id	sid	tid	token	lemma	pos
ajst-23566	1	1	academic	academic	ADJ
ajst-23566	1	2	journal	journal	NOUN
ajst-23566	1	3	of	of	ADP
ajst-23566	1	4	science	science	NOUN
ajst-23566	1	5	and	and	CCONJ
ajst-23566	1	6	technology	technology	NOUN
ajst-23566	1	7	issn	issn	NOUN
ajst-23566	1	8	:	:	PUNCT
ajst-23566	1	9	2771	2771	NUM
ajst-23566	1	10	-	-	SYM
ajst-23566	1	11	3032	3032	NUM
ajst-23566	1	12	|	|	NOUN
ajst-23566	1	13	vol	vol	NOUN
ajst-23566	1	14	.	.	PROPN
ajst-23566	2	1	11	11	NUM
ajst-23566	2	2	,	,	PUNCT
ajst-23566	2	3	no	no	INTJ
ajst-23566	2	4	.	.	NOUN
ajst-23566	2	5	3	3	NUM
ajst-23566	2	6	,	,	PUNCT
ajst-23566	2	7	2024	2024	NUM
ajst-23566	2	8	102	102	NUM
ajst-23566	2	9	current	current	ADJ
ajst-23566	2	10	status	status	NOUN
ajst-23566	2	11	of	of	ADP
ajst-23566	2	12	breeding	breeding	NOUN
ajst-23566	2	13	of	of	ADP
ajst-23566	2	14	avermectin‐producing	avermectin‐produce	VERB
ajst-23566	2	15	bacteria	bacteria	NOUN
ajst-23566	2	16	manshi	manshi	NOUN
ajst-23566	2	17	ruan	ruan	PROPN
ajst-23566	2	18	*	*	PUNCT
ajst-23566	3	1	school	school	NOUN
ajst-23566	3	2	of	of	ADP
ajst-23566	3	3	life	life	NOUN
ajst-23566	3	4	science	science	NOUN
ajst-23566	3	5	and	and	CCONJ
ajst-23566	3	6	technology	technology	NOUN
ajst-23566	3	7	,	,	PUNCT
ajst-23566	3	8	lingnan	lingnan	ADJ
ajst-23566	3	9	normal	normal	ADJ
ajst-23566	3	10	university	university	NOUN
ajst-23566	3	11	,	,	PUNCT
ajst-23566	3	12	zhanjiang	zhanjiang	PROPN
ajst-23566	3	13	,	,	PUNCT
ajst-23566	3	14	guangdong	guangdong	PROPN
ajst-23566	3	15	,	,	PUNCT
ajst-23566	3	16	524048	524048	NUM
ajst-23566	3	17	,	,	PUNCT
ajst-23566	3	18	china	china	PROPN
ajst-23566	3	19	*	*	PUNCT
ajst-23566	3	20	corresponding	correspond	VERB
ajst-23566	3	21	author	author	NOUN
ajst-23566	3	22	email	email	NOUN
ajst-23566	3	23	:	:	PUNCT
ajst-23566	3	24	rms0510mancy@163.com	rms0510mancy@163.com	X
ajst-23566	4	1	abstract	abstract	ADJ
ajst-23566	4	2	:	:	PUNCT
ajst-23566	4	3	avilamycin	avilamycin	ADV
ajst-23566	4	4	,	,	PUNCT
ajst-23566	4	5	also	also	ADV
ajst-23566	4	6	known	know	VERB
ajst-23566	4	7	as	as	ADP
ajst-23566	4	8	peomycin	peomycin	NOUN
ajst-23566	4	9	,	,	PUNCT
ajst-23566	4	10	is	be	AUX
ajst-23566	4	11	a	a	DET
ajst-23566	4	12	product	product	NOUN
ajst-23566	4	13	of	of	ADP
ajst-23566	4	14	ventilated	ventilate	VERB
ajst-23566	4	15	fermentation	fermentation	NOUN
ajst-23566	4	16	of	of	ADP
ajst-23566	4	17	streptomyces	streptomyce	NOUN
ajst-23566	4	18	viridochromogene	viridochromogene	NOUN
ajst-23566	4	19	.	.	PUNCT
ajst-23566	5	1	the	the	DET
ajst-23566	5	2	aim	aim	NOUN
ajst-23566	5	3	of	of	ADP
ajst-23566	5	4	this	this	DET
ajst-23566	5	5	paper	paper	NOUN
ajst-23566	5	6	is	be	AUX
ajst-23566	5	7	to	to	PART
ajst-23566	5	8	provide	provide	VERB
ajst-23566	5	9	a	a	DET
ajst-23566	5	10	comprehensive	comprehensive	ADJ
ajst-23566	5	11	overview	overview	NOUN
ajst-23566	5	12	of	of	ADP
ajst-23566	5	13	the	the	DET
ajst-23566	5	14	current	current	ADJ
ajst-23566	5	15	status	status	NOUN
ajst-23566	5	16	of	of	ADP
ajst-23566	5	17	breeding	breed	VERB
ajst-23566	5	18	avilamycin	avilamycin	NOUN
ajst-23566	5	19	-	-	PUNCT
ajst-23566	5	20	producing	produce	VERB
ajst-23566	5	21	bacteria	bacteria	NOUN
ajst-23566	5	22	and	and	CCONJ
ajst-23566	5	23	to	to	PART
ajst-23566	5	24	discuss	discuss	VERB
ajst-23566	5	25	in	in	ADP
ajst-23566	5	26	depth	depth	NOUN
ajst-23566	5	27	their	their	PRON
ajst-23566	5	28	physicochemical	physicochemical	ADJ
ajst-23566	5	29	properties	property	NOUN
ajst-23566	5	30	,	,	PUNCT
ajst-23566	5	31	breeding	breeding	NOUN
ajst-23566	5	32	techniques	technique	NOUN
ajst-23566	5	33	,	,	PUNCT
ajst-23566	5	34	and	and	CCONJ
ajst-23566	5	35	future	future	ADJ
ajst-23566	5	36	development	development	NOUN
ajst-23566	5	37	directions	direction	NOUN
ajst-23566	5	38	and	and	CCONJ
ajst-23566	5	39	strategies	strategy	NOUN
ajst-23566	5	40	.	.	PUNCT
ajst-23566	6	1	modern	modern	ADJ
ajst-23566	6	2	biotechnological	biotechnological	ADJ
ajst-23566	6	3	tools	tool	NOUN
ajst-23566	6	4	,	,	PUNCT
ajst-23566	6	5	such	such	ADJ
ajst-23566	6	6	as	as	ADP
ajst-23566	6	7	gene	gene	NOUN
ajst-23566	6	8	editing	editing	NOUN
ajst-23566	6	9	and	and	CCONJ
ajst-23566	6	10	genomics	genomic	NOUN
ajst-23566	6	11	analysis	analysis	NOUN
ajst-23566	6	12	,	,	PUNCT
ajst-23566	6	13	were	be	AUX
ajst-23566	6	14	used	use	VERB
ajst-23566	6	15	to	to	PART
ajst-23566	6	16	accelerate	accelerate	VERB
ajst-23566	6	17	the	the	DET
ajst-23566	6	18	breeding	breeding	NOUN
ajst-23566	6	19	progress	progress	NOUN
ajst-23566	6	20	of	of	ADP
ajst-23566	6	21	avilamycin	avilamycin	NOUN
ajst-23566	6	22	with	with	ADP
ajst-23566	6	23	a	a	DET
ajst-23566	6	24	view	view	NOUN
ajst-23566	6	25	to	to	ADP
ajst-23566	6	26	realizing	realize	VERB
ajst-23566	6	27	further	further	ADJ
ajst-23566	6	28	improvement	improvement	NOUN
ajst-23566	6	29	in	in	ADP
ajst-23566	6	30	its	its	PRON
ajst-23566	6	31	yield	yield	NOUN
ajst-23566	6	32	and	and	CCONJ
ajst-23566	6	33	quality	quality	NOUN
ajst-23566	6	34	.	.	PUNCT
ajst-23566	7	1	keywords	keyword	NOUN
ajst-23566	7	2	:	:	PUNCT
ajst-23566	7	3	avilamycin	avilamycin	ADV
ajst-23566	7	4	;	;	PUNCT
ajst-23566	7	5	mutagenesis	mutagenesis	NOUN
ajst-23566	7	6	;	;	PUNCT
ajst-23566	7	7	gene	gene	NOUN
ajst-23566	7	8	editing	editing	NOUN
ajst-23566	7	9	;	;	PUNCT
ajst-23566	7	10	current	current	ADJ
ajst-23566	7	11	status	status	NOUN
ajst-23566	7	12	of	of	ADP
ajst-23566	7	13	breeding	breeding	NOUN
ajst-23566	7	14	.	.	PUNCT
ajst-23566	8	1	1	1	X
ajst-23566	8	2	.	.	X
ajst-23566	8	3	introduction	introduction	NOUN
ajst-23566	8	4	avilamycin	avilamycin	ADV
ajst-23566	8	5	,	,	PUNCT
ajst-23566	8	6	commercially	commercially	ADV
ajst-23566	8	7	called	call	VERB
ajst-23566	8	8	peomycin	peomycin	NOUN
ajst-23566	8	9	,	,	PUNCT
ajst-23566	8	10	is	be	AUX
ajst-23566	8	11	one	one	NUM
ajst-23566	8	12	of	of	ADP
ajst-23566	8	13	the	the	DET
ajst-23566	8	14	important	important	ADJ
ajst-23566	8	15	antibiotics	antibiotic	NOUN
ajst-23566	8	16	produced	produce	VERB
ajst-23566	8	17	by	by	ADP
ajst-23566	8	18	the	the	DET
ajst-23566	8	19	ventilated	ventilate	VERB
ajst-23566	8	20	fermentation	fermentation	NOUN
ajst-23566	8	21	of	of	ADP
ajst-23566	8	22	streptomyces	streptomyce	NOUN
ajst-23566	8	23	viridochromogene	viridochromogene	NOUN
ajst-23566	8	24	.	.	PUNCT
ajst-23566	9	1	the	the	DET
ajst-23566	9	2	metabolite	metabolite	NOUN
ajst-23566	9	3	has	have	VERB
ajst-23566	9	4	a	a	DET
ajst-23566	9	5	substantial	substantial	ADJ
ajst-23566	9	6	contribution	contribution	NOUN
ajst-23566	9	7	to	to	ADP
ajst-23566	9	8	animal	animal	NOUN
ajst-23566	9	9	growth	growth	NOUN
ajst-23566	9	10	and	and	CCONJ
ajst-23566	9	11	metabolic	metabolic	NOUN
ajst-23566	9	12	regulation	regulation	NOUN
ajst-23566	9	13	.	.	PUNCT
ajst-23566	10	1	it	it	PRON
ajst-23566	10	2	predominantly	predominantly	ADV
ajst-23566	10	3	acts	act	VERB
ajst-23566	10	4	as	as	ADP
ajst-23566	10	5	an	an	DET
ajst-23566	10	6	inhibitor	inhibitor	NOUN
ajst-23566	10	7	of	of	ADP
ajst-23566	10	8	protein	protein	NOUN
ajst-23566	10	9	synthesis	synthesis	NOUN
ajst-23566	10	10	by	by	ADP
ajst-23566	10	11	gram	gram	NOUN
ajst-23566	10	12	-	-	PUNCT
ajst-23566	10	13	positive	positive	ADJ
ajst-23566	10	14	bacteria	bacteria	NOUN
ajst-23566	10	15	and	and	CCONJ
ajst-23566	10	16	regulates	regulate	VERB
ajst-23566	10	17	the	the	DET
ajst-23566	10	18	attack	attack	NOUN
ajst-23566	10	19	of	of	ADP
ajst-23566	10	20	bacterial	bacterial	ADJ
ajst-23566	10	21	infections	infection	NOUN
ajst-23566	10	22	in	in	ADP
ajst-23566	10	23	livestock	livestock	NOUN
ajst-23566	10	24	industries	industry	NOUN
ajst-23566	10	25	.	.	PUNCT
ajst-23566	11	1	as	as	SCONJ
ajst-23566	11	2	the	the	DET
ajst-23566	11	3	demand	demand	NOUN
ajst-23566	11	4	for	for	ADP
ajst-23566	11	5	meat	meat	NOUN
ajst-23566	11	6	and	and	CCONJ
ajst-23566	11	7	poultry	poultry	NOUN
ajst-23566	11	8	products	product	NOUN
ajst-23566	11	9	increases	increase	VERB
ajst-23566	11	10	worldwide	worldwide	ADV
ajst-23566	11	11	,	,	PUNCT
ajst-23566	11	12	so	so	ADV
ajst-23566	11	13	does	do	VERB
ajst-23566	11	14	the	the	DET
ajst-23566	11	15	demand	demand	NOUN
ajst-23566	11	16	for	for	ADP
ajst-23566	11	17	avilamycin	avilamycin	NOUN
ajst-23566	11	18	,	,	PUNCT
ajst-23566	11	19	resulting	result	VERB
ajst-23566	11	20	in	in	ADP
ajst-23566	11	21	an	an	DET
ajst-23566	11	22	increase	increase	NOUN
ajst-23566	11	23	in	in	ADP
ajst-23566	11	24	its	its	PRON
ajst-23566	11	25	market	market	NOUN
ajst-23566	11	26	value	value	NOUN
ajst-23566	11	27	and	and	CCONJ
ajst-23566	11	28	demand	demand	NOUN
ajst-23566	11	29	.	.	PUNCT
ajst-23566	12	1	this	this	DET
ajst-23566	12	2	increased	increase	VERB
ajst-23566	12	3	demand	demand	NOUN
ajst-23566	12	4	coupled	couple	VERB
ajst-23566	12	5	with	with	ADP
ajst-23566	12	6	limitation	limitation	NOUN
ajst-23566	12	7	in	in	ADP
ajst-23566	12	8	production	production	NOUN
ajst-23566	12	9	indicates	indicate	VERB
ajst-23566	12	10	the	the	DET
ajst-23566	12	11	need	need	NOUN
ajst-23566	12	12	for	for	ADP
ajst-23566	12	13	better	well	ADJ
ajst-23566	12	14	breeding	breeding	NOUN
ajst-23566	12	15	techniques	technique	NOUN
ajst-23566	12	16	in	in	ADP
ajst-23566	12	17	increasing	increase	VERB
ajst-23566	12	18	not	not	PART
ajst-23566	12	19	only	only	ADV
ajst-23566	12	20	the	the	DET
ajst-23566	12	21	yield	yield	NOUN
ajst-23566	12	22	but	but	CCONJ
ajst-23566	12	23	also	also	ADV
ajst-23566	12	24	the	the	DET
ajst-23566	12	25	quality	quality	NOUN
ajst-23566	12	26	of	of	ADP
ajst-23566	12	27	the	the	DET
ajst-23566	12	28	avilamycin	avilamycin	NOUN
ajst-23566	12	29	producing	produce	VERB
ajst-23566	12	30	bacteria	bacteria	NOUN
ajst-23566	12	31	.	.	PUNCT
ajst-23566	13	1	this	this	DET
ajst-23566	13	2	paper	paper	NOUN
ajst-23566	13	3	intends	intend	VERB
ajst-23566	13	4	to	to	PART
ajst-23566	13	5	delve	delve	VERB
ajst-23566	13	6	into	into	ADP
ajst-23566	13	7	the	the	DET
ajst-23566	13	8	current	current	ADJ
ajst-23566	13	9	methodologies	methodology	NOUN
ajst-23566	13	10	being	be	AUX
ajst-23566	13	11	applied	apply	VERB
ajst-23566	13	12	to	to	PART
ajst-23566	13	13	breed	breed	VERB
ajst-23566	13	14	these	these	DET
ajst-23566	13	15	bacteria	bacteria	NOUN
ajst-23566	13	16	,	,	PUNCT
ajst-23566	13	17	their	their	PRON
ajst-23566	13	18	physicochemical	physicochemical	ADJ
ajst-23566	13	19	attributes	attribute	NOUN
ajst-23566	13	20	,	,	PUNCT
ajst-23566	13	21	and	and	CCONJ
ajst-23566	13	22	further	far	ADV
ajst-23566	13	23	proposes	propose	VERB
ajst-23566	13	24	the	the	DET
ajst-23566	13	25	future	future	ADJ
ajst-23566	13	26	directions	direction	NOUN
ajst-23566	13	27	which	which	PRON
ajst-23566	13	28	can	can	AUX
ajst-23566	13	29	possibly	possibly	ADV
ajst-23566	13	30	lead	lead	VERB
ajst-23566	13	31	to	to	ADP
ajst-23566	13	32	upliftment	upliftment	NOUN
ajst-23566	13	33	in	in	ADP
ajst-23566	13	34	the	the	DET
ajst-23566	13	35	production	production	NOUN
ajst-23566	13	36	standards	standard	NOUN
ajst-23566	13	37	and	and	CCONJ
ajst-23566	13	38	meet	meet	VERB
ajst-23566	13	39	the	the	DET
ajst-23566	13	40	increased	increase	VERB
ajst-23566	13	41	market	market	NOUN
ajst-23566	13	42	requirements	requirement	NOUN
ajst-23566	13	43	.	.	PUNCT
ajst-23566	14	1	2	2	X
ajst-23566	14	2	.	.	X
ajst-23566	14	3	current	current	ADJ
ajst-23566	14	4	challenges	challenge	NOUN
ajst-23566	14	5	in	in	ADP
ajst-23566	14	6	avilamycin	avilamycin	NOUN
ajst-23566	14	7	production	production	NOUN
ajst-23566	14	8	this	this	PRON
ajst-23566	14	9	has	have	AUX
ajst-23566	14	10	further	far	ADV
ajst-23566	14	11	been	be	AUX
ajst-23566	14	12	spurred	spur	VERB
ajst-23566	14	13	by	by	ADP
ajst-23566	14	14	the	the	DET
ajst-23566	14	15	high	high	ADJ
ajst-23566	14	16	growth	growth	NOUN
ajst-23566	14	17	rates	rate	NOUN
ajst-23566	14	18	of	of	ADP
ajst-23566	14	19	the	the	DET
ajst-23566	14	20	livestock	livestock	NOUN
ajst-23566	14	21	and	and	CCONJ
ajst-23566	14	22	poultry	poultry	NOUN
ajst-23566	14	23	industries	industry	NOUN
ajst-23566	14	24	,	,	PUNCT
ajst-23566	14	25	which	which	PRON
ajst-23566	14	26	form	form	VERB
ajst-23566	14	27	the	the	DET
ajst-23566	14	28	primary	primary	ADJ
ajst-23566	14	29	market	market	NOUN
ajst-23566	14	30	for	for	ADP
ajst-23566	14	31	avilamycin	avilamycin	NOUN
ajst-23566	14	32	.	.	PUNCT
ajst-23566	15	1	the	the	DET
ajst-23566	15	2	more	more	ADV
ajst-23566	15	3	significant	significant	ADJ
ajst-23566	15	4	challenge	challenge	NOUN
ajst-23566	15	5	is	be	AUX
ajst-23566	15	6	from	from	ADP
ajst-23566	15	7	existing	exist	VERB
ajst-23566	15	8	production	production	NOUN
ajst-23566	15	9	capacities	capacity	NOUN
ajst-23566	15	10	,	,	PUNCT
ajst-23566	15	11	mostly	mostly	ADV
ajst-23566	15	12	falling	fall	VERB
ajst-23566	15	13	behind	behind	ADV
ajst-23566	15	14	.	.	PUNCT
ajst-23566	16	1	this	this	PRON
ajst-23566	16	2	is	be	AUX
ajst-23566	16	3	a	a	DET
ajst-23566	16	4	direct	direct	ADJ
ajst-23566	16	5	result	result	NOUN
ajst-23566	16	6	of	of	ADP
ajst-23566	16	7	the	the	DET
ajst-23566	16	8	twofold	twofold	ADJ
ajst-23566	16	9	nature	nature	NOUN
ajst-23566	16	10	of	of	ADP
ajst-23566	16	11	the	the	DET
ajst-23566	16	12	intricacies	intricacy	NOUN
ajst-23566	16	13	in	in	ADP
ajst-23566	16	14	avilamycin	avilamycin	PROPN
ajst-23566	16	15	production	production	NOUN
ajst-23566	16	16	:	:	PUNCT
ajst-23566	16	17	on	on	ADP
ajst-23566	16	18	one	one	NUM
ajst-23566	16	19	side	side	NOUN
ajst-23566	16	20	,	,	PUNCT
ajst-23566	16	21	the	the	DET
ajst-23566	16	22	existing	exist	VERB
ajst-23566	16	23	strains	strain	NOUN
ajst-23566	16	24	of	of	ADP
ajst-23566	16	25	streptomyces	streptomyce	NOUN
