id	sid	tid	token	lemma	pos
ajst-19178	1	1	academic	academic	ADJ
ajst-19178	1	2	journal	journal	NOUN
ajst-19178	1	3	of	of	ADP
ajst-19178	1	4	science	science	NOUN
ajst-19178	1	5	and	and	CCONJ
ajst-19178	1	6	technology	technology	NOUN
ajst-19178	1	7	issn	issn	NOUN
ajst-19178	1	8	:	:	PUNCT
ajst-19178	1	9	2771	2771	NUM
ajst-19178	1	10	-	-	SYM
ajst-19178	1	11	3032	3032	NUM
ajst-19178	1	12	|	|	NOUN
ajst-19178	1	13	vol	vol	NOUN
ajst-19178	1	14	.	.	PROPN
ajst-19178	2	1	10	10	NUM
ajst-19178	2	2	,	,	PUNCT
ajst-19178	2	3	no	no	INTJ
ajst-19178	2	4	.	.	NOUN
ajst-19178	2	5	1	1	NUM
ajst-19178	2	6	,	,	PUNCT
ajst-19178	2	7	2024	2024	NUM
ajst-19178	2	8	197	197	NUM
ajst-19178	2	9	research	research	NOUN
ajst-19178	2	10	progress	progress	NOUN
ajst-19178	2	11	on	on	ADP
ajst-19178	2	12	anti‐tumor	anti‐tumor	NOUN
ajst-19178	2	13	mechanism	mechanism	NOUN
ajst-19178	2	14	of	of	ADP
ajst-19178	2	15	artesunate	artesunate	ADJ
ajst-19178	2	16	combined	combine	VERB
ajst-19178	2	17	drugs	drug	NOUN
ajst-19178	2	18	mengting	mengte	VERB
ajst-19178	2	19	shi	shi	PROPN
ajst-19178	2	20	,	,	PUNCT
ajst-19178	2	21	xiulan	xiulan	PROPN
ajst-19178	2	22	yang	yang	PROPN
ajst-19178	2	23	*	*	PROPN
ajst-19178	2	24	department	department	PROPN
ajst-19178	2	25	of	of	ADP
ajst-19178	2	26	pharmacology	pharmacology	NOUN
ajst-19178	2	27	,	,	PUNCT
ajst-19178	2	28	the	the	DET
ajst-19178	2	29	school	school	NOUN
ajst-19178	2	30	of	of	ADP
ajst-19178	2	31	basic	basic	ADJ
ajst-19178	2	32	medicine	medicine	NOUN
ajst-19178	2	33	,	,	PUNCT
ajst-19178	2	34	health	health	NOUN
ajst-19178	2	35	science	science	NOUN
ajst-19178	2	36	center	center	PROPN
ajst-19178	2	37	,	,	PUNCT
ajst-19178	2	38	yangtze	yangtze	PROPN
ajst-19178	2	39	university	university	PROPN
ajst-19178	2	40	,	,	PUNCT
ajst-19178	2	41	jingzhou	jingzhou	PROPN
ajst-19178	2	42	434023	434023	NUM
ajst-19178	2	43	,	,	PUNCT
ajst-19178	2	44	china	china	PROPN
ajst-19178	2	45	*	*	PUNCT
ajst-19178	2	46	corresponding	correspond	VERB
ajst-19178	2	47	author	author	NOUN
ajst-19178	2	48	abstract	abstract	NOUN
ajst-19178	2	49	:	:	PUNCT
ajst-19178	2	50	artesunate	artesunate	NOUN
ajst-19178	2	51	(	(	PUNCT
ajst-19178	2	52	art	art	NOUN
ajst-19178	2	53	)	)	PUNCT
ajst-19178	2	54	is	be	AUX
ajst-19178	2	55	a	a	DET
ajst-19178	2	56	semi	semi	ADJ
ajst-19178	2	57	-	-	ADJ
ajst-19178	2	58	synthetic	synthetic	ADJ
ajst-19178	2	59	artemisinin	artemisinin	NOUN
ajst-19178	2	60	derivative	derivative	NOUN
ajst-19178	2	61	of	of	ADP
ajst-19178	2	62	hemiterpene	hemiterpene	ADJ
ajst-19178	2	63	lactones	lactone	NOUN
ajst-19178	2	64	,	,	PUNCT
ajst-19178	2	65	which	which	PRON
ajst-19178	2	66	is	be	AUX
ajst-19178	2	67	widely	widely	ADV
ajst-19178	2	68	used	use	VERB
ajst-19178	2	69	in	in	ADP
ajst-19178	2	70	clinical	clinical	ADJ
ajst-19178	2	71	antimalarial	antimalarial	ADJ
ajst-19178	2	72	therapy	therapy	NOUN
ajst-19178	2	73	.	.	PUNCT
ajst-19178	3	1	in	in	ADP
ajst-19178	3	2	recent	recent	ADJ
ajst-19178	3	3	years	year	NOUN
ajst-19178	3	4	,	,	PUNCT
ajst-19178	3	5	studies	study	NOUN
ajst-19178	3	6	have	have	AUX
ajst-19178	3	7	shown	show	VERB
ajst-19178	3	8	that	that	DET
ajst-19178	3	9	artesunate	artesunate	NOUN
ajst-19178	3	10	also	also	ADV
ajst-19178	3	11	has	have	VERB
ajst-19178	3	12	anti	anti	ADJ
ajst-19178	3	13	-	-	ADJ
ajst-19178	3	14	inflammatory	inflammatory	ADJ
ajst-19178	3	15	,	,	PUNCT
ajst-19178	3	16	anti	anti	ADJ
ajst-19178	3	17	-	-	ADJ
ajst-19178	3	18	tumor	tumor	ADJ
ajst-19178	3	19	,	,	PUNCT
ajst-19178	3	20	anti	anti	ADJ
ajst-19178	3	21	-	-	ADJ
ajst-19178	3	22	fibrosis	fibrosis	ADJ
ajst-19178	3	23	,	,	PUNCT
ajst-19178	3	24	antiviral	antiviral	ADJ
ajst-19178	3	25	,	,	PUNCT
ajst-19178	3	26	antibacterial	antibacterial	ADJ
ajst-19178	3	27	,	,	PUNCT
ajst-19178	3	28	immunomodulatory	immunomodulatory	ADJ
ajst-19178	3	29	and	and	CCONJ
ajst-19178	3	30	other	other	ADJ
ajst-19178	3	31	pharmacological	pharmacological	ADJ
ajst-19178	3	32	activities	activity	NOUN
ajst-19178	3	33	.	.	PUNCT
ajst-19178	4	1	artesunate	artesunate	NOUN
ajst-19178	4	2	can	can	AUX
ajst-19178	4	3	play	play	VERB
ajst-19178	4	4	an	an	DET
ajst-19178	4	5	anti	anti	ADJ
ajst-19178	4	6	-	-	ADJ
ajst-19178	4	7	tumor	tumor	ADJ
ajst-19178	4	8	role	role	NOUN
ajst-19178	4	9	by	by	ADP
ajst-19178	4	10	inhibiting	inhibit	VERB
ajst-19178	4	11	tumor	tumor	NOUN
ajst-19178	4	12	cell	cell	NOUN
ajst-19178	4	13	proliferation	proliferation	NOUN
ajst-19178	4	14	,	,	PUNCT
ajst-19178	4	15	invasion	invasion	NOUN
ajst-19178	4	16	and	and	CCONJ
ajst-19178	4	17	migration	migration	NOUN
ajst-19178	4	18	,	,	PUNCT
ajst-19178	4	19	promoting	promote	VERB
ajst-19178	4	20	tumor	tumor	NOUN
ajst-19178	4	21	cell	cell	NOUN
ajst-19178	4	22	apoptosis	apoptosis	NOUN
ajst-19178	4	23	and	and	CCONJ
ajst-19178	4	24	blocking	block	VERB
ajst-19178	4	25	cell	cell	NOUN
ajst-19178	4	26	cycle	cycle	NOUN
ajst-19178	4	27	.	.	PUNCT
ajst-19178	5	1	at	at	ADP
ajst-19178	5	2	the	the	DET
ajst-19178	5	3	same	same	ADJ
ajst-19178	5	4	time	time	NOUN
ajst-19178	5	5	,	,	PUNCT
ajst-19178	5	6	when	when	SCONJ
ajst-19178	5	7	combined	combine	VERB
ajst-19178	5	8	with	with	ADP
ajst-19178	5	9	other	other	ADJ
ajst-19178	5	10	anti	anti	ADJ
ajst-19178	5	11	-	-	ADJ
ajst-19178	5	12	tumor	tumor	ADJ
ajst-19178	5	13	drugs	drug	NOUN
ajst-19178	5	14	,	,	PUNCT
ajst-19178	5	15	it	it	PRON
ajst-19178	5	16	can	can	AUX
ajst-19178	5	17	enhance	enhance	VERB
ajst-19178	5	18	the	the	DET
ajst-19178	5	19	anti	anti	ADJ
ajst-19178	5	20	-	-	ADJ
ajst-19178	5	21	tumor	tumor	ADJ
ajst-19178	5	22	efficacy	efficacy	NOUN
ajst-19178	5	23	,	,	PUNCT
ajst-19178	5	24	shorten	shorten	VERB
ajst-19178	5	25	the	the	DET
ajst-19178	5	26	duration	duration	NOUN
ajst-19178	5	27	of	of	ADP
ajst-19178	5	28	administration	administration	NOUN
ajst-19178	5	29	,	,	PUNCT
ajst-19178	5	30	reduce	reduce	VERB
ajst-19178	5	31	the	the	DET
ajst-19178	5	32	dose	dose	NOUN
ajst-19178	5	33	and	and	CCONJ
ajst-19178	5	34	adverse	adverse	ADJ
ajst-19178	5	35	reactions	reaction	NOUN
ajst-19178	5	36	.	.	PUNCT
ajst-19178	6	1	in	in	ADP
ajst-19178	6	2	this	this	DET
ajst-19178	6	3	paper	paper	NOUN
ajst-19178	6	4	,	,	PUNCT
ajst-19178	6	5	the	the	DET
ajst-19178	6	6	main	main	ADJ
ajst-19178	6	7	keywords	keyword	NOUN
ajst-19178	6	8	of	of	ADP
ajst-19178	6	9	"	"	PUNCT
ajst-19178	6	10	artesunate	artesunate	NOUN
ajst-19178	6	11	"	"	PUNCT
ajst-19178	6	12	,	,	PUNCT
ajst-19178	6	13	"	"	PUNCT
ajst-19178	6	14	pharmacology	pharmacology	NOUN
ajst-19178	6	15	"	"	PUNCT
ajst-19178	6	16	,	,	PUNCT
ajst-19178	6	17	"	"	PUNCT
ajst-19178	6	18	anti	anti	ADJ
ajst-19178	6	19	-	-	ADJ
ajst-19178	6	20	tumor	tumor	ADJ
ajst-19178	6	21	"	"	PUNCT
ajst-19178	6	22	and	and	CCONJ
ajst-19178	6	23	"	"	PUNCT
ajst-19178	6	24	combined	combined	ADJ
ajst-19178	6	25	drug	drug	NOUN
ajst-19178	6	26	"	"	PUNCT
ajst-19178	6	27	were	be	AUX
ajst-19178	6	28	searched	search	VERB
ajst-19178	6	29	and	and	CCONJ
ajst-19178	6	30	integrated	integrate	VERB
ajst-19178	6	31	in	in	ADP
ajst-19178	6	32	pubmed	pubmed	PROPN
ajst-19178	6	33	,	,	PUNCT
ajst-19178	6	34	web	web	NOUN
ajst-19178	6	35	of	of	ADP
ajst-19178	6	36	science	science	NOUN
ajst-19178	6	37	and	and	CCONJ
ajst-19178	6	38	cnki	cnki	ADJ
ajst-19178	6	39	electronic	electronic	ADJ
ajst-19178	6	40	databases	database	NOUN
ajst-19178	6	41	to	to	PART
ajst-19178	6	42	review	review	VERB
ajst-19178	6	43	the	the	DET
ajst-19178	6	44	antitumor	antitumor	PROPN
ajst-19178	6	45	mechanism	mechanism	NOUN
ajst-19178	6	46	of	of	ADP
ajst-19178	6	47	artesunate	artesunate	NOUN
ajst-19178	6	48	combined	combine	VERB
ajst-19178	6	49	with	with	ADP
ajst-19178	6	50	other	other	ADJ
ajst-19178	6	51	drugs	drug	NOUN
ajst-19178	6	52	in	in	ADP
ajst-19178	6	53	recent	recent	ADJ
ajst-19178	6	54	5	5	NUM
ajst-19178	6	55	years	year	NOUN
ajst-19178	6	56	.	.	PUNCT
ajst-19178	7	1	the	the	DET
ajst-19178	7	2	prospect	prospect	NOUN
ajst-19178	7	3	of	of	ADP
ajst-19178	7	4	clinical	clinical	ADJ
ajst-19178	7	5	application	application	NOUN
ajst-19178	7	6	of	of	ADP
ajst-19178	7	7	artesunate	artesunate	NOUN
ajst-19178	7	8	as	as	ADP
ajst-19178	7	9	an	an	DET
ajst-19178	7	10	antitumor	antitumor	PROPN
ajst-19178	7	11	drug	drug	NOUN
ajst-19178	7	12	was	be	AUX
ajst-19178	7	13	prospected	prospect	VERB
ajst-19178	7	14	to	to	PART
ajst-19178	7	15	provide	provide	VERB
ajst-19178	7	16	some	some	DET
ajst-19178	7	17	theoretical	theoretical	ADJ
ajst-19178	7	18	basis	basis	NOUN
ajst-19178	7	19	for	for	ADP
ajst-19178	7	20	further	further	ADJ
ajst-19178	7	21	rational	rational	ADJ
ajst-19178	7	22	development	development	NOUN
ajst-19178	7	23	and	and	CCONJ
ajst-19178	7	24	utilization	utilization	NOUN
ajst-19178	7	25	of	of	ADP
ajst-19178	7	26	artesunate	artesunate	ADJ
ajst-19178	7	27	and	and	CCONJ
ajst-19178	7	28	new	new	ADJ
ajst-19178	7	29	drug	drug	NOUN
ajst-19178	7	30	research	research	NOUN
ajst-19178	7	31	and	and	CCONJ
ajst-19178	7	32	development	development	NOUN
ajst-19178	7	33	.	.	PUNCT
ajst-19178	8	1	keywords	keyword	NOUN
ajst-19178	8	2	:	:	PUNCT
ajst-19178	8	3	artesunate	artesunate	VERB
ajst-19178	8	4	;	;	PUNCT
ajst-19178	8	5	anti	anti	ADJ
ajst-19178	8	6	-	-	ADJ
ajst-19178	8	7	tumor	tumor	ADJ
ajst-19178	8	8	;	;	PUNCT
ajst-19178	8	9	drug	drug	NOUN
ajst-19178	8	10	combination	combination	NOUN
ajst-19178	8	11	;	;	PUNCT
ajst-19178	8	12	action	action	NOUN
ajst-19178	8	13	mechanism	mechanism	NOUN
ajst-19178	8	14	.	.	PUNCT
ajst-19178	9	1	1	1	X
ajst-19178	9	2	.	.	X
ajst-19178	9	3	introduction	introduction	NOUN
ajst-19178	9	4	cancer	cancer	NOUN
ajst-19178	9	5	is	be	AUX
ajst-19178	9	6	a	a	DET
ajst-19178	9	7	major	major	ADJ
ajst-19178	9	8	global	global	ADJ
ajst-19178	9	9	public	public	ADJ
ajst-19178	9	10	health	health	NOUN
ajst-19178	9	11	problem	problem	NOUN
ajst-19178	9	12	and	and	CCONJ
ajst-19178	9	13	a	a	DET
ajst-19178	9	14	major	major	ADJ
ajst-19178	9	15	contributor	contributor	NOUN
ajst-19178	9	16	to	to	ADP
ajst-19178	9	17	the	the	DET
ajst-19178	9	18	global	global	ADJ
ajst-19178	9	19	disease	disease	NOUN
ajst-19178	9	20	burden	burden	VERB
ajst-19178	9	21	due	due	ADP
ajst-19178	9	22	to	to	ADP
ajst-19178	9	23	its	its	PRON
ajst-19178	9	24	high	high	ADJ
ajst-19178	9	25	morbidity	morbidity	NOUN
ajst-19178	9	26	and	and	CCONJ
ajst-19178	9	27	mortality	mortality	NOUN
ajst-19178	10	1	[	[	X
ajst-19178	10	2	1	1	NUM
ajst-19178	10	3	-	-	SYM
ajst-19178	10	4	3	3	NUM
ajst-19178	10	5	]	]	PUNCT
ajst-19178	10	6	.	.	PUNCT
ajst-19178	11	1	at	at	ADP
ajst-19178	11	2	present	present	ADJ
ajst-19178	11	3	,	,	PUNCT
ajst-19178	11	4	surgical	surgical	ADJ
ajst-19178	11	5	treatment	treatment	NOUN
ajst-19178	11	6	,	,	PUNCT
ajst-19178	11	7	chemotherapy	chemotherapy	NOUN
ajst-19178	11	8	,	,	PUNCT
ajst-19178	11	9	radiotherapy	radiotherapy	NOUN
ajst-19178	11	10	,	,	PUNCT
ajst-19178	11	11	targeted	target	VERB
ajst-19178	11	12	therapy	therapy	NOUN
ajst-19178	11	13	,	,	PUNCT
ajst-19178	11	14	immunotherapy	immunotherapy	NOUN
ajst-19178	11	15	and	and	CCONJ
ajst-19178	11	16	other	other	ADJ
ajst-19178	11	17	methods	method	NOUN
ajst-19178	11	18	are	be	AUX
ajst-19178	11	19	mainly	mainly	ADV
ajst-19178	11	20	used	use	VERB
ajst-19178	11	21	in	in	ADP
ajst-19178	11	22	the	the	DET
ajst-19178	11	23	clinical	clinical	ADJ
ajst-19178	11	24	treatment	treatment	NOUN
ajst-19178	11	25	of	of	ADP
ajst-19178	11	26	cancer	cancer	NOUN
ajst-19178	11	27	[	[	X
ajst-19178	11	28	4	4	NUM
ajst-19178	11	29	-	-	SYM
ajst-19178	11	30	7	7	NUM
ajst-19178	11	31	]	]	PUNCT
ajst-19178	11	32	,	,	PUNCT
ajst-19178	11	33	but	but	CCONJ
ajst-19178	11	34	chemotherapy	chemotherapy	NOUN
ajst-19178	11	35	drugs	drug	NOUN
ajst-19178	11	36	will	will	AUX
ajst-19178	11	37	have	have	VERB
ajst-19178	11	38	adverse	adverse	ADJ
ajst-19178	11	39	effects	effect	NOUN
ajst-19178	11	40	on	on	ADP
ajst-19178	11	41	liver	liver	NOUN
ajst-19178	11	42	and	and	CCONJ
ajst-19178	11	43	kidney	kidney	NOUN
ajst-19178	11	44	function	function	NOUN
ajst-19178	11	45	,	,	PUNCT
ajst-19178	11	46	and	and	CCONJ
ajst-19178	11	47	there	there	PRON
ajst-19178	11	48	is	be	VERB
ajst-19178	11	49	a	a	DET
ajst-19178	11	50	large	large	ADJ
ajst-19178	11	51	difference	difference	NOUN
ajst-19178	11	52	between	between	ADP
ajst-19178	11	53	individuals	individual	NOUN
ajst-19178	11	54	treated	treat	VERB
ajst-19178	11	55	with	with	ADP
ajst-19178	11	56	drugs	drug	NOUN
ajst-19178	11	57	,	,	PUNCT
ajst-19178	11	58	which	which	PRON
ajst-19178	11	59	is	be	AUX
ajst-19178	11	60	prone	prone	ADJ
ajst-19178	11	61	to	to	ADP
ajst-19178	11	62	drug	drug	NOUN
ajst-19178	11	63	resistance	resistance	NOUN
ajst-19178	11	64	and	and	CCONJ
ajst-19178	11	65	poor	poor	ADJ
ajst-19178	11	66	prognosis	prognosis	NOUN
ajst-19178	11	67	,	,	PUNCT
ajst-19178	11	68	so	so	CCONJ
ajst-19178	11	69	it	it	PRON
ajst-19178	11	70	is	be	AUX
ajst-19178	11	71	necessary	necessary	ADJ
ajst-19178	11	72	to	to	PART
ajst-19178	11	73	find	find	VERB
ajst-19178	11	74	safer	safe	ADJ
ajst-19178	11	75	and	and	CCONJ
ajst-19178	11	76	effective	effective	ADJ
ajst-19178	11	77	anti	anti	ADJ
ajst-19178	11	78	-	-	ADJ
ajst-19178	11	79	tumor	tumor	ADJ
ajst-19178	11	80	drugs	drug	NOUN
ajst-19178	11	81	.	.	PUNCT
ajst-19178	12	1	art	art	NOUN
ajst-19178	12	2	is	be	AUX
ajst-19178	12	3	a	a	DET
ajst-19178	12	4	derivative	derivative	NOUN
ajst-19178	12	5	of	of	ADP
ajst-19178	12	6	artemisinin	artemisinin	NOUN
ajst-19178	12	7	,	,	PUNCT
ajst-19178	12	8	which	which	PRON
ajst-19178	12	9	has	have	VERB
ajst-19178	12	10	the	the	DET
ajst-19178	12	11	characteristics	characteristic	NOUN
ajst-19178	12	12	of	of	ADP
ajst-19178	12	13	rapid	rapid	ADJ
ajst-19178	12	14	action	action	NOUN
ajst-19178	12	15	,	,	PUNCT
ajst-19178	12	16	low	low	ADJ
ajst-19178	12	17	toxicity	toxicity	NOUN
ajst-19178	12	18	and	and	CCONJ
ajst-19178	12	19	resistance[8	resistance[8	NOUN
ajst-19178	12	20	]	]	PUNCT
ajst-19178	12	21	.	.	PUNCT
ajst-19178	13	1	in	in	ADP
ajst-19178	13	2	addition	addition	NOUN
ajst-19178	13	3	to	to	ADP
ajst-19178	13	4	its	its	PRON
ajst-19178	13	5	pharmacological	pharmacological	ADJ
ajst-19178	13	6	effects	effect	NOUN
ajst-19178	13	7	of	of	ADP
ajst-19178	13	8	anti	anti	ADJ
ajst-19178	13	9	-	-	ADJ
ajst-19178	13	10	malaria	malaria	ADJ
ajst-19178	13	11	,	,	PUNCT
ajst-19178	13	12	antiinflammation	antiinflammation	NOUN
ajst-19178	13	13	,	,	PUNCT
ajst-19178	13	14	anti	anti	ADJ
ajst-19178	13	15	-	-	NOUN
ajst-19178	13	16	virus	virus	NOUN
ajst-19178	13	17	and	and	CCONJ
ajst-19178	13	18	anti	anti	ADJ
ajst-19178	13	19	-	-	ADJ
ajst-19178	13	20	fibrosis	fibrosis	ADJ
ajst-19178	13	21	,	,	PUNCT
ajst-19178	13	22	art	art	NOUN
ajst-19178	13	23	has	have	AUX
ajst-19178	13	24	also	also	ADV
ajst-19178	13	25	been	be	AUX
ajst-19178	13	26	widely	widely	ADV
ajst-19178	13	27	used	use	VERB
ajst-19178	13	28	in	in	ADP
ajst-19178	13	29	anti	anti	ADJ
ajst-19178	13	30	-	-	ADJ
ajst-19178	13	31	tumor	tumor	ADJ
ajst-19178	13	32	.	.	PUNCT
ajst-19178	14	1	many	many	ADJ
ajst-19178	14	2	studies	study	NOUN
ajst-19178	14	3	have	have	AUX
ajst-19178	14	4	shown	show	VERB
ajst-19178	14	5	that	that	SCONJ
ajst-19178	14	6	art	art	NOUN
ajst-19178	14	7	can	can	AUX
ajst-19178	14	8	be	be	AUX
ajst-19178	14	9	used	use	VERB
ajst-19178	14	10	in	in	ADP
ajst-19178	14	11	the	the	DET
ajst-19178	14	12	treatment	treatment	NOUN
ajst-19178	14	13	of	of	ADP
ajst-19178	14	14	gastric	gastric	ADJ
ajst-19178	14	15	cancer	cancer	NOUN
ajst-19178	14	16	,	,	PUNCT
ajst-19178	14	17	liver	liver	NOUN
ajst-19178	14	18	cancer	cancer	NOUN
ajst-19178	14	19	,	,	PUNCT
ajst-19178	14	20	breast	breast	NOUN
ajst-19178	14	21	cancer	cancer	NOUN
ajst-19178	14	22	,	,	PUNCT
ajst-19178	14	23	colorectal	colorectal	ADJ
ajst-19178	14	24	cancer	cancer	NOUN
ajst-19178	14	25	and	and	CCONJ
ajst-19178	14	26	other	other	ADJ
ajst-19178	14	27	cancers	cancer	NOUN
ajst-19178	14	28	,	,	PUNCT
ajst-19178	14	29	and	and	CCONJ
ajst-19178	14	30	has	have	VERB
ajst-19178	14	31	significant	significant	ADJ
ajst-19178	14	32	therapeutic	therapeutic	ADJ
ajst-19178	14	33	effect	effect	NOUN
ajst-19178	14	34	.	.	PUNCT
ajst-19178	15	1	art	art	NOUN
ajst-19178	15	2	can	can	AUX
ajst-19178	15	3	specifically	specifically	ADV
ajst-19178	15	4	inhibit	inhibit	VERB
ajst-19178	15	5	the	the	DET
ajst-19178	15	6	growth	growth	NOUN
ajst-19178	15	7	of	of	ADP
ajst-19178	15	8	cancer	cancer	NOUN
ajst-19178	15	9	cells	cell	NOUN
ajst-19178	15	10	and	and	CCONJ
ajst-19178	15	11	exert	exert	VERB
ajst-19178	15	12	anti	anti	ADJ
ajst-19178	15	13	-	-	ADJ
ajst-19178	15	14	tumor	tumor	ADJ
ajst-19178	15	15	effects	effect	NOUN
ajst-19178	15	16	by	by	ADP
ajst-19178	15	17	inhibiting	inhibit	VERB
ajst-19178	15	18	angiogenesis	angiogenesis	NOUN
ajst-19178	15	19	,	,	PUNCT
ajst-19178	15	20	inhibiting	inhibit	VERB
ajst-19178	15	21	the	the	DET
ajst-19178	15	22	invasion	invasion	NOUN
ajst-19178	15	23	and	and	CCONJ
ajst-19178	15	24	migration	migration	NOUN
ajst-19178	15	25	of	of	ADP
ajst-19178	15	26	cancer	cancer	NOUN
ajst-19178	15	27	cells	cell	NOUN
ajst-19178	15	28	,	,	PUNCT
ajst-19178	15	29	inducing	induce	VERB
ajst-19178	15	30	cell	cell	NOUN
ajst-19178	15	31	cycle	cycle	NOUN
ajst-19178	15	32	arrest	arrest	NOUN
ajst-19178	15	33	,	,	PUNCT
ajst-19178	15	34	and	and	CCONJ
ajst-19178	15	35	regulating	regulate	VERB
ajst-19178	15	36	signal	signal	NOUN
ajst-19178	15	37	transduction	transduction	NOUN
ajst-19178	16	1	[	[	X
ajst-19178	16	2	9	9	NUM
ajst-19178	16	3	-	-	SYM
ajst-19178	16	4	12	12	NUM
ajst-19178	16	5	]	]	PUNCT
ajst-19178	16	6	.	.	PUNCT
ajst-19178	17	1	the	the	DET
ajst-19178	17	2	generation	generation	NOUN
ajst-19178	17	3	of	of	ADP
ajst-19178	17	4	drug	drug	NOUN
ajst-19178	17	5	resistance	resistance	NOUN
ajst-19178	17	6	and	and	CCONJ
ajst-19178	17	7	the	the	DET
ajst-19178	17	8	accumulation	accumulation	NOUN
ajst-19178	17	9	of	of	ADP
ajst-19178	17	10	dose	dose	NOUN
ajst-19178	17	11	-	-	PUNCT
ajst-19178	17	12	related	relate	VERB
ajst-19178	17	13	toxicity	toxicity	NOUN
ajst-19178	17	14	are	be	AUX
ajst-19178	17	15	the	the	DET
ajst-19178	17	16	main	main	ADJ
ajst-19178	17	17	shortcomings	shortcoming	NOUN
ajst-19178	17	18	of	of	ADP
ajst-19178	17	19	chemotherapy	chemotherapy	NOUN
ajst-19178	17	20	drugs	drug	NOUN
ajst-19178	17	21	in	in	ADP
ajst-19178	17	22	the	the	DET
ajst-19178	17	23	treatment	treatment	NOUN
ajst-19178	17	24	of	of	ADP
ajst-19178	17	25	cancer	cancer	NOUN
ajst-19178	17	26	.	.	PUNCT
ajst-19178	18	1	therefore	therefore	ADV
ajst-19178	18	2	,	,	PUNCT
ajst-19178	18	3	it	it	PRON
ajst-19178	18	4	is	be	AUX
ajst-19178	18	5	necessary	necessary	ADJ
ajst-19178	18	6	to	to	PART
ajst-19178	18	7	find	find	VERB
ajst-19178	18	8	drugs	drug	NOUN
ajst-19178	18	9	that	that	PRON
ajst-19178	18	10	can	can	AUX
