id	sid	tid	token	lemma	pos
ajst-28606	1	1	academic	academic	ADJ
ajst-28606	1	2	journal	journal	NOUN
ajst-28606	1	3	of	of	ADP
ajst-28606	1	4	science	science	NOUN
ajst-28606	1	5	and	and	CCONJ
ajst-28606	1	6	technology	technology	NOUN
ajst-28606	1	7	issn	issn	NOUN
ajst-28606	1	8	:	:	PUNCT
ajst-28606	1	9	2771	2771	NUM
ajst-28606	1	10	-	-	SYM
ajst-28606	1	11	3032	3032	NUM
ajst-28606	1	12	|	|	NOUN
ajst-28606	1	13	vol	vol	NOUN
ajst-28606	1	14	.	.	PROPN
ajst-28606	1	15	13	13	NUM
ajst-28606	1	16	,	,	PUNCT
ajst-28606	1	17	no	no	INTJ
ajst-28606	1	18	.	.	NOUN
ajst-28606	1	19	3	3	NUM
ajst-28606	1	20	,	,	PUNCT
ajst-28606	1	21	2024	2024	NUM
ajst-28606	1	22	132	132	NUM
ajst-28606	1	23	a	a	DET
ajst-28606	1	24	review	review	NOUN
ajst-28606	1	25	of	of	ADP
ajst-28606	1	26	research	research	NOUN
ajst-28606	1	27	on	on	ADP
ajst-28606	1	28	crispr	crispr	ADJ
ajst-28606	1	29	/	/	SYM
ajst-28606	1	30	cas9	cas9	NOUN
ajst-28606	1	31	gene	gene	NOUN
ajst-28606	1	32	editing	edit	VERB
ajst-28606	1	33	technology	technology	NOUN
ajst-28606	1	34	in	in	ADP
ajst-28606	1	35	disease	disease	NOUN
ajst-28606	1	36	treatment	treatment	NOUN
ajst-28606	1	37	xiao	xiao	PROPN
ajst-28606	1	38	jing1	jing1	PROPN
ajst-28606	1	39	,	,	PUNCT
ajst-28606	1	40	*	*	PROPN
ajst-28606	1	41	1department	1department	NUM
ajst-28606	1	42	of	of	ADP
ajst-28606	1	43	bioprocess	bioprocess	NOUN
ajst-28606	1	44	engineering	engineering	NOUN
ajst-28606	1	45	,	,	PUNCT
ajst-28606	1	46	beijing	beijing	PROPN
ajst-28606	1	47	university	university	PROPN
ajst-28606	1	48	of	of	ADP
ajst-28606	1	49	chemical	chemical	PROPN
ajst-28606	1	50	technology	technology	PROPN
ajst-28606	1	51	,	,	PUNCT
ajst-28606	1	52	beijing	beijing	PROPN
ajst-28606	1	53	,	,	PUNCT
ajst-28606	1	54	china	china	PROPN
ajst-28606	1	55	*	*	PUNCT
ajst-28606	1	56	corresponding	correspond	VERB
ajst-28606	1	57	author	author	NOUN
ajst-28606	1	58	email	email	NOUN
ajst-28606	1	59	:	:	PUNCT
ajst-28606	2	1	xjing02@syr.edu	xjing02@syr.edu	PROPN
ajst-28606	2	2	abstract	abstract	PROPN
ajst-28606	2	3	:	:	PUNCT
ajst-28606	2	4	the	the	DET
ajst-28606	2	5	appearance	appearance	NOUN
ajst-28606	2	6	of	of	ADP
ajst-28606	2	7	crispr	crispr	ADJ
ajst-28606	2	8	/	/	SYM
ajst-28606	2	9	cas9	cas9	NOUN
ajst-28606	2	10	gene	gene	NOUN
ajst-28606	2	11	editing	edit	VERB
ajst-28606	2	12	technology	technology	NOUN
ajst-28606	2	13	marks	mark	VERB
ajst-28606	2	14	a	a	DET
ajst-28606	2	15	revolutionary	revolutionary	ADJ
ajst-28606	2	16	advance	advance	NOUN
ajst-28606	2	17	in	in	ADP
ajst-28606	2	18	the	the	DET
ajst-28606	2	19	field	field	NOUN
ajst-28606	2	20	of	of	ADP
ajst-28606	2	21	gene	gene	NOUN
ajst-28606	2	22	editing	editing	NOUN
ajst-28606	2	23	.	.	PUNCT
ajst-28606	3	1	with	with	ADP
ajst-28606	3	2	its	its	PRON
ajst-28606	3	3	high	high	ADJ
ajst-28606	3	4	degree	degree	NOUN
ajst-28606	3	5	of	of	ADP
ajst-28606	3	6	specificity	specificity	NOUN
ajst-28606	3	7	and	and	CCONJ
ajst-28606	3	8	efficiency	efficiency	NOUN
ajst-28606	3	9	,	,	PUNCT
ajst-28606	3	10	this	this	DET
ajst-28606	3	11	technology	technology	NOUN
ajst-28606	3	12	enables	enable	VERB
ajst-28606	3	13	precise	precise	ADJ
ajst-28606	3	14	modification	modification	NOUN
ajst-28606	3	15	of	of	ADP
ajst-28606	3	16	genome	genome	NOUN
ajst-28606	3	17	-	-	PUNCT
ajst-28606	3	18	specific	specific	ADJ
ajst-28606	3	19	loci	loci	NOUN
ajst-28606	3	20	.	.	PUNCT
ajst-28606	4	1	this	this	DET
ajst-28606	4	2	paper	paper	NOUN
ajst-28606	4	3	reviews	review	VERB
ajst-28606	4	4	the	the	DET
ajst-28606	4	5	mechanism	mechanism	NOUN
ajst-28606	4	6	of	of	ADP
ajst-28606	4	7	crispr	crispr	ADJ
ajst-28606	4	8	/	/	SYM
ajst-28606	4	9	cas9	cas9	NOUN
ajst-28606	4	10	and	and	CCONJ
ajst-28606	4	11	its	its	PRON
ajst-28606	4	12	applications	application	NOUN
ajst-28606	4	13	in	in	ADP
ajst-28606	4	14	various	various	ADJ
ajst-28606	4	15	fields	field	NOUN
ajst-28606	4	16	such	such	ADJ
ajst-28606	4	17	as	as	ADP
ajst-28606	4	18	genetic	genetic	ADJ
ajst-28606	4	19	disease	disease	NOUN
ajst-28606	4	20	treatment	treatment	NOUN
ajst-28606	4	21	,	,	PUNCT
ajst-28606	4	22	cancer	cancer	NOUN
ajst-28606	4	23	therapy	therapy	NOUN
ajst-28606	4	24	,	,	PUNCT
ajst-28606	4	25	antiviral	antiviral	ADJ
ajst-28606	4	26	therapy	therapy	NOUN
ajst-28606	4	27	,	,	PUNCT
ajst-28606	4	28	gene	gene	NOUN
ajst-28606	4	29	function	function	NOUN
ajst-28606	4	30	research	research	NOUN
ajst-28606	4	31	and	and	CCONJ
ajst-28606	4	32	virus	virus	NOUN
ajst-28606	4	33	detection	detection	NOUN
ajst-28606	4	34	.	.	PUNCT
ajst-28606	5	1	also	also	ADV
ajst-28606	5	2	,	,	PUNCT
ajst-28606	5	3	the	the	DET
ajst-28606	5	4	challenges	challenge	NOUN
ajst-28606	5	5	of	of	ADP
ajst-28606	5	6	off	off	ADP
ajst-28606	5	7	-	-	PUNCT
ajst-28606	5	8	target	target	NOUN
ajst-28606	5	9	effects	effect	NOUN
ajst-28606	5	10	are	be	AUX
ajst-28606	5	11	discussed	discuss	VERB
ajst-28606	5	12	and	and	CCONJ
ajst-28606	5	13	strategies	strategy	NOUN
ajst-28606	5	14	to	to	PART
ajst-28606	5	15	minimize	minimize	VERB
ajst-28606	5	16	them	they	PRON
ajst-28606	5	17	are	be	AUX
ajst-28606	5	18	proposed	propose	VERB
ajst-28606	5	19	,	,	PUNCT
ajst-28606	5	20	the	the	DET
ajst-28606	5	21	purpose	purpose	NOUN
ajst-28606	5	22	of	of	ADP
ajst-28606	5	23	this	this	DET
ajst-28606	5	24	study	study	NOUN
ajst-28606	5	25	is	be	AUX
ajst-28606	5	26	to	to	PART
ajst-28606	5	27	propose	propose	VERB
ajst-28606	5	28	applications	application	NOUN
ajst-28606	5	29	and	and	CCONJ
ajst-28606	5	30	innovations	innovation	NOUN
ajst-28606	5	31	of	of	ADP
ajst-28606	5	32	crispr	crispr	ADJ
ajst-28606	5	33	/	/	SYM
ajst-28606	5	34	cas9	cas9	NOUN
ajst-28606	5	35	technology	technology	NOUN
ajst-28606	5	36	in	in	ADP
ajst-28606	5	37	medical	medical	ADJ
ajst-28606	5	38	therapeutics	therapeutic	NOUN
ajst-28606	5	39	while	while	SCONJ
ajst-28606	5	40	addressing	address	VERB
ajst-28606	5	41	its	its	PRON
ajst-28606	5	42	current	current	ADJ
ajst-28606	5	43	limitations	limitation	NOUN
ajst-28606	5	44	.	.	PUNCT
ajst-28606	6	1	keywords	keyword	NOUN
ajst-28606	6	2	:	:	PUNCT
ajst-28606	6	3	crispr	crispr	ADJ
ajst-28606	6	4	/	/	SYM
ajst-28606	6	5	cas9	cas9	NOUN
ajst-28606	6	6	,	,	PUNCT
ajst-28606	6	7	disease	disease	NOUN
ajst-28606	6	8	treatment	treatment	NOUN
ajst-28606	6	9	,	,	PUNCT
ajst-28606	6	10	mechanism	mechanism	NOUN
ajst-28606	6	11	,	,	PUNCT
ajst-28606	6	12	challenges	challenge	NOUN
ajst-28606	6	13	.	.	PUNCT
ajst-28606	7	1	1	1	X
ajst-28606	7	2	.	.	X
ajst-28606	7	3	introduction	introduction	NOUN
ajst-28606	7	4	the	the	DET
ajst-28606	7	5	appearance	appearance	NOUN
ajst-28606	7	6	of	of	ADP
ajst-28606	7	7	crispr	crispr	NOUN
ajst-28606	7	8	/	/	SYM
ajst-28606	7	9	cas9	cas9	NOUN
ajst-28606	7	10	makes	make	VERB
ajst-28606	7	11	a	a	DET
ajst-28606	7	12	progress	progress	NOUN
ajst-28606	7	13	in	in	ADP
ajst-28606	7	14	the	the	DET
ajst-28606	7	15	field	field	NOUN
ajst-28606	7	16	of	of	ADP
ajst-28606	7	17	gene	gene	NOUN
ajst-28606	7	18	editing	editing	NOUN
ajst-28606	7	19	.	.	PUNCT
ajst-28606	8	1	this	this	DET
ajst-28606	8	2	technology	technology	NOUN
ajst-28606	8	3	is	be	AUX
ajst-28606	8	4	highly	highly	ADV
ajst-28606	8	5	specific	specific	ADJ
ajst-28606	8	6	and	and	CCONJ
ajst-28606	8	7	efficient	efficient	ADJ
ajst-28606	8	8	,	,	PUNCT
ajst-28606	8	9	enabling	enable	VERB
ajst-28606	8	10	precise	precise	ADJ
ajst-28606	8	11	editing	editing	NOUN
ajst-28606	8	12	at	at	ADP
ajst-28606	8	13	particular	particular	ADJ
ajst-28606	8	14	locations	location	NOUN
ajst-28606	8	15	within	within	ADP
ajst-28606	8	16	the	the	DET
ajst-28606	8	17	genome	genome	NOUN
ajst-28606	8	18	.	.	PUNCT
ajst-28606	9	1	crispr	crispr	ADJ
ajst-28606	9	2	/	/	SYM
ajst-28606	9	3	cas9	cas9	NOUN
ajst-28606	9	4	technology	technology	NOUN
ajst-28606	9	5	originates	originate	NOUN
ajst-28606	9	6	from	from	ADP
ajst-28606	9	7	the	the	DET
ajst-28606	9	8	immune	immune	ADJ
ajst-28606	9	9	defence	defence	NOUN
ajst-28606	9	10	mechanism	mechanism	NOUN
ajst-28606	9	11	of	of	ADP
ajst-28606	9	12	bacteria	bacteria	NOUN
ajst-28606	9	13	.	.	PUNCT
ajst-28606	10	1	bacteria	bacteria	NOUN
ajst-28606	10	2	record	record	NOUN
ajst-28606	10	3	and	and	CCONJ
ajst-28606	10	4	store	store	NOUN
ajst-28606	10	5	gene	gene	NOUN
ajst-28606	10	6	fragments	fragment	NOUN
ajst-28606	10	7	of	of	ADP
ajst-28606	10	8	invading	invade	VERB
ajst-28606	10	9	viruses	virus	NOUN
ajst-28606	10	10	through	through	ADP
ajst-28606	10	11	crispr	crispr	ADJ
ajst-28606	10	12	sequences	sequence	NOUN
ajst-28606	10	13	and	and	CCONJ
ajst-28606	10	14	use	use	VERB
ajst-28606	10	15	these	these	DET
ajst-28606	10	16	sequences	sequence	NOUN
ajst-28606	10	17	to	to	PART
ajst-28606	10	18	direct	direct	VERB
ajst-28606	10	19	cas9	cas9	NOUN
ajst-28606	10	20	proteins	protein	NOUN
ajst-28606	10	21	to	to	PART
ajst-28606	10	22	cleave	cleave	VERB
ajst-28606	10	23	viral	viral	ADJ
ajst-28606	10	24	dna	dna	NOUN
ajst-28606	10	25	,	,	PUNCT
ajst-28606	10	26	thereby	thereby	ADV
ajst-28606	10	27	fending	fend	VERB
ajst-28606	10	28	off	off	ADP
ajst-28606	10	29	viral	viral	ADJ
ajst-28606	10	30	infections	infection	NOUN
ajst-28606	10	31	.	.	PUNCT
ajst-28606	11	1	drawing	draw	VERB
ajst-28606	11	2	on	on	ADP
ajst-28606	11	3	this	this	DET
ajst-28606	11	4	mechanism	mechanism	NOUN
ajst-28606	11	5	,	,	PUNCT
ajst-28606	11	6	scientists	scientist	NOUN
ajst-28606	11	7	have	have	AUX
ajst-28606	11	8	developed	develop	VERB
ajst-28606	11	9	the	the	DET
ajst-28606	11	10	crispr	crispr	ADJ
ajst-28606	11	11	/	/	SYM
ajst-28606	11	12	cas9	cas9	NOUN
ajst-28606	11	13	gene	gene	NOUN
ajst-28606	11	14	editing	edit	VERB
ajst-28606	11	15	tool	tool	NOUN
ajst-28606	11	16	,	,	PUNCT
ajst-28606	11	17	in	in	ADP
ajst-28606	11	18	which	which	PRON
ajst-28606	11	19	the	the	DET
ajst-28606	11	20	cas9	cas9	NOUN
ajst-28606	11	21	protein	protein	NOUN
ajst-28606	11	22	,	,	PUNCT
ajst-28606	11	23	guided	guide	VERB
ajst-28606	11	24	by	by	ADP
ajst-28606	11	25	grna	grna	NOUN
ajst-28606	11	26	,	,	PUNCT
ajst-28606	11	27	recognises	recognise	VERB
ajst-28606	11	28	and	and	CCONJ
ajst-28606	11	29	cuts	cut	VERB
ajst-28606	11	30	a	a	DET
ajst-28606	11	31	specific	specific	ADJ
ajst-28606	11	32	site	site	NOUN
ajst-28606	11	33	of	of	ADP
ajst-28606	11	34	the	the	DET
ajst-28606	11	35	target	target	NOUN
ajst-28606	11	36	gene	gene	NOUN
ajst-28606	11	37	,	,	PUNCT
ajst-28606	11	38	and	and	CCONJ
ajst-28606	11	39	then	then	ADV
ajst-28606	11	40	the	the	DET
ajst-28606	11	41	cell	cell	NOUN
ajst-28606	11	42	's	's	PART
ajst-28606	11	43	own	own	ADJ
ajst-28606	11	44	dna	dna	PROPN
ajst-28606	11	45	repair	repair	NOUN
ajst-28606	11	46	mechanism	mechanism	NOUN
ajst-28606	11	47	attempts	attempt	VERB
ajst-28606	11	48	to	to	PART
ajst-28606	11	49	repair	repair	VERB
ajst-28606	11	50	the	the	DET
ajst-28606	11	51	breaks	break	NOUN
ajst-28606	11	52	created	create	VERB
ajst-28606	11	53	by	by	ADP
ajst-28606	11	54	the	the	DET
ajst-28606	11	55	cut	cut	NOUN
ajst-28606	11	56	,	,	PUNCT
ajst-28606	11	57	which	which	PRON
ajst-28606	11	58	may	may	AUX
ajst-28606	11	59	trigger	trigger	VERB
ajst-28606	11	60	a	a	DET
ajst-28606	11	61	gene	gene	NOUN
ajst-28606	11	62	mutation	mutation	NOUN
ajst-28606	11	63	or	or	CCONJ
ajst-28606	11	64	the	the	DET
ajst-28606	11	65	insertion	insertion	NOUN
ajst-28606	11	66	of	of	ADP
ajst-28606	11	67	an	an	DET
ajst-28606	11	68	exogenous	exogenous	ADJ
ajst-28606	11	69	gene	gene	NOUN
ajst-28606	11	70	in	in	ADP
ajst-28606	11	71	the	the	DET
ajst-28606	11	72	process	process	NOUN
ajst-28606	11	73	,	,	PUNCT
ajst-28606	11	74	thus	thus	ADV
ajst-28606	11	75	enabling	enable	VERB
ajst-28606	11	76	gene	gene	NOUN
ajst-28606	11	77	editing	editing	NOUN
ajst-28606	11	78	.	.	PUNCT
ajst-28606	12	1	2	2	X
ajst-28606	12	2	.	.	X
ajst-28606	12	3	introduction	introduction	NOUN
ajst-28606	12	4	to	to	ADP
ajst-28606	12	5	the	the	DET
ajst-28606	12	6	mechanism	mechanism	NOUN
ajst-28606	12	7	of	of	ADP
ajst-28606	12	8	crispr	crispr	ADJ
ajst-28606	12	9	/	/	SYM
ajst-28606	12	10	cas9	cas9	NOUN
ajst-28606	12	11	gene	gene	NOUN
ajst-28606	12	12	editing	edit	VERB
ajst-28606	12	13	technology	technology	NOUN
ajst-28606	12	14	the	the	DET
ajst-28606	12	15	crispr	crispr	ADJ
ajst-28606	12	16	/	/	SYM
ajst-28606	12	17	cas9	cas9	NOUN
ajst-28606	12	18	system	system	NOUN
ajst-28606	12	19	mainly	mainly	ADV
ajst-28606	12	20	consists	consist	VERB
ajst-28606	12	21	of	of	ADP
ajst-28606	12	22	a	a	DET
ajst-28606	12	23	guide	guide	NOUN
ajst-28606	12	24	rna	rna	NOUN
ajst-28606	12	25	and	and	CCONJ
ajst-28606	12	26	the	the	DET
ajst-28606	12	27	cas9	cas9	NOUN
ajst-28606	12	28	protein	protein	NOUN
ajst-28606	12	29	,	,	PUNCT
ajst-28606	12	30	which	which	PRON
ajst-28606	12	31	functions	function	NOUN
ajst-28606	12	32	as	as	ADP
ajst-28606	12	33	a	a	DET
ajst-28606	12	34	nucleic	nucleic	ADJ
ajst-28606	12	35	acid	acid	NOUN
ajst-28606	12	36	endonuclease	endonuclease	NOUN
ajst-28606	12	37	.	.	PUNCT
ajst-28606	13	1	during	during	ADP
ajst-28606	13	2	gene	gene	NOUN
ajst-28606	13	3	editing	editing	NOUN
ajst-28606	13	4	,	,	PUNCT
ajst-28606	13	5	researchers	researcher	NOUN
ajst-28606	13	6	combine	combine	VERB
ajst-28606	13	7	crrna	crrna	VERB
ajst-28606	13	8	and	and	CCONJ
ajst-28606	13	9	tracer	tracer	PROPN
ajst-28606	13	10	rna	rna	NOUN
ajst-28606	13	11	to	to	PART
ajst-28606	13	12	form	form	VERB
ajst-28606	13	13	sgrna	sgrna	NOUN
ajst-28606	13	14	,	,	PUNCT
ajst-28606	13	15	which	which	PRON
ajst-28606	13	16	leads	lead	VERB
ajst-28606	13	17	the	the	DET
ajst-28606	13	18	cas9	cas9	NOUN
ajst-28606	13	19	protein	protein	NOUN
ajst-28606	13	20	to	to	PART
ajst-28606	13	21	cut	cut	VERB
ajst-28606	13	22	the	the	DET
ajst-28606	13	23	target	target	NOUN
ajst-28606	13	24	gene	gene	NOUN
ajst-28606	13	25	.	.	PUNCT
ajst-28606	14	1	crispr	crispr	PROPN
ajst-28606	14	2	is	be	AUX
ajst-28606	14	3	divided	divide	VERB
ajst-28606	14	4	into	into	ADP
ajst-28606	14	5	two	two	NUM
ajst-28606	14	6	parts	part	NOUN
ajst-28606	14	7	:	:	PUNCT
ajst-28606	14	8	the	the	DET
ajst-28606	14	9	crispr	crispr	ADJ
ajst-28606	14	10	sequence	sequence	NOUN
ajst-28606	14	11	and	and	CCONJ
ajst-28606	14	12	the	the	DET
ajst-28606	14	13	gene	gene	NOUN
ajst-28606	14	14	encoding	encode	VERB
ajst-28606	14	15	the	the	DET
ajst-28606	14	16	cas	cas	PROPN
ajst-28606	14	17	protein[4	protein[4	PROPN
ajst-28606	14	18	]	]	PUNCT
ajst-28606	14	19	.	.	PUNCT
