id	sid	tid	token	lemma	pos
ajst-25616	1	1	academic	academic	ADJ
ajst-25616	1	2	journal	journal	NOUN
ajst-25616	1	3	of	of	ADP
ajst-25616	1	4	science	science	NOUN
ajst-25616	1	5	and	and	CCONJ
ajst-25616	1	6	technology	technology	NOUN
ajst-25616	1	7	issn	issn	NOUN
ajst-25616	1	8	:	:	PUNCT
ajst-25616	1	9	2771	2771	NUM
ajst-25616	1	10	-	-	SYM
ajst-25616	1	11	3032	3032	NUM
ajst-25616	1	12	|	|	NOUN
ajst-25616	1	13	vol	vol	NOUN
ajst-25616	1	14	.	.	PROPN
ajst-25616	2	1	12	12	NUM
ajst-25616	2	2	,	,	PUNCT
ajst-25616	2	3	no	no	INTJ
ajst-25616	2	4	.	.	NOUN
ajst-25616	2	5	2	2	NUM
ajst-25616	2	6	,	,	PUNCT
ajst-25616	2	7	2024	2024	NUM
ajst-25616	2	8	184	184	NUM
ajst-25616	2	9	progress	progress	NOUN
ajst-25616	2	10	in	in	ADP
ajst-25616	2	11	the	the	DET
ajst-25616	2	12	application	application	NOUN
ajst-25616	2	13	of	of	ADP
ajst-25616	2	14	crispr	crispr	ADJ
ajst-25616	2	15	/	/	SYM
ajst-25616	2	16	cas	cas	PROPN
ajst-25616	2	17	family	family	NOUN
ajst-25616	2	18	mediated	mediate	VERB
ajst-25616	2	19	third‐generation	third‐generation	NOUN
ajst-25616	2	20	sequencing	sequencing	NOUN
ajst-25616	2	21	technology	technology	NOUN
ajst-25616	2	22	xizhen	xizhen	PROPN
ajst-25616	2	23	chen	chen	PROPN
ajst-25616	2	24	college	college	PROPN
ajst-25616	2	25	of	of	ADP
ajst-25616	2	26	life	life	PROPN
ajst-25616	2	27	sciences	sciences	PROPN
ajst-25616	2	28	,	,	PUNCT
ajst-25616	2	29	lanzhou	lanzhou	PROPN
ajst-25616	2	30	university	university	PROPN
ajst-25616	2	31	,	,	PUNCT
ajst-25616	2	32	lanzhou	lanzhou	PROPN
ajst-25616	2	33	730030	730030	NUM
ajst-25616	2	34	,	,	PUNCT
ajst-25616	2	35	china	china	PROPN
ajst-25616	2	36	abstract	abstract	PROPN
ajst-25616	2	37	:	:	PUNCT
ajst-25616	2	38	the	the	DET
ajst-25616	2	39	first	first	ADJ
ajst-25616	2	40	generation	generation	NOUN
ajst-25616	2	41	sequencing	sequence	VERB
ajst-25616	2	42	technology	technology	NOUN
ajst-25616	2	43	based	base	VERB
ajst-25616	2	44	on	on	ADP
ajst-25616	2	45	the	the	DET
ajst-25616	2	46	dideoxynucleotide	dideoxynucleotide	NOUN
ajst-25616	2	47	(	(	PUNCT
ajst-25616	2	48	ddntp	ddntp	NOUN
ajst-25616	2	49	)	)	PUNCT
ajst-25616	2	50	chain	chain	NOUN
ajst-25616	2	51	termination	termination	NOUN
ajst-25616	2	52	method	method	NOUN
ajst-25616	2	53	proposed	propose	VERB
ajst-25616	2	54	by	by	ADP
ajst-25616	2	55	sanger	sanger	PROPN
ajst-25616	2	56	was	be	AUX
ajst-25616	2	57	gradually	gradually	ADV
ajst-25616	2	58	eliminated	eliminate	VERB
ajst-25616	2	59	due	due	ADP
ajst-25616	2	60	to	to	ADP
ajst-25616	2	61	its	its	PRON
ajst-25616	2	62	high	high	ADJ
ajst-25616	2	63	cost	cost	NOUN
ajst-25616	2	64	,	,	PUNCT
ajst-25616	2	65	low	low	ADJ
ajst-25616	2	66	sequencing	sequencing	NOUN
ajst-25616	2	67	read	read	NOUN
ajst-25616	2	68	length	length	NOUN
ajst-25616	2	69	and	and	CCONJ
ajst-25616	2	70	cumbersome	cumbersome	ADJ
ajst-25616	2	71	process	process	NOUN
ajst-25616	2	72	.	.	PUNCT
ajst-25616	3	1	the	the	DET
ajst-25616	3	2	second	second	ADJ
ajst-25616	3	3	generation	generation	NOUN
ajst-25616	3	4	of	of	ADP
ajst-25616	3	5	sequencing	sequence	VERB
ajst-25616	3	6	technology	technology	NOUN
ajst-25616	3	7	,	,	PUNCT
ajst-25616	3	8	called	call	VERB
ajst-25616	3	9	high	high	ADJ
ajst-25616	3	10	-	-	PUNCT
ajst-25616	3	11	throughput	throughput	NOUN
ajst-25616	3	12	sequencing	sequence	VERB
ajst-25616	3	13	(	(	PUNCT
ajst-25616	3	14	hts	ht	NOUN
ajst-25616	3	15	)	)	PUNCT
ajst-25616	3	16	,	,	PUNCT
ajst-25616	3	17	which	which	PRON
ajst-25616	3	18	was	be	AUX
ajst-25616	3	19	then	then	ADV
ajst-25616	3	20	developed	develop	VERB
ajst-25616	3	21	,	,	PUNCT
ajst-25616	3	22	still	still	ADV
ajst-25616	3	23	has	have	VERB
ajst-25616	3	24	the	the	DET
ajst-25616	3	25	problem	problem	NOUN
ajst-25616	3	26	of	of	ADP
ajst-25616	3	27	fixed	fix	VERB
ajst-25616	3	28	read	read	NOUN
ajst-25616	3	29	length	length	NOUN
ajst-25616	3	30	.	.	PUNCT
ajst-25616	4	1	in	in	ADP
ajst-25616	4	2	recent	recent	ADJ
ajst-25616	4	3	years	year	NOUN
ajst-25616	4	4	,	,	PUNCT
ajst-25616	4	5	the	the	DET
ajst-25616	4	6	third	third	ADJ
ajst-25616	4	7	generation	generation	NOUN
ajst-25616	4	8	sequencing	sequence	VERB
ajst-25616	4	9	technology	technology	NOUN
ajst-25616	4	10	represented	represent	VERB
ajst-25616	4	11	by	by	ADP
ajst-25616	4	12	smrt	smrt	NOUN
ajst-25616	4	13	technology	technology	NOUN
ajst-25616	4	14	and	and	CCONJ
ajst-25616	4	15	nanopore	nanopore	ADV
ajst-25616	4	16	sequencing	sequence	VERB
ajst-25616	4	17	technology	technology	NOUN
ajst-25616	4	18	has	have	AUX
ajst-25616	4	19	gradually	gradually	ADV
ajst-25616	4	20	become	become	VERB
ajst-25616	4	21	popular	popular	ADJ
ajst-25616	4	22	.	.	PUNCT
ajst-25616	5	1	compared	compare	VERB
ajst-25616	5	2	with	with	ADP
ajst-25616	5	3	the	the	DET
ajst-25616	5	4	previous	previous	ADJ
ajst-25616	5	5	two	two	NUM
ajst-25616	5	6	generations	generation	NOUN
ajst-25616	5	7	of	of	ADP
ajst-25616	5	8	sequencing	sequence	VERB
ajst-25616	5	9	technology	technology	NOUN
ajst-25616	5	10	,	,	PUNCT
ajst-25616	5	11	the	the	DET
ajst-25616	5	12	most	most	ADV
ajst-25616	5	13	significant	significant	ADJ
ajst-25616	5	14	advantage	advantage	NOUN
ajst-25616	5	15	of	of	ADP
ajst-25616	5	16	the	the	DET
ajst-25616	5	17	third	third	ADJ
ajst-25616	5	18	generation	generation	NOUN
ajst-25616	5	19	sequencing	sequence	VERB
ajst-25616	5	20	technology	technology	NOUN
ajst-25616	5	21	is	be	AUX
ajst-25616	5	22	its	its	PRON
ajst-25616	5	23	ability	ability	NOUN
ajst-25616	5	24	to	to	PART
ajst-25616	5	25	carry	carry	VERB
ajst-25616	5	26	out	out	ADP
ajst-25616	5	27	single	single	ADJ
ajst-25616	5	28	molecule	molecule	NOUN
ajst-25616	5	29	sequencing	sequencing	NOUN
ajst-25616	5	30	.	.	PUNCT
ajst-25616	6	1	in	in	ADP
ajst-25616	6	2	this	this	DET
ajst-25616	6	3	process	process	NOUN
ajst-25616	6	4	,	,	PUNCT
ajst-25616	6	5	the	the	DET
ajst-25616	6	6	infinite	infinite	ADJ
ajst-25616	6	7	length	length	NOUN
ajst-25616	6	8	of	of	ADP
ajst-25616	6	9	nucleic	nucleic	ADJ
ajst-25616	6	10	acid	acid	NOUN
ajst-25616	6	11	sequence	sequence	NOUN
ajst-25616	6	12	can	can	AUX
ajst-25616	6	13	be	be	AUX
ajst-25616	6	14	determined	determine	VERB
ajst-25616	6	15	theoretically	theoretically	ADV
ajst-25616	6	16	without	without	ADP
ajst-25616	6	17	the	the	DET
ajst-25616	6	18	help	help	NOUN
ajst-25616	6	19	of	of	ADP
ajst-25616	6	20	pcr	pcr	ADJ
ajst-25616	6	21	amplification	amplification	NOUN
ajst-25616	6	22	.	.	PUNCT
ajst-25616	7	1	this	this	DET
ajst-25616	7	2	paper	paper	NOUN
ajst-25616	7	3	first	first	ADV
ajst-25616	7	4	introduces	introduce	VERB
ajst-25616	7	5	the	the	DET
ajst-25616	7	6	basic	basic	ADJ
ajst-25616	7	7	principles	principle	NOUN
ajst-25616	7	8	,	,	PUNCT
ajst-25616	7	9	advantages	advantage	NOUN
ajst-25616	7	10	and	and	CCONJ
ajst-25616	7	11	disadvantages	disadvantage	NOUN
ajst-25616	7	12	of	of	ADP
ajst-25616	7	13	third	third	ADJ
ajst-25616	7	14	-	-	PUNCT
ajst-25616	7	15	generation	generation	NOUN
ajst-25616	7	16	sequencing	sequencing	NOUN
ajst-25616	7	17	,	,	PUNCT
ajst-25616	7	18	and	and	CCONJ
ajst-25616	7	19	introduces	introduce	NOUN
ajst-25616	7	20	in	in	ADP
ajst-25616	7	21	detail	detail	NOUN
ajst-25616	7	22	the	the	DET
ajst-25616	7	23	crispr	crispr	ADJ
ajst-25616	7	24	/	/	SYM
ajst-25616	7	25	cas	cas	PROPN
ajst-25616	7	26	family	family	NOUN
ajst-25616	7	27	-	-	PUNCT
ajst-25616	7	28	mediated	mediate	VERB
ajst-25616	7	29	smrt	smrt	NOUN
ajst-25616	7	30	technology	technology	NOUN
ajst-25616	7	31	and	and	CCONJ
ajst-25616	7	32	nanopore	nanopore	ADV
ajst-25616	7	33	sequencing	sequence	VERB
ajst-25616	7	34	technology	technology	NOUN
ajst-25616	7	35	in	in	ADP
ajst-25616	7	36	the	the	DET
ajst-25616	7	37	thirdgeneration	thirdgeneration	NOUN
ajst-25616	7	38	sequencing	sequence	VERB
ajst-25616	7	39	technology	technology	NOUN
ajst-25616	7	40	.	.	PUNCT
ajst-25616	8	1	finally	finally	ADV
ajst-25616	8	2	,	,	PUNCT
ajst-25616	8	3	the	the	DET
ajst-25616	8	4	research	research	NOUN
ajst-25616	8	5	progress	progress	NOUN
ajst-25616	8	6	and	and	CCONJ
ajst-25616	8	7	prospects	prospect	NOUN
ajst-25616	8	8	of	of	ADP
ajst-25616	8	9	the	the	DET
ajst-25616	8	10	combination	combination	NOUN
ajst-25616	8	11	of	of	ADP
ajst-25616	8	12	the	the	DET
ajst-25616	8	13	third	third	ADJ
ajst-25616	8	14	generation	generation	NOUN
ajst-25616	8	15	sequencing	sequence	VERB
ajst-25616	8	16	technology	technology	NOUN
ajst-25616	8	17	and	and	CCONJ
ajst-25616	8	18	gene	gene	NOUN
ajst-25616	8	19	editing	edit	VERB
ajst-25616	8	20	technology	technology	NOUN
ajst-25616	8	21	in	in	ADP
ajst-25616	8	22	the	the	DET
ajst-25616	8	23	future	future	NOUN
ajst-25616	8	24	are	be	AUX
ajst-25616	8	25	analyzed	analyze	VERB
ajst-25616	8	26	.	.	PUNCT
ajst-25616	9	1	keywords	keyword	NOUN
ajst-25616	9	2	:	:	PUNCT
ajst-25616	9	3	sequencing	sequence	VERB
ajst-25616	9	4	technology	technology	NOUN
ajst-25616	9	5	;	;	PUNCT
ajst-25616	9	6	smrt	smrt	NOUN
ajst-25616	9	7	technology	technology	NOUN
ajst-25616	9	8	;	;	PUNCT
ajst-25616	9	9	nanopore	nanopore	ADV
ajst-25616	9	10	sequencing	sequence	VERB
ajst-25616	9	11	technology	technology	NOUN
ajst-25616	9	12	;	;	PUNCT
ajst-25616	9	13	the	the	DET
ajst-25616	9	14	crispr	crispr	NOUN
ajst-25616	9	15	/	/	SYM
ajst-25616	9	16	cas	cas	PROPN
ajst-25616	9	17	family	family	NOUN
ajst-25616	9	18	.	.	PUNCT
ajst-25616	10	1	1	1	X
ajst-25616	10	2	.	.	X
ajst-25616	10	3	introduction	introduction	NOUN
ajst-25616	10	4	as	as	ADP
ajst-25616	10	5	human	human	ADJ
ajst-25616	10	6	understanding	understanding	NOUN
ajst-25616	10	7	of	of	ADP
ajst-25616	10	8	the	the	DET
ajst-25616	10	9	genome	genome	NOUN
ajst-25616	10	10	deepens	deepen	VERB
ajst-25616	10	11	,	,	PUNCT
ajst-25616	10	12	genomics	genomic	NOUN
ajst-25616	10	13	has	have	AUX
ajst-25616	10	14	become	become	VERB
ajst-25616	10	15	the	the	DET
ajst-25616	10	16	key	key	NOUN
ajst-25616	10	17	to	to	ADP
ajst-25616	10	18	comprehending	comprehend	VERB
ajst-25616	10	19	the	the	DET
ajst-25616	10	20	complexity	complexity	NOUN
ajst-25616	10	21	of	of	ADP
ajst-25616	10	22	living	live	VERB
ajst-25616	10	23	organisms	organism	NOUN
ajst-25616	10	24	.	.	PUNCT
ajst-25616	11	1	the	the	DET
ajst-25616	11	2	diversity	diversity	NOUN
ajst-25616	11	3	of	of	ADP
ajst-25616	11	4	microbial	microbial	ADJ
ajst-25616	11	5	communities	community	NOUN
ajst-25616	11	6	,	,	PUNCT
ajst-25616	11	7	the	the	DET
ajst-25616	11	8	origins	origin	NOUN
ajst-25616	11	9	of	of	ADP
ajst-25616	11	10	genetic	genetic	ADJ
ajst-25616	11	11	diseases	disease	NOUN
ajst-25616	11	12	,	,	PUNCT
ajst-25616	11	13	and	and	CCONJ
ajst-25616	11	14	the	the	DET
ajst-25616	11	15	paths	path	NOUN
ajst-25616	11	16	of	of	ADP
ajst-25616	11	17	biological	biological	ADJ
ajst-25616	11	18	evolution	evolution	NOUN
ajst-25616	11	19	[	[	X
ajst-25616	11	20	1	1	NUM
ajst-25616	11	21	]	]	PUNCT
ajst-25616	11	22	are	be	AUX
ajst-25616	11	23	all	all	ADV
ajst-25616	11	24	directly	directly	ADV
ajst-25616	11	25	related	relate	VERB
ajst-25616	11	26	to	to	ADP
ajst-25616	11	27	the	the	DET
ajst-25616	11	28	genome	genome	NOUN
ajst-25616	11	29	sequence	sequence	NOUN
ajst-25616	11	30	.	.	PUNCT
ajst-25616	12	1	in	in	ADP
ajst-25616	12	2	order	order	NOUN
ajst-25616	12	3	to	to	PART
ajst-25616	12	4	accurately	accurately	ADV
ajst-25616	12	5	read	read	VERB
ajst-25616	12	6	the	the	DET
ajst-25616	12	7	target	target	NOUN
ajst-25616	12	8	gene	gene	NOUN
ajst-25616	12	9	sequences	sequence	NOUN
ajst-25616	12	10	inside	inside	ADP
ajst-25616	12	11	and	and	CCONJ
ajst-25616	12	12	outside	outside	ADP
ajst-25616	12	13	the	the	DET
ajst-25616	12	14	body	body	NOUN
ajst-25616	12	15	as	as	ADV
ajst-25616	12	16	well	well	ADV
ajst-25616	12	17	as	as	ADP
ajst-25616	12	18	the	the	DET
ajst-25616	12	19	changes	change	NOUN
ajst-25616	12	20	in	in	ADP
ajst-25616	12	21	epigenetic	epigenetic	ADJ
ajst-25616	12	22	modifications	modification	NOUN
ajst-25616	12	23	of	of	ADP
ajst-25616	12	24	genes	gene	NOUN
ajst-25616	12	25	[	[	X
ajst-25616	12	26	2	2	NUM
ajst-25616	12	27	]	]	PUNCT
ajst-25616	12	28	,	,	PUNCT
ajst-25616	12	29	researchers	researcher	NOUN
ajst-25616	12	30	have	have	AUX
ajst-25616	12	31	been	be	AUX
ajst-25616	12	32	exploring	explore	VERB
ajst-25616	12	33	new	new	ADJ
ajst-25616	12	34	high	high	ADJ
ajst-25616	12	35	-	-	PUNCT
ajst-25616	12	36	tech	tech	NOUN
ajst-25616	12	37	sequencing	sequence	VERB
ajst-25616	12	38	technologies	technology	NOUN
ajst-25616	12	39	with	with	ADP
ajst-25616	12	40	higher	high	ADJ
ajst-25616	12	41	accuracy	accuracy	NOUN
ajst-25616	12	42	,	,	PUNCT
ajst-25616	12	43	broader	broad	ADJ
ajst-25616	12	44	sequencing	sequence	VERB
ajst-25616	12	45	range	range	NOUN
ajst-25616	12	46	,	,	PUNCT
ajst-25616	12	47	and	and	CCONJ
ajst-25616	12	48	fewer	few	ADJ
ajst-25616	12	49	interfering	interfere	VERB
ajst-25616	12	50	factors	factor	NOUN
ajst-25616	12	51	.	.	PUNCT
ajst-25616	13	1	the	the	DET
ajst-25616	13	2	first	first	ADJ
ajst-25616	13	3	-	-	PUNCT
ajst-25616	13	4	generation	generation	NOUN
ajst-25616	13	5	sequencing	sequence	VERB
ajst-25616	13	6	technology	technology	NOUN
ajst-25616	13	7	invented	invent	VERB
ajst-25616	13	8	by	by	ADP
ajst-25616	13	9	sanger	sanger	PROPN
ajst-25616	13	10	and	and	CCONJ
ajst-25616	13	11	others	other	NOUN
ajst-25616	13	12	,	,	PUNCT
ajst-25616	13	13	despite	despite	SCONJ
ajst-25616	13	14	its	its	PRON
ajst-25616	13	15	milestone	milestone	NOUN
ajst-25616	13	16	significance	significance	NOUN
ajst-25616	13	17	in	in	ADP
ajst-25616	13	18	history	history	NOUN
ajst-25616	13	19	,	,	PUNCT
ajst-25616	13	20	was	be	AUX
ajst-25616	13	21	limited	limit	VERB
ajst-25616	13	22	by	by	ADP
ajst-25616	13	23	its	its	PRON
ajst-25616	13	24	high	high	ADJ
ajst-25616	13	25	cost	cost	NOUN
ajst-25616	13	26	,	,	PUNCT
ajst-25616	13	27	low	low	ADJ
ajst-25616	13	28	efficiency	efficiency	NOUN
ajst-25616	13	29	,	,	PUNCT
ajst-25616	13	30	short	short	ADJ
ajst-25616	13	31	read	read	NOUN
ajst-25616	13	32	lengths	length	NOUN
ajst-25616	13	33	,	,	PUNCT
ajst-25616	13	34	and	and	CCONJ
ajst-25616	13	35	low	low	ADJ
ajst-25616	13	36	throughput	throughput	NOUN
ajst-25616	13	37	.	.	PUNCT
ajst-25616	14	1	although	although	SCONJ
ajst-25616	14	2	it	it	PRON
ajst-25616	14	3	was	be	AUX
ajst-25616	14	4	a	a	DET
ajst-25616	14	5	sensation	sensation	NOUN
ajst-25616	14	6	at	at	ADP
ajst-25616	14	7	the	the	DET
ajst-25616	14	8	time	time	NOUN
ajst-25616	14	9	,	,	PUNCT
ajst-25616	14	10	it	it	PRON
ajst-25616	14	11	could	could	AUX
ajst-25616	14	12	not	not	PART
ajst-25616	14	13	be	be	AUX
ajst-25616	14	14	widely	widely	ADV
ajst-25616	14	15	applied	apply	VERB
ajst-25616	14	16	,	,	PUNCT
ajst-25616	14	17	thus	thus	ADV
ajst-25616	14	18	heralding	herald	VERB
ajst-25616	14	19	the	the	DET
ajst-25616	14	20	development	development	NOUN
ajst-25616	14	21	of	of	ADP
ajst-25616	14	22	high	high	ADJ
ajst-25616	14	23	-	-	PUNCT
ajst-25616	14	24	throughput	throughput	NOUN
ajst-25616	14	25	sequencing	sequence	VERB
ajst-25616	14	26	technologies	technology	NOUN
ajst-25616	14	27	.	.	PUNCT
ajst-25616	15	1	the	the	DET
ajst-25616	15	2	emergence	emergence	NOUN
ajst-25616	15	3	of	of	ADP
ajst-25616	15	4	second	second	ADJ
ajst-25616	15	5	-	-	PUNCT
ajst-25616	15	6	generation	generation	NOUN
ajst-25616	15	7	sequencing	sequence	VERB
ajst-25616	15	8	technology	technology	NOUN
ajst-25616	15	9	(	(	PUNCT
ajst-25616	15	10	hts	hts	PROPN
ajst-25616	15	11	)	)	PUNCT
ajst-25616	15	12	greatly	greatly	ADV
ajst-25616	15	13	reduced	reduce	VERB
ajst-25616	15	14	sequencing	sequencing	NOUN
ajst-25616	15	15	costs	cost	NOUN
ajst-25616	15	16	and	and	CCONJ
ajst-25616	15	17	increased	increase	VERB
ajst-25616	15	18	data	datum	NOUN
ajst-25616	15	19	output	output	NOUN
ajst-25616	15	20	,	,	PUNCT
ajst-25616	15	21	but	but	CCONJ
ajst-25616	15	22	it	it	PRON
ajst-25616	15	23	still	still	ADV
ajst-25616	15	24	did	do	AUX
ajst-25616	15	25	not	not	PART
ajst-25616	15	26	solve	solve	VERB
ajst-25616	15	27	the	the	DET
ajst-25616	15	28	problem	problem	NOUN
ajst-25616	15	29	of	of	ADP
ajst-25616	15	30	short	short	ADJ
ajst-25616	15	31	read	read	NOUN
ajst-25616	15	32	lengths	length	NOUN
ajst-25616	15	33	,	,	PUNCT
ajst-25616	15	34	and	and	CCONJ
ajst-25616	15	35	therefore	therefore	ADV
ajst-25616	15	36	still	still	ADV
ajst-25616	15	37	had	have	VERB
ajst-25616	15	38	certain	certain	ADJ
ajst-25616	15	39	limitations	limitation	NOUN
ajst-25616	15	40	,	,	PUNCT
ajst-25616	15	41	unable	unable	ADJ
ajst-25616	15	42	to	to	PART
ajst-25616	15	43	measure	measure	VERB
ajst-25616	15	44	high	high	ADJ
ajst-25616	15	45	cg	cg	NOUN
ajst-25616	15	46	regions	region	NOUN
ajst-25616	15	47	and	and	CCONJ
ajst-25616	15	48	some	some	DET
ajst-25616	15	49	complex	complex	ADJ
ajst-25616	15	50	target	target	NOUN
ajst-25616	15	51	areas	area	NOUN
ajst-25616	15	52	.	.	PUNCT
ajst-25616	16	1	in	in	ADP
ajst-25616	16	2	recent	recent	ADJ
ajst-25616	16	3	years	year	NOUN
ajst-25616	16	4	,	,	PUNCT
ajst-25616	16	5	with	with	ADP
ajst-25616	16	6	single	single	ADJ
ajst-25616	16	7	-	-	PUNCT
ajst-25616	16	8	molecule	molecule	NOUN
ajst-25616	16	9	sequencing	sequencing	NOUN
ajst-25616	16	10	(	(	PUNCT
ajst-25616	16	11	smrt	smrt	NOUN
ajst-25616	16	12	sequencing	sequencing	NOUN
ajst-25616	16	13	)	)	PUNCT
ajst-25616	16	14	and	and	CCONJ
ajst-25616	16	15	nanopore	nanopore	ADV
ajst-25616	16	16	sequencing	sequence	VERB
ajst-25616	16	17	leading	lead	VERB
ajst-25616	16	18	the	the	DET
ajst-25616	16	19	way	way	NOUN
ajst-25616	16	20	,	,	PUNCT
ajst-25616	16	21	the	the	DET
ajst-25616	16	22	third	third	ADJ
ajst-25616	16	23	-	-	PUNCT
ajst-25616	16	24	generation	generation	NOUN
ajst-25616	16	25	sequencing	sequence	VERB
ajst-25616	16	26	technology	technology	NOUN
ajst-25616	16	27	has	have	AUX
ajst-25616	16	28	emerged	emerge	VERB
ajst-25616	16	29	.	.	PUNCT
ajst-25616	17	1	this	this	DET
ajst-25616	17	2	technology	technology	NOUN
ajst-25616	17	3	has	have	AUX
ajst-25616	17	4	changed	change	VERB
ajst-25616	17	5	the	the	DET
ajst-25616	17	6	previous	previous	ADJ
ajst-25616	17	7	limitations	limitation	NOUN
ajst-25616	17	8	of	of	ADP
ajst-25616	17	9	sequencing	sequence	VERB
ajst-25616	17	10	technology	technology	NOUN
ajst-25616	17	11	that	that	PRON
ajst-25616	17	12	was	be	AUX
ajst-25616	17	13	bound	bind	VERB
ajst-25616	17	14	to	to	ADP
ajst-25616	17	15	pcr	pcr	ADJ
ajst-25616	17	16	amplification	amplification	NOUN
ajst-25616	17	17	,	,	PUNCT
ajst-25616	17	18	and	and	CCONJ
ajst-25616	17	19	its	its	PRON
ajst-25616	17	20	high	high	ADJ
ajst-25616	17	21	throughput	throughput	NOUN
ajst-25616	17	22	,	,	PUNCT
ajst-25616	17	23	long	long	ADV
ajst-25616	17	24	read	read	VERB
ajst-25616	17	25	length	length	NOUN
ajst-25616	17	26	,	,	PUNCT
ajst-25616	17	27	and	and	CCONJ
ajst-25616	17	28	no	no	DET
ajst-25616	17	29	amplification	amplification	NOUN
ajst-25616	17	30	are	be	AUX
ajst-25616	17	31	its	its	PRON
ajst-25616	17	32	highlights	highlight	NOUN
ajst-25616	17	33	,	,	PUNCT
ajst-25616	17	34	quickly	quickly	ADV
ajst-25616	17	35	promoting	promote	VERB
ajst-25616	17	36	it	it	PRON
ajst-25616	17	37	in	in	ADP
ajst-25616	17	38	the	the	DET
ajst-25616	17	39	field	field	NOUN
ajst-25616	17	40	of	of	ADP
ajst-25616	17	41	molecular	molecular	ADJ
ajst-25616	17	42	biology	biology	NOUN
ajst-25616	17	43	.	.	PUNCT
ajst-25616	18	1	however	however	ADV
ajst-25616	18	2	,	,	PUNCT
ajst-25616	18	3	the	the	DET
ajst-25616	18	4	downside	downside	NOUN
ajst-25616	18	5	is	be	AUX
ajst-25616	18	6	that	that	SCONJ
ajst-25616	18	7	due	due	ADP
ajst-25616	18	8	to	to	ADP
ajst-25616	18	9	its	its	PRON
ajst-25616	18	10	higher	high	ADJ
ajst-25616	18	11	error	error	NOUN
ajst-25616	18	12	rate	rate	NOUN
ajst-25616	18	13	compared	compare	VERB
ajst-25616	18	14	to	to	ADP
ajst-25616	18	15	the	the	DET
ajst-25616	18	16	previous	previous	ADJ
ajst-25616	18	17	two	two	NUM
ajst-25616	18	18	generations	generation	NOUN
ajst-25616	18	19	of	of	ADP
ajst-25616	18	20	sequencing	sequence	VERB
ajst-25616	18	21	technologies	technology	NOUN
ajst-25616	18	22	,	,	PUNCT
ajst-25616	18	23	it	it	PRON
ajst-25616	18	24	is	be	AUX
ajst-25616	18	25	far	far	ADV
ajst-25616	18	26	less	less	ADV
ajst-25616	18	27	practical	practical	ADJ
ajst-25616	18	28	than	than	ADP
ajst-25616	18	29	the	the	DET
ajst-25616	18	30	second	second	ADJ
ajst-25616	18	31	-	-	PUNCT
ajst-25616	18	32	generation	generation	NOUN
ajst-25616	18	33	sequencing	sequence	VERB
ajst-25616	18	34	technology	technology	NOUN
ajst-25616	18	35	when	when	SCONJ
ajst-25616	18	36	high	high	ADJ
ajst-25616	18	37	-	-	PUNCT
ajst-25616	18	38	precision	precision	NOUN
ajst-25616	18	39	measurement	measurement	NOUN
ajst-25616	18	40	is	be	AUX
ajst-25616	18	41	required	require	VERB
ajst-25616	18	42	.	.	PUNCT
ajst-25616	19	1	at	at	ADP
ajst-25616	19	2	this	this	DET
ajst-25616	19	3	time	time	NOUN
ajst-25616	19	4	,	,	PUNCT
ajst-25616	19	5	the	the	DET
ajst-25616	19	6	discovery	discovery	NOUN
ajst-25616	19	7	of	of	ADP
ajst-25616	19	8	the	the	DET
ajst-25616	19	9	crispr	crispr	ADJ
ajst-25616	19	10	/	/	SYM
ajst-25616	19	11	cas	cas	NOUN
ajst-25616	19	12	system	system	NOUN
ajst-25616	19	13	,	,	PUNCT
ajst-25616	19	14	especially	especially	ADV
ajst-25616	19	15	the	the	DET
ajst-25616	19	16	proteins	protein	NOUN
ajst-25616	19	17	cas9	cas9	NOUN
ajst-25616	19	18	,	,	PUNCT
ajst-25616	19	19	cas12	cas12	NOUN
ajst-25616	19	20	,	,	PUNCT
ajst-25616	19	21	and	and	CCONJ
ajst-25616	19	22	cas13	cas13	PROPN
ajst-25616	19	23	,	,	PUNCT
ajst-25616	19	24	has	have	AUX
ajst-25616	19	25	brought	bring	VERB
ajst-25616	19	26	revolutionary	revolutionary	ADJ
ajst-25616	19	27	tools	tool	NOUN
ajst-25616	19	28	to	to	PART
ajst-25616	19	29	gene	gene	VERB
ajst-25616	19	30	editing	edit	VERB
ajst-25616	19	31	technology	technology	NOUN
ajst-25616	19	32	.	.	PUNCT
ajst-25616	20	1	they	they	PRON
ajst-25616	20	2	are	be	AUX
ajst-25616	20	3	highly	highly	ADV
ajst-25616	20	4	target	target	NOUN
ajst-25616	20	5	-	-	PUNCT
ajst-25616	20	6	specific	specific	NOUN
ajst-25616	20	7	with	with	ADP
ajst-25616	20	8	a	a	DET
ajst-25616	20	9	low	low	ADJ
ajst-25616	20	10	off	off	ADP
ajst-25616	20	11	-	-	PUNCT
ajst-25616	20	12	target	target	NOUN
ajst-25616	20	13	rate	rate	NOUN
ajst-25616	20	14	,	,	PUNCT
ajst-25616	20	15	easy	easy	ADJ
ajst-25616	20	16	to	to	PART
ajst-25616	20	17	use	use	VERB
ajst-25616	20	18	,	,	PUNCT
ajst-25616	20	19	and	and	CCONJ
ajst-25616	20	20	when	when	SCONJ
ajst-25616	20	21	combined	combine	VERB
ajst-25616	20	22	with	with	ADP
ajst-25616	20	23	third	third	ADJ
ajst-25616	20	24	-	-	PUNCT
ajst-25616	20	25	generation	generation	NOUN
ajst-25616	20	26	sequencing	sequence	VERB
ajst-25616	20	27	technology	technology	NOUN
ajst-25616	20	28	to	to	PART
ajst-25616	20	29	enhance	enhance	VERB
ajst-25616	20	30	their	their	PRON
ajst-25616	20	31	targeting	targeting	NOUN
ajst-25616	20	32	,	,	PUNCT
ajst-25616	20	33	the	the	DET
ajst-25616	20	34	application	application	NOUN
ajst-25616	20	35	range	range	NOUN
ajst-25616	20	36	of	of	ADP
ajst-25616	20	37	this	this	DET
ajst-25616	20	38	system	system	NOUN
ajst-25616	20	39	has	have	AUX
ajst-25616	20	40	been	be	AUX
ajst-25616	20	41	expanded	expand	VERB
ajst-25616	20	42	like	like	ADP
ajst-25616	20	43	never	never	ADV
ajst-25616	20	44	before	before	ADV
ajst-25616	20	45	,	,	PUNCT
ajst-25616	20	46	from	from	ADP
ajst-25616	20	47	basic	basic	ADJ
ajst-25616	20	48	gene	gene	NOUN
ajst-25616	20	49	function	function	NOUN
ajst-25616	20	50	research	research	NOUN
ajst-25616	20	51	to	to	ADP
ajst-25616	20	52	complex	complex	ADJ
ajst-25616	20	53	disease	disease	NOUN
ajst-25616	20	54	treatment	treatment	NOUN
ajst-25616	20	55	.	.	PUNCT
ajst-25616	21	1	this	this	DET
ajst-25616	21	2	study	study	NOUN
ajst-25616	21	3	aims	aim	VERB
ajst-25616	21	4	to	to	PART
ajst-25616	21	5	explore	explore	VERB
ajst-25616	21	6	the	the	DET
ajst-25616	21	7	potential	potential	NOUN
ajst-25616	21	8	and	and	CCONJ
ajst-25616	21	9	applications	application	NOUN
ajst-25616	21	10	of	of	ADP
ajst-25616	21	11	the	the	DET
ajst-25616	21	12	combination	combination	NOUN
ajst-25616	21	13	of	of	ADP
ajst-25616	21	14	the	the	DET
ajst-25616	21	15	crispr	crispr	ADJ
ajst-25616	21	16	/	/	SYM
ajst-25616	21	17	cas	cas	NOUN
ajst-25616	21	18	system	system	NOUN
ajst-25616	21	19	with	with	ADP
ajst-25616	21	20	third	third	ADJ
ajst-25616	21	21	-	-	PUNCT
ajst-25616	21	22	generation	generation	NOUN
ajst-25616	21	23	sequencing	sequence	VERB
ajst-25616	21	24	technology	technology	NOUN
ajst-25616	21	25	.	.	PUNCT
ajst-25616	22	1	2	2	X
ajst-25616	22	2	.	.	X
ajst-25616	22	3	an	an	DET
ajst-25616	22	4	overview	overview	NOUN
ajst-25616	22	5	of	of	ADP
ajst-25616	22	6	crispr	crispr	ADJ
ajst-25616	22	7	/	/	SYM
ajst-25616	22	8	cas	cas	PROPN
ajst-25616	22	9	technology	technology	NOUN
ajst-25616	22	10	2.1	2.1	NUM
ajst-25616	22	11	.	.	PUNCT
ajst-25616	23	1	types	type	NOUN
ajst-25616	23	2	of	of	ADP
ajst-25616	23	3	crispr	crispr	ADJ
ajst-25616	23	4	/	/	SYM
ajst-25616	23	5	cas	cas	NOUN
ajst-25616	23	6	gene	gene	NOUN
ajst-25616	23	7	editing	edit	VERB
ajst-25616	23	8	tools	tool	NOUN
ajst-25616	23	9	the	the	DET
ajst-25616	23	10	types	type	NOUN
ajst-25616	23	11	of	of	ADP
ajst-25616	23	12	crispr	crispr	ADJ
ajst-25616	23	13	/	/	SYM
ajst-25616	23	14	cas	cas	PROPN
ajst-25616	23	15	systems	system	NOUN
ajst-25616	23	16	found	find	VERB
ajst-25616	23	17	in	in	ADP
ajst-25616	23	18	nature	nature	NOUN
ajst-25616	23	19	are	be	AUX
ajst-25616	23	20	rich	rich	ADJ
ajst-25616	23	21	and	and	CCONJ
ajst-25616	23	22	diverse	diverse	ADJ
ajst-25616	23	23	,	,	PUNCT
ajst-25616	23	24	and	and	CCONJ
ajst-25616	23	25	they	they	PRON
ajst-25616	23	26	can	can	AUX
ajst-25616	23	27	be	be	AUX
ajst-25616	23	28	broadly	broadly	ADV
ajst-25616	23	29	divided	divide	VERB
ajst-25616	23	30	into	into	ADP
ajst-25616	23	31	two	two	NUM
ajst-25616	23	32	classes	class	NOUN
ajst-25616	23	33	based	base	VERB
ajst-25616	23	34	on	on	ADP
ajst-25616	23	35	their	their	PRON
