id	sid	tid	token	lemma	pos
ajst-25617	1	1	academic	academic	ADJ
ajst-25617	1	2	journal	journal	NOUN
ajst-25617	1	3	of	of	ADP
ajst-25617	1	4	science	science	NOUN
ajst-25617	1	5	and	and	CCONJ
ajst-25617	1	6	technology	technology	NOUN
ajst-25617	1	7	issn	issn	NOUN
ajst-25617	1	8	:	:	PUNCT
ajst-25617	1	9	2771	2771	NUM
ajst-25617	1	10	-	-	SYM
ajst-25617	1	11	3032	3032	NUM
ajst-25617	1	12	|	|	NOUN
ajst-25617	1	13	vol	vol	NOUN
ajst-25617	1	14	.	.	PROPN
ajst-25617	2	1	12	12	NUM
ajst-25617	2	2	,	,	PUNCT
ajst-25617	2	3	no	no	INTJ
ajst-25617	2	4	.	.	NOUN
ajst-25617	2	5	2	2	NUM
ajst-25617	2	6	,	,	PUNCT
ajst-25617	2	7	2024	2024	NUM
ajst-25617	2	8	191	191	NUM
ajst-25617	2	9	cell	cell	NOUN
ajst-25617	2	10	immunotherapy	immunotherapy	NOUN
ajst-25617	2	11	:	:	PUNCT
ajst-25617	3	1	principles	principle	NOUN
ajst-25617	3	2	,	,	PUNCT
ajst-25617	3	3	progress	progress	NOUN
ajst-25617	3	4	,	,	PUNCT
ajst-25617	3	5	and	and	CCONJ
ajst-25617	3	6	challenges	challenge	VERB
ajst-25617	3	7	mingwei	mingwei	VERB
ajst-25617	3	8	fan	fan	PROPN
ajst-25617	3	9	*	*	PUNCT
ajst-25617	3	10	edu	edu	PROPN
ajst-25617	3	11	china	china	PROPN
ajst-25617	3	12	international	international	PROPN
ajst-25617	3	13	high	high	ADJ
ajst-25617	3	14	school	school	NOUN
ajst-25617	3	15	,	,	PUNCT
ajst-25617	3	16	100101	100101	NUM
ajst-25617	3	17	,	,	PUNCT
ajst-25617	3	18	china	china	PROPN
ajst-25617	3	19	*	*	PUNCT
ajst-25617	3	20	corresponding	correspond	VERB
ajst-25617	3	21	author	author	NOUN
ajst-25617	3	22	email	email	NOUN
ajst-25617	3	23	:	:	PUNCT
ajst-25617	3	24	19898819300@163.com	19898819300@163.com	NUM
ajst-25617	3	25	abstract	abstract	NOUN
ajst-25617	3	26	:	:	PUNCT
ajst-25617	3	27	cellular	cellular	ADJ
ajst-25617	3	28	immunotherapy	immunotherapy	NOUN
ajst-25617	3	29	refers	refer	VERB
ajst-25617	3	30	to	to	ADP
ajst-25617	3	31	a	a	DET
ajst-25617	3	32	therapeutic	therapeutic	ADJ
ajst-25617	3	33	strategy	strategy	NOUN
ajst-25617	3	34	that	that	PRON
ajst-25617	3	35	harnesses	harness	VERB
ajst-25617	3	36	the	the	DET
ajst-25617	3	37	patient	patient	NOUN
ajst-25617	3	38	's	's	PART
ajst-25617	3	39	immune	immune	ADJ
ajst-25617	3	40	system	system	NOUN
ajst-25617	3	41	for	for	ADP
ajst-25617	3	42	the	the	DET
ajst-25617	3	43	purpose	purpose	NOUN
ajst-25617	3	44	of	of	ADP
ajst-25617	3	45	recognizing	recognize	VERB
ajst-25617	3	46	and	and	CCONJ
ajst-25617	3	47	eliminating	eliminate	VERB
ajst-25617	3	48	malignant	malignant	ADJ
ajst-25617	3	49	cells	cell	NOUN
ajst-25617	3	50	.	.	PUNCT
ajst-25617	4	1	this	this	DET
ajst-25617	4	2	article	article	NOUN
ajst-25617	4	3	provides	provide	VERB
ajst-25617	4	4	an	an	DET
ajst-25617	4	5	overview	overview	NOUN
ajst-25617	4	6	of	of	ADP
ajst-25617	4	7	the	the	DET
ajst-25617	4	8	fundamental	fundamental	ADJ
ajst-25617	4	9	principles	principle	NOUN
ajst-25617	4	10	,	,	PUNCT
ajst-25617	4	11	primary	primary	ADJ
ajst-25617	4	12	classifications	classification	NOUN
ajst-25617	4	13	,	,	PUNCT
ajst-25617	4	14	advancements	advancement	NOUN
ajst-25617	4	15	in	in	ADP
ajst-25617	4	16	clinical	clinical	ADJ
ajst-25617	4	17	implementation	implementation	NOUN
ajst-25617	4	18	,	,	PUNCT
ajst-25617	4	19	obstacles	obstacle	NOUN
ajst-25617	4	20	encountered	encounter	VERB
ajst-25617	4	21	in	in	ADP
ajst-25617	4	22	practice	practice	NOUN
ajst-25617	4	23	,	,	PUNCT
ajst-25617	4	24	as	as	ADV
ajst-25617	4	25	well	well	ADV
ajst-25617	4	26	as	as	ADP
ajst-25617	4	27	potential	potential	ADJ
ajst-25617	4	28	directions	direction	NOUN
ajst-25617	4	29	for	for	ADP
ajst-25617	4	30	future	future	ADJ
ajst-25617	4	31	development	development	NOUN
ajst-25617	4	32	in	in	ADP
ajst-25617	4	33	cellular	cellular	ADJ
ajst-25617	4	34	immunotherapy	immunotherapy	NOUN
ajst-25617	4	35	.	.	PUNCT
ajst-25617	5	1	through	through	ADP
ajst-25617	5	2	in	in	ADP
ajst-25617	5	3	-	-	PUNCT
ajst-25617	5	4	depth	depth	NOUN
ajst-25617	5	5	analysis	analysis	NOUN
ajst-25617	5	6	,	,	PUNCT
ajst-25617	5	7	our	our	PRON
ajst-25617	5	8	goal	goal	NOUN
ajst-25617	5	9	is	be	AUX
ajst-25617	5	10	to	to	PART
ajst-25617	5	11	delve	delve	VERB
ajst-25617	5	12	deeper	deeply	ADV
ajst-25617	5	13	into	into	ADP
ajst-25617	5	14	the	the	DET
ajst-25617	5	15	comprehensive	comprehensive	ADJ
ajst-25617	5	16	knowledge	knowledge	NOUN
ajst-25617	5	17	of	of	ADP
ajst-25617	5	18	cellular	cellular	ADJ
ajst-25617	5	19	immunotherapy	immunotherapy	NOUN
ajst-25617	5	20	and	and	CCONJ
ajst-25617	5	21	look	look	VERB
ajst-25617	5	22	forward	forward	ADV
ajst-25617	5	23	to	to	ADP
ajst-25617	5	24	its	its	PRON
ajst-25617	5	25	potential	potential	ADJ
ajst-25617	5	26	applications	application	NOUN
ajst-25617	5	27	in	in	ADP
ajst-25617	5	28	the	the	DET
ajst-25617	5	29	field	field	NOUN
ajst-25617	5	30	of	of	ADP
ajst-25617	5	31	cancer	cancer	NOUN
ajst-25617	5	32	therapy	therapy	NOUN
ajst-25617	5	33	in	in	ADP
ajst-25617	5	34	the	the	DET
ajst-25617	5	35	future	future	NOUN
ajst-25617	5	36	,	,	PUNCT
ajst-25617	5	37	with	with	ADP
ajst-25617	5	38	a	a	DET
ajst-25617	5	39	view	view	NOUN
ajst-25617	5	40	to	to	ADP
ajst-25617	5	41	opening	open	VERB
ajst-25617	5	42	up	up	ADP
ajst-25617	5	43	new	new	ADJ
ajst-25617	5	44	therapeutic	therapeutic	ADJ
ajst-25617	5	45	avenues	avenue	NOUN
ajst-25617	5	46	.	.	PUNCT
ajst-25617	6	1	keywords	keyword	NOUN
ajst-25617	6	2	:	:	PUNCT
ajst-25617	6	3	cell	cell	NOUN
ajst-25617	6	4	immunotherapy	immunotherapy	NOUN
ajst-25617	6	5	;	;	PUNCT
ajst-25617	6	6	cancer	cancer	NOUN
ajst-25617	6	7	treatment	treatment	NOUN
ajst-25617	6	8	;	;	PUNCT
ajst-25617	6	9	car	car	NOUN
ajst-25617	6	10	-	-	PUNCT
ajst-25617	6	11	t	t	NOUN
ajst-25617	6	12	cells	cell	NOUN
ajst-25617	6	13	;	;	PUNCT
ajst-25617	6	14	tcr	tcr	PROPN
ajst-25617	6	15	-	-	PUNCT
ajst-25617	6	16	t	t	PROPN
ajst-25617	6	17	cells	cell	NOUN
ajst-25617	6	18	;	;	PUNCT
ajst-25617	6	19	immune	immune	ADJ
ajst-25617	6	20	checkpoint	checkpoint	NOUN
ajst-25617	6	21	inhibitors	inhibitor	NOUN
ajst-25617	6	22	.	.	PUNCT
ajst-25617	7	1	1	1	X
ajst-25617	7	2	.	.	X
ajst-25617	7	3	introduction	introduction	NOUN
ajst-25617	7	4	in	in	ADP
ajst-25617	7	5	this	this	DET
ajst-25617	7	6	section	section	NOUN
ajst-25617	7	7	,	,	PUNCT
ajst-25617	7	8	we	we	PRON
ajst-25617	7	9	first	first	ADV
ajst-25617	7	10	introduce	introduce	VERB
ajst-25617	7	11	the	the	DET
ajst-25617	7	12	global	global	ADJ
ajst-25617	7	13	burden	burden	NOUN
ajst-25617	7	14	of	of	ADP
ajst-25617	7	15	cancer	cancer	NOUN
ajst-25617	7	16	and	and	CCONJ
ajst-25617	7	17	the	the	DET
ajst-25617	7	18	limitations	limitation	NOUN
ajst-25617	7	19	of	of	ADP
ajst-25617	7	20	traditional	traditional	ADJ
ajst-25617	7	21	treatment	treatment	NOUN
ajst-25617	7	22	methods	method	NOUN
ajst-25617	7	23	.	.	PUNCT
ajst-25617	8	1	then	then	ADV
ajst-25617	8	2	,	,	PUNCT
ajst-25617	8	3	we	we	PRON
ajst-25617	8	4	present	present	VERB
ajst-25617	8	5	cell	cell	NOUN
ajst-25617	8	6	immunotherapy	immunotherapy	NOUN
ajst-25617	8	7	as	as	ADP
ajst-25617	8	8	an	an	DET
ajst-25617	8	9	emerging	emerge	VERB
ajst-25617	8	10	therapeutic	therapeutic	ADJ
ajst-25617	8	11	approach	approach	NOUN
ajst-25617	8	12	,	,	PUNCT
ajst-25617	8	13	highlighting	highlight	VERB
ajst-25617	8	14	its	its	PRON
ajst-25617	8	15	potential	potential	NOUN
ajst-25617	8	16	and	and	CCONJ
ajst-25617	8	17	importance	importance	NOUN
ajst-25617	8	18	in	in	ADP
ajst-25617	8	19	harnessing	harness	VERB
ajst-25617	8	20	the	the	DET
ajst-25617	8	21	body	body	NOUN
ajst-25617	8	22	's	's	PART
ajst-25617	8	23	own	own	ADJ
ajst-25617	8	24	immune	immune	ADJ
ajst-25617	8	25	system	system	NOUN
ajst-25617	8	26	to	to	PART
ajst-25617	8	27	fight	fight	VERB
ajst-25617	8	28	cancer	cancer	NOUN
ajst-25617	8	29	.	.	PUNCT
ajst-25617	9	1	2	2	X
ajst-25617	9	2	.	.	X
ajst-25617	9	3	cancer	cancer	NOUN
ajst-25617	9	4	as	as	ADP
ajst-25617	9	5	a	a	DET
ajst-25617	9	6	broad	broad	ADJ
ajst-25617	9	7	term	term	NOUN
ajst-25617	9	8	,	,	PUNCT
ajst-25617	9	9	cancer	cancer	NOUN
ajst-25617	9	10	encompasses	encompass	VERB
ajst-25617	9	11	numerous	numerous	ADJ
ajst-25617	9	12	malignant	malignant	ADJ
ajst-25617	9	13	tumors	tumor	NOUN
ajst-25617	9	14	that	that	PRON
ajst-25617	9	15	can	can	AUX
ajst-25617	9	16	develop	develop	VERB
ajst-25617	9	17	in	in	ADP
ajst-25617	9	18	different	different	ADJ
ajst-25617	9	19	organs	organ	NOUN
ajst-25617	9	20	and	and	CCONJ
ajst-25617	9	21	tissues	tissue	NOUN
ajst-25617	9	22	within	within	ADP
ajst-25617	9	23	the	the	DET
ajst-25617	9	24	human	human	ADJ
ajst-25617	9	25	body	body	NOUN
ajst-25617	9	26	.	.	PUNCT
ajst-25617	10	1	currently	currently	ADV
ajst-25617	10	2	,	,	PUNCT
ajst-25617	10	3	cancer	cancer	NOUN
ajst-25617	10	4	is	be	AUX
ajst-25617	10	5	a	a	DET
ajst-25617	10	6	major	major	ADJ
ajst-25617	10	7	global	global	ADJ
ajst-25617	10	8	health	health	NOUN
ajst-25617	10	9	challenge	challenge	NOUN
ajst-25617	10	10	,	,	PUNCT
ajst-25617	10	11	posing	pose	VERB
ajst-25617	10	12	a	a	DET
ajst-25617	10	13	serious	serious	ADJ
ajst-25617	10	14	threat	threat	NOUN
ajst-25617	10	15	to	to	ADP
ajst-25617	10	16	human	human	ADJ
ajst-25617	10	17	health	health	NOUN
ajst-25617	10	18	and	and	CCONJ
ajst-25617	10	19	life	life	NOUN
ajst-25617	10	20	.	.	PUNCT
ajst-25617	11	1	with	with	ADP
ajst-25617	11	2	the	the	DET
ajst-25617	11	3	influence	influence	NOUN
ajst-25617	11	4	of	of	ADP
ajst-25617	11	5	aging	age	VERB
ajst-25617	11	6	population	population	NOUN
ajst-25617	11	7	,	,	PUNCT
ajst-25617	11	8	environmental	environmental	ADJ
ajst-25617	11	9	pollution	pollution	NOUN
ajst-25617	11	10	and	and	CCONJ
ajst-25617	11	11	lifestyle	lifestyle	NOUN
ajst-25617	11	12	changes	change	NOUN
ajst-25617	11	13	,	,	PUNCT
ajst-25617	11	14	the	the	DET
ajst-25617	11	15	incidence	incidence	NOUN
ajst-25617	11	16	of	of	ADP
ajst-25617	11	17	cancer	cancer	NOUN
ajst-25617	11	18	is	be	AUX
ajst-25617	11	19	on	on	ADP
ajst-25617	11	20	the	the	DET
ajst-25617	11	21	rise	rise	NOUN
ajst-25617	11	22	.	.	PUNCT
ajst-25617	12	1	especially	especially	ADV
ajst-25617	12	2	in	in	ADP
ajst-25617	12	3	developing	develop	VERB
ajst-25617	12	4	countries	country	NOUN
ajst-25617	12	5	,	,	PUNCT
ajst-25617	12	6	cancer	cancer	NOUN
ajst-25617	12	7	rates	rate	NOUN
ajst-25617	12	8	are	be	AUX
ajst-25617	12	9	increasing	increase	VERB
ajst-25617	12	10	more	more	ADV
ajst-25617	12	11	dramatically	dramatically	ADV
ajst-25617	12	12	.	.	PUNCT
ajst-25617	13	1	among	among	ADP
ajst-25617	13	2	the	the	DET
ajst-25617	13	3	prevalent	prevalent	ADJ
ajst-25617	13	4	modalities	modality	NOUN
ajst-25617	13	5	for	for	ADP
ajst-25617	13	6	cancer	cancer	NOUN
ajst-25617	13	7	treatment	treatment	NOUN
ajst-25617	13	8	are	be	AUX
ajst-25617	13	9	surgical	surgical	ADJ
ajst-25617	13	10	procedures	procedure	NOUN
ajst-25617	13	11	,	,	PUNCT
ajst-25617	13	12	radiation	radiation	NOUN
ajst-25617	13	13	therapy	therapy	NOUN
ajst-25617	13	14	,	,	PUNCT
ajst-25617	13	15	chemical	chemical	NOUN
ajst-25617	13	16	therapy	therapy	NOUN
ajst-25617	13	17	,	,	PUNCT
ajst-25617	13	18	precision	precision	NOUN
ajst-25617	13	19	-	-	PUNCT
ajst-25617	13	20	targeted	target	VERB
ajst-25617	13	21	therapies	therapy	NOUN
ajst-25617	13	22	,	,	PUNCT
ajst-25617	13	23	immune	immune	NOUN
ajst-25617	13	24	-	-	PUNCT
ajst-25617	13	25	based	base	VERB
ajst-25617	13	26	therapies	therapy	NOUN
ajst-25617	13	27	,	,	PUNCT
ajst-25617	13	28	and	and	CCONJ
ajst-25617	13	29	various	various	ADJ
ajst-25617	13	30	other	other	ADJ
ajst-25617	13	31	approaches	approach	NOUN
ajst-25617	13	32	.	.	PUNCT
ajst-25617	14	1	surgery	surgery	NOUN
ajst-25617	14	2	is	be	AUX
ajst-25617	14	3	a	a	DET
ajst-25617	14	4	common	common	ADJ
ajst-25617	14	5	way	way	NOUN
ajst-25617	14	6	to	to	PART
ajst-25617	14	7	treat	treat	VERB
ajst-25617	14	8	cancer	cancer	NOUN
ajst-25617	14	9	,	,	PUNCT
ajst-25617	14	10	especially	especially	ADV
ajst-25617	14	11	for	for	ADP
ajst-25617	14	12	patients	patient	NOUN
ajst-25617	14	13	with	with	ADP
ajst-25617	14	14	early	early	ADJ
ajst-25617	14	15	detection	detection	NOUN
ajst-25617	14	16	and	and	CCONJ
ajst-25617	14	17	resectable	resectable	VERB
ajst-25617	14	18	local	local	ADJ
ajst-25617	14	19	lesions	lesion	NOUN
ajst-25617	14	20	.	.	PUNCT
ajst-25617	15	1	the	the	DET
ajst-25617	15	2	goal	goal	NOUN
ajst-25617	15	3	of	of	ADP
ajst-25617	15	4	surgery	surgery	NOUN
ajst-25617	15	5	is	be	AUX
ajst-25617	15	6	to	to	PART
ajst-25617	15	7	achieve	achieve	VERB
ajst-25617	15	8	radical	radical	ADJ
ajst-25617	15	9	or	or	CCONJ
ajst-25617	15	10	partial	partial	ADJ
ajst-25617	15	11	removal	removal	NOUN
ajst-25617	15	12	of	of	ADP
ajst-25617	15	13	tumor	tumor	NOUN
ajst-25617	15	14	tissue	tissue	NOUN
ajst-25617	15	15	to	to	PART
ajst-25617	15	16	achieve	achieve	VERB
ajst-25617	15	17	the	the	DET
ajst-25617	15	18	purpose	purpose	NOUN
ajst-25617	15	19	of	of	ADP
ajst-25617	15	20	cancer	cancer	NOUN
ajst-25617	15	21	treatment	treatment	NOUN
ajst-25617	15	22	.	.	PUNCT
ajst-25617	16	1	radiation	radiation	NOUN
ajst-25617	16	2	therapy	therapy	NOUN
ajst-25617	16	3	uses	use	VERB
ajst-25617	16	4	highenergy	highenergy	NOUN
ajst-25617	16	5	rays	ray	NOUN
ajst-25617	16	6	to	to	PART
ajst-25617	16	7	kill	kill	VERB
ajst-25617	16	8	cancer	cancer	NOUN
ajst-25617	16	9	cells	cell	NOUN
ajst-25617	16	10	by	by	ADP
ajst-25617	16	11	destroying	destroy	VERB
ajst-25617	16	12	their	their	PRON
ajst-25617	16	13	dna	dna	NOUN
ajst-25617	16	14	structure	structure	NOUN
ajst-25617	16	15	and	and	CCONJ
ajst-25617	16	16	preventing	prevent	VERB
ajst-25617	16	17	their	their	PRON
ajst-25617	16	18	growth	growth	NOUN
ajst-25617	16	19	and	and	CCONJ
ajst-25617	16	20	division	division	NOUN
ajst-25617	16	21	.	.	PUNCT
ajst-25617	17	1	radiation	radiation	NOUN
ajst-25617	17	2	therapy	therapy	NOUN
ajst-25617	17	3	is	be	AUX
ajst-25617	17	4	a	a	DET
ajst-25617	17	5	common	common	ADJ
ajst-25617	17	6	treatment	treatment	NOUN
ajst-25617	17	7	for	for	ADP
ajst-25617	17	8	cancer	cancer	NOUN
ajst-25617	17	9	that	that	PRON
ajst-25617	17	10	has	have	AUX
ajst-25617	17	11	spread	spread	VERB
ajst-25617	17	12	locally	locally	ADV
ajst-25617	17	13	or	or	CCONJ
ajst-25617	17	14	as	as	ADP
ajst-25617	17	15	a	a	DET
ajst-25617	17	16	preventative	preventative	ADJ
ajst-25617	17	17	measure	measure	NOUN
ajst-25617	17	18	after	after	ADP
ajst-25617	17	19	surgery	surgery	NOUN
ajst-25617	17	20	.	.	PUNCT
ajst-25617	18	1	chemotherapy	chemotherapy	NOUN
ajst-25617	18	2	involves	involve	VERB
ajst-25617	18	3	the	the	DET
ajst-25617	18	4	use	use	NOUN
ajst-25617	18	5	of	of	ADP
ajst-25617	18	6	chemical	chemical	ADJ
ajst-25617	18	7	drugs	drug	NOUN
ajst-25617	18	8	to	to	PART
ajst-25617	18	9	stop	stop	VERB
ajst-25617	18	10	the	the	DET
ajst-25617	18	11	growth	growth	NOUN
ajst-25617	18	12	and	and	CCONJ
ajst-25617	18	13	spread	spread	VERB
ajst-25617	18	14	of	of	ADP
ajst-25617	18	15	cancer	cancer	NOUN
ajst-25617	18	16	cells	cell	NOUN
ajst-25617	18	17	,	,	PUNCT
ajst-25617	18	18	often	often	ADV
ajst-25617	18	19	given	give	VERB
ajst-25617	18	20	through	through	ADP
ajst-25617	18	21	injection	injection	NOUN
ajst-25617	18	22	or	or	CCONJ
ajst-25617	18	23	orally	orally	ADV
ajst-25617	18	24	.	.	PUNCT
ajst-25617	19	1	it	it	PRON
ajst-25617	19	2	can	can	AUX
ajst-25617	19	3	be	be	AUX
ajst-25617	19	4	combined	combine	VERB
ajst-25617	19	5	with	with	ADP
ajst-25617	19	6	radiation	radiation	NOUN
ajst-25617	19	7	therapy	therapy	NOUN
ajst-25617	19	8	or	or	CCONJ
ajst-25617	19	9	surgery	surgery	NOUN
ajst-25617	19	10	to	to	PART
ajst-25617	19	11	improve	improve	VERB
ajst-25617	19	12	outcomes	outcome	NOUN
ajst-25617	19	13	.	.	PUNCT
ajst-25617	20	1	targeted	target	VERB
ajst-25617	20	2	therapy	therapy	NOUN
ajst-25617	20	3	focuses	focus	VERB
ajst-25617	20	4	on	on	ADP
ajst-25617	20	5	specific	specific	ADJ
ajst-25617	20	6	biological	biological	ADJ
ajst-25617	20	7	targets	target	NOUN
ajst-25617	20	8	within	within	ADP
ajst-25617	20	9	cancer	cancer	NOUN
ajst-25617	20	10	cells	cell	NOUN
ajst-25617	20	11	,	,	PUNCT
ajst-25617	20	12	allowing	allow	VERB
ajst-25617	20	13	targeted	target	VERB
ajst-25617	20	14	drugs	drug	NOUN
ajst-25617	20	15	to	to	PART
ajst-25617	20	16	act	act	VERB
ajst-25617	20	17	specifically	specifically	ADV
ajst-25617	20	18	on	on	ADP
ajst-25617	20	19	these	these	DET
ajst-25617	20	20	cells	cell	NOUN
ajst-25617	20	21	while	while	SCONJ
ajst-25617	20	22	minimizing	minimize	VERB
ajst-25617	20	23	harm	harm	NOUN
ajst-25617	20	24	to	to	ADP
ajst-25617	20	25	normal	normal	ADJ
ajst-25617	20	26	cells	cell	NOUN
ajst-25617	20	27	,	,	PUNCT
ajst-25617	20	28	thereby	thereby	ADV
ajst-25617	20	29	improving	improve	VERB
ajst-25617	20	30	treatment	treatment	NOUN
ajst-25617	20	31	effectiveness	effectiveness	NOUN
ajst-25617	20	32	.	.	PUNCT
ajst-25617	21	1	examples	example	NOUN
ajst-25617	21	2	include	include	VERB
ajst-25617	21	3	kinase	kinase	PROPN
ajst-25617	21	4	inhibitors	inhibitor	NOUN
ajst-25617	21	5	and	and	CCONJ
ajst-25617	21	6	anti	anti	ADJ
ajst-25617	21	7	-	-	ADJ
ajst-25617	21	8	angiogenesis	angiogenesis	ADJ
ajst-25617	21	9	inhibitors	inhibitor	NOUN
ajst-25617	21	10	.	.	PUNCT
ajst-25617	22	1	immunotherapy	immunotherapy	NOUN
ajst-25617	22	2	uses	use	VERB
ajst-25617	22	3	the	the	DET
ajst-25617	22	4	patient	patient	NOUN
ajst-25617	22	5	's	's	PART
ajst-25617	22	6	own	own	ADJ
ajst-25617	22	7	immune	immune	ADJ
ajst-25617	22	8	system	system	NOUN
ajst-25617	22	9	to	to	PART
ajst-25617	22	10	fight	fight	VERB
ajst-25617	22	11	against	against	ADP
ajst-25617	22	12	cancer	cancer	NOUN
ajst-25617	22	13	by	by	ADP
ajst-25617	22	14	enhancing	enhance	VERB
ajst-25617	22	15	tumor	tumor	NOUN
ajst-25617	22	16	immunogenicity	immunogenicity	NOUN
ajst-25617	22	17	through	through	ADP
ajst-25617	22	18	molecular	molecular	ADJ
ajst-25617	22	19	biology	biology	NOUN
ajst-25617	22	20	technology	technology	NOUN
ajst-25617	22	21	and	and	CCONJ
ajst-25617	22	22	cell	cell	NOUN