ajst-28606	15	1	the	the	DET
ajst-28606	15	2	complete	complete	ADJ
ajst-28606	15	3	crispr	crispr	ADJ
ajst-28606	15	4	array	array	NOUN
ajst-28606	15	5	includes	include	VERB
ajst-28606	15	6	spacer	spacer	NOUN
ajst-28606	15	7	sequences	sequence	NOUN
ajst-28606	15	8	and	and	CCONJ
ajst-28606	15	9	repeat	repeat	NOUN
ajst-28606	15	10	sequences	sequence	NOUN
ajst-28606	15	11	.	.	PUNCT
ajst-28606	16	1	repeat	repeat	NOUN
ajst-28606	16	2	sequences	sequence	NOUN
ajst-28606	16	3	(	(	PUNCT
ajst-28606	16	4	each	each	PRON
ajst-28606	16	5	25	25	NUM
ajst-28606	16	6	–	–	PUNCT
ajst-28606	16	7	35	35	NUM
ajst-28606	16	8	bp	bp	NOUN
ajst-28606	16	9	)	)	PUNCT
ajst-28606	16	10	are	be	AUX
ajst-28606	16	11	usually	usually	ADV
ajst-28606	16	12	separated	separate	VERB
ajst-28606	16	13	by	by	ADP
ajst-28606	16	14	spacer	spacer	NOUN
ajst-28606	16	15	sequences	sequence	NOUN
ajst-28606	16	16	(	(	PUNCT
ajst-28606	16	17	each	each	DET
ajst-28606	16	18	30–40	30–40	NUM
ajst-28606	16	19	bp	bp	NOUN
ajst-28606	16	20	)	)	PUNCT
ajst-28606	16	21	,	,	PUNCT
ajst-28606	16	22	and	and	CCONJ
ajst-28606	16	23	the	the	DET
ajst-28606	16	24	cas	cas	PROPN
ajst-28606	16	25	genes	gene	NOUN
ajst-28606	16	26	are	be	AUX
ajst-28606	16	27	usually	usually	ADV
ajst-28606	16	28	situated	situate	VERB
ajst-28606	16	29	close	close	ADV
ajst-28606	16	30	to	to	ADP
ajst-28606	16	31	the	the	DET
ajst-28606	16	32	crispr	crispr	ADJ
ajst-28606	16	33	array	array	NOUN
ajst-28606	16	34	and	and	CCONJ
ajst-28606	16	35	are	be	AUX
ajst-28606	16	36	crucial	crucial	ADJ
ajst-28606	16	37	for	for	ADP
ajst-28606	16	38	capturing	capture	VERB
ajst-28606	16	39	and	and	CCONJ
ajst-28606	16	40	cleaving	cleave	VERB
ajst-28606	16	41	foreign	foreign	ADJ
ajst-28606	16	42	genetic	genetic	ADJ
ajst-28606	16	43	fragments	fragment	NOUN
ajst-28606	16	44	.	.	PUNCT
ajst-28606	17	1	the	the	DET
ajst-28606	17	2	crispr	crispr	ADJ
ajst-28606	17	3	/	/	SYM
ajst-28606	17	4	cas9	cas9	NOUN
ajst-28606	17	5	system	system	NOUN
ajst-28606	17	6	primarily	primarily	ADV
ajst-28606	17	7	involves	involve	VERB
ajst-28606	17	8	three	three	NUM
ajst-28606	17	9	steps	step	NOUN
ajst-28606	17	10	in	in	ADP
ajst-28606	17	11	gene	gene	NOUN
ajst-28606	17	12	editing	editing	NOUN
ajst-28606	17	13	:	:	PUNCT
ajst-28606	17	14	recognition	recognition	NOUN
ajst-28606	17	15	,	,	PUNCT
ajst-28606	17	16	cutting	cutting	NOUN
ajst-28606	17	17	,	,	PUNCT
ajst-28606	17	18	and	and	CCONJ
ajst-28606	17	19	repair	repair	NOUN
ajst-28606	17	20	.	.	PUNCT
ajst-28606	18	1	sgrna	sgrna	PROPN
ajst-28606	18	2	recognizes	recognize	VERB
ajst-28606	18	3	the	the	DET
ajst-28606	18	4	target	target	NOUN
ajst-28606	18	5	sequence	sequence	NOUN
ajst-28606	18	6	by	by	ADP
ajst-28606	18	7	pairing	pair	VERB
ajst-28606	18	8	its	its	PRON
ajst-28606	18	9	5'-crrna	5'-crrna	NOUN
ajst-28606	18	10	with	with	ADP
ajst-28606	18	11	the	the	DET
ajst-28606	18	12	target	target	NOUN
ajst-28606	18	13	gene	gene	NOUN
ajst-28606	18	14	's	's	PART
ajst-28606	18	15	bases	basis	NOUN
ajst-28606	18	16	,	,	PUNCT
ajst-28606	18	17	guiding	guide	VERB
ajst-28606	18	18	the	the	DET
ajst-28606	18	19	cas9	cas9	NOUN
ajst-28606	18	20	nuclease	nuclease	NOUN
ajst-28606	18	21	to	to	ADP
ajst-28606	18	22	the	the	DET
ajst-28606	18	23	target	target	NOUN
ajst-28606	18	24	sequence	sequence	NOUN
ajst-28606	18	25	.	.	PUNCT
ajst-28606	19	1	after	after	ADP
ajst-28606	19	2	the	the	DET
ajst-28606	19	3	rna	rna	NOUN
ajst-28606	19	4	-	-	PUNCT
ajst-28606	19	5	dna	dna	NOUN
ajst-28606	19	6	hybrid	hybrid	NOUN
ajst-28606	19	7	forms	form	NOUN
ajst-28606	19	8	,	,	PUNCT
ajst-28606	19	9	the	the	DET
ajst-28606	19	10	cas9	cas9	NOUN
ajst-28606	19	11	protein	protein	NOUN
ajst-28606	19	12	cuts	cut	VERB
ajst-28606	19	13	the	the	DET
ajst-28606	19	14	dna	dna	NOUN
ajst-28606	19	15	at	at	ADP
ajst-28606	19	16	the	the	DET
ajst-28606	19	17	3	3	NUM
ajst-28606	19	18	bp	bp	PROPN
ajst-28606	19	19	upstream	upstream	NOUN
ajst-28606	19	20	of	of	ADP
ajst-28606	19	21	the	the	DET
ajst-28606	19	22	pam	pam	NOUN
ajst-28606	19	23	sequence	sequence	NOUN
ajst-28606	19	24	,	,	PUNCT
ajst-28606	19	25	resulting	result	VERB
ajst-28606	19	26	in	in	ADP
ajst-28606	19	27	a	a	DET
ajst-28606	19	28	blunt	blunt	ADJ
ajst-28606	19	29	-	-	PUNCT
ajst-28606	19	30	ended	end	VERB
ajst-28606	19	31	double	double	ADJ
ajst-28606	19	32	-	-	PUNCT
ajst-28606	19	33	strand	strand	NOUN
ajst-28606	19	34	break	break	NOUN
ajst-28606	19	35	.	.	PUNCT
ajst-28606	20	1	the	the	DET
ajst-28606	20	2	cell	cell	NOUN
ajst-28606	20	3	then	then	ADV
ajst-28606	20	4	repairs	repair	VERB
ajst-28606	20	5	the	the	DET
ajst-28606	20	6	double	double	ADJ
ajst-28606	20	7	-	-	PUNCT
ajst-28606	20	8	strand	strand	NOUN
ajst-28606	20	9	break	break	NOUN
ajst-28606	20	10	through	through	ADP
ajst-28606	20	11	two	two	NUM
ajst-28606	20	12	main	main	ADJ
ajst-28606	20	13	steps	step	NOUN
ajst-28606	20	14	:	:	PUNCT
ajst-28606	20	15	non	non	ADJ
ajst-28606	20	16	-	-	ADJ
ajst-28606	20	17	homologous	homologous	ADJ
ajst-28606	20	18	end	end	NOUN
ajst-28606	20	19	joining	join	VERB
ajst-28606	20	20	(	(	PUNCT
ajst-28606	20	21	nhej	nhej	ADJ
ajst-28606	20	22	)	)	PUNCT
ajst-28606	20	23	and	and	CCONJ
ajst-28606	20	24	homologous	homologous	ADJ
ajst-28606	20	25	recombination	recombination	NOUN
ajst-28606	20	26	(	(	PUNCT
ajst-28606	20	27	hdr	hdr	NOUN
ajst-28606	20	28	)	)	PUNCT
ajst-28606	20	29	.	.	PUNCT
ajst-28606	21	1	nhej	nhej	ADJ
ajst-28606	21	2	is	be	AUX
ajst-28606	21	3	the	the	DET
ajst-28606	21	4	cell	cell	NOUN
ajst-28606	21	5	's	's	PART
ajst-28606	21	6	primary	primary	ADJ
ajst-28606	21	7	repair	repair	NOUN
ajst-28606	21	8	mechanism	mechanism	NOUN
ajst-28606	21	9	for	for	ADP
ajst-28606	21	10	dna	dna	NOUN
ajst-28606	21	11	breaks	break	NOUN
ajst-28606	21	12	,	,	PUNCT
ajst-28606	21	13	which	which	PRON
ajst-28606	21	14	does	do	AUX
ajst-28606	21	15	not	not	PART
ajst-28606	21	16	require	require	VERB
ajst-28606	21	17	a	a	DET
ajst-28606	21	18	repair	repair	NOUN
ajst-28606	21	19	template	template	NOUN
ajst-28606	21	20	and	and	CCONJ
ajst-28606	21	21	repairs	repair	NOUN
ajst-28606	21	22	dna	dna	PROPN
ajst-28606	21	23	by	by	ADP
ajst-28606	21	24	directly	directly	ADV
ajst-28606	21	25	joining	join	VERB
ajst-28606	21	26	the	the	DET
ajst-28606	21	27	broken	broken	ADJ
ajst-28606	21	28	dna	dna	NOUN
ajst-28606	21	29	ends	end	VERB
ajst-28606	21	30	.	.	PUNCT
ajst-28606	22	1	this	this	DET
ajst-28606	22	2	process	process	NOUN
ajst-28606	22	3	can	can	AUX
ajst-28606	22	4	lead	lead	VERB
ajst-28606	22	5	to	to	ADP
ajst-28606	22	6	insertions	insertion	NOUN
ajst-28606	22	7	or	or	CCONJ
ajst-28606	22	8	deletions	deletion	NOUN
ajst-28606	22	9	(	(	PUNCT
ajst-28606	22	10	indels	indel	NOUN
ajst-28606	22	11	)	)	PUNCT
ajst-28606	22	12	,	,	PUNCT
ajst-28606	22	13	potentially	potentially	ADV
ajst-28606	22	14	causing	cause	VERB
ajst-28606	22	15	gene	gene	NOUN
ajst-28606	22	16	mutations	mutation	NOUN
ajst-28606	22	17	or	or	CCONJ
ajst-28606	22	18	inactivation	inactivation	NOUN
ajst-28606	22	19	.	.	PUNCT
ajst-28606	23	1	in	in	ADP
ajst-28606	23	2	contrast	contrast	NOUN
ajst-28606	23	3	,	,	PUNCT
ajst-28606	23	4	hdr	hdr	NOUN
ajst-28606	23	5	relies	rely	VERB
ajst-28606	23	6	on	on	ADP
ajst-28606	23	7	an	an	DET
ajst-28606	23	8	external	external	ADJ
ajst-28606	23	9	repair	repair	NOUN
ajst-28606	23	10	template	template	NOUN
ajst-28606	23	11	that	that	PRON
ajst-28606	23	12	contains	contain	VERB
ajst-28606	23	13	the	the	DET
ajst-28606	23	14	same	same	ADJ
ajst-28606	23	15	sequence	sequence	NOUN
ajst-28606	23	16	as	as	ADP
ajst-28606	23	17	the	the	DET
ajst-28606	23	18	target	target	NOUN
ajst-28606	23	19	dna	dna	PROPN
ajst-28606	23	20	region	region	NOUN
ajst-28606	23	21	.	.	PUNCT
ajst-28606	24	1	the	the	DET
ajst-28606	24	2	hdr	hdr	NOUN
ajst-28606	24	3	process	process	NOUN
ajst-28606	24	4	uses	use	VERB
ajst-28606	24	5	the	the	DET
ajst-28606	24	6	repair	repair	NOUN
ajst-28606	24	7	template	template	NOUN
ajst-28606	24	8	for	for	ADP
ajst-28606	24	9	precise	precise	ADJ
ajst-28606	24	10	gene	gene	NOUN
ajst-28606	24	11	repair	repair	NOUN
ajst-28606	24	12	or	or	CCONJ
ajst-28606	24	13	insertion	insertion	NOUN
ajst-28606	24	14	,	,	PUNCT
ajst-28606	24	15	achieving	achieve	VERB
ajst-28606	24	16	accurate	accurate	ADJ
ajst-28606	24	17	editing	editing	NOUN
ajst-28606	24	18	of	of	ADP
ajst-28606	24	19	the	the	DET
ajst-28606	24	20	target	target	NOUN
ajst-28606	24	21	gene	gene	NOUN
ajst-28606	24	22	.	.	PUNCT
ajst-28606	25	1	in	in	ADP
ajst-28606	25	2	addition	addition	NOUN
ajst-28606	25	3	,	,	PUNCT
ajst-28606	25	4	the	the	DET
ajst-28606	25	5	crispr	crispr	ADJ
ajst-28606	25	6	/	/	SYM
ajst-28606	25	7	cas9	cas9	NOUN
ajst-28606	25	8	system	system	NOUN
ajst-28606	25	9	also	also	ADV
ajst-28606	25	10	involves	involve	VERB
ajst-28606	25	11	other	other	ADJ
ajst-28606	25	12	extended	extended	ADJ
ajst-28606	25	13	technologies	technology	NOUN
ajst-28606	25	14	,	,	PUNCT
ajst-28606	25	15	such	such	ADJ
ajst-28606	25	16	as	as	ADP
ajst-28606	25	17	crispr	crispr	ADJ
ajst-28606	25	18	/	/	SYM
ajst-28606	25	19	cas12	cas12	NOUN
ajst-28606	25	20	and	and	CCONJ
ajst-28606	25	21	crispr	crispr	ADJ
ajst-28606	25	22	/	/	SYM
ajst-28606	25	23	cas13	cas13	PROPN
ajst-28606	25	24	,	,	PUNCT
ajst-28606	25	25	which	which	PRON
ajst-28606	25	26	have	have	VERB
ajst-28606	25	27	different	different	ADJ
ajst-28606	25	28	characteristics	characteristic	NOUN
ajst-28606	25	29	and	and	CCONJ
ajst-28606	25	30	application	application	NOUN
ajst-28606	25	31	potentials	potential	NOUN
ajst-28606	25	32	.	.	PUNCT
ajst-28606	26	1	crispr	crispr	ADJ
ajst-28606	26	2	/	/	SYM
ajst-28606	26	3	cas12	cas12	PROPN
ajst-28606	26	4	offers	offer	VERB
ajst-28606	26	5	higher	high	ADJ
ajst-28606	26	6	specificity	specificity	NOUN
ajst-28606	26	7	and	and	CCONJ
ajst-28606	26	8	a	a	DET
ajst-28606	26	9	simplified	simplified	ADJ
ajst-28606	26	10	operation	operation	NOUN
ajst-28606	26	11	mode	mode	NOUN
ajst-28606	26	12	,	,	PUNCT
ajst-28606	26	13	while	while	SCONJ
ajst-28606	26	14	crispr	crispr	ADJ
ajst-28606	26	15	/	/	SYM
ajst-28606	26	16	cas13	cas13	PROPN
ajst-28606	26	17	is	be	AUX
ajst-28606	26	18	mainly	mainly	ADV
ajst-28606	26	19	used	use	VERB
ajst-28606	26	20	for	for	ADP
ajst-28606	26	21	rna	rna	NOUN
ajst-28606	26	22	editing	editing	NOUN
ajst-28606	26	23	.	.	PUNCT
ajst-28606	27	1	overall	overall	ADJ
ajst-28606	27	2	,	,	PUNCT
ajst-28606	27	3	crispr	crispr	ADJ
ajst-28606	27	4	/	/	SYM
ajst-28606	27	5	cas9	cas9	NOUN
ajst-28606	27	6	and	and	CCONJ
ajst-28606	27	7	its	its	PRON
ajst-28606	27	8	variants	variant	NOUN
ajst-28606	27	9	provide	provide	VERB
ajst-28606	27	10	flexible	flexible	ADJ
ajst-28606	27	11	and	and	CCONJ
ajst-28606	27	12	powerful	powerful	ADJ
ajst-28606	27	13	tools	tool	NOUN
ajst-28606	27	14	for	for	ADP
ajst-28606	27	15	genome	genome	NOUN
ajst-28606	27	16	editing	editing	NOUN
ajst-28606	27	17	,	,	PUNCT
ajst-28606	27	18	widely	widely	ADV
ajst-28606	27	19	used	use	VERB
ajst-28606	27	20	in	in	ADP
ajst-28606	27	21	basic	basic	ADJ
ajst-28606	27	22	research	research	NOUN
ajst-28606	27	23	,	,	PUNCT
ajst-28606	27	24	therapeutic	therapeutic	ADJ
ajst-28606	27	25	research	research	NOUN
ajst-28606	27	26	,	,	PUNCT
ajst-28606	27	27	and	and	CCONJ
ajst-28606	27	28	agricultural	agricultural	ADJ
ajst-28606	27	29	improvement.[3	improvement.[3	NUM
ajst-28606	27	30	]	]	X
ajst-28606	27	31	3	3	X
ajst-28606	27	32	.	.	PUNCT
ajst-28606	27	33	specific	specific	ADJ
ajst-28606	27	34	use	use	NOUN
ajst-28606	27	35	of	of	ADP
ajst-28606	27	36	crispr	crispr	ADJ
ajst-28606	27	37	/	/	SYM
ajst-28606	27	38	cas	cas	NOUN
ajst-28606	27	39	gene	gene	NOUN
ajst-28606	27	40	editing	edit	VERB
ajst-28606	27	41	technology	technology	NOUN
ajst-28606	27	42	3.1	3.1	NUM
ajst-28606	27	43	.	.	PUNCT
ajst-28606	28	1	treatment	treatment	NOUN
ajst-28606	28	2	of	of	ADP
ajst-28606	28	3	hereditary	hereditary	ADJ
ajst-28606	28	4	diseases	disease	NOUN
ajst-28606	28	5	by	by	ADP
ajst-28606	28	6	correcting	correct	VERB
ajst-28606	28	7	disease	disease	NOUN
ajst-28606	28	8	-	-	PUNCT
ajst-28606	28	9	causing	cause	VERB
ajst-28606	28	10	genes	gene	NOUN
ajst-28606	28	11	,	,	PUNCT
ajst-28606	28	12	crispr	crispr	ADJ
ajst-28606	28	13	/	/	SYM
ajst-28606	28	14	cas9	cas9	NOUN
ajst-28606	28	15	is	be	AUX
ajst-28606	28	16	expected	expect	VERB
ajst-28606	28	17	to	to	PART
ajst-28606	28	18	cure	cure	VERB
ajst-28606	28	19	some	some	DET
ajst-28606	28	20	single	single	ADJ
ajst-28606	28	21	-	-	PUNCT
ajst-28606	28	22	gene	gene	NOUN
ajst-28606	28	23	genetic	genetic	ADJ
ajst-28606	28	24	diseases	disease	NOUN
ajst-28606	28	25	,	,	PUNCT
ajst-28606	28	26	such	such	ADJ
ajst-28606	28	27	as	as	ADP
ajst-28606	28	28	sickle	sickle	NOUN
ajst-28606	28	29	cell	cell	NOUN
ajst-28606	28	30	anemia	anemia	NOUN
ajst-28606	28	31	and	and	CCONJ
ajst-28606	28	32	β	β	NOUN
ajst-28606	28	33	-	-	NOUN
ajst-28606	28	34	thalassemia	thalassemia	NOUN
ajst-28606	29	1	[	[	X
ajst-28606	29	2	1	1	NUM
ajst-28606	29	3	]	]	PUNCT
ajst-28606	29	4	.	.	PUNCT
ajst-28606	30	1	sickle	sickle	PROPN
ajst-28606	30	2	cell	cell	PROPN
ajst-28606	30	3	anemia	anemia	NOUN
ajst-28606	30	4	is	be	AUX
ajst-28606	30	5	caused	cause	VERB
ajst-28606	30	6	by	by	ADP
ajst-28606	30	7	the	the	DET
ajst-28606	30	8	replacement	replacement	NOUN
ajst-28606	30	9	of	of	ADP
ajst-28606	30	10	the	the	DET
ajst-28606	30	11	sixth	sixth	ADJ
ajst-28606	30	12	amino	amino	NOUN
ajst-28606	30	13	acid	acid	NOUN
ajst-28606	30	14	,	,	PUNCT
ajst-28606	30	15	glutamic	glutamic	ADJ
ajst-28606	30	16	acid	acid	NOUN
ajst-28606	30	17	,	,	PUNCT
ajst-28606	30	18	on	on	ADP
ajst-28606	30	19	the	the	DET
ajst-28606	30	20	β	β	NOUN
ajst-28606	30	21	-	-	ADJ
ajst-28606	30	22	peptide	peptide	ADJ
ajst-28606	30	23	chain	chain	NOUN
ajst-28606	30	24	with	with	ADP
ajst-28606	30	25	valine	valine	NOUN
ajst-28606	30	26	,	,	PUNCT
ajst-28606	30	27	forming	form	VERB
ajst-28606	30	28	sickleshaped	sickleshape	VERB
ajst-28606	30	29	hemoglobin	hemoglobin	NOUN
ajst-28606	30	30	.	.	PUNCT
ajst-28606	31	1	crispr	crispr	PROPN
ajst-28606	31	2	/	/	SYM
ajst-28606	31	3	cas9	cas9	NOUN
ajst-28606	31	4	can	can	AUX
ajst-28606	31	5	potentially	potentially	ADV
ajst-28606	31	6	correct	correct	VERB
ajst-28606	31	7	the	the	DET
ajst-28606	31	8	disease	disease	NOUN
ajst-28606	31	9	-	-	PUNCT
ajst-28606	31	10	causing	cause	VERB
ajst-28606	31	11	gene	gene	NOUN
ajst-28606	31	12	to	to	PART