ajst-19178	18	11	improve	improve	VERB
ajst-19178	18	12	efficiency	efficiency	NOUN
ajst-19178	18	13	and	and	CCONJ
ajst-19178	18	14	reduce	reduce	VERB
ajst-19178	18	15	toxicity	toxicity	NOUN
ajst-19178	18	16	in	in	ADP
ajst-19178	18	17	dealing	deal	VERB
ajst-19178	18	18	with	with	ADP
ajst-19178	18	19	drug	drug	NOUN
ajst-19178	18	20	resistance	resistance	NOUN
ajst-19178	18	21	,	,	PUNCT
ajst-19178	18	22	and	and	CCONJ
ajst-19178	18	23	the	the	DET
ajst-19178	18	24	combination	combination	NOUN
ajst-19178	18	25	of	of	ADP
ajst-19178	18	26	drugs	drug	NOUN
ajst-19178	18	27	can	can	AUX
ajst-19178	18	28	enhance	enhance	VERB
ajst-19178	18	29	the	the	DET
ajst-19178	18	30	therapeutic	therapeutic	ADJ
ajst-19178	18	31	effect	effect	NOUN
ajst-19178	18	32	of	of	ADP
ajst-19178	18	33	each	each	DET
ajst-19178	18	34	other	other	ADJ
ajst-19178	18	35	,	,	PUNCT
ajst-19178	18	36	prevent	prevent	VERB
ajst-19178	18	37	the	the	DET
ajst-19178	18	38	occurrence	occurrence	NOUN
ajst-19178	18	39	of	of	ADP
ajst-19178	18	40	drug	drug	NOUN
ajst-19178	18	41	resistance	resistance	NOUN
ajst-19178	18	42	,	,	PUNCT
ajst-19178	18	43	reduce	reduce	VERB
ajst-19178	18	44	the	the	DET
ajst-19178	18	45	dose	dose	NOUN
ajst-19178	18	46	used	use	VERB
ajst-19178	18	47	in	in	ADP
ajst-19178	18	48	each	each	DET
ajst-19178	18	49	single	single	ADJ
ajst-19178	18	50	treatment	treatment	NOUN
ajst-19178	18	51	and	and	CCONJ
ajst-19178	18	52	reduce	reduce	VERB
ajst-19178	18	53	the	the	DET
ajst-19178	18	54	adverse	adverse	ADJ
ajst-19178	18	55	reactions	reaction	NOUN
ajst-19178	18	56	of	of	ADP
ajst-19178	18	57	chemotherapy	chemotherapy	NOUN
ajst-19178	18	58	drugs	drug	NOUN
ajst-19178	18	59	and	and	CCONJ
ajst-19178	18	60	molecular	molecular	ADJ
ajst-19178	18	61	targeted	target	VERB
ajst-19178	18	62	drugs	drug	NOUN
ajst-19178	18	63	.	.	PUNCT
ajst-19178	19	1	this	this	DET
ajst-19178	19	2	review	review	NOUN
ajst-19178	19	3	aims	aim	VERB
ajst-19178	19	4	to	to	PART
ajst-19178	19	5	provide	provide	VERB
ajst-19178	19	6	a	a	DET
ajst-19178	19	7	theoretical	theoretical	ADJ
ajst-19178	19	8	basis	basis	NOUN
ajst-19178	19	9	for	for	ADP
ajst-19178	19	10	the	the	DET
ajst-19178	19	11	further	further	ADJ
ajst-19178	19	12	development	development	NOUN
ajst-19178	19	13	of	of	ADP
ajst-19178	19	14	art	art	NOUN
ajst-19178	19	15	combined	combine	VERB
ajst-19178	19	16	therapy	therapy	NOUN
ajst-19178	19	17	by	by	ADP
ajst-19178	19	18	summarizing	summarize	VERB
ajst-19178	19	19	the	the	DET
ajst-19178	19	20	anti	anti	ADJ
ajst-19178	19	21	-	-	ADJ
ajst-19178	19	22	tumor	tumor	ADJ
ajst-19178	19	23	mechanism	mechanism	NOUN
ajst-19178	19	24	of	of	ADP
ajst-19178	19	25	art	art	NOUN
ajst-19178	19	26	combined	combine	VERB
ajst-19178	19	27	with	with	ADP
ajst-19178	19	28	other	other	ADJ
ajst-19178	19	29	drugs	drug	NOUN
ajst-19178	19	30	,	,	PUNCT
ajst-19178	19	31	alleviating	alleviate	VERB
ajst-19178	19	32	pain	pain	NOUN
ajst-19178	19	33	for	for	ADP
ajst-19178	19	34	patients	patient	NOUN
ajst-19178	19	35	,	,	PUNCT
ajst-19178	19	36	and	and	CCONJ
ajst-19178	19	37	providing	provide	VERB
ajst-19178	19	38	certain	certain	ADJ
ajst-19178	19	39	ideas	idea	NOUN
ajst-19178	19	40	for	for	ADP
ajst-19178	19	41	the	the	DET
ajst-19178	19	42	research	research	NOUN
ajst-19178	19	43	and	and	CCONJ
ajst-19178	19	44	development	development	NOUN
ajst-19178	19	45	of	of	ADP
ajst-19178	19	46	new	new	ADJ
ajst-19178	19	47	drugs	drug	NOUN
ajst-19178	19	48	.	.	PUNCT
ajst-19178	20	1	2	2	X
ajst-19178	20	2	.	.	X
ajst-19178	20	3	artesunate	artesunate	ADJ
ajst-19178	20	4	combination	combination	NOUN
ajst-19178	20	5	2.1	2.1	NUM
ajst-19178	20	6	.	.	PUNCT
ajst-19178	21	1	alkylating	alkylate	VERB
ajst-19178	21	2	agents	agent	NOUN
ajst-19178	21	3	alkylating	alkylate	VERB
ajst-19178	21	4	agents	agent	NOUN
ajst-19178	21	5	[	[	X
ajst-19178	21	6	13	13	NUM
ajst-19178	21	7	-	-	SYM
ajst-19178	21	8	14	14	NUM
ajst-19178	21	9	]	]	PUNCT
ajst-19178	21	10	belong	belong	VERB
ajst-19178	21	11	to	to	ADP
ajst-19178	21	12	cytotoxic	cytotoxic	ADJ
ajst-19178	21	13	drugs	drug	NOUN
ajst-19178	21	14	,	,	PUNCT
ajst-19178	21	15	also	also	ADV
ajst-19178	21	16	known	know	VERB
ajst-19178	21	17	as	as	ADP
ajst-19178	21	18	biological	biological	ADJ
ajst-19178	21	19	alkylating	alkylate	VERB
ajst-19178	21	20	agents	agent	NOUN
ajst-19178	21	21	,	,	PUNCT
ajst-19178	21	22	which	which	PRON
ajst-19178	21	23	can	can	AUX
ajst-19178	21	24	form	form	VERB
ajst-19178	21	25	carbocation	carbocation	NOUN
ajst-19178	21	26	ions	ion	NOUN
ajst-19178	21	27	or	or	CCONJ
ajst-19178	21	28	other	other	ADJ
ajst-19178	21	29	compounds	compound	NOUN
ajst-19178	21	30	with	with	ADP
ajst-19178	21	31	active	active	ADJ
ajst-19178	21	32	electrophilic	electrophilic	ADJ
ajst-19178	21	33	groups	group	NOUN
ajst-19178	21	34	in	in	ADP
ajst-19178	21	35	the	the	DET
ajst-19178	21	36	body	body	NOUN
ajst-19178	21	37	,	,	PUNCT
ajst-19178	21	38	and	and	CCONJ
ajst-19178	21	39	then	then	ADV
ajst-19178	21	40	covalently	covalently	ADV
ajst-19178	21	41	bind	bind	VERB
ajst-19178	21	42	with	with	ADP
ajst-19178	21	43	electron	electron	NOUN
ajst-19178	21	44	rich	rich	ADJ
ajst-19178	21	45	groups	group	NOUN
ajst-19178	21	46	(	(	PUNCT
ajst-19178	21	47	such	such	ADJ
ajst-19178	21	48	as	as	ADP
ajst-19178	21	49	amino	amino	NOUN
ajst-19178	21	50	,	,	PUNCT
ajst-19178	21	51	sulfhydryl	sulfhydryl	NOUN
ajst-19178	21	52	,	,	PUNCT
ajst-19178	21	53	hydroxyl	hydroxyl	NOUN
ajst-19178	21	54	,	,	PUNCT
ajst-19178	21	55	carboxyl	carboxyl	NOUN
ajst-19178	21	56	,	,	PUNCT
ajst-19178	21	57	phosphoric	phosphoric	NOUN
ajst-19178	21	58	acid	acid	NOUN
ajst-19178	21	59	,	,	PUNCT
ajst-19178	21	60	etc	etc	X
ajst-19178	21	61	.	.	X
ajst-19178	21	62	)	)	PUNCT
ajst-19178	21	63	in	in	ADP
ajst-19178	21	64	biological	biological	ADJ
ajst-19178	21	65	macromolecules	macromolecule	NOUN
ajst-19178	21	66	in	in	ADP
ajst-19178	21	67	cells	cell	NOUN
ajst-19178	21	68	.	.	PUNCT
ajst-19178	22	1	make	make	VERB
ajst-19178	22	2	it	it	PRON
ajst-19178	22	3	inactive	inactive	ADJ
ajst-19178	22	4	or	or	CCONJ
ajst-19178	22	5	make	make	VERB
ajst-19178	22	6	the	the	DET
ajst-19178	22	7	dna	dna	PROPN
ajst-19178	22	8	molecules	molecule	NOUN
ajst-19178	22	9	break	break	VERB
ajst-19178	22	10	,	,	PUNCT
ajst-19178	22	11	resulting	result	VERB
ajst-19178	22	12	in	in	ADP
ajst-19178	22	13	the	the	DET
ajst-19178	22	14	death	death	NOUN
ajst-19178	22	15	of	of	ADP
ajst-19178	22	16	tumor	tumor	NOUN
ajst-19178	22	17	cells	cell	NOUN
ajst-19178	22	18	.	.	PUNCT
ajst-19178	23	1	alkylating	alkylate	VERB
ajst-19178	23	2	agents	agent	NOUN
ajst-19178	23	3	are	be	AUX
ajst-19178	23	4	representative	representative	ADJ
ajst-19178	23	5	drugs	drug	NOUN
ajst-19178	23	6	such	such	ADJ
ajst-19178	23	7	as	as	ADP
ajst-19178	23	8	camustine	camustine	NOUN
ajst-19178	23	9	,	,	PUNCT
ajst-19178	23	10	nitrogen	nitrogen	NOUN
ajst-19178	23	11	mustard	mustard	NOUN
ajst-19178	23	12	hydrochloride	hydrochloride	NOUN
ajst-19178	23	13	,	,	PUNCT
ajst-19178	23	14	cyclophosphamide	cyclophosphamide	NOUN
ajst-19178	23	15	and	and	CCONJ
ajst-19178	23	16	milfarran	milfarran	PROPN
ajst-19178	23	17	,	,	PUNCT
ajst-19178	23	18	which	which	PRON
ajst-19178	23	19	have	have	AUX
ajst-19178	23	20	become	become	VERB
ajst-19178	23	21	important	important	ADJ
ajst-19178	23	22	drugs	drug	NOUN
ajst-19178	23	23	for	for	ADP
ajst-19178	23	24	cancer	cancer	NOUN
ajst-19178	23	25	chemotherapy	chemotherapy	NOUN
ajst-19178	23	26	.	.	PUNCT
ajst-19178	24	1	alkylating	alkylate	VERB
ajst-19178	24	2	agents	agent	NOUN
ajst-19178	24	3	are	be	AUX
ajst-19178	24	4	easy	easy	ADJ
ajst-19178	24	5	to	to	PART
ajst-19178	24	6	synthesize	synthesize	VERB
ajst-19178	24	7	and	and	CCONJ
ajst-19178	24	8	have	have	VERB
ajst-19178	24	9	important	important	ADJ
ajst-19178	24	10	value	value	NOUN
ajst-19178	24	11	in	in	ADP
ajst-19178	24	12	tumor	tumor	NOUN
ajst-19178	24	13	treatment	treatment	NOUN
ajst-19178	24	14	,	,	PUNCT
ajst-19178	24	15	but	but	CCONJ
ajst-19178	24	16	their	their	PRON
ajst-19178	24	17	selectivity	selectivity	NOUN
ajst-19178	24	18	is	be	AUX
ajst-19178	24	19	poor	poor	ADJ
ajst-19178	24	20	,	,	PUNCT
ajst-19178	24	21	adverse	adverse	ADJ
ajst-19178	24	22	reactions	reaction	NOUN
ajst-19178	24	23	are	be	AUX
ajst-19178	24	24	large	large	ADJ
ajst-19178	24	25	,	,	PUNCT
ajst-19178	24	26	and	and	CCONJ
ajst-19178	24	27	drug	drug	NOUN
ajst-19178	24	28	resistance	resistance	NOUN
ajst-19178	24	29	is	be	AUX
ajst-19178	24	30	easy	easy	ADJ
ajst-19178	24	31	to	to	PART
ajst-19178	24	32	occur	occur	VERB
ajst-19178	24	33	.	.	PUNCT
ajst-19178	25	1	the	the	DET
ajst-19178	25	2	alkylating	alkylate	VERB
ajst-19178	25	3	agent	agent	NOUN
ajst-19178	25	4	,	,	PUNCT
ajst-19178	25	5	temozolomide	temozolomide	NOUN
ajst-19178	25	6	,	,	PUNCT
ajst-19178	25	7	combined	combine	VERB
ajst-19178	25	8	with	with	ADP
ajst-19178	25	9	artesunate	artesunate	NOUN
ajst-19178	25	10	and	and	CCONJ
ajst-19178	25	11	phosphatidylcholine	phosphatidylcholine	NOUN
ajst-19178	25	12	to	to	PART
ajst-19178	25	13	form	form	VERB
ajst-19178	25	14	targeted	target	VERB
ajst-19178	25	15	liposomes	liposome	NOUN
ajst-19178	25	16	,	,	PUNCT
ajst-19178	25	17	reduces	reduce	VERB
ajst-19178	25	18	the	the	DET
ajst-19178	25	19	effective	effective	ADJ
ajst-19178	25	20	dose	dose	NOUN
ajst-19178	25	21	and	and	CCONJ
ajst-19178	25	22	toxic	toxic	ADJ
ajst-19178	25	23	effects	effect	NOUN
ajst-19178	25	24	of	of	ADP
ajst-19178	25	25	temozolomide	temozolomide	NOUN
ajst-19178	25	26	,	,	PUNCT
ajst-19178	25	27	and	and	CCONJ
ajst-19178	25	28	provides	provide	VERB
ajst-19178	25	29	a	a	DET
ajst-19178	25	30	new	new	ADJ
ajst-19178	25	31	therapeutic	therapeutic	ADJ
ajst-19178	25	32	method	method	NOUN
ajst-19178	25	33	for	for	ADP
ajst-19178	25	34	the	the	DET
ajst-19178	25	35	clinical	clinical	ADJ
ajst-19178	25	36	treatment	treatment	NOUN
ajst-19178	25	37	of	of	ADP
ajst-19178	25	38	drug	drug	NOUN
ajst-19178	25	39	-	-	PUNCT
ajst-19178	25	40	resistant	resistant	ADJ
ajst-19178	25	41	glioblastoma	glioblastoma	NOUN
ajst-19178	25	42	[	[	X
ajst-19178	25	43	15	15	NUM
ajst-19178	25	44	]	]	PUNCT
ajst-19178	25	45	.	.	PUNCT
ajst-19178	26	1	2.2	2.2	NUM
ajst-19178	26	2	.	.	PUNCT
ajst-19178	26	3	anti	anti	ADJ
ajst-19178	26	4	-	-	ADJ
ajst-19178	26	5	tumor	tumor	ADJ
ajst-19178	26	6	antibiotics	antibiotic	NOUN
ajst-19178	26	7	anti	anti	ADJ
ajst-19178	26	8	-	-	ADJ
ajst-19178	26	9	tumor	tumor	ADJ
ajst-19178	26	10	antibiotics	antibiotic	NOUN
ajst-19178	26	11	[	[	X
ajst-19178	26	12	16	16	NUM
ajst-19178	26	13	]	]	PUNCT
ajst-19178	26	14	are	be	AUX
ajst-19178	26	15	chemicals	chemical	NOUN
ajst-19178	26	16	produced	produce	VERB
ajst-19178	26	17	by	by	ADP
ajst-19178	26	18	microorganisms	microorganism	NOUN
ajst-19178	26	19	with	with	ADP
ajst-19178	26	20	anti	anti	ADJ
ajst-19178	26	21	-	-	ADJ
ajst-19178	26	22	tumor	tumor	ADJ
ajst-19178	26	23	activity	activity	NOUN
ajst-19178	26	24	and	and	CCONJ
ajst-19178	26	25	are	be	AUX
ajst-19178	26	26	an	an	DET
ajst-19178	26	27	important	important	ADJ
ajst-19178	26	28	category	category	NOUN
ajst-19178	26	29	of	of	ADP
ajst-19178	26	30	chemotherapy	chemotherapy	NOUN
ajst-19178	26	31	drugs	drug	NOUN
ajst-19178	26	32	for	for	ADP
ajst-19178	26	33	malignant	malignant	ADJ
ajst-19178	26	34	tumors	tumor	NOUN
ajst-19178	26	35	.	.	PUNCT
ajst-19178	27	1	according	accord	VERB
ajst-19178	27	2	to	to	ADP
ajst-19178	27	3	their	their	PRON
ajst-19178	27	4	structure	structure	NOUN
ajst-19178	27	5	,	,	PUNCT
ajst-19178	27	6	antitumor	antitumor	PROPN
ajst-19178	27	7	antibiotics	antibiotic	NOUN
ajst-19178	27	8	can	can	AUX
ajst-19178	27	9	be	be	AUX
ajst-19178	27	10	divided	divide	VERB
ajst-19178	27	11	into	into	ADP
ajst-19178	27	12	anthracycline	anthracycline	PROPN
ajst-19178	27	13	,	,	PUNCT
ajst-19178	27	14	enediyne	enediyne	PROPN
ajst-19178	27	15	,	,	PUNCT
ajst-19178	27	16	macrolides	macrolide	NOUN
ajst-19178	27	17	,	,	PUNCT
ajst-19178	27	18	glycopeptides	glycopeptide	NOUN
ajst-19178	27	19	and	and	CCONJ
ajst-19178	27	20	benzodipyrrole	benzodipyrrole	NOUN
ajst-19178	27	21	,	,	PUNCT
ajst-19178	27	22	represented	represent	VERB
ajst-19178	27	23	by	by	ADP
ajst-19178	27	24	mitomycin	mitomycin	PROPN
ajst-19178	27	25	,	,	PUNCT
ajst-19178	27	26	epirubicin	epirubicin	PRON
ajst-19178	27	27	,	,	PUNCT
ajst-19178	27	28	doxorubicin	doxorubicin	PROPN
ajst-19178	27	29	,	,	PUNCT
ajst-19178	27	30	bleomycin	bleomycin	PROPN
ajst-19178	27	31	and	and	CCONJ
ajst-19178	27	32	doxorubicin	doxorubicin	PROPN
ajst-19178	27	33	magnitude	magnitude	NOUN
ajst-19178	27	34	.	.	PUNCT
ajst-19178	28	1	this	this	DET
ajst-19178	28	2	class	class	NOUN
ajst-19178	28	3	of	of	ADP
ajst-19178	28	4	drugs	drug	NOUN
ajst-19178	28	5	can	can	AUX
ajst-19178	28	6	play	play	VERB
ajst-19178	28	7	an	an	DET
ajst-19178	28	8	anticancer	anticancer	NOUN
ajst-19178	28	9	role	role	NOUN
ajst-19178	28	10	by	by	ADP
ajst-19178	28	11	interfering	interfere	VERB
ajst-19178	28	12	with	with	ADP
ajst-19178	28	13	nucleic	nucleic	ADJ
ajst-19178	28	14	acid	acid	NOUN
ajst-19178	28	15	and	and	CCONJ
ajst-19178	28	16	protein	protein	NOUN
ajst-19178	28	17	synthesis	synthesis	NOUN
ajst-19178	28	18	,	,	PUNCT
ajst-19178	28	19	but	but	CCONJ
ajst-19178	28	20	their	their	PRON
ajst-19178	28	21	clinical	clinical	ADJ
ajst-19178	28	22	use	use	NOUN
ajst-19178	28	23	is	be	AUX
ajst-19178	28	24	limited	limit	VERB
ajst-19178	28	25	because	because	SCONJ
ajst-19178	28	26	of	of	ADP
ajst-19178	28	27	their	their	PRON
ajst-19178	28	28	powerful	powerful	ADJ
ajst-19178	28	29	side	side	NOUN
ajst-19178	28	30	effects	effect	NOUN
ajst-19178	28	31	,	,	PUNCT
ajst-19178	28	32	such	such	ADJ
ajst-19178	28	33	as	as	ADP
ajst-19178	28	34	anthracyclines	anthracycline	NOUN
ajst-19178	28	35	,	,	PUNCT
ajst-19178	28	36	which	which	PRON
ajst-19178	28	37	can	can	AUX
ajst-19178	28	38	cause	cause	VERB
ajst-19178	28	39	cardiac	cardiac	ADJ
ajst-19178	28	40	side	side	NOUN
ajst-19178	28	41	effects	effect	NOUN
ajst-19178	28	42	[	[	X
ajst-19178	28	43	17	17	NUM
ajst-19178	28	44	]	]	PUNCT
ajst-19178	28	45	.	.	PUNCT
ajst-19178	29	1	at	at	ADP
ajst-19178	29	2	present	present	ADJ
ajst-19178	29	3	,	,	PUNCT
ajst-19178	29	4	most	most	ADJ
ajst-19178	29	5	anti	anti	ADJ
ajst-19178	29	6	-	-	ADJ
ajst-19178	29	7	tumor	tumor	ADJ
ajst-19178	29	8	antibiotic	antibiotic	ADJ
ajst-19178	29	9	drugs	drug	NOUN
ajst-19178	29	10	are	be	AUX
ajst-19178	29	11	in	in	ADP
ajst-19178	29	12	a	a	DET
ajst-19178	29	13	198	198	NUM
ajst-19178	29	14	period	period	NOUN
ajst-19178	29	15	of	of	ADP
ajst-19178	29	16	rapid	rapid	ADJ
ajst-19178	29	17	development	development	NOUN
ajst-19178	29	18	,	,	PUNCT
ajst-19178	29	19	which	which	PRON
ajst-19178	29	20	can	can	AUX
ajst-19178	29	21	reduce	reduce	VERB
ajst-19178	29	22	their	their	PRON
ajst-19178	29	23	resistance	resistance	NOUN
ajst-19178	29	24	and	and	CCONJ
ajst-19178	29	25	reduce	reduce	VERB
ajst-19178	29	26	adverse	adverse	ADJ
ajst-19178	29	27	reactions	reaction	NOUN
ajst-19178	29	28	by	by	ADP
ajst-19178	29	29	combining	combine	VERB
ajst-19178	29	30	with	with	ADP
ajst-19178	29	31	other	other	ADJ
ajst-19178	29	32	drugs	drug	NOUN
ajst-19178	29	33	,	,	PUNCT
ajst-19178	29	34	and	and	CCONJ
ajst-19178	29	35	improve	improve	VERB
ajst-19178	29	36	the	the	DET
ajst-19178	29	37	quality	quality	NOUN
ajst-19178	29	38	of	of	ADP
ajst-19178	29	39	life	life	NOUN
ajst-19178	29	40	of	of	ADP
ajst-19178	29	41	patients	patient	NOUN
ajst-19178	29	42	.	.	PUNCT
ajst-19178	30	1	studies	study	NOUN
ajst-19178	30	2	[	[	X
ajst-19178	30	3	18	18	NUM
ajst-19178	30	4	]	]	PUNCT
ajst-19178	30	5	have	have	AUX
ajst-19178	30	6	shown	show	VERB
ajst-19178	30	7	that	that	SCONJ
ajst-19178	30	8	art	art	NOUN
ajst-19178	30	9	and	and	CCONJ
ajst-19178	30	10	doxorubicin	doxorubicin	PROPN
ajst-19178	30	11	have	have	VERB
ajst-19178	30	12	a	a	DET
ajst-19178	30	13	synergistic	synergistic	ADJ
ajst-19178	30	14	effect	effect	NOUN
ajst-19178	30	15	,	,	PUNCT
ajst-19178	30	16	which	which	PRON
ajst-19178	30	17	can	can	AUX
ajst-19178	30	18	enhance	enhance	VERB
ajst-19178	30	19	the	the	DET
ajst-19178	30	20	apoptotic	apoptotic	ADJ
ajst-19178	30	21	cell	cell	NOUN
ajst-19178	30	22	death	death	NOUN
ajst-19178	30	23	of	of	ADP
ajst-19178	30	24	leukemia	leukemia	NOUN
ajst-19178	30	25	t	t	NOUN
ajst-19178	30	26	cells	cell	NOUN
ajst-19178	30	27	.	.	PUNCT
ajst-19178	31	1	doxorubicin	doxorubicin	PROPN
ajst-19178	31	2	combined	combine	VERB
ajst-19178	31	3	with	with	ADP
ajst-19178	31	4	art	art	NOUN
ajst-19178	31	5	can	can	AUX
ajst-19178	31	6	reduce	reduce	VERB
ajst-19178	31	7	the	the	DET
ajst-19178	31	8	toxicity	toxicity	NOUN
ajst-19178	31	9	of	of	ADP
ajst-19178	31	10	each	each	DET
ajst-19178	31	11	drug	drug	NOUN
ajst-19178	31	12	and	and	CCONJ
ajst-19178	31	13	has	have	VERB
ajst-19178	31	14	a	a	DET
ajst-19178	31	15	significant	significant	ADJ
ajst-19178	31	16	therapeutic	therapeutic	ADJ
ajst-19178	31	17	effect	effect	NOUN
ajst-19178	31	18	on	on	ADP
ajst-19178	31	19	breast	breast	NOUN
ajst-19178	31	20	and	and	CCONJ
ajst-19178	31	21	colon	colon	NOUN
ajst-19178	31	22	cancer	cancer	NOUN
ajst-19178	31	23	[	[	X
ajst-19178	31	24	19	19	NUM
ajst-19178	31	25	]	]	PUNCT
ajst-19178	31	26	.	.	PUNCT
ajst-19178	32	1	2.3	2.3	NUM
ajst-19178	32	2	.	.	PUNCT
ajst-19178	33	1	platinum	platinum	NOUN
ajst-19178	33	2	metals	metal	NOUN
ajst-19178	33	3	platinum	platinum	NOUN
ajst-19178	33	4	-	-	PUNCT
ajst-19178	33	5	based	base	VERB
ajst-19178	33	6	anti	anti	ADJ
ajst-19178	33	7	-	-	ADJ
ajst-19178	33	8	tumor	tumor	ADJ
ajst-19178	33	9	drugs	drug	NOUN
ajst-19178	33	10	[	[	PUNCT
ajst-19178	33	11	20	20	NUM
ajst-19178	33	12	-	-	SYM
ajst-19178	33	13	21	21	NUM
ajst-19178	33	14	]	]	PUNCT
ajst-19178	33	15	have	have	AUX
ajst-19178	33	16	been	be	AUX
ajst-19178	33	17	widely	widely	ADV
ajst-19178	33	18	used	use	VERB
ajst-19178	33	19	in	in	ADP
ajst-19178	33	20	the	the	DET
ajst-19178	33	21	single	single	ADJ
ajst-19178	33	22	or	or	CCONJ
ajst-19178	33	23	combined	combined	ADJ
ajst-19178	33	24	treatment	treatment	NOUN
ajst-19178	33	25	of	of	ADP
ajst-19178	33	26	a	a	DET
ajst-19178	33	27	variety	variety	NOUN
ajst-19178	33	28	of	of	ADP
ajst-19178	33	29	clinical	clinical	ADJ
ajst-19178	33	30	tumors	tumor	NOUN
ajst-19178	33	31	,	,	PUNCT
ajst-19178	33	32	and	and	CCONJ
ajst-19178	33	33	are	be	AUX
ajst-19178	33	34	currently	currently	ADV
ajst-19178	33	35	the	the	DET
ajst-19178	33	36	most	most	ADV
ajst-19178	33	37	widely	widely	ADV
ajst-19178	33	38	used	use	VERB
ajst-19178	33	39	antitumor	antitumor	PROPN
ajst-19178	33	40	drugs	drug	NOUN
ajst-19178	33	41	in	in	ADP
ajst-19178	33	42	clinical	clinical	ADJ
ajst-19178	33	43	practice	practice	NOUN