ajst-25616	23	36	protein	protein	NOUN
ajst-25616	23	37	effectors	effector	NOUN
ajst-25616	23	38	,	,	PUNCT
ajst-25616	23	39	with	with	ADP
ajst-25616	23	40	six	six	NUM
ajst-25616	23	41	types	type	NOUN
ajst-25616	23	42	and	and	CCONJ
ajst-25616	23	43	various	various	ADJ
ajst-25616	23	44	subtypes	subtype	NOUN
ajst-25616	23	45	[	[	X
ajst-25616	23	46	2	2	NUM
ajst-25616	23	47	]	]	PUNCT
ajst-25616	23	48	.	.	PUNCT
ajst-25616	24	1	class	class	NOUN
ajst-25616	24	2	i	i	PRON
ajst-25616	24	3	includes	include	VERB
ajst-25616	24	4	types	type	NOUN
ajst-25616	24	5	i	i	PRON
ajst-25616	24	6	,	,	PUNCT
ajst-25616	24	7	iii	iii	PROPN
ajst-25616	24	8	,	,	PUNCT
ajst-25616	24	9	and	and	CCONJ
ajst-25616	24	10	iv	iv	X
ajst-25616	24	11	,	,	PUNCT
ajst-25616	24	12	which	which	PRON
ajst-25616	24	13	need	need	VERB
ajst-25616	24	14	multiple	multiple	ADJ
ajst-25616	24	15	cas	cas	NOUN
ajst-25616	24	16	proteins	protein	NOUN
ajst-25616	24	17	to	to	PART
ajst-25616	24	18	form	form	VERB
ajst-25616	24	19	a	a	DET
ajst-25616	24	20	multi	multi	ADJ
ajst-25616	24	21	-	-	ADJ
ajst-25616	24	22	protein	protein	ADJ
ajst-25616	24	23	effector	effector	NOUN
ajst-25616	24	24	complex	complex	NOUN
ajst-25616	24	25	for	for	ADP
ajst-25616	24	26	coordinated	coordinated	ADJ
ajst-25616	24	27	work	work	NOUN
ajst-25616	24	28	,	,	PUNCT
ajst-25616	24	29	accounting	account	VERB
ajst-25616	24	30	for	for	ADP
ajst-25616	24	31	90	90	NUM
ajst-25616	24	32	%	%	NOUN
ajst-25616	24	33	of	of	ADP
ajst-25616	24	34	known	know	VERB
ajst-25616	24	35	crispr	crispr	ADJ
ajst-25616	24	36	types	type	NOUN
ajst-25616	24	37	and	and	CCONJ
ajst-25616	24	38	widely	widely	ADV
ajst-25616	24	39	present	present	ADJ
ajst-25616	24	40	in	in	ADP
ajst-25616	24	41	bacteria	bacteria	NOUN
ajst-25616	24	42	and	and	CCONJ
ajst-25616	24	43	archaea	archaea	NOUN
ajst-25616	24	44	.	.	PUNCT
ajst-25616	25	1	class	class	NOUN
ajst-25616	25	2	ii	ii	PROPN
ajst-25616	25	3	systems	system	NOUN
ajst-25616	25	4	are	be	AUX
ajst-25616	25	5	characterized	characterize	VERB
ajst-25616	25	6	by	by	ADP
ajst-25616	25	7	the	the	DET
ajst-25616	25	8	usage	usage	NOUN
ajst-25616	25	9	of	of	ADP
ajst-25616	25	10	a	a	DET
ajst-25616	25	11	single	single	ADJ
ajst-25616	25	12	cas	cas	NOUN
ajst-25616	25	13	protein	protein	NOUN
ajst-25616	25	14	to	to	PART
ajst-25616	25	15	perform	perform	VERB
ajst-25616	25	16	the	the	DET
ajst-25616	25	17	cut	cut	NOUN
ajst-25616	25	18	,	,	PUNCT
ajst-25616	25	19	including	include	VERB
ajst-25616	25	20	types	type	NOUN
ajst-25616	25	21	ii	ii	PROPN
ajst-25616	25	22	,	,	PUNCT
ajst-25616	25	23	v	v	NOUN
ajst-25616	25	24	,	,	PUNCT
ajst-25616	25	25	and	and	CCONJ
ajst-25616	25	26	vi	vi	NOUN
ajst-25616	25	27	,	,	PUNCT
ajst-25616	25	28	which	which	PRON
ajst-25616	25	29	make	make	VERB
ajst-25616	25	30	up	up	ADP
ajst-25616	25	31	10	10	NUM
ajst-25616	25	32	%	%	NOUN
ajst-25616	25	33	of	of	ADP
ajst-25616	25	34	known	know	VERB
ajst-25616	25	35	types	type	NOUN
ajst-25616	25	36	and	and	CCONJ
ajst-25616	25	37	are	be	AUX
ajst-25616	25	38	preferred	prefer	VERB
ajst-25616	25	39	for	for	ADP
ajst-25616	25	40	biotechnological	biotechnological	ADJ
ajst-25616	25	41	applications	application	NOUN
ajst-25616	25	42	due	due	ADP
ajst-25616	25	43	to	to	ADP
ajst-25616	25	44	their	their	PRON
ajst-25616	25	45	simplicity	simplicity	NOUN
ajst-25616	25	46	and	and	CCONJ
ajst-25616	25	47	thorough	thorough	ADJ
ajst-25616	25	48	research	research	NOUN
ajst-25616	25	49	.	.	PUNCT
ajst-25616	26	1	among	among	ADP
ajst-25616	26	2	them	they	PRON
ajst-25616	26	3	,	,	PUNCT
ajst-25616	26	4	cas9	cas9	NOUN
ajst-25616	26	5	from	from	ADP
ajst-25616	26	6	streptococcus	streptococcus	NOUN
ajst-25616	26	7	pyogenes	pyogene	NOUN
ajst-25616	26	8	(	(	PUNCT
ajst-25616	26	9	s.	s.	PROPN
ajst-25616	26	10	pyogenes	pyogenes	PROPN
ajst-25616	26	11	cas9	cas9	PROPN
ajst-25616	26	12	,	,	PUNCT
ajst-25616	26	13	spcas9	spcas9	PROPN
ajst-25616	26	14	)	)	PUNCT
ajst-25616	26	15	is	be	AUX
ajst-25616	26	16	widely	widely	ADV
ajst-25616	26	17	applied	apply	VERB
ajst-25616	26	18	in	in	ADP
ajst-25616	26	19	the	the	DET
ajst-25616	26	20	realm	realm	NOUN
ajst-25616	26	21	of	of	ADP
ajst-25616	26	22	gene	gene	NOUN
ajst-25616	26	23	editing	edit	VERB
ajst-25616	26	24	due	due	ADP
ajst-25616	26	25	to	to	ADP
ajst-25616	26	26	its	its	PRON
ajst-25616	26	27	simple	simple	ADJ
ajst-25616	26	28	and	and	CCONJ
ajst-25616	26	29	rapid	rapid	ADJ
ajst-25616	26	30	characteristics	characteristic	NOUN
ajst-25616	26	31	.	.	PUNCT
ajst-25616	27	1	this	this	DET
ajst-25616	27	2	system	system	NOUN
ajst-25616	27	3	is	be	AUX
ajst-25616	27	4	guided	guide	VERB
ajst-25616	27	5	by	by	ADP
ajst-25616	27	6	a	a	DET
ajst-25616	27	7	dual	dual	ADJ
ajst-25616	27	8	rna	rna	NOUN
ajst-25616	27	9	,	,	PUNCT
ajst-25616	27	10	including	include	VERB
ajst-25616	27	11	the	the	DET
ajst-25616	27	12	tracrrna	tracrrna	NOUN
ajst-25616	27	13	that	that	PRON
ajst-25616	27	14	targets	target	VERB
ajst-25616	27	15	dna	dna	NOUN
ajst-25616	27	16	and	and	CCONJ
ajst-25616	27	17	the	the	DET
ajst-25616	27	18	crrna	crrna	NOUN
ajst-25616	27	19	that	that	PRON
ajst-25616	27	20	forms	form	VERB
ajst-25616	27	21	a	a	DET
ajst-25616	27	22	complex	complex	NOUN
ajst-25616	27	23	with	with	ADP
ajst-25616	27	24	cas9	cas9	NOUN
ajst-25616	27	25	,	,	PUNCT
ajst-25616	27	26	with	with	ADP
ajst-25616	27	27	its	its	PRON
ajst-25616	27	28	recognition	recognition	NOUN
ajst-25616	27	29	of	of	ADP
ajst-25616	27	30	the	the	DET
ajst-25616	27	31	ngg	ngg	PROPN
ajst-25616	27	32	pam	pam	NOUN
ajst-25616	27	33	sequence	sequence	NOUN
ajst-25616	27	34	facilitating	facilitate	VERB
ajst-25616	27	35	its	its	PRON
ajst-25616	27	36	rapid	rapid	ADJ
ajst-25616	27	37	development	development	NOUN
ajst-25616	27	38	.	.	PUNCT
ajst-25616	28	1	in	in	ADP
ajst-25616	28	2	addition	addition	NOUN
ajst-25616	28	3	,	,	PUNCT
ajst-25616	28	4	researchers	researcher	NOUN
ajst-25616	28	5	are	be	AUX
ajst-25616	28	6	also	also	ADV
ajst-25616	28	7	exploring	explore	VERB
ajst-25616	28	8	other	other	ADJ
ajst-25616	28	9	crispr	crispr	ADJ
ajst-25616	28	10	systems	system	NOUN
ajst-25616	28	11	with	with	ADP
ajst-25616	28	12	different	different	ADJ
ajst-25616	28	13	characteristics	characteristic	NOUN
ajst-25616	28	14	,	,	PUNCT
ajst-25616	28	15	such	such	ADJ
ajst-25616	28	16	as	as	ADP
ajst-25616	28	17	cas12	cas12	NOUN
ajst-25616	28	18	and	and	CCONJ
ajst-25616	28	19	cas13	cas13	PROPN
ajst-25616	28	20	,	,	PUNCT
ajst-25616	28	21	as	as	ADV
ajst-25616	28	22	well	well	ADV
ajst-25616	28	23	as	as	ADP
ajst-25616	28	24	more	more	ADJ
ajst-25616	28	25	than	than	ADP
ajst-25616	28	26	70	70	NUM
ajst-25616	28	27	cas9	cas9	NOUN
ajst-25616	28	28	homologs	homolog	NOUN
ajst-25616	28	29	,	,	PUNCT
ajst-25616	28	30	which	which	PRON
ajst-25616	28	31	provide	provide	VERB
ajst-25616	28	32	different	different	ADJ
ajst-25616	28	33	pam	pam	NOUN
ajst-25616	28	34	sequence	sequence	NOUN
ajst-25616	28	35	recognition	recognition	NOUN
ajst-25616	28	36	and	and	CCONJ
ajst-25616	28	37	target	target	NOUN
ajst-25616	28	38	selection	selection	NOUN
ajst-25616	28	39	,	,	PUNCT
ajst-25616	28	40	either	either	CCONJ
ajst-25616	28	41	enhancing	enhance	VERB
ajst-25616	28	42	the	the	DET
ajst-25616	28	43	range	range	NOUN
ajst-25616	28	44	of	of	ADP
ajst-25616	28	45	sequence	sequence	NOUN
ajst-25616	28	46	recognition	recognition	NOUN
ajst-25616	28	47	or	or	CCONJ
ajst-25616	28	48	improving	improve	VERB
ajst-25616	28	49	the	the	DET
ajst-25616	28	50	efficiency	efficiency	NOUN
ajst-25616	28	51	of	of	ADP
ajst-25616	28	52	gene	gene	NOUN
ajst-25616	28	53	editing	editing	NOUN
ajst-25616	28	54	.	.	PUNCT
ajst-25616	29	1	in	in	ADP
ajst-25616	29	2	summary	summary	NOUN
ajst-25616	29	3	,	,	PUNCT
ajst-25616	29	4	they	they	PRON
ajst-25616	29	5	have	have	AUX
ajst-25616	29	6	enriched	enrich	VERB
ajst-25616	29	7	the	the	DET
ajst-25616	29	8	gene	gene	NOUN
ajst-25616	29	9	editing	edit	VERB
ajst-25616	29	10	toolkit	toolkit	NOUN
ajst-25616	29	11	[	[	X
ajst-25616	29	12	3	3	NUM
ajst-25616	29	13	]	]	PUNCT
ajst-25616	29	14	.	.	PUNCT
ajst-25616	30	1	185	185	NUM
ajst-25616	30	2	2.2	2.2	NUM
ajst-25616	30	3	.	.	PUNCT
ajst-25616	31	1	the	the	DET
ajst-25616	31	2	working	work	VERB
ajst-25616	31	3	principle	principle	NOUN
ajst-25616	31	4	of	of	ADP
ajst-25616	31	5	the	the	DET
ajst-25616	31	6	crispr	crispr	ADJ
ajst-25616	31	7	/	/	SYM
ajst-25616	31	8	cas	cas	PROPN
ajst-25616	31	9	gene	gene	NOUN
ajst-25616	31	10	editing	edit	VERB
ajst-25616	31	11	tool	tool	NOUN
ajst-25616	31	12	the	the	DET
ajst-25616	31	13	crispr	crispr	ADJ
ajst-25616	31	14	/	/	SYM
ajst-25616	31	15	cas	cas	NOUN
ajst-25616	31	16	system	system	NOUN
ajst-25616	31	17	,	,	PUNCT
ajst-25616	31	18	an	an	DET
ajst-25616	31	19	acquired	acquire	VERB
ajst-25616	31	20	bacterial	bacterial	ADJ
ajst-25616	31	21	and	and	CCONJ
ajst-25616	31	22	archaeal	archaeal	ADJ
ajst-25616	31	23	-	-	PUNCT
ajst-25616	31	24	originated	originate	VERB
ajst-25616	31	25	adaptive	adaptive	ADJ
ajst-25616	31	26	immune	immune	ADJ
ajst-25616	31	27	system	system	NOUN
ajst-25616	31	28	,	,	PUNCT
ajst-25616	31	29	consists	consist	VERB
ajst-25616	31	30	of	of	ADP
ajst-25616	31	31	crispr	crispr	ADJ
ajst-25616	31	32	rna	rna	NOUN
ajst-25616	31	33	(	(	PUNCT
ajst-25616	31	34	crrna	crrna	NOUN
ajst-25616	31	35	)	)	PUNCT
ajst-25616	31	36	and	and	CCONJ
ajst-25616	31	37	cas	cas	PROPN
ajst-25616	31	38	proteins	protein	NOUN
ajst-25616	31	39	.	.	PUNCT
ajst-25616	32	1	resist	resist	VERB
ajst-25616	32	2	foreign	foreign	ADJ
ajst-25616	32	3	dna	dna	PROPN
ajst-25616	32	4	such	such	ADJ
ajst-25616	32	5	as	as	ADP
ajst-25616	32	6	viruses	virus	NOUN
ajst-25616	32	7	or	or	CCONJ
ajst-25616	32	8	plasmids	plasmid	NOUN
ajst-25616	32	9	by	by	ADP
ajst-25616	32	10	forming	form	VERB
ajst-25616	32	11	specific	specific	ADJ
ajst-25616	32	12	effector	effector	NOUN
ajst-25616	32	13	complexes	complex	NOUN
ajst-25616	32	14	.	.	PUNCT
ajst-25616	33	1	among	among	ADP
ajst-25616	33	2	them	they	PRON
ajst-25616	33	3	,	,	PUNCT
ajst-25616	33	4	the	the	DET
ajst-25616	33	5	crispr	crispr	ADJ
ajst-25616	33	6	/	/	SYM
ajst-25616	33	7	cas9	cas9	NOUN
ajst-25616	33	8	system	system	NOUN
ajst-25616	33	9	,	,	PUNCT
ajst-25616	33	10	which	which	PRON
ajst-25616	33	11	includes	include	VERB
ajst-25616	33	12	crrna	crrna	NOUN
ajst-25616	33	13	,	,	PUNCT
ajst-25616	33	14	transactivating	transactivating	NOUN
ajst-25616	33	15	crrna	crrna	NOUN
ajst-25616	33	16	(	(	PUNCT
ajst-25616	33	17	tracrrna	tracrrna	NOUN
ajst-25616	33	18	)	)	PUNCT
ajst-25616	33	19	,	,	PUNCT
ajst-25616	33	20	and	and	CCONJ
ajst-25616	33	21	cas9	cas9	NOUN
ajst-25616	33	22	proteins	protein	NOUN
ajst-25616	33	23	,	,	PUNCT
ajst-25616	33	24	has	have	AUX
ajst-25616	33	25	been	be	AUX
ajst-25616	33	26	widely	widely	ADV
ajst-25616	33	27	used	use	VERB
ajst-25616	33	28	in	in	ADP
ajst-25616	33	29	genome	genome	NOUN
ajst-25616	33	30	editing	editing	NOUN
ajst-25616	33	31	.	.	PUNCT
ajst-25616	34	1	crrna	crrna	NOUN
ajst-25616	34	2	can	can	AUX
ajst-25616	34	3	specifically	specifically	ADV
ajst-25616	34	4	identify	identify	VERB
ajst-25616	34	5	target	target	NOUN
ajst-25616	34	6	sites	site	NOUN
ajst-25616	34	7	on	on	ADP
ajst-25616	34	8	the	the	DET
ajst-25616	34	9	genome	genome	NOUN
ajst-25616	34	10	through	through	ADP
ajst-25616	34	11	complementary	complementary	ADJ
ajst-25616	34	12	base	base	NOUN
ajst-25616	34	13	pairing	pairing	NOUN
ajst-25616	34	14	,	,	PUNCT
ajst-25616	34	15	and	and	CCONJ
ajst-25616	34	16	cooperate	cooperate	VERB
ajst-25616	34	17	with	with	ADP
ajst-25616	34	18	tracrrna	tracrrna	NOUN
ajst-25616	34	19	to	to	PART
ajst-25616	34	20	recruit	recruit	VERB
ajst-25616	34	21	cas9	cas9	NOUN
ajst-25616	34	22	protein	protein	NOUN
ajst-25616	34	23	.	.	PUNCT
ajst-25616	35	1	in	in	ADP
ajst-25616	35	2	subsequent	subsequent	ADJ
ajst-25616	35	3	studies	study	NOUN
ajst-25616	35	4	,	,	PUNCT
ajst-25616	35	5	the	the	DET
ajst-25616	35	6	scientists	scientist	NOUN
ajst-25616	35	7	simplified	simplify	VERB
ajst-25616	35	8	the	the	DET
ajst-25616	35	9	technique	technique	NOUN
ajst-25616	35	10	by	by	ADP
ajst-25616	35	11	fusing	fuse	VERB
ajst-25616	35	12	crrna	crrna	NOUN
ajst-25616	35	13	and	and	CCONJ
ajst-25616	35	14	tracrrna	tracrrna	VERB
ajst-25616	35	15	into	into	ADP
ajst-25616	35	16	a	a	DET
ajst-25616	35	17	single	single	ADJ
ajst-25616	35	18	guide	guide	NOUN
ajst-25616	35	19	rna	rna	NOUN
ajst-25616	35	20	(	(	PUNCT
ajst-25616	35	21	sgrna	sgrna	PROPN
ajst-25616	35	22	)	)	PUNCT
ajst-25616	36	1	[	[	X
ajst-25616	36	2	4	4	NUM
ajst-25616	36	3	]	]	PUNCT
ajst-25616	36	4	.	.	PUNCT
ajst-25616	37	1	the	the	DET
ajst-25616	37	2	activity	activity	NOUN
ajst-25616	37	3	of	of	ADP
ajst-25616	37	4	cas9	cas9	NOUN
ajst-25616	37	5	is	be	AUX
ajst-25616	37	6	also	also	ADV
ajst-25616	37	7	regulated	regulate	VERB
ajst-25616	37	8	by	by	ADP
ajst-25616	37	9	protospacer	protospacer	NOUN
ajst-25616	37	10	-	-	PUNCT
ajst-25616	37	11	adjacent	adjacent	ADJ
ajst-25616	37	12	motif	motif	NOUN
ajst-25616	37	13	,	,	PUNCT
ajst-25616	37	14	pam	pam	NOUN
ajst-25616	37	15	.	.	PUNCT
ajst-25616	38	1	after	after	SCONJ
ajst-25616	38	2	the	the	DET
ajst-25616	38	3	cas9	cas9	NOUN
ajst-25616	38	4	protein	protein	NOUN
ajst-25616	38	5	scans	scan	VERB
ajst-25616	38	6	the	the	DET
ajst-25616	38	7	sequence	sequence	NOUN
ajst-25616	38	8	,	,	PUNCT
ajst-25616	38	9	crrna	crrna	NOUN
ajst-25616	38	10	-	-	PUNCT
ajst-25616	38	11	specific	specific	ADJ
ajst-25616	38	12	binding	binding	NOUN
ajst-25616	38	13	to	to	ADP
ajst-25616	38	14	the	the	DET
ajst-25616	38	15	target	target	NOUN
ajst-25616	38	16	site	site	NOUN
ajst-25616	38	17	is	be	AUX
ajst-25616	38	18	required	require	VERB
ajst-25616	38	19	to	to	PART
ajst-25616	38	20	create	create	VERB
ajst-25616	38	21	double	double	ADJ
ajst-25616	38	22	-	-	PUNCT
ajst-25616	38	23	strand	strand	NOUN
ajst-25616	38	24	breaks	break	NOUN
ajst-25616	38	25	(	(	PUNCT
ajst-25616	38	26	dsbs	dsbs	ADJ
ajst-25616	38	27	)	)	PUNCT
ajst-25616	38	28	,	,	PUNCT
ajst-25616	38	29	allowing	allow	VERB
ajst-25616	38	30	the	the	DET
ajst-25616	38	31	target	target	NOUN
ajst-25616	38	32	gene	gene	NOUN
ajst-25616	38	33	to	to	PART
ajst-25616	38	34	complete	complete	VERB
ajst-25616	38	35	cut	cut	NOUN
ajst-25616	38	36	.	.	PUNCT
ajst-25616	39	1	after	after	ADP
ajst-25616	39	2	cutting	cut	VERB
ajst-25616	39	3	,	,	PUNCT
ajst-25616	39	4	cells	cell	NOUN
ajst-25616	39	5	use	use	VERB
ajst-25616	39	6	endogenous	endogenous	ADJ
ajst-25616	39	7	repair	repair	NOUN
ajst-25616	39	8	mechanisms	mechanism	NOUN
ajst-25616	39	9	to	to	PART
ajst-25616	39	10	repair	repair	VERB
ajst-25616	39	11	dsbs	dsbs	ADJ
ajst-25616	39	12	,	,	PUNCT
ajst-25616	39	13	completing	complete	VERB
ajst-25616	39	14	insertion	insertion	NOUN
ajst-25616	39	15	,	,	PUNCT
ajst-25616	39	16	deletion	deletion	NOUN
ajst-25616	39	17	,	,	PUNCT
ajst-25616	39	18	or	or	CCONJ
ajst-25616	39	19	base	base	NOUN
ajst-25616	39	20	replacement	replacement	NOUN
ajst-25616	39	21	.	.	PUNCT
ajst-25616	40	1	the	the	DET
ajst-25616	40	2	major	major	ADJ
ajst-25616	40	3	mechanisms	mechanism	NOUN
ajst-25616	40	4	include	include	VERB
ajst-25616	40	5	nonhomologous	nonhomologous	ADJ
ajst-25616	40	6	end	end	NOUN
ajst-25616	40	7	joining	join	VERB
ajst-25616	40	8	(	(	PUNCT
ajst-25616	40	9	nhej	nhej	ADJ
ajst-25616	40	10	)	)	PUNCT
ajst-25616	40	11	and	and	CCONJ
ajst-25616	40	12	homology	homology	NOUN
ajst-25616	40	13	directed	direct	VERB
ajst-25616	40	14	repair	repair	NOUN
ajst-25616	40	15	(	(	PUNCT
ajst-25616	40	16	hdr	hdr	NOUN
ajst-25616	40	17	)	)	PUNCT
ajst-25616	40	18	,	,	PUNCT
ajst-25616	40	19	which	which	PRON
ajst-25616	40	20	usually	usually	ADV
ajst-25616	40	21	result	result	VERB
ajst-25616	40	22	in	in	ADP
ajst-25616	40	23	random	random	ADJ
ajst-25616	40	24	insertion	insertion	NOUN
ajst-25616	40	25	or	or	CCONJ
ajst-25616	40	26	deletion	deletion	NOUN
ajst-25616	40	27	of	of	ADP
ajst-25616	40	28	nucleotides	nucleotide	NOUN
ajst-25616	40	29	silencing	silence	VERB
ajst-25616	40	30	genes	gene	NOUN
ajst-25616	40	31	or	or	CCONJ
ajst-25616	40	32	targeted	target	VERB
ajst-25616	40	33	disruption	disruption	NOUN
ajst-25616	40	34	of	of	ADP
ajst-25616	40	35	regulatory	regulatory	ADJ
ajst-25616	40	36	elements	element	NOUN
ajst-25616	40	37	silencing	silence	VERB
ajst-25616	40	38	downstream	downstream	ADJ
ajst-25616	40	39	genes	gene	NOUN
ajst-25616	40	40	and	and	CCONJ
ajst-25616	40	41	the	the	DET
ajst-25616	40	42	latter	latter	ADJ
ajst-25616	40	43	allows	allow	VERB
ajst-25616	40	44	precise	precise	ADJ
ajst-25616	40	45	gene	gene	NOUN
ajst-25616	40	46	editing	edit	VERB
ajst-25616	40	47	by	by	ADP
ajst-25616	40	48	inserting	insert	VERB
ajst-25616	40	49	foreign	foreign	ADJ
ajst-25616	40	50	dna	dna	NOUN
ajst-25616	40	51	sequences	sequence	NOUN
ajst-25616	41	1	[	[	X
ajst-25616	41	2	2	2	NUM
ajst-25616	41	3	]	]	PUNCT
ajst-25616	41	4	.	.	PUNCT
ajst-25616	42	1	unlike	unlike	ADP
ajst-25616	42	2	cas9	cas9	NOUN
ajst-25616	42	3	,	,	PUNCT
ajst-25616	42	4	which	which	PRON
ajst-25616	42	5	requires	require	VERB
ajst-25616	42	6	two	two	NUM
ajst-25616	42	7	separate	separate	ADJ
ajst-25616	42	8	short	short	ADJ
ajst-25616	42	9	rnas	rna	NOUN
ajst-25616	42	10	,	,	PUNCT
ajst-25616	42	11	the	the	DET
ajst-25616	42	12	cas12a	cas12a	ADJ
ajst-25616	42	13	and	and	CCONJ
ajst-25616	42	14	cas13	cas13	ADJ
ajst-25616	42	15	proteins	protein	NOUN
ajst-25616	42	16	use	use	VERB
ajst-25616	42	17	only	only	ADV
ajst-25616	42	18	one	one	NUM
ajst-25616	42	19	grna	grna	NOUN
ajst-25616	42	20	and	and	CCONJ
ajst-25616	42	21	cut	cut	VERB
ajst-25616	42	22	at	at	ADP
ajst-25616	42	23	the	the	DET
ajst-25616	42	24	target	target	NOUN
ajst-25616	42	25	dna	dna	PROPN
ajst-25616	42	26	site	site	NOUN
ajst-25616	42	27	to	to	PART
ajst-25616	42	28	form	form	VERB
ajst-25616	42	29	sticky	sticky	ADJ
ajst-25616	42	30	ends	end	NOUN
ajst-25616	42	31	,	,	PUNCT
ajst-25616	42	32	rather	rather	ADV
ajst-25616	42	33	than	than	ADP
ajst-25616	42	34	producing	produce	VERB
ajst-25616	42	35	flat	flat	ADJ
ajst-25616	42	36	ends	end	NOUN
ajst-25616	42	37	as	as	SCONJ
ajst-25616	42	38	cas9	cas9	PROPN
ajst-25616	42	39	does	do	VERB
ajst-25616	42	40	[	[	X
ajst-25616	42	41	3	3	NUM
ajst-25616	42	42	]	]	PUNCT
ajst-25616	42	43	.	.	PUNCT
ajst-25616	43	1	3	3	X
ajst-25616	43	2	.	.	X
ajst-25616	43	3	third	third	ADJ
ajst-25616	43	4	generation	generation	NOUN
ajst-25616	43	5	sequencing	sequence	VERB
ajst-25616	43	6	technology	technology	NOUN
ajst-25616	43	7	third	third	ADJ
ajst-25616	43	8	-	-	PUNCT
ajst-25616	43	9	generation	generation	NOUN
ajst-25616	43	10	sequencing	sequence	VERB
ajst-25616	43	11	technology	technology	NOUN
ajst-25616	43	12	,	,	PUNCT
ajst-25616	43	13	also	also	ADV
ajst-25616	43	14	known	know	VERB
ajst-25616	43	15	as	as	ADP
ajst-25616	43	16	single	single	ADJ
ajst-25616	43	17	-	-	PUNCT
ajst-25616	43	18	molecule	molecule	NOUN
ajst-25616	43	19	sequencing	sequencing	NOUN
ajst-25616	43	20	,	,	PUNCT
ajst-25616	43	21	represents	represent	VERB
ajst-25616	43	22	a	a	DET
ajst-25616	43	23	significant	significant	ADJ
ajst-25616	43	24	breakthrough	breakthrough	NOUN
ajst-25616	43	25	in	in	ADP
ajst-25616	43	26	genomics	genomics	NOUN
ajst-25616	43	27	research	research	NOUN
ajst-25616	43	28	.	.	PUNCT
ajst-25616	44	1	this	this	DET
ajst-25616	44	2	innovation	innovation	NOUN
ajst-25616	44	3	enables	enable	VERB
ajst-25616	44	4	the	the	DET
ajst-25616	44	5	simultaneous	simultaneous	ADJ
ajst-25616	44	6	sequencing	sequencing	NOUN
ajst-25616	44	7	of	of	ADP
ajst-25616	44	8	individual	individual	ADJ
ajst-25616	44	9	dna	dna	NOUN
ajst-25616	44	10	molecules	molecule	NOUN
ajst-25616	44	11	in	in	ADP
ajst-25616	44	12	real	real	ADJ
ajst-25616	44	13	time	time	NOUN
ajst-25616	44	14	,	,	PUNCT
ajst-25616	44	15	by	by	ADP
ajst-25616	44	16	passing	pass	VERB
ajst-25616	44	17	the	the	DET
ajst-25616	44	18	requirement	requirement	NOUN
ajst-25616	44	19	for	for	ADP
ajst-25616	44	20	pcr	pcr	ADJ
ajst-25616	44	21	amplification	amplification	NOUN
ajst-25616	44	22	.	.	PUNCT
ajst-25616	45	1	it	it	PRON
ajst-25616	45	2	is	be	AUX
ajst-25616	45	3	characterized	characterize	VERB
ajst-25616	45	4	by	by	ADP
ajst-25616	45	5	high	high	ADJ
ajst-25616	45	6	read	read	NOUN
ajst-25616	45	7	length	length	NOUN
ajst-25616	45	8	and	and	CCONJ
ajst-25616	45	9	real	real	ADJ
ajst-25616	45	10	-	-	PUNCT
ajst-25616	45	11	time	time	NOUN
ajst-25616	45	12	data	datum	NOUN
ajst-25616	45	13	output	output	NOUN
ajst-25616	45	14	,	,	PUNCT
ajst-25616	45	15	providing	provide	VERB
ajst-25616	45	16	a	a	DET
ajst-25616	45	17	more	more	ADV
ajst-25616	45	18	complete	complete	ADJ
ajst-25616	45	19	view	view	NOUN
ajst-25616	45	20	of	of	ADP
ajst-25616	45	21	the	the	DET
ajst-25616	45	22	genome	genome	NOUN
ajst-25616	45	23	and	and	CCONJ
ajst-25616	45	24	more	more	ADV
ajst-25616	45	25	accurate	accurate	ADJ
ajst-25616	45	26	detection	detection	NOUN
ajst-25616	45	27	of	of	ADP
ajst-25616	45	28	structural	structural	ADJ
ajst-25616	45	29	variations	variation	NOUN
ajst-25616	45	30	.	.	PUNCT
ajst-25616	46	1	the	the	DET
ajst-25616	46	2	main	main	ADJ
ajst-25616	46	3	third	third	ADJ
ajst-25616	46	4	-	-	PUNCT
ajst-25616	46	5	generation	generation	NOUN
ajst-25616	46	6	sequencing	sequence	VERB
ajst-25616	46	7	platforms	platform	NOUN
ajst-25616	46	8	currently	currently	ADV
ajst-25616	46	9	available	available	ADJ
ajst-25616	46	10	on	on	ADP
ajst-25616	46	11	the	the	DET
ajst-25616	46	12	market	market	NOUN
ajst-25616	46	13	include	include	VERB
ajst-25616	46	14	pacbio	pacbio	NOUN
ajst-25616	46	15	's	's	PART
ajst-25616	46	16	smrt	smrt	NOUN
ajst-25616	46	17	technology	technology	NOUN
ajst-25616	46	18	and	and	CCONJ
ajst-25616	46	19	oxford	oxford	PROPN
ajst-25616	46	20	nanopore	nanopore	ADJ
ajst-25616	46	21	technologies	technology	NOUN
ajst-25616	46	22	'	'	PART
ajst-25616	46	23	nanopore	nanopore	ADV
ajst-25616	46	24	sequencing	sequence	VERB
ajst-25616	46	25	technology	technology	NOUN
ajst-25616	46	26	.	.	PUNCT
ajst-25616	47	1	these	these	DET
ajst-25616	47	2	platforms	platform	NOUN
ajst-25616	47	3	'	'	PART
ajst-25616	47	4	high	high	ADJ
ajst-25616	47	5	throughput	throughput	NOUN
ajst-25616	47	6	and	and	CCONJ
ajst-25616	47	7	long	long	ADV
ajst-25616	47	8	read	read	VERB
ajst-25616	47	9	capabilities	capability	NOUN
ajst-25616	47	10	give	give	VERB
ajst-25616	47	11	them	they	PRON
ajst-25616	47	12	unique	unique	ADJ
ajst-25616	47	13	advantages	advantage	NOUN
ajst-25616	47	14	in	in	ADP
ajst-25616	47	15	genome	genome	NOUN
ajst-25616	47	16	assembly	assembly	NOUN
ajst-25616	47	17	,	,	PUNCT
ajst-25616	47	18	the	the	DET
ajst-25616	47	19	resolution	resolution	NOUN
ajst-25616	47	20	of	of	ADP
ajst-25616	47	21	complex	complex	ADJ
ajst-25616	47	22	genomic	genomic	ADJ
ajst-25616	47	23	regions	region	NOUN
ajst-25616	47	24	,	,	PUNCT
ajst-25616	47	25	and	and	CCONJ
ajst-25616	47	26	metagenomics	metagenomics	NOUN
ajst-25616	47	27	research	research	NOUN
ajst-25616	47	28	.	.	PUNCT
ajst-25616	48	1	with	with	ADP
ajst-25616	48	2	the	the	DET
ajst-25616	48	3	continuous	continuous	ADJ
ajst-25616	48	4	advancement	advancement	NOUN
ajst-25616	48	5	of	of	ADP
ajst-25616	48	6	the	the	DET
ajst-25616	48	7	technology	technology	NOUN
ajst-25616	48	8	,	,	PUNCT
ajst-25616	48	9	third	third	ADJ
ajst-25616	48	10	-	-	PUNCT
ajst-25616	48	11	generation	generation	NOUN
ajst-25616	48	12	sequencing	sequence	VERB
ajst-25616	48	13	technology	technology	NOUN
ajst-25616	48	14	is	be	AUX
ajst-25616	48	15	expected	expect	VERB
ajst-25616	48	16	to	to	PART
ajst-25616	48	17	play	play	VERB
ajst-25616	48	18	a	a	DET
ajst-25616	48	19	more	more	ADV
ajst-25616	48	20	critical	critical	ADJ
ajst-25616	48	21	role	role	NOUN
ajst-25616	48	22	in	in	ADP
ajst-25616	48	23	future	future	ADJ
ajst-25616	48	24	biomedical	biomedical	ADJ
ajst-25616	48	25	research	research	NOUN
ajst-25616	48	26	and	and	CCONJ
ajst-25616	48	27	clinical	clinical	ADJ
ajst-25616	48	28	diagnostics	diagnostic	NOUN
ajst-25616	48	29	.	.	PUNCT
ajst-25616	49	1	3.1	3.1	NUM
ajst-25616	49	2	.	.	PUNCT
ajst-25616	49	3	smrt	smrt	PROPN
ajst-25616	49	4	technology	technology	NOUN
ajst-25616	49	5	at	at	ADP
ajst-25616	49	6	present	present	ADJ
ajst-25616	49	7	,	,	PUNCT
ajst-25616	49	8	single	single	ADJ
ajst-25616	49	9	molecule	molecule	NOUN
ajst-25616	49	10	real	real	ADJ
ajst-25616	49	11	-	-	PUNCT
ajst-25616	49	12	time	time	NOUN
ajst-25616	49	13	(	(	PUNCT
ajst-25616	49	14	smrt	smrt	NOUN
ajst-25616	49	15	)	)	PUNCT
ajst-25616	49	16	sequencing	sequencing	NOUN
ajst-25616	49	17	,	,	PUNCT
ajst-25616	49	18	developed	develop	VERB
ajst-25616	49	19	by	by	ADP
ajst-25616	49	20	pacific	pacific	PROPN
ajst-25616	49	21	biosciences	bioscience	NOUN
ajst-25616	49	22	(	(	PUNCT
ajst-25616	49	23	referred	refer	VERB
ajst-25616	49	24	to	to	ADP
ajst-25616	49	25	as	as	ADP
ajst-25616	49	26	pacbio	pacbio	NOUN
ajst-25616	49	27	)	)	PUNCT
ajst-25616	49	28	,	,	PUNCT
ajst-25616	49	29	is	be	AUX
ajst-25616	49	30	one	one	NUM
ajst-25616	49	31	of	of	ADP
ajst-25616	49	32	the	the	DET
ajst-25616	49	33	mainstream	mainstream	ADJ
ajst-25616	49	34	third	third	ADJ
ajst-25616	49	35	-	-	PUNCT
ajst-25616	49	36	generation	generation	NOUN
ajst-25616	49	37	sequencing	sequence	VERB
ajst-25616	49	38	platforms	platform	NOUN
ajst-25616	49	39	.	.	PUNCT
ajst-25616	50	1	it	it	PRON
ajst-25616	50	2	is	be	AUX
ajst-25616	50	3	important	important	ADJ
ajst-25616	50	4	to	to	PART
ajst-25616	50	5	note	note	VERB
ajst-25616	50	6	that	that	SCONJ
ajst-25616	50	7	before	before	ADP
ajst-25616	50	8	carrying	carry	VERB
ajst-25616	50	9	out	out	ADP
ajst-25616	50	10	smrt	smrt	NOUN
ajst-25616	50	11	sequencing	sequencing	NOUN
ajst-25616	50	12	,	,	PUNCT
ajst-25616	50	13	a	a	DET
ajst-25616	50	14	library	library	NOUN
ajst-25616	50	15	must	must	AUX
ajst-25616	50	16	first	first	ADV
ajst-25616	50	17	be	be	AUX
ajst-25616	50	18	prepared	prepare	VERB
