id	sid	tid	token	lemma	pos
ajst-25612	1	1	academic	academic	ADJ
ajst-25612	1	2	journal	journal	NOUN
ajst-25612	1	3	of	of	ADP
ajst-25612	1	4	science	science	NOUN
ajst-25612	1	5	and	and	CCONJ
ajst-25612	1	6	technology	technology	NOUN
ajst-25612	1	7	issn	issn	NOUN
ajst-25612	1	8	:	:	PUNCT
ajst-25612	1	9	2771	2771	NUM
ajst-25612	1	10	-	-	SYM
ajst-25612	1	11	3032	3032	NUM
ajst-25612	1	12	|	|	NOUN
ajst-25612	1	13	vol	vol	NOUN
ajst-25612	1	14	.	.	PROPN
ajst-25612	2	1	12	12	NUM
ajst-25612	2	2	,	,	PUNCT
ajst-25612	2	3	no	no	INTJ
ajst-25612	2	4	.	.	NOUN
ajst-25612	2	5	2	2	NUM
ajst-25612	2	6	,	,	PUNCT
ajst-25612	2	7	2024	2024	NUM
ajst-25612	2	8	170	170	NUM
ajst-25612	2	9	research	research	NOUN
ajst-25612	2	10	progress	progress	NOUN
ajst-25612	2	11	on	on	ADP
ajst-25612	2	12	the	the	DET
ajst-25612	2	13	effects	effect	NOUN
ajst-25612	2	14	of	of	ADP
ajst-25612	2	15	pi3k	pi3k	PROPN
ajst-25612	2	16	/	/	SYM
ajst-25612	2	17	akt	akt	PROPN
ajst-25612	2	18	pathway	pathway	NOUN
ajst-25612	2	19	on	on	ADP
ajst-25612	2	20	immune	immune	ADJ
ajst-25612	2	21	escape	escape	NOUN
ajst-25612	2	22	tianran	tianran	PROPN
ajst-25612	2	23	wang	wang	PROPN
ajst-25612	2	24	*	*	PUNCT
ajst-25612	2	25	college	college	PROPN
ajst-25612	2	26	of	of	ADP
ajst-25612	2	27	life	life	NOUN
ajst-25612	2	28	sciences	sciences	PROPN
ajst-25612	2	29	,	,	PUNCT
ajst-25612	2	30	liaoning	liaoning	NOUN
ajst-25612	2	31	normal	normal	ADJ
ajst-25612	2	32	university	university	PROPN
ajst-25612	2	33	,	,	PUNCT
ajst-25612	2	34	dalian	dalian	PROPN
ajst-25612	2	35	,	,	PUNCT
ajst-25612	2	36	116029	116029	NUM
ajst-25612	2	37	,	,	PUNCT
ajst-25612	2	38	china	china	PROPN
ajst-25612	2	39	*	*	PUNCT
ajst-25612	2	40	corresponding	correspond	VERB
ajst-25612	2	41	author	author	NOUN
ajst-25612	2	42	email	email	NOUN
ajst-25612	2	43	:	:	PUNCT
ajst-25612	2	44	wangtianran612@163.com	wangtianran612@163.com	X
ajst-25612	2	45	abstract	abstract	NOUN
ajst-25612	2	46	:	:	PUNCT
ajst-25612	2	47	the	the	DET
ajst-25612	2	48	pi3k	pi3k	PROPN
ajst-25612	2	49	/	/	SYM
ajst-25612	2	50	akt	akt	PROPN
ajst-25612	2	51	pathway	pathway	NOUN
ajst-25612	2	52	can	can	AUX
ajst-25612	2	53	promote	promote	VERB
ajst-25612	2	54	immune	immune	ADJ
ajst-25612	2	55	escape	escape	NOUN
ajst-25612	2	56	in	in	ADP
ajst-25612	2	57	tumors	tumor	NOUN
ajst-25612	2	58	,	,	PUNCT
ajst-25612	2	59	making	make	VERB
ajst-25612	2	60	cancer	cancer	NOUN
ajst-25612	2	61	cells	cell	NOUN
ajst-25612	2	62	more	more	ADV
ajst-25612	2	63	difficult	difficult	ADJ
ajst-25612	2	64	for	for	SCONJ
ajst-25612	2	65	the	the	DET
ajst-25612	2	66	immune	immune	ADJ
ajst-25612	2	67	system	system	NOUN
ajst-25612	2	68	to	to	PART
ajst-25612	2	69	attack	attack	VERB
ajst-25612	2	70	.	.	PUNCT
ajst-25612	3	1	it	it	PRON
ajst-25612	3	2	is	be	AUX
ajst-25612	3	3	usually	usually	ADV
ajst-25612	3	4	possible	possible	ADJ
ajst-25612	3	5	to	to	PART
ajst-25612	3	6	regulate	regulate	VERB
ajst-25612	3	7	the	the	DET
ajst-25612	3	8	number	number	NOUN
ajst-25612	3	9	and	and	CCONJ
ajst-25612	3	10	function	function	NOUN
ajst-25612	3	11	of	of	ADP
ajst-25612	3	12	immune	immune	ADJ
ajst-25612	3	13	cells	cell	NOUN
ajst-25612	3	14	by	by	ADP
ajst-25612	3	15	inhibiting	inhibit	VERB
ajst-25612	3	16	apoptosis	apoptosis	NOUN
ajst-25612	3	17	and	and	CCONJ
ajst-25612	3	18	t	t	NOUN
ajst-25612	3	19	cell	cell	NOUN
ajst-25612	3	20	activation	activation	NOUN
ajst-25612	3	21	,	,	PUNCT
ajst-25612	3	22	and	and	CCONJ
ajst-25612	3	23	generate	generate	VERB
ajst-25612	3	24	immune	immune	ADJ
ajst-25612	3	25	escape	escape	NOUN
ajst-25612	3	26	mutations	mutation	NOUN
ajst-25612	3	27	to	to	PART
ajst-25612	3	28	make	make	VERB
ajst-25612	3	29	cancer	cancer	NOUN
ajst-25612	3	30	cells	cell	NOUN
ajst-25612	3	31	more	more	ADV
ajst-25612	3	32	resistant	resistant	ADJ
ajst-25612	3	33	to	to	ADP
ajst-25612	3	34	immune	immune	ADJ
ajst-25612	3	35	monitoring	monitoring	NOUN
ajst-25612	3	36	.	.	PUNCT
ajst-25612	4	1	in	in	ADP
ajst-25612	4	2	-	-	PUNCT
ajst-25612	4	3	depth	depth	NOUN
ajst-25612	4	4	understanding	understanding	NOUN
ajst-25612	4	5	of	of	ADP
ajst-25612	4	6	the	the	DET
ajst-25612	4	7	role	role	NOUN
ajst-25612	4	8	of	of	ADP
ajst-25612	4	9	pi3k	pi3k	PROPN
ajst-25612	4	10	/	/	SYM
ajst-25612	4	11	akt	akt	PROPN
ajst-25612	4	12	pathway	pathway	NOUN
ajst-25612	4	13	in	in	ADP
ajst-25612	4	14	immune	immune	ADJ
ajst-25612	4	15	escape	escape	NOUN
ajst-25612	4	16	will	will	AUX
ajst-25612	4	17	help	help	VERB
ajst-25612	4	18	to	to	PART
ajst-25612	4	19	reveal	reveal	VERB
ajst-25612	4	20	the	the	DET
ajst-25612	4	21	mechanism	mechanism	NOUN
ajst-25612	4	22	of	of	ADP
ajst-25612	4	23	tumor	tumor	NOUN
ajst-25612	4	24	development	development	NOUN
ajst-25612	4	25	,	,	PUNCT
ajst-25612	4	26	improve	improve	VERB
ajst-25612	4	27	the	the	DET
ajst-25612	4	28	effectiveness	effectiveness	NOUN
ajst-25612	4	29	of	of	ADP
ajst-25612	4	30	cancer	cancer	NOUN
ajst-25612	4	31	treatment	treatment	NOUN
ajst-25612	4	32	.	.	PUNCT
ajst-25612	5	1	development	development	NOUN
ajst-25612	5	2	,	,	PUNCT
ajst-25612	5	3	improve	improve	VERB
ajst-25612	5	4	the	the	DET
ajst-25612	5	5	effectiveness	effectiveness	NOUN
ajst-25612	5	6	of	of	ADP
ajst-25612	5	7	cancer	cancer	NOUN
ajst-25612	5	8	treatment	treatment	NOUN
ajst-25612	5	9	,	,	PUNCT
ajst-25612	5	10	and	and	CCONJ
ajst-25612	5	11	restore	restore	VERB
ajst-25612	5	12	the	the	DET
ajst-25612	5	13	immune	immune	ADJ
ajst-25612	5	14	system	system	NOUN
ajst-25612	5	15	's	's	PART
ajst-25612	5	16	monitoring	monitoring	NOUN
ajst-25612	5	17	and	and	CCONJ
ajst-25612	5	18	attack	attack	NOUN
ajst-25612	5	19	on	on	ADP
ajst-25612	5	20	cancer	cancer	NOUN
ajst-25612	5	21	cells	cell	NOUN
ajst-25612	5	22	by	by	ADP
ajst-25612	5	23	inhibiting	inhibit	VERB
ajst-25612	5	24	the	the	DET
ajst-25612	5	25	activity	activity	NOUN
ajst-25612	5	26	of	of	ADP
ajst-25612	5	27	pi3k	pi3k	PROPN
ajst-25612	5	28	/	/	SYM
ajst-25612	5	29	akt	akt	PROPN
ajst-25612	5	30	.	.	PUNCT
ajst-25612	6	1	in	in	ADP
ajst-25612	6	2	this	this	DET
ajst-25612	6	3	review	review	NOUN
ajst-25612	6	4	,	,	PUNCT
ajst-25612	6	5	we	we	PRON
ajst-25612	6	6	review	review	VERB
ajst-25612	6	7	the	the	DET
ajst-25612	6	8	research	research	NOUN
ajst-25612	6	9	progress	progress	NOUN
ajst-25612	6	10	on	on	ADP
ajst-25612	6	11	the	the	DET
ajst-25612	6	12	effects	effect	NOUN
ajst-25612	6	13	of	of	ADP
ajst-25612	6	14	g	g	NOUN
ajst-25612	6	15	protein	protein	NOUN
ajst-25612	6	16	-	-	PUNCT
ajst-25612	6	17	coupled	couple	VERB
ajst-25612	6	18	receptor	receptor	NOUN
ajst-25612	6	19	-	-	PUNCT
ajst-25612	6	20	activated	activate	VERB
ajst-25612	6	21	pi3k	pi3k	PROPN
ajst-25612	6	22	/	/	SYM
ajst-25612	6	23	akt	akt	PROPN
ajst-25612	6	24	pathway	pathway	NOUN
ajst-25612	6	25	on	on	ADP
ajst-25612	6	26	immune	immune	ADJ
ajst-25612	6	27	escape	escape	NOUN
ajst-25612	6	28	.	.	PUNCT
ajst-25612	7	1	this	this	DET
ajst-25612	7	2	review	review	NOUN
ajst-25612	7	3	aims	aim	VERB
ajst-25612	7	4	to	to	PART
ajst-25612	7	5	summarize	summarize	VERB
ajst-25612	7	6	domestic	domestic	ADJ
ajst-25612	7	7	and	and	CCONJ
ajst-25612	7	8	international	international	ADJ
ajst-25612	7	9	studies	study	NOUN
ajst-25612	7	10	that	that	PRON
ajst-25612	7	11	reveal	reveal	VERB
ajst-25612	7	12	how	how	SCONJ
ajst-25612	7	13	the	the	DET
ajst-25612	7	14	pi3k	pi3k	PROPN
ajst-25612	7	15	/	/	SYM
ajst-25612	7	16	akt	akt	PROPN
ajst-25612	7	17	pathway	pathway	NOUN
ajst-25612	7	18	plays	play	VERB
ajst-25612	7	19	a	a	DET
ajst-25612	7	20	key	key	ADJ
ajst-25612	7	21	role	role	NOUN
ajst-25612	7	22	in	in	ADP
ajst-25612	7	23	immune	immune	ADJ
ajst-25612	7	24	escape	escape	NOUN
ajst-25612	7	25	,	,	PUNCT
ajst-25612	7	26	and	and	CCONJ
ajst-25612	7	27	through	through	ADP
ajst-25612	7	28	in	in	ADP
ajst-25612	7	29	-	-	PUNCT
ajst-25612	7	30	depth	depth	NOUN
ajst-25612	7	31	understanding	understanding	NOUN
ajst-25612	7	32	of	of	ADP
ajst-25612	7	33	the	the	DET
ajst-25612	7	34	role	role	NOUN
ajst-25612	7	35	of	of	ADP
ajst-25612	7	36	the	the	DET
ajst-25612	7	37	pi3k	pi3k	PROPN
ajst-25612	7	38	/	/	SYM
ajst-25612	7	39	akt	akt	PROPN
ajst-25612	7	40	pathway	pathway	NOUN
ajst-25612	7	41	in	in	ADP
ajst-25612	7	42	immune	immune	ADJ
ajst-25612	7	43	escape	escape	NOUN
ajst-25612	7	44	.	.	PUNCT
ajst-25612	8	1	this	this	DET
ajst-25612	8	2	review	review	NOUN
ajst-25612	8	3	aims	aim	VERB
ajst-25612	8	4	to	to	PART
ajst-25612	8	5	summarize	summarize	VERB
ajst-25612	8	6	domestic	domestic	ADJ
ajst-25612	8	7	and	and	CCONJ
ajst-25612	8	8	international	international	ADJ
ajst-25612	8	9	studies	study	NOUN
ajst-25612	8	10	that	that	PRON
ajst-25612	8	11	reveal	reveal	VERB
ajst-25612	8	12	how	how	SCONJ
ajst-25612	8	13	the	the	DET
ajst-25612	8	14	pi3k	pi3k	PROPN
ajst-25612	8	15	/	/	SYM
ajst-25612	8	16	akt	akt	PROPN
ajst-25612	8	17	pathway	pathway	NOUN
ajst-25612	8	18	plays	play	VERB
ajst-25612	8	19	a	a	DET
ajst-25612	8	20	key	key	ADJ
ajst-25612	8	21	role	role	NOUN
ajst-25612	8	22	in	in	ADP
ajst-25612	8	23	immune	immune	ADJ
ajst-25612	8	24	escape	escape	NOUN
ajst-25612	8	25	,	,	PUNCT
ajst-25612	8	26	and	and	CCONJ
ajst-25612	8	27	through	through	ADP
ajst-25612	8	28	in	in	ADP
ajst-25612	8	29	-	-	PUNCT
ajst-25612	8	30	depth	depth	NOUN
ajst-25612	8	31	understanding	understanding	NOUN
ajst-25612	8	32	of	of	ADP
ajst-25612	8	33	the	the	DET
ajst-25612	8	34	molecular	molecular	ADJ
ajst-25612	8	35	mechanism	mechanism	NOUN
ajst-25612	8	36	,	,	PUNCT
ajst-25612	8	37	new	new	ADJ
ajst-25612	8	38	therapeutic	therapeutic	ADJ
ajst-25612	8	39	targets	target	NOUN
ajst-25612	8	40	can	can	AUX
ajst-25612	8	41	be	be	AUX
ajst-25612	8	42	identified	identify	VERB
ajst-25612	8	43	.	.	PUNCT
ajst-25612	9	1	scientists	scientist	NOUN
ajst-25612	9	2	from	from	ADP
ajst-25612	9	3	abroad	abroad	ADV
ajst-25612	9	4	have	have	AUX
ajst-25612	9	5	explored	explore	VERB
ajst-25612	9	6	various	various	ADJ
ajst-25612	9	7	cancer	cancer	NOUN
ajst-25612	9	8	forms	form	NOUN
ajst-25612	9	9	,	,	PUNCT
ajst-25612	9	10	such	such	ADJ
ajst-25612	9	11	as	as	ADP
ajst-25612	9	12	lung	lung	NOUN
ajst-25612	9	13	,	,	PUNCT
ajst-25612	9	14	ovarian	ovarian	ADJ
ajst-25612	9	15	,	,	PUNCT
ajst-25612	9	16	and	and	CCONJ
ajst-25612	9	17	endometrial	endometrial	ADJ
ajst-25612	9	18	cancers	cancer	NOUN
ajst-25612	9	19	,	,	PUNCT
ajst-25612	9	20	etc	etc	X
ajst-25612	9	21	.	.	X
ajst-25612	9	22	,	,	PUNCT
ajst-25612	9	23	so	so	SCONJ
ajst-25612	9	24	as	as	SCONJ
ajst-25612	9	25	to	to	PART
ajst-25612	9	26	provide	provide	VERB
ajst-25612	9	27	targeted	target	VERB
ajst-25612	9	28	treatment	treatment	NOUN
ajst-25612	9	29	strategies	strategy	NOUN
ajst-25612	9	30	and	and	CCONJ
ajst-25612	9	31	increase	increase	VERB
ajst-25612	9	32	the	the	DET
ajst-25612	9	33	applicability	applicability	NOUN
ajst-25612	9	34	of	of	ADP
ajst-25612	9	35	immunotherapy	immunotherapy	NOUN
ajst-25612	9	36	for	for	ADP
ajst-25612	9	37	different	different	ADJ
ajst-25612	9	38	cancers	cancer	NOUN
ajst-25612	9	39	;	;	PUNCT
ajst-25612	9	40	by	by	ADP
ajst-25612	9	41	studying	study	VERB
ajst-25612	9	42	the	the	DET
ajst-25612	9	43	role	role	NOUN
ajst-25612	9	44	of	of	ADP
ajst-25612	9	45	pi3k	pi3k	PROPN
ajst-25612	9	46	/	/	SYM
ajst-25612	9	47	akt	akt	PROPN
ajst-25612	9	48	pathway	pathway	NOUN
ajst-25612	9	49	,	,	PUNCT
ajst-25612	9	50	we	we	PRON
ajst-25612	9	51	can	can	AUX
ajst-25612	9	52	explore	explore	VERB
ajst-25612	9	53	the	the	DET
ajst-25612	9	54	potential	potential	ADJ
ajst-25612	9	55	application	application	NOUN
ajst-25612	9	56	of	of	ADP
ajst-25612	9	57	pi3k	pi3k	PROPN
ajst-25612	9	58	/	/	SYM
ajst-25612	9	59	akt	akt	PROPN
ajst-25612	9	60	pathway	pathway	NOUN
ajst-25612	9	61	for	for	ADP
ajst-25612	9	62	different	different	ADJ
ajst-25612	9	63	cancers	cancer	NOUN
ajst-25612	9	64	.	.	PUNCT
ajst-25612	10	1	by	by	ADP
ajst-25612	10	2	studying	study	VERB
ajst-25612	10	3	the	the	DET
ajst-25612	10	4	role	role	NOUN
ajst-25612	10	5	of	of	ADP
ajst-25612	10	6	pi3k	pi3k	PROPN
ajst-25612	10	7	/	/	SYM
ajst-25612	10	8	akt	akt	PROPN
ajst-25612	10	9	pathway	pathway	NOUN
ajst-25612	10	10	,	,	PUNCT
ajst-25612	10	11	we	we	PRON
ajst-25612	10	12	can	can	AUX
ajst-25612	10	13	explore	explore	VERB
ajst-25612	10	14	the	the	DET
ajst-25612	10	15	potential	potential	ADJ
ajst-25612	10	16	application	application	NOUN
ajst-25612	10	17	of	of	ADP
ajst-25612	10	18	existing	exist	VERB
ajst-25612	10	19	drugs	drug	NOUN
ajst-25612	10	20	or	or	CCONJ
ajst-25612	10	21	new	new	ADJ
ajst-25612	10	22	drugs	drug	NOUN
ajst-25612	10	23	in	in	ADP
ajst-25612	10	24	immunotherapy	immunotherapy	NOUN
ajst-25612	10	25	,	,	PUNCT
ajst-25612	10	26	so	so	SCONJ
ajst-25612	10	27	as	as	SCONJ
ajst-25612	10	28	to	to	PART
ajst-25612	10	29	improve	improve	VERB
ajst-25612	10	30	the	the	DET
ajst-25612	10	31	diversity	diversity	NOUN
ajst-25612	10	32	of	of	ADP
ajst-25612	10	33	treatment	treatment	NOUN
ajst-25612	10	34	.	.	PUNCT
ajst-25612	11	1	techniques	technique	NOUN
ajst-25612	11	2	are	be	AUX
ajst-25612	11	3	combined	combine	VERB
ajst-25612	11	4	with	with	ADP
ajst-25612	11	5	clinical	clinical	ADJ
ajst-25612	11	6	data	datum	NOUN
ajst-25612	11	7	to	to	PART
ajst-25612	11	8	discover	discover	VERB
ajst-25612	11	9	associations	association	NOUN
ajst-25612	11	10	between	between	ADP
ajst-25612	11	11	the	the	DET
ajst-25612	11	12	pi3k	pi3k	PROPN
ajst-25612	11	13	/	/	SYM
ajst-25612	11	14	akt	akt	PROPN
ajst-25612	11	15	pathway	pathway	NOUN
ajst-25612	11	16	and	and	CCONJ
ajst-25612	11	17	treatment	treatment	NOUN
ajst-25612	11	18	response	response	NOUN
ajst-25612	11	19	in	in	ADP
ajst-25612	11	20	patients	patient	NOUN
ajst-25612	11	21	to	to	PART
ajst-25612	11	22	support	support	VERB
ajst-25612	11	23	personalized	personalized	ADJ
ajst-25612	11	24	medicine	medicine	NOUN
ajst-25612	11	25	.	.	PUNCT
ajst-25612	12	1	current	current	ADJ
ajst-25612	12	2	studies	study	NOUN
ajst-25612	12	3	have	have	AUX
ajst-25612	12	4	found	find	VERB
ajst-25612	12	5	that	that	SCONJ
ajst-25612	12	6	the	the	DET
ajst-25612	12	7	pi3k	pi3k	PROPN
ajst-25612	12	8	/	/	SYM
ajst-25612	12	9	akt	akt	PROPN
ajst-25612	12	10	pathway	pathway	NOUN
ajst-25612	12	11	is	be	AUX
ajst-25612	12	12	a	a	DET
ajst-25612	12	13	key	key	ADJ
ajst-25612	12	14	mechanism	mechanism	NOUN
ajst-25612	12	15	for	for	ADP
ajst-25612	12	16	immune	immune	ADJ
ajst-25612	12	17	monitoring	monitoring	NOUN
ajst-25612	12	18	of	of	ADP
ajst-25612	12	19	tumor	tumor	NOUN
ajst-25612	12	20	cell	cell	NOUN
ajst-25612	12	21	escape	escape	NOUN
ajst-25612	12	22	,	,	PUNCT
ajst-25612	12	23	and	and	CCONJ
ajst-25612	12	24	in	in	ADP
ajst-25612	12	25	-	-	PUNCT
ajst-25612	12	26	depth	depth	NOUN
ajst-25612	12	27	study	study	NOUN
ajst-25612	12	28	of	of	ADP
ajst-25612	12	29	its	its	PRON
ajst-25612	12	30	role	role	NOUN
ajst-25612	12	31	is	be	AUX
ajst-25612	12	32	expected	expect	VERB
ajst-25612	12	33	to	to	PART
ajst-25612	12	34	improve	improve	VERB
ajst-25612	12	35	the	the	DET
ajst-25612	12	36	quality	quality	NOUN
ajst-25612	12	37	of	of	ADP
ajst-25612	12	38	treatment	treatment	NOUN
ajst-25612	12	39	.	.	PUNCT
ajst-25612	13	1	current	current	ADJ
ajst-25612	13	2	studies	study	NOUN
ajst-25612	13	3	have	have	AUX
ajst-25612	13	4	found	find	VERB
ajst-25612	13	5	that	that	SCONJ
ajst-25612	13	6	the	the	DET
ajst-25612	13	7	pi3k	pi3k	PROPN
ajst-25612	13	8	/	/	SYM
ajst-25612	13	9	akt	akt	PROPN
ajst-25612	13	10	pathway	pathway	NOUN
ajst-25612	13	11	is	be	AUX
ajst-25612	13	12	a	a	DET
ajst-25612	13	13	key	key	ADJ
ajst-25612	13	14	mechanism	mechanism	NOUN
ajst-25612	13	15	for	for	ADP
ajst-25612	13	16	immune	immune	ADJ
ajst-25612	13	17	monitoring	monitoring	NOUN
ajst-25612	13	18	of	of	ADP
ajst-25612	13	19	tumor	tumor	NOUN
ajst-25612	13	20	cell	cell	NOUN
ajst-25612	13	21	escape	escape	NOUN
ajst-25612	13	22	,	,	PUNCT
ajst-25612	13	23	and	and	CCONJ
ajst-25612	13	24	in	in	ADP
ajst-25612	13	25	-	-	PUNCT
ajst-25612	13	26	depth	depth	NOUN
ajst-25612	13	27	study	study	NOUN
ajst-25612	13	28	of	of	ADP
ajst-25612	13	29	its	its	PRON
ajst-25612	13	30	role	role	NOUN
ajst-25612	13	31	is	be	AUX
ajst-25612	13	32	expected	expect	VERB
ajst-25612	13	33	to	to	PART
ajst-25612	13	34	improve	improve	VERB
ajst-25612	13	35	current	current	ADJ
ajst-25612	13	36	immunotherapy	immunotherapy	NOUN
ajst-25612	13	37	strategies	strategy	NOUN
ajst-25612	13	38	and	and	CCONJ
ajst-25612	13	39	improve	improve	VERB
ajst-25612	13	40	patient	patient	ADJ
ajst-25612	13	41	survival	survival	NOUN
ajst-25612	13	42	.	.	PUNCT
ajst-25612	14	1	in	in	ADP
ajst-25612	14	2	the	the	DET
ajst-25612	14	3	future	future	NOUN
ajst-25612	14	4	,	,	PUNCT
ajst-25612	14	5	whether	whether	SCONJ
ajst-25612	14	6	there	there	PRON
ajst-25612	14	7	are	be	VERB
ajst-25612	14	8	new	new	ADJ
ajst-25612	14	9	therapeutic	therapeutic	ADJ
ajst-25612	14	10	opportunities	opportunity	NOUN
ajst-25612	14	11	for	for	ADP
ajst-25612	14	12	pi3k	pi3k	PROPN
ajst-25612	14	13	/	/	SYM
ajst-25612	14	14	akt	akt	PROPN
ajst-25612	14	15	pathway	pathway	NOUN
ajst-25612	14	16	in	in	ADP
ajst-25612	14	17	immune	immune	ADJ
ajst-25612	14	18	escape	escape	NOUN
ajst-25612	14	19	studies	study	NOUN
ajst-25612	14	20	,	,	PUNCT
ajst-25612	14	21	so	so	SCONJ
ajst-25612	14	22	as	as	SCONJ
ajst-25612	14	23	to	to	PART
ajst-25612	14	24	help	help	VERB
ajst-25612	14	25	optimize	optimize	VERB
ajst-25612	14	26	cancer	cancer	NOUN
ajst-25612	14	27	treatment	treatment	NOUN
ajst-25612	14	28	strategies	strategy	NOUN
ajst-25612	14	29	,	,	PUNCT
ajst-25612	14	30	improve	improve	VERB
ajst-25612	14	31	the	the	DET
ajst-25612	14	32	efficacy	efficacy	NOUN
ajst-25612	14	33	of	of	ADP
ajst-25612	14	34	immunotherapy	immunotherapy	NOUN
ajst-25612	14	35	in	in	ADP
ajst-25612	14	36	future	future	NOUN
ajst-25612	14	37	,	,	PUNCT
ajst-25612	14	38	whether	whether	SCONJ
ajst-25612	14	39	there	there	PRON
ajst-25612	14	40	are	be	VERB
ajst-25612	14	41	new	new	ADJ
ajst-25612	14	42	therapeutic	therapeutic	ADJ
ajst-25612	14	43	opportunities	opportunity	NOUN
ajst-25612	14	44	for	for	ADP
ajst-25612	14	45	pi3k	pi3k	PROPN
ajst-25612	14	46	/	/	SYM
ajst-25612	14	47	akt	akt	PROPN
ajst-25612	14	48	pathway	pathway	NOUN
ajst-25612	14	49	in	in	ADP
ajst-25612	14	50	immune	immune	ADJ
ajst-25612	14	51	escape	escape	NOUN
ajst-25612	14	52	studies	study	NOUN
ajst-25612	14	53	,	,	PUNCT
ajst-25612	14	54	so	so	SCONJ
ajst-25612	14	55	as	as	SCONJ
ajst-25612	14	56	to	to	PART
ajst-25612	14	57	help	help	VERB
ajst-25612	14	58	optimize	optimize	VERB
ajst-25612	14	59	cancer	cancer	NOUN
ajst-25612	14	60	treatment	treatment	NOUN
ajst-25612	14	61	strategies	strategy	NOUN
ajst-25612	14	62	,	,	PUNCT
ajst-25612	14	63	improve	improve	VERB
ajst-25612	14	64	the	the	DET
ajst-25612	14	65	efficacy	efficacy	NOUN
ajst-25612	14	66	of	of	ADP
ajst-25612	14	67	immunotherapy	immunotherapy	NOUN
ajst-25612	14	68	,	,	PUNCT
ajst-25612	14	69	and	and	CCONJ
ajst-25612	14	70	improve	improve	VERB
ajst-25612	14	71	patient	patient	ADJ
ajst-25612	14	72	treatment	treatment	NOUN
ajst-25612	14	73	outcomes	outcome	NOUN
ajst-25612	14	74	.	.	PUNCT
ajst-25612	15	1	keywords	keyword	NOUN
ajst-25612	15	2	:	:	PUNCT
ajst-25612	15	3	pi3k	pi3k	PROPN
ajst-25612	15	4	/	/	SYM
ajst-25612	15	5	akt	akt	PROPN
ajst-25612	15	6	pathway	pathway	NOUN
ajst-25612	15	7	;	;	PUNCT
ajst-25612	15	8	immune	immune	ADJ
ajst-25612	15	9	escape	escape	NOUN
ajst-25612	15	10	;	;	PUNCT
ajst-25612	15	11	cell	cell	NOUN
ajst-25612	15	12	apoptosis	apoptosis	NOUN
ajst-25612	15	13	;	;	PUNCT
ajst-25612	15	14	t	t	NOUN
ajst-25612	15	15	cell	cell	NOUN
ajst-25612	15	16	activation	activation	NOUN
ajst-25612	15	17	;	;	PUNCT
ajst-25612	15	18	cancer	cancer	NOUN
ajst-25612	15	19	treatment	treatment	NOUN
ajst-25612	15	20	.	.	PUNCT
ajst-25612	16	1	1	1	X
ajst-25612	16	2	.	.	X
ajst-25612	16	3	introduction	introduction	NOUN
ajst-25612	16	4	phosphatidylinositol-3	phosphatidylinositol-3	PROPN
ajst-25612	16	5	-	-	PUNCT
ajst-25612	16	6	kinase	kinase	NOUN
ajst-25612	16	7	(	(	PUNCT
ajst-25612	16	8	pi3k	pi3k	PROPN
ajst-25612	16	9	)	)	PUNCT
ajst-25612	16	10	is	be	AUX
ajst-25612	16	11	an	an	DET
ajst-25612	16	12	important	important	ADJ
ajst-25612	16	13	intracellular	intracellular	ADJ
ajst-25612	16	14	bifocal	bifocal	ADJ
ajst-25612	16	15	enzyme	enzyme	NOUN
ajst-25612	16	16	with	with	ADP
ajst-25612	16	17	both	both	DET
ajst-25612	16	18	activity	activity	NOUN
ajst-25612	16	19	of	of	ADP
ajst-25612	16	20	phosphatidylinositol	phosphatidylinositol	NOUN
ajst-25612	16	21	kinase	kinase	NOUN
ajst-25612	16	22	and	and	CCONJ
ajst-25612	16	23	the	the	DET
ajst-25612	16	24	activity	activity	NOUN
ajst-25612	16	25	of	of	ADP
ajst-25612	16	26	serine	serine	NOUN
ajst-25612	16	27	/	/	SYM
ajst-25612	16	28	threonin	threonin	NOUN
ajst-25612	16	29	(	(	PUNCT
ajst-25612	16	30	ser	ser	NOUN
ajst-25612	16	31	/	/	SYM
ajst-25612	16	32	thr	thr	PROPN
ajst-25612	16	33	)	)	PUNCT
ajst-25612	16	34	kinase	kinase	PROPN
ajst-25612	16	35	.	.	PUNCT
ajst-25612	17	1	in	in	ADP
ajst-25612	17	2	the	the	DET
ajst-25612	17	3	intracellular	intracellular	ADJ
ajst-25612	17	4	milieu	milieu	NOUN
ajst-25612	17	5	,	,	PUNCT
ajst-25612	17	6	pi3k	pi3k	PROPN
ajst-25612	17	7	participates	participate	VERB
ajst-25612	17	8	in	in	ADP
ajst-25612	17	9	a	a	DET
ajst-25612	17	10	complex	complex	ADJ
ajst-25612	17	11	signaling	signal	VERB
ajst-25612	17	12	network	network	NOUN
ajst-25612	17	13	by	by	ADP
ajst-25612	17	14	catalyzing	catalyze	VERB
ajst-25612	17	15	the	the	DET
ajst-25612	17	16	phosphorylation	phosphorylation	NOUN
ajst-25612	17	17	of	of	ADP
ajst-25612	17	18	phosphatidylinositol	phosphatidylinositol	NOUN
ajst-25612	17	19	molecules	molecule	NOUN
ajst-25612	17	20	and	and	CCONJ
ajst-25612	17	21	regulating	regulate	VERB
ajst-25612	17	22	cell	cell	NOUN
ajst-25612	17	23	survival	survival	NOUN
ajst-25612	17	24	,	,	PUNCT
ajst-25612	17	25	growth	growth	NOUN
ajst-25612	17	26	,	,	PUNCT
ajst-25612	17	27	and	and	CCONJ
ajst-25612	17	28	metabolic	metabolic	NOUN
ajst-25612	17	29	responses[1	responses[1	PROPN
ajst-25612	17	30	]	]	PUNCT
ajst-25612	17	31	.	.	PUNCT
ajst-25612	18	1	conversely	conversely	ADV
ajst-25612	18	2	,	,	PUNCT
ajst-25612	18	3	serine	serine	NOUN
ajst-25612	18	4	/	/	SYM
ajst-25612	18	5	threonine	threonine	ADJ
ajst-25612	18	6	protein	protein	NOUN
ajst-25612	18	7	kinase	kinase	PROPN
ajst-25612	18	8	(	(	PUNCT
ajst-25612	18	9	akt	akt	PROPN
ajst-25612	18	10	)	)	PUNCT
ajst-25612	18	11	is	be	AUX
ajst-25612	18	12	a	a	DET
ajst-25612	18	13	core	core	NOUN
ajst-25612	18	14	belonging	belong	VERB
ajst-25612	18	15	to	to	ADP
ajst-25612	18	16	the	the	DET
ajst-25612	18	17	serine	serine	NOUN
ajst-25612	18	18	/	/	SYM
ajst-25612	18	19	threonine	threonine	ADJ
ajst-25612	18	20	-	-	PUNCT
ajst-25612	18	21	specific	specific	ADJ
ajst-25612	18	22	family	family	NOUN
ajst-25612	18	23	of	of	ADP
ajst-25612	18	24	protein	protein	NOUN
ajst-25612	18	25	kinases	kinase	NOUN
ajst-25612	18	26	,	,	PUNCT
ajst-25612	18	27	which	which	PRON