ajst-19178	33	44	.	.	PUNCT
ajst-19178	34	1	the	the	DET
ajst-19178	34	2	main	main	ADJ
ajst-19178	34	3	representative	representative	ADJ
ajst-19178	34	4	drugs	drug	NOUN
ajst-19178	34	5	include	include	VERB
ajst-19178	34	6	cisplatin	cisplatin	NOUN
ajst-19178	34	7	,	,	PUNCT
ajst-19178	34	8	carboplatin	carboplatin	NOUN
ajst-19178	34	9	,	,	PUNCT
ajst-19178	34	10	oxaliplatin	oxaliplatin	ADJ
ajst-19178	34	11	and	and	CCONJ
ajst-19178	34	12	other	other	ADJ
ajst-19178	34	13	bivalent	bivalent	ADJ
ajst-19178	34	14	platinum	platinum	NOUN
ajst-19178	34	15	.	.	PUNCT
ajst-19178	35	1	after	after	ADP
ajst-19178	35	2	entering	enter	VERB
ajst-19178	35	3	the	the	DET
ajst-19178	35	4	nucleus	nucleus	NOUN
ajst-19178	35	5	,	,	PUNCT
ajst-19178	35	6	bivalent	bivalent	ADJ
ajst-19178	35	7	platinum	platinum	NOUN
ajst-19178	35	8	drugs	drug	NOUN
ajst-19178	35	9	can	can	AUX
ajst-19178	35	10	form	form	VERB
ajst-19178	35	11	adduct	adduct	VERB
ajst-19178	35	12	with	with	ADP
ajst-19178	35	13	dna	dna	PROPN
ajst-19178	35	14	,	,	PUNCT
ajst-19178	35	15	inhibit	inhibit	VERB
ajst-19178	35	16	dna	dna	NOUN
ajst-19178	35	17	replication	replication	NOUN
ajst-19178	35	18	and	and	CCONJ
ajst-19178	35	19	transcription	transcription	NOUN
ajst-19178	35	20	,	,	PUNCT
ajst-19178	35	21	induce	induce	VERB
ajst-19178	35	22	dna	dna	ADJ
ajst-19178	35	23	damage	damage	NOUN
ajst-19178	35	24	,	,	PUNCT
ajst-19178	35	25	activate	activate	VERB
ajst-19178	35	26	atr	atr	NOUN
ajst-19178	35	27	pathway	pathway	NOUN
ajst-19178	35	28	and	and	CCONJ
ajst-19178	35	29	trigger	trigger	NOUN
ajst-19178	35	30	cycle	cycle	NOUN
ajst-19178	35	31	arrest	arrest	NOUN
ajst-19178	35	32	regulated	regulate	VERB
ajst-19178	35	33	by	by	ADP
ajst-19178	35	34	p53	p53	NOUN
ajst-19178	35	35	and	and	CCONJ
ajst-19178	35	36	apoptosis	apoptosis	NOUN
ajst-19178	35	37	factors	factor	NOUN
ajst-19178	35	38	,	,	PUNCT
ajst-19178	35	39	thus	thus	ADV
ajst-19178	35	40	inducing	induce	VERB
ajst-19178	35	41	mitochondrial	mitochondrial	ADJ
ajst-19178	35	42	regulated	regulate	VERB
ajst-19178	35	43	caspase	caspase	NOUN
ajst-19178	35	44	-	-	PUNCT
ajst-19178	35	45	dependent	dependent	ADJ
ajst-19178	35	46	and	and	CCONJ
ajst-19178	35	47	non	non	ADJ
ajst-19178	35	48	-	-	ADJ
ajst-19178	35	49	dependent	dependent	ADJ
ajst-19178	35	50	apoptosis	apoptosis	NOUN
ajst-19178	35	51	pathways	pathway	NOUN
ajst-19178	35	52	,	,	PUNCT
ajst-19178	35	53	inducing	induce	VERB
ajst-19178	35	54	tumor	tumor	NOUN
ajst-19178	35	55	cell	cell	NOUN
ajst-19178	35	56	apoptosis	apoptosis	NOUN
ajst-19178	35	57	and	and	CCONJ
ajst-19178	35	58	exerting	exert	VERB
ajst-19178	35	59	anti	anti	ADJ
ajst-19178	35	60	-	-	ADJ
ajst-19178	35	61	tumor	tumor	ADJ
ajst-19178	35	62	effects	effect	NOUN
ajst-19178	35	63	[	[	X
ajst-19178	35	64	22	22	NUM
ajst-19178	35	65	]	]	PUNCT
ajst-19178	35	66	.	.	PUNCT
ajst-19178	36	1	however	however	ADV
ajst-19178	36	2	,	,	PUNCT
ajst-19178	36	3	bivalent	bivalent	ADJ
ajst-19178	36	4	platinum	platinum	NOUN
ajst-19178	36	5	drugs	drug	NOUN
ajst-19178	36	6	have	have	VERB
ajst-19178	36	7	serious	serious	ADJ
ajst-19178	36	8	side	side	NOUN
ajst-19178	36	9	effects	effect	NOUN
ajst-19178	36	10	such	such	ADJ
ajst-19178	36	11	as	as	ADP
ajst-19178	36	12	ototoxicity	ototoxicity	NOUN
ajst-19178	36	13	,	,	PUNCT
ajst-19178	36	14	nephrotoxicity	nephrotoxicity	NOUN
ajst-19178	36	15	and	and	CCONJ
ajst-19178	36	16	cardiotoxicity	cardiotoxicity	NOUN
ajst-19178	36	17	during	during	ADP
ajst-19178	36	18	treatment	treatment	NOUN
ajst-19178	36	19	,	,	PUNCT
ajst-19178	36	20	which	which	PRON
ajst-19178	36	21	are	be	AUX
ajst-19178	36	22	dose	dose	VERB
ajst-19178	36	23	-	-	PUNCT
ajst-19178	36	24	dependent	dependent	ADJ
ajst-19178	36	25	[	[	X
ajst-19178	36	26	23	23	NUM
ajst-19178	36	27	]	]	PUNCT
ajst-19178	36	28	.	.	PUNCT
ajst-19178	37	1	at	at	ADP
ajst-19178	37	2	present	present	ADJ
ajst-19178	37	3	,	,	PUNCT
ajst-19178	37	4	platinum	platinum	NOUN
ajst-19178	37	5	drugs	drug	NOUN
ajst-19178	37	6	are	be	AUX
ajst-19178	37	7	mainly	mainly	ADV
ajst-19178	37	8	used	use	VERB
ajst-19178	37	9	in	in	ADP
ajst-19178	37	10	combination	combination	NOUN
ajst-19178	37	11	with	with	ADP
ajst-19178	37	12	other	other	ADJ
ajst-19178	37	13	anti	anti	ADJ
ajst-19178	37	14	-	-	ADJ
ajst-19178	37	15	tumor	tumor	ADJ
ajst-19178	37	16	drugs	drug	NOUN
ajst-19178	37	17	to	to	PART
ajst-19178	37	18	reduce	reduce	VERB
ajst-19178	37	19	the	the	DET
ajst-19178	37	20	side	side	NOUN
ajst-19178	37	21	effects	effect	NOUN
ajst-19178	37	22	and	and	CCONJ
ajst-19178	37	23	drug	drug	NOUN
ajst-19178	37	24	resistance	resistance	NOUN
ajst-19178	37	25	,	,	PUNCT
ajst-19178	37	26	and	and	CCONJ
ajst-19178	37	27	improve	improve	VERB
ajst-19178	37	28	the	the	DET
ajst-19178	37	29	anti	anti	ADJ
ajst-19178	37	30	-	-	ADJ
ajst-19178	37	31	tumor	tumor	ADJ
ajst-19178	37	32	effect	effect	NOUN
ajst-19178	37	33	of	of	ADP
ajst-19178	37	34	this	this	DET
ajst-19178	37	35	drug	drug	NOUN
ajst-19178	37	36	.	.	PUNCT
ajst-19178	38	1	the	the	DET
ajst-19178	38	2	combination	combination	NOUN
ajst-19178	38	3	of	of	ADP
ajst-19178	38	4	art	art	NOUN
ajst-19178	38	5	and	and	CCONJ
ajst-19178	38	6	platinum	platinum	NOUN
ajst-19178	38	7	drugs	drug	NOUN
ajst-19178	38	8	can	can	AUX
ajst-19178	38	9	effectively	effectively	ADV
ajst-19178	38	10	induce	induce	VERB
ajst-19178	38	11	autophagy	autophagy	ADJ
ajst-19178	38	12	death	death	NOUN
ajst-19178	38	13	and	and	CCONJ
ajst-19178	38	14	apoptosis	apoptosis	NOUN
ajst-19178	38	15	,	,	PUNCT
ajst-19178	38	16	block	block	VERB
ajst-19178	38	17	the	the	DET
ajst-19178	38	18	cell	cell	NOUN
ajst-19178	38	19	cycle	cycle	NOUN
ajst-19178	38	20	,	,	PUNCT
ajst-19178	38	21	have	have	VERB
ajst-19178	38	22	significant	significant	ADJ
ajst-19178	38	23	anti	anti	ADJ
ajst-19178	38	24	-	-	ADJ
ajst-19178	38	25	tumor	tumor	ADJ
ajst-19178	38	26	effect	effect	NOUN
ajst-19178	38	27	in	in	ADP
ajst-19178	38	28	vivo	vivo	NOUN
ajst-19178	38	29	,	,	PUNCT
ajst-19178	38	30	and	and	CCONJ
ajst-19178	38	31	greatly	greatly	ADV
ajst-19178	38	32	improve	improve	VERB
ajst-19178	38	33	the	the	DET
ajst-19178	38	34	safety	safety	NOUN
ajst-19178	38	35	of	of	ADP
ajst-19178	38	36	drugs	drug	NOUN
ajst-19178	38	37	,	,	PUNCT
ajst-19178	38	38	especially	especially	ADV
ajst-19178	38	39	reduce	reduce	VERB
ajst-19178	38	40	the	the	DET
ajst-19178	38	41	renal	renal	ADJ
ajst-19178	38	42	toxicity	toxicity	NOUN
ajst-19178	38	43	of	of	ADP
ajst-19178	38	44	platinum	platinum	NOUN
ajst-19178	38	45	drugs	drug	NOUN
ajst-19178	38	46	[	[	X
ajst-19178	38	47	24	24	NUM
ajst-19178	38	48	]	]	PUNCT
ajst-19178	38	49	.	.	PUNCT
ajst-19178	39	1	the	the	DET
ajst-19178	39	2	combination	combination	NOUN
ajst-19178	39	3	of	of	ADP
ajst-19178	39	4	art	art	NOUN
ajst-19178	39	5	and	and	CCONJ
ajst-19178	39	6	cisplatin	cisplatin	NOUN
ajst-19178	39	7	has	have	VERB
ajst-19178	39	8	a	a	DET
ajst-19178	39	9	synergistic	synergistic	ADJ
ajst-19178	39	10	effect	effect	NOUN
ajst-19178	39	11	,	,	PUNCT
ajst-19178	39	12	which	which	PRON
ajst-19178	39	13	can	can	AUX
ajst-19178	39	14	significantly	significantly	ADV
ajst-19178	39	15	improve	improve	VERB
ajst-19178	39	16	the	the	DET
ajst-19178	39	17	anti	anti	ADJ
ajst-19178	39	18	-	-	ADJ
ajst-19178	39	19	lung	lung	ADJ
ajst-19178	39	20	cancer	cancer	NOUN
ajst-19178	39	21	efficacy	efficacy	NOUN
ajst-19178	39	22	of	of	ADP
ajst-19178	39	23	art	art	NOUN
ajst-19178	39	24	used	use	VERB
ajst-19178	39	25	alone	alone	ADV
ajst-19178	39	26	[	[	X
ajst-19178	39	27	25	25	NUM
ajst-19178	39	28	]	]	PUNCT
ajst-19178	39	29	.	.	PUNCT
ajst-19178	40	1	at	at	ADP
ajst-19178	40	2	the	the	DET
ajst-19178	40	3	same	same	ADJ
ajst-19178	40	4	time	time	NOUN
ajst-19178	40	5	,	,	PUNCT
ajst-19178	40	6	the	the	DET
ajst-19178	40	7	combination	combination	NOUN
ajst-19178	40	8	of	of	ADP
ajst-19178	40	9	art	art	NOUN
ajst-19178	40	10	and	and	CCONJ
ajst-19178	40	11	carboplatin	carboplatin	NOUN
ajst-19178	40	12	also	also	ADV
ajst-19178	40	13	has	have	VERB
ajst-19178	40	14	a	a	DET
ajst-19178	40	15	synergistic	synergistic	ADJ
ajst-19178	40	16	effect	effect	NOUN
ajst-19178	40	17	,	,	PUNCT
ajst-19178	40	18	which	which	PRON
ajst-19178	40	19	can	can	AUX
ajst-19178	40	20	play	play	VERB
ajst-19178	40	21	an	an	DET
ajst-19178	40	22	anticancer	anticancer	NOUN
ajst-19178	40	23	role	role	NOUN
ajst-19178	40	24	by	by	ADP
ajst-19178	40	25	enhancing	enhance	VERB
ajst-19178	40	26	apoptosis	apoptosis	NOUN
ajst-19178	40	27	[	[	X
ajst-19178	40	28	26	26	NUM
ajst-19178	40	29	]	]	PUNCT
ajst-19178	40	30	.	.	PUNCT
ajst-19178	41	1	2.4	2.4	NUM
ajst-19178	41	2	.	.	PUNCT
ajst-19178	42	1	anti	anti	ADJ
ajst-19178	42	2	-	-	ADJ
ajst-19178	42	3	metabolism	metabolism	ADJ
ajst-19178	42	4	anti	anti	ADJ
ajst-19178	42	5	-	-	ADJ
ajst-19178	42	6	metabolic	metabolic	ADJ
ajst-19178	42	7	drugs	drug	NOUN
ajst-19178	42	8	[	[	X
ajst-19178	42	9	27	27	NUM
ajst-19178	42	10	]	]	PUNCT
ajst-19178	42	11	are	be	AUX
ajst-19178	42	12	a	a	DET
ajst-19178	42	13	class	class	NOUN
ajst-19178	42	14	of	of	ADP
ajst-19178	42	15	anti	anti	ADJ
ajst-19178	42	16	-	-	ADJ
ajst-19178	42	17	tumor	tumor	ADJ
ajst-19178	42	18	drugs	drug	NOUN
ajst-19178	42	19	that	that	PRON
ajst-19178	42	20	work	work	VERB
ajst-19178	42	21	by	by	ADP
ajst-19178	42	22	interfering	interfere	VERB
ajst-19178	42	23	with	with	ADP
ajst-19178	42	24	essential	essential	ADJ
ajst-19178	42	25	biochemical	biochemical	ADJ
ajst-19178	42	26	processes	process	NOUN
ajst-19178	42	27	.	.	PUNCT
ajst-19178	43	1	most	most	ADJ
ajst-19178	43	2	of	of	ADP
ajst-19178	43	3	these	these	DET
ajst-19178	43	4	drugs	drug	NOUN
ajst-19178	43	5	are	be	AUX
ajst-19178	43	6	nucleoside	nucleoside	ADJ
ajst-19178	43	7	analogues	analogue	NOUN
ajst-19178	43	8	,	,	PUNCT
ajst-19178	43	9	which	which	PRON
ajst-19178	43	10	can	can	AUX
ajst-19178	43	11	specifically	specifically	ADV
ajst-19178	43	12	interfere	interfere	VERB
ajst-19178	43	13	with	with	ADP
ajst-19178	43	14	nucleic	nucleic	ADJ
ajst-19178	43	15	acid	acid	NOUN
ajst-19178	43	16	metabolism	metabolism	NOUN
ajst-19178	43	17	,	,	PUNCT
ajst-19178	43	18	inhibit	inhibit	VERB
ajst-19178	43	19	the	the	DET
ajst-19178	43	20	division	division	NOUN
ajst-19178	43	21	and	and	CCONJ
ajst-19178	43	22	proliferation	proliferation	NOUN
ajst-19178	43	23	of	of	ADP
ajst-19178	43	24	tumor	tumor	NOUN
ajst-19178	43	25	cells	cell	NOUN
ajst-19178	43	26	,	,	PUNCT
ajst-19178	43	27	and	and	CCONJ
ajst-19178	43	28	eventually	eventually	ADV
ajst-19178	43	29	lead	lead	VERB
ajst-19178	43	30	to	to	ADP
ajst-19178	43	31	the	the	DET
ajst-19178	43	32	death	death	NOUN
ajst-19178	43	33	of	of	ADP
ajst-19178	43	34	tumor	tumor	NOUN
ajst-19178	43	35	cells	cell	NOUN
ajst-19178	43	36	.	.	PUNCT
ajst-19178	44	1	including	include	VERB
ajst-19178	44	2	thymidylate	thymidylate	ADJ
ajst-19178	44	3	synthase	synthase	NOUN
ajst-19178	44	4	inhibitors	inhibitor	NOUN
ajst-19178	44	5	,	,	PUNCT
ajst-19178	44	6	dna	dna	NOUN
ajst-19178	44	7	polymerase	polymerase	NOUN
ajst-19178	44	8	inhibitors	inhibitor	NOUN
ajst-19178	44	9	,	,	PUNCT
ajst-19178	44	10	dihydrofolate	dihydrofolate	ADJ
ajst-19178	44	11	reductase	reductase	NOUN
ajst-19178	44	12	inhibitors	inhibitor	NOUN
ajst-19178	44	13	,	,	PUNCT
ajst-19178	44	14	purine	purine	NOUN
ajst-19178	44	15	nucleotide	nucleotide	ADJ
ajst-19178	44	16	synthesis	synthesis	NOUN
ajst-19178	44	17	inhibitors	inhibitor	NOUN
ajst-19178	44	18	and	and	CCONJ
ajst-19178	44	19	so	so	ADV
ajst-19178	44	20	on	on	ADV
ajst-19178	44	21	.	.	PUNCT
ajst-19178	45	1	common	common	ADJ
ajst-19178	45	2	anti	anti	ADJ
ajst-19178	45	3	-	-	ADJ
ajst-19178	45	4	metabolic	metabolic	ADJ
ajst-19178	45	5	representative	representative	ADJ
ajst-19178	45	6	drugs	drug	NOUN
ajst-19178	45	7	include	include	VERB
ajst-19178	45	8	5	5	NUM
ajst-19178	45	9	-	-	PUNCT
ajst-19178	45	10	fluorouracil	fluorouracil	NOUN
ajst-19178	45	11	,	,	PUNCT
ajst-19178	45	12	methotrexate	methotrexate	NOUN
ajst-19178	45	13	,	,	PUNCT
ajst-19178	45	14	cytarabine	cytarabine	NOUN
ajst-19178	45	15	,	,	PUNCT
ajst-19178	45	16	etc	etc	X
ajst-19178	45	17	.	.	X
ajst-19178	45	18	among	among	ADP
ajst-19178	45	19	them	they	PRON
ajst-19178	45	20	,	,	PUNCT
ajst-19178	45	21	5	5	NUM
ajst-19178	45	22	-	-	PUNCT
ajst-19178	45	23	fluorouracil	fluorouracil	NOUN
ajst-19178	45	24	is	be	AUX
ajst-19178	45	25	widely	widely	ADV
ajst-19178	45	26	used	use	VERB
ajst-19178	45	27	in	in	ADP
ajst-19178	45	28	the	the	DET
ajst-19178	45	29	treatment	treatment	NOUN
ajst-19178	45	30	of	of	ADP
ajst-19178	45	31	colon	colon	NOUN
ajst-19178	45	32	cancer	cancer	NOUN
ajst-19178	45	33	and	and	CCONJ
ajst-19178	45	34	breast	breast	NOUN
ajst-19178	45	35	cancer	cancer	NOUN
ajst-19178	45	36	,	,	PUNCT
ajst-19178	45	37	but	but	CCONJ
ajst-19178	45	38	it	it	PRON
ajst-19178	45	39	has	have	VERB
ajst-19178	45	40	serious	serious	ADJ
ajst-19178	45	41	toxic	toxic	ADJ
ajst-19178	45	42	effects	effect	NOUN
ajst-19178	45	43	on	on	ADP
ajst-19178	45	44	the	the	DET
ajst-19178	45	45	heart	heart	NOUN
ajst-19178	45	46	,	,	PUNCT
ajst-19178	45	47	so	so	ADV
ajst-19178	45	48	combination	combination	NOUN
ajst-19178	45	49	therapy	therapy	NOUN
ajst-19178	45	50	is	be	AUX
ajst-19178	45	51	often	often	ADV
ajst-19178	45	52	used	use	VERB
ajst-19178	45	53	clinically	clinically	ADV
ajst-19178	45	54	to	to	PART
ajst-19178	45	55	reduce	reduce	VERB
ajst-19178	45	56	the	the	DET
ajst-19178	45	57	toxic	toxic	ADJ
ajst-19178	45	58	side	side	NOUN
ajst-19178	45	59	effects	effect	NOUN
ajst-19178	45	60	caused	cause	VERB
ajst-19178	45	61	by	by	ADP
ajst-19178	45	62	its	its	PRON
ajst-19178	45	63	single	single	ADJ
ajst-19178	45	64	use	use	NOUN
ajst-19178	45	65	[	[	X
ajst-19178	45	66	28	28	NUM
ajst-19178	45	67	]	]	PUNCT
ajst-19178	45	68	.	.	PUNCT
ajst-19178	46	1	the	the	DET
ajst-19178	46	2	combination	combination	NOUN
ajst-19178	46	3	of	of	ADP
ajst-19178	46	4	art	art	NOUN
ajst-19178	46	5	and	and	CCONJ
ajst-19178	46	6	5	5	NUM
ajst-19178	46	7	-	-	PUNCT
ajst-19178	46	8	fluorouracil	fluorouracil	NOUN
ajst-19178	46	9	can	can	AUX
ajst-19178	46	10	reduce	reduce	VERB
ajst-19178	46	11	the	the	DET
ajst-19178	46	12	adverse	adverse	ADJ
ajst-19178	46	13	reactions	reaction	NOUN
ajst-19178	46	14	caused	cause	VERB
ajst-19178	46	15	by	by	ADP
ajst-19178	46	16	5	5	NUM
ajst-19178	46	17	-	-	PUNCT
ajst-19178	46	18	fluorouracil	fluorouracil	NOUN
ajst-19178	46	19	and	and	CCONJ
ajst-19178	46	20	synergically	synergically	ADV
ajst-19178	46	21	inhibit	inhibit	VERB
ajst-19178	46	22	the	the	DET
ajst-19178	46	23	proliferative	proliferative	ADJ
ajst-19178	46	24	activity	activity	NOUN
ajst-19178	46	25	of	of	ADP
ajst-19178	46	26	cancer	cancer	NOUN
ajst-19178	46	27	cells	cell	NOUN
ajst-19178	46	28	,	,	PUNCT
ajst-19178	46	29	providing	provide	VERB
ajst-19178	46	30	a	a	DET
ajst-19178	46	31	new	new	ADJ
ajst-19178	46	32	treatment	treatment	NOUN
ajst-19178	46	33	option	option	NOUN
ajst-19178	46	34	for	for	ADP
ajst-19178	46	35	patients	patient	NOUN
ajst-19178	46	36	with	with	ADP
ajst-19178	46	37	colorectal	colorectal	ADJ
ajst-19178	46	38	cancer	cancer	NOUN
ajst-19178	46	39	[	[	X
ajst-19178	46	40	29	29	NUM
ajst-19178	46	41	]	]	PUNCT
ajst-19178	46	42	.	.	PUNCT
ajst-19178	47	1	art	art	NOUN
ajst-19178	47	2	combined	combine	VERB
ajst-19178	47	3	with	with	ADP
ajst-19178	47	4	cytarabine	cytarabine	NOUN
ajst-19178	47	5	can	can	AUX
ajst-19178	47	6	be	be	AUX
ajst-19178	47	7	used	use	VERB
ajst-19178	47	8	in	in	ADP
ajst-19178	47	9	the	the	DET
ajst-19178	47	10	treatment	treatment	NOUN
ajst-19178	47	11	of	of	ADP
ajst-19178	47	12	acute	acute	ADJ
ajst-19178	47	13	myeloid	myeloid	NOUN
ajst-19178	47	14	leukemia	leukemia	NOUN
ajst-19178	47	15	[	[	X
ajst-19178	47	16	30	30	NUM
ajst-19178	47	17	-	-	SYM
ajst-19178	47	18	32	32	NUM
ajst-19178	47	19	]	]	PUNCT
ajst-19178	47	20	.	.	PUNCT
ajst-19178	48	1	2.5	2.5	NUM
ajst-19178	48	2	.	.	PUNCT
ajst-19178	49	1	others	other	NOUN
ajst-19178	49	2	erlotinib	erlotinib	PROPN
ajst-19178	49	3	,	,	PUNCT
ajst-19178	49	4	a	a	DET
ajst-19178	49	5	tyrosine	tyrosine	NOUN
ajst-19178	49	6	kinase	kinase	NOUN
ajst-19178	49	7	inhibitor	inhibitor	NOUN
ajst-19178	49	8	of	of	ADP
ajst-19178	49	9	the	the	DET
ajst-19178	49	10	epidermal	epidermal	ADJ
ajst-19178	49	11	growth	growth	NOUN
ajst-19178	49	12	factor	factor	NOUN
ajst-19178	49	13	receptor	receptor	NOUN
ajst-19178	49	14	,	,	PUNCT
ajst-19178	49	15	binds	bind	VERB
ajst-19178	49	16	to	to	ADP
ajst-19178	49	17	the	the	DET
ajst-19178	49	18	adenosine	adenosine	ADJ
ajst-19178	49	19	triphosphate	triphosphate	NOUN
ajst-19178	49	20	binding	bind	VERB
ajst-19178	49	21	pocket	pocket	NOUN
ajst-19178	49	22	of	of	ADP
ajst-19178	49	23	mutated	mutate	VERB
ajst-19178	49	24	egfr	egfr	NOUN
ajst-19178	49	25	,	,	PUNCT
ajst-19178	49	26	impedes	impede	VERB
ajst-19178	49	27	egfr	egfr	ADJ
ajst-19178	49	28	phosphorylation	phosphorylation	NOUN
ajst-19178	49	29	and	and	CCONJ
ajst-19178	49	30	thus	thus	ADV
ajst-19178	49	31	inhibits	inhibit	VERB
ajst-19178	49	32	downstream	downstream	ADJ
ajst-19178	49	33	signaling	signal	VERB
ajst-19178	49	34	pathway	pathway	NOUN
ajst-19178	49	35	activation	activation	NOUN
ajst-19178	49	36	,	,	PUNCT
ajst-19178	49	37	and	and	CCONJ
ajst-19178	49	38	is	be	AUX
ajst-19178	49	39	currently	currently	ADV
ajst-19178	49	40	mainly	mainly	ADV
ajst-19178	49	41	used	use	VERB
ajst-19178	49	42	in	in	ADP
ajst-19178	49	43	the	the	DET
ajst-19178	49	44	treatment	treatment	NOUN
ajst-19178	49	45	of	of	ADP
ajst-19178	49	46	non	non	ADJ
ajst-19178	49	47	-	-	ADJ
ajst-19178	49	48	small	small	ADJ
ajst-19178	49	49	cell	cell	NOUN
ajst-19178	49	50	carcinoma	carcinoma	NOUN
ajst-19178	49	51	.	.	PUNCT
ajst-19178	50	1	the	the	DET
ajst-19178	50	2	combination	combination	NOUN
ajst-19178	50	3	of	of	ADP
ajst-19178	50	4	art	art	NOUN
ajst-19178	50	5	and	and	CCONJ
ajst-19178	50	6	erlotinib	erlotinib	NOUN
ajst-19178	50	7	has	have	VERB
ajst-19178	50	8	a	a	DET
ajst-19178	50	9	synergistic	synergistic	ADJ
ajst-19178	50	10	inhibitory	inhibitory	ADJ
ajst-19178	50	11	effect	effect	NOUN
ajst-19178	50	12	on	on	ADP
ajst-19178	50	13	tumor	tumor	NOUN
ajst-19178	50	14	cells	cell	NOUN
ajst-19178	50	15	[	[	X
ajst-19178	50	16	33	33	NUM
ajst-19178	50	17	]	]	PUNCT
ajst-19178	50	18	.	.	PUNCT
ajst-19178	51	1	sorafenib	sorafenib	PROPN
ajst-19178	51	2	,	,	PUNCT
ajst-19178	51	3	a	a	DET
ajst-19178	51	4	multi	multi	ADJ
ajst-19178	51	5	-	-	ADJ
ajst-19178	51	6	kinase	kinase	ADJ
ajst-19178	51	7	inhibitor	inhibitor	NOUN
ajst-19178	51	8	,	,	PUNCT
ajst-19178	51	9	is	be	AUX
ajst-19178	51	10	currently	currently	ADV
ajst-19178	51	11	the	the	DET
ajst-19178	51	12	standard	standard	ADJ
ajst-19178	51	13	chemotherapy	chemotherapy	NOUN
ajst-19178	51	14	drug	drug	NOUN
