id	sid	tid	token	lemma	pos
ajst-17938	1	1	academic	academic	ADJ
ajst-17938	1	2	journal	journal	NOUN
ajst-17938	1	3	of	of	ADP
ajst-17938	1	4	science	science	NOUN
ajst-17938	1	5	and	and	CCONJ
ajst-17938	1	6	technology	technology	NOUN
ajst-17938	1	7	issn	issn	NOUN
ajst-17938	1	8	:	:	PUNCT
ajst-17938	1	9	2771	2771	NUM
ajst-17938	1	10	-	-	SYM
ajst-17938	1	11	3032	3032	NUM
ajst-17938	1	12	|	|	NOUN
ajst-17938	1	13	vol	vol	NOUN
ajst-17938	1	14	.	.	PROPN
ajst-17938	2	1	9	9	NUM
ajst-17938	2	2	,	,	PUNCT
ajst-17938	2	3	no	no	INTJ
ajst-17938	2	4	.	.	NOUN
ajst-17938	2	5	2	2	NUM
ajst-17938	2	6	,	,	PUNCT
ajst-17938	2	7	2024	2024	NUM
ajst-17938	2	8	261	261	NUM
ajst-17938	2	9	development	development	NOUN
ajst-17938	2	10	of	of	ADP
ajst-17938	2	11	anti‐metastatic	anti‐metastatic	ADJ
ajst-17938	2	12	drugs	drug	NOUN
ajst-17938	2	13	based	base	VERB
ajst-17938	2	14	on	on	ADP
ajst-17938	2	15	banned	ban	VERB
ajst-17938	2	16	imide‐polyamine	imide‐polyamine	NOUN
ajst-17938	2	17	conjugates	conjugate	NOUN
ajst-17938	2	18	and	and	CCONJ
ajst-17938	2	19	their	their	PRON
ajst-17938	2	20	application	application	NOUN
ajst-17938	2	21	in	in	ADP
ajst-17938	2	22	the	the	DET
ajst-17938	2	23	treatment	treatment	NOUN
ajst-17938	2	24	of	of	ADP
ajst-17938	2	25	liver	liver	NOUN
ajst-17938	2	26	cancer	cancer	NOUN
ajst-17938	2	27	dianwen	dianwen	NOUN
ajst-17938	2	28	yang1	yang1	PROPN
ajst-17938	2	29	,	,	PUNCT
ajst-17938	2	30	a	a	DET
ajst-17938	2	31	1shanghai	1shanghai	NUM
ajst-17938	2	32	feiyue	feiyue	NOUN
ajst-17938	2	33	pharmaceutical	pharmaceutical	PROPN
ajst-17938	2	34	technology	technology	PROPN
ajst-17938	2	35	co.	co.	PROPN
ajst-17938	2	36	,	,	PUNCT
ajst-17938	2	37	ltd	ltd	PROPN
ajst-17938	2	38	,	,	PUNCT
ajst-17938	2	39	shanghai	shanghai	PROPN
ajst-17938	2	40	,	,	PUNCT
ajst-17938	2	41	china	china	PROPN
ajst-17938	2	42	a1935020607@st.usst.edu.cn	a1935020607@st.usst.edu.cn	PROPN
ajst-17938	2	43	abstract	abstract	NOUN
ajst-17938	2	44	:	:	PUNCT
ajst-17938	2	45	the	the	DET
ajst-17938	2	46	purpose	purpose	NOUN
ajst-17938	2	47	of	of	ADP
ajst-17938	2	48	this	this	DET
ajst-17938	2	49	study	study	NOUN
ajst-17938	2	50	was	be	AUX
ajst-17938	2	51	to	to	PART
ajst-17938	2	52	develop	develop	VERB
ajst-17938	2	53	an	an	DET
ajst-17938	2	54	anti	anti	ADJ
ajst-17938	2	55	-	-	ADJ
ajst-17938	2	56	metastasis	metastasis	ADJ
ajst-17938	2	57	drug	drug	NOUN
ajst-17938	2	58	based	base	VERB
ajst-17938	2	59	on	on	ADP
ajst-17938	2	60	a	a	DET
ajst-17938	2	61	banned	ban	VERB
ajst-17938	2	62	imide	imide	ADJ
ajst-17938	2	63	-	-	PUNCT
ajst-17938	2	64	polyamine	polyamine	NOUN
ajst-17938	2	65	conjugate	conjugate	NOUN
ajst-17938	2	66	and	and	CCONJ
ajst-17938	2	67	to	to	PART
ajst-17938	2	68	explore	explore	VERB
ajst-17938	2	69	its	its	PRON
ajst-17938	2	70	application	application	NOUN
ajst-17938	2	71	in	in	ADP
ajst-17938	2	72	the	the	DET
ajst-17938	2	73	treatment	treatment	NOUN
ajst-17938	2	74	of	of	ADP
ajst-17938	2	75	liver	liver	NOUN
ajst-17938	2	76	cancer	cancer	NOUN
ajst-17938	2	77	.	.	PUNCT
ajst-17938	3	1	first	first	ADV
ajst-17938	3	2	,	,	PUNCT
ajst-17938	3	3	we	we	PRON
ajst-17938	3	4	designed	design	VERB
ajst-17938	3	5	and	and	CCONJ
ajst-17938	3	6	synthesized	synthesize	VERB
ajst-17938	3	7	a	a	DET
ajst-17938	3	8	series	series	NOUN
ajst-17938	3	9	of	of	ADP
ajst-17938	3	10	forbidden	forbid	VERB
ajst-17938	3	11	imidepolyamine	imidepolyamine	ADJ
ajst-17938	3	12	conjugates	conjugate	NOUN
ajst-17938	3	13	and	and	CCONJ
ajst-17938	3	14	evaluated	evaluate	VERB
ajst-17938	3	15	their	their	PRON
ajst-17938	3	16	inhibitory	inhibitory	ADJ
ajst-17938	3	17	effects	effect	NOUN
ajst-17938	3	18	on	on	ADP
ajst-17938	3	19	the	the	DET
ajst-17938	3	20	migration	migration	NOUN
ajst-17938	3	21	and	and	CCONJ
ajst-17938	3	22	invasion	invasion	NOUN
ajst-17938	3	23	capacity	capacity	NOUN
ajst-17938	3	24	of	of	ADP
ajst-17938	3	25	hcc	hcc	PROPN
ajst-17938	3	26	cells	cell	NOUN
ajst-17938	3	27	by	by	ADP
ajst-17938	3	28	cell	cell	NOUN
ajst-17938	3	29	assay	assay	NOUN
ajst-17938	3	30	.	.	PUNCT
ajst-17938	4	1	the	the	DET
ajst-17938	4	2	results	result	NOUN
ajst-17938	4	3	showed	show	VERB
ajst-17938	4	4	that	that	SCONJ
ajst-17938	4	5	these	these	DET
ajst-17938	4	6	compounds	compound	NOUN
ajst-17938	4	7	were	be	AUX
ajst-17938	4	8	able	able	ADJ
ajst-17938	4	9	to	to	PART
ajst-17938	4	10	significantly	significantly	ADV
ajst-17938	4	11	reduce	reduce	VERB
ajst-17938	4	12	the	the	DET
ajst-17938	4	13	metastatic	metastatic	ADJ
ajst-17938	4	14	ability	ability	NOUN
ajst-17938	4	15	of	of	ADP
ajst-17938	4	16	hcc	hcc	PROPN
ajst-17938	4	17	cells	cell	NOUN
ajst-17938	4	18	.	.	PUNCT
ajst-17938	5	1	further	further	PROPN
ajst-17938	5	2	mechanistic	mechanistic	ADJ
ajst-17938	5	3	studies	study	NOUN
ajst-17938	5	4	revealed	reveal	VERB
ajst-17938	5	5	that	that	SCONJ
ajst-17938	5	6	these	these	DET
ajst-17938	5	7	compounds	compound	NOUN
ajst-17938	5	8	are	be	AUX
ajst-17938	5	9	able	able	ADJ
ajst-17938	5	10	to	to	PART
ajst-17938	5	11	inhibit	inhibit	VERB
ajst-17938	5	12	the	the	DET
ajst-17938	5	13	metastasis	metastasis	NOUN
ajst-17938	5	14	of	of	ADP
ajst-17938	5	15	hcc	hcc	PROPN
ajst-17938	5	16	cells	cell	NOUN
ajst-17938	5	17	by	by	ADP
ajst-17938	5	18	interfering	interfere	VERB
ajst-17938	5	19	with	with	ADP
ajst-17938	5	20	intracellular	intracellular	ADJ
ajst-17938	5	21	signaling	signal	VERB
ajst-17938	5	22	pathways	pathway	NOUN
ajst-17938	5	23	and	and	CCONJ
ajst-17938	5	24	affecting	affect	VERB
ajst-17938	5	25	cytoskeletal	cytoskeletal	ADJ
ajst-17938	5	26	reorganization	reorganization	NOUN
ajst-17938	5	27	.	.	PUNCT
ajst-17938	6	1	these	these	DET
ajst-17938	6	2	compounds	compound	NOUN
ajst-17938	6	3	also	also	ADV
ajst-17938	6	4	showed	show	VERB
ajst-17938	6	5	promising	promise	VERB
ajst-17938	6	6	anti	anti	ADJ
ajst-17938	6	7	-	-	ADJ
ajst-17938	6	8	hcc	hcc	ADJ
ajst-17938	6	9	metastatic	metastatic	ADJ
ajst-17938	6	10	effects	effect	NOUN
ajst-17938	6	11	in	in	ADP
ajst-17938	6	12	animal	animal	NOUN
ajst-17938	6	13	models	model	NOUN
ajst-17938	6	14	.	.	PUNCT
ajst-17938	7	1	to	to	PART
ajst-17938	7	2	further	far	ADV
ajst-17938	7	3	optimize	optimize	VERB
ajst-17938	7	4	the	the	DET
ajst-17938	7	5	structure	structure	NOUN
ajst-17938	7	6	and	and	CCONJ
ajst-17938	7	7	activity	activity	NOUN
ajst-17938	7	8	of	of	ADP
ajst-17938	7	9	these	these	DET
ajst-17938	7	10	compounds	compound	NOUN
ajst-17938	7	11	,	,	PUNCT
ajst-17938	7	12	we	we	PRON
ajst-17938	7	13	optimized	optimize	VERB
ajst-17938	7	14	their	their	PRON
ajst-17938	7	15	structures	structure	NOUN
ajst-17938	7	16	using	use	VERB
ajst-17938	7	17	computer	computer	NOUN
ajst-17938	7	18	-	-	PUNCT
ajst-17938	7	19	aided	aid	VERB
ajst-17938	7	20	design	design	NOUN
ajst-17938	7	21	techniques	technique	NOUN
ajst-17938	7	22	.	.	PUNCT
ajst-17938	8	1	through	through	ADP
ajst-17938	8	2	molecular	molecular	ADJ
ajst-17938	8	3	docking	docking	NOUN
ajst-17938	8	4	and	and	CCONJ
ajst-17938	8	5	molecular	molecular	ADJ
ajst-17938	8	6	dynamics	dynamic	NOUN
ajst-17938	8	7	simulations	simulation	NOUN
ajst-17938	8	8	,	,	PUNCT
ajst-17938	8	9	we	we	PRON
ajst-17938	8	10	found	find	VERB
ajst-17938	8	11	a	a	DET
ajst-17938	8	12	number	number	NOUN
ajst-17938	8	13	of	of	ADP
ajst-17938	8	14	compounds	compound	NOUN
ajst-17938	8	15	with	with	ADP
ajst-17938	8	16	higher	high	ADJ
ajst-17938	8	17	activity	activity	NOUN
ajst-17938	8	18	and	and	CCONJ
ajst-17938	8	19	selectivity	selectivity	NOUN
ajst-17938	8	20	.	.	PUNCT
ajst-17938	9	1	these	these	DET
ajst-17938	9	2	optimized	optimize	VERB
ajst-17938	9	3	compounds	compound	NOUN
ajst-17938	9	4	further	far	ADV
ajst-17938	9	5	validate	validate	VERB
ajst-17938	9	6	their	their	PRON
ajst-17938	9	7	anti	anti	ADJ
ajst-17938	9	8	-	-	ADJ
ajst-17938	9	9	metastatic	metastatic	ADJ
ajst-17938	9	10	effect	effect	NOUN
ajst-17938	9	11	in	in	ADP
ajst-17938	9	12	cellular	cellular	ADJ
ajst-17938	9	13	experiments	experiment	NOUN
ajst-17938	9	14	and	and	CCONJ
ajst-17938	9	15	have	have	VERB
ajst-17938	9	16	less	less	ADJ
ajst-17938	9	17	effect	effect	NOUN
ajst-17938	9	18	on	on	ADP
ajst-17938	9	19	normal	normal	ADJ
ajst-17938	9	20	cells	cell	NOUN
ajst-17938	9	21	,	,	PUNCT
ajst-17938	9	22	showing	show	VERB
ajst-17938	9	23	better	well	ADJ
ajst-17938	9	24	biocompatibility	biocompatibility	NOUN
ajst-17938	9	25	.	.	PUNCT
ajst-17938	10	1	we	we	PRON
ajst-17938	10	2	also	also	ADV
ajst-17938	10	3	explored	explore	VERB
ajst-17938	10	4	the	the	DET
ajst-17938	10	5	mechanism	mechanism	NOUN
ajst-17938	10	6	of	of	ADP
ajst-17938	10	7	action	action	NOUN
ajst-17938	10	8	of	of	ADP
ajst-17938	10	9	these	these	DET
ajst-17938	10	10	compounds	compound	NOUN
ajst-17938	10	11	in	in	ADP
ajst-17938	10	12	hcc	hcc	PROPN
ajst-17938	10	13	treatment	treatment	NOUN
ajst-17938	10	14	.	.	PUNCT
ajst-17938	11	1	these	these	DET
ajst-17938	11	2	compounds	compound	NOUN
ajst-17938	11	3	were	be	AUX
ajst-17938	11	4	found	find	VERB
ajst-17938	11	5	to	to	PART
ajst-17938	11	6	be	be	AUX
ajst-17938	11	7	able	able	ADJ
ajst-17938	11	8	to	to	PART
ajst-17938	11	9	induce	induce	VERB
ajst-17938	11	10	apoptosis	apoptosis	NOUN
ajst-17938	11	11	in	in	ADP
ajst-17938	11	12	hcc	hcc	PROPN
ajst-17938	11	13	cells	cell	NOUN
ajst-17938	11	14	and	and	CCONJ
ajst-17938	11	15	to	to	PART
ajst-17938	11	16	inhibit	inhibit	VERB
ajst-17938	11	17	their	their	PRON
ajst-17938	11	18	proliferation	proliferation	NOUN
ajst-17938	11	19	.	.	PUNCT
ajst-17938	12	1	at	at	ADP
ajst-17938	12	2	the	the	DET
ajst-17938	12	3	same	same	ADJ
ajst-17938	12	4	time	time	NOUN
ajst-17938	12	5	,	,	PUNCT
ajst-17938	12	6	they	they	PRON
ajst-17938	12	7	can	can	AUX
ajst-17938	12	8	also	also	ADV
ajst-17938	12	9	promote	promote	VERB
ajst-17938	12	10	the	the	DET
ajst-17938	12	11	autophagy	autophagy	NOUN
ajst-17938	12	12	and	and	CCONJ
ajst-17938	12	13	cell	cell	NOUN
ajst-17938	12	14	cycle	cycle	NOUN
ajst-17938	12	15	arrest	arrest	NOUN
ajst-17938	12	16	of	of	ADP
ajst-17938	12	17	hcc	hcc	PROPN
ajst-17938	12	18	cells	cell	NOUN
ajst-17938	12	19	,	,	PUNCT
ajst-17938	12	20	thus	thus	ADV
ajst-17938	12	21	inhibiting	inhibit	VERB
ajst-17938	12	22	the	the	DET
ajst-17938	12	23	development	development	NOUN
ajst-17938	12	24	of	of	ADP
ajst-17938	12	25	hcc	hcc	PROPN
ajst-17938	12	26	in	in	ADP
ajst-17938	12	27	many	many	ADJ
ajst-17938	12	28	ways	way	NOUN
ajst-17938	12	29	.	.	PUNCT
ajst-17938	13	1	the	the	DET
ajst-17938	13	2	forbidden	forbid	VERB
ajst-17938	13	3	imide	imide	ADJ
ajst-17938	13	4	-	-	PUNCT
ajst-17938	13	5	polyamine	polyamine	NOUN
ajst-17938	13	6	conjugates	conjugate	NOUN
ajst-17938	13	7	developed	develop	VERB
ajst-17938	13	8	in	in	ADP
ajst-17938	13	9	this	this	DET
ajst-17938	13	10	study	study	NOUN
ajst-17938	13	11	have	have	VERB
ajst-17938	13	12	the	the	DET
ajst-17938	13	13	potential	potential	NOUN
ajst-17938	13	14	to	to	PART
ajst-17938	13	15	serve	serve	VERB
ajst-17938	13	16	as	as	ADP
ajst-17938	13	17	novel	novel	ADJ
ajst-17938	13	18	anti	anti	ADJ
ajst-17938	13	19	-	-	ADJ
ajst-17938	13	20	hcc	hcc	ADJ
ajst-17938	13	21	metastasis	metastasis	NOUN
ajst-17938	13	22	agents	agent	NOUN
ajst-17938	13	23	.	.	PUNCT
ajst-17938	14	1	in	in	ADP
ajst-17938	14	2	the	the	DET
ajst-17938	14	3	future	future	NOUN
ajst-17938	14	4	,	,	PUNCT
ajst-17938	14	5	we	we	PRON
ajst-17938	14	6	will	will	AUX
ajst-17938	14	7	continue	continue	VERB
ajst-17938	14	8	to	to	PART
ajst-17938	14	9	optimize	optimize	VERB
ajst-17938	14	10	the	the	DET
ajst-17938	14	11	structure	structure	NOUN
ajst-17938	14	12	and	and	CCONJ
ajst-17938	14	13	activity	activity	NOUN
ajst-17938	14	14	of	of	ADP
ajst-17938	14	15	these	these	DET
ajst-17938	14	16	compounds	compound	NOUN
ajst-17938	14	17	and	and	CCONJ
ajst-17938	14	18	conduct	conduct	VERB
ajst-17938	14	19	clinical	clinical	ADJ
ajst-17938	14	20	trials	trial	NOUN
ajst-17938	14	21	to	to	PART
ajst-17938	14	22	validate	validate	VERB
ajst-17938	14	23	their	their	PRON
ajst-17938	14	24	efficacy	efficacy	NOUN
ajst-17938	14	25	and	and	CCONJ
ajst-17938	14	26	safety	safety	NOUN
ajst-17938	14	27	.	.	PUNCT
ajst-17938	15	1	in	in	ADP
ajst-17938	15	2	addition	addition	NOUN
ajst-17938	15	3	,	,	PUNCT
ajst-17938	15	4	we	we	PRON
ajst-17938	15	5	will	will	AUX
ajst-17938	15	6	further	far	ADV
ajst-17938	15	7	explore	explore	VERB
ajst-17938	15	8	the	the	DET
ajst-17938	15	9	mechanisms	mechanism	NOUN
ajst-17938	15	10	of	of	ADP
ajst-17938	15	11	these	these	DET
ajst-17938	15	12	compounds	compound	NOUN
ajst-17938	15	13	in	in	ADP
ajst-17938	15	14	order	order	NOUN
ajst-17938	15	15	to	to	PART
ajst-17938	15	16	provide	provide	VERB
ajst-17938	15	17	new	new	ADJ
ajst-17938	15	18	strategies	strategy	NOUN
ajst-17938	15	19	for	for	ADP
ajst-17938	15	20	the	the	DET
ajst-17938	15	21	prevention	prevention	NOUN
ajst-17938	15	22	and	and	CCONJ
ajst-17938	15	23	treatment	treatment	NOUN
ajst-17938	15	24	of	of	ADP
ajst-17938	15	25	hcc	hcc	PROPN
ajst-17938	15	26	.	.	PUNCT
ajst-17938	16	1	keywords	keyword	NOUN
ajst-17938	16	2	:	:	PUNCT
ajst-17938	16	3	forbidden	forbid	VERB
ajst-17938	16	4	imide	imide	ADJ
ajst-17938	16	5	-	-	PUNCT
ajst-17938	16	6	polyamine	polyamine	NOUN
ajst-17938	16	7	conjugate	conjugate	NOUN
ajst-17938	16	8	;	;	PUNCT
ajst-17938	16	9	anti	anti	ADJ
ajst-17938	16	10	-	-	ADJ
ajst-17938	16	11	metastatic	metastatic	ADJ
ajst-17938	16	12	drug	drug	NOUN
ajst-17938	16	13	;	;	PUNCT
ajst-17938	16	14	development	development	NOUN
ajst-17938	16	15	;	;	PUNCT
ajst-17938	16	16	liver	liver	NOUN
ajst-17938	16	17	cancer	cancer	NOUN
ajst-17938	16	18	treatment	treatment	NOUN
ajst-17938	16	19	;	;	PUNCT
ajst-17938	16	20	application	application	NOUN
ajst-17938	16	21	.	.	PUNCT
ajst-17938	17	1	1	1	X
ajst-17938	17	2	.	.	X
ajst-17938	17	3	introduction	introduction	NOUN
ajst-17938	17	4	liver	liver	NOUN
ajst-17938	17	5	cancer	cancer	NOUN
ajst-17938	17	6	is	be	AUX
ajst-17938	17	7	one	one	NUM
ajst-17938	17	8	of	of	ADP
ajst-17938	17	9	the	the	DET
ajst-17938	17	10	most	most	ADV
ajst-17938	17	11	common	common	ADJ
ajst-17938	17	12	malignant	malignant	ADJ
ajst-17938	17	13	tumors	tumor	NOUN
ajst-17938	17	14	worldwide	worldwide	ADV
ajst-17938	17	15	,	,	PUNCT
ajst-17938	17	16	and	and	CCONJ
ajst-17938	17	17	its	its	PRON
ajst-17938	17	18	metastasis	metastasis	NOUN
ajst-17938	17	19	and	and	CCONJ
ajst-17938	17	20	recurrence	recurrence	NOUN
ajst-17938	17	21	are	be	AUX
ajst-17938	17	22	the	the	DET
ajst-17938	17	23	main	main	ADJ
ajst-17938	17	24	causes	cause	NOUN
ajst-17938	17	25	of	of	ADP
ajst-17938	17	26	death	death	NOUN
ajst-17938	17	27	in	in	ADP
ajst-17938	17	28	patients	patient	NOUN
ajst-17938	17	29	.	.	PUNCT
ajst-17938	18	1	therefore	therefore	ADV
ajst-17938	18	2	,	,	PUNCT
ajst-17938	18	3	finding	find	VERB
ajst-17938	18	4	effective	effective	ADJ
ajst-17938	18	5	antimetastatic	antimetastatic	ADJ
ajst-17938	18	6	drugs	drug	NOUN
ajst-17938	18	7	is	be	AUX
ajst-17938	18	8	important	important	ADJ
ajst-17938	18	9	for	for	ADP
ajst-17938	18	10	hcc	hcc	PROPN
ajst-17938	18	11	treatment	treatment	NOUN
ajst-17938	18	12	.	.	PUNCT
ajst-17938	19	1	banimidepolyamine	banimidepolyamine	NOUN
ajst-17938	19	2	conjugates	conjugate	NOUN
ajst-17938	19	3	are	be	AUX
ajst-17938	19	4	a	a	DET
ajst-17938	19	5	class	class	NOUN
ajst-17938	19	6	of	of	ADP
ajst-17938	19	7	compounds	compound	NOUN
ajst-17938	19	8	composed	compose	VERB
ajst-17938	19	9	of	of	ADP
ajst-17938	19	10	banned	ban	VERB
ajst-17938	19	11	imines	imine	NOUN
ajst-17938	19	12	and	and	CCONJ
ajst-17938	19	13	polyamines	polyamine	NOUN
ajst-17938	19	14	with	with	ADP
ajst-17938	19	15	unique	unique	ADJ
ajst-17938	19	16	structural	structural	ADJ
ajst-17938	19	17	and	and	CCONJ
ajst-17938	19	18	antitumor	antitumor	PROPN
ajst-17938	19	19	activities	activity	NOUN
ajst-17938	19	20	.	.	PUNCT
ajst-17938	20	1	this	this	DET
ajst-17938	20	2	class	class	NOUN
ajst-17938	20	3	of	of	ADP
ajst-17938	20	4	compounds	compound	NOUN
ajst-17938	20	5	can	can	AUX
ajst-17938	20	6	inhibit	inhibit	VERB
ajst-17938	20	7	the	the	DET
ajst-17938	20	8	growth	growth	NOUN
ajst-17938	20	9	and	and	CCONJ
ajst-17938	20	10	metastasis	metastasis	NOUN
ajst-17938	20	11	of	of	ADP
ajst-17938	20	12	tumor	tumor	NOUN
ajst-17938	20	13	cells	cell	NOUN
ajst-17938	20	14	by	by	ADP
ajst-17938	20	15	targeting	target	VERB
ajst-17938	20	16	specific	specific	ADJ
ajst-17938	20	17	receptors	receptor	NOUN
ajst-17938	20	18	for	for	ADP
ajst-17938	20	19	tumor	tumor	NOUN
ajst-17938	20	20	cells	cell	NOUN
ajst-17938	20	21	.	.	PUNCT
ajst-17938	21	1	first	first	ADV
ajst-17938	21	2	,	,	PUNCT
ajst-17938	21	3	they	they	PRON
ajst-17938	21	4	can	can	AUX
ajst-17938	21	5	inhibit	inhibit	VERB
ajst-17938	21	6	tumor	tumor	NOUN
ajst-17938	21	7	growth	growth	NOUN
ajst-17938	21	8	by	by	ADP
ajst-17938	21	9	inhibiting	inhibit	VERB
ajst-17938	21	10	the	the	DET
ajst-17938	21	11	proliferation	proliferation	NOUN
ajst-17938	21	12	of	of	ADP
ajst-17938	21	13	tumor	tumor	NOUN
ajst-17938	21	14	cells	cell	NOUN
ajst-17938	21	15	.	.	PUNCT
ajst-17938	22	1	these	these	DET
ajst-17938	22	2	compounds	compound	NOUN
ajst-17938	22	3	can	can	AUX
ajst-17938	22	4	interfere	interfere	VERB
ajst-17938	22	5	with	with	ADP
ajst-17938	22	6	the	the	DET
ajst-17938	22	7	dna	dna	PROPN
ajst-17938	22	8	synthesis	synthesis	NOUN
ajst-17938	22	9	and	and	CCONJ
ajst-17938	22	10	repair	repair	NOUN
ajst-17938	22	11	processes	process	NOUN
ajst-17938	22	12	in	in	ADP
ajst-17938	22	13	cells	cell	NOUN
ajst-17938	22	14	,	,	PUNCT
ajst-17938	22	15	leading	lead	VERB
ajst-17938	22	16	to	to	ADP
ajst-17938	22	17	dna	dna	PROPN
ajst-17938	22	18	damage	damage	NOUN
ajst-17938	22	19	and	and	CCONJ
ajst-17938	22	20	apoptosis	apoptosis	NOUN
ajst-17938	22	21	.	.	PUNCT
ajst-17938	23	1	secondly	secondly	ADV
ajst-17938	23	2	,	,	PUNCT
ajst-17938	23	3	forbidden	forbid	VERB
ajst-17938	23	4	imide	imide	ADJ
ajst-17938	23	5	-	-	PUNCT
ajst-17938	23	6	polyamine	polyamine	NOUN
ajst-17938	23	7	conjugates	conjugate	NOUN
ajst-17938	23	8	can	can	AUX
ajst-17938	23	9	inhibit	inhibit	VERB
ajst-17938	23	10	the	the	DET
ajst-17938	23	11	invasion	invasion	NOUN
ajst-17938	23	12	and	and	CCONJ
ajst-17938	23	13	metastatic	metastatic	ADJ
ajst-17938	23	14	capacity	capacity	NOUN
ajst-17938	23	15	of	of	ADP
ajst-17938	23	16	tumor	tumor	NOUN
ajst-17938	23	17	cells	cell	NOUN
ajst-17938	23	18	.	.	PUNCT
ajst-17938	24	1	they	they	PRON
ajst-17938	24	2	are	be	AUX
ajst-17938	24	3	able	able	ADJ
ajst-17938	24	4	to	to	PART
ajst-17938	24	5	inhibit	inhibit	VERB
ajst-17938	24	6	the	the	DET
ajst-17938	24	7	migration	migration	NOUN
ajst-17938	24	8	and	and	CCONJ
ajst-17938	24	9	invasion	invasion	NOUN
ajst-17938	24	10	of	of	ADP
ajst-17938	24	11	tumor	tumor	NOUN
ajst-17938	24	12	cells	cell	NOUN
ajst-17938	24	13	,	,	PUNCT
ajst-17938	24	14	thus	thus	ADV
ajst-17938	24	15	blocking	block	VERB
ajst-17938	24	16	the	the	DET
ajst-17938	24	17	tumor	tumor	NOUN
ajst-17938	24	18	metastasis	metastasis	NOUN
ajst-17938	24	19	process	process	NOUN
ajst-17938	24	20	.	.	PUNCT
ajst-17938	25	1	moreover	moreover	ADV
ajst-17938	25	2	,	,	PUNCT
ajst-17938	25	3	these	these	DET
ajst-17938	25	4	compounds	compound	NOUN
ajst-17938	25	5	can	can	AUX
ajst-17938	25	6	also	also	ADV
ajst-17938	25	7	modulate	modulate	VERB
ajst-17938	25	8	the	the	DET
ajst-17938	25	9	tumor	tumor	NOUN
ajst-17938	25	10	microenvironment	microenvironment	NOUN
ajst-17938	25	11	to	to	PART
ajst-17938	25	12	inhibit	inhibit	VERB
ajst-17938	25	13	tumor	tumor	NOUN
ajst-17938	25	14	angiogenesis	angiogenesis	NOUN
ajst-17938	25	15	and	and	CCONJ
ajst-17938	25	16	tumor	tumor	NOUN
ajst-17938	25	17	-	-	PUNCT
ajst-17938	25	18	associated	associate	VERB
ajst-17938	25	19	inflammatory	inflammatory	ADJ
ajst-17938	25	20	responses	response	NOUN
ajst-17938	25	21	,	,	PUNCT
ajst-17938	25	22	thereby	thereby	ADV
ajst-17938	25	23	preventing	prevent	VERB
ajst-17938	25	24	tumor	tumor	NOUN
ajst-17938	25	25	nutrient	nutrient	NOUN
ajst-17938	25	26	supply	supply	NOUN
ajst-17938	25	27	and	and	CCONJ
ajst-17938	25	28	growth	growth	NOUN
ajst-17938	25	29	.	.	PUNCT
ajst-17938	26	1	currently	currently	ADV
ajst-17938	26	2	,	,	PUNCT
ajst-17938	26	3	many	many	ADJ
ajst-17938	26	4	experimental	experimental	ADJ
ajst-17938	26	5	studies	study	NOUN
ajst-17938	26	6	have	have	AUX
ajst-17938	26	7	demonstrated	demonstrate	VERB
ajst-17938	26	8	the	the	DET
ajst-17938	26	9	antitumor	antitumor	PROPN
ajst-17938	26	10	activity	activity	NOUN
ajst-17938	26	11	of	of	ADP
ajst-17938	26	12	banned	ban	VERB
ajst-17938	26	13	imidepolyamine	imidepolyamine	ADJ
ajst-17938	26	14	conjugates	conjugate	NOUN
ajst-17938	26	15	against	against	ADP
ajst-17938	26	16	hcc	hcc	PROPN
ajst-17938	26	17	both	both	PRON
ajst-17938	26	18	in	in	ADP
ajst-17938	26	19	vitro	vitro	X
ajst-17938	26	20	and	and	CCONJ
ajst-17938	26	21	in	in	ADP
ajst-17938	26	22	vivo	vivo	NOUN
ajst-17938	26	23	.	.	PUNCT
ajst-17938	27	1	experimental	experimental	ADJ
ajst-17938	27	2	data	datum	NOUN
ajst-17938	27	3	showed	show	VERB
ajst-17938	27	4	that	that	SCONJ
ajst-17938	27	5	these	these	DET
ajst-17938	27	6	compounds	compound	NOUN
ajst-17938	27	7	could	could	AUX
ajst-17938	27	8	significantly	significantly	ADV
ajst-17938	27	9	inhibit	inhibit	VERB
ajst-17938	27	10	the	the	DET
ajst-17938	27	11	proliferation	proliferation	NOUN
ajst-17938	27	12	and	and	CCONJ
ajst-17938	27	13	invasion	invasion	NOUN
ajst-17938	27	14	of	of	ADP
ajst-17938	27	15	hcc	hcc	PROPN
ajst-17938	27	16	cells	cell	NOUN
ajst-17938	27	17	and	and	CCONJ
ajst-17938	27	18	promote	promote	VERB
ajst-17938	27	19	cell	cell	NOUN
ajst-17938	27	20	apoptosis	apoptosis	NOUN
ajst-17938	27	21	.	.	PUNCT
ajst-17938	28	1	moreover	moreover	ADV
ajst-17938	28	2	,	,	PUNCT
ajst-17938	28	3	these	these	DET
ajst-17938	28	4	compounds	compound	NOUN
ajst-17938	28	5	can	can	AUX
ajst-17938	28	6	also	also	ADV
ajst-17938	28	7	exert	exert	VERB
ajst-17938	28	8	their	their	PRON
ajst-17938	28	9	antitumor	antitumor	PROPN
ajst-17938	28	10	effects	effect	NOUN
ajst-17938	28	11	by	by	ADP
ajst-17938	28	12	inhibiting	inhibit	VERB
ajst-17938	28	13	multiple	multiple	ADJ
ajst-17938	28	14	signaling	signal	VERB
ajst-17938	28	15	pathways	pathway	NOUN
ajst-17938	28	16	in	in	ADP
ajst-17938	28	17	tumor	tumor	NOUN
ajst-17938	28	18	cells	cell	NOUN
ajst-17938	28	19	.	.	PUNCT
ajst-17938	29	1	these	these	DET
ajst-17938	29	2	findings	finding	NOUN
ajst-17938	29	3	provide	provide	VERB
ajst-17938	29	4	strong	strong	ADJ
ajst-17938	29	5	support	support	NOUN
ajst-17938	29	6	for	for	ADP
ajst-17938	29	7	the	the	DET
ajst-17938	29	8	use	use	NOUN
ajst-17938	29	9	of	of	ADP
ajst-17938	29	10	banned	ban	VERB
ajst-17938	29	11	imide	imide	ADJ
ajst-17938	29	12	-	-	PUNCT
ajst-17938	29	13	polyamine	polyamine	NOUN
ajst-17938	29	14	conjugates	conjugate	NOUN
ajst-17938	29	15	in	in	ADP
ajst-17938	29	16	clinical	clinical	ADJ
ajst-17938	29	17	treatment	treatment	NOUN
ajst-17938	29	18	.	.	PUNCT
ajst-17938	30	1	forbidden	forbid	VERB
ajst-17938	30	2	imide	imide	ADJ
ajst-17938	30	3	-	-	PUNCT
ajst-17938	30	4	polyamine	polyamine	NOUN
ajst-17938	30	5	conjugates	conjugate	NOUN
ajst-17938	30	6	have	have	AUX
ajst-17938	30	7	been	be	AUX
ajst-17938	30	8	widely	widely	ADV
ajst-17938	30	9	studied	study	VERB
ajst-17938	30	10	and	and	CCONJ
ajst-17938	30	11	used	use	VERB
ajst-17938	30	12	in	in	ADP
ajst-17938	30	13	the	the	DET