ajst-23566	16	26	viridochromogene	viridochromogene	NOUN
ajst-23566	16	27	will	will	AUX
ajst-23566	16	28	reach	reach	VERB
ajst-23566	16	29	their	their	PRON
ajst-23566	16	30	physical	physical	ADJ
ajst-23566	16	31	limitation	limitation	NOUN
ajst-23566	16	32	in	in	ADP
ajst-23566	16	33	volume	volume	NOUN
ajst-23566	16	34	;	;	PUNCT
ajst-23566	16	35	on	on	ADP
ajst-23566	16	36	the	the	DET
ajst-23566	16	37	other	other	ADJ
ajst-23566	16	38	,	,	PUNCT
ajst-23566	16	39	the	the	DET
ajst-23566	16	40	industrial	industrial	ADJ
ajst-23566	16	41	scaling	scaling	NOUN
ajst-23566	16	42	of	of	ADP
ajst-23566	16	43	the	the	DET
ajst-23566	16	44	production	production	NOUN
ajst-23566	16	45	processes	process	NOUN
ajst-23566	16	46	has	have	AUX
ajst-23566	16	47	stayed	stay	VERB
ajst-23566	16	48	slow	slow	ADJ
ajst-23566	16	49	and	and	CCONJ
ajst-23566	16	50	inefficient	inefficient	ADJ
ajst-23566	16	51	.	.	PUNCT
ajst-23566	17	1	these	these	PRON
ajst-23566	17	2	are	be	AUX
ajst-23566	17	3	further	far	ADV
ajst-23566	17	4	accentuated	accentuate	VERB
ajst-23566	17	5	by	by	ADP
ajst-23566	17	6	the	the	DET
ajst-23566	17	7	inherently	inherently	ADV
ajst-23566	17	8	specialized	specialized	ADJ
ajst-23566	17	9	nature	nature	NOUN
ajst-23566	17	10	of	of	ADP
ajst-23566	17	11	the	the	DET
ajst-23566	17	12	fermentation	fermentation	NOUN
ajst-23566	17	13	process	process	NOUN
ajst-23566	17	14	for	for	ADP
ajst-23566	17	15	avilamycin	avilamycin	NOUN
ajst-23566	17	16	that	that	PRON
ajst-23566	17	17	requires	require	VERB
ajst-23566	17	18	precise	precise	ADJ
ajst-23566	17	19	conditions	condition	NOUN
ajst-23566	17	20	to	to	PART
ajst-23566	17	21	provide	provide	VERB
ajst-23566	17	22	an	an	DET
ajst-23566	17	23	optimum	optimum	ADJ
ajst-23566	17	24	yield	yield	NOUN
ajst-23566	17	25	and	and	CCONJ
ajst-23566	17	26	activity	activity	NOUN
ajst-23566	17	27	.	.	PUNCT
ajst-23566	18	1	as	as	SCONJ
ajst-23566	18	2	would	would	AUX
ajst-23566	18	3	be	be	AUX
ajst-23566	18	4	anticipated	anticipate	VERB
ajst-23566	18	5	,	,	PUNCT
ajst-23566	18	6	the	the	DET
ajst-23566	18	7	prices	price	NOUN
ajst-23566	18	8	of	of	ADP
ajst-23566	18	9	avilamycin	avilamycin	NOUN
ajst-23566	18	10	have	have	AUX
ajst-23566	18	11	climbed	climb	VERB
ajst-23566	18	12	to	to	ADP
ajst-23566	18	13	peaks	peak	NOUN
ajst-23566	18	14	,	,	PUNCT
ajst-23566	18	15	attracting	attract	VERB
ajst-23566	18	16	high	high	ADJ
ajst-23566	18	17	scrutiny	scrutiny	NOUN
ajst-23566	18	18	toward	toward	ADP
ajst-23566	18	19	the	the	DET
ajst-23566	18	20	breeding	breeding	NOUN
ajst-23566	18	21	techniques	technique	NOUN
ajst-23566	18	22	that	that	PRON
ajst-23566	18	23	may	may	AUX
ajst-23566	18	24	possibly	possibly	ADV
ajst-23566	18	25	improve	improve	VERB
ajst-23566	18	26	the	the	DET
ajst-23566	18	27	production	production	NOUN
ajst-23566	18	28	efficiency	efficiency	NOUN
ajst-23566	18	29	.	.	PUNCT
ajst-23566	19	1	hence	hence	ADV
ajst-23566	19	2	,	,	PUNCT
ajst-23566	19	3	a	a	DET
ajst-23566	19	4	double	double	ADJ
ajst-23566	19	5	approach	approach	NOUN
ajst-23566	19	6	is	be	AUX
ajst-23566	19	7	needed	need	VERB
ajst-23566	19	8	:	:	PUNCT
ajst-23566	19	9	optimizing	optimize	VERB
ajst-23566	19	10	current	current	ADJ
ajst-23566	19	11	methodologies	methodology	NOUN
ajst-23566	19	12	but	but	CCONJ
ajst-23566	19	13	also	also	ADV
ajst-23566	19	14	including	include	VERB
ajst-23566	19	15	the	the	DET
ajst-23566	19	16	exploration	exploration	NOUN
ajst-23566	19	17	of	of	ADP
ajst-23566	19	18	new	new	ADJ
ajst-23566	19	19	biotechnological	biotechnological	ADJ
ajst-23566	19	20	advances	advance	NOUN
ajst-23566	19	21	to	to	PART
ajst-23566	19	22	effectively	effectively	ADV
ajst-23566	19	23	address	address	VERB
ajst-23566	19	24	market	market	NOUN
ajst-23566	19	25	demands	demand	NOUN
ajst-23566	19	26	.	.	PUNCT
ajst-23566	20	1	3	3	X
ajst-23566	20	2	.	.	X
ajst-23566	20	3	breeding	breed	VERB
ajst-23566	20	4	techniques	technique	NOUN
ajst-23566	20	5	for	for	ADP
ajst-23566	20	6	avilamycin	avilamycin	NOUN
ajst-23566	20	7	-	-	PUNCT
ajst-23566	20	8	producing	produce	VERB
ajst-23566	20	9	bacteria	bacteria	NOUN
ajst-23566	20	10	the	the	DET
ajst-23566	20	11	development	development	NOUN
ajst-23566	20	12	of	of	ADP
ajst-23566	20	13	avilamycin	avilamycin	NOUN
ajst-23566	20	14	-	-	PUNCT
ajst-23566	20	15	producing	produce	VERB
ajst-23566	20	16	bacteria	bacteria	NOUN
ajst-23566	20	17	depends	depend	VERB
ajst-23566	20	18	on	on	ADP
ajst-23566	20	19	a	a	DET
ajst-23566	20	20	combination	combination	NOUN
ajst-23566	20	21	of	of	ADP
ajst-23566	20	22	classic	classic	ADJ
ajst-23566	20	23	breeding	breeding	NOUN
ajst-23566	20	24	and	and	CCONJ
ajst-23566	20	25	modern	modern	ADJ
ajst-23566	20	26	genetic	genetic	ADJ
ajst-23566	20	27	engineering	engineering	NOUN
ajst-23566	20	28	.	.	PUNCT
ajst-23566	21	1	natural	natural	ADJ
ajst-23566	21	2	selection	selection	NOUN
ajst-23566	21	3	and	and	CCONJ
ajst-23566	21	4	induced	induced	ADJ
ajst-23566	21	5	mutation	mutation	NOUN
ajst-23566	21	6	are	be	AUX
ajst-23566	21	7	very	very	ADV
ajst-23566	21	8	important	important	ADJ
ajst-23566	21	9	at	at	ADP
ajst-23566	21	10	the	the	DET
ajst-23566	21	11	beginning	beginning	NOUN
ajst-23566	21	12	.	.	PUNCT
ajst-23566	22	1	the	the	DET
ajst-23566	22	2	first	first	ADJ
ajst-23566	22	3	one	one	NOUN
ajst-23566	22	4	is	be	AUX
ajst-23566	22	5	a	a	DET
ajst-23566	22	6	basic	basic	ADJ
ajst-23566	22	7	step	step	NOUN
ajst-23566	22	8	and	and	CCONJ
ajst-23566	22	9	very	very	ADV
ajst-23566	22	10	important	important	ADJ
ajst-23566	22	11	for	for	ADP
ajst-23566	22	12	the	the	DET
ajst-23566	22	13	primary	primary	ADJ
ajst-23566	22	14	avilamycin	avilamycin	NOUN
ajst-23566	22	15	production	production	NOUN
ajst-23566	22	16	improvement	improvement	NOUN
ajst-23566	22	17	.	.	PUNCT
ajst-23566	23	1	in	in	ADP
ajst-23566	23	2	the	the	DET
ajst-23566	23	3	first	first	ADJ
ajst-23566	23	4	step	step	NOUN
ajst-23566	23	5	,	,	PUNCT
ajst-23566	23	6	either	either	CCONJ
ajst-23566	23	7	high	high	ADV
ajst-23566	23	8	-	-	PUNCT
ajst-23566	23	9	yielding	yield	VERB
ajst-23566	23	10	strains	strain	NOUN
ajst-23566	23	11	are	be	AUX
ajst-23566	23	12	isolated	isolate	VERB
ajst-23566	23	13	from	from	ADP
ajst-23566	23	14	natural	natural	ADJ
ajst-23566	23	15	sources	source	NOUN
ajst-23566	23	16	or	or	CCONJ
ajst-23566	23	17	by	by	ADP
ajst-23566	23	18	treatment	treatment	NOUN
ajst-23566	23	19	with	with	ADP
ajst-23566	23	20	mutagenic	mutagenic	ADJ
ajst-23566	23	21	agents	agent	NOUN
ajst-23566	23	22	,	,	PUNCT
ajst-23566	23	23	such	such	ADJ
ajst-23566	23	24	as	as	ADP
ajst-23566	23	25	uv	uv	NOUN
ajst-23566	23	26	light	light	NOUN
ajst-23566	23	27	and	and	CCONJ
ajst-23566	23	28	chemical	chemical	NOUN
ajst-23566	23	29	mutagens	mutagen	NOUN
ajst-23566	23	30	.	.	PUNCT
ajst-23566	24	1	the	the	DET
ajst-23566	24	2	first	first	ADJ
ajst-23566	24	3	one	one	NOUN
ajst-23566	24	4	is	be	AUX
ajst-23566	24	5	a	a	DET
ajst-23566	24	6	basic	basic	ADJ
ajst-23566	24	7	step	step	NOUN
ajst-23566	24	8	and	and	CCONJ
ajst-23566	24	9	very	very	ADV
ajst-23566	24	10	important	important	ADJ
ajst-23566	24	11	for	for	ADP
ajst-23566	24	12	the	the	DET
ajst-23566	24	13	primary	primary	ADJ
ajst-23566	24	14	avilamycin	avilamycin	NOUN
ajst-23566	24	15	production	production	NOUN
ajst-23566	24	16	improvement	improvement	NOUN
ajst-23566	24	17	.	.	PUNCT
ajst-23566	25	1	the	the	DET
ajst-23566	25	2	first	first	ADJ
ajst-23566	25	3	one	one	NOUN
ajst-23566	25	4	is	be	AUX
ajst-23566	25	5	a	a	DET
ajst-23566	25	6	basic	basic	ADJ
ajst-23566	25	7	step	step	NOUN
ajst-23566	25	8	and	and	CCONJ
ajst-23566	25	9	very	very	ADV
ajst-23566	25	10	important	important	ADJ
ajst-23566	25	11	for	for	ADP
ajst-23566	25	12	the	the	DET
ajst-23566	25	13	primary	primary	ADJ
ajst-23566	25	14	avilamycin	avilamycin	NOUN
ajst-23566	25	15	production	production	NOUN
ajst-23566	25	16	improvement	improvement	NOUN
ajst-23566	25	17	.	.	PUNCT
ajst-23566	26	1	these	these	PRON
ajst-23566	26	2	are	be	AUX
ajst-23566	26	3	carried	carry	VERB
ajst-23566	26	4	out	out	ADP
ajst-23566	26	5	,	,	PUNCT
ajst-23566	26	6	in	in	ADP
ajst-23566	26	7	parallel	parallel	NOUN
ajst-23566	26	8	,	,	PUNCT
ajst-23566	26	9	with	with	ADP
ajst-23566	26	10	modern	modern	ADJ
ajst-23566	26	11	genetic	genetic	ADJ
ajst-23566	26	12	engineering	engineering	NOUN
ajst-23566	26	13	techniques	technique	NOUN
ajst-23566	26	14	that	that	PRON
ajst-23566	26	15	now	now	ADV
ajst-23566	26	16	offer	offer	VERB
ajst-23566	26	17	more	more	ADV
ajst-23566	26	18	precise	precise	ADJ
ajst-23566	26	19	and	and	CCONJ
ajst-23566	26	20	effective	effective	ADJ
ajst-23566	26	21	methodology	methodology	NOUN
ajst-23566	26	22	.	.	PUNCT
ajst-23566	27	1	the	the	DET
ajst-23566	27	2	adjustments	adjustment	NOUN
ajst-23566	27	3	are	be	AUX
ajst-23566	27	4	made	make	VERB
ajst-23566	27	5	to	to	ADP
ajst-23566	27	6	the	the	DET
ajst-23566	27	7	genetic	genetic	ADJ
ajst-23566	27	8	materials	material	NOUN
ajst-23566	27	9	of	of	ADP
ajst-23566	27	10	bacteria	bacteria	NOUN
ajst-23566	27	11	to	to	PART
ajst-23566	27	12	adapt	adapt	VERB
ajst-23566	27	13	metabolic	metabolic	NOUN
ajst-23566	27	14	pathways	pathway	NOUN
ajst-23566	27	15	directly	directly	ADV
ajst-23566	27	16	related	relate	VERB
ajst-23566	27	17	to	to	ADP
ajst-23566	27	18	avilamycin	avilamycin	VERB
ajst-23566	27	19	production	production	NOUN
ajst-23566	27	20	.	.	PUNCT
ajst-23566	28	1	last	last	ADJ
ajst-23566	28	2	but	but	CCONJ
ajst-23566	28	3	not	not	PART
ajst-23566	28	4	least	least	ADJ
ajst-23566	28	5	,	,	PUNCT
ajst-23566	28	6	the	the	DET
ajst-23566	28	7	central	central	ADJ
ajst-23566	28	8	tool	tool	NOUN
ajst-23566	28	9	in	in	ADP
ajst-23566	28	10	this	this	DET
ajst-23566	28	11	field	field	NOUN
ajst-23566	28	12	,	,	PUNCT
ajst-23566	28	13	crispr	crispr	NOUN
ajst-23566	28	14	-	-	PUNCT
ajst-23566	28	15	cas9	cas9	NOUN
ajst-23566	28	16	,	,	PUNCT
ajst-23566	28	17	enables	enable	VERB
ajst-23566	28	18	specific	specific	ADJ
ajst-23566	28	19	changes	change	NOUN
ajst-23566	28	20	in	in	ADP
ajst-23566	28	21	the	the	DET
ajst-23566	28	22	dna	dna	PROPN
ajst-23566	28	23	sequence	sequence	NOUN
ajst-23566	28	24	that	that	PRON
ajst-23566	28	25	might	might	AUX
ajst-23566	28	26	yield	yield	VERB
ajst-23566	28	27	an	an	DET
ajst-23566	28	28	increase	increase	NOUN
ajst-23566	28	29	at	at	ADP
ajst-23566	28	30	the	the	DET
ajst-23566	28	31	same	same	ADJ
ajst-23566	28	32	time	time	NOUN
ajst-23566	28	33	as	as	ADP
ajst-23566	28	34	robustness	robustness	NOUN
ajst-23566	28	35	toward	toward	ADP
ajst-23566	28	36	environmental	environmental	ADJ
ajst-23566	28	37	stresses	stress	NOUN
ajst-23566	28	38	.	.	PUNCT
ajst-23566	29	1	in	in	ADP
ajst-23566	29	2	addition	addition	NOUN
ajst-23566	29	3	,	,	PUNCT
ajst-23566	29	4	genomic	genomic	ADJ
ajst-23566	29	5	analysis	analysis	NOUN
ajst-23566	29	6	advanced	advance	VERB
ajst-23566	29	7	into	into	ADP
ajst-23566	29	8	play	play	NOUN
ajst-23566	29	9	.	.	PUNCT
ajst-23566	30	1	sequencing	sequence	VERB
ajst-23566	30	2	genomes	genome	NOUN
ajst-23566	30	3	of	of	ADP
ajst-23566	30	4	high	high	ADJ
ajst-23566	30	5	producing	produce	VERB
ajst-23566	30	6	strains	strain	NOUN
ajst-23566	30	7	will	will	AUX
ajst-23566	30	8	make	make	VERB
ajst-23566	30	9	it	it	PRON
ajst-23566	30	10	possible	possible	ADJ
ajst-23566	30	11	to	to	PART
ajst-23566	30	12	identify	identify	VERB
ajst-23566	30	13	the	the	DET
ajst-23566	30	14	crucial	crucial	ADJ
ajst-23566	30	15	genes	gene	NOUN
ajst-23566	30	16	involved	involve	VERB
ajst-23566	30	17	in	in	ADP
ajst-23566	30	18	the	the	DET
ajst-23566	30	19	biosynthesis	biosynthesis	NOUN
ajst-23566	30	20	of	of	ADP
ajst-23566	30	21	avilamycin	avilamycin	NOUN
ajst-23566	30	22	.	.	PUNCT
ajst-23566	31	1	manipulation	manipulation	NOUN
ajst-23566	31	2	of	of	ADP
ajst-23566	31	3	the	the	DET
ajst-23566	31	4	very	very	ADJ
ajst-23566	31	5	genes	gene	NOUN
ajst-23566	31	6	will	will	AUX
ajst-23566	31	7	result	result	VERB
ajst-23566	31	8	in	in	ADP
ajst-23566	31	9	a	a	DET
ajst-23566	31	10	more	more	ADV
ajst-23566	31	11	efficient	efficient	ADJ
ajst-23566	31	12	production	production	NOUN
ajst-23566	31	13	pathway	pathway	NOUN
ajst-23566	31	14	.	.	PUNCT
ajst-23566	32	1	for	for	ADP
ajst-23566	32	2	example	example	NOUN
ajst-23566	32	3	,	,	PUNCT
ajst-23566	32	4	genes	gene	NOUN
ajst-23566	32	5	that	that	PRON
ajst-23566	32	6	control	control	VERB
ajst-23566	32	7	the	the	DET
ajst-23566	32	8	supply	supply	NOUN
ajst-23566	32	9	of	of	ADP
ajst-23566	32	10	precursors	precursor	NOUN
ajst-23566	32	11	to	to	ADP
ajst-23566	32	12	the	the	DET
ajst-23566	32	13	avilamycin	avilamycin	NOUN
ajst-23566	32	14	biosynthesis	biosynthesis	NOUN
ajst-23566	32	15	pathway	pathway	NOUN
ajst-23566	32	16	need	need	VERB
ajst-23566	32	17	to	to	PART
ajst-23566	32	18	be	be	AUX
ajst-23566	32	19	overexpressed	overexpresse	VERB
ajst-23566	32	20	,	,	PUNCT
ajst-23566	32	21	repressed	repressed	ADJ
ajst-23566	32	22	,	,	PUNCT
ajst-23566	32	23	or	or	CCONJ
ajst-23566	32	24	conditionally	conditionally	ADV
ajst-23566	32	25	expressed	express	VERB
ajst-23566	32	26	,	,	PUNCT
ajst-23566	32	27	depending	depend	VERB
ajst-23566	32	28	on	on	ADP
ajst-23566	32	29	the	the	DET
ajst-23566	32	30	effect	effect	NOUN
ajst-23566	32	31	on	on	ADP
ajst-23566	32	32	yield	yield	NOUN
ajst-23566	32	33	and	and	CCONJ
ajst-23566	32	34	consistency	consistency	NOUN
ajst-23566	32	35	of	of	ADP
ajst-23566	32	36	product	product	NOUN
ajst-23566	32	37	.	.	PUNCT
ajst-23566	33	1	incorporating	incorporate	VERB
ajst-23566	33	2	such	such	ADJ
ajst-23566	33	3	biotechnological	biotechnological	ADJ
ajst-23566	33	4	tools	tool	NOUN
ajst-23566	33	5	into	into	ADP
