	38	in	in	ADP
ajst-10978	182	39	cd4(+	cd4(+	NOUN
ajst-10978	182	40	)	)	PUNCT
ajst-10978	182	41	t	t	NOUN
ajst-10978	182	42	cells	cell	NOUN
ajst-10978	182	43	.	.	PUNCT
ajst-10978	183	1	vaccines	vaccine	NOUN
ajst-10978	183	2	.	.	PUNCT
ajst-10978	184	1	2019	2019	NUM
ajst-10978	184	2	;	;	PUNCT
ajst-10978	184	3	7	7	X
ajst-10978	184	4	.	.	PUNCT
ajst-10978	185	1	[	[	X
ajst-10978	185	2	35	35	NUM
ajst-10978	185	3	]	]	SYM
ajst-10978	185	4	ibuki	ibuki	PROPN
ajst-10978	185	5	y	y	PROPN
ajst-10978	185	6	,	,	PUNCT
ajst-10978	185	7	takahashi	takahashi	PROPN
ajst-10978	185	8	y	y	PROPN
ajst-10978	185	9	,	,	PUNCT
ajst-10978	185	10	tamari	tamari	ADJ
ajst-10978	185	11	k	k	PROPN
ajst-10978	185	12	,	,	PUNCT
ajst-10978	185	13	minami	minami	PROPN
ajst-10978	185	14	k	k	PROPN
ajst-10978	185	15	,	,	PUNCT
ajst-10978	185	16	seo	seo	PROPN
ajst-10978	185	17	y	y	PROPN
ajst-10978	185	18	,	,	PUNCT
ajst-10978	185	19	isohashi	isohashi	PROPN
ajst-10978	185	20	f	f	PROPN
ajst-10978	185	21	,	,	PUNCT
ajst-10978	185	22	et	et	PROPN
ajst-10978	185	23	al	al	PROPN
ajst-10978	185	24	.	.	PROPN
ajst-10978	186	1	local	local	ADJ
ajst-10978	186	2	hyperthermia	hyperthermia	NOUN
ajst-10978	186	3	combined	combine	VERB
ajst-10978	186	4	with	with	ADP
ajst-10978	186	5	ctla-4	ctla-4	NOUN
ajst-10978	186	6	blockade	blockade	NOUN
ajst-10978	186	7	induces	induce	VERB
ajst-10978	186	8	both	both	CCONJ
ajst-10978	186	9	local	local	ADJ
ajst-10978	186	10	and	and	CCONJ
ajst-10978	186	11	abscopal	abscopal	ADJ
ajst-10978	186	12	effects	effect	NOUN
ajst-10978	186	13	in	in	ADP
ajst-10978	186	14	a	a	DET
ajst-10978	186	15	murine	murine	ADJ
ajst-10978	186	16	breast	breast	NOUN
ajst-10978	186	17	cancer	cancer	NOUN
ajst-10978	186	18	model	model	NOUN
ajst-10978	186	19	.	.	PUNCT
ajst-10978	187	1	international	international	ADJ
ajst-10978	187	2	journal	journal	PROPN
ajst-10978	187	3	of	of	ADP
ajst-10978	187	4	hyperthermia	hyperthermia	NOUN
ajst-10978	187	5	.	.	PUNCT
ajst-10978	188	1	2021	2021	NUM
ajst-10978	188	2	;	;	PUNCT
ajst-10978	188	3	38:363	38:363	NUM
ajst-10978	188	4	-	-	SYM
ajst-10978	188	5	371	371	NUM
ajst-10978	188	6	.	.	PUNCT
ajst-10978	189	1	[	[	X
ajst-10978	189	2	36	36	NUM
ajst-10978	189	3	]	]	X
ajst-10978	189	4	du	du	PROPN
ajst-10978	189	5	hm	hm	INTJ
ajst-10978	189	6	,	,	PUNCT
ajst-10978	189	7	yi	yi	PROPN
ajst-10978	189	8	zy	zy	PROPN
ajst-10978	189	9	,	,	PUNCT
ajst-10978	189	10	wang	wang	PROPN
ajst-10978	189	11	l	l	PROPN
ajst-10978	189	12	,	,	PUNCT
ajst-10978	189	13	li	li	PROPN
ajst-10978	189	14	z	z	PROPN
ajst-10978	189	15	,	,	PUNCT
ajst-10978	189	16	niu	niu	PROPN
ajst-10978	189	17	bl	bl	PROPN
ajst-10978	189	18	,	,	PUNCT
ajst-10978	189	19	ren	ren	PROPN
ajst-10978	189	20	gs	gs	INTJ
ajst-10978	189	21	.	.	PUNCT
ajst-10978	190	1	the	the	DET
ajst-10978	190	2	coexpression	coexpression	NOUN
ajst-10978	190	3	characteristics	characteristic	NOUN
ajst-10978	190	4	of	of	ADP
ajst-10978	190	5	lag3	lag3	PROPN
ajst-10978	190	6	and	and	CCONJ
ajst-10978	190	7	pd-1	pd-1	ADV