ajst-17938	30	14	treatment	treatment	NOUN
ajst-17938	30	15	of	of	ADP
ajst-17938	30	16	liver	liver	NOUN
ajst-17938	30	17	cancer	cancer	NOUN
ajst-17938	30	18	.	.	PUNCT
ajst-17938	31	1	however	however	ADV
ajst-17938	31	2	,	,	PUNCT
ajst-17938	31	3	the	the	DET
ajst-17938	31	4	clinical	clinical	ADJ
ajst-17938	31	5	application	application	NOUN
ajst-17938	31	6	of	of	ADP
ajst-17938	31	7	forbidden	forbid	VERB
ajst-17938	31	8	imide	imide	ADJ
ajst-17938	31	9	-	-	PUNCT
ajst-17938	31	10	polyamine	polyamine	NOUN
ajst-17938	31	11	conjugates	conjugate	NOUN
ajst-17938	31	12	still	still	ADV
ajst-17938	31	13	faces	face	VERB
ajst-17938	31	14	some	some	DET
ajst-17938	31	15	challenges	challenge	NOUN
ajst-17938	31	16	.	.	PUNCT
ajst-17938	32	1	first	first	ADV
ajst-17938	32	2	,	,	PUNCT
ajst-17938	32	3	the	the	DET
ajst-17938	32	4	toxic	toxic	ADJ
ajst-17938	32	5	side	side	NOUN
ajst-17938	32	6	effects	effect	NOUN
ajst-17938	32	7	of	of	ADP
ajst-17938	32	8	these	these	DET
ajst-17938	32	9	compounds	compound	NOUN
ajst-17938	32	10	are	be	AUX
ajst-17938	32	11	unknown	unknown	ADJ
ajst-17938	32	12	,	,	PUNCT
ajst-17938	32	13	and	and	CCONJ
ajst-17938	32	14	further	further	ADJ
ajst-17938	32	15	studies	study	NOUN
ajst-17938	32	16	are	be	AUX
ajst-17938	32	17	needed	need	VERB
ajst-17938	32	18	to	to	PART
ajst-17938	32	19	evaluate	evaluate	VERB
ajst-17938	32	20	their	their	PRON
ajst-17938	32	21	safety	safety	NOUN
ajst-17938	32	22	and	and	CCONJ
ajst-17938	32	23	tolerability	tolerability	NOUN
ajst-17938	32	24	.	.	PUNCT
ajst-17938	33	1	secondly	secondly	ADV
ajst-17938	33	2	,	,	PUNCT
ajst-17938	33	3	appropriate	appropriate	ADJ
ajst-17938	33	4	administration	administration	NOUN
ajst-17938	33	5	routes	route	NOUN
ajst-17938	33	6	and	and	CCONJ
ajst-17938	33	7	drug	drug	NOUN
ajst-17938	33	8	dose	dose	NOUN
ajst-17938	33	9	also	also	ADV
ajst-17938	33	10	need	need	VERB
ajst-17938	33	11	to	to	PART
ajst-17938	33	12	be	be	AUX
ajst-17938	33	13	further	far	ADV
ajst-17938	33	14	optimized	optimize	VERB
ajst-17938	33	15	.	.	PUNCT
ajst-17938	34	1	finally	finally	ADV
ajst-17938	34	2	,	,	PUNCT
ajst-17938	34	3	the	the	DET
ajst-17938	34	4	design	design	NOUN
ajst-17938	34	5	and	and	CCONJ
ajst-17938	34	6	implementation	implementation	NOUN
ajst-17938	34	7	of	of	ADP
ajst-17938	34	8	clinical	clinical	ADJ
ajst-17938	34	9	trials	trial	NOUN
ajst-17938	34	10	also	also	ADV
ajst-17938	34	11	need	need	VERB
ajst-17938	34	12	to	to	PART
ajst-17938	34	13	take	take	VERB
ajst-17938	34	14	into	into	ADP
ajst-17938	34	15	account	account	NOUN
ajst-17938	34	16	the	the	DET
ajst-17938	34	17	complexity	complexity	NOUN
ajst-17938	34	18	and	and	CCONJ
ajst-17938	34	19	diversity	diversity	NOUN
ajst-17938	34	20	of	of	ADP
ajst-17938	34	21	hcc	hcc	PROPN
ajst-17938	34	22	.	.	PUNCT
ajst-17938	35	1	this	this	DET
ajst-17938	35	2	paper	paper	NOUN
ajst-17938	35	3	aims	aim	VERB
ajst-17938	35	4	to	to	PART
ajst-17938	35	5	review	review	VERB
ajst-17938	35	6	the	the	DET
ajst-17938	35	7	anti	anti	ADJ
ajst-17938	35	8	-	-	ADJ
ajst-17938	35	9	metastasis	metastasis	ADJ
ajst-17938	35	10	drug	drug	NOUN
ajst-17938	35	11	development	development	NOUN
ajst-17938	35	12	of	of	ADP
ajst-17938	35	13	banned	ban	VERB
ajst-17938	35	14	imide	imide	ADJ
ajst-17938	35	15	-	-	PUNCT
ajst-17938	35	16	polyamine	polyamine	NOUN
ajst-17938	35	17	conjugates	conjugate	NOUN
ajst-17938	35	18	and	and	CCONJ
ajst-17938	35	19	its	its	PRON
ajst-17938	35	20	application	application	NOUN
ajst-17938	35	21	in	in	ADP
ajst-17938	35	22	hcc	hcc	PROPN
ajst-17938	35	23	treatment	treatment	NOUN
ajst-17938	35	24	,	,	PUNCT
ajst-17938	35	25	so	so	SCONJ
ajst-17938	35	26	as	as	SCONJ
ajst-17938	35	27	to	to	PART
ajst-17938	35	28	provide	provide	VERB
ajst-17938	35	29	new	new	ADJ
ajst-17938	35	30	ideas	idea	NOUN
ajst-17938	35	31	and	and	CCONJ
ajst-17938	35	32	methods	method	NOUN
ajst-17938	35	33	for	for	ADP
ajst-17938	35	34	hcc	hcc	PROPN
ajst-17938	35	35	treatment	treatment	NOUN
ajst-17938	35	36	.	.	PUNCT
ajst-17938	36	1	by	by	ADP
ajst-17938	36	2	systematically	systematically	ADV
ajst-17938	36	3	analyzing	analyze	VERB
ajst-17938	36	4	the	the	DET
ajst-17938	36	5	pharmacological	pharmacological	ADJ
ajst-17938	36	6	properties	property	NOUN
ajst-17938	36	7	,	,	PUNCT
ajst-17938	36	8	action	action	NOUN
ajst-17938	36	9	mechanism	mechanism	NOUN
ajst-17938	36	10	and	and	CCONJ
ajst-17938	36	11	clinical	clinical	ADJ
ajst-17938	36	12	application	application	NOUN
ajst-17938	36	13	of	of	ADP
ajst-17938	36	14	banned	ban	VERB
ajst-17938	36	15	imide	imide	ADJ
ajst-17938	36	16	-	-	PUNCT
ajst-17938	36	17	polyamine	polyamine	NOUN
ajst-17938	36	18	conjugate	conjugate	NOUN
ajst-17938	36	19	,	,	PUNCT
ajst-17938	36	20	we	we	PRON
ajst-17938	36	21	explore	explore	VERB
ajst-17938	36	22	its	its	PRON
ajst-17938	36	23	potential	potential	ADJ
ajst-17938	36	24	advantages	advantage	NOUN
ajst-17938	36	25	and	and	CCONJ
ajst-17938	36	26	application	application	NOUN
ajst-17938	36	27	prospects	prospect	NOUN
ajst-17938	36	28	in	in	ADP
ajst-17938	36	29	the	the	DET
ajst-17938	36	30	treatment	treatment	NOUN
ajst-17938	36	31	of	of	ADP
ajst-17938	36	32	hcc	hcc	PROPN
ajst-17938	36	33	.	.	PUNCT
ajst-17938	37	1	this	this	DET
ajst-17938	37	2	study	study	NOUN
ajst-17938	37	3	has	have	VERB
ajst-17938	37	4	important	important	ADJ
ajst-17938	37	5	clinical	clinical	ADJ
ajst-17938	37	6	significance	significance	NOUN
ajst-17938	37	7	and	and	CCONJ
ajst-17938	37	8	is	be	AUX
ajst-17938	37	9	expected	expect	VERB
ajst-17938	37	10	to	to	PART
ajst-17938	37	11	provide	provide	VERB
ajst-17938	37	12	new	new	ADJ
ajst-17938	37	13	effective	effective	ADJ
ajst-17938	37	14	drug	drug	NOUN
ajst-17938	37	15	options	option	NOUN
ajst-17938	37	16	for	for	ADP
ajst-17938	37	17	the	the	DET
ajst-17938	37	18	treatment	treatment	NOUN
ajst-17938	37	19	of	of	ADP
ajst-17938	37	20	hcc	hcc	PROPN
ajst-17938	37	21	and	and	CCONJ
ajst-17938	37	22	improve	improve	VERB
ajst-17938	37	23	the	the	DET
ajst-17938	37	24	survival	survival	NOUN
ajst-17938	37	25	rate	rate	NOUN
ajst-17938	37	26	and	and	CCONJ
ajst-17938	37	27	quality	quality	NOUN
ajst-17938	37	28	of	of	ADP
ajst-17938	37	29	life	life	NOUN
ajst-17938	37	30	of	of	ADP
ajst-17938	37	31	patients	patient	NOUN
ajst-17938	37	32	.	.	PUNCT
ajst-17938	38	1	2	2	X
ajst-17938	38	2	.	.	X
ajst-17938	38	3	characteristics	characteristic	NOUN
ajst-17938	38	4	of	of	ADP
ajst-17938	38	5	banned	ban	VERB
ajst-17938	38	6	imidepolyamine	imidepolyamine	ADJ
ajst-17938	38	7	conjugates	conjugate	NOUN
ajst-17938	38	8	with	with	ADP
ajst-17938	38	9	antitransfer	antitransfer	NOUN
ajst-17938	38	10	mechanisms	mechanism	NOUN
ajst-17938	38	11	liver	liver	NOUN
ajst-17938	38	12	cancer	cancer	NOUN
ajst-17938	38	13	is	be	AUX
ajst-17938	38	14	one	one	NUM
ajst-17938	38	15	of	of	ADP
ajst-17938	38	16	the	the	DET
ajst-17938	38	17	most	most	ADV
ajst-17938	38	18	common	common	ADJ
ajst-17938	38	19	malignant	malignant	ADJ
ajst-17938	38	20	tumors	tumor	NOUN
ajst-17938	38	21	in	in	ADP
ajst-17938	38	22	the	the	DET
ajst-17938	38	23	world	world	NOUN
ajst-17938	38	24	,	,	PUNCT
ajst-17938	38	25	and	and	CCONJ
ajst-17938	38	26	its	its	PRON
ajst-17938	38	27	mortality	mortality	NOUN
ajst-17938	38	28	is	be	AUX
ajst-17938	38	29	extremely	extremely	ADV
ajst-17938	38	30	high	high	ADJ
ajst-17938	38	31	.	.	PUNCT
ajst-17938	39	1	in	in	ADP
ajst-17938	39	2	china	china	PROPN
ajst-17938	39	3	,	,	PUNCT
ajst-17938	39	4	the	the	DET
ajst-17938	39	5	incidence	incidence	NOUN
ajst-17938	39	6	and	and	CCONJ
ajst-17938	39	7	mortality	mortality	NOUN
ajst-17938	39	8	of	of	ADP
ajst-17938	39	9	liver	liver	NOUN
ajst-17938	39	10	cancer	cancer	NOUN
ajst-17938	39	11	rank	rank	NOUN
ajst-17938	39	12	first	first	ADV
ajst-17938	39	13	among	among	ADP
ajst-17938	39	14	malignant	malignant	ADJ
ajst-17938	39	15	tumors	tumor	NOUN
ajst-17938	39	16	.	.	PUNCT
ajst-17938	40	1	metastasis	metastasis	NOUN
ajst-17938	40	2	of	of	ADP
ajst-17938	40	3	liver	liver	NOUN
ajst-17938	40	4	cancer	cancer	NOUN
ajst-17938	40	5	is	be	AUX
ajst-17938	40	6	one	one	NUM
ajst-17938	40	7	of	of	ADP
ajst-17938	40	8	the	the	DET
ajst-17938	40	9	262	262	NUM
ajst-17938	40	10	main	main	ADJ
ajst-17938	40	11	causes	cause	NOUN
ajst-17938	40	12	of	of	ADP
ajst-17938	40	13	death	death	NOUN
ajst-17938	40	14	of	of	ADP
ajst-17938	40	15	patients	patient	NOUN
ajst-17938	40	16	.	.	PUNCT
ajst-17938	41	1	therefore	therefore	ADV
ajst-17938	41	2	,	,	PUNCT
ajst-17938	41	3	the	the	DET
ajst-17938	41	4	development	development	NOUN
ajst-17938	41	5	of	of	ADP
ajst-17938	41	6	effective	effective	ADJ
ajst-17938	41	7	anti	anti	ADJ
ajst-17938	41	8	metastatic	metastatic	ADJ
ajst-17938	41	9	drugs	drug	NOUN
ajst-17938	41	10	for	for	ADP
ajst-17938	41	11	liver	liver	NOUN
ajst-17938	41	12	cancer	cancer	NOUN
ajst-17938	41	13	is	be	AUX
ajst-17938	41	14	of	of	ADP
ajst-17938	41	15	great	great	ADJ
ajst-17938	41	16	significance	significance	NOUN
ajst-17938	41	17	to	to	PART
ajst-17938	41	18	improve	improve	VERB
ajst-17938	41	19	the	the	DET
ajst-17938	41	20	survival	survival	NOUN
ajst-17938	41	21	rate	rate	NOUN
ajst-17938	41	22	and	and	CCONJ
ajst-17938	41	23	prognosis	prognosis	NOUN
ajst-17938	41	24	of	of	ADP
ajst-17938	41	25	patients	patient	NOUN
ajst-17938	41	26	.	.	PUNCT
ajst-17938	42	1	at	at	ADP
ajst-17938	42	2	present	present	ADJ
ajst-17938	42	3	,	,	PUNCT
ajst-17938	42	4	the	the	DET
ajst-17938	42	5	treatment	treatment	NOUN
ajst-17938	42	6	of	of	ADP
ajst-17938	42	7	liver	liver	NOUN
ajst-17938	42	8	cancer	cancer	NOUN
ajst-17938	42	9	mainly	mainly	ADV
ajst-17938	42	10	includes	include	VERB
ajst-17938	42	11	surgical	surgical	ADJ
ajst-17938	42	12	resection	resection	NOUN
ajst-17938	42	13	,	,	PUNCT
ajst-17938	42	14	chemotherapy	chemotherapy	NOUN
ajst-17938	42	15	,	,	PUNCT
ajst-17938	42	16	radiotherapy	radiotherapy	NOUN
ajst-17938	42	17	and	and	CCONJ
ajst-17938	42	18	targeted	target	VERB
ajst-17938	42	19	therapy	therapy	NOUN
ajst-17938	42	20	.	.	PUNCT
ajst-17938	43	1	however	however	ADV
ajst-17938	43	2	,	,	PUNCT
ajst-17938	43	3	these	these	DET
ajst-17938	43	4	treatments	treatment	NOUN
ajst-17938	43	5	have	have	AUX
ajst-17938	43	6	limited	limit	VERB
ajst-17938	43	7	curative	curative	ADJ
ajst-17938	43	8	effect	effect	NOUN
ajst-17938	43	9	on	on	ADP
ajst-17938	43	10	liver	liver	NOUN
ajst-17938	43	11	cancer	cancer	NOUN
ajst-17938	43	12	metastasis	metastasis	NOUN
ajst-17938	43	13	,	,	PUNCT
ajst-17938	43	14	and	and	CCONJ
ajst-17938	43	15	have	have	VERB
ajst-17938	43	16	large	large	ADJ
ajst-17938	43	17	side	side	NOUN
ajst-17938	43	18	effects	effect	NOUN
ajst-17938	43	19	.	.	PUNCT
ajst-17938	44	1	therefore	therefore	ADV
ajst-17938	44	2	,	,	PUNCT
ajst-17938	44	3	searching	search	VERB
ajst-17938	44	4	for	for	ADP
ajst-17938	44	5	new	new	ADJ
ajst-17938	44	6	anti	anti	ADJ
ajst-17938	44	7	metastatic	metastatic	ADJ
ajst-17938	44	8	drug	drug	NOUN
ajst-17938	44	9	targets	target	NOUN
ajst-17938	44	10	and	and	CCONJ
ajst-17938	44	11	developing	develop	VERB
ajst-17938	44	12	new	new	ADJ
ajst-17938	44	13	anti	anti	ADJ
ajst-17938	44	14	metastatic	metastatic	ADJ
ajst-17938	44	15	drugs	drug	NOUN
ajst-17938	44	16	have	have	AUX
ajst-17938	44	17	become	become	VERB
ajst-17938	44	18	a	a	DET
ajst-17938	44	19	hot	hot	ADJ
ajst-17938	44	20	spot	spot	NOUN
ajst-17938	44	21	in	in	ADP
ajst-17938	44	22	the	the	DET
ajst-17938	44	23	field	field	NOUN
ajst-17938	44	24	of	of	ADP
ajst-17938	44	25	liver	liver	NOUN
ajst-17938	44	26	cancer	cancer	NOUN
ajst-17938	44	27	research	research	NOUN
ajst-17938	44	28	.	.	PUNCT
ajst-17938	45	1	in	in	ADP
ajst-17938	45	2	recent	recent	ADJ
ajst-17938	45	3	years	year	NOUN
ajst-17938	45	4	,	,	PUNCT
ajst-17938	45	5	imides	imide	VERB
ajst-17938	45	6	polyamine	polyamine	NOUN
ajst-17938	45	7	conjugates	conjugate	NOUN
ajst-17938	45	8	have	have	AUX
ajst-17938	45	9	attracted	attract	VERB
ajst-17938	45	10	extensive	extensive	ADJ
ajst-17938	45	11	attention	attention	NOUN
ajst-17938	45	12	as	as	ADP
ajst-17938	45	13	a	a	DET
ajst-17938	45	14	new	new	ADJ
ajst-17938	45	15	type	type	NOUN
ajst-17938	45	16	of	of	ADP
ajst-17938	45	17	antitumor	antitumor	PROPN
ajst-17938	45	18	drug	drug	NOUN
ajst-17938	45	19	.	.	PUNCT
ajst-17938	46	1	imides	imide	VERB
ajst-17938	46	2	polyamine	polyamine	NOUN
ajst-17938	46	3	conjugates	conjugate	NOUN
ajst-17938	46	4	have	have	VERB
ajst-17938	46	5	unique	unique	ADJ
ajst-17938	46	6	molecular	molecular	ADJ
ajst-17938	46	7	structure	structure	NOUN
ajst-17938	46	8	and	and	CCONJ
ajst-17938	46	9	good	good	ADJ
ajst-17938	46	10	biocompatibility	biocompatibility	NOUN
ajst-17938	46	11	,	,	PUNCT
ajst-17938	46	12	which	which	PRON
ajst-17938	46	13	can	can	AUX
ajst-17938	46	14	inhibit	inhibit	VERB
ajst-17938	46	15	the	the	DET
ajst-17938	46	16	growth	growth	NOUN
ajst-17938	46	17	and	and	CCONJ
ajst-17938	46	18	metastasis	metastasis	NOUN
ajst-17938	46	19	of	of	ADP
ajst-17938	46	20	tumor	tumor	NOUN
ajst-17938	46	21	cells	cell	NOUN
ajst-17938	46	22	through	through	ADP
ajst-17938	46	23	a	a	DET
ajst-17938	46	24	variety	variety	NOUN
ajst-17938	46	25	of	of	ADP
ajst-17938	46	26	mechanisms	mechanism	NOUN
ajst-17938	46	27	.	.	PUNCT
ajst-17938	47	1	this	this	DET
ajst-17938	47	2	study	study	NOUN
ajst-17938	47	3	aimed	aim	VERB
ajst-17938	47	4	to	to	PART
ajst-17938	47	5	explore	explore	VERB
ajst-17938	47	6	the	the	DET
ajst-17938	47	7	characteristics	characteristic	NOUN
ajst-17938	47	8	and	and	CCONJ
ajst-17938	47	9	anti	anti	ADJ
ajst-17938	47	10	metastatic	metastatic	ADJ
ajst-17938	47	11	mechanism	mechanism	NOUN
ajst-17938	47	12	of	of	ADP
ajst-17938	47	13	imides	imide	NOUN
ajst-17938	47	14	polyamine	polyamine	NOUN
ajst-17938	47	15	conjugates	conjugate	NOUN
ajst-17938	47	16	,	,	PUNCT
ajst-17938	47	17	in	in	ADP
ajst-17938	47	18	order	order	NOUN
ajst-17938	47	19	to	to	PART
ajst-17938	47	20	provide	provide	VERB
ajst-17938	47	21	a	a	DET
ajst-17938	47	22	new	new	ADJ
ajst-17938	47	23	strategy	strategy	NOUN
ajst-17938	47	24	for	for	ADP
ajst-17938	47	25	the	the	DET
ajst-17938	47	26	prevention	prevention	NOUN
ajst-17938	47	27	and	and	CCONJ
ajst-17938	47	28	treatment	treatment	NOUN
ajst-17938	47	29	of	of	ADP
ajst-17938	47	30	liver	liver	NOUN
ajst-17938	47	31	cancer	cancer	NOUN
ajst-17938	47	32	.	.	PUNCT
ajst-17938	48	1	the	the	DET
ajst-17938	48	2	imido	imido	ADJ
ajst-17938	48	3	polyamine	polyamine	NOUN
ajst-17938	48	4	conjugate	conjugate	NOUN
ajst-17938	48	5	is	be	AUX
ajst-17938	48	6	composed	compose	VERB
ajst-17938	48	7	of	of	ADP
ajst-17938	48	8	imides	imide	NOUN
ajst-17938	48	9	and	and	CCONJ
ajst-17938	48	10	polyamines	polyamine	NOUN
ajst-17938	48	11	.	.	PUNCT
ajst-17938	49	1	the	the	DET
ajst-17938	49	2	imide	imide	ADJ
ajst-17938	49	3	moiety	moiety	NOUN
ajst-17938	49	4	has	have	VERB
ajst-17938	49	5	good	good	ADJ
ajst-17938	49	6	water	water	NOUN
ajst-17938	49	7	solubility	solubility	NOUN
ajst-17938	49	8	and	and	CCONJ
ajst-17938	49	9	biodegradability	biodegradability	NOUN
ajst-17938	49	10	,	,	PUNCT
ajst-17938	49	11	which	which	PRON
ajst-17938	49	12	can	can	AUX
ajst-17938	49	13	effectively	effectively	ADV
ajst-17938	49	14	enter	enter	VERB
ajst-17938	49	15	the	the	DET
ajst-17938	49	16	cell	cell	NOUN
ajst-17938	49	17	interior	interior	NOUN
ajst-17938	49	18	and	and	CCONJ
ajst-17938	49	19	play	play	VERB
ajst-17938	49	20	an	an	DET
ajst-17938	49	21	anti	anti	ADJ
ajst-17938	49	22	-	-	ADJ
ajst-17938	49	23	tumor	tumor	ADJ
ajst-17938	49	24	role	role	NOUN
ajst-17938	49	25	.	.	PUNCT
ajst-17938	50	1	polyamine	polyamine	NOUN
ajst-17938	50	2	moiety	moiety	PROPN
ajst-17938	50	3	has	have	VERB
ajst-17938	50	4	biological	biological	ADJ
ajst-17938	50	5	activities	activity	NOUN
ajst-17938	50	6	such	such	ADJ
ajst-17938	50	7	as	as	ADP
ajst-17938	50	8	regulating	regulate	VERB
ajst-17938	50	9	intracellular	intracellular	ADJ
ajst-17938	50	10	ph	ph	NOUN
ajst-17938	50	11	and	and	CCONJ
ajst-17938	50	12	affecting	affect	VERB
ajst-17938	50	13	cell	cell	NOUN
ajst-17938	50	14	signaling	signal	VERB
ajst-17938	50	15	,	,	PUNCT
ajst-17938	50	16	thereby	thereby	ADV
ajst-17938	50	17	inhibiting	inhibit	VERB
ajst-17938	50	18	the	the	DET
ajst-17938	50	19	growth	growth	NOUN
ajst-17938	50	20	and	and	CCONJ
ajst-17938	50	21	metastasis	metastasis	NOUN
ajst-17938	50	22	of	of	ADP
ajst-17938	50	23	tumor	tumor	NOUN
ajst-17938	50	24	cells[1	cells[1	NOUN
ajst-17938	50	25	]	]	PUNCT
ajst-17938	50	26	.	.	PUNCT
ajst-17938	51	1	the	the	DET
ajst-17938	51	2	anti	anti	ADJ
ajst-17938	51	3	-	-	ADJ
ajst-17938	51	4	transfer	transfer	ADJ
ajst-17938	51	5	mechanism	mechanism	NOUN
ajst-17938	51	6	of	of	ADP
ajst-17938	51	7	forbidden	forbid	VERB
ajst-17938	51	8	imidepolyamine	imidepolyamine	ADJ
ajst-17938	51	9	conjugates	conjugate	NOUN
ajst-17938	51	10	mainly	mainly	ADV
ajst-17938	51	11	includes	include	VERB
ajst-17938	51	12	the	the	DET
ajst-17938	51	13	following	follow	VERB
ajst-17938	51	14	aspects	aspect	NOUN
ajst-17938	51	15	:	:	PUNCT
ajst-17938	51	16	1	1	X
ajst-17938	51	17	.	.	X
ajst-17938	51	18	inhibit	inhibit	VERB
ajst-17938	51	19	the	the	DET
ajst-17938	51	20	migration	migration	NOUN
ajst-17938	51	21	and	and	CCONJ
ajst-17938	51	22	invasion	invasion	NOUN
ajst-17938	51	23	ability	ability	NOUN
ajst-17938	51	24	of	of	ADP
ajst-17938	51	25	tumor	tumor	NOUN
ajst-17938	51	26	cells	cell	NOUN
ajst-17938	51	27	:	:	PUNCT
ajst-17938	51	28	studies	study	NOUN
ajst-17938	51	29	have	have	AUX
ajst-17938	51	30	found	find	VERB
ajst-17938	51	31	that	that	SCONJ
ajst-17938	51	32	the	the	DET
ajst-17938	51	33	forbidden	forbid	VERB
ajst-17938	51	34	imide	imide	ADJ
ajst-17938	51	35	-	-	PUNCT
ajst-17938	51	36	polyamine	polyamine	NOUN
ajst-17938	51	37	conjugates	conjugate	NOUN
ajst-17938	51	38	can	can	AUX
ajst-17938	51	39	inhibit	inhibit	VERB
ajst-17938	51	40	the	the	DET
ajst-17938	51	41	migration	migration	NOUN
ajst-17938	51	42	and	and	CCONJ
ajst-17938	51	43	invasion	invasion	NOUN
ajst-17938	51	44	ability	ability	NOUN
ajst-17938	51	45	of	of	ADP
ajst-17938	51	46	tumor	tumor	NOUN
ajst-17938	51	47	cells	cell	NOUN
ajst-17938	51	48	by	by	ADP
ajst-17938	51	49	interfering	interfere	VERB
ajst-17938	51	50	with	with	ADP
ajst-17938	51	51	intracellular	intracellular	ADJ
ajst-17938	51	52	signaling	signal	VERB
ajst-17938	51	53	pathways	pathway	NOUN
ajst-17938	51	54	and	and	CCONJ
ajst-17938	51	55	affecting	affect	VERB
ajst-17938	51	56	cytoskeletal	cytoskeletal	ADJ
ajst-17938	51	57	reorganization	reorganization	NOUN
ajst-17938	51	58	.	.	PUNCT
ajst-17938	52	1	for	for	ADP
ajst-17938	52	2	example	example	NOUN
ajst-17938	52	3	,	,	PUNCT
ajst-17938	52	4	they	they	PRON
ajst-17938	52	5	are	be	AUX
ajst-17938	52	6	able	able	ADJ
ajst-17938	52	7	to	to	PART
ajst-17938	52	8	inhibit	inhibit	VERB
ajst-17938	52	9	the	the	DET
ajst-17938	52	10	expression	expression	NOUN
ajst-17938	52	11	and	and	CCONJ
ajst-17938	52	12	activity	activity	NOUN
ajst-17938	52	13	of	of	ADP
ajst-17938	52	14	proteins	protein	NOUN
ajst-17938	52	15	associated	associate	VERB
ajst-17938	52	16	with	with	ADP
ajst-17938	52	17	cell	cell	NOUN
ajst-17938	52	18	motility	motility	NOUN
ajst-17938	52	19	and	and	CCONJ
ajst-17938	52	20	invasion	invasion	NOUN
ajst-17938	52	21	in	in	ADP
ajst-17938	52	22	tumor	tumor	NOUN
ajst-17938	52	23	cells	cell	NOUN
ajst-17938	52	24	,	,	PUNCT
ajst-17938	52	25	thereby	thereby	ADV
ajst-17938	52	26	reducing	reduce	VERB
ajst-17938	52	27	the	the	DET
ajst-17938	52	28	metastatic	metastatic	ADJ
ajst-17938	52	29	capacity	capacity	NOUN
ajst-17938	52	30	of	of	ADP
ajst-17938	52	31	tumor	tumor	NOUN
ajst-17938	52	32	cells	cell	NOUN
ajst-17938	52	33	.	.	PUNCT
ajst-17938	53	1	2	2	X
ajst-17938	53	2	.	.	X
ajst-17938	53	3	induce	induce	VERB
ajst-17938	53	4	apoptosis	apoptosis	NOUN
ajst-17938	53	5	of	of	ADP
ajst-17938	53	6	tumor	tumor	NOUN
ajst-17938	53	7	cells	cell	NOUN
ajst-17938	53	8	:	:	PUNCT
ajst-17938	53	9	forbidden	forbid	VERB
ajst-17938	53	10	imidepolyamine	imidepolyamine	ADJ
ajst-17938	53	11	conjugates	conjugate	NOUN
ajst-17938	53	12	can	can	AUX
ajst-17938	53	13	induce	induce	VERB
ajst-17938	53	14	apoptosis	apoptosis	NOUN
ajst-17938	53	15	of	of	ADP
ajst-17938	53	16	tumor	tumor	NOUN
ajst-17938	53	17	cells	cell	NOUN
ajst-17938	53	18	,	,	PUNCT
ajst-17938	53	19	which	which	PRON
ajst-17938	53	20	is	be	AUX
ajst-17938	53	21	one	one	NUM
ajst-17938	53	22	of	of	ADP
ajst-17938	53	23	the	the	DET
ajst-17938	53	24	important	important	ADJ
ajst-17938	53	25	mechanisms	mechanism	NOUN
ajst-17938	53	26	of	of	ADP
ajst-17938	53	27	their	their	PRON
ajst-17938	53	28	antimetastasis	antimetastasi	NOUN
ajst-17938	53	29	.	.	PUNCT
ajst-17938	54	1	they	they	PRON
ajst-17938	54	2	are	be	AUX
ajst-17938	54	3	able	able	ADJ
ajst-17938	54	4	to	to	PART
ajst-17938	54	5	induce	induce	VERB
ajst-17938	54	6	apoptosis	apoptosis	NOUN
ajst-17938	54	7	in	in	ADP
ajst-17938	54	8	tumor	tumor	NOUN
ajst-17938	54	9	cells	cell	NOUN
ajst-17938	54	10	by	by	ADP
ajst-17938	54	11	affecting	affect	VERB
ajst-17938	54	12	intracellular	intracellular	ADJ
ajst-17938	54	13	signaling	signal	VERB
ajst-17938	54	14	pathways	pathway	NOUN
ajst-17938	54	15	,	,	PUNCT
ajst-17938	54	16	such	such	ADJ
ajst-17938	54	17	as	as	ADP
ajst-17938	54	18	the	the	DET
ajst-17938	54	19	mitochondrial	mitochondrial	ADJ
ajst-17938	54	20	pathway	pathway	NOUN
ajst-17938	54	21	and	and	CCONJ
ajst-17938	54	22	the	the	DET
ajst-17938	54	23	death	death	NOUN
ajst-17938	54	24	receptor	receptor	NOUN
ajst-17938	54	25	pathway	pathway	NOUN
ajst-17938	54	26	.	.	PUNCT
ajst-17938	55	1	3	3	X
ajst-17938	55	2	.	.	X
ajst-17938	55	3	inhibit	inhibit	VERB
ajst-17938	55	4	the	the	DET
ajst-17938	55	5	proliferation	proliferation	NOUN
ajst-17938	55	6	of	of	ADP
ajst-17938	55	7	tumor	tumor	NOUN
ajst-17938	55	8	cells	cell	NOUN
ajst-17938	55	9	:	:	PUNCT
ajst-17938	55	10	the	the	DET
ajst-17938	55	11	forbidden	forbid	VERB
ajst-17938	55	12	imide	imide	ADJ
ajst-17938	55	13	-	-	PUNCT
ajst-17938	55	14	polyamine	polyamine	NOUN
ajst-17938	55	15	conjugate	conjugate	NOUN
ajst-17938	55	16	can	can	AUX
ajst-17938	55	17	inhibit	inhibit	VERB
ajst-17938	55	18	the	the	DET
ajst-17938	55	19	proliferation	proliferation	NOUN
ajst-17938	55	20	of	of	ADP
ajst-17938	55	21	tumor	tumor	NOUN
ajst-17938	55	22	cells	cell	NOUN
ajst-17938	55	23	,	,	PUNCT
ajst-17938	55	24	thus	thus	ADV
ajst-17938	55	25	inhibiting	inhibit	VERB
ajst-17938	55	26	the	the	DET
ajst-17938	55	27	development	development	NOUN
ajst-17938	55	28	of	of	ADP
ajst-17938	55	29	liver	liver	NOUN
ajst-17938	55	30	cancer	cancer	NOUN
ajst-17938	55	31	.	.	PUNCT
ajst-17938	56	1	they	they	PRON
ajst-17938	56	2	are	be	AUX
ajst-17938	56	3	able	able	ADJ
ajst-17938	56	4	to	to	PART
ajst-17938	56	5	stop	stop	VERB
ajst-17938	56	6	the	the	DET
ajst-17938	56	7	proliferation	proliferation	NOUN
ajst-17938	56	8	of	of	ADP
ajst-17938	56	9	tumor	tumor	NOUN
ajst-17938	56	10	cells	cell	NOUN
ajst-17938	56	11	by	by	ADP
ajst-17938	56	12	affecting	affect	VERB
ajst-17938	56	13	the	the	DET
ajst-17938	56	14	expression	expression	NOUN
ajst-17938	56	15	and	and	CCONJ
ajst-17938	56	16	activity	activity	NOUN
ajst-17938	56	17	of	of	ADP
ajst-17938	56	18	cell	cell	NOUN
ajst-17938	56	19	-	-	PUNCT
ajst-17938	56	20	cycle	cycle	NOUN
ajst-17938	56	21	-	-	PUNCT
ajst-17938	56	22	related	relate	VERB
ajst-17938	56	23	proteins	protein	NOUN