ajst-19178	51	15	for	for	ADP
ajst-19178	51	16	the	the	DET
ajst-19178	51	17	treatment	treatment	NOUN
ajst-19178	51	18	of	of	ADP
ajst-19178	51	19	advanced	advanced	ADJ
ajst-19178	51	20	liver	liver	NOUN
ajst-19178	51	21	cancer	cancer	NOUN
ajst-19178	51	22	,	,	PUNCT
ajst-19178	51	23	but	but	CCONJ
ajst-19178	51	24	its	its	PRON
ajst-19178	51	25	efficacy	efficacy	NOUN
ajst-19178	51	26	is	be	AUX
ajst-19178	51	27	limited	limited	ADJ
ajst-19178	51	28	and	and	CCONJ
ajst-19178	51	29	drug	drug	NOUN
ajst-19178	51	30	resistance	resistance	NOUN
ajst-19178	51	31	is	be	AUX
ajst-19178	51	32	easy	easy	ADJ
ajst-19178	51	33	to	to	PART
ajst-19178	51	34	occur	occur	VERB
ajst-19178	51	35	.	.	PUNCT
ajst-19178	52	1	the	the	DET
ajst-19178	52	2	combination	combination	NOUN
ajst-19178	52	3	of	of	ADP
ajst-19178	52	4	art	art	NOUN
ajst-19178	52	5	and	and	CCONJ
ajst-19178	52	6	sorafenib	sorafenib	NOUN
ajst-19178	52	7	has	have	VERB
ajst-19178	52	8	a	a	DET
ajst-19178	52	9	synergistic	synergistic	ADJ
ajst-19178	52	10	effect	effect	NOUN
ajst-19178	52	11	,	,	PUNCT
ajst-19178	52	12	and	and	CCONJ
ajst-19178	52	13	the	the	DET
ajst-19178	52	14	combination	combination	NOUN
ajst-19178	52	15	of	of	ADP
ajst-19178	52	16	the	the	DET
ajst-19178	52	17	two	two	NUM
ajst-19178	52	18	drugs	drug	NOUN
ajst-19178	52	19	can	can	AUX
ajst-19178	52	20	significantly	significantly	ADV
ajst-19178	52	21	enhance	enhance	VERB
ajst-19178	52	22	the	the	DET
ajst-19178	52	23	inhibition	inhibition	NOUN
ajst-19178	52	24	of	of	ADP
ajst-19178	52	25	tumor	tumor	NOUN
ajst-19178	53	1	[	[	X
ajst-19178	53	2	34	34	NUM
ajst-19178	53	3	]	]	PUNCT
ajst-19178	53	4	.	.	PUNCT
ajst-19178	54	1	3	3	X
ajst-19178	54	2	.	.	X
ajst-19178	54	3	anti	anti	ADJ
ajst-19178	54	4	-	-	ADJ
ajst-19178	54	5	tumor	tumor	ADJ
ajst-19178	54	6	mechanism	mechanism	NOUN
ajst-19178	54	7	of	of	ADP
ajst-19178	54	8	artesunate	artesunate	ADJ
ajst-19178	54	9	combineddrugs	combineddrug	NOUN
ajst-19178	54	10	3.1	3.1	NUM
ajst-19178	54	11	.	.	PUNCT
ajst-19178	55	1	induced	induce	VERB
ajst-19178	55	2	iron	iron	NOUN
ajst-19178	55	3	death	death	NOUN
ajst-19178	55	4	of	of	ADP
ajst-19178	55	5	tumor	tumor	NOUN
ajst-19178	55	6	cells	cell	NOUN
ajst-19178	55	7	studies	study	NOUN
ajst-19178	55	8	have	have	AUX
ajst-19178	55	9	shown	show	VERB
ajst-19178	55	10	that	that	SCONJ
ajst-19178	55	11	the	the	DET
ajst-19178	55	12	combination	combination	NOUN
ajst-19178	55	13	of	of	ADP
ajst-19178	55	14	art	art	NOUN
ajst-19178	55	15	and	and	CCONJ
ajst-19178	55	16	sorafenib	sorafenib	NOUN
ajst-19178	55	17	more	more	ADV
ajst-19178	55	18	significantly	significantly	ADV
ajst-19178	55	19	inhibited	inhibit	VERB
ajst-19178	55	20	the	the	DET
ajst-19178	55	21	proliferation	proliferation	NOUN
ajst-19178	55	22	of	of	ADP
ajst-19178	55	23	hepg2	hepg2	NOUN
ajst-19178	55	24	cells	cell	NOUN
ajst-19178	55	25	and	and	CCONJ
ajst-19178	55	26	in	in	ADP
ajst-19178	55	27	vivo	vivo	ADJ
ajst-19178	55	28	tumors	tumor	NOUN
ajst-19178	55	29	,	,	PUNCT
ajst-19178	55	30	and	and	CCONJ
ajst-19178	55	31	the	the	DET
ajst-19178	55	32	combination	combination	NOUN
ajst-19178	55	33	therapy	therapy	NOUN
ajst-19178	55	34	induced	induce	VERB
ajst-19178	55	35	lipid	lipid	NOUN
ajst-19178	55	36	peroxidation	peroxidation	NOUN
ajst-19178	55	37	and	and	CCONJ
ajst-19178	55	38	iron	iron	NOUN
ajst-19178	55	39	death	death	NOUN
ajst-19178	55	40	compared	compare	VERB
ajst-19178	55	41	with	with	ADP
ajst-19178	55	42	drug	drug	NOUN
ajst-19178	55	43	alone	alone	ADV
ajst-19178	55	44	.	.	PUNCT
ajst-19178	56	1	art	art	NOUN
ajst-19178	56	2	can	can	AUX
ajst-19178	56	3	enhance	enhance	VERB
ajst-19178	56	4	the	the	DET
ajst-19178	56	5	sensitivity	sensitivity	NOUN
ajst-19178	56	6	of	of	ADP
ajst-19178	56	7	hepatocellular	hepatocellular	ADJ
ajst-19178	56	8	carcinoma	carcinoma	NOUN
ajst-19178	56	9	cells	cell	NOUN
ajst-19178	56	10	to	to	AUX
ajst-19178	56	11	sorafenib	sorafenib	NOUN
ajst-19178	56	12	and	and	CCONJ
ajst-19178	56	13	has	have	VERB
ajst-19178	56	14	a	a	DET
ajst-19178	56	15	synergistic	synergistic	ADJ
ajst-19178	56	16	anticancer	anticancer	NOUN
ajst-19178	56	17	effect	effect	NOUN
ajst-19178	56	18	when	when	SCONJ
ajst-19178	56	19	combined	combine	VERB
ajst-19178	56	20	with	with	ADP
ajst-19178	56	21	sorafenib	sorafenib	NOUN
ajst-19178	56	22	.	.	PUNCT
ajst-19178	57	1	combined	combine	VERB
ajst-19178	57	2	therapy	therapy	NOUN
ajst-19178	57	3	can	can	AUX
ajst-19178	57	4	reduce	reduce	VERB
ajst-19178	57	5	the	the	DET
ajst-19178	57	6	synthesis	synthesis	NOUN
ajst-19178	57	7	of	of	ADP
ajst-19178	57	8	gsh	gsh	NOUN
ajst-19178	57	9	and	and	CCONJ
ajst-19178	57	10	increase	increase	VERB
ajst-19178	57	11	the	the	DET
ajst-19178	57	12	production	production	NOUN
ajst-19178	57	13	of	of	ADP
ajst-19178	57	14	ros	ros	PROPN
ajst-19178	57	15	,	,	PUNCT
ajst-19178	57	16	thus	thus	ADV
ajst-19178	57	17	reducing	reduce	VERB
ajst-19178	57	18	mitochondrial	mitochondrial	ADJ
ajst-19178	57	19	potential	potential	ADJ
ajst-19178	57	20	and	and	CCONJ
ajst-19178	57	21	damaging	damaging	ADJ
ajst-19178	57	22	mitochondrial	mitochondrial	ADJ
ajst-19178	57	23	function	function	NOUN
ajst-19178	57	24	.	.	PUNCT
ajst-19178	58	1	the	the	DET
ajst-19178	58	2	activation	activation	NOUN
ajst-19178	58	3	of	of	ADP
ajst-19178	58	4	cathepsin	cathepsin	NOUN
ajst-19178	58	5	b	b	PROPN
ajst-19178	58	6	/	/	SYM
ajst-19178	58	7	l	l	NOUN
ajst-19178	58	8	and	and	CCONJ
ajst-19178	58	9	the	the	DET
ajst-19178	58	10	degradation	degradation	NOUN
ajst-19178	58	11	of	of	ADP
ajst-19178	58	12	ferritin	ferritin	ADJ
ajst-19178	58	13	were	be	AUX
ajst-19178	58	14	induced	induce	VERB
ajst-19178	58	15	.	.	PUNCT
ajst-19178	59	1	the	the	DET
ajst-19178	59	2	two	two	NUM
ajst-19178	59	3	synergistically	synergistically	ADV
ajst-19178	59	4	reduce	reduce	VERB
ajst-19178	59	5	the	the	DET
ajst-19178	59	6	expression	expression	NOUN
ajst-19178	59	7	of	of	ADP
ajst-19178	59	8	tfrc	tfrc	NOUN
ajst-19178	59	9	along	along	ADP
ajst-19178	59	10	with	with	ADP
ajst-19178	59	11	the	the	DET
ajst-19178	59	12	degradation	degradation	NOUN
ajst-19178	59	13	of	of	ADP
ajst-19178	59	14	ftl	ftl	NOUN
ajst-19178	59	15	and	and	CCONJ
ajst-19178	59	16	fth	fth	NOUN
ajst-19178	59	17	,	,	PUNCT
ajst-19178	59	18	promoting	promote	VERB
ajst-19178	59	19	liver	liver	NOUN
ajst-19178	59	20	cancer	cancer	NOUN
ajst-19178	59	21	cells	cell	NOUN
ajst-19178	59	22	towards	towards	ADP
ajst-19178	59	23	iron	iron	NOUN
ajst-19178	59	24	death	death	NOUN
ajst-19178	59	25	[	[	X
ajst-19178	59	26	35	35	NUM
ajst-19178	59	27	]	]	SYM
ajst-19178	59	28	.	.	PUNCT
ajst-19178	60	1	3.2	3.2	NUM
ajst-19178	60	2	.	.	PUNCT
ajst-19178	60	3	induction	induction	NOUN
ajst-19178	60	4	of	of	ADP
ajst-19178	60	5	tumor	tumor	NOUN
ajst-19178	60	6	cell	cell	NOUN
ajst-19178	60	7	apoptosis	apoptosis	NOUN
ajst-19178	60	8	baicalein	baicalein	PROPN
ajst-19178	60	9	is	be	AUX
ajst-19178	60	10	a	a	DET
ajst-19178	60	11	kind	kind	NOUN
ajst-19178	60	12	of	of	ADP
ajst-19178	60	13	flavonoid	flavonoid	NOUN
ajst-19178	60	14	compound	compound	PROPN
ajst-19178	60	15	.	.	PUNCT
ajst-19178	61	1	both	both	DET
ajst-19178	61	2	art	art	NOUN
ajst-19178	61	3	and	and	CCONJ
ajst-19178	61	4	baicalein	baicalein	NOUN
ajst-19178	61	5	have	have	VERB
ajst-19178	61	6	anticancer	anticancer	NOUN
ajst-19178	61	7	effect	effect	NOUN
ajst-19178	61	8	,	,	PUNCT
ajst-19178	61	9	and	and	CCONJ
ajst-19178	61	10	they	they	PRON
ajst-19178	61	11	have	have	VERB
ajst-19178	61	12	synergistic	synergistic	ADJ
ajst-19178	61	13	effect	effect	NOUN
ajst-19178	61	14	when	when	SCONJ
ajst-19178	61	15	used	use	VERB
ajst-19178	61	16	together	together	ADV
ajst-19178	61	17	.	.	PUNCT
ajst-19178	62	1	compared	compare	VERB
ajst-19178	62	2	with	with	ADP
ajst-19178	62	3	single	single	ADJ
ajst-19178	62	4	therapy	therapy	NOUN
ajst-19178	62	5	,	,	PUNCT
ajst-19178	62	6	combination	combination	NOUN
ajst-19178	62	7	therapy	therapy	NOUN
ajst-19178	62	8	increased	increase	VERB
ajst-19178	62	9	the	the	DET
ajst-19178	62	10	cleavage	cleavage	NOUN
ajst-19178	62	11	of	of	ADP
ajst-19178	62	12	caspase	caspase	PROPN
ajst-19178	62	13	3	3	NUM
ajst-19178	62	14	and	and	CCONJ
ajst-19178	62	15	parp	parp	NOUN
ajst-19178	62	16	in	in	ADP
ajst-19178	62	17	liver	liver	NOUN
ajst-19178	62	18	cancer	cancer	NOUN
ajst-19178	62	19	cells	cell	NOUN
ajst-19178	62	20	and	and	CCONJ
ajst-19178	62	21	increased	increase	VERB
ajst-19178	62	22	the	the	DET
ajst-19178	62	23	expression	expression	NOUN
ajst-19178	62	24	of	of	ADP
ajst-19178	62	25	dna	dna	PROPN
ajst-19178	62	26	damage	damage	NOUN
ajst-19178	62	27	inducing	induce	VERB
ajst-19178	62	28	factor	factor	NOUN
ajst-19178	62	29	(	(	PUNCT
ajst-19178	62	30	gadd45a	gadd45a	NOUN
ajst-19178	62	31	)	)	PUNCT
ajst-19178	62	32	,	,	PUNCT
ajst-19178	62	33	tnf	tnf	PROPN
ajst-19178	62	34	-	-	PUNCT
ajst-19178	62	35	α	α	PROPN
ajst-19178	62	36	and	and	CCONJ
ajst-19178	62	37	tnfreceptor	tnfreceptor	NOUN
ajst-19178	62	38	-	-	PUNCT
ajst-19178	62	39	associated	associate	VERB
ajst-19178	62	40	factor	factor	NOUN
ajst-19178	62	41	3	3	NUM
ajst-19178	62	42	(	(	PUNCT
ajst-19178	62	43	traf3	traf3	NOUN
ajst-19178	62	44	)	)	PUNCT
ajst-19178	62	45	.	.	PUNCT
ajst-19178	63	1	reduce	reduce	VERB
ajst-19178	63	2	liver	liver	NOUN
ajst-19178	63	3	cancer	cancer	NOUN
ajst-19178	63	4	cell	cell	NOUN
ajst-19178	63	5	activity	activity	NOUN
ajst-19178	63	6	to	to	PART
ajst-19178	63	7	induce	induce	VERB
ajst-19178	63	8	apoptosis	apoptosis	NOUN
ajst-19178	63	9	[	[	X
ajst-19178	63	10	36	36	NUM
ajst-19178	63	11	]	]	PUNCT
ajst-19178	63	12	.	.	PUNCT
ajst-19178	64	1	the	the	DET
ajst-19178	64	2	combination	combination	NOUN
ajst-19178	64	3	of	of	ADP
ajst-19178	64	4	art	art	NOUN
ajst-19178	64	5	and	and	CCONJ
ajst-19178	64	6	temozolomide	temozolomide	NOUN
ajst-19178	64	7	to	to	PART
ajst-19178	64	8	form	form	VERB
ajst-19178	64	9	targeted	target	VERB
ajst-19178	64	10	liposomes	liposome	NOUN
ajst-19178	64	11	can	can	AUX
ajst-19178	64	12	improve	improve	VERB
ajst-19178	64	13	the	the	DET
ajst-19178	64	14	sensitivity	sensitivity	NOUN
ajst-19178	64	15	of	of	ADP
ajst-19178	64	16	u251	u251	PROPN
ajst-19178	64	17	-	-	PUNCT
ajst-19178	64	18	tr	tr	VERB
ajst-19178	64	19	glioma	glioma	NOUN
ajst-19178	64	20	to	to	PART
ajst-19178	64	21	temozolomide	temozolomide	VERB
ajst-19178	64	22	.	.	PUNCT
ajst-19178	65	1	targeted	target	VERB
ajst-19178	65	2	liposomes	liposome	NOUN
ajst-19178	65	3	inhibited	inhibit	VERB
ajst-19178	65	4	mgmt	mgmt	ADJ
ajst-19178	65	5	protein	protein	NOUN
ajst-19178	65	6	expression	expression	NOUN
ajst-19178	65	7	by	by	ADP
ajst-19178	65	8	interfering	interfere	VERB
ajst-19178	65	9	with	with	ADP
ajst-19178	65	10	wnt	wnt	NOUN
ajst-19178	65	11	/	/	SYM
ajst-19178	65	12	β	β	NOUN
ajst-19178	65	13	-	-	NOUN
ajst-19178	65	14	catenin	catenin	NOUN
ajst-19178	65	15	,	,	PUNCT
ajst-19178	65	16	while	while	SCONJ
ajst-19178	65	17	enhancing	enhance	VERB
ajst-19178	65	18	dna	dna	NOUN
ajst-19178	65	19	damage	damage	NOUN
ajst-19178	65	20	,	,	PUNCT
ajst-19178	65	21	which	which	PRON
ajst-19178	65	22	synergistically	synergistically	ADV
ajst-19178	65	23	enhanced	enhance	VERB
ajst-19178	65	24	the	the	DET
ajst-19178	65	25	pro	pro	ADJ
ajst-19178	65	26	-	-	ADJ
ajst-19178	65	27	apoptotic	apoptotic	ADJ
ajst-19178	65	28	effect	effect	NOUN
ajst-19178	65	29	.	.	PUNCT
ajst-19178	66	1	liposomes	liposome	NOUN
ajst-19178	66	2	can	can	AUX
ajst-19178	66	3	deliver	deliver	VERB
ajst-19178	66	4	drugs	drug	NOUN
ajst-19178	66	5	deep	deep	ADV
ajst-19178	66	6	into	into	ADP
ajst-19178	66	7	tumors	tumor	NOUN
ajst-19178	66	8	through	through	ADP
ajst-19178	66	9	the	the	DET
ajst-19178	66	10	blood	blood	NOUN
ajst-19178	66	11	-	-	PUNCT
ajst-19178	66	12	brain	brain	NOUN
ajst-19178	66	13	barrier	barrier	NOUN
ajst-19178	66	14	,	,	PUNCT
ajst-19178	66	15	and	and	CCONJ
ajst-19178	66	16	can	can	AUX
ajst-19178	66	17	effectively	effectively	ADV
ajst-19178	66	18	reduce	reduce	VERB
ajst-19178	66	19	the	the	DET
ajst-19178	66	20	effective	effective	ADJ
ajst-19178	66	21	dose	dose	NOUN
ajst-19178	66	22	of	of	ADP
ajst-19178	66	23	temozolomide	temozolomide	NOUN
ajst-19178	66	24	and	and	CCONJ
ajst-19178	66	25	reduce	reduce	VERB
ajst-19178	66	26	the	the	DET
ajst-19178	66	27	toxic	toxic	ADJ
ajst-19178	66	28	effects	effect	NOUN
ajst-19178	66	29	of	of	ADP
ajst-19178	66	30	temozolomide	temozolomide	NOUN
ajst-19178	66	31	[	[	X
ajst-19178	66	32	15	15	NUM
ajst-19178	66	33	]	]	PUNCT
ajst-19178	66	34	.	.	PUNCT
ajst-19178	67	1	the	the	DET
ajst-19178	67	2	combination	combination	NOUN
ajst-19178	67	3	of	of	ADP
ajst-19178	67	4	art	art	NOUN
ajst-19178	67	5	and	and	CCONJ
ajst-19178	67	6	cisplatin	cisplatin	NOUN
ajst-19178	67	7	can	can	AUX
ajst-19178	67	8	inhibit	inhibit	VERB
ajst-19178	67	9	the	the	DET
ajst-19178	67	10	proliferation	proliferation	NOUN
ajst-19178	67	11	of	of	ADP
ajst-19178	67	12	a549	a549	PROPN
ajst-19178	67	13	cells	cell	NOUN
ajst-19178	67	14	.	.	PUNCT
ajst-19178	68	1	compared	compare	VERB
ajst-19178	68	2	with	with	ADP
ajst-19178	68	3	the	the	DET
ajst-19178	68	4	single	single	ADJ
ajst-19178	68	5	treatment	treatment	NOUN
ajst-19178	68	6	of	of	ADP
ajst-19178	68	7	art	art	NOUN
ajst-19178	68	8	and	and	CCONJ
ajst-19178	68	9	cisplatin	cisplatin	NOUN
ajst-19178	68	10	,	,	PUNCT
ajst-19178	68	11	the	the	DET
ajst-19178	68	12	combination	combination	NOUN
ajst-19178	68	13	treatment	treatment	NOUN
ajst-19178	68	14	can	can	AUX
ajst-19178	68	15	increase	increase	VERB
ajst-19178	68	16	the	the	DET
ajst-19178	68	17	expression	expression	NOUN
ajst-19178	68	18	of	of	ADP
ajst-19178	68	19	p21	p21	NOUN
ajst-19178	68	20	,	,	PUNCT
ajst-19178	68	21	decrease	decrease	VERB
ajst-19178	68	22	the	the	DET
ajst-19178	68	23	expression	expression	NOUN
ajst-19178	68	24	of	of	ADP
ajst-19178	68	25	cyclinb1	cyclinb1	NOUN
ajst-19178	68	26	and	and	CCONJ
ajst-19178	68	27	p34	p34	VERB
ajst-19178	68	28	,	,	PUNCT
ajst-19178	68	29	increase	increase	VERB
ajst-19178	68	30	the	the	DET
ajst-19178	68	31	expression	expression	NOUN
ajst-19178	68	32	of	of	ADP
ajst-19178	68	33	p53	p53	NOUN
ajst-19178	68	34	and	and	CCONJ
ajst-19178	68	35	bax	bax	NOUN
ajst-19178	68	36	,	,	PUNCT
ajst-19178	68	37	and	and	CCONJ
ajst-19178	68	38	decrease	decrease	VERB
ajst-19178	68	39	the	the	DET
ajst-19178	68	40	expression	expression	NOUN
ajst-19178	68	41	of	of	ADP
ajst-19178	68	42	bcl-2	bcl-2	NOUN
ajst-19178	68	43	.	.	PUNCT
ajst-19178	69	1	enhance	enhance	VERB
ajst-19178	69	2	the	the	DET
ajst-19178	69	3	activities	activity	NOUN
ajst-19178	69	4	of	of	ADP
ajst-19178	69	5	caspase-3	caspase-3	NUM
ajst-19178	69	6	,	,	PUNCT
ajst-19178	69	7	caspase-7	caspase-7	NUM
ajst-19178	69	8	and	and	CCONJ
ajst-19178	69	9	caspase-9	caspase-9	NUM
ajst-19178	69	10	,	,	PUNCT
ajst-19178	69	11	and	and	CCONJ
ajst-19178	69	12	synergically	synergically	ADV
ajst-19178	69	13	regulate	regulate	VERB
ajst-19178	69	14	the	the	DET
ajst-19178	69	15	activity	activity	NOUN
ajst-19178	69	16	of	of	ADP
ajst-19178	69	17	p38	p38	NOUN
ajst-19178	69	18	/	/	SYM
ajst-19178	69	19	jnk	jnk	PROPN
ajst-19178	69	20	/	/	SYM
ajst-19178	69	21	erk1/2	erk1/2	PROPN
ajst-19178	69	22	mapk	mapk	NOUN
ajst-19178	69	23	pathway	pathway	NOUN
ajst-19178	69	24	,	,	PUNCT
ajst-19178	69	25	inducing	induce	VERB
ajst-19178	69	26	cell	cell	NOUN
ajst-19178	69	27	apoptosis	apoptosis	NOUN
ajst-19178	69	28	[	[	X
ajst-19178	69	29	25	25	NUM
ajst-19178	69	30	]	]	PUNCT
ajst-19178	69	31	.	.	PUNCT
ajst-19178	70	1	both	both	DET
ajst-19178	70	2	art	art	NOUN
ajst-19178	70	3	and	and	CCONJ
ajst-19178	70	4	carboplatin	carboplatin	NOUN
ajst-19178	70	5	can	can	AUX
ajst-19178	70	6	inhibit	inhibit	VERB
ajst-19178	70	7	the	the	DET
ajst-19178	70	8	activity	activity	NOUN
ajst-19178	70	9	of	of	ADP
ajst-19178	70	10	a549	a549	PROPN
ajst-19178	70	11	cells	cell	NOUN
ajst-19178	70	12	,	,	PUNCT
ajst-19178	70	13	and	and	CCONJ
ajst-19178	70	14	the	the	DET
ajst-19178	70	15	combination	combination	NOUN
ajst-19178	70	16	of	of	ADP
ajst-19178	70	17	the	the	DET
ajst-19178	70	18	two	two	NUM
ajst-19178	70	19	can	can	AUX
ajst-19178	70	20	significantly	significantly	ADV
ajst-19178	70	21	enhance	enhance	VERB
ajst-19178	70	22	the	the	DET
ajst-19178	70	23	apoptosis	apoptosis	NOUN
ajst-19178	70	24	rate	rate	NOUN
ajst-19178	70	25	of	of	ADP
ajst-19178	70	26	tumor	tumor	NOUN
ajst-19178	70	27	cells	cell	NOUN
ajst-19178	70	28	.	.	PUNCT
ajst-19178	71	1	the	the	DET
ajst-19178	71	2	combination	combination	NOUN
ajst-19178	71	3	of	of	ADP
ajst-19178	71	4	low	low	ADJ
ajst-19178	71	5	concentration	concentration	NOUN
ajst-19178	71	6	art	art	NOUN
ajst-19178	71	7	and	and	CCONJ
ajst-19178	71	8	carboplatin	carboplatin	NOUN
ajst-19178	71	9	showed	show	VERB
ajst-19178	71	10	a	a	DET
ajst-19178	71	11	synergistic	synergistic	ADJ
ajst-19178	71	12	effect	effect	NOUN
ajst-19178	71	13	,	,	PUNCT
ajst-19178	71	14	which	which	PRON
ajst-19178	71	15	significantly	significantly	ADV
ajst-19178	71	16	inhibited	inhibit	VERB
ajst-19178	71	17	cell	cell	NOUN
ajst-19178	71	18	proliferation	proliferation	NOUN
ajst-19178	71	19	,	,	PUNCT
ajst-19178	71	20	promoted	promote	VERB
ajst-19178	71	21	cell	cell	NOUN
ajst-19178	71	22	cycle	cycle	NOUN
ajst-19178	71	23	arrest	arrest	NOUN
ajst-19178	71	24	in	in	ADP
ajst-19178	71	25	g2	g2	PROPN
ajst-19178	71	26	/m	/m	PUNCT
ajst-19178	71	27	phase	phase	NOUN
ajst-19178	71	28	,	,	PUNCT
ajst-19178	71	29	increased	increase	VERB
ajst-19178	71	30	the	the	DET
ajst-19178	71	31	199	199	NUM
ajst-19178	71	32	expressions	expression	NOUN
ajst-19178	71	33	of	of	ADP
ajst-19178	71	34	bax	bax	PROPN
ajst-19178	71	35	,	,	PUNCT
ajst-19178	71	36	p21	p21	NOUN
ajst-19178	71	37	,	,	PUNCT
ajst-19178	71	38	p53	p53	NOUN
ajst-19178	71	39	and	and	CCONJ
ajst-19178	71	40	caspase-3	caspase-3	NUM
ajst-19178	71	41	,	,	PUNCT
ajst-19178	71	42	and	and	CCONJ
ajst-19178	71	43	decreased	decrease	VERB
ajst-19178	71	44	the	the	DET
ajst-19178	71	45	expressions	expression	NOUN
ajst-19178	71	46	of	of	ADP
ajst-19178	71	47	bcl-2	bcl-2	NOUN
ajst-19178	71	48	and	and	CCONJ
ajst-19178	71	49	cyclin	cyclin	NOUN
ajst-19178	71	50	b1	b1	PROPN
ajst-19178	71	51	.	.	PUNCT
ajst-19178	72	1	it	it	PRON
ajst-19178	72	2	plays	play	VERB
ajst-19178	72	3	a	a	DET
ajst-19178	72	4	synergistic	synergistic	ADJ
ajst-19178	72	5	role	role	NOUN
ajst-19178	72	6	in	in	ADP
ajst-19178	72	7	non	non	ADJ
ajst-19178	72	8	-	-	ADJ
ajst-19178	72	9	small	small	ADJ
ajst-19178	72	10	cell	cell	NOUN
ajst-19178	72	11	lung	lung	NOUN
ajst-19178	72	12	cancer	cancer	NOUN
ajst-19178	72	13	by	by	ADP
ajst-19178	72	14	enhancing	enhance	VERB
ajst-19178	72	15	mitochondriadependent	mitochondriadependent	ADJ
ajst-19178	72	16	apoptosis	apoptosis	NOUN