ajst-23566	33	6	the	the	DET
ajst-23566	33	7	breeding	breeding	NOUN
ajst-23566	33	8	programs	program	NOUN
ajst-23566	33	9	reduces	reduce	VERB
ajst-23566	33	10	the	the	DET
ajst-23566	33	11	speed	speed	NOUN
ajst-23566	33	12	at	at	ADP
ajst-23566	33	13	which	which	PRON
ajst-23566	33	14	the	the	DET
ajst-23566	33	15	process	process	NOUN
ajst-23566	33	16	occurs	occur	VERB
ajst-23566	33	17	,	,	PUNCT
ajst-23566	33	18	while	while	SCONJ
ajst-23566	33	19	increasing	increase	VERB
ajst-23566	33	20	the	the	DET
ajst-23566	33	21	precision	precision	NOUN
ajst-23566	33	22	in	in	ADP
ajst-23566	33	23	which	which	PRON
ajst-23566	33	24	genetic	genetic	ADJ
ajst-23566	33	25	modifications	modification	NOUN
ajst-23566	33	26	can	can	AUX
ajst-23566	33	27	be	be	AUX
ajst-23566	33	28	implemented	implement	VERB
ajst-23566	33	29	.	.	PUNCT
ajst-23566	34	1	this	this	DET
ajst-23566	34	2	results	result	VERB
ajst-23566	34	3	in	in	ADP
ajst-23566	34	4	better	well	ADV
ajst-23566	34	5	-	-	PUNCT
ajst-23566	34	6	adapted	adapt	VERB
ajst-23566	34	7	strains	strain	NOUN
ajst-23566	34	8	for	for	ADP
ajst-23566	34	9	largescale	largescale	NOUN
ajst-23566	34	10	production	production	NOUN
ajst-23566	34	11	,	,	PUNCT
ajst-23566	34	12	meeting	meet	VERB
ajst-23566	34	13	the	the	DET
ajst-23566	34	14	increasing	increase	VERB
ajst-23566	34	15	demands	demand	NOUN
ajst-23566	34	16	of	of	ADP
ajst-23566	34	17	the	the	DET
ajst-23566	34	18	market	market	NOUN
ajst-23566	34	19	.	.	PUNCT
ajst-23566	35	1	in	in	ADP
ajst-23566	35	2	addition	addition	NOUN
ajst-23566	35	3	,	,	PUNCT
ajst-23566	35	4	these	these	DET
ajst-23566	35	5	techniques	technique	NOUN
ajst-23566	35	6	could	could	AUX
ajst-23566	35	7	contribute	contribute	VERB
ajst-23566	35	8	to	to	ADP
ajst-23566	35	9	sustainable	sustainable	ADJ
ajst-23566	35	10	production	production	NOUN
ajst-23566	35	11	by	by	ADP
ajst-23566	35	12	possibly	possibly	ADV
ajst-23566	35	13	reducing	reduce	VERB
ajst-23566	35	14	the	the	DET
ajst-23566	35	15	environmental	environmental	ADJ
ajst-23566	35	16	footprint	footprint	NOUN
ajst-23566	35	17	of	of	ADP
ajst-23566	35	18	the	the	DET
ajst-23566	35	19	manufacturing	manufacturing	NOUN
ajst-23566	35	20	process	process	NOUN
ajst-23566	35	21	.	.	PUNCT
ajst-23566	36	1	in	in	ADP
ajst-23566	36	2	essence	essence	NOUN
ajst-23566	36	3	,	,	PUNCT
ajst-23566	36	4	breeding	breeding	NOUN
ajst-23566	36	5	of	of	ADP
ajst-23566	36	6	the	the	DET
ajst-23566	36	7	avilamycin	avilamycin	NOUN
ajst-23566	36	8	-	-	PUNCT
ajst-23566	36	9	producing	produce	VERB
ajst-23566	36	10	bacteria	bacteria	NOUN
ajst-23566	36	11	has	have	AUX
ajst-23566	36	12	transformed	transform	VERB
ajst-23566	36	13	from	from	ADP
ajst-23566	36	14	the	the	DET
ajst-23566	36	15	conventional	conventional	ADJ
ajst-23566	36	16	method	method	NOUN
ajst-23566	36	17	to	to	ADP
ajst-23566	36	18	some	some	DET
ajst-23566	36	19	103	103	NUM
ajst-23566	36	20	sophisticated	sophisticated	ADJ
ajst-23566	36	21	genetic	genetic	ADJ
ajst-23566	36	22	manipulations	manipulation	NOUN
ajst-23566	36	23	,	,	PUNCT
ajst-23566	36	24	which	which	PRON
ajst-23566	36	25	have	have	AUX
ajst-23566	36	26	made	make	VERB
ajst-23566	36	27	a	a	DET
ajst-23566	36	28	vast	vast	ADJ
ajst-23566	36	29	step	step	NOUN
ajst-23566	36	30	for	for	ADP
ajst-23566	36	31	an	an	DET
ajst-23566	36	32	increase	increase	NOUN
ajst-23566	36	33	in	in	ADP
ajst-23566	36	34	both	both	PRON
ajst-23566	36	35	yield	yield	NOUN
ajst-23566	36	36	and	and	CCONJ
ajst-23566	36	37	quality	quality	NOUN
ajst-23566	36	38	of	of	ADP
ajst-23566	36	39	the	the	DET
ajst-23566	36	40	avilamycin	avilamycin	NOUN
ajst-23566	36	41	.	.	PUNCT
ajst-23566	37	1	4	4	X
ajst-23566	37	2	.	.	X
ajst-23566	37	3	advanced	advanced	ADJ
ajst-23566	37	4	breeding	breeding	NOUN
ajst-23566	37	5	techniques	technique	NOUN
ajst-23566	37	6	for	for	ADP
ajst-23566	37	7	avilamycin	avilamycin	NOUN
ajst-23566	37	8	production	production	NOUN
ajst-23566	37	9	these	these	DET
ajst-23566	37	10	modern	modern	ADJ
ajst-23566	37	11	methods	method	NOUN
ajst-23566	37	12	,	,	PUNCT
ajst-23566	37	13	such	such	ADJ
ajst-23566	37	14	as	as	ADP
ajst-23566	37	15	nitrogen	nitrogen	NOUN
ajst-23566	37	16	ion	ion	NOUN
ajst-23566	37	17	implantation	implantation	NOUN
ajst-23566	37	18	,	,	PUNCT
ajst-23566	37	19	will	will	AUX
ajst-23566	37	20	largely	largely	ADV
ajst-23566	37	21	improve	improve	VERB
ajst-23566	37	22	the	the	DET
ajst-23566	37	23	yield	yield	NOUN
ajst-23566	37	24	and	and	CCONJ
ajst-23566	37	25	resistance	resistance	NOUN
ajst-23566	37	26	of	of	ADP
ajst-23566	37	27	the	the	DET
ajst-23566	37	28	strain	strain	NOUN
ajst-23566	37	29	.	.	PUNCT
ajst-23566	38	1	the	the	DET
ajst-23566	38	2	usage	usage	NOUN
ajst-23566	38	3	of	of	ADP
ajst-23566	38	4	low	low	ADJ
ajst-23566	38	5	-	-	PUNCT
ajst-23566	38	6	energy	energy	NOUN
ajst-23566	38	7	nitrogen	nitrogen	NOUN
ajst-23566	38	8	ions	ion	NOUN
ajst-23566	38	9	in	in	ADP
ajst-23566	38	10	this	this	DET
ajst-23566	38	11	state	state	NOUN
ajst-23566	38	12	-	-	PUNCT
ajst-23566	38	13	of	of	ADP
ajst-23566	38	14	-	-	PUNCT
ajst-23566	38	15	the	the	DET
ajst-23566	38	16	-	-	PUNCT
ajst-23566	38	17	art	art	NOUN
ajst-23566	38	18	approach	approach	NOUN
ajst-23566	38	19	brings	bring	VERB
ajst-23566	38	20	some	some	DET
ajst-23566	38	21	very	very	ADV
ajst-23566	38	22	advantageous	advantageous	ADJ
ajst-23566	38	23	mutations	mutation	NOUN
ajst-23566	38	24	.	.	PUNCT
ajst-23566	39	1	they	they	PRON
ajst-23566	39	2	have	have	AUX
ajst-23566	39	3	effectively	effectively	ADV
ajst-23566	39	4	been	be	AUX
ajst-23566	39	5	demonstrated	demonstrate	VERB
ajst-23566	39	6	to	to	PART
ajst-23566	39	7	increase	increase	VERB
ajst-23566	39	8	the	the	DET
ajst-23566	39	9	resistance	resistance	NOUN
ajst-23566	39	10	of	of	ADP
ajst-23566	39	11	the	the	DET
ajst-23566	39	12	bacteria	bacteria	NOUN
ajst-23566	39	13	against	against	ADP
ajst-23566	39	14	competitive	competitive	ADJ
ajst-23566	39	15	antibiotics	antibiotic	NOUN
ajst-23566	39	16	,	,	PUNCT
ajst-23566	39	17	like	like	ADP
ajst-23566	39	18	streptomycin	streptomycin	PROPN
ajst-23566	39	19	,	,	PUNCT
ajst-23566	39	20	and	and	CCONJ
ajst-23566	39	21	yet	yet	ADV
ajst-23566	39	22	lead	lead	VERB
ajst-23566	39	23	to	to	ADP
ajst-23566	39	24	substantial	substantial	ADJ
ajst-23566	39	25	increases	increase	NOUN
ajst-23566	39	26	in	in	ADP
ajst-23566	39	27	avilamycin	avilamycin	NOUN
ajst-23566	39	28	production	production	NOUN
ajst-23566	39	29	.	.	PUNCT
ajst-23566	40	1	for	for	ADP
ajst-23566	40	2	example	example	NOUN
ajst-23566	40	3	,	,	PUNCT
ajst-23566	40	4	in	in	ADP
ajst-23566	40	5	these	these	DET
ajst-23566	40	6	experiments	experiment	NOUN
ajst-23566	40	7	,	,	PUNCT
ajst-23566	40	8	productivity	productivity	NOUN
ajst-23566	40	9	was	be	AUX
ajst-23566	40	10	increased	increase	VERB
ajst-23566	40	11	by	by	ADP
ajst-23566	40	12	195	195	NUM
ajst-23566	40	13	%	%	NOUN
ajst-23566	40	14	with	with	ADP
ajst-23566	40	15	the	the	DET
ajst-23566	40	16	created	create	VERB
ajst-23566	40	17	strains	strain	NOUN
ajst-23566	40	18	over	over	ADP
ajst-23566	40	19	the	the	DET
ajst-23566	40	20	original	original	ADJ
ajst-23566	40	21	strains	strain	NOUN
ajst-23566	40	22	.	.	PUNCT
ajst-23566	41	1	this	this	PRON
ajst-23566	41	2	is	be	AUX
ajst-23566	41	3	an	an	DET
ajst-23566	41	4	influential	influential	ADJ
ajst-23566	41	5	example	example	NOUN
ajst-23566	41	6	of	of	ADP
ajst-23566	41	7	how	how	SCONJ
ajst-23566	41	8	the	the	DET
ajst-23566	41	9	potential	potential	ADJ
ajst-23566	41	10	tool	tool	NOUN
ajst-23566	41	11	for	for	ADP
ajst-23566	41	12	increasing	increase	VERB
ajst-23566	41	13	yields	yield	NOUN
ajst-23566	41	14	of	of	ADP
ajst-23566	41	15	antibiotics	antibiotic	NOUN
ajst-23566	41	16	may	may	AUX
ajst-23566	41	17	be	be	AUX
ajst-23566	41	18	provided	provide	VERB
ajst-23566	41	19	by	by	ADP
ajst-23566	41	20	contemporary	contemporary	ADJ
ajst-23566	41	21	techniques	technique	NOUN
ajst-23566	41	22	of	of	ADP
ajst-23566	41	23	mutagenesis	mutagenesis	NOUN
ajst-23566	41	24	in	in	ADP
ajst-23566	41	25	microbial	microbial	ADJ
ajst-23566	41	26	breeding	breeding	NOUN
ajst-23566	41	27	.	.	PUNCT
ajst-23566	42	1	these	these	DET
ajst-23566	42	2	improvements	improvement	NOUN
ajst-23566	42	3	optimize	optimize	VERB
ajst-23566	42	4	the	the	DET
ajst-23566	42	5	characteristics	characteristic	NOUN
ajst-23566	42	6	of	of	ADP
ajst-23566	42	7	strains	strain	NOUN
ajst-23566	42	8	for	for	ADP
ajst-23566	42	9	better	well	ADJ
ajst-23566	42	10	productivity	productivity	NOUN
ajst-23566	42	11	and	and	CCONJ
ajst-23566	42	12	concurrently	concurrently	ADV
ajst-23566	42	13	boost	boost	VERB
ajst-23566	42	14	robustness	robustness	NOUN
ajst-23566	42	15	and	and	CCONJ
ajst-23566	42	16	efficiency	efficiency	NOUN
ajst-23566	42	17	of	of	ADP
ajst-23566	42	18	the	the	DET
ajst-23566	42	19	strains	strain	NOUN
ajst-23566	42	20	to	to	PART
ajst-23566	42	21	support	support	VERB
ajst-23566	42	22	scale	scale	NOUN
ajst-23566	42	23	-	-	PUNCT
ajst-23566	42	24	up	up	NOUN
ajst-23566	42	25	and	and	CCONJ
ajst-23566	42	26	sustainability	sustainability	NOUN
ajst-23566	42	27	of	of	ADP
ajst-23566	42	28	avilamycin	avilamycin	PROPN
ajst-23566	42	29	production	production	NOUN
ajst-23566	42	30	.	.	PUNCT
ajst-23566	43	1	5	5	X
ajst-23566	43	2	.	.	X
ajst-23566	43	3	role	role	NOUN
ajst-23566	43	4	of	of	ADP
ajst-23566	43	5	biotechnological	biotechnological	ADJ
ajst-23566	43	6	advances	advance	NOUN
ajst-23566	43	7	it	it	PRON
ajst-23566	43	8	follows	follow	VERB
ajst-23566	43	9	that	that	SCONJ
ajst-23566	43	10	recent	recent	ADJ
ajst-23566	43	11	special	special	ADJ
ajst-23566	43	12	attention	attention	NOUN
ajst-23566	43	13	is	be	AUX
ajst-23566	43	14	given	give	VERB
ajst-23566	43	15	to	to	ADP
ajst-23566	43	16	biotechnological	biotechnological	ADJ
ajst-23566	43	17	developments	development	NOUN
ajst-23566	43	18	associated	associate	VERB
ajst-23566	43	19	with	with	ADP
ajst-23566	43	20	the	the	DET
ajst-23566	43	21	breeding	breeding	NOUN
ajst-23566	43	22	of	of	ADP
ajst-23566	43	23	microbes	microbe	NOUN
ajst-23566	43	24	,	,	PUNCT
ajst-23566	43	25	and	and	CCONJ
ajst-23566	43	26	in	in	ADP
ajst-23566	43	27	particular	particular	ADJ
ajst-23566	43	28	,	,	PUNCT
ajst-23566	43	29	with	with	ADP
ajst-23566	43	30	increasing	increase	VERB
ajst-23566	43	31	avilamycin	avilamycin	PROPN
ajst-23566	43	32	production	production	NOUN
ajst-23566	43	33	.	.	PUNCT
ajst-23566	44	1	to	to	PART
ajst-23566	44	2	do	do	VERB
ajst-23566	44	3	so	so	ADV
ajst-23566	44	4	,	,	PUNCT
ajst-23566	44	5	more	more	ADV
ajst-23566	44	6	advanced	advanced	ADJ
ajst-23566	44	7	tools	tool	NOUN
ajst-23566	44	8	of	of	ADP
ajst-23566	44	9	genetic	genetic	ADJ
ajst-23566	44	10	engineering	engineering	NOUN
ajst-23566	44	11	,	,	PUNCT
ajst-23566	44	12	such	such	ADJ
ajst-23566	44	13	as	as	ADP
ajst-23566	44	14	gene	gene	NOUN
ajst-23566	44	15	editing	editing	NOUN
ajst-23566	44	16	tools	tool	NOUN
ajst-23566	44	17	like	like	ADP
ajst-23566	44	18	crispr	crispr	NOUN
ajst-23566	44	19	-	-	PUNCT
ajst-23566	44	20	cas9	cas9	NOUN
ajst-23566	44	21	,	,	PUNCT
ajst-23566	44	22	are	be	AUX
ajst-23566	44	23	harnessed	harness	VERB
ajst-23566	44	24	for	for	ADP
ajst-23566	44	25	highly	highly	ADV
ajst-23566	44	26	defined	define	VERB
ajst-23566	44	27	genetic	genetic	ADJ
ajst-23566	44	28	modifications	modification	NOUN
ajst-23566	44	29	of	of	ADP
ajst-23566	44	30	the	the	DET
ajst-23566	44	31	avilamycin	avilamycin	NOUN
ajst-23566	44	32	-	-	PUNCT
ajst-23566	44	33	producing	produce	VERB
ajst-23566	44	34	strain	strain	NOUN
ajst-23566	44	35	.	.	PUNCT
ajst-23566	45	1	such	such	ADJ
ajst-23566	45	2	tools	tool	NOUN
ajst-23566	45	3	allow	allow	VERB
ajst-23566	45	4	highly	highly	ADV
ajst-23566	45	5	directed	direct	VERB
ajst-23566	45	6	genetic	genetic	ADJ
ajst-23566	45	7	modifications	modification	NOUN
ajst-23566	45	8	of	of	ADP
ajst-23566	45	9	bacterial	bacterial	ADJ
ajst-23566	45	10	strains	strain	NOUN
ajst-23566	45	11	to	to	PART
ajst-23566	45	12	make	make	VERB
ajst-23566	45	13	them	they	PRON
ajst-23566	45	14	suitable	suitable	ADJ
ajst-23566	45	15	for	for	ADP
ajst-23566	45	16	high	high	ADJ
ajst-23566	45	17	avilamycin	avilamycin	NOUN
ajst-23566	45	18	production	production	NOUN
ajst-23566	45	19	while	while	SCONJ
ajst-23566	45	20	remaining	remain	VERB
ajst-23566	45	21	stable	stable	ADJ
ajst-23566	45	22	in	in	ADP
ajst-23566	45	23	the	the	DET
ajst-23566	45	24	long	long	ADJ
ajst-23566	45	25	run	run	NOUN
ajst-23566	45	26	under	under	ADP
ajst-23566	45	27	various	various	ADJ
ajst-23566	45	28	production	production	NOUN
ajst-23566	45	29	conditions	condition	NOUN
ajst-23566	45	30	.	.	PUNCT
ajst-23566	46	1	this	this	PRON
ajst-23566	46	2	has	have	AUX
ajst-23566	46	3	allowed	allow	VERB
ajst-23566	46	4	the	the	DET
ajst-23566	46	5	dna	dna	PROPN
ajst-23566	46	6	segments	segment	NOUN
ajst-23566	46	7	of	of	ADP
ajst-23566	46	8	the	the	DET
ajst-23566	46	9	microbial	microbial	ADJ
ajst-23566	46	10	genomes	genome	NOUN
ajst-23566	46	11	to	to	PART
ajst-23566	46	12	be	be	AUX
ajst-23566	46	13	modified	modify	VERB
ajst-23566	46	14	.	.	PUNCT
ajst-23566	47	1	therefore	therefore	ADV
ajst-23566	47	2	,	,	PUNCT
ajst-23566	47	3	the	the	DET
ajst-23566	47	4	genes	gene	NOUN
ajst-23566	47	5	that	that	PRON
ajst-23566	47	6	are	be	AUX
ajst-23566	47	7	directly	directly	ADV
ajst-23566	47	8	involved	involve	VERB
ajst-23566	47	9	in	in	ADP
ajst-23566	47	10	the	the	DET
ajst-23566	47	11	avilamycin	avilamycin	NOUN
ajst-23566	47	12	's	's	PART
ajst-23566	47	13	biosynthetic	biosynthetic	ADJ
ajst-23566	47	14	pathway	pathway	NOUN
ajst-23566	47	15	may	may	AUX
ajst-23566	47	16	be	be	AUX