ajst-25616	50	19	from	from	ADP
ajst-25616	50	20	double	double	ADJ
ajst-25616	50	21	-	-	PUNCT
ajst-25616	50	22	stranded	strand	VERB
ajst-25616	50	23	dna	dna	NOUN
ajst-25616	50	24	.	.	PUNCT
ajst-25616	51	1	the	the	DET
ajst-25616	51	2	hairpin	hairpin	NOUN
ajst-25616	51	3	adapters	adapter	NOUN
ajst-25616	51	4	is	be	AUX
ajst-25616	51	5	connected	connect	VERB
ajst-25616	51	6	to	to	ADP
ajst-25616	51	7	the	the	DET
ajst-25616	51	8	dna	dna	PROPN
ajst-25616	51	9	molecule	molecule	NOUN
ajst-25616	51	10	to	to	PART
ajst-25616	51	11	form	form	VERB
ajst-25616	51	12	a	a	DET
ajst-25616	51	13	closed	close	VERB
ajst-25616	51	14	-	-	PUNCT
ajst-25616	51	15	loop	loop	NOUN
ajst-25616	51	16	smrtbell	smrtbell	NOUN
ajst-25616	51	17	.	.	PUNCT
ajst-25616	52	1	next	next	ADV
ajst-25616	52	2	,	,	PUNCT
ajst-25616	52	3	a	a	DET
ajst-25616	52	4	primers	primer	NOUN
ajst-25616	52	5	and	and	CCONJ
ajst-25616	52	6	a	a	DET
ajst-25616	52	7	polymerase	polymerase	NOUN
ajst-25616	52	8	are	be	AUX
ajst-25616	52	9	bound	bind	VERB
ajst-25616	52	10	to	to	ADP
ajst-25616	52	11	the	the	DET
ajst-25616	52	12	adapter	adapter	NOUN
ajst-25616	52	13	,	,	PUNCT
ajst-25616	52	14	and	and	CCONJ
ajst-25616	52	15	the	the	DET
ajst-25616	52	16	library	library	NOUN
ajst-25616	52	17	is	be	AUX
ajst-25616	52	18	loaded	load	VERB
ajst-25616	52	19	into	into	ADP
ajst-25616	52	20	an	an	DET
ajst-25616	52	21	smrt	smrt	NOUN
ajst-25616	52	22	cell	cell	NOUN
ajst-25616	52	23	containing	contain	VERB
ajst-25616	52	24	a	a	DET
ajst-25616	52	25	large	large	ADJ
ajst-25616	52	26	number	number	NOUN
ajst-25616	52	27	of	of	ADP
ajst-25616	52	28	nanoscale	nanoscale	NOUN
ajst-25616	52	29	observation	observation	NOUN
ajst-25616	52	30	chambers	chamber	NOUN
ajst-25616	52	31	(	(	PUNCT
ajst-25616	52	32	zmws	zmws	NOUN
ajst-25616	52	33	)	)	PUNCT
ajst-25616	52	34	.	.	PUNCT
ajst-25616	53	1	the	the	DET
ajst-25616	53	2	rsii	rsii	ADJ
ajst-25616	53	3	system	system	NOUN
ajst-25616	53	4	can	can	AUX
ajst-25616	53	5	load	load	VERB
ajst-25616	53	6	up	up	ADP
ajst-25616	53	7	to	to	PART
ajst-25616	53	8	150,000	150,000	NUM
ajst-25616	53	9	zmws	zmws	NOUN
ajst-25616	53	10	,	,	PUNCT
ajst-25616	53	11	while	while	SCONJ
ajst-25616	53	12	the	the	DET
ajst-25616	53	13	sequel	sequel	NOUN
ajst-25616	53	14	platform	platform	NOUN
ajst-25616	53	15	can	can	AUX
ajst-25616	53	16	load	load	VERB
ajst-25616	53	17	up	up	ADP
ajst-25616	53	18	to	to	PART
ajst-25616	53	19	1	1	NUM
ajst-25616	53	20	million[5].in	million[5].in	NOUN
ajst-25616	53	21	distinction	distinction	NOUN
ajst-25616	53	22	to	to	ADP
ajst-25616	53	23	next	next	ADJ
ajst-25616	53	24	-	-	PUNCT
ajst-25616	53	25	generation	generation	NOUN
ajst-25616	53	26	sequencing	sequencing	NOUN
ajst-25616	53	27	(	(	PUNCT
ajst-25616	53	28	ngs	ng	NOUN
ajst-25616	53	29	)	)	PUNCT
ajst-25616	53	30	techniques	technique	NOUN
ajst-25616	53	31	,	,	PUNCT
ajst-25616	53	32	single	single	ADJ
ajst-25616	53	33	molecule	molecule	NOUN
ajst-25616	53	34	real	real	ADJ
ajst-25616	53	35	-	-	PUNCT
ajst-25616	53	36	time	time	NOUN
ajst-25616	53	37	(	(	PUNCT
ajst-25616	53	38	smrt	smrt	NOUN
ajst-25616	53	39	)	)	PUNCT
ajst-25616	53	40	sequencing	sequence	VERB
ajst-25616	53	41	detects	detect	NOUN
ajst-25616	53	42	nucleotide	nucleotide	ADJ
ajst-25616	53	43	incorporation	incorporation	NOUN
ajst-25616	53	44	in	in	ADP
ajst-25616	53	45	real	real	ADJ
ajst-25616	53	46	-	-	PUNCT
ajst-25616	53	47	time	time	NOUN
ajst-25616	53	48	on	on	ADP
ajst-25616	53	49	a	a	DET
ajst-25616	53	50	per	per	ADP
ajst-25616	53	51	-	-	PUNCT
ajst-25616	53	52	molecule	molecule	NOUN
ajst-25616	53	53	basis	basis	NOUN
ajst-25616	53	54	.	.	PUNCT
ajst-25616	54	1	this	this	DET
ajst-25616	54	2	method	method	NOUN
ajst-25616	54	3	also	also	ADV
ajst-25616	54	4	leverages	leverage	VERB
ajst-25616	54	5	incorporation	incorporation	NOUN
ajst-25616	54	6	timing	timing	NOUN
ajst-25616	54	7	to	to	PART
ajst-25616	54	8	infer	infer	VERB
ajst-25616	54	9	base	base	NOUN
ajst-25616	54	10	modification	modification	NOUN
ajst-25616	54	11	profiles	profile	NOUN
ajst-25616	54	12	.	.	PUNCT
ajst-25616	55	1	to	to	PART
ajst-25616	55	2	mitigate	mitigate	VERB
ajst-25616	55	3	the	the	DET
ajst-25616	55	4	error	error	NOUN
ajst-25616	55	5	rate	rate	NOUN
ajst-25616	55	6	,	,	PUNCT
ajst-25616	55	7	pacific	pacific	ADJ
ajst-25616	55	8	biosciences	bioscience	NOUN
ajst-25616	55	9	(	(	PUNCT
ajst-25616	55	10	pacbio	pacbio	NOUN
ajst-25616	55	11	)	)	PUNCT
ajst-25616	55	12	offers	offer	VERB
ajst-25616	55	13	an	an	DET
ajst-25616	55	14	enhanced	enhance	VERB
ajst-25616	55	15	protocol	protocol	NOUN
ajst-25616	55	16	known	know	VERB
ajst-25616	55	17	as	as	ADP
ajst-25616	55	18	circular	circular	ADJ
ajst-25616	55	19	consensus	consensus	NOUN
ajst-25616	55	20	sequencing	sequence	VERB
ajst-25616	55	21	(	(	PUNCT
ajst-25616	55	22	ccs	ccs	PROPN
ajst-25616	55	23	)	)	PUNCT
ajst-25616	55	24	.	.	PUNCT
ajst-25616	56	1	the	the	DET
ajst-25616	56	2	dna	dna	PROPN
ajst-25616	56	3	templates	template	NOUN
ajst-25616	56	4	are	be	AUX
ajst-25616	56	5	circularized	circularize	VERB
ajst-25616	56	6	,	,	PUNCT
ajst-25616	56	7	allowing	allow	VERB
ajst-25616	56	8	the	the	DET
ajst-25616	56	9	polymerase	polymerase	NOUN
ajst-25616	56	10	to	to	PART
ajst-25616	56	11	read	read	VERB
ajst-25616	56	12	through	through	ADP
ajst-25616	56	13	them	they	PRON
ajst-25616	56	14	multiple	multiple	ADJ
ajst-25616	56	15	times	time	NOUN
ajst-25616	56	16	,	,	PUNCT
ajst-25616	56	17	thereby	thereby	ADV
ajst-25616	56	18	significantly	significantly	ADV
ajst-25616	56	19	improving	improve	VERB
ajst-25616	56	20	the	the	DET
ajst-25616	56	21	precision	precision	NOUN
ajst-25616	56	22	from	from	ADP
ajst-25616	56	23	around	around	ADP
ajst-25616	56	24	90	90	NUM
ajst-25616	56	25	%	%	NOUN
ajst-25616	56	26	to	to	ADP
ajst-25616	56	27	99.8%[6	99.8%[6	NUM
ajst-25616	56	28	]	]	PUNCT
ajst-25616	56	29	.	.	PUNCT
ajst-25616	57	1	due	due	ADP
ajst-25616	57	2	to	to	ADP
ajst-25616	57	3	its	its	PRON
ajst-25616	57	4	advantages	advantage	NOUN
ajst-25616	57	5	such	such	ADJ
ajst-25616	57	6	as	as	ADP
ajst-25616	57	7	ultra	ultra	ADJ
ajst-25616	57	8	-	-	ADJ
ajst-25616	57	9	long	long	ADJ
ajst-25616	57	10	read	read	NOUN
ajst-25616	57	11	length	length	NOUN
ajst-25616	57	12	,	,	PUNCT
ajst-25616	57	13	no	no	DET
ajst-25616	57	14	need	need	NOUN
ajst-25616	57	15	for	for	ADP
ajst-25616	57	16	template	template	NOUN
ajst-25616	57	17	amplification	amplification	NOUN
ajst-25616	57	18	,	,	PUNCT
ajst-25616	57	19	shorter	short	ADJ
ajst-25616	57	20	run	run	NOUN
ajst-25616	57	21	times	time	NOUN
ajst-25616	57	22	,	,	PUNCT
ajst-25616	57	23	and	and	CCONJ
ajst-25616	57	24	realtime	realtime	NOUN
ajst-25616	57	25	monitoring	monitoring	NOUN
ajst-25616	57	26	of	of	ADP
ajst-25616	57	27	epigenetic	epigenetic	ADJ
ajst-25616	57	28	modification	modification	NOUN
ajst-25616	57	29	sites	site	NOUN
ajst-25616	57	30	[	[	X
ajst-25616	57	31	7	7	NUM
ajst-25616	57	32	]	]	PUNCT
ajst-25616	57	33	,	,	PUNCT
ajst-25616	57	34	its	its	PRON
ajst-25616	57	35	use	use	NOUN
ajst-25616	57	36	is	be	AUX
ajst-25616	57	37	gaining	gain	VERB
ajst-25616	57	38	broader	broad	ADJ
ajst-25616	57	39	acceptance	acceptance	NOUN
ajst-25616	57	40	,	,	PUNCT
ajst-25616	57	41	extending	extend	VERB
ajst-25616	57	42	its	its	PRON
ajst-25616	57	43	reach	reach	NOUN
ajst-25616	57	44	beyond	beyond	ADP
ajst-25616	57	45	the	the	DET
ajst-25616	57	46	realm	realm	NOUN
ajst-25616	57	47	of	of	ADP
ajst-25616	57	48	fundamental	fundamental	ADJ
ajst-25616	57	49	science	science	NOUN
ajst-25616	57	50	to	to	PART
ajst-25616	57	51	encompass	encompass	VERB
ajst-25616	57	52	practical	practical	ADJ
ajst-25616	57	53	domains	domain	NOUN
ajst-25616	57	54	like	like	ADP
ajst-25616	57	55	agriculture	agriculture	NOUN
ajst-25616	57	56	,	,	PUNCT
ajst-25616	57	57	environmental	environmental	ADJ
ajst-25616	57	58	studies	study	NOUN
ajst-25616	57	59	,	,	PUNCT
ajst-25616	57	60	and	and	CCONJ
ajst-25616	57	61	medical	medical	ADJ
ajst-25616	57	62	investigation	investigation	NOUN
ajst-25616	57	63	.	.	PUNCT
ajst-25616	58	1	in	in	ADP
ajst-25616	58	2	basic	basic	ADJ
ajst-25616	58	3	science	science	NOUN
ajst-25616	58	4	,	,	PUNCT
ajst-25616	58	5	smrt	smrt	NOUN
ajst-25616	58	6	sequencing	sequencing	NOUN
ajst-25616	58	7	can	can	AUX
ajst-25616	58	8	study	study	VERB
ajst-25616	58	9	the	the	DET
ajst-25616	58	10	molecular	molecular	ADJ
ajst-25616	58	11	mechanisms	mechanism	NOUN
ajst-25616	58	12	of	of	ADP
ajst-25616	58	13	living	living	NOUN
ajst-25616	58	14	cells	cell	NOUN
ajst-25616	58	15	with	with	ADP
ajst-25616	58	16	new	new	ADJ
ajst-25616	58	17	resolution	resolution	NOUN
ajst-25616	58	18	[	[	X
ajst-25616	58	19	8	8	NUM
ajst-25616	58	20	]	]	PUNCT
ajst-25616	58	21	.	.	PUNCT
ajst-25616	59	1	this	this	PRON
ajst-25616	59	2	makes	make	VERB
ajst-25616	59	3	it	it	PRON
ajst-25616	59	4	possible	possible	ADJ
ajst-25616	59	5	to	to	PART
ajst-25616	59	6	construct	construct	VERB
ajst-25616	59	7	dynamic	dynamic	ADJ
ajst-25616	59	8	genomes	genome	NOUN
ajst-25616	59	9	and	and	CCONJ
ajst-25616	59	10	monitor	monitor	VERB
ajst-25616	59	11	real	real	ADJ
ajst-25616	59	12	-	-	PUNCT
ajst-25616	59	13	time	time	NOUN
ajst-25616	59	14	gene	gene	NOUN
ajst-25616	59	15	synthesis	synthesis	NOUN
ajst-25616	59	16	and	and	CCONJ
ajst-25616	59	17	origin	origin	NOUN
ajst-25616	59	18	in	in	ADP
ajst-25616	59	19	organisms	organism	NOUN
ajst-25616	59	20	.	.	PUNCT
ajst-25616	60	1	at	at	ADP
ajst-25616	60	2	the	the	DET
ajst-25616	60	3	same	same	ADJ
ajst-25616	60	4	time	time	NOUN
ajst-25616	60	5	,	,	PUNCT
ajst-25616	60	6	due	due	ADP
ajst-25616	60	7	to	to	ADP
ajst-25616	60	8	its	its	PRON
ajst-25616	60	9	pacbio	pacbio	NOUN
ajst-25616	60	10	circular	circular	ADJ
ajst-25616	60	11	consensus	consensus	NOUN
ajst-25616	60	12	sequencing	sequence	VERB
ajst-25616	60	13	(	(	PUNCT
ajst-25616	60	14	ccs	ccs	PROPN
ajst-25616	60	15	)	)	PUNCT
ajst-25616	60	16	with	with	ADP
ajst-25616	60	17	high	high	ADJ
ajst-25616	60	18	-	-	PUNCT
ajst-25616	60	19	throughput	throughput	NOUN
ajst-25616	60	20	and	and	CCONJ
ajst-25616	60	21	high	high	ADJ
ajst-25616	60	22	accuracy	accuracy	NOUN
ajst-25616	60	23	,	,	PUNCT
ajst-25616	60	24	it	it	PRON
ajst-25616	60	25	plays	play	VERB
ajst-25616	60	26	an	an	DET
ajst-25616	60	27	important	important	ADJ
ajst-25616	60	28	role	role	NOUN
ajst-25616	60	29	in	in	ADP
ajst-25616	60	30	epigenetics	epigenetic	NOUN
ajst-25616	60	31	,	,	PUNCT
ajst-25616	60	32	such	such	ADJ
ajst-25616	60	33	as	as	ADP
ajst-25616	60	34	dna	dna	PROPN
ajst-25616	60	35	methylation	methylation	NOUN
ajst-25616	60	36	modifications	modification	NOUN
ajst-25616	60	37	[	[	X
ajst-25616	60	38	9	9	NUM
ajst-25616	60	39	,	,	PUNCT
ajst-25616	60	40	10	10	NUM
ajst-25616	60	41	]	]	PUNCT
ajst-25616	60	42	,	,	PUNCT
ajst-25616	60	43	as	as	ADV
ajst-25616	60	44	well	well	ADV
ajst-25616	60	45	as	as	ADP
ajst-25616	60	46	in	in	ADP
ajst-25616	60	47	the	the	DET
ajst-25616	60	48	analysis	analysis	NOUN
ajst-25616	60	49	of	of	ADP
ajst-25616	60	50	rna	rna	NOUN
ajst-25616	60	51	isoform	isoform	NOUN
ajst-25616	60	52	sequencing	sequence	VERB
ajst-25616	60	53	[	[	X
ajst-25616	60	54	11	11	NUM
ajst-25616	60	55	]	]	SYM
ajst-25616	60	56	.	.	PUNCT
ajst-25616	61	1	3.2	3.2	NUM
ajst-25616	61	2	.	.	PUNCT
ajst-25616	62	1	nanopore	nanopore	ADJ
ajst-25616	62	2	sequencing	sequence	VERB
ajst-25616	62	3	technology	technology	NOUN
ajst-25616	62	4	oxford	oxford	ADJ
ajst-25616	62	5	nanopore	nanopore	ADJ
ajst-25616	62	6	technologies	technology	NOUN
ajst-25616	62	7	(	(	PUNCT
ajst-25616	62	8	ont	ont	NOUN
ajst-25616	62	9	)	)	PUNCT
ajst-25616	62	10	secured	secure	VERB
ajst-25616	62	11	the	the	DET
ajst-25616	62	12	licensing	licensing	NOUN
ajst-25616	62	13	rights	right	NOUN
ajst-25616	62	14	for	for	ADP
ajst-25616	62	15	its	its	PRON
ajst-25616	62	16	foundational	foundational	ADJ
ajst-25616	62	17	nanopore	nanopore	ADV
ajst-25616	62	18	sequencing	sequence	VERB
ajst-25616	62	19	patents	patent	NOUN
ajst-25616	62	20	in	in	ADP
ajst-25616	62	21	2007	2007	NUM
ajst-25616	62	22	and	and	CCONJ
ajst-25616	62	23	initiated	initiate	VERB
ajst-25616	62	24	its	its	PRON
ajst-25616	62	25	strand	strand	NOUN
ajst-25616	62	26	sequencing	sequence	VERB
ajst-25616	62	27	operations	operation	NOUN
ajst-25616	62	28	in	in	ADP
ajst-25616	62	29	2010	2010	NUM
ajst-25616	62	30	.	.	PUNCT
ajst-25616	63	1	and	and	CCONJ
ajst-25616	63	2	in	in	ADP
ajst-25616	63	3	june	june	PROPN
ajst-25616	63	4	2014	2014	NUM
ajst-25616	63	5	,	,	PUNCT
ajst-25616	63	6	oxford	oxford	PROPN
ajst-25616	63	7	nanopore	nanopore	ADJ
ajst-25616	63	8	technologies	technology	NOUN
ajst-25616	63	9	(	(	PUNCT
ajst-25616	63	10	ont	ont	NOUN
ajst-25616	63	11	)	)	PUNCT
ajst-25616	63	12	introduced	introduce	VERB
ajst-25616	63	13	individual	individual	ADJ
ajst-25616	63	14	minion	minion	NOUN
ajst-25616	63	15	devices	device	NOUN
ajst-25616	63	16	as	as	ADP
ajst-25616	63	17	part	part	NOUN
ajst-25616	63	18	of	of	ADP
ajst-25616	63	19	a	a	DET
ajst-25616	63	20	comprehensive	comprehensive	ADJ
ajst-25616	63	21	initiative	initiative	NOUN
ajst-25616	63	22	known	know	VERB
ajst-25616	63	23	as	as	ADP
ajst-25616	63	24	the	the	DET
ajst-25616	63	25	minion	minion	NOUN
ajst-25616	63	26	access	access	NOUN
ajst-25616	63	27	program	program	NOUN
ajst-25616	63	28	(	(	PUNCT
ajst-25616	63	29	map)[12	map)[12	PROPN
ajst-25616	63	30	]	]	X
ajst-25616	63	31	.	.	PUNCT
ajst-25616	64	1	nanopores	nanopore	NOUN
ajst-25616	64	2	are	be	AUX
ajst-25616	64	3	categorized	categorize	VERB
ajst-25616	64	4	into	into	ADP
ajst-25616	64	5	two	two	NUM
ajst-25616	64	6	principal	principal	ADJ
ajst-25616	64	7	classes	class	NOUN
ajst-25616	64	8	:	:	PUNCT
ajst-25616	64	9	biological	biological	ADJ
ajst-25616	64	10	and	and	CCONJ
ajst-25616	64	11	solid	solid	ADJ
ajst-25616	64	12	-	-	PUNCT
ajst-25616	64	13	state	state	NOUN
ajst-25616	64	14	.	.	PUNCT
ajst-25616	65	1	biological	biological	ADJ
ajst-25616	65	2	nanopores	nanopore	NOUN
ajst-25616	65	3	encompass	encompass	VERB
ajst-25616	65	4	entities	entity	NOUN
ajst-25616	65	5	like	like	ADP
ajst-25616	65	6	the	the	DET
ajst-25616	65	7	α	α	NOUN
ajst-25616	65	8	-	-	NOUN
ajst-25616	65	9	hemolysin	hemolysin	NOUN
ajst-25616	65	10	(	(	PUNCT
ajst-25616	65	11	α	α	NOUN
ajst-25616	65	12	-	-	PUNCT
ajst-25616	65	13	hl	hl	NOUN
ajst-25616	65	14	)	)	PUNCT
ajst-25616	65	15	pore	pore	ADJ
ajst-25616	65	16	,	,	PUNCT
ajst-25616	65	17	mycobacterium	mycobacterium	PROPN
ajst-25616	65	18	smegmatis	smegmatis	PROPN
ajst-25616	65	19	porin	porin	PROPN
ajst-25616	65	20	a	a	DET
ajst-25616	65	21	(	(	PUNCT
ajst-25616	65	22	mspa	mspa	NOUN
ajst-25616	65	23	)	)	PUNCT
ajst-25616	65	24	,	,	PUNCT
ajst-25616	65	25	and	and	CCONJ
ajst-25616	65	26	the	the	DET
ajst-25616	65	27	phi29	phi29	ADJ
ajst-25616	65	28	connector	connector	NOUN
ajst-25616	65	29	.	.	PUNCT
ajst-25616	66	1	in	in	ADP
ajst-25616	66	2	contrast	contrast	NOUN
ajst-25616	66	3	,	,	PUNCT
ajst-25616	66	4	solid	solid	ADJ
ajst-25616	66	5	-	-	PUNCT
ajst-25616	66	6	state	state	NOUN
ajst-25616	66	7	nanopores	nanopore	NOUN
ajst-25616	66	8	are	be	AUX
ajst-25616	66	9	predominantly	predominantly	ADV
ajst-25616	66	10	crafted	craft	VERB
ajst-25616	66	11	from	from	ADP
ajst-25616	66	12	silicon	silicon	NOUN
ajst-25616	66	13	-	-	PUNCT
ajst-25616	66	14	based	base	VERB
ajst-25616	66	15	substrates	substrate	NOUN
ajst-25616	66	16	,	,	PUNCT
ajst-25616	66	17	including	include	VERB
ajst-25616	66	18	silicon	silicon	NOUN
ajst-25616	66	19	and	and	CCONJ
ajst-25616	66	20	silicon	silicon	NOUN
ajst-25616	66	21	nitride	nitride	PROPN
ajst-25616	66	22	.	.	PUNCT
ajst-25616	67	1	the	the	DET
ajst-25616	67	2	field	field	NOUN
ajst-25616	67	3	has	have	AUX
ajst-25616	67	4	also	also	ADV
ajst-25616	67	5	witnessed	witness	VERB
ajst-25616	67	6	the	the	DET
ajst-25616	67	7	emergence	emergence	NOUN
ajst-25616	67	8	of	of	ADP
ajst-25616	67	9	novel	novel	ADJ
ajst-25616	67	10	materials	material	NOUN
ajst-25616	67	11	for	for	ADP
ajst-25616	67	12	nanopore	nanopore	ADJ
ajst-25616	67	13	fabrication	fabrication	NOUN
ajst-25616	67	14	in	in	ADP
ajst-25616	67	15	recent	recent	ADJ
ajst-25616	67	16	times	time	NOUN
ajst-25616	67	17	,	,	PUNCT
ajst-25616	67	18	expanding	expand	VERB
ajst-25616	67	19	the	the	DET
ajst-25616	67	20	scope	scope	NOUN
ajst-25616	67	21	of	of	ADP
ajst-25616	67	22	materials	material	NOUN
ajst-25616	67	23	science	science	NOUN
ajst-25616	67	24	in	in	ADP
ajst-25616	67	25	this	this	DET
ajst-25616	67	26	domain[13	domain[13	PROPN
ajst-25616	67	27	]	]	PUNCT
ajst-25616	67	28	.	.	PUNCT
ajst-25616	68	1	its	its	PRON
ajst-25616	68	2	core	core	NOUN
ajst-25616	68	3	is	be	AUX
ajst-25616	68	4	a	a	DET
ajst-25616	68	5	nanoscale	nanoscale	NOUN
ajst-25616	68	6	protein	protein	NOUN
ajst-25616	68	7	pore	pore	NOUN
ajst-25616	68	8	,	,	PUNCT
ajst-25616	68	9	acting	act	VERB
ajst-25616	68	10	as	as	ADP
ajst-25616	68	11	a	a	DET
ajst-25616	68	12	biosensor	biosensor	NOUN
ajst-25616	68	13	,	,	PUNCT
ajst-25616	68	14	set	set	VERB
ajst-25616	68	15	within	within	ADP
ajst-25616	68	16	an	an	DET
ajst-25616	68	17	electrically	electrically	ADV
ajst-25616	68	18	insulating	insulate	VERB
ajst-25616	68	19	polymer	polymer	NOUN
ajst-25616	68	20	membrane	membrane	NOUN
ajst-25616	68	21	.	.	PUNCT
ajst-25616	69	1	this	this	DET
ajst-25616	69	2	system	system	NOUN
ajst-25616	69	3	functions	function	NOUN
ajst-25616	69	4	by	by	ADP
ajst-25616	69	5	maintaining	maintain	VERB
ajst-25616	69	6	a	a	DET
ajst-25616	69	7	steady	steady	ADJ
ajst-25616	69	8	voltage	voltage	NOUN
ajst-25616	69	9	across	across	ADP
ajst-25616	69	10	the	the	DET
ajst-25616	69	11	nanopore	nanopore	ADV
ajst-25616	69	12	immersed	immerse	VERB
ajst-25616	69	13	in	in	ADP
ajst-25616	69	14	an	an	DET
ajst-25616	69	15	electrolytic	electrolytic	ADJ
ajst-25616	69	16	solution	solution	NOUN
ajst-25616	69	17	,	,	PUNCT
ajst-25616	69	18	propelling	propel	VERB
ajst-25616	69	19	the	the	DET
ajst-25616	69	20	negatively	negatively	ADV
ajst-25616	69	21	charged	charge	VERB
ajst-25616	69	22	single	single	ADJ
ajst-25616	69	23	-	-	PUNCT
ajst-25616	69	24	stranded	strand	VERB
ajst-25616	69	25	dna	dna	NOUN
ajst-25616	69	26	or	or	CCONJ
ajst-25616	69	27	rna	rna	NOUN
ajst-25616	69	28	molecules	molecule	NOUN
ajst-25616	69	29	through	through	ADP
ajst-25616	69	30	the	the	DET
ajst-25616	69	31	pore	pore	NOUN
ajst-25616	69	32	from	from	ADP
ajst-25616	69	33	the	the	DET
ajst-25616	69	34	negatively	negatively	ADV
ajst-25616	69	35	charged	charge	VERB
ajst-25616	69	36	'	'	PUNCT
ajst-25616	69	37	cis	cis	NOUN
ajst-25616	69	38	'	'	PUNCT
ajst-25616	69	39	compartment	compartment	NOUN
ajst-25616	69	40	to	to	ADP
ajst-25616	69	41	the	the	DET
ajst-25616	69	42	positively	positively	ADV
ajst-25616	69	43	charged	charge	VERB
ajst-25616	69	44	'	'	PUNCT
ajst-25616	69	45	trans	tran	NOUN
ajst-25616	69	46	'	'	PART
ajst-25616	69	47	compartment[14	compartment[14	PROPN
ajst-25616	69	48	]	]	X
ajst-25616	69	49	.	.	PUNCT
ajst-25616	70	1	as	as	SCONJ
ajst-25616	70	2	the	the	DET
ajst-25616	70	3	nucleic	nucleic	ADJ
ajst-25616	70	4	acid	acid	NOUN
ajst-25616	70	5	molecule	molecule	NOUN
ajst-25616	70	6	traverses	traverse	NOUN
ajst-25616	70	7	the	the	DET
ajst-25616	70	8	pore	pore	NOUN
ajst-25616	70	9	in	in	ADP
ajst-25616	70	10	a	a	DET
ajst-25616	70	11	stepwise	stepwise	ADJ
ajst-25616	70	12	fashion	fashion	NOUN
ajst-25616	70	13	,	,	PUNCT
ajst-25616	70	14	fluctuations	fluctuation	NOUN
ajst-25616	70	15	in	in	ADP
ajst-25616	70	16	the	the	DET
ajst-25616	70	17	ionic	ionic	ADJ
ajst-25616	70	18	current	current	NOUN
ajst-25616	70	19	reflect	reflect	VERB
ajst-25616	70	20	the	the	DET
ajst-25616	70	21	sequence	sequence	NOUN
ajst-25616	70	22	of	of	ADP
ajst-25616	70	23	nucleotide	nucleotide	NOUN
ajst-25616	70	24	within	within	ADP
ajst-25616	70	25	the	the	DET
ajst-25616	70	26	detection	detection	NOUN
ajst-25616	70	27	region	region	NOUN
ajst-25616	70	28	.	.	PUNCT
ajst-25616	71	1	these	these	DET
ajst-25616	71	2	changes	change	NOUN
ajst-25616	71	3	are	be	AUX
ajst-25616	71	4	captured	capture	VERB
ajst-25616	71	5	in	in	ADP
ajst-25616	71	6	real	real	ADJ
ajst-25616	71	7	-	-	PUNCT
ajst-25616	71	8	time	time	NOUN
ajst-25616	71	9	and	and	CCONJ
ajst-25616	71	10	decoded	decode	VERB
ajst-25616	71	11	by	by	ADP
ajst-25616	71	12	computational	computational	ADJ
ajst-25616	71	13	algorithms	algorithm	NOUN
ajst-25616	71	14	to	to	PART
ajst-25616	71	15	determine	determine	VERB
ajst-25616	71	16	the	the	DET
ajst-25616	71	17	genetic	genetic	ADJ
ajst-25616	71	18	sequence	sequence	NOUN
ajst-25616	71	19	of	of	ADP
ajst-25616	71	20	the	the	DET
ajst-25616	71	21	single	single	ADJ
ajst-25616	71	22	molecule	molecule	NOUN
ajst-25616	71	23	.	.	PUNCT
ajst-25616	72	1	this	this	PRON
ajst-25616	72	2	"	"	PUNCT
ajst-25616	72	3	sequencing	sequence	VERB
ajst-25616	72	4	by	by	ADP
ajst-25616	72	5	synthesis	synthesis	NOUN
ajst-25616	72	6	"	"	PUNCT
ajst-25616	72	7	approach	approach	NOUN
ajst-25616	72	8	allows	allow	VERB
ajst-25616	72	9	for	for	ADP
ajst-25616	72	10	the	the	DET
ajst-25616	72	11	real	real	ADJ
ajst-25616	72	12	-	-	PUNCT
ajst-25616	72	13	time	time	NOUN
ajst-25616	72	14	,	,	PUNCT
ajst-25616	72	15	single	single	ADJ
ajst-25616	72	16	-	-	PUNCT
ajst-25616	72	17	molecule	molecule	NOUN
ajst-25616	72	18	sequencing	sequencing	NOUN
ajst-25616	72	19	,	,	PUNCT
ajst-25616	72	20	distinguishing	distinguish	VERB
ajst-25616	72	21	ont	ont	NOUN
ajst-25616	72	22	's	's	PART
ajst-25616	72	23	technology	technology	NOUN
ajst-25616	72	24	through	through	ADP
ajst-25616	72	25	its	its	PRON
ajst-25616	72	26	ability	ability	NOUN
ajst-25616	72	27	to	to	PART
ajst-25616	72	28	measure	measure	VERB
ajst-25616	72	29	the	the	DET
ajst-25616	72	30	unique	unique	ADJ
ajst-25616	72	31	electrical	electrical	ADJ
ajst-25616	72	32	signatures	signature	NOUN
ajst-25616	72	33	produced	produce	VERB
ajst-25616	72	34	by	by	ADP
ajst-25616	72	35	each	each	DET
ajst-25616	72	36	base	base	NOUN
ajst-25616	72	37	as	as	SCONJ
ajst-25616	72	38	dna	dna	PROPN
ajst-25616	72	39	molecules	molecule	NOUN
ajst-25616	72	40	pass	pass	VERB
ajst-25616	72	41	186	186	NUM
ajst-25616	72	42	through	through	ADP
ajst-25616	72	43	the	the	DET
ajst-25616	72	44	nanopore	nanopore	ADJ
ajst-25616	72	45	.	.	PUNCT
ajst-25616	73	1	the	the	DET
ajst-25616	73	2	distinct	distinct	ADJ
ajst-25616	73	3	current	current	ADJ
ajst-25616	73	4	signatures	signature	NOUN
ajst-25616	73	5	are	be	AUX
ajst-25616	73	6	decoded	decode	VERB
ajst-25616	73	7	to	to	PART
ajst-25616	73	8	identify	identify	VERB
ajst-25616	73	9	the	the	DET
ajst-25616	73	10	specific	specific	ADJ
ajst-25616	73	11	bases	basis	NOUN
ajst-25616	73	12	,	,	PUNCT
ajst-25616	73	13	offering	offer	VERB
ajst-25616	73	14	a	a	DET
ajst-25616	73	15	direct	direct	ADJ
ajst-25616	73	16	and	and	CCONJ
ajst-25616	73	17	label	label	NOUN
ajst-25616	73	18	-	-	PUNCT
ajst-25616	73	19	free	free	ADJ
ajst-25616	73	20	method	method	NOUN
ajst-25616	73	21	for	for	ADP
ajst-25616	73	22	genomic	genomic	ADJ
ajst-25616	73	23	analysis[15	analysis[15	NOUN
ajst-25616	73	24	]	]	PUNCT
ajst-25616	73	25	.	.	PUNCT
ajst-25616	74	1	similarly	similarly	ADV
ajst-25616	74	2	,	,	PUNCT
ajst-25616	74	3	nanopore	nanopore	ADV
ajst-25616	74	4	sequencing	sequence	VERB
ajst-25616	74	5	technology	technology	NOUN
ajst-25616	74	6	is	be	AUX
ajst-25616	74	7	a	a	DET
ajst-25616	74	8	disruptive	disruptive	ADJ
ajst-25616	74	9	and	and	CCONJ
ajst-25616	74	10	innovative	innovative	ADJ
ajst-25616	74	11	third	third	ADJ
ajst-25616	74	12	generation	generation	NOUN
ajst-25616	74	13	sequencing	sequence	VERB
ajst-25616	74	14	technology	technology	NOUN
ajst-25616	74	15	.	.	PUNCT
ajst-25616	75	1	its	its	PRON
ajst-25616	75	2	application	application	NOUN
ajst-25616	75	3	range	range	NOUN
ajst-25616	75	4	includes	include	VERB
ajst-25616	75	5	dna	dna	PROPN
ajst-25616	75	6	and	and	CCONJ
ajst-25616	75	7	rna	rna	NOUN
ajst-25616	75	8	molecules	molecule	NOUN
ajst-25616	75	9	,	,	PUNCT
ajst-25616	75	10	so	so	SCONJ
ajst-25616	75	11	it	it	PRON
ajst-25616	75	12	has	have	AUX
ajst-25616	75	13	been	be	AUX
ajst-25616	75	14	widely	widely	ADV
ajst-25616	75	15	used	use	VERB
ajst-25616	75	16	in	in	ADP
ajst-25616	75	17	environmental	environmental	ADJ
ajst-25616	75	18	science	science	NOUN
ajst-25616	76	1	[	[	X
ajst-25616	76	2	16	16	NUM
ajst-25616	76	3	]	]	X
ajst-25616	76	4	,	,	PUNCT
ajst-25616	76	5	criminal	criminal	ADJ
ajst-25616	76	6	investigation	investigation	NOUN
ajst-25616	76	7	[	[	X
ajst-25616	76	8	17	17	NUM
ajst-25616	76	9	]	]	PUNCT
ajst-25616	76	10	,	,	PUNCT
ajst-25616	76	11	agriculture	agriculture	NOUN
ajst-25616	76	12	[	[	X
ajst-25616	76	13	18	18	NUM
ajst-25616	76	14	]	]	PUNCT
ajst-25616	76	15	,	,	PUNCT
ajst-25616	76	16	basic	basic	ADJ
ajst-25616	76	17	research	research	NOUN
ajst-25616	76	18	[	[	X
ajst-25616	76	19	19	19	NUM
ajst-25616	76	20	]	]	PUNCT
ajst-25616	76	21	,	,	PUNCT
ajst-25616	76	22	medicine	medicine	NOUN
ajst-25616	77	1	[	[	X
ajst-25616	77	2	20,21	20,21	NUM
ajst-25616	77	3	]	]	PUNCT
ajst-25616	77	4	and	and	CCONJ
ajst-25616	77	5	food	food	NOUN
ajst-25616	77	6	[	[	X
ajst-25616	77	7	22	22	NUM
ajst-25616	77	8	]	]	PUNCT
ajst-25616	77	9	.	.	PUNCT
ajst-25616	78	1	however	however	ADV
ajst-25616	78	2	,	,	PUNCT
ajst-25616	78	3	due	due	ADP
ajst-25616	78	4	to	to	ADP
ajst-25616	78	5	its	its	PRON
ajst-25616	78	6	certain	certain	ADJ
ajst-25616	78	7	error	error	NOUN
ajst-25616	78	8	rate	rate	NOUN
ajst-25616	78	9	,	,	PUNCT
ajst-25616	78	10	it	it	PRON
ajst-25616	78	11	will	will	AUX
ajst-25616	78	12	not	not	PART
ajst-25616	78	13	completely	completely	ADV
ajst-25616	78	14	replace	replace	VERB
ajst-25616	78	15	other	other	ADJ
ajst-25616	78	16	sequencing	sequencing	NOUN
ajst-25616	78	17	technologies	technology	NOUN
ajst-25616	78	18	in	in	ADP
ajst-25616	78	19	the	the	DET
ajst-25616	78	20	next	next	ADJ
ajst-25616	78	21	few	few	ADJ