ajst-25612	18	28	plays	play	VERB
ajst-25612	18	29	an	an	DET
ajst-25612	18	30	integral	integral	ADJ
ajst-25612	18	31	role	role	NOUN
ajst-25612	18	32	in	in	ADP
ajst-25612	18	33	numerous	numerous	ADJ
ajst-25612	18	34	fundamental	fundamental	ADJ
ajst-25612	18	35	cellular	cellular	ADJ
ajst-25612	18	36	physiological	physiological	ADJ
ajst-25612	18	37	processes	process	NOUN
ajst-25612	18	38	.	.	PUNCT
ajst-25612	19	1	akt	akt	PROPN
ajst-25612	19	2	regulates	regulate	VERB
ajst-25612	19	3	cellular	cellular	ADJ
ajst-25612	19	4	activities	activity	NOUN
ajst-25612	19	5	at	at	ADP
ajst-25612	19	6	multiple	multiple	ADJ
ajst-25612	19	7	levels	level	NOUN
ajst-25612	19	8	,	,	PUNCT
ajst-25612	19	9	including	include	VERB
ajst-25612	19	10	,	,	PUNCT
ajst-25612	19	11	but	but	CCONJ
ajst-25612	19	12	not	not	PART
ajst-25612	19	13	limited	limit	VERB
ajst-25612	19	14	to	to	ADP
ajst-25612	19	15	,	,	PUNCT
ajst-25612	19	16	critical	critical	ADJ
ajst-25612	19	17	regulation	regulation	NOUN
ajst-25612	19	18	of	of	ADP
ajst-25612	19	19	glucose	glucose	NOUN
ajst-25612	19	20	metabolism	metabolism	NOUN
ajst-25612	19	21	processes	process	NOUN
ajst-25612	19	22	,	,	PUNCT
ajst-25612	19	23	inhibitory	inhibitory	ADJ
ajst-25612	19	24	effects	effect	NOUN
ajst-25612	19	25	on	on	ADP
ajst-25612	19	26	apoptotic	apoptotic	ADJ
ajst-25612	19	27	programs	program	NOUN
ajst-25612	19	28	,	,	PUNCT
ajst-25612	19	29	effects	effect	NOUN
ajst-25612	19	30	on	on	ADP
ajst-25612	19	31	cell	cell	NOUN
ajst-25612	19	32	proliferation	proliferation	NOUN
ajst-25612	19	33	and	and	CCONJ
ajst-25612	19	34	differentiation	differentiation	NOUN
ajst-25612	19	35	processes	process	NOUN
ajst-25612	19	36	,	,	PUNCT
ajst-25612	19	37	and	and	CCONJ
ajst-25612	19	38	active	active	ADJ
ajst-25612	19	39	participation	participation	NOUN
ajst-25612	19	40	in	in	ADP
ajst-25612	19	41	transcriptional	transcriptional	ADJ
ajst-25612	19	42	regulation	regulation	NOUN
ajst-25612	19	43	and	and	CCONJ
ajst-25612	19	44	cell	cell	NOUN
ajst-25612	19	45	migration	migration	NOUN
ajst-25612	19	46	mechanisms	mechanism	NOUN
ajst-25612	19	47	.	.	PUNCT
ajst-25612	20	1	consequently	consequently	ADV
ajst-25612	20	2	,	,	PUNCT
ajst-25612	20	3	the	the	DET
ajst-25612	20	4	aberrant	aberrant	ADJ
ajst-25612	20	5	function	function	NOUN
ajst-25612	20	6	of	of	ADP
ajst-25612	20	7	akt	akt	PROPN
ajst-25612	20	8	kinase	kinase	PROPN
ajst-25612	20	9	is	be	AUX
ajst-25612	20	10	frequently	frequently	ADV
ajst-25612	20	11	associated	associate	VERB
ajst-25612	20	12	with	with	ADP
ajst-25612	20	13	the	the	DET
ajst-25612	20	14	pathogenesis	pathogenesis	NOUN
ajst-25612	20	15	of	of	ADP
ajst-25612	20	16	diverse	diverse	ADJ
ajst-25612	20	17	diseases	disease	NOUN
ajst-25612	20	18	,	,	PUNCT
ajst-25612	20	19	particularly	particularly	ADV
ajst-25612	20	20	in	in	ADP
ajst-25612	20	21	the	the	DET
ajst-25612	20	22	domains	domain	NOUN
ajst-25612	20	23	of	of	ADP
ajst-25612	20	24	tumor	tumor	NOUN
ajst-25612	20	25	biology	biology	NOUN
ajst-25612	20	26	and	and	CCONJ
ajst-25612	20	27	metabolic	metabolic	NOUN
ajst-25612	20	28	disorders	disorder	NOUN
ajst-25612	20	29	.	.	PUNCT
ajst-25612	21	1	both	both	CCONJ
ajst-25612	21	2	pi3k	pi3k	PROPN
ajst-25612	21	3	and	and	CCONJ
ajst-25612	21	4	akt	akt	PROPN
ajst-25612	21	5	belong	belong	VERB
ajst-25612	21	6	to	to	ADP
ajst-25612	21	7	the	the	DET
ajst-25612	21	8	category	category	NOUN
ajst-25612	21	9	of	of	ADP
ajst-25612	21	10	proto	proto	NOUN
ajst-25612	21	11	-	-	PUNCT
ajst-25612	21	12	oncogenes	oncogene	NOUN
ajst-25612	21	13	.	.	PUNCT
ajst-25612	22	1	immune	immune	ADJ
ajst-25612	22	2	evasion	evasion	NOUN
ajst-25612	22	3	represents	represent	VERB
ajst-25612	22	4	a	a	DET
ajst-25612	22	5	pivotal	pivotal	ADJ
ajst-25612	22	6	reason	reason	NOUN
ajst-25612	22	7	why	why	SCONJ
ajst-25612	22	8	the	the	DET
ajst-25612	22	9	immune	immune	ADJ
ajst-25612	22	10	system	system	NOUN
ajst-25612	22	11	is	be	AUX
ajst-25612	22	12	unable	unable	ADJ
ajst-25612	22	13	to	to	PART
ajst-25612	22	14	control	control	VERB
ajst-25612	22	15	the	the	DET
ajst-25612	22	16	growth	growth	NOUN
ajst-25612	22	17	of	of	ADP
ajst-25612	22	18	tumors	tumor	NOUN
ajst-25612	22	19	.	.	PUNCT
ajst-25612	23	1	this	this	DET
ajst-25612	23	2	pathway	pathway	NOUN
ajst-25612	23	3	plays	play	VERB
ajst-25612	23	4	a	a	DET
ajst-25612	23	5	pivotal	pivotal	ADJ
ajst-25612	23	6	role	role	NOUN
ajst-25612	23	7	in	in	ADP
ajst-25612	23	8	the	the	DET
ajst-25612	23	9	immune	immune	ADJ
ajst-25612	23	10	evasion	evasion	NOUN
ajst-25612	23	11	of	of	ADP
ajst-25612	23	12	cancer	cancer	NOUN
ajst-25612	23	13	cells[2	cells[2	PROPN
ajst-25612	23	14	]	]	PUNCT
ajst-25612	23	15	.	.	PUNCT
ajst-25612	24	1	2	2	X
ajst-25612	24	2	.	.	X
ajst-25612	24	3	generation	generation	NOUN
ajst-25612	24	4	of	of	ADP
ajst-25612	24	5	the	the	DET
ajst-25612	24	6	pi3k	pi3k	PROPN
ajst-25612	24	7	/	/	SYM
ajst-25612	24	8	akt	akt	PROPN
ajst-25612	24	9	pathway	pathway	NOUN
ajst-25612	24	10	g	g	PROPN
ajst-25612	24	11	protein	protein	NOUN
ajst-25612	24	12	-	-	PUNCT
ajst-25612	24	13	coupled	couple	VERB
ajst-25612	24	14	receptors	receptor	NOUN
ajst-25612	24	15	play	play	VERB
ajst-25612	24	16	a	a	DET
ajst-25612	24	17	pivotal	pivotal	ADJ
ajst-25612	24	18	role	role	NOUN
ajst-25612	24	19	in	in	ADP
ajst-25612	24	20	the	the	DET
ajst-25612	24	21	regulation	regulation	NOUN
ajst-25612	24	22	of	of	ADP
ajst-25612	24	23	the	the	DET
ajst-25612	24	24	pi3k	pi3k	PROPN
ajst-25612	24	25	/	/	SYM
ajst-25612	24	26	akt	akt	PROPN
ajst-25612	24	27	signaling	signal	VERB
ajst-25612	24	28	pathway	pathway	NOUN
ajst-25612	24	29	.	.	PUNCT
ajst-25612	25	1	upon	upon	SCONJ
ajst-25612	25	2	interaction	interaction	NOUN
ajst-25612	25	3	with	with	ADP
ajst-25612	25	4	a	a	DET
ajst-25612	25	5	specific	specific	ADJ
ajst-25612	25	6	exogenous	exogenous	ADJ
ajst-25612	25	7	signaling	signal	VERB
ajst-25612	25	8	molecule	molecule	NOUN
ajst-25612	25	9	,	,	PUNCT
ajst-25612	25	10	a	a	DET
ajst-25612	25	11	g	g	NOUN
ajst-25612	25	12	protein	protein	NOUN
ajst-25612	25	13	-	-	PUNCT
ajst-25612	25	14	coupled	couple	VERB
ajst-25612	25	15	receptor	receptor	NOUN
ajst-25612	25	16	undergoes	undergo	VERB
ajst-25612	25	17	a	a	DET
ajst-25612	25	18	conformational	conformational	ADJ
ajst-25612	25	19	change	change	NOUN
ajst-25612	25	20	that	that	PRON
ajst-25612	25	21	effectively	effectively	ADV
ajst-25612	25	22	activates	activate	VERB
ajst-25612	25	23	the	the	DET
ajst-25612	25	24	g	g	NOUN
ajst-25612	25	25	protein	protein	NOUN
ajst-25612	25	26	to	to	PART
ajst-25612	25	27	which	which	PRON
ajst-25612	25	28	it	it	PRON
ajst-25612	25	29	is	be	AUX
ajst-25612	25	30	coupled	couple	VERB
ajst-25612	25	31	.	.	PUNCT
ajst-25612	26	1	the	the	DET
ajst-25612	26	2	activation	activation	NOUN
ajst-25612	26	3	of	of	ADP
ajst-25612	26	4	pi3k	pi3k	PROPN
ajst-25612	26	5	is	be	AUX
ajst-25612	26	6	mediated	mediate	VERB
ajst-25612	26	7	by	by	ADP
ajst-25612	26	8	activated	activate	VERB
ajst-25612	26	9	g	g	PROPN
ajst-25612	26	10	proteins	protein	NOUN
ajst-25612	26	11	,	,	PUNCT
ajst-25612	26	12	which	which	PRON
ajst-25612	26	13	stimulate	stimulate	VERB
ajst-25612	26	14	pi3k	pi3k	NOUN
ajst-25612	26	15	and	and	CCONJ
ajst-25612	26	16	activate	activate	VERB
ajst-25612	26	17	its	its	PRON
ajst-25612	26	18	catalytic	catalytic	ADJ
ajst-25612	26	19	activity	activity	NOUN
ajst-25612	26	20	,	,	PUNCT
ajst-25612	26	21	thereby	thereby	ADV
ajst-25612	26	22	catalyzing	catalyze	VERB
ajst-25612	26	23	the	the	DET
ajst-25612	26	24	conversion	conversion	NOUN
ajst-25612	26	25	of	of	ADP
ajst-25612	26	26	phosphatidylinositol	phosphatidylinositol	NOUN
ajst-25612	26	27	diphosphate	diphosphate	NOUN
ajst-25612	26	28	(	(	PUNCT
ajst-25612	26	29	pip2	pip2	PROPN
ajst-25612	26	30	)	)	PUNCT
ajst-25612	26	31	to	to	PART
ajst-25612	26	32	phosphatidylinositol	phosphatidylinositol	NOUN
ajst-25612	26	33	trisphosphate	trisphosphate	NOUN
ajst-25612	26	34	(	(	PUNCT
ajst-25612	26	35	pip3	pip3	PROPN
ajst-25612	26	36	)	)	PUNCT
ajst-25612	26	37	on	on	ADP
ajst-25612	26	38	the	the	DET
ajst-25612	26	39	cell	cell	NOUN
ajst-25612	26	40	membrane	membrane	NOUN
ajst-25612	26	41	.	.	PUNCT
ajst-25612	27	1	at	at	ADP
ajst-25612	27	2	the	the	DET
ajst-25612	27	3	same	same	ADJ
ajst-25612	27	4	time	time	NOUN
ajst-25612	27	5	,	,	PUNCT
ajst-25612	27	6	the	the	DET
ajst-25612	27	7	presence	presence	NOUN
ajst-25612	27	8	of	of	ADP
ajst-25612	27	9	a	a	DET
ajst-25612	27	10	phosphatase	phosphatase	NOUN
ajst-25612	27	11	called	call	VERB
ajst-25612	27	12	pten	pten	NOUN
ajst-25612	27	13	,	,	PUNCT
ajst-25612	27	14	a	a	DET
ajst-25612	27	15	tumor	tumor	NOUN
ajst-25612	27	16	suppressor	suppressor	NOUN
ajst-25612	27	17	gene	gene	NOUN
ajst-25612	27	18	,	,	PUNCT
ajst-25612	27	19	can	can	AUX
ajst-25612	27	20	reverse	reverse	VERB
ajst-25612	27	21	catalyze	catalyze	NOUN
ajst-25612	27	22	this	this	DET
ajst-25612	27	23	process	process	NOUN
ajst-25612	27	24	,	,	PUNCT
ajst-25612	27	25	inhibiting	inhibit	VERB
ajst-25612	27	26	the	the	DET
ajst-25612	27	27	downstream	downstream	ADJ
ajst-25612	27	28	signaling	signaling	NOUN
ajst-25612	27	29	of	of	ADP
ajst-25612	27	30	the	the	DET
ajst-25612	27	31	pi3k	pi3k	PROPN
ajst-25612	27	32	pathway	pathway	NOUN
ajst-25612	27	33	through	through	ADP
ajst-25612	27	34	dephosphorylation	dephosphorylation	NOUN
ajst-25612	27	35	of	of	ADP
ajst-25612	27	36	pip3	pip3	PROPN
ajst-25612	27	37	.	.	PUNCT
ajst-25612	28	1	as	as	ADP
ajst-25612	28	2	a	a	DET
ajst-25612	28	3	key	key	ADJ
ajst-25612	28	4	second	second	ADJ
ajst-25612	28	5	messenger	messenger	NOUN
ajst-25612	28	6	molecule	molecule	NOUN
ajst-25612	28	7	,	,	PUNCT
ajst-25612	28	8	pip3	pip3	PROPN
ajst-25612	28	9	can	can	AUX
ajst-25612	28	10	recruit	recruit	VERB
ajst-25612	28	11	and	and	CCONJ
ajst-25612	28	12	anchor	anchor	VERB
ajst-25612	28	13	akt	akt	PROPN
ajst-25612	28	14	and	and	CCONJ
ajst-25612	28	15	its	its	PRON
ajst-25612	28	16	upstream	upstream	ADJ
ajst-25612	28	17	activator	activator	NOUN
ajst-25612	28	18	pdk1	pdk1	NOUN
ajst-25612	28	19	on	on	ADP
ajst-25612	28	20	the	the	DET
ajst-25612	28	21	cell	cell	NOUN
ajst-25612	28	22	membrane	membrane	NOUN
ajst-25612	28	23	after	after	ADP
ajst-25612	28	24	its	its	PRON
ajst-25612	28	25	production[3	production[3	PROPN
ajst-25612	28	26	]	]	PUNCT
ajst-25612	28	27	.	.	PUNCT
ajst-25612	29	1	this	this	DET
ajst-25612	29	2	process	process	NOUN
ajst-25612	29	3	directs	direct	VERB
ajst-25612	29	4	the	the	DET
ajst-25612	29	5	transfer	transfer	NOUN
ajst-25612	29	6	of	of	ADP
ajst-25612	29	7	akt	akt	PROPN
ajst-25612	29	8	to	to	ADP
ajst-25612	29	9	the	the	DET
ajst-25612	29	10	plasma	plasma	NOUN
ajst-25612	29	11	membrane	membrane	NOUN
ajst-25612	29	12	and	and	CCONJ
ajst-25612	29	13	initiates	initiate	VERB
ajst-25612	29	14	its	its	PRON
ajst-25612	29	15	partial	partial	ADJ
ajst-25612	29	16	activation	activation	NOUN
ajst-25612	29	17	state	state	NOUN
ajst-25612	29	18	.	.	PUNCT
ajst-25612	30	1	once	once	ADV
ajst-25612	30	2	fully	fully	ADV
ajst-25612	30	3	171	171	NUM
ajst-25612	30	4	activated	activate	VERB
ajst-25612	30	5	,	,	PUNCT
ajst-25612	30	6	akt	akt	PROPN
ajst-25612	30	7	efficiently	efficiently	ADV
ajst-25612	30	8	transmits	transmit	VERB
ajst-25612	30	9	survival	survival	NOUN
ajst-25612	30	10	and	and	CCONJ
ajst-25612	30	11	proliferation	proliferation	NOUN
ajst-25612	30	12	signals	signal	NOUN
ajst-25612	30	13	to	to	ADP
ajst-25612	30	14	various	various	ADJ
ajst-25612	30	15	intracellular	intracellular	ADJ
ajst-25612	30	16	pathways	pathway	NOUN
ajst-25612	30	17	by	by	ADP
ajst-25612	30	18	phosphorylating	phosphorylate	VERB
ajst-25612	30	19	a	a	DET
ajst-25612	30	20	series	series	NOUN
ajst-25612	30	21	of	of	ADP
ajst-25612	30	22	substrate	substrate	NOUN
ajst-25612	30	23	proteins	protein	NOUN
ajst-25612	30	24	.	.	PUNCT
ajst-25612	31	1	consequently	consequently	ADV
ajst-25612	31	2	,	,	PUNCT
ajst-25612	31	3	the	the	DET
ajst-25612	31	4	activation	activation	NOUN
ajst-25612	31	5	of	of	ADP
ajst-25612	31	6	akt	akt	PROPN
ajst-25612	31	7	strongly	strongly	ADV
ajst-25612	31	8	promotes	promote	VERB
ajst-25612	31	9	cell	cell	NOUN
ajst-25612	31	10	survival	survival	NOUN
ajst-25612	31	11	,	,	PUNCT
ajst-25612	31	12	proliferation	proliferation	NOUN
ajst-25612	31	13	rate	rate	NOUN
ajst-25612	31	14	,	,	PUNCT
ajst-25612	31	15	and	and	CCONJ
ajst-25612	31	16	growth	growth	NOUN
ajst-25612	31	17	.	.	PUNCT
ajst-25612	32	1	it	it	PRON
ajst-25612	32	2	is	be	AUX
ajst-25612	32	3	also	also	ADV
ajst-25612	32	4	deeply	deeply	ADV
ajst-25612	32	5	engaged	engage	VERB
ajst-25612	32	6	in	in	ADP
ajst-25612	32	7	diverse	diverse	ADJ
ajst-25612	32	8	cellular	cellular	ADJ
ajst-25612	32	9	physiological	physiological	ADJ
ajst-25612	32	10	activities	activity	NOUN
ajst-25612	32	11	,	,	PUNCT
ajst-25612	32	12	inclusive	inclusive	ADJ
ajst-25612	32	13	of	of	ADP
ajst-25612	32	14	the	the	DET
ajst-25612	32	15	regulation	regulation	NOUN
ajst-25612	32	16	of	of	ADP
ajst-25612	32	17	glucose	glucose	NOUN
ajst-25612	32	18	metabolism	metabolism	NOUN
ajst-25612	32	19	and	and	CCONJ
ajst-25612	32	20	cell	cell	NOUN
ajst-25612	32	21	cycle	cycle	NOUN
ajst-25612	32	22	progression	progression	NOUN
ajst-25612	32	23	.	.	PUNCT
ajst-25612	33	1	in	in	ADP
ajst-25612	33	2	conclusion	conclusion	NOUN
ajst-25612	33	3	,	,	PUNCT
ajst-25612	33	4	g	g	NOUN
ajst-25612	33	5	protein	protein	NOUN
ajst-25612	33	6	-	-	PUNCT
ajst-25612	33	7	coupled	couple	VERB
ajst-25612	33	8	receptors	receptor	NOUN
ajst-25612	33	9	exert	exert	VERB
ajst-25612	33	10	a	a	DET
ajst-25612	33	11	profound	profound	ADJ
ajst-25612	33	12	influence	influence	NOUN
ajst-25612	33	13	on	on	ADP
ajst-25612	33	14	numerous	numerous	ADJ
ajst-25612	33	15	physiological	physiological	ADJ
ajst-25612	33	16	and	and	CCONJ
ajst-25612	33	17	biochemical	biochemical	ADJ
ajst-25612	33	18	responses	response	NOUN
ajst-25612	33	19	of	of	ADP
ajst-25612	33	20	cells	cell	NOUN
ajst-25612	33	21	by	by	ADP
ajst-25612	33	22	initiating	initiate	VERB
ajst-25612	33	23	the	the	DET
ajst-25612	33	24	pathway	pathway	NOUN
ajst-25612	33	25	involving	involve	VERB
ajst-25612	33	26	pi3k	pi3k	PROPN
ajst-25612	33	27	/	/	SYM
ajst-25612	33	28	akt	akt	PROPN
ajst-25612	33	29	signaling	signal	VERB
ajst-25612	33	30	.	.	PUNCT
ajst-25612	34	1	this	this	DET
ajst-25612	34	2	pathway	pathway	NOUN
ajst-25612	34	3	holds	hold	VERB
ajst-25612	34	4	a	a	DET
ajst-25612	34	5	crucial	crucial	ADJ
ajst-25612	34	6	position	position	NOUN
ajst-25612	34	7	in	in	ADP
ajst-25612	34	8	maintaining	maintain	VERB
ajst-25612	34	9	normal	normal	ADJ
ajst-25612	34	10	physiological	physiological	ADJ
ajst-25612	34	11	homeostasis	homeostasis	NOUN
ajst-25612	34	12	and	and	CCONJ
ajst-25612	34	13	in	in	ADP
ajst-25612	34	14	regulating	regulate	VERB
ajst-25612	34	15	various	various	ADJ
ajst-25612	34	16	pathological	pathological	ADJ
ajst-25612	34	17	conditions[4	conditions[4	PROPN
ajst-25612	34	18	]	]	NOUN
ajst-25612	34	19	.	.	PUNCT
ajst-25612	35	1	3	3	X
ajst-25612	35	2	.	.	X
ajst-25612	35	3	pi3k	pi3k	NOUN
ajst-25612	35	4	/	/	SYM
ajst-25612	35	5	akt	akt	PROPN
ajst-25612	35	6	pathway	pathway	NOUN
ajst-25612	35	7	and	and	CCONJ
ajst-25612	35	8	apoptosis	apoptosis	VERB
ajst-25612	35	9	the	the	DET
ajst-25612	35	10	activation	activation	NOUN
ajst-25612	35	11	of	of	ADP
ajst-25612	35	12	akt	akt	PROPN
ajst-25612	35	13	kinase	kinase	PROPN
ajst-25612	35	14	plays	play	VERB
ajst-25612	35	15	a	a	DET
ajst-25612	35	16	pivotal	pivotal	ADJ
ajst-25612	35	17	role	role	NOUN
ajst-25612	35	18	in	in	ADP
ajst-25612	35	19	cell	cell	NOUN
ajst-25612	35	20	biology	biology	NOUN
ajst-25612	35	21	,	,	PUNCT
ajst-25612	35	22	enhancing	enhance	VERB
ajst-25612	35	23	the	the	DET
ajst-25612	35	24	viability	viability	NOUN
ajst-25612	35	25	of	of	ADP
ajst-25612	35	26	tumor	tumor	NOUN
ajst-25612	35	27	cells	cell	NOUN
ajst-25612	35	28	by	by	ADP
ajst-25612	35	29	inhibiting	inhibit	VERB
ajst-25612	35	30	the	the	DET
ajst-25612	35	31	process	process	NOUN
ajst-25612	35	32	of	of	ADP
ajst-25612	35	33	programmed	program	VERB
ajst-25612	35	34	cell	cell	NOUN
ajst-25612	35	35	death	death	NOUN
ajst-25612	35	36	,	,	PUNCT
ajst-25612	35	37	or	or	CCONJ
ajst-25612	35	38	apoptosis	apoptosis	NOUN
ajst-25612	35	39	.	.	PUNCT
ajst-25612	36	1	this	this	DET
ajst-25612	36	2	process	process	NOUN
ajst-25612	36	3	essentially	essentially	ADV
ajst-25612	36	4	enables	enable	VERB
ajst-25612	36	5	cancer	cancer	NOUN
ajst-25612	36	6	cells	cell	NOUN
ajst-25612	36	7	to	to	PART
ajst-25612	36	8	circumvent	circumvent	VERB
ajst-25612	36	9	the	the	DET
ajst-25612	36	10	natural	natural	ADJ
ajst-25612	36	11	clearance	clearance	NOUN
ajst-25612	36	12	mechanism	mechanism	NOUN
ajst-25612	36	13	of	of	ADP
ajst-25612	36	14	the	the	DET
ajst-25612	36	15	body	body	NOUN
ajst-25612	36	16	's	's	PART
ajst-25612	36	17	immune	immune	ADJ
ajst-25612	36	18	system	system	NOUN
ajst-25612	36	19	,	,	PUNCT
ajst-25612	36	20	which	which	PRON
ajst-25612	36	21	is	be	AUX
ajst-25612	36	22	responsible	responsible	ADJ
ajst-25612	36	23	for	for	ADP
ajst-25612	36	24	destroying	destroy	VERB
ajst-25612	36	25	abnormal	abnormal	ADJ
ajst-25612	36	26	cells	cell	NOUN
ajst-25612	36	27	through	through	ADP
ajst-25612	36	28	its	its	PRON
ajst-25612	36	29	own	own	ADJ
ajst-25612	36	30	apoptotic	apoptotic	ADJ
ajst-25612	36	31	pathway	pathway	NOUN
ajst-25612	36	32	.	.	PUNCT
ajst-25612	37	1	in	in	ADP
ajst-25612	37	2	recent	recent	ADJ
ajst-25612	37	3	years	year	NOUN
ajst-25612	37	4	,	,	PUNCT
ajst-25612	37	5	it	it	PRON
ajst-25612	37	6	has	have	AUX
ajst-25612	37	7	been	be	AUX
ajst-25612	37	8	demonstrated	demonstrate	VERB
ajst-25612	37	9	that	that	SCONJ
ajst-25612	37	10	this	this	DET
ajst-25612	37	11	signaling	signal	VERB
ajst-25612	37	12	pathway	pathway	NOUN
ajst-25612	37	13	is	be	AUX
ajst-25612	37	14	frequently	frequently	ADV
ajst-25612	37	15	aberrantly	aberrantly	ADV
ajst-25612	37	16	activated	activate	VERB
ajst-25612	37	17	in	in	ADP
ajst-25612	37	18	a	a	DET
ajst-25612	37	19	multitude	multitude	NOUN
ajst-25612	37	20	of	of	ADP
ajst-25612	37	21	cancer	cancer	NOUN
ajst-25612	37	22	types	type	NOUN
ajst-25612	37	23	.	.	PUNCT
ajst-25612	38	1	this	this	DET
ajst-25612	38	2	abnormality	abnormality	NOUN
ajst-25612	38	3	is	be	AUX
ajst-25612	38	4	typically	typically	ADV
ajst-25612	38	5	attributable	attributable	ADJ
ajst-25612	38	6	to	to	ADP
ajst-25612	38	7	a	a	DET
ajst-25612	38	8	multitude	multitude	NOUN
ajst-25612	38	9	of	of	ADP
ajst-25612	38	10	factors	factor	NOUN
ajst-25612	38	11	,	,	PUNCT
ajst-25612	38	12	including	include	VERB
ajst-25612	38	13	,	,	PUNCT
ajst-25612	38	14	but	but	CCONJ
ajst-25612	38	15	not	not	PART
ajst-25612	38	16	limited	limit	VERB
ajst-25612	38	17	to	to	ADP
ajst-25612	38	18	,	,	PUNCT
ajst-25612	38	19	the	the	DET
ajst-25612	38	20	amplification	amplification	NOUN
ajst-25612	38	21	of	of	ADP
ajst-25612	38	22	the	the	DET
ajst-25612	38	23	pi3k	pi3k	PROPN
ajst-25612	38	24	catalytic	catalytic	ADJ
ajst-25612	38	25	subunit	subunit	NOUN
ajst-25612	38	26	gene	gene	NOUN
ajst-25612	38	27	,	,	PUNCT
ajst-25612	38	28	which	which	PRON
ajst-25612	38	29	results	result	VERB
ajst-25612	38	30	in	in	ADP
ajst-25612	38	31	elevated	elevated	ADJ
ajst-25612	38	32	pi3k	pi3k	NOUN
ajst-25612	38	33	activity	activity	NOUN
ajst-25612	38	34	,	,	PUNCT
ajst-25612	38	35	or	or	CCONJ
ajst-25612	38	36	the	the	DET
ajst-25612	38	37	over	over	NOUN
ajst-25612	38	38	-	-	PUNCT
ajst-25612	38	39	activation	activation	NOUN
ajst-25612	38	40	of	of	ADP
ajst-25612	38	41	akt	akt	PROPN
ajst-25612	38	42	itself	itself	PRON
ajst-25612	38	43	due	due	ADP
ajst-25612	38	44	to	to	ADP
ajst-25612	38	45	a	a	DET
ajst-25612	38	46	range	range	NOUN
ajst-25612	38	47	of	of	ADP
ajst-25612	38	48	contributing	contribute	VERB
ajst-25612	38	49	factors	factor	NOUN
ajst-25612	38	50	.	.	PUNCT
ajst-25612	39	1	additionally	additionally	ADV
ajst-25612	39	2	,	,	PUNCT
ajst-25612	39	3	the	the	DET
ajst-25612	39	4	mutation	mutation	NOUN
ajst-25612	39	5	or	or	CCONJ
ajst-25612	39	6	loss	loss	NOUN
ajst-25612	39	7	of	of	ADP
ajst-25612	39	8	function	function	NOUN
ajst-25612	39	9	of	of	ADP
ajst-25612	39	10	negative	negative	ADJ
ajst-25612	39	11	regulators	regulator	NOUN
ajst-25612	39	12	of	of	ADP
ajst-25612	39	13	the	the	DET
ajst-25612	39	14	pathway	pathway	NOUN
ajst-25612	39	15	,	,	PUNCT
ajst-25612	39	16	such	such	ADJ
ajst-25612	39	17	as	as	ADP
ajst-25612	39	18	pten	pten	NOUN
ajst-25612	39	19	,	,	PUNCT
ajst-25612	39	20	represents	represent	VERB
ajst-25612	39	21	another	another	DET
ajst-25612	39	22	significant	significant	ADJ
ajst-25612	39	23	contributing	contribute	VERB
ajst-25612	39	24	factor	factor	NOUN
ajst-25612	39	25	to	to	ADP
ajst-25612	39	26	the	the	DET
ajst-25612	39	27	persistent	persistent	ADJ
ajst-25612	39	28	activation	activation	NOUN
ajst-25612	39	29	of	of	ADP
ajst-25612	39	30	akt	akt	PROPN
ajst-25612	39	31	.	.	PUNCT
ajst-25612	40	1	recent	recent	ADJ
ajst-25612	40	2	studies	study	NOUN
ajst-25612	40	3	have	have	AUX
ajst-25612	40	4	demonstrated	demonstrate	VERB
ajst-25612	40	5	the	the	DET
ajst-25612	40	6	efficacy	efficacy	NOUN
ajst-25612	40	7	of	of	ADP
ajst-25612	40	8	the	the	DET
ajst-25612	40	9	pi3k	pi3k	PROPN
ajst-25612	40	10	/	/	SYM
ajst-25612	40	11	akt	akt	PROPN
ajst-25612	40	12	pathway	pathway	NOUN
ajst-25612	40	13	in	in	ADP
ajst-25612	40	14	inhibiting	inhibit	VERB
ajst-25612	40	15	apoptosis	apoptosis	NOUN
ajst-25612	40	16	and	and	CCONJ
ajst-25612	40	17	promoting	promote	VERB
ajst-25612	40	18	cancer	cancer	NOUN
ajst-25612	40	19	cell	cell	NOUN
ajst-25612	40	20	survival	survival	NOUN
ajst-25612	40	21	through	through	ADP
ajst-25612	40	22	a	a	DET
ajst-25612	40	23	multitude	multitude	NOUN
ajst-25612	40	24	of	of	ADP
ajst-25612	40	25	mechanisms	mechanism	NOUN
ajst-25612	40	26	.	.	PUNCT
ajst-25612	41	1	the	the	DET
ajst-25612	41	2	aforementioned	aforementione	VERB
ajst-25612	41	3	mechanisms	mechanism	NOUN
ajst-25612	41	4	include	include	VERB
ajst-25612	41	5	the	the	DET
ajst-25612	41	6	following	following	NOUN
ajst-25612	41	7	:	:	PUNCT
ajst-25612	41	8	the	the	DET
ajst-25612	41	9	pathway	pathway	NOUN
ajst-25612	41	10	directly	directly	ADV
ajst-25612	41	11	affects	affect	VERB
ajst-25612	41	12	the	the	DET
ajst-25612	41	13	phosphorylation	phosphorylation	NOUN
ajst-25612	41	14	of	of	ADP
ajst-25612	41	15	apoptosisassociated	apoptosisassociate	VERB
ajst-25612	41	16	proteins	protein	NOUN
ajst-25612	41	17	and	and	CCONJ
ajst-25612	41	18	alters	alter	VERB
ajst-25612	41	19	their	their	PRON
ajst-25612	41	20	activity	activity	NOUN
ajst-25612	41	21	status	status	NOUN
ajst-25612	41	22	to	to	PART
ajst-25612	41	23	block	block	VERB
ajst-25612	41	24	apoptosis	apoptosis	NOUN
ajst-25612	41	25	.	.	PUNCT
ajst-25612	42	1	it	it	PRON
ajst-25612	42	2	also	also	ADV
ajst-25612	42	3	plays	play	VERB
ajst-25612	42	4	a	a	DET
ajst-25612	42	5	central	central	ADJ
ajst-25612	42	6	role	role	NOUN