ajst-28606	31	13	achieve	achieve	VERB
ajst-28606	31	14	therapeutic	therapeutic	ADJ
ajst-28606	31	15	effects	effect	NOUN
ajst-28606	31	16	.	.	PUNCT
ajst-28606	32	1	βthalassemia	βthalassemia	ADJ
ajst-28606	32	2	,	,	PUNCT
ajst-28606	32	3	alternatively	alternatively	ADV
ajst-28606	32	4	,	,	PUNCT
ajst-28606	32	5	is	be	AUX
ajst-28606	32	6	caused	cause	VERB
ajst-28606	32	7	by	by	ADP
ajst-28606	32	8	mutations	mutation	NOUN
ajst-28606	32	9	in	in	ADP
ajst-28606	32	10	the	the	DET
ajst-28606	32	11	βglobin	βglobin	PROPN
ajst-28606	32	12	gene	gene	NOUN
ajst-28606	32	13	,	,	PUNCT
ajst-28606	32	14	leading	lead	VERB
ajst-28606	32	15	to	to	ADP
ajst-28606	32	16	ineffective	ineffective	ADJ
ajst-28606	32	17	erythropoiesis	erythropoiesis	NOUN
ajst-28606	32	18	and	and	CCONJ
ajst-28606	32	19	subsequent	subsequent	ADJ
ajst-28606	32	20	anemia	anemia	NOUN
ajst-28606	32	21	.	.	PUNCT
ajst-28606	33	1	gene	gene	NOUN
ajst-28606	33	2	editing	edit	VERB
ajst-28606	33	3	technologies	technology	NOUN
ajst-28606	33	4	,	,	PUNCT
ajst-28606	33	5	especially	especially	ADV
ajst-28606	33	6	crispr	crispr	ADJ
ajst-28606	33	7	/	/	SYM
ajst-28606	33	8	cas9	cas9	NOUN
ajst-28606	33	9	,	,	PUNCT
ajst-28606	33	10	offer	offer	VERB
ajst-28606	33	11	a	a	DET
ajst-28606	33	12	promising	promising	ADJ
ajst-28606	33	13	therapeutic	therapeutic	ADJ
ajst-28606	33	14	approach	approach	NOUN
ajst-28606	33	15	.	.	PUNCT
ajst-28606	34	1	the	the	DET
ajst-28606	34	2	first	first	ADJ
ajst-28606	34	3	step	step	NOUN
ajst-28606	34	4	in	in	ADP
ajst-28606	34	5	gene	gene	NOUN
ajst-28606	34	6	editing	editing	NOUN
ajst-28606	34	7	involves	involve	VERB
ajst-28606	34	8	identifying	identify	VERB
ajst-28606	34	9	and	and	CCONJ
ajst-28606	34	10	localizing	localize	VERB
ajst-28606	34	11	the	the	DET
ajst-28606	34	12	mutated	mutate	VERB
ajst-28606	34	13	βglobin	βglobin	NOUN
ajst-28606	34	14	gene	gene	NOUN
ajst-28606	34	15	locus	locus	NOUN
ajst-28606	34	16	.	.	PUNCT
ajst-28606	35	1	specific	specific	ADJ
ajst-28606	35	2	sgrnas	sgrna	NOUN
ajst-28606	35	3	are	be	AUX
ajst-28606	35	4	designed	design	VERB
ajst-28606	35	5	to	to	PART
ajst-28606	35	6	direct	direct	VERB
ajst-28606	35	7	the	the	DET
ajst-28606	35	8	protein	protein	NOUN
ajst-28606	35	9	to	to	ADP
ajst-28606	35	10	the	the	DET
ajst-28606	35	11	mutation	mutation	NOUN
ajst-28606	35	12	site	site	NOUN
ajst-28606	35	13	,	,	PUNCT
ajst-28606	35	14	where	where	SCONJ
ajst-28606	35	15	the	the	DET
ajst-28606	35	16	cas9	cas9	NOUN
ajst-28606	35	17	protein	protein	NOUN
ajst-28606	35	18	induces	induce	VERB
ajst-28606	35	19	double	double	ADJ
ajst-28606	35	20	-	-	PUNCT
ajst-28606	35	21	stranded	strand	VERB
ajst-28606	35	22	breaks	break	NOUN
ajst-28606	35	23	.	.	PUNCT
ajst-28606	36	1	in	in	ADP
ajst-28606	36	2	the	the	DET
ajst-28606	36	3	in	in	X
ajst-28606	36	4	vitro	vitro	X
ajst-28606	36	5	approach	approach	NOUN
ajst-28606	36	6	,	,	PUNCT
ajst-28606	36	7	hematopoietic	hematopoietic	ADJ
ajst-28606	36	8	stem	stem	NOUN
ajst-28606	36	9	cells	cell	NOUN
ajst-28606	36	10	are	be	AUX
ajst-28606	36	11	extracted	extract	VERB
ajst-28606	36	12	from	from	ADP
ajst-28606	36	13	the	the	DET
ajst-28606	36	14	patient	patient	NOUN
ajst-28606	36	15	,	,	PUNCT
ajst-28606	36	16	edited	edit	VERB
ajst-28606	36	17	genetically	genetically	ADV
ajst-28606	36	18	outside	outside	ADP
ajst-28606	36	19	the	the	DET
ajst-28606	36	20	body	body	NOUN
ajst-28606	36	21	,	,	PUNCT
ajst-28606	36	22	and	and	CCONJ
ajst-28606	36	23	then	then	ADV
ajst-28606	36	24	reinfused	reinfuse	VERB
ajst-28606	36	25	,	,	PUNCT
ajst-28606	36	26	with	with	ADP
ajst-28606	36	27	the	the	DET
ajst-28606	36	28	goal	goal	NOUN
ajst-28606	36	29	133	133	NUM
ajst-28606	36	30	that	that	PRON
ajst-28606	36	31	these	these	DET
ajst-28606	36	32	cells	cell	NOUN
ajst-28606	36	33	will	will	AUX
ajst-28606	36	34	produce	produce	VERB
ajst-28606	36	35	normal	normal	ADJ
ajst-28606	36	36	red	red	ADJ
ajst-28606	36	37	blood	blood	NOUN
ajst-28606	36	38	cells	cell	NOUN
ajst-28606	36	39	in	in	ADP
ajst-28606	36	40	the	the	DET
ajst-28606	36	41	bone	bone	NOUN
ajst-28606	36	42	marrow	marrow	NOUN
ajst-28606	36	43	.	.	PUNCT
ajst-28606	37	1	alternatively	alternatively	ADV
ajst-28606	37	2	,	,	PUNCT
ajst-28606	37	3	in	in	ADP
ajst-28606	37	4	vivo	vivo	NOUN
ajst-28606	37	5	editing	editing	NOUN
ajst-28606	37	6	involves	involves	AUX
ajst-28606	37	7	directly	directly	ADV
ajst-28606	37	8	injecting	inject	VERB
ajst-28606	37	9	the	the	DET
ajst-28606	37	10	crispr	crispr	ADJ
ajst-28606	37	11	/	/	SYM
ajst-28606	37	12	cas9	cas9	NOUN
ajst-28606	37	13	system	system	NOUN
ajst-28606	37	14	into	into	ADP
ajst-28606	37	15	the	the	DET
ajst-28606	37	16	patient	patient	NOUN
ajst-28606	37	17	to	to	PART
ajst-28606	37	18	target	target	VERB
ajst-28606	37	19	the	the	DET
ajst-28606	37	20	hematopoietic	hematopoietic	ADJ
ajst-28606	37	21	stem	stem	NOUN
ajst-28606	37	22	cells	cell	NOUN
ajst-28606	37	23	within	within	ADP
ajst-28606	37	24	the	the	DET
ajst-28606	37	25	body	body	NOUN
ajst-28606	37	26	.	.	PUNCT
ajst-28606	38	1	duchenne	duchenne	PROPN
ajst-28606	38	2	muscular	muscular	ADJ
ajst-28606	38	3	dystrophy	dystrophy	NOUN
ajst-28606	38	4	(	(	PUNCT
ajst-28606	38	5	dmd	dmd	NOUN
ajst-28606	38	6	)	)	PUNCT
ajst-28606	38	7	causes	cause	NOUN
ajst-28606	38	8	from	from	ADP
ajst-28606	38	9	mutations	mutation	NOUN
ajst-28606	38	10	in	in	ADP
ajst-28606	38	11	the	the	DET
ajst-28606	38	12	dmd	dmd	NOUN
ajst-28606	38	13	gene	gene	NOUN
ajst-28606	38	14	.	.	PUNCT
ajst-28606	39	1	crispr	crispr	PROPN
ajst-28606	39	2	can	can	AUX
ajst-28606	39	3	be	be	AUX
ajst-28606	39	4	employed	employ	VERB
ajst-28606	39	5	to	to	PART
ajst-28606	39	6	correct	correct	VERB
ajst-28606	39	7	or	or	CCONJ
ajst-28606	39	8	bypass	bypass	VERB
ajst-28606	39	9	these	these	DET
ajst-28606	39	10	mutations	mutation	NOUN
ajst-28606	39	11	,	,	PUNCT
ajst-28606	39	12	leading	lead	VERB
ajst-28606	39	13	to	to	ADP
ajst-28606	39	14	the	the	DET
ajst-28606	39	15	production	production	NOUN
ajst-28606	39	16	of	of	ADP
ajst-28606	39	17	partially	partially	ADV
ajst-28606	39	18	functional	functional	ADJ
ajst-28606	39	19	dystrophin	dystrophin	ADJ
ajst-28606	39	20	protein	protein	NOUN
ajst-28606	39	21	.	.	PUNCT
ajst-28606	40	1	eliminating	eliminate	VERB
ajst-28606	40	2	the	the	DET
ajst-28606	40	3	mutated	mutate	VERB
ajst-28606	40	4	transcripts	transcript	NOUN
ajst-28606	40	5	can	can	AUX
ajst-28606	40	6	yield	yield	VERB
ajst-28606	40	7	a	a	DET
ajst-28606	40	8	truncated	truncated	ADJ
ajst-28606	40	9	but	but	CCONJ
ajst-28606	40	10	functionally	functionally	ADV
ajst-28606	40	11	adequate	adequate	ADJ
ajst-28606	40	12	dystrophin	dystrophin	ADJ
ajst-28606	40	13	protein	protein	NOUN
ajst-28606	40	14	.	.	PUNCT
ajst-28606	41	1	for	for	ADP
ajst-28606	41	2	instance	instance	NOUN
ajst-28606	41	3	,	,	PUNCT
ajst-28606	41	4	tabebordbar	tabebordbar	NOUN
ajst-28606	41	5	[	[	X
ajst-28606	41	6	13	13	NUM
ajst-28606	41	7	]	]	PUNCT
ajst-28606	41	8	used	use	VERB
ajst-28606	41	9	adeno	adeno	NOUN
ajst-28606	41	10	-	-	PUNCT
ajst-28606	41	11	associated	associate	VERB
ajst-28606	41	12	viral	viral	ADJ
ajst-28606	41	13	vectors	vector	NOUN
ajst-28606	41	14	to	to	PART
ajst-28606	41	15	deliver	deliver	VERB
ajst-28606	41	16	crispr	crispr	ADJ
ajst-28606	41	17	/	/	SYM
ajst-28606	41	18	cas9	cas9	NOUN
ajst-28606	41	19	into	into	ADP
ajst-28606	41	20	an	an	DET
ajst-28606	41	21	mdx	mdx	NOUN
ajst-28606	41	22	mouse	mouse	NOUN
ajst-28606	41	23	model	model	NOUN
ajst-28606	41	24	,	,	PUNCT
ajst-28606	41	25	deleting	delete	VERB
ajst-28606	41	26	the	the	DET
ajst-28606	41	27	mutated	mutate	VERB
ajst-28606	41	28	exon	exon	NOUN
ajst-28606	41	29	23	23	NUM
ajst-28606	41	30	.	.	PUNCT
ajst-28606	42	1	this	this	DET
ajst-28606	42	2	enhanced	enhance	VERB
ajst-28606	42	3	muscle	muscle	NOUN
ajst-28606	42	4	function	function	NOUN
ajst-28606	42	5	,	,	PUNCT
ajst-28606	42	6	restoring	restore	VERB
ajst-28606	42	7	the	the	DET
ajst-28606	42	8	dmd	dmd	NOUN
ajst-28606	42	9	reading	reading	NOUN
ajst-28606	42	10	frame	frame	NOUN
ajst-28606	42	11	and	and	CCONJ
ajst-28606	42	12	enabling	enable	VERB
ajst-28606	42	13	potential	potential	ADJ
ajst-28606	42	14	treatment	treatment	NOUN
ajst-28606	42	15	for	for	ADP
ajst-28606	42	16	duchenne	duchenne	ADJ
ajst-28606	42	17	muscular	muscular	ADJ
ajst-28606	42	18	dystrophy	dystrophy	NOUN
ajst-28606	42	19	.	.	PUNCT
ajst-28606	43	1	the	the	DET
ajst-28606	43	2	team	team	NOUN
ajst-28606	43	3	led	lead	VERB
ajst-28606	43	4	by	by	ADP
ajst-28606	43	5	dennis	dennis	PROPN
ajst-28606	43	6	m.	m.	PROPN
ajst-28606	43	7	k.	k.	PROPN
ajst-28606	43	8	found	find	VERB
ajst-28606	43	9	that	that	SCONJ
ajst-28606	43	10	the	the	DET
ajst-28606	43	11	preprotein	preprotein	PROPN
ajst-28606	43	12	convertase	convertase	PROPN
ajst-28606	43	13	subtilisin	subtilisin	PROPN
ajst-28606	43	14	/	/	SYM
ajst-28606	43	15	kexin	kexin	PROPN
ajst-28606	43	16	type	type	NOUN
ajst-28606	43	17	9	9	NUM
ajst-28606	43	18	(	(	PUNCT
ajst-28606	43	19	pcsk9	pcsk9	NOUN
ajst-28606	43	20	)	)	PUNCT
ajst-28606	43	21	is	be	AUX
ajst-28606	43	22	a	a	DET
ajst-28606	43	23	gene	gene	NOUN
ajst-28606	43	24	participated	participate	VERB
ajst-28606	43	25	in	in	ADP
ajst-28606	43	26	cholesterol	cholesterol	NOUN
ajst-28606	43	27	metabolism	metabolism	NOUN
ajst-28606	43	28	.	.	PUNCT
ajst-28606	44	1	humans	human	NOUN
ajst-28606	44	2	carrying	carry	VERB
ajst-28606	44	3	loss	loss	NOUN
ajst-28606	44	4	-	-	PUNCT
ajst-28606	44	5	of	of	ADP
ajst-28606	44	6	-	-	PUNCT
ajst-28606	44	7	function	function	NOUN
ajst-28606	44	8	mutations	mutation	NOUN
ajst-28606	44	9	in	in	ADP
ajst-28606	44	10	pcsk9	pcsk9	PROPN
ajst-28606	44	11	experience	experience	VERB
ajst-28606	44	12	no	no	DET
ajst-28606	44	13	significant	significant	ADJ
ajst-28606	44	14	adverse	adverse	ADJ
ajst-28606	44	15	effects	effect	NOUN
ajst-28606	44	16	and	and	CCONJ
ajst-28606	44	17	have	have	VERB
ajst-28606	44	18	lower	low	ADJ
ajst-28606	44	19	ldl	ldl	NOUN
ajst-28606	44	20	cholesterol	cholesterol	NOUN
ajst-28606	44	21	levels	level	NOUN
ajst-28606	44	22	,	,	PUNCT
ajst-28606	44	23	lowering	lower	VERB
ajst-28606	44	24	the	the	DET
ajst-28606	44	25	risk	risk	NOUN
ajst-28606	44	26	of	of	ADP
ajst-28606	44	27	various	various	ADJ
ajst-28606	44	28	cardiovascular	cardiovascular	ADJ
ajst-28606	44	29	diseases	disease	NOUN
ajst-28606	44	30	.	.	PUNCT
ajst-28606	45	1	this	this	PRON
ajst-28606	45	2	suggests	suggest	VERB
ajst-28606	45	3	that	that	SCONJ
ajst-28606	45	4	targeting	target	VERB
ajst-28606	45	5	and	and	CCONJ
ajst-28606	45	6	disrupting	disrupt	VERB
ajst-28606	45	7	pcsk9	pcsk9	NOUN
ajst-28606	45	8	with	with	ADP
ajst-28606	45	9	crispr	crispr	ADJ
ajst-28606	45	10	/	/	SYM
ajst-28606	45	11	cas9	cas9	NOUN
ajst-28606	45	12	technology	technology	NOUN
ajst-28606	45	13	could	could	AUX
ajst-28606	45	14	offer	offer	VERB
ajst-28606	45	15	a	a	DET
ajst-28606	45	16	treatment	treatment	NOUN
ajst-28606	45	17	for	for	ADP
ajst-28606	45	18	familial	familial	ADJ
ajst-28606	45	19	hypercholesterolemia	hypercholesterolemia	NOUN
ajst-28606	45	20	[	[	X
ajst-28606	45	21	14	14	NUM
ajst-28606	45	22	]	]	SYM
ajst-28606	45	23	.	.	PUNCT
ajst-28606	46	1	3.2	3.2	NUM
ajst-28606	46	2	.	.	PUNCT
ajst-28606	47	1	cancer	cancer	NOUN
ajst-28606	47	2	treatment	treatment	NOUN
ajst-28606	47	3	crispr	crispr	NOUN
ajst-28606	47	4	/	/	SYM
ajst-28606	47	5	cas9	cas9	NOUN
ajst-28606	47	6	can	can	AUX
ajst-28606	47	7	change	change	VERB
ajst-28606	47	8	the	the	DET
ajst-28606	47	9	cancer	cancer	NOUN
ajst-28606	47	10	-	-	PUNCT
ajst-28606	47	11	related	relate	VERB
ajst-28606	47	12	genes	gene	NOUN
ajst-28606	47	13	and	and	CCONJ
ajst-28606	47	14	improve	improve	VERB
ajst-28606	47	15	the	the	DET
ajst-28606	47	16	ability	ability	NOUN
ajst-28606	47	17	of	of	ADP
ajst-28606	47	18	immune	immune	ADJ
ajst-28606	47	19	cells	cell	NOUN
ajst-28606	47	20	to	to	PART
ajst-28606	47	21	recognize	recognize	VERB
ajst-28606	47	22	and	and	CCONJ
ajst-28606	47	23	get	get	AUX
ajst-28606	47	24	rid	rid	VERB
ajst-28606	47	25	of	of	ADP
ajst-28606	47	26	cancer	cancer	NOUN
ajst-28606	47	27	cells	cell	NOUN
ajst-28606	47	28	,	,	PUNCT
ajst-28606	47	29	opening	open	VERB
ajst-28606	47	30	up	up	ADP
ajst-28606	47	31	new	new	ADJ
ajst-28606	47	32	avenues	avenue	NOUN
ajst-28606	47	33	for	for	ADP
ajst-28606	47	34	cancer	cancer	NOUN
ajst-28606	47	35	immunotherapy.[6	immunotherapy.[6	NOUN
ajst-28606	47	36	]	]	X
ajst-28606	47	37	crispr	crispr	ADJ
ajst-28606	47	38	/	/	SYM
ajst-28606	47	39	cas9	cas9	NOUN
ajst-28606	47	40	technology	technology	NOUN
ajst-28606	47	41	allows	allow	VERB
ajst-28606	47	42	for	for	ADP
ajst-28606	47	43	screening	screen	VERB
ajst-28606	47	44	cancer	cancer	NOUN
ajst-28606	47	45	cells	cell	NOUN
ajst-28606	47	46	to	to	PART
ajst-28606	47	47	determine	determine	VERB
ajst-28606	47	48	their	their	PRON
ajst-28606	47	49	gene	gene	NOUN
ajst-28606	47	50	specificity	specificity	NOUN
ajst-28606	47	51	.	.	PUNCT
ajst-28606	48	1	by	by	ADP
ajst-28606	48	2	targeting	target	VERB
ajst-28606	48	3	and	and	CCONJ
ajst-28606	48	4	deleting	delete	VERB
ajst-28606	48	5	these	these	DET
ajst-28606	48	6	genes	gene	NOUN
ajst-28606	48	7	,	,	PUNCT
ajst-28606	48	8	crispr	crispr	ADJ
ajst-28606	48	9	/	/	SYM
ajst-28606	48	10	cas9	cas9	NOUN
ajst-28606	48	11	can	can	AUX
ajst-28606	48	12	decrease	decrease	VERB
ajst-28606	48	13	the	the	DET
ajst-28606	48	14	viability	viability	NOUN
ajst-28606	48	15	of	of	ADP
ajst-28606	48	16	cancer	cancer	NOUN
ajst-28606	48	17	cells	cell	NOUN
ajst-28606	48	18	.	.	PUNCT
ajst-28606	49	1	additionally	additionally	ADV
ajst-28606	49	2	,	,	PUNCT
ajst-28606	49	3	it	it	PRON
ajst-28606	49	4	can	can	AUX
ajst-28606	49	5	identify	identify	VERB
ajst-28606	49	6	genes	gene	NOUN
ajst-28606	49	7	related	relate	VERB
ajst-28606	49	8	to	to	ADP
ajst-28606	49	9	drug	drug	NOUN
ajst-28606	49	10	resistance	resistance	NOUN
ajst-28606	49	11	in	in	ADP
ajst-28606	49	12	cancer	cancer	NOUN
ajst-28606	49	13	cells	cell	NOUN
ajst-28606	49	14	and	and	CCONJ
ajst-28606	49	15	facilitate	facilitate	VERB
ajst-28606	49	16	research	research	NOUN
ajst-28606	49	17	on	on	ADP
ajst-28606	49	18	overcoming	overcome	VERB
ajst-28606	49	19	this	this	DET
ajst-28606	49	20	resistance	resistance	NOUN
ajst-28606	49	21	[	[	X
ajst-28606	49	22	8	8	NUM
ajst-28606	49	23	]	]	PUNCT
ajst-28606	49	24	.	.	PUNCT