ajst-25616	78	22	years	year	NOUN
ajst-25616	78	23	,	,	PUNCT
ajst-25616	78	24	but	but	CCONJ
ajst-25616	78	25	a	a	DET
ajst-25616	78	26	comprehensive	comprehensive	ADJ
ajst-25616	78	27	and	and	CCONJ
ajst-25616	78	28	systematic	systematic	ADJ
ajst-25616	78	29	understanding	understanding	NOUN
ajst-25616	78	30	and	and	CCONJ
ajst-25616	78	31	improvement	improvement	NOUN
ajst-25616	78	32	of	of	ADP
ajst-25616	78	33	this	this	DET
ajst-25616	78	34	technology	technology	NOUN
ajst-25616	78	35	is	be	AUX
ajst-25616	78	36	still	still	ADV
ajst-25616	78	37	of	of	ADP
ajst-25616	78	38	great	great	ADJ
ajst-25616	78	39	significance	significance	NOUN
ajst-25616	78	40	for	for	ADP
ajst-25616	78	41	future	future	ADJ
ajst-25616	78	42	development	development	NOUN
ajst-25616	78	43	.	.	PUNCT
ajst-25616	79	1	4	4	X
ajst-25616	79	2	.	.	X
ajst-25616	79	3	enrichment	enrichment	NOUN
ajst-25616	79	4	improvement	improvement	NOUN
ajst-25616	79	5	based	base	VERB
ajst-25616	79	6	on	on	ADP
ajst-25616	79	7	crispr	crispr	ADJ
ajst-25616	79	8	/	/	SYM
ajst-25616	79	9	cas	cas	PROPN
ajst-25616	79	10	family	family	NOUN
ajst-25616	79	11	4.1	4.1	NUM
ajst-25616	79	12	.	.	PUNCT
ajst-25616	79	13	basic	basic	ADJ
ajst-25616	79	14	advantage	advantage	NOUN
ajst-25616	79	15	in	in	ADP
ajst-25616	79	16	traditional	traditional	ADJ
ajst-25616	79	17	sequencing	sequence	VERB
ajst-25616	79	18	methods	method	NOUN
ajst-25616	79	19	,	,	PUNCT
ajst-25616	79	20	pcr	pcr	ADJ
ajst-25616	79	21	amplification	amplification	NOUN
ajst-25616	79	22	is	be	AUX
ajst-25616	79	23	usually	usually	ADV
ajst-25616	79	24	required	require	VERB
ajst-25616	79	25	.	.	PUNCT
ajst-25616	80	1	however	however	ADV
ajst-25616	80	2	,	,	PUNCT
ajst-25616	80	3	this	this	DET
ajst-25616	80	4	process	process	NOUN
ajst-25616	80	5	can	can	AUX
ajst-25616	80	6	lead	lead	VERB
ajst-25616	80	7	to	to	ADP
ajst-25616	80	8	a	a	DET
ajst-25616	80	9	very	very	ADV
ajst-25616	80	10	high	high	ADJ
ajst-25616	80	11	error	error	NOUN
ajst-25616	80	12	rate	rate	NOUN
ajst-25616	80	13	,	,	PUNCT
ajst-25616	80	14	especially	especially	ADV
ajst-25616	80	15	when	when	SCONJ
ajst-25616	80	16	amplifying	amplifying	ADJ
ajst-25616	80	17	(	(	PUNCT
ajst-25616	80	18	tandem	tandem	NOUN
ajst-25616	80	19	)	)	PUNCT
ajst-25616	80	20	repeats	repeat	NOUN
ajst-25616	80	21	,	,	PUNCT
ajst-25616	80	22	and	and	CCONJ
ajst-25616	80	23	removes	remove	VERB
ajst-25616	80	24	all	all	DET
ajst-25616	80	25	epigenetic	epigenetic	ADJ
ajst-25616	80	26	marks	mark	NOUN
ajst-25616	80	27	.	.	PUNCT
ajst-25616	81	1	therefore	therefore	ADV
ajst-25616	81	2	,	,	PUNCT
ajst-25616	81	3	the	the	DET
ajst-25616	81	4	use	use	NOUN
ajst-25616	81	5	of	of	ADP
ajst-25616	81	6	amplification	amplification	NOUN
ajst-25616	81	7	methods	method	NOUN
ajst-25616	81	8	hinders	hinder	VERB
ajst-25616	81	9	obtaining	obtain	VERB
ajst-25616	81	10	a	a	DET
ajst-25616	81	11	comprehensive	comprehensive	ADJ
ajst-25616	81	12	genetic	genetic	ADJ
ajst-25616	81	13	and	and	CCONJ
ajst-25616	81	14	epigenetic	epigenetic	ADJ
ajst-25616	81	15	profile	profile	NOUN
ajst-25616	81	16	of	of	ADP
ajst-25616	81	17	the	the	DET
ajst-25616	81	18	tandem	tandem	NOUN
ajst-25616	81	19	repeats	repeat	NOUN
ajst-25616	81	20	[	[	X
ajst-25616	81	21	5	5	NUM
ajst-25616	81	22	]	]	PUNCT
ajst-25616	81	23	.	.	PUNCT
ajst-25616	82	1	at	at	ADP
ajst-25616	82	2	the	the	DET
ajst-25616	82	3	same	same	ADJ
ajst-25616	82	4	time	time	NOUN
ajst-25616	82	5	,	,	PUNCT
ajst-25616	82	6	there	there	PRON
ajst-25616	82	7	are	be	VERB
ajst-25616	82	8	certain	certain	ADJ
ajst-25616	82	9	limitations	limitation	NOUN
ajst-25616	82	10	when	when	SCONJ
ajst-25616	82	11	the	the	DET
ajst-25616	82	12	sample	sample	NOUN
ajst-25616	82	13	dna	dna	PROPN
ajst-25616	82	14	has	have	VERB
ajst-25616	82	15	characteristics	characteristic	NOUN
ajst-25616	82	16	such	such	ADJ
ajst-25616	82	17	as	as	ADP
ajst-25616	82	18	being	be	AUX
ajst-25616	82	19	repetitive	repetitive	ADJ
ajst-25616	82	20	,	,	PUNCT
ajst-25616	82	21	low	low	ADJ
ajst-25616	82	22	complexity	complexity	NOUN
ajst-25616	82	23	,	,	PUNCT
ajst-25616	82	24	or	or	CCONJ
ajst-25616	82	25	rich	rich	ADJ
ajst-25616	82	26	in	in	ADP
ajst-25616	82	27	at	at	ADP
ajst-25616	82	28	/	/	SYM
ajst-25616	82	29	cg	cg	NOUN
ajst-25616	82	30	.	.	PUNCT
ajst-25616	83	1	as	as	ADP
ajst-25616	83	2	a	a	DET
ajst-25616	83	3	result	result	NOUN
ajst-25616	83	4	,	,	PUNCT
ajst-25616	83	5	in	in	ADP
ajst-25616	83	6	recent	recent	ADJ
ajst-25616	83	7	years	year	NOUN
ajst-25616	83	8	,	,	PUNCT
ajst-25616	83	9	a	a	DET
ajst-25616	83	10	large	large	ADJ
ajst-25616	83	11	number	number	NOUN
ajst-25616	83	12	of	of	ADP
ajst-25616	83	13	researchers	researcher	NOUN
ajst-25616	83	14	have	have	AUX
ajst-25616	83	15	developed	develop	VERB
ajst-25616	83	16	targeted	target	VERB
ajst-25616	83	17	sequencing	sequence	VERB
ajst-25616	83	18	technologies	technology	NOUN
ajst-25616	83	19	,	,	PUNCT
ajst-25616	83	20	including	include	VERB
ajst-25616	83	21	but	but	CCONJ
ajst-25616	83	22	not	not	PART
ajst-25616	83	23	limited	limit	VERB
ajst-25616	83	24	to	to	ADP
ajst-25616	83	25	the	the	DET
ajst-25616	83	26	xdrop	xdrop	NOUN
ajst-25616	83	27	system	system	NOUN
ajst-25616	84	1	[	[	X
ajst-25616	84	2	23	23	NUM
ajst-25616	84	3	]	]	PUNCT
ajst-25616	84	4	,	,	PUNCT
ajst-25616	84	5	adaptive	adaptive	ADJ
ajst-25616	84	6	sampling	sample	VERB
ajst-25616	84	7	[	[	X
ajst-25616	84	8	24	24	NUM
ajst-25616	84	9	]	]	PUNCT
ajst-25616	84	10	,	,	PUNCT
ajst-25616	84	11	and	and	CCONJ
ajst-25616	84	12	crispr	crispr	ADJ
ajst-25616	84	13	/	/	SYM
ajst-25616	84	14	cas	cas	PROPN
ajst-25616	84	15	family	family	NOUN
ajst-25616	84	16	-	-	PUNCT
ajst-25616	84	17	based	base	VERB
ajst-25616	84	18	third	third	ADJ
ajst-25616	84	19	-	-	PUNCT
ajst-25616	84	20	generation	generation	NOUN
ajst-25616	84	21	sequencing	sequence	VERB
ajst-25616	84	22	technologies	technology	NOUN
ajst-25616	84	23	,	,	PUNCT
ajst-25616	84	24	which	which	PRON
ajst-25616	84	25	can	can	AUX
ajst-25616	84	26	perform	perform	VERB
ajst-25616	84	27	targeted	target	VERB
ajst-25616	84	28	sequencing	sequence	VERB
ajst-25616	84	29	on	on	ADP
ajst-25616	84	30	specific	specific	ADJ
ajst-25616	84	31	dna	dna	NOUN
ajst-25616	84	32	sites	site	NOUN
ajst-25616	84	33	and	and	CCONJ
ajst-25616	84	34	have	have	VERB
ajst-25616	84	35	a	a	DET
ajst-25616	84	36	stronger	strong	ADJ
ajst-25616	84	37	ability	ability	NOUN
ajst-25616	84	38	to	to	PART
ajst-25616	84	39	resolve	resolve	VERB
ajst-25616	84	40	svs	sv	VERB
ajst-25616	84	41	and	and	CCONJ
ajst-25616	84	42	other	other	ADJ
ajst-25616	84	43	complex	complex	ADJ
ajst-25616	84	44	regions	region	NOUN
ajst-25616	84	45	in	in	ADP
ajst-25616	84	46	the	the	DET
ajst-25616	84	47	human	human	ADJ
ajst-25616	84	48	genome	genome	NOUN
ajst-25616	84	49	[	[	X
ajst-25616	84	50	25	25	NUM
ajst-25616	84	51	]	]	PUNCT
ajst-25616	84	52	.	.	PUNCT
ajst-25616	85	1	in	in	ADP
ajst-25616	85	2	crispr	crispr	NOUN
ajst-25616	85	3	-	-	PUNCT
ajst-25616	85	4	mediated	mediate	VERB
ajst-25616	85	5	third	third	ADJ
ajst-25616	85	6	-	-	PUNCT
ajst-25616	85	7	generation	generation	NOUN
ajst-25616	85	8	sequencing	sequence	VERB
ajst-25616	85	9	technology	technology	NOUN
ajst-25616	85	10	,	,	PUNCT
ajst-25616	85	11	it	it	PRON
ajst-25616	85	12	not	not	PART
ajst-25616	85	13	only	only	ADV
ajst-25616	85	14	enables	enable	VERB
ajst-25616	85	15	researchers	researcher	NOUN
ajst-25616	85	16	to	to	PART
ajst-25616	85	17	fully	fully	ADV
ajst-25616	85	18	characterize	characterize	VERB
ajst-25616	85	19	the	the	DET
ajst-25616	85	20	amplification	amplification	NOUN
ajst-25616	85	21	of	of	ADP
ajst-25616	85	22	homozygotes	homozygote	NOUN
ajst-25616	85	23	for	for	ADP
ajst-25616	85	24	the	the	DET
ajst-25616	85	25	first	first	ADJ
ajst-25616	85	26	time	time	NOUN
ajst-25616	85	27	,	,	PUNCT
ajst-25616	85	28	providing	provide	VERB
ajst-25616	85	29	a	a	DET
ajst-25616	85	30	deeper	deep	ADJ
ajst-25616	85	31	insight	insight	NOUN
ajst-25616	85	32	into	into	ADP
ajst-25616	85	33	the	the	DET
ajst-25616	85	34	instability	instability	NOUN
ajst-25616	85	35	of	of	ADP
ajst-25616	85	36	repeat	repeat	NOUN
ajst-25616	85	37	length	length	NOUN
ajst-25616	85	38	and	and	CCONJ
ajst-25616	85	39	chimera	chimera	NOUN
ajst-25616	85	40	that	that	SCONJ
ajst-25616	85	41	traditional	traditional	ADJ
ajst-25616	85	42	methods	method	NOUN
ajst-25616	85	43	can	can	AUX
ajst-25616	85	44	not	not	PART
ajst-25616	85	45	accurately	accurately	ADV
ajst-25616	85	46	estimate	estimate	VERB
ajst-25616	85	47	[	[	X
ajst-25616	85	48	26	26	NUM
ajst-25616	85	49	]	]	X
ajst-25616	85	50	;	;	PUNCT
ajst-25616	85	51	it	it	PRON
ajst-25616	85	52	can	can	AUX
ajst-25616	85	53	also	also	ADV
ajst-25616	85	54	determine	determine	VERB
ajst-25616	85	55	the	the	DET
ajst-25616	85	56	results	result	NOUN
ajst-25616	85	57	of	of	ADP
ajst-25616	85	58	genome	genome	NOUN
ajst-25616	85	59	editing	editing	NOUN
ajst-25616	85	60	at	at	ADP
ajst-25616	85	61	any	any	DET
ajst-25616	85	62	site	site	NOUN
ajst-25616	85	63	(	(	PUNCT
ajst-25616	85	64	including	include	VERB
ajst-25616	85	65	"	"	PUNCT
ajst-25616	85	66	dark	dark	ADJ
ajst-25616	85	67	"	"	PUNCT
ajst-25616	85	68	regions	region	NOUN
ajst-25616	85	69	)	)	PUNCT
ajst-25616	85	70	,	,	PUNCT
ajst-25616	85	71	including	include	VERB
ajst-25616	85	72	the	the	DET
ajst-25616	85	73	frequency	frequency	NOUN
ajst-25616	85	74	of	of	ADP
ajst-25616	85	75	non	non	ADJ
ajst-25616	85	76	-	-	ADJ
ajst-25616	85	77	homologous	homologous	ADJ
ajst-25616	85	78	end	end	NOUN
ajst-25616	85	79	joining	join	VERB
ajst-25616	85	80	(	(	PUNCT
ajst-25616	85	81	nhej	nhej	ADJ
ajst-25616	85	82	)	)	PUNCT
ajst-25616	85	83	and	and	CCONJ
ajst-25616	85	84	homology	homology	NOUN
ajst-25616	85	85	-	-	PUNCT
ajst-25616	85	86	directed	direct	VERB
ajst-25616	85	87	repair	repair	NOUN
ajst-25616	85	88	(	(	PUNCT
ajst-25616	85	89	hdr	hdr	NOUN
ajst-25616	85	90	)	)	PUNCT
ajst-25616	86	1	[	[	X
ajst-25616	86	2	27	27	NUM
ajst-25616	86	3	]	]	PUNCT
ajst-25616	86	4	.	.	PUNCT
ajst-25616	87	1	at	at	ADP
ajst-25616	87	2	the	the	DET
ajst-25616	87	3	same	same	ADJ
ajst-25616	87	4	time	time	NOUN
ajst-25616	87	5	,	,	PUNCT
ajst-25616	87	6	compared	compare	VERB
ajst-25616	87	7	with	with	ADP
ajst-25616	87	8	str	str	NOUN
ajst-25616	87	9	analysis	analysis	NOUN
ajst-25616	87	10	,	,	PUNCT
ajst-25616	87	11	the	the	DET
ajst-25616	87	12	sequence	sequence	NOUN
ajst-25616	87	13	-	-	PUNCT
ajst-25616	87	14	level	level	NOUN
ajst-25616	87	15	data	datum	NOUN
ajst-25616	87	16	generated	generate	VERB
ajst-25616	87	17	by	by	ADP
ajst-25616	87	18	crispr	crispr	NOUN
ajst-25616	87	19	-	-	PUNCT
ajst-25616	87	20	guided	guide	VERB
ajst-25616	87	21	smrt	smrt	NOUN
ajst-25616	87	22	sequencing	sequencing	NOUN
ajst-25616	87	23	technology	technology	NOUN
ajst-25616	87	24	provides	provide	VERB
ajst-25616	87	25	higher	high	ADJ
ajst-25616	87	26	genotyping	genotyping	NOUN
ajst-25616	87	27	accuracy	accuracy	NOUN
ajst-25616	87	28	,	,	PUNCT
ajst-25616	87	29	thanks	thank	NOUN
ajst-25616	87	30	to	to	ADP
ajst-25616	87	31	its	its	PRON
ajst-25616	87	32	ability	ability	NOUN
ajst-25616	87	33	to	to	PART
ajst-25616	87	34	detect	detect	VERB
ajst-25616	87	35	all	all	DET
ajst-25616	87	36	instabilities	instability	NOUN
ajst-25616	87	37	amplified	amplify	VERB
ajst-25616	87	38	in	in	ADP
ajst-25616	87	39	a	a	DET
ajst-25616	87	40	particular	particular	ADJ
ajst-25616	87	41	allele	allele	NOUN
ajst-25616	87	42	[	[	X
ajst-25616	87	43	27	27	NUM
ajst-25616	87	44	]	]	PUNCT
ajst-25616	87	45	,	,	PUNCT
ajst-25616	87	46	thereby	thereby	ADV
ajst-25616	87	47	more	more	ADV
ajst-25616	87	48	accurately	accurately	ADV
ajst-25616	87	49	characterizing	characterize	VERB
ajst-25616	87	50	the	the	DET
ajst-25616	87	51	dynamic	dynamic	ADJ
ajst-25616	87	52	nature	nature	NOUN
ajst-25616	87	53	of	of	ADP
ajst-25616	87	54	the	the	DET
ajst-25616	87	55	genome	genome	NOUN
ajst-25616	87	56	.	.	PUNCT
ajst-25616	88	1	this	this	PRON
ajst-25616	88	2	is	be	AUX
ajst-25616	88	3	of	of	ADP
ajst-25616	88	4	great	great	ADJ
ajst-25616	88	5	significance	significance	NOUN
ajst-25616	88	6	for	for	ADP
ajst-25616	88	7	assessing	assess	VERB
ajst-25616	88	8	the	the	DET
ajst-25616	88	9	effectiveness	effectiveness	NOUN
ajst-25616	88	10	and	and	CCONJ
ajst-25616	88	11	safety	safety	NOUN
ajst-25616	88	12	of	of	ADP
ajst-25616	88	13	gene	gene	NOUN
ajst-25616	88	14	-	-	PUNCT
ajst-25616	88	15	editing	edit	VERB
ajst-25616	88	16	technologies	technology	NOUN
ajst-25616	88	17	.	.	PUNCT
ajst-25616	89	1	the	the	DET
ajst-25616	89	2	following	follow	VERB
ajst-25616	89	3	will	will	AUX
ajst-25616	89	4	introduce	introduce	VERB
ajst-25616	89	5	the	the	DET
ajst-25616	89	6	general	general	ADJ
ajst-25616	89	7	methods	method	NOUN
ajst-25616	89	8	and	and	CCONJ
ajst-25616	89	9	progress	progress	NOUN
ajst-25616	89	10	of	of	ADP
ajst-25616	89	11	two	two	NUM
ajst-25616	89	12	types	type	NOUN
ajst-25616	89	13	of	of	ADP
ajst-25616	89	14	sequencing	sequence	VERB
ajst-25616	89	15	mediated	mediate	VERB
ajst-25616	89	16	by	by	ADP
ajst-25616	89	17	the	the	DET
ajst-25616	89	18	crispr	crispr	PROPN
ajst-25616	89	19	/	/	SYM
ajst-25616	89	20	cas	cas	PROPN
ajst-25616	89	21	family	family	NOUN
ajst-25616	89	22	.	.	PUNCT
ajst-25616	90	1	4.2	4.2	NUM
ajst-25616	90	2	.	.	PUNCT
ajst-25616	90	3	crispr	crispr	NOUN
ajst-25616	90	4	-	-	PUNCT
ajst-25616	90	5	mediated	mediate	VERB
ajst-25616	90	6	smrt	smrt	NOUN
ajst-25616	90	7	sequencing	sequence	VERB
ajst-25616	90	8	4.2.1	4.2.1	NUM
ajst-25616	90	9	.	.	PUNCT
ajst-25616	91	1	construction	construction	NOUN
ajst-25616	91	2	of	of	ADP
ajst-25616	91	3	crispr	crispr	ADJ
ajst-25616	91	4	/	/	SYM
ajst-25616	91	5	cas9	cas9	NOUN
ajst-25616	91	6	system	system	NOUN
ajst-25616	91	7	the	the	DET
ajst-25616	91	8	process	process	NOUN
ajst-25616	91	9	primarily	primarily	ADV
ajst-25616	91	10	involves	involve	VERB
ajst-25616	91	11	the	the	DET
ajst-25616	91	12	design	design	NOUN
ajst-25616	91	13	and	and	CCONJ
ajst-25616	91	14	synthesis	synthesis	NOUN
ajst-25616	91	15	of	of	ADP
ajst-25616	91	16	guide	guide	NOUN
ajst-25616	91	17	rna	rna	NOUN
ajst-25616	91	18	(	(	PUNCT
ajst-25616	91	19	grna	grna	NOUN
ajst-25616	91	20	)	)	PUNCT
ajst-25616	91	21	and	and	CCONJ
ajst-25616	91	22	its	its	PRON
ajst-25616	91	23	assembly	assembly	NOUN
ajst-25616	91	24	with	with	ADP
ajst-25616	91	25	the	the	DET
ajst-25616	91	26	cas	cas	PROPN
ajst-25616	91	27	nuclease	nuclease	NOUN
ajst-25616	91	28	.	.	PUNCT
ajst-25616	92	1	prior	prior	ADV
ajst-25616	92	2	to	to	ADP
ajst-25616	92	3	the	the	DET
ajst-25616	92	4	research	research	NOUN
ajst-25616	92	5	,	,	PUNCT
ajst-25616	92	6	it	it	PRON
ajst-25616	92	7	is	be	AUX
ajst-25616	92	8	essential	essential	ADJ
ajst-25616	92	9	to	to	PART
ajst-25616	92	10	identify	identify	VERB
ajst-25616	92	11	the	the	DET
ajst-25616	92	12	target	target	NOUN
ajst-25616	92	13	gene	gene	NOUN
ajst-25616	92	14	site	site	NOUN
ajst-25616	92	15	and	and	CCONJ
ajst-25616	92	16	craft	craft	VERB
ajst-25616	92	17	the	the	DET
ajst-25616	92	18	grna	grna	NOUN
ajst-25616	92	19	based	base	VERB
ajst-25616	92	20	on	on	ADP
ajst-25616	92	21	the	the	DET
ajst-25616	92	22	sequence	sequence	NOUN
ajst-25616	92	23	of	of	ADP
ajst-25616	92	24	the	the	DET
ajst-25616	92	25	target	target	NOUN
ajst-25616	92	26	gene	gene	NOUN
ajst-25616	92	27	.	.	PUNCT
ajst-25616	93	1	the	the	DET
ajst-25616	93	2	grnas	grna	NOUN
ajst-25616	93	3	are	be	AUX
ajst-25616	93	4	created	create	VERB
ajst-25616	93	5	by	by	ADP
ajst-25616	93	6	annealing	anneal	VERB
ajst-25616	93	7	the	the	DET
ajst-25616	93	8	crispr	crispr	PROPN
ajst-25616	93	9	rna	rna	NOUN
ajst-25616	93	10	(	(	PUNCT
ajst-25616	93	11	crrna	crrna	PROPN
ajst-25616	93	12	)	)	PUNCT
ajst-25616	93	13	with	with	ADP
ajst-25616	93	14	the	the	DET
ajst-25616	93	15	trans	trans	ADJ
ajst-25616	93	16	-	-	ADJ
ajst-25616	93	17	activating	activating	ADJ
ajst-25616	93	18	crrna	crrna	NOUN
ajst-25616	93	19	(	(	PUNCT
ajst-25616	93	20	tracrrna	tracrrna	NOUN
ajst-25616	93	21	)	)	PUNCT
ajst-25616	93	22	,	,	PUNCT
ajst-25616	93	23	and	and	CCONJ
ajst-25616	93	24	it	it	PRON
ajst-25616	93	25	is	be	AUX
ajst-25616	93	26	crucial	crucial	ADJ
ajst-25616	93	27	to	to	PART
ajst-25616	93	28	ensure	ensure	VERB
ajst-25616	93	29	complementarity	complementarity	NOUN
ajst-25616	93	30	with	with	ADP
ajst-25616	93	31	the	the	DET
ajst-25616	93	32	target	target	NOUN
ajst-25616	93	33	sequence	sequence	NOUN
ajst-25616	93	34	[	[	X
ajst-25616	93	35	28	28	NUM
ajst-25616	93	36	]	]	PUNCT
ajst-25616	93	37	.	.	PUNCT
ajst-25616	94	1	we	we	PRON
ajst-25616	94	2	recommend	recommend	VERB
ajst-25616	94	3	utilizing	utilize	VERB
ajst-25616	94	4	an	an	DET
ajst-25616	94	5	online	online	ADJ
ajst-25616	94	6	crispr	crispr	ADJ
ajst-25616	94	7	rna	rna	NOUN
ajst-25616	94	8	configurator	configurator	NOUN
ajst-25616	94	9	accessible	accessible	ADJ
ajst-25616	94	10	on	on	ADP
ajst-25616	94	11	the	the	DET
ajst-25616	94	12	dharmacon	dharmacon	ADJ
ajst-25616	94	13	website	website	NOUN
ajst-25616	94	14	to	to	PART
ajst-25616	94	15	generate	generate	VERB
ajst-25616	94	16	the	the	DET
ajst-25616	94	17	anticipated	anticipate	VERB
ajst-25616	94	18	target	target	NOUN
ajst-25616	94	19	sequence	sequence	NOUN
ajst-25616	94	20	and	and	CCONJ
ajst-25616	94	21	verify	verify	VERB
ajst-25616	94	22	the	the	DET
ajst-25616	94	23	specificity	specificity	NOUN
ajst-25616	94	24	of	of	ADP
ajst-25616	94	25	the	the	DET
ajst-25616	94	26	target	target	NOUN
ajst-25616	94	27	against	against	ADP
ajst-25616	94	28	the	the	DET
ajst-25616	94	29	human	human	ADJ
ajst-25616	94	30	genome	genome	NOUN
ajst-25616	94	31	reference	reference	NOUN
ajst-25616	94	32	sequence	sequence	NOUN
ajst-25616	94	33	to	to	PART
ajst-25616	94	34	guarantee	guarantee	VERB
ajst-25616	94	35	recognition	recognition	NOUN
ajst-25616	94	36	by	by	ADP
ajst-25616	94	37	cas9	cas9	NOUN
ajst-25616	94	38	without	without	ADP
ajst-25616	94	39	binding	bind	VERB
ajst-25616	94	40	to	to	ADP
ajst-25616	94	41	other	other	ADJ
ajst-25616	94	42	proteins	protein	NOUN
ajst-25616	94	43	[	[	X
ajst-25616	94	44	28	28	NUM
ajst-25616	94	45	]	]	PUNCT
ajst-25616	94	46	.	.	PUNCT
ajst-25616	95	1	ultimately	ultimately	ADV
ajst-25616	95	2	,	,	PUNCT
ajst-25616	95	3	the	the	DET
ajst-25616	95	4	crispr	crispr	ADJ
ajst-25616	95	5	/	/	SYM
ajst-25616	95	6	cas9	cas9	NOUN
ajst-25616	95	7	complex	complex	NOUN
ajst-25616	95	8	is	be	AUX
ajst-25616	95	9	synthesized	synthesize	VERB
ajst-25616	95	10	using	use	VERB
ajst-25616	95	11	chemical	chemical	ADJ
ajst-25616	95	12	methods	method	NOUN
ajst-25616	95	13	,	,	PUNCT
ajst-25616	95	14	and	and	CCONJ
ajst-25616	95	15	further	further	ADJ
ajst-25616	95	16	elaboration	elaboration	NOUN
ajst-25616	95	17	on	on	ADP
ajst-25616	95	18	this	this	DET
ajst-25616	95	19	point	point	NOUN
ajst-25616	95	20	is	be	AUX
ajst-25616	95	21	unnecessary	unnecessary	ADJ
ajst-25616	95	22	.	.	PUNCT
ajst-25616	96	1	4.2.2	4.2.2	X
ajst-25616	96	2	.	.	PUNCT
ajst-25616	97	1	preparation	preparation	NOUN
ajst-25616	97	2	of	of	ADP
ajst-25616	97	3	smrtbell	smrtbell	NOUN
ajst-25616	97	4	template	template	NOUN
ajst-25616	97	5	for	for	ADP
ajst-25616	97	6	the	the	DET
ajst-25616	97	7	target	target	NOUN
ajst-25616	97	8	gene	gene	NOUN
ajst-25616	97	9	locus	locus	NOUN
ajst-25616	97	10	,	,	PUNCT
ajst-25616	97	11	an	an	DET
ajst-25616	97	12	amplification	amplification	NOUN
ajst-25616	97	13	-	-	PUNCT
ajst-25616	97	14	free	free	ADJ
ajst-25616	97	15	targeted	target	VERB
ajst-25616	97	16	enrichment	enrichment	NOUN
ajst-25616	97	17	method	method	NOUN
ajst-25616	97	18	using	use	VERB
ajst-25616	97	19	cas9	cas9	NOUN
ajst-25616	97	20	is	be	AUX
ajst-25616	97	21	utilized	utilize	VERB
ajst-25616	97	22	.	.	PUNCT
ajst-25616	98	1	initially	initially	ADV
ajst-25616	98	2	,	,	PUNCT
ajst-25616	98	3	dna	dna	PROPN
ajst-25616	98	4	is	be	AUX
ajst-25616	98	5	fragmented	fragment	VERB
ajst-25616	98	6	to	to	PART
ajst-25616	98	7	simplify	simplify	VERB
ajst-25616	98	8	the	the	DET
ajst-25616	98	9	genome	genome	NOUN
ajst-25616	98	10	.	.	PUNCT
ajst-25616	99	1	the	the	DET
ajst-25616	99	2	dna	dna	PROPN
ajst-25616	99	3	fragments	fragment	NOUN
ajst-25616	99	4	are	be	AUX
ajst-25616	99	5	then	then	ADV
ajst-25616	99	6	connected	connect	VERB
ajst-25616	99	7	to	to	ADP
ajst-25616	99	8	site	site	NOUN
ajst-25616	99	9	-	-	PUNCT
ajst-25616	99	10	specific	specific	ADJ
ajst-25616	99	11	hairpin	hairpin	NOUN
ajst-25616	99	12	adapters	adapter	NOUN
ajst-25616	99	13	that	that	PRON
ajst-25616	99	14	bear	bear	VERB
ajst-25616	99	15	the	the	DET
ajst-25616	99	16	used	use	VERB
ajst-25616	99	17	cutting	cutting	NOUN
ajst-25616	99	18	sites	site	NOUN
ajst-25616	99	19	,	,	PUNCT
ajst-25616	99	20	and	and	CCONJ
ajst-25616	99	21	these	these	PRON
ajst-25616	99	22	are	be	AUX
ajst-25616	99	23	ligated	ligate	VERB
ajst-25616	99	24	into	into	ADP
ajst-25616	99	25	smrtbell	smrtbell	NOUN
ajst-25616	99	26	template	template	NOUN
ajst-25616	99	27	libraries	library	NOUN
ajst-25616	99	28	by	by	ADP
ajst-25616	99	29	a	a	DET
ajst-25616	99	30	ligase	ligase	NOUN
ajst-25616	99	31	.	.	PUNCT
ajst-25616	100	1	other	other	ADJ
ajst-25616	100	2	dna	dna	PROPN
ajst-25616	100	3	fragments	fragment	NOUN
ajst-25616	100	4	,	,	PUNCT
ajst-25616	100	5	incompatible	incompatible	ADJ
ajst-25616	100	6	with	with	ADP
ajst-25616	100	7	the	the	DET
ajst-25616	100	8	smrtbell	smrtbell	NOUN
ajst-25616	100	9	adapters	adapter	NOUN
ajst-25616	100	10	,	,	PUNCT
ajst-25616	100	11	are	be	AUX
ajst-25616	100	12	digested	digest	VERB
ajst-25616	100	13	by	by	ADP
ajst-25616	100	14	nucleases	nuclease	NOUN
ajst-25616	100	15	.	.	PUNCT
ajst-25616	101	1	subsequently	subsequently	ADV
ajst-25616	101	2	,	,	PUNCT
ajst-25616	101	3	the	the	DET
ajst-25616	101	4	nucleases	nuclease	NOUN
ajst-25616	101	5	are	be	AUX
ajst-25616	101	6	combined	combine	VERB
ajst-25616	101	7	with	with	ADP
ajst-25616	101	8	the	the	DET
ajst-25616	101	9	smrtbell	smrtbell	NOUN
ajst-25616	101	10	templates	template	NOUN
ajst-25616	101	11	that	that	PRON
ajst-25616	101	12	have	have	AUX
ajst-25616	101	13	been	be	AUX
ajst-25616	101	14	prepared	prepare	VERB
ajst-25616	101	15	with	with	ADP
ajst-25616	101	16	the	the	DET
ajst-25616	101	17	specific	specific	ADJ
ajst-25616	101	18	grna	grna	NOUN
ajst-25616	101	19	digestion	digestion	NOUN
ajst-25616	101	20	.	.	PUNCT
ajst-25616	102	1	after	after	ADP
ajst-25616	102	2	the	the	DET
ajst-25616	102	3	reaction	reaction	NOUN
ajst-25616	102	4	,	,	PUNCT
ajst-25616	102	5	polya	polya	NOUN
ajst-25616	102	6	hairpin	hairpin	VERB
ajst-25616	102	7	capture	capture	NOUN
ajst-25616	102	8	adapters	adapter	NOUN
ajst-25616	102	9	are	be	AUX
ajst-25616	102	10	ligated	ligate	VERB
ajst-25616	102	11	to	to	ADP
ajst-25616	102	12	the	the	DET
ajst-25616	102	13	digested	digest	VERB
ajst-25616	102	14	,	,	PUNCT
ajst-25616	102	15	targeted	targeted	ADJ
ajst-25616	102	16	dna	dna	NOUN
ajst-25616	102	17	;	;	PUNCT
ajst-25616	102	18	this	this	DET
ajst-25616	102	19	structure	structure	NOUN
ajst-25616	102	20	allows	allow	VERB
ajst-25616	102	21	for	for	ADP
ajst-25616	102	22	effective	effective	ADJ
ajst-25616	102	23	rna	rna	NOUN
ajst-25616	102	24	binding	bind	VERB
ajst-25616	102	25	and	and	CCONJ
ajst-25616	102	26	selective	selective	ADJ
ajst-25616	102	27	capture	capture	NOUN
ajst-25616	102	28	and	and	CCONJ
ajst-25616	102	29	binding	bind	VERB
ajst-25616	102	30	[	[	X
ajst-25616	102	31	28	28	NUM
ajst-25616	102	32	]	]	PUNCT
ajst-25616	102	33	,	,	PUNCT
ajst-25616	102	34	resulting	result	VERB
ajst-25616	102	35	in	in	ADP
ajst-25616	102	36	the	the	DET
ajst-25616	102	37	final	final	ADJ
ajst-25616	102	38	asymmetric	asymmetric	ADJ
ajst-25616	102	39	smrtbell	smrtbell	NOUN
ajst-25616	102	40	template	template	NOUN
ajst-25616	102	41	molecule	molecule	NOUN
ajst-25616	102	42	library	library	NOUN
ajst-25616	102	43	,	,	PUNCT
ajst-25616	102	44	which	which	PRON
ajst-25616	102	45	is	be	AUX
ajst-25616	102	46	enriched	enrich	VERB
ajst-25616	102	47	using	use	VERB
ajst-25616	102	48	pacific	pacific	PROPN
ajst-25616	102	49	biosciences	bioscience	NOUN
ajst-25616	102	50	'	'	PART
ajst-25616	102	51	magbead	magbead	ADJ
ajst-25616	102	52	system	system	NOUN
ajst-25616	102	53	.	.	PUNCT
ajst-25616	103	1	4.2.3	4.2.3	X
ajst-25616	103	2	.	.	PUNCT
ajst-25616	103	3	targeted	target	VERB
ajst-25616	103	4	smrt	smrt	NOUN
ajst-25616	103	5	sequencing	sequence	VERB
ajst-25616	103	6	to	to	PART
ajst-25616	103	7	prepare	prepare	VERB
ajst-25616	103	8	for	for	ADP
ajst-25616	103	9	sequencing	sequence	VERB
ajst-25616	103	10	,	,	PUNCT
ajst-25616	103	11	it	it	PRON
ajst-25616	103	12	is	be	AUX
ajst-25616	103	13	essential	essential	ADJ
ajst-25616	103	14	to	to	PART
ajst-25616	103	15	first	first	ADV
ajst-25616	103	16	remove	remove	VERB
ajst-25616	103	17	excess	excess	ADJ
ajst-25616	103	18	dna	dna	NOUN
ajst-25616	103	19	and	and	CCONJ
ajst-25616	103	20	various	various	ADJ
ajst-25616	103	21	enzymes	enzyme	NOUN
ajst-25616	103	22	.	.	PUNCT
ajst-25616	104	1	to	to	PART
ajst-25616	104	2	ready	ready	VERB
ajst-25616	104	3	the	the	DET
ajst-25616	104	4	target	target	NOUN
ajst-25616	104	5	fragments	fragment	NOUN
ajst-25616	104	6	for	for	ADP
ajst-25616	104	7	smrt	smrt	NOUN
ajst-25616	104	8	sequencing	sequencing	NOUN
ajst-25616	104	9	,	,	PUNCT
ajst-25616	104	10	a	a	DET
ajst-25616	104	11	standard	standard	ADJ
ajst-25616	104	12	pacbio	pacbio	NOUN
ajst-25616	104	13	primer	primer	NOUN
ajst-25616	104	14	that	that	PRON
ajst-25616	104	15	does	do	AUX
ajst-25616	104	16	not	not	PART
ajst-25616	104	17	contain	contain	VERB
ajst-25616	104	18	a	a	DET
ajst-25616	104	19	polya	polya	NOUN
ajst-25616	104	20	sequence	sequence	NOUN
ajst-25616	104	21	is	be	AUX
ajst-25616	104	22	annealed	anneal	VERB
ajst-25616	104	23	,	,	PUNCT
ajst-25616	104	24	followed	follow	VERB
ajst-25616	104	25	by	by	ADP
ajst-25616	104	26	an	an	DET
ajst-25616	104	27	incubation	incubation	NOUN