ajst-25612	42	7	in	in	ADP
ajst-25612	42	8	regulating	regulate	VERB
ajst-25612	42	9	cell	cell	NOUN
ajst-25612	42	10	survival	survival	NOUN
ajst-25612	42	11	and	and	CCONJ
ajst-25612	42	12	death	death	NOUN
ajst-25612	42	13	decisions	decision	NOUN
ajst-25612	42	14	by	by	ADP
ajst-25612	42	15	directly	directly	ADV
ajst-25612	42	16	affecting	affect	VERB
ajst-25612	42	17	or	or	CCONJ
ajst-25612	42	18	indirectly	indirectly	ADV
ajst-25612	42	19	regulating	regulate	VERB
ajst-25612	42	20	a	a	DET
ajst-25612	42	21	series	series	NOUN
ajst-25612	42	22	of	of	ADP
ajst-25612	42	23	key	key	ADJ
ajst-25612	42	24	transcription	transcription	NOUN
ajst-25612	42	25	factors	factor	NOUN
ajst-25612	42	26	.	.	PUNCT
ajst-25612	43	1	the	the	DET
ajst-25612	43	2	pathway	pathway	NOUN
ajst-25612	43	3	also	also	ADV
ajst-25612	43	4	regulates	regulate	VERB
ajst-25612	43	5	cell	cell	NOUN
ajst-25612	43	6	cycle	cycle	NOUN
ajst-25612	43	7	progression	progression	NOUN
ajst-25612	43	8	,	,	PUNCT
ajst-25612	43	9	ensuring	ensure	VERB
ajst-25612	43	10	that	that	SCONJ
ajst-25612	43	11	cancer	cancer	NOUN
ajst-25612	43	12	cells	cell	NOUN
ajst-25612	43	13	are	be	AUX
ajst-25612	43	14	not	not	PART
ajst-25612	43	15	subject	subject	ADJ
ajst-25612	43	16	to	to	ADP
ajst-25612	43	17	normal	normal	ADJ
ajst-25612	43	18	cell	cell	NOUN
ajst-25612	43	19	cycle	cycle	NOUN
ajst-25612	43	20	checkpoints	checkpoint	NOUN
ajst-25612	43	21	and	and	CCONJ
ajst-25612	43	22	thus	thus	ADV
ajst-25612	43	23	maintaining	maintain	VERB
ajst-25612	43	24	rapid	rapid	ADJ
ajst-25612	43	25	and	and	CCONJ
ajst-25612	43	26	uncontrolled	uncontrolled	ADJ
ajst-25612	43	27	proliferation	proliferation	NOUN
ajst-25612	43	28	.	.	PUNCT
ajst-25612	44	1	additionally	additionally	ADV
ajst-25612	44	2	,	,	PUNCT
ajst-25612	44	3	it	it	PRON
ajst-25612	44	4	maintains	maintain	VERB
ajst-25612	44	5	mitochondrial	mitochondrial	ADJ
ajst-25612	44	6	homeostasis	homeostasis	NOUN
ajst-25612	44	7	,	,	PUNCT
ajst-25612	44	8	preventing	prevent	VERB
ajst-25612	44	9	mitochondria	mitochondria	NOUN
ajst-25612	44	10	from	from	ADP
ajst-25612	44	11	releasing	release	VERB
ajst-25612	44	12	intrinsic	intrinsic	ADJ
ajst-25612	44	13	factors	factor	NOUN
ajst-25612	44	14	that	that	PRON
ajst-25612	44	15	trigger	trigger	NOUN
ajst-25612	44	16	apoptosis	apoptosis	NOUN
ajst-25612	44	17	,	,	PUNCT
ajst-25612	44	18	thereby	thereby	ADV
ajst-25612	44	19	protecting	protect	VERB
ajst-25612	44	20	cancer	cancer	NOUN
ajst-25612	44	21	cells	cell	NOUN
ajst-25612	44	22	from	from	ADP
ajst-25612	44	23	the	the	DET
ajst-25612	44	24	initiation	initiation	NOUN
ajst-25612	44	25	and	and	CCONJ
ajst-25612	44	26	execution	execution	NOUN
ajst-25612	44	27	of	of	ADP
ajst-25612	44	28	the	the	DET
ajst-25612	44	29	internal	internal	ADJ
ajst-25612	44	30	apoptotic	apoptotic	ADJ
ajst-25612	44	31	pathway	pathway	NOUN
ajst-25612	44	32	.	.	PUNCT
ajst-25612	45	1	abnormal	abnormal	ADJ
ajst-25612	45	2	activation	activation	NOUN
ajst-25612	45	3	of	of	ADP
ajst-25612	45	4	this	this	DET
ajst-25612	45	5	pathway	pathway	NOUN
ajst-25612	45	6	represents	represent	VERB
ajst-25612	45	7	a	a	DET
ajst-25612	45	8	central	central	ADJ
ajst-25612	45	9	strategy	strategy	NOUN
ajst-25612	45	10	employed	employ	VERB
ajst-25612	45	11	by	by	ADP
ajst-25612	45	12	tumor	tumor	NOUN
ajst-25612	45	13	cells	cell	NOUN
ajst-25612	45	14	to	to	PART
ajst-25612	45	15	evade	evade	VERB
ajst-25612	45	16	apoptosis	apoptosis	NOUN
ajst-25612	45	17	,	,	PUNCT
ajst-25612	45	18	acquire	acquire	VERB
ajst-25612	45	19	drug	drug	NOUN
ajst-25612	45	20	resistance	resistance	NOUN
ajst-25612	45	21	,	,	PUNCT
ajst-25612	45	22	and	and	CCONJ
ajst-25612	45	23	promote	promote	VERB
ajst-25612	45	24	tumor	tumor	NOUN
ajst-25612	45	25	progression	progression	NOUN
ajst-25612	45	26	.	.	PUNCT
ajst-25612	46	1	this	this	PRON
ajst-25612	46	2	provides	provide	VERB
ajst-25612	46	3	a	a	DET
ajst-25612	46	4	theoretical	theoretical	ADJ
ajst-25612	46	5	rationale	rationale	NOUN
ajst-25612	46	6	for	for	ADP
ajst-25612	46	7	the	the	DET
ajst-25612	46	8	development	development	NOUN
ajst-25612	46	9	of	of	ADP
ajst-25612	46	10	anticancer	anticancer	NOUN
ajst-25612	46	11	drugs	drug	NOUN
ajst-25612	46	12	targeting	target	VERB
ajst-25612	46	13	this	this	DET
ajst-25612	46	14	pathway[5	pathway[5	NOUN
ajst-25612	46	15	]	]	X
ajst-25612	46	16	.	.	PUNCT
ajst-25612	47	1	programmed	program	VERB
ajst-25612	47	2	cell	cell	NOUN
ajst-25612	47	3	death	death	NOUN
ajst-25612	47	4	ligand	ligand	NOUN
ajst-25612	47	5	1	1	NUM
ajst-25612	47	6	(	(	PUNCT
ajst-25612	47	7	pd	pd	NOUN
ajst-25612	47	8	-	-	PUNCT
ajst-25612	47	9	l1	l1	PROPN
ajst-25612	47	10	)	)	PUNCT
ajst-25612	47	11	,	,	PUNCT
ajst-25612	47	12	an	an	DET
ajst-25612	47	13	immune	immune	ADJ
ajst-25612	47	14	checkpoint	checkpoint	NOUN
ajst-25612	47	15	molecule	molecule	NOUN
ajst-25612	47	16	,	,	PUNCT
ajst-25612	47	17	is	be	AUX
ajst-25612	47	18	closely	closely	ADV
ajst-25612	47	19	associated	associate	VERB
ajst-25612	47	20	with	with	ADP
ajst-25612	47	21	bidirectional	bidirectional	ADJ
ajst-25612	47	22	regulation	regulation	NOUN
ajst-25612	47	23	during	during	ADP
ajst-25612	47	24	epithelial	epithelial	ADJ
ajst-25612	47	25	-	-	PUNCT
ajst-25612	47	26	mesenchymal	mesenchymal	NOUN
ajst-25612	47	27	transition	transition	NOUN
ajst-25612	47	28	(	(	PUNCT
ajst-25612	47	29	emt	emt	PROPN
ajst-25612	47	30	)	)	PUNCT
ajst-25612	47	31	.	.	PUNCT
ajst-25612	48	1	in	in	ADP
ajst-25612	48	2	a	a	DET
ajst-25612	48	3	variety	variety	NOUN
ajst-25612	48	4	of	of	ADP
ajst-25612	48	5	tumor	tumor	NOUN
ajst-25612	48	6	types	type	NOUN
ajst-25612	48	7	,	,	PUNCT
ajst-25612	48	8	including	include	VERB
ajst-25612	48	9	lung	lung	NOUN
ajst-25612	48	10	cancer	cancer	NOUN
ajst-25612	48	11	and	and	CCONJ
ajst-25612	48	12	breast	breast	NOUN
ajst-25612	48	13	cancer	cancer	NOUN
ajst-25612	48	14	,	,	PUNCT
ajst-25612	48	15	there	there	PRON
ajst-25612	48	16	is	be	VERB
ajst-25612	48	17	a	a	DET
ajst-25612	48	18	positive	positive	ADJ
ajst-25612	48	19	or	or	CCONJ
ajst-25612	48	20	negative	negative	ADJ
ajst-25612	48	21	relationship	relationship	NOUN
ajst-25612	48	22	between	between	ADP
ajst-25612	48	23	pd	pd	PROPN
ajst-25612	48	24	-	-	PROPN
ajst-25612	48	25	l1	l1	PROPN
ajst-25612	48	26	expression	expression	NOUN
ajst-25612	48	27	and	and	CCONJ
ajst-25612	48	28	the	the	DET
ajst-25612	48	29	levels	level	NOUN
ajst-25612	48	30	of	of	ADP
ajst-25612	48	31	emt	emt	PROPN
ajst-25612	48	32	markers	marker	NOUN
ajst-25612	48	33	,	,	PUNCT
ajst-25612	48	34	indicating	indicate	VERB
ajst-25612	48	35	that	that	SCONJ
ajst-25612	48	36	pd	pd	PROPN
ajst-25612	48	37	-	-	PROPN
ajst-25612	48	38	l1	l1	PROPN
ajst-25612	48	39	plays	play	VERB
ajst-25612	48	40	a	a	DET
ajst-25612	48	41	pivotal	pivotal	ADJ
ajst-25612	48	42	role	role	NOUN
ajst-25612	48	43	in	in	ADP
ajst-25612	48	44	the	the	DET
ajst-25612	48	45	dynamics	dynamic	NOUN
ajst-25612	48	46	of	of	ADP
ajst-25612	48	47	emt	emt	PROPN
ajst-25612	48	48	.	.	PUNCT
ajst-25612	49	1	the	the	DET
ajst-25612	49	2	mechanism	mechanism	NOUN
ajst-25612	49	3	of	of	ADP
ajst-25612	49	4	upregulation	upregulation	NOUN
ajst-25612	49	5	of	of	ADP
ajst-25612	49	6	pd	pd	PROPN
ajst-25612	49	7	-	-	PROPN
ajst-25612	49	8	l1	l1	PROPN
ajst-25612	49	9	expression	expression	NOUN
ajst-25612	49	10	during	during	ADP
ajst-25612	49	11	emt	emt	PROPN
ajst-25612	49	12	involves	involve	VERB
ajst-25612	49	13	a	a	DET
ajst-25612	49	14	multitude	multitude	NOUN
ajst-25612	49	15	of	of	ADP
ajst-25612	49	16	pathways	pathway	NOUN
ajst-25612	49	17	,	,	PUNCT
ajst-25612	49	18	including	include	VERB
ajst-25612	49	19	the	the	DET
ajst-25612	49	20	activation	activation	NOUN
ajst-25612	49	21	of	of	ADP
ajst-25612	49	22	the	the	DET
ajst-25612	49	23	pi3k	pi3k	PROPN
ajst-25612	49	24	/	/	SYM
ajst-25612	49	25	akt	akt	PROPN
ajst-25612	49	26	pathway[6	pathway[6	PROPN
ajst-25612	49	27	]	]	X
ajst-25612	49	28	.	.	PUNCT
ajst-25612	50	1	consequently	consequently	ADV
ajst-25612	50	2	,	,	PUNCT
ajst-25612	50	3	the	the	DET
ajst-25612	50	4	upregulation	upregulation	NOUN
ajst-25612	50	5	of	of	ADP
ajst-25612	50	6	pd	pd	PROPN
ajst-25612	50	7	-	-	PROPN
ajst-25612	50	8	l1	l1	PROPN
ajst-25612	50	9	in	in	ADP
ajst-25612	50	10	tumor	tumor	NOUN
ajst-25612	50	11	cells	cell	NOUN
ajst-25612	50	12	facilitates	facilitate	VERB
ajst-25612	50	13	immune	immune	ADJ
ajst-25612	50	14	evasion[7	evasion[7	PROPN
ajst-25612	50	15	]	]	PUNCT
ajst-25612	50	16	.	.	PUNCT
ajst-25612	51	1	4	4	X
ajst-25612	51	2	.	.	X
ajst-25612	51	3	pi3k	pi3k	NOUN
ajst-25612	51	4	/	/	SYM
ajst-25612	51	5	akt	akt	PROPN
ajst-25612	51	6	pathway	pathway	NOUN
ajst-25612	51	7	and	and	CCONJ
ajst-25612	51	8	t	t	NOUN
ajst-25612	51	9	cell	cell	NOUN
ajst-25612	51	10	activation	activation	NOUN
ajst-25612	51	11	it	it	PRON
ajst-25612	51	12	has	have	AUX
ajst-25612	51	13	been	be	AUX
ajst-25612	51	14	demonstrated	demonstrate	VERB
ajst-25612	51	15	that	that	SCONJ
ajst-25612	51	16	the	the	DET
ajst-25612	51	17	pi3k	pi3k	PROPN
ajst-25612	51	18	/	/	SYM
ajst-25612	51	19	akt	akt	PROPN
ajst-25612	51	20	signaling	signal	VERB
ajst-25612	51	21	pathway	pathway	NOUN
ajst-25612	51	22	reduces	reduce	VERB
ajst-25612	51	23	the	the	DET
ajst-25612	51	24	likelihood	likelihood	NOUN
ajst-25612	51	25	that	that	SCONJ
ajst-25612	51	26	tumor	tumor	NOUN
ajst-25612	51	27	cells	cell	NOUN
ajst-25612	51	28	will	will	AUX
ajst-25612	51	29	be	be	AUX
ajst-25612	51	30	effectively	effectively	ADV
ajst-25612	51	31	recognized	recognize	VERB
ajst-25612	51	32	and	and	CCONJ
ajst-25612	51	33	attacked	attack	VERB
ajst-25612	51	34	by	by	ADP
ajst-25612	51	35	the	the	DET
ajst-25612	51	36	immune	immune	ADJ
ajst-25612	51	37	system	system	NOUN
ajst-25612	51	38	.	.	PUNCT
ajst-25612	52	1	this	this	PRON
ajst-25612	52	2	occurs	occur	VERB
ajst-25612	52	3	through	through	ADP
ajst-25612	52	4	its	its	PRON
ajst-25612	52	5	inhibitory	inhibitory	ADJ
ajst-25612	52	6	effect	effect	NOUN
ajst-25612	52	7	on	on	ADP
ajst-25612	52	8	t	t	PROPN
ajst-25612	52	9	cell	cell	NOUN
ajst-25612	52	10	activation	activation	NOUN
ajst-25612	52	11	.	.	PUNCT
ajst-25612	53	1	additionally	additionally	ADV
ajst-25612	53	2	,	,	PUNCT
ajst-25612	53	3	the	the	DET
ajst-25612	53	4	pathway	pathway	NOUN
ajst-25612	53	5	promotes	promote	VERB
ajst-25612	53	6	an	an	DET
ajst-25612	53	7	increase	increase	NOUN
ajst-25612	53	8	in	in	ADP
ajst-25612	53	9	the	the	DET
ajst-25612	53	10	population	population	NOUN
ajst-25612	53	11	of	of	ADP
ajst-25612	53	12	regulatory	regulatory	ADJ
ajst-25612	53	13	t	t	NOUN
ajst-25612	53	14	cells	cell	NOUN
ajst-25612	53	15	(	(	PUNCT
ajst-25612	53	16	tregs	treg	NOUN
ajst-25612	53	17	)	)	PUNCT
ajst-25612	53	18	,	,	PUNCT
ajst-25612	53	19	which	which	PRON
ajst-25612	53	20	in	in	ADP
ajst-25612	53	21	turn	turn	NOUN
ajst-25612	53	22	weakens	weaken	VERB
ajst-25612	53	23	the	the	DET
ajst-25612	53	24	overall	overall	ADJ
ajst-25612	53	25	strength	strength	NOUN
ajst-25612	53	26	of	of	ADP
ajst-25612	53	27	the	the	DET
ajst-25612	53	28	body	body	NOUN
ajst-25612	53	29	's	's	PART
ajst-25612	53	30	immune	immune	ADJ
ajst-25612	53	31	response	response	NOUN
ajst-25612	53	32	to	to	ADP
ajst-25612	53	33	tumors	tumor	NOUN
ajst-25612	53	34	.	.	PUNCT
ajst-25612	54	1	it	it	PRON
ajst-25612	54	2	is	be	AUX
ajst-25612	54	3	of	of	ADP
ajst-25612	54	4	interest	interest	NOUN
ajst-25612	54	5	to	to	PART
ajst-25612	54	6	note	note	VERB
ajst-25612	54	7	that	that	SCONJ
ajst-25612	54	8	experimental	experimental	ADJ
ajst-25612	54	9	data	datum	NOUN
ajst-25612	54	10	have	have	AUX
ajst-25612	54	11	revealed	reveal	VERB
ajst-25612	54	12	that	that	SCONJ
ajst-25612	54	13	inhibitors	inhibitor	NOUN
ajst-25612	54	14	of	of	ADP
ajst-25612	54	15	this	this	DET
ajst-25612	54	16	pathway	pathway	NOUN
ajst-25612	54	17	selectively	selectively	ADV
ajst-25612	54	18	inhibit	inhibit	VERB
ajst-25612	54	19	the	the	DET
ajst-25612	54	20	function	function	NOUN
ajst-25612	54	21	and	and	CCONJ
ajst-25612	54	22	proliferative	proliferative	ADJ
ajst-25612	54	23	activity	activity	NOUN
ajst-25612	54	24	of	of	ADP
ajst-25612	54	25	regulatory	regulatory	ADJ
ajst-25612	54	26	t	t	NOUN
ajst-25612	54	27	cells	cell	NOUN
ajst-25612	54	28	(	(	PUNCT
ajst-25612	54	29	tregs	treg	NOUN
ajst-25612	54	30	)	)	PUNCT
ajst-25612	54	31	,	,	PUNCT
ajst-25612	54	32	with	with	ADP
ajst-25612	54	33	relatively	relatively	ADV
ajst-25612	54	34	little	little	ADJ
ajst-25612	54	35	effect	effect	NOUN
ajst-25612	54	36	on	on	ADP
ajst-25612	54	37	conventional	conventional	ADJ
ajst-25612	54	38	t	t	NOUN
ajst-25612	54	39	cells[8	cells[8	PROPN
ajst-25612	54	40	]	]	PUNCT
ajst-25612	54	41	.	.	PUNCT
ajst-25612	55	1	a	a	DET
ajst-25612	55	2	series	series	NOUN
ajst-25612	55	3	of	of	ADP
ajst-25612	55	4	research	research	NOUN
ajst-25612	55	5	studies	study	NOUN
ajst-25612	55	6	clearly	clearly	ADV
ajst-25612	55	7	demonstrate	demonstrate	VERB
ajst-25612	55	8	that	that	SCONJ
ajst-25612	55	9	under	under	ADP
ajst-25612	55	10	in	in	ADP
ajst-25612	55	11	vitro	vitro	X
ajst-25612	55	12	experimental	experimental	ADJ
ajst-25612	55	13	conditions	condition	NOUN
ajst-25612	55	14	,	,	PUNCT
ajst-25612	55	15	different	different	ADJ
ajst-25612	55	16	akt	akt	NOUN
ajst-25612	55	17	and	and	CCONJ
ajst-25612	55	18	pi3k	pi3k	PROPN
ajst-25612	55	19	inhibitors	inhibitor	NOUN
ajst-25612	55	20	exhibit	exhibit	VERB
ajst-25612	55	21	significant	significant	ADJ
ajst-25612	55	22	selective	selective	ADJ
ajst-25612	55	23	inhibitory	inhibitory	ADJ
ajst-25612	55	24	effects	effect	NOUN
ajst-25612	55	25	on	on	ADP
ajst-25612	55	26	the	the	DET
ajst-25612	55	27	activation	activation	NOUN
ajst-25612	55	28	and	and	CCONJ
ajst-25612	55	29	proliferation	proliferation	NOUN
ajst-25612	55	30	of	of	ADP
ajst-25612	55	31	tregs	treg	NOUN
ajst-25612	55	32	,	,	PUNCT
ajst-25612	55	33	which	which	PRON
ajst-25612	55	34	are	be	AUX
ajst-25612	55	35	more	more	ADV
ajst-25612	55	36	precisely	precisely	ADV
ajst-25612	55	37	targeted	target	VERB
ajst-25612	55	38	compared	compare	VERB
ajst-25612	55	39	to	to	ADP
ajst-25612	55	40	normal	normal	ADJ
ajst-25612	55	41	t	t	NOUN
ajst-25612	55	42	cells	cell	NOUN
ajst-25612	55	43	.	.	PUNCT
ajst-25612	56	1	such	such	ADJ
ajst-25612	56	2	pi3k	pi3k	PROPN
ajst-25612	56	3	/	/	SYM
ajst-25612	56	4	akt	akt	PROPN
ajst-25612	56	5	inhibitors	inhibitor	NOUN
ajst-25612	56	6	possess	possess	VERB
ajst-25612	56	7	significant	significant	ADJ
ajst-25612	56	8	therapeutic	therapeutic	ADJ
ajst-25612	56	9	anti	anti	ADJ
ajst-25612	56	10	-	-	ADJ
ajst-25612	56	11	tumor	tumor	ADJ
ajst-25612	56	12	potential	potential	NOUN
ajst-25612	56	13	and	and	CCONJ
ajst-25612	56	14	their	their	PRON
ajst-25612	56	15	efficacy	efficacy	NOUN
ajst-25612	56	16	has	have	AUX
ajst-25612	56	17	been	be	AUX
ajst-25612	56	18	shown	show	VERB
ajst-25612	56	19	to	to	PART
ajst-25612	56	20	be	be	AUX
ajst-25612	56	21	directly	directly	ADV
ajst-25612	56	22	correlated	correlate	VERB
ajst-25612	56	23	with	with	ADP
ajst-25612	56	24	the	the	DET
ajst-25612	56	25	reduction	reduction	NOUN
ajst-25612	56	26	in	in	ADP
ajst-25612	56	27	the	the	DET
ajst-25612	56	28	number	number	NOUN
ajst-25612	56	29	and	and	CCONJ
ajst-25612	56	30	activity	activity	NOUN
ajst-25612	56	31	of	of	ADP
ajst-25612	56	32	tregs	treg	NOUN
ajst-25612	56	33	.	.	PUNCT
ajst-25612	57	1	in	in	ADP
ajst-25612	57	2	this	this	DET
ajst-25612	57	3	context	context	NOUN
ajst-25612	57	4	,	,	PUNCT
ajst-25612	57	5	existing	exist	VERB
ajst-25612	57	6	studies	study	NOUN
ajst-25612	57	7	have	have	AUX
ajst-25612	57	8	specifically	specifically	ADV
ajst-25612	57	9	highlighted	highlight	VERB
ajst-25612	57	10	pi3k	pi3k	PROPN
ajst-25612	57	11	/	/	SYM
ajst-25612	57	12	akt	akt	PROPN
ajst-25612	57	13	signaling	signal	VERB
ajst-25612	57	14	pathway	pathway	NOUN
ajst-25612	57	15	inhibitors	inhibitor	NOUN
ajst-25612	57	16	as	as	ADP
ajst-25612	57	17	an	an	DET
ajst-25612	57	18	effective	effective	ADJ
ajst-25612	57	19	pharmacological	pharmacological	ADJ
ajst-25612	57	20	tool	tool	NOUN
ajst-25612	57	21	for	for	ADP
ajst-25612	57	22	selective	selective	ADJ
ajst-25612	57	23	depletion	depletion	NOUN
ajst-25612	57	24	of	of	ADP
ajst-25612	57	25	inhibitory	inhibitory	ADJ
ajst-25612	57	26	tregs	treg	NOUN
ajst-25612	57	27	.	.	PUNCT
ajst-25612	58	1	such	such	ADJ
ajst-25612	58	2	inhibitors	inhibitor	NOUN
ajst-25612	58	3	are	be	AUX
ajst-25612	58	4	capable	capable	ADJ
ajst-25612	58	5	of	of	ADP
ajst-25612	58	6	effectively	effectively	ADV
ajst-25612	58	7	enhancing	enhance	VERB
ajst-25612	58	8	the	the	DET
ajst-25612	58	9	anti	anti	ADJ
ajst-25612	58	10	-	-	ADJ
ajst-25612	58	11	tumor	tumor	ADJ
ajst-25612	58	12	immune	immune	ADJ
ajst-25612	58	13	response	response	NOUN
ajst-25612	58	14	in	in	ADP
ajst-25612	58	15	the	the	DET
ajst-25612	58	16	host	host	NOUN
ajst-25612	58	17	body	body	NOUN
ajst-25612	58	18	upon	upon	SCONJ
ajst-25612	58	19	application	application	NOUN
ajst-25612	58	20	,	,	PUNCT
ajst-25612	58	21	thereby	thereby	ADV
ajst-25612	58	22	providing	provide	VERB
ajst-25612	58	23	a	a	DET
ajst-25612	58	24	compelling	compelling	ADJ
ajst-25612	58	25	rationale	rationale	NOUN
ajst-25612	58	26	for	for	ADP
ajst-25612	58	27	further	further	ADJ
ajst-25612	58	28	optimization	optimization	NOUN
ajst-25612	58	29	of	of	ADP
ajst-25612	58	30	tumor	tumor	NOUN
ajst-25612	58	31	immunotherapy	immunotherapy	NOUN
ajst-25612	58	32	strategies[9	strategies[9	NOUN
ajst-25612	58	33	]	]	PUNCT
ajst-25612	58	34	.	.	PUNCT
ajst-25612	59	1	activation	activation	NOUN
ajst-25612	59	2	of	of	ADP
ajst-25612	59	3	the	the	DET
ajst-25612	59	4	pi3k	pi3k	PROPN
ajst-25612	59	5	/	/	SYM
ajst-25612	59	6	akt	akt	PROPN
ajst-25612	59	7	pathway	pathway	NOUN
ajst-25612	59	8	can	can	AUX
ajst-25612	59	9	affect	affect	VERB
ajst-25612	59	10	antigen	antigen	ADJ
ajst-25612	59	11	presentation	presentation	NOUN
ajst-25612	59	12	and	and	CCONJ
ajst-25612	59	13	major	major	ADJ
ajst-25612	59	14	histocompatibility	histocompatibility	NOUN
ajst-25612	59	15	complex	complex	NOUN
ajst-25612	59	16	(	(	PUNCT
ajst-25612	59	17	mhc	mhc	NOUN
ajst-25612	59	18	)	)	PUNCT
ajst-25612	59	19	molecule	molecule	NOUN
ajst-25612	59	20	expression	expression	NOUN
ajst-25612	59	21	in	in	ADP
ajst-25612	59	22	tumor	tumor	NOUN
ajst-25612	59	23	cells	cell	NOUN
ajst-25612	59	24	in	in	ADP
ajst-25612	59	25	multiple	multiple	ADJ
ajst-25612	59	26	ways	way	NOUN
ajst-25612	59	27	.	.	PUNCT
ajst-25612	60	1	previous	previous	ADJ
ajst-25612	60	2	studies	study	NOUN
ajst-25612	60	3	have	have	AUX
ajst-25612	60	4	focused	focus	VERB
ajst-25612	60	5	on	on	ADP
ajst-25612	60	6	the	the	DET
ajst-25612	60	7	potential	potential	NOUN
ajst-25612	60	8	of	of	ADP
ajst-25612	60	9	pi3k	pi3k	PROPN
ajst-25612	60	10	and	and	CCONJ
ajst-25612	60	11	akt	akt	PROPN
ajst-25612	60	12	inhibitors	inhibitor	NOUN
ajst-25612	60	13	to	to	PART
ajst-25612	60	14	improve	improve	VERB
ajst-25612	60	15	tumor	tumor	NOUN
ajst-25612	60	16	immunotherapy	immunotherapy	NOUN
ajst-25612	60	17	outcomes	outcome	NOUN
ajst-25612	60	18	.	.	PUNCT
ajst-25612	61	1	inhibition	inhibition	NOUN
ajst-25612	61	2	of	of	ADP
ajst-25612	61	3	this	this	DET
ajst-25612	61	4	pathway	pathway	NOUN
ajst-25612	61	5	theoretically	theoretically	ADV
ajst-25612	61	6	allows	allow	VERB
ajst-25612	61	7	for	for	ADP
ajst-25612	61	8	the	the	DET
ajst-25612	61	9	restoration	restoration	NOUN
ajst-25612	61	10	or	or	CCONJ
ajst-25612	61	11	enhancement	enhancement	NOUN
ajst-25612	61	12	of	of	ADP
ajst-25612	61	13	tumor	tumor	NOUN
ajst-25612	61	14	cell	cell	NOUN
ajst-25612	61	15	immunogenicity	immunogenicity	NOUN
ajst-25612	61	16	,	,	PUNCT
ajst-25612	61	17	increased	increase	VERB
ajst-25612	61	18	mhc	mhc	PROPN
ajst-25612	61	19	molecule	molecule	NOUN
ajst-25612	61	20	expression	expression	NOUN
ajst-25612	61	21	,	,	PUNCT
ajst-25612	61	22	and	and	CCONJ
ajst-25612	61	23	reduced	reduce	VERB
ajst-25612	61	24	immunosuppressive	immunosuppressive	ADJ
ajst-25612	61	25	molecule	molecule	NOUN
ajst-25612	61	26	production	production	NOUN
ajst-25612	61	27	,	,	PUNCT
ajst-25612	61	28	thus	thus	ADV
ajst-25612	61	29	facilitating	facilitate	VERB
ajst-25612	61	30	more	more	ADV
ajst-25612	61	31	effective	effective	ADJ
ajst-25612	61	32	tumor	tumor	NOUN
ajst-25612	61	33	cell	cell	NOUN
ajst-25612	61	34	recognition	recognition	NOUN
ajst-25612	61	35	and	and	CCONJ
ajst-25612	61	36	attack	attack	NOUN
ajst-25612	61	37	by	by	ADP
ajst-25612	61	38	immune	immune	ADJ
ajst-25612	61	39	cells	cell	NOUN
ajst-25612	61	40	.	.	PUNCT
ajst-25612	62	1	some	some	DET
ajst-25612	62	2	pi3k	pi3k	PROPN
ajst-25612	62	3	and	and	CCONJ
ajst-25612	62	4	akt	akt	PROPN
ajst-25612	62	5	inhibitors	inhibitor	NOUN
ajst-25612	62	6	have	have	AUX
ajst-25612	62	7	demonstrated	demonstrate	VERB
ajst-25612	62	8	synergistic	synergistic	ADJ
ajst-25612	62	9	effects	effect	NOUN
ajst-25612	62	10	in	in	ADP
ajst-25612	62	11	combination	combination	NOUN
ajst-25612	62	12	with	with	ADP
ajst-25612	62	13	immune	immune	ADJ
ajst-25612	62	14	checkpoint	checkpoint	NOUN
ajst-25612	62	15	inhibitors	inhibitor	NOUN
ajst-25612	62	16	in	in	ADP
ajst-25612	62	17	clinical	clinical	ADJ
ajst-25612	62	18	trials	trial	NOUN
ajst-25612	62	19	,	,	PUNCT
ajst-25612	62	20	which	which	PRON
ajst-25612	62	21	can	can	AUX
ajst-25612	62	22	enhance	enhance	VERB
ajst-25612	62	23	the	the	DET
ajst-25612	62	24	efficacy	efficacy	NOUN
ajst-25612	62	25	of	of	ADP
ajst-25612	62	26	immunotherapy	immunotherapy	NOUN
ajst-25612	62	27	.	.	PUNCT
ajst-25612	63	1	akt	akt	PROPN
ajst-25612	63	2	can	can	AUX
ajst-25612	63	3	be	be	AUX
ajst-25612	63	4	involved	involve	VERB
ajst-25612	63	5	in	in	ADP
ajst-25612	63	6	regulating	regulate	VERB
ajst-25612	63	7	the	the	DET
ajst-25612	63	8	production	production	NOUN
ajst-25612	63	9	of	of	ADP
ajst-25612	63	10	mhc	mhc	PROPN
ajst-25612	63	11	molecules	molecule	NOUN
ajst-25612	63	12	along	along	ADP
ajst-25612	63	13	with	with	ADP
ajst-25612	63	14	various	various	ADJ
ajst-25612	63	15	proteins	protein	NOUN
ajst-25612	63	16	associated	associate	VERB
ajst-25612	63	17	with	with	ADP
ajst-25612	63	18	antigen	antigen	NOUN
ajst-25612	63	19	processing	processing	NOUN
ajst-25612	63	20	and	and	CCONJ
ajst-25612	63	21	presentation	presentation	NOUN
ajst-25612	63	22	through	through	ADP
ajst-25612	63	23	the	the	DET
ajst-25612	63	24	downstream	downstream	ADJ
ajst-25612	63	25	effector	effector	NOUN
ajst-25612	63	26	regulation	regulation	NOUN
ajst-25612	63	27	of	of	ADP
ajst-25612	63	28	factors	factor	NOUN
ajst-25612	63	29	involved	involve	VERB
ajst-25612	63	30	in	in	ADP
ajst-25612	63	31	transcription	transcription	NOUN
ajst-25612	63	32	,	,	PUNCT
ajst-25612	63	33	like	like	ADP
ajst-25612	63	34	the	the	DET
ajst-25612	63	35	nuclear	nuclear	ADJ
ajst-25612	63	36	factor	factor	NOUN
ajst-25612	63	37	κb	κb	PROPN
ajst-25612	63	38	(	(	PUNCT
ajst-25612	63	39	nf	nf	NOUN
ajst-25612	63	40	-	-	PUNCT
ajst-25612	63	41	κb	κb	NOUN