ajst-25617	22	23	engineering	engineering	NOUN
ajst-25617	22	24	techniques	technique	NOUN
ajst-25617	22	25	.	.	PUNCT
ajst-25617	23	1	this	this	DET
ajst-25617	23	2	approach	approach	NOUN
ajst-25617	23	3	supplements	supplement	NOUN
ajst-25617	23	4	adequate	adequate	ADJ
ajst-25617	23	5	amounts	amount	NOUN
ajst-25617	23	6	of	of	ADP
ajst-25617	23	7	normal	normal	ADJ
ajst-25617	23	8	immune	immune	ADJ
ajst-25617	23	9	cells	cell	NOUN
ajst-25617	23	10	and	and	CCONJ
ajst-25617	23	11	related	related	ADJ
ajst-25617	23	12	molecules	molecule	NOUN
ajst-25617	23	13	,	,	PUNCT
ajst-25617	23	14	stimulating	stimulate	VERB
ajst-25617	23	15	and	and	CCONJ
ajst-25617	23	16	strengthening	strengthen	VERB
ajst-25617	23	17	the	the	DET
ajst-25617	23	18	body	body	NOUN
ajst-25617	23	19	's	's	PART
ajst-25617	23	20	anti	anti	ADJ
ajst-25617	23	21	-	-	ADJ
ajst-25617	23	22	tumor	tumor	ADJ
ajst-25617	23	23	immune	immune	ADJ
ajst-25617	23	24	response	response	NOUN
ajst-25617	23	25	while	while	SCONJ
ajst-25617	23	26	increasing	increase	VERB
ajst-25617	23	27	sensitivity	sensitivity	NOUN
ajst-25617	23	28	towards	towards	ADP
ajst-25617	23	29	cancerous	cancerous	ADJ
ajst-25617	23	30	growths	growth	NOUN
ajst-25617	23	31	.	.	PUNCT
ajst-25617	24	1	the	the	DET
ajst-25617	24	2	ultimate	ultimate	ADJ
ajst-25617	24	3	goal	goal	NOUN
ajst-25617	24	4	is	be	AUX
ajst-25617	24	5	complete	complete	ADJ
ajst-25617	24	6	eradication	eradication	NOUN
ajst-25617	24	7	of	of	ADP
ajst-25617	24	8	cancer	cancer	NOUN
ajst-25617	24	9	by	by	ADP
ajst-25617	24	10	inducing	induce	VERB
ajst-25617	24	11	tumor	tumor	NOUN
ajst-25617	24	12	-	-	PUNCT
ajst-25617	24	13	specific	specific	ADJ
ajst-25617	24	14	and	and	CCONJ
ajst-25617	24	15	nonspecific	nonspecific	ADJ
ajst-25617	24	16	effector	effector	NOUN
ajst-25617	24	17	cells	cell	NOUN
ajst-25617	24	18	both	both	CCONJ
ajst-25617	24	19	internally	internally	ADV
ajst-25617	24	20	and	and	CCONJ
ajst-25617	24	21	externally	externally	ADV
ajst-25617	24	22	in	in	ADP
ajst-25617	24	23	order	order	NOUN
ajst-25617	24	24	to	to	PART
ajst-25617	24	25	bolster	bolster	VERB
ajst-25617	24	26	the	the	DET
ajst-25617	24	27	body	body	NOUN
ajst-25617	24	28	's	's	PART
ajst-25617	24	29	ability	ability	NOUN
ajst-25617	24	30	to	to	PART
ajst-25617	24	31	recognize	recognize	VERB
ajst-25617	24	32	and	and	CCONJ
ajst-25617	24	33	eliminate	eliminate	VERB
ajst-25617	24	34	malignant	malignant	ADJ
ajst-25617	24	35	cells	cell	NOUN
ajst-25617	24	36	effectively	effectively	ADV
ajst-25617	24	37	.	.	PUNCT
ajst-25617	25	1	immune	immune	ADJ
ajst-25617	25	2	checkpoint	checkpoint	NOUN
ajst-25617	25	3	inhibitors	inhibitor	NOUN
ajst-25617	25	4	,	,	PUNCT
ajst-25617	25	5	car	car	NOUN
ajst-25617	25	6	-	-	PUNCT
ajst-25617	25	7	t	t	NOUN
ajst-25617	25	8	cell	cell	NOUN
ajst-25617	25	9	therapy	therapy	NOUN
ajst-25617	25	10	,	,	PUNCT
ajst-25617	25	11	cancer	cancer	NOUN
ajst-25617	25	12	vaccines	vaccine	NOUN
ajst-25617	25	13	,	,	PUNCT
ajst-25617	25	14	along	along	ADP
ajst-25617	25	15	with	with	ADP
ajst-25617	25	16	other	other	ADJ
ajst-25617	25	17	strategies	strategy	NOUN
ajst-25617	25	18	that	that	PRON
ajst-25617	25	19	augment	augment	VERB
ajst-25617	25	20	the	the	DET
ajst-25617	25	21	immune	immune	ADJ
ajst-25617	25	22	system	system	NOUN
ajst-25617	25	23	's	's	PART
ajst-25617	25	24	capacity	capacity	NOUN
ajst-25617	25	25	for	for	ADP
ajst-25617	25	26	identifying	identify	VERB
ajst-25617	25	27	and	and	CCONJ
ajst-25617	25	28	destroying	destroy	VERB
ajst-25617	25	29	cancerous	cancerous	ADJ
ajst-25617	25	30	cells	cell	NOUN
ajst-25617	25	31	are	be	AUX
ajst-25617	25	32	included	include	VERB
ajst-25617	25	33	in	in	ADP
ajst-25617	25	34	this	this	DET
ajst-25617	25	35	category	category	NOUN
ajst-25617	25	36	.	.	PUNCT
ajst-25617	26	1	3	3	X
ajst-25617	26	2	.	.	X
ajst-25617	26	3	cellular	cellular	ADJ
ajst-25617	26	4	immunotherapy	immunotherapy	NOUN
ajst-25617	26	5	3.1	3.1	NUM
ajst-25617	26	6	.	.	PUNCT
ajst-25617	26	7	cellular	cellular	ADJ
ajst-25617	26	8	immune	immune	ADJ
ajst-25617	26	9	system	system	NOUN
ajst-25617	26	10	the	the	DET
ajst-25617	26	11	immune	immune	ADJ
ajst-25617	26	12	system	system	NOUN
ajst-25617	26	13	functions	function	NOUN
ajst-25617	26	14	as	as	ADP
ajst-25617	26	15	the	the	DET
ajst-25617	26	16	body	body	NOUN
ajst-25617	26	17	's	's	PART
ajst-25617	26	18	fundamental	fundamental	ADJ
ajst-25617	26	19	line	line	NOUN
ajst-25617	26	20	of	of	ADP
ajst-25617	26	21	defense	defense	NOUN
ajst-25617	26	22	,	,	PUNCT
ajst-25617	26	23	shielding	shield	VERB
ajst-25617	26	24	it	it	PRON
ajst-25617	26	25	from	from	ADP
ajst-25617	26	26	a	a	DET
ajst-25617	26	27	diverse	diverse	ADJ
ajst-25617	26	28	array	array	NOUN
ajst-25617	26	29	of	of	ADP
ajst-25617	26	30	threats	threat	NOUN
ajst-25617	26	31	including	include	VERB
ajst-25617	26	32	bacteria	bacteria	NOUN
ajst-25617	26	33	,	,	PUNCT
ajst-25617	26	34	viruses	virus	NOUN
ajst-25617	26	35	,	,	PUNCT
ajst-25617	26	36	and	and	CCONJ
ajst-25617	26	37	foreign	foreign	ADJ
ajst-25617	26	38	substances	substance	NOUN
ajst-25617	26	39	.	.	PUNCT
ajst-25617	27	1	additionally	additionally	ADV
ajst-25617	27	2	,	,	PUNCT
ajst-25617	27	3	it	it	PRON
ajst-25617	27	4	plays	play	VERB
ajst-25617	27	5	a	a	DET
ajst-25617	27	6	crucial	crucial	ADJ
ajst-25617	27	7	role	role	NOUN
ajst-25617	27	8	in	in	ADP
ajst-25617	27	9	eliminating	eliminate	VERB
ajst-25617	27	10	aging	age	VERB
ajst-25617	27	11	cells	cell	NOUN
ajst-25617	27	12	and	and	CCONJ
ajst-25617	27	13	mutated	mutate	VERB
ajst-25617	27	14	cells	cell	NOUN
ajst-25617	27	15	that	that	PRON
ajst-25617	27	16	may	may	AUX
ajst-25617	27	17	potentially	potentially	ADV
ajst-25617	27	18	develop	develop	VERB
ajst-25617	27	19	into	into	ADP
ajst-25617	27	20	cancerous	cancerous	ADJ
ajst-25617	27	21	cells	cell	NOUN
ajst-25617	27	22	.	.	PUNCT
ajst-25617	28	1	the	the	DET
ajst-25617	28	2	development	development	NOUN
ajst-25617	28	3	of	of	ADP
ajst-25617	28	4	cancer	cancer	NOUN
ajst-25617	28	5	depends	depend	VERB
ajst-25617	28	6	on	on	ADP
ajst-25617	28	7	the	the	DET
ajst-25617	28	8	interaction	interaction	NOUN
ajst-25617	28	9	between	between	ADP
ajst-25617	28	10	cancer	cancer	NOUN
ajst-25617	28	11	cells	cell	NOUN
ajst-25617	28	12	and	and	CCONJ
ajst-25617	28	13	the	the	DET
ajst-25617	28	14	immune	immune	ADJ
ajst-25617	28	15	system	system	NOUN
ajst-25617	28	16	.	.	PUNCT
ajst-25617	29	1	in	in	ADP
ajst-25617	29	2	healthy	healthy	ADJ
ajst-25617	29	3	individuals	individual	NOUN
ajst-25617	29	4	,	,	PUNCT
ajst-25617	29	5	a	a	DET
ajst-25617	29	6	strong	strong	ADJ
ajst-25617	29	7	immune	immune	ADJ
ajst-25617	29	8	system	system	NOUN
ajst-25617	29	9	can	can	AUX
ajst-25617	29	10	efficiently	efficiently	ADV
ajst-25617	29	11	eliminate	eliminate	VERB
ajst-25617	29	12	mutated	mutate	VERB
ajst-25617	29	13	cancer	cancer	NOUN
ajst-25617	29	14	cells	cell	NOUN
ajst-25617	29	15	.	.	PUNCT
ajst-25617	30	1	however	however	ADV
ajst-25617	30	2	,	,	PUNCT
ajst-25617	30	3	individuals	individual	NOUN
ajst-25617	30	4	with	with	ADP
ajst-25617	30	5	cancer	cancer	NOUN
ajst-25617	30	6	often	often	ADV
ajst-25617	30	7	have	have	AUX
ajst-25617	30	8	weakened	weaken	VERB
ajst-25617	30	9	immune	immune	ADJ
ajst-25617	30	10	systems	system	NOUN
ajst-25617	30	11	,	,	PUNCT
ajst-25617	30	12	making	make	VERB
ajst-25617	30	13	it	it	PRON
ajst-25617	30	14	challenging	challenge	VERB
ajst-25617	30	15	for	for	SCONJ
ajst-25617	30	16	them	they	PRON
ajst-25617	30	17	to	to	PART
ajst-25617	30	18	identify	identify	VERB
ajst-25617	30	19	and	and	CCONJ
ajst-25617	30	20	destroy	destroy	VERB
ajst-25617	30	21	cancer	cancer	NOUN
ajst-25617	30	22	cells	cell	NOUN
ajst-25617	30	23	effectively	effectively	ADV
ajst-25617	30	24	.	.	PUNCT
ajst-25617	31	1	moreover	moreover	ADV
ajst-25617	31	2	,	,	PUNCT
ajst-25617	31	3	the	the	DET
ajst-25617	31	4	growth	growth	NOUN
ajst-25617	31	5	of	of	ADP
ajst-25617	31	6	cancer	cancer	NOUN
ajst-25617	31	7	cells	cell	NOUN
ajst-25617	31	8	further	far	ADV
ajst-25617	31	9	suppresses	suppress	VERB
ajst-25617	31	10	the	the	DET
ajst-25617	31	11	patient	patient	NOUN
ajst-25617	31	12	's	's	PART
ajst-25617	31	13	immune	immune	ADJ
ajst-25617	31	14	function	function	NOUN
ajst-25617	31	15	while	while	SCONJ
ajst-25617	31	16	also	also	ADV
ajst-25617	31	17	employing	employ	VERB
ajst-25617	31	18	various	various	ADJ
ajst-25617	31	19	mechanisms	mechanism	NOUN
ajst-25617	31	20	to	to	PART
ajst-25617	31	21	evade	evade	VERB
ajst-25617	31	22	recognition	recognition	NOUN
ajst-25617	31	23	and	and	CCONJ
ajst-25617	31	24	destruction	destruction	NOUN
ajst-25617	31	25	by	by	ADP
ajst-25617	31	26	immune	immune	ADJ
ajst-25617	31	27	cells	cell	NOUN
ajst-25617	31	28	.	.	PUNCT
ajst-25617	32	1	t	t	NOUN
ajst-25617	32	2	-	-	PUNCT
ajst-25617	32	3	cells	cell	NOUN
ajst-25617	32	4	rely	rely	VERB
ajst-25617	32	5	on	on	ADP
ajst-25617	32	6	their	their	PRON
ajst-25617	32	7	surface	surface	NOUN
ajst-25617	32	8	receptors	receptor	NOUN
ajst-25617	32	9	,	,	PUNCT
ajst-25617	32	10	specifically	specifically	ADV
ajst-25617	32	11	the	the	DET
ajst-25617	32	12	tcell	tcell	NOUN
ajst-25617	32	13	receptors	receptor	NOUN
ajst-25617	32	14	(	(	PUNCT
ajst-25617	32	15	tcrs	tcrs	NOUN
ajst-25617	32	16	)	)	PUNCT
ajst-25617	32	17	,	,	PUNCT
ajst-25617	32	18	to	to	PART
ajst-25617	32	19	discern	discern	VERB
ajst-25617	32	20	peptide	peptide	NOUN
ajst-25617	32	21	fragments	fragment	NOUN
ajst-25617	32	22	that	that	PRON
ajst-25617	32	23	are	be	AUX
ajst-25617	32	24	presented	present	VERB
ajst-25617	32	25	by	by	ADP
ajst-25617	32	26	major	major	ADJ
ajst-25617	32	27	histocompatibility	histocompatibility	NOUN
ajst-25617	32	28	complex	complex	NOUN
ajst-25617	32	29	(	(	PUNCT
ajst-25617	32	30	mhc	mhc	NOUN
ajst-25617	32	31	)	)	PUNCT
ajst-25617	32	32	molecules	molecule	NOUN
ajst-25617	32	33	.	.	PUNCT
ajst-25617	33	1	cd8	cd8	PROPN
ajst-25617	33	2	+	+	PROPN
ajst-25617	33	3	cytotoxic	cytotoxic	ADJ
ajst-25617	33	4	t	t	PROPN
ajst-25617	33	5	-	-	PUNCT
ajst-25617	33	6	cells	cell	NOUN
ajst-25617	33	7	are	be	AUX
ajst-25617	33	8	capable	capable	ADJ
ajst-25617	33	9	of	of	ADP
ajst-25617	33	10	identifying	identify	VERB
ajst-25617	33	11	antigens	antigen	NOUN
ajst-25617	33	12	that	that	PRON
ajst-25617	33	13	are	be	AUX
ajst-25617	33	14	displayed	display	VERB
ajst-25617	33	15	on	on	ADP
ajst-25617	33	16	mhc	mhc	PROPN
ajst-25617	33	17	class	class	PROPN
ajst-25617	33	18	i	i	PROPN
ajst-25617	33	19	molecules	molecule	NOUN
ajst-25617	33	20	,	,	PUNCT
ajst-25617	33	21	while	while	SCONJ
ajst-25617	33	22	cd4	cd4	PROPN
ajst-25617	33	23	+	+	PROPN
ajst-25617	33	24	helper	helper	NOUN
ajst-25617	33	25	t	t	PROPN
ajst-25617	33	26	-	-	PUNCT
ajst-25617	33	27	cells	cell	NOUN
ajst-25617	33	28	recognize	recognize	VERB
ajst-25617	33	29	antigens	antigen	NOUN
ajst-25617	33	30	that	that	PRON
ajst-25617	33	31	are	be	AUX
ajst-25617	33	32	exhibited	exhibit	VERB
ajst-25617	33	33	on	on	ADP
ajst-25617	33	34	mhc	mhc	PROPN
ajst-25617	33	35	class	class	PROPN
ajst-25617	33	36	ii	ii	PROPN
ajst-25617	33	37	molecules	molecule	NOUN
ajst-25617	33	38	.	.	PUNCT
ajst-25617	34	1	cancer	cancer	NOUN
ajst-25617	34	2	cells	cell	NOUN
ajst-25617	34	3	may	may	AUX
ajst-25617	34	4	exhibit	exhibit	VERB
ajst-25617	34	5	abnormal	abnormal	ADJ
ajst-25617	34	6	proteins	protein	NOUN
ajst-25617	34	7	or	or	CCONJ
ajst-25617	34	8	protein	protein	NOUN
ajst-25617	34	9	fragments	fragment	NOUN
ajst-25617	34	10	due	due	ADJ
ajst-25617	34	11	to	to	ADP
ajst-25617	34	12	genetic	genetic	ADJ
ajst-25617	34	13	mutations	mutation	NOUN
ajst-25617	34	14	or	or	CCONJ
ajst-25617	34	15	infections	infection	NOUN
ajst-25617	34	16	.	.	PUNCT
ajst-25617	35	1	these	these	DET
ajst-25617	35	2	abnormal	abnormal	ADJ
ajst-25617	35	3	proteins	protein	NOUN
ajst-25617	35	4	are	be	AUX
ajst-25617	35	5	broken	break	VERB
ajst-25617	35	6	down	down	ADP
ajst-25617	35	7	by	by	ADP
ajst-25617	35	8	proteasomes	proteasome	NOUN
ajst-25617	35	9	and	and	CCONJ
ajst-25617	35	10	transported	transport	VERB
ajst-25617	35	11	to	to	ADP
ajst-25617	35	12	the	the	DET
ajst-25617	35	13	endoplasmic	endoplasmic	ADJ
ajst-25617	35	14	reticulum	reticulum	NOUN
ajst-25617	35	15	192	192	NUM
ajst-25617	35	16	through	through	ADP
ajst-25617	35	17	tap	tap	NOUN
ajst-25617	35	18	transporter	transporter	NOUN
ajst-25617	35	19	proteins	protein	NOUN
ajst-25617	35	20	before	before	ADP
ajst-25617	35	21	being	be	AUX
ajst-25617	35	22	presented	present	VERB
ajst-25617	35	23	to	to	ADP
ajst-25617	35	24	cd8+t	cd8+t	NOUN
ajst-25617	35	25	-	-	PUNCT
ajst-25617	35	26	cells	cell	NOUN
ajst-25617	35	27	via	via	ADP
ajst-25617	35	28	mhc	mhc	PROPN
ajst-25617	35	29	class	class	PROPN
ajst-25617	35	30	i	i	PROPN
ajst-25617	35	31	molecules	molecule	NOUN
ajst-25617	35	32	.	.	PUNCT
ajst-25617	36	1	natural	natural	ADJ
ajst-25617	36	2	killer	killer	NOUN
ajst-25617	36	3	(	(	PUNCT
ajst-25617	36	4	nk	nk	PROPN
ajst-25617	36	5	)	)	PUNCT
ajst-25617	36	6	cells	cell	NOUN
ajst-25617	36	7	:	:	PUNCT
ajst-25617	36	8	nk	nk	PROPN
ajst-25617	36	9	cells	cell	NOUN
ajst-25617	36	10	identify	identify	VERB
ajst-25617	36	11	cancerous	cancerous	ADJ
ajst-25617	36	12	cells	cell	NOUN
ajst-25617	36	13	by	by	ADP
ajst-25617	36	14	detecting	detect	VERB
ajst-25617	36	15	those	those	DET
ajst-25617	36	16	lacking	lack	VERB
ajst-25617	36	17	mhc	mhc	PROPN
ajst-25617	36	18	class	class	NOUN
ajst-25617	36	19	i	i	PROPN
ajst-25617	36	20	molecules	molecule	NOUN
ajst-25617	36	21	.	.	PUNCT
ajst-25617	37	1	maintaining	maintain	VERB
ajst-25617	37	2	normal	normal	ADJ
ajst-25617	37	3	expression	expression	NOUN
ajst-25617	37	4	of	of	ADP
ajst-25617	37	5	mhc	mhc	PROPN
ajst-25617	37	6	class	class	NOUN
ajst-25617	37	7	i	i	PRON
ajst-25617	37	8	molecules	molecule	NOUN
ajst-25617	37	9	is	be	AUX
ajst-25617	37	10	crucial	crucial	ADJ
ajst-25617	37	11	in	in	ADP
ajst-25617	37	12	suppressing	suppress	VERB
ajst-25617	37	13	nk	nk	PROPN
ajst-25617	37	14	cell	cell	NOUN
ajst-25617	37	15	activation	activation	NOUN
ajst-25617	37	16	.	.	PUNCT
ajst-25617	38	1	when	when	SCONJ
ajst-25617	38	2	attempting	attempt	VERB
ajst-25617	38	3	to	to	PART
ajst-25617	38	4	evade	evade	VERB
ajst-25617	38	5	the	the	DET
ajst-25617	38	6	immune	immune	ADJ
ajst-25617	38	7	system	system	NOUN
ajst-25617	38	8	,	,	PUNCT
ajst-25617	38	9	cancerous	cancerous	ADJ
ajst-25617	38	10	cells	cell	NOUN
ajst-25617	38	11	reduce	reduce	VERB
ajst-25617	38	12	their	their	PRON
ajst-25617	38	13	expression	expression	NOUN
ajst-25617	38	14	of	of	ADP
ajst-25617	38	15	mhc	mhc	PROPN
ajst-25617	38	16	class	class	NOUN
ajst-25617	38	17	i	i	PRON
ajst-25617	38	18	molecules	molecule	NOUN
ajst-25617	38	19	which	which	PRON
ajst-25617	38	20	inadvertently	inadvertently	ADV
ajst-25617	38	21	exposes	expose	VERB
ajst-25617	38	22	them	they	PRON
ajst-25617	38	23	to	to	PART
ajst-25617	38	24	surveillance	surveillance	NOUN
ajst-25617	38	25	by	by	ADP
ajst-25617	38	26	nk	nk	PROPN
ajst-25617	38	27	cells	cell	NOUN
ajst-25617	38	28	3.2	3.2	NUM
ajst-25617	38	29	.	.	PUNCT
ajst-25617	39	1	cancer	cancer	NOUN
ajst-25617	39	2	cells	cell	NOUN
ajst-25617	39	3	evading	evade	VERB
ajst-25617	39	4	immune	immune	ADJ
ajst-25617	39	5	surveillance	surveillance	NOUN
ajst-25617	39	6	t	t	NOUN
ajst-25617	39	7	lymphocytes	lymphocyte	NOUN
ajst-25617	39	8	employ	employ	VERB
ajst-25617	39	9	their	their	PRON
ajst-25617	39	10	t	t	NOUN
ajst-25617	39	11	cell	cell	NOUN
ajst-25617	39	12	receptors	receptor	NOUN
ajst-25617	39	13	(	(	PUNCT
ajst-25617	39	14	tcrs	tcrs	NOUN
ajst-25617	39	15	)	)	PUNCT
ajst-25617	39	16	on	on	ADP
ajst-25617	39	17	the	the	DET
ajst-25617	39	18	surface	surface	NOUN
ajst-25617	39	19	to	to	PART
ajst-25617	39	20	identify	identify	VERB
ajst-25617	39	21	peptide	peptide	ADJ
ajst-25617	39	22	fragments	fragment	NOUN
ajst-25617	39	23	that	that	PRON
ajst-25617	39	24	are	be	AUX
ajst-25617	39	25	displayed	display	VERB
ajst-25617	39	26	by	by	ADP
ajst-25617	39	27	major	major	ADJ
ajst-25617	39	28	histocompatibility	histocompatibility	NOUN
ajst-25617	39	29	complex	complex	NOUN
ajst-25617	39	30	(	(	PUNCT
ajst-25617	39	31	mhc	mhc	NOUN
ajst-25617	39	32	)	)	PUNCT
ajst-25617	39	33	molecules	molecule	NOUN
ajst-25617	39	34	.	.	PUNCT
ajst-25617	40	1	cd8	cd8	PROPN
ajst-25617	40	2	+	+	PROPN
ajst-25617	40	3	cytotoxic	cytotoxic	ADJ
ajst-25617	40	4	t	t	NOUN
ajst-25617	40	5	cells	cell	NOUN
ajst-25617	40	6	recognize	recognize	VERB
ajst-25617	40	7	antigens	antigen	NOUN
ajst-25617	40	8	exhibited	exhibit	VERB
ajst-25617	40	9	on	on	ADP
ajst-25617	40	10	mhc	mhc	PROPN
ajst-25617	40	11	class	class	PROPN
ajst-25617	40	12	i	i	PROPN
ajst-25617	40	13	molecules	molecule	NOUN
ajst-25617	40	14	,	,	PUNCT
ajst-25617	40	15	whereas	whereas	SCONJ
ajst-25617	40	16	cd4	cd4	PROPN
ajst-25617	40	17	+	+	PROPN
ajst-25617	40	18	helper	helper	NOUN
ajst-25617	40	19	t	t	PROPN
ajst-25617	40	20	cells	cell	NOUN
ajst-25617	40	21	acknowledge	acknowledge	VERB
ajst-25617	40	22	antigens	antigen	NOUN
ajst-25617	40	23	presented	present	VERB
ajst-25617	40	24	on	on	ADP
ajst-25617	40	25	mhc	mhc	PROPN
ajst-25617	40	26	class	class	PROPN
ajst-25617	40	27	ii	ii	PROPN
ajst-25617	40	28	molecules	molecule	NOUN
ajst-25617	40	29	.	.	PUNCT
ajst-25617	41	1	abnormal	abnormal	ADJ
ajst-25617	41	2	proteins	protein	NOUN
ajst-25617	41	3	or	or	CCONJ
ajst-25617	41	4	protein	protein	NOUN
ajst-25617	41	5	fragments	fragment	NOUN
ajst-25617	41	6	may	may	AUX
ajst-25617	41	7	be	be	AUX
ajst-25617	41	8	expressed	express	VERB
ajst-25617	41	9	by	by	ADP
ajst-25617	41	10	cancerous	cancerous	ADJ
ajst-25617	41	11	cells	cell	NOUN
ajst-25617	41	12	as	as	ADP
ajst-25617	41	13	a	a	DET
ajst-25617	41	14	result	result	NOUN
ajst-25617	41	15	of	of	ADP
ajst-25617	41	16	genetic	genetic	ADJ
ajst-25617	41	17	mutations	mutation	NOUN
ajst-25617	41	18	or	or	CCONJ
ajst-25617	41	19	infections	infection	NOUN