ajst-25616	104	28	process	process	NOUN
ajst-25616	104	29	.	.	PUNCT
ajst-25616	105	1	if	if	SCONJ
ajst-25616	105	2	possible	possible	ADJ
ajst-25616	105	3	,	,	PUNCT
ajst-25616	105	4	utilize	utilize	VERB
ajst-25616	105	5	circular	circular	ADJ
ajst-25616	105	6	consensus	consensus	NOUN
ajst-25616	105	7	sequencing	sequence	VERB
ajst-25616	105	8	(	(	PUNCT
ajst-25616	105	9	ccs	ccs	PROPN
ajst-25616	105	10	)	)	PUNCT
ajst-25616	105	11	reads	read	VERB
ajst-25616	105	12	to	to	PART
ajst-25616	105	13	enhance	enhance	VERB
ajst-25616	105	14	the	the	DET
ajst-25616	105	15	accuracy	accuracy	NOUN
ajst-25616	105	16	of	of	ADP
ajst-25616	105	17	sequencing	sequence	VERB
ajst-25616	105	18	.	.	PUNCT
ajst-25616	106	1	ultimately	ultimately	ADV
ajst-25616	106	2	,	,	PUNCT
ajst-25616	106	3	this	this	DET
ajst-25616	106	4	process	process	NOUN
ajst-25616	106	5	generates	generate	VERB
ajst-25616	106	6	a	a	DET
ajst-25616	106	7	genome	genome	NOUN
ajst-25616	106	8	coverage	coverage	NOUN
ajst-25616	106	9	map	map	NOUN
ajst-25616	106	10	and	and	CCONJ
ajst-25616	106	11	facilitates	facilitate	VERB
ajst-25616	106	12	mapping	mapping	NOUN
ajst-25616	106	13	.	.	PUNCT
ajst-25616	107	1	4.3	4.3	NUM
ajst-25616	107	2	.	.	PUNCT
ajst-25616	107	3	crispr	crispr	NOUN
ajst-25616	107	4	-	-	PUNCT
ajst-25616	107	5	mediated	mediate	VERB
ajst-25616	107	6	nanopore	nanopore	ADV
ajst-25616	107	7	sequencing	sequence	VERB
ajst-25616	107	8	4.3.1	4.3.1	NUM
ajst-25616	107	9	.	.	PUNCT
ajst-25616	108	1	cas9	cas9	NOUN
ajst-25616	108	2	-	-	PUNCT
ajst-25616	108	3	mediated	mediate	VERB
ajst-25616	108	4	nanopore	nanopore	ADV
ajst-25616	108	5	sequencing	sequence	VERB
ajst-25616	108	6	4.3.1.1	4.3.1.1	NUM
ajst-25616	108	7	simple	simple	ADJ
ajst-25616	108	8	mediated	mediate	VERB
ajst-25616	108	9	method	method	NOUN
ajst-25616	108	10	first	first	ADV
ajst-25616	108	11	,	,	PUNCT
ajst-25616	108	12	the	the	DET
ajst-25616	108	13	subsequent	subsequent	ADJ
ajst-25616	108	14	guide	guide	NOUN
ajst-25616	108	15	crispr	crispr	ADJ
ajst-25616	108	16	-	-	PUNCT
ajst-25616	108	17	rnas	rna	NOUN
ajst-25616	108	18	need	need	VERB
ajst-25616	108	19	to	to	PART
ajst-25616	108	20	be	be	AUX
ajst-25616	108	21	designed	design	VERB
ajst-25616	108	22	,	,	PUNCT
ajst-25616	108	23	assembled	assemble	VERB
ajst-25616	108	24	from	from	ADP
ajst-25616	108	25	synthetic	synthetic	ADJ
ajst-25616	108	26	crrna	crrna	NOUN
ajst-25616	108	27	(	(	PUNCT
ajst-25616	108	28	idt	idt	ADJ
ajst-25616	108	29	,	,	PUNCT
ajst-25616	108	30	custom	custom	NOUN
ajst-25616	108	31	designed	design	VERB
ajst-25616	108	32	)	)	PUNCT
ajst-25616	108	33	and	and	CCONJ
ajst-25616	108	34	tracrrna	tracrrna	NOUN
ajst-25616	108	35	(	(	PUNCT
ajst-25616	108	36	idt	idt	ADJ
ajst-25616	108	37	,	,	PUNCT
ajst-25616	108	38	1072532	1072532	NUM
ajst-25616	108	39	)	)	PUNCT
ajst-25616	108	40	into	into	ADP
ajst-25616	108	41	a	a	DET
ajst-25616	108	42	duplex	duplex	NOUN
ajst-25616	108	43	.	.	PUNCT
ajst-25616	109	1	the	the	DET
ajst-25616	109	2	crrna	crrna	NOUN
ajst-25616	109	3	can	can	AUX
ajst-25616	109	4	be	be	AUX
ajst-25616	109	5	designed	design	VERB
ajst-25616	109	6	using	use	VERB
ajst-25616	109	7	crispick	crispick	PROPN
ajst-25616	109	8	,	,	PUNCT
ajst-25616	109	9	the	the	DET
ajst-25616	109	10	idt	idt	ADJ
ajst-25616	109	11	tool	tool	NOUN
ajst-25616	109	12	,	,	PUNCT
ajst-25616	109	13	and	and	CCONJ
ajst-25616	109	14	chopchop	chopchop	NOUN
ajst-25616	109	15	.	.	PUNCT
ajst-25616	110	1	you	you	PRON
ajst-25616	110	2	can	can	AUX
ajst-25616	110	3	further	far	ADV
ajst-25616	110	4	evaluate	evaluate	VERB
ajst-25616	110	5	and	and	CCONJ
ajst-25616	110	6	select	select	VERB
ajst-25616	110	7	the	the	DET
ajst-25616	110	8	crrna	crrna	NOUN
ajst-25616	110	9	with	with	ADP
ajst-25616	110	10	the	the	DET
ajst-25616	110	11	highest	high	ADJ
ajst-25616	110	12	predicted	predict	VERB
ajst-25616	110	13	target	target	NOUN
ajst-25616	110	14	performance	performance	NOUN
ajst-25616	110	15	and	and	CCONJ
ajst-25616	110	16	the	the	DET
ajst-25616	110	17	lowest	low	ADJ
ajst-25616	110	18	off	off	ADP
ajst-25616	110	19	-	-	PUNCT
ajst-25616	110	20	target	target	NOUN
ajst-25616	110	21	activity	activity	NOUN
ajst-25616	110	22	without	without	ADP
ajst-25616	110	23	common	common	ADJ
ajst-25616	110	24	single	single	ADJ
ajst-25616	110	25	nucleotide	nucleotide	NOUN
ajst-25616	110	26	polymorphisms	polymorphism	NOUN
ajst-25616	110	27	(	(	PUNCT
ajst-25616	110	28	snps	snps	PROPN
ajst-25616	110	29	)	)	PUNCT
ajst-25616	110	30	using	use	VERB
ajst-25616	110	31	the	the	DET
ajst-25616	110	32	idt	idt	ADJ
ajst-25616	110	33	crispr	crispr	ADJ
ajst-25616	110	34	-	-	PUNCT
ajst-25616	110	35	cas9	cas9	NOUN
ajst-25616	110	36	crrna	crrna	NOUN
ajst-25616	110	37	checker	checker	NOUN
ajst-25616	110	38	(	(	PUNCT
ajst-25616	110	39	https://sg.idtdna	https://sg.idtdna	NOUN
ajst-25616	110	40	.	.	PUNCT
ajst-25616	110	41	com	com	NOUN
ajst-25616	110	42	/	/	SYM
ajst-25616	110	43	site/	site/	NUM
ajst-25616	110	44	order/	order/	NUM
ajst-25616	110	45	designtool/	designtool/	NUM
ajst-25616	110	46	index/	index/	NUM
ajst-25616	110	47	crispr	crispr	ADJ
ajst-25616	110	48	_	_	NOUN
ajst-25616	110	49	sequence	sequence	NOUN
ajst-25616	110	50	)	)	PUNCT
ajst-25616	111	1	[	[	X
ajst-25616	111	2	29	29	NUM
ajst-25616	111	3	]	]	PUNCT
ajst-25616	111	4	.	.	PUNCT
ajst-25616	112	1	based	base	VERB
ajst-25616	112	2	on	on	ADP
ajst-25616	112	3	the	the	DET
ajst-25616	112	4	ont	ont	NOUN
ajst-25616	112	5	(	(	PUNCT
ajst-25616	112	6	oxford	oxford	PROPN
ajst-25616	112	7	nanopore	nanopore	ADJ
ajst-25616	112	8	technologies	technology	NOUN
ajst-25616	112	9	)	)	PUNCT
ajst-25616	112	10	protocol	protocol	NOUN
ajst-25616	112	11	,	,	PUNCT
ajst-25616	112	12	which	which	PRON
ajst-25616	112	13	can	can	AUX
ajst-25616	112	14	be	be	AUX
ajst-25616	112	15	obtained	obtain	VERB
ajst-25616	112	16	from	from	ADP
ajst-25616	112	17	the	the	DET
ajst-25616	112	18	ont	ont	PROPN
ajst-25616	112	19	community	community	NOUN
ajst-25616	112	20	,	,	PUNCT
ajst-25616	112	21	one	one	PRON
ajst-25616	112	22	can	can	AUX
ajst-25616	112	23	acquire	acquire	VERB
ajst-25616	112	24	a	a	DET
ajst-25616	112	25	sequencing	sequence	VERB
ajst-25616	112	26	library	library	NOUN
ajst-25616	112	27	.	.	PUNCT
ajst-25616	113	1	alternatively	alternatively	ADV
ajst-25616	113	2	,	,	PUNCT
ajst-25616	113	3	a	a	DET
ajst-25616	113	4	method	method	NOUN
ajst-25616	113	5	involving	involve	VERB
ajst-25616	113	6	initial	initial	ADJ
ajst-25616	113	7	dephosphorylation	dephosphorylation	NOUN
ajst-25616	113	8	,	,	PUNCT
ajst-25616	113	9	followed	follow	VERB
ajst-25616	113	10	by	by	ADP
ajst-25616	113	11	the	the	DET
ajst-25616	113	12	addition	addition	NOUN
ajst-25616	113	13	of	of	ADP
ajst-25616	113	14	the	the	DET
ajst-25616	113	15	designed	design	VERB
ajst-25616	113	16	cas9	cas9	NOUN
ajst-25616	113	17	/	/	SYM
ajst-25616	113	18	grna	grna	NOUN
ajst-25616	113	19	complex	complex	NOUN
ajst-25616	113	20	,	,	PUNCT
ajst-25616	113	21	taq	taq	NOUN
ajst-25616	113	22	polymerase	polymerase	NOUN
ajst-25616	113	23	,	,	PUNCT
ajst-25616	113	24	and	and	CCONJ
ajst-25616	113	25	then	then	ADV
ajst-25616	113	26	proceeding	proceed	VERB
ajst-25616	113	27	with	with	ADP
ajst-25616	113	28	a	a	DET
ajst-25616	113	29	-	-	PUNCT
ajst-25616	113	30	tailing	tailing	NOUN
ajst-25616	113	31	of	of	ADP
ajst-25616	113	32	dna	dna	PROPN
ajst-25616	113	33	ends	end	NOUN
ajst-25616	113	34	can	can	AUX
ajst-25616	113	35	also	also	ADV
ajst-25616	113	36	achieve	achieve	VERB
ajst-25616	113	37	enrichment	enrichment	NOUN
ajst-25616	113	38	.	.	PUNCT
ajst-25616	114	1	after	after	ADP
ajst-25616	114	2	completing	complete	VERB
ajst-25616	114	3	double	double	ADJ
ajst-25616	114	4	or	or	CCONJ
ajst-25616	114	5	multiple	multiple	ADJ
ajst-25616	114	6	cutting	cutting	NOUN
ajst-25616	114	7	of	of	ADP
ajst-25616	114	8	the	the	DET
ajst-25616	114	9	double	double	ADJ
ajst-25616	114	10	strands	strand	NOUN
ajst-25616	114	11	,	,	PUNCT
ajst-25616	114	12	sequencing	sequencing	NOUN
ajst-25616	114	13	is	be	AUX
ajst-25616	114	14	carried	carry	VERB
ajst-25616	114	15	out	out	ADP
ajst-25616	114	16	.	.	PUNCT
ajst-25616	115	1	4.3.1.2	4.3.1.2	NUM
ajst-25616	115	2	data	datum	NOUN
ajst-25616	115	3	processing	processing	NOUN
ajst-25616	115	4	and	and	CCONJ
ajst-25616	115	5	analysis	analysis	NOUN
ajst-25616	115	6	raw	raw	ADJ
ajst-25616	115	7	sequencing	sequencing	NOUN
ajst-25616	115	8	signals	signal	NOUN
ajst-25616	115	9	were	be	AUX
ajst-25616	115	10	base	base	NOUN
ajst-25616	115	11	-	-	PUNCT
ajst-25616	115	12	called	call	VERB
ajst-25616	115	13	and	and	CCONJ
ajst-25616	115	14	transformed	transform	VERB
ajst-25616	115	15	into	into	ADP
ajst-25616	115	16	fastq	fastq	ADJ
ajst-25616	115	17	format	format	NOUN
ajst-25616	115	18	reads	read	NOUN
ajst-25616	115	19	,	,	PUNCT
ajst-25616	115	20	and	and	CCONJ
ajst-25616	115	21	we	we	PRON
ajst-25616	115	22	can	can	AUX
ajst-25616	115	23	utilize	utilize	VERB
ajst-25616	115	24	guppy	guppy	NOUN
ajst-25616	115	25	for	for	ADP
ajst-25616	115	26	performing	perform	VERB
ajst-25616	115	27	the	the	DET
ajst-25616	115	28	basecalling	basecalling	NOUN
ajst-25616	115	29	.	.	PUNCT
ajst-25616	116	1	minimap2	minimap2	NOUN
ajst-25616	116	2	can	can	AUX
ajst-25616	116	3	be	be	AUX
ajst-25616	116	4	employed	employ	VERB
ajst-25616	116	5	to	to	PART
ajst-25616	116	6	align	align	VERB
ajst-25616	116	7	the	the	DET
ajst-25616	116	8	reads	read	NOUN
ajst-25616	116	9	with	with	ADP
ajst-25616	116	10	the	the	DET
ajst-25616	116	11	grch38	grch38	PROPN
ajst-25616	116	12	human	human	ADJ
ajst-25616	116	13	reference	reference	NOUN
ajst-25616	116	14	genome	genome	NOUN
ajst-25616	116	15	,	,	PUNCT
ajst-25616	116	16	and	and	CCONJ
ajst-25616	116	17	then	then	ADV
ajst-25616	116	18	categorize	categorize	VERB
ajst-25616	116	19	them	they	PRON
ajst-25616	116	20	using	use	VERB
ajst-25616	116	21	samtools	samtool	NOUN
ajst-25616	116	22	or	or	CCONJ
ajst-25616	116	23	the	the	DET
ajst-25616	116	24	'	'	PUNCT
ajst-25616	116	25	bincov	bincov	NOUN
ajst-25616	116	26	'	'	PUNCT
ajst-25616	116	27	script	script	NOUN
ajst-25616	116	28	from	from	ADP
ajst-25616	116	29	the	the	DET
ajst-25616	116	30	survivor	survivor	NOUN
ajst-25616	116	31	software	software	NOUN
ajst-25616	116	32	package	package	NOUN
ajst-25616	116	33	.	.	PUNCT
ajst-25616	117	1	alignments	alignment	NOUN
ajst-25616	117	2	can	can	AUX
ajst-25616	117	3	be	be	AUX
ajst-25616	117	4	visualized	visualize	VERB
ajst-25616	117	5	on	on	ADP
ajst-25616	117	6	the	the	DET
ajst-25616	117	7	integrative	integrative	ADJ
ajst-25616	117	8	genomics	genomics	NOUN
ajst-25616	117	9	viewer	viewer	NOUN
ajst-25616	117	10	(	(	PUNCT
ajst-25616	117	11	igv	igv	NOUN
ajst-25616	117	12	)	)	PUNCT
ajst-25616	118	1	[	[	X
ajst-25616	118	2	29,30	29,30	NUM
ajst-25616	118	3	]	]	PUNCT
ajst-25616	118	4	.	.	PUNCT
ajst-25616	119	1	specifically	specifically	ADV
ajst-25616	119	2	,	,	PUNCT
ajst-25616	119	3	during	during	ADP
ajst-25616	119	4	diagnostic	diagnostic	ADJ
ajst-25616	119	5	sequencing	sequencing	NOUN
ajst-25616	119	6	for	for	ADP
ajst-25616	119	7	187	187	NUM
ajst-25616	119	8	familial	familial	ADJ
ajst-25616	119	9	hypercholesterolemia	hypercholesterolemia	NOUN
ajst-25616	119	10	[	[	X
ajst-25616	119	11	30	30	NUM
ajst-25616	119	12	]	]	PUNCT
ajst-25616	119	13	,	,	PUNCT
ajst-25616	119	14	considering	consider	VERB
ajst-25616	119	15	the	the	DET
ajst-25616	119	16	off	off	ADP
ajst-25616	119	17	-	-	PUNCT
ajst-25616	119	18	target	target	NOUN
ajst-25616	119	19	effects	effect	NOUN
ajst-25616	119	20	of	of	ADP
ajst-25616	119	21	the	the	DET
ajst-25616	119	22	cas9	cas9	NOUN
ajst-25616	119	23	complex	complex	NOUN
ajst-25616	119	24	's	's	PART
ajst-25616	119	25	nonspecific	nonspecific	ADJ
ajst-25616	119	26	binding	binding	NOUN
ajst-25616	119	27	and	and	CCONJ
ajst-25616	119	28	the	the	DET
ajst-25616	119	29	physical	physical	ADJ
ajst-25616	119	30	shearing	shearing	NOUN
ajst-25616	119	31	forces	force	NOUN
ajst-25616	119	32	during	during	ADP
ajst-25616	119	33	the	the	DET
ajst-25616	119	34	experiment	experiment	NOUN
ajst-25616	119	35	that	that	PRON
ajst-25616	119	36	may	may	AUX
ajst-25616	119	37	damage	damage	VERB
ajst-25616	119	38	gdna	gdna	ADJ
ajst-25616	119	39	molecules	molecule	NOUN
ajst-25616	119	40	outside	outside	ADP
ajst-25616	119	41	the	the	DET
ajst-25616	119	42	region	region	NOUN
ajst-25616	119	43	of	of	ADP
ajst-25616	119	44	interest	interest	NOUN
ajst-25616	119	45	(	(	PUNCT
ajst-25616	119	46	roi	roi	NOUN
ajst-25616	119	47	)	)	PUNCT
ajst-25616	119	48	,	,	PUNCT
ajst-25616	119	49	a	a	DET
ajst-25616	119	50	unique	unique	ADJ
ajst-25616	119	51	method	method	NOUN
ajst-25616	119	52	for	for	ADP
ajst-25616	119	53	calculating	calculate	VERB
ajst-25616	119	54	coverage	coverage	NOUN
ajst-25616	119	55	was	be	AUX
ajst-25616	119	56	devised	devise	VERB
ajst-25616	119	57	.	.	PUNCT
ajst-25616	120	1	in	in	ADP
ajst-25616	120	2	this	this	DET
ajst-25616	120	3	context	context	NOUN
ajst-25616	120	4	,	,	PUNCT
ajst-25616	120	5	"	"	PUNCT
ajst-25616	120	6	off	off	ADP
ajst-25616	120	7	-	-	PUNCT
ajst-25616	120	8	targets	target	NOUN
ajst-25616	120	9	"	"	PUNCT
ajst-25616	120	10	are	be	AUX
ajst-25616	120	11	defined	define	VERB
ajst-25616	120	12	as	as	ADP
ajst-25616	120	13	regions	region	NOUN
ajst-25616	120	14	outside	outside	ADP
ajst-25616	120	15	the	the	DET
ajst-25616	120	16	regions	region	NOUN
ajst-25616	120	17	of	of	ADP
ajst-25616	120	18	interest	interest	NOUN
ajst-25616	120	19	(	(	PUNCT
ajst-25616	120	20	rois	rois	PROPN
ajst-25616	120	21	)	)	PUNCT
ajst-25616	120	22	that	that	PRON
ajst-25616	120	23	exhibit	exhibit	VERB
ajst-25616	120	24	a	a	DET
ajst-25616	120	25	spatial	spatial	ADJ
ajst-25616	120	26	deviation	deviation	NOUN
ajst-25616	120	27	exceeding	exceed	VERB
ajst-25616	120	28	1000	1000	NUM
ajst-25616	120	29	base	base	NOUN
ajst-25616	120	30	pairs	pair	NOUN
ajst-25616	120	31	(	(	PUNCT
ajst-25616	120	32	bp	bp	PROPN
ajst-25616	120	33	)	)	PUNCT
ajst-25616	120	34	and	and	CCONJ
ajst-25616	120	35	possess	possess	VERB
ajst-25616	120	36	a	a	DET
ajst-25616	120	37	sequencing	sequence	VERB
ajst-25616	120	38	depth	depth	NOUN
ajst-25616	120	39	or	or	CCONJ
ajst-25616	120	40	coverage	coverage	NOUN
ajst-25616	120	41	greater	great	ADJ
ajst-25616	120	42	than	than	ADP
ajst-25616	120	43	25	25	NUM
ajst-25616	120	44	-	-	NOUN
ajst-25616	120	45	fold	fold	ADJ
ajst-25616	120	46	.	.	PUNCT
ajst-25616	121	1	to	to	PART
ajst-25616	121	2	identify	identify	VERB
ajst-25616	121	3	these	these	DET
ajst-25616	121	4	"	"	PUNCT
ajst-25616	121	5	offtarget	offtarget	NOUN
ajst-25616	121	6	"	"	PUNCT
ajst-25616	121	7	candidates	candidate	NOUN
ajst-25616	121	8	,	,	PUNCT
ajst-25616	121	9	we	we	PRON
ajst-25616	121	10	can	can	AUX
ajst-25616	121	11	use	use	VERB
ajst-25616	121	12	the	the	DET
ajst-25616	121	13	survivor	survivor	NOUN
ajst-25616	121	14	tool	tool	NOUN
ajst-25616	121	15	.	.	PUNCT
ajst-25616	122	1	subsequently	subsequently	ADV
ajst-25616	122	2	,	,	PUNCT
ajst-25616	122	3	to	to	PART
ajst-25616	122	4	gain	gain	VERB
ajst-25616	122	5	insights	insight	NOUN
ajst-25616	122	6	into	into	ADP
ajst-25616	122	7	the	the	DET
ajst-25616	122	8	enrichment	enrichment	NOUN
ajst-25616	122	9	efficiency	efficiency	NOUN
ajst-25616	122	10	of	of	ADP
ajst-25616	122	11	the	the	DET
ajst-25616	122	12	intended	intend	VERB
ajst-25616	122	13	targets	target	NOUN
ajst-25616	122	14	,	,	PUNCT
ajst-25616	122	15	the	the	DET
ajst-25616	122	16	coverage	coverage	NOUN
ajst-25616	122	17	levels	level	NOUN
ajst-25616	122	18	within	within	ADP
ajst-25616	122	19	rois	rois	PROPN
ajst-25616	122	20	,	,	PUNCT
ajst-25616	122	21	"	"	PUNCT
ajst-25616	122	22	offtarget	offtarget	NOUN
ajst-25616	122	23	"	"	PUNCT
ajst-25616	122	24	sites	site	NOUN
ajst-25616	122	25	,	,	PUNCT
ajst-25616	122	26	as	as	ADV
ajst-25616	122	27	well	well	ADV
ajst-25616	122	28	as	as	ADP
ajst-25616	122	29	across	across	ADP
ajst-25616	122	30	the	the	DET
ajst-25616	122	31	entire	entire	ADJ
ajst-25616	122	32	genome	genome	NOUN
ajst-25616	122	33	,	,	PUNCT
ajst-25616	122	34	were	be	AUX
ajst-25616	122	35	quantified	quantify	VERB
ajst-25616	122	36	utilizing	utilize	VERB
ajst-25616	122	37	the	the	DET
ajst-25616	122	38	samtools	samtools	PROPN
ajst-25616	122	39	software	software	NOUN
ajst-25616	122	40	package	package	NOUN
ajst-25616	122	41	.	.	PUNCT
ajst-25616	123	1	specifically	specifically	ADV
ajst-25616	123	2	,	,	PUNCT
ajst-25616	123	3	the	the	DET
ajst-25616	123	4	on	on	ADP
ajst-25616	123	5	-	-	PUNCT
ajst-25616	123	6	target	target	NOUN
ajst-25616	123	7	ratio	ratio	NOUN
ajst-25616	123	8	,	,	PUNCT
ajst-25616	123	9	was	be	AUX
ajst-25616	123	10	derived	derive	VERB
ajst-25616	123	11	by	by	ADP
ajst-25616	123	12	dividing	divide	VERB
ajst-25616	123	13	the	the	DET
ajst-25616	123	14	number	number	NOUN
ajst-25616	123	15	of	of	ADP
ajst-25616	123	16	on	on	ADP
ajst-25616	123	17	-	-	PUNCT
ajst-25616	123	18	target	target	NOUN
ajst-25616	123	19	reads	read	NOUN
ajst-25616	123	20	by	by	ADP
ajst-25616	123	21	the	the	DET
ajst-25616	123	22	number	number	NOUN
ajst-25616	123	23	of	of	ADP
ajst-25616	123	24	total	total	ADJ
ajst-25616	123	25	reads	read	NOUN
ajst-25616	123	26	generated	generate	VERB
ajst-25616	123	27	in	in	ADP
ajst-25616	123	28	the	the	DET
ajst-25616	123	29	experiment	experiment	NOUN
ajst-25616	123	30	[	[	X
ajst-25616	123	31	30	30	NUM
ajst-25616	123	32	]	]	PUNCT
ajst-25616	123	33	.	.	PUNCT
ajst-25616	124	1	4.3.1.3	4.3.1.3	NUM
ajst-25616	124	2	cas9	cas9	NOUN
ajst-25616	124	3	tiling	tile	VERB
ajst-25616	124	4	related	relate	VERB
ajst-25616	124	5	methods	method	NOUN
ajst-25616	124	6	when	when	SCONJ
ajst-25616	124	7	cutting	cut	VERB
ajst-25616	124	8	certain	certain	ADJ
ajst-25616	124	9	target	target	NOUN
ajst-25616	124	10	dna	dna	NOUN
ajst-25616	124	11	or	or	CCONJ
ajst-25616	124	12	rna	rna	NOUN
ajst-25616	124	13	sequences	sequence	NOUN
ajst-25616	124	14	,	,	PUNCT
ajst-25616	124	15	there	there	PRON
ajst-25616	124	16	is	be	VERB
ajst-25616	124	17	a	a	DET
ajst-25616	124	18	risk	risk	NOUN
ajst-25616	124	19	of	of	ADP
ajst-25616	124	20	losing	lose	VERB
ajst-25616	124	21	or	or	CCONJ
ajst-25616	124	22	depleting	deplete	VERB
ajst-25616	124	23	the	the	DET
ajst-25616	124	24	fragments	fragment	NOUN
ajst-25616	124	25	due	due	ADP
ajst-25616	124	26	to	to	ADP
ajst-25616	124	27	their	their	PRON
ajst-25616	124	28	small	small	ADJ
ajst-25616	124	29	size	size	NOUN
ajst-25616	124	30	after	after	ADP
ajst-25616	124	31	cutting	cut	VERB
ajst-25616	124	32	.	.	PUNCT
ajst-25616	125	1	research	research	NOUN
ajst-25616	125	2	has	have	AUX
ajst-25616	125	3	shown	show	VERB
ajst-25616	125	4	that	that	SCONJ
ajst-25616	125	5	without	without	ADP
ajst-25616	125	6	the	the	DET
ajst-25616	125	7	enrichment	enrichment	NOUN
ajst-25616	125	8	using	use	VERB
ajst-25616	125	9	the	the	DET
ajst-25616	125	10	ont	ont	NOUN
ajst-25616	125	11	(	(	PUNCT
ajst-25616	125	12	oxford	oxford	PROPN
ajst-25616	125	13	nanopore	nanopore	ADJ
ajst-25616	125	14	technologies	technology	NOUN
ajst-25616	125	15	)	)	PUNCT
ajst-25616	125	16	platform	platform	NOUN
ajst-25616	125	17	,	,	PUNCT
ajst-25616	125	18	a	a	DET
ajst-25616	125	19	method	method	NOUN
ajst-25616	125	20	known	know	VERB
ajst-25616	125	21	as	as	ADP
ajst-25616	125	22	cas9	cas9	NOUN
ajst-25616	125	23	tiling	tile	VERB
ajst-25616	125	24	can	can	AUX
ajst-25616	125	25	be	be	AUX
ajst-25616	125	26	used	use	VERB
ajst-25616	125	27	to	to	PART
ajst-25616	125	28	enrich	enrich	VERB
ajst-25616	125	29	longer	long	ADJ
ajst-25616	125	30	targets	target	NOUN
ajst-25616	125	31	,	,	PUNCT
ajst-25616	125	32	which	which	PRON
ajst-25616	125	33	involves	involve	VERB
ajst-25616	125	34	targeted	target	VERB
ajst-25616	125	35	de	de	X
ajst-25616	125	36	novo	novo	NOUN
ajst-25616	125	37	assembly	assembly	NOUN
ajst-25616	125	38	to	to	PART
ajst-25616	125	39	accurately	accurately	ADV
ajst-25616	125	40	reconstruct	reconstruct	VERB
ajst-25616	125	41	the	the	DET
ajst-25616	125	42	genome	genome	NOUN
ajst-25616	125	43	region	region	NOUN
ajst-25616	125	44	of	of	ADP
ajst-25616	125	45	interest	interest	NOUN
ajst-25616	126	1	[	[	X
ajst-25616	126	2	31	31	NUM
ajst-25616	126	3	]	]	PUNCT
ajst-25616	126	4	.	.	PUNCT
ajst-25616	127	1	unlike	unlike	ADP
ajst-25616	127	2	conventional	conventional	ADJ
ajst-25616	127	3	cas9	cas9	NOUN
ajst-25616	127	4	-	-	PUNCT
ajst-25616	127	5	mediated	mediate	VERB
ajst-25616	127	6	nanopore	nanopore	ADV
ajst-25616	127	7	sequencing	sequencing	NOUN
ajst-25616	127	8	,	,	PUNCT
ajst-25616	127	9	the	the	DET
ajst-25616	127	10	cas9	cas9	NOUN
ajst-25616	127	11	tiling	tile	VERB
ajst-25616	127	12	method	method	NOUN
ajst-25616	127	13	has	have	AUX
ajst-25616	127	14	been	be	AUX
ajst-25616	127	15	modified	modify	VERB
ajst-25616	127	16	for	for	ADP
ajst-25616	127	17	sequencing	sequence	VERB
ajst-25616	127	18	extremely	extremely	ADV
ajst-25616	127	19	lengthy	lengthy	ADJ
ajst-25616	127	20	targets	target	NOUN
ajst-25616	127	21	and	and	CCONJ
ajst-25616	127	22	was	be	AUX
ajst-25616	127	23	utilized	utilize	VERB
ajst-25616	127	24	for	for	ADP
ajst-25616	127	25	the	the	DET
ajst-25616	127	26	reconstruction	reconstruction	NOUN
ajst-25616	127	27	of	of	ADP
ajst-25616	127	28	this	this	DET
ajst-25616	127	29	specific	specific	ADJ
ajst-25616	127	30	area	area	NOUN
ajst-25616	127	31	in	in	ADP
ajst-25616	127	32	the	the	DET
ajst-25616	127	33	non	non	ADJ
ajst-25616	127	34	-	-	ADJ
ajst-25616	127	35	shattering	shattering	ADJ
ajst-25616	127	36	p.	p.	NOUN
ajst-25616	127	37	vulgaris	vulgaris	NOUN
ajst-25616	127	38	cultivar	cultivar	NOUN
ajst-25616	127	39	midas	midas	PROPN
ajst-25616	127	40	.	.	PUNCT
ajst-25616	128	1	in	in	ADP
ajst-25616	128	2	the	the	DET
ajst-25616	128	3	research	research	NOUN
ajst-25616	128	4	on	on	ADP
ajst-25616	128	5	the	the	DET
ajst-25616	128	6	common	common	ADJ
ajst-25616	128	7	bean	bean	NOUN
ajst-25616	128	8	's	's	PART
ajst-25616	128	9	genome	genome	NOUN
ajst-25616	128	10	[	[	X
ajst-25616	128	11	32	32	NUM
ajst-25616	128	12	]	]	PUNCT
ajst-25616	128	13	,	,	PUNCT
ajst-25616	128	14	the	the	DET
ajst-25616	128	15	precision	precision	NOUN
ajst-25616	128	16	of	of	ADP
ajst-25616	128	17	the	the	DET
ajst-25616	128	18	region	region	NOUN
ajst-25616	128	19	of	of	ADP
ajst-25616	128	20	interest	interest	NOUN
ajst-25616	128	21	(	(	PUNCT
ajst-25616	128	22	roi	roi	NOUN
ajst-25616	128	23	)	)	PUNCT
ajst-25616	128	24	assembly	assembly	NOUN
ajst-25616	128	25	,	,	PUNCT
ajst-25616	128	26	which	which	PRON
ajst-25616	128	27	was	be	AUX
ajst-25616	128	28	produced	produce	VERB
ajst-25616	128	29	using	use	VERB
ajst-25616	128	30	the	the	DET
ajst-25616	128	31	cas9	cas9	NOUN
ajst-25616	128	32	tiling	tile	VERB
ajst-25616	128	33	technique	technique	NOUN
ajst-25616	128	34	,	,	PUNCT
ajst-25616	128	35	was	be	AUX
ajst-25616	128	36	validated	validate	VERB
ajst-25616	128	37	against	against	ADP
ajst-25616	128	38	the	the	DET
ajst-25616	128	39	traditional	traditional	ADJ
ajst-25616	128	40	de	de	X
ajst-25616	128	41	novo	novo	NOUN
ajst-25616	128	42	assembly	assembly	NOUN
ajst-25616	128	43	of	of	ADP
ajst-25616	128	44	the	the	DET
ajst-25616	128	45	entire	entire	ADJ
ajst-25616	128	46	genome	genome	NOUN
ajst-25616	128	47	.	.	PUNCT
ajst-25616	129	1	the	the	DET
ajst-25616	129	2	cas9	cas9	NOUN
ajst-25616	129	3	tiling	tile	VERB
ajst-25616	129	4	technique	technique	NOUN
ajst-25616	129	5	,	,	PUNCT
ajst-25616	129	6	by	by	ADP
ajst-25616	129	7	assembling	assemble	VERB
ajst-25616	129	8	a	a	DET
ajst-25616	129	9	genomic	genomic	ADJ
ajst-25616	129	10	region	region	NOUN
ajst-25616	129	11	into	into	ADP
ajst-25616	129	12	a	a	DET
ajst-25616	129	13	continuous	continuous	ADJ
ajst-25616	129	14	sequence	sequence	NOUN
ajst-25616	129	15	,	,	PUNCT
ajst-25616	129	16	achieves	achieve	VERB
ajst-25616	129	17	high	high	ADJ
ajst-25616	129	18	consistency	consistency	NOUN
ajst-25616	129	19	compared	compare	VERB
ajst-25616	129	20	to	to	ADP
ajst-25616	129	21	traditional	traditional	ADJ
ajst-25616	129	22	long	long	ADV
ajst-25616	129	23	-	-	PUNCT
ajst-25616	129	24	read	read	VERB
ajst-25616	129	25	wgs	wgs	NOUN
ajst-25616	129	26	methods	method	NOUN
ajst-25616	129	27	while	while	SCONJ
ajst-25616	129	28	improving	improve	VERB
ajst-25616	129	29	the	the	DET
ajst-25616	129	30	accuracy	accuracy	NOUN
ajst-25616	129	31	of	of	ADP
ajst-25616	129	32	variant	variant	ADJ
ajst-25616	129	33	detection	detection	NOUN
ajst-25616	129	34	.	.	PUNCT
ajst-25616	130	1	utilizing	utilize	VERB
ajst-25616	130	2	the	the	DET
ajst-25616	130	3	regions	region	NOUN
ajst-25616	130	4	reconstructed	reconstruct	VERB
ajst-25616	130	5	by	by	ADP
ajst-25616	130	6	cas9	cas9	NOUN
ajst-25616	130	7	tiling	tiling	NOUN
ajst-25616	130	8	,	,	PUNCT
ajst-25616	130	9	it	it	PRON
ajst-25616	130	10	is	be	AUX
ajst-25616	130	11	possible	possible	ADJ
ajst-25616	130	12	to	to	AUX
ajst-25616	130	13	more	more	ADV
ajst-25616	130	14	precisely	precisely	ADV
ajst-25616	130	15	locate	locate	ADJ
ajst-25616	130	16	read	read	VERB
ajst-25616	130	17	sequences	sequence	NOUN
ajst-25616	130	18	within	within	ADP
ajst-25616	130	19	specific	specific	ADJ
ajst-25616	130	20	varieties	variety	NOUN
ajst-25616	130	21	,	,	PUNCT
ajst-25616	130	22	facilitating	facilitate	VERB
ajst-25616	130	23	the	the	DET
ajst-25616	130	24	accurate	accurate	ADJ
ajst-25616	130	25	calling	calling	NOUN
ajst-25616	130	26	of	of	ADP
ajst-25616	130	27	variations	variation	NOUN
ajst-25616	130	28	,	,	PUNCT
ajst-25616	130	29	which	which	PRON
ajst-25616	130	30	is	be	AUX
ajst-25616	130	31	suitable	suitable	ADJ
ajst-25616	130	32	for	for	ADP
ajst-25616	130	33	gwas	gwas	PROPN
ajst-25616	130	34	(	(	PUNCT
ajst-25616	130	35	genome	genome	NOUN
ajst-25616	130	36	-	-	PUNCT
ajst-25616	130	37	wide	wide	ADJ
ajst-25616	130	38	association	association	NOUN
ajst-25616	130	39	studies	study	NOUN
ajst-25616	130	40	)	)	PUNCT
ajst-25616	130	41	and	and	CCONJ