ajst-17938	56	24	.	.	PUNCT
ajst-17938	57	1	4	4	X
ajst-17938	57	2	.	.	X
ajst-17938	57	3	promote	promote	VERB
ajst-17938	57	4	autophagy	autophagy	ADJ
ajst-17938	57	5	and	and	CCONJ
ajst-17938	57	6	cell	cell	NOUN
ajst-17938	57	7	cycle	cycle	NOUN
ajst-17938	57	8	arrest	arrest	NOUN
ajst-17938	57	9	of	of	ADP
ajst-17938	57	10	tumor	tumor	NOUN
ajst-17938	57	11	cells	cell	NOUN
ajst-17938	57	12	:	:	PUNCT
ajst-17938	57	13	in	in	ADP
ajst-17938	57	14	addition	addition	NOUN
ajst-17938	57	15	to	to	ADP
ajst-17938	57	16	inducing	induce	VERB
ajst-17938	57	17	apoptosis	apoptosis	NOUN
ajst-17938	57	18	and	and	CCONJ
ajst-17938	57	19	inhibiting	inhibit	VERB
ajst-17938	57	20	proliferation	proliferation	NOUN
ajst-17938	57	21	,	,	PUNCT
ajst-17938	57	22	the	the	DET
ajst-17938	57	23	forbidden	forbid	VERB
ajst-17938	57	24	imide	imide	ADJ
ajst-17938	57	25	-	-	PUNCT
ajst-17938	57	26	polyamine	polyamine	NOUN
ajst-17938	57	27	conjugate	conjugate	NOUN
ajst-17938	57	28	can	can	AUX
ajst-17938	57	29	also	also	ADV
ajst-17938	57	30	promote	promote	VERB
ajst-17938	57	31	autophagy	autophagy	ADJ
ajst-17938	57	32	and	and	CCONJ
ajst-17938	57	33	cell	cell	NOUN
ajst-17938	57	34	cycle	cycle	NOUN
ajst-17938	57	35	arrest	arrest	NOUN
ajst-17938	57	36	of	of	ADP
ajst-17938	57	37	tumor	tumor	NOUN
ajst-17938	57	38	cells	cell	NOUN
ajst-17938	57	39	.	.	PUNCT
ajst-17938	58	1	autophagy	autophagy	NOUN
ajst-17938	58	2	is	be	AUX
ajst-17938	58	3	a	a	DET
ajst-17938	58	4	degradation	degradation	NOUN
ajst-17938	58	5	and	and	CCONJ
ajst-17938	58	6	recycling	recycling	NOUN
ajst-17938	58	7	mechanism	mechanism	NOUN
ajst-17938	58	8	inside	inside	ADP
ajst-17938	58	9	the	the	DET
ajst-17938	58	10	cell	cell	NOUN
ajst-17938	58	11	that	that	PRON
ajst-17938	58	12	is	be	AUX
ajst-17938	58	13	capable	capable	ADJ
ajst-17938	58	14	of	of	ADP
ajst-17938	58	15	removing	remove	VERB
ajst-17938	58	16	damaged	damage	VERB
ajst-17938	58	17	organelles	organelle	NOUN
ajst-17938	58	18	and	and	CCONJ
ajst-17938	58	19	proteins	protein	NOUN
ajst-17938	58	20	.	.	PUNCT
ajst-17938	59	1	cell	cell	NOUN
ajst-17938	59	2	cycle	cycle	NOUN
ajst-17938	59	3	arrest	arrest	NOUN
ajst-17938	59	4	is	be	AUX
ajst-17938	59	5	the	the	DET
ajst-17938	59	6	role	role	NOUN
ajst-17938	59	7	of	of	ADP
ajst-17938	59	8	cell	cell	NOUN
ajst-17938	59	9	cycle	cycle	NOUN
ajst-17938	59	10	regulatory	regulatory	ADJ
ajst-17938	59	11	proteins	protein	NOUN
ajst-17938	59	12	that	that	PRON
ajst-17938	59	13	prevent	prevent	VERB
ajst-17938	59	14	the	the	DET
ajst-17938	59	15	cycle	cycle	NOUN
ajst-17938	59	16	progression	progression	NOUN
ajst-17938	59	17	of	of	ADP
ajst-17938	59	18	tumor	tumor	NOUN
ajst-17938	59	19	cells	cell	NOUN
ajst-17938	59	20	.	.	PUNCT
ajst-17938	60	1	5	5	X
ajst-17938	60	2	.	.	X
ajst-17938	60	3	impact	impact	NOUN
ajst-17938	60	4	on	on	ADP
ajst-17938	60	5	tumor	tumor	NOUN
ajst-17938	60	6	angiogenesis	angiogenesis	NOUN
ajst-17938	60	7	:	:	PUNCT
ajst-17938	60	8	tumor	tumor	NOUN
ajst-17938	60	9	growth	growth	NOUN
ajst-17938	60	10	and	and	CCONJ
ajst-17938	60	11	metastasis	metastasis	PRON
ajst-17938	60	12	depend	depend	VERB
ajst-17938	60	13	on	on	ADP
ajst-17938	60	14	the	the	DET
ajst-17938	60	15	generation	generation	NOUN
ajst-17938	60	16	of	of	ADP
ajst-17938	60	17	tumor	tumor	NOUN
ajst-17938	60	18	blood	blood	NOUN
ajst-17938	60	19	vessels	vessel	NOUN
ajst-17938	60	20	.	.	PUNCT
ajst-17938	61	1	therefore	therefore	ADV
ajst-17938	61	2	,	,	PUNCT
ajst-17938	61	3	the	the	DET
ajst-17938	61	4	inhibition	inhibition	NOUN
ajst-17938	61	5	of	of	ADP
ajst-17938	61	6	tumor	tumor	NOUN
ajst-17938	61	7	angiogenesis	angiogenesis	NOUN
ajst-17938	61	8	is	be	AUX
ajst-17938	61	9	one	one	NUM
ajst-17938	61	10	of	of	ADP
ajst-17938	61	11	the	the	DET
ajst-17938	61	12	important	important	ADJ
ajst-17938	61	13	strategies	strategy	NOUN
ajst-17938	61	14	for	for	ADP
ajst-17938	61	15	anti	anti	ADJ
ajst-17938	61	16	-	-	NOUN
ajst-17938	61	17	metastasis	metastasis	NOUN
ajst-17938	61	18	.	.	PUNCT
ajst-17938	62	1	it	it	PRON
ajst-17938	62	2	was	be	AUX
ajst-17938	62	3	found	find	VERB
ajst-17938	62	4	that	that	SCONJ
ajst-17938	62	5	the	the	DET
ajst-17938	62	6	forbidden	forbid	VERB
ajst-17938	62	7	imide	imide	ADJ
ajst-17938	62	8	-	-	PUNCT
ajst-17938	62	9	polyamine	polyamine	NOUN
ajst-17938	62	10	conjugate	conjugate	NOUN
ajst-17938	62	11	was	be	AUX
ajst-17938	62	12	able	able	ADJ
ajst-17938	62	13	to	to	PART
ajst-17938	62	14	inhibit	inhibit	VERB
ajst-17938	62	15	the	the	DET
ajst-17938	62	16	growth	growth	NOUN
ajst-17938	62	17	and	and	CCONJ
ajst-17938	62	18	angiogenesis	angiogenesis	NOUN
ajst-17938	62	19	of	of	ADP
ajst-17938	62	20	tumor	tumor	NOUN
ajst-17938	62	21	blood	blood	NOUN
ajst-17938	62	22	vessels	vessel	NOUN
ajst-17938	62	23	,	,	PUNCT
ajst-17938	62	24	thereby	thereby	ADV
ajst-17938	62	25	inhibiting	inhibit	VERB
ajst-17938	62	26	hcc	hcc	NOUN
ajst-17938	62	27	metastasis	metastasis	NOUN
ajst-17938	62	28	.	.	PUNCT
ajst-17938	63	1	in	in	ADP
ajst-17938	63	2	conclusion	conclusion	NOUN
ajst-17938	63	3	,	,	PUNCT
ajst-17938	63	4	the	the	DET
ajst-17938	63	5	forbidden	forbid	VERB
ajst-17938	63	6	imide	imide	ADJ
ajst-17938	63	7	-	-	PUNCT
ajst-17938	63	8	polyamine	polyamine	NOUN
ajst-17938	63	9	conjugate	conjugate	NOUN
ajst-17938	63	10	,	,	PUNCT
ajst-17938	63	11	as	as	ADP
ajst-17938	63	12	a	a	DET
ajst-17938	63	13	new	new	ADJ
ajst-17938	63	14	anti	anti	ADJ
ajst-17938	63	15	-	-	ADJ
ajst-17938	63	16	tumor	tumor	ADJ
ajst-17938	63	17	drug	drug	NOUN
ajst-17938	63	18	,	,	PUNCT
ajst-17938	63	19	can	can	AUX
ajst-17938	63	20	inhibit	inhibit	VERB
ajst-17938	63	21	the	the	DET
ajst-17938	63	22	migration	migration	NOUN
ajst-17938	63	23	and	and	CCONJ
ajst-17938	63	24	invasion	invasion	NOUN
ajst-17938	63	25	of	of	ADP
ajst-17938	63	26	tumor	tumor	NOUN
ajst-17938	63	27	cells	cell	NOUN
ajst-17938	63	28	,	,	PUNCT
ajst-17938	63	29	induce	induce	VERB
ajst-17938	63	30	apoptosis	apoptosis	NOUN
ajst-17938	63	31	of	of	ADP
ajst-17938	63	32	tumor	tumor	NOUN
ajst-17938	63	33	cells	cell	NOUN
ajst-17938	63	34	,	,	PUNCT
ajst-17938	63	35	inhibit	inhibit	VERB
ajst-17938	63	36	the	the	DET
ajst-17938	63	37	proliferation	proliferation	NOUN
ajst-17938	63	38	of	of	ADP
ajst-17938	63	39	tumor	tumor	NOUN
ajst-17938	63	40	cells	cell	NOUN
ajst-17938	63	41	,	,	PUNCT
ajst-17938	63	42	promote	promote	VERB
ajst-17938	63	43	autophagy	autophagy	ADJ
ajst-17938	63	44	and	and	CCONJ
ajst-17938	63	45	cell	cell	NOUN
ajst-17938	63	46	cycle	cycle	NOUN
ajst-17938	63	47	arrest	arrest	NOUN
ajst-17938	63	48	of	of	ADP
ajst-17938	63	49	tumor	tumor	NOUN
ajst-17938	63	50	cells	cell	NOUN
ajst-17938	63	51	,	,	PUNCT
ajst-17938	63	52	and	and	CCONJ
ajst-17938	63	53	affect	affect	VERB
ajst-17938	63	54	tumor	tumor	NOUN
ajst-17938	63	55	angiogenesis	angiogenesis	NOUN
ajst-17938	63	56	.	.	PUNCT
ajst-17938	64	1	these	these	DET
ajst-17938	64	2	mechanisms	mechanism	NOUN
ajst-17938	64	3	give	give	VERB
ajst-17938	64	4	the	the	DET
ajst-17938	64	5	forbidden	forbid	VERB
ajst-17938	64	6	imidepolyamine	imidepolyamine	ADJ
ajst-17938	64	7	conjugates	conjugate	NOUN
ajst-17938	64	8	broad	broad	ADJ
ajst-17938	64	9	application	application	NOUN
ajst-17938	64	10	in	in	ADP
ajst-17938	64	11	the	the	DET
ajst-17938	64	12	treatment	treatment	NOUN
ajst-17938	64	13	of	of	ADP
ajst-17938	64	14	hcc	hcc	PROPN
ajst-17938	64	15	.	.	PUNCT
ajst-17938	65	1	3	3	X
ajst-17938	65	2	.	.	X
ajst-17938	65	3	anti	anti	ADJ
ajst-17938	65	4	-	-	ADJ
ajst-17938	65	5	transfer	transfer	ADJ
ajst-17938	65	6	drug	drug	NOUN
ajst-17938	65	7	development	development	NOUN
ajst-17938	65	8	based	base	VERB
ajst-17938	65	9	on	on	ADP
ajst-17938	65	10	banned	ban	VERB
ajst-17938	65	11	imide	imide	ADJ
ajst-17938	65	12	-	-	PUNCT
ajst-17938	65	13	polyamine	polyamine	NOUN
ajst-17938	65	14	conjugates	conjugate	NOUN
ajst-17938	65	15	this	this	DET
ajst-17938	65	16	study	study	NOUN
ajst-17938	65	17	aimed	aim	VERB
ajst-17938	65	18	to	to	PART
ajst-17938	65	19	develop	develop	VERB
ajst-17938	65	20	a	a	DET
ajst-17938	65	21	novel	novel	ADJ
ajst-17938	65	22	anti	anti	ADJ
ajst-17938	65	23	-	-	ADJ
ajst-17938	65	24	metastasis	metastasis	ADJ
ajst-17938	65	25	agent	agent	NOUN
ajst-17938	65	26	based	base	VERB
ajst-17938	65	27	on	on	ADP
ajst-17938	65	28	banned	ban	VERB
ajst-17938	65	29	imide	imide	ADJ
ajst-17938	65	30	-	-	PUNCT
ajst-17938	65	31	polyamine	polyamine	NOUN
ajst-17938	65	32	conjugates	conjugate	NOUN
ajst-17938	65	33	and	and	CCONJ
ajst-17938	65	34	explore	explore	VERB
ajst-17938	65	35	its	its	PRON
ajst-17938	65	36	application	application	NOUN
ajst-17938	65	37	in	in	ADP
ajst-17938	65	38	the	the	DET
ajst-17938	65	39	treatment	treatment	NOUN
ajst-17938	65	40	of	of	ADP
ajst-17938	65	41	hcancer	hcancer	NOUN
ajst-17938	65	42	.	.	PUNCT
ajst-17938	66	1	the	the	DET
ajst-17938	66	2	forbidden	forbid	VERB
ajst-17938	66	3	imidepolyamine	imidepolyamine	ADJ
ajst-17938	66	4	conjugate	conjugate	NOUN
ajst-17938	66	5	is	be	AUX
ajst-17938	66	6	a	a	DET
ajst-17938	66	7	novel	novel	ADJ
ajst-17938	66	8	anti	anti	ADJ
ajst-17938	66	9	-	-	ADJ
ajst-17938	66	10	tumor	tumor	ADJ
ajst-17938	66	11	agent	agent	NOUN
ajst-17938	66	12	with	with	ADP
ajst-17938	66	13	good	good	ADJ
ajst-17938	66	14	biocompatibility	biocompatibility	NOUN
ajst-17938	66	15	and	and	CCONJ
ajst-17938	66	16	unique	unique	ADJ
ajst-17938	66	17	molecular	molecular	ADJ
ajst-17938	66	18	structure	structure	NOUN
ajst-17938	66	19	.	.	PUNCT
ajst-17938	67	1	they	they	PRON
ajst-17938	67	2	are	be	AUX
ajst-17938	67	3	composed	compose	VERB
ajst-17938	67	4	of	of	ADP
ajst-17938	67	5	two	two	NUM
ajst-17938	67	6	parts	part	NOUN
ajst-17938	67	7	:	:	PUNCT
ajst-17938	67	8	forbidden	forbid	VERB
ajst-17938	67	9	amine	amine	ADJ
ajst-17938	67	10	and	and	CCONJ
ajst-17938	67	11	polyamine	polyamine	NOUN
ajst-17938	67	12	,	,	PUNCT
ajst-17938	67	13	in	in	ADP
ajst-17938	67	14	which	which	PRON
ajst-17938	67	15	the	the	DET
ajst-17938	67	16	forbidden	forbid	VERB
ajst-17938	67	17	amine	amine	ADJ
ajst-17938	67	18	part	part	NOUN
ajst-17938	67	19	has	have	VERB
ajst-17938	67	20	good	good	ADJ
ajst-17938	67	21	water	water	NOUN
ajst-17938	67	22	solubility	solubility	NOUN
ajst-17938	67	23	and	and	CCONJ
ajst-17938	67	24	biodegradability	biodegradability	NOUN
ajst-17938	67	25	,	,	PUNCT
ajst-17938	67	26	while	while	SCONJ
ajst-17938	67	27	the	the	DET
ajst-17938	67	28	polyamine	polyamine	NOUN
ajst-17938	67	29	part	part	NOUN
ajst-17938	67	30	has	have	VERB
ajst-17938	67	31	biological	biological	ADJ
ajst-17938	67	32	activities	activity	NOUN
ajst-17938	67	33	such	such	ADJ
ajst-17938	67	34	as	as	ADP
ajst-17938	67	35	regulating	regulate	VERB
ajst-17938	67	36	intracellular	intracellular	ADJ
ajst-17938	67	37	ph	ph	NOUN
ajst-17938	67	38	and	and	CCONJ
ajst-17938	67	39	affecting	affect	VERB
ajst-17938	67	40	cell	cell	NOUN
ajst-17938	67	41	signaling	signal	VERB
ajst-17938	67	42	.	.	PUNCT
ajst-17938	68	1	therefore	therefore	ADV
ajst-17938	68	2	,	,	PUNCT
ajst-17938	68	3	forbidden	forbid	VERB
ajst-17938	68	4	imide	imide	ADJ
ajst-17938	68	5	-	-	PUNCT
ajst-17938	68	6	polyamine	polyamine	NOUN
ajst-17938	68	7	conjugates	conjugate	NOUN
ajst-17938	68	8	have	have	VERB
ajst-17938	68	9	wide	wide	ADJ
ajst-17938	68	10	application	application	NOUN
ajst-17938	68	11	prospects	prospect	NOUN
ajst-17938	68	12	in	in	ADP
ajst-17938	68	13	antitumor	antitumor	PROPN
ajst-17938	68	14	therapy	therapy	NOUN
ajst-17938	68	15	.	.	PUNCT
ajst-17938	69	1	first	first	ADV
ajst-17938	69	2	,	,	PUNCT
ajst-17938	69	3	we	we	PRON
ajst-17938	69	4	designed	design	VERB
ajst-17938	69	5	and	and	CCONJ
ajst-17938	69	6	synthesized	synthesize	VERB
ajst-17938	69	7	a	a	DET
ajst-17938	69	8	series	series	NOUN
ajst-17938	69	9	of	of	ADP
ajst-17938	69	10	forbidden	forbid	VERB
ajst-17938	69	11	imide	imide	ADJ
ajst-17938	69	12	-	-	PUNCT
ajst-17938	69	13	polyamine	polyamine	NOUN
ajst-17938	69	14	conjugates	conjugate	NOUN
ajst-17938	69	15	and	and	CCONJ
ajst-17938	69	16	evaluated	evaluate	VERB
ajst-17938	69	17	their	their	PRON
ajst-17938	69	18	inhibitory	inhibitory	ADJ
ajst-17938	69	19	effects	effect	NOUN
ajst-17938	69	20	on	on	ADP
ajst-17938	69	21	the	the	DET
ajst-17938	69	22	migration	migration	NOUN
ajst-17938	69	23	and	and	CCONJ
ajst-17938	69	24	invasion	invasion	NOUN
ajst-17938	69	25	capacity	capacity	NOUN
ajst-17938	69	26	of	of	ADP
ajst-17938	69	27	hcc	hcc	PROPN
ajst-17938	69	28	cells	cell	NOUN
ajst-17938	69	29	by	by	ADP
ajst-17938	69	30	cell	cell	NOUN
ajst-17938	69	31	assay	assay	NOUN
ajst-17938	69	32	.	.	PUNCT
ajst-17938	70	1	the	the	DET
ajst-17938	70	2	results	result	NOUN
ajst-17938	70	3	showed	show	VERB
ajst-17938	70	4	that	that	SCONJ
ajst-17938	70	5	these	these	DET
ajst-17938	70	6	compounds	compound	NOUN
ajst-17938	70	7	were	be	AUX
ajst-17938	70	8	able	able	ADJ
ajst-17938	70	9	to	to	PART
ajst-17938	70	10	significantly	significantly	ADV
ajst-17938	70	11	reduce	reduce	VERB
ajst-17938	70	12	the	the	DET
ajst-17938	70	13	metastatic	metastatic	ADJ
ajst-17938	70	14	ability	ability	NOUN
ajst-17938	70	15	of	of	ADP
ajst-17938	70	16	hcc	hcc	PROPN
ajst-17938	70	17	cells	cell	NOUN
ajst-17938	70	18	.	.	PUNCT
ajst-17938	71	1	further	further	PROPN
ajst-17938	71	2	mechanistic	mechanistic	ADJ
ajst-17938	71	3	studies	study	NOUN
ajst-17938	71	4	revealed	reveal	VERB
ajst-17938	71	5	that	that	SCONJ
ajst-17938	71	6	these	these	DET
ajst-17938	71	7	compounds	compound	NOUN
ajst-17938	71	8	are	be	AUX
ajst-17938	71	9	able	able	ADJ
ajst-17938	71	10	to	to	PART
ajst-17938	71	11	inhibit	inhibit	VERB
ajst-17938	71	12	the	the	DET
ajst-17938	71	13	metastasis	metastasis	NOUN
ajst-17938	71	14	of	of	ADP
ajst-17938	71	15	hcc	hcc	PROPN
ajst-17938	71	16	cells	cell	NOUN
ajst-17938	71	17	by	by	ADP
ajst-17938	71	18	interfering	interfere	VERB
ajst-17938	71	19	with	with	ADP
ajst-17938	71	20	intracellular	intracellular	ADJ
ajst-17938	71	21	signaling	signal	VERB
ajst-17938	71	22	pathways	pathway	NOUN
ajst-17938	71	23	and	and	CCONJ
ajst-17938	71	24	affecting	affect	VERB
ajst-17938	71	25	cytoskeletal	cytoskeletal	ADJ
ajst-17938	71	26	reorganization	reorganization	NOUN
ajst-17938	71	27	.	.	PUNCT
ajst-17938	72	1	to	to	PART
ajst-17938	72	2	further	far	ADV
ajst-17938	72	3	optimize	optimize	VERB
ajst-17938	72	4	the	the	DET
ajst-17938	72	5	structure	structure	NOUN
ajst-17938	72	6	and	and	CCONJ
ajst-17938	72	7	activity	activity	NOUN
ajst-17938	72	8	of	of	ADP
ajst-17938	72	9	these	these	DET
ajst-17938	72	10	compounds	compound	NOUN
ajst-17938	72	11	,	,	PUNCT
ajst-17938	72	12	we	we	PRON
ajst-17938	72	13	optimized	optimize	VERB
ajst-17938	72	14	their	their	PRON
ajst-17938	72	15	structures	structure	NOUN
ajst-17938	72	16	using	use	VERB
ajst-17938	72	17	computer	computer	NOUN
ajst-17938	72	18	-	-	PUNCT
ajst-17938	72	19	aided	aid	VERB
ajst-17938	72	20	design	design	NOUN
ajst-17938	72	21	techniques	technique	NOUN
ajst-17938	72	22	.	.	PUNCT
ajst-17938	73	1	through	through	ADP
ajst-17938	73	2	molecular	molecular	ADJ
ajst-17938	73	3	docking	docking	NOUN
ajst-17938	73	4	and	and	CCONJ
ajst-17938	73	5	molecular	molecular	ADJ
ajst-17938	73	6	dynamics	dynamic	NOUN
ajst-17938	73	7	simulations	simulation	NOUN
ajst-17938	73	8	,	,	PUNCT
ajst-17938	73	9	we	we	PRON
ajst-17938	73	10	found	find	VERB
ajst-17938	73	11	a	a	DET
ajst-17938	73	12	number	number	NOUN
ajst-17938	73	13	of	of	ADP
ajst-17938	73	14	compounds	compound	NOUN
ajst-17938	73	15	with	with	ADP
ajst-17938	73	16	higher	high	ADJ
ajst-17938	73	17	activity	activity	NOUN
ajst-17938	73	18	and	and	CCONJ
ajst-17938	73	19	selectivity	selectivity	NOUN
ajst-17938	73	20	.	.	PUNCT
ajst-17938	74	1	these	these	DET
ajst-17938	74	2	optimized	optimize	VERB
ajst-17938	74	3	compounds	compound	NOUN
ajst-17938	74	4	further	far	ADV
ajst-17938	74	5	validate	validate	VERB
ajst-17938	74	6	their	their	PRON
ajst-17938	74	7	anti	anti	ADJ
ajst-17938	74	8	-	-	ADJ
ajst-17938	74	9	metastatic	metastatic	ADJ
ajst-17938	74	10	effect	effect	NOUN
ajst-17938	74	11	in	in	ADP
ajst-17938	74	12	cellular	cellular	ADJ
ajst-17938	74	13	experiments	experiment	NOUN
ajst-17938	74	14	and	and	CCONJ
ajst-17938	74	15	have	have	VERB
ajst-17938	74	16	less	less	ADJ
ajst-17938	74	17	effect	effect	NOUN
ajst-17938	74	18	on	on	ADP
ajst-17938	74	19	normal	normal	ADJ
ajst-17938	74	20	cells	cell	NOUN
ajst-17938	74	21	,	,	PUNCT
ajst-17938	74	22	showing	show	VERB
ajst-17938	74	23	better	well	ADJ
ajst-17938	74	24	biocompatibility	biocompatibility	NOUN
ajst-17938	74	25	.	.	PUNCT
ajst-17938	75	1	we	we	PRON
ajst-17938	75	2	also	also	ADV
ajst-17938	75	3	explored	explore	VERB
ajst-17938	75	4	the	the	DET
ajst-17938	75	5	mechanism	mechanism	NOUN
ajst-17938	75	6	of	of	ADP
ajst-17938	75	7	action	action	NOUN
ajst-17938	75	8	of	of	ADP
ajst-17938	75	9	these	these	DET
ajst-17938	75	10	compounds	compound	NOUN
ajst-17938	75	11	in	in	ADP
ajst-17938	75	12	hcc	hcc	PROPN
ajst-17938	75	13	treatment	treatment	NOUN
ajst-17938	75	14	.	.	PUNCT
ajst-17938	76	1	these	these	DET
ajst-17938	76	2	compounds	compound	NOUN
ajst-17938	76	3	were	be	AUX
ajst-17938	76	4	found	find	VERB
ajst-17938	76	5	to	to	PART
ajst-17938	76	6	be	be	AUX
ajst-17938	76	7	able	able	ADJ
ajst-17938	76	8	to	to	PART
ajst-17938	76	9	induce	induce	VERB
ajst-17938	76	10	apoptosis	apoptosis	NOUN
ajst-17938	76	11	in	in	ADP
ajst-17938	76	12	hcc	hcc	PROPN
ajst-17938	76	13	cells	cell	NOUN
ajst-17938	76	14	and	and	CCONJ
ajst-17938	76	15	to	to	PART
ajst-17938	76	16	inhibit	inhibit	VERB
ajst-17938	76	17	their	their	PRON
ajst-17938	76	18	proliferation	proliferation	NOUN
ajst-17938	76	19	.	.	PUNCT
ajst-17938	77	1	at	at	ADP
ajst-17938	77	2	the	the	DET
ajst-17938	77	3	same	same	ADJ
ajst-17938	77	4	time	time	NOUN
ajst-17938	77	5	,	,	PUNCT
ajst-17938	77	6	they	they	PRON
ajst-17938	77	7	can	can	AUX
ajst-17938	77	8	also	also	ADV
ajst-17938	77	9	promote	promote	VERB
ajst-17938	77	10	the	the	DET
ajst-17938	77	11	autophagy	autophagy	NOUN
ajst-17938	77	12	and	and	CCONJ
ajst-17938	77	13	cell	cell	NOUN
ajst-17938	77	14	cycle	cycle	NOUN
ajst-17938	77	15	arrest	arrest	NOUN
ajst-17938	77	16	of	of	ADP
ajst-17938	77	17	hcc	hcc	PROPN
ajst-17938	77	18	cells	cell	NOUN
ajst-17938	77	19	,	,	PUNCT
ajst-17938	77	20	thus	thus	ADV
ajst-17938	77	21	inhibiting	inhibit	VERB
ajst-17938	77	22	the	the	DET
ajst-17938	77	23	development	development	NOUN
ajst-17938	77	24	of	of	ADP
ajst-17938	77	25	hcc	hcc	PROPN
ajst-17938	77	26	in	in	ADP
ajst-17938	77	27	many	many	ADJ
ajst-17938	77	28	ways[2	ways[2	PROPN
ajst-17938	77	29	]	]	PUNCT
ajst-17938	77	30	.	.	PUNCT
ajst-17938	78	1	in	in	ADP
ajst-17938	78	2	animal	animal	NOUN
ajst-17938	78	3	models	model	NOUN
ajst-17938	78	4	,	,	PUNCT
ajst-17938	78	5	we	we	PRON
ajst-17938	78	6	employed	employ	VERB
ajst-17938	78	7	a	a	DET
ajst-17938	78	8	mouse	mouse	NOUN
ajst-17938	78	9	liver	liver	NOUN
ajst-17938	78	10	cancer	cancer	NOUN
ajst-17938	78	11	model	model	NOUN
ajst-17938	78	12	to	to	PART
ajst-17938	78	13	evaluate	evaluate	VERB
ajst-17938	78	14	the	the	DET
ajst-17938	78	15	anti	anti	ADJ
ajst-17938	78	16	-	-	ADJ
ajst-17938	78	17	metastatic	metastatic	ADJ
ajst-17938	78	18	effects	effect	NOUN
ajst-17938	78	19	of	of	ADP
ajst-17938	78	20	these	these	DET
ajst-17938	78	21	compounds	compound	NOUN
ajst-17938	78	22	.	.	PUNCT
ajst-17938	79	1	the	the	DET
ajst-17938	79	2	experimental	experimental	ADJ
ajst-17938	79	3	results	result	NOUN
ajst-17938	79	4	showed	show	VERB
ajst-17938	79	5	that	that	SCONJ
ajst-17938	79	6	these	these	DET
ajst-17938	79	7	compounds	compound	NOUN
ajst-17938	79	8	can	can	AUX
ajst-17938	79	9	significantly	significantly	ADV
ajst-17938	79	10	reduce	reduce	VERB
ajst-17938	79	11	the	the	DET
ajst-17938	79	12	metastasis	metastasis	NOUN
ajst-17938	79	13	and	and	CCONJ
ajst-17938	79	14	recurrence	recurrence	NOUN
ajst-17938	79	15	of	of	ADP
ajst-17938	79	16	liver	liver	NOUN
ajst-17938	79	17	cancer	cancer	NOUN
ajst-17938	79	18	in	in	ADP
ajst-17938	79	19	mice	mouse	NOUN
ajst-17938	79	20	,	,	PUNCT
ajst-17938	79	21	and	and	CCONJ
ajst-17938	79	22	improve	improve	VERB
ajst-17938	79	23	the	the	DET
ajst-17938	79	24	survival	survival	NOUN
ajst-17938	79	25	rate	rate	NOUN
ajst-17938	79	26	of	of	ADP
ajst-17938	79	27	mice	mouse	NOUN
ajst-17938	79	28	.	.	PUNCT
ajst-17938	80	1	moreover	moreover	ADV
ajst-17938	80	2	,	,	PUNCT
ajst-17938	80	3	these	these	DET
ajst-17938	80	4	compounds	compound	NOUN
ajst-17938	80	5	were	be	AUX
ajst-17938	80	6	also	also	ADV
ajst-17938	80	7	able	able	ADJ
ajst-17938	80	8	to	to	PART
ajst-17938	80	9	improve	improve	VERB
ajst-17938	80	10	liver	liver	NOUN
ajst-17938	80	11	function	function	NOUN
ajst-17938	80	12	and	and	CCONJ
ajst-17938	80	13	reduce	reduce	VERB
ajst-17938	80	14	liver	liver	NOUN
ajst-17938	80	15	inflammatory	inflammatory	ADJ
ajst-17938	80	16	responses	response	NOUN
ajst-17938	80	17	in	in	ADP
ajst-17938	80	18	hcc	hcc	PROPN
ajst-17938	80	19	mice	mouse	NOUN
ajst-17938	80	20	.	.	PUNCT
ajst-17938	81	1	in	in	ADP
ajst-17938	81	2	conclusion	conclusion	NOUN
ajst-17938	81	3	,	,	PUNCT
ajst-17938	81	4	the	the	DET
ajst-17938	81	5	forbidden	forbid	VERB
ajst-17938	81	6	imide	imide	ADJ
ajst-17938	81	7	-	-	PUNCT
ajst-17938	81	8	polyamine	polyamine	NOUN
ajst-17938	81	9	conjugates	conjugate	NOUN
ajst-17938	81	10	developed	develop	VERB
ajst-17938	81	11	in	in	ADP
ajst-17938	81	12	this	this	DET
ajst-17938	81	13	study	study	NOUN
ajst-17938	81	14	have	have	VERB
ajst-17938	81	15	the	the	DET
ajst-17938	81	16	potential	potential	NOUN
ajst-17938	81	17	to	to	PART
ajst-17938	81	18	serve	serve	VERB
ajst-17938	81	19	as	as	ADP
ajst-17938	81	20	novel	novel	ADJ
ajst-17938	81	21	anti	anti	ADJ
ajst-17938	81	22	-	-	ADJ
ajst-17938	81	23	hcc	hcc	ADJ
ajst-17938	81	24	metastasis	metastasis	NOUN
ajst-17938	81	25	agents	agent	NOUN
ajst-17938	81	26	.	.	PUNCT
ajst-17938	82	1	in	in	ADP
ajst-17938	82	2	the	the	DET
ajst-17938	82	3	future	future	NOUN
ajst-17938	82	4	,	,	PUNCT
ajst-17938	82	5	we	we	PRON
ajst-17938	82	6	will	will	AUX
ajst-17938	82	7	continue	continue	VERB
ajst-17938	82	8	to	to	PART
ajst-17938	82	9	optimize	optimize	VERB
ajst-17938	82	10	the	the	DET
ajst-17938	82	11	structure	structure	NOUN
ajst-17938	82	12	and	and	CCONJ
ajst-17938	82	13	activity	activity	NOUN
ajst-17938	82	14	of	of	ADP
ajst-17938	82	15	these	these	DET
ajst-17938	82	16	compounds	compound	NOUN
ajst-17938	82	17	and	and	CCONJ
ajst-17938	82	18	conduct	conduct	VERB
ajst-17938	82	19	clinical	clinical	ADJ
ajst-17938	82	20	trials	trial	NOUN
ajst-17938	82	21	to	to	PART
ajst-17938	82	22	validate	validate	VERB
ajst-17938	82	23	their	their	PRON
ajst-17938	82	24	efficacy	efficacy	NOUN
ajst-17938	82	25	and	and	CCONJ
ajst-17938	82	26	safety	safety	NOUN
ajst-17938	82	27	.	.	PUNCT
ajst-17938	83	1	in	in	ADP
ajst-17938	83	2	addition	addition	NOUN
ajst-17938	83	3	,	,	PUNCT
ajst-17938	83	4	we	we	PRON
ajst-17938	83	5	will	will	AUX
ajst-17938	83	6	further	far	ADV
ajst-17938	83	7	explore	explore	VERB
ajst-17938	83	8	the	the	DET
ajst-17938	83	9	mechanisms	mechanism	NOUN
ajst-17938	83	10	of	of	ADP
ajst-17938	83	11	these	these	DET
ajst-17938	83	12	compounds	compound	NOUN
ajst-17938	83	13	in	in	ADP
ajst-17938	83	14	order	order	NOUN
ajst-17938	83	15	to	to	PART
ajst-17938	83	16	provide	provide	VERB
ajst-17938	83	17	new	new	ADJ
ajst-17938	83	18	strategies	strategy	NOUN