ajst-25612	63	42	)	)	PUNCT
ajst-25612	63	43	alongside	alongside	ADP
ajst-25612	63	44	signal	signal	NOUN
ajst-25612	63	45	transducer	transducer	NOUN
ajst-25612	63	46	and	and	CCONJ
ajst-25612	63	47	activator	activator	NOUN
ajst-25612	63	48	of	of	ADP
ajst-25612	63	49	transcription	transcription	NOUN
ajst-25612	63	50	3	3	NUM
ajst-25612	63	51	(	(	PUNCT
ajst-25612	63	52	stat3	stat3	NOUN
ajst-25612	63	53	)	)	PUNCT
ajst-25612	63	54	.	.	PUNCT
ajst-25612	64	1	when	when	SCONJ
ajst-25612	64	2	akt	akt	PROPN
ajst-25612	64	3	is	be	AUX
ajst-25612	64	4	hyperactive	hyperactive	ADJ
ajst-25612	64	5	,	,	PUNCT
ajst-25612	64	6	it	it	PRON
ajst-25612	64	7	may	may	AUX
ajst-25612	64	8	result	result	VERB
ajst-25612	64	9	in	in	ADP
ajst-25612	64	10	a	a	DET
ajst-25612	64	11	reduction	reduction	NOUN
ajst-25612	64	12	in	in	ADP
ajst-25612	64	13	the	the	DET
ajst-25612	64	14	expression	expression	NOUN
ajst-25612	64	15	of	of	ADP
ajst-25612	64	16	mhc	mhc	PROPN
ajst-25612	64	17	-	-	PUNCT
ajst-25612	64	18	i	i	PROPN
ajst-25612	64	19	and	and	CCONJ
ajst-25612	64	20	mhc	mhc	PROPN
ajst-25612	64	21	-	-	PUNCT
ajst-25612	64	22	ii	ii	PROPN
ajst-25612	64	23	-	-	PUNCT
ajst-25612	64	24	like	like	ADJ
ajst-25612	64	25	molecules	molecule	NOUN
ajst-25612	64	26	on	on	ADP
ajst-25612	64	27	the	the	DET
ajst-25612	64	28	surface	surface	NOUN
ajst-25612	64	29	of	of	ADP
ajst-25612	64	30	tumor	tumor	NOUN
ajst-25612	64	31	cells	cell	NOUN
ajst-25612	64	32	.	.	PUNCT
ajst-25612	65	1	this	this	PRON
ajst-25612	65	2	,	,	PUNCT
ajst-25612	65	3	in	in	ADP
ajst-25612	65	4	turn	turn	NOUN
ajst-25612	65	5	,	,	PUNCT
ajst-25612	65	6	impairs	impair	VERB
ajst-25612	65	7	the	the	DET
ajst-25612	65	8	effective	effective	ADJ
ajst-25612	65	9	presentation	presentation	NOUN
ajst-25612	65	10	of	of	ADP
ajst-25612	65	11	tumor	tumor	NOUN
ajst-25612	65	12	antigens	antigen	NOUN
ajst-25612	65	13	to	to	ADP
ajst-25612	65	14	cd8	cd8	PROPN
ajst-25612	65	15	+	+	PROPN
ajst-25612	65	16	killer	killer	PROPN
ajst-25612	65	17	t	t	PROPN
ajst-25612	65	18	cells	cell	NOUN
ajst-25612	65	19	and	and	CCONJ
ajst-25612	65	20	cd4	cd4	PROPN
ajst-25612	65	21	+	+	PROPN
ajst-25612	65	22	helper	helper	NOUN
ajst-25612	65	23	t	t	NOUN
ajst-25612	65	24	cells	cell	NOUN
ajst-25612	65	25	.	.	PUNCT
ajst-25612	66	1	consequently	consequently	ADV
ajst-25612	66	2	,	,	PUNCT
ajst-25612	66	3	the	the	DET
ajst-25612	66	4	anti	anti	ADJ
ajst-25612	66	5	-	-	ADJ
ajst-25612	66	6	tumor	tumor	ADJ
ajst-25612	66	7	function	function	NOUN
ajst-25612	66	8	of	of	ADP
ajst-25612	66	9	cd8	cd8	PROPN
ajst-25612	66	10	+	+	PROPN
ajst-25612	66	11	t	t	NOUN
ajst-25612	66	12	cells	cell	NOUN
ajst-25612	66	13	is	be	AUX
ajst-25612	66	14	diminished	diminish	VERB
ajst-25612	66	15	,	,	PUNCT
ajst-25612	66	16	recognition	recognition	NOUN
ajst-25612	66	17	and	and	CCONJ
ajst-25612	66	18	clearance	clearance	NOUN
ajst-25612	66	19	of	of	ADP
ajst-25612	66	20	tumor	tumor	NOUN
ajst-25612	66	21	cells	cell	NOUN
ajst-25612	66	22	by	by	ADP
ajst-25612	66	23	the	the	DET
ajst-25612	66	24	immune	immune	ADJ
ajst-25612	66	25	system	system	NOUN
ajst-25612	66	26	is	be	AUX
ajst-25612	66	27	impaired	impair	VERB
ajst-25612	66	28	,	,	PUNCT
ajst-25612	66	29	and	and	CCONJ
ajst-25612	66	30	immune	immune	ADJ
ajst-25612	66	31	escape	escape	NOUN
ajst-25612	66	32	is	be	AUX
ajst-25612	66	33	promoted[10	promoted[10	NOUN
ajst-25612	66	34	]	]	PUNCT
ajst-25612	66	35	.	.	PUNCT
ajst-25612	67	1	casein	casein	PROPN
ajst-25612	67	2	kinase	kinase	PROPN
ajst-25612	67	3	ii	ii	PROPN
ajst-25612	67	4	(	(	PUNCT
ajst-25612	67	5	ck2	ck2	PROPN
ajst-25612	67	6	)	)	PUNCT
ajst-25612	67	7	is	be	AUX
ajst-25612	67	8	involved	involve	VERB
ajst-25612	67	9	in	in	ADP
ajst-25612	67	10	the	the	DET
ajst-25612	67	11	promotion	promotion	NOUN
ajst-25612	67	12	of	of	ADP
ajst-25612	67	13	important	important	ADJ
ajst-25612	67	14	processes	process	NOUN
ajst-25612	67	15	such	such	ADJ
ajst-25612	67	16	as	as	ADP
ajst-25612	67	17	cell	cell	NOUN
ajst-25612	67	18	proliferation	proliferation	NOUN
ajst-25612	67	19	,	,	PUNCT
ajst-25612	67	20	invasion	invasion	NOUN
ajst-25612	67	21	,	,	PUNCT
ajst-25612	67	22	migration	migration	NOUN
ajst-25612	67	23	,	,	PUNCT
ajst-25612	67	24	apoptosis	apoptosis	NOUN
ajst-25612	67	25	,	,	PUNCT
ajst-25612	67	26	and	and	CCONJ
ajst-25612	67	27	tumor	tumor	NOUN
ajst-25612	67	28	growth	growth	NOUN
ajst-25612	67	29	through	through	ADP
ajst-25612	67	30	this	this	DET
ajst-25612	67	31	pathway	pathway	NOUN
ajst-25612	67	32	.	.	PUNCT
ajst-25612	68	1	additionally	additionally	ADV
ajst-25612	68	2	,	,	PUNCT
ajst-25612	68	3	ck2	ck2	PROPN
ajst-25612	68	4	has	have	AUX
ajst-25612	68	5	been	be	AUX
ajst-25612	68	6	found	find	VERB
ajst-25612	68	7	to	to	PART
ajst-25612	68	8	promote	promote	VERB
ajst-25612	68	9	tumor	tumor	NOUN
ajst-25612	68	10	growth	growth	NOUN
ajst-25612	68	11	by	by	ADP
ajst-25612	68	12	regulating	regulate	VERB
ajst-25612	68	13	tumorassociated	tumorassociate	VERB
ajst-25612	68	14	macrophages	macrophage	NOUN
ajst-25612	68	15	(	(	PUNCT
ajst-25612	68	16	tams	tam	NOUN
ajst-25612	68	17	)	)	PUNCT
ajst-25612	68	18	in	in	ADP
ajst-25612	68	19	the	the	DET
ajst-25612	68	20	tumor	tumor	NOUN
ajst-25612	68	21	microenvironment	microenvironment	NOUN
ajst-25612	68	22	to	to	ADP
ajst-25612	68	23	an	an	DET
ajst-25612	68	24	m2	m2	PROPN
ajst-25612	68	25	phenotype	phenotype	NOUN
ajst-25612	68	26	and	and	CCONJ
ajst-25612	68	27	reducing	reduce	VERB
ajst-25612	68	28	effector	effector	NOUN
ajst-25612	68	29	cd8	cd8	PROPN
ajst-25612	68	30	+	+	PROPN
ajst-25612	68	31	t	t	NOUN
ajst-25612	68	32	cells	cell	NOUN
ajst-25612	68	33	,	,	PUNCT
ajst-25612	68	34	thereby	thereby	ADV
ajst-25612	68	35	promoting	promote	VERB
ajst-25612	68	36	tumor	tumor	NOUN
ajst-25612	68	37	immune	immune	ADJ
ajst-25612	68	38	escape[10	escape[10	X
ajst-25612	68	39	]	]	PUNCT
ajst-25612	68	40	.	.	PUNCT
ajst-25612	69	1	as	as	ADP
ajst-25612	69	2	specialized	specialized	ADJ
ajst-25612	69	3	lymphocytes	lymphocyte	NOUN
ajst-25612	69	4	,	,	PUNCT
ajst-25612	69	5	cd8	cd8	PROPN
ajst-25612	69	6	+	+	PROPN
ajst-25612	69	7	t	t	NOUN
ajst-25612	69	8	cells	cell	NOUN
ajst-25612	69	9	are	be	AUX
ajst-25612	69	10	highly	highly	ADV
ajst-25612	69	11	adept	adept	ADJ
ajst-25612	69	12	172	172	NUM
ajst-25612	69	13	at	at	ADP
ajst-25612	69	14	recognizing	recognize	VERB
ajst-25612	69	15	and	and	CCONJ
ajst-25612	69	16	eliminating	eliminate	VERB
ajst-25612	69	17	tumor	tumor	NOUN
ajst-25612	69	18	cells	cell	NOUN
ajst-25612	69	19	and	and	CCONJ
ajst-25612	69	20	intracellular	intracellular	ADJ
ajst-25612	69	21	pathogens	pathogen	NOUN
ajst-25612	69	22	,	,	PUNCT
ajst-25612	69	23	playing	play	VERB
ajst-25612	69	24	a	a	DET
ajst-25612	69	25	pivotal	pivotal	ADJ
ajst-25612	69	26	role	role	NOUN
ajst-25612	69	27	in	in	ADP
ajst-25612	69	28	anti	anti	ADJ
ajst-25612	69	29	-	-	ADJ
ajst-25612	69	30	cancer	cancer	ADJ
ajst-25612	69	31	and	and	CCONJ
ajst-25612	69	32	antiinfection	antiinfection	NOUN
ajst-25612	69	33	immunity	immunity	NOUN
ajst-25612	69	34	.	.	PUNCT
ajst-25612	70	1	strong	strong	ADJ
ajst-25612	70	2	akt	akt	PROPN
ajst-25612	70	3	signaling	signal	VERB
ajst-25612	70	4	prompts	prompt	NOUN
ajst-25612	70	5	cd8	cd8	PROPN
ajst-25612	70	6	+	+	PROPN
ajst-25612	70	7	t	t	PROPN
ajst-25612	70	8	cells	cell	NOUN
ajst-25612	70	9	to	to	PART
ajst-25612	70	10	migrate	migrate	VERB
ajst-25612	70	11	to	to	ADP
ajst-25612	70	12	inflammatory	inflammatory	ADJ
ajst-25612	70	13	sites	site	NOUN
ajst-25612	70	14	for	for	ADP
ajst-25612	70	15	immediate	immediate	ADJ
ajst-25612	70	16	response	response	NOUN
ajst-25612	70	17	,	,	PUNCT
ajst-25612	70	18	whereas	whereas	SCONJ
ajst-25612	70	19	moderate	moderate	ADJ
ajst-25612	70	20	inhibition	inhibition	NOUN
ajst-25612	70	21	of	of	ADP
ajst-25612	70	22	akt	akt	PROPN
ajst-25612	70	23	leads	lead	VERB
ajst-25612	70	24	to	to	ADP
ajst-25612	70	25	the	the	DET
ajst-25612	70	26	differentiation	differentiation	NOUN
ajst-25612	70	27	of	of	ADP
ajst-25612	70	28	cd8	cd8	PROPN
ajst-25612	70	29	+	+	PROPN
ajst-25612	70	30	t	t	PROPN
ajst-25612	70	31	cells	cell	NOUN
ajst-25612	70	32	into	into	ADP
ajst-25612	70	33	memory	memory	NOUN
ajst-25612	70	34	t	t	PROPN
ajst-25612	70	35	cells	cell	NOUN
ajst-25612	70	36	,	,	PUNCT
ajst-25612	70	37	which	which	PRON
ajst-25612	70	38	are	be	AUX
ajst-25612	70	39	capable	capable	ADJ
ajst-25612	70	40	of	of	ADP
ajst-25612	70	41	remaining	remain	VERB
ajst-25612	70	42	latent	latent	NOUN
ajst-25612	70	43	for	for	ADP
ajst-25612	70	44	extended	extended	ADJ
ajst-25612	70	45	periods	period	NOUN
ajst-25612	70	46	and	and	CCONJ
ajst-25612	70	47	rapidly	rapidly	ADV
ajst-25612	70	48	responding	respond	VERB
ajst-25612	70	49	to	to	ADP
ajst-25612	70	50	reinfection	reinfection	NOUN
ajst-25612	70	51	,	,	PUNCT
ajst-25612	70	52	maintaining	maintain	VERB
ajst-25612	70	53	long	long	ADJ
ajst-25612	70	54	-	-	PUNCT
ajst-25612	70	55	term	term	NOUN
ajst-25612	70	56	immune	immune	ADJ
ajst-25612	70	57	memory	memory	NOUN
ajst-25612	70	58	.	.	PUNCT
ajst-25612	71	1	this	this	DET
ajst-25612	71	2	finding	finding	NOUN
ajst-25612	71	3	establishes	establish	VERB
ajst-25612	71	4	the	the	DET
ajst-25612	71	5	central	central	ADJ
ajst-25612	71	6	role	role	NOUN
ajst-25612	71	7	of	of	ADP
ajst-25612	71	8	akt	akt	PROPN
ajst-25612	71	9	signaling	signal	VERB
ajst-25612	71	10	in	in	ADP
ajst-25612	71	11	the	the	DET
ajst-25612	71	12	functional	functional	ADJ
ajst-25612	71	13	differentiation	differentiation	NOUN
ajst-25612	71	14	of	of	ADP
ajst-25612	71	15	cd8	cd8	PROPN
ajst-25612	71	16	+	+	PROPN
ajst-25612	71	17	t	t	NOUN
ajst-25612	71	18	cells	cell	NOUN
ajst-25612	71	19	as	as	ADP
ajst-25612	71	20	a	a	DET
ajst-25612	71	21	regulatory	regulatory	ADJ
ajst-25612	71	22	"	"	PUNCT
ajst-25612	71	23	switch	switch	NOUN
ajst-25612	71	24	"	"	PUNCT
ajst-25612	71	25	for	for	ADP
ajst-25612	71	26	the	the	DET
ajst-25612	71	27	balance	balance	NOUN
ajst-25612	71	28	between	between	ADP
ajst-25612	71	29	immediate	immediate	ADJ
ajst-25612	71	30	and	and	CCONJ
ajst-25612	71	31	persistent	persistent	ADJ
ajst-25612	71	32	immune	immune	ADJ
ajst-25612	71	33	responses	response	NOUN
ajst-25612	71	34	.	.	PUNCT
ajst-25612	72	1	in	in	ADP
ajst-25612	72	2	recent	recent	ADJ
ajst-25612	72	3	years	year	NOUN
ajst-25612	72	4	,	,	PUNCT
ajst-25612	72	5	studies	study	NOUN
ajst-25612	72	6	have	have	AUX
ajst-25612	72	7	shown	show	VERB
ajst-25612	72	8	that	that	SCONJ
ajst-25612	72	9	pi3k	pi3k	NOUN
ajst-25612	72	10	inhibitors	inhibitor	NOUN
ajst-25612	72	11	can	can	AUX
ajst-25612	72	12	enhance	enhance	VERB
ajst-25612	72	13	the	the	DET
ajst-25612	72	14	sensitivity	sensitivity	NOUN
ajst-25612	72	15	of	of	ADP
ajst-25612	72	16	tumor	tumor	NOUN
ajst-25612	72	17	cells	cell	NOUN
ajst-25612	72	18	to	to	ADP
ajst-25612	72	19	cd8	cd8	PROPN
ajst-25612	72	20	+	+	PROPN
ajst-25612	72	21	t	t	NOUN
ajst-25612	72	22	cells	cell	NOUN
ajst-25612	72	23	,	,	PUNCT
ajst-25612	72	24	and	and	CCONJ
ajst-25612	72	25	by	by	ADP
ajst-25612	72	26	interfering	interfere	VERB
ajst-25612	72	27	with	with	ADP
ajst-25612	72	28	tumor	tumor	NOUN
ajst-25612	72	29	metabolism	metabolism	NOUN
ajst-25612	72	30	,	,	PUNCT
ajst-25612	72	31	it	it	PRON
ajst-25612	72	32	is	be	AUX
ajst-25612	72	33	expected	expect	VERB
ajst-25612	72	34	that	that	SCONJ
ajst-25612	72	35	this	this	PRON
ajst-25612	72	36	will	will	AUX
ajst-25612	72	37	break	break	VERB
ajst-25612	72	38	through	through	ADP
ajst-25612	72	39	the	the	DET
ajst-25612	72	40	immune	immune	ADJ
ajst-25612	72	41	escape	escape	NOUN
ajst-25612	72	42	mechanism[12	mechanism[12	NOUN
ajst-25612	72	43	]	]	PUNCT
ajst-25612	72	44	.	.	PUNCT
ajst-25612	73	1	based	base	VERB
ajst-25612	73	2	on	on	ADP
ajst-25612	73	3	this	this	PRON
ajst-25612	73	4	,	,	PUNCT
ajst-25612	73	5	in	in	ADP
ajst-25612	73	6	-	-	PUNCT
ajst-25612	73	7	depth	depth	NOUN
ajst-25612	73	8	understanding	understanding	NOUN
ajst-25612	73	9	of	of	ADP
ajst-25612	73	10	the	the	DET
ajst-25612	73	11	molecular	molecular	ADJ
ajst-25612	73	12	mechanism	mechanism	NOUN
ajst-25612	73	13	of	of	ADP
ajst-25612	73	14	pi3k	pi3k	PROPN
ajst-25612	73	15	/	/	SYM
ajst-25612	73	16	akt	akt	PROPN
ajst-25612	73	17	pathway	pathway	NOUN
ajst-25612	73	18	can	can	AUX
ajst-25612	73	19	promote	promote	VERB
ajst-25612	73	20	the	the	DET
ajst-25612	73	21	development	development	NOUN
ajst-25612	73	22	of	of	ADP
ajst-25612	73	23	drugs	drug	NOUN
ajst-25612	73	24	that	that	PRON
ajst-25612	73	25	accurately	accurately	ADV
ajst-25612	73	26	regulate	regulate	VERB
ajst-25612	73	27	the	the	DET
ajst-25612	73	28	formation	formation	NOUN
ajst-25612	73	29	and	and	CCONJ
ajst-25612	73	30	the	the	DET
ajst-25612	73	31	preservation	preservation	NOUN
ajst-25612	73	32	of	of	ADP
ajst-25612	73	33	cd8+t	cd8+t	NOUN
ajst-25612	73	34	cell	cell	NOUN
ajst-25612	73	35	memory	memory	NOUN
ajst-25612	73	36	,	,	PUNCT
ajst-25612	73	37	optimize	optimize	VERB
ajst-25612	73	38	the	the	DET
ajst-25612	73	39	temporal	temporal	ADJ
ajst-25612	73	40	and	and	CCONJ
ajst-25612	73	41	spatial	spatial	ADJ
ajst-25612	73	42	distribution	distribution	NOUN
ajst-25612	73	43	of	of	ADP
ajst-25612	73	44	immune	immune	ADJ
ajst-25612	73	45	response	response	NOUN
ajst-25612	73	46	through	through	ADP
ajst-25612	73	47	fine	fine	ADJ
ajst-25612	73	48	regulation	regulation	NOUN
ajst-25612	73	49	of	of	ADP
ajst-25612	73	50	akt	akt	PROPN
ajst-25612	73	51	signal	signal	PROPN
ajst-25612	73	52	,	,	PUNCT
ajst-25612	73	53	improve	improve	VERB
ajst-25612	73	54	the	the	DET
ajst-25612	73	55	efficacy	efficacy	NOUN
ajst-25612	73	56	of	of	ADP
ajst-25612	73	57	vaccines	vaccine	NOUN
ajst-25612	73	58	,	,	PUNCT
ajst-25612	73	59	and	and	CCONJ
ajst-25612	73	60	enhance	enhance	VERB
ajst-25612	73	61	the	the	DET
ajst-25612	73	62	sustainability	sustainability	NOUN
ajst-25612	73	63	and	and	CCONJ
ajst-25612	73	64	efficiency	efficiency	NOUN
ajst-25612	73	65	of	of	ADP
ajst-25612	73	66	tumor	tumor	NOUN
ajst-25612	73	67	immunotherapy	immunotherapy	NOUN
ajst-25612	73	68	.	.	PUNCT
ajst-25612	74	1	it	it	PRON
ajst-25612	74	2	also	also	ADV
ajst-25612	74	3	provides	provide	VERB
ajst-25612	74	4	new	new	ADJ
ajst-25612	74	5	therapeutic	therapeutic	ADJ
ajst-25612	74	6	strategies	strategy	NOUN
ajst-25612	74	7	for	for	ADP
ajst-25612	74	8	a	a	DET
ajst-25612	74	9	variety	variety	NOUN
ajst-25612	74	10	of	of	ADP
ajst-25612	74	11	immune	immune	ADJ
ajst-25612	74	12	diseases[13	diseases[13	NOUN
ajst-25612	74	13	]	]	PUNCT
ajst-25612	74	14	.	.	PUNCT
ajst-25612	75	1	recent	recent	ADJ
ajst-25612	75	2	studies	study	NOUN
ajst-25612	75	3	have	have	AUX
ajst-25612	75	4	demonstrated	demonstrate	VERB
ajst-25612	75	5	that	that	SCONJ
ajst-25612	75	6	akt	akt	PROPN
ajst-25612	75	7	kinase	kinase	PROPN
ajst-25612	75	8	exhibits	exhibit	VERB
ajst-25612	75	9	heightened	heightened	ADJ
ajst-25612	75	10	activity	activity	NOUN
ajst-25612	75	11	in	in	ADP
ajst-25612	75	12	immunoresistant	immunoresistant	ADJ
ajst-25612	75	13	tumors	tumor	NOUN
ajst-25612	75	14	,	,	PUNCT
ajst-25612	75	15	particularly	particularly	ADV
ajst-25612	75	16	in	in	ADP
ajst-25612	75	17	cases	case	NOUN
ajst-25612	75	18	resistant	resistant	ADJ
ajst-25612	75	19	to	to	ADP
ajst-25612	75	20	conventional	conventional	ADJ
ajst-25612	75	21	immunotherapy	immunotherapy	NOUN
ajst-25612	75	22	.	.	PUNCT
ajst-25612	76	1	this	this	DET
ajst-25612	76	2	evidence	evidence	NOUN
ajst-25612	76	3	underscores	underscore	VERB
ajst-25612	76	4	the	the	DET
ajst-25612	76	5	pivotal	pivotal	ADJ
ajst-25612	76	6	role	role	NOUN
ajst-25612	76	7	of	of	ADP
ajst-25612	76	8	akt	akt	PROPN
ajst-25612	76	9	kinase	kinase	PROPN
ajst-25612	76	10	in	in	ADP
ajst-25612	76	11	promoting	promote	VERB
ajst-25612	76	12	tumor	tumor	NOUN
ajst-25612	76	13	immune	immune	ADJ
ajst-25612	76	14	escape	escape	NOUN
ajst-25612	76	15	.	.	PUNCT
ajst-25612	77	1	local	local	ADJ
ajst-25612	77	2	injection	injection	NOUN
ajst-25612	77	3	of	of	ADP
ajst-25612	77	4	akt	akt	PROPN
ajst-25612	77	5	inhibitors	inhibitor	NOUN
ajst-25612	77	6	into	into	ADP
ajst-25612	77	7	immunoresistant	immunoresistant	ADJ
ajst-25612	77	8	tumors	tumor	NOUN
ajst-25612	77	9	significantly	significantly	ADV
ajst-25612	77	10	enhances	enhance	VERB
ajst-25612	77	11	the	the	DET
ajst-25612	77	12	efficacy	efficacy	NOUN
ajst-25612	77	13	of	of	ADP
ajst-25612	77	14	vaccines	vaccine	NOUN
ajst-25612	77	15	or	or	CCONJ
ajst-25612	77	16	cd8	cd8	PROPN
ajst-25612	77	17	+	+	PROPN
ajst-25612	77	18	t	t	PROPN
ajst-25612	77	19	-	-	PUNCT
ajst-25612	77	20	cell	cell	NOUN
ajst-25612	77	21	therapies	therapy	NOUN
ajst-25612	77	22	targeting	target	VERB
ajst-25612	77	23	specific	specific	ADJ
ajst-25612	77	24	antigens	antigen	NOUN
ajst-25612	77	25	.	.	PUNCT
ajst-25612	78	1	this	this	PRON
ajst-25612	78	2	counteracts	counteract	VERB
ajst-25612	78	3	immunosuppression	immunosuppression	NOUN
ajst-25612	78	4	of	of	ADP
ajst-25612	78	5	the	the	DET
ajst-25612	78	6	tumor	tumor	NOUN
ajst-25612	78	7	microenvironment	microenvironment	NOUN
ajst-25612	78	8	by	by	ADP
ajst-25612	78	9	intensifying	intensify	VERB
ajst-25612	78	10	immune	immune	ADJ
ajst-25612	78	11	responses	response	NOUN
ajst-25612	78	12	against	against	ADP
ajst-25612	78	13	tumor	tumor	NOUN
ajst-25612	78	14	antigens	antigen	NOUN
ajst-25612	78	15	.	.	PUNCT
ajst-25612	79	1	atypical	atypical	ADJ
ajst-25612	79	2	triggering	triggering	NOUN
ajst-25612	79	3	of	of	ADP
ajst-25612	79	4	the	the	DET
ajst-25612	79	5	pi3k	pi3k	PROPN
ajst-25612	79	6	/	/	SYM
ajst-25612	79	7	akt	akt	PROPN
ajst-25612	79	8	signaling	signal	VERB
ajst-25612	79	9	route	route	NOUN
ajst-25612	79	10	leads	lead	VERB
ajst-25612	79	11	to	to	ADP
ajst-25612	79	12	more	more	ADJ
ajst-25612	79	13	than	than	ADP
ajst-25612	79	14	just	just	ADV
ajst-25612	79	15	tumor	tumor	NOUN
ajst-25612	79	16	growth	growth	NOUN
ajst-25612	79	17	,	,	PUNCT
ajst-25612	79	18	survival	survival	NOUN
ajst-25612	79	19	,	,	PUNCT
ajst-25612	79	20	and	and	CCONJ
ajst-25612	79	21	invasion	invasion	NOUN
ajst-25612	79	22	,	,	PUNCT
ajst-25612	79	23	but	but	CCONJ
ajst-25612	79	24	also	also	ADV
ajst-25612	79	25	promotes	promote	VERB
ajst-25612	79	26	immune	immune	ADJ
ajst-25612	79	27	escape	escape	NOUN
ajst-25612	79	28	as	as	ADP
ajst-25612	79	29	a	a	DET
ajst-25612	79	30	key	key	ADJ
ajst-25612	79	31	mechanism	mechanism	NOUN
ajst-25612	79	32	in	in	ADP
ajst-25612	79	33	immunoresistant	immunoresistant	ADJ
ajst-25612	79	34	tumors	tumor	NOUN
ajst-25612	79	35	.	.	PUNCT
ajst-25612	80	1	studying	study	VERB
ajst-25612	80	2	and	and	CCONJ
ajst-25612	80	3	intervening	intervene	VERB
ajst-25612	80	4	in	in	ADP
ajst-25612	80	5	this	this	DET
ajst-25612	80	6	pathway	pathway	NOUN
ajst-25612	80	7	is	be	AUX
ajst-25612	80	8	not	not	PART
ajst-25612	80	9	only	only	ADV
ajst-25612	80	10	essential	essential	ADJ
ajst-25612	80	11	for	for	ADP
ajst-25612	80	12	comprehending	comprehend	VERB
ajst-25612	80	13	the	the	DET
ajst-25612	80	14	intricate	intricate	ADJ
ajst-25612	80	15	mechanism	mechanism	NOUN
ajst-25612	80	16	of	of	ADP
ajst-25612	80	17	immune	immune	ADJ
ajst-25612	80	18	evasion	evasion	NOUN
ajst-25612	80	19	,	,	PUNCT
ajst-25612	80	20	but	but	CCONJ
ajst-25612	80	21	also	also	ADV
ajst-25612	80	22	offers	offer	VERB
ajst-25612	80	23	a	a	DET
ajst-25612	80	24	theoretical	theoretical	ADJ
ajst-25612	80	25	foundation	foundation	NOUN
ajst-25612	80	26	and	and	CCONJ
ajst-25612	80	27	practical	practical	ADJ
ajst-25612	80	28	guidancefor	guidancefor	ADP
ajst-25612	80	29	the	the	DET
ajst-25612	80	30	creation	creation	NOUN
ajst-25612	80	31	of	of	ADP
ajst-25612	80	32	a	a	DET
ajst-25612	80	33	new	new	ADJ
ajst-25612	80	34	immunotherapy	immunotherapy	NOUN
ajst-25612	80	35	tactics	tactic	NOUN
ajst-25612	80	36	for	for	ADP
ajst-25612	80	37	refractory	refractory	NOUN
ajst-25612	80	38	tumors[14	tumors[14	PROPN
ajst-25612	80	39	]	]	PUNCT
ajst-25612	80	40	.	.	PUNCT
ajst-25612	81	1	in	in	ADP
ajst-25612	81	2	their	their	PRON
ajst-25612	81	3	activated	activate	VERB
ajst-25612	81	4	state	state	NOUN
ajst-25612	81	5	,	,	PUNCT
ajst-25612	81	6	cd4	cd4	PROPN
ajst-25612	81	7	+	+	PROPN
ajst-25612	81	8	thymocytes	thymocyte	NOUN
ajst-25612	81	9	and	and	CCONJ
ajst-25612	81	10	peripheral	peripheral	ADJ
ajst-25612	81	11	t	t	NOUN
ajst-25612	81	12	cells	cell	NOUN
ajst-25612	81	13	are	be	AUX
ajst-25612	81	14	able	able	ADJ
ajst-25612	81	15	to	to	PART
ajst-25612	81	16	regain	regain	VERB
ajst-25612	81	17	the	the	DET
ajst-25612	81	18	ability	ability	NOUN
ajst-25612	81	19	to	to	PART
ajst-25612	81	20	express	express	VERB
ajst-25612	81	21	a	a	DET
ajst-25612	81	22	key	key	ADJ
ajst-25612	81	23	transcription	transcription	NOUN
ajst-25612	81	24	factor	factor	NOUN
ajst-25612	81	25	(	(	PUNCT
ajst-25612	81	26	foxp3	foxp3	NOUN
ajst-25612	81	27	)	)	PUNCT
ajst-25612	81	28	for	for	ADP
ajst-25612	81	29	tregs	treg	NOUN
ajst-25612	81	30	function	function	NOUN
ajst-25612	81	31	in	in	ADP
ajst-25612	81	32	a	a	DET
ajst-25612	81	33	pathway	pathway	NOUN
ajst-25612	81	34	independent	independent	ADJ
ajst-25612	81	35	of	of	ADP
ajst-25612	81	36	transforming	transform	VERB
ajst-25612	81	37	growth	growth	NOUN
ajst-25612	81	38	factor	factor	NOUN
ajst-25612	81	39	-	-	PUNCT
ajst-25612	81	40	β	β	X
ajst-25612	81	41	(	(	PUNCT
ajst-25612	81	42	tgf	tgf	PROPN
ajst-25612	81	43	-	-	PUNCT
ajst-25612	81	44	β	β	NOUN
ajst-25612	81	45	)	)	PUNCT
ajst-25612	81	46	.	.	PUNCT
ajst-25612	82	1	this	this	DET
ajst-25612	82	2	pathway	pathway	NOUN
ajst-25612	82	3	is	be	AUX
ajst-25612	82	4	none	none	NOUN
ajst-25612	82	5	other	other	ADJ
ajst-25612	82	6	than	than	ADP
ajst-25612	82	7	the	the	DET
ajst-25612	82	8	pi3k	pi3k	PROPN
ajst-25612	82	9	/	/	SYM
ajst-25612	82	10	akt	akt	PROPN
ajst-25612	82	11	/	/	SYM
ajst-25612	82	12	mtor	mtor	PROPN
ajst-25612	82	13	signaling	signal	VERB
ajst-25612	82	14	pathway	pathway	NOUN
ajst-25612	82	15	,	,	PUNCT
ajst-25612	82	16	which	which	PRON
ajst-25612	82	17	is	be	AUX
ajst-25612	82	18	a	a	DET
ajst-25612	82	19	core	core	NOUN
ajst-25612	82	20	pathway	pathway	NOUN
ajst-25612	82	21	for	for	ADP
ajst-25612	82	22	tregs	treg	NOUN
ajst-25612	82	23	activation	activation	NOUN
ajst-25612	82	24	and	and	CCONJ
ajst-25612	82	25	function	function	NOUN
ajst-25612	82	26	.	.	PUNCT
ajst-25612	83	1	previous	previous	ADJ
ajst-25612	83	2	studies	study	NOUN
ajst-25612	83	3	have	have	AUX
ajst-25612	83	4	shown	show	VERB
ajst-25612	83	5	that	that	SCONJ
ajst-25612	83	6	this	this	DET
ajst-25612	83	7	pathway	pathway	NOUN
ajst-25612	83	8	promotes	promote	VERB
ajst-25612	83	9	radiation	radiation	NOUN
ajst-25612	83	10	resistance	resistance	NOUN
ajst-25612	83	11	.	.	PUNCT
ajst-25612	84	1	the	the	DET
ajst-25612	84	2	pdk1	pdk1	NOUN
ajst-25612	84	3	-	-	PUNCT
ajst-25612	84	4	driven	drive	VERB
ajst-25612	84	5	radioresistance	radioresistance	NOUN
ajst-25612	84	6	in	in	ADP
ajst-25612	84	7	hepatocellular	hepatocellular	ADJ
ajst-25612	84	8	carcinoma	carcinoma	NOUN
ajst-25612	84	9	is	be	AUX