ajst-25616	130	42	fine	fine	ADJ
ajst-25616	130	43	-	-	PUNCT
ajst-25616	130	44	mapping	mapping	NOUN
ajst-25616	130	45	studies	study	NOUN
ajst-25616	130	46	related	relate	VERB
ajst-25616	130	47	to	to	ADP
ajst-25616	130	48	given	give	VERB
ajst-25616	130	49	phenotypes	phenotype	NOUN
ajst-25616	130	50	.	.	PUNCT
ajst-25616	131	1	additionally	additionally	ADV
ajst-25616	131	2	,	,	PUNCT
ajst-25616	131	3	integrating	integrate	VERB
ajst-25616	131	4	these	these	DET
ajst-25616	131	5	reconstructed	reconstruct	VERB
ajst-25616	131	6	sequences	sequence	NOUN
ajst-25616	131	7	into	into	ADP
ajst-25616	131	8	the	the	DET
ajst-25616	131	9	reference	reference	NOUN
ajst-25616	131	10	genome	genome	NOUN
ajst-25616	131	11	can	can	AUX
ajst-25616	131	12	enhance	enhance	VERB
ajst-25616	131	13	the	the	DET
ajst-25616	131	14	genotyping	genotyping	NOUN
ajst-25616	131	15	capability	capability	NOUN
ajst-25616	131	16	for	for	ADP
ajst-25616	131	17	short	short	ADJ
ajst-25616	131	18	-	-	PUNCT
ajst-25616	131	19	read	read	NOUN
ajst-25616	131	20	sequencing	sequence	VERB
ajst-25616	131	21	data	datum	NOUN
ajst-25616	131	22	of	of	ADP
ajst-25616	131	23	inbred	inbreed	VERB
ajst-25616	131	24	line	line	NOUN
ajst-25616	131	25	individuals	individual	NOUN
ajst-25616	131	26	,	,	PUNCT
ajst-25616	131	27	providing	provide	VERB
ajst-25616	131	28	new	new	ADJ
ajst-25616	131	29	strategies	strategy	NOUN
ajst-25616	131	30	for	for	ADP
ajst-25616	131	31	genomic	genomic	ADJ
ajst-25616	131	32	research	research	NOUN
ajst-25616	131	33	and	and	CCONJ
ajst-25616	131	34	molecular	molecular	ADJ
ajst-25616	131	35	breeding	breeding	NOUN
ajst-25616	131	36	.	.	PUNCT
ajst-25616	132	1	4.3.2	4.3.2	X
ajst-25616	132	2	.	.	PUNCT
ajst-25616	133	1	cas12a	cas12a	NOUN
ajst-25616	133	2	-	-	PUNCT
ajst-25616	133	3	mediated	mediate	VERB
ajst-25616	133	4	nanopore	nanopore	ADV
ajst-25616	133	5	sequencing	sequencing	NOUN
ajst-25616	133	6	as	as	SCONJ
ajst-25616	133	7	previously	previously	ADV
ajst-25616	133	8	mentioned	mention	VERB
ajst-25616	133	9	,	,	PUNCT
ajst-25616	133	10	in	in	ADP
ajst-25616	133	11	current	current	ADJ
ajst-25616	133	12	research	research	NOUN
ajst-25616	133	13	on	on	ADP
ajst-25616	133	14	crispr	crispr	ADJ
ajst-25616	133	15	/	/	SYM
ajst-25616	133	16	cas9	cas9	NOUN
ajst-25616	133	17	-	-	PUNCT
ajst-25616	133	18	mediated	mediate	VERB
ajst-25616	133	19	nanopore	nanopore	ADV
ajst-25616	133	20	sequencing	sequence	VERB
ajst-25616	133	21	,	,	PUNCT
ajst-25616	133	22	there	there	PRON
ajst-25616	133	23	are	be	VERB
ajst-25616	133	24	often	often	ADV
ajst-25616	133	25	sequencing	sequence	VERB
ajst-25616	133	26	errors	error	NOUN
ajst-25616	133	27	caused	cause	VERB
ajst-25616	133	28	by	by	ADP
ajst-25616	133	29	off	off	ADP
ajst-25616	133	30	-	-	PUNCT
ajst-25616	133	31	target	target	NOUN
ajst-25616	133	32	effects	effect	NOUN
ajst-25616	133	33	,	,	PUNCT
ajst-25616	133	34	leading	lead	VERB
ajst-25616	133	35	to	to	ADP
ajst-25616	133	36	inaccuracies	inaccuracy	NOUN
ajst-25616	133	37	in	in	ADP
ajst-25616	133	38	the	the	DET
ajst-25616	133	39	results	result	NOUN
ajst-25616	133	40	.	.	PUNCT
ajst-25616	134	1	however	however	ADV
ajst-25616	134	2	,	,	PUNCT
ajst-25616	134	3	evidence	evidence	NOUN
ajst-25616	134	4	suggests	suggest	VERB
ajst-25616	134	5	that	that	SCONJ
ajst-25616	134	6	cas12a	cas12a	NOUN
ajst-25616	134	7	,	,	PUNCT
ajst-25616	134	8	previously	previously	ADV
ajst-25616	134	9	known	know	VERB
ajst-25616	134	10	as	as	ADP
ajst-25616	134	11	cpf1	cpf1	NOUN
ajst-25616	134	12	,	,	PUNCT
ajst-25616	134	13	may	may	AUX
ajst-25616	134	14	have	have	AUX
ajst-25616	134	15	enhanced	enhance	VERB
ajst-25616	134	16	features	feature	NOUN
ajst-25616	134	17	,	,	PUNCT
ajst-25616	134	18	including	include	VERB
ajst-25616	134	19	a	a	DET
ajst-25616	134	20	lower	low	ADJ
ajst-25616	134	21	incidence	incidence	NOUN
ajst-25616	134	22	of	of	ADP
ajst-25616	134	23	off	off	ADP
ajst-25616	134	24	-	-	PUNCT
ajst-25616	134	25	target	target	NOUN
ajst-25616	134	26	effects	effect	NOUN
ajst-25616	134	27	[	[	X
ajst-25616	134	28	3335	3335	NUM
ajst-25616	134	29	]	]	PUNCT
ajst-25616	134	30	,	,	PUNCT
ajst-25616	134	31	although	although	SCONJ
ajst-25616	134	32	this	this	PRON
ajst-25616	134	33	is	be	AUX
ajst-25616	134	34	still	still	ADV
ajst-25616	134	35	a	a	DET
ajst-25616	134	36	matter	matter	NOUN
ajst-25616	134	37	of	of	ADP
ajst-25616	134	38	debate	debate	NOUN
ajst-25616	134	39	[	[	X
ajst-25616	134	40	36	36	NUM
ajst-25616	134	41	]	]	PUNCT
ajst-25616	134	42	.	.	PUNCT
ajst-25616	135	1	moreover	moreover	ADV
ajst-25616	135	2	,	,	PUNCT
ajst-25616	135	3	the	the	DET
ajst-25616	135	4	nucleic	nucleic	ADJ
ajst-25616	135	5	acid	acid	NOUN
ajst-25616	135	6	recognition	recognition	NOUN
ajst-25616	135	7	capabilities	capability	NOUN
ajst-25616	135	8	of	of	ADP
ajst-25616	135	9	cas12a	cas12a	NOUN
ajst-25616	135	10	have	have	AUX
ajst-25616	135	11	also	also	ADV
ajst-25616	135	12	been	be	AUX
ajst-25616	135	13	utilized	utilize	VERB
ajst-25616	135	14	for	for	ADP
ajst-25616	135	15	diagnostic	diagnostic	ADJ
ajst-25616	135	16	applications	application	NOUN
ajst-25616	135	17	,	,	PUNCT
ajst-25616	135	18	notably	notably	ADV
ajst-25616	135	19	for	for	ADP
ajst-25616	135	20	the	the	DET
ajst-25616	135	21	detection	detection	NOUN
ajst-25616	135	22	of	of	ADP
ajst-25616	135	23	sars	sar	NOUN
ajst-25616	135	24	-	-	PUNCT
ajst-25616	135	25	cov-2	cov-2	NOUN
ajst-25616	135	26	genomic	genomic	NOUN
ajst-25616	135	27	rna	rna	NOUN
ajst-25616	136	1	[	[	X
ajst-25616	136	2	37	37	NUM
ajst-25616	136	3	]	]	PUNCT
ajst-25616	136	4	.	.	PUNCT
ajst-25616	137	1	specifically	specifically	ADV
ajst-25616	137	2	,	,	PUNCT
ajst-25616	137	3	the	the	DET
ajst-25616	137	4	realization	realization	NOUN
ajst-25616	137	5	of	of	ADP
ajst-25616	137	6	the	the	DET
ajst-25616	137	7	collateral	collateral	ADJ
ajst-25616	137	8	cleavage	cleavage	NOUN
ajst-25616	137	9	activity	activity	NOUN
ajst-25616	137	10	of	of	ADP
ajst-25616	137	11	cas	cas	PROPN
ajst-25616	137	12	proteins	protein	NOUN
ajst-25616	137	13	,	,	PUNCT
ajst-25616	137	14	including	include	VERB
ajst-25616	137	15	cas12	cas12	NOUN
ajst-25616	137	16	and	and	CCONJ
ajst-25616	137	17	cas13	cas13	PROPN
ajst-25616	137	18	,	,	PUNCT
ajst-25616	137	19	has	have	AUX
ajst-25616	137	20	facilitated	facilitate	VERB
ajst-25616	137	21	the	the	DET
ajst-25616	137	22	targeted	target	VERB
ajst-25616	137	23	detection	detection	NOUN
ajst-25616	137	24	of	of	ADP
ajst-25616	137	25	specific	specific	ADJ
ajst-25616	137	26	transcript	transcript	NOUN
ajst-25616	137	27	sequences	sequence	NOUN
ajst-25616	137	28	,	,	PUNCT
ajst-25616	137	29	yielding	yield	VERB
ajst-25616	137	30	observable	observable	ADJ
ajst-25616	137	31	signals	signal	NOUN
ajst-25616	137	32	[	[	X
ajst-25616	137	33	38	38	NUM
ajst-25616	137	34	]	]	PUNCT
ajst-25616	137	35	.	.	PUNCT
ajst-25616	138	1	the	the	DET
ajst-25616	138	2	cas12a	cas12a	ADJ
ajst-25616	138	3	protein	protein	NOUN
ajst-25616	138	4	is	be	AUX
ajst-25616	138	5	structured	structure	VERB
ajst-25616	138	6	as	as	ADP
ajst-25616	138	7	a	a	DET
ajst-25616	138	8	bi	bi	ADJ
ajst-25616	138	9	-	-	ADJ
ajst-25616	138	10	lobed	lobed	ADJ
ajst-25616	138	11	monomer	monomer	NOUN
ajst-25616	138	12	,	,	PUNCT
ajst-25616	138	13	comprising	comprise	VERB
ajst-25616	138	14	distinct	distinct	ADJ
ajst-25616	138	15	recognition	recognition	NOUN
ajst-25616	138	16	and	and	CCONJ
ajst-25616	138	17	nuclease	nuclease	NOUN
ajst-25616	138	18	domains	domain	NOUN
ajst-25616	138	19	.	.	PUNCT
ajst-25616	139	1	when	when	SCONJ
ajst-25616	139	2	a	a	DET
ajst-25616	139	3	cas12a	cas12a	ADJ
ajst-25616	139	4	enzyme	enzyme	NOUN
ajst-25616	139	5	complexes	complex	NOUN
ajst-25616	139	6	with	with	ADP
ajst-25616	139	7	a	a	DET
ajst-25616	139	8	crispr	crispr	ADJ
ajst-25616	139	9	rna	rna	NOUN
ajst-25616	139	10	(	(	PUNCT
ajst-25616	139	11	crrna	crrna	PROPN
ajst-25616	139	12	)	)	PUNCT
ajst-25616	139	13	,	,	PUNCT
ajst-25616	139	14	it	it	PRON
ajst-25616	139	15	scans	scan	VERB
ajst-25616	139	16	dna	dna	NOUN
ajst-25616	139	17	for	for	ADP
ajst-25616	139	18	a	a	DET
ajst-25616	139	19	complementary	complementary	ADJ
ajst-25616	139	20	target	target	NOUN
ajst-25616	139	21	sequence	sequence	NOUN
ajst-25616	139	22	.	.	PUNCT
ajst-25616	140	1	the	the	DET
ajst-25616	140	2	interaction	interaction	NOUN
ajst-25616	140	3	with	with	ADP
ajst-25616	140	4	the	the	DET
ajst-25616	140	5	target	target	NOUN
ajst-25616	140	6	is	be	AUX
ajst-25616	140	7	facilitated	facilitate	VERB
ajst-25616	140	8	by	by	ADP
ajst-25616	140	9	a	a	DET
ajst-25616	140	10	flexible	flexible	ADJ
ajst-25616	140	11	pocket	pocket	NOUN
ajst-25616	140	12	that	that	PRON
ajst-25616	140	13	is	be	AUX
ajst-25616	140	14	formed	form	VERB
ajst-25616	140	15	by	by	ADP
ajst-25616	140	16	the	the	DET
ajst-25616	140	17	convergence	convergence	NOUN
ajst-25616	140	18	of	of	ADP
ajst-25616	140	19	the	the	DET
ajst-25616	140	20	wedge	wedge	NOUN
ajst-25616	140	21	(	(	PUNCT
ajst-25616	140	22	we	we	NOUN
ajst-25616	140	23	d	d	PROPN
ajst-25616	140	24	)	)	PUNCT
ajst-25616	140	25	,	,	PUNCT
ajst-25616	140	26	the	the	DET
ajst-25616	140	27	rec1	rec1	NOUN
ajst-25616	140	28	subdomain	subdomain	NOUN
ajst-25616	140	29	,	,	PUNCT
ajst-25616	140	30	and	and	CCONJ
ajst-25616	140	31	the	the	DET
ajst-25616	140	32	paminteracting	paminteracting	NOUN
ajst-25616	140	33	(	(	PUNCT
ajst-25616	140	34	pi	pi	NOUN
ajst-25616	140	35	)	)	PUNCT
ajst-25616	140	36	domain	domain	NOUN
ajst-25616	140	37	.	.	PUNCT
ajst-25616	141	1	this	this	DET
ajst-25616	141	2	pocket	pocket	NOUN
ajst-25616	141	3	specifically	specifically	ADV
ajst-25616	141	4	binds	bind	VERB
ajst-25616	141	5	to	to	ADP
ajst-25616	141	6	a	a	DET
ajst-25616	141	7	protospacer	protospacer	NOUN
ajst-25616	141	8	adjacent	adjacent	ADJ
ajst-25616	141	9	motif	motif	NOUN
ajst-25616	141	10	(	(	PUNCT
ajst-25616	141	11	pam	pam	NOUN
ajst-25616	141	12	)	)	PUNCT
ajst-25616	141	13	on	on	ADP
ajst-25616	141	14	the	the	DET
ajst-25616	141	15	dna	dna	NOUN
ajst-25616	141	16	,	,	PUNCT
ajst-25616	141	17	which	which	PRON
ajst-25616	141	18	for	for	ADP
ajst-25616	141	19	cas12a	cas12a	NUM
ajst-25616	141	20	is	be	AUX
ajst-25616	141	21	typically	typically	ADV
ajst-25616	141	22	a	a	DET
ajst-25616	141	23	tttv	tttv	NOUN
ajst-25616	141	24	sequence	sequence	NOUN
ajst-25616	141	25	,	,	PUNCT
ajst-25616	141	26	where	where	SCONJ
ajst-25616	141	27	v	v	NOUN
ajst-25616	141	28	represents	represent	VERB
ajst-25616	141	29	a	a	DET
ajst-25616	141	30	,	,	PUNCT
ajst-25616	141	31	c	c	NOUN
ajst-25616	141	32	,	,	PUNCT
ajst-25616	141	33	or	or	CCONJ
ajst-25616	141	34	g[39	g[39	NOUN
ajst-25616	141	35	]	]	PUNCT
ajst-25616	141	36	,	,	PUNCT
ajst-25616	141	37	so	so	ADV
ajst-25616	141	38	its	its	PRON
ajst-25616	141	39	binding	binding	NOUN
ajst-25616	141	40	has	have	VERB
ajst-25616	141	41	high	high	ADJ
ajst-25616	141	42	specificity	specificity	NOUN
ajst-25616	141	43	and	and	CCONJ
ajst-25616	141	44	stability	stability	NOUN
ajst-25616	141	45	.	.	PUNCT
ajst-25616	142	1	in	in	ADP
ajst-25616	142	2	current	current	ADJ
ajst-25616	142	3	research	research	NOUN
ajst-25616	142	4	,	,	PUNCT
ajst-25616	142	5	a	a	DET
ajst-25616	142	6	well	well	ADV
ajst-25616	142	7	-	-	PUNCT
ajst-25616	142	8	established	establish	VERB
ajst-25616	142	9	method	method	NOUN
ajst-25616	142	10	is	be	AUX
ajst-25616	142	11	the	the	DET
ajst-25616	142	12	solidstate	solidstate	PROPN
ajst-25616	142	13	crispr	crispr	ADJ
ajst-25616	142	14	-	-	PUNCT
ajst-25616	142	15	cas12a	cas12a	NOUN
ajst-25616	142	16	-	-	PUNCT
ajst-25616	142	17	assisted	assist	VERB
ajst-25616	142	18	nanopores	nanopore	NOUN
ajst-25616	142	19	(	(	PUNCT
ajst-25616	142	20	scan	scan	PROPN
ajst-25616	142	21	)	)	PUNCT
ajst-25616	142	22	,	,	PUNCT
ajst-25616	142	23	which	which	PRON
ajst-25616	142	24	has	have	AUX
ajst-25616	142	25	been	be	AUX
ajst-25616	142	26	used	use	VERB
ajst-25616	142	27	for	for	ADP
ajst-25616	142	28	the	the	DET
ajst-25616	142	29	specific	specific	ADJ
ajst-25616	142	30	detection	detection	NOUN
ajst-25616	142	31	of	of	ADP
ajst-25616	142	32	hiv-1	hiv-1	PUNCT
ajst-25616	142	33	dna	dna	PROPN
ajst-25616	142	34	and	and	CCONJ
ajst-25616	142	35	has	have	AUX
ajst-25616	142	36	optimized	optimize	VERB
ajst-25616	142	37	the	the	DET
ajst-25616	142	38	buffer	buffer	NOUN
ajst-25616	142	39	conditions	condition	NOUN
ajst-25616	142	40	for	for	ADP
ajst-25616	142	41	nanopore	nanopore	ADJ
ajst-25616	142	42	sensing	sense	VERB
ajst-25616	142	43	[	[	X
ajst-25616	142	44	38,40	38,40	NUM
ajst-25616	142	45	]	]	PUNCT
ajst-25616	142	46	.	.	PUNCT
ajst-25616	143	1	however	however	ADV
ajst-25616	143	2	,	,	PUNCT
ajst-25616	143	3	in	in	ADP
ajst-25616	143	4	its	its	PRON
ajst-25616	143	5	early	early	ADJ
ajst-25616	143	6	stages	stage	NOUN
ajst-25616	143	7	,	,	PUNCT
ajst-25616	143	8	this	this	DET
ajst-25616	143	9	technology	technology	NOUN
ajst-25616	143	10	could	could	AUX
ajst-25616	143	11	not	not	PART
ajst-25616	143	12	detect	detect	VERB
ajst-25616	143	13	target	target	NOUN
ajst-25616	143	14	dna	dna	NOUN
ajst-25616	143	15	at	at	ADP
ajst-25616	143	16	concentrations	concentration	NOUN
ajst-25616	143	17	less	less	ADJ
ajst-25616	143	18	than	than	ADP
ajst-25616	143	19	10	10	NUM
ajst-25616	143	20	nm	nm	NOUN
ajst-25616	143	21	.	.	PUNCT
ajst-25616	144	1	therefore	therefore	ADV
ajst-25616	144	2	,	,	PUNCT
ajst-25616	144	3	a	a	DET
ajst-25616	144	4	reverse	reverse	ADJ
ajst-25616	144	5	transcription	transcription	NOUN
ajst-25616	144	6	amplification	amplification	NOUN
ajst-25616	144	7	coupled	couple	VERB
ajst-25616	144	8	with	with	ADP
ajst-25616	144	9	the	the	DET
ajst-25616	144	10	modified	modified	ADJ
ajst-25616	144	11	nanopore	nanopore	ADJ
ajst-25616	144	12	sensing	sense	VERB
ajst-25616	144	13	technique	technique	NOUN
ajst-25616	144	14	method	method	NOUN
ajst-25616	144	15	for	for	ADP
ajst-25616	144	16	scan	scan	ADJ
ajst-25616	144	17	devices	device	NOUN
ajst-25616	144	18	was	be	AUX
ajst-25616	144	19	developed	develop	VERB
ajst-25616	144	20	to	to	PART
ajst-25616	144	21	enhance	enhance	VERB
ajst-25616	144	22	sensitivity	sensitivity	NOUN
ajst-25616	144	23	,	,	PUNCT
ajst-25616	144	24	thereby	thereby	ADV
ajst-25616	144	25	allowing	allow	VERB
ajst-25616	144	26	the	the	DET
ajst-25616	144	27	examination	examination	NOUN
ajst-25616	144	28	of	of	ADP
ajst-25616	144	29	reporter	reporter	NOUN
ajst-25616	144	30	size	size	NOUN
ajst-25616	144	31	distributions	distribution	NOUN
ajst-25616	144	32	and	and	CCONJ
ajst-25616	144	33	their	their	PRON
ajst-25616	144	34	relative	relative	ADJ
ajst-25616	144	35	abundance	abundance	NOUN
ajst-25616	145	1	[	[	X
ajst-25616	145	2	40	40	NUM
ajst-25616	145	3	]	]	PUNCT
ajst-25616	145	4	.	.	PUNCT
ajst-25616	146	1	due	due	ADP
ajst-25616	146	2	to	to	ADP
ajst-25616	146	3	its	its	PRON
ajst-25616	146	4	highly	highly	ADV
ajst-25616	146	5	sensitive	sensitive	ADJ
ajst-25616	146	6	collateral	collateral	ADJ
ajst-25616	146	7	cleavage	cleavage	NOUN
ajst-25616	146	8	activity	activity	NOUN
ajst-25616	146	9	,	,	PUNCT
ajst-25616	146	10	the	the	DET
ajst-25616	146	11	intact	intact	ADJ
ajst-25616	146	12	circular	circular	ADJ
ajst-25616	146	13	single	single	ADJ
ajst-25616	146	14	-	-	PUNCT
ajst-25616	146	15	stranded	strand	VERB
ajst-25616	146	16	dna	dna	NOUN
ajst-25616	146	17	(	(	PUNCT
ajst-25616	146	18	ssdna	ssdna	NOUN
ajst-25616	146	19	)	)	PUNCT
ajst-25616	146	20	reporters	reporter	NOUN
ajst-25616	146	21	'	'	PART
ajst-25616	146	22	cleavage	cleavage	NOUN
ajst-25616	146	23	ratio	ratio	NOUN
ajst-25616	146	24	can	can	AUX
ajst-25616	146	25	be	be	AUX
ajst-25616	146	26	quantified	quantify	VERB
ajst-25616	146	27	using	use	VERB
ajst-25616	146	28	the	the	DET
ajst-25616	146	29	scan	scan	ADJ
ajst-25616	146	30	method	method	NOUN
ajst-25616	146	31	,	,	PUNCT
ajst-25616	146	32	which	which	PRON
ajst-25616	146	33	serves	serve	VERB
ajst-25616	146	34	as	as	ADP
ajst-25616	146	35	a	a	DET
ajst-25616	146	36	benchmark	benchmark	NOUN
ajst-25616	146	37	for	for	ADP
ajst-25616	146	38	distinguishing	distinguish	VERB
ajst-25616	146	39	between	between	ADP
ajst-25616	146	40	positive	positive	ADJ
ajst-25616	146	41	and	and	CCONJ
ajst-25616	146	42	negative	negative	ADJ
ajst-25616	146	43	test	test	NOUN
ajst-25616	146	44	outcomes	outcome	NOUN
ajst-25616	146	45	.	.	PUNCT
ajst-25616	147	1	the	the	DET
ajst-25616	147	2	cas12a	cas12a	ADJ
ajst-25616	147	3	protein	protein	NOUN
ajst-25616	147	4	's	's	PART
ajst-25616	147	5	collateral	collateral	ADJ
ajst-25616	147	6	cleavage	cleavage	NOUN
ajst-25616	147	7	activity	activity	NOUN
ajst-25616	147	8	,	,	PUNCT
ajst-25616	147	9	where	where	SCONJ
ajst-25616	147	10	it	it	PRON
ajst-25616	147	11	cuts	cut	VERB
ajst-25616	147	12	non	non	ADJ
ajst-25616	147	13	-	-	NOUN
ajst-25616	147	14	target	target	ADJ
ajst-25616	147	15	ssdna	ssdna	ADV
ajst-25616	147	16	after	after	ADP
ajst-25616	147	17	binding	bind	VERB
ajst-25616	147	18	to	to	PART
ajst-25616	147	19	dsdna	dsdna	VERB
ajst-25616	147	20	via	via	ADP
ajst-25616	147	21	rna	rna	NOUN
ajst-25616	147	22	guidance	guidance	NOUN
ajst-25616	147	23	,	,	PUNCT
ajst-25616	147	24	has	have	AUX
ajst-25616	147	25	been	be	AUX
ajst-25616	147	26	repurposed	repurpose	VERB
ajst-25616	147	27	for	for	ADP
ajst-25616	147	28	diagnostic	diagnostic	ADJ
ajst-25616	147	29	applications	application	NOUN
ajst-25616	147	30	.	.	PUNCT
ajst-25616	148	1	in	in	ADP
ajst-25616	148	2	the	the	DET
ajst-25616	148	3	scan	scan	PROPN
ajst-25616	148	4	method	method	NOUN
ajst-25616	148	5	,	,	PUNCT
ajst-25616	148	6	a	a	DET
ajst-25616	148	7	specific	specific	ADJ
ajst-25616	148	8	circular	circular	ADJ
ajst-25616	148	9	ssdna	ssdna	NOUN
ajst-25616	148	10	is	be	AUX
ajst-25616	148	11	used	use	VERB
ajst-25616	148	12	as	as	ADP
ajst-25616	148	13	a	a	DET
ajst-25616	148	14	reporter	reporter	NOUN
ajst-25616	148	15	and	and	CCONJ
ajst-25616	148	16	when	when	SCONJ
ajst-25616	148	17	the	the	DET
ajst-25616	148	18	target	target	NOUN
ajst-25616	148	19	dna	dna	NOUN
ajst-25616	148	20	,	,	PUNCT
ajst-25616	148	21	such	such	ADJ
ajst-25616	148	22	as	as	ADP
ajst-25616	148	23	hiv-1	hiv-1	NOUN
ajst-25616	148	24	,	,	PUNCT
ajst-25616	148	25	is	be	AUX
ajst-25616	148	26	present	present	ADJ
ajst-25616	148	27	,	,	PUNCT
ajst-25616	148	28	it	it	PRON
ajst-25616	148	29	activates	activate	VERB
ajst-25616	148	30	the	the	DET
ajst-25616	148	31	cas12a	cas12a	ADJ
ajst-25616	148	32	/	/	SYM
ajst-25616	148	33	crrna	crrna	NOUN
ajst-25616	148	34	complex	complex	NOUN
ajst-25616	148	35	,	,	PUNCT
ajst-25616	148	36	leading	lead	VERB
ajst-25616	148	37	to	to	ADP
ajst-25616	148	38	the	the	DET
ajst-25616	148	39	digestion	digestion	NOUN
ajst-25616	148	40	of	of	ADP
ajst-25616	148	41	the	the	DET
ajst-25616	148	42	reporter[40	reporter[40	NOUN
ajst-25616	148	43	]	]	PUNCT
ajst-25616	148	44	.	.	PUNCT
ajst-25616	149	1	the	the	DET
ajst-25616	149	2	degree	degree	NOUN
ajst-25616	149	3	of	of	ADP
ajst-25616	149	4	reporter	reporter	NOUN
ajst-25616	149	5	degradation	degradation	NOUN
ajst-25616	149	6	reflects	reflect	VERB
ajst-25616	149	7	the	the	DET
ajst-25616	149	8	target	target	NOUN
ajst-25616	149	9	dna	dna	NOUN
ajst-25616	149	10	's	's	PART
ajst-25616	149	11	concentration	concentration	NOUN
ajst-25616	149	12	.	.	PUNCT
ajst-25616	150	1	in	in	ADP
ajst-25616	150	2	the	the	DET
ajst-25616	150	3	absence	absence	NOUN
ajst-25616	150	4	of	of	ADP
ajst-25616	150	5	the	the	DET
ajst-25616	150	6	target	target	NOUN
ajst-25616	150	7	,	,	PUNCT
ajst-25616	150	8	the	the	DET
ajst-25616	150	9	reporter	reporter	NOUN
ajst-25616	150	10	remains	remain	VERB
ajst-25616	150	11	undigested	undigested	ADJ
ajst-25616	150	12	.	.	PUNCT
ajst-25616	151	1	the	the	DET
ajst-25616	151	2	scan	scan	ADJ
ajst-25616	151	3	technique	technique	NOUN
ajst-25616	151	4	uses	use	VERB
ajst-25616	151	5	nanopores	nanopore	NOUN
ajst-25616	151	6	for	for	ADP
ajst-25616	151	7	electronic	electronic	ADJ
ajst-25616	151	8	quantification	quantification	NOUN
ajst-25616	151	9	of	of	ADP
ajst-25616	151	10	the	the	DET
ajst-25616	151	11	reporter	reporter	NOUN
ajst-25616	151	12	,	,	PUNCT
ajst-25616	151	13	allowing	allow	VERB
ajst-25616	151	14	for	for	ADP
ajst-25616	151	15	sensitive	sensitive	ADJ
ajst-25616	151	16	detection	detection	NOUN
ajst-25616	151	17	of	of	ADP
ajst-25616	151	18	specific	specific	ADJ
ajst-25616	151	19	dna	dna	NOUN
ajst-25616	151	20	sequences[40	sequences[40	NOUN
ajst-25616	151	21	]	]	PUNCT
ajst-25616	151	22	.	.	PUNCT
ajst-25616	152	1	the	the	DET
ajst-25616	152	2	specific	specific	ADJ
ajst-25616	152	3	binding	binding	NOUN
ajst-25616	152	4	of	of	ADP
ajst-25616	152	5	the	the	DET
ajst-25616	152	6	cas12a	cas12a	ADJ
ajst-25616	152	7	protein	protein	NOUN
ajst-25616	152	8	quantifies	quantify	VERB
ajst-25616	152	9	the	the	DET
ajst-25616	152	10	nanopore	nanopore	ADV
ajst-25616	152	11	sequencing	sequence	VERB
ajst-25616	152	12	technology	technology	NOUN
ajst-25616	152	13	,	,	PUNCT
ajst-25616	152	14	thereby	thereby	ADV
ajst-25616	152	15	elevating	elevate	VERB
ajst-25616	152	16	this	this	DET
ajst-25616	152	17	technique	technique	NOUN
ajst-25616	152	18	to	to	ADP
ajst-25616	152	19	a	a	DET
ajst-25616	152	20	higher	high	ADJ
ajst-25616	152	21	level	level	NOUN
ajst-25616	152	22	.	.	PUNCT
ajst-25616	153	1	4.3.3	4.3.3	X
ajst-25616	153	2	.	.	PUNCT
ajst-25616	153	3	cas13a	cas13a	NOUN
ajst-25616	153	4	/	/	SYM
ajst-25616	153	5	b	b	NOUN
ajst-25616	153	6	-	-	PUNCT
ajst-25616	153	7	mediated	mediate	VERB
ajst-25616	153	8	nanopore	nanopore	ADV
ajst-25616	153	9	sequencing	sequence	VERB
ajst-25616	153	10	similarly	similarly	ADV
ajst-25616	153	11	,	,	PUNCT
ajst-25616	153	12	for	for	ADP
ajst-25616	153	13	cas13a	cas13a	X
ajst-25616	153	14	(	(	PUNCT
ajst-25616	153	15	formerly	formerly	ADV
ajst-25616	153	16	known	know	VERB
ajst-25616	153	17	as	as	ADP
ajst-25616	153	18	c2c2	c2c2	NOUN
ajst-25616	153	19	)	)	PUNCT
ajst-25616	153	20	or	or	CCONJ
ajst-25616	153	21	cas13b	cas13b	NOUN
ajst-25616	153	22	proteins	protein	NOUN
ajst-25616	153	23	,	,	PUNCT
ajst-25616	153	24	they	they	PRON
ajst-25616	153	25	exhibit	exhibit	VERB
ajst-25616	153	26	a	a	DET
ajst-25616	153	27	"	"	PUNCT
ajst-25616	153	28	collateral	collateral	ADJ
ajst-25616	153	29	effect	effect	NOUN
ajst-25616	153	30	"	"	PUNCT
ajst-25616	153	31	of	of	ADP
ajst-25616	153	32	mixed	mix	VERB
ajst-25616	153	33	-	-	PUNCT
ajst-25616	153	34	up	up	ADP
ajst-25616	153	35	ribonuclease	ribonuclease	NOUN
ajst-25616	153	36	activity	activity	NOUN
ajst-25616	153	37	upon	upon	SCONJ
ajst-25616	153	38	the	the	DET
ajst-25616	153	39	recognition	recognition	NOUN
ajst-25616	153	40	of	of	ADP
ajst-25616	153	41	targets	target	NOUN
ajst-25616	153	42	.	.	PUNCT
ajst-25616	154	1	scientists	scientist	NOUN
ajst-25616	154	2	have	have	AUX
ajst-25616	154	3	integrated	integrate	VERB
ajst-25616	154	4	this	this	DET
ajst-25616	154	5	phenomenon	phenomenon	NOUN
ajst-25616	154	6	with	with	ADP
ajst-25616	154	7	isothermal	isothermal	ADJ
ajst-25616	154	8	amplification	amplification	NOUN
ajst-25616	154	9	techniques	technique	NOUN
ajst-25616	154	10	to	to	PART
ajst-25616	154	11	devise	devise	VERB
ajst-25616	154	12	a	a	DET
ajst-25616	154	13	system	system	NOUN
ajst-25616	154	14	for	for	ADP
ajst-25616	154	15	detecting	detect	VERB
ajst-25616	154	16	nucleic	nucleic	ADJ
ajst-25616	154	17	acids	acid	NOUN
ajst-25616	154	18	that	that	PRON
ajst-25616	154	19	leverages	leverage	VERB
ajst-25616	154	20	these	these	DET
ajst-25616	154	21	proteins	protein	NOUN
ajst-25616	154	22	,	,	PUNCT
ajst-25616	154	23	termed	term	VERB
ajst-25616	154	24	sherlock	sherlock	PROPN
ajst-25616	154	25	technology	technology	PROPN
ajst-25616	154	26	,	,	PUNCT
ajst-25616	154	27	which	which	PRON
ajst-25616	154	28	stands	stand	VERB
ajst-25616	154	29	for	for	ADP
ajst-25616	154	30	specific	specific	ADJ
ajst-25616	154	31	highsensitivity	highsensitivity	NOUN
ajst-25616	154	32	enzymatic	enzymatic	ADJ
ajst-25616	154	33	reporter	reporter	NOUN
ajst-25616	154	34	unlocking	unlocking	NOUN
ajst-25616	154	35	.	.	PUNCT
ajst-25616	155	1	it	it	PRON
ajst-25616	155	2	has	have	AUX
ajst-25616	155	3	been	be	AUX
ajst-25616	155	4	utilized	utilize	VERB
ajst-25616	155	5	for	for	ADP
ajst-25616	155	6	various	various	ADJ
ajst-25616	155	7	sensitive	sensitive	ADJ
ajst-25616	155	8	detections	detection	NOUN
ajst-25616	155	9	,	,	PUNCT
ajst-25616	155	10	including	include	VERB
ajst-25616	155	11	identifying	identify	VERB
ajst-25616	155	12	specific	specific	ADJ
ajst-25616	155	13	strains	strain	NOUN
ajst-25616	155	14	of	of	ADP
ajst-25616	155	15	zika	zika	X
ajst-25616	155	16	and	and	CCONJ
ajst-25616	155	17	dengue	dengue	NOUN
ajst-25616	155	18	viruses	virus	NOUN
ajst-25616	155	19	,	,	PUNCT
ajst-25616	155	20	differentiating	differentiate	VERB
ajst-25616	155	21	harmful	harmful	ADJ
ajst-25616	155	22	bacteria	bacteria	NOUN
ajst-25616	155	23	,	,	PUNCT
ajst-25616	155	24	genotyping	genotype	VERB
ajst-25616	155	25	human	human	ADJ
ajst-25616	155	26	dna	dna	PROPN
ajst-25616	155	27	,	,	PUNCT
ajst-25616	155	28	recognizing	recognize	VERB
ajst-25616	155	29	mutations	mutation	NOUN
ajst-25616	155	30	in	in	ADP
ajst-25616	155	31	circulating	circulate	VERB
ajst-25616	155	32	tumor	tumor	NOUN
ajst-25616	155	33	dna	dna	NOUN
ajst-25616	155	34	[	[	X
ajst-25616	155	35	41	41	NUM
ajst-25616	155	36	]	]	PUNCT
ajst-25616	155	37	.	.	PUNCT
ajst-25616	156	1	moreover	moreover	ADV
ajst-25616	156	2	,	,	PUNCT
ajst-25616	156	3	sherlock	sherlock	NOUN
ajst-25616	156	4	reagents	reagent	NOUN
ajst-25616	156	5	could	could	AUX
ajst-25616	156	6	be	be	AUX
ajst-25616	156	7	freeze	freeze	NOUN
ajst-25616	156	8	-	-	PUNCT
ajst-25616	156	9	dried	dry	VERB
ajst-25616	156	10	to	to	PART
ajst-25616	156	11	eliminate	eliminate	VERB
ajst-25616	156	12	the	the	DET
ajst-25616	156	13	need	need	NOUN
ajst-25616	156	14	for	for	ADP
ajst-25616	156	15	cold	cold	ADJ
ajst-25616	156	16	storage	storage	NOUN