ajst-17938	83	19	for	for	ADP
ajst-17938	83	20	the	the	DET
ajst-17938	83	21	prevention	prevention	NOUN
ajst-17938	83	22	and	and	CCONJ
ajst-17938	83	23	treatment	treatment	NOUN
ajst-17938	83	24	of	of	ADP
ajst-17938	83	25	hcc	hcc	PROPN
ajst-17938	83	26	.	.	PROPN
ajst-17938	84	1	263	263	NUM
ajst-17938	84	2	4	4	NUM
ajst-17938	84	3	.	.	PUNCT
ajst-17938	84	4	application	application	NOUN
ajst-17938	84	5	of	of	ADP
ajst-17938	84	6	forbidden	forbid	VERB
ajst-17938	84	7	imidepolyamine	imidepolyamine	ADJ
ajst-17938	84	8	conjugates	conjugate	NOUN
ajst-17938	84	9	in	in	ADP
ajst-17938	84	10	the	the	DET
ajst-17938	84	11	treatment	treatment	NOUN
ajst-17938	84	12	of	of	ADP
ajst-17938	84	13	liver	liver	NOUN
ajst-17938	84	14	cancer	cancer	NOUN
ajst-17938	84	15	this	this	DET
ajst-17938	84	16	study	study	NOUN
ajst-17938	84	17	aimed	aim	VERB
ajst-17938	84	18	to	to	PART
ajst-17938	84	19	develop	develop	VERB
ajst-17938	84	20	a	a	DET
ajst-17938	84	21	novel	novel	ADJ
ajst-17938	84	22	anti	anti	ADJ
ajst-17938	84	23	-	-	ADJ
ajst-17938	84	24	metastasis	metastasis	ADJ
ajst-17938	84	25	agent	agent	NOUN
ajst-17938	84	26	based	base	VERB
ajst-17938	84	27	on	on	ADP
ajst-17938	84	28	banned	ban	VERB
ajst-17938	84	29	imide	imide	ADJ
ajst-17938	84	30	-	-	PUNCT
ajst-17938	84	31	polyamine	polyamine	NOUN
ajst-17938	84	32	conjugates	conjugate	NOUN
ajst-17938	84	33	and	and	CCONJ
ajst-17938	84	34	explore	explore	VERB
ajst-17938	84	35	its	its	PRON
ajst-17938	84	36	application	application	NOUN
ajst-17938	84	37	in	in	ADP
ajst-17938	84	38	the	the	DET
ajst-17938	84	39	treatment	treatment	NOUN
ajst-17938	84	40	of	of	ADP
ajst-17938	84	41	hcancer	hcancer	NOUN
ajst-17938	84	42	.	.	PUNCT
ajst-17938	85	1	liver	liver	NOUN
ajst-17938	85	2	cancer	cancer	NOUN
ajst-17938	85	3	is	be	AUX
ajst-17938	85	4	one	one	NUM
ajst-17938	85	5	of	of	ADP
ajst-17938	85	6	the	the	DET
ajst-17938	85	7	most	most	ADV
ajst-17938	85	8	common	common	ADJ
ajst-17938	85	9	malignancies	malignancy	NOUN
ajst-17938	85	10	worldwide	worldwide	ADV
ajst-17938	85	11	with	with	ADP
ajst-17938	85	12	extremely	extremely	ADV
ajst-17938	85	13	high	high	ADJ
ajst-17938	85	14	mortality	mortality	NOUN
ajst-17938	85	15	.	.	PUNCT
ajst-17938	86	1	in	in	ADP
ajst-17938	86	2	china	china	PROPN
ajst-17938	86	3	,	,	PUNCT
ajst-17938	86	4	the	the	DET
ajst-17938	86	5	incidence	incidence	NOUN
ajst-17938	86	6	and	and	CCONJ
ajst-17938	86	7	mortality	mortality	NOUN
ajst-17938	86	8	of	of	ADP
ajst-17938	86	9	liver	liver	NOUN
ajst-17938	86	10	cancer	cancer	NOUN
ajst-17938	86	11	rank	rank	NOUN
ajst-17938	86	12	first	first	ADV
ajst-17938	86	13	among	among	ADP
ajst-17938	86	14	malignant	malignant	ADJ
ajst-17938	86	15	tumors	tumor	NOUN
ajst-17938	86	16	.	.	PUNCT
ajst-17938	87	1	metastasis	metastasis	PRON
ajst-17938	87	2	of	of	ADP
ajst-17938	87	3	hcc	hcc	PROPN
ajst-17938	87	4	is	be	AUX
ajst-17938	87	5	one	one	NUM
ajst-17938	87	6	of	of	ADP
ajst-17938	87	7	the	the	DET
ajst-17938	87	8	main	main	ADJ
ajst-17938	87	9	causes	cause	NOUN
ajst-17938	87	10	of	of	ADP
ajst-17938	87	11	death	death	NOUN
ajst-17938	87	12	in	in	ADP
ajst-17938	87	13	patients	patient	NOUN
ajst-17938	87	14	,	,	PUNCT
ajst-17938	87	15	so	so	ADV
ajst-17938	87	16	the	the	DET
ajst-17938	87	17	development	development	NOUN
ajst-17938	87	18	of	of	ADP
ajst-17938	87	19	effective	effective	ADJ
ajst-17938	87	20	anti	anti	ADJ
ajst-17938	87	21	-	-	ADJ
ajst-17938	87	22	hcc	hcc	ADJ
ajst-17938	87	23	metastasis	metastasis	NOUN
ajst-17938	87	24	drugs	drug	NOUN
ajst-17938	87	25	is	be	AUX
ajst-17938	87	26	important	important	ADJ
ajst-17938	87	27	to	to	PART
ajst-17938	87	28	improve	improve	VERB
ajst-17938	87	29	patient	patient	ADJ
ajst-17938	87	30	survival	survival	NOUN
ajst-17938	87	31	and	and	CCONJ
ajst-17938	87	32	improve	improve	VERB
ajst-17938	87	33	prognosis	prognosis	NOUN
ajst-17938	87	34	.	.	PUNCT
ajst-17938	88	1	prohibited	prohibit	VERB
ajst-17938	88	2	imide	imide	ADJ
ajst-17938	88	3	-	-	PUNCT
ajst-17938	88	4	polyamine	polyamine	NOUN
ajst-17938	88	5	conjugates	conjugate	NOUN
ajst-17938	88	6	are	be	AUX
ajst-17938	88	7	a	a	DET
ajst-17938	88	8	novel	novel	ADJ
ajst-17938	88	9	class	class	NOUN
ajst-17938	88	10	of	of	ADP
ajst-17938	88	11	antitumor	antitumor	PROPN
ajst-17938	88	12	agents	agent	NOUN
ajst-17938	88	13	with	with	ADP
ajst-17938	88	14	excellent	excellent	ADJ
ajst-17938	88	15	biocompatibility	biocompatibility	NOUN
ajst-17938	88	16	and	and	CCONJ
ajst-17938	88	17	unique	unique	ADJ
ajst-17938	88	18	molecular	molecular	ADJ
ajst-17938	88	19	structure	structure	NOUN
ajst-17938	88	20	.	.	PUNCT
ajst-17938	89	1	they	they	PRON
ajst-17938	89	2	are	be	AUX
ajst-17938	89	3	composed	compose	VERB
ajst-17938	89	4	of	of	ADP
ajst-17938	89	5	two	two	NUM
ajst-17938	89	6	parts	part	NOUN
ajst-17938	89	7	:	:	PUNCT
ajst-17938	89	8	forbidden	forbid	VERB
ajst-17938	89	9	amine	amine	ADJ
ajst-17938	89	10	and	and	CCONJ
ajst-17938	89	11	polyamine	polyamine	NOUN
ajst-17938	89	12	,	,	PUNCT
ajst-17938	89	13	in	in	ADP
ajst-17938	89	14	which	which	PRON
ajst-17938	89	15	the	the	DET
ajst-17938	89	16	forbidden	forbid	VERB
ajst-17938	89	17	amine	amine	ADJ
ajst-17938	89	18	part	part	NOUN
ajst-17938	89	19	has	have	VERB
ajst-17938	89	20	good	good	ADJ
ajst-17938	89	21	water	water	NOUN
ajst-17938	89	22	solubility	solubility	NOUN
ajst-17938	89	23	and	and	CCONJ
ajst-17938	89	24	biodegradability	biodegradability	NOUN
ajst-17938	89	25	,	,	PUNCT
ajst-17938	89	26	while	while	SCONJ
ajst-17938	89	27	the	the	DET
ajst-17938	89	28	polyamine	polyamine	NOUN
ajst-17938	89	29	part	part	NOUN
ajst-17938	89	30	has	have	VERB
ajst-17938	89	31	biological	biological	ADJ
ajst-17938	89	32	activities	activity	NOUN
ajst-17938	89	33	such	such	ADJ
ajst-17938	89	34	as	as	ADP
ajst-17938	89	35	regulating	regulate	VERB
ajst-17938	89	36	intracellular	intracellular	ADJ
ajst-17938	89	37	ph	ph	NOUN
ajst-17938	89	38	and	and	CCONJ
ajst-17938	89	39	affecting	affect	VERB
ajst-17938	89	40	cell	cell	NOUN
ajst-17938	89	41	signaling	signal	VERB
ajst-17938	89	42	.	.	PUNCT
ajst-17938	90	1	therefore	therefore	ADV
ajst-17938	90	2	,	,	PUNCT
ajst-17938	90	3	forbidden	forbid	VERB
ajst-17938	90	4	imide	imide	ADJ
ajst-17938	90	5	-	-	PUNCT
ajst-17938	90	6	polyamine	polyamine	NOUN
ajst-17938	90	7	conjugates	conjugate	NOUN
ajst-17938	90	8	have	have	VERB
ajst-17938	90	9	wide	wide	ADJ
ajst-17938	90	10	application	application	NOUN
ajst-17938	90	11	prospects	prospect	NOUN
ajst-17938	90	12	in	in	ADP
ajst-17938	90	13	antitumor	antitumor	PROPN
ajst-17938	90	14	therapy	therapy	NOUN
ajst-17938	90	15	.	.	PUNCT
ajst-17938	91	1	in	in	ADP
ajst-17938	91	2	hcancer	hcancer	NOUN
ajst-17938	91	3	treatment	treatment	NOUN
ajst-17938	91	4	,	,	PUNCT
ajst-17938	91	5	the	the	DET
ajst-17938	91	6	forbidden	forbid	VERB
ajst-17938	91	7	imide	imide	ADJ
ajst-17938	91	8	-	-	PUNCT
ajst-17938	91	9	polyamine	polyamine	NOUN
ajst-17938	91	10	conjugate	conjugate	NOUN
ajst-17938	91	11	is	be	AUX
ajst-17938	91	12	able	able	ADJ
ajst-17938	91	13	to	to	PART
ajst-17938	91	14	inhibit	inhibit	VERB
ajst-17938	91	15	the	the	DET
ajst-17938	91	16	migration	migration	NOUN
ajst-17938	91	17	and	and	CCONJ
ajst-17938	91	18	invasion	invasion	NOUN
ajst-17938	91	19	ability	ability	NOUN
ajst-17938	91	20	of	of	ADP
ajst-17938	91	21	tumor	tumor	NOUN
ajst-17938	91	22	cells	cell	NOUN
ajst-17938	91	23	,	,	PUNCT
ajst-17938	91	24	which	which	PRON
ajst-17938	91	25	is	be	AUX
ajst-17938	91	26	one	one	NUM
ajst-17938	91	27	of	of	ADP
ajst-17938	91	28	the	the	DET
ajst-17938	91	29	important	important	ADJ
ajst-17938	91	30	mechanisms	mechanism	NOUN
ajst-17938	91	31	of	of	ADP
ajst-17938	91	32	their	their	PRON
ajst-17938	91	33	resistance	resistance	NOUN
ajst-17938	91	34	to	to	ADP
ajst-17938	91	35	metastasis	metastasis	NOUN
ajst-17938	91	36	.	.	PUNCT
ajst-17938	92	1	they	they	PRON
ajst-17938	92	2	are	be	AUX
ajst-17938	92	3	able	able	ADJ
ajst-17938	92	4	to	to	PART
ajst-17938	92	5	inhibit	inhibit	VERB
ajst-17938	92	6	the	the	DET
ajst-17938	92	7	migration	migration	NOUN
ajst-17938	92	8	and	and	CCONJ
ajst-17938	92	9	invasion	invasion	NOUN
ajst-17938	92	10	ability	ability	NOUN
ajst-17938	92	11	of	of	ADP
ajst-17938	92	12	tumor	tumor	NOUN
ajst-17938	92	13	cells	cell	NOUN
ajst-17938	92	14	by	by	ADP
ajst-17938	92	15	interfering	interfere	VERB
ajst-17938	92	16	with	with	ADP
ajst-17938	92	17	intracellular	intracellular	ADJ
ajst-17938	92	18	signaling	signal	VERB
ajst-17938	92	19	pathways	pathway	NOUN
ajst-17938	92	20	and	and	CCONJ
ajst-17938	92	21	affecting	affect	VERB
ajst-17938	92	22	cytoskeletal	cytoskeletal	ADJ
ajst-17938	92	23	reorganization	reorganization	NOUN
ajst-17938	92	24	.	.	PUNCT
ajst-17938	93	1	moreover	moreover	ADV
ajst-17938	93	2	,	,	PUNCT
ajst-17938	93	3	forbidden	forbidden	ADJ
ajst-17938	93	4	imidepolyamine	imidepolyamine	ADJ
ajst-17938	93	5	conjugates	conjugate	NOUN
ajst-17938	93	6	are	be	AUX
ajst-17938	93	7	also	also	ADV
ajst-17938	93	8	able	able	ADJ
ajst-17938	93	9	to	to	PART
ajst-17938	93	10	induce	induce	VERB
ajst-17938	93	11	apoptosis	apoptosis	NOUN
ajst-17938	93	12	in	in	ADP
ajst-17938	93	13	tumor	tumor	NOUN
ajst-17938	93	14	cells	cell	NOUN
ajst-17938	93	15	,	,	PUNCT
ajst-17938	93	16	another	another	DET
ajst-17938	93	17	important	important	ADJ
ajst-17938	93	18	mechanism	mechanism	NOUN
ajst-17938	93	19	for	for	ADP
ajst-17938	93	20	their	their	PRON
ajst-17938	93	21	resistance	resistance	NOUN
ajst-17938	93	22	to	to	ADP
ajst-17938	93	23	metastasis	metastasis	NOUN
ajst-17938	93	24	.	.	PUNCT
ajst-17938	94	1	they	they	PRON
ajst-17938	94	2	are	be	AUX
ajst-17938	94	3	able	able	ADJ
ajst-17938	94	4	to	to	PART
ajst-17938	94	5	induce	induce	VERB
ajst-17938	94	6	apoptosis	apoptosis	NOUN
ajst-17938	94	7	in	in	ADP
ajst-17938	94	8	tumor	tumor	NOUN
ajst-17938	94	9	cells	cell	NOUN
ajst-17938	94	10	by	by	ADP
ajst-17938	94	11	affecting	affect	VERB
ajst-17938	94	12	intracellular	intracellular	ADJ
ajst-17938	94	13	signaling	signal	VERB
ajst-17938	94	14	pathways	pathway	NOUN
ajst-17938	94	15	,	,	PUNCT
ajst-17938	94	16	such	such	ADJ
ajst-17938	94	17	as	as	ADP
ajst-17938	94	18	the	the	DET
ajst-17938	94	19	mitochondrial	mitochondrial	ADJ
ajst-17938	94	20	pathway	pathway	NOUN
ajst-17938	94	21	and	and	CCONJ
ajst-17938	94	22	the	the	DET
ajst-17938	94	23	death	death	NOUN
ajst-17938	94	24	receptor	receptor	NOUN
ajst-17938	94	25	pathway	pathway	NOUN
ajst-17938	94	26	.	.	PUNCT
ajst-17938	95	1	in	in	ADP
ajst-17938	95	2	addition	addition	NOUN
ajst-17938	95	3	to	to	ADP
ajst-17938	95	4	inducing	induce	VERB
ajst-17938	95	5	apoptosis	apoptosis	NOUN
ajst-17938	95	6	and	and	CCONJ
ajst-17938	95	7	inhibiting	inhibit	VERB
ajst-17938	95	8	proliferation	proliferation	NOUN
ajst-17938	95	9	,	,	PUNCT
ajst-17938	95	10	forbidden	forbid	VERB
ajst-17938	95	11	imide	imide	ADJ
ajst-17938	95	12	-	-	PUNCT
ajst-17938	95	13	polyamine	polyamine	NOUN
ajst-17938	95	14	conjugates	conjugate	NOUN
ajst-17938	95	15	are	be	AUX
ajst-17938	95	16	able	able	ADJ
ajst-17938	95	17	to	to	PART
ajst-17938	95	18	promote	promote	VERB
ajst-17938	95	19	autophagy	autophagy	ADJ
ajst-17938	95	20	and	and	CCONJ
ajst-17938	95	21	cell	cell	NOUN
ajst-17938	95	22	cycle	cycle	NOUN
ajst-17938	95	23	arrest	arrest	NOUN
ajst-17938	95	24	in	in	ADP
ajst-17938	95	25	tumor	tumor	NOUN
ajst-17938	95	26	cells	cell	NOUN
ajst-17938	95	27	.	.	PUNCT
ajst-17938	96	1	autophagy	autophagy	NOUN
ajst-17938	96	2	is	be	AUX
ajst-17938	96	3	a	a	DET
ajst-17938	96	4	degradation	degradation	NOUN
ajst-17938	96	5	and	and	CCONJ
ajst-17938	96	6	recycling	recycling	NOUN
ajst-17938	96	7	mechanism	mechanism	NOUN
ajst-17938	96	8	inside	inside	ADP
ajst-17938	96	9	the	the	DET
ajst-17938	96	10	cell	cell	NOUN
ajst-17938	96	11	that	that	PRON
ajst-17938	96	12	is	be	AUX
ajst-17938	96	13	capable	capable	ADJ
ajst-17938	96	14	of	of	ADP
ajst-17938	96	15	removing	remove	VERB
ajst-17938	96	16	damaged	damage	VERB
ajst-17938	96	17	organelles	organelle	NOUN
ajst-17938	96	18	and	and	CCONJ
ajst-17938	96	19	proteins	protein	NOUN
ajst-17938	96	20	.	.	PUNCT
ajst-17938	97	1	cell	cell	NOUN
ajst-17938	97	2	cycle	cycle	NOUN
ajst-17938	97	3	arrest	arrest	NOUN
ajst-17938	97	4	is	be	AUX
ajst-17938	97	5	the	the	DET
ajst-17938	97	6	role	role	NOUN
ajst-17938	97	7	of	of	ADP
ajst-17938	97	8	cell	cell	NOUN
ajst-17938	97	9	cycle	cycle	NOUN
ajst-17938	97	10	regulatory	regulatory	ADJ
ajst-17938	97	11	proteins	protein	NOUN
ajst-17938	97	12	that	that	PRON
ajst-17938	97	13	prevent	prevent	VERB
ajst-17938	97	14	the	the	DET
ajst-17938	97	15	cycle	cycle	NOUN
ajst-17938	97	16	progression	progression	NOUN
ajst-17938	97	17	of	of	ADP
ajst-17938	97	18	tumor	tumor	NOUN
ajst-17938	97	19	cells	cell	NOUN
ajst-17938	97	20	.	.	PUNCT
ajst-17938	98	1	these	these	DET
ajst-17938	98	2	mechanisms	mechanism	NOUN
ajst-17938	98	3	give	give	VERB
ajst-17938	98	4	the	the	DET
ajst-17938	98	5	forbidden	forbid	VERB
ajst-17938	98	6	imide	imide	ADJ
ajst-17938	98	7	-	-	PUNCT
ajst-17938	98	8	polyamine	polyamine	NOUN
ajst-17938	98	9	conjugates	conjugate	NOUN
ajst-17938	98	10	broad	broad	ADJ
ajst-17938	98	11	application	application	NOUN
ajst-17938	98	12	in	in	ADP
ajst-17938	98	13	the	the	DET
ajst-17938	98	14	treatment	treatment	NOUN
ajst-17938	98	15	of	of	ADP
ajst-17938	98	16	hcc	hcc	PROPN
ajst-17938	98	17	.	.	PUNCT
ajst-17938	99	1	in	in	ADP
ajst-17938	99	2	animal	animal	NOUN
ajst-17938	99	3	models	model	NOUN
ajst-17938	99	4	,	,	PUNCT
ajst-17938	99	5	we	we	PRON
ajst-17938	99	6	employed	employ	VERB
ajst-17938	99	7	a	a	DET
ajst-17938	99	8	mouse	mouse	NOUN
ajst-17938	99	9	liver	liver	NOUN
ajst-17938	99	10	cancer	cancer	NOUN
ajst-17938	99	11	model	model	NOUN
ajst-17938	99	12	to	to	PART
ajst-17938	99	13	evaluate	evaluate	VERB
ajst-17938	99	14	the	the	DET
ajst-17938	99	15	anti	anti	ADJ
ajst-17938	99	16	-	-	ADJ
ajst-17938	99	17	metastatic	metastatic	ADJ
ajst-17938	99	18	effects	effect	NOUN
ajst-17938	99	19	of	of	ADP
ajst-17938	99	20	these	these	DET
ajst-17938	99	21	compounds	compound	NOUN
ajst-17938	99	22	.	.	PUNCT
ajst-17938	100	1	the	the	DET
ajst-17938	100	2	experimental	experimental	ADJ
ajst-17938	100	3	results	result	NOUN
ajst-17938	100	4	showed	show	VERB
ajst-17938	100	5	that	that	SCONJ
ajst-17938	100	6	these	these	DET
ajst-17938	100	7	compounds	compound	NOUN
ajst-17938	100	8	can	can	AUX
ajst-17938	100	9	significantly	significantly	ADV
ajst-17938	100	10	reduce	reduce	VERB
ajst-17938	100	11	the	the	DET
ajst-17938	100	12	metastasis	metastasis	NOUN
ajst-17938	100	13	and	and	CCONJ
ajst-17938	100	14	recurrence	recurrence	NOUN
ajst-17938	100	15	of	of	ADP
ajst-17938	100	16	liver	liver	NOUN
ajst-17938	100	17	cancer	cancer	NOUN
ajst-17938	100	18	in	in	ADP
ajst-17938	100	19	mice	mouse	NOUN
ajst-17938	100	20	,	,	PUNCT
ajst-17938	100	21	and	and	CCONJ
ajst-17938	100	22	improve	improve	VERB
ajst-17938	100	23	the	the	DET
ajst-17938	100	24	survival	survival	NOUN
ajst-17938	100	25	rate	rate	NOUN
ajst-17938	100	26	of	of	ADP
ajst-17938	100	27	mice	mouse	NOUN
ajst-17938	100	28	.	.	PUNCT
ajst-17938	101	1	moreover	moreover	ADV
ajst-17938	101	2	,	,	PUNCT
ajst-17938	101	3	these	these	DET
ajst-17938	101	4	compounds	compound	NOUN
ajst-17938	101	5	were	be	AUX
ajst-17938	101	6	also	also	ADV
ajst-17938	101	7	able	able	ADJ
ajst-17938	101	8	to	to	PART
ajst-17938	101	9	improve	improve	VERB
ajst-17938	101	10	liver	liver	NOUN
ajst-17938	101	11	function	function	NOUN
ajst-17938	101	12	and	and	CCONJ
ajst-17938	101	13	reduce	reduce	VERB
ajst-17938	101	14	liver	liver	NOUN
ajst-17938	101	15	inflammatory	inflammatory	ADJ
ajst-17938	101	16	responses	response	NOUN
ajst-17938	101	17	in	in	ADP
ajst-17938	101	18	hcc	hcc	PROPN
ajst-17938	101	19	mice	mouse	NOUN
ajst-17938	101	20	.	.	PUNCT
ajst-17938	102	1	in	in	ADP
ajst-17938	102	2	conclusion	conclusion	NOUN
ajst-17938	102	3	,	,	PUNCT
ajst-17938	102	4	anti	anti	ADJ
ajst-17938	102	5	-	-	ADJ
ajst-17938	102	6	metastasis	metastasis	ADJ
ajst-17938	102	7	drugs	drug	NOUN
ajst-17938	102	8	based	base	VERB
ajst-17938	102	9	on	on	ADP
ajst-17938	102	10	banned	ban	VERB
ajst-17938	102	11	imide	imide	ADJ
ajst-17938	102	12	-	-	PUNCT
ajst-17938	102	13	polyamine	polyamine	NOUN
ajst-17938	102	14	conjugates	conjugate	NOUN
ajst-17938	102	15	are	be	AUX
ajst-17938	102	16	widely	widely	ADV
ajst-17938	102	17	applications	application	NOUN
ajst-17938	102	18	in	in	ADP
ajst-17938	102	19	the	the	DET
ajst-17938	102	20	treatment	treatment	NOUN
ajst-17938	102	21	of	of	ADP
ajst-17938	102	22	hcc	hcc	PROPN
ajst-17938	102	23	.	.	PUNCT
ajst-17938	103	1	in	in	ADP
ajst-17938	103	2	the	the	DET
ajst-17938	103	3	future	future	NOUN
ajst-17938	103	4	,	,	PUNCT
ajst-17938	103	5	we	we	PRON
ajst-17938	103	6	will	will	AUX
ajst-17938	103	7	continue	continue	VERB
ajst-17938	103	8	to	to	PART
ajst-17938	103	9	optimize	optimize	VERB
ajst-17938	103	10	the	the	DET
ajst-17938	103	11	structure	structure	NOUN
ajst-17938	103	12	and	and	CCONJ
ajst-17938	103	13	activity	activity	NOUN
ajst-17938	103	14	of	of	ADP
ajst-17938	103	15	these	these	DET
ajst-17938	103	16	compounds	compound	NOUN
ajst-17938	103	17	and	and	CCONJ
ajst-17938	103	18	conduct	conduct	VERB
ajst-17938	103	19	clinical	clinical	ADJ
ajst-17938	103	20	trials	trial	NOUN
ajst-17938	103	21	to	to	PART
ajst-17938	103	22	validate	validate	VERB
ajst-17938	103	23	their	their	PRON
ajst-17938	103	24	efficacy	efficacy	NOUN
ajst-17938	103	25	and	and	CCONJ
ajst-17938	103	26	safety	safety	NOUN
ajst-17938	103	27	.	.	PUNCT
ajst-17938	104	1	in	in	ADP
ajst-17938	104	2	addition	addition	NOUN
ajst-17938	104	3	,	,	PUNCT
ajst-17938	104	4	we	we	PRON
ajst-17938	104	5	will	will	AUX
ajst-17938	104	6	further	far	ADV
ajst-17938	104	7	explore	explore	VERB
ajst-17938	104	8	the	the	DET
ajst-17938	104	9	mechanisms	mechanism	NOUN
ajst-17938	104	10	of	of	ADP
ajst-17938	104	11	these	these	DET
ajst-17938	104	12	compounds	compound	NOUN
ajst-17938	104	13	in	in	ADP
ajst-17938	104	14	order	order	NOUN
ajst-17938	104	15	to	to	PART
ajst-17938	104	16	provide	provide	VERB
ajst-17938	104	17	new	new	ADJ
ajst-17938	104	18	strategies	strategy	NOUN
ajst-17938	104	19	for	for	ADP
ajst-17938	104	20	the	the	DET
ajst-17938	104	21	prevention	prevention	NOUN
ajst-17938	104	22	and	and	CCONJ
ajst-17938	104	23	treatment	treatment	NOUN
ajst-17938	104	24	of	of	ADP
ajst-17938	104	25	hcc[3	hcc[3	NOUN
ajst-17938	104	26	]	]	PUNCT
ajst-17938	104	27	.	.	PUNCT
ajst-17938	105	1	5	5	X
ajst-17938	105	2	.	.	X
ajst-17938	105	3	discussion	discussion	NOUN
ajst-17938	105	4	in	in	ADP
ajst-17938	105	5	this	this	DET
ajst-17938	105	6	study	study	NOUN
ajst-17938	105	7	,	,	PUNCT
ajst-17938	105	8	we	we	PRON
ajst-17938	105	9	developed	develop	VERB
ajst-17938	105	10	a	a	DET
ajst-17938	105	11	novel	novel	ADJ
ajst-17938	105	12	anti	anti	ADJ
ajst-17938	105	13	-	-	ADJ
ajst-17938	105	14	metastasis	metastasis	ADJ
ajst-17938	105	15	agent	agent	NOUN
ajst-17938	105	16	based	base	VERB
ajst-17938	105	17	on	on	ADP
ajst-17938	105	18	banned	ban	VERB
ajst-17938	105	19	imide	imide	ADJ
ajst-17938	105	20	-	-	PUNCT
ajst-17938	105	21	polyamine	polyamine	NOUN
ajst-17938	105	22	conjugates	conjugate	NOUN
ajst-17938	105	23	and	and	CCONJ
ajst-17938	105	24	explored	explore	VERB
ajst-17938	105	25	its	its	PRON
ajst-17938	105	26	application	application	NOUN
ajst-17938	105	27	in	in	ADP
ajst-17938	105	28	the	the	DET
ajst-17938	105	29	treatment	treatment	NOUN
ajst-17938	105	30	of	of	ADP
ajst-17938	105	31	hcc	hcc	PROPN
ajst-17938	105	32	.	.	PUNCT
ajst-17938	106	1	by	by	ADP
ajst-17938	106	2	designing	design	VERB
ajst-17938	106	3	and	and	CCONJ
ajst-17938	106	4	synthesizing	synthesize	VERB
ajst-17938	106	5	a	a	DET
ajst-17938	106	6	series	series	NOUN
ajst-17938	106	7	of	of	ADP
ajst-17938	106	8	banned	ban	VERB
ajst-17938	106	9	imide	imide	ADJ
ajst-17938	106	10	-	-	PUNCT
ajst-17938	106	11	polyamine	polyamine	NOUN
ajst-17938	106	12	conjugates	conjugate	NOUN
ajst-17938	106	13	,	,	PUNCT
ajst-17938	106	14	we	we	PRON
ajst-17938	106	15	found	find	VERB
ajst-17938	106	16	that	that	SCONJ
ajst-17938	106	17	these	these	DET
ajst-17938	106	18	compounds	compound	NOUN
ajst-17938	106	19	were	be	AUX
ajst-17938	106	20	able	able	ADJ
ajst-17938	106	21	to	to	PART
ajst-17938	106	22	significantly	significantly	ADV
ajst-17938	106	23	reduce	reduce	VERB
ajst-17938	106	24	the	the	DET
ajst-17938	106	25	migration	migration	NOUN
ajst-17938	106	26	and	and	CCONJ
ajst-17938	106	27	invasion	invasion	NOUN
ajst-17938	106	28	capacity	capacity	NOUN
ajst-17938	106	29	of	of	ADP
ajst-17938	106	30	hcc	hcc	PROPN
ajst-17938	106	31	cells	cell	NOUN
ajst-17938	106	32	.	.	PUNCT
ajst-17938	107	1	further	further	PROPN
ajst-17938	107	2	mechanistic	mechanistic	ADJ
ajst-17938	107	3	studies	study	NOUN
ajst-17938	107	4	revealed	reveal	VERB
ajst-17938	107	5	that	that	SCONJ
ajst-17938	107	6	these	these	DET
ajst-17938	107	7	compounds	compound	NOUN
ajst-17938	107	8	are	be	AUX
ajst-17938	107	9	able	able	ADJ
ajst-17938	107	10	to	to	PART
ajst-17938	107	11	inhibit	inhibit	VERB
ajst-17938	107	12	the	the	DET
ajst-17938	107	13	metastasis	metastasis	NOUN
ajst-17938	107	14	of	of	ADP
ajst-17938	107	15	hcc	hcc	PROPN
ajst-17938	107	16	cells	cell	NOUN
ajst-17938	107	17	by	by	ADP
ajst-17938	107	18	interfering	interfere	VERB
ajst-17938	107	19	with	with	ADP
ajst-17938	107	20	intracellular	intracellular	ADJ
ajst-17938	107	21	signaling	signal	VERB
ajst-17938	107	22	pathways	pathway	NOUN
ajst-17938	107	23	and	and	CCONJ
ajst-17938	107	24	affecting	affect	VERB
ajst-17938	107	25	cytoskeletal	cytoskeletal	ADJ
ajst-17938	107	26	reorganization	reorganization	NOUN
ajst-17938	107	27	.	.	PUNCT
ajst-17938	108	1	the	the	DET
ajst-17938	108	2	anti	anti	ADJ
ajst-17938	108	3	-	-	ADJ
ajst-17938	108	4	metastatic	metastatic	ADJ
ajst-17938	108	5	mechanisms	mechanism	NOUN
ajst-17938	108	6	of	of	ADP
ajst-17938	108	7	these	these	DET
ajst-17938	108	8	compounds	compound	NOUN
ajst-17938	108	9	include	include	VERB
ajst-17938	108	10	induction	induction	NOUN
ajst-17938	108	11	of	of	ADP
ajst-17938	108	12	apoptosis	apoptosis	NOUN
ajst-17938	108	13	of	of	ADP
ajst-17938	108	14	hcc	hcc	PROPN
ajst-17938	108	15	cells	cell	NOUN
ajst-17938	108	16	,	,	PUNCT
ajst-17938	108	17	inhibition	inhibition	NOUN
ajst-17938	108	18	of	of	ADP
ajst-17938	108	19	their	their	PRON
ajst-17938	108	20	proliferation	proliferation	NOUN
ajst-17938	108	21	,	,	PUNCT
ajst-17938	108	22	and	and	CCONJ
ajst-17938	108	23	promotion	promotion	NOUN
ajst-17938	108	24	of	of	ADP
ajst-17938	108	25	autophagy	autophagy	NOUN
ajst-17938	108	26	and	and	CCONJ
ajst-17938	108	27	cell	cell	NOUN
ajst-17938	108	28	cycle	cycle	NOUN
ajst-17938	108	29	arrest	arrest	NOUN
ajst-17938	108	30	of	of	ADP
ajst-17938	108	31	hcc	hcc	PROPN
ajst-17938	108	32	cells	cell	NOUN
ajst-17938	108	33	.	.	PUNCT
ajst-17938	109	1	these	these	DET
ajst-17938	109	2	mechanisms	mechanism	NOUN
ajst-17938	109	3	suggest	suggest	VERB
ajst-17938	109	4	a	a	DET
ajst-17938	109	5	multifaceted	multifaceted	ADJ
ajst-17938	109	6	role	role	NOUN
ajst-17938	109	7	of	of	ADP
ajst-17938	109	8	banned	ban	VERB
ajst-17938	109	9	imide	imide	ADJ
ajst-17938	109	10	-	-	PUNCT
ajst-17938	109	11	polyamine	polyamine	NOUN
ajst-17938	109	12	conjugates	conjugate	NOUN
ajst-17938	109	13	in	in	ADP
ajst-17938	109	14	the	the	DET