ajst-25612	84	10	associated	associate	VERB
ajst-25612	84	11	with	with	ADP
ajst-25612	84	12	the	the	DET
ajst-25612	84	13	activation	activation	NOUN
ajst-25612	84	14	of	of	ADP
ajst-25612	84	15	the	the	DET
ajst-25612	84	16	pi3k	pi3k	PROPN
ajst-25612	84	17	pathway	pathway	NOUN
ajst-25612	84	18	.	.	PUNCT
ajst-25612	85	1	in	in	ADP
ajst-25612	85	2	addition	addition	NOUN
ajst-25612	85	3	,	,	PUNCT
ajst-25612	85	4	this	this	DET
ajst-25612	85	5	pathway	pathway	NOUN
ajst-25612	85	6	is	be	AUX
ajst-25612	85	7	usually	usually	ADV
ajst-25612	85	8	activated	activate	VERB
ajst-25612	85	9	,	,	PUNCT
ajst-25612	85	10	leading	lead	VERB
ajst-25612	85	11	to	to	ADP
ajst-25612	85	12	radiation	radiation	NOUN
ajst-25612	85	13	resistance	resistance	NOUN
ajst-25612	85	14	in	in	ADP
ajst-25612	85	15	glioblastoma	glioblastoma	NOUN
ajst-25612	85	16	cells[15	cells[15	NOUN
ajst-25612	85	17	]	]	PUNCT
ajst-25612	85	18	.	.	PUNCT
ajst-25612	86	1	inhibition	inhibition	NOUN
ajst-25612	86	2	of	of	ADP
ajst-25612	86	3	this	this	DET
ajst-25612	86	4	signaling	signal	VERB
ajst-25612	86	5	network	network	NOUN
ajst-25612	86	6	was	be	AUX
ajst-25612	86	7	able	able	ADJ
ajst-25612	86	8	to	to	PART
ajst-25612	86	9	induce	induce	VERB
ajst-25612	86	10	the	the	DET
ajst-25612	86	11	re	re	NOUN
ajst-25612	86	12	-	-	NOUN
ajst-25612	86	13	expression	expression	NOUN
ajst-25612	86	14	of	of	ADP
ajst-25612	86	15	foxp3	foxp3	NOUN
ajst-25612	86	16	and	and	CCONJ
ajst-25612	86	17	its	its	PRON
ajst-25612	86	18	associated	associated	ADJ
ajst-25612	86	19	characteristic	characteristic	ADJ
ajst-25612	86	20	treg	treg	PROPN
ajst-25612	86	21	cell	cell	PROPN
ajst-25612	86	22	mrnas	mrnas	PROPN
ajst-25612	86	23	,	,	PUNCT
ajst-25612	86	24	implicating	implicate	VERB
ajst-25612	86	25	a	a	DET
ajst-25612	86	26	critical	critical	ADJ
ajst-25612	86	27	role	role	NOUN
ajst-25612	86	28	for	for	ADP
ajst-25612	86	29	this	this	DET
ajst-25612	86	30	pathway	pathway	NOUN
ajst-25612	86	31	in	in	ADP
ajst-25612	86	32	maintaining	maintain	VERB
ajst-25612	86	33	the	the	DET
ajst-25612	86	34	treg	treg	PROPN
ajst-25612	86	35	cell	cell	NOUN
ajst-25612	86	36	phenotype	phenotype	NOUN
ajst-25612	86	37	.	.	PUNCT
ajst-25612	87	1	in	in	ADP
ajst-25612	87	2	contrast	contrast	NOUN
ajst-25612	87	3	,	,	PUNCT
ajst-25612	87	4	the	the	DET
ajst-25612	87	5	efficiency	efficiency	NOUN
ajst-25612	87	6	of	of	ADP
ajst-25612	87	7	foxp3	foxp3	NOUN
ajst-25612	87	8	induction	induction	NOUN
ajst-25612	87	9	was	be	AUX
ajst-25612	87	10	reduced	reduce	VERB
ajst-25612	87	11	in	in	ADP
ajst-25612	87	12	pten	pten	ADJ
ajst-25612	87	13	-	-	PUNCT
ajst-25612	87	14	deficient	deficient	ADJ
ajst-25612	87	15	t	t	NOUN
ajst-25612	87	16	cells	cell	NOUN
ajst-25612	87	17	due	due	ADP
ajst-25612	87	18	to	to	ADP
ajst-25612	87	19	persistent	persistent	ADJ
ajst-25612	87	20	activation	activation	NOUN
ajst-25612	87	21	of	of	ADP
ajst-25612	87	22	this	this	DET
ajst-25612	87	23	pathway	pathway	NOUN
ajst-25612	87	24	.	.	PUNCT
ajst-25612	88	1	therefore	therefore	ADV
ajst-25612	88	2	,	,	PUNCT
ajst-25612	88	3	the	the	DET
ajst-25612	88	4	efficient	efficient	ADJ
ajst-25612	88	5	induction	induction	NOUN
ajst-25612	88	6	of	of	ADP
ajst-25612	88	7	foxp3	foxp3	NOUN
ajst-25612	88	8	can	can	AUX
ajst-25612	88	9	be	be	AUX
ajst-25612	88	10	restored	restore	VERB
ajst-25612	88	11	by	by	ADP
ajst-25612	88	12	inhibiting	inhibit	VERB
ajst-25612	88	13	pi3k	pi3k	NOUN
ajst-25612	88	14	,	,	PUNCT
ajst-25612	88	15	which	which	PRON
ajst-25612	88	16	is	be	AUX
ajst-25612	88	17	valuable	valuable	ADJ
ajst-25612	88	18	for	for	ADP
ajst-25612	88	19	an	an	DET
ajst-25612	88	20	in	in	ADP
ajst-25612	88	21	-	-	PUNCT
ajst-25612	88	22	depth	depth	NOUN
ajst-25612	88	23	understanding	understanding	NOUN
ajst-25612	88	24	of	of	ADP
ajst-25612	88	25	the	the	DET
ajst-25612	88	26	mechanism	mechanism	NOUN
ajst-25612	88	27	of	of	ADP
ajst-25612	88	28	tregs	treg	NOUN
ajst-25612	88	29	generation	generation	NOUN
ajst-25612	88	30	and	and	CCONJ
ajst-25612	88	31	the	the	DET
ajst-25612	88	32	design	design	NOUN
ajst-25612	88	33	of	of	ADP
ajst-25612	88	34	intervention	intervention	NOUN
ajst-25612	88	35	strategies	strategy	NOUN
ajst-25612	88	36	to	to	PART
ajst-25612	88	37	maintain	maintain	VERB
ajst-25612	88	38	immune	immune	ADJ
ajst-25612	88	39	homeostasis[16	homeostasis[16	NOUN
ajst-25612	88	40	]	]	PUNCT
ajst-25612	88	41	.	.	PUNCT
ajst-25612	89	1	the	the	DET
ajst-25612	89	2	pathway	pathway	NOUN
ajst-25612	89	3	involving	involve	VERB
ajst-25612	89	4	pi3k	pi3k	PROPN
ajst-25612	89	5	/	/	SYM
ajst-25612	89	6	akt	akt	PROPN
ajst-25612	89	7	/	/	SYM
ajst-25612	89	8	mtor	mtor	PROPN
ajst-25612	89	9	signaling	signal	VERB
ajst-25612	89	10	holds	hold	VERB
ajst-25612	89	11	a	a	DET
ajst-25612	89	12	crucial	crucial	ADJ
ajst-25612	89	13	regulatory	regulatory	ADJ
ajst-25612	89	14	position	position	NOUN
ajst-25612	89	15	in	in	ADP
ajst-25612	89	16	numerous	numerous	ADJ
ajst-25612	89	17	cell	cell	NOUN
ajst-25612	89	18	physiological	physiological	ADJ
ajst-25612	89	19	activities	activity	NOUN
ajst-25612	89	20	,	,	PUNCT
ajst-25612	89	21	encompassing	encompass	VERB
ajst-25612	89	22	a	a	DET
ajst-25612	89	23	broad	broad	ADJ
ajst-25612	89	24	spectrum	spectrum	NOUN
ajst-25612	89	25	of	of	ADP
ajst-25612	89	26	cell	cell	NOUN
ajst-25612	89	27	proliferation	proliferation	NOUN
ajst-25612	89	28	and	and	CCONJ
ajst-25612	89	29	metabolism	metabolism	NOUN
ajst-25612	89	30	.	.	PUNCT
ajst-25612	90	1	in	in	ADP
ajst-25612	90	2	particular	particular	ADJ
ajst-25612	90	3	,	,	PUNCT
ajst-25612	90	4	activation	activation	NOUN
ajst-25612	90	5	of	of	ADP
ajst-25612	90	6	pi3k	pi3k	PROPN
ajst-25612	90	7	plays	play	VERB
ajst-25612	90	8	a	a	DET
ajst-25612	90	9	key	key	ADJ
ajst-25612	90	10	role	role	NOUN
ajst-25612	90	11	in	in	ADP
ajst-25612	90	12	t	t	NOUN
ajst-25612	90	13	cells	cell	NOUN
ajst-25612	90	14	.	.	PUNCT
ajst-25612	91	1	it	it	PRON
ajst-25612	91	2	not	not	PART
ajst-25612	91	3	only	only	ADV
ajst-25612	91	4	contributes	contribute	VERB
ajst-25612	91	5	to	to	ADP
ajst-25612	91	6	the	the	DET
ajst-25612	91	7	cell	cell	NOUN
ajst-25612	91	8	survival	survival	NOUN
ajst-25612	91	9	and	and	CCONJ
ajst-25612	91	10	proliferation	proliferation	NOUN
ajst-25612	91	11	process	process	NOUN
ajst-25612	91	12	,	,	PUNCT
ajst-25612	91	13	but	but	CCONJ
ajst-25612	91	14	also	also	ADV
ajst-25612	91	15	profoundly	profoundly	ADV
ajst-25612	91	16	affects	affect	VERB
ajst-25612	91	17	t	t	PROPN
ajst-25612	91	18	cell	cell	NOUN
ajst-25612	91	19	differentiation	differentiation	NOUN
ajst-25612	91	20	and	and	CCONJ
ajst-25612	91	21	is	be	AUX
ajst-25612	91	22	essential	essential	ADJ
ajst-25612	91	23	for	for	ADP
ajst-25612	91	24	determining	determine	VERB
ajst-25612	91	25	the	the	DET
ajst-25612	91	26	phenotype	phenotype	NOUN
ajst-25612	91	27	of	of	ADP
ajst-25612	91	28	effector	effector	NOUN
ajst-25612	91	29	and	and	CCONJ
ajst-25612	91	30	memory	memory	NOUN
ajst-25612	91	31	t	t	NOUN
ajst-25612	91	32	cells	cell	NOUN
ajst-25612	91	33	.	.	PUNCT
ajst-25612	92	1	consequently	consequently	ADV
ajst-25612	92	2	,	,	PUNCT
ajst-25612	92	3	inhibitors	inhibitor	NOUN
ajst-25612	92	4	of	of	ADP
ajst-25612	92	5	this	this	DET
ajst-25612	92	6	pathway	pathway	NOUN
ajst-25612	92	7	can	can	AUX
ajst-25612	92	8	effectively	effectively	ADV
ajst-25612	92	9	intervene	intervene	VERB
ajst-25612	92	10	in	in	ADP
ajst-25612	92	11	the	the	DET
ajst-25612	92	12	activation	activation	NOUN
ajst-25612	92	13	state	state	NOUN
ajst-25612	92	14	and	and	CCONJ
ajst-25612	92	15	functional	functional	ADJ
ajst-25612	92	16	manifestation	manifestation	NOUN
ajst-25612	92	17	of	of	ADP
ajst-25612	92	18	t	t	NOUN
ajst-25612	92	19	cells	cell	NOUN
ajst-25612	92	20	.	.	PUNCT
ajst-25612	93	1	pi3k	pi3k	NOUN
ajst-25612	93	2	inhibitors	inhibitor	NOUN
ajst-25612	93	3	have	have	AUX
ajst-25612	93	4	demonstrated	demonstrate	VERB
ajst-25612	93	5	considerable	considerable	ADJ
ajst-25612	93	6	potential	potential	NOUN
ajst-25612	93	7	in	in	ADP
ajst-25612	93	8	the	the	DET
ajst-25612	93	9	treatment	treatment	NOUN
ajst-25612	93	10	of	of	ADP
ajst-25612	93	11	t	t	NOUN
ajst-25612	93	12	cell	cell	NOUN
ajst-25612	93	13	-	-	PUNCT
ajst-25612	93	14	mediated	mediate	VERB
ajst-25612	93	15	diseases	disease	NOUN
ajst-25612	93	16	.	.	PUNCT
ajst-25612	94	1	this	this	DET
ajst-25612	94	2	class	class	NOUN
ajst-25612	94	3	of	of	ADP
ajst-25612	94	4	drugs	drug	NOUN
ajst-25612	94	5	is	be	AUX
ajst-25612	94	6	particularly	particularly	ADV
ajst-25612	94	7	important	important	ADJ
ajst-25612	94	8	in	in	ADP
ajst-25612	94	9	the	the	DET
ajst-25612	94	10	field	field	NOUN
ajst-25612	94	11	of	of	ADP
ajst-25612	94	12	allogeneic	allogeneic	ADJ
ajst-25612	94	13	hematopoietic	hematopoietic	ADJ
ajst-25612	94	14	stem	stem	NOUN
ajst-25612	94	15	cells	cell	NOUN
ajst-25612	94	16	transplantation	transplantation	NOUN
ajst-25612	94	17	,	,	PUNCT
ajst-25612	94	18	where	where	SCONJ
ajst-25612	94	19	they	they	PRON
ajst-25612	94	20	can	can	AUX
ajst-25612	94	21	be	be	AUX
ajst-25612	94	22	used	use	VERB
ajst-25612	94	23	to	to	PART
ajst-25612	94	24	target	target	VERB
ajst-25612	94	25	the	the	DET
ajst-25612	94	26	regulation	regulation	NOUN
ajst-25612	94	27	of	of	ADP
ajst-25612	94	28	t	t	NOUN
ajst-25612	94	29	cell	cell	NOUN
ajst-25612	94	30	function	function	NOUN
ajst-25612	94	31	and	and	CCONJ
ajst-25612	94	32	possible	possible	ADJ
ajst-25612	94	33	antileukemic	antileukemic	ADJ
ajst-25612	94	34	effects	effect	NOUN
ajst-25612	94	35	.	.	PUNCT
ajst-25612	95	1	the	the	DET
ajst-25612	95	2	administration	administration	NOUN
ajst-25612	95	3	of	of	ADP
ajst-25612	95	4	pi3k	pi3k	PROPN
ajst-25612	95	5	inhibitors	inhibitor	NOUN
ajst-25612	95	6	represents	represent	VERB
ajst-25612	95	7	an	an	DET
ajst-25612	95	8	efficacious	efficacious	ADJ
ajst-25612	95	9	approach	approach	NOUN
ajst-25612	95	10	to	to	PART
ajst-25612	95	11	intervene	intervene	VERB
ajst-25612	95	12	in	in	ADP
ajst-25612	95	13	this	this	DET
ajst-25612	95	14	pathway	pathway	NOUN
ajst-25612	95	15	.	.	PUNCT
ajst-25612	96	1	by	by	ADP
ajst-25612	96	2	interfering	interfere	VERB
ajst-25612	96	3	with	with	ADP
ajst-25612	96	4	this	this	DET
ajst-25612	96	5	pathway	pathway	NOUN
ajst-25612	96	6	,	,	PUNCT
ajst-25612	96	7	pi3k	pi3k	PROPN
ajst-25612	96	8	inhibitors	inhibitor	NOUN
ajst-25612	96	9	can	can	AUX
ajst-25612	96	10	modulate	modulate	VERB
ajst-25612	96	11	inappropriate	inappropriate	ADJ
ajst-25612	96	12	immune	immune	ADJ
ajst-25612	96	13	responses	response	NOUN
ajst-25612	96	14	and	and	CCONJ
ajst-25612	96	15	enhance	enhance	VERB
ajst-25612	96	16	the	the	DET
ajst-25612	96	17	ability	ability	NOUN
ajst-25612	96	18	to	to	PART
ajst-25612	96	19	clear	clear	VERB
ajst-25612	96	20	residual	residual	ADJ
ajst-25612	96	21	leukemia	leukemia	NOUN
ajst-25612	96	22	cells	cell	NOUN
ajst-25612	96	23	after	after	ADP
ajst-25612	96	24	transplantation	transplantation	NOUN
ajst-25612	96	25	.	.	PUNCT
ajst-25612	97	1	this	this	PRON
ajst-25612	97	2	,	,	PUNCT
ajst-25612	97	3	in	in	ADP
ajst-25612	97	4	turn	turn	NOUN
ajst-25612	97	5	,	,	PUNCT
ajst-25612	97	6	improves	improve	VERB
ajst-25612	97	7	patient	patient	ADJ
ajst-25612	97	8	prognosis	prognosis	NOUN
ajst-25612	97	9	and	and	CCONJ
ajst-25612	97	10	quality	quality	NOUN
ajst-25612	97	11	of	of	ADP
ajst-25612	97	12	life[17	life[17	PROPN
ajst-25612	97	13	]	]	PUNCT
ajst-25612	97	14	.	.	PUNCT
ajst-25612	98	1	recent	recent	ADJ
ajst-25612	98	2	studies	study	NOUN
ajst-25612	98	3	have	have	AUX
ajst-25612	98	4	demonstrated	demonstrate	VERB
ajst-25612	98	5	that	that	SCONJ
ajst-25612	98	6	in	in	ADP
ajst-25612	98	7	low	low	ADJ
ajst-25612	98	8	-	-	PUNCT
ajst-25612	98	9	dose	dose	NOUN
ajst-25612	98	10	photodynamic	photodynamic	ADJ
ajst-25612	98	11	therapy	therapy	NOUN
ajst-25612	98	12	(	(	PUNCT
ajst-25612	98	13	pdt	pdt	PROPN
ajst-25612	98	14	)	)	PUNCT
ajst-25612	98	15	of	of	ADP
ajst-25612	98	16	llc	llc	PROPN
ajst-25612	98	17	cells	cell	NOUN
ajst-25612	98	18	,	,	PUNCT
ajst-25612	98	19	precise	precise	ADJ
ajst-25612	98	20	regulation	regulation	NOUN
ajst-25612	98	21	of	of	ADP
ajst-25612	98	22	the	the	DET
ajst-25612	98	23	pi3k	pi3k	PROPN
ajst-25612	98	24	/	/	SYM
ajst-25612	98	25	akt	akt	PROPN
ajst-25612	98	26	signaling	signal	VERB
ajst-25612	98	27	pathway	pathway	NOUN
ajst-25612	98	28	results	result	NOUN
ajst-25612	98	29	in	in	ADP
ajst-25612	98	30	elevated	elevated	ADJ
ajst-25612	98	31	levels	level	NOUN
ajst-25612	98	32	of	of	ADP
ajst-25612	98	33	hif-1α	hif-1α	NOUN
ajst-25612	98	34	protein	protein	NOUN
ajst-25612	98	35	,	,	PUNCT
ajst-25612	98	36	which	which	PRON
ajst-25612	98	37	enhances	enhance	VERB
ajst-25612	98	38	the	the	DET
ajst-25612	98	39	cell	cell	NOUN
ajst-25612	98	40	's	's	PART
ajst-25612	98	41	immune	immune	ADJ
ajst-25612	98	42	escape	escape	NOUN
ajst-25612	98	43	ability	ability	NOUN
ajst-25612	98	44	.	.	PUNCT
ajst-25612	99	1	although	although	SCONJ
ajst-25612	99	2	this	this	DET
ajst-25612	99	3	treatment	treatment	NOUN
ajst-25612	99	4	is	be	AUX
ajst-25612	99	5	relatively	relatively	ADV
ajst-25612	99	6	mild	mild	ADJ
ajst-25612	99	7	,	,	PUNCT
ajst-25612	99	8	it	it	PRON
ajst-25612	99	9	may	may	AUX
ajst-25612	99	10	have	have	VERB
ajst-25612	99	11	the	the	DET
ajst-25612	99	12	unintended	unintended	ADJ
ajst-25612	99	13	consequence	consequence	NOUN
ajst-25612	99	14	of	of	ADP
ajst-25612	99	15	impairing	impair	VERB
ajst-25612	99	16	the	the	DET
ajst-25612	99	17	body	body	NOUN
ajst-25612	99	18	's	's	PART
ajst-25612	99	19	immune	immune	ADJ
ajst-25612	99	20	clearance	clearance	NOUN
ajst-25612	99	21	of	of	ADP
ajst-25612	99	22	tumor	tumor	NOUN
ajst-25612	99	23	cells	cell	NOUN
ajst-25612	99	24	.	.	PUNCT
ajst-25612	100	1	activation	activation	NOUN
ajst-25612	100	2	of	of	ADP
ajst-25612	100	3	this	this	DET
ajst-25612	100	4	pathway	pathway	NOUN
ajst-25612	100	5	not	not	PART
ajst-25612	100	6	only	only	ADV
ajst-25612	100	7	supports	support	VERB
ajst-25612	100	8	the	the	DET
ajst-25612	100	9	stability	stability	NOUN
ajst-25612	100	10	and	and	CCONJ
ajst-25612	100	11	activity	activity	NOUN
ajst-25612	100	12	of	of	ADP
ajst-25612	100	13	hif-1α	hif-1α	NOUN
ajst-25612	100	14	,	,	PUNCT
ajst-25612	100	15	but	but	CCONJ
ajst-25612	100	16	also	also	ADV
ajst-25612	100	17	indirectly	indirectly	ADV
ajst-25612	100	18	affects	affect	VERB
ajst-25612	100	19	immune	immune	ADJ
ajst-25612	100	20	cells	cell	NOUN
ajst-25612	100	21	.	.	PUNCT
ajst-25612	101	1	this	this	PRON
ajst-25612	101	2	has	have	AUX
ajst-25612	101	3	become	become	VERB
ajst-25612	101	4	a	a	DET
ajst-25612	101	5	new	new	ADJ
ajst-25612	101	6	strategy	strategy	NOUN
ajst-25612	101	7	for	for	ADP
ajst-25612	101	8	tumor	tumor	NOUN
ajst-25612	101	9	cells	cell	NOUN
ajst-25612	101	10	to	to	PART
ajst-25612	101	11	evade	evade	VERB
ajst-25612	101	12	immune	immune	ADJ
ajst-25612	101	13	surveillance	surveillance	NOUN
ajst-25612	101	14	using	use	VERB
ajst-25612	101	15	low	low	ADJ
ajst-25612	101	16	-	-	PUNCT
ajst-25612	101	17	dose	dose	NOUN
ajst-25612	101	18	pdt[18	pdt[18	PROPN
ajst-25612	101	19	]	]	PUNCT
ajst-25612	101	20	.	.	PUNCT
ajst-25612	102	1	in	in	ADP
ajst-25612	102	2	b	b	PROPN
ajst-25612	102	3	cells	cell	NOUN
ajst-25612	102	4	,	,	PUNCT
ajst-25612	102	5	pi3k	pi3k	NOUN
ajst-25612	102	6	deficiency	deficiency	NOUN
ajst-25612	102	7	has	have	VERB
ajst-25612	102	8	a	a	DET
ajst-25612	102	9	profound	profound	ADJ
ajst-25612	102	10	impact	impact	NOUN
ajst-25612	102	11	on	on	ADP
ajst-25612	102	12	development	development	NOUN
ajst-25612	102	13	and	and	CCONJ
ajst-25612	102	14	antigen	antigen	ADJ
ajst-25612	102	15	response	response	NOUN
ajst-25612	102	16	.	.	PUNCT
ajst-25612	103	1	in	in	ADP
ajst-25612	103	2	contrast	contrast	NOUN
ajst-25612	103	3	,	,	PUNCT
ajst-25612	103	4	t	t	PROPN
ajst-25612	103	5	cell	cell	NOUN
ajst-25612	103	6	development	development	NOUN
ajst-25612	103	7	,	,	PUNCT
ajst-25612	103	8	immune	immune	ADJ
ajst-25612	103	9	function	function	NOUN
ajst-25612	103	10	,	,	PUNCT
ajst-25612	103	11	and	and	CCONJ
ajst-25612	103	12	migration	migration	NOUN
ajst-25612	103	13	dynamics	dynamic	NOUN
ajst-25612	103	14	are	be	AUX
ajst-25612	103	15	regulated	regulate	VERB
ajst-25612	103	16	by	by	ADP
ajst-25612	103	17	pi3k	pi3k	PROPN
ajst-25612	103	18	,	,	PUNCT
ajst-25612	103	19	which	which	PRON
ajst-25612	103	20	is	be	AUX
ajst-25612	103	21	also	also	ADV
ajst-25612	103	22	involved	involve	VERB
ajst-25612	103	23	in	in	ADP
ajst-25612	103	24	regulatory	regulatory	ADJ
ajst-25612	103	25	t	t	NOUN
ajst-25612	103	26	cell	cell	NOUN
ajst-25612	103	27	homeostasis	homeostasis	NOUN
ajst-25612	103	28	.	.	PUNCT
ajst-25612	104	1	these	these	DET
ajst-25612	104	2	findings	finding	NOUN
ajst-25612	104	3	suggest	suggest	VERB
ajst-25612	104	4	that	that	SCONJ
ajst-25612	104	5	the	the	DET
ajst-25612	104	6	pi3k	pi3k	NOUN
ajst-25612	104	7	signaling	signal	VERB
ajst-25612	104	8	pathway	pathway	NOUN
ajst-25612	104	9	is	be	AUX
ajst-25612	104	10	the	the	DET
ajst-25612	104	11	pathway	pathway	NOUN
ajst-25612	104	12	is	be	AUX
ajst-25612	104	13	complex	complex	ADJ
ajst-25612	104	14	and	and	CCONJ
ajst-25612	104	15	not	not	PART
ajst-25612	104	16	a	a	DET
ajst-25612	104	17	single	single	ADJ
ajst-25612	104	18	activation	activation	NOUN
ajst-25612	104	19	mechanism	mechanism	NOUN
ajst-25612	104	20	.	.	PUNCT
ajst-25612	105	1	t	t	PROPN
ajst-25612	105	2	cell	cell	NOUN
ajst-25612	105	3	autoimmune	autoimmune	NOUN
ajst-25612	105	4	responses	response	NOUN
ajst-25612	105	5	in	in	ADP
ajst-25612	105	6	the	the	DET
ajst-25612	105	7	pi3kdeficient	pi3kdeficient	PROPN
ajst-25612	105	8	mouse	mouse	PROPN
ajst-25612	105	9	model	model	NOUN
ajst-25612	105	10	suggest	suggest	VERB
ajst-25612	105	11	that	that	SCONJ
ajst-25612	105	12	pi3k	pi3k	NOUN
ajst-25612	105	13	signaling	signal	VERB
ajst-25612	105	14	is	be	AUX
ajst-25612	105	15	essential	essential	ADJ
ajst-25612	105	16	for	for	ADP
ajst-25612	105	17	maintaining	maintain	VERB
ajst-25612	105	18	immune	immune	ADJ
ajst-25612	105	19	system	system	NOUN
ajst-25612	105	20	homeostasis	homeostasis	NOUN
ajst-25612	105	21	and	and	CCONJ
ajst-25612	105	22	proper	proper	ADJ
ajst-25612	105	23	response	response	NOUN
ajst-25612	105	24	,	,	PUNCT
ajst-25612	105	25	emphasizing	emphasize	VERB
ajst-25612	105	26	the	the	DET
ajst-25612	105	27	need	need	NOUN
ajst-25612	105	28	for	for	ADP
ajst-25612	105	29	balanced	balanced	ADJ
ajst-25612	105	30	regulation	regulation	NOUN
ajst-25612	105	31	of	of	ADP
ajst-25612	105	32	this	this	DET
ajst-25612	105	33	pathway[19	pathway[19	NOUN
ajst-25612	105	34	]	]	PUNCT
ajst-25612	105	35	.	.	PUNCT
ajst-25612	106	1	5	5	X
ajst-25612	106	2	.	.	X
ajst-25612	106	3	pi3k	pi3k	NOUN
ajst-25612	106	4	/	/	SYM
ajst-25612	106	5	akt	akt	PROPN
ajst-25612	106	6	pathway	pathway	NOUN
ajst-25612	106	7	and	and	CCONJ
ajst-25612	106	8	cancer	cancer	NOUN
ajst-25612	106	9	treatment	treatment	NOUN
ajst-25612	106	10	the	the	DET
ajst-25612	106	11	level	level	NOUN
ajst-25612	106	12	of	of	ADP
ajst-25612	106	13	activity	activity	NOUN
ajst-25612	106	14	of	of	ADP
ajst-25612	106	15	the	the	DET
ajst-25612	106	16	pi3k	pi3k	PROPN
ajst-25612	106	17	/	/	SYM
ajst-25612	106	18	akt	akt	PROPN
ajst-25612	106	19	signaling	signal	VERB
ajst-25612	106	20	pathway	pathway	NOUN
ajst-25612	106	21	exhibits	exhibit	VERB
ajst-25612	106	22	considerable	considerable	ADJ
ajst-25612	106	23	variability	variability	NOUN
ajst-25612	106	24	across	across	ADP
ajst-25612	106	25	different	different	ADJ
ajst-25612	106	26	cancer	cancer	NOUN
ajst-25612	106	27	types	type	NOUN
ajst-25612	106	28	.	.	PUNCT
ajst-25612	107	1	the	the	DET
ajst-25612	107	2	pathway	pathway	NOUN
ajst-25612	107	3	is	be	AUX
ajst-25612	107	4	frequently	frequently	ADV
ajst-25612	107	5	demonstrated	demonstrate	VERB
ajst-25612	107	6	to	to	PART
ajst-25612	107	7	be	be	AUX
ajst-25612	107	8	hyperactivated	hyperactivate	VERB
ajst-25612	107	9	in	in	ADP
ajst-25612	107	10	a	a	DET
ajst-25612	107	11	multitude	multitude	NOUN
ajst-25612	107	12	of	of	ADP
ajst-25612	107	13	cancer	cancer	NOUN
ajst-25612	107	14	types	type	NOUN
ajst-25612	107	15	,	,	PUNCT
ajst-25612	107	16	including	include	VERB
ajst-25612	107	17	ovarian	ovarian	ADJ
ajst-25612	107	18	,	,	PUNCT
ajst-25612	107	19	endometrial	endometrial	ADJ
ajst-25612	107	20	,	,	PUNCT
ajst-25612	107	21	breast	breast	NOUN
ajst-25612	107	22	,	,	PUNCT
ajst-25612	107	23	gastric	gastric	ADJ
ajst-25612	107	24	,	,	PUNCT
ajst-25612	107	25	and	and	CCONJ
ajst-25612	107	26	gliomas	glioma	NOUN
ajst-25612	107	27	.	.	PUNCT
ajst-25612	108	1	this	this	DET
ajst-25612	108	2	hyperactivation	hyperactivation	NOUN
ajst-25612	108	3	may	may	AUX
ajst-25612	108	4	be	be	AUX
ajst-25612	108	5	caused	cause	VERB
ajst-25612	108	6	by	by	ADP
ajst-25612	108	7	a	a	DET
ajst-25612	108	8	variety	variety	NOUN
ajst-25612	108	9	of	of	ADP
ajst-25612	108	10	genetic	genetic	ADJ
ajst-25612	108	11	and	and	CCONJ
ajst-25612	108	12	epigenetic	epigenetic	ADJ
ajst-25612	108	13	changes	change	NOUN
ajst-25612	108	14	,	,	PUNCT
ajst-25612	108	15	including	include	VERB
ajst-25612	108	16	,	,	PUNCT
ajst-25612	108	17	but	but	CCONJ
ajst-25612	108	18	not	not	PART
ajst-25612	108	19	limited	limit	VERB
ajst-25612	108	20	to	to	ADP
ajst-25612	108	21	,	,	PUNCT
ajst-25612	108	22	mutations	mutation	NOUN
ajst-25612	108	23	in	in	ADP
ajst-25612	108	24	the	the	DET
ajst-25612	108	25	pi3k	pi3k	PROPN
ajst-25612	108	26	catalytic	catalytic	ADJ
ajst-25612	108	27	subunit	subunit	NOUN
ajst-25612	108	28	genes	gene	NOUN
ajst-25612	108	29	,	,	PUNCT
ajst-25612	108	30	amplification	amplification	NOUN
ajst-25612	108	31	of	of	ADP
ajst-25612	108	32	the	the	DET
ajst-25612	108	33	akt	akt	PROPN
ajst-25612	108	34	gene	gene	NOUN
ajst-25612	108	35	,	,	PUNCT
ajst-25612	108	36	or	or	CCONJ
ajst-25612	108	37	inactivation	inactivation	NOUN
ajst-25612	108	38	of	of	ADP
ajst-25612	108	39	the	the	DET
ajst-25612	108	40	pten	pten	ADJ
ajst-25612	108	41	oncogene	oncogene	NOUN
ajst-25612	108	42	.	.	PUNCT
ajst-25612	109	1	these	these	DET
ajst-25612	109	2	differences	difference	NOUN
ajst-25612	109	3	reflect	reflect	VERB
ajst-25612	109	4	the	the	DET
ajst-25612	109	5	heterogeneity	heterogeneity	NOUN
ajst-25612	109	6	of	of	ADP
ajst-25612	109	7	tumorigenesis	tumorigenesis	NOUN
ajst-25612	109	8	and	and	CCONJ
ajst-25612	109	9	may	may	AUX
ajst-25612	109	10	also	also	ADV
ajst-25612	109	11	determine	determine	VERB
ajst-25612	109	12	the	the	DET
ajst-25612	109	13	different	different	ADJ
ajst-25612	109	14	propensities	propensity	NOUN
ajst-25612	109	15	of	of	ADP
ajst-25612	109	16	different	different	ADJ
ajst-25612	109	17	tumors	tumor	NOUN
ajst-25612	109	18	for	for	ADP
ajst-25612	109	19	growth	growth	NOUN
ajst-25612	109	20	,	,	PUNCT
ajst-25612	109	21	invasion	invasion	NOUN
ajst-25612	109	22	,	,	PUNCT
ajst-25612	109	23	metastasis	metastasis	NOUN
ajst-25612	109	24	,	,	PUNCT
ajst-25612	109	25	and	and	CCONJ