ajst-25616	156	17	and	and	CCONJ
ajst-25616	156	18	can	can	AUX
ajst-25616	156	19	be	be	AUX
ajst-25616	156	20	easily	easily	ADV
ajst-25616	156	21	restored	restore	VERB
ajst-25616	156	22	when	when	SCONJ
ajst-25616	156	23	needed	need	VERB
ajst-25616	156	24	,	,	PUNCT
ajst-25616	156	25	making	make	VERB
ajst-25616	156	26	them	they	PRON
ajst-25616	156	27	suitable	suitable	ADJ
ajst-25616	156	28	for	for	ADP
ajst-25616	156	29	use	use	NOUN
ajst-25616	156	30	in	in	ADP
ajst-25616	156	31	paper	paper	NOUN
ajst-25616	156	32	-	-	PUNCT
ajst-25616	156	33	based	base	VERB
ajst-25616	156	34	formats	format	NOUN
ajst-25616	156	35	that	that	PRON
ajst-25616	156	36	are	be	AUX
ajst-25616	156	37	ideal	ideal	ADJ
ajst-25616	156	38	for	for	ADP
ajst-25616	156	39	on	on	ADP
ajst-25616	156	40	-	-	PUNCT
ajst-25616	156	41	site	site	NOUN
ajst-25616	156	42	testing	testing	NOUN
ajst-25616	156	43	and	and	CCONJ
ajst-25616	156	44	applications	application	NOUN
ajst-25616	156	45	in	in	ADP
ajst-25616	156	46	resource	resource	NOUN
ajst-25616	156	47	-	-	PUNCT
ajst-25616	156	48	limited	limit	VERB
ajst-25616	156	49	settings	setting	NOUN
ajst-25616	157	1	[	[	X
ajst-25616	157	2	41	41	NUM
ajst-25616	157	3	]	]	PUNCT
ajst-25616	157	4	.	.	PUNCT
ajst-25616	158	1	the	the	DET
ajst-25616	158	2	collateral	collateral	ADJ
ajst-25616	158	3	cleavage	cleavage	NOUN
ajst-25616	158	4	significantly	significantly	ADV
ajst-25616	158	5	enhances	enhance	VERB
ajst-25616	158	6	the	the	DET
ajst-25616	158	7	sensitivity	sensitivity	NOUN
ajst-25616	158	8	of	of	ADP
ajst-25616	158	9	rna	rna	NOUN
ajst-25616	158	10	detection	detection	NOUN
ajst-25616	158	11	[	[	X
ajst-25616	158	12	42	42	NUM
ajst-25616	158	13	]	]	PUNCT
ajst-25616	158	14	.	.	PUNCT
ajst-25616	159	1	regrettably	regrettably	ADV
ajst-25616	159	2	,	,	PUNCT
ajst-25616	159	3	the	the	DET
ajst-25616	159	4	author	author	NOUN
ajst-25616	159	5	is	be	AUX
ajst-25616	159	6	not	not	PART
ajst-25616	159	7	aware	aware	ADJ
ajst-25616	159	8	of	of	ADP
ajst-25616	159	9	any	any	DET
ajst-25616	159	10	research	research	NOUN
ajst-25616	159	11	cases	case	NOUN
ajst-25616	159	12	combining	combine	VERB
ajst-25616	159	13	such	such	ADJ
ajst-25616	159	14	cas13	cas13	ADJ
ajst-25616	159	15	proteins	protein	NOUN
ajst-25616	159	16	with	with	ADP
ajst-25616	159	17	third	third	ADJ
ajst-25616	159	18	-	-	PUNCT
ajst-25616	159	19	generation	generation	NOUN
ajst-25616	159	20	sequencing	sequencing	NOUN
ajst-25616	159	21	,	,	PUNCT
ajst-25616	159	22	hence	hence	ADV
ajst-25616	159	23	will	will	AUX
ajst-25616	159	24	not	not	PART
ajst-25616	159	25	elaborate	elaborate	VERB
ajst-25616	159	26	further	far	ADV
ajst-25616	159	27	on	on	ADP
ajst-25616	159	28	this	this	DET
ajst-25616	159	29	topic	topic	NOUN
ajst-25616	159	30	.	.	PUNCT
ajst-25616	160	1	188	188	NUM
ajst-25616	160	2	5	5	NUM
ajst-25616	160	3	.	.	PUNCT
ajst-25616	160	4	conclusion	conclusion	NOUN
ajst-25616	160	5	and	and	CCONJ
ajst-25616	160	6	prospect	prospect	NOUN
ajst-25616	160	7	in	in	ADP
ajst-25616	160	8	this	this	DET
ajst-25616	160	9	article	article	NOUN
ajst-25616	160	10	,	,	PUNCT
ajst-25616	160	11	we	we	PRON
ajst-25616	160	12	have	have	AUX
ajst-25616	160	13	discussed	discuss	VERB
ajst-25616	160	14	research	research	NOUN
ajst-25616	160	15	related	relate	VERB
ajst-25616	160	16	to	to	ADP
ajst-25616	160	17	the	the	DET
ajst-25616	160	18	crispr	crispr	ADJ
ajst-25616	160	19	/	/	SYM
ajst-25616	160	20	cas	cas	NOUN
ajst-25616	160	21	system	system	NOUN
ajst-25616	160	22	,	,	PUNCT
ajst-25616	160	23	providing	provide	VERB
ajst-25616	160	24	a	a	DET
ajst-25616	160	25	preliminary	preliminary	ADJ
ajst-25616	160	26	overview	overview	NOUN
ajst-25616	160	27	of	of	ADP
ajst-25616	160	28	its	its	PRON
ajst-25616	160	29	principles	principle	NOUN
ajst-25616	160	30	.	.	PUNCT
ajst-25616	161	1	we	we	PRON
ajst-25616	161	2	introduced	introduce	VERB
ajst-25616	161	3	third	third	ADJ
ajst-25616	161	4	-	-	PUNCT
ajst-25616	161	5	generation	generation	NOUN
ajst-25616	161	6	sequencing	sequence	VERB
ajst-25616	161	7	technology	technology	NOUN
ajst-25616	161	8	and	and	CCONJ
ajst-25616	161	9	explored	explore	VERB
ajst-25616	161	10	the	the	DET
ajst-25616	161	11	enrichment	enrichment	NOUN
ajst-25616	161	12	and	and	CCONJ
ajst-25616	161	13	improvements	improvement	NOUN
ajst-25616	161	14	of	of	ADP
ajst-25616	161	15	crispr	crispr	ADJ
ajst-25616	161	16	/	/	SYM
ajst-25616	161	17	cas	cas	NOUN
ajst-25616	161	18	system	system	NOUN
ajst-25616	161	19	-	-	PUNCT
ajst-25616	161	20	mediated	mediate	VERB
ajst-25616	161	21	third	third	ADJ
ajst-25616	161	22	-	-	PUNCT
ajst-25616	161	23	generation	generation	NOUN
ajst-25616	161	24	sequencing	sequence	VERB
ajst-25616	161	25	technology	technology	NOUN
ajst-25616	161	26	.	.	PUNCT
ajst-25616	162	1	we	we	PRON
ajst-25616	162	2	also	also	ADV
ajst-25616	162	3	briefly	briefly	ADV
ajst-25616	162	4	introduced	introduce	VERB
ajst-25616	162	5	methods	method	NOUN
ajst-25616	162	6	for	for	ADP
ajst-25616	162	7	data	datum	NOUN
ajst-25616	162	8	analysis	analysis	NOUN
ajst-25616	162	9	and	and	CCONJ
ajst-25616	162	10	processing	processing	NOUN
ajst-25616	162	11	,	,	PUNCT
ajst-25616	162	12	revealing	reveal	VERB
ajst-25616	162	13	the	the	DET
ajst-25616	162	14	immense	immense	ADJ
ajst-25616	162	15	potential	potential	NOUN
ajst-25616	162	16	of	of	ADP
ajst-25616	162	17	this	this	DET
ajst-25616	162	18	cutting	cut	VERB
ajst-25616	162	19	-	-	PUNCT
ajst-25616	162	20	edge	edge	NOUN
ajst-25616	162	21	technology	technology	NOUN
ajst-25616	162	22	in	in	ADP
ajst-25616	162	23	genomic	genomic	ADJ
ajst-25616	162	24	research	research	NOUN
ajst-25616	162	25	.	.	PUNCT
ajst-25616	163	1	it	it	PRON
ajst-25616	163	2	can	can	AUX
ajst-25616	163	3	not	not	PART
ajst-25616	163	4	only	only	ADV
ajst-25616	163	5	provide	provide	VERB
ajst-25616	163	6	higher	high	ADJ
ajst-25616	163	7	target	target	NOUN
ajst-25616	163	8	accuracy	accuracy	NOUN
ajst-25616	163	9	but	but	CCONJ
ajst-25616	163	10	also	also	ADV
ajst-25616	163	11	reduce	reduce	VERB
ajst-25616	163	12	interference	interference	NOUN
ajst-25616	163	13	in	in	ADP
ajst-25616	163	14	the	the	DET
ajst-25616	163	15	target	target	NOUN
ajst-25616	163	16	sequence	sequence	NOUN
ajst-25616	163	17	caused	cause	VERB
ajst-25616	163	18	by	by	ADP
ajst-25616	163	19	factors	factor	NOUN
ajst-25616	163	20	such	such	ADJ
ajst-25616	163	21	as	as	ADP
ajst-25616	163	22	high	high	ADJ
ajst-25616	163	23	cg	cg	NOUN
ajst-25616	163	24	content	content	NOUN
ajst-25616	163	25	or	or	CCONJ
ajst-25616	163	26	overly	overly	ADV
ajst-25616	163	27	complex	complex	ADJ
ajst-25616	163	28	structural	structural	ADJ
ajst-25616	163	29	variations	variation	NOUN
ajst-25616	163	30	through	through	ADP
ajst-25616	163	31	an	an	DET
ajst-25616	163	32	amplification	amplification	NOUN
ajst-25616	163	33	-	-	PUNCT
ajst-25616	163	34	free	free	ADJ
ajst-25616	163	35	approach	approach	NOUN
ajst-25616	163	36	,	,	PUNCT
ajst-25616	163	37	showing	show	VERB
ajst-25616	163	38	a	a	DET
ajst-25616	163	39	promising	promising	ADJ
ajst-25616	163	40	prospect	prospect	NOUN
ajst-25616	163	41	for	for	ADP
ajst-25616	163	42	development	development	NOUN
ajst-25616	163	43	and	and	CCONJ
ajst-25616	163	44	application	application	NOUN
ajst-25616	163	45	.	.	PUNCT
ajst-25616	164	1	despite	despite	SCONJ
ajst-25616	164	2	the	the	DET
ajst-25616	164	3	application	application	NOUN
ajst-25616	164	4	of	of	ADP
ajst-25616	164	5	the	the	DET
ajst-25616	164	6	crispr	crispr	ADJ
ajst-25616	164	7	/	/	SYM
ajst-25616	164	8	cas	cas	NOUN
ajst-25616	164	9	system	system	NOUN
ajst-25616	164	10	and	and	CCONJ
ajst-25616	164	11	its	its	PRON
ajst-25616	164	12	favor	favor	NOUN
ajst-25616	164	13	for	for	ADP
ajst-25616	164	14	its	its	PRON
ajst-25616	164	15	efficiency	efficiency	NOUN
ajst-25616	164	16	and	and	CCONJ
ajst-25616	164	17	accuracy	accuracy	NOUN
ajst-25616	164	18	,	,	PUNCT
ajst-25616	164	19	challenges	challenge	NOUN
ajst-25616	164	20	and	and	CCONJ
ajst-25616	164	21	limitations	limitation	NOUN
ajst-25616	164	22	persist	persist	VERB
ajst-25616	164	23	.	.	PUNCT
ajst-25616	165	1	off	off	ADP
ajst-25616	165	2	-	-	PUNCT
ajst-25616	165	3	target	target	NOUN
ajst-25616	165	4	effects	effect	NOUN
ajst-25616	165	5	and	and	CCONJ
ajst-25616	165	6	the	the	DET
ajst-25616	165	7	difficulty	difficulty	NOUN
ajst-25616	165	8	of	of	ADP
ajst-25616	165	9	achieving	achieve	VERB
ajst-25616	165	10	more	more	ADJ
ajst-25616	165	11	than	than	ADP
ajst-25616	165	12	99	99	NUM
ajst-25616	165	13	%	%	NOUN
ajst-25616	165	14	accuracy	accuracy	NOUN
ajst-25616	165	15	have	have	AUX
ajst-25616	165	16	always	always	ADV
ajst-25616	165	17	been	be	AUX
ajst-25616	165	18	core	core	ADJ
ajst-25616	165	19	issues	issue	NOUN
ajst-25616	165	20	in	in	ADP
ajst-25616	165	21	the	the	DET
ajst-25616	165	22	field	field	NOUN
ajst-25616	165	23	of	of	ADP
ajst-25616	165	24	gene	gene	NOUN
ajst-25616	165	25	editing	editing	NOUN
ajst-25616	165	26	,	,	PUNCT
ajst-25616	165	27	potentially	potentially	ADV
ajst-25616	165	28	leading	lead	VERB
ajst-25616	165	29	to	to	ADP
ajst-25616	165	30	unexpected	unexpected	ADJ
ajst-25616	165	31	mutations	mutation	NOUN
ajst-25616	165	32	at	at	ADP
ajst-25616	165	33	non	non	ADJ
ajst-25616	165	34	-	-	ADJ
ajst-25616	165	35	target	target	ADJ
ajst-25616	165	36	sites	site	NOUN
ajst-25616	165	37	,	,	PUNCT
ajst-25616	165	38	thereby	thereby	ADV
ajst-25616	165	39	affecting	affect	VERB
ajst-25616	165	40	gene	gene	NOUN
ajst-25616	165	41	function	function	NOUN
ajst-25616	165	42	and	and	CCONJ
ajst-25616	165	43	cell	cell	NOUN
ajst-25616	165	44	stability	stability	NOUN
ajst-25616	165	45	,	,	PUNCT
ajst-25616	165	46	and	and	CCONJ
ajst-25616	165	47	ultimately	ultimately	ADV
ajst-25616	165	48	causing	cause	VERB
ajst-25616	165	49	sequencing	sequence	VERB
ajst-25616	165	50	results	result	NOUN
ajst-25616	165	51	and	and	CCONJ
ajst-25616	165	52	analysis	analysis	NOUN
ajst-25616	165	53	errors	error	NOUN
ajst-25616	165	54	.	.	PUNCT
ajst-25616	166	1	in	in	ADP
ajst-25616	166	2	addition	addition	NOUN
ajst-25616	166	3	,	,	PUNCT
ajst-25616	166	4	improving	improve	VERB
ajst-25616	166	5	editing	edit	VERB
ajst-25616	166	6	efficiency	efficiency	NOUN
ajst-25616	166	7	is	be	AUX
ajst-25616	166	8	also	also	ADV
ajst-25616	166	9	key	key	ADJ
ajst-25616	166	10	to	to	ADP
ajst-25616	166	11	further	further	ADJ
ajst-25616	166	12	development	development	NOUN
ajst-25616	166	13	,	,	PUNCT
ajst-25616	166	14	especially	especially	ADV
ajst-25616	166	15	when	when	SCONJ
ajst-25616	166	16	dealing	deal	VERB
ajst-25616	166	17	with	with	ADP
ajst-25616	166	18	complex	complex	ADJ
ajst-25616	166	19	or	or	CCONJ
ajst-25616	166	20	hard	hard	ADV
ajst-25616	166	21	-	-	PUNCT
ajst-25616	166	22	to	to	ADP
ajst-25616	166	23	-	-	PUNCT
ajst-25616	166	24	edit	edit	VERB
ajst-25616	166	25	genomic	genomic	ADJ
ajst-25616	166	26	regions	region	NOUN
ajst-25616	166	27	.	.	PUNCT
ajst-25616	167	1	faced	face	VERB
ajst-25616	167	2	with	with	ADP
ajst-25616	167	3	these	these	DET
ajst-25616	167	4	challenges	challenge	NOUN
ajst-25616	167	5	,	,	PUNCT
ajst-25616	167	6	for	for	ADP
ajst-25616	167	7	the	the	DET
ajst-25616	167	8	crispr	crispr	ADJ
ajst-25616	167	9	/	/	SYM
ajst-25616	167	10	cas	cas	NOUN
ajst-25616	167	11	system	system	NOUN
ajst-25616	167	12	,	,	PUNCT
ajst-25616	167	13	one	one	PRON
ajst-25616	167	14	can	can	AUX
ajst-25616	167	15	start	start	VERB
ajst-25616	167	16	by	by	ADP
ajst-25616	167	17	optimizing	optimize	VERB
ajst-25616	167	18	grna	grna	NOUN
ajst-25616	167	19	design	design	NOUN
ajst-25616	167	20	,	,	PUNCT
ajst-25616	167	21	selecting	select	VERB
ajst-25616	167	22	cas	cas	NOUN
ajst-25616	167	23	proteins	protein	NOUN
ajst-25616	167	24	,	,	PUNCT
ajst-25616	167	25	and	and	CCONJ
ajst-25616	167	26	enhancing	enhance	VERB
ajst-25616	167	27	the	the	DET
ajst-25616	167	28	specificity	specificity	NOUN
ajst-25616	167	29	of	of	ADP
ajst-25616	167	30	the	the	DET
ajst-25616	167	31	dsbs	dsbs	ADJ
ajst-25616	167	32	repair	repair	NOUN
ajst-25616	167	33	pathway	pathway	NOUN
ajst-25616	167	34	.	.	PUNCT
ajst-25616	168	1	through	through	ADP
ajst-25616	168	2	such	such	ADJ
ajst-25616	168	3	improvements	improvement	NOUN
ajst-25616	168	4	,	,	PUNCT
ajst-25616	168	5	the	the	DET
ajst-25616	168	6	system	system	NOUN
ajst-25616	168	7	can	can	AUX
ajst-25616	168	8	play	play	VERB
ajst-25616	168	9	a	a	DET
ajst-25616	168	10	central	central	ADJ
ajst-25616	168	11	role	role	NOUN
ajst-25616	168	12	in	in	ADP
ajst-25616	168	13	gene	gene	NOUN
ajst-25616	168	14	function	function	NOUN
ajst-25616	168	15	research	research	NOUN
ajst-25616	168	16	,	,	PUNCT
ajst-25616	168	17	disease	disease	NOUN
ajst-25616	168	18	model	model	NOUN
ajst-25616	168	19	construction	construction	NOUN
ajst-25616	168	20	,	,	PUNCT
ajst-25616	168	21	and	and	CCONJ
ajst-25616	168	22	precise	precise	ADJ
ajst-25616	168	23	gene	gene	NOUN
ajst-25616	168	24	editing	editing	NOUN
ajst-25616	168	25	and	and	CCONJ
ajst-25616	168	26	therapeutics	therapeutic	NOUN
ajst-25616	168	27	.	.	PUNCT
ajst-25616	169	1	for	for	ADP
ajst-25616	169	2	sequencing	sequence	VERB
ajst-25616	169	3	technologies	technology	NOUN
ajst-25616	169	4	,	,	PUNCT
ajst-25616	169	5	there	there	PRON
ajst-25616	169	6	are	be	VERB
ajst-25616	169	7	multiple	multiple	ADJ
ajst-25616	169	8	directions	direction	NOUN
ajst-25616	169	9	for	for	ADP
ajst-25616	169	10	improvement	improvement	NOUN
ajst-25616	169	11	.	.	PUNCT
ajst-25616	170	1	firstly	firstly	ADV
ajst-25616	170	2	,	,	PUNCT
ajst-25616	170	3	technological	technological	ADJ
ajst-25616	170	4	innovation	innovation	NOUN
ajst-25616	170	5	can	can	AUX
ajst-25616	170	6	further	far	ADV
ajst-25616	170	7	enhance	enhance	VERB
ajst-25616	170	8	the	the	DET
ajst-25616	170	9	throughput	throughput	NOUN
ajst-25616	170	10	and	and	CCONJ
ajst-25616	170	11	data	datum	NOUN
ajst-25616	170	12	output	output	NOUN
ajst-25616	170	13	of	of	ADP
ajst-25616	170	14	sequencing	sequence	VERB
ajst-25616	170	15	,	,	PUNCT
ajst-25616	170	16	such	such	ADJ
ajst-25616	170	17	as	as	ADP
ajst-25616	170	18	increasing	increase	VERB
ajst-25616	170	19	the	the	DET
ajst-25616	170	20	number	number	NOUN
ajst-25616	170	21	of	of	ADP
ajst-25616	170	22	zmws	zmws	NOUN
ajst-25616	170	23	(	(	PUNCT
ajst-25616	170	24	zero	zero	NUM
ajst-25616	170	25	-	-	PUNCT
ajst-25616	170	26	mode	mode	NOUN
ajst-25616	170	27	waveguides	waveguide	NOUN
ajst-25616	170	28	)	)	PUNCT
ajst-25616	170	29	in	in	ADP
ajst-25616	170	30	a	a	DET
ajst-25616	170	31	single	single	ADJ
ajst-25616	170	32	sequencing	sequencing	NOUN
ajst-25616	170	33	reaction	reaction	NOUN
ajst-25616	170	34	or	or	CCONJ
ajst-25616	170	35	optimizing	optimize	VERB
ajst-25616	170	36	sequencing	sequence	VERB
ajst-25616	170	37	conditions	condition	NOUN
ajst-25616	170	38	,	,	PUNCT
ajst-25616	170	39	thereby	thereby	ADV
ajst-25616	170	40	obtaining	obtain	VERB
ajst-25616	170	41	more	more	ADJ
ajst-25616	170	42	high	high	ADJ
ajst-25616	170	43	-	-	PUNCT
ajst-25616	170	44	quality	quality	NOUN
ajst-25616	170	45	data	datum	NOUN
ajst-25616	170	46	in	in	ADP
ajst-25616	170	47	one	one	NUM
ajst-25616	170	48	sequencing	sequence	VERB
ajst-25616	170	49	run	run	NOUN
ajst-25616	170	50	.	.	PUNCT
ajst-25616	171	1	secondly	secondly	ADV
ajst-25616	171	2	,	,	PUNCT
ajst-25616	171	3	enhancing	enhance	VERB
ajst-25616	171	4	the	the	DET
ajst-25616	171	5	read	read	NOUN
ajst-25616	171	6	length	length	NOUN
ajst-25616	171	7	and	and	CCONJ
ajst-25616	171	8	quality	quality	NOUN
ajst-25616	171	9	of	of	ADP
ajst-25616	171	10	sequencing	sequencing	NOUN
ajst-25616	171	11	can	can	AUX
ajst-25616	171	12	increase	increase	VERB
ajst-25616	171	13	the	the	DET
ajst-25616	171	14	scope	scope	NOUN
ajst-25616	171	15	and	and	CCONJ
ajst-25616	171	16	precision	precision	NOUN
ajst-25616	171	17	of	of	ADP
ajst-25616	171	18	sequencing	sequence	VERB
ajst-25616	171	19	.	.	PUNCT
ajst-25616	172	1	of	of	ADP
ajst-25616	172	2	course	course	NOUN
ajst-25616	172	3	,	,	PUNCT
ajst-25616	172	4	with	with	ADP
ajst-25616	172	5	these	these	DET
ajst-25616	172	6	advancements	advancement	NOUN
ajst-25616	172	7	,	,	PUNCT
ajst-25616	172	8	improving	improve	VERB
ajst-25616	172	9	data	datum	NOUN
ajst-25616	172	10	processing	processing	NOUN
ajst-25616	172	11	and	and	CCONJ
ajst-25616	172	12	analysis	analysis	NOUN
ajst-25616	172	13	tools	tool	NOUN
ajst-25616	172	14	also	also	ADV
ajst-25616	172	15	becomes	become	VERB
ajst-25616	172	16	essential	essential	ADJ
ajst-25616	172	17	to	to	PART
ajst-25616	172	18	handle	handle	VERB
ajst-25616	172	19	more	more	ADV
ajst-25616	172	20	complex	complex	ADJ
ajst-25616	172	21	and	and	CCONJ
ajst-25616	172	22	vast	vast	ADJ
ajst-25616	172	23	genomes	genome	NOUN
ajst-25616	172	24	.	.	PUNCT
ajst-25616	173	1	at	at	ADP
ajst-25616	173	2	the	the	DET
ajst-25616	173	3	same	same	ADJ
ajst-25616	173	4	time	time	NOUN
ajst-25616	173	5	,	,	PUNCT
ajst-25616	173	6	the	the	DET
ajst-25616	173	7	development	development	NOUN
ajst-25616	173	8	of	of	ADP
ajst-25616	173	9	third	third	ADJ
ajst-25616	173	10	-	-	PUNCT
ajst-25616	173	11	generation	generation	NOUN
ajst-25616	173	12	sequencing	sequence	VERB
ajst-25616	173	13	technologies	technology	NOUN
ajst-25616	173	14	,	,	PUNCT
ajst-25616	173	15	especially	especially	ADV
ajst-25616	173	16	those	those	PRON
ajst-25616	173	17	mediated	mediate	VERB
ajst-25616	173	18	by	by	ADP
ajst-25616	173	19	the	the	DET
ajst-25616	173	20	crispr	crispr	PROPN
ajst-25616	173	21	/	/	SYM
ajst-25616	173	22	cas	cas	PROPN
ajst-25616	173	23	family	family	NOUN
ajst-25616	173	24	such	such	ADJ
ajst-25616	173	25	as	as	ADP
ajst-25616	173	26	smrt	smrt	NOUN
ajst-25616	173	27	(	(	PUNCT
ajst-25616	173	28	single	single	ADJ
ajst-25616	173	29	molecule	molecule	NOUN
ajst-25616	173	30	realtime	realtime	NOUN
ajst-25616	173	31	)	)	PUNCT
ajst-25616	173	32	and	and	CCONJ
ajst-25616	173	33	the	the	DET
ajst-25616	173	34	nanopore	nanopore	ADJ
ajst-25616	173	35	sequencing	sequencing	NOUN
ajst-25616	173	36	,	,	PUNCT
ajst-25616	173	37	provides	provide	VERB
ajst-25616	173	38	a	a	DET
ajst-25616	173	39	fresh	fresh	ADJ
ajst-25616	173	40	perspective	perspective	NOUN
ajst-25616	173	41	for	for	ADP
ajst-25616	173	42	genomic	genomic	ADJ
ajst-25616	173	43	research	research	NOUN
ajst-25616	173	44	through	through	ADP
ajst-25616	173	45	different	different	ADJ
ajst-25616	173	46	cas	cas	NOUN
ajst-25616	173	47	proteins	protein	NOUN
ajst-25616	173	48	and	and	CCONJ
ajst-25616	173	49	cutting	cut	VERB
ajst-25616	173	50	methods	method	NOUN
ajst-25616	173	51	.	.	PUNCT
ajst-25616	174	1	these	these	DET
ajst-25616	174	2	technologies	technology	NOUN
ajst-25616	174	3	,	,	PUNCT
ajst-25616	174	4	characterized	characterize	VERB
ajst-25616	174	5	by	by	ADP
ajst-25616	174	6	their	their	PRON
ajst-25616	174	7	single	single	ADJ
ajst-25616	174	8	-	-	PUNCT
ajst-25616	174	9	molecule	molecule	NOUN
ajst-25616	174	10	sequencing	sequencing	NOUN
ajst-25616	174	11	capability	capability	NOUN
ajst-25616	174	12	,	,	PUNCT
ajst-25616	174	13	long	long	ADV
ajst-25616	174	14	read	read	NOUN
ajst-25616	174	15	length	length	NOUN
ajst-25616	174	16	,	,	PUNCT
ajst-25616	174	17	and	and	CCONJ
ajst-25616	174	18	real	real	ADJ
ajst-25616	174	19	-	-	PUNCT
ajst-25616	174	20	time	time	NOUN
ajst-25616	174	21	base	base	NOUN
ajst-25616	174	22	monitoring	monitoring	NOUN
ajst-25616	174	23	,	,	PUNCT
ajst-25616	174	24	have	have	AUX
ajst-25616	174	25	broken	break	VERB
ajst-25616	174	26	through	through	ADP
ajst-25616	174	27	the	the	DET
ajst-25616	174	28	limitations	limitation	NOUN
ajst-25616	174	29	of	of	ADP
ajst-25616	174	30	traditional	traditional	ADJ
ajst-25616	174	31	sequencing	sequence	VERB
ajst-25616	174	32	methods	method	NOUN
ajst-25616	174	33	,	,	PUNCT
ajst-25616	174	34	providing	provide	VERB
ajst-25616	174	35	powerful	powerful	ADJ
ajst-25616	174	36	tools	tool	NOUN
ajst-25616	174	37	for	for	ADP
ajst-25616	174	38	deciphering	decipher	VERB
ajst-25616	174	39	complex	complex	ADJ
ajst-25616	174	40	genomic	genomic	ADJ
ajst-25616	174	41	regions	region	NOUN
ajst-25616	174	42	(	(	PUNCT
ajst-25616	174	43	structural	structural	ADJ
ajst-25616	174	44	variants	variant	NOUN
ajst-25616	174	45	,	,	PUNCT
ajst-25616	174	46	svs	svs	NOUN
ajst-25616	174	47	)	)	PUNCT
ajst-25616	174	48	,	,	PUNCT
ajst-25616	174	49	understanding	understand	VERB
ajst-25616	174	50	gene	gene	NOUN
ajst-25616	174	51	expression	expression	NOUN
ajst-25616	174	52	regulation	regulation	NOUN
ajst-25616	174	53	,	,	PUNCT
ajst-25616	174	54	and	and	CCONJ
ajst-25616	174	55	discovering	discover	VERB
ajst-25616	174	56	new	new	ADJ
ajst-25616	174	57	genetic	genetic	ADJ
ajst-25616	174	58	variations	variation	NOUN
ajst-25616	174	59	.	.	PUNCT
ajst-25616	175	1	references	reference	NOUN
ajst-25616	175	2	[	[	X
ajst-25616	175	3	1	1	NUM
ajst-25616	175	4	]	]	X
ajst-25616	175	5	man	man	NOUN
ajst-25616	175	6	j	j	PROPN
ajst-25616	175	7	c	c	PROPN
ajst-25616	175	8	,	,	PUNCT
ajst-25616	175	9	cheng	cheng	PROPN
ajst-25616	175	10	j	j	PROPN
ajst-25616	175	11	,	,	PUNCT
ajst-25616	175	12	zhao	zhao	PROPN
ajst-25616	175	13	l.	l.	PROPN
ajst-25616	175	14	effect	effect	NOUN
ajst-25616	175	15	of	of	ADP
ajst-25616	175	16	knocking	knock	VERB
ajst-25616	175	17	out	out	ADP
ajst-25616	175	18	hoxa5	hoxa5	PROPN
ajst-25616	175	19	gene	gene	NOUN
ajst-25616	175	20	by	by	ADP
ajst-25616	175	21	crispr	crispr	ADJ
ajst-25616	175	22	-	-	PUNCT
ajst-25616	175	23	cas9	cas9	NOUN
ajst-25616	175	24	-	-	PUNCT
ajst-25616	175	25	mediated	mediate	VERB
ajst-25616	175	26	gene	gene	NOUN
ajst-25616	175	27	editing	edit	VERB
ajst-25616	175	28	technique	technique	NOUN
ajst-25616	175	29	on	on	ADP
ajst-25616	175	30	proliferation	proliferation	NOUN
ajst-25616	175	31	of	of	ADP
ajst-25616	175	32	acute	acute	ADJ
ajst-25616	175	33	myeloid	myeloid	PROPN
ajst-25616	175	34	leukemia	leukemia	PROPN
ajst-25616	175	35	cells[j	cells[j	PROPN
ajst-25616	175	36	]	]	PUNCT
ajst-25616	175	37	.	.	PUNCT
ajst-25616	176	1	zhongguo	zhongguo	PROPN
ajst-25616	176	2	shi	shi	PROPN
ajst-25616	176	3	yan	yan	PROPN
ajst-25616	177	1	xue	xue	PROPN
ajst-25616	177	2	ye	ye	PROPN
ajst-25616	177	3	xue	xue	PROPN
ajst-25616	177	4	za	za	PROPN
ajst-25616	177	5	zhi	zhi	PROPN
ajst-25616	177	6	,	,	PUNCT
ajst-25616	177	7	2024	2024	NUM
ajst-25616	177	8	,	,	PUNCT
ajst-25616	177	9	32(1	32(1	NUM
ajst-25616	177	10	):	):	PUNCT
ajst-25616	177	11	52	52	NUM
ajst-25616	177	12	-	-	SYM
ajst-25616	177	13	56	56	NUM
ajst-25616	177	14	.	.	PUNCT
ajst-25616	178	1	[	[	X
ajst-25616	178	2	2	2	NUM
ajst-25616	178	3	]	]	SYM
ajst-25616	178	4	hu	hu	PROPN
ajst-25616	178	5	sihui	sihui	PROPN
ajst-25616	178	6	,	,	PUNCT
ajst-25616	178	7	liu	liu	PROPN
ajst-25616	178	8	qianyi	qianyi	PROPN
ajst-25616	178	9	,	,	PUNCT
ajst-25616	178	10	xie	xie	PROPN
ajst-25616	178	11	dongchun	dongchun	PROPN
ajst-25616	178	12	,	,	PUNCT
ajst-25616	178	13	et	et	PROPN
ajst-25616	178	14	al	al	PROPN
ajst-25616	178	15	.	.	PROPN
ajst-25616	179	1	clinical	clinical	ADJ
ajst-25616	179	2	research	research	NOUN
ajst-25616	179	3	progress	progress	NOUN
ajst-25616	179	4	of	of	ADP
ajst-25616	179	5	crispr	crispr	ADJ
ajst-25616	179	6	/	/	SYM
ajst-25616	179	7	cas	cas	NOUN
ajst-25616	179	8	genome	genome	NOUN
ajst-25616	179	9	editing	editing	NOUN
ajst-25616	179	10	in	in	ADP
ajst-25616	179	11	the	the	DET
ajst-25616	179	12	treatment	treatment	NOUN
ajst-25616	179	13	of	of	ADP
ajst-25616	179	14	human	human	ADJ
ajst-25616	179	15	genetic	genetic	ADJ
ajst-25616	179	16	disorders[j	disorders[j	PROPN
ajst-25616	179	17	]	]	PUNCT
ajst-25616	179	18	.	.	PUNCT
ajst-25616	180	1	life	life	NOUN
ajst-25616	180	2	sciences	science	NOUN
ajst-25616	180	3	,	,	PUNCT
ajst-25616	180	4	2022,34(10):12501263	2022,34(10):12501263	NUM
ajst-25616	180	5	.	.	PUNCT
ajst-25616	181	1	doi:10.13376	doi:10.13376	NOUN
ajst-25616	181	2	/	/	SYM
ajst-25616	181	3	j.cbls/2022139	j.cbls/2022139	PROPN
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ajst-25616	187	3	-	-	SYM
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ajst-25616	187	5	.	.	PUNCT
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ajst-25616	189	5	.	.	PUNCT
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ajst-25616	191	3	.	.	PUNCT
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ajst-25616	192	2	:	:	PUNCT
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ajst-25616	192	6	-	-	PUNCT
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ajst-25616	192	8	.	.	PUNCT
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ajst-25616	193	2	:	:	PUNCT
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ajst-25616	193	8	.	.	PUNCT
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ajst-25616	194	3	]	]	PUNCT
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ajst-25616	195	8	-	-	PUNCT
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ajst-25616	195	10	.	.	PUNCT
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ajst-25616	196	6	.	.	PUNCT
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ajst-25616	200	3	.	.	PUNCT
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ajst-25616	201	2	:	:	PUNCT
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ajst-25616	202	5	.	.	PUNCT
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ajst-25616	203	2	:	:	PUNCT
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ajst-25616	206	5	.	.	PUNCT
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ajst-25616	211	4	.	.	PUNCT
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ajst-25616	212	8	.	.	PUNCT
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ajst-25616	213	2	:	:	PUNCT
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ajst-25616	216	4	.	.	PUNCT
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ajst-25616	216	10	-	-	PUNCT
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ajst-25616	217	2	:	:	PUNCT