ajst-17938	109	15	treatment	treatment	NOUN
ajst-17938	109	16	of	of	ADP
ajst-17938	109	17	hcc	hcc	PROPN
ajst-17938	109	18	.	.	PUNCT
ajst-17938	110	1	in	in	ADP
ajst-17938	110	2	animal	animal	NOUN
ajst-17938	110	3	models	model	NOUN
ajst-17938	110	4	,	,	PUNCT
ajst-17938	110	5	these	these	DET
ajst-17938	110	6	compounds	compound	NOUN
ajst-17938	110	7	were	be	AUX
ajst-17938	110	8	able	able	ADJ
ajst-17938	110	9	to	to	PART
ajst-17938	110	10	significantly	significantly	ADV
ajst-17938	110	11	reduce	reduce	VERB
ajst-17938	110	12	hcc	hcc	PROPN
ajst-17938	110	13	metastasis	metastasis	NOUN
ajst-17938	110	14	and	and	CCONJ
ajst-17938	110	15	recurrence	recurrence	NOUN
ajst-17938	110	16	in	in	ADP
ajst-17938	110	17	mice	mouse	NOUN
ajst-17938	110	18	,	,	PUNCT
ajst-17938	110	19	improving	improve	VERB
ajst-17938	110	20	survival	survival	NOUN
ajst-17938	110	21	in	in	ADP
ajst-17938	110	22	mice	mouse	NOUN
ajst-17938	110	23	.	.	PUNCT
ajst-17938	111	1	moreover	moreover	ADV
ajst-17938	111	2	,	,	PUNCT
ajst-17938	111	3	these	these	DET
ajst-17938	111	4	compounds	compound	NOUN
ajst-17938	111	5	were	be	AUX
ajst-17938	111	6	also	also	ADV
ajst-17938	111	7	able	able	ADJ
ajst-17938	111	8	to	to	PART
ajst-17938	111	9	improve	improve	VERB
ajst-17938	111	10	liver	liver	NOUN
ajst-17938	111	11	function	function	NOUN
ajst-17938	111	12	and	and	CCONJ
ajst-17938	111	13	reduce	reduce	VERB
ajst-17938	111	14	liver	liver	NOUN
ajst-17938	111	15	inflammatory	inflammatory	ADJ
ajst-17938	111	16	responses	response	NOUN
ajst-17938	111	17	in	in	ADP
ajst-17938	111	18	hcc	hcc	PROPN
ajst-17938	111	19	mice	mouse	NOUN
ajst-17938	111	20	.	.	PUNCT
ajst-17938	112	1	however	however	ADV
ajst-17938	112	2	,	,	PUNCT
ajst-17938	112	3	although	although	SCONJ
ajst-17938	112	4	the	the	DET
ajst-17938	112	5	forbidden	forbid	VERB
ajst-17938	112	6	imide	imide	ADJ
ajst-17938	112	7	-	-	PUNCT
ajst-17938	112	8	polyamine	polyamine	NOUN
ajst-17938	112	9	conjugates	conjugate	NOUN
ajst-17938	112	10	have	have	AUX
ajst-17938	112	11	shown	show	VERB
ajst-17938	112	12	promising	promising	ADJ
ajst-17938	112	13	application	application	NOUN
ajst-17938	112	14	in	in	ADP
ajst-17938	112	15	the	the	DET
ajst-17938	112	16	treatment	treatment	NOUN
ajst-17938	112	17	of	of	ADP
ajst-17938	112	18	hcancer	hcancer	NOUN
ajst-17938	112	19	,	,	PUNCT
ajst-17938	112	20	there	there	PRON
ajst-17938	112	21	are	be	VERB
ajst-17938	112	22	still	still	ADV
ajst-17938	112	23	some	some	DET
ajst-17938	112	24	problems	problem	NOUN
ajst-17938	112	25	that	that	PRON
ajst-17938	112	26	need	need	VERB
ajst-17938	112	27	to	to	PART
ajst-17938	112	28	be	be	AUX
ajst-17938	112	29	further	far	ADV
ajst-17938	112	30	studied	study	VERB
ajst-17938	112	31	and	and	CCONJ
ajst-17938	112	32	resolved	resolve	VERB
ajst-17938	112	33	.	.	PUNCT
ajst-17938	113	1	first	first	ADV
ajst-17938	113	2	,	,	PUNCT
ajst-17938	113	3	the	the	DET
ajst-17938	113	4	structure	structure	NOUN
ajst-17938	113	5	and	and	CCONJ
ajst-17938	113	6	activities	activity	NOUN
ajst-17938	113	7	of	of	ADP
ajst-17938	113	8	these	these	DET
ajst-17938	113	9	compounds	compound	NOUN
ajst-17938	113	10	need	need	VERB
ajst-17938	113	11	to	to	PART
ajst-17938	113	12	be	be	AUX
ajst-17938	113	13	further	far	ADV
ajst-17938	113	14	optimized	optimize	VERB
ajst-17938	113	15	to	to	PART
ajst-17938	113	16	improve	improve	VERB
ajst-17938	113	17	their	their	PRON
ajst-17938	113	18	anti	anti	ADJ
ajst-17938	113	19	-	-	ADJ
ajst-17938	113	20	transfer	transfer	ADJ
ajst-17938	113	21	efficacy	efficacy	NOUN
ajst-17938	113	22	and	and	CCONJ
ajst-17938	113	23	selectivity	selectivity	NOUN
ajst-17938	113	24	.	.	PUNCT
ajst-17938	114	1	second	second	ADJ
ajst-17938	114	2	,	,	PUNCT
ajst-17938	114	3	the	the	DET
ajst-17938	114	4	pharmacokinetics	pharmacokinetic	NOUN
ajst-17938	114	5	and	and	CCONJ
ajst-17938	114	6	toxicity	toxicity	NOUN
ajst-17938	114	7	of	of	ADP
ajst-17938	114	8	these	these	DET
ajst-17938	114	9	compounds	compound	NOUN
ajst-17938	114	10	need	need	VERB
ajst-17938	114	11	to	to	PART
ajst-17938	114	12	be	be	AUX
ajst-17938	114	13	further	far	ADV
ajst-17938	114	14	evaluated	evaluate	VERB
ajst-17938	114	15	to	to	PART
ajst-17938	114	16	ensure	ensure	VERB
ajst-17938	114	17	their	their	PRON
ajst-17938	114	18	safety	safety	NOUN
ajst-17938	114	19	and	and	CCONJ
ajst-17938	114	20	efficacy	efficacy	NOUN
ajst-17938	114	21	in	in	ADP
ajst-17938	114	22	clinical	clinical	ADJ
ajst-17938	114	23	applications	application	NOUN
ajst-17938	114	24	.	.	PUNCT
ajst-17938	115	1	moreover	moreover	ADV
ajst-17938	115	2	,	,	PUNCT
ajst-17938	115	3	the	the	DET
ajst-17938	115	4	mechanism	mechanism	NOUN
ajst-17938	115	5	of	of	ADP
ajst-17938	115	6	action	action	NOUN
ajst-17938	115	7	of	of	ADP
ajst-17938	115	8	these	these	DET
ajst-17938	115	9	compounds	compound	NOUN
ajst-17938	115	10	also	also	ADV
ajst-17938	115	11	needs	need	VERB
ajst-17938	115	12	further	far	ADV
ajst-17938	115	13	intensive	intensive	ADJ
ajst-17938	115	14	investigation	investigation	NOUN
ajst-17938	115	15	to	to	PART
ajst-17938	115	16	better	well	ADV
ajst-17938	115	17	understand	understand	VERB
ajst-17938	115	18	their	their	PRON
ajst-17938	115	19	role	role	NOUN
ajst-17938	115	20	in	in	ADP
ajst-17938	115	21	the	the	DET
ajst-17938	115	22	treatment	treatment	NOUN
ajst-17938	115	23	of	of	ADP
ajst-17938	115	24	hcc	hcc	PROPN
ajst-17938	115	25	.	.	PUNCT
ajst-17938	116	1	in	in	ADP
ajst-17938	116	2	the	the	DET
ajst-17938	116	3	future	future	NOUN
ajst-17938	116	4	,	,	PUNCT
ajst-17938	116	5	we	we	PRON
ajst-17938	116	6	will	will	AUX
ajst-17938	116	7	continue	continue	VERB
ajst-17938	116	8	to	to	PART
ajst-17938	116	9	optimize	optimize	VERB
ajst-17938	116	10	the	the	DET
ajst-17938	116	11	structure	structure	NOUN
ajst-17938	116	12	and	and	CCONJ
ajst-17938	116	13	activity	activity	NOUN
ajst-17938	116	14	of	of	ADP
ajst-17938	116	15	these	these	DET
ajst-17938	116	16	compounds	compound	NOUN
ajst-17938	116	17	and	and	CCONJ
ajst-17938	116	18	conduct	conduct	VERB
ajst-17938	116	19	clinical	clinical	ADJ
ajst-17938	116	20	trials	trial	NOUN
ajst-17938	116	21	to	to	PART
ajst-17938	116	22	validate	validate	VERB
ajst-17938	116	23	their	their	PRON
ajst-17938	116	24	efficacy	efficacy	NOUN
ajst-17938	116	25	and	and	CCONJ
ajst-17938	116	26	safety	safety	NOUN
ajst-17938	116	27	.	.	PUNCT
ajst-17938	117	1	in	in	ADP
ajst-17938	117	2	addition	addition	NOUN
ajst-17938	117	3	,	,	PUNCT
ajst-17938	117	4	we	we	PRON
ajst-17938	117	5	will	will	AUX
ajst-17938	117	6	further	far	ADV
ajst-17938	117	7	explore	explore	VERB
ajst-17938	117	8	the	the	DET
ajst-17938	117	9	mechanisms	mechanism	NOUN
ajst-17938	117	10	of	of	ADP
ajst-17938	117	11	these	these	DET
ajst-17938	117	12	compounds	compound	NOUN
ajst-17938	117	13	in	in	ADP
ajst-17938	117	14	order	order	NOUN
ajst-17938	117	15	to	to	PART
ajst-17938	117	16	provide	provide	VERB
ajst-17938	117	17	new	new	ADJ
ajst-17938	117	18	strategies	strategy	NOUN
ajst-17938	117	19	for	for	ADP
ajst-17938	117	20	the	the	DET
ajst-17938	117	21	prevention	prevention	NOUN
ajst-17938	117	22	and	and	CCONJ
ajst-17938	117	23	treatment	treatment	NOUN
ajst-17938	117	24	of	of	ADP
ajst-17938	117	25	hcc	hcc	PROPN
ajst-17938	117	26	.	.	PUNCT
ajst-17938	118	1	through	through	ADP
ajst-17938	118	2	these	these	DET
ajst-17938	118	3	studies	study	NOUN
ajst-17938	118	4	,	,	PUNCT
ajst-17938	118	5	we	we	PRON
ajst-17938	118	6	hope	hope	VERB
ajst-17938	118	7	to	to	PART
ajst-17938	118	8	provide	provide	VERB
ajst-17938	118	9	a	a	DET
ajst-17938	118	10	more	more	ADV
ajst-17938	118	11	effective	effective	ADJ
ajst-17938	118	12	treatment	treatment	NOUN
ajst-17938	118	13	for	for	ADP
ajst-17938	118	14	hcc	hcc	PROPN
ajst-17938	118	15	patients	patient	NOUN
ajst-17938	118	16	,	,	PUNCT
ajst-17938	118	17	improve	improve	VERB
ajst-17938	118	18	their	their	PRON
ajst-17938	118	19	survival	survival	NOUN
ajst-17938	118	20	rate	rate	NOUN
ajst-17938	118	21	and	and	CCONJ
ajst-17938	118	22	improve	improve	VERB
ajst-17938	118	23	their	their	PRON
ajst-17938	118	24	prognosis[8	prognosis[8	NOUN
ajst-17938	118	25	]	]	NOUN
ajst-17938	118	26	.	.	PUNCT
ajst-17938	119	1	6	6	X
ajst-17938	119	2	.	.	X
ajst-17938	119	3	deficiencies	deficiency	NOUN
ajst-17938	119	4	and	and	CCONJ
ajst-17938	119	5	prospects	prospect	NOUN
ajst-17938	119	6	although	although	SCONJ
ajst-17938	119	7	the	the	DET
ajst-17938	119	8	antimetastatic	antimetastatic	ADJ
ajst-17938	119	9	drugs	drug	NOUN
ajst-17938	119	10	based	base	VERB
ajst-17938	119	11	on	on	ADP
ajst-17938	119	12	imides	imide	NOUN
ajst-17938	119	13	polyamine	polyamine	NOUN
ajst-17938	119	14	conjugates	conjugate	NOUN
ajst-17938	119	15	have	have	AUX
ajst-17938	119	16	shown	show	VERB
ajst-17938	119	17	some	some	DET
ajst-17938	119	18	potential	potential	NOUN
ajst-17938	119	19	and	and	CCONJ
ajst-17938	119	20	prospects	prospect	NOUN
ajst-17938	119	21	in	in	ADP
ajst-17938	119	22	the	the	DET
ajst-17938	119	23	treatment	treatment	NOUN
ajst-17938	119	24	of	of	ADP
ajst-17938	119	25	liver	liver	NOUN
ajst-17938	119	26	cancer	cancer	NOUN
ajst-17938	119	27	,	,	PUNCT
ajst-17938	119	28	there	there	PRON
ajst-17938	119	29	are	be	VERB
ajst-17938	119	30	still	still	ADV
ajst-17938	119	31	some	some	DET
ajst-17938	119	32	deficiencies	deficiency	NOUN
ajst-17938	119	33	in	in	ADP
ajst-17938	119	34	the	the	DET
ajst-17938	119	35	current	current	ADJ
ajst-17938	119	36	research	research	NOUN
ajst-17938	119	37	,	,	PUNCT
ajst-17938	119	38	as	as	ADV
ajst-17938	119	39	well	well	ADV
ajst-17938	119	40	as	as	ADP
ajst-17938	119	41	some	some	DET
ajst-17938	119	42	prospects	prospect	NOUN
ajst-17938	119	43	and	and	CCONJ
ajst-17938	119	44	future	future	ADJ
ajst-17938	119	45	research	research	NOUN
ajst-17938	119	46	directions	direction	NOUN
ajst-17938	119	47	.	.	PUNCT
ajst-17938	120	1	first	first	ADV
ajst-17938	120	2	of	of	ADP
ajst-17938	120	3	all	all	PRON
ajst-17938	120	4	,	,	PUNCT
ajst-17938	120	5	the	the	DET
ajst-17938	120	6	current	current	ADJ
ajst-17938	120	7	research	research	NOUN
ajst-17938	120	8	is	be	AUX
ajst-17938	120	9	mainly	mainly	ADV
ajst-17938	120	10	focused	focus	VERB
ajst-17938	120	11	on	on	ADP
ajst-17938	120	12	the	the	DET
ajst-17938	120	13	cell	cell	NOUN
ajst-17938	120	14	level	level	NOUN
ajst-17938	120	15	and	and	CCONJ
ajst-17938	120	16	animal	animal	NOUN
ajst-17938	120	17	models	model	NOUN
ajst-17938	120	18	,	,	PUNCT
ajst-17938	120	19	lacking	lack	VERB
ajst-17938	120	20	the	the	DET
ajst-17938	120	21	validation	validation	NOUN
ajst-17938	120	22	of	of	ADP
ajst-17938	120	23	clinical	clinical	ADJ
ajst-17938	120	24	trials	trial	NOUN
ajst-17938	120	25	.	.	PUNCT
ajst-17938	121	1	although	although	SCONJ
ajst-17938	121	2	the	the	DET
ajst-17938	121	3	anti	anti	ADJ
ajst-17938	121	4	metastatic	metastatic	ADJ
ajst-17938	121	5	effects	effect	NOUN
ajst-17938	121	6	of	of	ADP
ajst-17938	121	7	these	these	DET
ajst-17938	121	8	compounds	compound	NOUN
ajst-17938	121	9	have	have	AUX
ajst-17938	121	10	been	be	AUX
ajst-17938	121	11	confirmed	confirm	VERB
ajst-17938	121	12	in	in	ADP
ajst-17938	121	13	cell	cell	NOUN
ajst-17938	121	14	experiments	experiment	NOUN
ajst-17938	121	15	and	and	CCONJ
ajst-17938	121	16	animal	animal	NOUN
ajst-17938	121	17	models	model	NOUN
ajst-17938	121	18	,	,	PUNCT
ajst-17938	121	19	the	the	DET
ajst-17938	121	20	efficacy	efficacy	NOUN
ajst-17938	121	21	and	and	CCONJ
ajst-17938	121	22	safety	safety	NOUN
ajst-17938	121	23	in	in	ADP
ajst-17938	121	24	humans	human	NOUN
ajst-17938	121	25	still	still	ADV
ajst-17938	121	26	need	need	VERB
ajst-17938	121	27	to	to	PART
ajst-17938	121	28	be	be	AUX
ajst-17938	121	29	further	far	ADV
ajst-17938	121	30	verified	verify	VERB
ajst-17938	121	31	by	by	ADP
ajst-17938	121	32	clinical	clinical	ADJ
ajst-17938	121	33	trials	trial	NOUN
ajst-17938	121	34	.	.	PUNCT
ajst-17938	122	1	therefore	therefore	ADV
ajst-17938	122	2	,	,	PUNCT
ajst-17938	122	3	future	future	ADJ
ajst-17938	122	4	research	research	NOUN
ajst-17938	122	5	needs	need	VERB
ajst-17938	122	6	more	more	ADV
ajst-17938	122	7	clinical	clinical	ADJ
ajst-17938	122	8	trials	trial	NOUN
ajst-17938	122	9	to	to	PART
ajst-17938	122	10	evaluate	evaluate	VERB
ajst-17938	122	11	the	the	DET
ajst-17938	122	12	clinical	clinical	ADJ
ajst-17938	122	13	application	application	NOUN
ajst-17938	122	14	value	value	NOUN
ajst-17938	122	15	of	of	ADP
ajst-17938	122	16	these	these	DET
ajst-17938	122	17	compounds	compound	NOUN
ajst-17938	122	18	.	.	PUNCT
ajst-17938	123	1	secondly	secondly	ADV
ajst-17938	123	2	,	,	PUNCT
ajst-17938	123	3	the	the	DET
ajst-17938	123	4	current	current	ADJ
ajst-17938	123	5	research	research	NOUN
ajst-17938	123	6	mainly	mainly	ADV
ajst-17938	123	7	focuses	focus	VERB
ajst-17938	123	8	on	on	ADP
ajst-17938	123	9	the	the	DET
ajst-17938	123	10	anti	anti	ADJ
ajst-17938	123	11	metastatic	metastatic	ADJ
ajst-17938	123	12	treatment	treatment	NOUN
ajst-17938	123	13	of	of	ADP
ajst-17938	123	14	liver	liver	NOUN
ajst-17938	123	15	cancer	cancer	NOUN
ajst-17938	123	16	,	,	PUNCT
ajst-17938	123	17	while	while	SCONJ
ajst-17938	123	18	for	for	ADP
ajst-17938	123	19	other	other	ADJ
ajst-17938	123	20	treatment	treatment	NOUN
ajst-17938	123	21	strategies	strategy	NOUN
ajst-17938	123	22	of	of	ADP
ajst-17938	123	23	liver	liver	NOUN
ajst-17938	123	24	cancer	cancer	NOUN
ajst-17938	123	25	,	,	PUNCT
ajst-17938	123	26	such	such	ADJ
ajst-17938	123	27	as	as	ADP
ajst-17938	123	28	surgical	surgical	ADJ
ajst-17938	123	29	resection	resection	NOUN
ajst-17938	123	30	,	,	PUNCT
ajst-17938	123	31	chemotherapy	chemotherapy	NOUN
ajst-17938	123	32	,	,	PUNCT
ajst-17938	123	33	radiotherapy	radiotherapy	NOUN
ajst-17938	123	34	and	and	CCONJ
ajst-17938	123	35	targeted	target	VERB
ajst-17938	123	36	therapy	therapy	NOUN
ajst-17938	123	37	,	,	PUNCT
ajst-17938	123	38	the	the	DET
ajst-17938	123	39	synergistic	synergistic	ADJ
ajst-17938	123	40	effect	effect	NOUN
ajst-17938	123	41	and	and	CCONJ
ajst-17938	123	42	optimization	optimization	NOUN
ajst-17938	123	43	scheme	scheme	NOUN
ajst-17938	123	44	of	of	ADP
ajst-17938	123	45	these	these	DET
ajst-17938	123	46	compounds	compound	NOUN
ajst-17938	123	47	have	have	AUX
ajst-17938	123	48	not	not	PART
ajst-17938	123	49	been	be	AUX
ajst-17938	123	50	fully	fully	ADV
ajst-17938	123	51	studied	study	VERB
ajst-17938	123	52	.	.	PUNCT
ajst-17938	124	1	therefore	therefore	ADV
ajst-17938	124	2	,	,	PUNCT
ajst-17938	124	3	future	future	ADJ
ajst-17938	124	4	studies	study	NOUN
ajst-17938	124	5	need	need	VERB
ajst-17938	124	6	to	to	PART
ajst-17938	124	7	explore	explore	VERB
ajst-17938	124	8	the	the	DET
ajst-17938	124	9	combination	combination	NOUN
ajst-17938	124	10	of	of	ADP
ajst-17938	124	11	these	these	DET
ajst-17938	124	12	compounds	compound	NOUN
ajst-17938	124	13	with	with	ADP
ajst-17938	124	14	other	other	ADJ
ajst-17938	124	15	therapeutic	therapeutic	ADJ
ajst-17938	124	16	strategies	strategy	NOUN
ajst-17938	124	17	in	in	ADP
ajst-17938	124	18	order	order	NOUN
ajst-17938	124	19	to	to	PART
ajst-17938	124	20	improve	improve	VERB
ajst-17938	124	21	the	the	DET
ajst-17938	124	22	264	264	NUM
ajst-17938	124	23	overall	overall	ADJ
ajst-17938	124	24	therapeutic	therapeutic	ADJ
ajst-17938	124	25	effect	effect	NOUN
ajst-17938	124	26	of	of	ADP
ajst-17938	124	27	liver	liver	NOUN
ajst-17938	124	28	cancer	cancer	NOUN
ajst-17938	124	29	.	.	PUNCT
ajst-17938	125	1	in	in	ADP
ajst-17938	125	2	addition	addition	NOUN
ajst-17938	125	3	,	,	PUNCT
ajst-17938	125	4	the	the	DET
ajst-17938	125	5	current	current	ADJ
ajst-17938	125	6	study	study	NOUN
ajst-17938	125	7	is	be	AUX
ajst-17938	125	8	still	still	ADV
ajst-17938	125	9	not	not	PART
ajst-17938	125	10	clear	clear	ADJ
ajst-17938	125	11	and	and	CCONJ
ajst-17938	125	12	comprehensive	comprehensive	ADJ
ajst-17938	125	13	about	about	ADP
ajst-17938	125	14	the	the	DET
ajst-17938	125	15	mechanism	mechanism	NOUN
ajst-17938	125	16	of	of	ADP
ajst-17938	125	17	action	action	NOUN
ajst-17938	125	18	of	of	ADP
ajst-17938	125	19	imides	imide	NOUN
ajst-17938	125	20	polyamine	polyamine	NOUN
ajst-17938	125	21	conjugates	conjugate	NOUN
ajst-17938	125	22	.	.	PUNCT
ajst-17938	126	1	although	although	SCONJ
ajst-17938	126	2	these	these	DET
ajst-17938	126	3	compounds	compound	NOUN
ajst-17938	126	4	have	have	AUX
ajst-17938	126	5	been	be	AUX
ajst-17938	126	6	found	find	VERB
ajst-17938	126	7	to	to	PART
ajst-17938	126	8	inhibit	inhibit	VERB
ajst-17938	126	9	the	the	DET
ajst-17938	126	10	metastasis	metastasis	NOUN
ajst-17938	126	11	of	of	ADP
ajst-17938	126	12	liver	liver	NOUN
ajst-17938	126	13	cancer	cancer	NOUN
ajst-17938	126	14	cells	cell	NOUN
ajst-17938	126	15	through	through	ADP
ajst-17938	126	16	a	a	DET
ajst-17938	126	17	variety	variety	NOUN
ajst-17938	126	18	of	of	ADP
ajst-17938	126	19	mechanisms	mechanism	NOUN
ajst-17938	126	20	,	,	PUNCT
ajst-17938	126	21	the	the	DET
ajst-17938	126	22	specific	specific	ADJ
ajst-17938	126	23	molecular	molecular	ADJ
ajst-17938	126	24	mechanisms	mechanism	NOUN
ajst-17938	126	25	and	and	CCONJ
ajst-17938	126	26	signaling	signal	VERB
ajst-17938	126	27	pathways	pathway	NOUN
ajst-17938	126	28	still	still	ADV
ajst-17938	126	29	need	need	VERB
ajst-17938	126	30	further	further	ADJ
ajst-17938	126	31	study	study	NOUN
ajst-17938	126	32	.	.	PUNCT
ajst-17938	127	1	therefore	therefore	ADV
ajst-17938	127	2	,	,	PUNCT
ajst-17938	127	3	future	future	ADJ
ajst-17938	127	4	studies	study	NOUN
ajst-17938	127	5	need	need	VERB
ajst-17938	127	6	to	to	PART
ajst-17938	127	7	explore	explore	VERB
ajst-17938	127	8	the	the	DET
ajst-17938	127	9	molecular	molecular	ADJ
ajst-17938	127	10	mechanisms	mechanism	NOUN
ajst-17938	127	11	and	and	CCONJ
ajst-17938	127	12	signaling	signal	VERB
ajst-17938	127	13	pathways	pathway	NOUN
ajst-17938	127	14	of	of	ADP
ajst-17938	127	15	these	these	DET
ajst-17938	127	16	compounds	compound	NOUN
ajst-17938	127	17	in	in	SCONJ
ajst-17938	127	18	order	order	NOUN
ajst-17938	127	19	to	to	PART
ajst-17938	127	20	more	more	ADV
ajst-17938	127	21	accurately	accurately	ADV
ajst-17938	127	22	understand	understand	VERB
ajst-17938	127	23	their	their	PRON
ajst-17938	127	24	roles	role	NOUN
ajst-17938	127	25	in	in	ADP
ajst-17938	127	26	the	the	DET
ajst-17938	127	27	treatment	treatment	NOUN
ajst-17938	127	28	of	of	ADP
ajst-17938	127	29	liver	liver	NOUN
ajst-17938	127	30	cancer	cancer	NOUN
ajst-17938	127	31	.	.	PUNCT
ajst-17938	128	1	finally	finally	ADV
ajst-17938	128	2	,	,	PUNCT
ajst-17938	128	3	although	although	SCONJ
ajst-17938	128	4	imides	imide	NOUN
ajst-17938	128	5	polyamine	polyamine	NOUN
ajst-17938	128	6	conjugates	conjugate	NOUN
ajst-17938	128	7	have	have	AUX
ajst-17938	128	8	shown	show	VERB
ajst-17938	128	9	some	some	DET
ajst-17938	128	10	potential	potential	NOUN
ajst-17938	128	11	and	and	CCONJ
ajst-17938	128	12	prospects	prospect	NOUN
ajst-17938	128	13	in	in	ADP
ajst-17938	128	14	the	the	DET
ajst-17938	128	15	treatment	treatment	NOUN
ajst-17938	128	16	of	of	ADP
ajst-17938	128	17	liver	liver	NOUN
ajst-17938	128	18	cancer	cancer	NOUN
ajst-17938	128	19	,	,	PUNCT
ajst-17938	128	20	the	the	DET
ajst-17938	128	21	current	current	ADJ
ajst-17938	128	22	research	research	NOUN
ajst-17938	128	23	is	be	AUX
ajst-17938	128	24	still	still	ADV
ajst-17938	128	25	in	in	ADP
ajst-17938	128	26	the	the	DET
ajst-17938	128	27	preliminary	preliminary	ADJ
ajst-17938	128	28	stage	stage	NOUN
ajst-17938	128	29	,	,	PUNCT
ajst-17938	128	30	and	and	CCONJ
ajst-17938	128	31	more	more	ADJ
ajst-17938	128	32	studies	study	NOUN
ajst-17938	128	33	are	be	AUX
ajst-17938	128	34	needed	need	VERB
ajst-17938	128	35	to	to	PART
ajst-17938	128	36	verify	verify	VERB
ajst-17938	128	37	its	its	PRON
ajst-17938	128	38	efficacy	efficacy	NOUN
ajst-17938	128	39	and	and	CCONJ
ajst-17938	128	40	safety	safety	NOUN
ajst-17938	128	41	.	.	PUNCT
ajst-17938	129	1	therefore	therefore	ADV
ajst-17938	129	2	,	,	PUNCT
ajst-17938	129	3	future	future	ADJ
ajst-17938	129	4	research	research	NOUN
ajst-17938	129	5	needs	need	VERB
ajst-17938	129	6	more	more	ADJ
ajst-17938	129	7	laboratory	laboratory	NOUN
ajst-17938	129	8	and	and	CCONJ
ajst-17938	129	9	clinical	clinical	ADJ
ajst-17938	129	10	trial	trial	NOUN
ajst-17938	129	11	studies	study	NOUN
ajst-17938	129	12	to	to	PART
ajst-17938	129	13	further	far	ADV
ajst-17938	129	14	verify	verify	VERB
ajst-17938	129	15	the	the	DET
ajst-17938	129	16	application	application	NOUN
ajst-17938	129	17	prospects	prospect	NOUN
ajst-17938	129	18	of	of	ADP
ajst-17938	129	19	these	these	DET
ajst-17938	129	20	compounds	compound	NOUN
ajst-17938	129	21	.	.	PUNCT
ajst-17938	130	1	in	in	ADP
ajst-17938	130	2	conclusion	conclusion	NOUN
ajst-17938	130	3	,	,	PUNCT
ajst-17938	130	4	anti	anti	X
ajst-17938	130	5	metastatic	metastatic	ADJ
ajst-17938	130	6	drugs	drug	NOUN
ajst-17938	130	7	based	base	VERB
ajst-17938	130	8	on	on	ADP
ajst-17938	130	9	imides	imide	NOUN
ajst-17938	130	10	polyamine	polyamine	NOUN
ajst-17938	130	11	conjugates	conjugate	NOUN
ajst-17938	130	12	have	have	VERB
ajst-17938	130	13	certain	certain	ADJ
ajst-17938	130	14	potential	potential	NOUN
ajst-17938	130	15	and	and	CCONJ
ajst-17938	130	16	prospects	prospect	NOUN
ajst-17938	130	17	in	in	ADP
ajst-17938	130	18	the	the	DET
ajst-17938	130	19	treatment	treatment	NOUN
ajst-17938	130	20	of	of	ADP
ajst-17938	130	21	liver	liver	NOUN
ajst-17938	130	22	cancer	cancer	NOUN
ajst-17938	130	23	,	,	PUNCT
ajst-17938	130	24	but	but	CCONJ
ajst-17938	130	25	there	there	PRON
ajst-17938	130	26	are	be	VERB
ajst-17938	130	27	still	still	ADV
ajst-17938	130	28	some	some	DET
ajst-17938	130	29	shortcomings	shortcoming	NOUN
ajst-17938	130	30	and	and	CCONJ
ajst-17938	130	31	future	future	ADJ
ajst-17938	130	32	research	research	NOUN
ajst-17938	130	33	directions	direction	NOUN
ajst-17938	130	34	.	.	PUNCT
ajst-17938	131	1	through	through	ADP
ajst-17938	131	2	further	further	ADJ
ajst-17938	131	3	research	research	NOUN
ajst-17938	131	4	and	and	CCONJ
ajst-17938	131	5	clinical	clinical	ADJ
ajst-17938	131	6	trials	trial	NOUN
ajst-17938	131	7	,	,	PUNCT
ajst-17938	131	8	it	it	PRON
ajst-17938	131	9	is	be	AUX
ajst-17938	131	10	expected	expect	VERB
ajst-17938	131	11	to	to	PART
ajst-17938	131	12	provide	provide	VERB
ajst-17938	131	13	new	new	ADJ
ajst-17938	131	14	strategies	strategy	NOUN
ajst-17938	131	15	and	and	CCONJ
ajst-17938	131	16	methods	method	NOUN
ajst-17938	131	17	for	for	ADP
ajst-17938	131	18	the	the	DET
ajst-17938	131	19	prevention	prevention	NOUN
ajst-17938	131	20	and	and	CCONJ
ajst-17938	131	21	treatment	treatment	NOUN
ajst-17938	131	22	of	of	ADP
ajst-17938	131	23	liver	liver	NOUN
ajst-17938	131	24	cancer	cancer	NOUN
ajst-17938	131	25	,	,	PUNCT
ajst-17938	131	26	bring	bring	VERB
ajst-17938	131	27	more	more	ADV
ajst-17938	131	28	effective	effective	ADJ
ajst-17938	131	29	treatment	treatment	NOUN
ajst-17938	131	30	for	for	ADP
ajst-17938	131	31	patients	patient	NOUN
ajst-17938	131	32	,	,	PUNCT
ajst-17938	131	33	improve	improve	VERB
ajst-17938	131	34	their	their	PRON
ajst-17938	131	35	survival	survival	NOUN
ajst-17938	131	36	rate	rate	NOUN
ajst-17938	131	37	and	and	CCONJ
ajst-17938	131	38	prognosis[9]-[12	prognosis[9]-[12	NOUN
ajst-17938	131	39	]	]	X
ajst-17938	131	40	.	.	PUNCT
ajst-17938	132	1	7	7	X
ajst-17938	132	2	.	.	X