ajst-23566	47	17	subjected	subject	VERB
ajst-23566	47	18	to	to	ADP
ajst-23566	47	19	further	further	ADJ
ajst-23566	47	20	modifications	modification	NOUN
ajst-23566	47	21	such	such	ADJ
ajst-23566	47	22	as	as	ADP
ajst-23566	47	23	genes	gene	NOUN
ajst-23566	47	24	that	that	PRON
ajst-23566	47	25	regulate	regulate	VERB
ajst-23566	47	26	the	the	DET
ajst-23566	47	27	supply	supply	NOUN
ajst-23566	47	28	of	of	ADP
ajst-23566	47	29	precursors	precursor	NOUN
ajst-23566	47	30	or	or	CCONJ
ajst-23566	47	31	the	the	DET
ajst-23566	47	32	expression	expression	NOUN
ajst-23566	47	33	of	of	ADP
ajst-23566	47	34	enzymes	enzyme	NOUN
ajst-23566	47	35	that	that	PRON
ajst-23566	47	36	are	be	AUX
ajst-23566	47	37	involved	involve	VERB
ajst-23566	47	38	in	in	ADP
ajst-23566	47	39	the	the	DET
ajst-23566	47	40	biosynthesis	biosynthesis	NOUN
ajst-23566	47	41	pathway	pathway	NOUN
ajst-23566	47	42	of	of	ADP
ajst-23566	47	43	the	the	DET
ajst-23566	47	44	antibiotic	antibiotic	NOUN
ajst-23566	47	45	.	.	PUNCT
ajst-23566	48	1	an	an	DET
ajst-23566	48	2	example	example	NOUN
ajst-23566	48	3	is	be	AUX
ajst-23566	48	4	the	the	DET
ajst-23566	48	5	increase	increase	NOUN
ajst-23566	48	6	in	in	ADP
ajst-23566	48	7	genes	gene	NOUN
ajst-23566	48	8	responsible	responsible	ADJ
ajst-23566	48	9	for	for	ADP
ajst-23566	48	10	the	the	DET
ajst-23566	48	11	metabolic	metabolic	NOUN
ajst-23566	48	12	flux	flux	NOUN
ajst-23566	48	13	toward	toward	ADP
ajst-23566	48	14	the	the	DET
ajst-23566	48	15	synthesis	synthesis	NOUN
ajst-23566	48	16	of	of	ADP
ajst-23566	48	17	avilamycin	avilamycin	NOUN
ajst-23566	48	18	,	,	PUNCT
ajst-23566	48	19	which	which	PRON
ajst-23566	48	20	in	in	ADP
ajst-23566	48	21	turn	turn	NOUN
ajst-23566	48	22	increases	increase	VERB
ajst-23566	48	23	efficiency	efficiency	NOUN
ajst-23566	48	24	in	in	ADP
ajst-23566	48	25	production	production	NOUN
ajst-23566	48	26	.	.	PUNCT
ajst-23566	49	1	the	the	DET
ajst-23566	49	2	silencing	silencing	NOUN
ajst-23566	49	3	of	of	ADP
ajst-23566	49	4	such	such	ADJ
ajst-23566	49	5	genes	gene	NOUN
ajst-23566	49	6	is	be	AUX
ajst-23566	49	7	directed	direct	VERB
ajst-23566	49	8	toward	toward	ADP
ajst-23566	49	9	the	the	DET
ajst-23566	49	10	formation	formation	NOUN
ajst-23566	49	11	of	of	ADP
ajst-23566	49	12	the	the	DET
ajst-23566	49	13	by	by	NOUN
ajst-23566	49	14	-	-	PUNCT
ajst-23566	49	15	product	product	NOUN
ajst-23566	49	16	,	,	PUNCT
ajst-23566	49	17	therefore	therefore	ADV
ajst-23566	49	18	increasing	increase	VERB
ajst-23566	49	19	the	the	DET
ajst-23566	49	20	purity	purity	NOUN
ajst-23566	49	21	of	of	ADP
ajst-23566	49	22	the	the	DET
ajst-23566	49	23	final	final	ADJ
ajst-23566	49	24	product	product	NOUN
ajst-23566	49	25	.	.	PUNCT
ajst-23566	50	1	apart	apart	ADV
ajst-23566	50	2	from	from	ADP
ajst-23566	50	3	that	that	PRON
ajst-23566	50	4	,	,	PUNCT
ajst-23566	50	5	genomic	genomic	ADJ
ajst-23566	50	6	analysis	analysis	NOUN
ajst-23566	50	7	technologies	technology	NOUN
ajst-23566	50	8	have	have	AUX
ajst-23566	50	9	also	also	ADV
ajst-23566	50	10	become	become	VERB
ajst-23566	50	11	indispensable	indispensable	ADJ
ajst-23566	50	12	.	.	PUNCT
ajst-23566	51	1	with	with	ADP
ajst-23566	51	2	the	the	DET
ajst-23566	51	3	help	help	NOUN
ajst-23566	51	4	of	of	ADP
ajst-23566	51	5	this	this	DET
ajst-23566	51	6	kit	kit	NOUN
ajst-23566	51	7	,	,	PUNCT
ajst-23566	51	8	researchers	researcher	NOUN
ajst-23566	51	9	are	be	AUX
ajst-23566	51	10	able	able	ADJ
ajst-23566	51	11	to	to	PART
ajst-23566	51	12	map	map	VERB
ajst-23566	51	13	the	the	DET
ajst-23566	51	14	entire	entire	ADJ
ajst-23566	51	15	genome	genome	NOUN
ajst-23566	51	16	of	of	ADP
ajst-23566	51	17	avilamycin	avilamycin	NOUN
ajst-23566	51	18	-	-	PUNCT
ajst-23566	51	19	producing	produce	VERB
ajst-23566	51	20	strains	strain	NOUN
ajst-23566	51	21	to	to	PART
ajst-23566	51	22	be	be	AUX
ajst-23566	51	23	able	able	ADJ
ajst-23566	51	24	to	to	PART
ajst-23566	51	25	decipher	decipher	VERB
ajst-23566	51	26	the	the	DET
ajst-23566	51	27	genetic	genetic	ADJ
ajst-23566	51	28	elements	element	NOUN
ajst-23566	51	29	and	and	CCONJ
ajst-23566	51	30	regulatory	regulatory	ADJ
ajst-23566	51	31	networks	network	NOUN
ajst-23566	51	32	that	that	PRON
ajst-23566	51	33	are	be	AUX
ajst-23566	51	34	very	very	ADV
ajst-23566	51	35	vital	vital	ADJ
ajst-23566	51	36	in	in	ADP
ajst-23566	51	37	controlling	control	VERB
ajst-23566	51	38	its	its	PRON
ajst-23566	51	39	production	production	NOUN
ajst-23566	51	40	.	.	PUNCT
ajst-23566	52	1	this	this	DET
ajst-23566	52	2	intensive	intensive	ADJ
ajst-23566	52	3	analysis	analysis	NOUN
ajst-23566	52	4	is	be	AUX
ajst-23566	52	5	necessary	necessary	ADJ
ajst-23566	52	6	for	for	ADP
ajst-23566	52	7	the	the	DET
ajst-23566	52	8	design	design	NOUN
ajst-23566	52	9	of	of	ADP
ajst-23566	52	10	an	an	DET
ajst-23566	52	11	optimized	optimize	VERB
ajst-23566	52	12	strain	strain	NOUN
ajst-23566	52	13	through	through	ADP
ajst-23566	52	14	synthetic	synthetic	ADJ
ajst-23566	52	15	biology	biology	NOUN
ajst-23566	52	16	methods	method	NOUN
ajst-23566	52	17	,	,	PUNCT
ajst-23566	52	18	a	a	DET
ajst-23566	52	19	prime	prime	ADJ
ajst-23566	52	20	example	example	NOUN
ajst-23566	52	21	where	where	SCONJ
ajst-23566	52	22	multiple	multiple	ADJ
ajst-23566	52	23	genetic	genetic	ADJ
ajst-23566	52	24	modifications	modification	NOUN
ajst-23566	52	25	are	be	AUX
ajst-23566	52	26	affected	affect	VERB
ajst-23566	52	27	to	to	PART
ajst-23566	52	28	rewire	rewire	VERB
ajst-23566	52	29	the	the	DET
ajst-23566	52	30	bacteria	bacteria	NOUN
ajst-23566	52	31	's	's	PART
ajst-23566	52	32	metabolite	metabolite	NOUN
ajst-23566	52	33	production	production	NOUN
ajst-23566	52	34	to	to	ADP
ajst-23566	52	35	desired	desire	VERB
ajst-23566	52	36	outputs	output	NOUN
ajst-23566	52	37	.	.	PUNCT
ajst-23566	53	1	such	such	ADJ
ajst-23566	53	2	advances	advance	NOUN
ajst-23566	53	3	in	in	ADP
ajst-23566	53	4	biotechnology	biotechnology	NOUN
ajst-23566	53	5	also	also	ADV
ajst-23566	53	6	greatly	greatly	ADV
ajst-23566	53	7	help	help	VERB
ajst-23566	53	8	with	with	ADP
ajst-23566	53	9	metabolic	metabolic	NOUN
ajst-23566	53	10	engineering	engineering	NOUN
ajst-23566	53	11	.	.	PUNCT
ajst-23566	54	1	metabolic	metabolic	NOUN
ajst-23566	54	2	engineering	engineering	NOUN
ajst-23566	54	3	can	can	AUX
ajst-23566	54	4	be	be	AUX
ajst-23566	54	5	defined	define	VERB
ajst-23566	54	6	as	as	ADP
ajst-23566	54	7	the	the	DET
ajst-23566	54	8	re	re	NOUN
ajst-23566	54	9	-	-	NOUN
ajst-23566	54	10	engineering	engineering	NOUN
ajst-23566	54	11	of	of	ADP
ajst-23566	54	12	metabolic	metabolic	NOUN
ajst-23566	54	13	pathways	pathway	NOUN
ajst-23566	54	14	to	to	PART
ajst-23566	54	15	increase	increase	VERB
ajst-23566	54	16	precursor	precursor	NOUN
ajst-23566	54	17	flow	flow	NOUN
ajst-23566	54	18	into	into	ADP
ajst-23566	54	19	the	the	DET
ajst-23566	54	20	desired	desire	VERB
ajst-23566	54	21	product	product	NOUN
ajst-23566	54	22	.	.	PUNCT
ajst-23566	55	1	this	this	PRON
ajst-23566	55	2	can	can	AUX
ajst-23566	55	3	be	be	AUX
ajst-23566	55	4	achieved	achieve	VERB
ajst-23566	55	5	through	through	ADP
ajst-23566	55	6	techniques	technique	NOUN
ajst-23566	55	7	such	such	ADJ
ajst-23566	55	8	as	as	ADP
ajst-23566	55	9	metabolic	metabolic	NOUN
ajst-23566	55	10	flux	flux	NOUN
ajst-23566	55	11	analysis	analysis	NOUN
ajst-23566	55	12	,	,	PUNCT
ajst-23566	55	13	for	for	ADP
ajst-23566	55	14	example	example	NOUN
ajst-23566	55	15	.	.	PUNCT
ajst-23566	56	1	a	a	DET
ajst-23566	56	2	metabolic	metabolic	NOUN
ajst-23566	56	3	flux	flux	NOUN
ajst-23566	56	4	analysis	analysis	NOUN
ajst-23566	56	5	helps	help	VERB
ajst-23566	56	6	to	to	PART
ajst-23566	56	7	pinpoint	pinpoint	VERB
ajst-23566	56	8	bottlenecks	bottleneck	NOUN
ajst-23566	56	9	in	in	ADP
ajst-23566	56	10	avilamycin	avilamycin	PROPN
ajst-23566	56	11	's	's	PART
ajst-23566	56	12	biosynthetic	biosynthetic	ADJ
ajst-23566	56	13	pathways	pathway	NOUN
ajst-23566	56	14	.	.	PUNCT
ajst-23566	57	1	genetic	genetic	ADJ
ajst-23566	57	2	engineering	engineering	NOUN
ajst-23566	57	3	will	will	AUX
ajst-23566	57	4	then	then	ADV
ajst-23566	57	5	be	be	AUX
ajst-23566	57	6	able	able	ADJ
ajst-23566	57	7	to	to	PART
ajst-23566	57	8	remove	remove	VERB
ajst-23566	57	9	these	these	PRON
ajst-23566	57	10	.	.	PUNCT
ajst-23566	58	1	application	application	NOUN
ajst-23566	58	2	of	of	ADP
ajst-23566	58	3	such	such	ADJ
ajst-23566	58	4	biotechnological	biotechnological	ADJ
ajst-23566	58	5	advances	advance	NOUN
ajst-23566	58	6	accelerates	accelerate	VERB
ajst-23566	58	7	the	the	DET
ajst-23566	58	8	process	process	NOUN
ajst-23566	58	9	of	of	ADP
ajst-23566	58	10	breeding	breeding	NOUN
ajst-23566	58	11	and	and	CCONJ
ajst-23566	58	12	enhances	enhance	VERB
ajst-23566	58	13	precision	precision	NOUN
ajst-23566	58	14	for	for	ADP
ajst-23566	58	15	such	such	ADJ
ajst-23566	58	16	modifications	modification	NOUN
ajst-23566	58	17	,	,	PUNCT
ajst-23566	58	18	which	which	PRON
ajst-23566	58	19	make	make	VERB
ajst-23566	58	20	these	these	DET
ajst-23566	58	21	strains	strain	NOUN
ajst-23566	58	22	more	more	ADV
ajst-23566	58	23	adaptable	adaptable	ADJ
ajst-23566	58	24	to	to	ADP
ajst-23566	58	25	the	the	DET
ajst-23566	58	26	requirements	requirement	NOUN
ajst-23566	58	27	of	of	ADP
ajst-23566	58	28	industrial	industrial	ADJ
ajst-23566	58	29	-	-	PUNCT
ajst-23566	58	30	scale	scale	NOUN
ajst-23566	58	31	production	production	NOUN
ajst-23566	58	32	.	.	PUNCT
ajst-23566	59	1	therefore	therefore	ADV
ajst-23566	59	2	,	,	PUNCT
ajst-23566	59	3	precision	precision	NOUN
ajst-23566	59	4	breeding	breeding	NOUN
ajst-23566	59	5	is	be	AUX
ajst-23566	59	6	of	of	ADP
ajst-23566	59	7	key	key	ADJ
ajst-23566	59	8	importance	importance	NOUN
ajst-23566	59	9	for	for	ADP
ajst-23566	59	10	accommodating	accommodate	VERB
ajst-23566	59	11	the	the	DET
ajst-23566	59	12	increasing	increase	VERB
ajst-23566	59	13	global	global	ADJ
ajst-23566	59	14	demand	demand	NOUN
ajst-23566	59	15	for	for	ADP
ajst-23566	59	16	avilamycin	avilamycin	NOUN
ajst-23566	59	17	with	with	ADP
ajst-23566	59	18	simultaneously	simultaneously	ADV
ajst-23566	59	19	maintaining	maintain	VERB
ajst-23566	59	20	the	the	DET
ajst-23566	59	21	efficacy	efficacy	NOUN
ajst-23566	59	22	and	and	CCONJ
ajst-23566	59	23	safety	safety	NOUN
ajst-23566	59	24	standards	standard	NOUN
ajst-23566	59	25	.	.	PUNCT
ajst-23566	60	1	in	in	ADP
ajst-23566	60	2	conclusion	conclusion	NOUN
ajst-23566	60	3	,	,	PUNCT
ajst-23566	60	4	biotechnological	biotechnological	ADJ
ajst-23566	60	5	advancements	advancement	NOUN
ajst-23566	60	6	have	have	AUX
ajst-23566	60	7	found	find	VERB
ajst-23566	60	8	application	application	NOUN
ajst-23566	60	9	in	in	ADP
ajst-23566	60	10	the	the	DET
ajst-23566	60	11	breeding	breeding	NOUN
ajst-23566	60	12	of	of	ADP
ajst-23566	60	13	the	the	DET
ajst-23566	60	14	avilamycin	avilamycin	NOUN
ajst-23566	60	15	-	-	PUNCT
ajst-23566	60	16	producing	produce	VERB
ajst-23566	60	17	bacteria	bacteria	NOUN
ajst-23566	60	18	,	,	PUNCT
ajst-23566	60	19	and	and	CCONJ
ajst-23566	60	20	in	in	ADP
ajst-23566	60	21	this	this	DET
ajst-23566	60	22	instance	instance	NOUN
ajst-23566	60	23	,	,	PUNCT
ajst-23566	60	24	they	they	PRON
ajst-23566	60	25	provide	provide	VERB
ajst-23566	60	26	a	a	DET
ajst-23566	60	27	big	big	ADJ
ajst-23566	60	28	lesson	lesson	NOUN
ajst-23566	60	29	that	that	SCONJ
ajst-23566	60	30	the	the	DET
ajst-23566	60	31	future	future	NOUN
ajst-23566	60	32	needs	need	VERB
ajst-23566	60	33	to	to	PART
ajst-23566	60	34	be	be	AUX
ajst-23566	60	35	oriented	orient	VERB
ajst-23566	60	36	toward	toward	ADP
ajst-23566	60	37	production	production	NOUN
ajst-23566	60	38	processes	process	NOUN
ajst-23566	60	39	that	that	PRON
ajst-23566	60	40	are	be	AUX
ajst-23566	60	41	more	more	ADV
ajst-23566	60	42	efficient	efficient	ADJ
ajst-23566	60	43	,	,	PUNCT
ajst-23566	60	44	sustainable	sustainable	ADJ
ajst-23566	60	45	,	,	PUNCT
ajst-23566	60	46	and	and	CCONJ
ajst-23566	60	47	high	high	ADV
ajst-23566	60	48	-	-	PUNCT
ajst-23566	60	49	yielding	yielding	NOUN
ajst-23566	60	50	.	.	PUNCT
ajst-23566	61	1	the	the	DET
ajst-23566	61	2	developed	develop	VERB
ajst-23566	61	3	technologies	technology	NOUN
ajst-23566	61	4	increase	increase	VERB
ajst-23566	61	5	not	not	PART
ajst-23566	61	6	only	only	ADV
ajst-23566	61	7	the	the	DET
ajst-23566	61	8	potential	potential	NOUN
ajst-23566	61	9	of	of	ADP
ajst-23566	61	10	existing	exist	VERB
ajst-23566	61	11	strains	strain	NOUN
ajst-23566	61	12	but	but	CCONJ
ajst-23566	61	13	also	also	ADV
ajst-23566	61	14	create	create	VERB
ajst-23566	61	15	possibilities	possibility	NOUN
ajst-23566	61	16	for	for	ADP
ajst-23566	61	17	the	the	DET
ajst-23566	61	18	determination	determination	NOUN
ajst-23566	61	19	and	and	CCONJ
ajst-23566	61	20	commercial	commercial	ADJ
ajst-23566	61	21	application	application	NOUN
ajst-23566	61	22	of	of	ADP
ajst-23566	61	23	the	the	DET
ajst-23566	61	24	new	new	ADJ
ajst-23566	61	25	ones	one	NOUN
ajst-23566	61	26	,	,	PUNCT
ajst-23566	61	27	thus	thus	ADV
ajst-23566	61	28	increasing	increase	VERB
ajst-23566	61	29	strength	strength	NOUN
ajst-23566	61	30	and	and	CCONJ
ajst-23566	61	31	sustainability	sustainability	NOUN
ajst-23566	61	32	of	of	ADP
ajst-23566	61	33	avilamycin	avilamycin	PROPN
ajst-23566	61	34	production	production	NOUN
ajst-23566	61	35	.	.	PUNCT
ajst-23566	62	1	6	6	NUM
ajst-23566	62	2	.	.	X
ajst-23566	62	3	case	case	NOUN
ajst-23566	62	4	studies	study	NOUN
ajst-23566	62	5	and	and	CCONJ
ajst-23566	62	6	research	research	NOUN
ajst-23566	62	7	highlights	highlight	NOUN
ajst-23566	62	8	this	this	DET
ajst-23566	62	9	section	section	NOUN