ajst-28606	50	1	for	for	ADP
ajst-28606	50	2	example	example	NOUN
ajst-28606	50	3	,	,	PUNCT
ajst-28606	50	4	immunosuppressive	immunosuppressive	ADJ
ajst-28606	50	5	genes	gene	NOUN
ajst-28606	50	6	such	such	ADJ
ajst-28606	50	7	as	as	ADP
ajst-28606	50	8	pd-1	pd-1	ADP
ajst-28606	50	9	can	can	AUX
ajst-28606	50	10	be	be	AUX
ajst-28606	50	11	knocked	knock	VERB
ajst-28606	50	12	out	out	ADP
ajst-28606	50	13	by	by	ADP
ajst-28606	50	14	crispr	crispr	NOUN
ajst-28606	50	15	to	to	PART
ajst-28606	50	16	enhance	enhance	VERB
ajst-28606	50	17	the	the	DET
ajst-28606	50	18	anti	anti	ADJ
ajst-28606	50	19	-	-	ADJ
ajst-28606	50	20	tumor	tumor	ADJ
ajst-28606	50	21	ability	ability	NOUN
ajst-28606	50	22	of	of	ADP
ajst-28606	50	23	the	the	DET
ajst-28606	50	24	immune	immune	ADJ
ajst-28606	50	25	system[5	system[5	NOUN
ajst-28606	50	26	]	]	PUNCT
ajst-28606	50	27	.	.	PUNCT
ajst-28606	51	1	the	the	DET
ajst-28606	51	2	rupp	rupp	PROPN
ajst-28606	51	3	,	,	PUNCT
ajst-28606	51	4	l.	l.	PROPN
ajst-28606	51	5	j.	j.	PROPN
ajst-28606	51	6	team	team	PROPN
ajst-28606	51	7	demonstrated	demonstrate	VERB
ajst-28606	51	8	this	this	DET
ajst-28606	51	9	approach	approach	NOUN
ajst-28606	51	10	by	by	ADP
ajst-28606	51	11	utilizing	utilize	VERB
ajst-28606	51	12	crispr	crispr	ADJ
ajst-28606	51	13	/	/	SYM
ajst-28606	51	14	cas9	cas9	NOUN
ajst-28606	51	15	to	to	PART
ajst-28606	51	16	delete	delete	VERB
ajst-28606	51	17	the	the	DET
ajst-28606	51	18	pd-1	pd-1	ADJ
ajst-28606	51	19	gene	gene	NOUN
ajst-28606	51	20	in	in	ADP
ajst-28606	51	21	t	t	NOUN
ajst-28606	51	22	cells	cell	NOUN
ajst-28606	51	23	.	.	PUNCT
ajst-28606	51	24	,	,	PUNCT
ajst-28606	51	25	rendering	render	VERB
ajst-28606	51	26	them	they	PRON
ajst-28606	51	27	unsuppressed	unsuppressed	ADJ
ajst-28606	51	28	and	and	CCONJ
ajst-28606	51	29	thus	thus	ADV
ajst-28606	51	30	improving	improve	VERB
ajst-28606	51	31	their	their	PRON
ajst-28606	51	32	anti	anti	ADJ
ajst-28606	51	33	-	-	ADJ
ajst-28606	51	34	tumor	tumor	ADJ
ajst-28606	51	35	activity	activity	NOUN
ajst-28606	51	36	.	.	PUNCT
ajst-28606	52	1	the	the	DET
ajst-28606	52	2	team	team	NOUN
ajst-28606	52	3	found	find	VERB
ajst-28606	52	4	that	that	PRON
ajst-28606	52	5	pd1	pd1	VERB
ajst-28606	52	6	knockout	knockout	NOUN
ajst-28606	52	7	t	t	PROPN
ajst-28606	52	8	cells	cell	NOUN
ajst-28606	52	9	exhibited	exhibit	VERB
ajst-28606	52	10	stronger	strong	ADJ
ajst-28606	52	11	anti	anti	ADJ
ajst-28606	52	12	-	-	ADJ
ajst-28606	52	13	tumor	tumor	ADJ
ajst-28606	52	14	effects	effect	NOUN
ajst-28606	52	15	in	in	ADP
ajst-28606	52	16	a	a	DET
ajst-28606	52	17	mouse	mouse	NOUN
ajst-28606	52	18	model	model	NOUN
ajst-28606	52	19	,	,	PUNCT
ajst-28606	52	20	significantly	significantly	ADV
ajst-28606	52	21	prolonging	prolong	VERB
ajst-28606	52	22	the	the	DET
ajst-28606	52	23	survival	survival	NOUN
ajst-28606	52	24	time	time	NOUN
ajst-28606	52	25	of	of	ADP
ajst-28606	52	26	the	the	DET
ajst-28606	52	27	mice	mouse	NOUN
ajst-28606	52	28	[	[	X
ajst-28606	52	29	19	19	NUM
ajst-28606	52	30	]	]	PUNCT
ajst-28606	52	31	.	.	PUNCT
ajst-28606	53	1	genome	genome	NOUN
ajst-28606	53	2	-	-	PUNCT
ajst-28606	53	3	wide	wide	ADJ
ajst-28606	53	4	screening	screening	NOUN
ajst-28606	53	5	can	can	AUX
ajst-28606	53	6	also	also	ADV
ajst-28606	53	7	be	be	AUX
ajst-28606	53	8	performed	perform	VERB
ajst-28606	53	9	using	use	VERB
ajst-28606	53	10	crispr	crispr	ADJ
ajst-28606	53	11	gene	gene	NOUN
ajst-28606	53	12	editing	edit	VERB
ajst-28606	53	13	technology	technology	NOUN
ajst-28606	53	14	to	to	PART
ajst-28606	53	15	identify	identify	VERB
ajst-28606	53	16	and	and	CCONJ
ajst-28606	53	17	validate	validate	VERB
ajst-28606	53	18	new	new	ADJ
ajst-28606	53	19	cancer	cancer	NOUN
ajst-28606	53	20	therapeutic	therapeutic	ADJ
ajst-28606	53	21	targets	target	NOUN
ajst-28606	53	22	.	.	PUNCT
ajst-28606	54	1	researchers	researcher	NOUN
ajst-28606	54	2	used	use	VERB
ajst-28606	54	3	crispr	crispr	NOUN
ajst-28606	54	4	/	/	SYM
ajst-28606	54	5	cas9	cas9	NOUN
ajst-28606	54	6	to	to	PART
ajst-28606	54	7	conduct	conduct	VERB
ajst-28606	54	8	a	a	DET
ajst-28606	54	9	genome	genome	NOUN
ajst-28606	54	10	-	-	PUNCT
ajst-28606	54	11	wide	wide	ADJ
ajst-28606	54	12	knockout	knockout	NOUN
ajst-28606	54	13	screen	screen	NOUN
ajst-28606	54	14	in	in	ADP
ajst-28606	54	15	cancer	cancer	NOUN
ajst-28606	54	16	cell	cell	NOUN
ajst-28606	54	17	lines	line	NOUN
ajst-28606	54	18	,	,	PUNCT
ajst-28606	54	19	revealing	reveal	VERB
ajst-28606	54	20	several	several	ADJ
ajst-28606	54	21	new	new	ADJ
ajst-28606	54	22	tumor	tumor	NOUN
ajst-28606	54	23	suppressor	suppressor	NOUN
ajst-28606	54	24	genes	gene	NOUN
ajst-28606	54	25	.	.	PUNCT
ajst-28606	55	1	inactivating	inactivate	VERB
ajst-28606	55	2	these	these	DET
ajst-28606	55	3	genes	gene	NOUN
ajst-28606	55	4	can	can	AUX
ajst-28606	55	5	significantly	significantly	ADV
ajst-28606	55	6	promote	promote	VERB
ajst-28606	55	7	tumor	tumor	NOUN
ajst-28606	55	8	growth	growth	NOUN
ajst-28606	55	9	and	and	CCONJ
ajst-28606	55	10	provide	provide	VERB
ajst-28606	55	11	new	new	ADJ
ajst-28606	55	12	targets	target	NOUN
ajst-28606	55	13	for	for	ADP
ajst-28606	55	14	cancer	cancer	NOUN
ajst-28606	55	15	therapy	therapy	NOUN
ajst-28606	55	16	[	[	X
ajst-28606	55	17	20	20	NUM
ajst-28606	55	18	]	]	PUNCT
ajst-28606	55	19	.	.	PUNCT
ajst-28606	56	1	it	it	PRON
ajst-28606	56	2	is	be	AUX
ajst-28606	56	3	also	also	ADV
ajst-28606	56	4	possible	possible	ADJ
ajst-28606	56	5	to	to	PART
ajst-28606	56	6	examine	examine	VERB
ajst-28606	56	7	the	the	DET
ajst-28606	56	8	genomes	genome	NOUN
ajst-28606	56	9	of	of	ADP
ajst-28606	56	10	cancer	cancer	NOUN
ajst-28606	56	11	patients	patient	NOUN
ajst-28606	56	12	for	for	ADP
ajst-28606	56	13	partial	partial	ADJ
ajst-28606	56	14	gene	gene	NOUN
ajst-28606	56	15	inactivation	inactivation	NOUN
ajst-28606	56	16	and	and	CCONJ
ajst-28606	56	17	use	use	VERB
ajst-28606	56	18	crispr	crispr	ADJ
ajst-28606	56	19	gene	gene	NOUN
ajst-28606	56	20	editing	edit	VERB
ajst-28606	56	21	to	to	ADP
ajst-28606	56	22	transplant	transplant	NOUN
ajst-28606	56	23	or	or	CCONJ
ajst-28606	56	24	modify	modify	VERB
ajst-28606	56	25	these	these	DET
ajst-28606	56	26	genes	gene	NOUN
ajst-28606	56	27	to	to	PART
ajst-28606	56	28	inhibit	inhibit	VERB
ajst-28606	56	29	tumor	tumor	NOUN
ajst-28606	56	30	growth	growth	NOUN
ajst-28606	56	31	,	,	PUNCT
ajst-28606	56	32	thereby	thereby	ADV
ajst-28606	56	33	potentially	potentially	ADV
ajst-28606	56	34	prolonging	prolong	VERB
ajst-28606	56	35	patients	patient	NOUN
ajst-28606	56	36	'	'	PART
ajst-28606	56	37	lifespans	lifespan	NOUN
ajst-28606	56	38	.	.	PUNCT
ajst-28606	57	1	3.3	3.3	NUM
ajst-28606	57	2	.	.	PUNCT
ajst-28606	58	1	antiviral	antiviral	ADJ
ajst-28606	58	2	therapy	therapy	NOUN
ajst-28606	58	3	for	for	ADP
ajst-28606	58	4	viral	viral	ADJ
ajst-28606	58	5	infections	infection	NOUN
ajst-28606	58	6	,	,	PUNCT
ajst-28606	58	7	crispr	crispr	PROPN
ajst-28606	58	8	/	/	SYM
ajst-28606	58	9	cas9	cas9	NOUN
ajst-28606	58	10	can	can	AUX
ajst-28606	58	11	be	be	AUX
ajst-28606	58	12	used	use	VERB
ajst-28606	58	13	to	to	PART
ajst-28606	58	14	cut	cut	VERB
ajst-28606	58	15	viral	viral	ADJ
ajst-28606	58	16	genomes	genome	NOUN
ajst-28606	58	17	and	and	CCONJ
ajst-28606	58	18	inhibit	inhibit	VERB
ajst-28606	58	19	viral	viral	ADJ
ajst-28606	58	20	replication	replication	NOUN
ajst-28606	58	21	,	,	PUNCT
ajst-28606	58	22	such	such	ADJ
ajst-28606	58	23	as	as	ADP
ajst-28606	58	24	in	in	ADP
ajst-28606	58	25	the	the	DET
ajst-28606	58	26	case	case	NOUN
ajst-28606	58	27	of	of	ADP
ajst-28606	58	28	hiv	hiv	PROPN
ajst-28606	58	29	and	and	CCONJ
ajst-28606	58	30	hepatitis	hepatitis	PROPN
ajst-28606	58	31	b[7	b[7	PROPN
ajst-28606	58	32	]	]	PUNCT
ajst-28606	58	33	.	.	PUNCT
ajst-28606	59	1	in	in	ADP
ajst-28606	59	2	2013	2013	NUM
ajst-28606	59	3	,	,	PUNCT
ajst-28606	59	4	ebina	ebina	NOUN
ajst-28606	59	5	's	's	PART
ajst-28606	59	6	research	research	NOUN
ajst-28606	59	7	group	group	NOUN
ajst-28606	59	8	explored	explore	VERB
ajst-28606	59	9	the	the	DET
ajst-28606	59	10	feasibility	feasibility	NOUN
ajst-28606	59	11	of	of	ADP
ajst-28606	59	12	using	use	VERB
ajst-28606	59	13	crispr	crispr	NOUN
ajst-28606	59	14	/	/	SYM
ajst-28606	59	15	cas9	cas9	NOUN
ajst-28606	59	16	to	to	PART
ajst-28606	59	17	modify	modify	VERB
ajst-28606	59	18	the	the	DET
ajst-28606	59	19	hiv-1	hiv-1	ADJ
ajst-28606	59	20	genome	genome	NOUN
ajst-28606	59	21	and	and	CCONJ
ajst-28606	59	22	inhibit	inhibit	VERB
ajst-28606	59	23	its	its	PRON
ajst-28606	59	24	expression	expression	NOUN
ajst-28606	59	25	.	.	PUNCT
ajst-28606	60	1	they	they	PRON
ajst-28606	60	2	focused	focus	VERB
ajst-28606	60	3	on	on	ADP
ajst-28606	60	4	crispr	crispr	PROPN
ajst-28606	60	5	/	/	SYM
ajst-28606	60	6	cas9	cas9	NOUN
ajst-28606	60	7	assemblies	assembly	NOUN
ajst-28606	60	8	targeting	target	VERB
ajst-28606	60	9	the	the	DET
ajst-28606	60	10	hiv-1	hiv-1	PUNCT
ajst-28606	60	11	long	long	ADJ
ajst-28606	60	12	terminal	terminal	ADJ
ajst-28606	60	13	repeat	repeat	NOUN
ajst-28606	60	14	(	(	PUNCT
ajst-28606	60	15	ltr	ltr	ADJ
ajst-28606	60	16	)	)	PUNCT
ajst-28606	60	17	sequence	sequence	NOUN
ajst-28606	60	18	for	for	ADP
ajst-28606	60	19	their	their	PRON
ajst-28606	60	20	experiments	experiment	NOUN
ajst-28606	60	21	.	.	PUNCT
ajst-28606	61	1	the	the	DET
ajst-28606	61	2	crispr	crispr	ADJ
ajst-28606	61	3	/	/	SYM
ajst-28606	61	4	cas9	cas9	NOUN
ajst-28606	61	5	components	component	NOUN
ajst-28606	61	6	were	be	AUX
ajst-28606	61	7	delivered	deliver	VERB
ajst-28606	61	8	into	into	ADP
ajst-28606	61	9	t	t	NOUN
ajst-28606	61	10	cells	cell	NOUN
ajst-28606	61	11	expressing	express	VERB
ajst-28606	61	12	the	the	DET
ajst-28606	61	13	hiv-1	hiv-1	ADJ
ajst-28606	61	14	ltr	ltr	NOUN
ajst-28606	61	15	,	,	PUNCT
ajst-28606	61	16	both	both	PRON
ajst-28606	61	17	in	in	ADP
ajst-28606	61	18	silenced	silenced	ADJ
ajst-28606	61	19	and	and	CCONJ
ajst-28606	61	20	inducible	inducible	ADJ
ajst-28606	61	21	states	state	NOUN
ajst-28606	61	22	,	,	PUNCT
ajst-28606	61	23	to	to	PART
ajst-28606	61	24	examine	examine	VERB
ajst-28606	61	25	their	their	PRON
ajst-28606	61	26	effect	effect	NOUN
ajst-28606	61	27	on	on	ADP
ajst-28606	61	28	expression	expression	NOUN
ajst-28606	61	29	driven	drive	VERB
ajst-28606	61	30	by	by	ADP
ajst-28606	61	31	the	the	DET
ajst-28606	61	32	ltr.[11	ltr.[11	NOUN
ajst-28606	61	33	]	]	PUNCT
ajst-28606	61	34	.	.	PUNCT
ajst-28606	62	1	ebina	ebina	PROPN
ajst-28606	62	2	's	's	PART
ajst-28606	62	3	group	group	NOUN
ajst-28606	62	4	found	find	VERB
ajst-28606	62	5	that	that	SCONJ
ajst-28606	62	6	the	the	DET
ajst-28606	62	7	crispr	crispr	ADJ
ajst-28606	62	8	/	/	SYM
ajst-28606	62	9	cas9	cas9	NOUN
ajst-28606	62	10	system	system	NOUN
ajst-28606	62	11	significantly	significantly	ADV
ajst-28606	62	12	reduced	reduce	VERB
ajst-28606	62	13	ltr	ltr	ADJ
ajst-28606	62	14	-	-	PUNCT
ajst-28606	62	15	driven	drive	VERB
ajst-28606	62	16	expression	expression	NOUN
ajst-28606	62	17	in	in	ADP
ajst-28606	62	18	response	response	NOUN
ajst-28606	62	19	to	to	ADP
ajst-28606	62	20	stimulation	stimulation	NOUN
ajst-28606	62	21	.	.	PUNCT
ajst-28606	63	1	sequence	sequence	NOUN
ajst-28606	63	2	analysis	analysis	NOUN
ajst-28606	63	3	confirmed	confirm	VERB
ajst-28606	63	4	that	that	SCONJ
ajst-28606	63	5	the	the	DET
ajst-28606	63	6	crispr	crispr	ADJ
ajst-28606	63	7	/	/	SYM
ajst-28606	63	8	cas9	cas9	NOUN
ajst-28606	63	9	system	system	NOUN
ajst-28606	63	10	effectively	effectively	ADV
ajst-28606	63	11	cleaved	cleave	VERB
ajst-28606	63	12	and	and	CCONJ
ajst-28606	63	13	mutated	mutate	VERB
ajst-28606	63	14	ltr	ltr	NOUN
ajst-28606	63	15	targets	target	NOUN
ajst-28606	63	16	.	.	PUNCT
ajst-28606	64	1	in	in	ADP
ajst-28606	64	2	addition	addition	NOUN
ajst-28606	64	3	,	,	PUNCT
ajst-28606	64	4	the	the	DET
ajst-28606	64	5	system	system	NOUN
ajst-28606	64	6	was	be	AUX
ajst-28606	64	7	able	able	ADJ
ajst-28606	64	8	to	to	PART
ajst-28606	64	9	remove	remove	VERB
ajst-28606	64	10	internal	internal	ADJ
ajst-28606	64	11	viral	viral	ADJ
ajst-28606	64	12	genes	gene	NOUN
ajst-28606	64	13	from	from	ADP
ajst-28606	64	14	host	host	NOUN
ajst-28606	64	15	cell	cell	NOUN
ajst-28606	64	16	chromosomes	chromosome	NOUN
ajst-28606	64	17	.	.	PUNCT
ajst-28606	65	1	crispr	crispr	ADJ
ajst-28606	65	2	/	/	SYM
ajst-28606	65	3	cas9	cas9	NOUN
ajst-28606	65	4	technology	technology	NOUN
ajst-28606	65	5	can	can	AUX
ajst-28606	65	6	block	block	VERB
ajst-28606	65	7	the	the	DET
ajst-28606	65	8	transcriptional	transcriptional	ADJ
ajst-28606	65	9	expression	expression	NOUN
ajst-28606	65	10	of	of	ADP
ajst-28606	65	11	the	the	DET
ajst-28606	65	12	hiv-1	hiv-1	X
ajst-28606	65	13	virus	virus	NOUN
ajst-28606	65	14	or	or	CCONJ
ajst-28606	65	15	excise	excise	NOUN
ajst-28606	65	16	latent	latent	NOUN
ajst-28606	65	17	hiv-1	hiv-1	X
ajst-28606	65	18	proviruses	provirus	NOUN
ajst-28606	65	19	directly	directly	ADV
ajst-28606	65	20	from	from	ADP
ajst-28606	65	21	the	the	DET
ajst-28606	65	22	host	host	NOUN
ajst-28606	65	23	genome	genome	NOUN
ajst-28606	65	24	.	.	PUNCT
ajst-28606	66	1	the	the	DET
ajst-28606	66	2	results	result	NOUN
ajst-28606	66	3	demonstrated	demonstrate	VERB
ajst-28606	66	4	that	that	SCONJ
ajst-28606	66	5	crispr	crispr	NOUN
ajst-28606	66	6	/	/	SYM
ajst-28606	66	7	cas9	cas9	NOUN
ajst-28606	66	8	can	can	AUX
ajst-28606	66	9	indeed	indeed	ADV
ajst-28606	66	10	block	block	VERB
ajst-28606	66	11	hiv-1	hiv-1	X
ajst-28606	66	12	transcription	transcription	NOUN
ajst-28606	66	13	and	and	CCONJ
ajst-28606	66	14	directly	directly	ADV
ajst-28606	66	15	remove	remove	VERB
ajst-28606	66	16	latent	latent	NOUN
ajst-28606	66	17	hiv-1	hiv-1	X
ajst-28606	66	18	proviruses	provirus	NOUN
ajst-28606	66	19	from	from	ADP
ajst-28606	66	20	the	the	DET
ajst-28606	66	21	host	host	NOUN
ajst-28606	66	22	genome	genome	NOUN
ajst-28606	67	1	[	[	X
ajst-28606	67	2	12	12	NUM
ajst-28606	67	3	]	]	PUNCT
ajst-28606	67	4	.	.	PUNCT
ajst-28606	68	1	3.4	3.4	NUM
ajst-28606	68	2	.	.	PUNCT
ajst-28606	68	3	gene	gene	NOUN
ajst-28606	68	4	function	function	NOUN
ajst-28606	68	5	studies	study	NOUN
ajst-28606	68	6	by	by	ADP
ajst-28606	68	7	knocking	knock	VERB
ajst-28606	68	8	out	out	ADP
ajst-28606	68	9	or	or	CCONJ
ajst-28606	68	10	activating	activate	VERB
ajst-28606	68	11	specific	specific	ADJ
ajst-28606	68	12	genes	gene	NOUN
ajst-28606	68	13	,	,	PUNCT