ajst-25612	109	26	resistance	resistance	NOUN
ajst-25612	109	27	to	to	AUX
ajst-25612	109	28	apoptosis	apoptosis	VERB
ajst-25612	109	29	.	.	PUNCT
ajst-25612	110	1	in	in	ADP
ajst-25612	110	2	ovarian	ovarian	ADJ
ajst-25612	110	3	cancer	cancer	NOUN
ajst-25612	110	4	research	research	NOUN
ajst-25612	110	5	,	,	PUNCT
ajst-25612	110	6	phosphorylated	phosphorylate	VERB
ajst-25612	110	7	forms	form	NOUN
ajst-25612	110	8	of	of	ADP
ajst-25612	110	9	akt	akt	PROPN
ajst-25612	110	10	and	and	CCONJ
ajst-25612	110	11	mtor	mtor	PROPN
ajst-25612	110	12	,	,	PUNCT
ajst-25612	110	13	both	both	PRON
ajst-25612	110	14	of	of	ADP
ajst-25612	110	15	which	which	PRON
ajst-25612	110	16	play	play	VERB
ajst-25612	110	17	key	key	ADJ
ajst-25612	110	18	roles	role	NOUN
ajst-25612	110	19	in	in	ADP
ajst-25612	110	20	the	the	DET
ajst-25612	110	21	proliferation	proliferation	NOUN
ajst-25612	110	22	of	of	ADP
ajst-25612	110	23	ovarian	ovarian	ADJ
ajst-25612	110	24	cancer	cancer	NOUN
ajst-25612	110	25	cells	cell	NOUN
ajst-25612	110	26	,	,	PUNCT
ajst-25612	110	27	have	have	AUX
ajst-25612	110	28	been	be	AUX
ajst-25612	110	29	frequently	frequently	ADV
ajst-25612	110	30	observed	observe	VERB
ajst-25612	110	31	.	.	PUNCT
ajst-25612	111	1	this	this	PRON
ajst-25612	111	2	serves	serve	VERB
ajst-25612	111	3	as	as	ADP
ajst-25612	111	4	a	a	DET
ajst-25612	111	5	potential	potential	ADJ
ajst-25612	111	6	target	target	NOUN
ajst-25612	111	7	for	for	ADP
ajst-25612	111	8	intervening	intervene	VERB
ajst-25612	111	9	in	in	ADP
ajst-25612	111	10	the	the	DET
ajst-25612	111	11	growth	growth	NOUN
ajst-25612	111	12	of	of	ADP
ajst-25612	111	13	ovarian	ovarian	ADJ
ajst-25612	111	14	tumors	tumor	NOUN
ajst-25612	111	15	.	.	PUNCT
ajst-25612	112	1	akt	akt	PROPN
ajst-25612	112	2	,	,	PUNCT
ajst-25612	112	3	an	an	DET
ajst-25612	112	4	important	important	ADJ
ajst-25612	112	5	cell	cell	NOUN
ajst-25612	112	6	survival	survival	NOUN
ajst-25612	112	7	signaling	signal	VERB
ajst-25612	112	8	173	173	NUM
ajst-25612	112	9	mediator	mediator	NOUN
ajst-25612	112	10	that	that	PRON
ajst-25612	112	11	is	be	AUX
ajst-25612	112	12	often	often	ADV
ajst-25612	112	13	hyperactivated	hyperactivate	VERB
ajst-25612	112	14	in	in	ADP
ajst-25612	112	15	primary	primary	ADJ
ajst-25612	112	16	ovarian	ovarian	ADJ
ajst-25612	112	17	cancer	cancer	NOUN
ajst-25612	112	18	cases	case	NOUN
ajst-25612	112	19	,	,	PUNCT
ajst-25612	112	20	plays	play	VERB
ajst-25612	112	21	a	a	DET
ajst-25612	112	22	central	central	ADJ
ajst-25612	112	23	role	role	NOUN
ajst-25612	112	24	in	in	ADP
ajst-25612	112	25	the	the	DET
ajst-25612	112	26	maintenance	maintenance	NOUN
ajst-25612	112	27	of	of	ADP
ajst-25612	112	28	ovarian	ovarian	ADJ
ajst-25612	112	29	cancer	cancer	NOUN
ajst-25612	112	30	cells	cell	NOUN
ajst-25612	112	31	to	to	PART
ajst-25612	112	32	escape	escape	VERB
ajst-25612	112	33	programmed	program	VERB
ajst-25612	112	34	cell	cell	NOUN
ajst-25612	112	35	death	death	NOUN
ajst-25612	112	36	,	,	PUNCT
ajst-25612	112	37	which	which	PRON
ajst-25612	112	38	is	be	AUX
ajst-25612	112	39	also	also	ADV
ajst-25612	112	40	known	know	VERB
ajst-25612	112	41	as	as	ADP
ajst-25612	112	42	apoptosis	apoptosis	NOUN
ajst-25612	112	43	.	.	PUNCT
ajst-25612	113	1	consequently	consequently	ADV
ajst-25612	113	2	,	,	PUNCT
ajst-25612	113	3	pharmacological	pharmacological	ADJ
ajst-25612	113	4	strategies	strategy	NOUN
ajst-25612	113	5	aimed	aim	VERB
ajst-25612	113	6	at	at	ADP
ajst-25612	113	7	blocking	block	VERB
ajst-25612	113	8	the	the	DET
ajst-25612	113	9	akt	akt	NOUN
ajst-25612	113	10	signaling	signal	VERB
ajst-25612	113	11	pathway	pathway	NOUN
ajst-25612	113	12	could	could	AUX
ajst-25612	113	13	theoretically	theoretically	ADV
ajst-25612	113	14	preferentially	preferentially	ADV
ajst-25612	113	15	target	target	VERB
ajst-25612	113	16	ovarian	ovarian	ADJ
ajst-25612	113	17	cancer	cancer	NOUN
ajst-25612	113	18	cells	cell	NOUN
ajst-25612	113	19	that	that	PRON
ajst-25612	113	20	are	be	AUX
ajst-25612	113	21	highly	highly	ADV
ajst-25612	113	22	dependent	dependent	ADJ
ajst-25612	113	23	on	on	ADP
ajst-25612	113	24	akt	akt	PROPN
ajst-25612	113	25	activity	activity	NOUN
ajst-25612	113	26	to	to	PART
ajst-25612	113	27	maintain	maintain	VERB
ajst-25612	113	28	their	their	PRON
ajst-25612	113	29	survival	survival	NOUN
ajst-25612	113	30	status	status	NOUN
ajst-25612	113	31	.	.	PUNCT
ajst-25612	114	1	in	in	ADP
ajst-25612	114	2	contrast	contrast	NOUN
ajst-25612	114	3	,	,	PUNCT
ajst-25612	114	4	normal	normal	ADJ
ajst-25612	114	5	non	non	ADJ
ajst-25612	114	6	-	-	ADJ
ajst-25612	114	7	cancerous	cancerous	ADJ
ajst-25612	114	8	cells	cell	NOUN
ajst-25612	114	9	do	do	AUX
ajst-25612	114	10	not	not	PART
ajst-25612	114	11	rely	rely	VERB
ajst-25612	114	12	heavily	heavily	ADV
ajst-25612	114	13	on	on	ADP
ajst-25612	114	14	the	the	DET
ajst-25612	114	15	continuous	continuous	ADJ
ajst-25612	114	16	activation	activation	NOUN
ajst-25612	114	17	of	of	ADP
ajst-25612	114	18	akt	akt	PROPN
ajst-25612	114	19	to	to	PART
ajst-25612	114	20	maintain	maintain	VERB
ajst-25612	114	21	their	their	PRON
ajst-25612	114	22	survival	survival	NOUN
ajst-25612	114	23	.	.	PUNCT
ajst-25612	115	1	such	such	ADJ
ajst-25612	115	2	pharmacological	pharmacological	ADJ
ajst-25612	115	3	intervention	intervention	NOUN
ajst-25612	115	4	is	be	AUX
ajst-25612	115	5	anticipated	anticipate	VERB
ajst-25612	115	6	to	to	PART
ajst-25612	115	7	result	result	VERB
ajst-25612	115	8	in	in	ADP
ajst-25612	115	9	the	the	DET
ajst-25612	115	10	selective	selective	ADJ
ajst-25612	115	11	elimination	elimination	NOUN
ajst-25612	115	12	of	of	ADP
ajst-25612	115	13	ovarian	ovarian	ADJ
ajst-25612	115	14	cancer	cancer	NOUN
ajst-25612	115	15	cells	cell	NOUN
ajst-25612	115	16	,	,	PUNCT
ajst-25612	115	17	an	an	DET
ajst-25612	115	18	improvement	improvement	NOUN
ajst-25612	115	19	in	in	ADP
ajst-25612	115	20	therapeutic	therapeutic	ADJ
ajst-25612	115	21	efficacy	efficacy	NOUN
ajst-25612	115	22	,	,	PUNCT
ajst-25612	115	23	and	and	CCONJ
ajst-25612	115	24	a	a	DET
ajst-25612	115	25	reduction	reduction	NOUN
ajst-25612	115	26	in	in	ADP
ajst-25612	115	27	adverse	adverse	ADJ
ajst-25612	115	28	effects	effect	NOUN
ajst-25612	115	29	on	on	ADP
ajst-25612	115	30	normal	normal	ADJ
ajst-25612	115	31	tissues[8	tissues[8	PROPN
ajst-25612	115	32	]	]	PUNCT
ajst-25612	115	33	.	.	PUNCT
ajst-25612	116	1	in	in	ADP
ajst-25612	116	2	the	the	DET
ajst-25612	116	3	field	field	NOUN
ajst-25612	116	4	of	of	ADP
ajst-25612	116	5	endometrial	endometrial	ADJ
ajst-25612	116	6	cancer	cancer	NOUN
ajst-25612	116	7	research	research	NOUN
ajst-25612	116	8	,	,	PUNCT
ajst-25612	116	9	indoleamine	indoleamine	NOUN
ajst-25612	116	10	2,3	2,3	NUM
ajst-25612	116	11	-	-	NOUN
ajst-25612	116	12	dioxygenase	dioxygenase	NOUN
ajst-25612	116	13	(	(	PUNCT
ajst-25612	116	14	ido	ido	PROPN
ajst-25612	116	15	)	)	PUNCT
ajst-25612	116	16	plays	play	VERB
ajst-25612	116	17	a	a	DET
ajst-25612	116	18	pivotal	pivotal	ADJ
ajst-25612	116	19	role	role	NOUN
ajst-25612	116	20	in	in	ADP
ajst-25612	116	21	the	the	DET
ajst-25612	116	22	complex	complex	ADJ
ajst-25612	116	23	process	process	NOUN
ajst-25612	116	24	of	of	ADP
ajst-25612	116	25	tumor	tumor	NOUN
ajst-25612	116	26	immune	immune	ADJ
ajst-25612	116	27	escape	escape	NOUN
ajst-25612	116	28	.	.	PUNCT
ajst-25612	117	1	the	the	DET
ajst-25612	117	2	activity	activity	NOUN
ajst-25612	117	3	of	of	ADP
ajst-25612	117	4	this	this	DET
ajst-25612	117	5	enzyme	enzyme	NOUN
ajst-25612	117	6	is	be	AUX
ajst-25612	117	7	particularly	particularly	ADV
ajst-25612	117	8	closely	closely	ADV
ajst-25612	117	9	related	relate	VERB
ajst-25612	117	10	to	to	ADP
ajst-25612	117	11	its	its	PRON
ajst-25612	117	12	interaction	interaction	NOUN
ajst-25612	117	13	with	with	ADP
ajst-25612	117	14	the	the	DET
ajst-25612	117	15	pathway	pathway	NOUN
ajst-25612	117	16	involving	involve	VERB
ajst-25612	117	17	pi3k	pi3k	PROPN
ajst-25612	117	18	/	/	SYM
ajst-25612	117	19	akt	akt	PROPN
ajst-25612	117	20	signaling	signal	VERB
ajst-25612	117	21	.	.	PUNCT
ajst-25612	118	1	further	further	ADJ
ajst-25612	118	2	researches	research	NOUN
ajst-25612	118	3	have	have	AUX
ajst-25612	118	4	indicated	indicate	VERB
ajst-25612	118	5	that	that	SCONJ
ajst-25612	118	6	the	the	DET
ajst-25612	118	7	expression	expression	NOUN
ajst-25612	118	8	level	level	NOUN
ajst-25612	118	9	of	of	ADP
ajst-25612	118	10	ido	ido	NOUN
ajst-25612	118	11	can	can	AUX
ajst-25612	118	12	be	be	AUX
ajst-25612	118	13	indirectly	indirectly	ADV
ajst-25612	118	14	affected	affect	VERB
ajst-25612	118	15	by	by	ADP
ajst-25612	118	16	regulating	regulate	VERB
ajst-25612	118	17	the	the	DET
ajst-25612	118	18	activity	activity	NOUN
ajst-25612	118	19	status	status	NOUN
ajst-25612	118	20	of	of	ADP
ajst-25612	118	21	cyclooxygenase-2	cyclooxygenase-2	NUM
ajst-25612	118	22	(	(	PUNCT
ajst-25612	118	23	cox-2	cox-2	NOUN
ajst-25612	118	24	)	)	PUNCT
ajst-25612	118	25	in	in	ADP
ajst-25612	118	26	the	the	DET
ajst-25612	118	27	tumor	tumor	NOUN
ajst-25612	118	28	microenvironment	microenvironment	NOUN
ajst-25612	118	29	.	.	PUNCT
ajst-25612	119	1	consequently	consequently	ADV
ajst-25612	119	2	,	,	PUNCT
ajst-25612	119	3	the	the	DET
ajst-25612	119	4	interaction	interaction	NOUN
ajst-25612	119	5	between	between	ADP
ajst-25612	119	6	tumor	tumor	NOUN
ajst-25612	119	7	immune	immune	ADJ
ajst-25612	119	8	escape	escape	NOUN
ajst-25612	119	9	strategies	strategy	NOUN
ajst-25612	119	10	and	and	CCONJ
ajst-25612	119	11	the	the	DET
ajst-25612	119	12	pi3k	pi3k	PROPN
ajst-25612	119	13	/	/	SYM
ajst-25612	119	14	akt	akt	PROPN
ajst-25612	119	15	signaling	signal	VERB
ajst-25612	119	16	pathway	pathway	NOUN
ajst-25612	119	17	,	,	PUNCT
ajst-25612	119	18	which	which	PRON
ajst-25612	119	19	together	together	ADV
ajst-25612	119	20	drive	drive	VERB
ajst-25612	119	21	powerful	powerful	ADJ
ajst-25612	119	22	adaptations	adaptation	NOUN
ajst-25612	119	23	for	for	ADP
ajst-25612	119	24	tumor	tumor	NOUN
ajst-25612	119	25	survival	survival	NOUN
ajst-25612	119	26	and	and	CCONJ
ajst-25612	119	27	development	development	NOUN
ajst-25612	119	28	in	in	ADP
ajst-25612	119	29	vivo	vivo	NOUN
ajst-25612	119	30	,	,	PUNCT
ajst-25612	119	31	appears	appear	VERB
ajst-25612	119	32	particularly	particularly	ADV
ajst-25612	119	33	prominent[20	prominent[20	NOUN
ajst-25612	119	34	]	]	PUNCT
ajst-25612	119	35	.	.	PUNCT
ajst-25612	120	1	in	in	ADP
ajst-25612	120	2	breast	breast	NOUN
ajst-25612	120	3	cancer	cancer	NOUN
ajst-25612	120	4	research	research	NOUN
ajst-25612	120	5	,	,	PUNCT
ajst-25612	120	6	vimofenib	vimofenib	NOUN
ajst-25612	120	7	inhibits	inhibit	VERB
ajst-25612	120	8	the	the	DET
ajst-25612	120	9	expression	expression	NOUN
ajst-25612	120	10	of	of	ADP
ajst-25612	120	11	the	the	DET
ajst-25612	120	12	breast	breast	NOUN
ajst-25612	120	13	cancer	cancer	NOUN
ajst-25612	120	14	immune	immune	ADJ
ajst-25612	120	15	escape	escape	NOUN
ajst-25612	120	16	biomarker	biomarker	NOUN
ajst-25612	120	17	bcl2a1	bcl2a1	NOUN
ajst-25612	120	18	by	by	ADP
ajst-25612	120	19	targeting	target	VERB
ajst-25612	120	20	the	the	DET
ajst-25612	120	21	pi3k	pi3k	PROPN
ajst-25612	120	22	/	/	SYM
ajst-25612	120	23	akt	akt	PROPN
ajst-25612	120	24	signaling	signal	VERB
ajst-25612	120	25	pathway	pathway	NOUN
ajst-25612	120	26	and	and	CCONJ
ajst-25612	120	27	inhibiting	inhibit	VERB
ajst-25612	120	28	breast	breast	NOUN
ajst-25612	120	29	cancer	cancer	NOUN
ajst-25612	120	30	cell	cell	NOUN
ajst-25612	120	31	growth[21	growth[21	PROPN
ajst-25612	120	32	]	]	PUNCT
ajst-25612	120	33	.	.	PUNCT
ajst-25612	121	1	mutations	mutation	NOUN
ajst-25612	121	2	in	in	ADP
ajst-25612	121	3	the	the	DET
ajst-25612	121	4	pathway	pathway	NOUN
ajst-25612	121	5	involving	involve	VERB
ajst-25612	121	6	pi3k	pi3k	PROPN
ajst-25612	121	7	/	/	SYM
ajst-25612	121	8	akt	akt	PROPN
ajst-25612	121	9	/	/	SYM
ajst-25612	121	10	mtor	mtor	PROPN
ajst-25612	121	11	signaling	signal	VERB
ajst-25612	121	12	have	have	AUX
ajst-25612	121	13	been	be	AUX
ajst-25612	121	14	identified	identify	VERB
ajst-25612	121	15	as	as	ADP
ajst-25612	121	16	predictors	predictor	NOUN
ajst-25612	121	17	of	of	ADP
ajst-25612	121	18	immune	immune	ADJ
ajst-25612	121	19	cell	cell	NOUN
ajst-25612	121	20	infiltration	infiltration	NOUN
ajst-25612	121	21	and	and	CCONJ
ajst-25612	121	22	immunotherapy	immunotherapy	NOUN
ajst-25612	121	23	response	response	NOUN
ajst-25612	121	24	in	in	ADP
ajst-25612	121	25	gastric	gastric	ADJ
ajst-25612	121	26	adenocarcinoma	adenocarcinoma	NOUN
ajst-25612	121	27	studies[22	studies[22	NOUN
ajst-25612	121	28	]	]	PUNCT
ajst-25612	121	29	.	.	PUNCT
ajst-25612	122	1	in	in	ADP
ajst-25612	122	2	gastric	gastric	ADJ
ajst-25612	122	3	cancer	cancer	NOUN
ajst-25612	122	4	research	research	NOUN
ajst-25612	122	5	,	,	PUNCT
ajst-25612	122	6	it	it	PRON
ajst-25612	122	7	has	have	AUX
ajst-25612	122	8	been	be	AUX
ajst-25612	122	9	demonstrated	demonstrate	VERB
ajst-25612	122	10	that	that	SCONJ
ajst-25612	122	11	il8	il8	NOUN
ajst-25612	122	12	,	,	PUNCT
ajst-25612	122	13	which	which	PRON
ajst-25612	122	14	is	be	AUX
ajst-25612	122	15	induced	induce	VERB
ajst-25612	122	16	by	by	ADP
ajst-25612	122	17	h.	h.	PROPN
ajst-25612	122	18	pylori	pylori	ADJ
ajst-25612	122	19	infection	infection	NOUN
ajst-25612	122	20	,	,	PUNCT
ajst-25612	122	21	can	can	AUX
ajst-25612	122	22	create	create	VERB
ajst-25612	122	23	a	a	DET
ajst-25612	122	24	microenvironment	microenvironment	NOUN
ajst-25612	122	25	conducive	conducive	ADJ
ajst-25612	122	26	to	to	ADP
ajst-25612	122	27	immune	immune	ADJ
ajst-25612	122	28	escape	escape	NOUN
ajst-25612	122	29	in	in	ADP
ajst-25612	122	30	gastric	gastric	ADJ
ajst-25612	122	31	cancer	cancer	NOUN
ajst-25612	122	32	cells	cell	NOUN
ajst-25612	122	33	by	by	ADP
ajst-25612	122	34	activating	activate	VERB
ajst-25612	122	35	the	the	DET
ajst-25612	122	36	pi3k	pi3k	PROPN
ajst-25612	122	37	/	/	SYM
ajst-25612	122	38	akt	akt	PROPN
ajst-25612	122	39	signaling	signal	VERB
ajst-25612	122	40	pathway	pathway	NOUN
ajst-25612	122	41	.	.	PUNCT
ajst-25612	123	1	this	this	PRON
ajst-25612	123	2	,	,	PUNCT
ajst-25612	123	3	in	in	ADP
ajst-25612	123	4	turn	turn	NOUN
ajst-25612	123	5	,	,	PUNCT
ajst-25612	123	6	up	up	ADV
ajst-25612	123	7	-	-	PUNCT
ajst-25612	123	8	regulates	regulate	VERB
ajst-25612	123	9	the	the	DET
ajst-25612	123	10	expression	expression	NOUN
ajst-25612	123	11	of	of	ADP
ajst-25612	123	12	pd	pd	PROPN
ajst-25612	123	13	-	-	PROPN
ajst-25612	123	14	l1	l1	PROPN
ajst-25612	123	15	.	.	PUNCT
ajst-25612	124	1	the	the	DET
ajst-25612	124	2	pi3k	pi3k	PROPN
ajst-25612	124	3	/	/	SYM
ajst-25612	124	4	akt	akt	PROPN
ajst-25612	124	5	/	/	SYM
ajst-25612	124	6	pd	pd	PROPN
ajst-25612	124	7	-	-	PROPN
ajst-25612	124	8	l1	l1	PROPN
ajst-25612	124	9	signaling	signal	VERB
ajst-25612	124	10	axis	axis	NOUN
ajst-25612	124	11	is	be	AUX
ajst-25612	124	12	the	the	DET
ajst-25612	124	13	mechanism	mechanism	NOUN
ajst-25612	124	14	through	through	ADP
ajst-25612	124	15	which	which	PRON
ajst-25612	124	16	il-8	il-8	PRON
ajst-25612	124	17	exerts	exert	VERB
ajst-25612	124	18	its	its	PRON
ajst-25612	124	19	immune	immune	ADJ
ajst-25612	124	20	-	-	PUNCT
ajst-25612	124	21	suppressive	suppressive	NOUN
ajst-25612	124	22	effects	effect	NOUN
ajst-25612	124	23	on	on	ADP
ajst-25612	124	24	gastric	gastric	ADJ
ajst-25612	124	25	cancer	cancer	NOUN
ajst-25612	124	26	cells	cell	NOUN
ajst-25612	124	27	.	.	PUNCT
ajst-25612	125	1	this	this	PRON
ajst-25612	125	2	effectively	effectively	ADV
ajst-25612	125	3	inhibits	inhibit	VERB
ajst-25612	125	4	the	the	DET
ajst-25612	125	5	recognition	recognition	NOUN
ajst-25612	125	6	and	and	CCONJ
ajst-25612	125	7	killing	kill	VERB
ajst-25612	125	8	efficacy	efficacy	NOUN
ajst-25612	125	9	of	of	ADP
ajst-25612	125	10	killer	killer	PROPN
ajst-25612	125	11	t	t	PROPN
ajst-25612	125	12	cells	cell	NOUN
ajst-25612	125	13	on	on	ADP
ajst-25612	125	14	gastric	gastric	ADJ
ajst-25612	125	15	cancer	cancer	NOUN
ajst-25612	125	16	cells[23	cells[23	NOUN
ajst-25612	125	17	]	]	PUNCT
ajst-25612	125	18	.	.	PUNCT
ajst-25612	126	1	in	in	ADP
ajst-25612	126	2	glioma	glioma	NOUN
ajst-25612	126	3	research	research	NOUN
ajst-25612	126	4	,	,	PUNCT
ajst-25612	126	5	it	it	PRON
ajst-25612	126	6	has	have	AUX
ajst-25612	126	7	been	be	AUX
ajst-25612	126	8	demonstrated	demonstrate	VERB
ajst-25612	126	9	that	that	SCONJ
ajst-25612	126	10	the	the	DET
ajst-25612	126	11	loss	loss	NOUN
ajst-25612	126	12	of	of	ADP
ajst-25612	126	13	the	the	DET
ajst-25612	126	14	pten	pten	ADJ
ajst-25612	126	15	gene	gene	NOUN
ajst-25612	126	16	can	can	AUX
ajst-25612	126	17	lead	lead	VERB
ajst-25612	126	18	to	to	ADP
ajst-25612	126	19	the	the	DET
ajst-25612	126	20	dysregulated	dysregulated	ADJ
ajst-25612	126	21	activation	activation	NOUN
ajst-25612	126	22	of	of	ADP
ajst-25612	126	23	the	the	DET
ajst-25612	126	24	pathway	pathway	NOUN
ajst-25612	126	25	involving	involve	VERB
ajst-25612	126	26	pi3k	pi3k	PROPN
ajst-25612	126	27	/	/	SYM
ajst-25612	126	28	akt	akt	PROPN
ajst-25612	126	29	signaling	signal	VERB
ajst-25612	126	30	.	.	PUNCT
ajst-25612	127	1	this	this	DET
ajst-25612	127	2	aberrant	aberrant	ADJ
ajst-25612	127	3	activation	activation	NOUN
ajst-25612	127	4	process	process	NOUN
ajst-25612	127	5	is	be	AUX
ajst-25612	127	6	not	not	PART
ajst-25612	127	7	only	only	ADV
ajst-25612	127	8	accompanied	accompany	VERB
ajst-25612	127	9	by	by	ADP
ajst-25612	127	10	an	an	DET
ajst-25612	127	11	overproduction	overproduction	NOUN
ajst-25612	127	12	of	of	ADP
ajst-25612	127	13	pro	pro	ADJ
ajst-25612	127	14	-	-	ADJ
ajst-25612	127	15	inflammatory	inflammatory	ADJ
ajst-25612	127	16	cytokines	cytokine	NOUN
ajst-25612	127	17	,	,	PUNCT
ajst-25612	127	18	but	but	CCONJ
ajst-25612	127	19	also	also	ADV
ajst-25612	127	20	significantly	significantly	ADV
ajst-25612	127	21	impairs	impair	VERB
ajst-25612	127	22	the	the	DET
ajst-25612	127	23	effective	effective	ADJ
ajst-25612	127	24	infiltration	infiltration	NOUN
ajst-25612	127	25	and	and	CCONJ
ajst-25612	127	26	activation	activation	NOUN
ajst-25612	127	27	of	of	ADP
ajst-25612	127	28	cd8	cd8	PROPN
ajst-25612	127	29	+	+	PROPN
ajst-25612	127	30	cytotoxic	cytotoxic	ADJ
ajst-25612	127	31	t	t	NOUN
ajst-25612	127	32	-	-	PUNCT
ajst-25612	127	33	cells	cell	NOUN
ajst-25612	127	34	into	into	ADP
ajst-25612	127	35	tumor	tumor	NOUN
ajst-25612	127	36	tissues	tissue	NOUN
ajst-25612	127	37	in	in	ADP
ajst-25612	127	38	melanoma	melanoma	NOUN
ajst-25612	127	39	patients	patient	NOUN
ajst-25612	127	40	.	.	PUNCT
ajst-25612	128	1	in	in	ADP
ajst-25612	128	2	contrast	contrast	NOUN
ajst-25612	128	3	,	,	PUNCT
ajst-25612	128	4	inositol	inositol	NOUN
ajst-25612	128	5	polyphosphate	polyphosphate	NOUN
ajst-25612	128	6	4	4	NUM
ajst-25612	128	7	-	-	PUNCT
ajst-25612	128	8	phosphatase	phosphatase	NOUN
ajst-25612	128	9	type	type	NOUN
ajst-25612	128	10	ii	ii	PROPN
ajst-25612	128	11	(	(	PUNCT
ajst-25612	128	12	inpp4b	inpp4b	PROPN
ajst-25612	128	13	)	)	PUNCT
ajst-25612	128	14	,	,	PUNCT
ajst-25612	128	15	a	a	DET
ajst-25612	128	16	negative	negative	ADJ
ajst-25612	128	17	regulator	regulator	NOUN
ajst-25612	128	18	,	,	PUNCT
ajst-25612	128	19	inhibits	inhibit	VERB
ajst-25612	128	20	tumor	tumor	NOUN
ajst-25612	128	21	cell	cell	NOUN
ajst-25612	128	22	proliferation	proliferation	NOUN
ajst-25612	128	23	and	and	CCONJ
ajst-25612	128	24	overcomes	overcome	VERB
ajst-25612	128	25	immune	immune	ADJ
ajst-25612	128	26	escape	escape	NOUN
ajst-25612	128	27	in	in	ADP
ajst-25612	128	28	gliomas	glioma	NOUN
ajst-25612	128	29	by	by	ADP
ajst-25612	128	30	inhibiting	inhibit	VERB
ajst-25612	128	31	this	this	DET
ajst-25612	128	32	pathway[24	pathway[24	NOUN
ajst-25612	128	33	]	]	PUNCT
ajst-25612	128	34	.	.	PUNCT
ajst-25612	129	1	the	the	DET
ajst-25612	129	2	immune	immune	ADJ
ajst-25612	129	3	checkpoint	checkpoint	NOUN
ajst-25612	129	4	cd276	cd276	NOUN
ajst-25612	129	5	interacts	interact	VERB
ajst-25612	129	6	with	with	ADP
ajst-25612	129	7	the	the	DET
ajst-25612	129	8	pi3k	pi3k	PROPN
ajst-25612	129	9	/	/	SYM
ajst-25612	129	10	akt	akt	PROPN
ajst-25612	129	11	signaling	signal	VERB
ajst-25612	129	12	pathway	pathway	NOUN
ajst-25612	129	13	,	,	PUNCT
ajst-25612	129	14	affecting	affect	VERB
ajst-25612	129	15	tumor	tumor	NOUN
ajst-25612	129	16	energy	energy	NOUN
ajst-25612	129	17	metabolism	metabolism	NOUN
ajst-25612	129	18	,	,	PUNCT
ajst-25612	129	19	suppressing	suppress	VERB
ajst-25612	129	20	immune	immune	ADJ
ajst-25612	129	21	responses	response	NOUN
ajst-25612	129	22	,	,	PUNCT
ajst-25612	129	23	promoting	promote	VERB
ajst-25612	129	24	tumor	tumor	NOUN
ajst-25612	129	25	angiogenesis	angiogenesis	NOUN
ajst-25612	129	26	,	,	PUNCT
ajst-25612	129	27	and	and	CCONJ
ajst-25612	129	28	accelerating	accelerate	VERB
ajst-25612	129	29	immune	immune	ADJ
ajst-25612	129	30	escape	escape	NOUN
ajst-25612	129	31	and	and	CCONJ
ajst-25612	129	32	metastatic	metastatic	ADJ
ajst-25612	129	33	processes[25	processes[25	NOUN
ajst-25612	129	34	]	]	PUNCT
ajst-25612	129	35	.	.	PUNCT
ajst-25612	130	1	the	the	DET
ajst-25612	130	2	study	study	NOUN
ajst-25612	130	3	demonstrated	demonstrate	VERB
ajst-25612	130	4	that	that	SCONJ
ajst-25612	130	5	the	the	DET
ajst-25612	130	6	pi3k	pi3k	PROPN
ajst-25612	130	7	/	/	SYM
ajst-25612	130	8	akt	akt	PROPN
ajst-25612	130	9	signaling	signal	VERB
ajst-25612	130	10	pathway	pathway	NOUN
ajst-25612	130	11	interacts	interact	VERB
ajst-25612	130	12	with	with	ADP
ajst-25612	130	13	tumor	tumor	NOUN
ajst-25612	130	14	energy	energy	NOUN
ajst-25612	130	15	metabolism	metabolism	NOUN
ajst-25612	130	16	,	,	PUNCT
ajst-25612	130	17	inhibiting	inhibit	VERB
ajst-25612	130	18	immune	immune	ADJ
ajst-25612	130	19	responses	response	NOUN
ajst-25612	130	20	,	,	PUNCT
ajst-25612	130	21	promoting	promote	VERB
ajst-25612	130	22	tumor	tumor	NOUN
ajst-25612	130	23	angiogenesis	angiogenesis	NOUN
ajst-25612	130	24	,	,	PUNCT
ajst-25612	130	25	and	and	CCONJ
ajst-25612	130	26	accelerating	accelerate	VERB
ajst-25612	130	27	immune	immune	ADJ
ajst-25612	130	28	escape	escape	NOUN
ajst-25612	130	29	and	and	CCONJ
ajst-25612	130	30	metastasis	metastasis	NOUN
ajst-25612	130	31	.	.	PUNCT
ajst-25612	131	1	a	a	DET
ajst-25612	131	2	number	number	NOUN
ajst-25612	131	3	of	of	ADP
ajst-25612	131	4	studies	study	NOUN
ajst-25612	131	5	have	have	AUX
ajst-25612	131	6	demonstrated	demonstrate	VERB
ajst-25612	131	7	that	that	SCONJ
ajst-25612	131	8	abnormalities	abnormality	NOUN
ajst-25612	131	9	in	in	ADP
ajst-25612	131	10	this	this	DET
ajst-25612	131	11	pathway	pathway	NOUN
ajst-25612	131	12	are	be	AUX
ajst-25612	131	13	prevalent	prevalent	ADJ
ajst-25612	131	14	in	in	ADP
ajst-25612	131	15	a	a	DET
ajst-25612	131	16	wide	wide	ADJ
ajst-25612	131	17	range	range	NOUN
ajst-25612	131	18	of	of	ADP
ajst-25612	131	19	malignant	malignant	ADJ
ajst-25612	131	20	tumors	tumor	NOUN
ajst-25612	131	21	.	.	PUNCT