ajst-23566	62	10	critically	critically	ADV
ajst-23566	62	11	reviews	review	VERB
ajst-23566	62	12	important	important	ADJ
ajst-23566	62	13	areas	area	NOUN
ajst-23566	62	14	of	of	ADP
ajst-23566	62	15	research	research	NOUN
ajst-23566	62	16	and	and	CCONJ
ajst-23566	62	17	technological	technological	ADJ
ajst-23566	62	18	advances	advance	NOUN
ajst-23566	62	19	that	that	PRON
ajst-23566	62	20	have	have	AUX
ajst-23566	62	21	significantly	significantly	ADV
ajst-23566	62	22	influenced	influence	VERB
ajst-23566	62	23	the	the	DET
ajst-23566	62	24	breeding	breeding	NOUN
ajst-23566	62	25	of	of	ADP
ajst-23566	62	26	avilamycin	avilamycin	NOUN
ajst-23566	62	27	-	-	PUNCT
ajst-23566	62	28	producing	produce	VERB
ajst-23566	62	29	bacteria	bacteria	NOUN
ajst-23566	62	30	,	,	PUNCT
ajst-23566	62	31	drawing	draw	VERB
ajst-23566	62	32	on	on	ADP
ajst-23566	62	33	various	various	ADJ
ajst-23566	62	34	studies	study	NOUN
ajst-23566	62	35	from	from	ADP
ajst-23566	62	36	genetic	genetic	ADJ
ajst-23566	62	37	selection	selection	NOUN
ajst-23566	62	38	to	to	ADP
ajst-23566	62	39	advanced	advanced	ADJ
ajst-23566	62	40	mutagenesis	mutagenesis	NOUN
ajst-23566	62	41	techniques	technique	NOUN
ajst-23566	62	42	.	.	PUNCT
ajst-23566	63	1	(	(	PUNCT
ajst-23566	63	2	1	1	X
ajst-23566	63	3	)	)	PUNCT
ajst-23566	63	4	selection	selection	NOUN
ajst-23566	63	5	and	and	CCONJ
ajst-23566	63	6	development	development	NOUN
ajst-23566	63	7	of	of	ADP
ajst-23566	63	8	high	high	ADV
ajst-23566	63	9	-	-	PUNCT
ajst-23566	63	10	yielding	yield	VERB
ajst-23566	63	11	strains	strain	NOUN
ajst-23566	63	12	:	:	PUNCT
ajst-23566	63	13	professor	professor	NOUN
ajst-23566	63	14	zhao	zhao	PROPN
ajst-23566	63	15	focused	focus	VERB
ajst-23566	63	16	on	on	ADP
ajst-23566	63	17	the	the	DET
ajst-23566	63	18	identification	identification	NOUN
ajst-23566	63	19	and	and	CCONJ
ajst-23566	63	20	development	development	NOUN
ajst-23566	63	21	of	of	ADP
ajst-23566	63	22	high	high	ADV
ajst-23566	63	23	-	-	PUNCT
ajst-23566	63	24	yielding	yield	VERB
ajst-23566	63	25	strains	strain	NOUN
ajst-23566	63	26	using	use	VERB
ajst-23566	63	27	traditional	traditional	ADJ
ajst-23566	63	28	selection	selection	NOUN
ajst-23566	63	29	techniques	technique	NOUN
ajst-23566	63	30	,	,	PUNCT
ajst-23566	63	31	providing	provide	VERB
ajst-23566	63	32	a	a	DET
ajst-23566	63	33	strong	strong	ADJ
ajst-23566	63	34	foundation	foundation	NOUN
ajst-23566	63	35	for	for	ADP
ajst-23566	63	36	future	future	ADJ
ajst-23566	63	37	genetic	genetic	ADJ
ajst-23566	63	38	research	research	NOUN
ajst-23566	64	1	[	[	X
ajst-23566	64	2	1	1	NUM
ajst-23566	64	3	]	]	PUNCT
ajst-23566	64	4	.	.	PUNCT
ajst-23566	65	1	professor	professor	PROPN
ajst-23566	65	2	zhu	zhu	PROPN
ajst-23566	65	3	further	far	ADV
ajst-23566	65	4	demonstrated	demonstrate	VERB
ajst-23566	65	5	the	the	DET
ajst-23566	65	6	application	application	NOUN
ajst-23566	65	7	of	of	ADP
ajst-23566	65	8	inferential	inferential	ADJ
ajst-23566	65	9	statistics	statistic	NOUN
ajst-23566	65	10	in	in	ADP
ajst-23566	65	11	selecting	select	VERB
ajst-23566	65	12	high	high	ADV
ajst-23566	65	13	-	-	PUNCT
ajst-23566	65	14	yielding	yield	VERB
ajst-23566	65	15	strains	strain	NOUN
ajst-23566	65	16	,	,	PUNCT
ajst-23566	65	17	showcasing	showcase	VERB
ajst-23566	65	18	the	the	DET
ajst-23566	65	19	integration	integration	NOUN
ajst-23566	65	20	of	of	ADP
ajst-23566	65	21	traditional	traditional	ADJ
ajst-23566	65	22	and	and	CCONJ
ajst-23566	65	23	modern	modern	ADJ
ajst-23566	65	24	statistical	statistical	ADJ
ajst-23566	65	25	methods	method	NOUN
ajst-23566	65	26	in	in	ADP
ajst-23566	65	27	strain	strain	ADJ
ajst-23566	65	28	improvement	improvement	NOUN
ajst-23566	65	29	[	[	X
ajst-23566	65	30	2	2	NUM
ajst-23566	65	31	]	]	PUNCT
ajst-23566	65	32	.	.	PUNCT
ajst-23566	66	1	(	(	PUNCT
ajst-23566	66	2	2	2	X
ajst-23566	66	3	)	)	PUNCT
ajst-23566	66	4	genetic	genetic	ADJ
ajst-23566	66	5	engineering	engineering	NOUN
ajst-23566	66	6	and	and	CCONJ
ajst-23566	66	7	biosynthetic	biosynthetic	ADJ
ajst-23566	66	8	pathway	pathway	NOUN
ajst-23566	66	9	analysis	analysis	NOUN
ajst-23566	66	10	:	:	PUNCT
ajst-23566	66	11	significant	significant	ADJ
ajst-23566	66	12	advances	advance	NOUN
ajst-23566	66	13	in	in	ADP
ajst-23566	66	14	synthetic	synthetic	ADJ
ajst-23566	66	15	biology	biology	NOUN
ajst-23566	66	16	were	be	AUX
ajst-23566	66	17	highlighted	highlight	VERB
ajst-23566	66	18	by	by	ADP
ajst-23566	66	19	professor	professor	NOUN
ajst-23566	66	20	gaisser	gaisser	PROPN
ajst-23566	66	21	and	and	CCONJ
ajst-23566	66	22	professor	professor	PROPN
ajst-23566	66	23	weitnauer	weitnauer	PROPN
ajst-23566	66	24	,	,	PUNCT
ajst-23566	66	25	who	who	PRON
ajst-23566	66	26	studied	study	VERB
ajst-23566	66	27	the	the	DET
ajst-23566	66	28	avilamycin	avilamycin	ADJ
ajst-23566	66	29	biosynthetic	biosynthetic	ADJ
ajst-23566	66	30	gene	gene	NOUN
ajst-23566	66	31	cluster	cluster	NOUN
ajst-23566	66	32	from	from	ADP
ajst-23566	66	33	streptomyces	streptomyce	NOUN
ajst-23566	66	34	.	.	PUNCT
ajst-23566	67	1	their	their	PRON
ajst-23566	67	2	work	work	NOUN
ajst-23566	67	3	on	on	ADP
ajst-23566	67	4	cloning	cloning	NOUN
ajst-23566	67	5	and	and	CCONJ
ajst-23566	67	6	molecular	molecular	ADJ
ajst-23566	67	7	analysis	analysis	NOUN
ajst-23566	67	8	offers	offer	VERB
ajst-23566	67	9	deep	deep	ADJ
ajst-23566	67	10	insights	insight	NOUN
ajst-23566	67	11	into	into	ADP
ajst-23566	67	12	the	the	DET
ajst-23566	67	13	genetic	genetic	ADJ
ajst-23566	67	14	underpinnings	underpinning	NOUN
ajst-23566	67	15	of	of	ADP
ajst-23566	67	16	antibiotic	antibiotic	ADJ
ajst-23566	67	17	production	production	NOUN
ajst-23566	67	18	and	and	CCONJ
ajst-23566	67	19	points	point	NOUN
ajst-23566	67	20	towards	towards	ADP
ajst-23566	67	21	future	future	ADJ
ajst-23566	67	22	opportunities	opportunity	NOUN
ajst-23566	67	23	in	in	ADP
ajst-23566	67	24	synthetic	synthetic	ADJ
ajst-23566	67	25	biology	biology	NOUN
ajst-23566	67	26	[	[	X
ajst-23566	67	27	3	3	NUM
ajst-23566	67	28	,	,	PUNCT
ajst-23566	67	29	4	4	NUM
ajst-23566	67	30	]	]	PUNCT
ajst-23566	67	31	.	.	PUNCT
ajst-23566	68	1	(	(	PUNCT
ajst-23566	68	2	3	3	X
ajst-23566	68	3	)	)	PUNCT
ajst-23566	68	4	breeding	breeding	NOUN
ajst-23566	68	5	and	and	CCONJ
ajst-23566	68	6	fermentation	fermentation	NOUN
ajst-23566	68	7	process	process	NOUN
ajst-23566	68	8	innovations	innovation	NOUN
ajst-23566	68	9	:	:	PUNCT
ajst-23566	68	10	professor	professor	NOUN
ajst-23566	68	11	jin	jin	NOUN
ajst-23566	68	12	explored	explore	VERB
ajst-23566	68	13	not	not	PART
ajst-23566	68	14	only	only	ADV
ajst-23566	68	15	the	the	DET
ajst-23566	68	16	breeding	breeding	NOUN
ajst-23566	68	17	of	of	ADP
ajst-23566	68	18	peomycinproducing	peomycinproduce	VERB
ajst-23566	68	19	bacteria	bacteria	NOUN
ajst-23566	68	20	but	but	CCONJ
ajst-23566	68	21	also	also	ADV
ajst-23566	68	22	the	the	DET
ajst-23566	68	23	optimization	optimization	NOUN
ajst-23566	68	24	of	of	ADP
ajst-23566	68	25	fermentation	fermentation	NOUN
ajst-23566	68	26	processes	process	NOUN
ajst-23566	68	27	,	,	PUNCT
ajst-23566	68	28	which	which	PRON
ajst-23566	68	29	are	be	AUX
ajst-23566	68	30	crucial	crucial	ADJ
ajst-23566	68	31	for	for	ADP
ajst-23566	68	32	maximizing	maximize	VERB
ajst-23566	68	33	production	production	NOUN
ajst-23566	68	34	yields	yield	NOUN
ajst-23566	68	35	.	.	PUNCT
ajst-23566	69	1	this	this	DET
ajst-23566	69	2	research	research	NOUN
ajst-23566	69	3	contributes	contribute	VERB
ajst-23566	69	4	significantly	significantly	ADV
ajst-23566	69	5	to	to	ADP
ajst-23566	69	6	understanding	understand	VERB
ajst-23566	69	7	the	the	DET
ajst-23566	69	8	interplay	interplay	NOUN
ajst-23566	69	9	between	between	ADP
ajst-23566	69	10	microbial	microbial	ADJ
ajst-23566	69	11	genetics	genetic	NOUN
ajst-23566	69	12	and	and	CCONJ
ajst-23566	69	13	process	process	NOUN
ajst-23566	69	14	engineering	engineer	VERB
ajst-23566	69	15	[	[	X
ajst-23566	69	16	5	5	NUM
ajst-23566	69	17	]	]	PUNCT
ajst-23566	69	18	.	.	PUNCT
ajst-23566	70	1	(	(	PUNCT
ajst-23566	70	2	4	4	X
ajst-23566	70	3	)	)	PUNCT
ajst-23566	70	4	exploring	explore	VERB
ajst-23566	70	5	alternative	alternative	ADJ
ajst-23566	70	6	antibiotics	antibiotic	NOUN
ajst-23566	70	7	:	:	PUNCT
ajst-23566	70	8	professor	professor	NOUN
ajst-23566	70	9	enderlin	enderlin	NOUN
ajst-23566	70	10	and	and	CCONJ
ajst-23566	70	11	professor	professor	NOUN
ajst-23566	70	12	zhou	zhou	PROPN
ajst-23566	70	13	both	both	PRON
ajst-23566	70	14	contributed	contribute	VERB
ajst-23566	70	15	to	to	ADP
ajst-23566	70	16	the	the	DET
ajst-23566	70	17	broader	broad	ADJ
ajst-23566	70	18	field	field	NOUN
ajst-23566	70	19	of	of	ADP
ajst-23566	70	20	antibiotic	antibiotic	ADJ
ajst-23566	70	21	research	research	NOUN
ajst-23566	70	22	,	,	PUNCT
ajst-23566	70	23	with	with	ADP
ajst-23566	70	24	professor	professor	NOUN
ajst-23566	70	25	enderlin	enderlin	PROPN
ajst-23566	70	26	reviewing	review	VERB
ajst-23566	70	27	alternative	alternative	ADJ
ajst-23566	70	28	agents	agent	NOUN
ajst-23566	70	29	for	for	ADP
ajst-23566	70	30	tularemia	tularemia	NOUN
ajst-23566	70	31	treatment	treatment	NOUN
ajst-23566	70	32	and	and	CCONJ
ajst-23566	70	33	professor	professor	NOUN
ajst-23566	70	34	zhou	zhou	PROPN
ajst-23566	70	35	developing	develop	VERB
ajst-23566	70	36	detection	detection	NOUN
ajst-23566	70	37	methods	method	NOUN
ajst-23566	70	38	for	for	ADP
ajst-23566	70	39	streptomycin	streptomycin	PROPN
ajst-23566	70	40	in	in	ADP
ajst-23566	70	41	honey	honey	PROPN
ajst-23566	70	42	.	.	PUNCT
ajst-23566	71	1	these	these	DET
ajst-23566	71	2	studies	study	NOUN
ajst-23566	71	3	parallel	parallel	VERB
ajst-23566	71	4	the	the	DET
ajst-23566	71	5	requirements	requirement	NOUN
ajst-23566	71	6	for	for	ADP
ajst-23566	71	7	safe	safe	ADJ
ajst-23566	71	8	and	and	CCONJ
ajst-23566	71	9	effective	effective	ADJ
ajst-23566	71	10	production	production	NOUN
ajst-23566	71	11	of	of	ADP
ajst-23566	71	12	avilamycin	avilamycin	NOUN
ajst-23566	71	13	,	,	PUNCT
ajst-23566	71	14	stressing	stress	VERB
ajst-23566	71	15	the	the	DET
ajst-23566	71	16	importance	importance	NOUN
ajst-23566	71	17	of	of	ADP
ajst-23566	71	18	precise	precise	ADJ
ajst-23566	71	19	analytical	analytical	ADJ
ajst-23566	71	20	techniques	technique	NOUN
ajst-23566	71	21	[	[	X
ajst-23566	71	22	6	6	NUM
ajst-23566	71	23	,	,	PUNCT
ajst-23566	71	24	7	7	NUM
ajst-23566	71	25	]	]	PUNCT
ajst-23566	71	26	.	.	PUNCT
ajst-23566	72	1	(	(	PUNCT
ajst-23566	72	2	5	5	X
ajst-23566	72	3	)	)	PUNCT
ajst-23566	72	4	advanced	advanced	ADJ
ajst-23566	72	5	mutagenesis	mutagenesis	NOUN
ajst-23566	72	6	techniques	technique	NOUN
ajst-23566	72	7	:	:	PUNCT
ajst-23566	72	8	the	the	DET
ajst-23566	72	9	studies	study	NOUN
ajst-23566	72	10	by	by	ADP
ajst-23566	72	11	professor	professor	PROPN
ajst-23566	72	12	zhang	zhang	PROPN
ajst-23566	72	13	and	and	CCONJ
ajst-23566	72	14	professor	professor	PROPN
ajst-23566	72	15	yuan	yuan	PROPN
ajst-23566	72	16	on	on	ADP
ajst-23566	72	17	artp	artp	ADJ
ajst-23566	72	18	mutagenesis	mutagenesis	NOUN
ajst-23566	72	19	underscore	underscore	VERB
ajst-23566	72	20	the	the	DET
ajst-23566	72	21	evolution	evolution	NOUN
ajst-23566	72	22	of	of	ADP
ajst-23566	72	23	genetic	genetic	ADJ
ajst-23566	72	24	modification	modification	NOUN
ajst-23566	72	25	techniques	technique	NOUN
ajst-23566	72	26	.	.	PUNCT
ajst-23566	73	1	their	their	PRON
ajst-23566	73	2	work	work	NOUN
ajst-23566	73	3	illustrates	illustrate	VERB
ajst-23566	73	4	how	how	SCONJ
ajst-23566	73	5	modern	modern	ADJ
ajst-23566	73	6	mutagenesis	mutagenesis	NOUN
ajst-23566	73	7	can	can	AUX
ajst-23566	73	8	enhance	enhance	VERB
ajst-23566	73	9	genetic	genetic	ADJ
ajst-23566	73	10	diversity	diversity	NOUN
ajst-23566	73	11	and	and	CCONJ
ajst-23566	73	12	stability	stability	NOUN
ajst-23566	73	13	,	,	PUNCT
ajst-23566	73	14	critical	critical	ADJ
ajst-23566	73	15	factors	factor	NOUN
ajst-23566	73	16	in	in	ADP
ajst-23566	73	17	developing	develop	VERB
ajst-23566	73	18	robust	robust	ADJ
ajst-23566	73	19	avilamycin	avilamycin	NOUN
ajst-23566	73	20	-	-	PUNCT
ajst-23566	73	21	producing	produce	VERB
ajst-23566	73	22	strains	strain	NOUN
ajst-23566	73	23	[	[	X
ajst-23566	73	24	8	8	NUM
ajst-23566	73	25	,	,	PUNCT
ajst-23566	73	26	9	9	NUM
ajst-23566	73	27	]	]	PUNCT
ajst-23566	73	28	.	.	PUNCT
ajst-23566	74	1	(	(	PUNCT
ajst-23566	74	2	6	6	NUM
ajst-23566	74	3	)	)	PUNCT
ajst-23566	74	4	metabolic	metabolic	NOUN
ajst-23566	74	5	engineering	engineering	NOUN
ajst-23566	74	6	for	for	ADP
ajst-23566	74	7	enhanced	enhanced	ADJ
ajst-23566	74	8	production	production	NOUN
ajst-23566	74	9	:	:	PUNCT
ajst-23566	74	10	the	the	DET
ajst-23566	74	11	pivotal	pivotal	ADJ
ajst-23566	74	12	study	study	NOUN
ajst-23566	74	13	by	by	ADP
ajst-23566	74	14	professor	professor	NOUN
ajst-23566	74	15	butler	butler	NOUN
ajst-23566	74	16	on	on	ADP
ajst-23566	74	17	the	the	DET
ajst-23566	74	18	manipulation	manipulation	NOUN
ajst-23566	74	19	of	of	ADP
ajst-23566	74	20	104	104	NUM
ajst-23566	74	21	primary	primary	ADJ
ajst-23566	74	22	carbon	carbon	NOUN
ajst-23566	74	23	metabolism	metabolism	NOUN
ajst-23566	74	24	in	in	ADP
ajst-23566	74	25	streptomyces	streptomyce	NOUN
ajst-23566	74	26	lividans	lividan	NOUN
ajst-23566	74	27	exemplifies	exemplify	VERB
ajst-23566	74	28	the	the	DET
ajst-23566	74	29	practical	practical	ADJ
ajst-23566	74	30	applications	application	NOUN
ajst-23566	74	31	of	of	ADP
ajst-23566	74	32	metabolic	metabolic	NOUN
ajst-23566	74	33	engineering	engineering	NOUN
ajst-23566	74	34	.	.	PUNCT
ajst-23566	75	1	by	by	ADP
ajst-23566	75	2	adjusting	adjust	VERB
ajst-23566	75	3	key	key	ADJ
ajst-23566	75	4	metabolic	metabolic	NOUN