ajst-25617	41	20	.	.	PUNCT
ajst-25617	42	1	these	these	DET
ajst-25617	42	2	atypical	atypical	ADJ
ajst-25617	42	3	proteins	protein	NOUN
ajst-25617	42	4	undergo	undergo	VERB
ajst-25617	42	5	degradation	degradation	NOUN
ajst-25617	42	6	by	by	ADP
ajst-25617	42	7	the	the	DET
ajst-25617	42	8	proteasome	proteasome	NOUN
ajst-25617	42	9	and	and	CCONJ
ajst-25617	42	10	are	be	AUX
ajst-25617	42	11	subsequently	subsequently	ADV
ajst-25617	42	12	transported	transport	VERB
ajst-25617	42	13	to	to	ADP
ajst-25617	42	14	the	the	DET
ajst-25617	42	15	endoplasmic	endoplasmic	ADJ
ajst-25617	42	16	reticulum	reticulum	NOUN
ajst-25617	42	17	through	through	ADP
ajst-25617	42	18	tap	tap	NOUN
ajst-25617	42	19	transporter	transporter	NOUN
ajst-25617	42	20	proteins	protein	NOUN
ajst-25617	42	21	before	before	ADP
ajst-25617	42	22	being	be	AUX
ajst-25617	42	23	presented	present	VERB
ajst-25617	42	24	to	to	ADP
ajst-25617	42	25	cd8+t	cd8+t	NOUN
ajst-25617	42	26	cells	cell	NOUN
ajst-25617	42	27	via	via	ADP
ajst-25617	42	28	mhc	mhc	PROPN
ajst-25617	42	29	class	class	PROPN
ajst-25617	42	30	i	i	PROPN
ajst-25617	42	31	molecules	molecule	NOUN
ajst-25617	42	32	.	.	PUNCT
ajst-25617	43	1	3.3	3.3	NUM
ajst-25617	43	2	.	.	PUNCT
ajst-25617	44	1	cellular	cellular	ADJ
ajst-25617	44	2	immunotherapy	immunotherapy	NOUN
ajst-25617	44	3	cellular	cellular	ADJ
ajst-25617	44	4	immunotherapy	immunotherapy	NOUN
ajst-25617	44	5	entails	entail	VERB
ajst-25617	44	6	the	the	DET
ajst-25617	44	7	extraction	extraction	NOUN
ajst-25617	44	8	of	of	ADP
ajst-25617	44	9	immune	immune	ADJ
ajst-25617	44	10	cells	cell	NOUN
ajst-25617	44	11	from	from	ADP
ajst-25617	44	12	the	the	DET
ajst-25617	44	13	human	human	ADJ
ajst-25617	44	14	body	body	NOUN
ajst-25617	44	15	,	,	PUNCT
ajst-25617	44	16	their	their	PRON
ajst-25617	44	17	cultivation	cultivation	NOUN
ajst-25617	44	18	in	in	ADP
ajst-25617	44	19	a	a	DET
ajst-25617	44	20	laboratory	laboratory	NOUN
ajst-25617	44	21	to	to	PART
ajst-25617	44	22	amplify	amplify	VERB
ajst-25617	44	23	their	their	PRON
ajst-25617	44	24	numbers	number	NOUN
ajst-25617	44	25	and	and	CCONJ
ajst-25617	44	26	enhance	enhance	VERB
ajst-25617	44	27	their	their	PRON
ajst-25617	44	28	targeted	target	VERB
ajst-25617	44	29	killing	kill	VERB
ajst-25617	44	30	capabilities	capability	NOUN
ajst-25617	44	31	,	,	PUNCT
ajst-25617	44	32	and	and	CCONJ
ajst-25617	44	33	subsequently	subsequently	ADV
ajst-25617	44	34	reintroducing	reintroduce	VERB
ajst-25617	44	35	them	they	PRON
ajst-25617	44	36	into	into	ADP
ajst-25617	44	37	the	the	DET
ajst-25617	44	38	body	body	NOUN
ajst-25617	44	39	to	to	PART
ajst-25617	44	40	eliminate	eliminate	VERB
ajst-25617	44	41	pathogens	pathogen	NOUN
ajst-25617	44	42	,	,	PUNCT
ajst-25617	44	43	cancer	cancer	NOUN
ajst-25617	44	44	cells	cell	NOUN
ajst-25617	44	45	,	,	PUNCT
ajst-25617	44	46	and	and	CCONJ
ajst-25617	44	47	mutated	mutate	VERB
ajst-25617	44	48	cells	cell	NOUN
ajst-25617	44	49	present	present	ADJ
ajst-25617	44	50	in	in	ADP
ajst-25617	44	51	the	the	DET
ajst-25617	44	52	bloodstream	bloodstream	NOUN
ajst-25617	44	53	and	and	CCONJ
ajst-25617	44	54	tissues	tissue	NOUN
ajst-25617	44	55	.	.	PUNCT
ajst-25617	45	1	this	this	DET
ajst-25617	45	2	procedure	procedure	NOUN
ajst-25617	45	3	disrupts	disrupt	VERB
ajst-25617	45	4	immune	immune	ADJ
ajst-25617	45	5	tolerance	tolerance	NOUN
ajst-25617	45	6	,	,	PUNCT
ajst-25617	45	7	activates	activate	VERB
ajst-25617	45	8	and	and	CCONJ
ajst-25617	45	9	boosts	boost	VERB
ajst-25617	45	10	the	the	DET
ajst-25617	45	11	body	body	NOUN
ajst-25617	45	12	's	's	PART
ajst-25617	45	13	immune	immune	ADJ
ajst-25617	45	14	function	function	NOUN
ajst-25617	45	15	,	,	PUNCT
ajst-25617	45	16	serving	serve	VERB
ajst-25617	45	17	both	both	PRON
ajst-25617	45	18	as	as	ADP
ajst-25617	45	19	a	a	DET
ajst-25617	45	20	treatment	treatment	NOUN
ajst-25617	45	21	method	method	NOUN
ajst-25617	45	22	and	and	CCONJ
ajst-25617	45	23	a	a	DET
ajst-25617	45	24	means	means	NOUN
ajst-25617	45	25	of	of	ADP
ajst-25617	45	26	promoting	promote	VERB
ajst-25617	45	27	overall	overall	ADJ
ajst-25617	45	28	health	health	NOUN
ajst-25617	45	29	.	.	PUNCT
ajst-25617	46	1	t	t	PROPN
ajst-25617	46	2	lymphocytes	lymphocyte	VERB
ajst-25617	46	3	(	(	PUNCT
ajst-25617	46	4	t	t	NOUN
ajst-25617	46	5	cells	cell	NOUN
ajst-25617	46	6	)	)	PUNCT
ajst-25617	46	7	play	play	VERB
ajst-25617	46	8	a	a	DET
ajst-25617	46	9	pivotal	pivotal	ADJ
ajst-25617	46	10	role	role	NOUN
ajst-25617	46	11	in	in	ADP
ajst-25617	46	12	the	the	DET
ajst-25617	46	13	immune	immune	ADJ
ajst-25617	46	14	system	system	NOUN
ajst-25617	46	15	,	,	PUNCT
ajst-25617	46	16	particularly	particularly	ADV
ajst-25617	46	17	in	in	ADP
ajst-25617	46	18	mounting	mount	VERB
ajst-25617	46	19	an	an	DET
ajst-25617	46	20	anti	anti	ADJ
ajst-25617	46	21	-	-	ADJ
ajst-25617	46	22	cancer	cancer	ADJ
ajst-25617	46	23	immune	immune	ADJ
ajst-25617	46	24	response	response	NOUN
ajst-25617	46	25	.	.	PUNCT
ajst-25617	47	1	they	they	PRON
ajst-25617	47	2	constitute	constitute	VERB
ajst-25617	47	3	an	an	DET
ajst-25617	47	4	essential	essential	ADJ
ajst-25617	47	5	component	component	NOUN
ajst-25617	47	6	of	of	ADP
ajst-25617	47	7	the	the	DET
ajst-25617	47	8	adaptive	adaptive	ADJ
ajst-25617	47	9	immune	immune	ADJ
ajst-25617	47	10	system	system	NOUN
ajst-25617	47	11	with	with	ADP
ajst-25617	47	12	the	the	DET
ajst-25617	47	13	ability	ability	NOUN
ajst-25617	47	14	to	to	PART
ajst-25617	47	15	identify	identify	VERB
ajst-25617	47	16	and	and	CCONJ
ajst-25617	47	17	eradicate	eradicate	VERB
ajst-25617	47	18	infected	infect	VERB
ajst-25617	47	19	or	or	CCONJ
ajst-25617	47	20	cancerous	cancerous	ADJ
ajst-25617	47	21	cells	cell	NOUN
ajst-25617	47	22	.	.	PUNCT
ajst-25617	48	1	through	through	ADP
ajst-25617	48	2	cellular	cellular	ADJ
ajst-25617	48	3	immunotherapy	immunotherapy	NOUN
ajst-25617	48	4	,	,	PUNCT
ajst-25617	48	5	we	we	PRON
ajst-25617	48	6	can	can	AUX
ajst-25617	48	7	augment	augment	VERB
ajst-25617	48	8	t	t	PROPN
ajst-25617	48	9	cellmediated	cellmediate	VERB
ajst-25617	48	10	anti	anti	ADJ
ajst-25617	48	11	-	-	ADJ
ajst-25617	48	12	cancer	cancer	ADJ
ajst-25617	48	13	activity	activity	NOUN
ajst-25617	48	14	effectively	effectively	ADV
ajst-25617	48	15	combating	combat	VERB
ajst-25617	48	16	cancer	cancer	NOUN
ajst-25617	48	17	.	.	PUNCT
ajst-25617	49	1	t	t	NOUN
ajst-25617	49	2	cells	cell	NOUN
ajst-25617	49	3	possess	possess	VERB
ajst-25617	49	4	recognition	recognition	NOUN
ajst-25617	49	5	abilities	ability	NOUN
ajst-25617	49	6	enabling	enable	VERB
ajst-25617	49	7	them	they	PRON
ajst-25617	49	8	to	to	PART
ajst-25617	49	9	target	target	VERB
ajst-25617	49	10	abnormal	abnormal	ADJ
ajst-25617	49	11	cells	cell	NOUN
ajst-25617	49	12	within	within	ADP
ajst-25617	49	13	the	the	DET
ajst-25617	49	14	body	body	NOUN
ajst-25617	49	15	including	include	VERB
ajst-25617	49	16	cancerous	cancerous	ADJ
ajst-25617	49	17	ones	one	NOUN
ajst-25617	49	18	by	by	ADP
ajst-25617	49	19	identifying	identify	VERB
ajst-25617	49	20	specific	specific	ADJ
ajst-25617	49	21	antigens	antigen	NOUN
ajst-25617	49	22	on	on	ADP
ajst-25617	49	23	their	their	PRON
ajst-25617	49	24	surface	surface	NOUN
ajst-25617	49	25	such	such	ADJ
ajst-25617	49	26	as	as	ADP
ajst-25617	49	27	tumorassociated	tumorassociate	VERB
ajst-25617	49	28	antigens	antigen	NOUN
ajst-25617	49	29	(	(	PUNCT
ajst-25617	49	30	taa	taa	X
ajst-25617	49	31	)	)	PUNCT
ajst-25617	49	32	along	along	ADP
ajst-25617	49	33	with	with	ADP
ajst-25617	49	34	novel	novel	ADJ
ajst-25617	49	35	antigens	antigen	NOUN
ajst-25617	49	36	thereby	thereby	ADV
ajst-25617	49	37	determining	determine	VERB
ajst-25617	49	38	their	their	PRON
ajst-25617	49	39	location	location	NOUN
ajst-25617	49	40	for	for	ADP
ajst-25617	49	41	elimination	elimination	NOUN
ajst-25617	49	42	purposes	purpose	NOUN
ajst-25617	49	43	.	.	PUNCT
ajst-25617	50	1	the	the	DET
ajst-25617	50	2	cytotoxic	cytotoxic	ADJ
ajst-25617	50	3	function	function	NOUN
ajst-25617	50	4	primarily	primarily	ADV
ajst-25617	50	5	executed	execute	VERB
ajst-25617	50	6	by	by	ADP
ajst-25617	50	7	cd8+t	cd8+t	NOUN
ajst-25617	50	8	cells	cell	NOUN
ajst-25617	50	9	(	(	PUNCT
ajst-25617	50	10	cytotoxic	cytotoxic	ADJ
ajst-25617	50	11	t	t	NOUN
ajst-25617	50	12	lymphocytes	lymphocyte	VERB
ajst-25617	50	13	)	)	PUNCT
ajst-25617	50	14	involves	involve	VERB
ajst-25617	50	15	direct	direct	ADJ
ajst-25617	50	16	eradication	eradication	NOUN
ajst-25617	50	17	of	of	ADP
ajst-25617	50	18	cancerous	cancerous	ADJ
ajst-25617	50	19	cells	cell	NOUN
ajst-25617	50	20	.	.	PUNCT
ajst-25617	51	1	approaches	approach	NOUN
ajst-25617	51	2	aimed	aim	VERB
ajst-25617	51	3	at	at	ADP
ajst-25617	51	4	enhancing	enhance	VERB
ajst-25617	51	5	t	t	PROPN
ajst-25617	51	6	cell	cell	NOUN
ajst-25617	51	7	anticancer	anticancer	NOUN
ajst-25617	51	8	efficacy	efficacy	NOUN
ajst-25617	51	9	encompass	encompass	NOUN
ajst-25617	51	10	:	:	PUNCT
ajst-25617	51	11	car	car	NOUN
ajst-25617	51	12	-	-	PUNCT
ajst-25617	51	13	t	t	NOUN
ajst-25617	51	14	cell	cell	NOUN
ajst-25617	51	15	therapy	therapy	NOUN
ajst-25617	51	16	:	:	PUNCT
ajst-25617	51	17	this	this	DET
ajst-25617	51	18	therapeutic	therapeutic	ADJ
ajst-25617	51	19	approach	approach	NOUN
ajst-25617	51	20	employs	employ	VERB
ajst-25617	51	21	genetic	genetic	ADJ
ajst-25617	51	22	modification	modification	NOUN
ajst-25617	51	23	techniques	technique	NOUN
ajst-25617	51	24	altering	alter	VERB
ajst-25617	51	25	t	t	PROPN
ajst-25617	51	26	cell	cell	NOUN
ajst-25617	51	27	characteristics	characteristic	NOUN
ajst-25617	51	28	resulting	result	VERB
ajst-25617	51	29	in	in	ADP
ajst-25617	51	30	expression	expression	NOUN
ajst-25617	51	31	of	of	ADP
ajst-25617	51	32	chimeric	chimeric	ADJ
ajst-25617	51	33	antigen	antigen	ADJ
ajst-25617	51	34	receptors	receptor	NOUN
ajst-25617	51	35	(	(	PUNCT
ajst-25617	51	36	cars	car	NOUN
ajst-25617	51	37	)	)	PUNCT
ajst-25617	51	38	,	,	PUNCT
ajst-25617	51	39	thus	thus	ADV
ajst-25617	51	40	rendering	render	VERB
ajst-25617	51	41	them	they	PRON
ajst-25617	51	42	more	more	ADV
ajst-25617	51	43	precise	precise	ADJ
ajst-25617	51	44	in	in	ADP
ajst-25617	51	45	targeting	target	VERB
ajst-25617	51	46	and	and	CCONJ
ajst-25617	51	47	attacking	attack	VERB
ajst-25617	51	48	malignant	malignant	ADJ
ajst-25617	51	49	neoplastic	neoplastic	ADJ
ajst-25617	51	50	growth	growth	NOUN
ajst-25617	51	51	.	.	PUNCT
ajst-25617	52	1	tcr	tcr	PROPN
ajst-25617	52	2	-	-	PUNCT
ajst-25617	52	3	t	t	PROPN
ajst-25617	52	4	cell	cell	NOUN
ajst-25617	52	5	therapy	therapy	NOUN
ajst-25617	52	6	:	:	PUNCT
ajst-25617	52	7	this	this	DET
ajst-25617	52	8	therapy	therapy	NOUN
ajst-25617	52	9	focuses	focus	VERB
ajst-25617	52	10	on	on	ADP
ajst-25617	52	11	modifying	modify	VERB
ajst-25617	52	12	t	t	NOUN
ajst-25617	52	13	cell	cell	NOUN
ajst-25617	52	14	receptors	receptor	NOUN
ajst-25617	52	15	(	(	PUNCT
ajst-25617	52	16	tcrs	tcrs	NOUN
ajst-25617	52	17	)	)	PUNCT
ajst-25617	52	18	enabling	enable	VERB
ajst-25617	52	19	recognition	recognition	NOUN
ajst-25617	52	20	of	of	ADP
ajst-25617	52	21	specific	specific	ADJ
ajst-25617	52	22	tumor	tumor	NOUN
ajst-25617	52	23	antigens	antigen	NOUN
ajst-25617	52	24	while	while	SCONJ
ajst-25617	52	25	concurrently	concurrently	ADV
ajst-25617	52	26	bolstering	bolster	VERB
ajst-25617	52	27	their	their	PRON
ajst-25617	52	28	capacity	capacity	NOUN
ajst-25617	52	29	to	to	PART
ajst-25617	52	30	combat	combat	NOUN
ajst-25617	52	31	malignancies	malignancy	NOUN
ajst-25617	52	32	.	.	PUNCT
ajst-25617	53	1	immune	immune	ADJ
ajst-25617	53	2	checkpoint	checkpoint	NOUN
ajst-25617	53	3	inhibitors	inhibitor	NOUN
ajst-25617	53	4	are	be	AUX
ajst-25617	53	5	medications	medication	NOUN
ajst-25617	53	6	that	that	PRON
ajst-25617	53	7	hinder	hinder	VERB
ajst-25617	53	8	tumor	tumor	NOUN
ajst-25617	53	9	cells	cell	NOUN
ajst-25617	53	10	from	from	ADP
ajst-25617	53	11	evading	evade	VERB
ajst-25617	53	12	t	t	NOUN
ajst-25617	53	13	cell	cell	NOUN
ajst-25617	53	14	assault	assault	NOUN
ajst-25617	53	15	by	by	ADP
ajst-25617	53	16	targeting	target	VERB
ajst-25617	53	17	immune	immune	ADJ
ajst-25617	53	18	checkpoints	checkpoint	NOUN
ajst-25617	53	19	(	(	PUNCT
ajst-25617	53	20	such	such	ADJ
ajst-25617	53	21	as	as	ADP
ajst-25617	53	22	pd-1	pd-1	ADP
ajst-25617	53	23	/	/	SYM
ajst-25617	53	24	pd	pd	NOUN
ajst-25617	53	25	-	-	PUNCT
ajst-25617	53	26	l1	l1	PROPN
ajst-25617	53	27	)	)	PUNCT
ajst-25617	53	28	,	,	PUNCT
ajst-25617	53	29	thus	thus	ADV
ajst-25617	53	30	enabling	enable	VERB
ajst-25617	53	31	the	the	DET
ajst-25617	53	32	anticancer	anticancer	NOUN
ajst-25617	53	33	potential	potential	NOUN
ajst-25617	53	34	of	of	ADP
ajst-25617	53	35	t	t	PROPN
ajst-25617	53	36	cells	cell	NOUN
ajst-25617	53	37	to	to	PART
ajst-25617	53	38	be	be	AUX
ajst-25617	53	39	unleashed	unleash	VERB
ajst-25617	53	40	.	.	PUNCT
ajst-25617	54	1	til	til	ADV
ajst-25617	54	2	therapy	therapy	NOUN
ajst-25617	54	3	:	:	PUNCT
ajst-25617	54	4	utilizing	utilize	VERB
ajst-25617	54	5	the	the	DET
ajst-25617	54	6	patient	patient	NOUN
ajst-25617	54	7	's	's	PART
ajst-25617	54	8	own	own	ADJ
ajst-25617	54	9	tumor	tumor	NOUN
ajst-25617	54	10	-	-	PUNCT
ajst-25617	54	11	infiltrating	infiltrate	VERB
ajst-25617	54	12	lymphocytes	lymphocyte	NOUN
ajst-25617	54	13	(	(	PUNCT
ajst-25617	54	14	tils	til	NOUN
ajst-25617	54	15	)	)	PUNCT
ajst-25617	54	16	,	,	PUNCT
ajst-25617	54	17	which	which	PRON
ajst-25617	54	18	have	have	AUX
ajst-25617	54	19	already	already	ADV
ajst-25617	54	20	demonstrated	demonstrate	VERB
ajst-25617	54	21	the	the	DET
ajst-25617	54	22	ability	ability	NOUN
ajst-25617	54	23	to	to	PART
ajst-25617	54	24	attack	attack	VERB
ajst-25617	54	25	cancer	cancer	NOUN
ajst-25617	54	26	cells	cell	NOUN
ajst-25617	54	27	in	in	ADP
ajst-25617	54	28	vivo	vivo	NOUN
ajst-25617	54	29	,	,	PUNCT
ajst-25617	54	30	they	they	PRON
ajst-25617	54	31	are	be	AUX
ajst-25617	54	32	expanded	expand	VERB
ajst-25617	54	33	in	in	ADP
ajst-25617	54	34	vitro	vitro	X
ajst-25617	54	35	and	and	CCONJ
ajst-25617	54	36	then	then	ADV
ajst-25617	54	37	returned	return	VERB
ajst-25617	54	38	to	to	ADP
ajst-25617	54	39	the	the	DET
ajst-25617	54	40	patient	patient	NOUN
ajst-25617	54	41	to	to	PART
ajst-25617	54	42	enhance	enhance	VERB
ajst-25617	54	43	their	their	PRON
ajst-25617	54	44	anticancer	anticancer	NOUN
ajst-25617	54	45	effect	effect	NOUN
ajst-25617	54	46	.	.	PUNCT
ajst-25617	55	1	cancer	cancer	NOUN
ajst-25617	55	2	vaccines	vaccine	NOUN
ajst-25617	55	3	:	:	PUNCT
ajst-25617	55	4	designed	design	VERB
ajst-25617	55	5	to	to	PART
ajst-25617	55	6	activate	activate	VERB
ajst-25617	55	7	t	t	PROPN
ajst-25617	55	8	cell	cell	NOUN
ajst-25617	55	9	immune	immune	ADJ
ajst-25617	55	10	responses	response	NOUN
ajst-25617	55	11	against	against	ADP
ajst-25617	55	12	specific	specific	ADJ
ajst-25617	55	13	tumor	tumor	NOUN
ajst-25617	55	14	antigens	antigen	NOUN
ajst-25617	55	15	,	,	PUNCT
ajst-25617	55	16	they	they	PRON
ajst-25617	55	17	can	can	AUX
ajst-25617	55	18	be	be	AUX
ajst-25617	55	19	used	use	VERB
ajst-25617	55	20	to	to	PART
ajst-25617	55	21	prevent	prevent	VERB
ajst-25617	55	22	or	or	CCONJ
ajst-25617	55	23	treat	treat	VERB
ajst-25617	55	24	cancer	cancer	NOUN
ajst-25617	55	25	.	.	PUNCT
ajst-25617	56	1	3.4	3.4	NUM
ajst-25617	56	2	.	.	PUNCT
ajst-25617	56	3	main	main	ADJ
ajst-25617	56	4	types	type	NOUN
ajst-25617	56	5	of	of	ADP
ajst-25617	56	6	cellular	cellular	ADJ
ajst-25617	56	7	immunotherapy	immunotherapy	NOUN
ajst-25617	56	8	car	car	NOUN
ajst-25617	56	9	-	-	PUNCT
ajst-25617	56	10	t	t	NOUN
ajst-25617	56	11	cell	cell	NOUN
ajst-25617	56	12	therapy	therapy	NOUN
ajst-25617	56	13	:	:	PUNCT
ajst-25617	56	14	in	in	ADP
ajst-25617	56	15	hematological	hematological	ADJ
ajst-25617	56	16	malignancies	malignancy	NOUN
ajst-25617	56	17	,	,	PUNCT
ajst-25617	56	18	car	car	NOUN
ajst-25617	56	19	-	-	PUNCT
ajst-25617	56	20	t	t	PROPN
ajst-25617	56	21	is	be	AUX
ajst-25617	56	22	the	the	DET
ajst-25617	56	23	absolute	absolute	ADJ
ajst-25617	56	24	leader	leader	NOUN
ajst-25617	56	25	in	in	ADP
ajst-25617	56	26	cell	cell	NOUN
ajst-25617	56	27	therapy	therapy	NOUN
ajst-25617	56	28	,	,	PUNCT
ajst-25617	56	29	with	with	ADP
ajst-25617	56	30	cd19	cd19	PROPN
ajst-25617	56	31	being	be	AUX
ajst-25617	56	32	the	the	DET
ajst-25617	56	33	primary	primary	ADJ
ajst-25617	56	34	target	target	NOUN
ajst-25617	56	35	,	,	PUNCT
ajst-25617	56	36	followed	follow	VERB
ajst-25617	56	37	by	by	ADP
ajst-25617	56	38	bcma	bcma	PROPN
ajst-25617	56	39	,	,	PUNCT
ajst-25617	56	40	cd20	cd20	PROPN
ajst-25617	56	41	,	,	PUNCT
ajst-25617	56	42	cd22	cd22	PROPN
ajst-25617	56	43	,	,	PUNCT
ajst-25617	56	44	and	and	CCONJ
ajst-25617	56	45	cd123	cd123	PROPN
ajst-25617	56	46	.	.	PUNCT
ajst-25617	57	1	in	in	ADP
ajst-25617	57	2	the	the	DET
ajst-25617	57	3	practice	practice	NOUN
ajst-25617	57	4	of	of	ADP
ajst-25617	57	5	solid	solid	ADJ
ajst-25617	57	6	tumor	tumor	NOUN
ajst-25617	57	7	treatment	treatment	NOUN
ajst-25617	57	8	,	,	PUNCT
ajst-25617	57	9	different	different	ADJ
ajst-25617	57	10	cell	cell	NOUN
ajst-25617	57	11	therapy	therapy	NOUN
ajst-25617	57	12	strategies	strategy	NOUN
ajst-25617	57	13	have	have	AUX
ajst-25617	57	14	been	be	AUX
ajst-25617	57	15	attempted	attempt	VERB
ajst-25617	57	16	,	,	PUNCT
ajst-25617	57	17	but	but	CCONJ
ajst-25617	57	18	none	none	NOUN
ajst-25617	57	19	have	have	AUX
ajst-25617	57	20	achieved	achieve	VERB
ajst-25617	57	21	breakthroughs	breakthrough	NOUN
ajst-25617	57	22	.	.	PUNCT
ajst-25617	58	1	to	to	ADP
ajst-25617	58	2	date	date	NOUN
ajst-25617	58	3	,	,	PUNCT
ajst-25617	58	4	the	the	DET
ajst-25617	58	5	fastest	fast	ADJ
ajst-25617	58	6	and	and	CCONJ
ajst-25617	58	7	most	most	ADV
ajst-25617	58	8	successful	successful	ADJ
ajst-25617	58	9	cell	cell	NOUN
ajst-25617	58	10	therapy	therapy	NOUN
ajst-25617	58	11	from	from	ADP