ajst-25612	132	1	akt	akt	PROPN
ajst-25612	132	2	,	,	PUNCT
ajst-25612	132	3	as	as	ADP
ajst-25612	132	4	a	a	DET
ajst-25612	132	5	key	key	ADJ
ajst-25612	132	6	molecular	molecular	ADJ
ajst-25612	132	7	switch	switch	NOUN
ajst-25612	132	8	regulating	regulate	VERB
ajst-25612	132	9	cell	cell	NOUN
ajst-25612	132	10	proliferation	proliferation	NOUN
ajst-25612	132	11	,	,	PUNCT
ajst-25612	132	12	cycling	cycling	NOUN
ajst-25612	132	13	,	,	PUNCT
ajst-25612	132	14	survival	survival	NOUN
ajst-25612	132	15	,	,	PUNCT
ajst-25612	132	16	migration	migration	NOUN
ajst-25612	132	17	,	,	PUNCT
ajst-25612	132	18	and	and	CCONJ
ajst-25612	132	19	neovascularization	neovascularization	NOUN
ajst-25612	132	20	,	,	PUNCT
ajst-25612	132	21	is	be	AUX
ajst-25612	132	22	central	central	ADJ
ajst-25612	132	23	to	to	ADP
ajst-25612	132	24	the	the	DET
ajst-25612	132	25	integration	integration	NOUN
ajst-25612	132	26	of	of	ADP
ajst-25612	132	27	oncogenic	oncogenic	ADJ
ajst-25612	132	28	signals	signal	NOUN
ajst-25612	132	29	and	and	CCONJ
ajst-25612	132	30	is	be	AUX
ajst-25612	132	31	an	an	DET
ajst-25612	132	32	important	important	ADJ
ajst-25612	132	33	target	target	NOUN
ajst-25612	132	34	for	for	ADP
ajst-25612	132	35	cancer	cancer	NOUN
ajst-25612	132	36	therapy	therapy	NOUN
ajst-25612	132	37	.	.	PUNCT
ajst-25612	133	1	consequently	consequently	ADV
ajst-25612	133	2	,	,	PUNCT
ajst-25612	133	3	intervention	intervention	NOUN
ajst-25612	133	4	strategies	strategy	NOUN
ajst-25612	133	5	targeting	target	VERB
ajst-25612	133	6	this	this	DET
ajst-25612	133	7	pathway	pathway	NOUN
ajst-25612	133	8	are	be	AUX
ajst-25612	133	9	expected	expect	VERB
ajst-25612	133	10	to	to	PART
ajst-25612	133	11	develop	develop	VERB
ajst-25612	133	12	more	more	ADV
ajst-25612	133	13	precise	precise	ADJ
ajst-25612	133	14	anti	anti	ADJ
ajst-25612	133	15	-	-	ADJ
ajst-25612	133	16	cancer	cancer	ADJ
ajst-25612	133	17	therapies[26	therapies[26	NOUN
ajst-25612	133	18	]	]	PUNCT
ajst-25612	133	19	.	.	PUNCT
ajst-25612	134	1	activation	activation	NOUN
ajst-25612	134	2	of	of	ADP
ajst-25612	134	3	the	the	DET
ajst-25612	134	4	pi3k	pi3k	PROPN
ajst-25612	134	5	/	/	SYM
ajst-25612	134	6	akt	akt	PROPN
ajst-25612	134	7	pathway	pathway	NOUN
ajst-25612	134	8	can	can	AUX
ajst-25612	134	9	modulate	modulate	VERB
ajst-25612	134	10	the	the	DET
ajst-25612	134	11	immune	immune	ADJ
ajst-25612	134	12	escape	escape	NOUN
ajst-25612	134	13	mechanism	mechanism	NOUN
ajst-25612	134	14	of	of	ADP
ajst-25612	134	15	tumor	tumor	NOUN
ajst-25612	134	16	cells	cell	NOUN
ajst-25612	134	17	.	.	PUNCT
ajst-25612	135	1	on	on	ADP
ajst-25612	135	2	the	the	DET
ajst-25612	135	3	one	one	NUM
ajst-25612	135	4	hand	hand	NOUN
ajst-25612	135	5	,	,	PUNCT
ajst-25612	135	6	akt	akt	PROPN
ajst-25612	135	7	-	-	PUNCT
ajst-25612	135	8	mediated	mediate	VERB
ajst-25612	135	9	signaling	signaling	NOUN
ajst-25612	135	10	can	can	AUX
ajst-25612	135	11	affect	affect	VERB
ajst-25612	135	12	the	the	DET
ajst-25612	135	13	antigenicity	antigenicity	NOUN
ajst-25612	135	14	of	of	ADP
ajst-25612	135	15	tumor	tumor	NOUN
ajst-25612	135	16	cells	cell	NOUN
ajst-25612	135	17	,	,	PUNCT
ajst-25612	135	18	resulting	result	VERB
ajst-25612	135	19	in	in	ADP
ajst-25612	135	20	the	the	DET
ajst-25612	135	21	inefficient	inefficient	ADJ
ajst-25612	135	22	expression	expression	NOUN
ajst-25612	135	23	of	of	ADP
ajst-25612	135	24	mutant	mutant	ADJ
ajst-25612	135	25	antigens	antigen	NOUN
ajst-25612	135	26	that	that	PRON
ajst-25612	135	27	would	would	AUX
ajst-25612	135	28	otherwise	otherwise	ADV
ajst-25612	135	29	be	be	AUX
ajst-25612	135	30	recognized	recognize	VERB
ajst-25612	135	31	by	by	ADP
ajst-25612	135	32	the	the	DET
ajst-25612	135	33	immune	immune	ADJ
ajst-25612	135	34	system	system	NOUN
ajst-25612	135	35	.	.	PUNCT
ajst-25612	136	1	conversely	conversely	ADV
ajst-25612	136	2	,	,	PUNCT
ajst-25612	136	3	akt	akt	PROPN
ajst-25612	136	4	can	can	AUX
ajst-25612	136	5	also	also	ADV
ajst-25612	136	6	affect	affect	VERB
ajst-25612	136	7	the	the	DET
ajst-25612	136	8	expression	expression	NOUN
ajst-25612	136	9	of	of	ADP
ajst-25612	136	10	immunosuppressive	immunosuppressive	ADJ
ajst-25612	136	11	molecules	molecule	NOUN
ajst-25612	136	12	such	such	ADJ
ajst-25612	136	13	as	as	ADP
ajst-25612	136	14	pd	pd	NOUN
ajst-25612	136	15	-	-	PROPN
ajst-25612	136	16	l1	l1	PROPN
ajst-25612	136	17	.	.	PUNCT
ajst-25612	137	1	by	by	ADP
ajst-25612	137	2	upregulating	upregulate	VERB
ajst-25612	137	3	the	the	DET
ajst-25612	137	4	binding	binding	NOUN
ajst-25612	137	5	of	of	ADP
ajst-25612	137	6	these	these	DET
ajst-25612	137	7	ligands	ligand	NOUN
ajst-25612	137	8	to	to	ADP
ajst-25612	137	9	the	the	DET
ajst-25612	137	10	pd-1	pd-1	ADJ
ajst-25612	137	11	receptor	receptor	NOUN
ajst-25612	137	12	on	on	ADP
ajst-25612	137	13	t	t	NOUN
ajst-25612	137	14	cells	cell	NOUN
ajst-25612	137	15	,	,	PUNCT
ajst-25612	137	16	akt	akt	PROPN
ajst-25612	137	17	can	can	AUX
ajst-25612	137	18	achieve	achieve	VERB
ajst-25612	137	19	the	the	DET
ajst-25612	137	20	suppression	suppression	NOUN
ajst-25612	137	21	of	of	ADP
ajst-25612	137	22	the	the	DET
ajst-25612	137	23	immune	immune	ADJ
ajst-25612	137	24	response	response	NOUN
ajst-25612	137	25	of	of	ADP
ajst-25612	137	26	t	t	NOUN
ajst-25612	137	27	cells	cell	NOUN
ajst-25612	137	28	and	and	CCONJ
ajst-25612	137	29	further	far	ADV
ajst-25612	137	30	promote	promote	VERB
ajst-25612	137	31	the	the	DET
ajst-25612	137	32	immune	immune	ADJ
ajst-25612	137	33	escape	escape	NOUN
ajst-25612	137	34	of	of	ADP
ajst-25612	137	35	tumor	tumor	NOUN
ajst-25612	137	36	cells	cell	NOUN
ajst-25612	137	37	.	.	PUNCT
ajst-25612	138	1	6	6	NUM
ajst-25612	138	2	.	.	X
ajst-25612	138	3	conclusion	conclusion	NOUN
ajst-25612	138	4	this	this	DET
ajst-25612	138	5	review	review	NOUN
ajst-25612	138	6	provides	provide	VERB
ajst-25612	138	7	an	an	DET
ajst-25612	138	8	in	in	ADP
ajst-25612	138	9	-	-	PUNCT
ajst-25612	138	10	depth	depth	NOUN
ajst-25612	138	11	analysis	analysis	NOUN
ajst-25612	138	12	of	of	ADP
ajst-25612	138	13	the	the	DET
ajst-25612	138	14	mechanisms	mechanism	NOUN
ajst-25612	138	15	by	by	ADP
ajst-25612	138	16	which	which	PRON
ajst-25612	138	17	the	the	DET
ajst-25612	138	18	pi3k	pi3k	PROPN
ajst-25612	138	19	/	/	SYM
ajst-25612	138	20	akt	akt	PROPN
ajst-25612	138	21	signaling	signal	VERB
ajst-25612	138	22	pathway	pathway	NOUN
ajst-25612	138	23	promotes	promote	VERB
ajst-25612	138	24	immune	immune	ADJ
ajst-25612	138	25	escape	escape	NOUN
ajst-25612	138	26	in	in	ADP
ajst-25612	138	27	a	a	DET
ajst-25612	138	28	variety	variety	NOUN
ajst-25612	138	29	of	of	ADP
ajst-25612	138	30	cancer	cancer	NOUN
ajst-25612	138	31	types	type	NOUN
ajst-25612	138	32	.	.	PUNCT
ajst-25612	139	1	it	it	PRON
ajst-25612	139	2	reveals	reveal	VERB
ajst-25612	139	3	that	that	SCONJ
ajst-25612	139	4	the	the	DET
ajst-25612	139	5	pathway	pathway	NOUN
ajst-25612	139	6	helps	help	VERB
ajst-25612	139	7	cancer	cancer	NOUN
ajst-25612	139	8	cells	cell	NOUN
ajst-25612	139	9	evade	evade	VERB
ajst-25612	139	10	host	host	NOUN
ajst-25612	139	11	immune	immune	ADJ
ajst-25612	139	12	surveillance	surveillance	NOUN
ajst-25612	139	13	by	by	ADP
ajst-25612	139	14	inhibiting	inhibit	VERB
ajst-25612	139	15	apoptosis	apoptosis	NOUN
ajst-25612	139	16	,	,	PUNCT
ajst-25612	139	17	decreasing	decrease	VERB
ajst-25612	139	18	tcell	tcell	NOUN
ajst-25612	139	19	activation	activation	NOUN
ajst-25612	139	20	,	,	PUNCT
ajst-25612	139	21	modulating	modulate	VERB
ajst-25612	139	22	immune	immune	ADJ
ajst-25612	139	23	cell	cell	NOUN
ajst-25612	139	24	function	function	NOUN
ajst-25612	139	25	,	,	PUNCT
ajst-25612	139	26	and	and	CCONJ
ajst-25612	139	27	upregulating	upregulating	ADJ
ajst-25612	139	28	immune	immune	ADJ
ajst-25612	139	29	-	-	PUNCT
ajst-25612	139	30	suppressive	suppressive	NOUN
ajst-25612	139	31	molecules	molecule	NOUN
ajst-25612	139	32	such	such	ADJ
ajst-25612	139	33	as	as	ADP
ajst-25612	139	34	pd	pd	NOUN
ajst-25612	139	35	-	-	PROPN
ajst-25612	139	36	l1	l1	PROPN
ajst-25612	139	37	expression	expression	NOUN
ajst-25612	139	38	.	.	PUNCT
ajst-25612	140	1	studies	study	NOUN
ajst-25612	140	2	have	have	AUX
ajst-25612	140	3	demonstrated	demonstrate	VERB
ajst-25612	140	4	that	that	SCONJ
ajst-25612	140	5	intervention	intervention	NOUN
ajst-25612	140	6	strategies	strategy	NOUN
ajst-25612	140	7	targeting	target	VERB
ajst-25612	140	8	this	this	DET
ajst-25612	140	9	pathway	pathway	NOUN
ajst-25612	140	10	effectively	effectively	ADV
ajst-25612	140	11	inhibits	inhibit	VERB
ajst-25612	140	12	biomarkers	biomarker	NOUN
ajst-25612	140	13	related	relate	VERB
ajst-25612	140	14	to	to	ADP
ajst-25612	140	15	immune	immune	ADJ
ajst-25612	140	16	escape	escape	NOUN
ajst-25612	140	17	,	,	PUNCT
ajst-25612	140	18	suggesting	suggest	VERB
ajst-25612	140	19	that	that	SCONJ
ajst-25612	140	20	our	our	PRON
ajst-25612	140	21	pathway	pathway	NOUN
ajst-25612	140	22	is	be	AUX
ajst-25612	140	23	an	an	DET
ajst-25612	140	24	important	important	ADJ
ajst-25612	140	25	target	target	NOUN
ajst-25612	140	26	for	for	ADP
ajst-25612	140	27	immunotherapy	immunotherapy	NOUN
ajst-25612	140	28	.	.	PUNCT
ajst-25612	141	1	furthermore	furthermore	ADV
ajst-25612	141	2	,	,	PUNCT
ajst-25612	141	3	abnormalities	abnormality	NOUN
ajst-25612	141	4	in	in	ADP
ajst-25612	141	5	the	the	DET
ajst-25612	141	6	pi3k	pi3k	PROPN
ajst-25612	141	7	/	/	SYM
ajst-25612	141	8	akt	akt	PROPN
ajst-25612	141	9	pathway	pathway	NOUN
ajst-25612	141	10	were	be	AUX
ajst-25612	141	11	closely	closely	ADV
ajst-25612	141	12	associated	associate	VERB
ajst-25612	141	13	with	with	ADP
ajst-25612	141	14	immune	immune	ADJ
ajst-25612	141	15	cell	cell	NOUN
ajst-25612	141	16	infiltration	infiltration	NOUN
ajst-25612	141	17	and	and	CCONJ
ajst-25612	141	18	treatment	treatment	NOUN
ajst-25612	141	19	response	response	NOUN
ajst-25612	141	20	in	in	ADP
ajst-25612	141	21	gastric	gastric	ADJ
ajst-25612	141	22	adenocarcinoma	adenocarcinoma	NOUN
ajst-25612	141	23	,	,	PUNCT
ajst-25612	141	24	ovarian	ovarian	ADJ
ajst-25612	141	25	cancer	cancer	NOUN
ajst-25612	141	26	,	,	PUNCT
ajst-25612	141	27	and	and	CCONJ
ajst-25612	141	28	endometrial	endometrial	ADJ
ajst-25612	141	29	cancer	cancer	NOUN
ajst-25612	141	30	,	,	PUNCT
ajst-25612	141	31	emphasizing	emphasize	VERB
ajst-25612	141	32	its	its	PRON
ajst-25612	141	33	value	value	NOUN
ajst-25612	141	34	as	as	ADP
ajst-25612	141	35	a	a	DET
ajst-25612	141	36	predictor	predictor	NOUN
ajst-25612	141	37	and	and	CCONJ
ajst-25612	141	38	indicator	indicator	NOUN
ajst-25612	141	39	of	of	ADP
ajst-25612	141	40	therapeutic	therapeutic	ADJ
ajst-25612	141	41	efficacy	efficacy	NOUN
ajst-25612	141	42	assessment	assessment	NOUN
ajst-25612	141	43	.	.	PUNCT
ajst-25612	142	1	however	however	ADV
ajst-25612	142	2	,	,	PUNCT
ajst-25612	142	3	there	there	PRON
ajst-25612	142	4	are	be	VERB
ajst-25612	142	5	several	several	ADJ
ajst-25612	142	6	limitations	limitation	NOUN
ajst-25612	142	7	to	to	ADP
ajst-25612	142	8	the	the	DET
ajst-25612	142	9	current	current	ADJ
ajst-25612	142	10	study	study	NOUN
ajst-25612	142	11	.	.	PUNCT
ajst-25612	143	1	firstly	firstly	ADV
ajst-25612	143	2	,	,	PUNCT
ajst-25612	143	3	although	although	SCONJ
ajst-25612	143	4	the	the	DET
ajst-25612	143	5	pi3k	pi3k	PROPN
ajst-25612	143	6	/	/	SYM
ajst-25612	143	7	akt	akt	PROPN
ajst-25612	143	8	pathway	pathway	NOUN
ajst-25612	143	9	is	be	AUX
ajst-25612	143	10	known	know	VERB
ajst-25612	143	11	to	to	PART
ajst-25612	143	12	play	play	VERB
ajst-25612	143	13	a	a	DET
ajst-25612	143	14	key	key	ADJ
ajst-25612	143	15	role	role	NOUN
ajst-25612	143	16	in	in	ADP
ajst-25612	143	17	a	a	DET
ajst-25612	143	18	variety	variety	NOUN
ajst-25612	143	19	of	of	ADP
ajst-25612	143	20	cancers	cancer	NOUN
ajst-25612	143	21	,	,	PUNCT
ajst-25612	143	22	there	there	PRON
ajst-25612	143	23	may	may	AUX
ajst-25612	143	24	be	be	AUX
ajst-25612	143	25	differences	difference	NOUN
ajst-25612	143	26	in	in	ADP
ajst-25612	143	27	its	its	PRON
ajst-25612	143	28	mechanism	mechanism	NOUN
ajst-25612	143	29	of	of	ADP
ajst-25612	143	30	action	action	NOUN
ajst-25612	143	31	and	and	CCONJ
ajst-25612	143	32	sensitivity	sensitivity	NOUN
ajst-25612	143	33	in	in	ADP
ajst-25612	143	34	each	each	DET
ajst-25612	143	35	cancer	cancer	NOUN
ajst-25612	143	36	type	type	NOUN
ajst-25612	143	37	and	and	CCONJ
ajst-25612	143	38	each	each	DET
ajst-25612	143	39	patient	patient	NOUN
ajst-25612	143	40	's	's	PART
ajst-25612	143	41	molecular	molecular	ADJ
ajst-25612	143	42	subtype	subtype	NOUN
ajst-25612	143	43	.	.	PUNCT
ajst-25612	144	1	this	this	PRON
ajst-25612	144	2	necessitates	necessitate	VERB
ajst-25612	144	3	more	more	ADV
ajst-25612	144	4	precise	precise	ADJ
ajst-25612	144	5	molecular	molecular	ADJ
ajst-25612	144	6	typing	typing	NOUN
ajst-25612	144	7	and	and	CCONJ
ajst-25612	144	8	individualized	individualized	ADJ
ajst-25612	144	9	studies	study	NOUN
ajst-25612	144	10	.	.	PUNCT
ajst-25612	145	1	although	although	SCONJ
ajst-25612	145	2	some	some	DET
ajst-25612	145	3	progress	progress	NOUN
ajst-25612	145	4	has	have	AUX
ajst-25612	145	5	been	be	AUX
ajst-25612	145	6	made	make	VERB
ajst-25612	145	7	in	in	ADP
ajst-25612	145	8	the	the	DET
ajst-25612	145	9	development	development	NOUN
ajst-25612	145	10	of	of	ADP
ajst-25612	145	11	drugs	drug	NOUN
ajst-25612	145	12	targeting	target	VERB
ajst-25612	145	13	this	this	DET
ajst-25612	145	14	pathway	pathway	NOUN
ajst-25612	145	15	,	,	PUNCT
ajst-25612	145	16	the	the	DET
ajst-25612	145	17	challenges	challenge	NOUN
ajst-25612	145	18	of	of	ADP
ajst-25612	145	19	drug	drug	NOUN
ajst-25612	145	20	resistance	resistance	NOUN
ajst-25612	145	21	and	and	CCONJ
ajst-25612	145	22	side	side	NOUN
ajst-25612	145	23	effects	effect	NOUN
ajst-25612	145	24	remain	remain	VERB
ajst-25612	145	25	,	,	PUNCT
ajst-25612	145	26	and	and	CCONJ
ajst-25612	145	27	further	further	ADJ
ajst-25612	145	28	optimization	optimization	NOUN
ajst-25612	145	29	of	of	ADP
ajst-25612	145	30	drug	drug	NOUN
ajst-25612	145	31	design	design	NOUN
ajst-25612	145	32	and	and	CCONJ
ajst-25612	145	33	combination	combination	NOUN
ajst-25612	145	34	therapy	therapy	NOUN
ajst-25612	145	35	strategies	strategy	NOUN
ajst-25612	145	36	is	be	AUX
ajst-25612	145	37	needed	need	VERB
ajst-25612	145	38	.	.	PUNCT
ajst-25612	146	1	furthermore	furthermore	ADV
ajst-25612	146	2	,	,	PUNCT
ajst-25612	146	3	although	although	SCONJ
ajst-25612	146	4	the	the	DET
ajst-25612	146	5	combination	combination	NOUN
ajst-25612	146	6	of	of	ADP
ajst-25612	146	7	bioinformatics	bioinformatics	NOUN
ajst-25612	146	8	and	and	CCONJ
ajst-25612	146	9	clinical	clinical	ADJ
ajst-25612	146	10	data	datum	NOUN
ajst-25612	146	11	has	have	AUX
ajst-25612	146	12	helped	help	VERB
ajst-25612	146	13	to	to	PART
ajst-25612	146	14	identify	identify	VERB
ajst-25612	146	15	the	the	DET
ajst-25612	146	16	link	link	NOUN
ajst-25612	146	17	between	between	ADP
ajst-25612	146	18	therapeutic	therapeutic	ADJ
ajst-25612	146	19	response	response	NOUN
ajst-25612	146	20	and	and	CCONJ
ajst-25612	146	21	the	the	DET
ajst-25612	146	22	status	status	NOUN
ajst-25612	146	23	of	of	ADP
ajst-25612	146	24	this	this	DET
ajst-25612	146	25	pathway	pathway	NOUN
ajst-25612	146	26	,	,	PUNCT
ajst-25612	146	27	more	more	ADJ
ajst-25612	146	28	validation	validation	NOUN
ajst-25612	146	29	of	of	ADP
ajst-25612	146	30	how	how	SCONJ
ajst-25612	146	31	to	to	PART
ajst-25612	146	32	translate	translate	VERB
ajst-25612	146	33	these	these	DET
ajst-25612	146	34	findings	finding	NOUN
ajst-25612	146	35	into	into	ADP
ajst-25612	146	36	effective	effective	ADJ
ajst-25612	146	37	therapeutic	therapeutic	ADJ
ajst-25612	146	38	regimens	regimen	NOUN
ajst-25612	146	39	in	in	ADP
ajst-25612	146	40	clinical	clinical	ADJ
ajst-25612	146	41	practice	practice	NOUN
ajst-25612	146	42	is	be	AUX
ajst-25612	146	43	still	still	ADV
ajst-25612	146	44	needed	need	VERB
ajst-25612	146	45	.	.	PUNCT
ajst-25612	147	1	future	future	ADJ
ajst-25612	147	2	research	research	NOUN
ajst-25612	147	3	should	should	AUX
ajst-25612	147	4	concentrate	concentrate	VERB
ajst-25612	147	5	on	on	ADP
ajst-25612	147	6	several	several	ADJ
ajst-25612	147	7	key	key	ADJ
ajst-25612	147	8	areas	area	NOUN
ajst-25612	147	9	.	.	PUNCT
ajst-25612	148	1	firstly	firstly	ADV
ajst-25612	148	2	,	,	PUNCT
ajst-25612	148	3	there	there	PRON
ajst-25612	148	4	is	be	VERB
ajst-25612	148	5	a	a	DET
ajst-25612	148	6	need	need	NOUN
ajst-25612	148	7	to	to	PART
ajst-25612	148	8	deepen	deepen	VERB
ajst-25612	148	9	the	the	DET
ajst-25612	148	10	understanding	understanding	NOUN
ajst-25612	148	11	of	of	ADP
ajst-25612	148	12	the	the	DET
ajst-25612	148	13	mechanism	mechanism	NOUN
ajst-25612	148	14	of	of	ADP
ajst-25612	148	15	action	action	NOUN
ajst-25612	148	16	of	of	ADP
ajst-25612	148	17	the	the	DET
ajst-25612	148	18	pi3k	pi3k	PROPN
ajst-25612	148	19	/	/	SYM
ajst-25612	148	20	akt	akt	PROPN
ajst-25612	148	21	pathway	pathway	NOUN
ajst-25612	148	22	in	in	ADP
ajst-25612	148	23	different	different	ADJ
ajst-25612	148	24	cancers	cancer	NOUN
ajst-25612	148	25	and	and	CCONJ
ajst-25612	148	26	immune	immune	ADJ
ajst-25612	148	27	microenvironments	microenvironment	NOUN
ajst-25612	148	28	.	.	PUNCT
ajst-25612	149	1	secondly	secondly	ADV
ajst-25612	149	2	,	,	PUNCT
ajst-25612	149	3	there	there	PRON
ajst-25612	149	4	is	be	VERB
ajst-25612	149	5	a	a	DET
ajst-25612	149	6	need	need	NOUN
ajst-25612	149	7	to	to	PART
ajst-25612	149	8	discover	discover	VERB
ajst-25612	149	9	and	and	CCONJ
ajst-25612	149	10	validate	validate	VERB
ajst-25612	149	11	new	new	ADJ
ajst-25612	149	12	targets	target	NOUN
ajst-25612	149	13	and	and	CCONJ
ajst-25612	149	14	small	small	ADJ
ajst-25612	149	15	-	-	PUNCT
ajst-25612	149	16	molecule	molecule	NOUN
ajst-25612	149	17	inhibitors	inhibitor	NOUN
ajst-25612	149	18	against	against	ADP
ajst-25612	149	19	the	the	DET
ajst-25612	149	20	pi3k	pi3k	PROPN
ajst-25612	149	21	/	/	SYM
ajst-25612	149	22	akt	akt	PROPN
ajst-25612	149	23	pathway	pathway	NOUN
ajst-25612	149	24	.	.	PUNCT
ajst-25612	150	1	this	this	PRON
ajst-25612	150	2	can	can	AUX
ajst-25612	150	3	be	be	AUX
ajst-25612	150	4	achieved	achieve	VERB
ajst-25612	150	5	by	by	ADP
ajst-25612	150	6	using	use	VERB
ajst-25612	150	7	high	high	ADJ
ajst-25612	150	8	-	-	PUNCT
ajst-25612	150	9	throughput	throughput	NOUN
ajst-25612	150	10	screening	screening	NOUN
ajst-25612	150	11	technologies	technology	NOUN
ajst-25612	150	12	and	and	CCONJ
ajst-25612	150	13	artificial	artificial	ADJ
ajst-25612	150	14	intelligence	intelligence	NOUN
ajst-25612	150	15	algorithms	algorithm	NOUN
ajst-25612	150	16	.	.	PUNCT
ajst-25612	151	1	thirdly	thirdly	ADV
ajst-25612	151	2	,	,	PUNCT
ajst-25612	151	3	there	there	PRON
ajst-25612	151	4	is	be	VERB
ajst-25612	151	5	a	a	DET
ajst-25612	151	6	need	need	NOUN
ajst-25612	151	7	for	for	ADP
ajst-25612	151	8	more	more	ADJ
ajst-25612	151	9	interdisciplinary	interdisciplinary	ADJ
ajst-25612	151	10	collaborations	collaboration	NOUN
ajst-25612	151	11	.	.	PUNCT
ajst-25612	152	1	collaborations	collaboration	NOUN
ajst-25612	152	2	should	should	AUX
ajst-25612	152	3	be	be	AUX
ajst-25612	152	4	established	establish	VERB
ajst-25612	152	5	to	to	PART
ajst-25612	152	6	combine	combine	VERB
ajst-25612	152	7	genomics	genomics	NOUN
ajst-25612	152	8	,	,	PUNCT
ajst-25612	152	9	proteomics	proteomic	NOUN
ajst-25612	152	10	,	,	PUNCT
ajst-25612	152	11	immunology	immunology	NOUN
ajst-25612	152	12	,	,	PUNCT
ajst-25612	152	13	and	and	CCONJ
ajst-25612	152	14	other	other	ADJ
ajst-25612	152	15	multi	multi	ADJ
ajst-25612	152	16	-	-	ADJ
ajst-25612	152	17	omics	omics	ADJ
ajst-25612	152	18	data	datum	NOUN
ajst-25612	152	19	in	in	ADP
ajst-25612	152	20	order	order	NOUN
ajst-25612	152	21	to	to	PART
ajst-25612	152	22	promote	promote	VERB
ajst-25612	152	23	the	the	DET
ajst-25612	152	24	development	development	NOUN
ajst-25612	152	25	of	of	ADP
ajst-25612	152	26	precision	precision	NOUN
ajst-25612	152	27	medicine	medicine	NOUN
ajst-25612	152	28	and	and	CCONJ
ajst-25612	152	29	realize	realize	VERB
ajst-25612	152	30	patientspecific	patientspecific	ADJ
ajst-25612	152	31	therapeutic	therapeutic	ADJ
ajst-25612	152	32	strategies	strategy	NOUN
ajst-25612	152	33	.	.	PUNCT
ajst-25612	153	1	furthermore	furthermore	ADV
ajst-25612	153	2	,	,	PUNCT
ajst-25612	153	3	the	the	DET
ajst-25612	153	4	design	design	NOUN
ajst-25612	153	5	and	and	CCONJ
ajst-25612	153	6	implementation	implementation	NOUN
ajst-25612	153	7	of	of	ADP
ajst-25612	153	8	clinical	clinical	ADJ
ajst-25612	153	9	trials	trial	NOUN
ajst-25612	153	10	should	should	AUX
ajst-25612	153	11	be	be	AUX
ajst-25612	153	12	strengthened	strengthen	VERB
ajst-25612	153	13	in	in	ADP
ajst-25612	153	14	174	174	NUM
ajst-25612	153	15	order	order	NOUN
ajst-25612	153	16	to	to	PART
ajst-25612	153	17	evaluate	evaluate	VERB
ajst-25612	153	18	the	the	DET
ajst-25612	153	19	safety	safety	NOUN
ajst-25612	153	20	and	and	CCONJ
ajst-25612	153	21	efficacy	efficacy	NOUN
ajst-25612	153	22	of	of	ADP
ajst-25612	153	23	pi3k	pi3k	PROPN
ajst-25612	153	24	/	/	SYM
ajst-25612	153	25	akt	akt	PROPN
ajst-25612	153	26	inhibitors	inhibitor	NOUN
ajst-25612	153	27	in	in	ADP
ajst-25612	153	28	combination	combination	NOUN
ajst-25612	153	29	with	with	ADP
ajst-25612	153	30	other	other	ADJ
ajst-25612	153	31	immunotherapies	immunotherapy	NOUN
ajst-25612	153	32	or	or	CCONJ
ajst-25612	153	33	targeted	target	VERB
ajst-25612	153	34	therapies	therapy	NOUN
ajst-25612	153	35	.	.	PUNCT
ajst-25612	154	1	through	through	ADP
ajst-25612	154	2	efforts	effort	NOUN
ajst-25612	154	3	,	,	PUNCT
ajst-25612	154	4	more	more	ADV
ajst-25612	154	5	innovative	innovative	ADJ
ajst-25612	154	6	treatment	treatment	NOUN
ajst-25612	154	7	opportunities	opportunity	NOUN
ajst-25612	154	8	will	will	AUX
ajst-25612	154	9	be	be	AUX
ajst-25612	154	10	opened	open	VERB
ajst-25612	154	11	up	up	ADP
ajst-25612	154	12	in	in	ADP
ajst-25612	154	13	the	the	DET
ajst-25612	154	14	future	future	ADJ
ajst-25612	154	15	studies	study	NOUN
ajst-25612	154	16	on	on	ADP
ajst-25612	154	17	pi3k	pi3k	PROPN
ajst-25612	154	18	/	/	SYM
ajst-25612	154	19	akt	akt	PROPN
ajst-25612	154	20	pathway	pathway	NOUN
ajst-25612	154	21	and	and	CCONJ
ajst-25612	154	22	immune	immune	ADJ
ajst-25612	154	23	escape	escape	NOUN
ajst-25612	154	24	,	,	PUNCT
ajst-25612	154	25	which	which	PRON
ajst-25612	154	26	will	will	AUX
ajst-25612	154	27	significantly	significantly	ADV
ajst-25612	154	28	improve	improve	VERB
ajst-25612	154	29	the	the	DET
ajst-25612	154	30	accuracy	accuracy	NOUN
ajst-25612	154	31	and	and	CCONJ
ajst-25612	154	32	success	success	NOUN
ajst-25612	154	33	rate	rate	NOUN
ajst-25612	154	34	of	of	ADP
ajst-25612	154	35	cancer	cancer	NOUN
ajst-25612	154	36	treatment	treatment	NOUN
ajst-25612	154	37	.	.	PUNCT
ajst-25612	155	1	references	reference	NOUN
ajst-25612	155	2	[	[	X
ajst-25612	155	3	1	1	X