ajst-28606	68	14	we	we	PRON
ajst-28606	68	15	can	can	AUX
ajst-28606	68	16	study	study	VERB
ajst-28606	68	17	their	their	PRON
ajst-28606	68	18	functions	function	NOUN
ajst-28606	68	19	and	and	CCONJ
ajst-28606	68	20	mechanisms	mechanism	NOUN
ajst-28606	68	21	of	of	ADP
ajst-28606	68	22	action	action	NOUN
ajst-28606	68	23	in	in	ADP
ajst-28606	68	24	diseases	disease	NOUN
ajst-28606	68	25	,	,	PUNCT
ajst-28606	68	26	thereby	thereby	ADV
ajst-28606	68	27	advancing	advance	VERB
ajst-28606	68	28	basic	basic	ADJ
ajst-28606	68	29	medical	medical	ADJ
ajst-28606	68	30	research	research	NOUN
ajst-28606	68	31	.	.	PUNCT
ajst-28606	69	1	donehower	donehower	NOUN
ajst-28606	69	2	,	,	PUNCT
ajst-28606	69	3	l.a	l.a	PROPN
ajst-28606	69	4	.	.	PROPN
ajst-28606	69	5	and	and	CCONJ
ajst-28606	69	6	his	his	PRON
ajst-28606	69	7	team	team	NOUN
ajst-28606	69	8	found	find	VERB
ajst-28606	69	9	that	that	SCONJ
ajst-28606	69	10	mice	mouse	NOUN
ajst-28606	69	11	with	with	ADP
ajst-28606	69	12	the	the	DET
ajst-28606	69	13	p53	p53	NOUN
ajst-28606	69	14	gene	gene	NOUN
ajst-28606	69	15	knocked	knock	VERB
ajst-28606	69	16	out	out	ADP
ajst-28606	69	17	exhibit	exhibit	VERB
ajst-28606	69	18	a	a	DET
ajst-28606	69	19	high	high	ADJ
ajst-28606	69	20	frequency	frequency	NOUN
ajst-28606	69	21	of	of	ADP
ajst-28606	69	22	spontaneous	spontaneous	ADJ
ajst-28606	69	23	tumorigenesis	tumorigenesis	NOUN
ajst-28606	69	24	,	,	PUNCT
ajst-28606	69	25	including	include	VERB
ajst-28606	69	26	lymphomas	lymphoma	NOUN
ajst-28606	69	27	,	,	PUNCT
ajst-28606	69	28	osteosarcomas	osteosarcoma	NOUN
ajst-28606	69	29	,	,	PUNCT
ajst-28606	69	30	and	and	CCONJ
ajst-28606	69	31	other	other	ADJ
ajst-28606	69	32	types	type	NOUN
ajst-28606	69	33	of	of	ADP
ajst-28606	69	34	tumors	tumor	NOUN
ajst-28606	69	35	.	.	PUNCT
ajst-28606	70	1	this	this	DET
ajst-28606	70	2	observation	observation	NOUN
ajst-28606	70	3	suggests	suggest	VERB
ajst-28606	70	4	that	that	SCONJ
ajst-28606	70	5	p53	p53	NOUN
ajst-28606	70	6	plays	play	VERB
ajst-28606	70	7	a	a	DET
ajst-28606	70	8	crucial	crucial	ADJ
ajst-28606	70	9	role	role	NOUN
ajst-28606	70	10	in	in	ADP
ajst-28606	70	11	tumor	tumor	NOUN
ajst-28606	70	12	suppression	suppression	NOUN
ajst-28606	70	13	.	.	PUNCT
ajst-28606	71	1	mouse	mouse	NOUN
ajst-28606	71	2	cells	cell	NOUN
ajst-28606	71	3	lacking	lack	VERB
ajst-28606	71	4	p53	p53	NOUN
ajst-28606	71	5	are	be	AUX
ajst-28606	71	6	unable	unable	ADJ
ajst-28606	71	7	to	to	PART
ajst-28606	71	8	effectively	effectively	ADV
ajst-28606	71	9	arrest	arrest	VERB
ajst-28606	71	10	cell	cell	NOUN
ajst-28606	71	11	cycle	cycle	NOUN
ajst-28606	71	12	progression	progression	NOUN
ajst-28606	71	13	after	after	ADP
ajst-28606	71	14	dna	dna	PROPN
ajst-28606	71	15	damage	damage	NOUN
ajst-28606	71	16	,	,	PUNCT
ajst-28606	71	17	leading	lead	VERB
ajst-28606	71	18	to	to	ADP
ajst-28606	71	19	genomic	genomic	ADJ
ajst-28606	71	20	instability	instability	NOUN
ajst-28606	71	21	[	[	X
ajst-28606	71	22	16	16	NUM
ajst-28606	71	23	]	]	PUNCT
ajst-28606	71	24	.	.	PUNCT
ajst-28606	72	1	this	this	DET
ajst-28606	72	2	highlights	highlight	VERB
ajst-28606	72	3	the	the	DET
ajst-28606	72	4	progress	progress	NOUN
ajst-28606	72	5	of	of	ADP
ajst-28606	72	6	this	this	DET
ajst-28606	72	7	gene	gene	NOUN
ajst-28606	72	8	editing	edit	VERB
ajst-28606	72	9	technology	technology	NOUN
ajst-28606	72	10	in	in	ADP
ajst-28606	72	11	studying	study	VERB
ajst-28606	72	12	gene	gene	NOUN
ajst-28606	72	13	function	function	NOUN
ajst-28606	72	14	studies	study	NOUN
ajst-28606	72	15	.	.	PUNCT
ajst-28606	73	1	3.5	3.5	NUM
ajst-28606	73	2	.	.	PUNCT
ajst-28606	74	1	virus	virus	NOUN
ajst-28606	74	2	detection	detection	PROPN
ajst-28606	74	3	cas9	cas9	NOUN
ajst-28606	74	4	proteins	protein	NOUN
ajst-28606	74	5	are	be	AUX
ajst-28606	74	6	single	single	ADJ
ajst-28606	74	7	effector	effector	NOUN
ajst-28606	74	8	complexes	complex	NOUN
ajst-28606	74	9	synthesized	synthesize	VERB
ajst-28606	74	10	from	from	ADP
ajst-28606	74	11	tracrrna	tracrrna	NOUN
ajst-28606	74	12	to	to	ADP
ajst-28606	74	13	grnas	grna	NOUN
ajst-28606	74	14	that	that	PRON
ajst-28606	74	15	localize	localize	VERB
ajst-28606	74	16	the	the	DET
ajst-28606	74	17	cleavage	cleavage	NOUN
ajst-28606	74	18	of	of	ADP
ajst-28606	74	19	target	target	NOUN
ajst-28606	74	20	sequences	sequence	NOUN
ajst-28606	74	21	by	by	ADP
ajst-28606	74	22	recognizing	recognize	VERB
ajst-28606	74	23	pam	pam	NOUN
ajst-28606	74	24	sites	site	NOUN
ajst-28606	74	25	.	.	PUNCT
ajst-28606	75	1	the	the	DET
ajst-28606	75	2	specificity	specificity	NOUN
ajst-28606	75	3	of	of	ADP
ajst-28606	75	4	the	the	DET
ajst-28606	75	5	pam	pam	NOUN
ajst-28606	75	6	site	site	NOUN
ajst-28606	75	7	can	can	AUX
ajst-28606	75	8	be	be	AUX
ajst-28606	75	9	utilized	utilize	VERB
ajst-28606	75	10	for	for	ADP
ajst-28606	75	11	virus	virus	NOUN
ajst-28606	75	12	detection	detection	NOUN
ajst-28606	75	13	.	.	PUNCT
ajst-28606	76	1	joung	joung	PROPN
ajst-28606	76	2	,	,	PUNCT
ajst-28606	76	3	j.	j.	PROPN
ajst-28606	76	4	's	's	PART
ajst-28606	76	5	team	team	NOUN
ajst-28606	76	6	employed	employ	VERB
ajst-28606	76	7	the	the	DET
ajst-28606	76	8	sherlock	sherlock	NOUN
ajst-28606	76	9	technique	technique	NOUN
ajst-28606	76	10	to	to	PART
ajst-28606	76	11	detect	detect	VERB
ajst-28606	76	12	sars	sar	NOUN
ajst-28606	76	13	-	-	PUNCT
ajst-28606	76	14	cov-2	cov-2	PART
ajst-28606	76	15	viral	viral	ADJ
ajst-28606	76	16	rna	rna	NOUN
ajst-28606	76	17	using	use	VERB
ajst-28606	76	18	the	the	DET
ajst-28606	76	19	crispr	crispr	ADJ
ajst-28606	76	20	-	-	PUNCT
ajst-28606	76	21	cas13a	cas13a	NOUN
ajst-28606	76	22	system	system	NOUN
ajst-28606	76	23	.	.	PUNCT
ajst-28606	77	1	this	this	DET
ajst-28606	77	2	technology	technology	NOUN
ajst-28606	77	3	first	first	ADV
ajst-28606	77	4	reverse	reverse	ADJ
ajst-28606	77	5	transcribes	transcribe	NOUN
ajst-28606	77	6	the	the	DET
ajst-28606	77	7	viral	viral	ADJ
ajst-28606	77	8	rna	rna	NOUN
ajst-28606	77	9	into	into	ADP
ajst-28606	77	10	cdna	cdna	PROPN
ajst-28606	77	11	and	and	CCONJ
ajst-28606	77	12	then	then	ADV
ajst-28606	77	13	recognizes	recognize	VERB
ajst-28606	77	14	the	the	DET
ajst-28606	77	15	viral	viral	ADJ
ajst-28606	77	16	rna	rna	NOUN
ajst-28606	77	17	sequence	sequence	NOUN
ajst-28606	77	18	with	with	ADP
ajst-28606	77	19	crisprcas13a	crisprcas13a	NOUN
ajst-28606	77	20	in	in	ADP
ajst-28606	77	21	combination	combination	NOUN
ajst-28606	77	22	with	with	ADP
ajst-28606	77	23	a	a	DET
ajst-28606	77	24	specific	specific	ADJ
ajst-28606	77	25	grna	grna	NOUN
ajst-28606	77	26	.	.	PUNCT
ajst-28606	78	1	cas13a	cas13a	NOUN
ajst-28606	78	2	activity	activity	NOUN
ajst-28606	78	3	cleaves	cleave	VERB
ajst-28606	78	4	the	the	DET
ajst-28606	78	5	reporter	reporter	NOUN
ajst-28606	78	6	rna	rna	PROPN
ajst-28606	78	7	,	,	PUNCT
ajst-28606	78	8	producing	produce	VERB
ajst-28606	78	9	a	a	DET
ajst-28606	78	10	fluorescent	fluorescent	ADJ
ajst-28606	78	11	signal	signal	NOUN
ajst-28606	78	12	that	that	PRON
ajst-28606	78	13	signals	signal	VERB
ajst-28606	78	14	the	the	DET
ajst-28606	78	15	presence	presence	NOUN
ajst-28606	78	16	of	of	ADP
ajst-28606	78	17	the	the	DET
ajst-28606	78	18	virus	virus	NOUN
ajst-28606	78	19	.	.	PUNCT
ajst-28606	79	1	this	this	DET
ajst-28606	79	2	assay	assay	NOUN
ajst-28606	79	3	is	be	AUX
ajst-28606	79	4	highly	highly	ADV
ajst-28606	79	5	sensitive	sensitive	ADJ
ajst-28606	79	6	and	and	CCONJ
ajst-28606	79	7	specific	specific	ADJ
ajst-28606	79	8	,	,	PUNCT
ajst-28606	79	9	capable	capable	ADJ
ajst-28606	79	10	of	of	ADP
ajst-28606	79	11	detecting	detect	VERB
ajst-28606	79	12	low	low	ADJ
ajst-28606	79	13	concentrations	concentration	NOUN
ajst-28606	79	14	of	of	ADP
ajst-28606	79	15	sars	sar	NOUN
ajst-28606	79	16	-	-	PUNCT
ajst-28606	79	17	cov-2	cov-2	NOUN
ajst-28606	79	18	rna	rna	NOUN
ajst-28606	79	19	in	in	ADP
ajst-28606	79	20	a	a	DET
ajst-28606	79	21	short	short	ADJ
ajst-28606	79	22	period	period	NOUN
ajst-28606	79	23	of	of	ADP
ajst-28606	79	24	time	time	NOUN
ajst-28606	79	25	[	[	X
ajst-28606	79	26	17	17	NUM
ajst-28606	79	27	]	]	PUNCT
ajst-28606	79	28	.	.	PUNCT
ajst-28606	80	1	gootenberg	gootenberg	PROPN
ajst-28606	80	2	,	,	PUNCT
ajst-28606	80	3	j.	j.	PROPN
ajst-28606	80	4	s.	s.	PROPN
ajst-28606	80	5	also	also	ADV
ajst-28606	80	6	utilized	utilize	VERB
ajst-28606	80	7	sherlock	sherlock	NOUN
ajst-28606	80	8	technology	technology	NOUN
ajst-28606	80	9	to	to	PART
ajst-28606	80	10	detect	detect	VERB
ajst-28606	80	11	dengue	dengue	NOUN
ajst-28606	80	12	viral	viral	ADJ
ajst-28606	80	13	rna	rna	NOUN
ajst-28606	80	14	using	use	VERB
ajst-28606	80	15	the	the	DET
ajst-28606	80	16	crispr	crispr	ADJ
ajst-28606	80	17	-	-	PUNCT
ajst-28606	80	18	cas13a	cas13a	NOUN
ajst-28606	80	19	system	system	NOUN
ajst-28606	80	20	.	.	PUNCT
ajst-28606	81	1	they	they	PRON
ajst-28606	81	2	first	first	ADV
ajst-28606	81	3	amplified	amplify	VERB
ajst-28606	81	4	the	the	DET
ajst-28606	81	5	viral	viral	ADJ
ajst-28606	81	6	rna	rna	NOUN
ajst-28606	81	7	through	through	ADP
ajst-28606	81	8	reverse	reverse	ADJ
ajst-28606	81	9	transcription	transcription	NOUN
ajst-28606	81	10	and	and	CCONJ
ajst-28606	81	11	isothermal	isothermal	ADJ
ajst-28606	81	12	amplification	amplification	NOUN
ajst-28606	81	13	.	.	PUNCT
ajst-28606	82	1	subsequently	subsequently	ADV
ajst-28606	82	2	,	,	PUNCT
ajst-28606	82	3	the	the	DET
ajst-28606	82	4	crispr	crispr	ADJ
ajst-28606	82	5	-	-	PUNCT
ajst-28606	82	6	cas13a	cas13a	NOUN
ajst-28606	82	7	system	system	NOUN
ajst-28606	82	8	was	be	AUX
ajst-28606	82	9	used	use	VERB
ajst-28606	82	10	to	to	PART
ajst-28606	82	11	recognise	recognise	VERB
ajst-28606	82	12	and	and	CCONJ
ajst-28606	82	13	cleave	cleave	VERB
ajst-28606	82	14	specific	specific	ADJ
ajst-28606	82	15	viral	viral	ADJ
ajst-28606	82	16	rna	rna	NOUN
ajst-28606	82	17	sequences	sequence	NOUN
ajst-28606	82	18	,	,	PUNCT
ajst-28606	82	19	generating	generate	VERB
ajst-28606	82	20	a	a	DET
ajst-28606	82	21	fluorescent	fluorescent	ADJ
ajst-28606	82	22	signal	signal	NOUN
ajst-28606	82	23	indicating	indicate	VERB
ajst-28606	82	24	the	the	DET
ajst-28606	82	25	presence	presence	NOUN
ajst-28606	82	26	of	of	ADP
ajst-28606	82	27	the	the	DET
ajst-28606	82	28	virus	virus	NOUN
ajst-28606	82	29	.	.	PUNCT
ajst-28606	83	1	sherlock	sherlock	PROPN
ajst-28606	83	2	technology	technology	PROPN
ajst-28606	83	3	can	can	AUX
ajst-28606	83	4	rapidly	rapidly	ADV
ajst-28606	83	5	detect	detect	VERB
ajst-28606	83	6	the	the	DET
ajst-28606	83	7	dengue	dengue	NOUN
ajst-28606	83	8	virus	virus	NOUN
ajst-28606	83	9	and	and	CCONJ
ajst-28606	83	10	differentiate	differentiate	VERB
ajst-28606	83	11	between	between	ADP
ajst-28606	83	12	different	different	ADJ
ajst-28606	83	13	serotypes	serotype	NOUN
ajst-28606	83	14	[	[	X
ajst-28606	83	15	18	18	NUM
ajst-28606	83	16	]	]	PUNCT
ajst-28606	83	17	.	.	PUNCT
ajst-28606	84	1	the	the	DET
ajst-28606	84	2	application	application	NOUN
ajst-28606	84	3	of	of	ADP
ajst-28606	84	4	crispr	crispr	ADJ
ajst-28606	84	5	technology	technology	NOUN
ajst-28606	84	6	in	in	ADP
ajst-28606	84	7	virus	virus	NOUN
ajst-28606	84	8	detection	detection	NOUN
ajst-28606	84	9	demonstrates	demonstrate	VERB
ajst-28606	84	10	its	its	PRON
ajst-28606	84	11	strong	strong	ADJ
ajst-28606	84	12	potential	potential	NOUN
ajst-28606	84	13	and	and	CCONJ
ajst-28606	84	14	advantages	advantage	NOUN
ajst-28606	84	15	,	,	PUNCT
ajst-28606	84	16	such	such	ADJ
ajst-28606	84	17	as	as	ADP
ajst-28606	84	18	high	high	ADJ
ajst-28606	84	19	sensitivity	sensitivity	NOUN
ajst-28606	84	20	,	,	PUNCT
ajst-28606	84	21	specificity	specificity	NOUN
ajst-28606	84	22	,	,	PUNCT
ajst-28606	84	23	rapid	rapid	ADJ
ajst-28606	84	24	detection	detection	NOUN
ajst-28606	84	25	,	,	PUNCT
ajst-28606	84	26	and	and	CCONJ
ajst-28606	84	27	portability	portability	NOUN
ajst-28606	84	28	.	.	PUNCT
ajst-28606	85	1	these	these	DET
ajst-28606	85	2	effective	effective	ADJ
ajst-28606	85	3	cases	case	NOUN
ajst-28606	85	4	highlight	highlight	VERB
ajst-28606	85	5	the	the	DET
ajst-28606	85	6	utility	utility	NOUN
ajst-28606	85	7	of	of	ADP
ajst-28606	85	8	crispr	crispr	ADJ
ajst-28606	85	9	technology	technology	NOUN
ajst-28606	85	10	in	in	ADP
ajst-28606	85	11	detecting	detect	VERB
ajst-28606	85	12	sars	sar	NOUN
ajst-28606	85	13	-	-	PUNCT
ajst-28606	85	14	cov-2	cov-2	NOUN
ajst-28606	85	15	,	,	PUNCT
ajst-28606	85	16	hpv	hpv	PROPN
ajst-28606	85	17	,	,	PUNCT
ajst-28606	85	18	and	and	CCONJ
ajst-28606	85	19	dengue	dengue	NOUN
ajst-28606	85	20	viruses	virus	NOUN
ajst-28606	85	21	.	.	PUNCT
ajst-28606	86	1	4	4	X
ajst-28606	86	2	.	.	X
ajst-28606	86	3	challenges	challenge	NOUN
ajst-28606	86	4	and	and	CCONJ
ajst-28606	86	5	perspectives	perspective	NOUN
ajst-28606	86	6	of	of	ADP
ajst-28606	86	7	crispr	crispr	ADJ
ajst-28606	86	8	/	/	SYM
ajst-28606	86	9	cas9	cas9	NOUN
ajst-28606	86	10	technology	technology	NOUN
ajst-28606	86	11	crispr	crispr	ADJ
ajst-28606	86	12	/	/	SYM
ajst-28606	86	13	cas9	cas9	NOUN
ajst-28606	86	14	technology	technology	NOUN
ajst-28606	86	15	faces	face	VERB
ajst-28606	86	16	a	a	DET
ajst-28606	86	17	number	number	NOUN
ajst-28606	86	18	of	of	ADP
ajst-28606	86	19	challenges	challenge	NOUN
ajst-28606	86	20	and	and	CCONJ
ajst-28606	86	21	areas	area	NOUN
ajst-28606	86	22	for	for	ADP
ajst-28606	86	23	further	further	ADJ
ajst-28606	86	24	research	research	NOUN
ajst-28606	86	25	in	in	ADP
ajst-28606	86	26	its	its	PRON
ajst-28606	86	27	practical	practical	ADJ
ajst-28606	86	28	application	application	NOUN
ajst-28606	86	29	,	,	PUNCT
ajst-28606	86	30	despite	despite	SCONJ
ajst-28606	86	31	its	its	PRON
ajst-28606	86	32	wide	wide	ADJ
ajst-28606	86	33	range	range	NOUN
ajst-28606	86	34	of	of	ADP
ajst-28606	86	35	applications	application	NOUN
ajst-28606	86	36	.	.	PUNCT
ajst-28606	87	1	the	the	DET
ajst-28606	87	2	main	main	ADJ
ajst-28606	87	3	challenges	challenge	NOUN
ajst-28606	87	4	include	include	VERB
ajst-28606	87	5	off	off	ADP
ajst-28606	87	6	-	-	PUNCT
ajst-28606	87	7	target	target	NOUN
ajst-28606	87	8	effects	effect	NOUN
ajst-28606	87	9	,	,	PUNCT
ajst-28606	87	10	delivery	delivery	NOUN
ajst-28606	87	11	issues	issue	NOUN
ajst-28606	87	12	,	,	PUNCT
ajst-28606	87	13	immune	immune	ADJ
ajst-28606	87	14	response	response	NOUN
ajst-28606	87	15	,	,	PUNCT
ajst-28606	87	16	134	134	NUM
ajst-28606	87	17	genetic	genetic	ADJ