ajst-23566	75	5	pathways	pathway	NOUN
ajst-23566	75	6	,	,	PUNCT
ajst-23566	75	7	he	he	PRON
ajst-23566	75	8	successfully	successfully	ADV
ajst-23566	75	9	increased	increase	VERB
ajst-23566	75	10	the	the	DET
ajst-23566	75	11	production	production	NOUN
ajst-23566	75	12	yields	yield	NOUN
ajst-23566	75	13	of	of	ADP
ajst-23566	75	14	antibiotics	antibiotic	NOUN
ajst-23566	75	15	,	,	PUNCT
ajst-23566	75	16	providing	provide	VERB
ajst-23566	75	17	a	a	DET
ajst-23566	75	18	valuable	valuable	ADJ
ajst-23566	75	19	model	model	NOUN
ajst-23566	75	20	for	for	ADP
ajst-23566	75	21	similar	similar	ADJ
ajst-23566	75	22	enhancements	enhancement	NOUN
ajst-23566	75	23	in	in	ADP
ajst-23566	75	24	avilamycin	avilamycin	NOUN
ajst-23566	75	25	production	production	NOUN
ajst-23566	75	26	[	[	X
ajst-23566	75	27	10	10	NUM
ajst-23566	75	28	]	]	PUNCT
ajst-23566	75	29	.	.	PUNCT
ajst-23566	76	1	(	(	PUNCT
ajst-23566	76	2	7	7	X
ajst-23566	76	3	)	)	PUNCT
ajst-23566	76	4	metabolic	metabolic	NOUN
ajst-23566	76	5	engineering	engineering	NOUN
ajst-23566	76	6	for	for	ADP
ajst-23566	76	7	enhanced	enhanced	ADJ
ajst-23566	76	8	production	production	NOUN
ajst-23566	76	9	:	:	PUNCT
ajst-23566	76	10	butler	butler	PROPN
ajst-23566	76	11	et	et	PROPN
ajst-23566	76	12	al	al	PROPN
ajst-23566	76	13	.	.	PROPN
ajst-23566	76	14	conducted	conduct	VERB
ajst-23566	76	15	a	a	DET
ajst-23566	76	16	detailed	detailed	ADJ
ajst-23566	76	17	study	study	NOUN
ajst-23566	76	18	on	on	ADP
ajst-23566	76	19	the	the	DET
ajst-23566	76	20	engineering	engineering	NOUN
ajst-23566	76	21	of	of	ADP
ajst-23566	76	22	primary	primary	ADJ
ajst-23566	76	23	carbon	carbon	NOUN
ajst-23566	76	24	metabolism	metabolism	NOUN
ajst-23566	76	25	in	in	ADP
ajst-23566	76	26	streptomyces	streptomyce	NOUN
ajst-23566	76	27	lividans	lividan	NOUN
ajst-23566	76	28	,	,	PUNCT
ajst-23566	76	29	aiming	aim	VERB
ajst-23566	76	30	to	to	PART
ajst-23566	76	31	increase	increase	VERB
ajst-23566	76	32	the	the	DET
ajst-23566	76	33	production	production	NOUN
ajst-23566	76	34	of	of	ADP
ajst-23566	76	35	antibiotics	antibiotic	NOUN
ajst-23566	76	36	.	.	PUNCT
ajst-23566	77	1	by	by	ADP
ajst-23566	77	2	genetically	genetically	ADV
ajst-23566	77	3	altering	alter	VERB
ajst-23566	77	4	key	key	ADJ
ajst-23566	77	5	enzymes	enzyme	NOUN
ajst-23566	77	6	involved	involve	VERB
ajst-23566	77	7	in	in	ADP
ajst-23566	77	8	central	central	ADJ
ajst-23566	77	9	metabolic	metabolic	NOUN
ajst-23566	77	10	pathways	pathway	NOUN
ajst-23566	77	11	,	,	PUNCT
ajst-23566	77	12	they	they	PRON
ajst-23566	77	13	successfully	successfully	ADV
ajst-23566	77	14	redirected	redirect	VERB
ajst-23566	77	15	precursor	precursor	NOUN
ajst-23566	77	16	metabolites	metabolite	NOUN
ajst-23566	77	17	to	to	PART
ajst-23566	77	18	enhance	enhance	VERB
ajst-23566	77	19	antibiotic	antibiotic	ADJ
ajst-23566	77	20	synthesis	synthesis	NOUN
ajst-23566	77	21	.	.	PUNCT
ajst-23566	78	1	this	this	DET
ajst-23566	78	2	research	research	NOUN
ajst-23566	78	3	demonstrates	demonstrate	VERB
ajst-23566	78	4	how	how	SCONJ
ajst-23566	78	5	targeted	target	VERB
ajst-23566	78	6	metabolic	metabolic	NOUN
ajst-23566	78	7	engineering	engineering	NOUN
ajst-23566	78	8	can	can	AUX
ajst-23566	78	9	significantly	significantly	ADV
ajst-23566	78	10	improve	improve	VERB
ajst-23566	78	11	the	the	DET
ajst-23566	78	12	yield	yield	NOUN
ajst-23566	78	13	and	and	CCONJ
ajst-23566	78	14	efficiency	efficiency	NOUN
ajst-23566	78	15	of	of	ADP
ajst-23566	78	16	antibiotic	antibiotic	ADJ
ajst-23566	78	17	production	production	NOUN
ajst-23566	78	18	,	,	PUNCT
ajst-23566	78	19	offering	offer	VERB
ajst-23566	78	20	insights	insight	NOUN
ajst-23566	78	21	into	into	ADP
ajst-23566	78	22	the	the	DET
ajst-23566	78	23	potential	potential	NOUN
ajst-23566	78	24	for	for	ADP
ajst-23566	78	25	future	future	ADJ
ajst-23566	78	26	biotechnological	biotechnological	ADJ
ajst-23566	78	27	applications	application	NOUN
ajst-23566	78	28	in	in	ADP
ajst-23566	78	29	microbial	microbial	ADJ
ajst-23566	78	30	fermentation	fermentation	NOUN
ajst-23566	78	31	processes	process	NOUN
ajst-23566	78	32	[	[	X
ajst-23566	78	33	11	11	NUM
ajst-23566	78	34	]	]	PUNCT
ajst-23566	78	35	.	.	PUNCT
ajst-23566	79	1	these	these	DET
ajst-23566	79	2	case	case	NOUN
ajst-23566	79	3	studies	study	NOUN
ajst-23566	79	4	not	not	PART
ajst-23566	79	5	only	only	ADV
ajst-23566	79	6	reveal	reveal	VERB
ajst-23566	79	7	the	the	DET
ajst-23566	79	8	diversity	diversity	NOUN
ajst-23566	79	9	of	of	ADP
ajst-23566	79	10	applied	apply	VERB
ajst-23566	79	11	approaches	approach	NOUN
ajst-23566	79	12	in	in	ADP
ajst-23566	79	13	increasing	increase	VERB
ajst-23566	79	14	avilamycin	avilamycin	NOUN
ajst-23566	79	15	production	production	NOUN
ajst-23566	79	16	but	but	CCONJ
ajst-23566	79	17	also	also	ADV
ajst-23566	79	18	emphasize	emphasize	VERB
ajst-23566	79	19	the	the	DET
ajst-23566	79	20	critical	critical	ADJ
ajst-23566	79	21	need	need	NOUN
ajst-23566	79	22	for	for	ADP
ajst-23566	79	23	combining	combine	VERB
ajst-23566	79	24	traditional	traditional	ADJ
ajst-23566	79	25	practices	practice	NOUN
ajst-23566	79	26	with	with	ADP
ajst-23566	79	27	innovative	innovative	ADJ
ajst-23566	79	28	genetic	genetic	ADJ
ajst-23566	79	29	technologies	technology	NOUN
ajst-23566	79	30	.	.	PUNCT
ajst-23566	80	1	each	each	DET
ajst-23566	80	2	study	study	NOUN
ajst-23566	80	3	contributes	contribute	VERB
ajst-23566	80	4	to	to	ADP
ajst-23566	80	5	the	the	DET
ajst-23566	80	6	overarching	overarching	ADJ
ajst-23566	80	7	goal	goal	NOUN
ajst-23566	80	8	of	of	ADP
ajst-23566	80	9	enhancing	enhance	VERB
ajst-23566	80	10	both	both	CCONJ
ajst-23566	80	11	the	the	DET
ajst-23566	80	12	yield	yield	NOUN
ajst-23566	80	13	and	and	CCONJ
ajst-23566	80	14	quality	quality	NOUN
ajst-23566	80	15	of	of	ADP
ajst-23566	80	16	avilamycin	avilamycin	NOUN
ajst-23566	80	17	,	,	PUNCT
ajst-23566	80	18	indicating	indicate	VERB
ajst-23566	80	19	effective	effective	ADJ
ajst-23566	80	20	strategies	strategy	NOUN
ajst-23566	80	21	for	for	ADP
ajst-23566	80	22	achieving	achieve	VERB
ajst-23566	80	23	the	the	DET
ajst-23566	80	24	set	set	ADJ
ajst-23566	80	25	objectives	objective	NOUN
ajst-23566	80	26	.	.	PUNCT
ajst-23566	81	1	7	7	X
ajst-23566	81	2	.	.	X
ajst-23566	81	3	integration	integration	NOUN
ajst-23566	81	4	of	of	ADP
ajst-23566	81	5	computational	computational	ADJ
ajst-23566	81	6	tools	tool	NOUN
ajst-23566	81	7	in	in	ADP
ajst-23566	81	8	avilamycin	avilamycin	NOUN
ajst-23566	81	9	breeding	breed	VERB
ajst-23566	81	10	in	in	ADP
ajst-23566	81	11	turn	turn	NOUN
ajst-23566	81	12	,	,	PUNCT
ajst-23566	81	13	this	this	DET
ajst-23566	81	14	integration	integration	NOUN
ajst-23566	81	15	of	of	ADP
ajst-23566	81	16	data	datum	NOUN
ajst-23566	81	17	analytics	analytic	NOUN
ajst-23566	81	18	and	and	CCONJ
ajst-23566	81	19	machine	machine	NOUN
ajst-23566	81	20	learning	learn	VERB
ajst-23566	81	21	with	with	ADP
ajst-23566	81	22	the	the	DET
ajst-23566	81	23	breeding	breeding	NOUN
ajst-23566	81	24	of	of	ADP
ajst-23566	81	25	avilamycin	avilamycin	NOUN
ajst-23566	81	26	-	-	PUNCT
ajst-23566	81	27	producing	produce	VERB
ajst-23566	81	28	bacteria	bacteria	NOUN
ajst-23566	81	29	may	may	AUX
ajst-23566	81	30	have	have	AUX
ajst-23566	81	31	transformative	transformative	VERB
ajst-23566	81	32	potential	potential	NOUN
ajst-23566	81	33	with	with	ADP
ajst-23566	81	34	increased	increase	VERB
ajst-23566	81	35	computational	computational	ADJ
ajst-23566	81	36	biology	biology	NOUN
ajst-23566	81	37	.	.	PUNCT
ajst-23566	82	1	these	these	PRON
ajst-23566	82	2	are	be	AUX
ajst-23566	82	3	technologies	technology	NOUN
ajst-23566	82	4	which	which	PRON
ajst-23566	82	5	offer	offer	VERB
ajst-23566	82	6	a	a	DET
ajst-23566	82	7	way	way	NOUN
ajst-23566	82	8	of	of	ADP
ajst-23566	82	9	very	very	ADV
ajst-23566	82	10	fast	fast	ADJ
ajst-23566	82	11	genotype	genotype	NOUN
ajst-23566	82	12	-	-	PUNCT
ajst-23566	82	13	phenotype	phenotype	NOUN
ajst-23566	82	14	relations	relation	NOUN
ajst-23566	82	15	and	and	CCONJ
ajst-23566	82	16	predictiveness	predictiveness	NOUN
ajst-23566	82	17	that	that	PRON
ajst-23566	82	18	may	may	AUX
ajst-23566	82	19	accelerate	accelerate	VERB
ajst-23566	82	20	strain	strain	NOUN
ajst-23566	82	21	-	-	PUNCT
ajst-23566	82	22	improvement	improvement	NOUN
ajst-23566	82	23	programs	program	NOUN
ajst-23566	82	24	.	.	PUNCT
ajst-23566	83	1	the	the	DET
ajst-23566	83	2	use	use	NOUN
ajst-23566	83	3	of	of	ADP
ajst-23566	83	4	machine	machine	NOUN
ajst-23566	83	5	-	-	PUNCT
ajst-23566	83	6	learning	learn	VERB
ajst-23566	83	7	algorithms	algorithm	NOUN
ajst-23566	83	8	in	in	ADP
ajst-23566	83	9	prediction	prediction	NOUN
ajst-23566	83	10	of	of	ADP
ajst-23566	83	11	the	the	DET
ajst-23566	83	12	best	good	ADJ
ajst-23566	83	13	genetic	genetic	ADJ
ajst-23566	83	14	modifications	modification	NOUN
ajst-23566	83	15	to	to	PART
ajst-23566	83	16	improve	improve	VERB
ajst-23566	83	17	the	the	DET
ajst-23566	83	18	production	production	NOUN
ajst-23566	83	19	of	of	ADP
ajst-23566	83	20	effective	effective	ADJ
ajst-23566	83	21	antibiotics	antibiotic	NOUN
ajst-23566	83	22	is	be	AUX
ajst-23566	83	23	done	do	VERB
ajst-23566	83	24	using	use	VERB
ajst-23566	83	25	enormous	enormous	ADJ
ajst-23566	83	26	genomic	genomic	ADJ
ajst-23566	83	27	sequencing	sequence	VERB
ajst-23566	83	28	data	datum	NOUN
ajst-23566	83	29	.	.	PUNCT
ajst-23566	84	1	computational	computational	ADJ
ajst-23566	84	2	tools	tool	NOUN
ajst-23566	84	3	,	,	PUNCT
ajst-23566	84	4	applied	apply	VERB
ajst-23566	84	5	both	both	PRON
ajst-23566	84	6	during	during	ADP
ajst-23566	84	7	selection	selection	NOUN
ajst-23566	84	8	and	and	CCONJ
ajst-23566	84	9	optimization	optimization	NOUN
ajst-23566	84	10	,	,	PUNCT
ajst-23566	84	11	render	render	VERB
ajst-23566	84	12	the	the	DET
ajst-23566	84	13	cycles	cycle	NOUN
ajst-23566	84	14	of	of	ADP
ajst-23566	84	15	development	development	NOUN
ajst-23566	84	16	more	more	ADV
ajst-23566	84	17	effective	effective	ADJ
ajst-23566	84	18	,	,	PUNCT
ajst-23566	84	19	with	with	ADP
ajst-23566	84	20	consequent	consequent	ADJ
ajst-23566	84	21	higher	high	ADJ
ajst-23566	84	22	yield	yield	NOUN
ajst-23566	84	23	and	and	CCONJ
ajst-23566	84	24	quality	quality	NOUN
ajst-23566	84	25	of	of	ADP
ajst-23566	84	26	avilamycin	avilamycin	NOUN
ajst-23566	84	27	.	.	PUNCT
ajst-23566	85	1	this	this	DET
ajst-23566	85	2	step	step	NOUN
ajst-23566	85	3	is	be	AUX
ajst-23566	85	4	of	of	ADP
ajst-23566	85	5	paramount	paramount	ADJ
ajst-23566	85	6	importance	importance	NOUN
ajst-23566	85	7	in	in	ADP
ajst-23566	85	8	providing	provide	VERB
ajst-23566	85	9	a	a	DET
ajst-23566	85	10	way	way	NOUN
ajst-23566	85	11	forward	forward	ADV
ajst-23566	85	12	toward	toward	ADP
ajst-23566	85	13	advanced	advanced	ADJ
ajst-23566	85	14	,	,	PUNCT
ajst-23566	85	15	data	datum	NOUN
ajst-23566	85	16	-	-	PUNCT
ajst-23566	85	17	driven	drive	VERB
ajst-23566	85	18	breeding	breeding	NOUN
ajst-23566	85	19	strategies	strategy	NOUN
ajst-23566	85	20	in	in	ADP
ajst-23566	85	21	microbial	microbial	ADJ
ajst-23566	85	22	biotechnology	biotechnology	NOUN
ajst-23566	85	23	.	.	PUNCT
ajst-23566	86	1	8	8	X
ajst-23566	86	2	.	.	PUNCT
ajst-23566	87	1	future	future	ADJ
ajst-23566	87	2	directions	direction	NOUN
ajst-23566	87	3	in	in	ADP
ajst-23566	87	4	avilamycin	avilamycin	PROPN
ajst-23566	87	5	research	research	NOUN
ajst-23566	87	6	based	base	VERB
ajst-23566	87	7	on	on	ADP
ajst-23566	87	8	this	this	DET
ajst-23566	87	9	background	background	NOUN
ajst-23566	87	10	,	,	PUNCT
ajst-23566	87	11	further	further	ADJ
ajst-23566	87	12	research	research	NOUN
ajst-23566	87	13	on	on	ADP
ajst-23566	87	14	the	the	DET
ajst-23566	87	15	avilamycin	avilamycin	NOUN
ajst-23566	87	16	breeding	breeding	NOUN
ajst-23566	87	17	area	area	NOUN
ajst-23566	87	18	is	be	AUX
ajst-23566	87	19	expected	expect	VERB
ajst-23566	87	20	to	to	PART
ajst-23566	87	21	go	go	VERB
ajst-23566	87	22	in	in	ADP
ajst-23566	87	23	the	the	DET
ajst-23566	87	24	direction	direction	NOUN
ajst-23566	87	25	of	of	ADP
ajst-23566	87	26	deeper	deep	ADJ
ajst-23566	87	27	genetic	genetic	ADJ
ajst-23566	87	28	knowledge	knowledge	NOUN
ajst-23566	87	29	and	and	CCONJ
ajst-23566	87	30	the	the	DET
ajst-23566	87	31	implementation	implementation	NOUN
ajst-23566	87	32	of	of	ADP
ajst-23566	87	33	new	new	ADJ
ajst-23566	87	34	biotechnological	biotechnological	ADJ
ajst-23566	87	35	tools	tool	NOUN
ajst-23566	87	36	for	for	ADP
ajst-23566	87	37	further	further	ADJ
ajst-23566	87	38	improvements	improvement	NOUN
ajst-23566	87	39	in	in	ADP
ajst-23566	87	40	the	the	DET
ajst-23566	87	41	potential	potential	NOUN
ajst-23566	87	42	of	of	ADP
ajst-23566	87	43	avilamycin	avilamycin	NOUN
ajst-23566	87	44	-	-	PUNCT
ajst-23566	87	45	producing	produce	VERB
ajst-23566	87	46	bacteria	bacteria	NOUN
ajst-23566	87	47	.	.	PUNCT
ajst-23566	88	1	among	among	ADP
ajst-23566	88	2	such	such	ADJ
ajst-23566	88	3	leading	lead	VERB
ajst-23566	88	4	points	point	NOUN
ajst-23566	88	5	are	be	AUX
ajst-23566	88	6	novel	novel	ADJ
ajst-23566	88	7	targets	target	NOUN
ajst-23566	88	8	in	in	ADP
ajst-23566	88	9	genomics	genomic	NOUN
ajst-23566	88	10	and	and	CCONJ
ajst-23566	88	11	synthetic	synthetic	ADJ
ajst-23566	88	12	biology	biology	NOUN
ajst-23566	88	13	.	.	PUNCT
ajst-23566	89	1	these	these	DET
ajst-23566	89	2	strategies	strategy	NOUN
ajst-23566	89	3	aim	aim	VERB
ajst-23566	89	4	to	to	PART
ajst-23566	89	5	make	make	VERB
ajst-23566	89	6	those	those	DET
ajst-23566	89	7	bacteria	bacteria	NOUN
ajst-23566	89	8	produce	produce	VERB
ajst-23566	89	9	more	more	ADJ
ajst-23566	89	10	avilamycin	avilamycin	ADV