ajst-17938	132	3	deficiencies	deficiency	NOUN
ajst-17938	132	4	and	and	CCONJ
ajst-17938	132	5	prospects	prospect	NOUN
ajst-17938	132	6	this	this	DET
ajst-17938	132	7	study	study	NOUN
ajst-17938	132	8	is	be	AUX
ajst-17938	132	9	based	base	VERB
ajst-17938	132	10	on	on	ADP
ajst-17938	132	11	the	the	DET
ajst-17938	132	12	development	development	NOUN
ajst-17938	132	13	of	of	ADP
ajst-17938	132	14	anti	anti	ADJ
ajst-17938	132	15	metastatic	metastatic	ADJ
ajst-17938	132	16	drugs	drug	NOUN
ajst-17938	132	17	of	of	ADP
ajst-17938	132	18	imides	imide	NOUN
ajst-17938	132	19	polyamine	polyamine	NOUN
ajst-17938	132	20	conjugates	conjugate	NOUN
ajst-17938	132	21	and	and	CCONJ
ajst-17938	132	22	their	their	PRON
ajst-17938	132	23	application	application	NOUN
ajst-17938	132	24	in	in	ADP
ajst-17938	132	25	the	the	DET
ajst-17938	132	26	treatment	treatment	NOUN
ajst-17938	132	27	of	of	ADP
ajst-17938	132	28	liver	liver	NOUN
ajst-17938	132	29	cancer	cancer	NOUN
ajst-17938	132	30	,	,	PUNCT
ajst-17938	132	31	and	and	CCONJ
ajst-17938	132	32	has	have	AUX
ajst-17938	132	33	achieved	achieve	VERB
ajst-17938	132	34	some	some	DET
ajst-17938	132	35	results	result	NOUN
ajst-17938	132	36	.	.	PUNCT
ajst-17938	133	1	however	however	ADV
ajst-17938	133	2	,	,	PUNCT
ajst-17938	133	3	some	some	DET
ajst-17938	133	4	deficiencies	deficiency	NOUN
ajst-17938	133	5	were	be	AUX
ajst-17938	133	6	also	also	ADV
ajst-17938	133	7	found	find	VERB
ajst-17938	133	8	in	in	ADP
ajst-17938	133	9	the	the	DET
ajst-17938	133	10	research	research	NOUN
ajst-17938	133	11	process	process	NOUN
ajst-17938	133	12	,	,	PUNCT
ajst-17938	133	13	and	and	CCONJ
ajst-17938	133	14	the	the	DET
ajst-17938	133	15	future	future	ADJ
ajst-17938	133	16	research	research	NOUN
ajst-17938	133	17	directions	direction	NOUN
ajst-17938	133	18	were	be	AUX
ajst-17938	133	19	also	also	ADV
ajst-17938	133	20	prospected	prospect	VERB
ajst-17938	133	21	.	.	PUNCT
ajst-17938	134	1	first	first	ADV
ajst-17938	134	2	,	,	PUNCT
ajst-17938	134	3	the	the	DET
ajst-17938	134	4	sample	sample	NOUN
ajst-17938	134	5	size	size	NOUN
ajst-17938	134	6	of	of	ADP
ajst-17938	134	7	this	this	DET
ajst-17938	134	8	study	study	NOUN
ajst-17938	134	9	is	be	AUX
ajst-17938	134	10	small	small	ADJ
ajst-17938	134	11	,	,	PUNCT
ajst-17938	134	12	which	which	PRON
ajst-17938	134	13	may	may	AUX
ajst-17938	134	14	affect	affect	VERB
ajst-17938	134	15	the	the	DET
ajst-17938	134	16	reliability	reliability	NOUN
ajst-17938	134	17	and	and	CCONJ
ajst-17938	134	18	generalizability	generalizability	NOUN
ajst-17938	134	19	of	of	ADP
ajst-17938	134	20	the	the	DET
ajst-17938	134	21	research	research	NOUN
ajst-17938	134	22	results	result	NOUN
ajst-17938	134	23	.	.	PUNCT
ajst-17938	135	1	therefore	therefore	ADV
ajst-17938	135	2	,	,	PUNCT
ajst-17938	135	3	in	in	ADP
ajst-17938	135	4	future	future	ADJ
ajst-17938	135	5	studies	study	NOUN
ajst-17938	135	6	,	,	PUNCT
ajst-17938	135	7	the	the	DET
ajst-17938	135	8	sample	sample	NOUN
ajst-17938	135	9	size	size	NOUN
ajst-17938	135	10	needs	need	VERB
ajst-17938	135	11	to	to	PART
ajst-17938	135	12	be	be	AUX
ajst-17938	135	13	expanded	expand	VERB
ajst-17938	135	14	in	in	ADP
ajst-17938	135	15	order	order	NOUN
ajst-17938	135	16	to	to	PART
ajst-17938	135	17	more	more	ADV
ajst-17938	135	18	accurately	accurately	ADV
ajst-17938	135	19	evaluate	evaluate	VERB
ajst-17938	135	20	the	the	DET
ajst-17938	135	21	effect	effect	NOUN
ajst-17938	135	22	of	of	ADP
ajst-17938	135	23	imides	imide	NOUN
ajst-17938	135	24	polyamine	polyamine	NOUN
ajst-17938	135	25	conjugates	conjugate	NOUN
ajst-17938	135	26	in	in	ADP
ajst-17938	135	27	the	the	DET
ajst-17938	135	28	treatment	treatment	NOUN
ajst-17938	135	29	of	of	ADP
ajst-17938	135	30	liver	liver	NOUN
ajst-17938	135	31	cancer	cancer	NOUN
ajst-17938	135	32	.	.	PUNCT
ajst-17938	136	1	secondly	secondly	ADV
ajst-17938	136	2	,	,	PUNCT
ajst-17938	136	3	this	this	DET
ajst-17938	136	4	study	study	NOUN
ajst-17938	136	5	mainly	mainly	ADV
ajst-17938	136	6	focused	focus	VERB
ajst-17938	136	7	on	on	ADP
ajst-17938	136	8	the	the	DET
ajst-17938	136	9	application	application	NOUN
ajst-17938	136	10	of	of	ADP
ajst-17938	136	11	imides	imide	NOUN
ajst-17938	136	12	polyamine	polyamine	NOUN
ajst-17938	136	13	conjugates	conjugate	NOUN
ajst-17938	136	14	in	in	ADP
ajst-17938	136	15	the	the	DET
ajst-17938	136	16	treatment	treatment	NOUN
ajst-17938	136	17	of	of	ADP
ajst-17938	136	18	liver	liver	NOUN
ajst-17938	136	19	cancer	cancer	NOUN
ajst-17938	136	20	,	,	PUNCT
ajst-17938	136	21	while	while	SCONJ
ajst-17938	136	22	its	its	PRON
ajst-17938	136	23	application	application	NOUN
ajst-17938	136	24	in	in	ADP
ajst-17938	136	25	the	the	DET
ajst-17938	136	26	treatment	treatment	NOUN
ajst-17938	136	27	of	of	ADP
ajst-17938	136	28	other	other	ADJ
ajst-17938	136	29	types	type	NOUN
ajst-17938	136	30	of	of	ADP
ajst-17938	136	31	tumors	tumor	NOUN
ajst-17938	136	32	has	have	AUX
ajst-17938	136	33	not	not	PART
ajst-17938	136	34	been	be	AUX
ajst-17938	136	35	further	far	ADV
ajst-17938	136	36	studied	study	VERB
ajst-17938	136	37	.	.	PUNCT
ajst-17938	137	1	therefore	therefore	ADV
ajst-17938	137	2	,	,	PUNCT
ajst-17938	137	3	future	future	ADJ
ajst-17938	137	4	research	research	NOUN
ajst-17938	137	5	can	can	AUX
ajst-17938	137	6	explore	explore	VERB
ajst-17938	137	7	the	the	DET
ajst-17938	137	8	application	application	NOUN
ajst-17938	137	9	of	of	ADP
ajst-17938	137	10	imides	imide	NOUN
ajst-17938	137	11	polyamine	polyamine	NOUN
ajst-17938	137	12	conjugates	conjugate	NOUN
ajst-17938	137	13	in	in	ADP
ajst-17938	137	14	the	the	DET
ajst-17938	137	15	treatment	treatment	NOUN
ajst-17938	137	16	of	of	ADP
ajst-17938	137	17	other	other	ADJ
ajst-17938	137	18	types	type	NOUN
ajst-17938	137	19	of	of	ADP
ajst-17938	137	20	tumors	tumor	NOUN
ajst-17938	137	21	,	,	PUNCT
ajst-17938	137	22	in	in	ADP
ajst-17938	137	23	order	order	NOUN
ajst-17938	137	24	to	to	PART
ajst-17938	137	25	expand	expand	VERB
ajst-17938	137	26	its	its	PRON
ajst-17938	137	27	scope	scope	NOUN
ajst-17938	137	28	of	of	ADP
ajst-17938	137	29	application	application	NOUN
ajst-17938	137	30	.	.	PUNCT
ajst-17938	138	1	in	in	ADP
ajst-17938	138	2	addition	addition	NOUN
ajst-17938	138	3	,	,	PUNCT
ajst-17938	138	4	this	this	DET
ajst-17938	138	5	study	study	NOUN
ajst-17938	138	6	mainly	mainly	ADV
ajst-17938	138	7	evaluated	evaluate	VERB
ajst-17938	138	8	the	the	DET
ajst-17938	138	9	antimetastatic	antimetastatic	ADJ
ajst-17938	138	10	effect	effect	NOUN
ajst-17938	138	11	of	of	ADP
ajst-17938	138	12	imides	imide	NOUN
ajst-17938	138	13	polyamine	polyamine	NOUN
ajst-17938	138	14	conjugates	conjugate	NOUN
ajst-17938	138	15	through	through	ADP
ajst-17938	138	16	cell	cell	NOUN
ajst-17938	138	17	experiments	experiment	NOUN
ajst-17938	138	18	and	and	CCONJ
ajst-17938	138	19	animal	animal	NOUN
ajst-17938	138	20	models	model	NOUN
ajst-17938	138	21	,	,	PUNCT
ajst-17938	138	22	lacking	lack	VERB
ajst-17938	138	23	the	the	DET
ajst-17938	138	24	validation	validation	NOUN
ajst-17938	138	25	of	of	ADP
ajst-17938	138	26	clinical	clinical	ADJ
ajst-17938	138	27	trials	trial	NOUN
ajst-17938	138	28	.	.	PUNCT
ajst-17938	139	1	therefore	therefore	ADV
ajst-17938	139	2	,	,	PUNCT
ajst-17938	139	3	more	more	ADV
ajst-17938	139	4	clinical	clinical	ADJ
ajst-17938	139	5	trials	trial	NOUN
ajst-17938	139	6	are	be	AUX
ajst-17938	139	7	needed	need	VERB
ajst-17938	139	8	for	for	SCONJ
ajst-17938	139	9	future	future	ADJ
ajst-17938	139	10	studies	study	NOUN
ajst-17938	139	11	to	to	PART
ajst-17938	139	12	verify	verify	VERB
ajst-17938	139	13	the	the	DET
ajst-17938	139	14	safety	safety	NOUN
ajst-17938	139	15	and	and	CCONJ
ajst-17938	139	16	efficacy	efficacy	NOUN
ajst-17938	139	17	of	of	ADP
ajst-17938	139	18	imides	imide	NOUN
ajst-17938	139	19	polyamine	polyamine	NOUN
ajst-17938	139	20	conjugates	conjugate	NOUN
ajst-17938	139	21	in	in	ADP
ajst-17938	139	22	the	the	DET
ajst-17938	139	23	treatment	treatment	NOUN
ajst-17938	139	24	of	of	ADP
ajst-17938	139	25	liver	liver	NOUN
ajst-17938	139	26	cancer[12][20	cancer[12][20	PROPN
ajst-17938	139	27	]	]	PUNCT
ajst-17938	139	28	.	.	PUNCT
ajst-17938	140	1	finally	finally	ADV
ajst-17938	140	2	,	,	PUNCT
ajst-17938	140	3	although	although	SCONJ
ajst-17938	140	4	the	the	DET
ajst-17938	140	5	anti	anti	ADJ
ajst-17938	140	6	metastatic	metastatic	ADJ
ajst-17938	140	7	mechanism	mechanism	NOUN
ajst-17938	140	8	of	of	ADP
ajst-17938	140	9	imide	imide	ADJ
ajst-17938	140	10	polyamine	polyamine	NOUN
ajst-17938	140	11	conjugates	conjugate	NOUN
ajst-17938	140	12	has	have	AUX
ajst-17938	140	13	been	be	AUX
ajst-17938	140	14	explored	explore	VERB
ajst-17938	140	15	in	in	ADP
ajst-17938	140	16	this	this	DET
ajst-17938	140	17	study	study	NOUN
ajst-17938	140	18	,	,	PUNCT
ajst-17938	140	19	its	its	PRON
ajst-17938	140	20	specific	specific	ADJ
ajst-17938	140	21	molecular	molecular	ADJ
ajst-17938	140	22	mechanism	mechanism	NOUN
ajst-17938	140	23	and	and	CCONJ
ajst-17938	140	24	signaling	signal	VERB
ajst-17938	140	25	pathway	pathway	NOUN
ajst-17938	140	26	still	still	ADV
ajst-17938	140	27	need	need	VERB
ajst-17938	140	28	further	far	ADV
ajst-17938	140	29	in	in	ADP
ajst-17938	140	30	-	-	PUNCT
ajst-17938	140	31	depth	depth	NOUN
ajst-17938	140	32	study	study	NOUN
ajst-17938	140	33	.	.	PUNCT
ajst-17938	141	1	therefore	therefore	ADV
ajst-17938	141	2	,	,	PUNCT
ajst-17938	141	3	future	future	ADJ
ajst-17938	141	4	studies	study	NOUN
ajst-17938	141	5	need	need	VERB
ajst-17938	141	6	to	to	PART
ajst-17938	141	7	further	far	ADV
ajst-17938	141	8	explore	explore	VERB
ajst-17938	141	9	the	the	DET
ajst-17938	141	10	molecular	molecular	ADJ
ajst-17938	141	11	mechanism	mechanism	NOUN
ajst-17938	141	12	and	and	CCONJ
ajst-17938	141	13	signaling	signal	VERB
ajst-17938	141	14	pathway	pathway	NOUN
ajst-17938	141	15	of	of	ADP
ajst-17938	141	16	imide	imide	ADJ
ajst-17938	141	17	polyamine	polyamine	NOUN
ajst-17938	141	18	conjugates	conjugate	NOUN
ajst-17938	141	19	in	in	SCONJ
ajst-17938	141	20	order	order	NOUN
ajst-17938	141	21	to	to	PART
ajst-17938	141	22	more	more	ADV
ajst-17938	141	23	accurately	accurately	ADV
ajst-17938	141	24	understand	understand	VERB
ajst-17938	141	25	their	their	PRON
ajst-17938	141	26	role	role	NOUN
ajst-17938	141	27	in	in	ADP
ajst-17938	141	28	the	the	DET
ajst-17938	141	29	treatment	treatment	NOUN
ajst-17938	141	30	of	of	ADP
ajst-17938	141	31	liver	liver	NOUN
ajst-17938	141	32	cancer[21	cancer[21	NOUN
ajst-17938	141	33	]	]	PUNCT
ajst-17938	141	34	.	.	PUNCT
ajst-17938	142	1	in	in	ADP
ajst-17938	142	2	conclusion	conclusion	NOUN
ajst-17938	142	3	,	,	PUNCT
ajst-17938	142	4	although	although	SCONJ
ajst-17938	142	5	this	this	DET
ajst-17938	142	6	study	study	NOUN
ajst-17938	142	7	has	have	AUX
ajst-17938	142	8	made	make	VERB
ajst-17938	142	9	some	some	DET
ajst-17938	142	10	achievements	achievement	NOUN
ajst-17938	142	11	in	in	ADP
ajst-17938	142	12	the	the	DET
ajst-17938	142	13	development	development	NOUN
ajst-17938	142	14	of	of	ADP
ajst-17938	142	15	anti	anti	ADJ
ajst-17938	142	16	metastatic	metastatic	ADJ
ajst-17938	142	17	drugs	drug	NOUN
ajst-17938	142	18	based	base	VERB
ajst-17938	142	19	on	on	ADP
ajst-17938	142	20	imides	imide	NOUN
ajst-17938	142	21	polyamine	polyamine	NOUN
ajst-17938	142	22	conjugates	conjugate	NOUN
ajst-17938	142	23	and	and	CCONJ
ajst-17938	142	24	their	their	PRON
ajst-17938	142	25	application	application	NOUN
ajst-17938	142	26	in	in	ADP
ajst-17938	142	27	the	the	DET
ajst-17938	142	28	treatment	treatment	NOUN
ajst-17938	142	29	of	of	ADP
ajst-17938	142	30	liver	liver	NOUN
ajst-17938	142	31	cancer	cancer	NOUN
ajst-17938	142	32	,	,	PUNCT
ajst-17938	142	33	there	there	PRON
ajst-17938	142	34	are	be	VERB
ajst-17938	142	35	still	still	ADV
ajst-17938	142	36	some	some	DET
ajst-17938	142	37	shortcomings	shortcoming	NOUN
ajst-17938	142	38	.	.	PUNCT
ajst-17938	143	1	future	future	ADJ
ajst-17938	143	2	research	research	NOUN
ajst-17938	143	3	needs	need	VERB
ajst-17938	143	4	to	to	PART
ajst-17938	143	5	expand	expand	VERB
ajst-17938	143	6	the	the	DET
ajst-17938	143	7	sample	sample	NOUN
ajst-17938	143	8	size	size	NOUN
ajst-17938	143	9	,	,	PUNCT
ajst-17938	143	10	explore	explore	VERB
ajst-17938	143	11	its	its	PRON
ajst-17938	143	12	application	application	NOUN
ajst-17938	143	13	in	in	ADP
ajst-17938	143	14	the	the	DET
ajst-17938	143	15	treatment	treatment	NOUN
ajst-17938	143	16	of	of	ADP
ajst-17938	143	17	other	other	ADJ
ajst-17938	143	18	types	type	NOUN
ajst-17938	143	19	of	of	ADP
ajst-17938	143	20	tumors	tumor	NOUN
ajst-17938	143	21	,	,	PUNCT
ajst-17938	143	22	verify	verify	VERB
ajst-17938	143	23	clinical	clinical	ADJ
ajst-17938	143	24	trials	trial	NOUN
ajst-17938	143	25	,	,	PUNCT
ajst-17938	143	26	and	and	CCONJ
ajst-17938	143	27	further	far	ADV
ajst-17938	143	28	study	study	VERB
ajst-17938	143	29	its	its	PRON
ajst-17938	143	30	molecular	molecular	ADJ
ajst-17938	143	31	mechanisms	mechanism	NOUN
ajst-17938	143	32	and	and	CCONJ
ajst-17938	143	33	signaling	signal	VERB
ajst-17938	143	34	pathways	pathway	NOUN
ajst-17938	143	35	,	,	PUNCT
ajst-17938	143	36	in	in	ADP
ajst-17938	143	37	order	order	NOUN
ajst-17938	143	38	to	to	PART
ajst-17938	143	39	provide	provide	VERB
ajst-17938	143	40	new	new	ADJ
ajst-17938	143	41	strategies	strategy	NOUN
ajst-17938	143	42	and	and	CCONJ
ajst-17938	143	43	methods	method	NOUN
ajst-17938	143	44	for	for	ADP
ajst-17938	143	45	the	the	DET
ajst-17938	143	46	prevention	prevention	NOUN
ajst-17938	143	47	and	and	CCONJ
ajst-17938	143	48	treatment	treatment	NOUN
ajst-17938	143	49	of	of	ADP
ajst-17938	143	50	liver	liver	NOUN
ajst-17938	143	51	cancer[[16	cancer[[16	NOUN
ajst-17938	143	52	]	]	PUNCT
ajst-17938	143	53	.	.	PUNCT
ajst-17938	144	1	8	8	X
ajst-17938	144	2	.	.	X
ajst-17938	144	3	conclusion	conclusion	NOUN
ajst-17938	144	4	in	in	ADP
ajst-17938	144	5	this	this	DET
ajst-17938	144	6	study	study	NOUN
ajst-17938	144	7	,	,	PUNCT
ajst-17938	144	8	a	a	DET
ajst-17938	144	9	novel	novel	ADJ
ajst-17938	144	10	anti	anti	ADJ
ajst-17938	144	11	metastatic	metastatic	ADJ
ajst-17938	144	12	drug	drug	NOUN
ajst-17938	144	13	was	be	AUX
ajst-17938	144	14	developed	develop	VERB
ajst-17938	144	15	based	base	VERB
ajst-17938	144	16	on	on	ADP
ajst-17938	144	17	imides	imide	NOUN
ajst-17938	144	18	polyamine	polyamine	NOUN
ajst-17938	144	19	conjugates	conjugate	NOUN
ajst-17938	144	20	,	,	PUNCT
ajst-17938	144	21	and	and	CCONJ
ajst-17938	144	22	its	its	PRON
ajst-17938	144	23	application	application	NOUN
ajst-17938	144	24	in	in	ADP
ajst-17938	144	25	the	the	DET
ajst-17938	144	26	treatment	treatment	NOUN
ajst-17938	144	27	of	of	ADP
ajst-17938	144	28	liver	liver	NOUN
ajst-17938	144	29	cancer	cancer	NOUN
ajst-17938	144	30	was	be	AUX
ajst-17938	144	31	discussed	discuss	VERB
ajst-17938	144	32	.	.	PUNCT
ajst-17938	145	1	by	by	ADP
ajst-17938	145	2	designing	design	VERB
ajst-17938	145	3	and	and	CCONJ
ajst-17938	145	4	synthesizing	synthesize	VERB
ajst-17938	145	5	a	a	DET
ajst-17938	145	6	series	series	NOUN
ajst-17938	145	7	of	of	ADP
ajst-17938	145	8	imides	imide	NOUN
ajst-17938	145	9	polyamine	polyamine	NOUN
ajst-17938	145	10	conjugates	conjugate	NOUN
ajst-17938	145	11	,	,	PUNCT
ajst-17938	145	12	we	we	PRON
ajst-17938	145	13	found	find	VERB
ajst-17938	145	14	that	that	SCONJ
ajst-17938	145	15	these	these	DET
ajst-17938	145	16	compounds	compound	NOUN
ajst-17938	145	17	can	can	AUX
ajst-17938	145	18	significantly	significantly	ADV
ajst-17938	145	19	reduce	reduce	VERB
ajst-17938	145	20	the	the	DET
ajst-17938	145	21	migration	migration	NOUN
ajst-17938	145	22	and	and	CCONJ
ajst-17938	145	23	invasion	invasion	NOUN
ajst-17938	145	24	ability	ability	NOUN
ajst-17938	145	25	of	of	ADP
ajst-17938	145	26	liver	liver	NOUN
ajst-17938	145	27	cancer	cancer	NOUN
ajst-17938	145	28	cells	cell	NOUN
ajst-17938	145	29	.	.	PUNCT
ajst-17938	146	1	further	further	PROPN
ajst-17938	146	2	mechanistic	mechanistic	ADJ
ajst-17938	146	3	studies	study	NOUN
ajst-17938	146	4	showed	show	VERB
ajst-17938	146	5	that	that	SCONJ
ajst-17938	146	6	these	these	DET
ajst-17938	146	7	compounds	compound	NOUN
ajst-17938	146	8	could	could	AUX
ajst-17938	146	9	inhibit	inhibit	VERB
ajst-17938	146	10	the	the	DET
ajst-17938	146	11	metastasis	metastasis	NOUN
ajst-17938	146	12	of	of	ADP
ajst-17938	146	13	liver	liver	NOUN
ajst-17938	146	14	cancer	cancer	NOUN
ajst-17938	146	15	cells	cell	NOUN
ajst-17938	146	16	by	by	ADP
ajst-17938	146	17	interfering	interfere	VERB
ajst-17938	146	18	with	with	ADP
ajst-17938	146	19	intracellular	intracellular	ADJ
ajst-17938	146	20	signaling	signal	VERB
ajst-17938	146	21	pathways	pathway	NOUN
ajst-17938	146	22	and	and	CCONJ
ajst-17938	146	23	affecting	affect	VERB
ajst-17938	146	24	cytoskeleton	cytoskeleton	NOUN
ajst-17938	146	25	reorganization	reorganization	NOUN
ajst-17938	146	26	.	.	PUNCT
ajst-17938	147	1	the	the	DET
ajst-17938	147	2	anti	anti	ADJ
ajst-17938	147	3	metastatic	metastatic	ADJ
ajst-17938	147	4	mechanisms	mechanism	NOUN
ajst-17938	147	5	of	of	ADP
ajst-17938	147	6	these	these	DET
ajst-17938	147	7	compounds	compound	NOUN
ajst-17938	147	8	include	include	VERB
ajst-17938	147	9	inducing	induce	VERB
ajst-17938	147	10	apoptosis	apoptosis	NOUN
ajst-17938	147	11	,	,	PUNCT
ajst-17938	147	12	inhibiting	inhibit	VERB
ajst-17938	147	13	proliferation	proliferation	NOUN
ajst-17938	147	14	,	,	PUNCT
ajst-17938	147	15	promoting	promote	VERB
ajst-17938	147	16	autophagy	autophagy	NOUN
ajst-17938	147	17	and	and	CCONJ
ajst-17938	147	18	cell	cell	NOUN
ajst-17938	147	19	cycle	cycle	NOUN
ajst-17938	147	20	arrest	arrest	NOUN
ajst-17938	147	21	of	of	ADP
ajst-17938	147	22	liver	liver	NOUN
ajst-17938	147	23	cancer	cancer	NOUN
ajst-17938	147	24	cells	cell	NOUN
ajst-17938	147	25	.	.	PUNCT
ajst-17938	148	1	these	these	DET
ajst-17938	148	2	mechanisms	mechanism	NOUN
ajst-17938	148	3	suggest	suggest	VERB
ajst-17938	148	4	that	that	SCONJ
ajst-17938	148	5	imides	imide	VERB
ajst-17938	148	6	polyamine	polyamine	NOUN
ajst-17938	148	7	conjugates	conjugate	NOUN
ajst-17938	148	8	have	have	VERB
ajst-17938	148	9	multifaceted	multifaceted	ADJ
ajst-17938	148	10	roles	role	NOUN
ajst-17938	148	11	in	in	ADP
ajst-17938	148	12	the	the	DET
ajst-17938	148	13	treatment	treatment	NOUN
ajst-17938	148	14	of	of	ADP
ajst-17938	148	15	liver	liver	NOUN
ajst-17938	148	16	cancer	cancer	NOUN
ajst-17938	148	17	.	.	PUNCT
ajst-17938	149	1	in	in	ADP
ajst-17938	149	2	animal	animal	NOUN
ajst-17938	149	3	models	model	NOUN
ajst-17938	149	4	,	,	PUNCT
ajst-17938	149	5	these	these	DET
ajst-17938	149	6	compounds	compound	NOUN
ajst-17938	149	7	can	can	AUX
ajst-17938	149	8	significantly	significantly	ADV
ajst-17938	149	9	reduce	reduce	VERB
ajst-17938	149	10	the	the	DET
ajst-17938	149	11	metastasis	metastasis	NOUN
ajst-17938	149	12	and	and	CCONJ
ajst-17938	149	13	recurrence	recurrence	NOUN
ajst-17938	149	14	of	of	ADP
ajst-17938	149	15	liver	liver	NOUN
ajst-17938	149	16	cancer	cancer	NOUN
ajst-17938	149	17	in	in	ADP
ajst-17938	149	18	mice	mouse	NOUN
ajst-17938	149	19	,	,	PUNCT
ajst-17938	149	20	and	and	CCONJ
ajst-17938	149	21	improve	improve	VERB
ajst-17938	149	22	the	the	DET
ajst-17938	149	23	survival	survival	NOUN
ajst-17938	149	24	rate	rate	NOUN
ajst-17938	149	25	of	of	ADP
ajst-17938	149	26	mice	mouse	NOUN
ajst-17938	149	27	.	.	PUNCT
ajst-17938	150	1	in	in	ADP
ajst-17938	150	2	addition	addition	NOUN
ajst-17938	150	3	,	,	PUNCT
ajst-17938	150	4	these	these	DET
ajst-17938	150	5	compounds	compound	NOUN
ajst-17938	150	6	can	can	AUX
ajst-17938	150	7	also	also	ADV
ajst-17938	150	8	improve	improve	VERB
ajst-17938	150	9	liver	liver	NOUN
ajst-17938	150	10	function	function	NOUN
ajst-17938	150	11	and	and	CCONJ
ajst-17938	150	12	reduce	reduce	VERB
ajst-17938	150	13	hepatic	hepatic	ADJ
ajst-17938	150	14	inflammatory	inflammatory	ADJ
ajst-17938	150	15	response	response	NOUN
ajst-17938	150	16	in	in	ADP
ajst-17938	150	17	mice	mice	NOUN
ajst-17938	150	18	with	with	ADP
ajst-17938	150	19	liver	liver	NOUN
ajst-17938	150	20	cancer	cancer	NOUN
ajst-17938	150	21	.	.	PUNCT
ajst-17938	151	1	however	however	ADV
ajst-17938	151	2	,	,	PUNCT
ajst-17938	151	3	although	although	SCONJ
ajst-17938	151	4	imides	imide	NOUN
ajst-17938	151	5	polyamine	polyamine	NOUN
ajst-17938	151	6	conjugates	conjugate	NOUN
ajst-17938	151	7	have	have	AUX
ajst-17938	151	8	shown	show	VERB
ajst-17938	151	9	good	good	ADJ
ajst-17938	151	10	application	application	NOUN
ajst-17938	151	11	prospects	prospect	NOUN
ajst-17938	151	12	in	in	ADP
ajst-17938	151	13	the	the	DET
ajst-17938	151	14	treatment	treatment	NOUN
ajst-17938	151	15	of	of	ADP
ajst-17938	151	16	liver	liver	NOUN
ajst-17938	151	17	cancer	cancer	NOUN
ajst-17938	151	18	,	,	PUNCT
ajst-17938	151	19	there	there	PRON
ajst-17938	151	20	are	be	VERB
ajst-17938	151	21	still	still	ADV
ajst-17938	151	22	some	some	DET
ajst-17938	151	23	problems	problem	NOUN
ajst-17938	151	24	that	that	PRON
ajst-17938	151	25	need	need	VERB
ajst-17938	151	26	to	to	PART
ajst-17938	151	27	be	be	AUX
ajst-17938	151	28	further	far	ADV
ajst-17938	151	29	studied	study	VERB
ajst-17938	151	30	and	and	CCONJ
ajst-17938	151	31	solved	solve	VERB
ajst-17938	151	32	.	.	PUNCT
ajst-17938	152	1	first	first	ADV
ajst-17938	152	2	,	,	PUNCT
ajst-17938	152	3	the	the	DET
ajst-17938	152	4	structure	structure	NOUN
ajst-17938	152	5	and	and	CCONJ
ajst-17938	152	6	activity	activity	NOUN
ajst-17938	152	7	of	of	ADP
ajst-17938	152	8	these	these	DET
ajst-17938	152	9	compounds	compound	NOUN
ajst-17938	152	10	need	need	VERB
ajst-17938	152	11	to	to	PART
ajst-17938	152	12	be	be	AUX
ajst-17938	152	13	further	far	ADV
ajst-17938	152	14	optimized	optimize	VERB
ajst-17938	152	15	to	to	PART
ajst-17938	152	16	improve	improve	VERB
ajst-17938	152	17	their	their	PRON
ajst-17938	152	18	anti	anti	ADJ
ajst-17938	152	19	metastatic	metastatic	ADJ
ajst-17938	152	20	effect	effect	NOUN
ajst-17938	152	21	and	and	CCONJ
ajst-17938	152	22	selectivity	selectivity	NOUN
ajst-17938	152	23	.	.	PUNCT
ajst-17938	153	1	second	second	ADJ
ajst-17938	153	2	,	,	PUNCT
ajst-17938	153	3	the	the	DET
ajst-17938	153	4	pharmacokinetics	pharmacokinetic	NOUN
ajst-17938	153	5	and	and	CCONJ
ajst-17938	153	6	toxicity	toxicity	NOUN
ajst-17938	153	7	of	of	ADP
ajst-17938	153	8	these	these	DET
ajst-17938	153	9	compounds	compound	NOUN
ajst-17938	153	10	need	need	VERB
ajst-17938	153	11	to	to	PART
ajst-17938	153	12	be	be	AUX
ajst-17938	153	13	further	far	ADV
ajst-17938	153	14	evaluated	evaluate	VERB
ajst-17938	153	15	to	to	PART
ajst-17938	153	16	ensure	ensure	VERB
ajst-17938	153	17	their	their	PRON
ajst-17938	153	18	safety	safety	NOUN
ajst-17938	153	19	and	and	CCONJ
ajst-17938	153	20	efficacy	efficacy	NOUN
ajst-17938	153	21	in	in	ADP
ajst-17938	153	22	clinical	clinical	ADJ
ajst-17938	153	23	applications	application	NOUN
ajst-17938	153	24	.	.	PUNCT
ajst-17938	154	1	in	in	ADP
ajst-17938	154	2	addition	addition	NOUN
ajst-17938	154	3	,	,	PUNCT
ajst-17938	154	4	the	the	DET
ajst-17938	154	5	mechanism	mechanism	NOUN
ajst-17938	154	6	of	of	ADP
ajst-17938	154	7	action	action	NOUN
ajst-17938	154	8	of	of	ADP
ajst-17938	154	9	these	these	DET
ajst-17938	154	10	compounds	compound	NOUN
ajst-17938	154	11	also	also	ADV