ajst-25617	58	12	basic	basic	ADJ
ajst-25617	58	13	research	research	NOUN
ajst-25617	58	14	to	to	ADP
ajst-25617	58	15	clinical	clinical	ADJ
ajst-25617	58	16	translation	translation	NOUN
ajst-25617	58	17	is	be	AUX
ajst-25617	58	18	car	car	NOUN
ajst-25617	58	19	-	-	PUNCT
ajst-25617	58	20	t.	t.	NOUN
ajst-25617	58	21	since	since	SCONJ
ajst-25617	58	22	the	the	DET
ajst-25617	58	23	fda	fda	PROPN
ajst-25617	58	24	approved	approve	VERB
ajst-25617	58	25	the	the	DET
ajst-25617	58	26	first	first	ADJ
ajst-25617	58	27	cell	cell	NOUN
ajst-25617	58	28	therapy	therapy	NOUN
ajst-25617	58	29	drug	drug	NOUN
ajst-25617	58	30	in	in	ADP
ajst-25617	58	31	2017	2017	NUM
ajst-25617	58	32	,	,	PUNCT
ajst-25617	58	33	eight	eight	NUM
ajst-25617	58	34	cell	cell	NOUN
ajst-25617	58	35	therapy	therapy	NOUN
ajst-25617	58	36	products	product	NOUN
ajst-25617	58	37	have	have	AUX
ajst-25617	58	38	been	be	AUX
ajst-25617	58	39	launched	launch	VERB
ajst-25617	58	40	successively	successively	ADV
ajst-25617	58	41	,	,	PUNCT
ajst-25617	58	42	as	as	SCONJ
ajst-25617	58	43	shown	show	VERB
ajst-25617	58	44	in	in	ADP
ajst-25617	58	45	table	table	NOUN
ajst-25617	58	46	1	1	NUM
ajst-25617	58	47	.	.	PUNCT
ajst-25617	59	1	among	among	ADP
ajst-25617	59	2	them	they	PRON
ajst-25617	59	3	,	,	PUNCT
ajst-25617	59	4	three	three	NUM
ajst-25617	59	5	are	be	AUX
ajst-25617	59	6	products	product	NOUN
ajst-25617	59	7	from	from	ADP
ajst-25617	59	8	chinese	chinese	ADJ
ajst-25617	59	9	companies	company	NOUN
ajst-25617	59	10	,	,	PUNCT
ajst-25617	59	11	namely	namely	ADV
ajst-25617	59	12	axicabtagene	axicabtagene	VERB
ajst-25617	59	13	ciloleucel	ciloleucel	PROPN
ajst-25617	59	14	,	,	PUNCT
ajst-25617	59	15	relma	relma	PROPN
ajst-25617	59	16	-	-	PUNCT
ajst-25617	59	17	cel	cel	PROPN
ajst-25617	59	18	targeting	target	VERB
ajst-25617	59	19	cd19	cd19	PROPN
ajst-25617	59	20	and	and	CCONJ
ajst-25617	59	21	ciltacabtagene	ciltacabtagene	PROPN
ajst-25617	59	22	autoleucel	autoleucel	AUX
ajst-25617	59	23	targeting	target	VERB
ajst-25617	59	24	b	b	PRON
ajst-25617	59	25	cell	cell	NOUN
ajst-25617	59	26	maturation	maturation	NOUN
ajst-25617	59	27	antigen	antigen	NOUN
ajst-25617	59	28	(	(	PUNCT
ajst-25617	59	29	bcma	bcma	PROPN
ajst-25617	59	30	)	)	PUNCT
ajst-25617	59	31	.	.	PUNCT
ajst-25617	60	1	china	china	PROPN
ajst-25617	60	2	is	be	AUX
ajst-25617	60	3	developing	develop	VERB
ajst-25617	60	4	rapidly	rapidly	ADV
ajst-25617	60	5	in	in	ADP
ajst-25617	60	6	this	this	DET
ajst-25617	60	7	field	field	NOUN
ajst-25617	60	8	.	.	PUNCT
ajst-25617	61	1	since	since	SCONJ
ajst-25617	61	2	2016	2016	NUM
ajst-25617	61	3	,	,	PUNCT
ajst-25617	61	4	more	more	ADJ
ajst-25617	61	5	than	than	ADP
ajst-25617	61	6	300	300	NUM
ajst-25617	61	7	cell	cell	NOUN
ajst-25617	61	8	therapy	therapy	NOUN
ajst-25617	61	9	products	product	NOUN
ajst-25617	61	10	have	have	AUX
ajst-25617	61	11	been	be	AUX
ajst-25617	61	12	in	in	ADP
ajst-25617	61	13	clinical	clinical	ADJ
ajst-25617	61	14	research	research	NOUN
ajst-25617	61	15	,	,	PUNCT
ajst-25617	61	16	and	and	CCONJ
ajst-25617	61	17	many	many	ADJ
ajst-25617	61	18	are	be	AUX
ajst-25617	61	19	still	still	ADV
ajst-25617	61	20	in	in	ADP
ajst-25617	61	21	preclinical	preclinical	ADJ
ajst-25617	61	22	research	research	NOUN
ajst-25617	61	23	stages	stage	NOUN
ajst-25617	61	24	.	.	PUNCT
ajst-25617	62	1	among	among	ADP
ajst-25617	62	2	the	the	DET
ajst-25617	62	3	three	three	NUM
ajst-25617	62	4	products	product	NOUN
ajst-25617	62	5	currently	currently	ADV
ajst-25617	62	6	listed	list	VERB
ajst-25617	62	7	in	in	ADP
ajst-25617	62	8	china	china	PROPN
ajst-25617	62	9	,	,	PUNCT
ajst-25617	62	10	ciltacabtagene	ciltacabtagene	PROPN
ajst-25617	62	11	autoleucel	autoleucel	PROPN
ajst-25617	62	12	,	,	PUNCT
ajst-25617	62	13	a	a	DET
ajst-25617	62	14	car	car	NOUN
ajst-25617	62	15	-	-	PUNCT
ajst-25617	62	16	t	t	NOUN
ajst-25617	62	17	drug	drug	NOUN
ajst-25617	62	18	therapy	therapy	NOUN
ajst-25617	62	19	targeting	target	VERB
ajst-25617	62	20	the	the	DET
ajst-25617	62	21	bcma	bcma	PROPN
ajst-25617	62	22	target	target	NOUN
ajst-25617	62	23	,	,	PUNCT
ajst-25617	62	24	is	be	AUX
ajst-25617	62	25	completely	completely	ADV
ajst-25617	62	26	independently	independently	ADV
ajst-25617	62	27	developed	develop	VERB
ajst-25617	62	28	by	by	ADP
ajst-25617	62	29	china	china	PROPN
ajst-25617	62	30	.	.	PUNCT
ajst-25617	63	1	public	public	ADJ
ajst-25617	63	2	data	datum	NOUN
ajst-25617	63	3	shows	show	VERB
ajst-25617	63	4	that	that	SCONJ
ajst-25617	63	5	it	it	PRON
ajst-25617	63	6	has	have	VERB
ajst-25617	63	7	significant	significant	ADJ
ajst-25617	63	8	efficacy	efficacy	NOUN
ajst-25617	63	9	,	,	PUNCT
ajst-25617	63	10	with	with	ADP
ajst-25617	63	11	an	an	DET
ajst-25617	63	12	objective	objective	ADJ
ajst-25617	63	13	response	response	NOUN
ajst-25617	63	14	rate	rate	NOUN
ajst-25617	63	15	of	of	ADP
ajst-25617	63	16	up	up	ADP
ajst-25617	63	17	to	to	PART
ajst-25617	63	18	97.9	97.9	NUM
ajst-25617	63	19	%	%	NOUN
ajst-25617	63	20	in	in	ADP
ajst-25617	63	21	the	the	DET
ajst-25617	63	22	treatment	treatment	NOUN
ajst-25617	63	23	of	of	ADP
ajst-25617	63	24	relapsed	relapse	VERB
ajst-25617	63	25	/	/	SYM
ajst-25617	63	26	refractory	refractory	NOUN
ajst-25617	63	27	multiple	multiple	ADJ
ajst-25617	63	28	myeloma	myeloma	NOUN
ajst-25617	63	29	,	,	PUNCT
ajst-25617	63	30	including	include	VERB
ajst-25617	63	31	a	a	DET
ajst-25617	63	32	stringent	stringent	ADJ
ajst-25617	63	33	complete	complete	ADJ
ajst-25617	63	34	response	response	NOUN
ajst-25617	63	35	rate	rate	NOUN
ajst-25617	63	36	of	of	ADP
ajst-25617	63	37	82.5	82.5	NUM
ajst-25617	63	38	%	%	NOUN
ajst-25617	63	39	,	,	PUNCT
ajst-25617	63	40	and	and	CCONJ
ajst-25617	63	41	controllable	controllable	ADJ
ajst-25617	63	42	safety	safety	NOUN
ajst-25617	63	43	figure	figure	NOUN
ajst-25617	63	44	1	1	NUM
ajst-25617	63	45	.	.	X
ajst-25617	63	46	eight	eight	NUM
ajst-25617	63	47	globally	globally	ADV
ajst-25617	63	48	marketed	market	VERB
ajst-25617	63	49	cancer	cancer	NOUN
ajst-25617	63	50	cell	cell	NOUN
ajst-25617	63	51	immunotherapy	immunotherapy	NOUN
ajst-25617	63	52	products	product	NOUN
ajst-25617	63	53	193	193	NUM
ajst-25617	63	54	tcr	tcr	PROPN
ajst-25617	63	55	-	-	PUNCT
ajst-25617	63	56	t	t	PROPN
ajst-25617	63	57	cell	cell	NOUN
ajst-25617	63	58	therapy	therapy	NOUN
ajst-25617	63	59	:	:	PUNCT
ajst-25617	63	60	tcr	tcr	PROPN
ajst-25617	63	61	-	-	PUNCT
ajst-25617	63	62	t	t	PROPN
ajst-25617	63	63	cells	cell	NOUN
ajst-25617	63	64	recognize	recognize	VERB
ajst-25617	63	65	tumorspecific	tumorspecific	ADJ
ajst-25617	63	66	antigens	antigen	NOUN
ajst-25617	63	67	presented	present	VERB
ajst-25617	63	68	by	by	ADP
ajst-25617	63	69	major	major	ADJ
ajst-25617	63	70	histocompatibility	histocompatibility	NOUN
ajst-25617	63	71	complex	complex	NOUN
ajst-25617	63	72	(	(	PUNCT
ajst-25617	63	73	mhc	mhc	NOUN
ajst-25617	63	74	)	)	PUNCT
ajst-25617	63	75	molecules	molecule	NOUN
ajst-25617	63	76	through	through	ADP
ajst-25617	63	77	their	their	PRON
ajst-25617	63	78	tcrs	tcrs	NOUN
ajst-25617	63	79	on	on	ADP
ajst-25617	63	80	the	the	DET
ajst-25617	63	81	cell	cell	NOUN
ajst-25617	63	82	surface	surface	NOUN
ajst-25617	63	83	.	.	PUNCT
ajst-25617	64	1	these	these	DET
ajst-25617	64	2	antigens	antigen	NOUN
ajst-25617	64	3	can	can	AUX
ajst-25617	64	4	be	be	AUX
ajst-25617	64	5	neoantigens	neoantigen	NOUN
ajst-25617	64	6	produced	produce	VERB
ajst-25617	64	7	by	by	ADP
ajst-25617	64	8	tumor	tumor	NOUN
ajst-25617	64	9	cells	cell	NOUN
ajst-25617	64	10	due	due	ADJ
ajst-25617	64	11	to	to	ADP
ajst-25617	64	12	genetic	genetic	ADJ
ajst-25617	64	13	mutations	mutation	NOUN
ajst-25617	64	14	,	,	PUNCT
ajst-25617	64	15	viral	viral	ADJ
ajst-25617	64	16	infections	infection	NOUN
ajst-25617	64	17	,	,	PUNCT
ajst-25617	64	18	or	or	CCONJ
ajst-25617	64	19	other	other	ADJ
ajst-25617	64	20	mechanisms	mechanism	NOUN
ajst-25617	64	21	,	,	PUNCT
ajst-25617	64	22	or	or	CCONJ
ajst-25617	64	23	they	they	PRON
ajst-25617	64	24	can	can	AUX
ajst-25617	64	25	be	be	AUX
ajst-25617	64	26	protein	protein	NOUN
ajst-25617	64	27	fragments	fragment	NOUN
ajst-25617	64	28	abnormally	abnormally	ADV
ajst-25617	64	29	expressed	express	VERB
ajst-25617	64	30	by	by	ADP
ajst-25617	64	31	tumor	tumor	NOUN
ajst-25617	64	32	cells	cell	NOUN
ajst-25617	64	33	.	.	PUNCT
ajst-25617	65	1	the	the	DET
ajst-25617	65	2	tcrs	tcrs	NOUN
ajst-25617	65	3	of	of	ADP
ajst-25617	65	4	tcr	tcr	PROPN
ajst-25617	65	5	-	-	PUNCT
ajst-25617	65	6	t	t	PROPN
ajst-25617	65	7	cells	cell	NOUN
ajst-25617	65	8	bind	bind	VERB
ajst-25617	65	9	to	to	ADP
ajst-25617	65	10	antigen	antigen	ADJ
ajst-25617	65	11	peptide	peptide	ADJ
ajst-25617	65	12	fragments	fragment	NOUN
ajst-25617	65	13	on	on	ADP
ajst-25617	65	14	mhc	mhc	PROPN
ajst-25617	65	15	molecules	molecule	NOUN
ajst-25617	65	16	,	,	PUNCT
ajst-25617	65	17	activating	activate	VERB
ajst-25617	65	18	the	the	DET
ajst-25617	65	19	t	t	NOUN
ajst-25617	65	20	cells	cell	NOUN
ajst-25617	65	21	and	and	CCONJ
ajst-25617	65	22	subsequently	subsequently	ADV
ajst-25617	65	23	killing	kill	VERB
ajst-25617	65	24	tumor	tumor	NOUN
ajst-25617	65	25	cells	cell	NOUN
ajst-25617	65	26	or	or	CCONJ
ajst-25617	65	27	activating	activate	VERB
ajst-25617	65	28	other	other	ADJ
ajst-25617	65	29	immune	immune	ADJ
ajst-25617	65	30	cells	cell	NOUN
ajst-25617	65	31	through	through	ADP
ajst-25617	65	32	cytokine	cytokine	ADJ
ajst-25617	65	33	secretion	secretion	NOUN
ajst-25617	65	34	to	to	PART
ajst-25617	65	35	participate	participate	VERB
ajst-25617	65	36	in	in	ADP
ajst-25617	65	37	the	the	DET
ajst-25617	65	38	antitumor	antitumor	PROPN
ajst-25617	65	39	response	response	NOUN
ajst-25617	65	40	.	.	PUNCT
ajst-25617	66	1	compared	compare	VERB
ajst-25617	66	2	to	to	ADP
ajst-25617	66	3	car	car	NOUN
ajst-25617	66	4	-	-	PUNCT
ajst-25617	66	5	t	t	NOUN
ajst-25617	66	6	cell	cell	NOUN
ajst-25617	66	7	therapy	therapy	NOUN
ajst-25617	66	8	,	,	PUNCT
ajst-25617	66	9	tcrt	tcrt	NOUN
ajst-25617	66	10	cell	cell	NOUN
ajst-25617	66	11	therapy	therapy	NOUN
ajst-25617	66	12	has	have	VERB
ajst-25617	66	13	advantages	advantage	NOUN
ajst-25617	66	14	in	in	ADP
ajst-25617	66	15	recognizing	recognize	VERB
ajst-25617	66	16	neoantigens	neoantigen	NOUN
ajst-25617	66	17	within	within	ADP
ajst-25617	66	18	tumors	tumor	NOUN
ajst-25617	66	19	and	and	CCONJ
ajst-25617	66	20	those	those	PRON
ajst-25617	66	21	produced	produce	VERB
ajst-25617	66	22	by	by	ADP
ajst-25617	66	23	mutations	mutation	NOUN
ajst-25617	66	24	,	,	PUNCT
ajst-25617	66	25	especially	especially	ADV
ajst-25617	66	26	showing	show	VERB
ajst-25617	66	27	potential	potential	NOUN
ajst-25617	66	28	in	in	ADP
ajst-25617	66	29	the	the	DET
ajst-25617	66	30	treatment	treatment	NOUN
ajst-25617	66	31	of	of	ADP
ajst-25617	66	32	solid	solid	ADJ
ajst-25617	66	33	tumors	tumor	NOUN
ajst-25617	66	34	.	.	PUNCT
ajst-25617	67	1	however	however	ADV
ajst-25617	67	2	,	,	PUNCT
ajst-25617	67	3	its	its	PRON
ajst-25617	67	4	application	application	NOUN
ajst-25617	67	5	is	be	AUX
ajst-25617	67	6	limited	limit	VERB
ajst-25617	67	7	by	by	ADP
ajst-25617	67	8	mhc	mhc	PROPN
ajst-25617	67	9	matching	matching	NOUN
ajst-25617	67	10	and	and	CCONJ
ajst-25617	67	11	potential	potential	ADJ
ajst-25617	67	12	offtarget	offtarget	NOUN
ajst-25617	67	13	effects	effect	NOUN
ajst-25617	67	14	.	.	PUNCT
ajst-25617	68	1	inhibitors	inhibitor	NOUN
ajst-25617	68	2	of	of	ADP
ajst-25617	68	3	immune	immune	ADJ
ajst-25617	68	4	checkpoints	checkpoint	NOUN
ajst-25617	68	5	:	:	PUNCT
ajst-25617	68	6	immune	immune	ADJ
ajst-25617	68	7	checkpoints	checkpoint	NOUN
ajst-25617	68	8	are	be	AUX
ajst-25617	68	9	regulatory	regulatory	ADJ
ajst-25617	68	10	mechanisms	mechanism	NOUN
ajst-25617	68	11	that	that	PRON
ajst-25617	68	12	play	play	VERB
ajst-25617	68	13	a	a	DET
ajst-25617	68	14	vital	vital	ADJ
ajst-25617	68	15	role	role	NOUN
ajst-25617	68	16	in	in	ADP
ajst-25617	68	17	maintaining	maintain	VERB
ajst-25617	68	18	the	the	DET
ajst-25617	68	19	balance	balance	NOUN
ajst-25617	68	20	of	of	ADP
ajst-25617	68	21	the	the	DET
ajst-25617	68	22	immune	immune	ADJ
ajst-25617	68	23	system	system	NOUN
ajst-25617	68	24	.	.	PUNCT
ajst-25617	69	1	consequently	consequently	ADV
ajst-25617	69	2	,	,	PUNCT
ajst-25617	69	3	drugs	drug	NOUN
ajst-25617	69	4	known	know	VERB
ajst-25617	69	5	as	as	ADP
ajst-25617	69	6	immune	immune	ADJ
ajst-25617	69	7	checkpoint	checkpoint	NOUN
ajst-25617	69	8	inhibitors	inhibitor	NOUN
ajst-25617	69	9	can	can	AUX
ajst-25617	69	10	alleviate	alleviate	VERB
ajst-25617	69	11	the	the	DET
ajst-25617	69	12	suppression	suppression	NOUN
ajst-25617	69	13	caused	cause	VERB
ajst-25617	69	14	by	by	ADP
ajst-25617	69	15	tumors	tumor	NOUN
ajst-25617	69	16	on	on	ADP
ajst-25617	69	17	the	the	DET
ajst-25617	69	18	immune	immune	ADJ
ajst-25617	69	19	system	system	NOUN
ajst-25617	69	20	.	.	PUNCT
ajst-25617	70	1	by	by	ADP
ajst-25617	70	2	blocking	block	VERB
ajst-25617	70	3	interactions	interaction	NOUN
ajst-25617	70	4	between	between	ADP
ajst-25617	70	5	pd-1	pd-1	NOUN
ajst-25617	70	6	/	/	SYM
ajst-25617	70	7	pd	pd	NOUN
ajst-25617	70	8	-	-	PROPN
ajst-25617	70	9	l1	l1	PROPN
ajst-25617	70	10	and	and	CCONJ
ajst-25617	70	11	ctla-4	ctla-4	NOUN
ajst-25617	70	12	/	/	SYM
ajst-25617	70	13	b7	b7	PROPN
ajst-25617	70	14	,	,	PUNCT
ajst-25617	70	15	pd-1	pd-1	VERB
ajst-25617	70	16	inhibitors	inhibitor	NOUN
ajst-25617	70	17	(	(	PUNCT
ajst-25617	70	18	such	such	ADJ
ajst-25617	70	19	as	as	ADP
ajst-25617	70	20	pembrolizumab	pembrolizumab	NOUN
ajst-25617	70	21	and	and	CCONJ
ajst-25617	70	22	nivolumab	nivolumab	NOUN
ajst-25617	70	23	)	)	PUNCT
ajst-25617	70	24	and	and	CCONJ
ajst-25617	70	25	ctla-4	ctla-4	NOUN
ajst-25617	70	26	inhibitors	inhibitor	NOUN
ajst-25617	70	27	(	(	PUNCT
ajst-25617	70	28	such	such	ADJ
ajst-25617	70	29	as	as	ADP
ajst-25617	70	30	ipilimumab	ipilimumab	ADJ
ajst-25617	70	31	)	)	PUNCT
ajst-25617	70	32	disrupt	disrupt	VERB
ajst-25617	70	33	inhibitory	inhibitory	ADJ
ajst-25617	70	34	signals	signal	NOUN
ajst-25617	70	35	,	,	PUNCT
ajst-25617	70	36	enabling	enable	VERB
ajst-25617	70	37	t	t	NOUN
ajst-25617	70	38	cells	cell	NOUN
ajst-25617	70	39	to	to	PART
ajst-25617	70	40	regain	regain	VERB
ajst-25617	70	41	their	their	PRON
ajst-25617	70	42	functionality	functionality	NOUN
ajst-25617	70	43	and	and	CCONJ
ajst-25617	70	44	enhance	enhance	VERB
ajst-25617	70	45	their	their	PRON
ajst-25617	70	46	ability	ability	NOUN
ajst-25617	70	47	to	to	PART
ajst-25617	70	48	identify	identify	VERB
ajst-25617	70	49	and	and	CCONJ
ajst-25617	70	50	attack	attack	VERB
ajst-25617	70	51	tumor	tumor	NOUN
ajst-25617	70	52	cells	cell	NOUN
ajst-25617	70	53	.	.	PUNCT
ajst-25617	71	1	these	these	DET
ajst-25617	71	2	inhibitors	inhibitor	NOUN
ajst-25617	71	3	have	have	AUX
ajst-25617	71	4	demonstrated	demonstrate	VERB
ajst-25617	71	5	significant	significant	ADJ
ajst-25617	71	6	clinical	clinical	ADJ
ajst-25617	71	7	efficacy	efficacy	NOUN
ajst-25617	71	8	in	in	ADP
ajst-25617	71	9	treating	treat	VERB
ajst-25617	71	10	various	various	ADJ
ajst-25617	71	11	cancers	cancer	NOUN
ajst-25617	71	12	like	like	ADP
ajst-25617	71	13	melanoma	melanoma	NOUN
ajst-25617	71	14	,	,	PUNCT
ajst-25617	71	15	non	non	ADJ
ajst-25617	71	16	-	-	ADJ
ajst-25617	71	17	small	small	ADJ
ajst-25617	71	18	cell	cell	NOUN
ajst-25617	71	19	lung	lung	NOUN
ajst-25617	71	20	cancer	cancer	NOUN
ajst-25617	71	21	,	,	PUNCT
ajst-25617	71	22	renal	renal	ADJ
ajst-25617	71	23	cell	cell	NOUN
ajst-25617	71	24	carcinoma	carcinoma	NOUN
ajst-25617	71	25	,	,	PUNCT
ajst-25617	71	26	among	among	ADP
ajst-25617	71	27	others	other	NOUN
ajst-25617	71	28	.	.	PUNCT
ajst-25617	72	1	however	however	ADV
ajst-25617	72	2	,	,	PUNCT
ajst-25617	72	3	it	it	PRON
ajst-25617	72	4	is	be	AUX
ajst-25617	72	5	important	important	ADJ
ajst-25617	72	6	to	to	PART
ajst-25617	72	7	note	note	VERB
ajst-25617	72	8	that	that	SCONJ
ajst-25617	72	9	they	they	PRON
ajst-25617	72	10	may	may	AUX
ajst-25617	72	11	also	also	ADV
ajst-25617	72	12	lead	lead	VERB
ajst-25617	72	13	to	to	ADP
ajst-25617	72	14	immune	immune	NOUN
ajst-25617	72	15	-	-	PUNCT
ajst-25617	72	16	related	relate	VERB
ajst-25617	72	17	side	side	NOUN
ajst-25617	72	18	effects	effect	NOUN
ajst-25617	72	19	such	such	ADJ
ajst-25617	72	20	as	as	ADP
ajst-25617	72	21	autoimmune	autoimmune	ADJ
ajst-25617	72	22	diseases	disease	NOUN
ajst-25617	72	23	;	;	PUNCT
ajst-25617	72	24	hence	hence	ADV
ajst-25617	72	25	careful	careful	ADJ
ajst-25617	72	26	monitoring	monitoring	NOUN
ajst-25617	72	27	and	and	CCONJ
ajst-25617	72	28	management	management	NOUN
ajst-25617	72	29	are	be	AUX
ajst-25617	72	30	necessary	necessary	ADJ
ajst-25617	72	31	during	during	ADP
ajst-25617	72	32	their	their	PRON
ajst-25617	72	33	usage	usage	NOUN
ajst-25617	72	34	.	.	PUNCT
ajst-25617	73	1	tumor	tumor	NOUN
ajst-25617	73	2	infiltrating	infiltrate	VERB
ajst-25617	73	3	lymphocyte	lymphocyte	ADJ
ajst-25617	73	4	therapy	therapy	NOUN
ajst-25617	73	5	and	and	CCONJ
ajst-25617	73	6	cancer	cancer	NOUN
ajst-25617	73	7	vaccines	vaccine	NOUN
ajst-25617	73	8	:	:	PUNCT
ajst-25617	74	1	til	til	ADV
ajst-25617	74	2	therapy	therapy	NOUN
ajst-25617	74	3	and	and	CCONJ
ajst-25617	74	4	cancer	cancer	NOUN
ajst-25617	74	5	vaccines	vaccine	NOUN
ajst-25617	74	6	are	be	AUX
ajst-25617	74	7	two	two	NUM
ajst-25617	74	8	different	different	ADJ
ajst-25617	74	9	types	type	NOUN
ajst-25617	74	10	of	of	ADP
ajst-25617	74	11	immunotherapy	immunotherapy	NOUN
ajst-25617	74	12	,	,	PUNCT
ajst-25617	74	13	both	both	PRON
ajst-25617	74	14	of	of	ADP
ajst-25617	74	15	which	which	PRON
ajst-25617	74	16	aim	aim	VERB
ajst-25617	74	17	to	to	PART
ajst-25617	74	18	harness	harness	VERB
ajst-25617	74	19	the	the	DET
ajst-25617	74	20	patient	patient	NOUN
ajst-25617	74	21	's	's	PART
ajst-25617	74	22	own	own	ADJ
ajst-25617	74	23	immune	immune	ADJ