ajst-28606	87	18	stability	stability	NOUN
ajst-28606	87	19	and	and	CCONJ
ajst-28606	87	20	ethical	ethical	ADJ
ajst-28606	87	21	issues	issue	NOUN
ajst-28606	87	22	.	.	PUNCT
ajst-28606	88	1	off	off	ADP
ajst-28606	88	2	-	-	PUNCT
ajst-28606	88	3	target	target	NOUN
ajst-28606	88	4	effects	effect	NOUN
ajst-28606	88	5	refer	refer	VERB
ajst-28606	88	6	to	to	ADP
ajst-28606	88	7	the	the	DET
ajst-28606	88	8	possibility	possibility	NOUN
ajst-28606	88	9	that	that	SCONJ
ajst-28606	88	10	the	the	DET
ajst-28606	88	11	crispr	crispr	ADJ
ajst-28606	88	12	/	/	SYM
ajst-28606	88	13	cas9	cas9	NOUN
ajst-28606	88	14	system	system	NOUN
ajst-28606	88	15	may	may	AUX
ajst-28606	88	16	cut	cut	VERB
ajst-28606	88	17	dna	dna	NOUN
ajst-28606	88	18	at	at	ADP
ajst-28606	88	19	a	a	DET
ajst-28606	88	20	non	non	ADJ
ajst-28606	88	21	-	-	ADJ
ajst-28606	88	22	specific	specific	ADJ
ajst-28606	88	23	location	location	NOUN
ajst-28606	88	24	other	other	ADJ
ajst-28606	88	25	than	than	ADP
ajst-28606	88	26	the	the	DET
ajst-28606	88	27	target	target	NOUN
ajst-28606	88	28	dna	dna	NOUN
ajst-28606	88	29	,	,	PUNCT
ajst-28606	88	30	resulting	result	VERB
ajst-28606	88	31	in	in	ADP
ajst-28606	88	32	unwanted	unwanted	ADJ
ajst-28606	88	33	gene	gene	NOUN
ajst-28606	88	34	mutations	mutation	NOUN
ajst-28606	88	35	or	or	CCONJ
ajst-28606	88	36	interference	interference	NOUN
ajst-28606	88	37	with	with	ADP
ajst-28606	88	38	normal	normal	ADJ
ajst-28606	88	39	gene	gene	NOUN
ajst-28606	88	40	function[10	function[10	NOUN
ajst-28606	88	41	]	]	PUNCT
ajst-28606	88	42	.	.	PUNCT
ajst-28606	89	1	despite	despite	SCONJ
ajst-28606	89	2	improvements	improvement	NOUN
ajst-28606	89	3	through	through	ADP
ajst-28606	89	4	optimization	optimization	NOUN
ajst-28606	89	5	of	of	ADP
ajst-28606	89	6	sgrna	sgrna	NOUN
ajst-28606	89	7	design	design	NOUN
ajst-28606	89	8	and	and	CCONJ
ajst-28606	89	9	cas9	cas9	NOUN
ajst-28606	89	10	protein	protein	NOUN
ajst-28606	89	11	variants	variant	NOUN
ajst-28606	89	12	,	,	PUNCT
ajst-28606	89	13	off	off	ADP
ajst-28606	89	14	-	-	PUNCT
ajst-28606	89	15	target	target	NOUN
ajst-28606	89	16	effects	effect	NOUN
ajst-28606	89	17	remain	remain	VERB
ajst-28606	89	18	an	an	DET
ajst-28606	89	19	important	important	ADJ
ajst-28606	89	20	concern	concern	NOUN
ajst-28606	89	21	.	.	PUNCT
ajst-28606	90	1	delivery	delivery	NOUN
ajst-28606	90	2	issues	issue	NOUN
ajst-28606	90	3	relate	relate	VERB
ajst-28606	90	4	to	to	ADP
ajst-28606	90	5	the	the	DET
ajst-28606	90	6	efficiently	efficiently	ADV
ajst-28606	90	7	introducing	introduce	VERB
ajst-28606	90	8	crispr	crispr	ADJ
ajst-28606	90	9	/	/	SYM
ajst-28606	90	10	cas9	cas9	NOUN
ajst-28606	90	11	components	component	NOUN
ajst-28606	90	12	into	into	ADP
ajst-28606	90	13	cells	cell	NOUN
ajst-28606	90	14	,	,	PUNCT
ajst-28606	90	15	which	which	PRON
ajst-28606	90	16	may	may	AUX
ajst-28606	90	17	require	require	VERB
ajst-28606	90	18	different	different	ADJ
ajst-28606	90	19	delivery	delivery	NOUN
ajst-28606	90	20	strategies	strategy	NOUN
ajst-28606	90	21	for	for	ADP
ajst-28606	90	22	different	different	ADJ
ajst-28606	90	23	cell	cell	NOUN
ajst-28606	90	24	types	type	NOUN
ajst-28606	90	25	and	and	CCONJ
ajst-28606	90	26	tissues	tissue	NOUN
ajst-28606	90	27	,	,	PUNCT
ajst-28606	90	28	such	such	ADJ
ajst-28606	90	29	as	as	ADP
ajst-28606	90	30	viral	viral	ADJ
ajst-28606	90	31	vectors	vector	NOUN
ajst-28606	90	32	,	,	PUNCT
ajst-28606	90	33	nanoparticles	nanoparticle	NOUN
ajst-28606	90	34	or	or	CCONJ
ajst-28606	90	35	electroporation	electroporation	NOUN
ajst-28606	90	36	.	.	PUNCT
ajst-28606	91	1	immunoreactivity	immunoreactivity	PROPN
ajst-28606	91	2	refers	refer	VERB
ajst-28606	91	3	to	to	ADP
ajst-28606	91	4	the	the	DET
ajst-28606	91	5	possibility	possibility	NOUN
ajst-28606	91	6	that	that	SCONJ
ajst-28606	91	7	cas9	cas9	PROPN
ajst-28606	91	8	proteins	protein	NOUN
ajst-28606	91	9	may	may	AUX
ajst-28606	91	10	be	be	AUX
ajst-28606	91	11	recognized	recognize	VERB
ajst-28606	91	12	by	by	ADP
ajst-28606	91	13	the	the	DET
ajst-28606	91	14	body	body	NOUN
ajst-28606	91	15	's	's	PART
ajst-28606	91	16	immune	immune	ADJ
ajst-28606	91	17	system	system	NOUN
ajst-28606	91	18	as	as	ADP
ajst-28606	91	19	exogenous	exogenous	ADJ
ajst-28606	91	20	substances	substance	NOUN
ajst-28606	91	21	,	,	PUNCT
ajst-28606	91	22	generating	generate	VERB
ajst-28606	91	23	an	an	DET
ajst-28606	91	24	immune	immune	ADJ
ajst-28606	91	25	response	response	NOUN
ajst-28606	91	26	that	that	PRON
ajst-28606	91	27	could	could	AUX
ajst-28606	91	28	affect	affect	VERB
ajst-28606	91	29	therapeutic	therapeutic	ADJ
ajst-28606	91	30	efficacy	efficacy	NOUN
ajst-28606	91	31	and	and	CCONJ
ajst-28606	91	32	bring	bring	VERB
ajst-28606	91	33	about	about	ADP
ajst-28606	91	34	side	side	NOUN
ajst-28606	91	35	effects	effect	NOUN
ajst-28606	91	36	.	.	PUNCT
ajst-28606	92	1	genetic	genetic	ADJ
ajst-28606	92	2	stability	stability	NOUN
ajst-28606	92	3	issues	issue	NOUN
ajst-28606	92	4	,	,	PUNCT
ajst-28606	92	5	on	on	ADP
ajst-28606	92	6	the	the	DET
ajst-28606	92	7	other	other	ADJ
ajst-28606	92	8	hand	hand	NOUN
ajst-28606	92	9	,	,	PUNCT
ajst-28606	92	10	relate	relate	VERB
ajst-28606	92	11	to	to	ADP
ajst-28606	92	12	the	the	DET
ajst-28606	92	13	possibility	possibility	NOUN
ajst-28606	92	14	that	that	SCONJ
ajst-28606	92	15	genetic	genetic	ADJ
ajst-28606	92	16	modifications	modification	NOUN
ajst-28606	92	17	introduced	introduce	VERB
ajst-28606	92	18	by	by	ADP
ajst-28606	92	19	crispr	crispr	PROPN
ajst-28606	92	20	/	/	SYM
ajst-28606	92	21	cas9	cas9	NOUN
ajst-28606	92	22	may	may	AUX
ajst-28606	92	23	be	be	AUX
ajst-28606	92	24	destabilized	destabilize	VERB
ajst-28606	92	25	during	during	ADP
ajst-28606	92	26	cell	cell	NOUN
ajst-28606	92	27	division	division	NOUN
ajst-28606	92	28	.	.	PUNCT
ajst-28606	93	1	ethical	ethical	ADJ
ajst-28606	93	2	issues	issue	NOUN
ajst-28606	93	3	relate	relate	VERB
ajst-28606	93	4	to	to	ADP
ajst-28606	93	5	the	the	DET
ajst-28606	93	6	fact	fact	NOUN
ajst-28606	93	7	that	that	SCONJ
ajst-28606	93	8	gene	gene	NOUN
ajst-28606	93	9	editing	edit	VERB
ajst-28606	93	10	techniques	technique	NOUN
ajst-28606	93	11	,	,	PUNCT
ajst-28606	93	12	especially	especially	ADV
ajst-28606	93	13	in	in	ADP
ajst-28606	93	14	embryos	embryo	NOUN
ajst-28606	93	15	and	and	CCONJ
ajst-28606	93	16	germ	germ	NOUN
ajst-28606	93	17	cells	cell	NOUN
ajst-28606	93	18	,	,	PUNCT
ajst-28606	93	19	may	may	AUX
ajst-28606	93	20	give	give	VERB
ajst-28606	93	21	rise	rise	NOUN
ajst-28606	93	22	to	to	ADP
ajst-28606	93	23	ethical	ethical	ADJ
ajst-28606	93	24	controversies	controversy	NOUN
ajst-28606	93	25	,	,	PUNCT
ajst-28606	93	26	requiring	require	VERB
ajst-28606	93	27	a	a	DET
ajst-28606	93	28	balance	balance	NOUN
ajst-28606	93	29	between	between	ADP
ajst-28606	93	30	technological	technological	ADJ
ajst-28606	93	31	advances	advance	NOUN
ajst-28606	93	32	and	and	CCONJ
ajst-28606	93	33	ethical	ethical	ADJ
ajst-28606	93	34	norms	norm	NOUN
ajst-28606	93	35	.	.	PUNCT
ajst-28606	94	1	looking	look	VERB
ajst-28606	94	2	ahead	ahead	ADV
ajst-28606	94	3	,	,	PUNCT
ajst-28606	94	4	research	research	NOUN
ajst-28606	94	5	will	will	AUX
ajst-28606	94	6	aim	aim	VERB
ajst-28606	94	7	to	to	PART
ajst-28606	94	8	enhance	enhance	VERB
ajst-28606	94	9	the	the	DET
ajst-28606	94	10	specificity	specificity	NOUN
ajst-28606	94	11	of	of	ADP
ajst-28606	94	12	gene	gene	NOUN
ajst-28606	94	13	editing	edit	VERB
ajst-28606	94	14	technology	technology	NOUN
ajst-28606	94	15	and	and	CCONJ
ajst-28606	94	16	reduce	reduce	VERB
ajst-28606	94	17	its	its	PRON
ajst-28606	94	18	negative	negative	ADJ
ajst-28606	94	19	effects	effect	NOUN
ajst-28606	94	20	,	,	PUNCT
ajst-28606	94	21	develop	develop	VERB
ajst-28606	94	22	cas	cas	NOUN
ajst-28606	94	23	protein	protein	NOUN
ajst-28606	94	24	variants	variant	NOUN
ajst-28606	94	25	with	with	ADP
ajst-28606	94	26	higher	high	ADJ
ajst-28606	94	27	specificity	specificity	NOUN
ajst-28606	94	28	and	and	CCONJ
ajst-28606	94	29	optimize	optimize	VERB
ajst-28606	94	30	sgrna	sgrna	ADJ
ajst-28606	94	31	design	design	NOUN
ajst-28606	94	32	,	,	PUNCT
ajst-28606	94	33	and	and	CCONJ
ajst-28606	94	34	explore	explore	VERB
ajst-28606	94	35	more	more	ADV
ajst-28606	94	36	efficient	efficient	ADJ
ajst-28606	94	37	and	and	CCONJ
ajst-28606	94	38	safer	safe	ADJ
ajst-28606	94	39	delivery	delivery	NOUN
ajst-28606	94	40	systems	system	NOUN
ajst-28606	94	41	including	include	VERB
ajst-28606	94	42	novel	novel	ADJ
ajst-28606	94	43	nanoparticles	nanoparticle	NOUN
ajst-28606	94	44	,	,	PUNCT
ajst-28606	94	45	smart	smart	ADJ
ajst-28606	94	46	viral	viral	ADJ
ajst-28606	94	47	vectors	vector	NOUN
ajst-28606	94	48	,	,	PUNCT
ajst-28606	94	49	and	and	CCONJ
ajst-28606	94	50	so	so	ADV
ajst-28606	94	51	on	on	ADV
ajst-28606	94	52	,	,	PUNCT
ajst-28606	94	53	in	in	ADP
ajst-28606	94	54	order	order	NOUN
ajst-28606	94	55	to	to	PART
ajst-28606	94	56	improve	improve	VERB
ajst-28606	94	57	editing	edit	VERB
ajst-28606	94	58	efficiency	efficiency	NOUN
ajst-28606	94	59	and	and	CCONJ
ajst-28606	94	60	reduce	reduce	VERB
ajst-28606	94	61	side	side	NOUN
ajst-28606	94	62	effects	effect	NOUN
ajst-28606	94	63	.	.	PUNCT
ajst-28606	95	1	long	long	ADJ
ajst-28606	95	2	-	-	PUNCT
ajst-28606	95	3	term	term	NOUN
ajst-28606	95	4	safety	safety	NOUN
ajst-28606	95	5	assessments	assessment	NOUN
ajst-28606	95	6	will	will	AUX
ajst-28606	95	7	ensure	ensure	VERB
ajst-28606	95	8	the	the	DET
ajst-28606	95	9	stability	stability	NOUN
ajst-28606	95	10	and	and	CCONJ
ajst-28606	95	11	effectiveness	effectiveness	NOUN
ajst-28606	95	12	of	of	ADP
ajst-28606	95	13	the	the	DET
ajst-28606	95	14	technology	technology	NOUN
ajst-28606	95	15	,	,	PUNCT
ajst-28606	95	16	and	and	CCONJ
ajst-28606	95	17	personalized	personalized	ADJ
ajst-28606	95	18	treatment	treatment	NOUN
ajst-28606	95	19	plans	plan	NOUN
ajst-28606	95	20	will	will	AUX
ajst-28606	95	21	tailor	tailor	VERB
ajst-28606	95	22	editing	edit	VERB
ajst-28606	95	23	to	to	ADP
ajst-28606	95	24	the	the	DET
ajst-28606	95	25	genomic	genomic	ADJ
ajst-28606	95	26	characteristics	characteristic	NOUN
ajst-28606	95	27	of	of	ADP
ajst-28606	95	28	specific	specific	ADJ
ajst-28606	95	29	patients	patient	NOUN
ajst-28606	95	30	,	,	PUNCT
ajst-28606	95	31	potentially	potentially	ADV
ajst-28606	95	32	greatly	greatly	ADV
ajst-28606	95	33	improving	improve	VERB
ajst-28606	95	34	treatment	treatment	NOUN
ajst-28606	95	35	efficacy	efficacy	NOUN
ajst-28606	95	36	.	.	PUNCT
ajst-28606	96	1	at	at	ADP
ajst-28606	96	2	the	the	DET
ajst-28606	96	3	same	same	ADJ
ajst-28606	96	4	time	time	NOUN
ajst-28606	96	5	,	,	PUNCT
ajst-28606	96	6	ethical	ethical	ADJ
ajst-28606	96	7	norms	norm	NOUN
ajst-28606	96	8	and	and	CCONJ
ajst-28606	96	9	regulatory	regulatory	ADJ
ajst-28606	96	10	frameworks	framework	NOUN
ajst-28606	96	11	for	for	ADP
ajst-28606	96	12	gene	gene	NOUN
ajst-28606	96	13	editing	edit	VERB
ajst-28606	96	14	technology	technology	NOUN
ajst-28606	96	15	need	need	VERB
ajst-28606	96	16	to	to	PART
ajst-28606	96	17	be	be	AUX
ajst-28606	96	18	developed	develop	VERB
ajst-28606	96	19	and	and	CCONJ
ajst-28606	96	20	improved	improve	VERB
ajst-28606	96	21	to	to	PART
ajst-28606	96	22	safeguard	safeguard	VERB
ajst-28606	96	23	the	the	DET
ajst-28606	96	24	rights	right	NOUN
ajst-28606	96	25	and	and	CCONJ
ajst-28606	96	26	safety	safety	NOUN
ajst-28606	96	27	of	of	ADP
ajst-28606	96	28	patients	patient	NOUN
ajst-28606	96	29	.	.	PUNCT
ajst-28606	97	1	finally	finally	ADV
ajst-28606	97	2	,	,	PUNCT
ajst-28606	97	3	the	the	DET
ajst-28606	97	4	use	use	NOUN
ajst-28606	97	5	of	of	ADP
ajst-28606	97	6	crispr	crispr	ADJ
ajst-28606	97	7	/	/	SYM
ajst-28606	97	8	cas9	cas9	NOUN
ajst-28606	97	9	technology	technology	NOUN
ajst-28606	97	10	will	will	AUX
ajst-28606	97	11	also	also	ADV
ajst-28606	97	12	be	be	AUX
ajst-28606	97	13	expanded	expand	VERB
ajst-28606	97	14	to	to	ADP
ajst-28606	97	15	agriculture	agriculture	NOUN
ajst-28606	97	16	,	,	PUNCT
ajst-28606	97	17	biomanufacturing	biomanufacturing	NOUN
ajst-28606	97	18	and	and	CCONJ
ajst-28606	97	19	environmental	environmental	ADJ
ajst-28606	97	20	protection	protection	NOUN
ajst-28606	97	21	,	,	PUNCT
ajst-28606	97	22	exploring	explore	VERB
ajst-28606	97	23	its	its	PRON
ajst-28606	97	24	potential	potential	NOUN
ajst-28606	97	25	in	in	ADP
ajst-28606	97	26	crop	crop	NOUN
ajst-28606	97	27	improvement	improvement	NOUN
ajst-28606	97	28	,	,	PUNCT
ajst-28606	97	29	disease	disease	NOUN
ajst-28606	97	30	prevention	prevention	NOUN
ajst-28606	97	31	and	and	CCONJ
ajst-28606	97	32	ecological	ecological	ADJ
ajst-28606	97	33	restoration	restoration	NOUN
ajst-28606	97	34	.	.	PUNCT
ajst-28606	98	1	references	reference	NOUN
ajst-28606	98	2	[	[	X
ajst-28606	98	3	1	1	NUM
ajst-28606	98	4	]	]	PUNCT
ajst-28606	98	5	pang	pang	NOUN
ajst-28606	98	6	,	,	PUNCT
ajst-28606	98	7	z.	z.	PROPN
ajst-28606	98	8	,	,	PUNCT
ajst-28606	98	9	guan	guan	PROPN
ajst-28606	98	10	,	,	PUNCT
ajst-28606	98	11	y.	y.	PROPN
ajst-28606	98	12	,	,	PUNCT
ajst-28606	98	13	sun	sun	PROPN
ajst-28606	98	14	,	,	PUNCT
ajst-28606	98	15	j.	j.	PROPN
ajst-28606	98	16	,	,	PUNCT
ajst-28606	98	17	&	&	CCONJ
ajst-28606	98	18	wang	wang	PROPN
ajst-28606	98	19	,	,	PUNCT
ajst-28606	98	20	y.	y.	PROPN
ajst-28606	98	21	(	(	PUNCT
ajst-28606	98	22	2022	2022	NUM
ajst-28606	98	23	)	)	PUNCT
ajst-28606	98	24	.	.	PUNCT
ajst-28606	99	1	advances	advance	NOUN
ajst-28606	99	2	in	in	ADP
ajst-28606	99	3	the	the	DET
ajst-28606	99	4	development	development	NOUN
ajst-28606	99	5	and	and	CCONJ
ajst-28606	99	6	application	application	NOUN
ajst-28606	99	7	of	of	ADP
ajst-28606	99	8	crispr	crispr	ADJ
ajst-28606	99	9	/	/	SYM
ajst-28606	99	10	cas9	cas9	NOUN
ajst-28606	99	11	gene	gene	NOUN
ajst-28606	99	12	editing	edit	VERB
ajst-28606	99	13	tools	tool	NOUN
ajst-28606	99	14	.	.	PUNCT
ajst-28606	100	1	*	*	PUNCT
ajst-28606	100	2	biochemical	biochemical	ADJ
ajst-28606	100	3	engineering	engineering	NOUN
ajst-28606	100	4	*	*	PUNCT
ajst-28606	100	5	,	,	PUNCT
ajst-28606	100	6	(	(	PUNCT
ajst-28606	100	7	5	5	NUM
ajst-28606	100	8	)	)	PUNCT
ajst-28606	100	9	,	,	PUNCT
ajst-28606	100	10	140	140	NUM
ajst-28606	100	11	-	-	SYM
ajst-28606	100	12	148	148	NUM
ajst-28606	100	13	.	.	PUNCT
ajst-28606	101	1	[	[	X
ajst-28606	101	2	2	2	NUM
ajst-28606	101	3	]	]	X