ajst-17938	154	12	needs	need	VERB
ajst-17938	154	13	further	far	ADV
ajst-17938	154	14	in	in	ADP
ajst-17938	154	15	-	-	PUNCT
ajst-17938	154	16	depth	depth	NOUN
ajst-17938	154	17	study	study	NOUN
ajst-17938	154	18	to	to	PART
ajst-17938	154	19	better	well	ADV
ajst-17938	154	20	understand	understand	VERB
ajst-17938	154	21	their	their	PRON
ajst-17938	154	22	role	role	NOUN
ajst-17938	154	23	in	in	ADP
ajst-17938	154	24	the	the	DET
ajst-17938	154	25	treatment	treatment	NOUN
ajst-17938	154	26	of	of	ADP
ajst-17938	154	27	liver	liver	NOUN
ajst-17938	154	28	cancer	cancer	NOUN
ajst-17938	154	29	.	.	PUNCT
ajst-17938	155	1	in	in	ADP
ajst-17938	155	2	the	the	DET
ajst-17938	155	3	future	future	NOUN
ajst-17938	155	4	,	,	PUNCT
ajst-17938	155	5	we	we	PRON
ajst-17938	155	6	will	will	AUX
ajst-17938	155	7	continue	continue	VERB
ajst-17938	155	8	to	to	PART
ajst-17938	155	9	optimize	optimize	VERB
ajst-17938	155	10	the	the	DET
ajst-17938	155	11	structure	structure	NOUN
ajst-17938	155	12	and	and	CCONJ
ajst-17938	155	13	activity	activity	NOUN
ajst-17938	155	14	of	of	ADP
ajst-17938	155	15	these	these	DET
ajst-17938	155	16	compounds	compound	NOUN
ajst-17938	155	17	and	and	CCONJ
ajst-17938	155	18	conduct	conduct	VERB
ajst-17938	155	19	clinical	clinical	ADJ
ajst-17938	155	20	trials	trial	NOUN
ajst-17938	155	21	to	to	PART
ajst-17938	155	22	verify	verify	VERB
ajst-17938	155	23	their	their	PRON
ajst-17938	155	24	efficacy	efficacy	NOUN
ajst-17938	155	25	and	and	CCONJ
ajst-17938	155	26	safety	safety	NOUN
ajst-17938	155	27	.	.	PUNCT
ajst-17938	156	1	in	in	ADP
ajst-17938	156	2	addition	addition	NOUN
ajst-17938	156	3	,	,	PUNCT
ajst-17938	156	4	we	we	PRON
ajst-17938	156	5	will	will	AUX
ajst-17938	156	6	further	far	ADV
ajst-17938	156	7	explore	explore	VERB
ajst-17938	156	8	the	the	DET
ajst-17938	156	9	mechanism	mechanism	NOUN
ajst-17938	156	10	of	of	ADP
ajst-17938	156	11	action	action	NOUN
ajst-17938	156	12	of	of	ADP
ajst-17938	156	13	these	these	DET
ajst-17938	156	14	compounds	compound	NOUN
ajst-17938	156	15	in	in	ADP
ajst-17938	156	16	order	order	NOUN
ajst-17938	156	17	to	to	PART
ajst-17938	156	18	provide	provide	VERB
ajst-17938	156	19	new	new	ADJ
ajst-17938	156	20	strategies	strategy	NOUN
ajst-17938	156	21	for	for	ADP
ajst-17938	156	22	the	the	DET
ajst-17938	156	23	prevention	prevention	NOUN
ajst-17938	156	24	and	and	CCONJ
ajst-17938	156	25	treatment	treatment	NOUN
ajst-17938	156	26	of	of	ADP
ajst-17938	156	27	liver	liver	NOUN
ajst-17938	156	28	cancer	cancer	NOUN
ajst-17938	156	29	.	.	PUNCT
ajst-17938	157	1	through	through	ADP
ajst-17938	157	2	these	these	DET
ajst-17938	157	3	studies	study	NOUN
ajst-17938	157	4	,	,	PUNCT
ajst-17938	157	5	we	we	PRON
ajst-17938	157	6	hope	hope	VERB
ajst-17938	157	7	to	to	PART
ajst-17938	157	8	provide	provide	VERB
ajst-17938	157	9	more	more	ADV
ajst-17938	157	10	effective	effective	ADJ
ajst-17938	157	11	treatment	treatment	NOUN
ajst-17938	157	12	for	for	ADP
ajst-17938	157	13	liver	liver	NOUN
ajst-17938	157	14	cancer	cancer	NOUN
ajst-17938	157	15	patients	patient	NOUN
ajst-17938	157	16	,	,	PUNCT
ajst-17938	157	17	improve	improve	VERB
ajst-17938	157	18	their	their	PRON
ajst-17938	157	19	survival	survival	NOUN
ajst-17938	157	20	rate	rate	NOUN
ajst-17938	157	21	and	and	CCONJ
ajst-17938	157	22	prognosis	prognosis	NOUN
ajst-17938	157	23	.	.	PUNCT
ajst-17938	158	1	in	in	ADP
ajst-17938	158	2	conclusion	conclusion	NOUN
ajst-17938	158	3	,	,	PUNCT
ajst-17938	158	4	the	the	DET
ajst-17938	158	5	imide	imide	ADJ
ajst-17938	158	6	polyamine	polyamine	NOUN
ajst-17938	158	7	conjugate	conjugate	NOUN
ajst-17938	158	8	developed	develop	VERB
ajst-17938	158	9	in	in	ADP
ajst-17938	158	10	this	this	DET
ajst-17938	158	11	study	study	NOUN
ajst-17938	158	12	has	have	VERB
ajst-17938	158	13	the	the	DET
ajst-17938	158	14	potential	potential	NOUN
ajst-17938	158	15	to	to	PART
ajst-17938	158	16	become	become	VERB
ajst-17938	158	17	a	a	DET
ajst-17938	158	18	new	new	ADJ
ajst-17938	158	19	anti	anti	ADJ
ajst-17938	158	20	metastatic	metastatic	ADJ
ajst-17938	158	21	drug	drug	NOUN
ajst-17938	158	22	for	for	ADP
ajst-17938	158	23	liver	liver	NOUN
ajst-17938	158	24	cancer	cancer	NOUN
ajst-17938	158	25	.	.	PUNCT
ajst-17938	159	1	however	however	ADV
ajst-17938	159	2	,	,	PUNCT
ajst-17938	159	3	further	further	ADJ
ajst-17938	159	4	research	research	NOUN
ajst-17938	159	5	and	and	CCONJ
ajst-17938	159	6	clinical	clinical	ADJ
ajst-17938	159	7	trials	trial	NOUN
ajst-17938	159	8	are	be	AUX
ajst-17938	159	9	still	still	ADV
ajst-17938	159	10	needed	need	VERB
ajst-17938	159	11	to	to	PART
ajst-17938	159	12	verify	verify	VERB
ajst-17938	159	13	its	its	PRON
ajst-17938	159	14	safety	safety	NOUN
ajst-17938	159	15	and	and	CCONJ
ajst-17938	159	16	efficacy	efficacy	NOUN
ajst-17938	159	17	in	in	ADP
ajst-17938	159	18	clinical	clinical	ADJ
ajst-17938	159	19	application	application	NOUN
ajst-17938	159	20	.	.	PUNCT
ajst-17938	160	1	through	through	ADP
ajst-17938	160	2	continuous	continuous	ADJ
ajst-17938	160	3	exploration	exploration	NOUN
ajst-17938	160	4	and	and	CCONJ
ajst-17938	160	5	research	research	NOUN
ajst-17938	160	6	,	,	PUNCT
ajst-17938	160	7	we	we	PRON
ajst-17938	160	8	are	be	AUX
ajst-17938	160	9	expected	expect	VERB
ajst-17938	160	10	to	to	PART
ajst-17938	160	11	provide	provide	VERB
ajst-17938	160	12	new	new	ADJ
ajst-17938	160	13	strategies	strategy	NOUN
ajst-17938	160	14	and	and	CCONJ
ajst-17938	160	15	methods	method	NOUN
ajst-17938	160	16	for	for	ADP
ajst-17938	160	17	the	the	DET
ajst-17938	160	18	prevention	prevention	NOUN
ajst-17938	160	19	and	and	CCONJ
ajst-17938	160	20	treatment	treatment	NOUN
ajst-17938	160	21	of	of	ADP
ajst-17938	160	22	liver	liver	NOUN
ajst-17938	160	23	cancer	cancer	NOUN
ajst-17938	160	24	,	,	PUNCT
ajst-17938	160	25	bring	bring	VERB
ajst-17938	160	26	more	more	ADV
ajst-17938	160	27	effective	effective	ADJ
ajst-17938	160	28	treatment	treatment	NOUN
ajst-17938	160	29	for	for	ADP
ajst-17938	160	30	patients	patient	NOUN
ajst-17938	160	31	,	,	PUNCT
ajst-17938	160	32	improve	improve	VERB
ajst-17938	160	33	their	their	PRON
ajst-17938	160	34	survival	survival	NOUN
ajst-17938	160	35	rate	rate	NOUN
ajst-17938	160	36	and	and	CCONJ
ajst-17938	160	37	prognosis[13]-[15	prognosis[13]-[15	PRON
ajst-17938	160	38	]	]	PUNCT
ajst-17938	160	39	.	.	PUNCT
ajst-17938	161	1	references	reference	NOUN
ajst-17938	161	2	[	[	X
ajst-17938	161	3	1	1	NUM
ajst-17938	161	4	]	]	PUNCT
ajst-17938	161	5	rangwala	rangwala	NOUN
ajst-17938	161	6	r	r	NOUN
ajst-17938	161	7	a	a	DET
ajst-17938	161	8	.anti	.anti	ADJ
ajst-17938	161	9	-	-	ADJ
ajst-17938	161	10	tissue	tissue	ADJ
ajst-17938	161	11	factor	factor	NOUN
ajst-17938	161	12	antibody	antibody	NOUN
ajst-17938	161	13	-	-	PUNCT
ajst-17938	161	14	drug	drug	NOUN
ajst-17938	161	15	conjugates	conjugate	NOUN
ajst-17938	161	16	and	and	CCONJ
ajst-17938	161	17	their	their	PRON
ajst-17938	161	18	use	use	NOUN
ajst-17938	161	19	in	in	ADP
ajst-17938	161	20	the	the	DET
ajst-17938	161	21	treatment	treatment	NOUN
ajst-17938	161	22	of	of	ADP
ajst-17938	161	23	cancer	cancer	NOUN
ajst-17938	161	24	:	:	PUNCT
ajst-17938	161	25	wo2021ep67855[p].wo2022002940a1[2024	wo2021ep67855[p].wo2022002940a1[2024	NOUN
ajst-17938	161	26	-	-	SYM
ajst-17938	161	27	0206	0206	NUM
ajst-17938	161	28	]	]	PUNCT
ajst-17938	161	29	.	.	PUNCT
ajst-17938	162	1	265	265	NUM
ajst-17938	163	1	[	[	X
ajst-17938	163	2	2	2	X
ajst-17938	163	3	]	]	PUNCT
ajst-17938	163	4	lim	lim	PROPN
ajst-17938	163	5	c	c	PROPN
ajst-17938	163	6	,	,	PUNCT
ajst-17938	163	7	turco	turco	PROPN
ajst-17938	163	8	c	c	PROPN
ajst-17938	163	9	,	,	PUNCT
ajst-17938	163	10	goumard	goumard	PROPN
ajst-17938	163	11	c	c	NOUN
ajst-17938	163	12	,	,	PUNCT
ajst-17938	163	13	et	et	NOUN
ajst-17938	163	14	al.perceptions	al.perception	NOUN
ajst-17938	163	15	of	of	ADP
ajst-17938	163	16	surgical	surgical	ADJ
ajst-17938	163	17	difficulty	difficulty	NOUN
ajst-17938	163	18	in	in	ADP
ajst-17938	163	19	liver	liver	NOUN
ajst-17938	163	20	transplantation	transplantation	NOUN
ajst-17938	163	21	:	:	PUNCT
ajst-17938	163	22	a	a	DET
ajst-17938	163	23	european	european	ADJ
ajst-17938	163	24	survey	survey	NOUN
ajst-17938	163	25	and	and	CCONJ
ajst-17938	163	26	development	development	NOUN
ajst-17938	163	27	of	of	ADP
ajst-17938	163	28	the	the	DET
ajst-17938	163	29	pitié	pitié	NOUN
ajst-17938	163	30	-	-	PUNCT
ajst-17938	163	31	salpêtrière	salpêtrière	NOUN
ajst-17938	163	32	classification[j].surgery	classification[j].surgery	PROPN
ajst-17938	163	33	,	,	PUNCT
ajst-17938	163	34	2023(4):174	2023(4):174	NUM
ajst-17938	163	35	.	.	PUNCT
ajst-17938	164	1	[	[	X
ajst-17938	164	2	3	3	X
ajst-17938	164	3	]	]	X
ajst-17938	164	4	wu	wu	PROPN
ajst-17938	164	5	d	d	PROPN
ajst-17938	164	6	,	,	PUNCT
ajst-17938	164	7	huang	huang	PROPN
ajst-17938	164	8	d	d	PROPN
ajst-17938	164	9	,	,	PUNCT
ajst-17938	164	10	yan	yan	PROPN
ajst-17938	165	1	w	w	PROPN
ajst-17938	165	2	,	,	PUNCT
ajst-17938	165	3	et	et	PROPN
ajst-17938	165	4	al.response	al.response	NOUN
ajst-17938	165	5	to	to	PART
ajst-17938	165	6	:	:	PUNCT
ajst-17938	165	7	comment	comment	VERB
ajst-17938	165	8	on	on	ADP
ajst-17938	165	9	'	'	PUNCT
ajst-17938	165	10	endof	endof	NOUN
ajst-17938	165	11	-	-	PUNCT
ajst-17938	165	12	treatment	treatment	NOUN
ajst-17938	165	13	hbcrag	hbcrag	NOUN
ajst-17938	165	14	and	and	CCONJ
ajst-17938	165	15	hbsab	hbsab	PROPN
ajst-17938	165	16	levels	level	NOUN
ajst-17938	165	17	identify	identify	VERB
ajst-17938	165	18	durable	durable	ADJ
ajst-17938	165	19	functional	functional	ADJ
ajst-17938	165	20	cure	cure	NOUN
ajst-17938	165	21	after	after	ADP
ajst-17938	165	22	peg	peg	NOUN
ajst-17938	165	23	-	-	PUNCT
ajst-17938	165	24	ifn	ifn	NOUN
ajst-17938	165	25	-	-	PUNCT
ajst-17938	165	26	based	base	VERB
ajst-17938	165	27	therapy	therapy	NOUN
ajst-17938	165	28	in	in	ADP
ajst-17938	165	29	patients	patient	NOUN
ajst-17938	165	30	with	with	ADP
ajst-17938	165	31	chb'[j].journal	chb'[j].journal	ADJ
ajst-17938	165	32	of	of	ADP
ajst-17938	165	33	hepatology	hepatology	NOUN
ajst-17938	165	34	:	:	PUNCT
ajst-17938	165	35	the	the	DET
ajst-17938	165	36	journal	journal	NOUN
ajst-17938	165	37	of	of	ADP
ajst-17938	165	38	the	the	DET
ajst-17938	165	39	european	european	PROPN
ajst-17938	165	40	association	association	PROPN
ajst-17938	165	41	for	for	ADP
ajst-17938	165	42	the	the	DET
ajst-17938	165	43	study	study	NOUN
ajst-17938	165	44	of	of	ADP
ajst-17938	165	45	the	the	DET
ajst-17938	165	46	liver	liver	NOUN
ajst-17938	165	47	,	,	PUNCT
ajst-17938	165	48	2023(5):79	2023(5):79	NUM
ajst-17938	165	49	.	.	PUNCT
ajst-17938	166	1	[	[	X
ajst-17938	166	2	4	4	NUM
ajst-17938	166	3	]	]	X
ajst-17938	166	4	zhang	zhang	PROPN
ajst-17938	166	5	ying	ying	PROPN
ajst-17938	166	6	-	-	PUNCT
ajst-17938	166	7	xuesun	xuesun	PROPN
ajst-17938	166	8	feng	feng	PROPN
ajst-17938	166	9	-	-	PUNCT
ajst-17938	166	10	xiali	xiali	PROPN
ajst-17938	166	11	xiao	xiao	PROPN
ajst-17938	166	12	-	-	PUNCT
ajst-17938	166	13	lingxu	lingxu	PROPN
ajst-17938	166	14	chunjunguo	chunjunguo	PROPN
ajst-17938	166	15	yu	yu	PROPN
ajst-17938	166	16	-	-	ADJ
ajst-17938	166	17	feichen	feichen	ADJ
ajst-17938	166	18	zi-meng.action	zi-meng.action	NOUN
ajst-17938	166	19	mechanism	mechanism	NOUN
ajst-17938	166	20	of	of	ADP
ajst-17938	166	21	yiqi	yiqi	NOUN
ajst-17938	166	22	hexue	hexue	NOUN
ajst-17938	166	23	formula	formula	NOUN
ajst-17938	166	24	in	in	ADP
ajst-17938	166	25	the	the	DET
ajst-17938	166	26	treatment	treatment	NOUN
ajst-17938	166	27	of	of	ADP
ajst-17938	166	28	liver	liver	NOUN
ajst-17938	166	29	cirrhosis	cirrhosis	NOUN
ajst-17938	166	30	based	base	VERB
ajst-17938	166	31	on	on	ADP
ajst-17938	166	32	network	network	NOUN
ajst-17938	166	33	pharmacology	pharmacology	NOUN
ajst-17938	166	34	and	and	CCONJ
ajst-17938	166	35	experimental	experimental	ADJ
ajst-17938	166	36	verification[j	verification[j	NOUN
ajst-17938	166	37	]	]	X
ajst-17938	166	38	.	.	PUNCT
ajst-17938	166	39	2022	2022	NUM
ajst-17938	166	40	,	,	PUNCT
ajst-17938	166	41	28(18):62	28(18):62	NUM
ajst-17938	166	42	-	-	SYM
ajst-17938	166	43	69	69	NUM
ajst-17938	166	44	.	.	PUNCT
ajst-17938	167	1	[	[	X
ajst-17938	167	2	5	5	X
ajst-17938	167	3	]	]	PUNCT
ajst-17938	167	4	kim	kim	PROPN
ajst-17938	167	5	j	j	PROPN
ajst-17938	167	6	,	,	PUNCT
ajst-17938	167	7	yun	yun	PROPN
ajst-17938	167	8	y	y	PROPN
ajst-17938	167	9	h	h	PROPN
ajst-17938	167	10	,	,	PUNCT
ajst-17938	167	11	jung	jung	PROPN
ajst-17938	167	12	y	y	PROPN
ajst-17938	167	13	.therapeutic	.therapeutic	PROPN
ajst-17938	167	14	potential	potential	NOUN
ajst-17938	167	15	of	of	ADP
ajst-17938	167	16	micrornas	microrna	NOUN
ajst-17938	167	17	and	and	CCONJ
ajst-17938	167	18	their	their	PRON
ajst-17938	167	19	nanoparticle	nanoparticle	NOUN
ajst-17938	167	20	-	-	PUNCT
ajst-17938	167	21	based	base	VERB
ajst-17938	167	22	delivery	delivery	NOUN
ajst-17938	167	23	in	in	ADP
ajst-17938	167	24	the	the	DET
ajst-17938	167	25	treatment	treatment	NOUN
ajst-17938	167	26	of	of	ADP
ajst-17938	167	27	liver	liver	NOUN
ajst-17938	167	28	fibrosis[j	fibrosis[j	PROPN
ajst-17938	167	29	]	]	PUNCT
ajst-17938	167	30	.	.	PUNCT
ajst-17938	168	1	2022.doi:10.1007/978	2022.doi:10.1007/978	NUM
ajst-17938	168	2	-	-	PUNCT
ajst-17938	168	3	3030	3030	NUM
ajst-17938	168	4	-	-	PUNCT
ajst-17938	168	5	93333	93333	NUM
ajst-17938	168	6	-	-	PUNCT
ajst-17938	168	7	3_1	3_1	NUM
ajst-17938	168	8	.	.	PUNCT
ajst-17938	169	1	[	[	X
ajst-17938	169	2	6	6	NUM
ajst-17938	169	3	]	]	PUNCT
ajst-17938	169	4	gough	gough	PROPN
ajst-17938	169	5	m	m	PROPN
ajst-17938	169	6	,	,	PUNCT
ajst-17938	169	7	kwah	kwah	PROPN
ajst-17938	169	8	k	k	PROPN
ajst-17938	169	9	,	,	PUNCT
ajst-17938	169	10	khan	khan	PROPN
ajst-17938	169	11	t	t	PROPN
ajst-17938	169	12	,	,	PUNCT
ajst-17938	169	13	et	et	PROPN
ajst-17938	169	14	al.development	al.development	ADP
ajst-17938	169	15	of	of	ADP
ajst-17938	169	16	antibodydrug	antibodydrug	NOUN
ajst-17938	169	17	conjugates	conjugate	NOUN
ajst-17938	169	18	targeting	target	VERB
ajst-17938	169	19	the	the	DET
ajst-17938	169	20	cdcp1	cdcp1	NOUN
ajst-17938	169	21	receptor	receptor	NOUN
ajst-17938	169	22	for	for	ADP
ajst-17938	169	23	the	the	DET
ajst-17938	169	24	treatment	treatment	NOUN
ajst-17938	169	25	of	of	ADP
ajst-17938	169	26	triple	triple	ADJ
ajst-17938	169	27	negative	negative	ADJ
ajst-17938	169	28	and	and	CCONJ
ajst-17938	169	29	metastatic	metastatic	ADJ
ajst-17938	169	30	breast	breast	NOUN
ajst-17938	169	31	cancer[j].european	cancer[j].european	PROPN
ajst-17938	169	32	journal	journal	PROPN
ajst-17938	169	33	of	of	ADP
ajst-17938	169	34	cancer	cancer	NOUN
ajst-17938	169	35	,	,	PUNCT
ajst-17938	169	36	2022	2022	NUM
ajst-17938	169	37	.	.	PUNCT
ajst-17938	170	1	[	[	X
ajst-17938	170	2	7	7	NUM
ajst-17938	170	3	]	]	X
ajst-17938	170	4	begum	begum	X
ajst-17938	170	5	s	s	PROPN
ajst-17938	170	6	a	a	DET
ajst-17938	170	7	,	,	PUNCT
ajst-17938	170	8	kamal	kamal	PROPN
ajst-17938	171	1	a	a	DET
ajst-17938	171	2	.what	.what	PRON
ajst-17938	171	3	are	be	AUX
ajst-17938	171	4	the	the	DET
ajst-17938	171	5	challenges	challenge	NOUN
ajst-17938	171	6	involved	involve	VERB
ajst-17938	171	7	in	in	ADP
ajst-17938	171	8	the	the	DET
ajst-17938	171	9	strategies	strategy	NOUN
ajst-17938	171	10	for	for	ADP
ajst-17938	171	11	future	future	ADJ
ajst-17938	171	12	antibody	antibody	NOUN
ajst-17938	171	13	-	-	PUNCT
ajst-17938	171	14	drug	drug	NOUN
ajst-17938	171	15	conjugate	conjugate	ADJ
ajst-17938	171	16	discovery	discovery	NOUN
ajst-17938	171	17	and	and	CCONJ
ajst-17938	171	18	development	development	NOUN
ajst-17938	171	19	for	for	ADP
ajst-17938	171	20	oncology?[j].expert	oncology?[j].expert	NOUN
ajst-17938	171	21	opinion	opinion	NOUN
ajst-17938	171	22	on	on	ADP
ajst-17938	171	23	drug	drug	NOUN
ajst-17938	171	24	discovery	discovery	NOUN
ajst-17938	171	25	,	,	PUNCT
ajst-17938	171	26	2023(1/6):18	2023(1/6):18	NUM
ajst-17938	171	27	.	.	PUNCT
ajst-17938	172	1	[	[	X
ajst-17938	172	2	8	8	NUM
ajst-17938	172	3	]	]	X
ajst-17938	172	4	chiang	chiang	PROPN
ajst-17938	172	5	,	,	PUNCT
ajst-17938	172	6	tsaiyu	tsaiyu	NOUN
ajst-17938	172	7	,	,	PUNCT
ajst-17938	172	8	sung	sung	PROPN
ajst-17938	172	9	,	,	PUNCT
ajst-17938	172	10	et	et	NOUN
ajst-17938	172	11	al.development	al.development	NOUN
ajst-17938	172	12	and	and	CCONJ
ajst-17938	172	13	characterization	characterization	NOUN
ajst-17938	172	14	of	of	ADP
ajst-17938	172	15	sorafenib	sorafenib	NOUN
ajst-17938	172	16	-	-	PUNCT
ajst-17938	172	17	loaded	load	VERB
ajst-17938	172	18	plga	plga	NOUN
ajst-17938	172	19	nanoparticles	nanoparticle	NOUN
ajst-17938	172	20	for	for	ADP
ajst-17938	172	21	the	the	DET
ajst-17938	172	22	systemic	systemic	ADJ
ajst-17938	172	23	treatment	treatment	NOUN
ajst-17938	172	24	of	of	ADP
ajst-17938	172	25	liver	liver	NOUN
ajst-17938	172	26	fibrosis	fibrosis	NOUN
ajst-17938	172	27	:	:	PUNCT
ajst-17938	172	28	wo2021cn140727[p].wo2022135503a1[2024	wo2021cn140727[p].wo2022135503a1[2024	NOUN
ajst-17938	172	29	-	-	NOUN
ajst-17938	172	30	0206	0206	NUM
ajst-17938	172	31	]	]	PUNCT
ajst-17938	172	32	.	.	PUNCT
ajst-17938	173	1	[	[	X
ajst-17938	173	2	9	9	NUM
ajst-17938	173	3	]	]	PUNCT
ajst-17938	173	4	mamdooh	mamdooh	VERB
ajst-17938	173	5	g	g	PROPN
ajst-17938	173	6	,	,	PUNCT
ajst-17938	173	7	badr	badr	PROPN
ajst-17938	173	8	e	e	PROPN
ajst-17938	173	9	n	n	PROPN
ajst-17938	173	10	k	k	PROPN
ajst-17938	173	11	,	,	PUNCT
ajst-17938	173	12	mai	mai	PROPN
ajst-17938	173	13	e	e	PROPN
ajst-17938	173	14	d	d	PROPN
ajst-17938	173	15	.anti	.anti	ADJ
ajst-17938	173	16	-	-	ADJ
ajst-17938	173	17	radiation	radiation	ADJ
ajst-17938	173	18	effect	effect	NOUN
ajst-17938	173	19	of	of	ADP
ajst-17938	173	20	mrn-100	mrn-100	NOUN
ajst-17938	173	21	:	:	PUNCT
ajst-17938	173	22	a	a	DET
ajst-17938	173	23	hydro	hydro	NOUN
ajst-17938	173	24	-	-	PUNCT
ajst-17938	173	25	ferrate	ferrate	NOUN
ajst-17938	173	26	fluid	fluid	NOUN
ajst-17938	173	27	,	,	PUNCT
ajst-17938	173	28	in	in	ADP
ajst-17938	173	29	vivo[j].journal	vivo[j].journal	NOUN
ajst-17938	173	30	of	of	ADP
ajst-17938	173	31	radiation	radiation	NOUN
ajst-17938	173	32	research	research	NOUN
ajst-17938	173	33	,	,	PUNCT
ajst-17938	173	34	2024	2024	NUM
ajst-17938	173	35	.	.	PUNCT
ajst-17938	174	1	[	[	X
ajst-17938	174	2	10	10	NUM
ajst-17938	174	3	]	]	PUNCT
ajst-17938	174	4	banzato	banzato	NOUN
ajst-17938	174	5	a	a	DET
ajst-17938	174	6	,	,	PUNCT
ajst-17938	174	7	bello	bello	PROPN
ajst-17938	174	8	m	m	PROPN
ajst-17938	174	9	,	,	PUNCT
ajst-17938	174	10	daniele_bernardini	daniele_bernardini	PROPN
ajst-17938	174	11	,	,	PUNCT
ajst-17938	174	12	et	et	NOUN
ajst-17938	174	13	al.a	al.a	ADJ
ajst-17938	174	14	novel	novel	NOUN
ajst-17938	174	15	radiotherapy	radiotherapy	NOUN
ajst-17938	174	16	approach	approach	NOUN
ajst-17938	174	17	based	base	VERB
ajst-17938	174	18	on	on	ADP
ajst-17938	174	19	188re	188re	NOUN
ajst-17938	174	20	-	-	PUNCT
ajst-17938	174	21	hyaluronic	hyaluronic	NOUN
ajst-17938	174	22	acid	acid	NOUN
ajst-17938	174	23	for	for	ADP
ajst-17938	174	24	the	the	DET
ajst-17938	174	25	liver	liver	NOUN
ajst-17938	174	26	-	-	PUNCT
ajst-17938	174	27	focused	focus	VERB
ajst-17938	174	28	treatment	treatment	NOUN
ajst-17938	174	29	of	of	ADP
ajst-17938	174	30	primary	primary	ADJ
ajst-17938	174	31	and	and	CCONJ
ajst-17938	174	32	metastatic	metastatic	ADJ
ajst-17938	174	33	tumors[j	tumors[j	NOUN
ajst-17938	174	34	]	]	PUNCT
ajst-17938	174	35	.	.	PUNCT
ajst-17938	175	1	2022	2022	NUM
ajst-17938	175	2	.	.	PUNCT
ajst-17938	176	1	[	[	X
ajst-17938	176	2	11	11	NUM
ajst-17938	176	3	]	]	PUNCT
ajst-17938	176	4	wang	wang	PROPN
ajst-17938	176	5	j	j	PROPN
ajst-17938	176	6	,	,	PUNCT
ajst-17938	176	7	wan	wan	PROPN
ajst-17938	176	8	l	l	PROPN
ajst-17938	176	9	,	,	PUNCT
ajst-17938	176	10	huang	huang	PROPN
ajst-17938	176	11	g	g	PROPN
ajst-17938	176	12	,	,	PUNCT
ajst-17938	176	13	et	et	NOUN
ajst-17938	176	14	al.comparison	al.comparison	NOUN
ajst-17938	176	15	of	of	ADP
ajst-17938	176	16	high	high	ADJ
ajst-17938	176	17	-	-	PUNCT
ajst-17938	176	18	intensity	intensity	NOUN
ajst-17938	176	19	focused	focus	VERB
ajst-17938	176	20	ultrasound	ultrasound	NOUN
ajst-17938	176	21	and	and	CCONJ
ajst-17938	176	22	microwave	microwave	NOUN
ajst-17938	176	23	ablation	ablation	NOUN
ajst-17938	176	24	for	for	ADP
ajst-17938	176	25	the	the	DET
ajst-17938	176	26	treatment	treatment	NOUN
ajst-17938	176	27	of	of	ADP
ajst-17938	176	28	small	small	ADJ
ajst-17938	176	29	liver	liver	NOUN
ajst-17938	176	30	metastatic	metastatic	ADJ
ajst-17938	176	31	tumors[j].journal	tumors[j].journal	NOUN
ajst-17938	176	32	of	of	ADP
ajst-17938	176	33	international	international	ADJ
ajst-17938	176	34	medical	medical	ADJ
ajst-17938	176	35	research	research	NOUN
ajst-17938	176	36	,	,	PUNCT
ajst-17938	176	37	2023(4).doi:10.1177/03000605231165551	2023(4).doi:10.1177/03000605231165551	NUM
ajst-17938	176	38	.	.	PUNCT
ajst-17938	177	1	[	[	X
ajst-17938	177	2	12	12	NUM
ajst-17938	177	3	]	]	PUNCT
ajst-17938	177	4	fernandes	fernande	NOUN
ajst-17938	177	5	e	e	PROPN
ajst-17938	178	1	d	d	X
ajst-17938	178	2	s	s	PROPN
ajst-17938	178	3	m	m	PROPN
ajst-17938	178	4	,	,	PUNCT
ajst-17938	178	5	souza	souza	PROPN
ajst-17938	178	6	g	g	PROPN
ajst-17938	178	7	o	o	PROPN
ajst-17938	178	8	d	d	PROPN
ajst-17938	178	9	,	,	PUNCT
ajst-17938	178	10	braga	braga	NOUN
ajst-17938	178	11	e	e	PROPN
ajst-17938	178	12	p	p	PROPN
ajst-17938	178	13	,	,	PUNCT
ajst-17938	178	14	et	et	PROPN
ajst-17938	178	15	al.an	al.an	PROPN
ajst-17938	178	16	experience	experience	NOUN
ajst-17938	178	17	on	on	ADP
ajst-17938	178	18	living	live	VERB
ajst-17938	178	19	donor	donor	NOUN
ajst-17938	178	20	liver	liver	NOUN
ajst-17938	178	21	transplantation	transplantation	NOUN
ajst-17938	178	22	for	for	ADP
ajst-17938	178	23	colorectal	colorectal	ADJ
ajst-17938	178	24	liver	liver	NOUN
ajst-17938	178	25	metastasis	metastasis	NOUN
ajst-17938	178	26	in	in	ADP
ajst-17938	178	27	south	south	PROPN
ajst-17938	178	28	america	america	PROPN
ajst-17938	178	29	:	:	PUNCT
ajst-17938	178	30	a	a	DET
ajst-17938	178	31	new	new	ADJ
ajst-17938	178	32	era	era	NOUN
ajst-17938	178	33	in	in	ADP
ajst-17938	178	34	transplant	transplant	NOUN
ajst-17938	178	35	oncology[j	oncology[j	NOUN
ajst-17938	178	36	]	]	PUNCT
ajst-17938	178	37	.	.	PUNCT
ajst-17938	179	1	2023	2023	NUM
ajst-17938	179	2	.	.	PUNCT
ajst-17938	180	1	[	[	X
ajst-17938	180	2	13	13	NUM
ajst-17938	180	3	]	]	PUNCT
ajst-17938	180	4	xu	xu	PROPN
ajst-17938	181	1	h	h	PROPN
ajst-17938	181	2	,	,	PUNCT
ajst-17938	181	3	dong	dong	PROPN
ajst-17938	181	4	z	z	PROPN
ajst-17938	181	5	.research	.research	NOUN
ajst-17938	181	6	progress	progress	NOUN
ajst-17938	181	7	on	on	ADP
ajst-17938	181	8	brownadipose	brownadipose	NOUN
ajst-17938	181	9	tissue	tissue	NOUN
ajst-17938	181	10	in	in	ADP
ajst-17938	181	11	treatment	treatment	NOUN
ajst-17938	181	12	of	of	ADP
ajst-17938	181	13	metabolic	metabolic	NOUN
ajst-17938	181	14	-	-	PUNCT
ajst-17938	181	15	associated	associate	VERB
ajst-17938	181	16	fatty	fatty	NOUN
ajst-17938	181	17	liver	liver	NOUN
ajst-17938	181	18	disease	disease	NOUN
ajst-17938	181	19	and	and	CCONJ
ajst-17938	181	20	imaging	imaging	NOUN
ajst-17938	181	21	evaluation[j].journal	evaluation[j].journal	ADJ
ajst-17938	181	22	of	of	ADP
ajst-17938	181	23	new	new	ADJ
ajst-17938	181	24	medicine	medicine	NOUN