ajst-25617	74	24	system	system	NOUN
ajst-25617	74	25	to	to	PART
ajst-25617	74	26	fight	fight	VERB
ajst-25617	74	27	cancer	cancer	NOUN
ajst-25617	74	28	.	.	PUNCT
ajst-25617	75	1	til	til	SCONJ
ajst-25617	75	2	therapy	therapy	NOUN
ajst-25617	75	3	requires	require	VERB
ajst-25617	75	4	the	the	DET
ajst-25617	75	5	extraction	extraction	NOUN
ajst-25617	75	6	of	of	ADP
ajst-25617	75	7	tumor	tumor	NOUN
ajst-25617	75	8	infiltrating	infiltrate	VERB
ajst-25617	75	9	lymphocytes	lymphocyte	NOUN
ajst-25617	75	10	(	(	PUNCT
ajst-25617	75	11	tils	til	NOUN
ajst-25617	75	12	)	)	PUNCT
ajst-25617	75	13	from	from	ADP
ajst-25617	75	14	the	the	DET
ajst-25617	75	15	patient	patient	NOUN
ajst-25617	75	16	's	's	PART
ajst-25617	75	17	tumor	tumor	NOUN
ajst-25617	75	18	tissue	tissue	NOUN
ajst-25617	75	19	.	.	PUNCT
ajst-25617	76	1	these	these	DET
ajst-25617	76	2	cells	cell	NOUN
ajst-25617	76	3	are	be	AUX
ajst-25617	76	4	naturally	naturally	ADV
ajst-25617	76	5	present	present	ADJ
ajst-25617	76	6	in	in	ADP
ajst-25617	76	7	the	the	DET
ajst-25617	76	8	tumor	tumor	NOUN
ajst-25617	76	9	microenvironment	microenvironment	NOUN
ajst-25617	76	10	and	and	CCONJ
ajst-25617	76	11	have	have	VERB
ajst-25617	76	12	the	the	DET
ajst-25617	76	13	ability	ability	NOUN
ajst-25617	76	14	to	to	PART
ajst-25617	76	15	recognize	recognize	VERB
ajst-25617	76	16	and	and	CCONJ
ajst-25617	76	17	attack	attack	VERB
ajst-25617	76	18	cancer	cancer	NOUN
ajst-25617	76	19	cells	cell	NOUN
ajst-25617	76	20	.	.	PUNCT
ajst-25617	77	1	in	in	ADP
ajst-25617	77	2	the	the	DET
ajst-25617	77	3	lab	lab	NOUN
ajst-25617	77	4	,	,	PUNCT
ajst-25617	77	5	these	these	DET
ajst-25617	77	6	tils	til	NOUN
ajst-25617	77	7	are	be	AUX
ajst-25617	77	8	augmented	augment	VERB
ajst-25617	77	9	to	to	PART
ajst-25617	77	10	increase	increase	VERB
ajst-25617	77	11	their	their	PRON
ajst-25617	77	12	numbers	number	NOUN
ajst-25617	77	13	and	and	CCONJ
ajst-25617	77	14	then	then	ADV
ajst-25617	77	15	reinjected	reinjecte	VERB
ajst-25617	77	16	into	into	ADP
ajst-25617	77	17	the	the	DET
ajst-25617	77	18	patient	patient	NOUN
ajst-25617	77	19	to	to	PART
ajst-25617	77	20	strengthen	strengthen	VERB
ajst-25617	77	21	the	the	DET
ajst-25617	77	22	immune	immune	ADJ
ajst-25617	77	23	system	system	NOUN
ajst-25617	77	24	's	's	PART
ajst-25617	77	25	attack	attack	NOUN
ajst-25617	77	26	on	on	ADP
ajst-25617	77	27	the	the	DET
ajst-25617	77	28	tumor	tumor	NOUN
ajst-25617	77	29	.	.	PUNCT
ajst-25617	78	1	til	til	SCONJ
ajst-25617	78	2	therapy	therapy	NOUN
ajst-25617	78	3	has	have	AUX
ajst-25617	78	4	shown	show	VERB
ajst-25617	78	5	some	some	DET
ajst-25617	78	6	success	success	NOUN
ajst-25617	78	7	in	in	ADP
ajst-25617	78	8	treating	treat	VERB
ajst-25617	78	9	certain	certain	ADJ
ajst-25617	78	10	types	type	NOUN
ajst-25617	78	11	of	of	ADP
ajst-25617	78	12	solid	solid	ADJ
ajst-25617	78	13	tumors	tumor	NOUN
ajst-25617	78	14	,	,	PUNCT
ajst-25617	78	15	particularly	particularly	ADV
ajst-25617	78	16	advanced	advanced	ADJ
ajst-25617	78	17	melanoma	melanoma	NOUN
ajst-25617	78	18	.	.	PUNCT
ajst-25617	79	1	for	for	ADP
ajst-25617	79	2	example	example	NOUN
ajst-25617	79	3	,	,	PUNCT
ajst-25617	79	4	lifileucel	lifileucel	PROPN
ajst-25617	79	5	,	,	PUNCT
ajst-25617	79	6	a	a	DET
ajst-25617	79	7	ti	ti	NOUN
ajst-25617	79	8	-	-	PUNCT
ajst-25617	79	9	based	base	VERB
ajst-25617	79	10	approach	approach	NOUN
ajst-25617	79	11	,	,	PUNCT
ajst-25617	79	12	has	have	AUX
ajst-25617	79	13	been	be	AUX
ajst-25617	79	14	approved	approve	VERB
ajst-25617	79	15	by	by	ADP
ajst-25617	79	16	the	the	DET
ajst-25617	79	17	u.s	u.s	PROPN
ajst-25617	79	18	.	.	PROPN
ajst-25617	79	19	food	food	PROPN
ajst-25617	79	20	and	and	CCONJ
ajst-25617	79	21	drug	drug	NOUN
ajst-25617	79	22	administration	administration	NOUN
ajst-25617	79	23	for	for	ADP
ajst-25617	79	24	some	some	DET
ajst-25617	79	25	types	type	NOUN
ajst-25617	79	26	of	of	ADP
ajst-25617	79	27	advanced	advanced	ADJ
ajst-25617	79	28	melanoma	melanoma	NOUN
ajst-25617	79	29	.	.	PUNCT
ajst-25617	80	1	in	in	ADP
ajst-25617	80	2	addition	addition	NOUN
ajst-25617	80	3	,	,	PUNCT
ajst-25617	80	4	til	til	SCONJ
ajst-25617	80	5	therapy	therapy	NOUN
ajst-25617	80	6	is	be	AUX
ajst-25617	80	7	also	also	ADV
ajst-25617	80	8	undergoing	undergo	VERB
ajst-25617	80	9	clinical	clinical	ADJ
ajst-25617	80	10	trials	trial	NOUN
ajst-25617	80	11	in	in	ADP
ajst-25617	80	12	other	other	ADJ
ajst-25617	80	13	types	type	NOUN
ajst-25617	80	14	of	of	ADP
ajst-25617	80	15	cancer	cancer	NOUN
ajst-25617	80	16	,	,	PUNCT
ajst-25617	80	17	such	such	ADJ
ajst-25617	80	18	as	as	ADP
ajst-25617	80	19	lung	lung	NOUN
ajst-25617	80	20	and	and	CCONJ
ajst-25617	80	21	pancreatic	pancreatic	ADJ
ajst-25617	80	22	cancer	cancer	NOUN
ajst-25617	80	23	,	,	PUNCT
ajst-25617	80	24	showing	show	VERB
ajst-25617	80	25	potential	potential	NOUN
ajst-25617	80	26	for	for	ADP
ajst-25617	80	27	treatment	treatment	NOUN
ajst-25617	80	28	.	.	PUNCT
ajst-25617	81	1	cancer	cancer	NOUN
ajst-25617	81	2	vaccines	vaccine	NOUN
ajst-25617	81	3	work	work	VERB
ajst-25617	81	4	by	by	ADP
ajst-25617	81	5	introducing	introduce	VERB
ajst-25617	81	6	specific	specific	ADJ
ajst-25617	81	7	tumor	tumor	NOUN
ajst-25617	81	8	antigens	antigen	NOUN
ajst-25617	81	9	or	or	CCONJ
ajst-25617	81	10	related	relate	VERB
ajst-25617	81	11	molecules	molecule	NOUN
ajst-25617	81	12	to	to	PART
ajst-25617	81	13	activate	activate	VERB
ajst-25617	81	14	t	t	NOUN
ajst-25617	81	15	cells	cell	NOUN
ajst-25617	81	16	and	and	CCONJ
ajst-25617	81	17	b	b	NOUN
ajst-25617	81	18	cells	cell	NOUN
ajst-25617	81	19	in	in	ADP
ajst-25617	81	20	the	the	DET
ajst-25617	81	21	patient	patient	NOUN
ajst-25617	81	22	's	's	PART
ajst-25617	81	23	immune	immune	ADJ
ajst-25617	81	24	system	system	NOUN
ajst-25617	81	25	,	,	PUNCT
ajst-25617	81	26	triggering	trigger	VERB
ajst-25617	81	27	an	an	DET
ajst-25617	81	28	immune	immune	ADJ
ajst-25617	81	29	response	response	NOUN
ajst-25617	81	30	against	against	ADP
ajst-25617	81	31	tumor	tumor	NOUN
ajst-25617	81	32	cells	cell	NOUN
ajst-25617	81	33	.	.	PUNCT
ajst-25617	82	1	these	these	DET
ajst-25617	82	2	antigens	antigen	NOUN
ajst-25617	82	3	can	can	AUX
ajst-25617	82	4	be	be	AUX
ajst-25617	82	5	proteins	protein	NOUN
ajst-25617	82	6	expressed	express	VERB
ajst-25617	82	7	on	on	ADP
ajst-25617	82	8	the	the	DET
ajst-25617	82	9	surface	surface	NOUN
ajst-25617	82	10	of	of	ADP
ajst-25617	82	11	tumor	tumor	NOUN
ajst-25617	82	12	cells	cell	NOUN
ajst-25617	82	13	,	,	PUNCT
ajst-25617	82	14	neoantigens	neoantigen	NOUN
ajst-25617	82	15	produced	produce	VERB
ajst-25617	82	16	by	by	ADP
ajst-25617	82	17	tumor	tumor	NOUN
ajst-25617	82	18	cell	cell	NOUN
ajst-25617	82	19	mutations	mutation	NOUN
ajst-25617	82	20	,	,	PUNCT
ajst-25617	82	21	or	or	CCONJ
ajst-25617	82	22	tumor	tumor	NOUN
ajst-25617	82	23	-	-	PUNCT
ajst-25617	82	24	related	relate	VERB
ajst-25617	82	25	molecules	molecule	NOUN
ajst-25617	82	26	presented	present	VERB
ajst-25617	82	27	in	in	ADP
ajst-25617	82	28	other	other	ADJ
ajst-25617	82	29	ways	way	NOUN
ajst-25617	82	30	.	.	PUNCT
ajst-25617	83	1	clinical	clinical	ADJ
ajst-25617	83	2	research	research	NOUN
ajst-25617	83	3	on	on	ADP
ajst-25617	83	4	cancer	cancer	NOUN
ajst-25617	83	5	vaccines	vaccine	NOUN
ajst-25617	83	6	is	be	AUX
ajst-25617	83	7	more	more	ADV
ajst-25617	83	8	extensive	extensive	ADJ
ajst-25617	83	9	,	,	PUNCT
ajst-25617	83	10	covering	cover	VERB
ajst-25617	83	11	various	various	ADJ
ajst-25617	83	12	types	type	NOUN
ajst-25617	83	13	of	of	ADP
ajst-25617	83	14	cancer	cancer	NOUN
ajst-25617	83	15	and	and	CCONJ
ajst-25617	83	16	different	different	ADJ
ajst-25617	83	17	vaccine	vaccine	NOUN
ajst-25617	83	18	strategies	strategy	NOUN
ajst-25617	83	19	.	.	PUNCT
ajst-25617	84	1	some	some	DET
ajst-25617	84	2	vaccines	vaccine	NOUN
ajst-25617	84	3	are	be	AUX
ajst-25617	84	4	undergoing	undergo	VERB
ajst-25617	84	5	early	early	ADJ
ajst-25617	84	6	-	-	PUNCT
ajst-25617	84	7	phase	phase	NOUN
ajst-25617	84	8	clinical	clinical	ADJ
ajst-25617	84	9	trials	trial	NOUN
ajst-25617	84	10	to	to	PART
ajst-25617	84	11	assess	assess	VERB
ajst-25617	84	12	their	their	PRON
ajst-25617	84	13	safety	safety	NOUN
ajst-25617	84	14	and	and	CCONJ
ajst-25617	84	15	immunogenicity	immunogenicity	NOUN
ajst-25617	84	16	.	.	PUNCT
ajst-25617	85	1	other	other	ADJ
ajst-25617	85	2	vaccines	vaccine	NOUN
ajst-25617	85	3	,	,	PUNCT
ajst-25617	85	4	such	such	ADJ
ajst-25617	85	5	as	as	ADP
ajst-25617	85	6	mrna	mrna	NOUN
ajst-25617	85	7	-	-	PUNCT
ajst-25617	85	8	based	base	VERB
ajst-25617	85	9	cancer	cancer	NOUN
ajst-25617	85	10	vaccines	vaccine	NOUN
ajst-25617	85	11	,	,	PUNCT
ajst-25617	85	12	are	be	AUX
ajst-25617	85	13	exploring	explore	VERB
ajst-25617	85	14	combination	combination	NOUN
ajst-25617	85	15	therapy	therapy	NOUN
ajst-25617	85	16	with	with	ADP
ajst-25617	85	17	other	other	ADJ
ajst-25617	85	18	treatments	treatment	NOUN
ajst-25617	85	19	,	,	PUNCT
ajst-25617	85	20	such	such	ADJ
ajst-25617	85	21	as	as	ADP
ajst-25617	85	22	immune	immune	ADJ
ajst-25617	85	23	checkpoint	checkpoint	NOUN
ajst-25617	85	24	inhibitors	inhibitor	NOUN
ajst-25617	85	25	,	,	PUNCT
ajst-25617	85	26	to	to	PART
ajst-25617	85	27	improve	improve	VERB
ajst-25617	85	28	therapeutic	therapeutic	ADJ
ajst-25617	85	29	effects	effect	NOUN
ajst-25617	85	30	.	.	PUNCT
ajst-25617	86	1	overall	overall	ADV
ajst-25617	86	2	,	,	PUNCT
ajst-25617	86	3	til	til	ADV
ajst-25617	86	4	therapy	therapy	NOUN
ajst-25617	86	5	and	and	CCONJ
ajst-25617	86	6	cancer	cancer	NOUN
ajst-25617	86	7	vaccines	vaccine	NOUN
ajst-25617	86	8	are	be	AUX
ajst-25617	86	9	promising	promise	VERB
ajst-25617	86	10	immunotherapy	immunotherapy	NOUN
ajst-25617	86	11	strategies	strategy	NOUN
ajst-25617	86	12	that	that	PRON
ajst-25617	86	13	are	be	AUX
ajst-25617	86	14	continuously	continuously	ADV
ajst-25617	86	15	being	be	AUX
ajst-25617	86	16	developed	develop	VERB
ajst-25617	86	17	and	and	CCONJ
ajst-25617	86	18	refined	refine	VERB
ajst-25617	86	19	to	to	PART
ajst-25617	86	20	provide	provide	VERB
ajst-25617	86	21	more	more	ADV
ajst-25617	86	22	effective	effective	ADJ
ajst-25617	86	23	and	and	CCONJ
ajst-25617	86	24	personalized	personalized	ADJ
ajst-25617	86	25	treatment	treatment	NOUN
ajst-25617	86	26	options	option	NOUN
ajst-25617	86	27	for	for	ADP
ajst-25617	86	28	cancer	cancer	NOUN
ajst-25617	86	29	patients	patient	NOUN
ajst-25617	86	30	.	.	PUNCT
ajst-25617	87	1	with	with	ADP
ajst-25617	87	2	further	further	ADJ
ajst-25617	87	3	clinical	clinical	ADJ
ajst-25617	87	4	research	research	NOUN
ajst-25617	87	5	,	,	PUNCT
ajst-25617	87	6	the	the	DET
ajst-25617	87	7	effectiveness	effectiveness	NOUN
ajst-25617	87	8	and	and	CCONJ
ajst-25617	87	9	safety	safety	NOUN
ajst-25617	87	10	of	of	ADP
ajst-25617	87	11	these	these	DET
ajst-25617	87	12	treatment	treatment	NOUN
ajst-25617	87	13	approaches	approach	NOUN
ajst-25617	87	14	will	will	AUX
ajst-25617	87	15	be	be	AUX
ajst-25617	87	16	further	far	ADV
ajst-25617	87	17	validated	validate	VERB
ajst-25617	87	18	and	and	CCONJ
ajst-25617	87	19	optimized	optimize	VERB
ajst-25617	87	20	.	.	PUNCT
ajst-25617	88	1	γδt	γδt	PROPN
ajst-25617	88	2	cell	cell	NOUN
ajst-25617	88	3	therapy	therapy	NOUN
ajst-25617	88	4	:	:	PUNCT
ajst-25617	88	5	γδt	γδt	PROPN
ajst-25617	88	6	cells	cell	NOUN
ajst-25617	88	7	are	be	AUX
ajst-25617	88	8	a	a	DET
ajst-25617	88	9	type	type	NOUN
ajst-25617	88	10	of	of	ADP
ajst-25617	88	11	unconventional	unconventional	ADJ
ajst-25617	88	12	t	t	NOUN
ajst-25617	88	13	cell	cell	NOUN
ajst-25617	88	14	that	that	PRON
ajst-25617	88	15	recognizes	recognize	VERB
ajst-25617	88	16	non	non	ADJ
ajst-25617	88	17	-	-	ADJ
ajst-25617	88	18	peptidic	peptidic	ADJ
ajst-25617	88	19	antigens	antigen	NOUN
ajst-25617	88	20	through	through	ADP
ajst-25617	88	21	t	t	NOUN
ajst-25617	88	22	cell	cell	NOUN
ajst-25617	88	23	receptors	receptor	NOUN
ajst-25617	88	24	composed	compose	VERB
ajst-25617	88	25	of	of	ADP
ajst-25617	88	26	γ	γ	PROPN
ajst-25617	88	27	and	and	CCONJ
ajst-25617	88	28	δ	δ	PROPN
ajst-25617	88	29	chains	chain	NOUN
ajst-25617	88	30	.	.	PUNCT
ajst-25617	89	1	they	they	PRON
ajst-25617	89	2	play	play	VERB
ajst-25617	89	3	crucial	crucial	ADJ
ajst-25617	89	4	roles	role	NOUN
ajst-25617	89	5	in	in	ADP
ajst-25617	89	6	early	early	ADJ
ajst-25617	89	7	immune	immune	ADJ
ajst-25617	89	8	responses	response	NOUN
ajst-25617	89	9	and	and	CCONJ
ajst-25617	89	10	mucosal	mucosal	NOUN
ajst-25617	89	11	immunity	immunity	NOUN
ajst-25617	89	12	.	.	PUNCT
ajst-25617	90	1	in	in	ADP
ajst-25617	90	2	cancer	cancer	NOUN
ajst-25617	90	3	treatment	treatment	NOUN
ajst-25617	90	4	,	,	PUNCT
ajst-25617	90	5	γδt	γδt	VERB
ajst-25617	90	6	cells	cell	NOUN
ajst-25617	90	7	can	can	AUX
ajst-25617	90	8	directly	directly	ADV
ajst-25617	90	9	kill	kill	VERB
ajst-25617	90	10	tumor	tumor	NOUN
ajst-25617	90	11	cells	cell	NOUN
ajst-25617	90	12	or	or	CCONJ
ajst-25617	90	13	enhance	enhance	VERB
ajst-25617	90	14	antitumor	antitumor	NOUN
ajst-25617	90	15	effects	effect	NOUN
ajst-25617	90	16	by	by	ADP
ajst-25617	90	17	secreting	secrete	VERB
ajst-25617	90	18	cytokines	cytokine	NOUN
ajst-25617	90	19	and	and	CCONJ
ajst-25617	90	20	modulating	modulate	VERB
ajst-25617	90	21	immune	immune	ADJ
ajst-25617	90	22	responses	response	NOUN
ajst-25617	90	23	.	.	PUNCT
ajst-25617	91	1	although	although	SCONJ
ajst-25617	91	2	γδt	γδt	VERB
ajst-25617	91	3	cell	cell	NOUN
ajst-25617	91	4	therapy	therapy	NOUN
ajst-25617	91	5	has	have	AUX
ajst-25617	91	6	shown	show	VERB
ajst-25617	91	7	potential	potential	ADJ
ajst-25617	91	8	therapeutic	therapeutic	ADJ
ajst-25617	91	9	effects	effect	NOUN
ajst-25617	91	10	on	on	ADP
ajst-25617	91	11	certain	certain	ADJ
ajst-25617	91	12	types	type	NOUN
ajst-25617	91	13	of	of	ADP
ajst-25617	91	14	cancers	cancer	NOUN
ajst-25617	91	15	in	in	ADP
ajst-25617	91	16	some	some	DET
ajst-25617	91	17	clinical	clinical	ADJ
ajst-25617	91	18	trials	trial	NOUN
ajst-25617	91	19	,	,	PUNCT
ajst-25617	91	20	its	its	PRON
ajst-25617	91	21	exact	exact	ADJ
ajst-25617	91	22	position	position	NOUN
ajst-25617	91	23	and	and	CCONJ
ajst-25617	91	24	effectiveness	effectiveness	NOUN
ajst-25617	91	25	in	in	ADP
ajst-25617	91	26	cancer	cancer	NOUN
ajst-25617	91	27	treatment	treatment	NOUN
ajst-25617	91	28	still	still	ADV
ajst-25617	91	29	need	need	VERB
ajst-25617	91	30	further	further	ADJ
ajst-25617	91	31	research	research	NOUN
ajst-25617	91	32	and	and	CCONJ
ajst-25617	91	33	validation	validation	NOUN
ajst-25617	91	34	.	.	PUNCT
ajst-25617	92	1	3.5	3.5	NUM
ajst-25617	92	2	.	.	PUNCT
ajst-25617	92	3	progress	progress	NOUN
ajst-25617	92	4	in	in	ADP
ajst-25617	92	5	clinical	clinical	ADJ
ajst-25617	92	6	applications	application	NOUN
ajst-25617	92	7	car	car	NOUN
ajst-25617	92	8	t	t	NOUN
ajst-25617	92	9	cell	cell	NOUN
ajst-25617	92	10	therapy	therapy	NOUN
ajst-25617	92	11	,	,	PUNCT
ajst-25617	92	12	or	or	CCONJ
ajst-25617	92	13	chimeric	chimeric	ADJ
ajst-25617	92	14	antigen	antigen	ADJ
ajst-25617	92	15	receptor	receptor	NOUN
ajst-25617	92	16	t	t	NOUN
ajst-25617	92	17	cell	cell	NOUN
ajst-25617	92	18	(	(	PUNCT
ajst-25617	92	19	car	car	NOUN
ajst-25617	92	20	-	-	PUNCT
ajst-25617	92	21	t	t	NOUN
ajst-25617	92	22	)	)	PUNCT
ajst-25617	92	23	therapy	therapy	NOUN
ajst-25617	92	24	,	,	PUNCT
ajst-25617	92	25	leverages	leverage	VERB
ajst-25617	92	26	the	the	DET
ajst-25617	92	27	power	power	NOUN
ajst-25617	92	28	of	of	ADP
ajst-25617	92	29	genetic	genetic	ADJ
ajst-25617	92	30	engineering	engineering	NOUN
ajst-25617	92	31	to	to	PART
ajst-25617	92	32	transform	transform	VERB
ajst-25617	92	33	a	a	DET
ajst-25617	92	34	patient	patient	NOUN
ajst-25617	92	35	's	's	PART
ajst-25617	92	36	t	t	NOUN
ajst-25617	92	37	cells	cell	NOUN
ajst-25617	92	38	,	,	PUNCT
ajst-25617	92	39	enabling	enable	VERB
ajst-25617	92	40	them	they	PRON
ajst-25617	92	41	to	to	PART
ajst-25617	92	42	precisely	precisely	ADV
ajst-25617	92	43	identify	identify	VERB
ajst-25617	92	44	and	and	CCONJ
ajst-25617	92	45	target	target	VERB
ajst-25617	92	46	specific	specific	ADJ
ajst-25617	92	47	tumor	tumor	NOUN
ajst-25617	92	48	antigens	antigen	NOUN
ajst-25617	92	49	.	.	PUNCT
ajst-25617	93	1	while	while	SCONJ
ajst-25617	93	2	this	this	DET
ajst-25617	93	3	therapy	therapy	NOUN
ajst-25617	93	4	has	have	AUX
ajst-25617	93	5	demonstrated	demonstrate	VERB
ajst-25617	93	6	remarkable	remarkable	ADJ
ajst-25617	93	7	response	response	NOUN
ajst-25617	93	8	rates	rate	NOUN
ajst-25617	93	9	and	and	CCONJ
ajst-25617	93	10	prolonged	prolong	VERB
ajst-25617	93	11	therapeutic	therapeutic	ADJ
ajst-25617	93	12	benefits	benefit	NOUN
ajst-25617	93	13	in	in	ADP
ajst-25617	93	14	the	the	DET
ajst-25617	93	15	treatment	treatment	NOUN
ajst-25617	93	16	of	of	ADP
ajst-25617	93	17	hematological	hematological	ADJ
ajst-25617	93	18	malignancies	malignancy	NOUN
ajst-25617	93	19	like	like	ADP
ajst-25617	93	20	acute	acute	ADJ
ajst-25617	93	21	lymphoblastic	lymphoblastic	ADJ
ajst-25617	93	22	leukemia	leukemia	NOUN
ajst-25617	93	23	(	(	PUNCT
ajst-25617	93	24	all	all	PRON
ajst-25617	93	25	)	)	PUNCT
ajst-25617	93	26	and	and	CCONJ
ajst-25617	93	27	certain	certain	ADJ
ajst-25617	93	28	non	non	ADJ
ajst-25617	93	29	-	-	ADJ
ajst-25617	93	30	hodgkin	hodgkin	NOUN
ajst-25617	93	31	's	's	PART
ajst-25617	93	32	lymphoma	lymphoma	NOUN
ajst-25617	93	33	subtypes	subtype	NOUN
ajst-25617	93	34	,	,	PUNCT
ajst-25617	93	35	its	its	PRON
ajst-25617	93	36	efficacy	efficacy	NOUN
ajst-25617	93	37	in	in	ADP
ajst-25617	93	38	solid	solid	ADJ
ajst-25617	93	39	tumors	tumor	NOUN
ajst-25617	93	40	remains	remain	VERB
ajst-25617	93	41	limited	limited	ADJ
ajst-25617	93	42	.	.	PUNCT
ajst-25617	94	1	additionally	additionally	ADV
ajst-25617	94	2	,	,	PUNCT
ajst-25617	94	3	car	car	NOUN
ajst-25617	94	4	-	-	PUNCT
ajst-25617	94	5	t	t	NOUN