ajst-25612	155	4	]	]	X
ajst-25612	155	5	liu	liu	PROPN
ajst-25612	155	6	h.	h.	PROPN
ajst-25612	155	7	et	et	PROPN
ajst-25612	155	8	al	al	PROPN
ajst-25612	155	9	.	.	PROPN
ajst-25612	155	10	necroptosis	necroptosis	NOUN
ajst-25612	155	11	-	-	PUNCT
ajst-25612	155	12	related	relate	VERB
ajst-25612	155	13	prognostic	prognostic	ADJ
ajst-25612	155	14	model	model	NOUN
ajst-25612	155	15	for	for	ADP
ajst-25612	155	16	pancreatic	pancreatic	ADJ
ajst-25612	155	17	carcinoma	carcinoma	NOUN
ajst-25612	155	18	reveals	reveal	VERB
ajst-25612	155	19	its	its	PRON
ajst-25612	155	20	invasion	invasion	NOUN
ajst-25612	155	21	and	and	CCONJ
ajst-25612	155	22	metastasis	metastasis	NOUN
ajst-25612	155	23	potential	potential	NOUN
ajst-25612	155	24	through	through	ADP
ajst-25612	155	25	hybrid	hybrid	ADJ
ajst-25612	155	26	emt	emt	NOUN
ajst-25612	155	27	and	and	CCONJ
ajst-25612	155	28	immune	immune	ADJ
ajst-25612	155	29	escape[j	escape[j	PROPN
ajst-25612	155	30	]	]	PUNCT
ajst-25612	155	31	.	.	PUNCT
ajst-25612	156	1	biomedicines	biomedicine	NOUN
ajst-25612	156	2	,	,	PUNCT
ajst-25612	156	3	2023	2023	NUM
ajst-25612	156	4	,	,	PUNCT
ajst-25612	156	5	11(6	11(6	NUM
ajst-25612	156	6	):	):	PUNCT
ajst-25612	156	7	1738	1738	NUM
ajst-25612	156	8	.	.	PUNCT
ajst-25612	157	1	[	[	X
ajst-25612	157	2	2	2	NUM
ajst-25612	157	3	]	]	X
ajst-25612	157	4	sharma	sharma	PROPN
ajst-25612	157	5	v.	v.	ADP
ajst-25612	157	6	et	et	PROPN
ajst-25612	157	7	al	al	PROPN
ajst-25612	157	8	.	.	PUNCT
ajst-25612	158	1	recent	recent	ADJ
ajst-25612	158	2	nanotechnological	nanotechnological	ADJ
ajst-25612	158	3	interventions	intervention	NOUN
ajst-25612	158	4	targeting	target	VERB
ajst-25612	158	5	pi3k	pi3k	PROPN
ajst-25612	158	6	/	/	SYM
ajst-25612	158	7	akt	akt	PROPN
ajst-25612	158	8	/	/	SYM
ajst-25612	158	9	mtor	mtor	PROPN
ajst-25612	158	10	pathway	pathway	NOUN
ajst-25612	158	11	:	:	PUNCT
ajst-25612	158	12	a	a	DET
ajst-25612	158	13	focus	focus	NOUN
ajst-25612	158	14	on	on	ADP
ajst-25612	158	15	breast	breast	NOUN
ajst-25612	158	16	cancer[j	cancer[j	NOUN
ajst-25612	158	17	]	]	PUNCT
ajst-25612	158	18	.	.	PUNCT
ajst-25612	159	1	seminars	seminar	NOUN
ajst-25612	159	2	in	in	ADP
ajst-25612	159	3	cancer	cancer	NOUN
ajst-25612	159	4	biology	biology	NOUN
ajst-25612	159	5	,	,	PUNCT
ajst-25612	159	6	2019	2019	NUM
ajst-25612	159	7	,	,	PUNCT
ajst-25612	159	8	59133	59133	NUM
ajst-25612	159	9	-	-	SYM
ajst-25612	159	10	146	146	NUM
ajst-25612	159	11	.	.	PUNCT
ajst-25612	160	1	[	[	X
ajst-25612	160	2	3	3	NUM
ajst-25612	160	3	]	]	PUNCT
ajst-25612	160	4	chai	chai	NOUN
ajst-25612	160	5	c.	c.	PROPN
ajst-25612	160	6	et	et	PROPN
ajst-25612	161	1	al	al	PROPN
ajst-25612	161	2	.	.	PUNCT
ajst-25612	161	3	bcr	bcr	PROPN
ajst-25612	161	4	-	-	PUNCT
ajst-25612	161	5	abl1	abl1	ADV
ajst-25612	161	6	-	-	PUNCT
ajst-25612	161	7	driven	drive	VERB
ajst-25612	161	8	exosome	exosome	NOUN
ajst-25612	161	9	-	-	PUNCT
ajst-25612	161	10	mir130b-3pmediated	mir130b-3pmediate	VERB
ajst-25612	161	11	gap	gap	NOUN
ajst-25612	161	12	-	-	PUNCT
ajst-25612	161	13	junction	junction	NOUN
ajst-25612	161	14	cx43	cx43	PROPN
ajst-25612	161	15	msc	msc	PROPN
ajst-25612	161	16	intercellular	intercellular	ADJ
ajst-25612	161	17	communications	communication	NOUN
ajst-25612	161	18	imply	imply	VERB
ajst-25612	161	19	therapies	therapy	NOUN
ajst-25612	161	20	of	of	ADP
ajst-25612	161	21	leukemic	leukemic	ADJ
ajst-25612	161	22	subclonal	subclonal	ADJ
ajst-25612	161	23	evolution	evolution	NOUN
ajst-25612	162	1	[	[	X
ajst-25612	162	2	j	j	X
ajst-25612	162	3	]	]	X
ajst-25612	162	4	.	.	PUNCT
ajst-25612	162	5	theranostics	theranostic	NOUN
ajst-25612	162	6	,	,	PUNCT
ajst-25612	162	7	2023	2023	NUM
ajst-25612	162	8	,	,	PUNCT
ajst-25612	162	9	13(12	13(12	NUM
ajst-25612	162	10	):	):	PUNCT
ajst-25612	162	11	3943	3943	NUM
ajst-25612	162	12	.	.	PUNCT
ajst-25612	163	1	[	[	X
ajst-25612	163	2	4	4	NUM
ajst-25612	163	3	]	]	PUNCT
ajst-25612	163	4	shen	shen	PROPN
ajst-25612	163	5	h.	h.	PROPN
ajst-25612	163	6	et	et	PROPN
ajst-25612	163	7	al	al	PROPN
ajst-25612	163	8	.	.	PUNCT
ajst-25612	163	9	overcoming	overcome	VERB
ajst-25612	163	10	mtdh	mtdh	NOUN
ajst-25612	163	11	and	and	CCONJ
ajst-25612	163	12	mtdh	mtdh	NOUN
ajst-25612	163	13	-	-	PUNCT
ajst-25612	163	14	snd1	snd1	NOUN
ajst-25612	163	15	complex	complex	NOUN
ajst-25612	163	16	:	:	PUNCT
ajst-25612	163	17	driver	driver	NOUN
ajst-25612	163	18	and	and	CCONJ
ajst-25612	163	19	potential	potential	ADJ
ajst-25612	163	20	therapeutic	therapeutic	ADJ
ajst-25612	163	21	target	target	NOUN
ajst-25612	163	22	of	of	ADP
ajst-25612	163	23	cancer[j	cancer[j	NOUN
ajst-25612	163	24	]	]	PUNCT
ajst-25612	163	25	.	.	PUNCT
ajst-25612	164	1	cancer	cancer	NOUN
ajst-25612	164	2	insight	insight	NOUN
ajst-25612	164	3	,	,	PUNCT
ajst-25612	164	4	2023	2023	NUM
ajst-25612	164	5	,	,	PUNCT
ajst-25612	164	6	3(1	3(1	NUM
ajst-25612	164	7	):	):	PUNCT
ajst-25612	164	8	55	55	NUM
ajst-25612	164	9	-	-	SYM
ajst-25612	164	10	82	82	NUM
ajst-25612	164	11	.	.	PUNCT
ajst-25612	165	1	[	[	X
ajst-25612	165	2	5	5	X
ajst-25612	165	3	]	]	X
ajst-25612	165	4	huang	huang	PROPN
ajst-25612	165	5	xulan	xulan	PROPN
ajst-25612	165	6	et	et	PROPN
ajst-25612	165	7	al	al	PROPN
ajst-25612	165	8	.	.	PROPN
ajst-25612	165	9	progress	progress	NOUN
ajst-25612	165	10	in	in	ADP
ajst-25612	165	11	the	the	DET
ajst-25612	165	12	relationship	relationship	NOUN
ajst-25612	165	13	between	between	ADP
ajst-25612	165	14	pi3k	pi3k	PROPN
ajst-25612	165	15	/	/	SYM
ajst-25612	165	16	akt	akt	PROPN
ajst-25612	165	17	signaling	signal	VERB
ajst-25612	165	18	pathway	pathway	NOUN
ajst-25612	165	19	and	and	CCONJ
ajst-25612	165	20	tumor	tumor	NOUN
ajst-25612	165	21	cell	cell	NOUN
ajst-25612	165	22	apoptosis[j	apoptosis[j	PROPN
ajst-25612	165	23	]	]	PUNCT
ajst-25612	165	24	.	.	PUNCT
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ajst-25612	166	2	,	,	PUNCT
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ajst-25612	166	4	-	-	SYM
ajst-25612	166	5	336	336	NUM
ajst-25612	166	6	.	.	PUNCT
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ajst-25612	167	2	6	6	NUM
ajst-25612	167	3	]	]	X
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ajst-25612	167	8	al	al	PROPN
ajst-25612	167	9	.	.	PUNCT
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ajst-25612	168	2	role	role	NOUN
ajst-25612	168	3	does	do	AUX
ajst-25612	168	4	pdl1	pdl1	NOUN
ajst-25612	168	5	play	play	VERB
ajst-25612	168	6	in	in	ADP
ajst-25612	168	7	emt	emt	PROPN
ajst-25612	168	8	changes	change	NOUN
ajst-25612	168	9	in	in	ADP
ajst-25612	168	10	tumors	tumor	NOUN
ajst-25612	168	11	and	and	CCONJ
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ajst-25612	168	13	?	?	PUNCT
ajst-25612	169	1	[	[	X
ajst-25612	169	2	j	j	X
ajst-25612	169	3	]	]	X
ajst-25612	169	4	.	.	PUNCT
ajst-25612	170	1	frontiers	frontier	NOUN
ajst-25612	170	2	in	in	ADP
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ajst-25612	170	4	,	,	PUNCT
ajst-25612	170	5	2023	2023	NUM
ajst-25612	170	6	,	,	PUNCT
ajst-25612	170	7	14	14	NUM
ajst-25612	170	8	:	:	SYM
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ajst-25612	170	10	.	.	PUNCT
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ajst-25612	171	2	7	7	NUM
ajst-25612	171	3	]	]	X
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ajst-25612	171	6	et	et	PROPN
ajst-25612	171	7	al	al	PROPN
ajst-25612	171	8	.	.	PUNCT
ajst-25612	171	9	fgf19	fgf19	PROPN
ajst-25612	171	10	/	/	SYM
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ajst-25612	171	13	contributes	contribute	VERB
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ajst-25612	171	15	hepatocellular	hepatocellular	ADJ
ajst-25612	171	16	carcinoma	carcinoma	NOUN
ajst-25612	171	17	survival	survival	NOUN
ajst-25612	171	18	and	and	CCONJ
ajst-25612	171	19	immune	immune	ADJ
ajst-25612	171	20	escape	escape	NOUN
ajst-25612	171	21	by	by	ADP
ajst-25612	171	22	regulating	regulate	VERB
ajst-25612	171	23	igf2bp1	igf2bp1	NOUN
ajst-25612	171	24	-	-	PUNCT
ajst-25612	171	25	mediated	mediate	VERB
ajst-25612	171	26	expression	expression	NOUN
ajst-25612	171	27	of	of	ADP
ajst-25612	171	28	pd	pd	PROPN
ajst-25612	171	29	-	-	PUNCT
ajst-25612	171	30	l1[j	l1[j	PROPN
ajst-25612	171	31	]	]	PUNCT
ajst-25612	171	32	.	.	PUNCT
ajst-25612	172	1	biomedicine	biomedicine	PROPN
ajst-25612	172	2	&	&	CCONJ
ajst-25612	172	3	pharmacotherapy	pharmacotherapy	NOUN
ajst-25612	172	4	,	,	PUNCT
ajst-25612	172	5	2024	2024	NUM
ajst-25612	172	6	,	,	PUNCT
ajst-25612	172	7	170	170	NUM
ajst-25612	172	8	:	:	SYM
ajst-25612	172	9	115955	115955	NUM
ajst-25612	172	10	.	.	PUNCT
ajst-25612	173	1	[	[	X
ajst-25612	173	2	8	8	NUM
ajst-25612	173	3	]	]	X
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ajst-25612	173	5	da	da	PROPN
ajst-25612	173	6	.	.	PUNCT
ajst-25612	173	7	et	et	PROPN
ajst-25612	174	1	al	al	PROPN
ajst-25612	174	2	.	.	PROPN
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ajst-25612	174	4	and	and	CCONJ
ajst-25612	174	5	mtor	mtor	PROPN
ajst-25612	174	6	phosphorylation	phosphorylation	NOUN
ajst-25612	174	7	is	be	AUX
ajst-25612	174	8	frequently	frequently	ADV
ajst-25612	174	9	detected	detect	VERB
ajst-25612	174	10	in	in	ADP
ajst-25612	174	11	ovarian	ovarian	ADJ
ajst-25612	174	12	cancer	cancer	NOUN
ajst-25612	174	13	and	and	CCONJ
ajst-25612	174	14	can	can	AUX
ajst-25612	174	15	be	be	AUX
ajst-25612	174	16	targeted	target	VERB
ajst-25612	174	17	to	to	PART
ajst-25612	174	18	disrupt	disrupt	VERB
ajst-25612	174	19	ovarian	ovarian	ADJ
ajst-25612	174	20	tumor	tumor	NOUN
ajst-25612	174	21	cell	cell	NOUN
ajst-25612	174	22	growth[j	growth[j	PROPN
ajst-25612	174	23	]	]	PUNCT
ajst-25612	174	24	.	.	PUNCT
ajst-25612	175	1	oncogene	oncogene	NOUN
ajst-25612	175	2	,	,	PUNCT
ajst-25612	175	3	2004,23:58535857	2004,23:58535857	NOUN
ajst-25612	175	4	.	.	PUNCT
ajst-25612	176	1	[	[	X
ajst-25612	176	2	9	9	NUM
ajst-25612	176	3	]	]	X
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ajst-25612	176	5	-	-	PUNCT
ajst-25612	176	6	eid	eid	PROPN
ajst-25612	176	7	,	,	PUNCT
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ajst-25612	176	9	et	et	PROPN
ajst-25612	176	10	al	al	PROPN
ajst-25612	176	11	.	.	PROPN
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ajst-25612	176	13	inhibition	inhibition	NOUN
ajst-25612	176	14	of	of	ADP
ajst-25612	176	15	regulatory	regulatory	ADJ
ajst-25612	176	16	t	t	NOUN
ajst-25612	176	17	cells	cell	NOUN
ajst-25612	176	18	by	by	ADP
ajst-25612	176	19	targeting	target	VERB
ajst-25612	176	20	the	the	DET
ajst-25612	176	21	pi3k	pi3k	PROPN
ajst-25612	176	22	/	/	SYM
ajst-25612	176	23	akt	akt	PROPN
ajst-25612	176	24	pathway[j	pathway[j	NOUN
ajst-25612	176	25	]	]	PUNCT
ajst-25612	176	26	.	.	PUNCT
ajst-25612	177	1	cancer	cancer	NOUN
ajst-25612	177	2	immunol	immunol	NOUN
ajst-25612	177	3	research	research	NOUN
ajst-25612	177	4	,	,	PUNCT
ajst-25612	177	5	2014,2(11):1080	2014,2(11):1080	NUM
ajst-25612	177	6	-	-	SYM
ajst-25612	177	7	1089	1089	NUM
ajst-25612	177	8	.	.	PUNCT
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ajst-25612	178	2	10	10	NUM
ajst-25612	178	3	]	]	X
ajst-25612	178	4	rui	rui	PROPN
ajst-25612	178	5	z.	z.	PROPN
ajst-25612	178	6	et	et	PROPN
ajst-25612	178	7	al	al	PROPN
ajst-25612	178	8	.	.	PUNCT
ajst-25612	178	9	pd-1	pd-1	ADP
ajst-25612	178	10	/	/	SYM
ajst-25612	178	11	pd	pd	ADJ
ajst-25612	178	12	-	-	PUNCT
ajst-25612	178	13	l1	l1	PROPN
ajst-25612	178	14	blockade	blockade	NOUN
ajst-25612	178	15	rescue	rescue	NOUN
ajst-25612	178	16	exhausted	exhaust	VERB
ajst-25612	178	17	cd8	cd8	PROPN
ajst-25612	178	18	+	+	PROPN
ajst-25612	178	19	t	t	NOUN
ajst-25612	178	20	cells	cell	NOUN
ajst-25612	178	21	in	in	ADP
ajst-25612	178	22	gastrointestinal	gastrointestinal	ADJ
ajst-25612	178	23	stromal	stromal	ADJ
ajst-25612	178	24	tumours	tumour	NOUN
ajst-25612	178	25	via	via	ADP
ajst-25612	178	26	the	the	DET
ajst-25612	178	27	pi3k/	pi3k/	NOUN
ajst-25612	178	28	akt/	akt/	PROPN
ajst-25612	178	29	m	m	VERB
ajst-25612	178	30	tor	tor	NOUN
ajst-25612	178	31	signalling	signal	VERB
ajst-25612	178	32	pathway[j	pathway[j	NOUN
ajst-25612	178	33	]	]	PUNCT
ajst-25612	178	34	.	.	PUNCT
ajst-25612	179	1	cell	cell	NOUN
ajst-25612	179	2	proliferation	proliferation	NOUN
ajst-25612	179	3	,	,	PUNCT
ajst-25612	179	4	2019	2019	NUM
ajst-25612	179	5	,	,	PUNCT
ajst-25612	179	6	52	52	NUM
ajst-25612	179	7	(	(	PUNCT
ajst-25612	179	8	3	3	NUM
ajst-25612	179	9	):	):	PUNCT
ajst-25612	179	10	e	e	NOUN
ajst-25612	179	11	12571	12571	NUM
ajst-25612	179	12	.	.	PUNCT
ajst-25612	180	1	[	[	X
ajst-25612	180	2	11	11	NUM
ajst-25612	180	3	]	]	PUNCT
ajst-25612	180	4	hussain	hussain	PROPN
ajst-25612	180	5	s.	s.	PROPN
ajst-25612	180	6	et	et	PROPN
ajst-25612	180	7	al	al	PROPN
ajst-25612	180	8	.	.	PUNCT
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ajst-25612	180	10	of	of	ADP
ajst-25612	180	11	cancer	cancer	NOUN
ajst-25612	180	12	progression	progression	NOUN
ajst-25612	180	13	by	by	ADP
ajst-25612	180	14	ck2	ck2	PROPN
ajst-25612	180	15	:	:	PUNCT
ajst-25612	180	16	an	an	DET
ajst-25612	180	17	emerging	emerge	VERB
ajst-25612	180	18	therapeutic	therapeutic	ADJ
ajst-25612	180	19	target[j	target[j	NOUN
ajst-25612	180	20	]	]	PUNCT
ajst-25612	180	21	.	.	PUNCT
ajst-25612	181	1	medical	medical	ADJ
ajst-25612	181	2	oncology	oncology	NOUN
ajst-25612	181	3	,	,	PUNCT
ajst-25612	181	4	2024	2024	NUM
ajst-25612	181	5	,	,	PUNCT
ajst-25612	181	6	41(5	41(5	NUM
ajst-25612	181	7	):	):	PUNCT
ajst-25612	181	8	94	94	NUM
ajst-25612	181	9	.	.	PUNCT
ajst-25612	182	1	[	[	X
ajst-25612	182	2	12	12	NUM
ajst-25612	182	3	]	]	X
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ajst-25612	182	5	,	,	PUNCT
ajst-25612	182	6	k.	k.	PROPN
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ajst-25612	182	8	et	et	PROPN
ajst-25612	182	9	al	al	PROPN
ajst-25612	182	10	.	.	PROPN
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ajst-25612	182	12	stress	stress	NOUN
ajst-25612	182	13	in	in	ADP
ajst-25612	182	14	cancer	cancer	NOUN
ajst-25612	182	15	cells	cell	NOUN
ajst-25612	182	16	induces	induce	VERB
ajst-25612	182	17	immune	immune	ADJ
ajst-25612	182	18	escape	escape	NOUN
ajst-25612	182	19	through	through	ADP
ajst-25612	182	20	a	a	DET
ajst-25612	182	21	pi3k	pi3k	NOUN
ajst-25612	182	22	-	-	PUNCT
ajst-25612	182	23	dependent	dependent	ADJ
ajst-25612	182	24	blockade	blockade	NOUN
ajst-25612	182	25	of	of	ADP
ajst-25612	182	26	ifnγ	ifnγ	NOUN
ajst-25612	182	27	receptor	receptor	NOUN
ajst-25612	182	28	signaling[j	signaling[j	PROPN
ajst-25612	182	29	]	]	PUNCT
ajst-25612	182	30	.	.	PUNCT
ajst-25612	183	1	journal	journal	PROPN
ajst-25612	183	2	for	for	ADP
ajst-25612	183	3	immunotherapy	immunotherapy	NOUN
ajst-25612	183	4	of	of	ADP
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ajst-25612	183	6	,	,	PUNCT
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ajst-25612	183	8	-	-	SYM
ajst-25612	183	9	12	12	NUM
ajst-25612	183	10	.	.	PUNCT
ajst-25612	184	1	[	[	X
ajst-25612	184	2	13	13	NUM
ajst-25612	184	3	]	]	X
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ajst-25612	184	5	,	,	PUNCT
ajst-25612	184	6	e.h	e.h	PROPN
ajst-25612	184	7	.	.	PROPN
ajst-25612	184	8	,	,	PUNCT
ajst-25612	184	9	suresh	suresh	PROPN
ajst-25612	184	10	,	,	PUNCT
ajst-25612	184	11	m.	m.	NOUN
ajst-25612	184	12	role	role	NOUN
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ajst-25612	184	14	pi3k	pi3k	PROPN
ajst-25612	184	15	/	/	SYM
ajst-25612	184	16	akt	akt	PROPN
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ajst-25612	184	18	in	in	ADP
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ajst-25612	184	21	t	t	PROPN
ajst-25612	184	22	cell	cell	NOUN
ajst-25612	184	23	differentiation[j	differentiation[j	PROPN
ajst-25612	184	24	]	]	PUNCT
ajst-25612	184	25	.	.	PUNCT
ajst-25612	185	1	frontiers	frontier	NOUN
ajst-25612	185	2	in	in	ADP
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ajst-25612	185	4	,	,	PUNCT
ajst-25612	185	5	2013	2013	NUM
ajst-25612	185	6	,	,	PUNCT
ajst-25612	185	7	420	420	NUM
ajst-25612	185	8	.	.	PUNCT
ajst-25612	186	1	[	[	X
ajst-25612	186	2	14	14	NUM
ajst-25612	186	3	]	]	SYM
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ajst-25612	186	5	,	,	PUNCT
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ajst-25612	186	8	et	et	PROPN
ajst-25612	186	9	al	al	PROPN
ajst-25612	186	10	.	.	PROPN
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ajst-25612	186	12	of	of	ADP
ajst-25612	186	13	akt	akt	PROPN
ajst-25612	186	14	as	as	ADP
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ajst-25612	186	20	evasion[j	evasion[j	NOUN
ajst-25612	186	21	]	]	PUNCT
ajst-25612	186	22	.	.	PUNCT
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ajst-25612	187	2	therapy	therapy	NOUN
ajst-25612	187	3	,	,	PUNCT
ajst-25612	187	4	2009,17(3):439	2009,17(3):439	NOUN
ajst-25612	187	5	-	-	SYM
ajst-25612	187	6	447	447	NUM
ajst-25612	187	7	.	.	PUNCT
ajst-25612	188	1	[	[	X
ajst-25612	188	2	15	15	NUM
ajst-25612	188	3	]	]	X
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ajst-25612	188	5	j.	j.	PROPN
ajst-25612	188	6	et	et	PROPN
ajst-25612	188	7	al	al	PROPN
ajst-25612	188	8	.	.	PROPN
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ajst-25612	188	11	ζ	ζ	PROPN
ajst-25612	188	12	suppresses	suppress	VERB
ajst-25612	188	13	the	the	DET
ajst-25612	188	14	radiosensitivity	radiosensitivity	NOUN
ajst-25612	188	15	of	of	ADP
ajst-25612	188	16	glioma	glioma	NOUN
ajst-25612	188	17	cells	cell	NOUN
ajst-25612	188	18	by	by	ADP
ajst-25612	188	19	regulating	regulate	VERB
ajst-25612	188	20	the	the	DET
ajst-25612	188	21	pi3k	pi3k	PROPN
ajst-25612	188	22	/	/	SYM
ajst-25612	188	23	akt	akt	PROPN
ajst-25612	188	24	/	/	SYM
ajst-25612	188	25	mtor	mtor	PROPN
ajst-25612	188	26	pathway[j	pathway[j	PROPN
ajst-25612	188	27	]	]	PUNCT
ajst-25612	188	28	.	.	PUNCT
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ajst-25612	189	2	,	,	PUNCT
ajst-25612	189	3	2023	2023	NUM
ajst-25612	189	4	,	,	PUNCT
ajst-25612	189	5	56(1	56(1	NUM
ajst-25612	189	6	):	):	PUNCT
ajst-25612	189	7	2234101	2234101	NUM
ajst-25612	189	8	.	.	PUNCT
ajst-25612	190	1	[	[	X
ajst-25612	190	2	16	16	NUM
ajst-25612	190	3	]	]	X
ajst-25612	190	4	stephan	stephan	PROPN
ajst-25612	190	5	sauer	sauer	PROPN
ajst-25612	190	6	.	.	PUNCT
ajst-25612	191	1	et	et	PROPN
ajst-25612	191	2	al	al	PROPN
ajst-25612	191	3	.	.	PROPN
ajst-25612	191	4	t	t	PROPN
ajst-25612	191	5	cell	cell	NOUN
ajst-25612	191	6	receptor	receptor	NOUN
ajst-25612	191	7	signaling	signal	VERB
ajst-25612	191	8	controls	control	NOUN
ajst-25612	191	9	foxp3	foxp3	NOUN
ajst-25612	191	10	expression	expression	NOUN
ajst-25612	191	11	via	via	ADP
ajst-25612	191	12	pi3k	pi3k	PROPN
ajst-25612	191	13	,	,	PUNCT
ajst-25612	191	14	akt	akt	PROPN
ajst-25612	191	15	,	,	PUNCT
ajst-25612	191	16	and	and	CCONJ
ajst-25612	191	17	mtor[j	mtor[j	NOUN
ajst-25612	191	18	]	]	PUNCT
ajst-25612	191	19	.	.	PUNCT
ajst-25612	192	1	pnas	pna	NOUN
ajst-25612	192	2	,	,	PUNCT
ajst-25612	192	3	2008,105	2008,105	NUM
ajst-25612	192	4	(	(	PUNCT
ajst-25612	192	5	22	22	NUM
ajst-25612	192	6	):	):	PUNCT
ajst-25612	192	7	7797	7797	NUM
ajst-25612	192	8	-	-	SYM
ajst-25612	192	9	7802	7802	NUM
ajst-25612	192	10	.	.	PUNCT
ajst-25612	193	1	[	[	X
ajst-25612	193	2	17	17	NUM
ajst-25612	193	3	]	]	X
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ajst-25612	193	6	sánchez	sánchez	PROPN
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ajst-25612	194	9	to	to	PART
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ajst-25612	194	11	t	t	NOUN
ajst-25612	194	12	cell	cell	NOUN
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ajst-25612	194	14	and	and	CCONJ
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ajst-25612	194	16	graft	graft	NOUN
ajst-25612	194	17	-	-	PUNCT
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ajst-25612	194	21	]	]	PUNCT
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ajst-25612	201	3	]	]	X
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ajst-25612	202	5	-	-	SYM
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ajst-25612	203	3	]	]	PUNCT
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ajst-25612	203	18	jak	jak	PROPN
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ajst-25612	203	20	stat	stat	PROPN
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ajst-25612	203	22	pathways	pathway	NOUN
ajst-25612	203	23	and	and	CCONJ
ajst-25612	203	24	ido	ido	NOUN
ajst-25612	203	25	-	-	PUNCT
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ajst-25612	203	28	escape	escape	NOUN
ajst-25612	203	29	mechanism	mechanism	NOUN
ajst-25612	203	30	in	in	ADP
ajst-25612	203	31	endometrial	endometrial	ADJ
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ajst-25612	203	33	]	]	PUNCT
ajst-25612	203	34	.	.	PUNCT
ajst-25612	204	1	oncology	oncology	NOUN
ajst-25612	204	2	,	,	PUNCT
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ajst-25612	204	4	,	,	PUNCT
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ajst-25612	204	8	-	-	SYM
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ajst-25612	205	3	]	]	X
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ajst-25612	205	16	bcl2a1	bcl2a1	NOUN
ajst-25612	205	17	by	by	ADP
ajst-25612	205	18	targeting	target	VERB
ajst-25612	205	19	pi3k	pi3k	PROPN
ajst-25612	205	20	/	/	SYM
ajst-25612	205	21	akt	akt	NOUN
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ajst-25612	205	23	pathway	pathway	NOUN
ajst-25612	205	24	to	to	PART
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ajst-25612	205	28	]	]	PUNCT
ajst-25612	205	29	.	.	PUNCT
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ajst-25612	206	4	,	,	PUNCT
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ajst-25612	206	6	,	,	PUNCT
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ajst-25612	206	9	-	-	SYM
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ajst-25612	207	3	]	]	PUNCT
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ajst-25612	207	14	-	-	PUNCT
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ajst-25612	207	17	as	as	ADP
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ajst-25612	207	26	in	in	ADP
ajst-25612	207	27	dmmr	dmmr	PROPN
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ajst-25612	207	29	msi	msi	PROPN
ajst-25612	207	30	-	-	PROPN
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ajst-25612	207	34	]	]	PUNCT
ajst-25612	207	35	.	.	PUNCT
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ajst-25612	208	3	,	,	PUNCT
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ajst-25612	209	32	]	]	PUNCT
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ajst-25612	216	7	):	):	PUNCT
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ajst-25612	217	19	]	]	PUNCT
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ajst-25612	217	27	-	-	SYM
ajst-25612	217	28	1635	1635	NUM
ajst-25612	217	29	.	.	PUNCT