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ajst-25616	226	20	,	,	PUNCT
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ajst-25616	228	4	.	.	PUNCT
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ajst-25616	229	6	-	-	PUNCT
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ajst-25616	229	8	-	-	PUNCT
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ajst-25616	231	20	.	.	PUNCT
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ajst-25616	232	4	,	,	PUNCT
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ajst-25616	232	6	(	(	PUNCT
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ajst-25616	233	2	.	.	PUNCT
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ajst-25616	234	50	.	.	PUNCT
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ajst-25616	244	5	.	.	PUNCT
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ajst-25616	249	6	-	-	SYM
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ajst-25616	249	8	.	.	PUNCT
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ajst-25616	250	6	.	.	PUNCT
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ajst-25616	253	8	;	;	PUNCT
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ajst-25616	253	11	3	3	NUM
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ajst-25616	253	14	.	.	PUNCT
ajst-25616	254	1	doi	doi	NOUN
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ajst-25616	254	4	.	.	PUNCT
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ajst-25616	255	9	.	.	PUNCT
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ajst-25616	257	4	.	.	PUNCT
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ajst-25616	258	4	-	-	NOUN
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ajst-25616	258	6	.	.	PUNCT
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ajst-25616	259	5	.	.	PUNCT
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ajst-25616	260	2	.	.	PUNCT
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ajst-25616	264	4	.	.	PUNCT
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ajst-25616	265	3	-	-	PUNCT
ajst-25616	265	4	22):11871196	22):11871196	NUM
ajst-25616	265	5	.	.	PUNCT
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ajst-25616	266	6	.	.	PUNCT
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ajst-25616	267	2	:	:	PUNCT
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ajst-25616	267	4	;	;	PUNCT
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ajst-25616	267	6	:	:	PUNCT
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ajst-25616	267	8	.	.	PUNCT
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ajst-25616	268	2	20	20	NUM
ajst-25616	268	3	]	]	PUNCT
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ajst-25616	268	9	,	,	PUNCT
ajst-25616	268	10	pullan	pullan	PROPN
ajst-25616	268	11	st	st	PROPN
ajst-25616	268	12	,	,	PUNCT
ajst-25616	268	13	lumley	lumley	PROPN
ajst-25616	268	14	sf	sf	PROPN
ajst-25616	268	15	,	,	PUNCT
ajst-25616	268	16	foster	foster	ADJ
ajst-25616	268	17	d	d	PROPN
ajst-25616	268	18	,	,	PUNCT
ajst-25616	268	19	sanderson	sanderson	PROPN
ajst-25616	268	20	n	n	PRON
ajst-25616	268	21	,	,	PUNCT
ajst-25616	268	22	vaughan	vaughan	PROPN
ajst-25616	268	23	a	a	PROPN
ajst-25616	268	24	,	,	PUNCT
ajst-25616	268	25	morgan	morgan	PROPN
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ajst-25616	268	28	bright	bright	ADJ
ajst-25616	268	29	n	n	CCONJ
ajst-25616	268	30	,	,	PUNCT
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ajst-25616	268	39	,	,	PUNCT
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ajst-25616	268	43	gooch	gooch	PROPN
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ajst-25616	268	45	,	,	PUNCT
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ajst-25616	268	62	pc	pc	PROPN
ajst-25616	268	63	.	.	PUNCT
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ajst-25616	269	12	.	.	PUNCT
ajst-25616	270	1	j	j	PROPN
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ajst-25616	270	4	.	.	PUNCT
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ajst-25616	271	2	dec	dec	PROPN
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ajst-25616	271	4	-	-	SYM
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ajst-25616	271	6	.	.	PUNCT
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ajst-25616	271	10	/	/	SYM
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ajst-25616	271	12	-	-	SYM
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ajst-25616	271	14	.	.	PUNCT
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ajst-25616	272	2	:	:	PUNCT
ajst-25616	272	3	31666364	31666364	NUM
ajst-25616	272	4	;	;	PUNCT
ajst-25616	272	5	pmcid	pmcid	ADJ
ajst-25616	272	6	:	:	PUNCT
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ajst-25616	272	8	.	.	PUNCT
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ajst-25616	273	6	,	,	PUNCT
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ajst-25616	275	3	-	-	SYM
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ajst-25616	275	5	.	.	PUNCT
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ajst-25616	275	11	-	-	PUNCT
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ajst-25616	275	13	-	-	SYM
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ajst-25616	276	5	.	.	PUNCT
ajst-25616	277	1	pmid	pmid	NOUN
ajst-25616	277	2	:	:	PUNCT
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ajst-25616	277	4	;	;	PUNCT
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ajst-25616	278	29	.	.	PUNCT
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ajst-25616	280	4	.	.	PUNCT
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ajst-25616	280	6	:	:	PUNCT
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ajst-25616	280	10	.	.	PUNCT
ajst-25616	281	1	pmid	pmid	NOUN
ajst-25616	281	2	:	:	PUNCT
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ajst-25616	281	4	;	;	PUNCT
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ajst-25616	281	6	:	:	PUNCT
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ajst-25616	283	12	.	.	PUNCT
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ajst-25616	284	11	.	.	PUNCT
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ajst-25616	285	4	;	;	PUNCT
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ajst-25616	285	6	:	:	PUNCT
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ajst-25616	285	8	.	.	PUNCT
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ajst-25616	286	9	,	,	PUNCT
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ajst-25616	286	12	,	,	PUNCT
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ajst-25616	286	27	,	,	PUNCT
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ajst-25616	286	30	,	,	PUNCT
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ajst-25616	286	33	,	,	PUNCT
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ajst-25616	286	90	,	,	PUNCT
ajst-25616	286	91	sun	sun	PROPN
ajst-25616	286	92	a	a	PRON
ajst-25616	286	93	,	,	PUNCT
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ajst-25616	286	95	c	c	PROPN
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ajst-25616	286	102	,	,	PUNCT
ajst-25616	286	103	austin	austin	PROPN
ajst-25616	286	104	sl	sl	PROPN
ajst-25616	286	105	,	,	PUNCT
ajst-25616	286	106	huggins	huggins	PROPN
ajst-25616	286	107	e	e	PROPN
ajst-25616	286	108	,	,	PUNCT
ajst-25616	286	109	safi	safi	PROPN
ajst-25616	286	110	a	a	PROPN
ajst-25616	286	111	,	,	PUNCT
ajst-25616	286	112	iyengar	iyengar	PROPN
ajst-25616	286	113	ak	ak	PROPN
ajst-25616	286	114	,	,	PUNCT
ajst-25616	286	115	reddy	reddy	PROPN
ajst-25616	286	116	te	te	PROPN
ajst-25616	286	117	,	,	PUNCT
ajst-25616	286	118	majoros	majoros	PROPN
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ajst-25616	286	120	,	,	PUNCT
ajst-25616	286	121	allen	allen	VERB
ajst-25616	286	122	as	as	ADP
ajst-25616	286	123	,	,	PUNCT
ajst-25616	286	124	crawford	crawford	PROPN
ajst-25616	286	125	ge	ge	PROPN
ajst-25616	286	126	,	,	PUNCT
ajst-25616	286	127	kishnani	kishnani	PROPN
ajst-25616	286	128	ps	ps	PROPN
ajst-25616	286	129	;	;	PUNCT
ajst-25616	286	130	university	university	PROPN
ajst-25616	286	131	of	of	ADP
ajst-25616	286	132	washington	washington	PROPN
ajst-25616	286	133	center	center	PROPN
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ajst-25616	286	150	nickerson	nickerson	PROPN
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ajst-25616	286	157	d	d	PROPN
ajst-25616	286	158	,	,	PUNCT
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ajst-25616	287	6	identifies	identifie	NOUN
ajst-25616	287	7	missing	miss	VERB
ajst-25616	287	8	disease	disease	NOUN
ajst-25616	287	9	-	-	PUNCT
ajst-25616	287	10	causing	cause	VERB
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ajst-25616	287	12	.	.	PUNCT
ajst-25616	288	1	am	be	AUX
ajst-25616	288	2	j	j	PROPN
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ajst-25616	288	5	.	.	PUNCT
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ajst-25616	289	2	aug	aug	PROPN
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ajst-25616	289	4	-	-	PUNCT
ajst-25616	289	5	1449	1449	NUM
ajst-25616	289	6	.	.	PUNCT
ajst-25616	290	1	doi	doi	NOUN
ajst-25616	290	2	:	:	PUNCT
ajst-25616	290	3	10.1016/	10.1016/	NUM
ajst-25616	290	4	j.ajhg	j.ajhg	NOUN
ajst-25616	290	5	.	.	PUNCT
ajst-25616	291	1	2021.06.006	2021.06.006	NOUN
ajst-25616	291	2	.	.	PUNCT
ajst-25616	292	1	epub	epub	PROPN
ajst-25616	292	2	2021	2021	NUM
ajst-25616	292	3	jul	jul	PROPN
ajst-25616	292	4	2	2	NUM
ajst-25616	292	5	.	.	PUNCT
ajst-25616	292	6	pmid	pmid	NOUN
ajst-25616	292	7	:	:	PUNCT
ajst-25616	292	8	34216551	34216551	NUM
ajst-25616	292	9	;	;	PUNCT
ajst-25616	292	10	pm	pm	NOUN
ajst-25616	292	11	cid	cid	ADJ
ajst-25616	292	12	:	:	PUNCT
ajst-25616	292	13	pmc8387463	pmc8387463	ADJ
ajst-25616	292	14	.	.	PUNCT
ajst-25616	293	1	[	[	X
ajst-25616	293	2	25	25	NUM
ajst-25616	293	3	]	]	X
ajst-25616	293	4	phan	phan	NOUN
ajst-25616	293	5	,	,	PUNCT
ajst-25616	293	6	m.	m.	NOUN
ajst-25616	293	7	;	;	PUNCT
ajst-25616	293	8	gomes	gome	NOUN
ajst-25616	293	9	,	,	PUNCT
ajst-25616	293	10	m.a	m.a	PROPN
ajst-25616	293	11	.	.	PROPN
ajst-25616	293	12	;	;	PUNCT
ajst-25616	293	13	stinnett	stinnett	PROPN
ajst-25616	293	14	,	,	PUNCT
ajst-25616	293	15	v.	v.	PROPN
ajst-25616	293	16	;	;	PUNCT
ajst-25616	293	17	morsberger	morsberger	NOUN
ajst-25616	293	18	,	,	PUNCT
ajst-25616	293	19	l.	l.	PROPN
ajst-25616	293	20	;	;	PUNCT
ajst-25616	293	21	hoppman	hoppman	NOUN
ajst-25616	293	22	,	,	PUNCT
ajst-25616	293	23	n.l	n.l	PROPN
ajst-25616	293	24	.	.	PROPN
ajst-25616	293	25	;	;	PUNCT
ajst-25616	293	26	pearce	pearce	PROPN
ajst-25616	293	27	,	,	PUNCT
ajst-25616	293	28	k.e	k.e	PROPN
ajst-25616	293	29	.	.	PROPN
ajst-25616	293	30	;	;	PUNCT
ajst-25616	293	31	smith	smith	PROPN
ajst-25616	293	32	,	,	PUNCT
ajst-25616	293	33	k.	k.	PROPN
ajst-25616	293	34	;	;	PUNCT
ajst-25616	293	35	phan	phan	PROPN
ajst-25616	293	36	,	,	PUNCT
ajst-25616	293	37	b.	b.	PROPN
ajst-25616	293	38	;	;	PUNCT
ajst-25616	293	39	jiang	jiang	PROPN
ajst-25616	293	40	,	,	PUNCT
ajst-25616	293	41	l.	l.	PROPN
ajst-25616	293	42	;	;	PUNCT
ajst-25616	293	43	zou	zou	PROPN
ajst-25616	293	44	,	,	PUNCT
ajst-25616	293	45	y.s	y.s	PROPN
ajst-25616	293	46	.	.	PROPN
ajst-25616	294	1	an	an	DET
ajst-25616	294	2	integrated	integrated	ADJ
ajst-25616	294	3	approach	approach	NOUN
ajst-25616	294	4	including	include	VERB
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ajst-25616	294	9	sequencing	sequence	VERB
ajst-25616	294	10	,	,	PUNCT
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ajst-25616	294	12	pair	pair	NOUN
ajst-25616	294	13	sequencing	sequencing	NOUN
ajst-25616	294	14	,	,	PUNCT
ajst-25616	294	15	and	and	CCONJ
ajst-25616	294	16	cytogenomic	cytogenomic	ADJ
ajst-25616	294	17	methods	method	NOUN
ajst-25616	294	18	to	to	PART
ajst-25616	294	19	characterize	characterize	VERB
ajst-25616	294	20	complex	complex	ADJ
ajst-25616	294	21	structural	structural	ADJ
ajst-25616	294	22	rearrangements	rearrangement	NOUN
ajst-25616	294	23	in	in	ADP
ajst-25616	294	24	acute	acute	ADJ
ajst-25616	294	25	myeloid	myeloid	ADJ
ajst-25616	294	26	leukemia	leukemia	NOUN
ajst-25616	294	27	.	.	PUNCT
ajst-25616	295	1	biomedicines	biomedicine	VERB
ajst-25616	295	2	2024	2024	NUM
ajst-25616	295	3	,	,	PUNCT
ajst-25616	295	4	12	12	NUM
ajst-25616	295	5	,	,	PUNCT
ajst-25616	295	6	598	598	NUM
ajst-25616	295	7	.	.	PUNCT
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ajst-25616	296	2	.	.	PUNCT
ajst-25616	297	1	[	[	X
ajst-25616	297	2	26	26	NUM
ajst-25616	297	3	]	]	X
ajst-25616	297	4	hafford	hafford	NOUN
ajst-25616	297	5	-	-	PUNCT
ajst-25616	297	6	tear	tear	PROPN
ajst-25616	297	7	nj	nj	PROPN
ajst-25616	297	8	,	,	PUNCT
ajst-25616	297	9	tsai	tsai	PROPN
ajst-25616	297	10	yc	yc	PROPN
ajst-25616	297	11	,	,	PUNCT
ajst-25616	297	12	sadan	sadan	PROPN
ajst-25616	297	13	an	an	PROPN
ajst-25616	297	14	,	,	PUNCT
ajst-25616	297	15	sanchez	sanchez	NOUN
ajst-25616	297	16	-	-	PUNCT
ajst-25616	297	17	pintado	pintado	PROPN
ajst-25616	297	18	b	b	NOUN
ajst-25616	297	19	,	,	PUNCT
ajst-25616	297	20	zarouchlioti	zarouchlioti	PROPN
ajst-25616	297	21	c	c	NOUN
ajst-25616	297	22	,	,	PUNCT
ajst-25616	297	23	maher	maher	PROPN
ajst-25616	297	24	gj	gj	PROPN
ajst-25616	297	25	,	,	PUNCT
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ajst-25616	297	27	p	p	X
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ajst-25616	297	30	sj	sj	PROPN
ajst-25616	297	31	,	,	PUNCT
ajst-25616	297	32	hardcastle	hardcastle	PROPN
ajst-25616	297	33	aj	aj	PROPN
ajst-25616	297	34	,	,	PUNCT
ajst-25616	297	35	clark	clark	PROPN
ajst-25616	297	36	ta	ta	PROPN
ajst-25616	297	37	,	,	PUNCT
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ajst-25616	297	39	ae	ae	PROPN
ajst-25616	297	40	.	.	PUNCT
ajst-25616	298	1	crispr	crispr	PROPN
ajst-25616	298	2	/	/	SYM
ajst-25616	298	3	cas9	cas9	NOUN
ajst-25616	298	4	-	-	PUNCT
ajst-25616	298	5	targeted	target	VERB
ajst-25616	298	6	enrichment	enrichment	NOUN
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ajst-25616	298	9	-	-	PUNCT
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ajst-25616	298	18	-	-	PUNCT
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ajst-25616	298	20	tcf4	tcf4	ADJ
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ajst-25616	298	22	repeat	repeat	NOUN
ajst-25616	298	23	.	.	PUNCT
ajst-25616	299	1	genet	genet	PROPN
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ajst-25616	300	3	-	-	PUNCT
ajst-25616	300	4	2102	2102	NUM
ajst-25616	300	5	.	.	PUNCT
ajst-25616	301	1	doi	doi	NOUN
ajst-25616	301	2	:	:	PUNCT
ajst-25616	301	3	10.1038	10.1038	NUM
ajst-25616	301	4	/	/	SYM
ajst-25616	301	5	s41436	s41436	NOUN
ajst-25616	301	6	-	-	PUNCT
ajst-25616	301	7	019	019	NUM
ajst-25616	301	8	-	-	PUNCT
ajst-25616	301	9	0453	0453	NUM
ajst-25616	301	10	-	-	PUNCT
ajst-25616	301	11	x.	x.	NOUN
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ajst-25616	301	13	2019	2019	NUM
ajst-25616	301	14	feb	feb	NOUN
ajst-25616	301	15	8	8	NUM
ajst-25616	301	16	.	.	PUNCT
ajst-25616	302	1	pmid	pmid	NOUN
ajst-25616	302	2	:	:	PUNCT
ajst-25616	302	3	30733599	30733599	NUM
ajst-25616	302	4	;	;	PUNCT
ajst-25616	302	5	pmcid	pmcid	PROPN
ajst-25616	302	6	:	:	PUNCT
ajst-25616	302	7	pmc6752322	pmc6752322	NOUN
ajst-25616	302	8	.	.	PUNCT
ajst-25616	303	1	[	[	X
ajst-25616	303	2	27	27	NUM
ajst-25616	303	3	]	]	X
ajst-25616	303	4	höijer	höijer	NOUN
ajst-25616	303	5	i	i	PROPN
ajst-25616	303	6	,	,	PUNCT
ajst-25616	303	7	johansson	johansson	PROPN
ajst-25616	303	8	j	j	PROPN
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ajst-25616	303	11	s	s	PROPN
ajst-25616	303	12	,	,	PUNCT
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ajst-25616	303	18	,	,	PUNCT
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ajst-25616	303	30	m	m	PROPN
ajst-25616	303	31	,	,	PUNCT
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ajst-25616	303	33	ml	ml	NOUN
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ajst-25616	303	58	activity	activity	NOUN
ajst-25616	303	59	.	.	PUNCT
ajst-25616	304	1	genome	genome	NOUN
ajst-25616	304	2	biol	biol	NOUN
ajst-25616	304	3	.	.	PUNCT
ajst-25616	305	1	2020	2020	NUM
ajst-25616	305	2	dec	dec	PROPN
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ajst-25616	305	4	.	.	PUNCT
ajst-25616	306	1	doi	doi	NOUN
ajst-25616	306	2	:	:	PUNCT
ajst-25616	306	3	10.1186	10.1186	NUM
ajst-25616	306	4	/	/	SYM
ajst-25616	306	5	s13059	s13059	PROPN
ajst-25616	306	6	-	-	PUNCT
ajst-25616	306	7	020	020	NUM
ajst-25616	306	8	-	-	PUNCT
ajst-25616	306	9	02206	02206	NUM
ajst-25616	306	10	-	-	PUNCT
ajst-25616	306	11	w.	w.	NOUN
ajst-25616	306	12	pmid	pmid	PROPN
ajst-25616	306	13	:	:	PUNCT
ajst-25616	306	14	33261	33261	NUM
ajst-25616	306	15	648	648	NUM
ajst-25616	306	16	;	;	PUNCT
ajst-25616	306	17	pmcid	pmcid	NOUN
ajst-25616	306	18	:	:	PUNCT
ajst-25616	306	19	pmc7706270	pmc7706270	NOUN
ajst-25616	306	20	.	.	PUNCT
ajst-25616	307	1	[	[	X
ajst-25616	307	2	28	28	NUM
ajst-25616	307	3	]	]	X
ajst-25616	307	4	yang	yang	PROPN
ajst-25616	307	5	liu	liu	PROPN
ajst-25616	307	6	,	,	PUNCT
ajst-25616	307	7	yousry	yousry	PROPN
ajst-25616	307	8	a.	a.	PROPN
ajst-25616	307	9	el	el	PROPN
ajst-25616	307	10	-	-	PUNCT
ajst-25616	307	11	kassaby	kassaby	PROPN
ajst-25616	307	12	,	,	PUNCT
ajst-25616	307	13	landscape	landscape	NOUN
ajst-25616	307	14	of	of	ADP
ajst-25616	307	15	fluid	fluid	ADJ
ajst-25616	307	16	sets	set	NOUN
ajst-25616	307	17	of	of	ADP
ajst-25616	307	18	hairpin	hairpin	NOUN
ajst-25616	307	19	-	-	PUNCT
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ajst-25616	307	21	21-/24	21-/24	NUM
ajst-25616	307	22	-	-	PUNCT
ajst-25616	307	23	nt	not	PART
ajst-25616	307	24	-	-	PUNCT
ajst-25616	307	25	long	long	ADJ
ajst-25616	307	26	small	small	ADJ
ajst-25616	307	27	rnas	rna	NOUN
ajst-25616	307	28	at	at	ADP
ajst-25616	307	29	seed	seed	NOUN
ajst-25616	307	30	set	set	VERB
ajst-25616	307	31	uncovers	uncover	NOUN
ajst-25616	307	32	special	special	ADJ
ajst-25616	307	33	epigenetic	epigenetic	ADJ
ajst-25616	307	34	features	feature	NOUN
ajst-25616	307	35	in	in	ADP
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ajst-25616	345	6	.	.	PUNCT
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ajst-25616	346	5	.	.	PUNCT
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ajst-25616	347	2	:	:	PUNCT
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ajst-25616	347	4	.	.	PUNCT
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ajst-25616	348	44	.	.	PUNCT
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ajst-25616	350	5	.	.	PUNCT
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ajst-25616	351	6	.	.	PUNCT
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ajst-25616	352	2	.	.	PUNCT
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ajst-25616	353	5	.	.	PUNCT
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ajst-25616	354	10	.	.	PUNCT
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ajst-25616	357	4	-	-	SYM
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ajst-25616	357	6	.	.	PUNCT
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ajst-25616	363	5	-	-	SYM
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ajst-25616	363	7	.	.	PUNCT
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ajst-25616	364	6	-	-	PUNCT
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ajst-25616	364	8	-	-	PUNCT
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ajst-25616	365	5	.	.	PUNCT
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ajst-25616	366	2	:	:	PUNCT
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ajst-25616	366	4	;	;	PUNCT
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ajst-25616	366	6	:	:	PUNCT
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ajst-25616	366	8	.	.	PUNCT
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ajst-25616	367	30	(	(	PUNCT
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ajst-25616	367	33	.	.	PUNCT
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ajst-25616	368	7	(	(	PUNCT
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ajst-25616	368	11	-	-	SYM
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ajst-25616	368	13	.	.	PUNCT
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ajst-25616	370	5	.	.	PUNCT
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ajst-25616	371	2	:	:	PUNCT
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ajst-25616	371	4	.	.	PUNCT
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ajst-25616	373	21	–	–	PUNCT
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ajst-25616	373	23	-	-	PUNCT
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ajst-25616	373	32	.	.	PUNCT
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ajst-25616	374	5	,	,	PUNCT
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ajst-25616	374	7	(	(	PUNCT
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ajst-25616	374	9	)	)	PUNCT
ajst-25616	374	10	.	.	PUNCT
ajst-25616	375	1	https://doi	https://doi	PROPN
ajst-25616	375	2	.	.	PUNCT
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ajst-25616	376	5	-	-	PUNCT
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ajst-25616	376	7	-	-	PUNCT
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ajst-25616	376	9	-	-	PUNCT
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ajst-25616	377	1	[	[	X
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ajst-25616	377	9	,	,	PUNCT
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ajst-25616	378	18	-	-	PUNCT
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ajst-25616	378	20	-	-	PUNCT
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ajst-25616	378	23	.	.	PUNCT
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ajst-25616	380	4	-	-	SYM
ajst-25616	380	5	8400	8400	NUM
ajst-25616	380	6	.	.	PUNCT
ajst-25616	381	1	doi	doi	NOUN
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ajst-25616	381	4	.	.	PUNCT
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ajst-25616	381	7	.	.	PUNCT
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ajst-25616	382	2	2021	2021	NUM
ajst-25616	382	3	sep	sep	PROPN
ajst-25616	382	4	20	20	NUM
ajst-25616	382	5	.	.	PUNCT
ajst-25616	383	1	pmid	pmid	NOUN
ajst-25616	383	2	:	:	PUNCT
ajst-25616	383	3	3454	3454	NUM
ajst-25616	383	4	2296	2296	NUM
ajst-25616	383	5	.	.	PUNCT
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ajst-25616	384	5	js	js	PROPN
ajst-25616	384	6	,	,	PUNCT
ajst-25616	384	7	abudayyeh	abudayyeh	PROPN
ajst-25616	384	8	oo	oo	PROPN
ajst-25616	384	9	,	,	PUNCT
ajst-25616	384	10	lee	lee	PROPN
ajst-25616	384	11	jw	jw	PROPN
ajst-25616	384	12	,	,	PUNCT
ajst-25616	384	13	essletzbichler	essletzbichler	NOUN
ajst-25616	384	14	p	p	NOUN
ajst-25616	384	15	,	,	PUNCT
ajst-25616	384	16	dy	dy	PROPN
ajst-25616	384	17	aj	aj	PROPN
ajst-25616	384	18	,	,	PUNCT
ajst-25616	384	19	joung	joung	PROPN
ajst-25616	384	20	j	j	PROPN
ajst-25616	384	21	,	,	PUNCT
ajst-25616	384	22	verdine	verdine	NOUN
ajst-25616	384	23	v	v	NOUN
ajst-25616	384	24	,	,	PUNCT
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ajst-25616	384	61	acid	acid	PROPN
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ajst-25616	384	65	-	-	PUNCT
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ajst-25616	384	69	.	.	PUNCT
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ajst-25616	384	71	.	.	PUNCT
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ajst-25616	385	4	-	-	SYM
ajst-25616	385	5	442	442	NUM
ajst-25616	385	6	.	.	PUNCT
ajst-25616	386	1	doi	doi	NOUN
ajst-25616	386	2	:	:	PUNCT
ajst-25616	386	3	10.1126	10.1126	NUM
ajst-25616	386	4	/	/	SYM
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ajst-25616	386	6	.	.	PUNCT
ajst-25616	387	1	aam9321	aam9321	PROPN
ajst-25616	387	2	.	.	PUNCT
ajst-25616	388	1	epub	epub	PROPN
ajst-25616	388	2	2017	2017	NUM
ajst-25616	388	3	apr	apr	NOUN
ajst-25616	388	4	13	13	NUM
ajst-25616	388	5	.	.	PUNCT
ajst-25616	389	1	pmid	pmid	NOUN
ajst-25616	389	2	:	:	PUNCT
ajst-25616	389	3	28408723	28408723	NUM
ajst-25616	389	4	;	;	PUNCT
ajst-25616	389	5	pmcid	pmcid	ADJ
ajst-25616	389	6	:	:	PUNCT
ajst-25616	389	7	pmc5526198	pmc5526198	NOUN
ajst-25616	389	8	.	.	PUNCT
ajst-25616	390	1	[	[	X
ajst-25616	390	2	42	42	NUM
ajst-25616	390	3	]	]	PUNCT
ajst-25616	390	4	sanger	sanger	PROPN
ajst-25616	390	5	f	f	PROPN
ajst-25616	390	6	,	,	PUNCT
ajst-25616	390	7	nicklen	nicklen	VERB
ajst-25616	390	8	s	s	PROPN
ajst-25616	390	9	,	,	PUNCT
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ajst-25616	390	12	.	.	PROPN
ajst-25616	390	13	dna	dna	PROPN
ajst-25616	390	14	sequencing	sequence	VERB
ajst-25616	390	15	with	with	ADP
ajst-25616	390	16	chain	chain	NOUN
ajst-25616	390	17	-	-	PUNCT
ajst-25616	390	18	terminating	terminate	VERB
ajst-25616	390	19	inhibitors	inhibitor	NOUN
ajst-25616	390	20	.	.	PUNCT
ajst-25616	391	1	proc	proc	PROPN
ajst-25616	391	2	natl	natl	PROPN
ajst-25616	391	3	acad	acad	PROPN
ajst-25616	391	4	sci	sci	PROPN
ajst-25616	391	5	u	u	PROPN
ajst-25616	391	6	s	s	PROPN
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ajst-25616	391	8	1977	1977	NUM
ajst-25616	391	9	dec	dec	PROPN
ajst-25616	391	10	;	;	PUNCT
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ajst-25616	391	12	-	-	SYM
ajst-25616	391	13	7	7	NUM
ajst-25616	391	14	.	.	PUNCT
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ajst-25616	391	16	:	:	PUNCT
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ajst-25616	391	20	.	.	PUNCT
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ajst-25616	392	2	:	:	PUNCT
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ajst-25616	392	4	;	;	PUNCT
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ajst-25616	392	6	:	:	PUNCT
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