ajst-25617	94	6	therapy	therapy	NOUN
ajst-25617	94	7	may	may	AUX
ajst-25617	94	8	be	be	AUX
ajst-25617	94	9	accompanied	accompany	VERB
ajst-25617	94	10	by	by	ADP
ajst-25617	94	11	significant	significant	ADJ
ajst-25617	94	12	side	side	NOUN
ajst-25617	94	13	effects	effect	NOUN
ajst-25617	94	14	,	,	PUNCT
ajst-25617	94	15	including	include	VERB
ajst-25617	94	16	cytokine	cytokine	ADJ
ajst-25617	94	17	release	release	NOUN
ajst-25617	94	18	syndrome	syndrome	NOUN
ajst-25617	94	19	(	(	PUNCT
ajst-25617	94	20	crs	crs	PROPN
ajst-25617	94	21	)	)	PUNCT
ajst-25617	94	22	and	and	CCONJ
ajst-25617	94	23	neurotoxicity	neurotoxicity	NOUN
ajst-25617	94	24	,	,	PUNCT
ajst-25617	94	25	which	which	PRON
ajst-25617	94	26	are	be	AUX
ajst-25617	94	27	important	important	ADJ
ajst-25617	94	28	considerations	consideration	NOUN
ajst-25617	94	29	in	in	ADP
ajst-25617	94	30	its	its	PRON
ajst-25617	94	31	administration	administration	NOUN
ajst-25617	94	32	.	.	PUNCT
ajst-25617	95	1	cik	cik	PROPN
ajst-25617	95	2	cell	cell	NOUN
ajst-25617	95	3	therapy	therapy	NOUN
ajst-25617	95	4	:	:	PUNCT
ajst-25617	95	5	cik	cik	PROPN
ajst-25617	95	6	(	(	PUNCT
ajst-25617	95	7	cytokine	cytokine	NOUN
ajst-25617	95	8	induced	induce	VERB
ajst-25617	95	9	killer	killer	NOUN
ajst-25617	95	10	cells	cell	NOUN
ajst-25617	95	11	)	)	PUNCT
ajst-25617	95	12	is	be	AUX
ajst-25617	95	13	a	a	DET
ajst-25617	95	14	mixture	mixture	NOUN
ajst-25617	95	15	of	of	ADP
ajst-25617	95	16	immune	immune	ADJ
ajst-25617	95	17	cells	cell	NOUN
ajst-25617	95	18	expanded	expand	VERB
ajst-25617	95	19	in	in	ADP
ajst-25617	95	20	vitro	vitro	NOUN
ajst-25617	95	21	with	with	ADP
ajst-25617	95	22	a	a	DET
ajst-25617	95	23	wide	wide	ADJ
ajst-25617	95	24	range	range	NOUN
ajst-25617	95	25	of	of	ADP
ajst-25617	95	26	antitumor	antitumor	PROPN
ajst-25617	95	27	activities	activity	NOUN
ajst-25617	95	28	.	.	PUNCT
ajst-25617	96	1	cik	cik	PROPN
ajst-25617	96	2	cell	cell	NOUN
ajst-25617	96	3	therapy	therapy	NOUN
ajst-25617	96	4	has	have	AUX
ajst-25617	96	5	been	be	AUX
ajst-25617	96	6	tested	test	VERB
ajst-25617	96	7	in	in	ADP
ajst-25617	96	8	clinical	clinical	ADJ
ajst-25617	96	9	trials	trial	NOUN
ajst-25617	96	10	for	for	ADP
ajst-25617	96	11	solid	solid	ADJ
ajst-25617	96	12	tumors	tumor	NOUN
ajst-25617	96	13	such	such	ADJ
ajst-25617	96	14	as	as	ADP
ajst-25617	96	15	non	non	ADJ
ajst-25617	96	16	-	-	ADJ
ajst-25617	96	17	small	small	ADJ
ajst-25617	96	18	cell	cell	NOUN
ajst-25617	96	19	lung	lung	NOUN
ajst-25617	96	20	cancer	cancer	NOUN
ajst-25617	96	21	(	(	PUNCT
ajst-25617	96	22	nsclc	nsclc	NOUN
ajst-25617	96	23	)	)	PUNCT
ajst-25617	96	24	.	.	PUNCT
ajst-25617	97	1	the	the	DET
ajst-25617	97	2	results	result	NOUN
ajst-25617	97	3	showed	show	VERB
ajst-25617	97	4	that	that	SCONJ
ajst-25617	97	5	cik	cik	PROPN
ajst-25617	97	6	cell	cell	PROPN
ajst-25617	97	7	combined	combine	VERB
ajst-25617	97	8	chemotherapy	chemotherapy	NOUN
ajst-25617	97	9	had	have	VERB
ajst-25617	97	10	better	well	ADJ
ajst-25617	97	11	disease	disease	NOUN
ajst-25617	97	12	control	control	NOUN
ajst-25617	97	13	rates	rate	NOUN
ajst-25617	97	14	and	and	CCONJ
ajst-25617	97	15	improved	improved	ADJ
ajst-25617	97	16	survival	survival	NOUN
ajst-25617	97	17	than	than	ADP
ajst-25617	97	18	chemotherapy	chemotherapy	VERB
ajst-25617	97	19	alone	alone	ADV
ajst-25617	97	20	.	.	PUNCT
ajst-25617	98	1	dendritic	dendritic	ADJ
ajst-25617	98	2	cell	cell	NOUN
ajst-25617	98	3	vaccine	vaccine	NOUN
ajst-25617	98	4	therapy	therapy	NOUN
ajst-25617	98	5	:	:	PUNCT
ajst-25617	98	6	dendritic	dendritic	ADJ
ajst-25617	98	7	cells	cell	NOUN
ajst-25617	98	8	(	(	PUNCT
ajst-25617	98	9	dcs	dcs	PROPN
ajst-25617	98	10	)	)	PUNCT
ajst-25617	98	11	are	be	AUX
ajst-25617	98	12	powerful	powerful	ADJ
ajst-25617	98	13	antigen	antigen	NOUN
ajst-25617	98	14	-	-	PUNCT
ajst-25617	98	15	presenting	present	VERB
ajst-25617	98	16	cells	cell	NOUN
ajst-25617	98	17	that	that	PRON
ajst-25617	98	18	activate	activate	VERB
ajst-25617	98	19	t	t	NOUN
ajst-25617	98	20	cell	cell	NOUN
ajst-25617	98	21	immune	immune	ADJ
ajst-25617	98	22	responses	response	NOUN
ajst-25617	98	23	against	against	ADP
ajst-25617	98	24	tumors	tumor	NOUN
ajst-25617	98	25	.	.	PUNCT
ajst-25617	99	1	dendritic	dendritic	ADJ
ajst-25617	99	2	cell	cell	NOUN
ajst-25617	99	3	vaccine	vaccine	NOUN
ajst-25617	99	4	therapy	therapy	NOUN
ajst-25617	99	5	involves	involve	VERB
ajst-25617	99	6	loading	load	VERB
ajst-25617	99	7	tumor	tumor	NOUN
ajst-25617	99	8	antigens	antigen	NOUN
ajst-25617	99	9	onto	onto	ADP
ajst-25617	99	10	dendritic	dendritic	ADJ
ajst-25617	99	11	cells	cell	NOUN
ajst-25617	99	12	,	,	PUNCT
ajst-25617	99	13	which	which	PRON
ajst-25617	99	14	are	be	AUX
ajst-25617	99	15	then	then	ADV
ajst-25617	99	16	re	re	VERB
ajst-25617	99	17	-	-	VERB
ajst-25617	99	18	injected	inject	VERB
ajst-25617	99	19	into	into	ADP
ajst-25617	99	20	the	the	DET
ajst-25617	99	21	patient	patient	NOUN
ajst-25617	99	22	to	to	PART
ajst-25617	99	23	activate	activate	VERB
ajst-25617	99	24	a	a	DET
ajst-25617	99	25	specific	specific	ADJ
ajst-25617	99	26	antitumor	antitumor	PROPN
ajst-25617	99	27	immune	immune	ADJ
ajst-25617	99	28	response	response	NOUN
ajst-25617	99	29	.	.	PUNCT
ajst-25617	100	1	although	although	SCONJ
ajst-25617	100	2	dendritic	dendritic	ADJ
ajst-25617	100	3	cell	cell	NOUN
ajst-25617	100	4	vaccine	vaccine	NOUN
ajst-25617	100	5	therapy	therapy	NOUN
ajst-25617	100	6	has	have	AUX
ajst-25617	100	7	shown	show	VERB
ajst-25617	100	8	some	some	DET
ajst-25617	100	9	effectiveness	effectiveness	NOUN
ajst-25617	100	10	in	in	ADP
ajst-25617	100	11	some	some	DET
ajst-25617	100	12	clinical	clinical	ADJ
ajst-25617	100	13	trials	trial	NOUN
ajst-25617	100	14	,	,	PUNCT
ajst-25617	100	15	its	its	PRON
ajst-25617	100	16	effectiveness	effectiveness	NOUN
ajst-25617	100	17	compared	compare	VERB
ajst-25617	100	18	to	to	ADP
ajst-25617	100	19	existing	exist	VERB
ajst-25617	100	20	treatments	treatment	NOUN
ajst-25617	100	21	still	still	ADV
ajst-25617	100	22	needs	need	VERB
ajst-25617	100	23	to	to	PART
ajst-25617	100	24	be	be	AUX
ajst-25617	100	25	further	far	ADV
ajst-25617	100	26	confirmed	confirm	VERB
ajst-25617	100	27	.	.	PUNCT
ajst-25617	101	1	immune	immune	ADJ
ajst-25617	101	2	checkpoint	checkpoint	NOUN
ajst-25617	101	3	inhibitors	inhibitor	NOUN
ajst-25617	101	4	:	:	PUNCT
ajst-25617	101	5	immune	immune	ADJ
ajst-25617	101	6	checkpoint	checkpoint	NOUN
ajst-25617	101	7	inhibitors	inhibitor	NOUN
ajst-25617	101	8	such	such	ADJ
ajst-25617	101	9	as	as	ADP
ajst-25617	101	10	pd-1	pd-1	ADP
ajst-25617	101	11	/	/	SYM
ajst-25617	101	12	pd	pd	NOUN
ajst-25617	101	13	-	-	PROPN
ajst-25617	101	14	l1	l1	PROPN
ajst-25617	101	15	and	and	CCONJ
ajst-25617	101	16	ctla-4	ctla-4	NOUN
ajst-25617	101	17	inhibitors	inhibitor	NOUN
ajst-25617	101	18	activate	activate	VERB
ajst-25617	101	19	the	the	DET
ajst-25617	101	20	antitumor	antitumor	PROPN
ajst-25617	101	21	activity	activity	NOUN
ajst-25617	101	22	of	of	ADP
ajst-25617	101	23	t	t	NOUN
ajst-25617	101	24	cells	cell	NOUN
ajst-25617	101	25	by	by	ADP
ajst-25617	101	26	reducing	reduce	VERB
ajst-25617	101	27	the	the	DET
ajst-25617	101	28	suppression	suppression	NOUN
ajst-25617	101	29	of	of	ADP
ajst-25617	101	30	the	the	DET
ajst-25617	101	31	immune	immune	ADJ
ajst-25617	101	32	system	system	NOUN
ajst-25617	101	33	by	by	ADP
ajst-25617	101	34	tumors	tumor	NOUN
ajst-25617	101	35	.	.	PUNCT
ajst-25617	102	1	these	these	DET
ajst-25617	102	2	inhibitors	inhibitor	NOUN
ajst-25617	102	3	have	have	AUX
ajst-25617	102	4	shown	show	VERB
ajst-25617	102	5	significant	significant	ADJ
ajst-25617	102	6	therapeutic	therapeutic	ADJ
ajst-25617	102	7	efficacy	efficacy	NOUN
ajst-25617	102	8	and	and	CCONJ
ajst-25617	102	9	improved	improved	ADJ
ajst-25617	102	10	survival	survival	NOUN
ajst-25617	102	11	in	in	ADP
ajst-25617	102	12	a	a	DET
ajst-25617	102	13	variety	variety	NOUN
ajst-25617	102	14	of	of	ADP
ajst-25617	102	15	cancers	cancer	NOUN
ajst-25617	102	16	,	,	PUNCT
ajst-25617	102	17	such	such	ADJ
ajst-25617	102	18	as	as	ADP
ajst-25617	102	19	melanoma	melanoma	NOUN
ajst-25617	102	20	,	,	PUNCT
ajst-25617	102	21	lung	lung	NOUN
ajst-25617	102	22	cancer	cancer	NOUN
ajst-25617	102	23	,	,	PUNCT
ajst-25617	102	24	and	and	CCONJ
ajst-25617	102	25	kidney	kidney	NOUN
ajst-25617	102	26	cancer	cancer	NOUN
ajst-25617	102	27	.	.	PUNCT
ajst-25617	103	1	however	however	ADV
ajst-25617	103	2	,	,	PUNCT
ajst-25617	103	3	not	not	PART
ajst-25617	103	4	all	all	DET
ajst-25617	103	5	patients	patient	NOUN
ajst-25617	103	6	respond	respond	VERB
ajst-25617	103	7	to	to	ADP
ajst-25617	103	8	these	these	DET
ajst-25617	103	9	therapies	therapy	NOUN
ajst-25617	103	10	,	,	PUNCT
ajst-25617	103	11	and	and	CCONJ
ajst-25617	103	12	they	they	PRON
ajst-25617	103	13	may	may	AUX
ajst-25617	103	14	be	be	AUX
ajst-25617	103	15	associated	associate	VERB
ajst-25617	103	16	with	with	ADP
ajst-25617	103	17	immune	immune	NOUN
ajst-25617	103	18	-	-	PUNCT
ajst-25617	103	19	related	relate	VERB
ajst-25617	103	20	side	side	NOUN
ajst-25617	103	21	effects	effect	NOUN
ajst-25617	103	22	.	.	PUNCT
ajst-25617	104	1	γδt	γδt	PROPN
ajst-25617	104	2	cell	cell	NOUN
ajst-25617	104	3	therapy	therapy	NOUN
ajst-25617	104	4	:	:	PUNCT
ajst-25617	104	5	γδt	γδt	PROPN
ajst-25617	104	6	cells	cell	NOUN
ajst-25617	104	7	are	be	AUX
ajst-25617	104	8	a	a	DET
ajst-25617	104	9	special	special	ADJ
ajst-25617	104	10	subset	subset	NOUN
ajst-25617	104	11	of	of	ADP
ajst-25617	104	12	t	t	NOUN
ajst-25617	104	13	cells	cell	NOUN
ajst-25617	104	14	that	that	PRON
ajst-25617	104	15	can	can	AUX
ajst-25617	104	16	recognize	recognize	VERB
ajst-25617	104	17	non	non	ADJ
ajst-25617	104	18	-	-	ADJ
ajst-25617	104	19	peptide	peptide	ADJ
ajst-25617	104	20	antigens	antigen	NOUN
ajst-25617	104	21	.	.	PUNCT
ajst-25617	105	1	γδt	γδt	NOUN
ajst-25617	105	2	cell	cell	NOUN
ajst-25617	105	3	therapy	therapy	NOUN
ajst-25617	105	4	has	have	AUX
ajst-25617	105	5	shown	show	VERB
ajst-25617	105	6	potential	potential	ADJ
ajst-25617	105	7	therapeutic	therapeutic	ADJ
ajst-25617	105	8	effects	effect	NOUN
ajst-25617	105	9	for	for	ADP
ajst-25617	105	10	certain	certain	ADJ
ajst-25617	105	11	cancer	cancer	NOUN
ajst-25617	105	12	types	type	NOUN
ajst-25617	105	13	in	in	ADP
ajst-25617	105	14	some	some	DET
ajst-25617	105	15	clinical	clinical	ADJ
ajst-25617	105	16	trials	trial	NOUN
ajst-25617	105	17	,	,	PUNCT
ajst-25617	105	18	but	but	CCONJ
ajst-25617	105	19	more	more	ADJ
ajst-25617	105	20	research	research	NOUN
ajst-25617	105	21	is	be	AUX
ajst-25617	105	22	needed	need	VERB
ajst-25617	105	23	to	to	PART
ajst-25617	105	24	determine	determine	VERB
ajst-25617	105	25	its	its	PRON
ajst-25617	105	26	exact	exact	ADJ
ajst-25617	105	27	role	role	NOUN
ajst-25617	105	28	in	in	ADP
ajst-25617	105	29	cancer	cancer	NOUN
ajst-25617	105	30	treatment	treatment	NOUN
ajst-25617	105	31	.	.	PUNCT
ajst-25617	106	1	overall	overall	ADJ
ajst-25617	106	2	,	,	PUNCT
ajst-25617	106	3	cell	cell	NOUN
ajst-25617	106	4	immunotherapy	immunotherapy	NOUN
ajst-25617	106	5	has	have	AUX
ajst-25617	106	6	made	make	VERB
ajst-25617	106	7	progress	progress	NOUN
ajst-25617	106	8	in	in	ADP
ajst-25617	106	9	improving	improve	VERB
ajst-25617	106	10	the	the	DET
ajst-25617	106	11	survival	survival	NOUN
ajst-25617	106	12	and	and	CCONJ
ajst-25617	106	13	quality	quality	NOUN
ajst-25617	106	14	of	of	ADP
ajst-25617	106	15	life	life	NOUN
ajst-25617	106	16	of	of	ADP
ajst-25617	106	17	some	some	DET
ajst-25617	106	18	cancer	cancer	NOUN
ajst-25617	106	19	patients	patient	NOUN
ajst-25617	106	20	,	,	PUNCT
ajst-25617	106	21	but	but	CCONJ
ajst-25617	106	22	it	it	PRON
ajst-25617	106	23	still	still	ADV
ajst-25617	106	24	faces	face	VERB
ajst-25617	106	25	challenges	challenge	NOUN
ajst-25617	106	26	such	such	ADJ
ajst-25617	106	27	as	as	ADP
ajst-25617	106	28	low	low	ADJ
ajst-25617	106	29	response	response	NOUN
ajst-25617	106	30	rates	rate	NOUN
ajst-25617	106	31	,	,	PUNCT
ajst-25617	106	32	side	side	ADJ
ajst-25617	106	33	effect	effect	NOUN
ajst-25617	106	34	management	management	NOUN
ajst-25617	106	35	,	,	PUNCT
ajst-25617	106	36	and	and	CCONJ
ajst-25617	106	37	effectiveness	effectiveness	NOUN
ajst-25617	106	38	in	in	ADP
ajst-25617	106	39	solid	solid	ADJ
ajst-25617	106	40	tumors	tumor	NOUN
ajst-25617	106	41	.	.	PUNCT
ajst-25617	107	1	194	194	NUM
ajst-25617	107	2	future	future	ADJ
ajst-25617	107	3	research	research	NOUN
ajst-25617	107	4	needs	need	VERB
ajst-25617	107	5	to	to	PART
ajst-25617	107	6	further	far	ADV
ajst-25617	107	7	optimize	optimize	VERB
ajst-25617	107	8	treatment	treatment	NOUN
ajst-25617	107	9	methods	method	NOUN
ajst-25617	107	10	,	,	PUNCT
ajst-25617	107	11	improve	improve	VERB
ajst-25617	107	12	therapeutic	therapeutic	ADJ
ajst-25617	107	13	effects	effect	NOUN
ajst-25617	107	14	,	,	PUNCT
ajst-25617	107	15	and	and	CCONJ
ajst-25617	107	16	provide	provide	VERB
ajst-25617	107	17	more	more	ADJ
ajst-25617	107	18	personalized	personalized	ADJ
ajst-25617	107	19	treatment	treatment	NOUN
ajst-25617	107	20	options	option	NOUN
ajst-25617	107	21	for	for	ADP
ajst-25617	107	22	patients	patient	NOUN
ajst-25617	107	23	.	.	PUNCT
ajst-25617	108	1	3.6	3.6	NUM
ajst-25617	108	2	.	.	PUNCT
ajst-25617	109	1	challenges	challenge	NOUN
ajst-25617	109	2	facing	face	VERB
ajst-25617	109	3	cell	cell	NOUN
ajst-25617	109	4	immunotherapy	immunotherapy	NOUN
ajst-25617	109	5	drug	drug	NOUN
ajst-25617	109	6	resistance	resistance	NOUN
ajst-25617	109	7	is	be	AUX
ajst-25617	109	8	a	a	DET
ajst-25617	109	9	significant	significant	ADJ
ajst-25617	109	10	factor	factor	NOUN
ajst-25617	109	11	leading	lead	VERB
ajst-25617	109	12	to	to	ADP
ajst-25617	109	13	poor	poor	ADJ
ajst-25617	109	14	therapeutic	therapeutic	ADJ
ajst-25617	109	15	outcomes	outcome	NOUN
ajst-25617	109	16	,	,	PUNCT
ajst-25617	109	17	a	a	DET
ajst-25617	109	18	problem	problem	NOUN
ajst-25617	109	19	that	that	PRON
ajst-25617	109	20	exists	exist	VERB
ajst-25617	109	21	in	in	ADP
ajst-25617	109	22	chemotherapy	chemotherapy	NOUN
ajst-25617	109	23	,	,	PUNCT
ajst-25617	109	24	radiotherapy	radiotherapy	NOUN
ajst-25617	109	25	,	,	PUNCT
ajst-25617	109	26	and	and	CCONJ
ajst-25617	109	27	targeted	target	VERB
ajst-25617	109	28	drug	drug	NOUN
ajst-25617	109	29	therapy	therapy	NOUN
ajst-25617	109	30	for	for	ADP
ajst-25617	109	31	tumors	tumor	NOUN
ajst-25617	109	32	,	,	PUNCT
ajst-25617	109	33	and	and	CCONJ
ajst-25617	109	34	is	be	AUX
ajst-25617	109	35	also	also	ADV
ajst-25617	109	36	unavoidable	unavoidable	ADJ
ajst-25617	109	37	in	in	ADP
ajst-25617	109	38	immunotherapy	immunotherapy	NOUN
ajst-25617	109	39	.	.	PUNCT
ajst-25617	110	1	intrinsic	intrinsic	ADJ
ajst-25617	110	2	factors	factor	NOUN
ajst-25617	110	3	of	of	ADP
ajst-25617	110	4	patients	patient	NOUN
ajst-25617	110	5	,	,	PUNCT
ajst-25617	110	6	such	such	ADJ
ajst-25617	110	7	as	as	ADP
ajst-25617	110	8	their	their	PRON
ajst-25617	110	9	genome	genome	NOUN
ajst-25617	110	10	,	,	PUNCT
ajst-25617	110	11	epigenome	epigenome	NOUN
ajst-25617	110	12	,	,	PUNCT
ajst-25617	110	13	and	and	CCONJ
ajst-25617	110	14	autoimmune	autoimmune	ADJ
ajst-25617	110	15	system	system	NOUN
ajst-25617	110	16	,	,	PUNCT
ajst-25617	110	17	contribute	contribute	VERB
ajst-25617	110	18	to	to	ADP
ajst-25617	110	19	and	and	CCONJ
ajst-25617	110	20	determine	determine	VERB
ajst-25617	110	21	their	their	PRON
ajst-25617	110	22	response	response	NOUN
ajst-25617	110	23	to	to	ADP
ajst-25617	110	24	therapeutic	therapeutic	ADJ
ajst-25617	110	25	drugs	drug	NOUN
ajst-25617	110	26	.	.	PUNCT
ajst-25617	111	1	additionally	additionally	ADV
ajst-25617	111	2	,	,	PUNCT
ajst-25617	111	3	as	as	SCONJ
ajst-25617	111	4	treatment	treatment	NOUN
ajst-25617	111	5	drugs	drug	NOUN
ajst-25617	111	6	are	be	AUX
ajst-25617	111	7	exposed	expose	VERB
ajst-25617	111	8	and	and	CCONJ
ajst-25617	111	9	accumulate	accumulate	VERB
ajst-25617	111	10	during	during	ADP
ajst-25617	111	11	therapy	therapy	NOUN
ajst-25617	111	12	,	,	PUNCT
ajst-25617	111	13	the	the	DET
ajst-25617	111	14	tumor	tumor	NOUN
ajst-25617	111	15	and	and	CCONJ
ajst-25617	111	16	immune	immune	ADJ
ajst-25617	111	17	microenvironment	microenvironment	NOUN
ajst-25617	111	18	of	of	ADP
ajst-25617	111	19	the	the	DET
ajst-25617	111	20	patient	patient	NOUN
ajst-25617	111	21	will	will	AUX
ajst-25617	111	22	also	also	ADV
ajst-25617	111	23	evolve	evolve	VERB
ajst-25617	111	24	accordingly	accordingly	ADV
ajst-25617	111	25	,	,	PUNCT
ajst-25617	111	26	which	which	PRON
ajst-25617	111	27	may	may	AUX
ajst-25617	111	28	also	also	ADV
ajst-25617	111	29	affect	affect	VERB
ajst-25617	111	30	the	the	DET
ajst-25617	111	31	drug	drug	NOUN
ajst-25617	111	32	's	's	PART
ajst-25617	111	33	effectiveness	effectiveness	NOUN
ajst-25617	111	34	.	.	PUNCT
ajst-25617	112	1	although	although	SCONJ
ajst-25617	112	2	cell	cell	NOUN
ajst-25617	112	3	immunotherapy	immunotherapy	NOUN
ajst-25617	112	4	,	,	PUNCT
ajst-25617	112	5	especially	especially	ADV
ajst-25617	112	6	car	car	NOUN
ajst-25617	112	7	-	-	PUNCT
ajst-25617	112	8	t	t	NOUN
ajst-25617	112	9	therapy	therapy	NOUN
ajst-25617	112	10	,	,	PUNCT
ajst-25617	112	11	has	have	AUX
ajst-25617	112	12	shown	show	VERB
ajst-25617	112	13	great	great	ADJ
ajst-25617	112	14	potential	potential	NOUN
ajst-25617	112	15	in	in	ADP
ajst-25617	112	16	the	the	DET
ajst-25617	112	17	field	field	NOUN
ajst-25617	112	18	of	of	ADP
ajst-25617	112	19	cancer	cancer	NOUN
ajst-25617	112	20	treatment	treatment	NOUN
ajst-25617	112	21	,	,	PUNCT
ajst-25617	112	22	it	it	PRON
ajst-25617	112	23	still	still	ADV
ajst-25617	112	24	faces	face	VERB
ajst-25617	112	25	challenges	challenge	NOUN
ajst-25617	112	26	such	such	ADJ
ajst-25617	112	27	as	as	ADP
ajst-25617	112	28	high	high	ADJ
ajst-25617	112	29	cost	cost	NOUN
ajst-25617	112	30	,	,	PUNCT