ajst-19178	72	17	[	[	X
ajst-19178	72	18	26	26	NUM
ajst-19178	72	19	]	]	PUNCT
ajst-19178	72	20	.	.	PUNCT
ajst-19178	73	1	both	both	DET
ajst-19178	73	2	art	art	NOUN
ajst-19178	73	3	and	and	CCONJ
ajst-19178	73	4	5	5	NUM
ajst-19178	73	5	-	-	PUNCT
ajst-19178	73	6	fluorouracil	fluorouracil	NOUN
ajst-19178	73	7	had	have	VERB
ajst-19178	73	8	inhibitory	inhibitory	ADJ
ajst-19178	73	9	effects	effect	NOUN
ajst-19178	73	10	on	on	ADP
ajst-19178	73	11	hct116	hct116	PROPN
ajst-19178	73	12	cells	cell	NOUN
ajst-19178	73	13	,	,	PUNCT
ajst-19178	73	14	and	and	CCONJ
ajst-19178	73	15	the	the	DET
ajst-19178	73	16	antitumor	antitumor	PROPN
ajst-19178	73	17	activity	activity	NOUN
ajst-19178	73	18	of	of	ADP
ajst-19178	73	19	art	art	NOUN
ajst-19178	73	20	combined	combine	VERB
ajst-19178	73	21	with	with	ADP
ajst-19178	73	22	5	5	NUM
ajst-19178	73	23	-	-	PUNCT
ajst-19178	73	24	fluorouracil	fluorouracil	NOUN
ajst-19178	73	25	was	be	AUX
ajst-19178	73	26	significantly	significantly	ADV
ajst-19178	73	27	higher	high	ADJ
ajst-19178	73	28	than	than	ADP
ajst-19178	73	29	that	that	PRON
ajst-19178	73	30	of	of	ADP
ajst-19178	73	31	5fluorouracil	5fluorouracil	NUM
ajst-19178	73	32	alone	alone	ADJ
ajst-19178	73	33	.	.	PUNCT
ajst-19178	74	1	combined	combine	VERB
ajst-19178	74	2	use	use	NOUN
ajst-19178	74	3	of	of	ADP
ajst-19178	74	4	the	the	DET
ajst-19178	74	5	two	two	NUM
ajst-19178	74	6	decreased	decrease	VERB
ajst-19178	74	7	pcna	pcna	NOUN
ajst-19178	74	8	,	,	PUNCT
ajst-19178	74	9	ki-67	ki-67	X
ajst-19178	74	10	,	,	PUNCT
ajst-19178	74	11	and	and	CCONJ
ajst-19178	74	12	bcl-2	bcl-2	NOUN
ajst-19178	74	13	levels	level	NOUN
ajst-19178	74	14	,	,	PUNCT
ajst-19178	74	15	and	and	CCONJ
ajst-19178	74	16	increased	increase	VERB
ajst-19178	74	17	cleaved	cleaved	ADJ
ajst-19178	74	18	caspase-3	caspase-3	NUM
ajst-19178	74	19	levels	level	NOUN
ajst-19178	74	20	.	.	PUNCT
ajst-19178	75	1	art	art	NOUN
ajst-19178	75	2	significantly	significantly	ADV
ajst-19178	75	3	enhanced	enhance	VERB
ajst-19178	75	4	the	the	DET
ajst-19178	75	5	sensitivity	sensitivity	NOUN
ajst-19178	75	6	of	of	ADP
ajst-19178	75	7	tumor	tumor	NOUN
ajst-19178	75	8	cells	cell	NOUN
ajst-19178	75	9	to	to	ADP
ajst-19178	75	10	5	5	NUM
ajst-19178	75	11	-	-	PUNCT
ajst-19178	75	12	fluorouracil	fluorouracil	NOUN
ajst-19178	75	13	and	and	CCONJ
ajst-19178	75	14	increased	increase	VERB
ajst-19178	75	15	the	the	DET
ajst-19178	75	16	apoptosis	apoptosis	NOUN
ajst-19178	75	17	of	of	ADP
ajst-19178	75	18	tumor	tumor	NOUN
ajst-19178	75	19	cells	cell	NOUN
ajst-19178	75	20	[	[	X
ajst-19178	75	21	29	29	NUM
ajst-19178	75	22	]	]	PUNCT
ajst-19178	75	23	.	.	PUNCT
ajst-19178	76	1	art	art	NOUN
ajst-19178	76	2	and	and	CCONJ
ajst-19178	76	3	ginsenoside	ginsenoside	PROPN
ajst-19178	76	4	rg3	rg3	PROPN
ajst-19178	76	5	synergistically	synergistically	ADV
ajst-19178	76	6	reduce	reduce	VERB
ajst-19178	76	7	the	the	DET
ajst-19178	76	8	survival	survival	NOUN
ajst-19178	76	9	rate	rate	NOUN
ajst-19178	76	10	of	of	ADP
ajst-19178	76	11	sorafenib	sorafenib	NOUN
ajst-19178	76	12	resistant	resistant	ADJ
ajst-19178	76	13	hepg2	hepg2	VERB
ajst-19178	76	14	liver	liver	NOUN
ajst-19178	76	15	cancer	cancer	NOUN
ajst-19178	76	16	cells	cell	NOUN
ajst-19178	76	17	,	,	PUNCT
ajst-19178	76	18	significantly	significantly	ADV
ajst-19178	76	19	increase	increase	VERB
ajst-19178	76	20	cell	cell	NOUN
ajst-19178	76	21	ros	ros	PROPN
ajst-19178	76	22	,	,	PUNCT
ajst-19178	76	23	inhibit	inhibit	VERB
ajst-19178	76	24	the	the	DET
ajst-19178	76	25	phosphorylation	phosphorylation	NOUN
ajst-19178	76	26	of	of	ADP
ajst-19178	76	27	stat3	stat3	NOUN
ajst-19178	76	28	and	and	CCONJ
ajst-19178	76	29	its	its	PRON
ajst-19178	76	30	upstream	upstream	ADJ
ajst-19178	76	31	kinase	kinase	PROPN
ajst-19178	76	32	src	src	PROPN
ajst-19178	76	33	,	,	PUNCT
ajst-19178	76	34	reduce	reduce	VERB
ajst-19178	76	35	the	the	DET
ajst-19178	76	36	level	level	NOUN
ajst-19178	76	37	of	of	ADP
ajst-19178	76	38	stat3	stat3	NOUN
ajst-19178	76	39	,	,	PUNCT
ajst-19178	76	40	down	down	AUX
ajst-19178	76	41	-	-	PUNCT
ajst-19178	76	42	regulate	regulate	VERB
ajst-19178	76	43	the	the	DET
ajst-19178	76	44	protein	protein	NOUN
ajst-19178	76	45	levels	level	NOUN
ajst-19178	76	46	of	of	ADP
ajst-19178	76	47	mcl-1	mcl-1	NUM
ajst-19178	76	48	and	and	CCONJ
ajst-19178	76	49	bcl-2	bcl-2	VERB
ajst-19178	76	50	in	in	ADP
ajst-19178	76	51	hepg2	hepg2	NOUN
ajst-19178	76	52	cells	cell	NOUN
ajst-19178	76	53	,	,	PUNCT
ajst-19178	76	54	and	and	CCONJ
ajst-19178	76	55	induce	induce	VERB
ajst-19178	76	56	cell	cell	NOUN
ajst-19178	76	57	apoptosis	apoptosis	NOUN
ajst-19178	76	58	.	.	PUNCT
ajst-19178	77	1	it	it	PRON
ajst-19178	77	2	also	also	ADV
ajst-19178	77	3	inhibited	inhibit	VERB
ajst-19178	77	4	the	the	DET
ajst-19178	77	5	growth	growth	NOUN
ajst-19178	77	6	of	of	ADP
ajst-19178	77	7	hepg2	hepg2	PROPN
ajst-19178	77	8	-	-	PUNCT
ajst-19178	77	9	sr	sr	PROPN
ajst-19178	77	10	tumor	tumor	NOUN
ajst-19178	77	11	in	in	ADP
ajst-19178	77	12	mice	mouse	NOUN
ajst-19178	77	13	[	[	X
ajst-19178	77	14	37	37	NUM
ajst-19178	77	15	]	]	PUNCT
ajst-19178	77	16	.	.	PUNCT
ajst-19178	78	1	art	art	NOUN
ajst-19178	78	2	alone	alone	ADV
ajst-19178	78	3	inhibited	inhibit	VERB
ajst-19178	78	4	the	the	DET
ajst-19178	78	5	activity	activity	NOUN
ajst-19178	78	6	of	of	ADP
ajst-19178	78	7	c918	c918	PROPN
ajst-19178	78	8	cells	cell	NOUN
ajst-19178	78	9	and	and	CCONJ
ajst-19178	78	10	significantly	significantly	ADV
ajst-19178	78	11	increased	increase	VERB
ajst-19178	78	12	ros	ros	PROPN
ajst-19178	78	13	levels	level	NOUN
ajst-19178	78	14	,	,	PUNCT
ajst-19178	78	15	ldh	ldh	PROPN
ajst-19178	78	16	release	release	NOUN
ajst-19178	78	17	,	,	PUNCT
ajst-19178	78	18	caspase-3	caspase-3	NUM
ajst-19178	78	19	,	,	PUNCT
ajst-19178	78	20	caspase-9	caspase-9	PROPN
ajst-19178	78	21	,	,	PUNCT
ajst-19178	78	22	and	and	CCONJ
ajst-19178	78	23	il1b	il1b	PROPN
ajst-19178	78	24	and	and	CCONJ
ajst-19178	78	25	il18	il18	PROPN
ajst-19178	78	26	levels	level	NOUN
ajst-19178	78	27	.	.	PUNCT
ajst-19178	79	1	art	art	NOUN
ajst-19178	79	2	inhibits	inhibit	VERB
ajst-19178	79	3	the	the	DET
ajst-19178	79	4	activity	activity	NOUN
ajst-19178	79	5	of	of	ADP
ajst-19178	79	6	c918	c918	PROPN
ajst-19178	79	7	cells	cell	NOUN
ajst-19178	79	8	by	by	ADP
ajst-19178	79	9	inhibiting	inhibit	VERB
ajst-19178	79	10	malat1	malat1	PROPN
ajst-19178	79	11	/	/	SYM
ajst-19178	79	12	yap	yap	PROPN
ajst-19178	79	13	signaling	signal	VERB
ajst-19178	79	14	pathway	pathway	NOUN
ajst-19178	79	15	.	.	PUNCT
ajst-19178	80	1	however	however	ADV
ajst-19178	80	2	,	,	PUNCT
ajst-19178	80	3	the	the	DET
ajst-19178	80	4	combination	combination	NOUN
ajst-19178	80	5	of	of	ADP
ajst-19178	80	6	vitipofen	vitipofen	NOUN
ajst-19178	80	7	and	and	CCONJ
ajst-19178	80	8	art	art	NOUN
ajst-19178	80	9	can	can	AUX
ajst-19178	80	10	enhance	enhance	VERB
ajst-19178	80	11	the	the	DET
ajst-19178	80	12	inhibitory	inhibitory	ADJ
ajst-19178	80	13	effect	effect	NOUN
ajst-19178	80	14	of	of	ADP
ajst-19178	80	15	art	art	NOUN
ajst-19178	80	16	on	on	ADP
ajst-19178	80	17	c918	c918	PROPN
ajst-19178	80	18	cells	cell	NOUN
ajst-19178	80	19	[	[	X
ajst-19178	80	20	38	38	NUM
ajst-19178	80	21	]	]	PUNCT
ajst-19178	80	22	.	.	PUNCT
ajst-19178	81	1	bortezomib	bortezomib	PROPN
ajst-19178	81	2	is	be	AUX
ajst-19178	81	3	a	a	DET
ajst-19178	81	4	proteasome	proteasome	NOUN
ajst-19178	81	5	inhibitor	inhibitor	NOUN
ajst-19178	81	6	,	,	PUNCT
ajst-19178	81	7	which	which	PRON
ajst-19178	81	8	is	be	AUX
ajst-19178	81	9	mainly	mainly	ADV
ajst-19178	81	10	used	use	VERB
ajst-19178	81	11	in	in	ADP
ajst-19178	81	12	the	the	DET
ajst-19178	81	13	treatment	treatment	NOUN
ajst-19178	81	14	of	of	ADP
ajst-19178	81	15	hematological	hematological	ADJ
ajst-19178	81	16	malignancies	malignancy	NOUN
ajst-19178	81	17	such	such	ADJ
ajst-19178	81	18	as	as	ADP
ajst-19178	81	19	multiple	multiple	ADJ
ajst-19178	81	20	myeloma	myeloma	NOUN
ajst-19178	81	21	and	and	CCONJ
ajst-19178	81	22	lymphoma	lymphoma	NOUN
ajst-19178	81	23	.	.	PUNCT
ajst-19178	82	1	hu	hu	PROPN
ajst-19178	82	2	et	et	PROPN
ajst-19178	82	3	al	al	PROPN
ajst-19178	82	4	.	.	PUNCT
ajst-19178	83	1	[	[	X
ajst-19178	83	2	39	39	NUM
ajst-19178	83	3	]	]	PUNCT
ajst-19178	83	4	showed	show	VERB
ajst-19178	83	5	that	that	SCONJ
ajst-19178	83	6	the	the	DET
ajst-19178	83	7	ic50	ic50	PROPN
ajst-19178	83	8	of	of	ADP
ajst-19178	83	9	art	art	NOUN
ajst-19178	83	10	and	and	CCONJ
ajst-19178	83	11	bortezomib	bortezomib	NOUN
ajst-19178	83	12	acting	act	VERB
ajst-19178	83	13	alone	alone	ADV
ajst-19178	83	14	on	on	ADP
ajst-19178	83	15	mv4	mv4	ADJ
ajst-19178	83	16	-	-	ADJ
ajst-19178	83	17	11	11	NUM
ajst-19178	83	18	cells	cell	NOUN
ajst-19178	83	19	for	for	ADP
ajst-19178	83	20	48h	48h	NOUN
ajst-19178	83	21	was	be	AUX
ajst-19178	83	22	1.44	1.44	NUM
ajst-19178	83	23	μg	μg	NOUN
ajst-19178	83	24	/	/	SYM
ajst-19178	83	25	ml	ml	PROPN
ajst-19178	83	26	and	and	CCONJ
ajst-19178	83	27	8.97	8.97	NUM
ajst-19178	83	28	nmol	nmol	NOUN
ajst-19178	83	29	/	/	SYM
ajst-19178	83	30	l	l	NOUN
ajst-19178	83	31	,	,	PUNCT
ajst-19178	83	32	respectively	respectively	ADV
ajst-19178	83	33	,	,	PUNCT
ajst-19178	83	34	and	and	CCONJ
ajst-19178	83	35	both	both	PRON
ajst-19178	83	36	had	have	VERB
ajst-19178	83	37	significant	significant	ADJ
ajst-19178	83	38	inhibitory	inhibitory	ADJ
ajst-19178	83	39	effects	effect	NOUN
ajst-19178	83	40	on	on	ADP
ajst-19178	83	41	mv4	mv4	ADJ
ajst-19178	83	42	-	-	ADJ
ajst-19178	83	43	11	11	NUM
ajst-19178	83	44	cells	cell	NOUN
ajst-19178	83	45	.	.	PUNCT
ajst-19178	84	1	when	when	SCONJ
ajst-19178	84	2	the	the	DET
ajst-19178	84	3	two	two	NUM
ajst-19178	84	4	methods	method	NOUN
ajst-19178	84	5	were	be	AUX
ajst-19178	84	6	used	use	VERB
ajst-19178	84	7	in	in	ADP
ajst-19178	84	8	combination	combination	NOUN
ajst-19178	84	9	,	,	PUNCT
ajst-19178	84	10	the	the	DET
ajst-19178	84	11	proliferation	proliferation	NOUN
ajst-19178	84	12	inhibition	inhibition	NOUN
ajst-19178	84	13	rate	rate	NOUN
ajst-19178	84	14	of	of	ADP
ajst-19178	84	15	the	the	DET
ajst-19178	84	16	cells	cell	NOUN
ajst-19178	84	17	was	be	AUX
ajst-19178	84	18	higher	high	ADJ
ajst-19178	84	19	than	than	ADP
ajst-19178	84	20	that	that	PRON
ajst-19178	84	21	of	of	ADP
ajst-19178	84	22	the	the	DET
ajst-19178	84	23	method	method	NOUN
ajst-19178	84	24	of	of	ADP
ajst-19178	84	25	drug	drug	NOUN
ajst-19178	84	26	alone	alone	ADV
ajst-19178	84	27	.	.	PUNCT
ajst-19178	85	1	the	the	DET
ajst-19178	85	2	combination	combination	NOUN
ajst-19178	85	3	of	of	ADP
ajst-19178	85	4	the	the	DET
ajst-19178	85	5	two	two	NUM
ajst-19178	85	6	drugs	drug	NOUN
ajst-19178	85	7	also	also	ADV
ajst-19178	85	8	significantly	significantly	ADV
ajst-19178	85	9	increased	increase	VERB
ajst-19178	85	10	the	the	DET
ajst-19178	85	11	apoptosis	apoptosis	NOUN
ajst-19178	85	12	rate	rate	NOUN
ajst-19178	85	13	of	of	ADP
ajst-19178	85	14	the	the	DET
ajst-19178	85	15	cells	cell	NOUN
ajst-19178	85	16	,	,	PUNCT
ajst-19178	85	17	and	and	CCONJ
ajst-19178	85	18	the	the	DET
ajst-19178	85	19	mechanism	mechanism	NOUN
ajst-19178	85	20	was	be	AUX
ajst-19178	85	21	that	that	SCONJ
ajst-19178	85	22	the	the	DET
ajst-19178	85	23	two	two	NUM
ajst-19178	85	24	drugs	drug	NOUN
ajst-19178	85	25	up	up	ADV
ajst-19178	85	26	-	-	PUNCT
ajst-19178	85	27	regulated	regulate	VERB
ajst-19178	85	28	the	the	DET
ajst-19178	85	29	expression	expression	NOUN
ajst-19178	85	30	of	of	ADP
ajst-19178	85	31	cleaved	cleaved	ADJ
ajst-19178	85	32	caspase-3	caspase-3	PROPN
ajst-19178	85	33	,	,	PUNCT
ajst-19178	85	34	bim	bim	NOUN
ajst-19178	85	35	,	,	PUNCT
ajst-19178	85	36	and	and	CCONJ
ajst-19178	85	37	lc3b	lc3b	NOUN
ajst-19178	85	38	,	,	PUNCT
ajst-19178	85	39	and	and	CCONJ
ajst-19178	85	40	down	down	ADV
ajst-19178	85	41	-	-	PUNCT
ajst-19178	85	42	regulated	regulate	VERB
ajst-19178	85	43	the	the	DET
ajst-19178	85	44	expression	expression	NOUN
ajst-19178	85	45	of	of	ADP
ajst-19178	85	46	bcl-2	bcl-2	NOUN
ajst-19178	85	47	.	.	PUNCT
ajst-19178	86	1	the	the	DET
ajst-19178	86	2	combination	combination	NOUN
ajst-19178	86	3	of	of	ADP
ajst-19178	86	4	the	the	DET
ajst-19178	86	5	two	two	NUM
ajst-19178	86	6	drugs	drug	NOUN
ajst-19178	86	7	can	can	AUX
ajst-19178	86	8	synergistically	synergistically	ADV
ajst-19178	86	9	inhibit	inhibit	VERB
ajst-19178	86	10	proliferation	proliferation	NOUN
ajst-19178	86	11	and	and	CCONJ
ajst-19178	86	12	promote	promote	VERB
ajst-19178	86	13	apoptosis	apoptosis	NOUN
ajst-19178	86	14	.	.	PUNCT
ajst-19178	87	1	3.3	3.3	NUM
ajst-19178	87	2	.	.	PUNCT
ajst-19178	88	1	synergistic	synergistic	ADJ
ajst-19178	88	2	interaction	interaction	NOUN
ajst-19178	88	3	the	the	DET
ajst-19178	88	4	combination	combination	NOUN
ajst-19178	88	5	of	of	ADP
ajst-19178	88	6	art	art	NOUN
ajst-19178	88	7	,	,	PUNCT
ajst-19178	88	8	venettok	venettok	NOUN
ajst-19178	88	9	and	and	CCONJ
ajst-19178	88	10	cytarabine	cytarabine	NOUN
ajst-19178	88	11	was	be	AUX
ajst-19178	88	12	used	use	VERB
ajst-19178	88	13	in	in	ADP
ajst-19178	88	14	the	the	DET
ajst-19178	88	15	treatment	treatment	NOUN
ajst-19178	88	16	of	of	ADP
ajst-19178	88	17	acute	acute	ADJ
ajst-19178	88	18	myeloid	myeloid	ADJ
ajst-19178	88	19	leukemia	leukemia	NOUN
ajst-19178	88	20	.	.	PUNCT
ajst-19178	89	1	while	while	SCONJ
ajst-19178	89	2	inducing	induce	VERB
ajst-19178	89	3	apoptosis	apoptosis	NOUN
ajst-19178	89	4	,	,	PUNCT
ajst-19178	89	5	vinettok	vinettok	NOUN
ajst-19178	89	6	combined	combine	VERB
ajst-19178	89	7	with	with	ADP
ajst-19178	89	8	cytarabine	cytarabine	NOUN
ajst-19178	89	9	increased	increase	VERB
ajst-19178	89	10	the	the	DET
ajst-19178	89	11	binding	binding	NOUN
ajst-19178	89	12	of	of	ADP
ajst-19178	89	13	mcl-1	mcl-1	NUM
ajst-19178	89	14	and	and	CCONJ
ajst-19178	89	15	bim	bim	NOUN
ajst-19178	89	16	,	,	PUNCT
ajst-19178	89	17	inhibiting	inhibit	VERB
ajst-19178	89	18	part	part	NOUN
ajst-19178	89	19	of	of	ADP
ajst-19178	89	20	apoptosis	apoptosis	NOUN
ajst-19178	89	21	.	.	PUNCT
ajst-19178	90	1	however	however	ADV
ajst-19178	90	2	,	,	PUNCT
ajst-19178	90	3	art	art	NOUN
ajst-19178	90	4	can	can	AUX
ajst-19178	90	5	up	up	ADV
ajst-19178	90	6	-	-	PUNCT
ajst-19178	90	7	regulate	regulate	VERB
ajst-19178	90	8	noxa	noxa	NOUN
ajst-19178	90	9	and	and	CCONJ
ajst-19178	90	10	replace	replace	VERB
ajst-19178	90	11	bim	bim	NOUN
ajst-19178	90	12	bound	bind	VERB
ajst-19178	90	13	to	to	ADP
ajst-19178	90	14	mcl-1	mcl-1	NUM
ajst-19178	90	15	,	,	PUNCT
ajst-19178	90	16	causing	cause	VERB
ajst-19178	90	17	bim	bim	NOUN
ajst-19178	90	18	to	to	PART
ajst-19178	90	19	dissociate	dissociate	VERB
ajst-19178	90	20	and	and	CCONJ
ajst-19178	90	21	recruit	recruit	VERB
ajst-19178	90	22	e3	e3	NOUN
ajst-19178	90	23	ubiquitin	ubiquitin	NOUN
ajst-19178	90	24	ligase	ligase	NOUN
ajst-19178	90	25	to	to	PART
ajst-19178	90	26	degrade	degrade	VERB
ajst-19178	90	27	mcl-1	mcl-1	NOUN
ajst-19178	90	28	,	,	PUNCT
ajst-19178	90	29	reversing	reverse	VERB
ajst-19178	90	30	the	the	DET
ajst-19178	90	31	drug	drug	NOUN
ajst-19178	90	32	resistance	resistance	NOUN
ajst-19178	90	33	of	of	ADP
ajst-19178	90	34	mcl1	mcl1	PROPN
ajst-19178	90	35	/	/	SYM
ajst-19178	90	36	p	p	NOUN
ajst-19178	90	37	-	-	PUNCT
ajst-19178	90	38	chk1	chk1	NOUN
ajst-19178	90	39	treated	treat	VERB
ajst-19178	90	40	by	by	ADP
ajst-19178	90	41	cytarabine	cytarabine	NOUN
ajst-19178	90	42	and	and	CCONJ
ajst-19178	90	43	vinettok	vinettok	NOUN
ajst-19178	90	44	[	[	X
ajst-19178	90	45	31	31	NUM
ajst-19178	90	46	]	]	PUNCT
ajst-19178	90	47	.	.	PUNCT
ajst-19178	91	1	li	li	PROPN
ajst-19178	91	2	et	et	PROPN
ajst-19178	91	3	al	al	PROPN
ajst-19178	91	4	.	.	PUNCT
ajst-19178	92	1	[	[	X
ajst-19178	92	2	40	40	NUM
ajst-19178	92	3	]	]	PUNCT
ajst-19178	92	4	showed	show	VERB
ajst-19178	92	5	that	that	SCONJ
ajst-19178	92	6	the	the	DET
ajst-19178	92	7	ic50	ic50	PROPN
ajst-19178	92	8	values	value	NOUN
ajst-19178	92	9	of	of	ADP
ajst-19178	92	10	solafenib	solafenib	NOUN
ajst-19178	92	11	acting	act	VERB
ajst-19178	92	12	alone	alone	ADV
ajst-19178	92	13	on	on	ADP
ajst-19178	92	14	hepg2	hepg2	NOUN
ajst-19178	92	15	and	and	CCONJ
ajst-19178	92	16	huh7	huh7	NOUN
ajst-19178	92	17	cells	cell	NOUN
ajst-19178	92	18	were	be	AUX
ajst-19178	92	19	5.93	5.93	NUM
ajst-19178	92	20	-	-	PUNCT
ajst-19178	92	21	8.51μm	8.51μm	NUM
ajst-19178	92	22	and	and	CCONJ
ajst-19178	92	23	7.11	7.11	NUM
ajst-19178	92	24	-	-	SYM
ajst-19178	92	25	17.11μm	17.11μm	NUM
ajst-19178	92	26	,	,	PUNCT
ajst-19178	92	27	respectively	respectively	ADV
ajst-19178	92	28	.	.	PUNCT
ajst-19178	93	1	the	the	DET
ajst-19178	93	2	ic50	ic50	PROPN
ajst-19178	93	3	values	value	NOUN
ajst-19178	93	4	of	of	ADP
ajst-19178	93	5	hepg2	hepg2	NOUN
ajst-19178	93	6	and	and	CCONJ
ajst-19178	93	7	huh7	huh7	NOUN
ajst-19178	93	8	cells	cell	NOUN
ajst-19178	93	9	treated	treat	VERB
ajst-19178	93	10	by	by	ADP
ajst-19178	93	11	art	art	NOUN
ajst-19178	93	12	alone	alone	ADV
ajst-19178	93	13	were	be	AUX
ajst-19178	93	14	63.28	63.28	NUM
ajst-19178	93	15	-	-	SYM
ajst-19178	93	16	99.85	99.85	NUM
ajst-19178	93	17	μm	μm	NOUN
ajst-19178	93	18	and	and	CCONJ
ajst-19178	93	19	344.70	344.70	NUM
ajst-19178	93	20	-	-	SYM
ajst-19178	93	21	1,099	1,099	NUM
ajst-19178	93	22	μm	μm	NOUN
ajst-19178	93	23	,	,	PUNCT
ajst-19178	93	24	respectively	respectively	ADV
ajst-19178	93	25	.	.	PUNCT
ajst-19178	94	1	the	the	DET
ajst-19178	94	2	sensitivity	sensitivity	NOUN
ajst-19178	94	3	of	of	ADP
ajst-19178	94	4	these	these	DET
ajst-19178	94	5	cells	cell	NOUN
ajst-19178	94	6	to	to	ADP
ajst-19178	94	7	art	art	NOUN
ajst-19178	94	8	treatment	treatment	NOUN
ajst-19178	94	9	was	be	AUX
ajst-19178	94	10	low	low	ADJ
ajst-19178	94	11	.	.	PUNCT
ajst-19178	95	1	when	when	SCONJ
ajst-19178	95	2	the	the	DET
ajst-19178	95	3	two	two	NUM
ajst-19178	95	4	drugs	drug	NOUN
ajst-19178	95	5	treated	treat	VERB
ajst-19178	95	6	the	the	DET
ajst-19178	95	7	cell	cell	NOUN
ajst-19178	95	8	line	line	NOUN
ajst-19178	95	9	at	at	ADP
ajst-19178	95	10	a	a	DET
ajst-19178	95	11	constant	constant	ADJ
ajst-19178	95	12	ratio	ratio	NOUN
ajst-19178	95	13	(	(	PUNCT
ajst-19178	95	14	1:10	1:10	NUM
ajst-19178	95	15	for	for	ADP
ajst-19178	95	16	hepg2	hepg2	NOUN
ajst-19178	95	17	and	and	CCONJ
ajst-19178	95	18	1:50	1:50	NUM
ajst-19178	95	19	for	for	ADP
ajst-19178	95	20	huh7	huh7	PROPN
ajst-19178	95	21	)	)	PUNCT
ajst-19178	95	22	,	,	PUNCT
ajst-19178	95	23	the	the	DET
ajst-19178	95	24	combination	combination	NOUN
ajst-19178	95	25	significantly	significantly	ADV
ajst-19178	95	26	inhibited	inhibit	VERB
ajst-19178	95	27	the	the	DET
ajst-19178	95	28	growth	growth	NOUN
ajst-19178	95	29	of	of	ADP
ajst-19178	95	30	tumor	tumor	NOUN
ajst-19178	95	31	cells	cell	NOUN