ajst-10978	190	8	on	on	ADP
ajst-10978	190	9	the	the	DET
ajst-10978	190	10	t	t	NOUN
ajst-10978	190	11	cells	cell	NOUN
ajst-10978	190	12	of	of	ADP
ajst-10978	190	13	patients	patient	NOUN
ajst-10978	190	14	with	with	ADP
ajst-10978	190	15	breast	breast	NOUN
ajst-10978	190	16	cancer	cancer	NOUN
ajst-10978	190	17	reveal	reveal	VERB
ajst-10978	190	18	a	a	DET
ajst-10978	190	19	new	new	ADJ
ajst-10978	190	20	therapeutic	therapeutic	ADJ
ajst-10978	190	21	strategy	strategy	NOUN
ajst-10978	190	22	.	.	PUNCT
ajst-10978	191	1	international	international	ADJ
ajst-10978	191	2	immunopharmacology	immunopharmacology	NOUN
ajst-10978	191	3	.	.	PUNCT
ajst-10978	192	1	2020	2020	NUM
ajst-10978	192	2	;	;	PUNCT
ajst-10978	192	3	78	78	NUM
ajst-10978	192	4	.	.	PUNCT
ajst-10978	193	1	[	[	X
ajst-10978	193	2	37	37	NUM
ajst-10978	193	3	]	]	PUNCT
ajst-10978	193	4	ye	ye	PRON
ajst-10978	193	5	q	q	NOUN
ajst-10978	193	6	,	,	PUNCT
ajst-10978	193	7	wang	wang	PROPN
ajst-10978	193	8	cl	cl	PROPN
ajst-10978	193	9	,	,	PUNCT
ajst-10978	193	10	xian	xian	PROPN
ajst-10978	193	11	j	j	PROPN
ajst-10978	193	12	,	,	PUNCT
ajst-10978	193	13	zhang	zhang	PROPN
ajst-10978	193	14	m	m	PROPN
ajst-10978	193	15	,	,	PUNCT
ajst-10978	193	16	cao	cao	PROPN
ajst-10978	193	17	yj	yj	PROPN
ajst-10978	193	18	,	,	PUNCT
ajst-10978	193	19	cao	cao	PROPN
ajst-10978	193	20	yd	yd	PROPN
ajst-10978	193	21	.	.	PUNCT
ajst-10978	193	22	expression	expression	NOUN
ajst-10978	193	23	of	of	ADP
ajst-10978	193	24	programmed	program	VERB
ajst-10978	193	25	cell	cell	NOUN
ajst-10978	193	26	death	death	NOUN
ajst-10978	193	27	protein	protein	NOUN
ajst-10978	193	28	1	1	NUM
ajst-10978	193	29	(	(	PUNCT
ajst-10978	193	30	pd-1	pd-1	ADV
ajst-10978	193	31	)	)	PUNCT
ajst-10978	193	32	and	and	CCONJ
ajst-10978	193	33	indoleamine	indoleamine	VERB
ajst-10978	193	34	2,3	2,3	NUM
ajst-10978	193	35	-	-	NOUN
ajst-10978	193	36	dioxygenase	dioxygenase	NOUN
ajst-10978	193	37	(	(	PUNCT
ajst-10978	193	38	ido	ido	NOUN
ajst-10978	193	39	)	)	PUNCT
ajst-10978	193	40	in	in	ADP
ajst-10978	193	41	the	the	DET
ajst-10978	193	42	tumor	tumor	NOUN
ajst-10978	193	43	microenvironment	microenvironment	NOUN
ajst-10978	193	44	and	and	CCONJ
ajst-10978	193	45	in	in	ADP
ajst-10978	193	46	tumor	tumor	NOUN
ajst-10978	193	47	-	-	PUNCT
ajst-10978	193	48	draining	drain	VERB
ajst-10978	193	49	lymph	lymph	NOUN
ajst-10978	193	50	nodes	node	NOUN
ajst-10978	193	51	of	of	ADP
ajst-10978	193	52	breast	breast	NOUN
ajst-10978	193	53	cancer	cancer	NOUN
ajst-10978	193	54	.	.	PUNCT
ajst-10978	194	1	human	human	ADJ
ajst-10978	194	2	pathology	pathology	NOUN
ajst-10978	194	3	.	.	PUNCT
ajst-10978	195	1	2018	2018	NUM
ajst-10978	195	2	;	;	PUNCT
ajst-10978	195	3	75:81	75:81	NUM
ajst-10978	195	4	-	-	SYM
ajst-10978	195	5	90	90	NUM
ajst-10978	195	6	.	.	PUNCT
ajst-10978	196	1	[	[	X
ajst-10978	196	2	38	38	NUM
ajst-10978	196	3	]	]	PUNCT
ajst-10978	196	4	sivapiragasam	sivapiragasam	NOUN
ajst-10978	196	5	a	a	PRON
ajst-10978	196	6	,	,	PUNCT