ajst-28606	101	4	wang	wang	PROPN
ajst-28606	101	5	,	,	PUNCT
ajst-28606	101	6	l.	l.	PROPN
ajst-28606	101	7	,	,	PUNCT
ajst-28606	101	8	&	&	CCONJ
ajst-28606	101	9	zhao	zhao	PROPN
ajst-28606	101	10	,	,	PUNCT
ajst-28606	101	11	t.	t.	PROPN
ajst-28606	101	12	(	(	PUNCT
ajst-28606	101	13	2017	2017	NUM
ajst-28606	101	14	)	)	PUNCT
ajst-28606	101	15	.	.	PUNCT
ajst-28606	102	1	the	the	DET
ajst-28606	102	2	principle	principle	NOUN
ajst-28606	102	3	of	of	ADP
ajst-28606	102	4	crispr	crispr	ADJ
ajst-28606	102	5	/	/	SYM
ajst-28606	102	6	cas9	cas9	NOUN
ajst-28606	102	7	and	and	CCONJ
ajst-28606	102	8	its	its	PRON
ajst-28606	102	9	research	research	NOUN
ajst-28606	102	10	progress	progress	NOUN
ajst-28606	102	11	in	in	ADP
ajst-28606	102	12	disease	disease	NOUN
ajst-28606	102	13	treatment	treatment	NOUN
ajst-28606	102	14	.	.	PUNCT
ajst-28606	103	1	*	*	PUNCT
ajst-28606	103	2	developmental	developmental	ADJ
ajst-28606	103	3	medicine	medicine	NOUN
ajst-28606	103	4	electronic	electronic	ADJ
ajst-28606	103	5	journal	journal	NOUN
ajst-28606	103	6	*	*	SYM
ajst-28606	103	7	,	,	PUNCT
ajst-28606	103	8	(	(	PUNCT
ajst-28606	103	9	1	1	NUM
ajst-28606	103	10	)	)	PUNCT
ajst-28606	103	11	,	,	PUNCT
ajst-28606	103	12	35	35	NUM
ajst-28606	103	13	-	-	SYM
ajst-28606	103	14	44	44	NUM
ajst-28606	103	15	.	.	PUNCT
ajst-28606	104	1	[	[	X
ajst-28606	104	2	3	3	NUM
ajst-28606	104	3	]	]	X
ajst-28606	104	4	huang	huang	PROPN
ajst-28606	104	5	,	,	PUNCT
ajst-28606	104	6	j.	j.	PROPN
ajst-28606	104	7	,	,	PUNCT
ajst-28606	104	8	&	&	CCONJ
ajst-28606	104	9	fang	fang	PROPN
ajst-28606	104	10	,	,	PUNCT
ajst-28606	104	11	s.	s.	PROPN
ajst-28606	104	12	(	(	PUNCT
ajst-28606	104	13	2024	2024	NUM
ajst-28606	104	14	)	)	PUNCT
ajst-28606	104	15	.	.	PUNCT
ajst-28606	105	1	advances	advance	NOUN
ajst-28606	105	2	in	in	ADP
ajst-28606	105	3	molecular	molecular	ADJ
ajst-28606	105	4	diagnostics	diagnostic	NOUN
ajst-28606	105	5	applications	application	NOUN
ajst-28606	105	6	based	base	VERB
ajst-28606	105	7	on	on	ADP
ajst-28606	105	8	the	the	DET
ajst-28606	105	9	crispr	crispr	ADJ
ajst-28606	105	10	-	-	PUNCT
ajst-28606	105	11	cas	cas	NOUN
ajst-28606	105	12	system	system	NOUN
ajst-28606	105	13	.	.	PUNCT
ajst-28606	106	1	*	*	PUNCT
ajst-28606	106	2	journal	journal	NOUN
ajst-28606	106	3	of	of	ADP
ajst-28606	106	4	molecular	molecular	ADJ
ajst-28606	106	5	diagnostics	diagnostic	NOUN
ajst-28606	106	6	and	and	CCONJ
ajst-28606	106	7	therapy	therapy	NOUN
ajst-28606	106	8	*	*	PUNCT
ajst-28606	106	9	,	,	PUNCT
ajst-28606	106	10	(	(	PUNCT
ajst-28606	106	11	6	6	NUM
ajst-28606	106	12	)	)	PUNCT
ajst-28606	106	13	,	,	PUNCT
ajst-28606	106	14	989992	989992	NUM
ajst-28606	106	15	+	+	SYM
ajst-28606	106	16	1001	1001	NUM
ajst-28606	106	17	.	.	PUNCT
ajst-28606	107	1	https://doi.org/10.19930/j.cnki.jmdt.2024.06.004	https://doi.org/10.19930/j.cnki.jmdt.2024.06.004	X
ajst-28606	107	2	[	[	X
ajst-28606	107	3	4	4	NUM
ajst-28606	107	4	]	]	SYM
ajst-28606	107	5	wu	wu	PROPN
ajst-28606	107	6	,	,	PUNCT
ajst-28606	107	7	c.	c.	PROPN
ajst-28606	107	8	,	,	PUNCT
ajst-28606	107	9	&	&	CCONJ
ajst-28606	107	10	wang	wang	PROPN
ajst-28606	107	11	,	,	PUNCT
ajst-28606	107	12	d.	d.	PROPN
ajst-28606	107	13	(	(	PUNCT
ajst-28606	107	14	2024	2024	NUM
ajst-28606	107	15	)	)	PUNCT
ajst-28606	107	16	.	.	PUNCT
ajst-28606	108	1	a	a	DET
ajst-28606	108	2	new	new	ADJ
ajst-28606	108	3	era	era	NOUN
ajst-28606	108	4	in	in	ADP
ajst-28606	108	5	disease	disease	NOUN
ajst-28606	108	6	treatment	treatment	NOUN
ajst-28606	108	7	led	lead	VERB
ajst-28606	108	8	by	by	ADP
ajst-28606	108	9	crispr	crispr	NOUN
ajst-28606	108	10	/	/	SYM
ajst-28606	108	11	cas9	cas9	NOUN
ajst-28606	108	12	.	.	PUNCT
ajst-28606	109	1	*	*	PUNCT
ajst-28606	109	2	biology	biology	NOUN
ajst-28606	109	3	teaching	teaching	NOUN
ajst-28606	109	4	*	*	PUNCT
ajst-28606	109	5	,	,	PUNCT
ajst-28606	109	6	(	(	PUNCT
ajst-28606	109	7	1	1	NUM
ajst-28606	109	8	)	)	PUNCT
ajst-28606	109	9	,	,	PUNCT
ajst-28606	109	10	7	7	NUM
ajst-28606	109	11	-	-	SYM
ajst-28606	109	12	10	10	NUM
ajst-28606	109	13	.	.	PUNCT
ajst-28606	110	1	[	[	X
ajst-28606	110	2	5	5	NUM
ajst-28606	110	3	]	]	X
ajst-28606	110	4	chen	chen	PROPN
ajst-28606	110	5	,	,	PUNCT
ajst-28606	110	6	m.	m.	NOUN
ajst-28606	110	7	,	,	PUNCT
ajst-28606	110	8	mao	mao	PROPN
ajst-28606	110	9	,	,	PUNCT
ajst-28606	110	10	a.	a.	PROPN
ajst-28606	110	11	,	,	PUNCT
ajst-28606	110	12	xu	xu	PROPN
ajst-28606	110	13	,	,	PUNCT
ajst-28606	110	14	m.	m.	NOUN
ajst-28606	110	15	,	,	PUNCT
ajst-28606	110	16	weng	weng	PROPN
ajst-28606	110	17	,	,	PUNCT
ajst-28606	110	18	q.	q.	PROPN
ajst-28606	110	19	,	,	PUNCT
ajst-28606	110	20	mao	mao	PROPN
ajst-28606	110	21	,	,	PUNCT
ajst-28606	110	22	j.	j.	PROPN
ajst-28606	110	23	,	,	PUNCT
ajst-28606	110	24	&	&	CCONJ
ajst-28606	110	25	ji	ji	PROPN
ajst-28606	110	26	,	,	PUNCT
ajst-28606	110	27	j.	j.	PROPN
ajst-28606	110	28	(	(	PUNCT
ajst-28606	110	29	2019	2019	NUM
ajst-28606	110	30	)	)	PUNCT
ajst-28606	110	31	.	.	PUNCT
ajst-28606	111	1	crispr	crispr	NOUN
ajst-28606	111	2	-	-	PUNCT
ajst-28606	111	3	cas9	cas9	NOUN
ajst-28606	111	4	for	for	ADP
ajst-28606	111	5	cancer	cancer	NOUN
ajst-28606	111	6	therapy	therapy	NOUN
ajst-28606	111	7	:	:	PUNCT
ajst-28606	111	8	opportunities	opportunity	NOUN
ajst-28606	111	9	and	and	CCONJ
ajst-28606	111	10	challenges	challenge	NOUN
ajst-28606	111	11	.	.	PUNCT
ajst-28606	112	1	cancer	cancer	NOUN
ajst-28606	112	2	letters	letter	NOUN
ajst-28606	112	3	,	,	PUNCT
ajst-28606	112	4	447	447	NUM
ajst-28606	112	5	,	,	PUNCT
ajst-28606	112	6	48–55	48–55	NUM
ajst-28606	112	7	.	.	PUNCT
ajst-28606	113	1	https://doi.org/10.1016/j.canlet.2019.01.017	https://doi.org/10.1016/j.canlet.2019.01.017	NOUN
ajst-28606	114	1	[	[	X
ajst-28606	114	2	6	6	NUM
ajst-28606	114	3	]	]	X
ajst-28606	114	4	savić	savić	PROPN
ajst-28606	114	5	,	,	PUNCT
ajst-28606	114	6	n.	n.	NOUN
ajst-28606	114	7	,	,	PUNCT
ajst-28606	114	8	&	&	CCONJ
ajst-28606	114	9	schwank	schwank	PROPN
ajst-28606	114	10	,	,	PUNCT
ajst-28606	114	11	g.	g.	PROPN
ajst-28606	114	12	(	(	PUNCT
ajst-28606	114	13	2016	2016	NUM
ajst-28606	114	14	)	)	PUNCT
ajst-28606	114	15	.	.	PUNCT
ajst-28606	115	1	advances	advance	NOUN
ajst-28606	115	2	in	in	ADP
ajst-28606	115	3	therapeutic	therapeutic	ADJ
ajst-28606	115	4	crispr	crispr	ADJ
ajst-28606	115	5	/	/	SYM
ajst-28606	115	6	cas9	cas9	NOUN
ajst-28606	115	7	genome	genome	NOUN
ajst-28606	115	8	editing	editing	NOUN
ajst-28606	115	9	.	.	PUNCT
ajst-28606	116	1	translational	translational	ADJ
ajst-28606	116	2	research	research	NOUN
ajst-28606	116	3	:	:	PUNCT
ajst-28606	116	4	the	the	DET
ajst-28606	116	5	journal	journal	NOUN
ajst-28606	116	6	of	of	ADP
ajst-28606	116	7	laboratory	laboratory	NOUN
ajst-28606	116	8	and	and	CCONJ
ajst-28606	116	9	clinical	clinical	ADJ
ajst-28606	116	10	medicine	medicine	NOUN
ajst-28606	116	11	,	,	PUNCT
ajst-28606	116	12	168	168	NUM
ajst-28606	116	13	,	,	PUNCT
ajst-28606	116	14	15–21	15–21	NUM
ajst-28606	116	15	.	.	PUNCT
ajst-28606	116	16	https://doi.org/10.1016/j.trsl.2015.09.008	https://doi.org/10.1016/j.trsl.2015.09.008	NOUN
ajst-28606	117	1	[	[	X
ajst-28606	117	2	7	7	NUM
ajst-28606	117	3	]	]	X
ajst-28606	117	4	wang	wang	PROPN
ajst-28606	117	5	,	,	PUNCT
ajst-28606	117	6	s.	s.	PROPN
ajst-28606	117	7	w.	w.	PROPN
ajst-28606	117	8	,	,	PUNCT
ajst-28606	117	9	gao	gao	PROPN
ajst-28606	117	10	,	,	PUNCT
ajst-28606	117	11	c.	c.	PROPN
ajst-28606	117	12	,	,	PUNCT
ajst-28606	117	13	zheng	zheng	PROPN
ajst-28606	117	14	,	,	PUNCT
ajst-28606	117	15	y.	y.	PROPN
ajst-28606	117	16	m.	m.	PROPN
ajst-28606	117	17	,	,	PUNCT
ajst-28606	117	18	yi	yi	PROPN
ajst-28606	117	19	,	,	PUNCT
ajst-28606	117	20	l.	l.	PROPN
ajst-28606	117	21	,	,	PUNCT
ajst-28606	117	22	lu	lu	PROPN
ajst-28606	117	23	,	,	PUNCT
ajst-28606	117	24	j.	j.	PROPN
ajst-28606	117	25	c.	c.	PROPN
ajst-28606	117	26	,	,	PUNCT
ajst-28606	117	27	huang	huang	PROPN
ajst-28606	117	28	,	,	PUNCT
ajst-28606	117	29	x.	x.	PROPN
ajst-28606	117	30	y.	y.	PROPN
ajst-28606	117	31	,	,	PUNCT
ajst-28606	117	32	cai	cai	PROPN
ajst-28606	117	33	,	,	PUNCT
ajst-28606	117	34	j.	j.	PROPN
ajst-28606	117	35	b.	b.	PROPN
ajst-28606	117	36	,	,	PUNCT
ajst-28606	117	37	zhang	zhang	PROPN
ajst-28606	117	38	,	,	PUNCT
ajst-28606	117	39	p.	p.	PROPN
ajst-28606	117	40	f.	f.	PROPN
ajst-28606	117	41	,	,	PUNCT
ajst-28606	117	42	cui	cui	PROPN
ajst-28606	117	43	,	,	PUNCT
ajst-28606	117	44	y.	y.	PROPN
ajst-28606	117	45	h.	h.	PROPN
ajst-28606	117	46	,	,	PUNCT
ajst-28606	117	47	&	&	CCONJ
ajst-28606	117	48	ke	ke	PROPN
ajst-28606	117	49	,	,	PUNCT
ajst-28606	117	50	a.	a.	PROPN
ajst-28606	117	51	w.	w.	PROPN
ajst-28606	117	52	(	(	PUNCT
ajst-28606	117	53	2022	2022	NUM
ajst-28606	117	54	)	)	PUNCT
ajst-28606	117	55	.	.	PUNCT
ajst-28606	118	1	current	current	ADJ
ajst-28606	118	2	applications	application	NOUN
ajst-28606	118	3	and	and	CCONJ
ajst-28606	118	4	future	future	ADJ
ajst-28606	118	5	perspective	perspective	NOUN
ajst-28606	118	6	of	of	ADP
ajst-28606	118	7	crispr	crispr	ADJ
ajst-28606	118	8	/	/	SYM
ajst-28606	118	9	cas9	cas9	NOUN
ajst-28606	118	10	gene	gene	NOUN
ajst-28606	118	11	editing	edit	VERB
ajst-28606	118	12	in	in	ADP
ajst-28606	118	13	cancer	cancer	NOUN
ajst-28606	118	14	.	.	PUNCT
ajst-28606	119	1	molecular	molecular	ADJ
ajst-28606	119	2	cancer	cancer	NOUN
ajst-28606	119	3	,	,	PUNCT
ajst-28606	119	4	21(1	21(1	NUM
ajst-28606	119	5	)	)	PUNCT
ajst-28606	119	6	,	,	PUNCT
ajst-28606	119	7	57	57	NUM
ajst-28606	119	8	.	.	PUNCT
ajst-28606	119	9	https://doi.org/10.1186/s12943-022-01518-8	https://doi.org/10.1186/s12943-022-01518-8	PRON
ajst-28606	120	1	[	[	X
ajst-28606	120	2	8	8	NUM
ajst-28606	120	3	]	]	SYM
ajst-28606	120	4	doench	doench	NOUN
ajst-28606	120	5	,	,	PUNCT
ajst-28606	120	6	j.	j.	PROPN
ajst-28606	120	7	g.	g.	PROPN
ajst-28606	120	8	,	,	PUNCT
ajst-28606	120	9	fusi	fusi	PROPN
ajst-28606	120	10	,	,	PUNCT
ajst-28606	120	11	n.	n.	NOUN
ajst-28606	120	12	,	,	PUNCT
ajst-28606	120	13	sullender	sullender	NOUN
ajst-28606	120	14	,	,	PUNCT
ajst-28606	120	15	m.	m.	NOUN
ajst-28606	120	16	,	,	PUNCT
ajst-28606	120	17	hegde	hegde	NOUN
ajst-28606	120	18	,	,	PUNCT
ajst-28606	120	19	m.	m.	NOUN
ajst-28606	120	20	,	,	PUNCT
ajst-28606	120	21	vaimberg	vaimberg	PROPN
ajst-28606	120	22	,	,	PUNCT
ajst-28606	120	23	e.	e.	PROPN
ajst-28606	120	24	w.	w.	PROPN
ajst-28606	120	25	,	,	PUNCT
ajst-28606	120	26	donovan	donovan	PROPN
ajst-28606	120	27	,	,	PUNCT
ajst-28606	120	28	k.	k.	PROPN
ajst-28606	120	29	f.	f.	PROPN
ajst-28606	120	30	,	,	PUNCT
ajst-28606	120	31	smith	smith	PROPN
ajst-28606	120	32	,	,	PUNCT
ajst-28606	120	33	i.	i.	PROPN
ajst-28606	120	34	,	,	PUNCT
ajst-28606	120	35	tothova	tothova	PROPN
ajst-28606	120	36	,	,	PUNCT
ajst-28606	120	37	z.	z.	PROPN
ajst-28606	120	38	,	,	PUNCT
ajst-28606	120	39	wilen	wilen	ADJ
ajst-28606	120	40	,	,	PUNCT
ajst-28606	120	41	c.	c.	NOUN
ajst-28606	120	42	,	,	PUNCT
ajst-28606	120	43	orchard	orchard	NOUN
ajst-28606	120	44	,	,	PUNCT
ajst-28606	120	45	r.	r.	PROPN
ajst-28606	120	46	,	,	PUNCT
ajst-28606	120	47	virgin	virgin	PROPN
ajst-28606	120	48	,	,	PUNCT
ajst-28606	120	49	h.	h.	PROPN
ajst-28606	120	50	w.	w.	PROPN
ajst-28606	120	51	,	,	PUNCT
ajst-28606	120	52	listgarten	listgarten	PROPN
ajst-28606	120	53	,	,	PUNCT
ajst-28606	120	54	j.	j.	PROPN
ajst-28606	120	55	,	,	PUNCT
ajst-28606	120	56	&	&	CCONJ
ajst-28606	120	57	root	root	PROPN
ajst-28606	120	58	,	,	PUNCT
ajst-28606	120	59	d.	d.	PROPN
ajst-28606	120	60	e.	e.	PROPN
ajst-28606	120	61	(	(	PUNCT
ajst-28606	120	62	2016	2016	NUM
ajst-28606	120	63	)	)	PUNCT
ajst-28606	120	64	.	.	PUNCT
ajst-28606	121	1	optimized	optimize	VERB
ajst-28606	121	2	sgrna	sgrna	NOUN
ajst-28606	121	3	design	design	NOUN
ajst-28606	121	4	to	to	PART
ajst-28606	121	5	maximize	maximize	VERB
ajst-28606	121	6	activity	activity	NOUN
ajst-28606	121	7	and	and	CCONJ
ajst-28606	121	8	minimize	minimize	VERB
ajst-28606	121	9	off	off	ADP
ajst-28606	121	10	-	-	PUNCT
ajst-28606	121	11	target	target	NOUN
ajst-28606	121	12	effects	effect	NOUN
ajst-28606	121	13	of	of	ADP
ajst-28606	121	14	crispr	crispr	NOUN
ajst-28606	121	15	-	-	PUNCT
ajst-28606	121	16	cas9	cas9	NOUN
ajst-28606	121	17	.	.	PUNCT
ajst-28606	122	1	nature	nature	NOUN
ajst-28606	122	2	biotechnology	biotechnology	PROPN
ajst-28606	122	3	,	,	PUNCT
ajst-28606	122	4	34(2	34(2	NUM
ajst-28606	122	5	)	)	PUNCT
ajst-28606	122	6	,	,	PUNCT
ajst-28606	122	7	184–191	184–191	NUM
ajst-28606	122	8	.	.	PUNCT
ajst-28606	123	1	https://doi.org/10.1038/nbt.3437	https://doi.org/10.1038/nbt.3437	PROPN
ajst-28606	123	2	[	[	X
ajst-28606	123	3	9	9	NUM
ajst-28606	123	4	]	]	X
ajst-28606	123	5	xiao	xiao	PROPN
ajst-28606	123	6	,	,	PUNCT
ajst-28606	123	7	q.	q.	PROPN
ajst-28606	123	8	,	,	PUNCT
ajst-28606	123	9	guo	guo	PROPN
ajst-28606	123	10	,	,	PUNCT
ajst-28606	123	11	d.	d.	PROPN
ajst-28606	123	12	,	,	PUNCT
ajst-28606	123	13	&	&	CCONJ
ajst-28606	123	14	chen	chen	PROPN
ajst-28606	123	15	,	,	PUNCT
ajst-28606	123	16	s.	s.	PROPN
ajst-28606	123	17	(	(	PUNCT
ajst-28606	123	18	2019	2019	NUM
ajst-28606	123	19	)	)	PUNCT
ajst-28606	123	20	.	.	PUNCT
ajst-28606	124	1	application	application	NOUN
ajst-28606	124	2	of	of	ADP
ajst-28606	124	3	crispr	crispr	ADJ
ajst-28606	124	4	/	/	SYM
ajst-28606	124	5	cas9	cas9	NOUN
ajst-28606	124	6	-	-	PUNCT
ajst-28606	124	7	based	base	VERB
ajst-28606	124	8	gene	gene	NOUN
ajst-28606	124	9	editing	edit	VERB
ajst-28606	124	10	in	in	ADP
ajst-28606	124	11	hiv-1	hiv-1	NOUN
ajst-28606	124	12	/	/	SYM
ajst-28606	124	13	aids	aids	PROPN
ajst-28606	124	14	therapy	therapy	NOUN
ajst-28606	124	15	.	.	PUNCT
ajst-28606	125	1	frontiers	frontier	NOUN
ajst-28606	125	2	in	in	ADP
ajst-28606	125	3	cellular	cellular	ADJ
ajst-28606	125	4	and	and	CCONJ
ajst-28606	125	5	infection	infection	NOUN
ajst-28606	125	6	microbiology	microbiology	NOUN
ajst-28606	125	7	,	,	PUNCT
ajst-28606	125	8	9	9	NUM
ajst-28606	125	9	,	,	PUNCT
ajst-28606	125	10	69	69	NUM
ajst-28606	125	11	.	.	PUNCT
ajst-28606	126	1	https://doi.org/10.3389/fcimb.2019.00069	https://doi.org/10.3389/fcimb.2019.00069	PROPN
ajst-28606	126	2	[	[	X
ajst-28606	126	3	10	10	NUM
ajst-28606	126	4	]	]	PUNCT
ajst-28606	126	5	ebina	ebina	NOUN
ajst-28606	126	6	,	,	PUNCT
ajst-28606	126	7	h.	h.	PROPN
ajst-28606	126	8	,	,	PUNCT
ajst-28606	126	9	misawa	misawa	PROPN
ajst-28606	126	10	,	,	PUNCT
ajst-28606	126	11	n.	n.	PROPN