ajst-23566	89	11	and	and	CCONJ
ajst-23566	89	12	be	be	AUX
ajst-23566	89	13	resistant	resistant	ADJ
ajst-23566	89	14	to	to	ADP
ajst-23566	89	15	environmental	environmental	ADJ
ajst-23566	89	16	stress	stress	NOUN
ajst-23566	89	17	,	,	PUNCT
ajst-23566	89	18	improving	improve	VERB
ajst-23566	89	19	sustainability	sustainability	NOUN
ajst-23566	89	20	at	at	ADP
ajst-23566	89	21	the	the	DET
ajst-23566	89	22	same	same	ADJ
ajst-23566	89	23	time	time	NOUN
ajst-23566	89	24	by	by	ADP
ajst-23566	89	25	eliminating	eliminate	VERB
ajst-23566	89	26	waste	waste	NOUN
ajst-23566	89	27	.	.	PUNCT
ajst-23566	90	1	discovery	discovery	NOUN
ajst-23566	90	2	and	and	CCONJ
ajst-23566	90	3	characterization	characterization	NOUN
ajst-23566	90	4	of	of	ADP
ajst-23566	90	5	novel	novel	ADJ
ajst-23566	90	6	microbial	microbial	ADJ
ajst-23566	90	7	strains	strain	NOUN
ajst-23566	90	8	from	from	ADP
ajst-23566	90	9	the	the	DET
ajst-23566	90	10	diversity	diversity	NOUN
ajst-23566	90	11	of	of	ADP
ajst-23566	90	12	ecological	ecological	ADJ
ajst-23566	90	13	niches	niche	NOUN
ajst-23566	90	14	go	go	VERB
ajst-23566	90	15	on	on	ADP
ajst-23566	90	16	to	to	PART
ajst-23566	90	17	make	make	VERB
ajst-23566	90	18	the	the	DET
ajst-23566	90	19	gene	gene	NOUN
ajst-23566	90	20	pool	pool	NOUN
ajst-23566	90	21	widely	widely	ADV
ajst-23566	90	22	available	available	ADJ
ajst-23566	90	23	and	and	CCONJ
ajst-23566	90	24	possibly	possibly	ADV
ajst-23566	90	25	introduce	introduce	VERB
ajst-23566	90	26	scope	scope	NOUN
ajst-23566	90	27	for	for	ADP
ajst-23566	90	28	improvements	improvement	NOUN
ajst-23566	90	29	in	in	ADP
ajst-23566	90	30	disease	disease	NOUN
ajst-23566	90	31	resistance	resistance	NOUN
ajst-23566	90	32	and	and	CCONJ
ajst-23566	90	33	adaptability	adaptability	NOUN
ajst-23566	90	34	to	to	ADP
ajst-23566	90	35	different	different	ADJ
ajst-23566	90	36	fermentation	fermentation	NOUN
ajst-23566	90	37	conditions	condition	NOUN
ajst-23566	90	38	.	.	PUNCT
ajst-23566	91	1	further	further	ADJ
ajst-23566	91	2	inclusion	inclusion	NOUN
ajst-23566	91	3	of	of	ADP
ajst-23566	91	4	data	datum	NOUN
ajst-23566	91	5	analytics	analytic	NOUN
ajst-23566	91	6	and	and	CCONJ
ajst-23566	91	7	machine	machine	NOUN
ajst-23566	91	8	learning	learning	NOUN
ajst-23566	91	9	in	in	ADP
ajst-23566	91	10	the	the	DET
ajst-23566	91	11	process	process	NOUN
ajst-23566	91	12	of	of	ADP
ajst-23566	91	13	breeding	breeding	NOUN
ajst-23566	91	14	will	will	AUX
ajst-23566	91	15	help	help	VERB
ajst-23566	91	16	in	in	ADP
ajst-23566	91	17	the	the	DET
ajst-23566	91	18	identification	identification	NOUN
ajst-23566	91	19	of	of	ADP
ajst-23566	91	20	better	well	ADJ
ajst-23566	91	21	breeding	breeding	NOUN
ajst-23566	91	22	strategies	strategy	NOUN
ajst-23566	91	23	and	and	CCONJ
ajst-23566	91	24	conditions	condition	NOUN
ajst-23566	91	25	more	more	ADV
ajst-23566	91	26	quickly	quickly	ADV
ajst-23566	91	27	,	,	PUNCT
ajst-23566	91	28	leading	lead	VERB
ajst-23566	91	29	to	to	ADP
ajst-23566	91	30	a	a	DET
ajst-23566	91	31	reduction	reduction	NOUN
ajst-23566	91	32	in	in	ADP
ajst-23566	91	33	time	time	NOUN
ajst-23566	91	34	and	and	CCONJ
ajst-23566	91	35	cost	cost	NOUN
ajst-23566	91	36	of	of	ADP
ajst-23566	91	37	development	development	NOUN
ajst-23566	91	38	cycles	cycle	NOUN
ajst-23566	91	39	.	.	PUNCT
ajst-23566	92	1	these	these	DET
ajst-23566	92	2	forward	forward	ADV
ajst-23566	92	3	-	-	PUNCT
ajst-23566	92	4	looking	look	VERB
ajst-23566	92	5	approaches	approach	NOUN
ajst-23566	92	6	are	be	AUX
ajst-23566	92	7	indicative	indicative	ADJ
ajst-23566	92	8	of	of	ADP
ajst-23566	92	9	a	a	DET
ajst-23566	92	10	commitment	commitment	NOUN
ajst-23566	92	11	to	to	ADP
ajst-23566	92	12	addressing	address	VERB
ajst-23566	92	13	both	both	CCONJ
ajst-23566	92	14	the	the	DET
ajst-23566	92	15	dual	dual	ADJ
ajst-23566	92	16	challenges	challenge	NOUN
ajst-23566	92	17	of	of	ADP
ajst-23566	92	18	meeting	meet	VERB
ajst-23566	92	19	global	global	ADJ
ajst-23566	92	20	antibiotic	antibiotic	ADJ
ajst-23566	92	21	demand	demand	NOUN
ajst-23566	92	22	as	as	ADV
ajst-23566	92	23	well	well	ADV
ajst-23566	92	24	as	as	ADP
ajst-23566	92	25	environment	environment	NOUN
ajst-23566	92	26	and	and	CCONJ
ajst-23566	92	27	safety	safety	NOUN
ajst-23566	92	28	standards	standard	NOUN
ajst-23566	92	29	.	.	PUNCT
ajst-23566	93	1	9	9	X
ajst-23566	93	2	.	.	X
ajst-23566	93	3	conclusion	conclusion	NOUN
ajst-23566	93	4	in	in	ADP
ajst-23566	93	5	conclusion	conclusion	NOUN
ajst-23566	93	6	,	,	PUNCT
ajst-23566	93	7	this	this	PRON
ajst-23566	93	8	is	be	AUX
ajst-23566	93	9	the	the	DET
ajst-23566	93	10	critical	critical	ADJ
ajst-23566	93	11	point	point	NOUN
ajst-23566	93	12	where	where	SCONJ
ajst-23566	93	13	the	the	DET
ajst-23566	93	14	breeding	breeding	NOUN
ajst-23566	93	15	of	of	ADP
ajst-23566	93	16	avilamycin	avilamycin	NOUN
ajst-23566	93	17	-	-	PUNCT
ajst-23566	93	18	producing	produce	VERB
ajst-23566	93	19	bacteria	bacteria	NOUN
ajst-23566	93	20	finally	finally	ADV
ajst-23566	93	21	integrates	integrate	VERB
ajst-23566	93	22	between	between	ADP
ajst-23566	93	23	its	its	PRON
ajst-23566	93	24	traditional	traditional	ADJ
ajst-23566	93	25	and	and	CCONJ
ajst-23566	93	26	modern	modern	ADJ
ajst-23566	93	27	biotechnological	biotechnological	ADJ
ajst-23566	93	28	advances	advance	NOUN
ajst-23566	93	29	,	,	PUNCT
ajst-23566	93	30	therefore	therefore	ADV
ajst-23566	93	31	making	make	VERB
ajst-23566	93	32	the	the	DET
ajst-23566	93	33	improvement	improvement	NOUN
ajst-23566	93	34	of	of	ADP
ajst-23566	93	35	avilamycin	avilamycin	NOUN
ajst-23566	93	36	yield	yield	NOUN
ajst-23566	93	37	and	and	CCONJ
ajst-23566	93	38	quality	quality	NOUN
ajst-23566	93	39	a	a	DET
ajst-23566	93	40	breeze	breeze	NOUN
ajst-23566	93	41	yet	yet	ADV
ajst-23566	93	42	squarely	squarely	ADV
ajst-23566	93	43	facing	face	VERB
ajst-23566	93	44	the	the	DET
ajst-23566	93	45	increased	increase	VERB
ajst-23566	93	46	global	global	ADJ
ajst-23566	93	47	demand	demand	NOUN
ajst-23566	93	48	on	on	ADP
ajst-23566	93	49	the	the	DET
ajst-23566	93	50	one	one	NUM
ajst-23566	93	51	side	side	NOUN
ajst-23566	93	52	and	and	CCONJ
ajst-23566	93	53	sustainability	sustainability	NOUN
ajst-23566	93	54	in	in	ADP
ajst-23566	93	55	antibiotic	antibiotic	ADJ
ajst-23566	93	56	production	production	NOUN
ajst-23566	93	57	on	on	ADP
ajst-23566	93	58	the	the	DET
ajst-23566	93	59	other	other	ADJ
ajst-23566	93	60	.	.	PUNCT
ajst-23566	94	1	therefore	therefore	ADV
ajst-23566	94	2	,	,	PUNCT
ajst-23566	94	3	much	much	ADJ
ajst-23566	94	4	research	research	NOUN
ajst-23566	94	5	and	and	CCONJ
ajst-23566	94	6	development	development	NOUN
ajst-23566	94	7	in	in	ADP
ajst-23566	94	8	this	this	DET
ajst-23566	94	9	area	area	NOUN
ajst-23566	94	10	for	for	ADP
ajst-23566	94	11	the	the	DET
ajst-23566	94	12	future	future	NOUN
ajst-23566	94	13	are	be	AUX
ajst-23566	94	14	needed	need	VERB
ajst-23566	94	15	to	to	PART
ajst-23566	94	16	bring	bring	VERB
ajst-23566	94	17	out	out	ADP
ajst-23566	94	18	further	further	ADJ
ajst-23566	94	19	refinement	refinement	NOUN
ajst-23566	94	20	in	in	ADP
ajst-23566	94	21	these	these	DET
ajst-23566	94	22	techniques	technique	NOUN
ajst-23566	94	23	and	and	CCONJ
ajst-23566	94	24	outshine	outshine	VERB
ajst-23566	94	25	the	the	DET
ajst-23566	94	26	challenges	challenge	NOUN
ajst-23566	94	27	in	in	ADP
ajst-23566	94	28	production	production	NOUN
ajst-23566	94	29	capacity	capacity	NOUN
ajst-23566	94	30	and	and	CCONJ
ajst-23566	94	31	efficiency	efficiency	NOUN
ajst-23566	94	32	that	that	PRON
ajst-23566	94	33	are	be	AUX
ajst-23566	94	34	inherent	inherent	ADJ
ajst-23566	94	35	.	.	PUNCT
ajst-23566	95	1	with	with	ADP
ajst-23566	95	2	further	further	ADJ
ajst-23566	95	3	developments	development	NOUN
ajst-23566	95	4	in	in	ADP
ajst-23566	95	5	the	the	DET
ajst-23566	95	6	microbial	microbial	ADJ
ajst-23566	95	7	genetic	genetic	ADJ
ajst-23566	95	8	toolbox	toolbox	NOUN
ajst-23566	95	9	,	,	PUNCT
ajst-23566	95	10	robustness	robustness	NOUN
ajst-23566	95	11	of	of	ADP
ajst-23566	95	12	the	the	DET
ajst-23566	95	13	strains	strain	NOUN
ajst-23566	95	14	,	,	PUNCT
ajst-23566	95	15	and	and	CCONJ
ajst-23566	95	16	the	the	DET
ajst-23566	95	17	optimization	optimization	NOUN
ajst-23566	95	18	of	of	ADP
ajst-23566	95	19	production	production	NOUN
ajst-23566	95	20	processes	process	NOUN
ajst-23566	95	21	,	,	PUNCT
ajst-23566	95	22	the	the	DET
ajst-23566	95	23	field	field	NOUN
ajst-23566	95	24	can	can	AUX
ajst-23566	95	25	ensure	ensure	VERB
ajst-23566	95	26	its	its	PRON
ajst-23566	95	27	place	place	NOUN
ajst-23566	95	28	in	in	ADP
ajst-23566	95	29	guaranteeing	guarantee	VERB
ajst-23566	95	30	a	a	DET
ajst-23566	95	31	steady	steady	ADJ
ajst-23566	95	32	supply	supply	NOUN
ajst-23566	95	33	of	of	ADP
ajst-23566	95	34	this	this	DET
ajst-23566	95	35	vital	vital	ADJ
ajst-23566	95	36	antibiotic	antibiotic	NOUN
ajst-23566	95	37	—	—	PUNCT
ajst-23566	95	38	a	a	DET
ajst-23566	95	39	factor	factor	NOUN
ajst-23566	95	40	of	of	ADP
ajst-23566	95	41	huge	huge	ADJ
ajst-23566	95	42	effects	effect	NOUN
ajst-23566	95	43	in	in	ADP
ajst-23566	95	44	the	the	DET
ajst-23566	95	45	health	health	NOUN
ajst-23566	95	46	sectors	sector	NOUN
ajst-23566	95	47	and	and	CCONJ
ajst-23566	95	48	global	global	ADJ
ajst-23566	95	49	livestock	livestock	NOUN
ajst-23566	95	50	industries	industry	NOUN
ajst-23566	95	51	.	.	PUNCT
ajst-23566	96	1	references	reference	NOUN
ajst-23566	96	2	[	[	X
ajst-23566	96	3	1	1	NUM
ajst-23566	96	4	]	]	X
ajst-23566	96	5	zhao	zhao	PROPN
ajst-23566	96	6	,	,	PUNCT
ajst-23566	96	7	s.	s.	PROPN
ajst-23566	96	8	,	,	PUNCT
ajst-23566	96	9	zhang	zhang	PROPN
ajst-23566	96	10	,	,	PUNCT
ajst-23566	96	11	y.	y.	PROPN
ajst-23566	96	12	,	,	PUNCT
ajst-23566	96	13	ji	ji	PROPN
ajst-23566	96	14	,	,	PUNCT
ajst-23566	96	15	s.	s.	PROPN
ajst-23566	96	16	,	,	PUNCT
ajst-23566	96	17	et	et	PROPN
ajst-23566	96	18	al	al	PROPN
ajst-23566	96	19	.	.	PUNCT
ajst-23566	96	20	(	(	PUNCT
ajst-23566	96	21	2008	2008	NUM
ajst-23566	96	22	)	)	PUNCT
ajst-23566	96	23	.	.	PUNCT
ajst-23566	97	1	selection	selection	NOUN
ajst-23566	97	2	and	and	CCONJ
ajst-23566	97	3	development	development	NOUN
ajst-23566	97	4	of	of	ADP
ajst-23566	97	5	high	high	ADV
ajst-23566	97	6	-	-	PUNCT
ajst-23566	97	7	yielding	yield	VERB
ajst-23566	97	8	strains	strain	NOUN
ajst-23566	97	9	of	of	ADP
ajst-23566	97	10	avilamycin	avilamycin	NOUN
ajst-23566	97	11	.	.	PUNCT
ajst-23566	98	1	chinese	chinese	ADJ
ajst-23566	98	2	journal	journal	PROPN
ajst-23566	98	3	of	of	ADP
ajst-23566	98	4	biochemical	biochemical	ADJ
ajst-23566	98	5	drugs	drug	NOUN
ajst-23566	98	6	,	,	PUNCT
ajst-23566	98	7	(	(	PUNCT
ajst-23566	98	8	1	1	NUM
ajst-23566	98	9	)	)	PUNCT
ajst-23566	98	10	.	.	PUNCT
ajst-23566	99	1	[	[	X
ajst-23566	99	2	2	2	NUM
ajst-23566	99	3	]	]	X
ajst-23566	99	4	jin	jin	NOUN
ajst-23566	99	5	,	,	PUNCT
ajst-23566	99	6	l.	l.	PROPN
ajst-23566	99	7	(	(	PUNCT
ajst-23566	99	8	2006	2006	NUM
ajst-23566	99	9	)	)	PUNCT
ajst-23566	99	10	.	.	PUNCT
ajst-23566	100	1	selection	selection	NOUN
ajst-23566	100	2	and	and	CCONJ
ajst-23566	100	3	breeding	breeding	NOUN
ajst-23566	100	4	of	of	ADP
ajst-23566	100	5	the	the	DET
ajst-23566	100	6	bacterial	bacterial	ADJ
ajst-23566	100	7	strain	strain	NOUN
ajst-23566	100	8	of	of	ADP
ajst-23566	100	9	peomycin	peomycin	NOUN
ajst-23566	100	10	-	-	PUNCT
ajst-23566	100	11	producing	produce	VERB
ajst-23566	100	12	bacteria	bacteria	NOUN
ajst-23566	100	13	and	and	CCONJ
ajst-23566	100	14	research	research	NOUN
ajst-23566	100	15	on	on	ADP
ajst-23566	100	16	fermentation	fermentation	NOUN
ajst-23566	100	17	process	process	NOUN
ajst-23566	100	18	.	.	PUNCT
ajst-23566	101	1	tai'an	tai'an	PROPN
ajst-23566	101	2	:	:	PUNCT
ajst-23566	102	1	shandong	shandong	PROPN
ajst-23566	102	2	agricultural	agricultural	PROPN
ajst-23566	102	3	university	university	PROPN
ajst-23566	102	4	.	.	PUNCT
ajst-23566	103	1	[	[	X
ajst-23566	103	2	3	3	X
ajst-23566	103	3	]	]	X
ajst-23566	103	4	enderlin	enderlin	PROPN
ajst-23566	103	5	,	,	PUNCT
ajst-23566	103	6	g.	g.	PROPN
ajst-23566	103	7	,	,	PUNCT
ajst-23566	103	8	morales	morales	PROPN
ajst-23566	103	9	,	,	PUNCT
ajst-23566	103	10	l.	l.	PROPN
ajst-23566	103	11	,	,	PUNCT
ajst-23566	103	12	jacobs	jacobs	PROPN
ajst-23566	103	13	,	,	PUNCT
ajst-23566	103	14	r.	r.	PROPN
ajst-23566	103	15	f.	f.	PROPN
ajst-23566	103	16	,	,	PUNCT
ajst-23566	103	17	et	et	PROPN
ajst-23566	103	18	al	al	PROPN
ajst-23566	103	19	.	.	PUNCT
ajst-23566	103	20	(	(	PUNCT
ajst-23566	103	21	1994	1994	NUM
ajst-23566	103	22	)	)	PUNCT
ajst-23566	103	23	.	.	PUNCT
ajst-23566	104	1	streptomycin	streptomycin	PROPN
ajst-23566	104	2	and	and	CCONJ
ajst-23566	104	3	alternative	alternative	ADJ
ajst-23566	104	4	agents	agent	NOUN
ajst-23566	104	5	for	for	ADP
ajst-23566	104	6	the	the	DET
ajst-23566	104	7	treatment	treatment	NOUN
ajst-23566	104	8	of	of	ADP
ajst-23566	104	9	tularemia	tularemia	NOUN
ajst-23566	104	10	:	:	PUNCT
ajst-23566	104	11	review	review	NOUN
ajst-23566	104	12	of	of	ADP
ajst-23566	104	13	the	the	DET
ajst-23566	104	14	literature	literature	NOUN
ajst-23566	104	15	.	.	PUNCT
ajst-23566	105	1	clinical	clinical	ADJ
ajst-23566	105	2	infectious	infectious	ADJ
ajst-23566	105	3	diseases	disease	NOUN
ajst-23566	105	4	,	,	PUNCT
ajst-23566	105	5	19(1	19(1	NUM
ajst-23566	105	6	)	)	PUNCT
ajst-23566	105	7	,	,	PUNCT
ajst-23566	105	8	42	42	NUM
ajst-23566	105	9	-	-	SYM
ajst-23566	105	10	47	47	NUM
ajst-23566	105	11	.	.	PUNCT
ajst-23566	106	1	[	[	X
ajst-23566	106	2	4	4	NUM
ajst-23566	106	3	]	]	X
ajst-23566	106	4	zhou	zhou	X
ajst-23566	106	5	,	,	PUNCT
ajst-23566	106	6	n.	n.	PROPN