ajst-19178	95	32	without	without	ADP
ajst-19178	95	33	significantly	significantly	ADV
ajst-19178	95	34	enhanced	enhance	VERB
ajst-19178	95	35	hepatotoxicity	hepatotoxicity	NOUN
ajst-19178	95	36	compared	compare	VERB
ajst-19178	95	37	with	with	ADP
ajst-19178	95	38	the	the	DET
ajst-19178	95	39	single	single	ADJ
ajst-19178	95	40	drug	drug	NOUN
ajst-19178	95	41	.	.	PUNCT
ajst-19178	96	1	the	the	DET
ajst-19178	96	2	combined	combined	ADJ
ajst-19178	96	3	use	use	NOUN
ajst-19178	96	4	of	of	ADP
ajst-19178	96	5	the	the	DET
ajst-19178	96	6	two	two	NUM
ajst-19178	96	7	can	can	AUX
ajst-19178	96	8	significantly	significantly	ADV
ajst-19178	96	9	reduce	reduce	VERB
ajst-19178	96	10	the	the	DET
ajst-19178	96	11	expression	expression	NOUN
ajst-19178	96	12	of	of	ADP
ajst-19178	96	13	vegfr2	vegfr2	ADJ
ajst-19178	96	14	protein	protein	NOUN
ajst-19178	96	15	,	,	PUNCT
ajst-19178	96	16	synergistically	synergistically	ADV
ajst-19178	96	17	play	play	VERB
ajst-19178	96	18	an	an	DET
ajst-19178	96	19	anti	anti	ADJ
ajst-19178	96	20	-	-	ADJ
ajst-19178	96	21	angiogenic	angiogenic	ADJ
ajst-19178	96	22	role	role	NOUN
ajst-19178	96	23	,	,	PUNCT
ajst-19178	96	24	and	and	CCONJ
ajst-19178	96	25	enhance	enhance	VERB
ajst-19178	96	26	the	the	DET
ajst-19178	96	27	apoptosis	apoptosis	NOUN
ajst-19178	96	28	of	of	ADP
ajst-19178	96	29	tumor	tumor	NOUN
ajst-19178	96	30	cells	cell	NOUN
ajst-19178	96	31	.	.	PUNCT
ajst-19178	97	1	art	art	NOUN
ajst-19178	97	2	has	have	VERB
ajst-19178	97	3	heme	heme	NOUN
ajst-19178	97	4	-	-	PUNCT
ajst-19178	97	5	dependent	dependent	ADJ
ajst-19178	97	6	anti	anti	ADJ
ajst-19178	97	7	-	-	ADJ
ajst-19178	97	8	tumor	tumor	ADJ
ajst-19178	97	9	activity	activity	NOUN
ajst-19178	97	10	,	,	PUNCT
ajst-19178	97	11	and	and	CCONJ
ajst-19178	97	12	histone	histone	NOUN
ajst-19178	97	13	deacetylase	deacetylase	VERB
ajst-19178	97	14	inhibitors	inhibitor	NOUN
ajst-19178	97	15	(	(	PUNCT
ajst-19178	97	16	hdaci	hdaci	NOUN
ajst-19178	97	17	)	)	PUNCT
ajst-19178	97	18	can	can	AUX
ajst-19178	97	19	promote	promote	VERB
ajst-19178	97	20	heme	heme	ADJ
ajst-19178	97	21	synthesis	synthesis	NOUN
ajst-19178	97	22	in	in	ADP
ajst-19178	97	23	red	red	ADJ
ajst-19178	97	24	blood	blood	NOUN
ajst-19178	97	25	cells	cell	NOUN
ajst-19178	97	26	,	,	PUNCT
ajst-19178	97	27	and	and	CCONJ
ajst-19178	97	28	the	the	DET
ajst-19178	97	29	combination	combination	NOUN
ajst-19178	97	30	of	of	ADP
ajst-19178	97	31	the	the	DET
ajst-19178	97	32	two	two	NUM
ajst-19178	97	33	has	have	VERB
ajst-19178	97	34	a	a	DET
ajst-19178	97	35	synergistic	synergistic	ADJ
ajst-19178	97	36	anti	anti	ADJ
ajst-19178	97	37	-	-	ADJ
ajst-19178	97	38	tumor	tumor	ADJ
ajst-19178	97	39	effect	effect	NOUN
ajst-19178	97	40	.	.	PUNCT
ajst-19178	98	1	the	the	DET
ajst-19178	98	2	combination	combination	NOUN
ajst-19178	98	3	of	of	ADP
ajst-19178	98	4	drugs	drug	NOUN
ajst-19178	98	5	can	can	AUX
ajst-19178	98	6	effectively	effectively	ADV
ajst-19178	98	7	reduce	reduce	VERB
ajst-19178	98	8	the	the	DET
ajst-19178	98	9	activity	activity	NOUN
ajst-19178	98	10	of	of	ADP
ajst-19178	98	11	huh-7	huh-7	NOUN
ajst-19178	98	12	,	,	PUNCT
ajst-19178	98	13	hep3b	hep3b	PROPN
ajst-19178	98	14	,	,	PUNCT
ajst-19178	98	15	hct116	hct116	PROPN
ajst-19178	98	16	,	,	PUNCT
ajst-19178	98	17	a549	a549	PROPN
ajst-19178	98	18	and	and	CCONJ
ajst-19178	98	19	panc-1	panc-1	NOUN
ajst-19178	98	20	cells	cell	NOUN
ajst-19178	98	21	.	.	PUNCT
ajst-19178	99	1	art	art	NOUN
ajst-19178	99	2	consumes	consume	NOUN
ajst-19178	99	3	free	free	ADJ
ajst-19178	99	4	heme	heme	NOUN
ajst-19178	99	5	,	,	PUNCT
ajst-19178	99	6	weakens	weaken	VERB
ajst-19178	99	7	the	the	DET
ajst-19178	99	8	negative	negative	ADJ
ajst-19178	99	9	feedback	feedback	NOUN
ajst-19178	99	10	inhibition	inhibition	NOUN
ajst-19178	99	11	of	of	ADP
ajst-19178	99	12	alas1	alas1	NOUN
ajst-19178	99	13	,	,	PUNCT
ajst-19178	99	14	promotes	promote	VERB
ajst-19178	99	15	the	the	DET
ajst-19178	99	16	expression	expression	NOUN
ajst-19178	99	17	of	of	ADP
ajst-19178	99	18	alas1	alas1	NOUN
ajst-19178	99	19	protein	protein	NOUN
ajst-19178	99	20	,	,	PUNCT
ajst-19178	99	21	and	and	CCONJ
ajst-19178	99	22	enhances	enhance	VERB
ajst-19178	99	23	the	the	DET
ajst-19178	99	24	sensitivity	sensitivity	NOUN
ajst-19178	99	25	of	of	ADP
ajst-19178	99	26	tumor	tumor	NOUN
ajst-19178	99	27	cells	cell	NOUN
ajst-19178	99	28	to	to	ADP
ajst-19178	99	29	art	art	NOUN
ajst-19178	99	30	[	[	X
ajst-19178	99	31	41	41	NUM
ajst-19178	99	32	]	]	PUNCT
ajst-19178	99	33	.	.	PUNCT
ajst-19178	100	1	wu	wu	PROPN
ajst-19178	100	2	et	et	PROPN
ajst-19178	100	3	al	al	PROPN
ajst-19178	100	4	.	.	PUNCT
ajst-19178	101	1	[	[	X
ajst-19178	101	2	42	42	NUM
ajst-19178	101	3	]	]	PUNCT
ajst-19178	101	4	showed	show	VERB
ajst-19178	101	5	that	that	SCONJ
ajst-19178	101	6	art	art	NOUN
ajst-19178	101	7	could	could	AUX
ajst-19178	101	8	promote	promote	VERB
ajst-19178	101	9	the	the	DET
ajst-19178	101	10	sensitivity	sensitivity	NOUN
ajst-19178	101	11	of	of	ADP
ajst-19178	101	12	liver	liver	NOUN
ajst-19178	101	13	cancer	cancer	NOUN
ajst-19178	101	14	cells	cell	NOUN
ajst-19178	101	15	to	to	AUX
ajst-19178	101	16	sorafenib	sorafenib	PROPN
ajst-19178	101	17	.	.	PUNCT
ajst-19178	102	1	the	the	DET
ajst-19178	102	2	combination	combination	NOUN
ajst-19178	102	3	of	of	ADP
ajst-19178	102	4	art	art	NOUN
ajst-19178	102	5	and	and	CCONJ
ajst-19178	102	6	sorafenib	sorafenib	NOUN
ajst-19178	102	7	can	can	AUX
ajst-19178	102	8	inhibit	inhibit	VERB
ajst-19178	102	9	tumor	tumor	NOUN
ajst-19178	102	10	growth	growth	NOUN
ajst-19178	102	11	,	,	PUNCT
ajst-19178	102	12	and	and	CCONJ
ajst-19178	102	13	sorafenib	sorafenib	NOUN
ajst-19178	102	14	can	can	AUX
ajst-19178	102	15	reduce	reduce	VERB
ajst-19178	102	16	the	the	DET
ajst-19178	102	17	expression	expression	NOUN
ajst-19178	102	18	of	of	ADP
ajst-19178	102	19	p	p	NOUN
ajst-19178	102	20	-	-	PUNCT
ajst-19178	102	21	raf1	raf1	ADJ
ajst-19178	102	22	and	and	CCONJ
ajst-19178	102	23	p	p	PROPN
ajst-19178	102	24	-	-	PUNCT
ajst-19178	102	25	erk1/2	erk1/2	PROPN
ajst-19178	102	26	in	in	ADP
ajst-19178	102	27	raf	raf	PROPN
ajst-19178	102	28	/	/	SYM
ajst-19178	102	29	mapk	mapk	NOUN
ajst-19178	102	30	pathway	pathway	NOUN
ajst-19178	102	31	,	,	PUNCT
ajst-19178	102	32	but	but	CCONJ
ajst-19178	102	33	has	have	VERB
ajst-19178	102	34	no	no	DET
ajst-19178	102	35	effect	effect	NOUN
ajst-19178	102	36	on	on	ADP
ajst-19178	102	37	pi3k	pi3k	PROPN
ajst-19178	102	38	/	/	SYM
ajst-19178	102	39	akt	akt	PROPN
ajst-19178	102	40	/	/	SYM
ajst-19178	102	41	mtor	mtor	PROPN
ajst-19178	102	42	pathway	pathway	NOUN
ajst-19178	102	43	.	.	PUNCT
ajst-19178	103	1	however	however	ADV
ajst-19178	103	2	,	,	PUNCT
ajst-19178	103	3	art	art	NOUN
ajst-19178	103	4	can	can	AUX
ajst-19178	103	5	inhibit	inhibit	VERB
ajst-19178	103	6	the	the	DET
ajst-19178	103	7	expression	expression	NOUN
ajst-19178	103	8	of	of	ADP
ajst-19178	103	9	p	p	PROPN
ajst-19178	103	10	-	-	PUNCT
ajst-19178	103	11	akt	akt	NOUN
ajst-19178	103	12	and	and	CCONJ
ajst-19178	103	13	p	p	NOUN
ajst-19178	103	14	-	-	PUNCT
ajst-19178	103	15	mtor	mtor	NOUN
ajst-19178	103	16	in	in	ADP
ajst-19178	103	17	pi3k	pi3k	PROPN
ajst-19178	103	18	/	/	SYM
ajst-19178	103	19	akt	akt	PROPN
ajst-19178	103	20	/	/	SYM
ajst-19178	103	21	mtor	mtor	PROPN
ajst-19178	103	22	pathway	pathway	NOUN
ajst-19178	103	23	,	,	PUNCT
ajst-19178	103	24	but	but	CCONJ
ajst-19178	103	25	has	have	VERB
ajst-19178	103	26	no	no	DET
ajst-19178	103	27	inhibitory	inhibitory	ADJ
ajst-19178	103	28	effect	effect	NOUN
ajst-19178	103	29	on	on	ADP
ajst-19178	103	30	raf	raf	PROPN
ajst-19178	103	31	/	/	SYM
ajst-19178	103	32	mapk	mapk	NOUN
ajst-19178	103	33	pathway	pathway	NOUN
ajst-19178	103	34	.	.	PUNCT
ajst-19178	104	1	the	the	DET
ajst-19178	104	2	combination	combination	NOUN
ajst-19178	104	3	of	of	ADP
ajst-19178	104	4	art	art	NOUN
ajst-19178	104	5	and	and	CCONJ
ajst-19178	104	6	art	art	NOUN
ajst-19178	104	7	can	can	AUX
ajst-19178	104	8	significantly	significantly	ADV
ajst-19178	104	9	reduce	reduce	VERB
ajst-19178	104	10	the	the	DET
ajst-19178	104	11	expression	expression	NOUN
ajst-19178	104	12	of	of	ADP
ajst-19178	104	13	pmtor	pmtor	NOUN
ajst-19178	104	14	and	and	CCONJ
ajst-19178	104	15	p	p	NOUN
ajst-19178	104	16	-	-	PUNCT
ajst-19178	104	17	erk	erk	NOUN
ajst-19178	104	18	and	and	CCONJ
ajst-19178	104	19	promote	promote	VERB
ajst-19178	104	20	the	the	DET
ajst-19178	104	21	expression	expression	NOUN
ajst-19178	104	22	of	of	ADP
ajst-19178	104	23	c	c	NOUN
ajst-19178	104	24	-	-	PUNCT
ajst-19178	104	25	parp	parp	NOUN
ajst-19178	104	26	and	and	CCONJ
ajst-19178	104	27	p	p	NOUN
ajst-19178	104	28	-	-	PUNCT
ajst-19178	104	29	parp	parp	NOUN
ajst-19178	104	30	,	,	PUNCT
ajst-19178	104	31	thus	thus	ADV
ajst-19178	104	32	promoting	promote	VERB
ajst-19178	104	33	the	the	DET
ajst-19178	104	34	apoptosis	apoptosis	NOUN
ajst-19178	104	35	of	of	ADP
ajst-19178	104	36	liver	liver	NOUN
ajst-19178	104	37	cancer	cancer	NOUN
ajst-19178	104	38	cells	cell	NOUN
ajst-19178	104	39	.	.	PUNCT
ajst-19178	105	1	3.4	3.4	NUM
ajst-19178	105	2	.	.	PUNCT
ajst-19178	105	3	others	other	NOUN
ajst-19178	105	4	both	both	CCONJ
ajst-19178	105	5	oxaliplatin	oxaliplatin	NOUN
ajst-19178	105	6	and	and	CCONJ
ajst-19178	105	7	art	art	NOUN
ajst-19178	105	8	have	have	VERB
ajst-19178	105	9	certain	certain	ADJ
ajst-19178	105	10	inhibitory	inhibitory	ADJ
ajst-19178	105	11	effects	effect	NOUN
ajst-19178	105	12	on	on	ADP
ajst-19178	105	13	tumor	tumor	NOUN
ajst-19178	105	14	.	.	PUNCT
ajst-19178	106	1	studies	study	NOUN
ajst-19178	106	2	have	have	AUX
ajst-19178	106	3	shown	show	VERB
ajst-19178	106	4	that	that	SCONJ
ajst-19178	106	5	their	their	PRON
ajst-19178	106	6	complex	complex	ADJ
ajst-19178	106	7	opa	opa	NOUN
ajst-19178	106	8	can	can	AUX
ajst-19178	106	9	directly	directly	ADV
ajst-19178	106	10	inhibit	inhibit	VERB
ajst-19178	106	11	the	the	DET
ajst-19178	106	12	proliferation	proliferation	NOUN
ajst-19178	106	13	of	of	ADP
ajst-19178	106	14	human	human	ADJ
ajst-19178	106	15	colon	colon	NOUN
ajst-19178	106	16	cancer	cancer	NOUN
ajst-19178	106	17	cells	cell	NOUN
ajst-19178	106	18	and	and	CCONJ
ajst-19178	106	19	inhibit	inhibit	VERB
ajst-19178	106	20	the	the	DET
ajst-19178	106	21	immunomodulatory	immunomodulatory	ADJ
ajst-19178	106	22	activity	activity	NOUN
ajst-19178	106	23	of	of	ADP
ajst-19178	106	24	macrophage	macrophage	ADJ
ajst-19178	106	25	trem2	trem2	NOUN
ajst-19178	106	26	in	in	ADP
ajst-19178	106	27	vivo	vivo	NOUN
ajst-19178	106	28	.	.	PUNCT
ajst-19178	107	1	opa	opa	NOUN
ajst-19178	107	2	prevents	prevent	VERB
ajst-19178	107	3	tumor	tumor	NOUN
ajst-19178	107	4	growth	growth	NOUN
ajst-19178	107	5	in	in	ADP
ajst-19178	107	6	vivo	vivo	NOUN
ajst-19178	107	7	by	by	ADP
ajst-19178	107	8	reducing	reduce	VERB
ajst-19178	107	9	the	the	DET
ajst-19178	107	10	number	number	NOUN
ajst-19178	107	11	of	of	ADP
ajst-19178	107	12	cd206	cd206	PROPN
ajst-19178	107	13	and	and	CCONJ
ajst-19178	107	14	cx+3	cx+3	NUM
ajst-19178	107	15	cr1	cr1	X
ajst-19178	107	16	immunosuppressive	immunosuppressive	ADJ
ajst-19178	107	17	macrophages	macrophage	NOUN
ajst-19178	107	18	;	;	PUNCT
ajst-19178	107	19	it	it	PRON
ajst-19178	107	20	also	also	ADV
ajst-19178	107	21	promotes	promote	VERB
ajst-19178	107	22	the	the	DET
ajst-19178	107	23	increase	increase	NOUN
ajst-19178	107	24	and	and	CCONJ
ajst-19178	107	25	infiltration	infiltration	NOUN
ajst-19178	107	26	of	of	ADP
ajst-19178	107	27	immunostimulated	immunostimulate	VERB
ajst-19178	107	28	dendritic	dendritic	ADJ
ajst-19178	107	29	cells	cell	NOUN
ajst-19178	107	30	,	,	PUNCT
ajst-19178	107	31	cytotoxic	cytotoxic	ADJ
ajst-19178	107	32	t	t	NOUN
ajst-19178	107	33	cells	cell	NOUN
ajst-19178	107	34	,	,	PUNCT
ajst-19178	107	35	and	and	CCONJ
ajst-19178	107	36	natural	natural	ADJ
ajst-19178	107	37	killer	killer	NOUN
ajst-19178	107	38	cells	cell	NOUN
ajst-19178	107	39	,	,	PUNCT
ajst-19178	107	40	and	and	CCONJ
ajst-19178	107	41	inhibits	inhibit	VERB
ajst-19178	107	42	tumors	tumor	NOUN
ajst-19178	107	43	by	by	ADP
ajst-19178	107	44	shaping	shape	VERB
ajst-19178	107	45	the	the	DET
ajst-19178	107	46	immunosuppressive	immunosuppressive	ADJ
ajst-19178	107	47	microenvironment	microenvironment	NOUN
ajst-19178	107	48	[	[	X
ajst-19178	107	49	43	43	NUM
ajst-19178	107	50	]	]	PUNCT
ajst-19178	107	51	.	.	PUNCT
ajst-19178	108	1	4	4	X
ajst-19178	108	2	.	.	X
ajst-19178	108	3	summary	summary	NOUN
ajst-19178	108	4	and	and	CCONJ
ajst-19178	108	5	prospect	prospect	NOUN
ajst-19178	108	6	cancer	cancer	NOUN
ajst-19178	108	7	has	have	AUX
ajst-19178	108	8	become	become	VERB
ajst-19178	108	9	the	the	DET
ajst-19178	108	10	most	most	ADV
ajst-19178	108	11	important	important	ADJ
ajst-19178	108	12	disease	disease	NOUN
ajst-19178	108	13	burden	burden	NOUN
ajst-19178	108	14	in	in	ADP
ajst-19178	108	15	the	the	DET
ajst-19178	108	16	world	world	NOUN
ajst-19178	108	17	.	.	PUNCT
ajst-19178	109	1	currently	currently	ADV
ajst-19178	109	2	,	,	PUNCT
ajst-19178	109	3	drug	drug	NOUN
ajst-19178	109	4	therapy	therapy	NOUN
ajst-19178	109	5	is	be	AUX
ajst-19178	109	6	the	the	DET
ajst-19178	109	7	main	main	ADJ
ajst-19178	109	8	treatment	treatment	NOUN
ajst-19178	109	9	for	for	ADP
ajst-19178	109	10	cancer	cancer	NOUN
ajst-19178	109	11	,	,	PUNCT
ajst-19178	109	12	but	but	CCONJ
ajst-19178	109	13	the	the	DET
ajst-19178	109	14	single	single	ADJ
ajst-19178	109	15	use	use	NOUN
ajst-19178	109	16	of	of	ADP
ajst-19178	109	17	chemotherapy	chemotherapy	NOUN
ajst-19178	109	18	drugs	drug	NOUN
ajst-19178	109	19	has	have	VERB
ajst-19178	109	20	great	great	ADJ
ajst-19178	109	21	harm	harm	NOUN
ajst-19178	109	22	to	to	ADP
ajst-19178	109	23	human	human	ADJ
ajst-19178	109	24	body	body	NOUN
ajst-19178	109	25	,	,	PUNCT
ajst-19178	109	26	more	more	ADV
ajst-19178	109	27	adverse	adverse	ADJ
ajst-19178	109	28	reactions	reaction	NOUN
ajst-19178	109	29	and	and	CCONJ
ajst-19178	109	30	easy	easy	ADJ
ajst-19178	109	31	to	to	PART
ajst-19178	109	32	produce	produce	VERB
ajst-19178	109	33	drug	drug	NOUN
ajst-19178	109	34	resistance	resistance	NOUN
ajst-19178	109	35	.	.	PUNCT
ajst-19178	110	1	in	in	ADP
ajst-19178	110	2	recent	recent	ADJ
ajst-19178	110	3	years	year	NOUN
ajst-19178	110	4	,	,	PUNCT
ajst-19178	110	5	drug	drug	NOUN
ajst-19178	110	6	combination	combination	NOUN
ajst-19178	110	7	has	have	AUX
ajst-19178	110	8	become	become	VERB
ajst-19178	110	9	a	a	DET
ajst-19178	110	10	research	research	NOUN
ajst-19178	110	11	hotspot	hotspot	NOUN
ajst-19178	110	12	because	because	SCONJ
ajst-19178	110	13	of	of	ADP
ajst-19178	110	14	its	its	PRON
ajst-19178	110	15	advantages	advantage	NOUN
ajst-19178	110	16	of	of	ADP
ajst-19178	110	17	synergistic	synergistic	ADJ
ajst-19178	110	18	effect	effect	NOUN
ajst-19178	110	19	,	,	PUNCT
ajst-19178	110	20	reducing	reduce	VERB
ajst-19178	110	21	effective	effective	ADJ
ajst-19178	110	22	dose	dose	NOUN
ajst-19178	110	23	and	and	CCONJ
ajst-19178	110	24	adverse	adverse	ADJ
ajst-19178	110	25	reactions	reaction	NOUN
ajst-19178	110	26	.	.	PUNCT
ajst-19178	111	1	art	art	NOUN
ajst-19178	111	2	has	have	VERB
ajst-19178	111	3	anti	anti	ADJ
ajst-19178	111	4	-	-	ADJ
ajst-19178	111	5	tumor	tumor	ADJ
ajst-19178	111	6	activity	activity	NOUN
ajst-19178	111	7	,	,	PUNCT
ajst-19178	111	8	and	and	CCONJ
ajst-19178	111	9	its	its	PRON
ajst-19178	111	10	toxic	toxic	ADJ
ajst-19178	111	11	side	side	NOUN
ajst-19178	111	12	effects	effect	NOUN
ajst-19178	111	13	are	be	AUX
ajst-19178	111	14	small	small	ADJ
ajst-19178	111	15	,	,	PUNCT
ajst-19178	111	16	few	few	ADJ
ajst-19178	111	17	adverse	adverse	ADJ
ajst-19178	111	18	reactions	reaction	NOUN
ajst-19178	111	19	,	,	PUNCT
ajst-19178	111	20	can	can	AUX
ajst-19178	111	21	be	be	AUX
ajst-19178	111	22	used	use	VERB
ajst-19178	111	23	as	as	ADP
ajst-19178	111	24	a	a	DET
ajst-19178	111	25	combination	combination	NOUN
ajst-19178	111	26	of	of	ADP
ajst-19178	111	27	drug	drug	NOUN
ajst-19178	111	28	choice	choice	NOUN
ajst-19178	111	29	.	.	PUNCT
ajst-19178	112	1	many	many	ADJ
ajst-19178	112	2	studies	study	NOUN
ajst-19178	112	3	have	have	AUX
ajst-19178	112	4	shown	show	VERB
ajst-19178	112	5	that	that	SCONJ
ajst-19178	112	6	art	art	NOUN
ajst-19178	112	7	can	can	AUX
ajst-19178	112	8	be	be	AUX
ajst-19178	112	9	used	use	VERB
ajst-19178	112	10	in	in	ADP
ajst-19178	112	11	combination	combination	NOUN
ajst-19178	112	12	with	with	ADP
ajst-19178	112	13	common	common	ADJ
ajst-19178	112	14	anti	anti	ADJ
ajst-19178	112	15	-	-	ADJ
ajst-19178	112	16	tumor	tumor	ADJ
ajst-19178	112	17	drugs	drug	NOUN
ajst-19178	112	18	such	such	ADJ
ajst-19178	112	19	as	as	ADP
ajst-19178	112	20	alkane	alkane	NOUN
ajst-19178	112	21	,	,	PUNCT
ajst-19178	112	22	anti	anti	ADJ
ajst-19178	112	23	-	-	ADJ
ajst-19178	112	24	tumor	tumor	ADJ
ajst-19178	112	25	antibiotics	antibiotic	NOUN
ajst-19178	112	26	,	,	PUNCT
ajst-19178	112	27	and	and	CCONJ
ajst-19178	112	28	antimetabolic	antimetabolic	ADJ
ajst-19178	112	29	drugs	drug	NOUN
ajst-19178	112	30	to	to	PART
ajst-19178	112	31	significantly	significantly	ADV
ajst-19178	112	32	enhance	enhance	VERB
ajst-19178	112	33	their	their	PRON
ajst-19178	112	34	anti	anti	ADJ
ajst-19178	112	35	-	-	ADJ
ajst-19178	112	36	tumor	tumor	ADJ
ajst-19178	112	37	activity	activity	NOUN
ajst-19178	112	38	,	,	PUNCT
ajst-19178	112	39	reverse	reverse	ADJ
ajst-19178	112	40	drug	drug	NOUN
ajst-19178	112	41	resistance	resistance	NOUN
ajst-19178	112	42	,	,	PUNCT
ajst-19178	112	43	reduce	reduce	VERB
ajst-19178	112	44	toxic	toxic	ADJ
ajst-19178	112	45	side	side	NOUN
ajst-19178	112	46	effects	effect	NOUN
ajst-19178	112	47	,	,	PUNCT
ajst-19178	112	48	and	and	CCONJ
ajst-19178	112	49	provide	provide	VERB
ajst-19178	112	50	a	a	DET
ajst-19178	112	51	new	new	ADJ
ajst-19178	112	52	treatment	treatment	NOUN
ajst-19178	112	53	plan	plan	NOUN
ajst-19178	112	54	for	for	ADP
ajst-19178	112	55	tumor	tumor	NOUN
ajst-19178	112	56	patients	patient	NOUN
ajst-19178	112	57	.	.	PUNCT
ajst-19178	113	1	however	however	ADV
ajst-19178	113	2	,	,	PUNCT
ajst-19178	113	3	most	most	ADJ
ajst-19178	113	4	of	of	ADP
ajst-19178	113	5	the	the	DET
ajst-19178	113	6	studies	study	NOUN
ajst-19178	113	7	on	on	ADP
ajst-19178	113	8	art	art	NOUN
ajst-19178	113	9	combined	combine	VERB
ajst-19178	113	10	drug	drug	NOUN
ajst-19178	113	11	use	use	NOUN
ajst-19178	113	12	are	be	AUX
ajst-19178	113	13	in	in	ADP
ajst-19178	113	14	the	the	DET
ajst-19178	113	15	basic	basic	ADJ
ajst-19178	113	16	experimental	experimental	ADJ
ajst-19178	113	17	stage	stage	NOUN
ajst-19178	113	18	,	,	PUNCT
ajst-19178	113	19	and	and	CCONJ
ajst-19178	113	20	the	the	DET
ajst-19178	113	21	clinical	clinical	ADJ