ajst-25617	112	31	safety	safety	NOUN
ajst-25617	112	32	issues	issue	NOUN
ajst-25617	112	33	,	,	PUNCT
ajst-25617	112	34	and	and	CCONJ
ajst-25617	112	35	durability	durability	NOUN
ajst-25617	112	36	of	of	ADP
ajst-25617	112	37	therapeutic	therapeutic	ADJ
ajst-25617	112	38	effects	effect	NOUN
ajst-25617	112	39	.	.	PUNCT
ajst-25617	113	1	to	to	PART
ajst-25617	113	2	reduce	reduce	VERB
ajst-25617	113	3	costs	cost	NOUN
ajst-25617	113	4	,	,	PUNCT
ajst-25617	113	5	researchers	researcher	NOUN
ajst-25617	113	6	are	be	AUX
ajst-25617	113	7	exploring	explore	VERB
ajst-25617	113	8	automated	automate	VERB
ajst-25617	113	9	production	production	NOUN
ajst-25617	113	10	and	and	CCONJ
ajst-25617	113	11	economies	economy	NOUN
ajst-25617	113	12	of	of	ADP
ajst-25617	113	13	scale	scale	NOUN
ajst-25617	113	14	,	,	PUNCT
ajst-25617	113	15	while	while	SCONJ
ajst-25617	113	16	introducing	introduce	VERB
ajst-25617	113	17	"	"	PUNCT
ajst-25617	113	18	safety	safety	NOUN
ajst-25617	113	19	switches	switch	NOUN
ajst-25617	113	20	"	"	PUNCT
ajst-25617	113	21	and	and	CCONJ
ajst-25617	113	22	optimizing	optimize	VERB
ajst-25617	113	23	car	car	NOUN
ajst-25617	113	24	-	-	PUNCT
ajst-25617	113	25	t	t	NOUN
ajst-25617	113	26	cell	cell	NOUN
ajst-25617	113	27	design	design	NOUN
ajst-25617	113	28	to	to	PART
ajst-25617	113	29	improve	improve	VERB
ajst-25617	113	30	the	the	DET
ajst-25617	113	31	safety	safety	NOUN
ajst-25617	113	32	and	and	CCONJ
ajst-25617	113	33	durability	durability	NOUN
ajst-25617	113	34	of	of	ADP
ajst-25617	113	35	treatment	treatment	NOUN
ajst-25617	113	36	.	.	PUNCT
ajst-25617	114	1	these	these	DET
ajst-25617	114	2	technological	technological	ADJ
ajst-25617	114	3	advancements	advancement	NOUN
ajst-25617	114	4	are	be	AUX
ajst-25617	114	5	gradually	gradually	ADV
ajst-25617	114	6	pushing	push	VERB
ajst-25617	114	7	cell	cell	NOUN
ajst-25617	114	8	immunotherapy	immunotherapy	NOUN
ajst-25617	114	9	towards	towards	ADP
ajst-25617	114	10	more	more	ADV
ajst-25617	114	11	economical	economical	ADJ
ajst-25617	114	12	,	,	PUNCT
ajst-25617	114	13	safer	safe	ADJ
ajst-25617	114	14	,	,	PUNCT
ajst-25617	114	15	and	and	CCONJ
ajst-25617	114	16	more	more	ADV
ajst-25617	114	17	effective	effective	ADJ
ajst-25617	114	18	directions	direction	NOUN
ajst-25617	114	19	.	.	PUNCT
ajst-25617	115	1	the	the	DET
ajst-25617	115	2	advent	advent	NOUN
ajst-25617	115	3	of	of	ADP
ajst-25617	115	4	immune	immune	ADJ
ajst-25617	115	5	checkpoint	checkpoint	NOUN
ajst-25617	115	6	inhibitors	inhibitor	NOUN
ajst-25617	115	7	and	and	CCONJ
ajst-25617	115	8	their	their	PRON
ajst-25617	115	9	success	success	NOUN
ajst-25617	115	10	in	in	ADP
ajst-25617	115	11	the	the	DET
ajst-25617	115	12	treatment	treatment	NOUN
ajst-25617	115	13	of	of	ADP
ajst-25617	115	14	cancer	cancer	NOUN
ajst-25617	115	15	made	make	VERB
ajst-25617	115	16	tumor	tumor	NOUN
ajst-25617	115	17	immunotherapy	immunotherapy	NOUN
ajst-25617	115	18	number	number	NOUN
ajst-25617	115	19	one	one	NUM
ajst-25617	115	20	on	on	ADP
ajst-25617	115	21	science	science	NOUN
ajst-25617	115	22	magazine	magazine	NOUN
ajst-25617	115	23	's	's	PART
ajst-25617	115	24	top	top	ADJ
ajst-25617	115	25	10	10	NUM
ajst-25617	115	26	scientific	scientific	ADJ
ajst-25617	115	27	breakthroughs	breakthrough	NOUN
ajst-25617	115	28	in	in	ADP
ajst-25617	115	29	2013	2013	NUM
ajst-25617	115	30	.	.	PUNCT
ajst-25617	116	1	even	even	ADV
ajst-25617	116	2	so	so	ADV
ajst-25617	116	3	,	,	PUNCT
ajst-25617	116	4	however	however	ADV
ajst-25617	116	5	,	,	PUNCT
ajst-25617	116	6	their	their	PRON
ajst-25617	116	7	clinical	clinical	ADJ
ajst-25617	116	8	effectiveness	effectiveness	NOUN
ajst-25617	116	9	is	be	AUX
ajst-25617	116	10	limited	limited	ADJ
ajst-25617	116	11	.	.	PUNCT
ajst-25617	117	1	for	for	ADP
ajst-25617	117	2	example	example	NOUN
ajst-25617	117	3	,	,	PUNCT
ajst-25617	117	4	anti	anti	ADJ
ajst-25617	117	5	-	-	ADJ
ajst-25617	117	6	pd-1	pd-1	ADJ
ajst-25617	117	7	/pdl1	/pdl1	NOUN
ajst-25617	117	8	antibodies	antibody	NOUN
ajst-25617	117	9	in	in	ADP
ajst-25617	117	10	the	the	DET
ajst-25617	117	11	treatment	treatment	NOUN
ajst-25617	117	12	of	of	ADP
ajst-25617	117	13	esophageal	esophageal	ADJ
ajst-25617	117	14	cancer	cancer	NOUN
ajst-25617	117	15	,	,	PUNCT
ajst-25617	117	16	prostate	prostate	NOUN
ajst-25617	117	17	cancer	cancer	NOUN
ajst-25617	117	18	,	,	PUNCT
ajst-25617	117	19	pancreatic	pancreatic	ADJ
ajst-25617	117	20	cancer	cancer	NOUN
ajst-25617	117	21	,	,	PUNCT
ajst-25617	117	22	ovarian	ovarian	ADJ
ajst-25617	117	23	cancer	cancer	NOUN
ajst-25617	117	24	and	and	CCONJ
ajst-25617	117	25	other	other	ADJ
ajst-25617	117	26	tumors	tumor	NOUN
ajst-25617	117	27	,	,	PUNCT
ajst-25617	117	28	the	the	DET
ajst-25617	117	29	overall	overall	ADJ
ajst-25617	117	30	clinical	clinical	ADJ
ajst-25617	117	31	response	response	NOUN
ajst-25617	117	32	rate	rate	NOUN
ajst-25617	117	33	is	be	AUX
ajst-25617	117	34	less	less	ADJ
ajst-25617	117	35	than	than	ADP
ajst-25617	117	36	30	30	NUM
ajst-25617	117	37	%	%	NOUN
ajst-25617	117	38	.	.	PUNCT
ajst-25617	118	1	only	only	ADV
ajst-25617	118	2	in	in	ADP
ajst-25617	118	3	colorectal	colorectal	ADJ
ajst-25617	118	4	cancer	cancer	NOUN
ajst-25617	118	5	patients	patient	NOUN
ajst-25617	118	6	with	with	ADP
ajst-25617	118	7	high	high	ADJ
ajst-25617	118	8	microsatellite	microsatellite	NOUN
ajst-25617	118	9	instability	instability	NOUN
ajst-25617	118	10	did	do	AUX
ajst-25617	118	11	the	the	DET
ajst-25617	118	12	response	response	NOUN
ajst-25617	118	13	rate	rate	NOUN
ajst-25617	118	14	exceed	exceed	VERB
ajst-25617	118	15	50	50	NUM
ajst-25617	118	16	%	%	NOUN
ajst-25617	118	17	,	,	PUNCT
ajst-25617	118	18	but	but	CCONJ
ajst-25617	118	19	this	this	DET
ajst-25617	118	20	type	type	NOUN
ajst-25617	118	21	of	of	ADP
ajst-25617	118	22	colorectal	colorectal	ADJ
ajst-25617	118	23	cancer	cancer	NOUN
ajst-25617	118	24	is	be	AUX
ajst-25617	118	25	relatively	relatively	ADV
ajst-25617	118	26	rare	rare	ADJ
ajst-25617	118	27	.	.	PUNCT
ajst-25617	119	1	4	4	X
ajst-25617	119	2	.	.	X
ajst-25617	119	3	future	future	ADJ
ajst-25617	119	4	development	development	NOUN
ajst-25617	119	5	directions	direction	NOUN
ajst-25617	119	6	firstly	firstly	ADV
ajst-25617	119	7	,	,	PUNCT
ajst-25617	119	8	the	the	DET
ajst-25617	119	9	future	future	ADJ
ajst-25617	119	10	development	development	NOUN
ajst-25617	119	11	direction	direction	NOUN
ajst-25617	119	12	of	of	ADP
ajst-25617	119	13	cellular	cellular	ADJ
ajst-25617	119	14	immunotherapy	immunotherapy	NOUN
ajst-25617	119	15	can	can	AUX
ajst-25617	119	16	be	be	AUX
ajst-25617	119	17	combination	combination	NOUN
ajst-25617	119	18	therapy	therapy	NOUN
ajst-25617	119	19	.	.	PUNCT
ajst-25617	120	1	when	when	SCONJ
ajst-25617	120	2	monotherapy	monotherapy	NOUN
ajst-25617	120	3	has	have	AUX
ajst-25617	120	4	limited	limit	VERB
ajst-25617	120	5	therapeutic	therapeutic	ADJ
ajst-25617	120	6	effects	effect	NOUN
ajst-25617	120	7	,	,	PUNCT
ajst-25617	120	8	combination	combination	NOUN
ajst-25617	120	9	therapy	therapy	NOUN
ajst-25617	120	10	has	have	AUX
ajst-25617	120	11	become	become	VERB
ajst-25617	120	12	a	a	DET
ajst-25617	120	13	trend	trend	NOUN
ajst-25617	120	14	,	,	PUNCT
ajst-25617	120	15	especially	especially	ADV
ajst-25617	120	16	for	for	ADP
ajst-25617	120	17	complex	complex	ADJ
ajst-25617	120	18	immune	immune	ADJ
ajst-25617	120	19	regulation	regulation	NOUN
ajst-25617	120	20	.	.	PUNCT
ajst-25617	121	1	as	as	ADP
ajst-25617	121	2	a	a	DET
ajst-25617	121	3	complex	complex	ADJ
ajst-25617	121	4	disease	disease	NOUN
ajst-25617	121	5	,	,	PUNCT
ajst-25617	121	6	tumor	tumor	NOUN
ajst-25617	121	7	therapy	therapy	NOUN
ajst-25617	121	8	usually	usually	ADV
ajst-25617	121	9	involves	involve	VERB
ajst-25617	121	10	the	the	DET
ajst-25617	121	11	combined	combine	VERB
ajst-25617	121	12	use	use	NOUN
ajst-25617	121	13	of	of	ADP
ajst-25617	121	14	multiple	multiple	ADJ
ajst-25617	121	15	drugs	drug	NOUN
ajst-25617	121	16	,	,	PUNCT
ajst-25617	121	17	aiming	aim	VERB
ajst-25617	121	18	to	to	PART
ajst-25617	121	19	maximize	maximize	VERB
ajst-25617	121	20	therapeutic	therapeutic	ADJ
ajst-25617	121	21	effects	effect	NOUN
ajst-25617	121	22	,	,	PUNCT
ajst-25617	121	23	reduce	reduce	VERB
ajst-25617	121	24	toxic	toxic	ADJ
ajst-25617	121	25	and	and	CCONJ
ajst-25617	121	26	side	side	NOUN
ajst-25617	121	27	effects	effect	NOUN
ajst-25617	121	28	,	,	PUNCT
ajst-25617	121	29	and	and	CCONJ
ajst-25617	121	30	delay	delay	VERB
ajst-25617	121	31	the	the	DET
ajst-25617	121	32	occurrence	occurrence	NOUN
ajst-25617	121	33	of	of	ADP
ajst-25617	121	34	drug	drug	NOUN
ajst-25617	121	35	resistance	resistance	NOUN
ajst-25617	121	36	.	.	PUNCT
ajst-25617	122	1	in	in	ADP
ajst-25617	122	2	the	the	DET
ajst-25617	122	3	clinical	clinical	ADJ
ajst-25617	122	4	application	application	NOUN
ajst-25617	122	5	of	of	ADP
ajst-25617	122	6	tumor	tumor	NOUN
ajst-25617	122	7	immunotherapy	immunotherapy	NOUN
ajst-25617	122	8	,	,	PUNCT
ajst-25617	122	9	different	different	ADJ
ajst-25617	122	10	combination	combination	NOUN
ajst-25617	122	11	therapy	therapy	NOUN
ajst-25617	122	12	protocols	protocol	NOUN
ajst-25617	122	13	are	be	AUX
ajst-25617	122	14	also	also	ADV
ajst-25617	122	15	being	be	AUX
ajst-25617	122	16	tried	try	VERB
ajst-25617	122	17	.	.	PUNCT
ajst-25617	123	1	currently	currently	ADV
ajst-25617	123	2	,	,	PUNCT
ajst-25617	123	3	there	there	PRON
ajst-25617	123	4	are	be	VERB
ajst-25617	123	5	over	over	ADP
ajst-25617	123	6	5000	5000	NUM
ajst-25617	123	7	ongoing	ongoing	ADJ
ajst-25617	123	8	clinical	clinical	ADJ
ajst-25617	123	9	trials	trial	NOUN
ajst-25617	123	10	globally	globally	ADV
ajst-25617	123	11	on	on	ADP
ajst-25617	123	12	the	the	DET
ajst-25617	123	13	combined	combine	VERB
ajst-25617	123	14	use	use	NOUN
ajst-25617	123	15	of	of	ADP
ajst-25617	123	16	pd-1	pd-1	NOUN
ajst-25617	123	17	/	/	SYM
ajst-25617	123	18	pd	pd	ADJ
ajst-25617	123	19	-	-	PUNCT
ajst-25617	123	20	l1	l1	PROPN
ajst-25617	123	21	inhibitors	inhibitor	NOUN
ajst-25617	123	22	,	,	PUNCT
ajst-25617	123	23	covering	cover	VERB
ajst-25617	123	24	almost	almost	ADV
ajst-25617	123	25	all	all	PRON
ajst-25617	123	26	malignancies	malignancy	NOUN
ajst-25617	123	27	.	.	PUNCT
ajst-25617	124	1	secondly	secondly	ADV
ajst-25617	124	2	,	,	PUNCT
ajst-25617	124	3	the	the	DET
ajst-25617	124	4	metabolic	metabolic	NOUN
ajst-25617	124	5	regulation	regulation	NOUN
ajst-25617	124	6	of	of	ADP
ajst-25617	124	7	immune	immune	ADJ
ajst-25617	124	8	cells	cell	NOUN
ajst-25617	124	9	by	by	ADP
ajst-25617	124	10	the	the	DET
ajst-25617	124	11	three	three	NUM
ajst-25617	124	12	major	major	ADJ
ajst-25617	124	13	nutrients	nutrient	NOUN
ajst-25617	124	14	mediated	mediate	VERB
ajst-25617	124	15	by	by	ADP
ajst-25617	124	16	slcs	slcs	NOUN
ajst-25617	124	17	and	and	CCONJ
ajst-25617	124	18	some	some	DET
ajst-25617	124	19	potential	potential	ADJ
ajst-25617	124	20	strategies	strategy	NOUN
ajst-25617	124	21	for	for	ADP
ajst-25617	124	22	targeting	target	VERB
ajst-25617	124	23	slcs	slcs	NOUN
ajst-25617	124	24	on	on	ADP
ajst-25617	124	25	immune	immune	ADJ
ajst-25617	124	26	cells	cell	NOUN
ajst-25617	124	27	to	to	PART
ajst-25617	124	28	enhance	enhance	VERB
ajst-25617	124	29	tumor	tumor	NOUN
ajst-25617	124	30	immunotherapy	immunotherapy	NOUN
ajst-25617	124	31	.	.	PUNCT
ajst-25617	125	1	thirdly	thirdly	ADV
ajst-25617	125	2	,	,	PUNCT
ajst-25617	125	3	the	the	DET
ajst-25617	125	4	biological	biological	ADJ
ajst-25617	125	5	function	function	NOUN
ajst-25617	125	6	of	of	ADP
ajst-25617	125	7	soluble	soluble	ADJ
ajst-25617	125	8	t	t	NOUN
ajst-25617	125	9	cell	cell	NOUN
ajst-25617	125	10	immunoglobulin	immunoglobulin	NOUN
ajst-25617	125	11	and	and	CCONJ
ajst-25617	125	12	mucin	mucin	NOUN
ajst-25617	125	13	domain	domain	NOUN
ajst-25617	125	14	3	3	NUM
ajst-25617	125	15	(	(	PUNCT
ajst-25617	125	16	stim3	stim3	PROPN
ajst-25617	125	17	)	)	PUNCT
ajst-25617	125	18	and	and	CCONJ
ajst-25617	125	19	its	its	PRON
ajst-25617	125	20	important	important	ADJ
ajst-25617	125	21	role	role	NOUN
ajst-25617	125	22	in	in	ADP
ajst-25617	125	23	tumor	tumor	NOUN
ajst-25617	125	24	immunotherapy	immunotherapy	NOUN
ajst-25617	125	25	.	.	PUNCT
ajst-25617	126	1	the	the	DET
ajst-25617	126	2	level	level	NOUN
ajst-25617	126	3	of	of	ADP
ajst-25617	126	4	stim3	stim3	NOUN
ajst-25617	126	5	in	in	ADP
ajst-25617	126	6	the	the	DET
ajst-25617	126	7	plasma	plasma	NOUN
ajst-25617	126	8	of	of	ADP
ajst-25617	126	9	patients	patient	NOUN
ajst-25617	126	10	with	with	ADP
ajst-25617	126	11	various	various	ADJ
ajst-25617	126	12	diseases	disease	NOUN
ajst-25617	126	13	is	be	AUX
ajst-25617	126	14	abnormal	abnormal	ADJ
ajst-25617	126	15	,	,	PUNCT
ajst-25617	126	16	especially	especially	ADV
ajst-25617	126	17	in	in	ADP
ajst-25617	126	18	cancer	cancer	NOUN
ajst-25617	126	19	patients	patient	NOUN
ajst-25617	126	20	.	.	PUNCT
ajst-25617	127	1	future	future	ADJ
ajst-25617	127	2	research	research	NOUN
ajst-25617	127	3	can	can	AUX
ajst-25617	127	4	explore	explore	VERB
ajst-25617	127	5	the	the	DET
ajst-25617	127	6	potential	potential	NOUN
ajst-25617	127	7	of	of	ADP
ajst-25617	127	8	stim3	stim3	NOUN
ajst-25617	127	9	as	as	ADP
ajst-25617	127	10	an	an	DET
ajst-25617	127	11	immunotherapy	immunotherapy	NOUN
ajst-25617	127	12	target	target	NOUN
ajst-25617	127	13	.	.	PUNCT
ajst-25617	128	1	fourthly	fourthly	ADV
ajst-25617	128	2	,	,	PUNCT
ajst-25617	128	3	macrophages	macrophage	NOUN
ajst-25617	128	4	are	be	AUX
ajst-25617	128	5	key	key	ADJ
ajst-25617	128	6	members	member	NOUN
ajst-25617	128	7	of	of	ADP
ajst-25617	128	8	the	the	DET
ajst-25617	128	9	immune	immune	ADJ
ajst-25617	128	10	system	system	NOUN
ajst-25617	128	11	with	with	ADP
ajst-25617	128	12	powerful	powerful	ADJ
ajst-25617	128	13	phagocytic	phagocytic	ADJ
ajst-25617	128	14	and	and	CCONJ
ajst-25617	128	15	digestive	digestive	ADJ
ajst-25617	128	16	functions	function	NOUN
ajst-25617	128	17	.	.	PUNCT
ajst-25617	129	1	utilizing	utilize	VERB
ajst-25617	129	2	chimeric	chimeric	ADJ
ajst-25617	129	3	antigen	antigen	ADJ
ajst-25617	129	4	receptor	receptor	NOUN
ajst-25617	129	5	(	(	PUNCT
ajst-25617	129	6	car	car	NOUN
ajst-25617	129	7	)	)	PUNCT
ajst-25617	129	8	technology	technology	NOUN
ajst-25617	129	9	,	,	PUNCT
ajst-25617	129	10	macrophages	macrophage	NOUN
ajst-25617	129	11	undergo	undergo	VERB
ajst-25617	129	12	genetic	genetic	ADJ
ajst-25617	129	13	modifications	modification	NOUN
ajst-25617	129	14	that	that	PRON
ajst-25617	129	15	empower	empower	VERB
ajst-25617	129	16	them	they	PRON
ajst-25617	129	17	with	with	ADP
ajst-25617	129	18	the	the	DET
ajst-25617	129	19	ability	ability	NOUN
ajst-25617	129	20	to	to	PART
ajst-25617	129	21	uniquely	uniquely	ADV
ajst-25617	129	22	identify	identify	VERB
ajst-25617	129	23	and	and	CCONJ
ajst-25617	129	24	recognize	recognize	VERB
ajst-25617	129	25	antigens	antigen	NOUN
ajst-25617	129	26	expressed	express	VERB
ajst-25617	129	27	on	on	ADP
ajst-25617	129	28	the	the	DET
ajst-25617	129	29	exterior	exterior	NOUN
ajst-25617	129	30	of	of	ADP
ajst-25617	129	31	tumor	tumor	NOUN
ajst-25617	129	32	cells	cell	NOUN
ajst-25617	129	33	,	,	PUNCT
ajst-25617	129	34	combining	combine	VERB
ajst-25617	129	35	the	the	DET
ajst-25617	129	36	natural	natural	ADJ
ajst-25617	129	37	immune	immune	ADJ
ajst-25617	129	38	function	function	NOUN
ajst-25617	129	39	of	of	ADP
ajst-25617	129	40	macrophages	macrophage	NOUN
ajst-25617	129	41	with	with	ADP
ajst-25617	129	42	the	the	DET
ajst-25617	129	43	high	high	ADJ
ajst-25617	129	44	specificity	specificity	NOUN
ajst-25617	129	45	of	of	ADP
ajst-25617	129	46	car	car	NOUN
ajst-25617	129	47	to	to	PART
ajst-25617	129	48	enhance	enhance	VERB
ajst-25617	129	49	their	their	PRON
ajst-25617	129	50	targeting	targeting	NOUN
ajst-25617	129	51	and	and	CCONJ
ajst-25617	129	52	killing	kill	VERB
ajst-25617	129	53	abilities	ability	NOUN
ajst-25617	129	54	against	against	ADP
ajst-25617	129	55	tumors	tumor	NOUN
ajst-25617	129	56	,	,	PUNCT
ajst-25617	129	57	achieving	achieve	VERB
ajst-25617	129	58	effective	effective	ADJ
ajst-25617	129	59	immunotherapy	immunotherapy	NOUN
ajst-25617	129	60	.	.	PUNCT
ajst-25617	130	1	macrophages	macrophage	NOUN
ajst-25617	130	2	with	with	ADP
ajst-25617	130	3	cars	car	NOUN
ajst-25617	130	4	(	(	PUNCT
ajst-25617	130	5	car	car	NOUN
ajst-25617	130	6	-	-	PUNCT
ajst-25617	130	7	ms	ms	NOUN
ajst-25617	130	8	)	)	PUNCT
ajst-25617	130	9	can	can	AUX
ajst-25617	130	10	stimulate	stimulate	VERB
ajst-25617	130	11	tumor	tumor	NOUN
ajst-25617	130	12	phagocytic	phagocytic	ADJ
ajst-25617	130	13	function	function	NOUN
ajst-25617	130	14	transduction	transduction	NOUN
ajst-25617	130	15	and	and	CCONJ
ajst-25617	130	16	induce	induce	VERB
ajst-25617	130	17	car	car	NOUN
ajst-25617	130	18	-	-	PUNCT
ajst-25617	130	19	ms	ms	NOUN
ajst-25617	130	20	to	to	PART
ajst-25617	130	21	exhibit	exhibit	VERB
ajst-25617	130	22	an	an	DET
ajst-25617	130	23	m1	m1	NOUN
ajst-25617	130	24	-	-	PUNCT
ajst-25617	130	25	type	type	NOUN
ajst-25617	130	26	phenotype	phenotype	NOUN
ajst-25617	130	27	by	by	ADP
ajst-25617	130	28	recombining	recombine	VERB
ajst-25617	130	29	cars	car	NOUN
ajst-25617	130	30	of	of	ADP
ajst-25617	130	31	human	human	ADJ
ajst-25617	130	32	macrophages	macrophage	NOUN
ajst-25617	130	33	,	,	PUNCT
ajst-25617	130	34	secreting	secrete	VERB
ajst-25617	130	35	proinflammatory	proinflammatory	ADJ
ajst-25617	130	36	cytokines	cytokine	NOUN
ajst-25617	130	37	to	to	PART
ajst-25617	130	38	repolarize	repolarize	VERB
ajst-25617	130	39	m2	m2	PROPN
ajst-25617	130	40	macrophages	macrophage	NOUN
ajst-25617	130	41	in	in	ADP
ajst-25617	130	42	the	the	DET
ajst-25617	130	43	tme	tme	NOUN
ajst-25617	130	44	and	and	CCONJ
ajst-25617	130	45	promote	promote	VERB
ajst-25617	130	46	immune	immune	ADJ
ajst-25617	130	47	responses	response	NOUN