ajst-17938	181	25	,	,	PUNCT
ajst-17938	181	26	2022	2022	NUM
ajst-17938	181	27	,	,	PUNCT
ajst-17938	181	28	53(10):723	53(10):723	PROPN
ajst-17938	181	29	-	-	SYM
ajst-17938	181	30	726.doi:10.3969	726.doi:10.3969	NUM
ajst-17938	181	31	/	/	PUNCT
ajst-17938	181	32	j.issn.0253	j.issn.0253	NOUN
ajst-17938	181	33	-	-	PUNCT
ajst-17938	181	34	9802.2022.10.004	9802.2022.10.004	PROPN
ajst-17938	181	35	.	.	PUNCT
ajst-17938	182	1	[	[	X
ajst-17938	182	2	14	14	NUM
ajst-17938	182	3	]	]	X
ajst-17938	182	4	lin	lin	PROPN
ajst-17938	182	5	g	g	PROPN
ajst-17938	182	6	,	,	PUNCT
ajst-17938	182	7	zhan	zhan	PROPN
ajst-17938	182	8	w	w	PROPN
ajst-17938	182	9	,	,	PUNCT
ajst-17938	182	10	zhang	zhang	PROPN
ajst-17938	182	11	h	h	PROPN
ajst-17938	182	12	,	,	PUNCT
ajst-17938	182	13	et	et	NOUN
ajst-17938	182	14	al.artemisininproteasome	al.artemisininproteasome	VERB
ajst-17938	182	15	inhibitor	inhibitor	NOUN
ajst-17938	182	16	conjugates	conjugate	NOUN
ajst-17938	182	17	and	and	CCONJ
ajst-17938	182	18	their	their	PRON
ajst-17938	182	19	use	use	NOUN
ajst-17938	182	20	in	in	ADP
ajst-17938	182	21	the	the	DET
ajst-17938	182	22	treatment	treatment	NOUN
ajst-17938	182	23	of	of	ADP
ajst-17938	182	24	disease	disease	NOUN
ajst-17938	182	25	:	:	PUNCT
ajst-17938	182	26	wo2022us13129[p].wo2022159581a2[202402	wo2022us13129[p].wo2022159581a2[202402	X
ajst-17938	182	27	-	-	SYM
ajst-17938	182	28	06	06	NUM
ajst-17938	182	29	]	]	PUNCT
ajst-17938	182	30	.	.	PUNCT
ajst-17938	183	1	[	[	X
ajst-17938	183	2	15	15	NUM
ajst-17938	183	3	]	]	X
ajst-17938	183	4	anne	anne	PROPN
ajst-17938	183	5	a.	a.	PROPN
ajst-17938	183	6	a	a	PROPN
ajst-17938	183	7	,	,	PUNCT
ajst-17938	183	8	babatunde	babatunde	PROPN
ajst-17938	183	9	j.	j.	PROPN
ajst-17938	183	10	o	o	PROPN
ajst-17938	183	11	,	,	PUNCT
ajst-17938	183	12	olorunfemi	olorunfemi	PROPN
ajst-17938	183	13	r.	r.	PROPN
ajst-17938	183	14	m	m	PROPN
ajst-17938	183	15	,	,	PUNCT
ajst-17938	183	16	et	et	NOUN
ajst-17938	183	17	al.treatment	al.treatment	NOUN
ajst-17938	183	18	with	with	ADP
ajst-17938	183	19	protocatechuic	protocatechuic	PROPN
ajst-17938	183	20	acid	acid	PROPN
ajst-17938	183	21	attenuates	attenuate	VERB
ajst-17938	183	22	cisplatin	cisplatin	NOUN
ajst-17938	183	23	-	-	PUNCT
ajst-17938	183	24	induced	induce	VERB
ajst-17938	183	25	toxicity	toxicity	NOUN
ajst-17938	183	26	in	in	ADP
ajst-17938	183	27	the	the	DET
ajst-17938	183	28	brain	brain	NOUN
ajst-17938	183	29	and	and	CCONJ
ajst-17938	183	30	liver	liver	NOUN
ajst-17938	183	31	of	of	ADP
ajst-17938	183	32	male	male	ADJ
ajst-17938	183	33	wistar	wistar	PROPN
ajst-17938	183	34	rats[j].advances	rats[j].advance	NOUN
ajst-17938	183	35	in	in	ADP
ajst-17938	183	36	traditional	traditional	ADJ
ajst-17938	183	37	medicine	medicine	NOUN
ajst-17938	183	38	.	.	PUNCT
ajst-17938	184	1	2023(1):23	2023(1):23	NUM
ajst-17938	184	2	.	.	PUNCT
ajst-17938	185	1	[	[	X
ajst-17938	185	2	16	16	NUM
ajst-17938	185	3	]	]	SYM
ajst-17938	185	4	d'hooge	d'hooge	PROPN
ajst-17938	185	5	f	f	PROPN
ajst-17938	185	6	,	,	PUNCT
ajst-17938	185	7	barret	barret	VERB
ajst-17938	185	8	j	j	PROPN
ajst-17938	185	9	m	m	PROPN
ajst-17938	185	10	,	,	PUNCT
ajst-17938	185	11	prost	prost	PROPN
ajst-17938	185	12	j	j	PROPN
ajst-17938	186	1	f	f	PROPN
ajst-17938	186	2	,	,	PUNCT
ajst-17938	186	3	et	et	NOUN
ajst-17938	186	4	al.amhrii	al.amhrii	ADJ
ajst-17938	186	5	-	-	ADJ
ajst-17938	186	6	binding	bind	VERB
ajst-17938	186	7	antibody	antibody	NOUN
ajst-17938	186	8	drug	drug	NOUN
ajst-17938	186	9	conjugates	conjugate	NOUN
ajst-17938	186	10	and	and	CCONJ
ajst-17938	186	11	their	their	PRON
ajst-17938	186	12	use	use	NOUN
ajst-17938	186	13	thereof	thereof	ADV
ajst-17938	186	14	in	in	ADP
ajst-17938	186	15	the	the	DET
ajst-17938	186	16	treatment	treatment	NOUN
ajst-17938	186	17	of	of	ADP
ajst-17938	186	18	cancers	cancer	NOUN
ajst-17938	186	19	:	:	PUNCT
ajst-17938	186	20	ep20200764106[p].ep4025603a1[2024	ep20200764106[p].ep4025603a1[2024	VERB
ajst-17938	186	21	-	-	PUNCT
ajst-17938	186	22	02	02	NUM
ajst-17938	186	23	-	-	PUNCT
ajst-17938	186	24	06	06	NUM
ajst-17938	186	25	]	]	PUNCT
ajst-17938	186	26	.	.	PUNCT
ajst-17938	187	1	[	[	X
ajst-17938	187	2	17	17	NUM
ajst-17938	187	3	]	]	X
ajst-17938	187	4	li	li	PROPN
ajst-17938	187	5	xiaoliu	xiaoliu	PROPN
ajst-17938	187	6	,	,	PUNCT
ajst-17938	187	7	ma	ma	PROPN
ajst-17938	187	8	donglai	donglai	PROPN
ajst-17938	187	9	,	,	PUNCT
ajst-17938	187	10	yang	yang	PROPN
ajst-17938	187	11	hailong	hailong	PROPN
ajst-17938	187	12	,	,	PUNCT
ajst-17938	187	13	et	et	PROPN
ajst-17938	187	14	al	al	PROPN
ajst-17938	187	15	.	.	PUNCT
ajst-17938	187	16	synthesis	synthesis	PROPN
ajst-17938	187	17	,	,	PUNCT
ajst-17938	187	18	antitumor	antitumor	NOUN
ajst-17938	187	19	activity	activity	NOUN
ajst-17938	187	20	,	,	PUNCT
ajst-17938	187	21	and	and	CCONJ
ajst-17938	187	22	dna	dna	PROPN
ajst-17938	187	23	binding	binding	NOUN
ajst-17938	187	24	of	of	ADP
ajst-17938	187	25	acridine	acridine	ADJ
ajst-17938	187	26	polyamine	polyamine	NOUN
ajst-17938	187	27	conjugates	conjugate	NOUN
ajst-17938	187	28	[	[	X
ajst-17938	187	29	j	j	X
ajst-17938	187	30	]	]	X
ajst-17938	187	31	.	.	PUNCT
ajst-17938	188	1	journal	journal	PROPN
ajst-17938	188	2	of	of	ADP
ajst-17938	188	3	chemistry	chemistry	NOUN
ajst-17938	188	4	of	of	ADP
ajst-17938	188	5	higher	high	ADJ
ajst-17938	188	6	education	education	NOUN
ajst-17938	188	7	,	,	PUNCT
ajst-17938	188	8	2020	2020	NUM
ajst-17938	188	9	,	,	PUNCT
ajst-17938	188	10	35	35	NUM
ajst-17938	188	11	(	(	PUNCT
ajst-17938	188	12	6	6	NUM
ajst-17938	188	13	)	)	PUNCT
ajst-17938	189	1	[	[	X
ajst-17938	189	2	18	18	NUM
ajst-17938	189	3	]	]	X
ajst-17938	189	4	li	li	PROPN
ajst-17938	189	5	xiaoliu	xiaoliu	PROPN
ajst-17938	189	6	,	,	PUNCT
ajst-17938	189	7	ma	ma	PROPN
ajst-17938	189	8	donglai	donglai	PROPN
ajst-17938	189	9	,	,	PUNCT
ajst-17938	189	10	yang	yang	PROPN
ajst-17938	189	11	hailong	hailong	PROPN
ajst-17938	189	12	,	,	PUNCT
ajst-17938	189	13	et	et	PROPN
ajst-17938	189	14	al	al	PROPN
ajst-17938	189	15	.	.	PUNCT
ajst-17938	189	16	synthesis	synthesis	PROPN
ajst-17938	189	17	,	,	PUNCT
ajst-17938	189	18	antitumor	antitumor	NOUN
ajst-17938	189	19	activity	activity	NOUN
ajst-17938	189	20	,	,	PUNCT
ajst-17938	189	21	and	and	CCONJ
ajst-17938	189	22	dna	dna	PROPN
ajst-17938	189	23	binding	binding	NOUN
ajst-17938	189	24	of	of	ADP
ajst-17938	189	25	acridine	acridine	ADJ
ajst-17938	189	26	polyamine	polyamine	NOUN
ajst-17938	189	27	conjugates	conjugate	NOUN
ajst-17938	189	28	[	[	X
ajst-17938	189	29	j	j	X
ajst-17938	189	30	]	]	X
ajst-17938	189	31	.	.	PUNCT
ajst-17938	190	1	journal	journal	PROPN
ajst-17938	190	2	of	of	ADP
ajst-17938	190	3	chemistry	chemistry	NOUN
ajst-17938	190	4	,	,	PUNCT
ajst-17938	190	5	higher	high	ADJ
ajst-17938	190	6	education	education	NOUN
ajst-17938	190	7	,	,	PUNCT
ajst-17938	190	8	2024	2024	NUM
ajst-17938	190	9	.	.	PUNCT
ajst-17938	191	1	[	[	X
ajst-17938	191	2	19	19	NUM
ajst-17938	191	3	]	]	X
ajst-17938	191	4	luo	luo	PROPN
ajst-17938	191	5	wen	wen	PROPN
ajst-17938	191	6	,	,	PUNCT
ajst-17938	191	7	huang	huang	PROPN
ajst-17938	191	8	kai	kai	PROPN
ajst-17938	191	9	,	,	PUNCT
ajst-17938	191	10	zhang	zhang	PROPN
ajst-17938	191	11	zhen	zhen	PROPN
ajst-17938	191	12	,	,	PUNCT
ajst-17938	191	13	et	et	PROPN
ajst-17938	191	14	al	al	PROPN
ajst-17938	191	15	.	.	PROPN
ajst-17938	191	16	design	design	NOUN
ajst-17938	191	17	,	,	PUNCT
ajst-17938	191	18	synthesis	synthesis	NOUN
ajst-17938	191	19	,	,	PUNCT
ajst-17938	191	20	and	and	CCONJ
ajst-17938	191	21	cholinesterase	cholinesterase	VERB
ajst-17938	191	22	inhibitory	inhibitory	ADJ
ajst-17938	191	23	activity	activity	NOUN
ajst-17938	191	24	of	of	ADP
ajst-17938	191	25	quinoline	quinoline	ADJ
ajst-17938	191	26	polyamine	polyamine	NOUN
ajst-17938	191	27	conjugates	conjugate	NOUN
ajst-17938	192	1	[	[	X
ajst-17938	192	2	j	j	X
ajst-17938	192	3	]	]	X
ajst-17938	192	4	.	.	PUNCT
ajst-17938	193	1	journal	journal	PROPN
ajst-17938	193	2	of	of	ADP
ajst-17938	193	3	pharmacy	pharmacy	NOUN
ajst-17938	193	4	,	,	PUNCT
ajst-17938	193	5	2023	2023	NUM
ajst-17938	193	6	,	,	PUNCT
ajst-17938	193	7	48	48	NUM
ajst-17938	193	8	(	(	PUNCT
ajst-17938	193	9	2	2	NUM
ajst-17938	193	10	):	):	PUNCT
ajst-17938	193	11	7	7	NUM
ajst-17938	193	12	.	.	PUNCT
ajst-17938	194	1	[	[	X
ajst-17938	194	2	20	20	NUM
ajst-17938	194	3	]	]	X
ajst-17938	194	4	tian	tian	PROPN
ajst-17938	194	5	zhiyong	zhiyong	PROPN
ajst-17938	194	6	,	,	PUNCT
ajst-17938	194	7	su	su	PROPN
ajst-17938	194	8	leipeng	leipeng	PROPN
ajst-17938	194	9	,	,	PUNCT
ajst-17938	194	10	wang	wang	PROPN
ajst-17938	194	11	dan	dan	PROPN
ajst-17938	194	12	,	,	PUNCT
ajst-17938	194	13	et	et	PROPN
ajst-17938	194	14	al	al	PROPN
ajst-17938	194	15	.	.	PUNCT
ajst-17938	194	16	spectroscopic	spectroscopic	ADJ
ajst-17938	194	17	study	study	NOUN
ajst-17938	194	18	of	of	ADP
ajst-17938	194	19	the	the	DET
ajst-17938	194	20	interaction	interaction	NOUN
ajst-17938	194	21	between	between	ADP
ajst-17938	194	22	naphthalimide	naphthalimide	NOUN
ajst-17938	194	23	polyamine	polyamine	NOUN
ajst-17938	194	24	conjugate	conjugate	NOUN
ajst-17938	194	25	and	and	CCONJ
ajst-17938	194	26	dna	dna	NOUN
ajst-17938	195	1	[	[	X
ajst-17938	195	2	j	j	X
ajst-17938	195	3	]	]	X
ajst-17938	195	4	.	.	PUNCT
ajst-17938	196	1	chemical	chemical	PROPN
ajst-17938	196	2	research	research	PROPN
ajst-17938	196	3	,	,	PUNCT
ajst-17938	196	4	2022	2022	NUM
ajst-17938	196	5	,	,	PUNCT
ajst-17938	196	6	23	23	NUM
ajst-17938	196	7	(	(	PUNCT
ajst-17938	196	8	6	6	NUM
ajst-17938	196	9	):	):	PUNCT
ajst-17938	196	10	4	4	NUM
ajst-17938	196	11	.	.	PUNCT
ajst-17938	197	1	[	[	X
ajst-17938	197	2	21	21	NUM
ajst-17938	197	3	]	]	X
ajst-17938	197	4	ma	ma	PROPN
ajst-17938	197	5	rong	rong	PROPN
ajst-17938	197	6	,	,	PUNCT
ajst-17938	197	7	chen	chen	PROPN
ajst-17938	197	8	yingyu	yingyu	PROPN
ajst-17938	197	9	,	,	PUNCT
ajst-17938	197	10	jiang	jiang	PROPN
ajst-17938	197	11	dongmei	dongmei	PROPN
ajst-17938	197	12	,	,	PUNCT
ajst-17938	197	13	et	et	PROPN
ajst-17938	197	14	al	al	PROPN
ajst-17938	197	15	.	.	PUNCT
ajst-17938	198	1	the	the	DET
ajst-17938	198	2	role	role	NOUN
ajst-17938	198	3	and	and	CCONJ
ajst-17938	198	4	mechanism	mechanism	NOUN
ajst-17938	198	5	of	of	ADP
ajst-17938	198	6	polyamines	polyamine	NOUN
ajst-17938	198	7	in	in	ADP
ajst-17938	198	8	cancer	cancer	NOUN
ajst-17938	198	9	treatment	treatment	NOUN
ajst-17938	198	10	[	[	X
ajst-17938	198	11	j	j	X
ajst-17938	198	12	]	]	X
ajst-17938	198	13	.	.	PUNCT
ajst-17938	199	1	biotechnology	biotechnology	NOUN
ajst-17938	199	2	bulletin	bulletin	NOUN
ajst-17938	199	3	,	,	PUNCT
ajst-17938	199	4	2023	2023	NUM
ajst-17938	199	5	,	,	PUNCT
ajst-17938	199	6	32	32	NUM
ajst-17938	199	7	(	(	PUNCT
ajst-17938	199	8	2	2	NUM
ajst-17938	199	9	):	):	PUNCT
ajst-17938	199	10	5	5	NUM
ajst-17938	199	11	.	.	PUNCT
ajst-17938	200	1	[	[	X
ajst-17938	200	2	22	22	NUM
ajst-17938	200	3	]	]	X
ajst-17938	200	4	ma	ma	PROPN
ajst-17938	200	5	jing	jing	PROPN
ajst-17938	200	6	,	,	PUNCT
ajst-17938	200	7	wang	wang	PROPN
ajst-17938	200	8	jiajia	jiajia	PROPN
ajst-17938	200	9	,	,	PUNCT
ajst-17938	200	10	fang	fang	PROPN
ajst-17938	200	11	dong	dong	PROPN
ajst-17938	200	12	,	,	PUNCT
ajst-17938	200	13	et	et	PROPN
ajst-17938	200	14	al	al	PROPN
ajst-17938	200	15	.	.	PUNCT
ajst-17938	201	1	a	a	DET
ajst-17938	201	2	glycosyl	glycosyl	NOUN
ajst-17938	201	3	modified	modify	VERB
ajst-17938	201	4	naphthalimide	naphthalimide	NOUN
ajst-17938	201	5	polyamine	polyamine	NOUN
ajst-17938	201	6	conjugate	conjugate	NOUN
ajst-17938	201	7	,	,	PUNCT
ajst-17938	201	8	preparation	preparation	NOUN
ajst-17938	201	9	method	method	NOUN
ajst-17938	201	10	and	and	CCONJ
ajst-17938	201	11	application	application	NOUN
ajst-17938	201	12	:	:	PUNCT
ajst-17938	201	13	cn202110165271.2	cn202110165271.2	NUM
ajst-17938	202	1	[	[	X
ajst-17938	202	2	p	p	X
ajst-17938	202	3	]	]	X
ajst-17938	202	4	cn112940059a	cn112940059a	X
ajst-17938	203	1	[	[	X
ajst-17938	203	2	202402	202402	NUM
ajst-17938	203	3	-	-	SYM
ajst-17938	203	4	20	20	NUM
ajst-17938	203	5	]	]	PUNCT
ajst-17938	204	1	[	[	X
ajst-17938	204	2	23	23	NUM
ajst-17938	204	3	]	]	X
ajst-17938	204	4	chen	chen	PROPN
ajst-17938	204	5	bing	bing	PROPN
ajst-17938	204	6	,	,	PUNCT
ajst-17938	204	7	gao	gao	PROPN
ajst-17938	204	8	fan	fan	PROPN
ajst-17938	204	9	,	,	PUNCT
ajst-17938	204	10	zhang	zhang	PROPN
ajst-17938	204	11	shufeng	shufeng	PROPN
ajst-17938	204	12	,	,	PUNCT
ajst-17938	204	13	et	et	PROPN
ajst-17938	204	14	al	al	PROPN
ajst-17938	204	15	.	.	PROPN
ajst-17938	204	16	design	design	NOUN
ajst-17938	204	17	,	,	PUNCT
ajst-17938	204	18	synthesis	synthesis	NOUN
ajst-17938	204	19	,	,	PUNCT
ajst-17938	204	20	and	and	CCONJ
ajst-17938	204	21	anti	anti	ADJ
ajst-17938	204	22	-	-	ADJ
ajst-17938	204	23	tumor	tumor	ADJ
ajst-17938	204	24	activity	activity	NOUN
ajst-17938	204	25	of	of	ADP
ajst-17938	204	26	amphotericin	amphotericin	ADP
ajst-17938	204	27	conjugates	conjugate	NOUN
ajst-17938	204	28	based	base	VERB
ajst-17938	204	29	on	on	ADP
ajst-17938	204	30	tumor	tumor	NOUN
ajst-17938	204	31	cell	cell	NOUN
ajst-17938	204	32	responsive	responsive	ADJ
ajst-17938	204	33	drug	drug	NOUN
ajst-17938	204	34	release	release	NOUN
ajst-17938	204	35	[	[	X
ajst-17938	204	36	j	j	X
ajst-17938	204	37	]	]	X
ajst-17938	204	38	.	.	PUNCT
ajst-17938	205	1	chinese	chinese	ADJ
ajst-17938	205	2	journal	journal	PROPN
ajst-17938	205	3	of	of	ADP
ajst-17938	205	4	pharmaceutical	pharmaceutical	ADJ
ajst-17938	205	5	chemistry	chemistry	NOUN
ajst-17938	205	6	,	,	PUNCT
ajst-17938	205	7	2020	2020	NUM
ajst-17938	205	8	(	(	PUNCT
ajst-17938	205	9	7	7	NUM
ajst-17938	205	10	):	):	PUNCT
ajst-17938	205	11	10	10	NUM
ajst-17938	205	12	.	.	PUNCT
ajst-17938	206	1	[	[	X
ajst-17938	206	2	24	24	NUM
ajst-17938	206	3	]	]	X
ajst-17938	206	4	wang	wang	PROPN
ajst-17938	206	5	yuxia	yuxia	PROPN
ajst-17938	206	6	,	,	PUNCT
ajst-17938	206	7	wang	wang	PROPN
ajst-17938	206	8	chaojie	chaojie	PROPN
ajst-17938	206	9	,	,	PUNCT
ajst-17938	206	10	tian	tian	ADJ
ajst-17938	206	11	runguo	runguo	X
ajst-17938	206	12	,	,	PUNCT
ajst-17938	206	13	et	et	PROPN
ajst-17938	206	14	al	al	PROPN
ajst-17938	206	15	.	.	PROPN
ajst-17938	206	16	benzo	benzo	PROPN
ajst-17938	207	1	[	[	X
ajst-17938	207	2	c	c	X
ajst-17938	207	3	,	,	PUNCT
ajst-17938	207	4	d	d	X
ajst-17938	207	5	]	]	X
ajst-17938	207	6	indole-2	indole-2	NUM
ajst-17938	207	7	(	(	PUNCT
ajst-17938	207	8	h	h	NOUN
ajst-17938	207	9	)	)	PUNCT
ajst-17938	207	10	one	one	NUM
ajst-17938	207	11	polyamine	polyamine	NOUN
ajst-17938	207	12	conjugate	conjugate	NOUN
ajst-17938	207	13	and	and	CCONJ
ajst-17938	207	14	its	its	PRON
ajst-17938	207	15	preparation	preparation	NOUN
ajst-17938	207	16	method	method	NOUN
ajst-17938	207	17	and	and	CCONJ
ajst-17938	207	18	application	application	NOUN
ajst-17938	207	19	:	:	PUNCT
ajst-17938	207	20	cn201710172206.6	cn201710172206.6	X
ajst-17938	208	1	[	[	X
ajst-17938	208	2	p	p	X
ajst-17938	208	3	]	]	X
ajst-17938	208	4	cn201710172206.6	cn201710172206.6	PUNCT
ajst-17938	208	5	[	[	X
ajst-17938	208	6	2024	2024	NUM
ajst-17938	208	7	-	-	SYM
ajst-17938	208	8	02	02	NUM
ajst-17938	208	9	-	-	PUNCT
ajst-17938	208	10	20	20	NUM
ajst-17938	208	11	]	]	PUNCT
ajst-17938	208	12	[	[	X
ajst-17938	208	13	25	25	NUM
ajst-17938	208	14	]	]	X
ajst-17938	208	15	tian	tian	PROPN
ajst-17938	208	16	zhiyong	zhiyong	PROPN
ajst-17938	208	17	,	,	PUNCT
ajst-17938	208	18	wang	wang	PROPN
ajst-17938	208	19	yuxia	yuxia	PROPN
ajst-17938	208	20	,	,	PUNCT
ajst-17938	208	21	zhao	zhao	PROPN
ajst-17938	208	22	zhonghua	zhonghua	PROPN
ajst-17938	208	23	,	,	PUNCT
ajst-17938	208	24	et	et	PROPN
ajst-17938	208	25	al	al	PROPN
ajst-17938	208	26	.	.	PUNCT
ajst-17938	209	1	spectral	spectral	ADJ
ajst-17938	209	2	study	study	NOUN
ajst-17938	209	3	of	of	ADP
ajst-17938	209	4	the	the	DET
ajst-17938	209	5	interaction	interaction	NOUN
ajst-17938	209	6	between	between	ADP
ajst-17938	209	7	naphthalene	naphthalene	NOUN
ajst-17938	209	8	diamine	diamine	NOUN
ajst-17938	209	9	polyamine	polyamine	NOUN
ajst-17938	209	10	conjugate	conjugate	NOUN
ajst-17938	209	11	and	and	CCONJ
ajst-17938	209	12	dna	dna	NOUN
ajst-17938	210	1	[	[	X
ajst-17938	210	2	j	j	X
ajst-17938	210	3	]	]	X
ajst-17938	210	4	.	.	PUNCT
ajst-17938	211	1	journal	journal	PROPN
ajst-17938	211	2	of	of	ADP
ajst-17938	211	3	anhui	anhui	PROPN
ajst-17938	211	4	normal	normal	ADJ
ajst-17938	211	5	university	university	PROPN
ajst-17938	211	6	(	(	PUNCT
ajst-17938	211	7	natural	natural	ADJ
ajst-17938	211	8	science	science	NOUN
ajst-17938	211	9	edition	edition	NOUN
ajst-17938	211	10	)	)	PUNCT
ajst-17938	211	11	,	,	PUNCT
ajst-17938	211	12	2024	2024	NUM
ajst-17938	211	13	,	,	PUNCT
ajst-17938	211	14	037	037	NUM
ajst-17938	211	15	(	(	PUNCT
ajst-17938	211	16	004	004	NUM
ajst-17938	211	17	):	):	PUNCT
ajst-17938	211	18	357	357	NUM
ajst-17938	211	19	-	-	SYM
ajst-17938	211	20	362	362	NUM
ajst-17938	211	21	[	[	X
ajst-17938	211	22	26	26	NUM
ajst-17938	211	23	]	]	X
ajst-17938	211	24	gan	gan	PROPN
ajst-17938	211	25	ying	ying	PROPN
ajst-17938	211	26	,	,	PUNCT
ajst-17938	211	27	he	he	PRON
ajst-17938	211	28	lihua	lihua	PROPN
ajst-17938	211	29	,	,	PUNCT
ajst-17938	211	30	zhang	zhang	PROPN
ajst-17938	211	31	yahong	yahong	PROPN
ajst-17938	211	32	,	,	PUNCT
ajst-17938	211	33	et	et	PROPN
ajst-17938	211	34	al	al	PROPN
ajst-17938	211	35	.	.	PUNCT
ajst-17938	211	36	synthesis	synthesis	NOUN
ajst-17938	211	37	and	and	CCONJ
ajst-17938	211	38	antitumor	antitumor	PROPN
ajst-17938	211	39	cell	cell	NOUN
ajst-17938	211	40	proliferation	proliferation	NOUN
ajst-17938	211	41	activity	activity	NOUN
ajst-17938	211	42	of	of	ADP
ajst-17938	211	43	double	double	ADJ
ajst-17938	211	44	substituted	substitute	VERB
ajst-17938	211	45	anthraquinone	anthraquinone	NOUN
ajst-17938	211	46	polyamine	polyamine	NOUN
ajst-17938	211	47	conjugates	conjugate	NOUN
ajst-17938	211	48	[	[	X
ajst-17938	211	49	j	j	X
ajst-17938	211	50	]	]	X
ajst-17938	211	51	.	.	PUNCT
ajst-17938	212	1	chinese	chinese	ADJ
ajst-17938	212	2	journal	journal	PROPN
ajst-17938	212	3	of	of	ADP
ajst-17938	212	4	pharmaceutical	pharmaceutical	ADJ
ajst-17938	212	5	chemistry	chemistry	NOUN
ajst-17938	212	6	,	,	PUNCT
ajst-17938	212	7	2022	2022	NUM
ajst-17938	212	8	,	,	PUNCT
ajst-17938	212	9	24	24	NUM
ajst-17938	212	10	(	(	PUNCT
ajst-17938	212	11	5	5	NUM
ajst-17938	212	12	):	):	PUNCT
ajst-17938	212	13	6	6	NUM
ajst-17938	212	14	.	.	PUNCT
ajst-17938	213	1	[	[	X
ajst-17938	213	2	27	27	NUM
ajst-17938	213	3	]	]	X
ajst-17938	213	4	li	li	PROPN
ajst-17938	213	5	xiaoliu	xiaoliu	PROPN
ajst-17938	213	6	,	,	PUNCT
ajst-17938	213	7	ma	ma	PROPN
ajst-17938	213	8	donglai	donglai	PROPN
ajst-17938	213	9	,	,	PUNCT
ajst-17938	213	10	yang	yang	PROPN
ajst-17938	213	11	hailong	hailong	PROPN
ajst-17938	213	12	,	,	PUNCT
ajst-17938	213	13	et	et	PROPN
ajst-17938	213	14	al	al	PROPN
ajst-17938	213	15	.	.	PUNCT
ajst-17938	213	16	synthesis	synthesis	PROPN
ajst-17938	213	17	,	,	PUNCT
ajst-17938	213	18	antitumor	antitumor	NOUN
ajst-17938	213	19	activity	activity	NOUN
ajst-17938	213	20	,	,	PUNCT
ajst-17938	213	21	and	and	CCONJ
ajst-17938	213	22	dna	dna	PROPN
ajst-17938	213	23	binding	binding	NOUN
ajst-17938	213	24	of	of	ADP
ajst-17938	213	25	acridine	acridine	ADJ
ajst-17938	213	26	polyamine	polyamine	NOUN
ajst-17938	213	27	conjugates	conjugate	NOUN
ajst-17938	213	28	[	[	X
ajst-17938	213	29	j	j	X
ajst-17938	213	30	]	]	X
ajst-17938	213	31	.	.	PUNCT
ajst-17938	214	1	journal	journal	PROPN
ajst-17938	214	2	of	of	ADP
ajst-17938	214	3	chemistry	chemistry	NOUN
ajst-17938	214	4	,	,	PUNCT
ajst-17938	214	5	higher	high	ADJ
ajst-17938	214	6	education	education	NOUN
ajst-17938	214	7	,	,	PUNCT
ajst-17938	214	8	2014	2014	NUM
ajst-17938	214	9	,	,	PUNCT
ajst-17938	214	10	35	35	NUM
ajst-17938	214	11	(	(	PUNCT
ajst-17938	214	12	6	6	NUM
ajst-17938	214	13	):	):	PUNCT
ajst-17938	214	14	8	8	NUM
ajst-17938	214	15	.	.	PUNCT
ajst-17938	215	1	[	[	X
ajst-17938	215	2	28	28	NUM
ajst-17938	215	3	]	]	X
ajst-17938	215	4	li	li	PROPN
ajst-17938	215	5	xinna	xinna	PROPN
ajst-17938	215	6	.	.	PUNCT
ajst-17938	216	1	targeted	target	VERB
ajst-17938	216	2	lysosomal	lysosomal	ADJ
ajst-17938	216	3	inhibition	inhibition	NOUN
ajst-17938	216	4	of	of	ADP
ajst-17938	216	5	esophageal	esophageal	ADJ
ajst-17938	216	6	squamous	squamous	ADJ
ajst-17938	216	7	cell	cell	NOUN
ajst-17938	216	8	carcinoma	carcinoma	NOUN
ajst-17938	216	9	by	by	ADP
ajst-17938	216	10	naphthalimide	naphthalimide	ADJ
ajst-17938	216	11	polyamine	polyamine	NOUN
ajst-17938	216	12	conjugate	conjugate	NOUN
ajst-17938	216	13	and	and	CCONJ
ajst-17938	216	14	its	its	PRON
ajst-17938	216	15	mechanism	mechanism	NOUN
ajst-17938	217	1	[	[	X
ajst-17938	217	2	d	d	X
ajst-17938	217	3	]	]	X
ajst-17938	217	4	.	.	PUNCT
ajst-17938	218	1	henan	henan	PROPN
ajst-17938	218	2	university	university	PROPN
ajst-17938	219	1	[	[	X
ajst-17938	219	2	2024	2024	NUM
ajst-17938	219	3	-	-	SYM
ajst-17938	219	4	0220	0220	NUM
ajst-17938	219	5	]	]	PUNCT
ajst-17938	220	1	[	[	X
ajst-17938	220	2	29	29	NUM
ajst-17938	220	3	]	]	X
ajst-17938	220	4	jin	jin	PROPN
ajst-17938	220	5	peiyuan	peiyuan	PROPN
ajst-17938	220	6	,	,	PUNCT
ajst-17938	220	7	liu	liu	PROPN
ajst-17938	220	8	kai	kai	PROPN
ajst-17938	220	9	,	,	PUNCT
ajst-17938	220	10	jin	jin	PROPN
ajst-17938	220	11	peng	peng	PROPN
ajst-17938	220	12	,	,	PUNCT
ajst-17938	220	13	et	et	PROPN
ajst-17938	220	14	al	al	PROPN
ajst-17938	220	15	.	.	PUNCT
ajst-17938	220	16	synthesis	synthesis	NOUN
ajst-17938	220	17	of	of	ADP
ajst-17938	220	18	deoxynucleoside	deoxynucleoside	NOUN
ajst-17938	220	19	polyamine	polyamine	NOUN
ajst-17938	220	20	bioconjugates	bioconjugate	NOUN
ajst-17938	220	21	[	[	X
ajst-17938	220	22	c]//25th	c]//25th	X
ajst-17938	220	23	academic	academic	ADJ
ajst-17938	220	24	annual	annual	ADJ
ajst-17938	220	25	meeting	meeting	NOUN
ajst-17938	220	26	of	of	ADP
ajst-17938	220	27	the	the	DET
ajst-17938	220	28	chinese	chinese	ADJ
ajst-17938	220	29	chemical	chemical	PROPN
ajst-17938	220	30	society	society	NOUN
ajst-17938	220	31	[	[	X
ajst-17938	220	32	2024	2024	NUM
ajst-17938	220	33	-	-	SYM
ajst-17938	220	34	02	02	NUM
ajst-17938	220	35	-	-	PUNCT
ajst-17938	220	36	20	20	NUM
ajst-17938	220	37	]	]	PUNCT
ajst-17938	221	1	[	[	X
ajst-17938	221	2	30	30	NUM
ajst-17938	221	3	]	]	X
ajst-17938	221	4	zhao	zhao	PROPN
ajst-17938	221	5	ying	ying	PROPN
ajst-17938	221	6	.	.	PUNCT
ajst-17938	222	1	study	study	NOUN
ajst-17938	222	2	on	on	ADP
ajst-17938	222	3	the	the	DET
ajst-17938	222	4	anti	anti	ADJ
ajst-17938	222	5	-	-	ADJ
ajst-17938	222	6	liver	liver	ADJ
ajst-17938	222	7	cancer	cancer	NOUN
ajst-17938	222	8	effect	effect	NOUN
ajst-17938	222	9	and	and	CCONJ
ajst-17938	222	10	mechanism	mechanism	NOUN
ajst-17938	222	11	of	of	ADP
ajst-17938	222	12	naphthalimide	naphthalimide	ADJ
ajst-17938	222	13	polyamine	polyamine	NOUN
ajst-17938	222	14	conjugate	conjugate	ADJ
ajst-17938	222	15	slp4	slp4	NOUN
ajst-17938	223	1	[	[	X
ajst-17938	223	2	d	d	X
ajst-17938	223	3	]	]	X
ajst-17938	223	4	.	.	PUNCT
ajst-17938	224	1	henan	henan	PROPN
ajst-17938	224	2	university	university	PROPN
ajst-17938	225	1	[	[	X
ajst-17938	225	2	2024	2024	NUM
ajst-17938	225	3	-	-	SYM
ajst-17938	225	4	02	02	NUM
ajst-17938	225	5	-	-	PUNCT
ajst-17938	225	6	20	20	NUM
ajst-17938	225	7	]	]	PUNCT