ajst-23566	106	7	,	,	PUNCT
ajst-23566	106	8	wang	wang	PROPN
ajst-23566	106	9	,	,	PUNCT
ajst-23566	106	10	j.	j.	PROPN
ajst-23566	106	11	,	,	PUNCT
ajst-23566	106	12	zhang	zhang	PROPN
ajst-23566	106	13	,	,	PUNCT
ajst-23566	106	14	j.	j.	PROPN
ajst-23566	106	15	,	,	PUNCT
ajst-23566	106	16	et	et	PROPN
ajst-23566	106	17	al	al	PROPN
ajst-23566	106	18	.	.	PROPN
ajst-23566	106	19	(	(	PUNCT
ajst-23566	106	20	2013	2013	NUM
ajst-23566	106	21	)	)	PUNCT
ajst-23566	106	22	.	.	PUNCT
ajst-23566	106	23	selection	selection	NOUN
ajst-23566	106	24	and	and	CCONJ
ajst-23566	106	25	identification	identification	NOUN
ajst-23566	106	26	of	of	ADP
ajst-23566	106	27	streptomycin	streptomycin	PROPN
ajst-23566	106	28	-	-	PUNCT
ajst-23566	106	29	specific	specific	ADJ
ajst-23566	106	30	single	single	ADJ
ajst-23566	106	31	-	-	PUNCT
ajst-23566	106	32	stranded	strand	VERB
ajst-23566	106	33	dna	dna	NOUN
ajst-23566	106	34	aptamers	aptamer	NOUN
ajst-23566	106	35	and	and	CCONJ
ajst-23566	106	36	the	the	DET
ajst-23566	106	37	application	application	NOUN
ajst-23566	106	38	in	in	ADP
ajst-23566	106	39	the	the	DET
ajst-23566	106	40	detection	detection	NOUN
ajst-23566	106	41	of	of	ADP
ajst-23566	106	42	streptomycin	streptomycin	PROPN
ajst-23566	106	43	in	in	ADP
ajst-23566	106	44	honey	honey	PROPN
ajst-23566	106	45	.	.	PUNCT
ajst-23566	107	1	talanta	talanta	PROPN
ajst-23566	107	2	,	,	PUNCT
ajst-23566	107	3	108	108	NUM
ajst-23566	107	4	,	,	PUNCT
ajst-23566	107	5	109	109	NUM
ajst-23566	107	6	-	-	SYM
ajst-23566	107	7	116	116	NUM
ajst-23566	107	8	.	.	PUNCT
ajst-23566	108	1	[	[	X
ajst-23566	108	2	5	5	NUM
ajst-23566	108	3	]	]	X
ajst-23566	108	4	zhang	zhang	PROPN
ajst-23566	108	5	,	,	PUNCT
ajst-23566	108	6	x.	x.	PROPN
ajst-23566	108	7	,	,	PUNCT
ajst-23566	108	8	zhang	zhang	PROPN
ajst-23566	108	9	,	,	PUNCT
ajst-23566	108	10	x.	x.	PROPN
ajst-23566	108	11	,	,	PUNCT
ajst-23566	108	12	wang	wang	PROPN
ajst-23566	108	13	,	,	PUNCT
ajst-23566	108	14	l.	l.	PROPN
ajst-23566	108	15	,	,	PUNCT
ajst-23566	108	16	et	et	PROPN
ajst-23566	108	17	al	al	PROPN
ajst-23566	108	18	.	.	PUNCT
ajst-23566	109	1	(	(	PUNCT
ajst-23566	109	2	2014	2014	NUM
ajst-23566	109	3	)	)	PUNCT
ajst-23566	109	4	.	.	PUNCT
ajst-23566	110	1	progress	progress	NOUN
ajst-23566	110	2	of	of	ADP
ajst-23566	110	3	atmospheric	atmospheric	ADJ
ajst-23566	110	4	pressure	pressure	NOUN
ajst-23566	110	5	room	room	NOUN
ajst-23566	110	6	temperature	temperature	NOUN
ajst-23566	110	7	plasma	plasma	NOUN
ajst-23566	110	8	biomutagenesis	biomutagenesis	NOUN
ajst-23566	110	9	breeding	breeding	NOUN
ajst-23566	110	10	and	and	CCONJ
ajst-23566	110	11	its	its	PRON
ajst-23566	110	12	application	application	NOUN
ajst-23566	110	13	.	.	PUNCT
ajst-23566	111	1	journal	journal	PROPN
ajst-23566	111	2	of	of	ADP
ajst-23566	111	3	chemical	chemical	PROPN
ajst-23566	111	4	engineering	engineering	NOUN
ajst-23566	111	5	,	,	PUNCT
ajst-23566	111	6	65(7	65(7	NUM
ajst-23566	111	7	)	)	PUNCT
ajst-23566	111	8	,	,	PUNCT
ajst-23566	111	9	2676	2676	NUM
ajst-23566	111	10	-	-	SYM
ajst-23566	111	11	2684	2684	NUM
ajst-23566	111	12	.	.	PUNCT
ajst-23566	112	1	[	[	X
ajst-23566	112	2	6	6	NUM
ajst-23566	112	3	]	]	SYM
ajst-23566	112	4	yuan	yuan	PROPN
ajst-23566	112	5	,	,	PUNCT
ajst-23566	112	6	l.	l.	PROPN
ajst-23566	112	7	,	,	PUNCT
ajst-23566	112	8	wang	wang	PROPN
ajst-23566	112	9	,	,	PUNCT
ajst-23566	112	10	l.	l.	PROPN
ajst-23566	112	11	,	,	PUNCT
ajst-23566	112	12	ma	ma	PROPN
ajst-23566	112	13	,	,	PUNCT
ajst-23566	112	14	k.	k.	PROPN
ajst-23566	112	15	,	,	PUNCT
ajst-23566	112	16	et	et	PROPN
ajst-23566	112	17	al	al	PROPN
ajst-23566	112	18	.	.	PUNCT
ajst-23566	112	19	(	(	PUNCT
ajst-23566	112	20	2011	2011	NUM
ajst-23566	112	21	)	)	PUNCT
ajst-23566	112	22	.	.	PUNCT
ajst-23566	113	1	characteristics	characteristic	NOUN
ajst-23566	113	2	of	of	ADP
ajst-23566	113	3	hydrogen	hydrogen	NOUN
ajst-23566	113	4	production	production	NOUN
ajst-23566	113	5	of	of	ADP
ajst-23566	113	6	an	an	DET
ajst-23566	113	7	enterobacter	enterobacter	ADJ
ajst-23566	113	8	aerogenes	aerogene	NOUN
ajst-23566	113	9	mutant	mutant	NOUN
ajst-23566	113	10	generated	generate	VERB
ajst-23566	113	11	by	by	ADP
ajst-23566	113	12	a	a	DET
ajst-23566	113	13	new	new	ADJ
ajst-23566	113	14	atmospheric	atmospheric	NOUN
ajst-23566	113	15	and	and	CCONJ
ajst-23566	113	16	room	room	NOUN
ajst-23566	113	17	temperature	temperature	NOUN
ajst-23566	113	18	plasma	plasma	NOUN
ajst-23566	113	19	(	(	PUNCT
ajst-23566	113	20	artp	artp	ADJ
ajst-23566	113	21	)	)	PUNCT
ajst-23566	113	22	.	.	PUNCT
ajst-23566	114	1	biochemical	biochemical	ADJ
ajst-23566	114	2	engineering	engineering	NOUN
ajst-23566	114	3	journal	journal	NOUN
ajst-23566	114	4	,	,	PUNCT
ajst-23566	114	5	55(1	55(1	NOUN
ajst-23566	114	6	)	)	PUNCT
ajst-23566	114	7	,	,	PUNCT
ajst-23566	114	8	17	17	NUM
ajst-23566	114	9	-	-	SYM
ajst-23566	114	10	22	22	NUM
ajst-23566	114	11	.	.	PUNCT
ajst-23566	115	1	[	[	X
ajst-23566	115	2	7	7	NUM
ajst-23566	115	3	]	]	X
ajst-23566	115	4	zhu	zhu	PROPN
ajst-23566	115	5	,	,	PUNCT
ajst-23566	115	6	c.	c.	PROPN
ajst-23566	115	7	,	,	PUNCT
ajst-23566	115	8	he	he	PRON
ajst-23566	115	9	,	,	PUNCT
ajst-23566	115	10	y.	y.	PROPN
ajst-23566	115	11	,	,	PUNCT
ajst-23566	115	12	du	du	PROPN
ajst-23566	115	13	,	,	PUNCT
ajst-23566	115	14	l.	l.	PROPN
ajst-23566	115	15	,	,	PUNCT
ajst-23566	115	16	et	et	PROPN
ajst-23566	115	17	al	al	PROPN
ajst-23566	115	18	.	.	PUNCT
ajst-23566	115	19	(	(	PUNCT
ajst-23566	115	20	2007	2007	NUM
ajst-23566	115	21	)	)	PUNCT
ajst-23566	115	22	.	.	PUNCT
ajst-23566	116	1	inference	inference	NOUN
ajst-23566	116	2	and	and	CCONJ
ajst-23566	116	3	selection	selection	NOUN
ajst-23566	116	4	of	of	ADP
ajst-23566	116	5	high	high	ADV
ajst-23566	116	6	-	-	PUNCT
ajst-23566	116	7	yielding	yield	VERB
ajst-23566	116	8	strains	strain	NOUN
ajst-23566	116	9	of	of	ADP
ajst-23566	116	10	avilamycin	avilamycin	NOUN
ajst-23566	116	11	.	.	PUNCT
ajst-23566	117	1	journal	journal	NOUN
ajst-23566	117	2	of	of	ADP
ajst-23566	117	3	south	south	PROPN
ajst-23566	117	4	china	china	PROPN
ajst-23566	117	5	university	university	PROPN
ajst-23566	117	6	of	of	ADP
ajst-23566	117	7	technology	technology	NOUN
ajst-23566	117	8	(	(	PUNCT
ajst-23566	117	9	natural	natural	ADJ
ajst-23566	117	10	science	science	NOUN
ajst-23566	117	11	edition	edition	NOUN
ajst-23566	117	12	)	)	PUNCT
ajst-23566	117	13	,	,	PUNCT
ajst-23566	117	14	35(4	35(4	NUM
ajst-23566	117	15	)	)	PUNCT
ajst-23566	117	16	,	,	PUNCT
ajst-23566	117	17	100	100	NUM
ajst-23566	117	18	-	-	SYM
ajst-23566	117	19	105	105	NUM
ajst-23566	117	20	.	.	PUNCT
ajst-23566	118	1	[	[	X
ajst-23566	118	2	8	8	NUM
ajst-23566	118	3	]	]	X
ajst-23566	118	4	gaisser	gaisser	NOUN
ajst-23566	118	5	,	,	PUNCT
ajst-23566	118	6	s.	s.	PROPN
ajst-23566	118	7	,	,	PUNCT
ajst-23566	118	8	trefzer	trefzer	NOUN
ajst-23566	118	9	,	,	PUNCT
ajst-23566	118	10	a.	a.	NOUN
ajst-23566	118	11	,	,	PUNCT
ajst-23566	118	12	stockert	stockert	NOUN
ajst-23566	118	13	,	,	PUNCT
ajst-23566	118	14	s.	s.	PROPN
ajst-23566	118	15	,	,	PUNCT
ajst-23566	118	16	et	et	PROPN
ajst-23566	118	17	al	al	PROPN
ajst-23566	118	18	.	.	PUNCT
ajst-23566	119	1	(	(	PUNCT
ajst-23566	119	2	1997	1997	NUM
ajst-23566	119	3	)	)	PUNCT
ajst-23566	119	4	.	.	PUNCT
ajst-23566	120	1	cloning	cloning	NOUN
ajst-23566	120	2	of	of	ADP
ajst-23566	120	3	an	an	DET
ajst-23566	120	4	avilamycin	avilamycin	ADJ
ajst-23566	120	5	biosynthetic	biosynthetic	ADJ
ajst-23566	120	6	gene	gene	NOUN
ajst-23566	120	7	cluster	cluster	NOUN
ajst-23566	120	8	from	from	ADP
ajst-23566	120	9	streptomyces	streptomyce	NOUN
ajst-23566	120	10	viridochromogenes	viridochromogene	NOUN
ajst-23566	120	11	t57	t57	NOUN
ajst-23566	120	12	.	.	PUNCT
ajst-23566	121	1	journal	journal	PROPN
ajst-23566	121	2	of	of	ADP
ajst-23566	121	3	bacteriology	bacteriology	NOUN
ajst-23566	121	4	,	,	PUNCT
ajst-23566	121	5	179(20	179(20	NUM
ajst-23566	121	6	)	)	PUNCT
ajst-23566	121	7	,	,	PUNCT
ajst-23566	121	8	6271	6271	NUM
ajst-23566	121	9	-	-	SYM
ajst-23566	121	10	6278	6278	NUM
ajst-23566	121	11	.	.	PUNCT
ajst-23566	122	1	[	[	X
ajst-23566	122	2	9	9	NUM
ajst-23566	122	3	]	]	SYM
ajst-23566	122	4	weitnauer	weitnauer	NOUN
ajst-23566	122	5	,	,	PUNCT
ajst-23566	122	6	g.	g.	PROPN
ajst-23566	122	7	,	,	PUNCT
ajst-23566	122	8	mühlenweg	mühlenweg	PROPN
ajst-23566	122	9	,	,	PUNCT
ajst-23566	122	10	a.	a.	NOUN
ajst-23566	122	11	,	,	PUNCT
ajst-23566	122	12	trefzer	trefzer	NOUN
ajst-23566	122	13	,	,	PUNCT
ajst-23566	122	14	a.	a.	NOUN
ajst-23566	122	15	,	,	PUNCT
ajst-23566	122	16	et	et	PROPN
ajst-23566	122	17	al	al	PROPN
ajst-23566	122	18	.	.	PUNCT
ajst-23566	122	19	(	(	PUNCT
ajst-23566	122	20	2001	2001	NUM
ajst-23566	122	21	)	)	PUNCT
ajst-23566	122	22	.	.	PUNCT
ajst-23566	122	23	biosynthesis	biosynthesis	NOUN
ajst-23566	122	24	of	of	ADP
ajst-23566	122	25	the	the	DET
ajst-23566	122	26	orthosomycin	orthosomycin	ADJ
ajst-23566	122	27	antibiotic	antibiotic	ADJ
ajst-23566	122	28	avilamycin	avilamycin	ADV
ajst-23566	122	29	a	a	DET
ajst-23566	122	30	:	:	PUNCT
ajst-23566	122	31	deductions	deduction	NOUN
ajst-23566	122	32	from	from	ADP
ajst-23566	122	33	the	the	DET
ajst-23566	122	34	molecular	molecular	ADJ
ajst-23566	122	35	analysis	analysis	NOUN
ajst-23566	122	36	of	of	ADP
ajst-23566	122	37	the	the	DET
ajst-23566	122	38	avilamycin	avilamycin	ADJ
ajst-23566	122	39	biosynthetic	biosynthetic	ADJ
ajst-23566	122	40	gene	gene	NOUN
ajst-23566	122	41	cluster	cluster	NOUN
ajst-23566	122	42	of	of	ADP
ajst-23566	122	43	streptomyces	streptomyce	NOUN
ajst-23566	122	44	viridochromogenes	viridochromogene	NOUN
ajst-23566	122	45	tü57	tü57	PROPN
ajst-23566	122	46	and	and	CCONJ
ajst-23566	122	47	production	production	NOUN
ajst-23566	122	48	of	of	ADP
ajst-23566	122	49	new	new	ADJ
ajst-23566	122	50	antibiotics	antibiotic	NOUN
ajst-23566	122	51	.	.	PUNCT
ajst-23566	123	1	chemistry	chemistry	NOUN
ajst-23566	123	2	&	&	CCONJ
ajst-23566	123	3	biology	biology	NOUN
ajst-23566	123	4	,	,	PUNCT
ajst-23566	123	5	8(6	8(6	NUM
ajst-23566	123	6	)	)	PUNCT
ajst-23566	123	7	,	,	PUNCT
ajst-23566	123	8	569	569	NUM
ajst-23566	123	9	-	-	SYM
ajst-23566	123	10	581	581	NUM
ajst-23566	123	11	.	.	PUNCT
ajst-23566	124	1	[	[	X
ajst-23566	124	2	10	10	NUM
ajst-23566	124	3	]	]	X
ajst-23566	124	4	zhu	zhu	PROPN
ajst-23566	124	5	,	,	PUNCT
ajst-23566	124	6	c.	c.	PROPN
ajst-23566	124	7	h.	h.	PROPN
ajst-23566	124	8	,	,	PUNCT
ajst-23566	124	9	lu	lu	PROPN
ajst-23566	124	10	,	,	PUNCT
ajst-23566	124	11	f.	f.	PROPN
ajst-23566	124	12	p.	p.	PROPN
ajst-23566	124	13	,	,	PUNCT
ajst-23566	124	14	he	he	PRON
ajst-23566	124	15	,	,	PUNCT
ajst-23566	124	16	y.	y.	PROPN
ajst-23566	124	17	n.	n.	PROPN
ajst-23566	124	18	,	,	PUNCT
ajst-23566	124	19	et	et	PROPN
ajst-23566	124	20	al	al	PROPN
ajst-23566	124	21	.	.	PUNCT
ajst-23566	124	22	(	(	PUNCT
ajst-23566	124	23	2007	2007	NUM
ajst-23566	124	24	)	)	PUNCT
ajst-23566	124	25	.	.	PUNCT
ajst-23566	125	1	regulation	regulation	NOUN
ajst-23566	125	2	of	of	ADP
ajst-23566	125	3	avilamycin	avilamycin	NOUN
ajst-23566	125	4	biosynthesis	biosynthesis	VERB
ajst-23566	125	5	in	in	ADP
ajst-23566	125	6	streptomyces	streptomyce	NOUN
ajst-23566	125	7	viridochromogenes	viridochromogene	NOUN
ajst-23566	125	8	:	:	PUNCT
ajst-23566	125	9	105	105	NUM
ajst-23566	125	10	effects	effect	NOUN
ajst-23566	125	11	of	of	ADP
ajst-23566	125	12	glucose	glucose	NOUN
ajst-23566	125	13	,	,	PUNCT
ajst-23566	125	14	ammonium	ammonium	NOUN
ajst-23566	125	15	ion	ion	NOUN
ajst-23566	125	16	,	,	PUNCT
ajst-23566	125	17	and	and	CCONJ
ajst-23566	125	18	inorganic	inorganic	ADJ
ajst-23566	125	19	phosphate	phosphate	NOUN
ajst-23566	125	20	.	.	PUNCT
ajst-23566	126	1	applied	apply	VERB
ajst-23566	126	2	microbiology	microbiology	NOUN
ajst-23566	126	3	biotechnology	biotechnology	NOUN
ajst-23566	126	4	,	,	PUNCT
ajst-23566	126	5	73(5	73(5	NUM
ajst-23566	126	6	)	)	PUNCT
ajst-23566	126	7	,	,	PUNCT
ajst-23566	126	8	1031	1031	NUM
ajst-23566	126	9	-	-	SYM
ajst-23566	126	10	1038	1038	NUM
ajst-23566	126	11	.	.	PUNCT
ajst-23566	127	1	[	[	X
ajst-23566	127	2	11	11	NUM
ajst-23566	127	3	]	]	PUNCT
ajst-23566	127	4	butler	butler	NOUN
ajst-23566	127	5	,	,	PUNCT
ajst-23566	127	6	m.	m.	PROPN
ajst-23566	127	7	j.	j.	PROPN
ajst-23566	127	8	,	,	PUNCT
ajst-23566	127	9	bruheim	bruheim	PROPN
ajst-23566	127	10	,	,	PUNCT
ajst-23566	127	11	p.	p.	NOUN
ajst-23566	127	12	,	,	PUNCT
ajst-23566	127	13	jovetic	jovetic	PROPN
ajst-23566	127	14	,	,	PUNCT
ajst-23566	127	15	s.	s.	PROPN
ajst-23566	127	16	,	,	PUNCT
ajst-23566	127	17	et	et	PROPN
ajst-23566	127	18	al	al	PROPN
ajst-23566	127	19	.	.	PUNCT
ajst-23566	127	20	(	(	PUNCT
ajst-23566	127	21	2002	2002	NUM
ajst-23566	127	22	)	)	PUNCT
ajst-23566	127	23	.	.	PUNCT
ajst-23566	128	1	engineering	engineering	NOUN
ajst-23566	128	2	of	of	ADP
ajst-23566	128	3	primary	primary	ADJ
ajst-23566	128	4	carbon	carbon	NOUN
ajst-23566	128	5	metabolism	metabolism	NOUN
ajst-23566	128	6	for	for	ADP
ajst-23566	128	7	improved	improve	VERB
ajst-23566	128	8	antibiotic	antibiotic	ADJ
ajst-23566	128	9	production	production	NOUN
ajst-23566	128	10	in	in	ADP
ajst-23566	128	11	streptomyces	streptomyce	NOUN
ajst-23566	128	12	lividans	lividan	NOUN
ajst-23566	128	13	.	.	PUNCT
ajst-23566	129	1	applied	apply	VERB
ajst-23566	129	2	and	and	CCONJ
ajst-23566	129	3	environmental	environmental	ADJ
ajst-23566	129	4	microbiology	microbiology	NOUN
ajst-23566	129	5	,	,	PUNCT
ajst-23566	129	6	68(10	68(10	NUM
ajst-23566	129	7	)	)	PUNCT
ajst-23566	129	8	,	,	PUNCT
ajst-23566	129	9	4731	4731	NUM
ajst-23566	129	10	-	-	SYM
ajst-23566	129	11	4739	4739	NUM
ajst-23566	129	12	.	.	PUNCT