ajst-25617	130	48	of	of	ADP
ajst-25617	130	49	t	t	NOUN
ajst-25617	130	50	cells	cell	NOUN
ajst-25617	130	51	.	.	PUNCT
ajst-25617	131	1	5	5	X
ajst-25617	131	2	.	.	X
ajst-25617	131	3	conclusion	conclusion	NOUN
ajst-25617	131	4	cell	cell	NOUN
ajst-25617	131	5	-	-	PUNCT
ajst-25617	131	6	based	base	VERB
ajst-25617	131	7	immunotherapy	immunotherapy	NOUN
ajst-25617	131	8	harnesses	harness	NOUN
ajst-25617	131	9	the	the	DET
ajst-25617	131	10	body	body	NOUN
ajst-25617	131	11	's	's	PART
ajst-25617	131	12	inherent	inherent	ADJ
ajst-25617	131	13	immune	immune	ADJ
ajst-25617	131	14	capabilities	capability	NOUN
ajst-25617	131	15	to	to	PART
ajst-25617	131	16	identify	identify	VERB
ajst-25617	131	17	and	and	CCONJ
ajst-25617	131	18	combat	combat	VERB
ajst-25617	131	19	cancerous	cancerous	ADJ
ajst-25617	131	20	cells	cell	NOUN
ajst-25617	131	21	,	,	PUNCT
ajst-25617	131	22	offering	offer	VERB
ajst-25617	131	23	a	a	DET
ajst-25617	131	24	novel	novel	ADJ
ajst-25617	131	25	therapeutic	therapeutic	ADJ
ajst-25617	131	26	approach	approach	NOUN
ajst-25617	131	27	.	.	PUNCT
ajst-25617	132	1	it	it	PRON
ajst-25617	132	2	holds	hold	VERB
ajst-25617	132	3	significant	significant	ADJ
ajst-25617	132	4	importance	importance	NOUN
ajst-25617	132	5	and	and	CCONJ
ajst-25617	132	6	immense	immense	ADJ
ajst-25617	132	7	potential	potential	NOUN
ajst-25617	132	8	in	in	ADP
ajst-25617	132	9	the	the	DET
ajst-25617	132	10	field	field	NOUN
ajst-25617	132	11	of	of	ADP
ajst-25617	132	12	cancer	cancer	NOUN
ajst-25617	132	13	treatment	treatment	NOUN
ajst-25617	132	14	.	.	PUNCT
ajst-25617	133	1	by	by	ADP
ajst-25617	133	2	activating	activate	VERB
ajst-25617	133	3	and	and	CCONJ
ajst-25617	133	4	enhancing	enhance	VERB
ajst-25617	133	5	the	the	DET
ajst-25617	133	6	patient	patient	NOUN
ajst-25617	133	7	's	's	PART
ajst-25617	133	8	own	own	ADJ
ajst-25617	133	9	immune	immune	ADJ
ajst-25617	133	10	cells	cell	NOUN
ajst-25617	133	11	,	,	PUNCT
ajst-25617	133	12	cell	cell	NOUN
ajst-25617	133	13	immunotherapy	immunotherapy	NOUN
ajst-25617	133	14	can	can	AUX
ajst-25617	133	15	not	not	PART
ajst-25617	133	16	only	only	ADV
ajst-25617	133	17	extend	extend	VERB
ajst-25617	133	18	the	the	DET
ajst-25617	133	19	survival	survival	NOUN
ajst-25617	133	20	period	period	NOUN
ajst-25617	133	21	of	of	ADP
ajst-25617	133	22	cancer	cancer	NOUN
ajst-25617	133	23	patients	patient	NOUN
ajst-25617	133	24	but	but	CCONJ
ajst-25617	133	25	also	also	ADV
ajst-25617	133	26	significantly	significantly	ADV
ajst-25617	133	27	improve	improve	VERB
ajst-25617	133	28	their	their	PRON
ajst-25617	133	29	quality	quality	NOUN
ajst-25617	133	30	of	of	ADP
ajst-25617	133	31	life	life	NOUN
ajst-25617	133	32	.	.	PUNCT
ajst-25617	134	1	firstly	firstly	ADV
ajst-25617	134	2	,	,	PUNCT
ajst-25617	134	3	cell	cell	NOUN
ajst-25617	134	4	immunotherapy	immunotherapy	NOUN
ajst-25617	134	5	targets	target	VERB
ajst-25617	134	6	specific	specific	ADJ
ajst-25617	134	7	tumor	tumor	NOUN
ajst-25617	134	8	antigens	antigen	NOUN
ajst-25617	134	9	to	to	AUX
ajst-25617	134	10	precisely	precisely	ADV
ajst-25617	134	11	attack	attack	VERB
ajst-25617	134	12	cancer	cancer	NOUN
ajst-25617	134	13	cells	cell	NOUN
ajst-25617	134	14	,	,	PUNCT
ajst-25617	134	15	minimizing	minimize	VERB
ajst-25617	134	16	damage	damage	NOUN
ajst-25617	134	17	to	to	ADP
ajst-25617	134	18	normal	normal	ADJ
ajst-25617	134	19	cells	cell	NOUN
ajst-25617	134	20	.	.	PUNCT
ajst-25617	135	1	compared	compare	VERB
ajst-25617	135	2	to	to	ADP
ajst-25617	135	3	traditional	traditional	ADJ
ajst-25617	135	4	radiotherapy	radiotherapy	NOUN
ajst-25617	135	5	and	and	CCONJ
ajst-25617	135	6	chemotherapy	chemotherapy	NOUN
ajst-25617	135	7	,	,	PUNCT
ajst-25617	135	8	this	this	DET
ajst-25617	135	9	method	method	NOUN
ajst-25617	135	10	has	have	VERB
ajst-25617	135	11	fewer	few	ADJ
ajst-25617	135	12	side	side	NOUN
ajst-25617	135	13	effects	effect	NOUN
ajst-25617	135	14	,	,	PUNCT
ajst-25617	135	15	reducing	reduce	VERB
ajst-25617	135	16	the	the	DET
ajst-25617	135	17	physical	physical	ADJ
ajst-25617	135	18	burden	burden	NOUN
ajst-25617	135	19	on	on	ADP
ajst-25617	135	20	patients	patient	NOUN
ajst-25617	135	21	and	and	CCONJ
ajst-25617	135	22	improving	improve	VERB
ajst-25617	135	23	their	their	PRON
ajst-25617	135	24	quality	quality	NOUN
ajst-25617	135	25	of	of	ADP
ajst-25617	135	26	life	life	NOUN
ajst-25617	135	27	.	.	PUNCT
ajst-25617	136	1	secondly	secondly	ADV
ajst-25617	136	2	,	,	PUNCT
ajst-25617	136	3	cell	cell	NOUN
ajst-25617	136	4	immunotherapy	immunotherapy	NOUN
ajst-25617	136	5	can	can	AUX
ajst-25617	136	6	activate	activate	VERB
ajst-25617	136	7	immune	immune	ADJ
ajst-25617	136	8	memory	memory	NOUN
ajst-25617	136	9	within	within	ADP
ajst-25617	136	10	the	the	DET
ajst-25617	136	11	patient	patient	NOUN
ajst-25617	136	12	's	's	PART
ajst-25617	136	13	body	body	NOUN
ajst-25617	136	14	,	,	PUNCT
ajst-25617	136	15	enabling	enable	VERB
ajst-25617	136	16	the	the	DET
ajst-25617	136	17	immune	immune	ADJ
ajst-25617	136	18	system	system	NOUN
ajst-25617	136	19	to	to	PART
ajst-25617	136	20	continuously	continuously	ADV
ajst-25617	136	21	monitor	monitor	VERB
ajst-25617	136	22	and	and	CCONJ
ajst-25617	136	23	eliminate	eliminate	VERB
ajst-25617	136	24	cancer	cancer	NOUN
ajst-25617	136	25	cells	cell	NOUN
ajst-25617	136	26	,	,	PUNCT
ajst-25617	136	27	potentially	potentially	ADV
ajst-25617	136	28	leading	lead	VERB
ajst-25617	136	29	to	to	ADP
ajst-25617	136	30	long	long	ADJ
ajst-25617	136	31	-	-	PUNCT
ajst-25617	136	32	term	term	NOUN
ajst-25617	136	33	disease	disease	NOUN
ajst-25617	136	34	control	control	NOUN
ajst-25617	136	35	or	or	CCONJ
ajst-25617	136	36	even	even	ADV
ajst-25617	136	37	cure	cure	VERB
ajst-25617	136	38	.	.	PUNCT
ajst-25617	137	1	for	for	ADP
ajst-25617	137	2	patients	patient	NOUN
ajst-25617	137	3	with	with	ADP
ajst-25617	137	4	advanced	advanced	ADJ
ajst-25617	137	5	cancer	cancer	NOUN
ajst-25617	137	6	,	,	PUNCT
ajst-25617	137	7	this	this	PRON
ajst-25617	137	8	represents	represent	VERB
ajst-25617	137	9	greater	great	ADJ
ajst-25617	137	10	hope	hope	NOUN
ajst-25617	137	11	and	and	CCONJ
ajst-25617	137	12	a	a	DET
ajst-25617	137	13	better	well	ADJ
ajst-25617	137	14	prognosis	prognosis	NOUN
ajst-25617	137	15	.	.	PUNCT
ajst-25617	138	1	additionally	additionally	ADV
ajst-25617	138	2	,	,	PUNCT
ajst-25617	138	3	as	as	SCONJ
ajst-25617	138	4	scientific	scientific	ADJ
ajst-25617	138	5	research	research	NOUN
ajst-25617	138	6	continues	continue	VERB
ajst-25617	138	7	to	to	PART
ajst-25617	138	8	advance	advance	VERB
ajst-25617	138	9	,	,	PUNCT
ajst-25617	138	10	methods	method	NOUN
ajst-25617	138	11	of	of	ADP
ajst-25617	138	12	cell	cell	NOUN
ajst-25617	138	13	immunotherapy	immunotherapy	NOUN
ajst-25617	138	14	are	be	AUX
ajst-25617	138	15	constantly	constantly	ADV
ajst-25617	138	16	being	be	AUX
ajst-25617	138	17	optimized	optimize	VERB
ajst-25617	138	18	and	and	CCONJ
ajst-25617	138	19	innovated	innovate	VERB
ajst-25617	138	20	.	.	PUNCT
ajst-25617	139	1	for	for	ADP
ajst-25617	139	2	instance	instance	NOUN
ajst-25617	139	3	,	,	PUNCT
ajst-25617	139	4	car	car	NOUN
ajst-25617	139	5	-	-	PUNCT
ajst-25617	139	6	t	t	NOUN
ajst-25617	139	7	cell	cell	NOUN
ajst-25617	139	8	therapy	therapy	NOUN
ajst-25617	139	9	has	have	AUX
ajst-25617	139	10	achieved	achieve	VERB
ajst-25617	139	11	remarkable	remarkable	ADJ
ajst-25617	139	12	therapeutic	therapeutic	ADJ
ajst-25617	139	13	effects	effect	NOUN
ajst-25617	139	14	in	in	ADP
ajst-25617	139	15	certain	certain	ADJ
ajst-25617	139	16	types	type	NOUN
ajst-25617	139	17	of	of	ADP
ajst-25617	139	18	hematologic	hematologic	NOUN
ajst-25617	139	19	malignancies	malignancy	NOUN
ajst-25617	139	20	,	,	PUNCT
ajst-25617	139	21	while	while	SCONJ
ajst-25617	139	22	strategies	strategy	NOUN
ajst-25617	139	23	for	for	ADP
ajst-25617	139	24	cell	cell	NOUN
ajst-25617	139	25	immunotherapy	immunotherapy	NOUN
ajst-25617	139	26	against	against	ADP
ajst-25617	139	27	solid	solid	ADJ
ajst-25617	139	28	tumors	tumor	NOUN
ajst-25617	139	29	are	be	AUX
ajst-25617	139	30	also	also	ADV
ajst-25617	139	31	being	be	AUX
ajst-25617	139	32	actively	actively	ADV
ajst-25617	139	33	explored	explore	VERB
ajst-25617	139	34	and	and	CCONJ
ajst-25617	139	35	developed	develop	VERB
ajst-25617	139	36	.	.	PUNCT
ajst-25617	140	1	in	in	ADP
ajst-25617	140	2	summary	summary	NOUN
ajst-25617	140	3	,	,	PUNCT
ajst-25617	140	4	cell	cell	NOUN
ajst-25617	140	5	immunotherapy	immunotherapy	NOUN
ajst-25617	140	6	provides	provide	VERB
ajst-25617	140	7	a	a	DET
ajst-25617	140	8	novel	novel	ADJ
ajst-25617	140	9	treatment	treatment	NOUN
ajst-25617	140	10	option	option	NOUN
ajst-25617	140	11	for	for	ADP
ajst-25617	140	12	cancer	cancer	NOUN
ajst-25617	140	13	patients	patient	NOUN
ajst-25617	140	14	,	,	PUNCT
ajst-25617	140	15	extending	extend	VERB
ajst-25617	140	16	their	their	PRON
ajst-25617	140	17	survival	survival	NOUN
ajst-25617	140	18	period	period	NOUN
ajst-25617	140	19	and	and	CCONJ
ajst-25617	140	20	improving	improve	VERB
ajst-25617	140	21	their	their	PRON
ajst-25617	140	22	quality	quality	NOUN
ajst-25617	140	23	of	of	ADP
ajst-25617	140	24	life	life	NOUN
ajst-25617	140	25	,	,	PUNCT
ajst-25617	140	26	bringing	bring	VERB
ajst-25617	140	27	revolutionary	revolutionary	ADJ
ajst-25617	140	28	changes	change	NOUN
ajst-25617	140	29	to	to	ADP
ajst-25617	140	30	cancer	cancer	NOUN
ajst-25617	140	31	treatment	treatment	NOUN
ajst-25617	140	32	.	.	PUNCT
ajst-25617	141	1	with	with	ADP
ajst-25617	141	2	continuous	continuous	ADJ
ajst-25617	141	3	progress	progress	NOUN
ajst-25617	141	4	in	in	ADP
ajst-25617	141	5	future	future	ADJ
ajst-25617	141	6	research	research	NOUN
ajst-25617	141	7	,	,	PUNCT
ajst-25617	141	8	cell	cell	NOUN
ajst-25617	141	9	immunotherapy	immunotherapy	NOUN
ajst-25617	141	10	is	be	AUX
ajst-25617	141	11	expected	expect	VERB
ajst-25617	141	12	to	to	PART
ajst-25617	141	13	play	play	VERB
ajst-25617	141	14	a	a	DET
ajst-25617	141	15	crucial	crucial	ADJ
ajst-25617	141	16	role	role	NOUN
ajst-25617	141	17	in	in	ADP
ajst-25617	141	18	the	the	DET
ajst-25617	141	19	treatment	treatment	NOUN
ajst-25617	141	20	of	of	ADP
ajst-25617	141	21	various	various	ADJ
ajst-25617	141	22	types	type	NOUN
ajst-25617	141	23	of	of	ADP
ajst-25617	141	24	cancer	cancer	NOUN
ajst-25617	141	25	,	,	PUNCT
ajst-25617	141	26	offering	offer	VERB
ajst-25617	141	27	patients	patient	NOUN
ajst-25617	141	28	greater	great	ADJ
ajst-25617	141	29	hope	hope	NOUN
ajst-25617	141	30	.	.	PUNCT
ajst-25617	142	1	references	reference	NOUN
ajst-25617	142	2	[	[	X
ajst-25617	142	3	1	1	NUM
ajst-25617	142	4	]	]	X
ajst-25617	142	5	maude	maude	PROPN
ajst-25617	142	6	,	,	PUNCT
ajst-25617	142	7	s.l	s.l	PROPN
ajst-25617	142	8	.	.	PROPN
ajst-25617	142	9	,	,	PUNCT
ajst-25617	142	10	et	et	PROPN
ajst-25617	142	11	al	al	PROPN
ajst-25617	142	12	.	.	PROPN
ajst-25617	142	13	,	,	PUNCT
ajst-25617	142	14	chimeric	chimeric	ADJ
ajst-25617	142	15	antigen	antigen	ADJ
ajst-25617	142	16	receptor	receptor	NOUN
ajst-25617	142	17	t	t	NOUN
ajst-25617	142	18	cells	cell	NOUN
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ajst-25617	142	20	sustained	sustained	ADJ
ajst-25617	142	21	remissions	remission	NOUN
ajst-25617	142	22	in	in	ADP
ajst-25617	142	23	leukemia	leukemia	NOUN
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ajst-25617	143	6	,	,	PUNCT
ajst-25617	143	7	2014	2014	NUM
ajst-25617	143	8	.	.	PUNCT
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ajst-25617	144	2	):	):	PUNCT
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ajst-25617	144	5	-	-	SYM
ajst-25617	144	6	1517	1517	NUM
ajst-25617	144	7	.	.	PUNCT
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ajst-25617	145	2	2	2	NUM
ajst-25617	145	3	]	]	X
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ajst-25617	145	5	,	,	PUNCT
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ajst-25617	145	16	t	t	NOUN
ajst-25617	145	17	cells	cell	NOUN
ajst-25617	145	18	persisting	persist	VERB
ajst-25617	145	19	and	and	CCONJ
ajst-25617	145	20	mediating	mediate	VERB
ajst-25617	145	21	sustained	sustained	ADJ
ajst-25617	145	22	remissions	remission	NOUN
ajst-25617	145	23	in	in	ADP
ajst-25617	145	24	multiple	multiple	ADJ
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ajst-25617	146	6	,	,	PUNCT
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ajst-25617	146	8	.	.	PUNCT
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ajst-25617	147	2	):	):	PUNCT
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ajst-25617	147	5	-	-	SYM
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ajst-25617	147	7	.	.	PUNCT
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ajst-25617	148	3	]	]	X
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ajst-25617	148	8	,	,	PUNCT
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ajst-25617	148	18	in	in	ADP
ajst-25617	148	19	refractory	refractory	PROPN
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ajst-25617	148	21	-	-	PUNCT
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ajst-25617	148	28	.	.	PUNCT
ajst-25617	149	1	new	new	PROPN
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ajst-25617	149	6	,	,	PUNCT
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ajst-25617	149	8	.	.	PUNCT
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ajst-25617	150	2	):	):	PUNCT
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ajst-25617	150	5	-	-	SYM
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ajst-25617	150	7	.	.	PUNCT
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ajst-25617	151	2	4	4	NUM
ajst-25617	151	3	]	]	X
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ajst-25617	151	5	,	,	PUNCT
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ajst-25617	151	8	,	,	PUNCT
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ajst-25617	151	16	management	management	NOUN
ajst-25617	151	17	of	of	ADP
ajst-25617	151	18	1928z	1928z	NUM
ajst-25617	151	19	car	car	NOUN
ajst-25617	151	20	t	t	NOUN
ajst-25617	151	21	cell	cell	NOUN
ajst-25617	151	22	therapy	therapy	NOUN
ajst-25617	151	23	in	in	ADP
ajst-25617	151	24	b	b	PROPN
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ajst-25617	151	26	acute	acute	NOUN
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ajst-25617	151	29	.	.	PUNCT
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ajst-25617	152	3	medicine	medicine	NOUN
ajst-25617	152	4	,	,	PUNCT
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ajst-25617	152	6	.	.	PUNCT
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ajst-25617	153	2	):	):	PUNCT
ajst-25617	153	3	p.	p.	NOUN
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ajst-25617	153	5	.	.	PUNCT
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ajst-25617	154	3	]	]	X
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ajst-25617	154	5	,	,	PUNCT
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ajst-25617	154	11	,	,	PUNCT
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ajst-25617	154	20	of	of	ADP
ajst-25617	154	21	b	b	NOUN
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ajst-25617	154	24	.	.	PUNCT
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ajst-25617	155	2	,	,	PUNCT
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ajst-25617	155	4	.	.	PUNCT
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ajst-25617	156	5	-	-	SYM
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ajst-25617	156	7	.	.	PUNCT
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ajst-25617	157	4	]	]	PUNCT
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ajst-25617	157	28	.	.	PUNCT
ajst-25617	158	1	j	j	PROPN
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ajst-25617	158	4	,	,	PUNCT
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ajst-25617	159	2	):	):	PUNCT
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ajst-25617	159	5	-	-	SYM
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ajst-25617	159	7	.	.	PUNCT
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ajst-25617	160	3	]	]	X
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ajst-25617	160	5	,	,	PUNCT
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ajst-25617	161	5	.	.	PUNCT
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ajst-25617	162	2	):	):	PUNCT
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ajst-25617	162	5	-	-	SYM
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ajst-25617	162	7	.	.	PUNCT
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ajst-25617	163	21	escape	escape	NOUN
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ajst-25617	163	25	.	.	PUNCT
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ajst-25617	164	3	,	,	PUNCT
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ajst-25617	164	5	.	.	PUNCT
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ajst-25617	165	2	):	):	PUNCT
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ajst-25617	165	5	-	-	SYM
ajst-25617	165	6	1058	1058	NUM
ajst-25617	165	7	.	.	PUNCT
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ajst-25617	166	12	,	,	PUNCT
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ajst-25617	166	14	t	t	NOUN
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ajst-25617	166	22	receptor	receptor	NOUN
ajst-25617	166	23	(	(	PUNCT
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ajst-25617	168	5	.	.	PUNCT
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ajst-25617	169	3	]	]	SYM
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ajst-25617	170	2	,	,	PUNCT
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ajst-25617	170	4	.	.	PUNCT
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ajst-25617	171	5	-	-	SYM
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