ajst-19178	113	22	studies	study	NOUN
ajst-19178	113	23	are	be	AUX
ajst-19178	113	24	relatively	relatively	ADV
ajst-19178	113	25	few	few	ADJ
ajst-19178	113	26	.	.	PUNCT
ajst-19178	114	1	its	its	PRON
ajst-19178	114	2	safe	safe	ADJ
ajst-19178	114	3	dosage	dosage	NOUN
ajst-19178	114	4	and	and	CCONJ
ajst-19178	114	5	whether	whether	SCONJ
ajst-19178	114	6	it	it	PRON
ajst-19178	114	7	has	have	VERB
ajst-19178	114	8	toxic	toxic	ADJ
ajst-19178	114	9	and	and	CCONJ
ajst-19178	114	10	side	side	NOUN
ajst-19178	114	11	effects	effect	NOUN
ajst-19178	114	12	need	need	VERB
ajst-19178	114	13	to	to	PART
ajst-19178	114	14	be	be	AUX
ajst-19178	114	15	further	far	ADV
ajst-19178	114	16	explored	explore	VERB
ajst-19178	114	17	.	.	PUNCT
ajst-19178	115	1	at	at	ADP
ajst-19178	115	2	the	the	DET
ajst-19178	115	3	same	same	ADJ
ajst-19178	115	4	time	time	NOUN
ajst-19178	115	5	,	,	PUNCT
ajst-19178	115	6	due	due	ADP
ajst-19178	115	7	to	to	ADP
ajst-19178	115	8	the	the	DET
ajst-19178	115	9	complex	complex	ADJ
ajst-19178	115	10	tumorigenesis	tumorigenesis	NOUN
ajst-19178	115	11	mechanism	mechanism	NOUN
ajst-19178	115	12	,	,	PUNCT
ajst-19178	115	13	involving	involve	VERB
ajst-19178	115	14	multiple	multiple	ADJ
ajst-19178	115	15	factors	factor	NOUN
ajst-19178	115	16	and	and	CCONJ
ajst-19178	115	17	signaling	signal	VERB
ajst-19178	115	18	pathways	pathway	NOUN
ajst-19178	115	19	,	,	PUNCT
ajst-19178	115	20	the	the	DET
ajst-19178	115	21	anti	anti	ADJ
ajst-19178	115	22	-	-	ADJ
ajst-19178	115	23	tumor	tumor	ADJ
ajst-19178	115	24	mechanism	mechanism	NOUN
ajst-19178	115	25	of	of	ADP
ajst-19178	115	26	art	art	NOUN
ajst-19178	115	27	has	have	AUX
ajst-19178	115	28	not	not	PART
ajst-19178	115	29	been	be	AUX
ajst-19178	115	30	fully	fully	ADV
ajst-19178	115	31	defined	define	VERB
ajst-19178	115	32	.	.	PUNCT
ajst-19178	116	1	in	in	ADP
ajst-19178	116	2	addition	addition	NOUN
ajst-19178	116	3	,	,	PUNCT
ajst-19178	116	4	due	due	ADP
ajst-19178	116	5	to	to	ADP
ajst-19178	116	6	the	the	DET
ajst-19178	116	7	different	different	ADJ
ajst-19178	116	8	types	type	NOUN
ajst-19178	116	9	of	of	ADP
ajst-19178	116	10	tumors	tumor	NOUN
ajst-19178	116	11	,	,	PUNCT
ajst-19178	116	12	the	the	DET
ajst-19178	116	13	administration	administration	NOUN
ajst-19178	116	14	methods	method	NOUN
ajst-19178	116	15	are	be	AUX
ajst-19178	116	16	also	also	ADV
ajst-19178	116	17	different	different	ADJ
ajst-19178	116	18	,	,	PUNCT
ajst-19178	116	19	and	and	CCONJ
ajst-19178	116	20	whether	whether	SCONJ
ajst-19178	116	21	the	the	DET
ajst-19178	116	22	anti	anti	ADJ
ajst-19178	116	23	-	-	ADJ
ajst-19178	116	24	tumor	tumor	ADJ
ajst-19178	116	25	effects	effect	NOUN
ajst-19178	116	26	of	of	ADP
ajst-19178	116	27	art	art	NOUN
ajst-19178	116	28	under	under	ADP
ajst-19178	116	29	different	different	ADJ
ajst-19178	116	30	administration	administration	NOUN
ajst-19178	116	31	routes	route	NOUN
ajst-19178	116	32	are	be	AUX
ajst-19178	116	33	significantly	significantly	ADV
ajst-19178	116	34	different	different	ADJ
ajst-19178	116	35	.	.	PUNCT
ajst-19178	117	1	therefore	therefore	ADV
ajst-19178	117	2	,	,	PUNCT
ajst-19178	117	3	the	the	DET
ajst-19178	117	4	anti	anti	ADJ
ajst-19178	117	5	-	-	ADJ
ajst-19178	117	6	tumor	tumor	ADJ
ajst-19178	117	7	mechanism	mechanism	NOUN
ajst-19178	117	8	of	of	ADP
ajst-19178	117	9	art	art	NOUN
ajst-19178	117	10	combined	combine	VERB
ajst-19178	117	11	drug	drug	NOUN
ajst-19178	117	12	use	use	NOUN
ajst-19178	117	13	needs	need	NOUN
ajst-19178	117	14	to	to	PART
ajst-19178	117	15	be	be	AUX
ajst-19178	117	16	further	far	ADV
ajst-19178	117	17	studied	study	VERB
ajst-19178	117	18	,	,	PUNCT
ajst-19178	117	19	and	and	CCONJ
ajst-19178	117	20	clinical	clinical	ADJ
ajst-19178	117	21	research	research	NOUN
ajst-19178	117	22	should	should	AUX
ajst-19178	117	23	be	be	AUX
ajst-19178	117	24	strengthened	strengthen	VERB
ajst-19178	117	25	at	at	ADP
ajst-19178	117	26	the	the	DET
ajst-19178	117	27	same	same	ADJ
ajst-19178	117	28	time	time	NOUN
ajst-19178	117	29	to	to	PART
ajst-19178	117	30	lay	lay	VERB
ajst-19178	117	31	a	a	DET
ajst-19178	117	32	foundation	foundation	NOUN
ajst-19178	117	33	for	for	ADP
ajst-19178	117	34	the	the	DET
ajst-19178	117	35	clinical	clinical	ADJ
ajst-19178	117	36	application	application	NOUN
ajst-19178	117	37	of	of	ADP
ajst-19178	117	38	combined	combine	VERB
ajst-19178	117	39	therapy	therapy	NOUN
ajst-19178	117	40	with	with	ADP
ajst-19178	117	41	anti	anti	ADJ
ajst-19178	117	42	-	-	ADJ
ajst-19178	117	43	tumor	tumor	ADJ
ajst-19178	117	44	drugs	drug	NOUN
ajst-19178	117	45	.	.	PUNCT
ajst-19178	118	1	200	200	NUM
ajst-19178	118	2	references	reference	NOUN
ajst-19178	118	3	[	[	X
ajst-19178	118	4	1	1	NUM
ajst-19178	118	5	]	]	PUNCT
ajst-19178	118	6	qi	qi	PROPN
ajst-19178	118	7	j	j	PROPN
ajst-19178	118	8	,	,	PUNCT
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ajst-19178	118	11	,	,	PUNCT
ajst-19178	118	12	wang	wang	PROPN
ajst-19178	118	13	l	l	PROPN
ajst-19178	118	14	,	,	PUNCT
ajst-19178	118	15	hu	hu	PROPN
ajst-19178	118	16	y	y	PROPN
ajst-19178	118	17	,	,	PUNCT
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ajst-19178	118	23	,	,	PUNCT
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ajst-19178	118	26	,	,	PUNCT
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ajst-19178	118	28	p	p	X
ajst-19178	118	29	,	,	PUNCT
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ajst-19178	118	45	:	:	PUNCT
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ajst-19178	120	3	-	-	PUNCT
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ajst-19178	120	9	/	/	SYM
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ajst-19178	120	11	-	-	PUNCT
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ajst-19178	120	13	-	-	SYM
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ajst-19178	120	15	.	.	PUNCT
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ajst-19178	121	2	:	:	PUNCT
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ajst-19178	121	4	.	.	PUNCT
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ajst-19178	122	3	]	]	PUNCT
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ajst-19178	122	17	,	,	PUNCT
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ajst-19178	122	19	.	.	PUNCT
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ajst-19178	123	3	j	j	PROPN
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ajst-19178	124	3	-	-	SYM
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ajst-19178	124	5	.	.	PUNCT
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ajst-19178	125	2	:	:	PUNCT
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ajst-19178	125	4	/	/	SYM
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ajst-19178	125	6	.	.	PUNCT
ajst-19178	126	1	pmid	pmid	NOUN
ajst-19178	126	2	:	:	PUNCT
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ajst-19178	126	4	.	.	PUNCT
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ajst-19178	130	4	.	.	PUNCT
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ajst-19178	131	6	.	.	PUNCT
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ajst-19178	132	2	:	:	PUNCT
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ajst-19178	132	4	;	;	PUNCT
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ajst-19178	132	6	:	:	PUNCT
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ajst-19178	132	8	.	.	PUNCT
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ajst-19178	135	4	;	;	PUNCT
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ajst-19178	137	13	/	/	SYM
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ajst-19178	138	8	.	.	PUNCT
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ajst-19178	163	1	doi	doi	NOUN
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ajst-19178	192	4	.	.	PUNCT
ajst-19178	193	1	[	[	X
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ajst-19178	193	3	]	]	X
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ajst-19178	193	17	.	.	PUNCT
ajst-19178	194	1	j	j	PROPN
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ajst-19178	195	2	-	-	PUNCT
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ajst-19178	195	6	.	.	PUNCT
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ajst-19178	196	6	.	.	PUNCT
ajst-19178	197	1	pmid	pmid	NOUN
ajst-19178	197	2	:	:	PUNCT
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ajst-19178	197	4	.	.	PUNCT
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ajst-19178	199	11	:	:	PUNCT
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ajst-19178	199	20	.	.	PUNCT
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ajst-19178	200	4	.	.	PUNCT
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ajst-19178	202	4	/	/	SYM
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ajst-19178	202	6	.	.	PUNCT
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ajst-19178	203	5	.	.	PUNCT
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ajst-19178	204	2	:	:	PUNCT
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ajst-19178	204	4	.	.	PUNCT
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ajst-19178	205	6	,	,	PUNCT
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ajst-19178	205	8	m	m	PROPN
ajst-19178	205	9	,	,	PUNCT
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ajst-19178	205	12	,	,	PUNCT
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ajst-19178	205	15	,	,	PUNCT
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ajst-19178	207	4	.	.	PUNCT
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ajst-19178	209	2	:	:	PUNCT
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ajst-19178	209	4	;	;	PUNCT
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ajst-19178	209	6	:	:	PUNCT
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ajst-19178	209	8	.	.	PUNCT
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ajst-19178	210	19	cns	cns	NOUN
ajst-19178	210	20	drugs	drug	NOUN
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ajst-19178	210	25	mcf-7	mcf-7	NOUN
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ajst-19178	210	28	ht-29	ht-29	PUNCT
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ajst-19178	210	39	.	.	PUNCT
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ajst-19178	211	2	.	.	PUNCT
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ajst-19178	212	4	.	.	PUNCT
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ajst-19178	213	2	:	:	PUNCT
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ajst-19178	213	4	;	;	PUNCT
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ajst-19178	213	6	:	:	PUNCT
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ajst-19178	213	8	.	.	PUNCT
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ajst-19178	214	12	.	.	PUNCT
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ajst-19178	215	8	:	:	PUNCT
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ajst-19178	215	13	.	.	PUNCT
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ajst-19178	217	4	-	-	PUNCT
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ajst-19178	217	6	.	.	PUNCT
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ajst-19178	218	2	:	:	PUNCT
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ajst-19178	218	9	:	:	PUNCT
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ajst-19178	219	2	:	:	PUNCT
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ajst-19178	219	4	.	.	PUNCT
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ajst-19178	221	2	,	,	PUNCT
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ajst-19178	221	20	.	.	PUNCT
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ajst-19178	225	2	:	:	PUNCT
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ajst-19178	225	6	:	:	PUNCT
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ajst-19178	229	5	.	.	PUNCT
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ajst-19178	230	6	-	-	PUNCT
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ajst-19178	230	8	-	-	PUNCT
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ajst-19178	230	10	-	-	SYM
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ajst-19178	231	5	.	.	PUNCT
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ajst-19178	232	8	.	.	PUNCT
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ajst-19178	233	30	.	.	PUNCT
ajst-19178	234	1	chem	chem	NOUN
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ajst-19178	234	4	.	.	PUNCT
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ajst-19178	235	4	-	-	SYM
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ajst-19178	237	5	.	.	PUNCT
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ajst-19178	238	2	:	:	PUNCT
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ajst-19178	239	8	c	c	PROPN
ajst-19178	239	9	,	,	PUNCT
ajst-19178	239	10	wang	wang	PROPN
ajst-19178	239	11	m	m	PROPN
ajst-19178	239	12	,	,	PUNCT
ajst-19178	239	13	he	he	PRON
ajst-19178	239	14	y	y	PROPN
ajst-19178	239	15	,	,	PUNCT
ajst-19178	239	16	guo	guo	PROPN
ajst-19178	239	17	z	z	PROPN
ajst-19178	239	18	,	,	PUNCT
ajst-19178	239	19	he	he	PRON
ajst-19178	239	20	j	j	PROPN
ajst-19178	239	21	,	,	PUNCT
ajst-19178	239	22	jiang	jiang	PROPN
ajst-19178	239	23	r	r	PROPN
ajst-19178	239	24	,	,	PUNCT
ajst-19178	239	25	xu	xu	PROPN
ajst-19178	240	1	q	q	PROPN
ajst-19178	240	2	,	,	PUNCT
ajst-19178	240	3	liang	liang	PROPN
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ajst-19178	240	5	,	,	PUNCT
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ajst-19178	240	7	s.	s.	PROPN
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ajst-19178	240	11	-	-	PUNCT
ajst-19178	240	12	artesunate	artesunate	NOUN
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ajst-19178	240	21	.	.	PUNCT
ajst-19178	241	1	j	j	PROPN
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ajst-19178	242	4	-	-	NOUN
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ajst-19178	242	6	.	.	PUNCT
ajst-19178	243	1	doi	doi	NOUN
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ajst-19178	243	6	.	.	PUNCT
ajst-19178	244	1	epub	epub	PROPN
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ajst-19178	244	5	.	.	PUNCT
ajst-19178	245	1	pmid	pmid	NOUN
ajst-19178	245	2	:	:	PUNCT
ajst-19178	245	3	37306362	37306362	NUM
ajst-19178	245	4	.	.	PUNCT
ajst-19178	246	1	[	[	X
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ajst-19178	246	4	li	li	PROPN
ajst-19178	246	5	w	w	PROPN
ajst-19178	246	6	,	,	PUNCT
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ajst-19178	246	9	,	,	PUNCT
ajst-19178	246	10	deng	deng	PROPN
ajst-19178	246	11	y	y	PROPN
ajst-19178	246	12	,	,	PUNCT
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ajst-19178	246	14	q	q	PROPN
ajst-19178	246	15	,	,	PUNCT
ajst-19178	246	16	wang	wang	PROPN
ajst-19178	246	17	z	z	PROPN
ajst-19178	246	18	,	,	PUNCT
ajst-19178	246	19	zhou	zhou	PROPN
ajst-19178	246	20	q.	q.	PROPN
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ajst-19178	246	23	synergistic	synergistic	ADJ
ajst-19178	246	24	anti	anti	ADJ
ajst-19178	246	25	-	-	ADJ
ajst-19178	246	26	cancer	cancer	ADJ
ajst-19178	246	27	effects	effect	NOUN
ajst-19178	246	28	with	with	ADP
ajst-19178	246	29	cisplatin	cisplatin	NOUN
ajst-19178	246	30	on	on	ADP
ajst-19178	246	31	lung	lung	NOUN
ajst-19178	246	32	cancer	cancer	NOUN
ajst-19178	246	33	a549	a549	PROPN
ajst-19178	246	34	cells	cell	NOUN
ajst-19178	246	35	by	by	ADP
ajst-19178	246	36	inhibiting	inhibit	VERB
ajst-19178	246	37	mapk	mapk	NOUN
ajst-19178	246	38	pathway	pathway	NOUN
ajst-19178	246	39	.	.	PUNCT
ajst-19178	247	1	gene	gene	NOUN
ajst-19178	247	2	.	.	PUNCT
ajst-19178	248	1	2021	2021	NUM
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ajst-19178	248	4	.	.	PUNCT
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ajst-19178	249	1	epub	epub	NOUN
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ajst-19178	249	5	.	.	PUNCT
ajst-19178	250	1	pmid	pmid	NOUN
ajst-19178	250	2	:	:	PUNCT
ajst-19178	250	3	32898605	32898605	NUM
ajst-19178	250	4	.	.	PUNCT
ajst-19178	251	1	[	[	X
ajst-19178	251	2	26	26	NUM
ajst-19178	251	3	]	]	X
ajst-19178	251	4	wang	wang	PROPN
ajst-19178	251	5	z	z	PROPN
ajst-19178	251	6	,	,	PUNCT
ajst-19178	251	7	wang	wang	PROPN
ajst-19178	251	8	q	q	PROPN
ajst-19178	251	9	,	,	PUNCT
ajst-19178	251	10	he	he	PRON
ajst-19178	251	11	t	t	PROPN
ajst-19178	251	12	,	,	PUNCT
ajst-19178	251	13	li	li	PROPN
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ajst-19178	251	15	,	,	PUNCT
ajst-19178	251	16	liu	liu	PROPN
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ajst-19178	251	18	,	,	PUNCT
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ajst-19178	251	21	,	,	PUNCT
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ajst-19178	251	23	y	y	PROPN
ajst-19178	251	24	,	,	PUNCT
ajst-19178	251	25	wang	wang	PROPN
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ajst-19178	251	36	exerts	exert	VERB
ajst-19178	251	37	a	a	DET
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ajst-19178	251	49	cancer	cancer	NOUN
ajst-19178	251	50	.	.	PUNCT
ajst-19178	252	1	clin	clin	PROPN
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ajst-19178	253	1	2020	2020	NUM
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ajst-19178	254	2	.	.	PROPN
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ajst-19178	254	4	:	:	PUNCT
ajst-19178	254	5	10.1111/1440	10.1111/1440	NUM
ajst-19178	254	6	-	-	PUNCT
ajst-19178	254	7	1681.13287	1681.13287	NOUN
ajst-19178	254	8	.	.	PUNCT
ajst-19178	255	1	epub	epub	NOUN
ajst-19178	255	2	2020	2020	NUM
ajst-19178	255	3	mar	mar	PROPN
ajst-19178	255	4	20	20	NUM
ajst-19178	255	5	.	.	PUNCT
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ajst-19178	256	2	:	:	PUNCT
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ajst-19178	256	4	.	.	PUNCT
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ajst-19178	257	3	]	]	PUNCT
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ajst-19178	257	5	v	v	PROPN
ajst-19178	257	6	,	,	PUNCT
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ajst-19178	257	9	,	,	PUNCT
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ajst-19178	257	12	,	,	PUNCT
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ajst-19178	257	14	g	g	PROPN
ajst-19178	257	15	,	,	PUNCT
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ajst-19178	257	20	s.	s.	PROPN
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ajst-19178	257	25	-	-	PUNCT
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ajst-19178	257	27	:	:	PUNCT
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ajst-19178	257	34	novel	novel	VERB
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ajst-19178	259	4	-	-	SYM