ajst-10978	196	7	ashok	ashok	PROPN
ajst-10978	196	8	kumar	kumar	PROPN
ajst-10978	196	9	p	p	PROPN
ajst-10978	196	10	,	,	PUNCT
ajst-10978	196	11	sokol	sokol	PROPN
ajst-10978	196	12	es	es	PROPN
ajst-10978	196	13	,	,	PUNCT
ajst-10978	196	14	albacker	albacker	PROPN
ajst-10978	196	15	la	la	PROPN
ajst-10978	196	16	,	,	PUNCT
ajst-10978	196	17	killian	killian	PROPN
ajst-10978	196	18	jk	jk	PROPN
ajst-10978	196	19	,	,	PUNCT
ajst-10978	196	20	ramkissoon	ramkissoon	PROPN
ajst-10978	196	21	sh	sh	PROPN
ajst-10978	196	22	,	,	PUNCT
ajst-10978	196	23	et	et	PROPN
ajst-10978	196	24	al	al	PROPN
ajst-10978	196	25	.	.	PUNCT
ajst-10978	197	1	predictive	predictive	ADJ
ajst-10978	197	2	biomarkers	biomarker	NOUN
ajst-10978	197	3	for	for	ADP
ajst-10978	197	4	immune	immune	ADJ
ajst-10978	197	5	checkpoint	checkpoint	NOUN
ajst-10978	197	6	inhibitors	inhibitor	NOUN
ajst-10978	197	7	in	in	ADP
ajst-10978	197	8	metastatic	metastatic	ADJ
ajst-10978	197	9	breast	breast	NOUN
ajst-10978	197	10	cancer	cancer	NOUN
ajst-10978	197	11	.	.	PUNCT
ajst-10978	198	1	cancer	cancer	NOUN
ajst-10978	198	2	med	med	PROPN
ajst-10978	198	3	.	.	PROPN
ajst-10978	198	4	2021	2021	NUM
ajst-10978	198	5	;	;	PUNCT
ajst-10978	198	6	10:53	10:53	NUM
ajst-10978	198	7	-	-	SYM
ajst-10978	198	8	61	61	NUM
ajst-10978	198	9	.	.	PUNCT
ajst-10978	199	1	[	[	X
ajst-10978	199	2	39	39	NUM
ajst-10978	199	3	]	]	PUNCT
ajst-10978	199	4	bottai	bottai	PROPN
ajst-10978	199	5	g	g	PROPN
ajst-10978	199	6	,	,	PUNCT
ajst-10978	199	7	raschioni	raschioni	VERB
ajst-10978	199	8	c	c	NOUN
ajst-10978	199	9	,	,	PUNCT
ajst-10978	199	10	losurdo	losurdo	NOUN
ajst-10978	199	11	a	a	PRON
ajst-10978	199	12	,	,	PUNCT
ajst-10978	199	13	di	di	PROPN
ajst-10978	199	14	tommaso	tommaso	PROPN
ajst-10978	199	15	l	l	PROPN
ajst-10978	199	16	,	,	PUNCT
ajst-10978	199	17	tinterri	tinterri	PROPN
ajst-10978	199	18	c	c	NOUN
ajst-10978	199	19	,	,	PUNCT
ajst-10978	199	20	torrisi	torrisi	ADJ
ajst-10978	199	21	r	r	NOUN
ajst-10978	199	22	,	,	PUNCT
ajst-10978	199	23	et	et	PROPN
ajst-10978	199	24	al	al	PROPN
ajst-10978	199	25	.	.	PUNCT
ajst-10978	200	1	an	an	DET
ajst-10978	200	2	immune	immune	ADJ
ajst-10978	200	3	stratification	stratification	NOUN
ajst-10978	200	4	reveals	reveal	VERB
ajst-10978	200	5	a	a	DET
ajst-10978	200	6	subset	subset	NOUN
ajst-10978	200	7	of	of	ADP
ajst-10978	200	8	pd-1	pd-1	ADP
ajst-10978	200	9	/	/	SYM
ajst-10978	200	10	lag-3	lag-3	PUNCT
ajst-10978	200	11	double	double	ADJ
ajst-10978	200	12	-	-	PUNCT
ajst-10978	200	13	positive	positive	ADJ
ajst-10978	200	14	triple	triple	ADJ
ajst-10978	200	15	-	-	PUNCT
ajst-10978	200	16	negative	negative	ADJ
ajst-10978	200	17	breast	breast	NOUN
ajst-10978	200	18	cancers	cancer	NOUN
ajst-10978	200	19	.	.	PUNCT
ajst-10978	201	1	breast	breast	NOUN
ajst-10978	201	2	cancer	cancer	NOUN
ajst-10978	201	3	res	re	NOUN
ajst-10978	201	4	.	.	PROPN
ajst-10978	201	5	2016	2016	NUM
ajst-10978	201	6	;	;	PUNCT
ajst-10978	201	7	18:121	18:121	NUM
ajst-10978	201	8	.	.	PUNCT