ajst-19178	259	5	3512	3512	NUM
ajst-19178	259	6	.	.	PUNCT
ajst-19178	260	1	doi	doi	NOUN
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ajst-19178	260	11	.	.	PUNCT
ajst-19178	261	1	pmid	pmid	NOUN
ajst-19178	261	2	:	:	PUNCT
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ajst-19178	261	6	:	:	PUNCT
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ajst-19178	261	8	.	.	PUNCT
ajst-19178	262	1	[	[	X
ajst-19178	262	2	28	28	NUM
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ajst-19178	264	4	.	.	PUNCT
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ajst-19178	265	4	.	.	PUNCT
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ajst-19178	266	8	.	.	PUNCT
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ajst-19178	267	32	-	-	PUNCT
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ajst-19178	271	1	pmid	pmid	NOUN
ajst-19178	271	2	:	:	PUNCT
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ajst-19178	271	4	;	;	PUNCT
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ajst-19178	271	6	:	:	PUNCT
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ajst-19178	271	8	.	.	PUNCT
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ajst-19178	272	23	cf	cf	PROPN
ajst-19178	272	24	,	,	PUNCT
ajst-19178	272	25	chen	chen	PROPN
ajst-19178	272	26	x	x	PROPN
ajst-19178	272	27	,	,	PUNCT
ajst-19178	272	28	tu	tu	PROPN
ajst-19178	272	29	cq	cq	PROPN
ajst-19178	272	30	.	.	PUNCT
ajst-19178	273	1	[	[	X
ajst-19178	273	2	the	the	DET
ajst-19178	273	3	mechanism	mechanism	NOUN
ajst-19178	273	4	of	of	ADP
ajst-19178	273	5	artesunate	artesunate	NOUN
ajst-19178	273	6	combined	combine	VERB
ajst-19178	273	7	with	with	ADP
ajst-19178	273	8	cytarabine	cytarabine	NOUN
ajst-19178	273	9	and/or	and/or	CCONJ
ajst-19178	273	10	daunorubicin	daunorubicin	VERB
ajst-19178	273	11	on	on	ADP
ajst-19178	273	12	the	the	DET
ajst-19178	273	13	apoptosis	apoptosis	NOUN
ajst-19178	273	14	of	of	ADP
ajst-19178	273	15	mv4	mv4	PROPN
ajst-19178	273	16	-	-	ADJ
ajst-19178	273	17	11	11	NUM
ajst-19178	273	18	mll	mll	PROPN
ajst-19178	273	19	-	-	PUNCT
ajst-19178	273	20	rearranged	rearrange	VERB
ajst-19178	273	21	acute	acute	ADJ
ajst-19178	273	22	myeloid	myeloid	NOUN
ajst-19178	273	23	leukemia	leukemia	NOUN
ajst-19178	273	24	cell	cell	NOUN
ajst-19178	273	25	line	line	NOUN
ajst-19178	273	26	]	]	PUNCT
ajst-19178	273	27	.	.	PUNCT
ajst-19178	274	1	zhongguo	zhongguo	PROPN
ajst-19178	274	2	shi	shi	PROPN
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ajst-19178	275	1	xue	xue	PROPN
ajst-19178	275	2	ye	ye	PROPN
ajst-19178	275	3	xue	xue	PROPN
ajst-19178	275	4	za	za	PROPN
ajst-19178	275	5	zhi	zhi	PROPN
ajst-19178	275	6	.	.	PUNCT
ajst-19178	276	1	2022	2022	NUM
ajst-19178	276	2	dec;30(6):1724	dec;30(6):1724	PROPN
ajst-19178	276	3	-	-	PUNCT
ajst-19178	276	4	1729	1729	NUM
ajst-19178	276	5	.	.	PUNCT
ajst-19178	277	1	chinese	chinese	PROPN
ajst-19178	277	2	.	.	PUNCT
ajst-19178	278	1	doi	doi	NOUN
ajst-19178	278	2	:	:	PUNCT
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ajst-19178	278	4	/	/	SYM
ajst-19178	278	5	j.cnki.issn.1009	j.cnki.issn.1009	NOUN
ajst-19178	278	6	-	-	PUNCT
ajst-19178	278	7	2137.2022.06.015	2137.2022.06.015	PROPN
ajst-19178	278	8	.	.	PUNCT
ajst-19178	279	1	pmid	pmid	NOUN
ajst-19178	279	2	:	:	PUNCT
ajst-19178	279	3	36476895	36476895	NUM
ajst-19178	279	4	.	.	PUNCT
ajst-19178	280	1	[	[	X
ajst-19178	280	2	31	31	NUM
ajst-19178	280	3	]	]	X
ajst-19178	280	4	zhang	zhang	PROPN
ajst-19178	280	5	j	j	PROPN
ajst-19178	280	6	,	,	PUNCT
ajst-19178	280	7	wang	wang	PROPN
ajst-19178	280	8	y	y	PROPN
ajst-19178	280	9	,	,	PUNCT
ajst-19178	280	10	yin	yin	PROPN
ajst-19178	280	11	c	c	AUX
ajst-19178	280	12	,	,	PUNCT
ajst-19178	280	13	gong	gong	NOUN
ajst-19178	280	14	p	p	X
ajst-19178	280	15	,	,	PUNCT
ajst-19178	280	16	zhang	zhang	PROPN
ajst-19178	280	17	z	z	PROPN
ajst-19178	280	18	,	,	PUNCT
ajst-19178	280	19	zhao	zhao	PROPN
ajst-19178	280	20	l	l	PROPN
ajst-19178	280	21	,	,	PUNCT
ajst-19178	280	22	waxman	waxman	PROPN
ajst-19178	280	23	s	s	PROPN
ajst-19178	280	24	,	,	PUNCT
ajst-19178	280	25	jing	jing	ADJ
ajst-19178	280	26	y.	y.	PROPN
ajst-19178	280	27	artesunate	artesunate	PROPN
ajst-19178	280	28	improves	improve	VERB
ajst-19178	280	29	venetoclax	venetoclax	NOUN
ajst-19178	280	30	plus	plus	CCONJ
ajst-19178	280	31	cytarabine	cytarabine	PROPN
ajst-19178	280	32	aml	aml	PROPN
ajst-19178	280	33	cell	cell	NOUN
ajst-19178	280	34	targeting	target	VERB
ajst-19178	280	35	by	by	ADP
ajst-19178	280	36	regulating	regulate	VERB
ajst-19178	280	37	the	the	DET
ajst-19178	280	38	noxa	noxa	NOUN
ajst-19178	280	39	/	/	SYM
ajst-19178	280	40	bim	bim	NOUN
ajst-19178	280	41	/	/	SYM
ajst-19178	280	42	mcl-1	mcl-1	NOUN
ajst-19178	280	43	/	/	SYM
ajst-19178	280	44	p	p	ADJ
ajst-19178	280	45	-	-	PUNCT
ajst-19178	280	46	chk1	chk1	ADJ
ajst-19178	280	47	axis	axis	NOUN
ajst-19178	280	48	.	.	PUNCT
ajst-19178	281	1	cell	cell	NOUN
ajst-19178	281	2	death	death	NOUN
ajst-19178	281	3	dis	dis	PROPN
ajst-19178	281	4	.	.	PUNCT
ajst-19178	282	1	2022	2022	NUM
ajst-19178	282	2	apr	apr	PROPN
ajst-19178	282	3	20;13(4):379	20;13(4):379	PROPN
ajst-19178	282	4	.	.	PUNCT
ajst-19178	282	5	doi	doi	PROPN
ajst-19178	282	6	:	:	PUNCT
ajst-19178	282	7	10.1038	10.1038	NUM
ajst-19178	282	8	/	/	SYM
ajst-19178	282	9	s41419	s41419	NUM
ajst-19178	282	10	-	-	NOUN
ajst-19178	282	11	022	022	NUM
ajst-19178	282	12	-	-	PUNCT
ajst-19178	282	13	04810	04810	NUM
ajst-19178	282	14	-	-	PUNCT
ajst-19178	282	15	z.	z.	PROPN
ajst-19178	282	16	pmid	pmid	PROPN
ajst-19178	282	17	:	:	PUNCT
ajst-19178	282	18	35443722	35443722	NUM
ajst-19178	282	19	;	;	PUNCT
ajst-19178	282	20	pmcid	pmcid	ADJ
ajst-19178	282	21	:	:	PUNCT
ajst-19178	282	22	pmc9021233	pmc9021233	NOUN
ajst-19178	282	23	.	.	PUNCT
ajst-19178	283	1	[	[	X
ajst-19178	283	2	32	32	NUM
ajst-19178	283	3	]	]	SYM
ajst-19178	283	4	su	su	PROPN
ajst-19178	283	5	q	q	PROPN
ajst-19178	283	6	,	,	PUNCT
ajst-19178	283	7	huang	huang	PROPN
ajst-19178	283	8	p	p	PROPN
ajst-19178	283	9	,	,	PUNCT
ajst-19178	283	10	luo	luo	PROPN
ajst-19178	283	11	x	x	PROPN
ajst-19178	283	12	,	,	PUNCT
ajst-19178	283	13	zhang	zhang	PROPN
ajst-19178	283	14	p	p	PROPN
ajst-19178	283	15	,	,	PUNCT
ajst-19178	283	16	li	li	PROPN
ajst-19178	283	17	h	h	PROPN
ajst-19178	283	18	,	,	PUNCT
ajst-19178	283	19	chen	chen	PROPN
ajst-19178	283	20	y.	y.	PROPN
ajst-19178	283	21	artesunate	artesunate	PROPN
ajst-19178	283	22	reverses	reverse	VERB
ajst-19178	283	23	cytarabine	cytarabine	NOUN
ajst-19178	283	24	resistance	resistance	NOUN
ajst-19178	283	25	in	in	ADP
ajst-19178	283	26	acute	acute	ADJ
ajst-19178	283	27	myeloid	myeloid	NOUN
ajst-19178	283	28	leukemia	leukemia	NOUN
ajst-19178	283	29	by	by	ADP
ajst-19178	283	30	blocking	block	VERB
ajst-19178	283	31	the	the	DET
ajst-19178	283	32	jak	jak	PROPN
ajst-19178	283	33	/	/	SYM
ajst-19178	283	34	stat3	stat3	NOUN
ajst-19178	283	35	signaling	signaling	NOUN
ajst-19178	283	36	.	.	PUNCT
ajst-19178	284	1	hematology	hematology	NOUN
ajst-19178	284	2	.	.	PUNCT
ajst-19178	285	1	2023	2023	NUM
ajst-19178	285	2	dec;28(1):2255802	dec;28(1):2255802	PROPN
ajst-19178	285	3	.	.	PROPN
ajst-19178	285	4	doi	doi	PROPN
ajst-19178	285	5	:	:	PUNCT
ajst-19178	285	6	10.1080/16078454.2023.2255802	10.1080/16078454.2023.2255802	NUM
ajst-19178	285	7	.	.	PUNCT
ajst-19178	286	1	epub	epub	NOUN
ajst-19178	286	2	2023	2023	NUM
ajst-19178	286	3	oct	oct	NOUN
ajst-19178	286	4	10	10	NUM
ajst-19178	286	5	.	.	PUNCT
ajst-19178	287	1	pmid	pmid	NOUN
ajst-19178	287	2	:	:	PUNCT
ajst-19178	287	3	37815490	37815490	NUM
ajst-19178	287	4	.	.	PUNCT
ajst-19178	288	1	[	[	X
ajst-19178	288	2	33	33	NUM
ajst-19178	288	3	]	]	X
ajst-19178	288	4	efferth	efferth	ADJ
ajst-19178	288	5	t.	t.	NOUN
ajst-19178	288	6	cancer	cancer	NOUN
ajst-19178	288	7	combination	combination	NOUN
ajst-19178	288	8	therapy	therapy	NOUN
ajst-19178	288	9	of	of	ADP
ajst-19178	288	10	the	the	DET
ajst-19178	288	11	sesquiterpenoid	sesquiterpenoid	NOUN
ajst-19178	288	12	artesunate	artesunate	NOUN
ajst-19178	288	13	and	and	CCONJ
ajst-19178	288	14	the	the	DET
ajst-19178	288	15	selective	selective	ADJ
ajst-19178	288	16	egfr	egfr	ADJ
ajst-19178	288	17	-	-	PUNCT
ajst-19178	288	18	tyrosine	tyrosine	NOUN
ajst-19178	288	19	kinase	kinase	PROPN
ajst-19178	288	20	inhibitor	inhibitor	PROPN
ajst-19178	288	21	erlotinib	erlotinib	PROPN
ajst-19178	288	22	.	.	PUNCT
ajst-19178	289	1	phytomedicine	phytomedicine	NOUN
ajst-19178	289	2	.	.	PUNCT
ajst-19178	290	1	2017	2017	NUM
ajst-19178	290	2	dec	dec	PROPN
ajst-19178	290	3	15;37:58	15;37:58	NUM
ajst-19178	290	4	-	-	SYM
ajst-19178	290	5	61	61	NUM
ajst-19178	290	6	.	.	PUNCT
ajst-19178	291	1	doi	doi	NOUN
ajst-19178	291	2	:	:	PUNCT
ajst-19178	291	3	10.1016	10.1016	NUM
ajst-19178	291	4	/	/	SYM
ajst-19178	291	5	j.phymed.2017.11.003	j.phymed.2017.11.003	PROPN
ajst-19178	291	6	.	.	PUNCT
ajst-19178	292	1	epub	epub	PROPN
ajst-19178	292	2	2017	2017	NUM
ajst-19178	292	3	nov	nov	PROPN
ajst-19178	292	4	10	10	NUM
ajst-19178	292	5	.	.	PUNCT
ajst-19178	293	1	pmid	pmid	NOUN
ajst-19178	293	2	:	:	PUNCT
ajst-19178	293	3	29174651	29174651	NUM
ajst-19178	293	4	.	.	PUNCT
ajst-19178	294	1	[	[	X
ajst-19178	294	2	34	34	NUM
ajst-19178	294	3	]	]	X
ajst-19178	294	4	yao	yao	NOUN
ajst-19178	294	5	x	x	X
ajst-19178	294	6	,	,	PUNCT
ajst-19178	294	7	zhao	zhao	PROPN
ajst-19178	294	8	cr	cr	PROPN
ajst-19178	294	9	,	,	PUNCT
ajst-19178	294	10	yin	yin	PROPN
ajst-19178	294	11	h	h	PROPN
ajst-19178	294	12	,	,	PUNCT
ajst-19178	294	13	wang	wang	PROPN
ajst-19178	294	14	k	k	PROPN
ajst-19178	294	15	,	,	PUNCT
ajst-19178	294	16	gao	gao	PROPN
ajst-19178	294	17	jj	jj	PROPN
ajst-19178	294	18	.	.	PROPN
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ajst-19178	294	21	activity	activity	NOUN
ajst-19178	294	22	of	of	ADP
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ajst-19178	294	24	and	and	CCONJ
ajst-19178	294	25	artesunate	artesunate	VERB
ajst-19178	294	26	in	in	ADP
ajst-19178	294	27	hepatocellular	hepatocellular	ADJ
ajst-19178	294	28	carcinoma	carcinoma	NOUN
ajst-19178	294	29	cells	cell	NOUN
ajst-19178	294	30	.	.	PUNCT
ajst-19178	295	1	acta	acta	PROPN
ajst-19178	295	2	pharmacol	pharmacol	PROPN
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ajst-19178	295	4	.	.	PUNCT
ajst-19178	296	1	2020	2020	NUM
ajst-19178	296	2	dec;41(12):16091620	dec;41(12):16091620	PROPN
ajst-19178	296	3	.	.	PUNCT
ajst-19178	297	1	doi	doi	NOUN
ajst-19178	297	2	:	:	PUNCT
ajst-19178	297	3	10.1038	10.1038	NUM
ajst-19178	297	4	/	/	SYM
ajst-19178	297	5	s41401	s41401	NOUN
ajst-19178	297	6	-	-	PUNCT
ajst-19178	297	7	020	020	NUM
ajst-19178	297	8	-	-	PUNCT
ajst-19178	297	9	0395	0395	NUM
ajst-19178	297	10	-	-	PUNCT
ajst-19178	297	11	5	5	NUM
ajst-19178	297	12	.	.	PUNCT
ajst-19178	298	1	epub	epub	NOUN
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ajst-19178	298	5	.	.	PUNCT
ajst-19178	299	1	pmid	pmid	NOUN
ajst-19178	299	2	:	:	PUNCT
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ajst-19178	299	4	;	;	PUNCT
ajst-19178	299	5	pmcid	pmcid	NOUN
ajst-19178	299	6	:	:	PUNCT
ajst-19178	299	7	pmc7921114	pmc7921114	VERB
ajst-19178	299	8	.	.	PUNCT
ajst-19178	300	1	[	[	X
ajst-19178	300	2	35	35	NUM
ajst-19178	300	3	]	]	X
ajst-19178	300	4	li	li	PROPN
ajst-19178	300	5	zj	zj	PROPN
ajst-19178	300	6	,	,	PUNCT
ajst-19178	300	7	dai	dai	PROPN
ajst-19178	300	8	hq	hq	PROPN
ajst-19178	300	9	,	,	PUNCT
ajst-19178	300	10	huang	huang	PROPN
ajst-19178	300	11	xw	xw	PROPN
ajst-19178	300	12	,	,	PUNCT
ajst-19178	300	13	feng	feng	PROPN
ajst-19178	300	14	j	j	PROPN
ajst-19178	300	15	,	,	PUNCT
ajst-19178	300	16	deng	deng	PROPN
ajst-19178	300	17	jh	jh	PROPN
ajst-19178	300	18	,	,	PUNCT
ajst-19178	300	19	wang	wang	PROPN
ajst-19178	300	20	zx	zx	PROPN
ajst-19178	300	21	,	,	PUNCT
ajst-19178	300	22	yang	yang	PROPN
ajst-19178	300	23	xm	xm	PROPN
ajst-19178	300	24	,	,	PUNCT
ajst-19178	300	25	liu	liu	PROPN
ajst-19178	300	26	yj	yj	PROPN
ajst-19178	300	27	,	,	PUNCT
ajst-19178	300	28	wu	wu	PROPN
ajst-19178	300	29	y	y	PROPN
ajst-19178	300	30	,	,	PUNCT
ajst-19178	300	31	chen	chen	PROPN
ajst-19178	300	32	ph	ph	PROPN
ajst-19178	300	33	,	,	PUNCT
ajst-19178	300	34	shi	shi	PROPN
ajst-19178	300	35	h	h	PROPN
ajst-19178	300	36	,	,	PUNCT
ajst-19178	300	37	wang	wang	PROPN
ajst-19178	300	38	jg	jg	PROPN
ajst-19178	300	39	,	,	PUNCT
ajst-19178	300	40	zhou	zhou	PROPN
ajst-19178	300	41	j	j	PROPN
ajst-19178	300	42	,	,	PUNCT
ajst-19178	300	43	lu	lu	PROPN
ajst-19178	300	44	gd	gd	PROPN
ajst-19178	300	45	.	.	PUNCT
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ajst-19178	300	55	carcinoma	carcinoma	NOUN
ajst-19178	300	56	.	.	PUNCT
ajst-19178	301	1	acta	acta	PROPN
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ajst-19178	302	3	-	-	SYM
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ajst-19178	302	5	.	.	PUNCT
ajst-19178	303	1	doi	doi	NOUN
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ajst-19178	303	6	-	-	PUNCT
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ajst-19178	303	8	-	-	PUNCT
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ajst-19178	303	10	-	-	PUNCT
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ajst-19178	303	12	.	.	PUNCT
ajst-19178	304	1	epub	epub	NOUN
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ajst-19178	304	5	.	.	PUNCT
ajst-19178	305	1	pmid	pmid	NOUN
ajst-19178	305	2	:	:	PUNCT
ajst-19178	305	3	32699265	32699265	NUM
ajst-19178	305	4	;	;	PUNCT
ajst-19178	305	5	pmcid	pmcid	ADJ
ajst-19178	305	6	:	:	PUNCT
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ajst-19178	305	8	.	.	PUNCT
ajst-19178	306	1	[	[	X
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ajst-19178	306	3	]	]	X
ajst-19178	306	4	chen	chen	PROPN
ajst-19178	306	5	m	m	PROPN
ajst-19178	306	6	,	,	PUNCT
ajst-19178	306	7	wu	wu	PROPN
ajst-19178	306	8	hl	hl	PROPN
ajst-19178	306	9	,	,	PUNCT
ajst-19178	306	10	wong	wong	PROPN
ajst-19178	306	11	ts	ts	PROPN
ajst-19178	306	12	,	,	PUNCT
ajst-19178	306	13	chen	chen	PROPN
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ajst-19178	306	16	gong	gong	PROPN
ajst-19178	306	17	rh	rh	PROPN
ajst-19178	306	18	,	,	PUNCT
ajst-19178	306	19	wong	wong	PROPN
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ajst-19178	306	21	,	,	PUNCT
ajst-19178	306	22	xiao	xiao	PROPN
ajst-19178	306	23	h	h	PROPN
ajst-19178	306	24	,	,	PUNCT
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ajst-19178	308	4	.	.	PUNCT
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ajst-19178	310	8	.	.	PUNCT
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ajst-19178	311	48	.	.	PUNCT
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ajst-19178	314	5	.	.	PUNCT
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ajst-19178	315	2	:	:	PUNCT
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ajst-19178	315	4	;	;	PUNCT
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ajst-19178	315	6	:	:	PUNCT
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ajst-19178	315	8	.	.	PUNCT
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ajst-19178	319	6	.	.	PUNCT
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ajst-19178	320	5	.	.	PUNCT
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ajst-19178	321	4	;	;	PUNCT
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ajst-19178	321	8	.	.	PUNCT
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ajst-19178	334	5	.	.	PUNCT
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ajst-19178	339	8	.	.	PUNCT
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ajst-19178	341	5	.	.	PUNCT
ajst-19178	342	1	2019	2019	NUM
ajst-19178	342	2	oct	oct	NOUN
ajst-19178	342	3	29;519(1):41	29;519(1):41	NUM
ajst-19178	342	4	-	-	SYM
ajst-19178	342	5	45	45	NUM
ajst-19178	342	6	.	.	PUNCT
ajst-19178	343	1	doi	doi	NOUN
ajst-19178	343	2	:	:	PUNCT
ajst-19178	343	3	10.1016	10.1016	NUM
ajst-19178	343	4	/	/	SYM
ajst-19178	343	5	j.bbrc.2019.08.115	j.bbrc.2019.08.115	PROPN
ajst-19178	343	6	.	.	PUNCT
ajst-19178	344	1	epub	epub	PROPN
ajst-19178	344	2	2019	2019	NUM
ajst-19178	344	3	aug	aug	PROPN
ajst-19178	344	4	31	31	NUM
ajst-19178	344	5	.	.	PUNCT
ajst-19178	345	1	pmid	pmid	NOUN
ajst-19178	345	2	:	:	PUNCT
ajst-19178	345	3	31481232	31481232	NUM
ajst-19178	345	4	.	.	PUNCT
ajst-19178	346	1	[	[	X
ajst-19178	346	2	43	43	NUM
ajst-19178	346	3	]	]	X
ajst-19178	346	4	yang	yang	PROPN
ajst-19178	346	5	t	t	PROPN
ajst-19178	346	6	,	,	PUNCT
ajst-19178	346	7	zhang	zhang	PROPN
ajst-19178	346	8	s	s	PROPN
ajst-19178	346	9	,	,	PUNCT
ajst-19178	346	10	yuan	yuan	NOUN
ajst-19178	346	11	h	h	NOUN
ajst-19178	346	12	,	,	PUNCT
ajst-19178	346	13	wang	wang	PROPN
ajst-19178	346	14	y	y	PROPN
ajst-19178	346	15	,	,	PUNCT
ajst-19178	346	16	cai	cai	PROPN
ajst-19178	346	17	l	l	PROPN
ajst-19178	346	18	,	,	PUNCT
ajst-19178	346	19	chen	chen	PROPN
ajst-19178	346	20	h	h	PROPN
ajst-19178	346	21	,	,	PUNCT
ajst-19178	346	22	wang	wang	PROPN
ajst-19178	346	23	x	x	PROPN
ajst-19178	346	24	,	,	PUNCT
ajst-19178	346	25	song	song	NOUN
ajst-19178	346	26	d	d	PROPN
ajst-19178	346	27	,	,	PUNCT
ajst-19178	346	28	wang	wang	PROPN
ajst-19178	346	29	x	x	PROPN
ajst-19178	346	30	,	,	PUNCT
ajst-19178	346	31	guo	guo	PROPN
ajst-19178	346	32	z	z	PROPN
ajst-19178	346	33	,	,	PUNCT
ajst-19178	346	34	wang	wang	PROPN
ajst-19178	346	35	x.	x.	PROPN
ajst-19178	346	36	platinum	platinum	NOUN
ajst-19178	346	37	-	-	PUNCT
ajst-19178	346	38	based	base	VERB
ajst-19178	346	39	trem2	trem2	NOUN
ajst-19178	346	40	inhibitor	inhibitor	NOUN
ajst-19178	346	41	suppresses	suppress	VERB
ajst-19178	346	42	tumors	tumor	NOUN
ajst-19178	346	43	by	by	ADP
ajst-19178	346	44	remodeling	remodel	VERB
ajst-19178	346	45	the	the	DET
ajst-19178	346	46	immunosuppressive	immunosuppressive	ADJ
ajst-19178	346	47	microenvironment	microenvironment	NOUN
ajst-19178	346	48	.	.	PUNCT
ajst-19178	347	1	angew	angew	PROPN
ajst-19178	347	2	chem	chem	PROPN
ajst-19178	347	3	int	int	PROPN
ajst-19178	347	4	ed	ed	PROPN
ajst-19178	347	5	engl	engl	PROPN
ajst-19178	347	6	.	.	PUNCT
ajst-19178	348	1	2023	2023	NUM
ajst-19178	348	2	jan	jan	PROPN
ajst-19178	348	3	9;62(2):e202213337	9;62(2):e202213337	PROPN
ajst-19178	348	4	.	.	PUNCT
ajst-19178	349	1	doi	doi	NOUN
ajst-19178	349	2	:	:	PUNCT
ajst-19178	349	3	10.1002	10.1002	NUM
ajst-19178	349	4	/	/	SYM
ajst-19178	349	5	anie.202213337	anie.202213337	PROPN
ajst-19178	349	6	.	.	PUNCT
ajst-19178	350	1	epub	epub	PROPN
ajst-19178	350	2	2022	2022	NUM
ajst-19178	350	3	dec	dec	PROPN
ajst-19178	350	4	7	7	NUM
ajst-19178	350	5	.	.	PUNCT
ajst-19178	351	1	pmid	pmid	NOUN
ajst-19178	351	2	:	:	PUNCT
ajst-19178	351	3	36259513	36259513	NUM
ajst-19178	351	4	.	.	PUNCT