ajst-28606	126	12	,	,	PUNCT
ajst-28606	126	13	kanemura	kanemura	NOUN
ajst-28606	126	14	,	,	PUNCT
ajst-28606	126	15	y.	y.	PROPN
ajst-28606	126	16	,	,	PUNCT
ajst-28606	126	17	&	&	CCONJ
ajst-28606	126	18	koyanagi	koyanagi	PROPN
ajst-28606	126	19	,	,	PUNCT
ajst-28606	126	20	y.	y.	PROPN
ajst-28606	126	21	(	(	PUNCT
ajst-28606	126	22	2013	2013	NUM
ajst-28606	126	23	)	)	PUNCT
ajst-28606	126	24	.	.	PUNCT
ajst-28606	127	1	harnessing	harness	VERB
ajst-28606	127	2	the	the	DET
ajst-28606	127	3	crispr	crispr	ADJ
ajst-28606	127	4	/	/	SYM
ajst-28606	127	5	cas9	cas9	NOUN
ajst-28606	127	6	system	system	NOUN
ajst-28606	127	7	to	to	PART
ajst-28606	127	8	disrupt	disrupt	VERB
ajst-28606	127	9	latent	latent	NOUN
ajst-28606	127	10	hiv-1	hiv-1	X
ajst-28606	127	11	provirus	provirus	NOUN
ajst-28606	127	12	.	.	PUNCT
ajst-28606	128	1	scientific	scientific	ADJ
ajst-28606	128	2	reports	report	NOUN
ajst-28606	128	3	,	,	PUNCT
ajst-28606	128	4	3	3	NUM
ajst-28606	128	5	,	,	PUNCT
ajst-28606	128	6	2510	2510	NUM
ajst-28606	128	7	.	.	PUNCT
ajst-28606	129	1	https://doi.org/10.1038/srep02510	https://doi.org/10.1038/srep02510	PROPN
ajst-28606	129	2	[	[	X
ajst-28606	129	3	11	11	NUM
ajst-28606	129	4	]	]	X
ajst-28606	129	5	tabebordbar	tabebordbar	NOUN
ajst-28606	129	6	m	m	PROPN
ajst-28606	129	7	,	,	PUNCT
ajst-28606	129	8	zhu	zhu	PROPN
ajst-28606	129	9	k	k	PROPN
ajst-28606	129	10	,	,	PUNCT
ajst-28606	129	11	cheng	cheng	PROPN
ajst-28606	129	12	jk	jk	PROPN
ajst-28606	129	13	,	,	PUNCT
ajst-28606	129	14	et	et	PROPN
ajst-28606	129	15	al	al	PROPN
ajst-28606	129	16	.	.	PROPN
ajst-28606	130	1	in	in	ADP
ajst-28606	130	2	vivo	vivo	ADJ
ajst-28606	130	3	gene	gene	NOUN
ajst-28606	130	4	editing	edit	VERB
ajst-28606	130	5	in	in	ADP
ajst-28606	130	6	dystrophic	dystrophic	ADJ
ajst-28606	130	7	mouse	mouse	NOUN
ajst-28606	130	8	muscle	muscle	NOUN
ajst-28606	130	9	and	and	CCONJ
ajst-28606	130	10	muscle	muscle	NOUN
ajst-28606	130	11	stem	stem	NOUN
ajst-28606	130	12	cells［j］.	cells［j］.	PROPN
ajst-28606	130	13	science	science	NOUN
ajst-28606	130	14	,	,	PUNCT
ajst-28606	130	15	2016	2016	NUM
ajst-28606	130	16	,	,	PUNCT
ajst-28606	130	17	351(6271	351(6271	NUM
ajst-28606	130	18	):	):	PUNCT
ajst-28606	130	19	407	407	NUM
ajst-28606	130	20	-	-	SYM
ajst-28606	130	21	411	411	NUM
ajst-28606	130	22	.	.	PUNCT
ajst-28606	131	1	[	[	X
ajst-28606	131	2	12	12	NUM
ajst-28606	131	3	]	]	PUNCT
ajst-28606	131	4	rothgangl	rothgangl	PROPN
ajst-28606	131	5	t	t	PROPN
ajst-28606	131	6	,	,	PUNCT
ajst-28606	131	7	dennis	dennis	PROPN
ajst-28606	131	8	m	m	PROPN
ajst-28606	131	9	k	k	PROPN
ajst-28606	131	10	,	,	PUNCT
ajst-28606	131	11	lin	lin	PROPN
ajst-28606	131	12	p	p	PROPN
ajst-28606	131	13	j	j	PROPN
ajst-28606	131	14	c	c	X
ajst-28606	131	15	,	,	PUNCT
ajst-28606	131	16	et	et	PROPN
ajst-28606	131	17	al.in	al.in	NOUN
ajst-28606	131	18	vivo	vivo	VERB
ajst-28606	131	19	adenine	adenine	ADJ
ajst-28606	131	20	base	base	NOUN
ajst-28606	131	21	editing	editing	NOUN
ajst-28606	131	22	of	of	ADP
ajst-28606	131	23	pcsk9	pcsk9	NOUN
ajst-28606	131	24	in	in	ADP
ajst-28606	131	25	macaques	macaque	NOUN
ajst-28606	131	26	reduces	reduce	VERB
ajst-28606	131	27	ldl	ldl	NOUN
ajst-28606	131	28	cholesterol	cholesterol	NOUN
ajst-28606	131	29	levels[j].nat	levels[j].nat	NOUN
ajst-28606	131	30	biotechnol,2021,39(8):949	biotechnol,2021,39(8):949	NOUN
ajst-28606	131	31	-	-	PUNCT
ajst-28606	131	32	957	957	NUM
ajst-28606	131	33	.	.	PUNCT
ajst-28606	132	1	[	[	X
ajst-28606	132	2	13	13	NUM
ajst-28606	132	3	]	]	SYM
ajst-28606	132	4	donehower	donehower	NOUN
ajst-28606	132	5	,	,	PUNCT
ajst-28606	132	6	l.	l.	PROPN
ajst-28606	132	7	a.	a.	PROPN
ajst-28606	132	8	,	,	PUNCT
ajst-28606	132	9	harvey	harvey	PROPN
ajst-28606	132	10	,	,	PUNCT
ajst-28606	132	11	m.	m.	NOUN
ajst-28606	132	12	,	,	PUNCT
ajst-28606	132	13	slagle	slagle	PROPN
ajst-28606	132	14	,	,	PUNCT
ajst-28606	132	15	b.	b.	PROPN
ajst-28606	132	16	l.	l.	PROPN
ajst-28606	132	17	,	,	PUNCT
ajst-28606	132	18	mcarthur	mcarthur	PROPN
ajst-28606	132	19	,	,	PUNCT
ajst-28606	132	20	m.	m.	PROPN
ajst-28606	132	21	j.	j.	PROPN
ajst-28606	132	22	,	,	PUNCT
ajst-28606	132	23	montgomery	montgomery	PROPN
ajst-28606	132	24	,	,	PUNCT
ajst-28606	132	25	c.	c.	PROPN
ajst-28606	132	26	a.	a.	PROPN
ajst-28606	132	27	,	,	PUNCT
ajst-28606	132	28	jr	jr	PROPN
ajst-28606	132	29	,	,	PUNCT
ajst-28606	132	30	butel	butel	NOUN
ajst-28606	132	31	,	,	PUNCT
ajst-28606	132	32	j.	j.	PROPN
ajst-28606	132	33	s.	s.	PROPN
ajst-28606	132	34	,	,	PUNCT
ajst-28606	132	35	&	&	CCONJ
ajst-28606	132	36	bradley	bradley	PROPN
ajst-28606	132	37	,	,	PUNCT
ajst-28606	132	38	a.	a.	NOUN
ajst-28606	132	39	(	(	PUNCT
ajst-28606	132	40	1992	1992	NUM
ajst-28606	132	41	)	)	PUNCT
ajst-28606	132	42	.	.	PUNCT
ajst-28606	133	1	mice	mouse	NOUN
ajst-28606	133	2	deficient	deficient	ADJ
ajst-28606	133	3	for	for	ADP
ajst-28606	133	4	p53	p53	NOUN
ajst-28606	133	5	are	be	AUX
ajst-28606	133	6	developmentally	developmentally	ADV
ajst-28606	133	7	normal	normal	ADJ
ajst-28606	133	8	but	but	CCONJ
ajst-28606	133	9	susceptible	susceptible	ADJ
ajst-28606	133	10	to	to	ADP
ajst-28606	133	11	spontaneous	spontaneous	ADJ
ajst-28606	133	12	tumours	tumour	NOUN
ajst-28606	133	13	.	.	PUNCT
ajst-28606	134	1	nature	nature	NOUN
ajst-28606	134	2	,	,	PUNCT
ajst-28606	134	3	356(6366	356(6366	NUM
ajst-28606	134	4	)	)	PUNCT
ajst-28606	134	5	,	,	PUNCT
ajst-28606	134	6	215–221	215–221	NUM
ajst-28606	134	7	.	.	PUNCT
ajst-28606	135	1	https://doi.org/10.1038/356215a0	https://doi.org/10.1038/356215a0	PRON
ajst-28606	136	1	[	[	X
ajst-28606	136	2	14	14	NUM
ajst-28606	136	3	]	]	X
ajst-28606	136	4	joung	joung	PROPN
ajst-28606	136	5	,	,	PUNCT
ajst-28606	136	6	j.	j.	PROPN
ajst-28606	136	7	,	,	PUNCT
ajst-28606	136	8	ladha	ladha	PROPN
ajst-28606	136	9	,	,	PUNCT
ajst-28606	136	10	a.	a.	NOUN
ajst-28606	136	11	,	,	PUNCT
ajst-28606	136	12	saito	saito	PROPN
ajst-28606	136	13	,	,	PUNCT
ajst-28606	136	14	m.	m.	NOUN
ajst-28606	136	15	,	,	PUNCT
ajst-28606	136	16	segel	segel	NOUN
ajst-28606	136	17	,	,	PUNCT
ajst-28606	136	18	m.	m.	NOUN
ajst-28606	136	19	,	,	PUNCT
ajst-28606	136	20	bruneau	bruneau	PROPN
ajst-28606	136	21	,	,	PUNCT
ajst-28606	136	22	r.	r.	PROPN
ajst-28606	136	23	,	,	PUNCT
ajst-28606	136	24	huang	huang	PROPN
ajst-28606	136	25	,	,	PUNCT
ajst-28606	136	26	m.	m.	PROPN
ajst-28606	136	27	w.	w.	PROPN
ajst-28606	136	28	,	,	PUNCT
ajst-28606	136	29	kim	kim	PROPN
ajst-28606	136	30	,	,	PUNCT
ajst-28606	136	31	n.	n.	PROPN
ajst-28606	136	32	g.	g.	PROPN
ajst-28606	136	33	,	,	PUNCT
ajst-28606	136	34	yu	yu	PROPN
ajst-28606	136	35	,	,	PUNCT
ajst-28606	136	36	x.	x.	PROPN
ajst-28606	136	37	,	,	PUNCT
ajst-28606	136	38	li	li	PROPN
ajst-28606	136	39	,	,	PUNCT
ajst-28606	136	40	j.	j.	PROPN
ajst-28606	136	41	,	,	PUNCT
ajst-28606	136	42	walker	walker	PROPN
ajst-28606	136	43	,	,	PUNCT
ajst-28606	136	44	b.	b.	PROPN
ajst-28606	136	45	d.	d.	PROPN
ajst-28606	136	46	,	,	PUNCT
ajst-28606	136	47	greninger	greninger	NOUN
ajst-28606	136	48	,	,	PUNCT
ajst-28606	136	49	a.	a.	PROPN
ajst-28606	136	50	l.	l.	PROPN
ajst-28606	136	51	,	,	PUNCT
ajst-28606	136	52	jerome	jerome	PROPN
ajst-28606	136	53	,	,	PUNCT
ajst-28606	136	54	k.	k.	PROPN
ajst-28606	136	55	r.	r.	PROPN
ajst-28606	136	56	,	,	PUNCT
ajst-28606	136	57	gootenberg	gootenberg	PROPN
ajst-28606	136	58	,	,	PUNCT
ajst-28606	136	59	j.	j.	PROPN
ajst-28606	136	60	s.	s.	PROPN
ajst-28606	136	61	,	,	PUNCT
ajst-28606	136	62	abudayyeh	abudayyeh	PROPN
ajst-28606	136	63	,	,	PUNCT
ajst-28606	136	64	o.	o.	PROPN
ajst-28606	136	65	o.	o.	PROPN
ajst-28606	136	66	,	,	PUNCT
ajst-28606	136	67	&	&	CCONJ
ajst-28606	136	68	zhang	zhang	PROPN
ajst-28606	136	69	,	,	PUNCT
ajst-28606	136	70	f.	f.	PROPN
ajst-28606	136	71	(	(	PUNCT
ajst-28606	136	72	2020	2020	NUM
ajst-28606	136	73	)	)	PUNCT
ajst-28606	136	74	.	.	PUNCT
ajst-28606	137	1	point	point	NOUN
ajst-28606	137	2	-	-	PUNCT
ajst-28606	137	3	of	of	ADP
ajst-28606	137	4	-	-	PUNCT
ajst-28606	137	5	care	care	NOUN
ajst-28606	137	6	testing	testing	NOUN
ajst-28606	137	7	for	for	ADP
ajst-28606	137	8	covid-19	covid-19	PROPN
ajst-28606	137	9	using	use	VERB
ajst-28606	137	10	sherlock	sherlock	NOUN
ajst-28606	137	11	diagnostics	diagnostic	NOUN
ajst-28606	137	12	.	.	PUNCT
ajst-28606	138	1	medrxiv	medrxiv	X
ajst-28606	138	2	:	:	PUNCT
ajst-28606	138	3	the	the	DET
ajst-28606	138	4	preprint	preprint	NOUN
ajst-28606	138	5	server	server	NOUN
ajst-28606	138	6	for	for	ADP
ajst-28606	138	7	health	health	NOUN
ajst-28606	138	8	sciences	science	NOUN
ajst-28606	138	9	,	,	PUNCT
ajst-28606	138	10	2020.05.04.20091231	2020.05.04.20091231	NOUN
ajst-28606	138	11	.	.	PUNCT
ajst-28606	139	1	https://doi.org/10.1101/2020.05.04.20091231	https://doi.org/10.1101/2020.05.04.20091231	ADP
ajst-28606	139	2	[	[	X
ajst-28606	139	3	15	15	NUM
ajst-28606	139	4	]	]	X
ajst-28606	139	5	gootenberg	gootenberg	PROPN
ajst-28606	139	6	,	,	PUNCT
ajst-28606	139	7	j.	j.	PROPN
ajst-28606	139	8	s.	s.	PROPN
ajst-28606	139	9	,	,	PUNCT
ajst-28606	139	10	abudayyeh	abudayyeh	PROPN
ajst-28606	139	11	,	,	PUNCT
ajst-28606	139	12	o.	o.	PROPN
ajst-28606	139	13	o.	o.	PROPN
ajst-28606	139	14	,	,	PUNCT
ajst-28606	139	15	kellner	kellner	PROPN
ajst-28606	139	16	,	,	PUNCT
ajst-28606	139	17	m.	m.	PROPN
ajst-28606	139	18	j.	j.	PROPN
ajst-28606	139	19	,	,	PUNCT
ajst-28606	139	20	joung	joung	PROPN
ajst-28606	139	21	,	,	PUNCT
ajst-28606	139	22	j.	j.	PROPN
ajst-28606	139	23	,	,	PUNCT
ajst-28606	139	24	collins	collins	PROPN
ajst-28606	139	25	,	,	PUNCT
ajst-28606	139	26	j.	j.	PROPN
ajst-28606	139	27	j.	j.	PROPN
ajst-28606	139	28	,	,	PUNCT
ajst-28606	139	29	&	&	CCONJ
ajst-28606	139	30	zhang	zhang	PROPN
ajst-28606	139	31	,	,	PUNCT
ajst-28606	139	32	f.	f.	PROPN
ajst-28606	139	33	(	(	PUNCT
ajst-28606	139	34	2018	2018	NUM
ajst-28606	139	35	)	)	PUNCT
ajst-28606	139	36	.	.	PUNCT
ajst-28606	140	1	multiplexed	multiplexed	ADJ
ajst-28606	140	2	and	and	CCONJ
ajst-28606	140	3	portable	portable	ADJ
ajst-28606	140	4	nucleic	nucleic	ADJ
ajst-28606	140	5	acid	acid	NOUN
ajst-28606	140	6	detection	detection	NOUN
ajst-28606	140	7	platform	platform	NOUN
ajst-28606	140	8	with	with	ADP
ajst-28606	140	9	cas13	cas13	PROPN
ajst-28606	140	10	,	,	PUNCT
ajst-28606	140	11	cas12a	cas12a	NOUN
ajst-28606	140	12	,	,	PUNCT
ajst-28606	140	13	and	and	CCONJ
ajst-28606	140	14	csm6	csm6	NOUN
ajst-28606	140	15	.	.	PUNCT
ajst-28606	141	1	science	science	NOUN
ajst-28606	141	2	(	(	PUNCT
ajst-28606	141	3	new	new	PROPN
ajst-28606	141	4	york	york	PROPN
ajst-28606	141	5	,	,	PUNCT
ajst-28606	141	6	n.y	n.y	PROPN
ajst-28606	141	7	.	.	PROPN
ajst-28606	141	8	)	)	PUNCT
ajst-28606	141	9	,	,	PUNCT
ajst-28606	141	10	360(6387	360(6387	NUM
ajst-28606	141	11	)	)	PUNCT
ajst-28606	141	12	,	,	PUNCT
ajst-28606	141	13	439–444	439–444	NUM
ajst-28606	141	14	.	.	PUNCT
ajst-28606	142	1	https://doi.org/10.1126/science.aaq0179	https://doi.org/10.1126/science.aaq0179	X
ajst-28606	143	1	[	[	X
ajst-28606	143	2	16	16	NUM
ajst-28606	143	3	]	]	PUNCT
ajst-28606	143	4	rupp	rupp	PROPN
ajst-28606	143	5	,	,	PUNCT
ajst-28606	143	6	l.	l.	PROPN
ajst-28606	143	7	j.	j.	PROPN
ajst-28606	143	8	,	,	PUNCT
ajst-28606	143	9	schumann	schumann	PROPN
ajst-28606	143	10	,	,	PUNCT
ajst-28606	143	11	k.	k.	PROPN
ajst-28606	143	12	,	,	PUNCT
ajst-28606	143	13	roybal	roybal	PROPN
ajst-28606	143	14	,	,	PUNCT
ajst-28606	143	15	k.	k.	PROPN
ajst-28606	143	16	t.	t.	PROPN
ajst-28606	143	17	,	,	PUNCT
ajst-28606	143	18	gate	gate	PROPN
ajst-28606	143	19	,	,	PUNCT
ajst-28606	143	20	r.	r.	PROPN
ajst-28606	143	21	e.	e.	PROPN
ajst-28606	143	22	,	,	PUNCT
ajst-28606	143	23	ye	ye	PROPN
ajst-28606	143	24	,	,	PUNCT
ajst-28606	143	25	c.	c.	PROPN
ajst-28606	143	26	j.	j.	PROPN
ajst-28606	143	27	,	,	PUNCT
ajst-28606	143	28	lim	lim	PROPN
ajst-28606	143	29	,	,	PUNCT
ajst-28606	143	30	w.	w.	PROPN
ajst-28606	143	31	a.	a.	PROPN
ajst-28606	143	32	,	,	PUNCT
ajst-28606	143	33	&	&	CCONJ
ajst-28606	143	34	marson	marson	PROPN
ajst-28606	143	35	,	,	PUNCT
ajst-28606	143	36	a.	a.	NOUN
ajst-28606	143	37	(	(	PUNCT
ajst-28606	143	38	2017	2017	NUM
ajst-28606	143	39	)	)	PUNCT
ajst-28606	143	40	.	.	PUNCT
ajst-28606	144	1	crispr	crispr	PROPN
ajst-28606	144	2	/	/	SYM
ajst-28606	144	3	cas9	cas9	NOUN
ajst-28606	144	4	-	-	PUNCT
ajst-28606	144	5	mediated	mediate	VERB
ajst-28606	144	6	pd-1	pd-1	ADP
ajst-28606	144	7	disruption	disruption	NOUN
ajst-28606	144	8	enhances	enhance	VERB
ajst-28606	144	9	anti	anti	ADJ
ajst-28606	144	10	-	-	ADJ
ajst-28606	144	11	tumor	tumor	ADJ
ajst-28606	144	12	efficacy	efficacy	NOUN
ajst-28606	144	13	of	of	ADP
ajst-28606	144	14	human	human	ADJ
ajst-28606	144	15	chimeric	chimeric	ADJ
ajst-28606	144	16	antigen	antigen	ADJ
ajst-28606	144	17	receptor	receptor	NOUN
ajst-28606	144	18	t	t	NOUN
ajst-28606	144	19	cells	cell	NOUN
ajst-28606	144	20	.	.	PUNCT
ajst-28606	145	1	scientific	scientific	ADJ
ajst-28606	145	2	reports	report	NOUN
ajst-28606	145	3	,	,	PUNCT
ajst-28606	145	4	7(1	7(1	NUM
ajst-28606	145	5	)	)	PUNCT
ajst-28606	145	6	,	,	PUNCT
ajst-28606	145	7	737	737	NUM
ajst-28606	145	8	.	.	PUNCT
ajst-28606	145	9	https://doi.org/10.1038/s41598-017-00462-8	https://doi.org/10.1038/s41598-017-00462-8	PROPN
ajst-28606	146	1	[	[	X
ajst-28606	146	2	17	17	NUM
ajst-28606	146	3	]	]	X
ajst-28606	146	4	wang	wang	PROPN
ajst-28606	146	5	,	,	PUNCT
ajst-28606	146	6	t.	t.	PROPN
ajst-28606	146	7	,	,	PUNCT
ajst-28606	146	8	birsoy	birsoy	NOUN
ajst-28606	146	9	,	,	PUNCT
ajst-28606	146	10	k.	k.	PROPN
ajst-28606	146	11	,	,	PUNCT
ajst-28606	146	12	hughes	hughes	PROPN
ajst-28606	146	13	,	,	PUNCT
ajst-28606	146	14	n.	n.	PROPN
ajst-28606	146	15	w.	w.	PROPN
ajst-28606	146	16	,	,	PUNCT
ajst-28606	146	17	krupczak	krupczak	PROPN
ajst-28606	146	18	,	,	PUNCT
ajst-28606	146	19	k.	k.	PROPN
ajst-28606	146	20	m.	m.	PROPN
ajst-28606	146	21	,	,	PUNCT
ajst-28606	146	22	post	post	PROPN
ajst-28606	146	23	,	,	PUNCT
ajst-28606	146	24	y.	y.	PROPN
ajst-28606	146	25	,	,	PUNCT
ajst-28606	146	26	wei	wei	PROPN
ajst-28606	146	27	,	,	PUNCT
ajst-28606	146	28	j.	j.	PROPN
ajst-28606	146	29	j.	j.	PROPN
ajst-28606	146	30	,	,	PUNCT
ajst-28606	146	31	lander	lander	PROPN
ajst-28606	146	32	,	,	PUNCT
ajst-28606	146	33	e.	e.	PROPN
ajst-28606	146	34	s.	s.	PROPN
ajst-28606	146	35	,	,	PUNCT
ajst-28606	146	36	&	&	CCONJ
ajst-28606	146	37	sabatini	sabatini	PROPN
ajst-28606	146	38	,	,	PUNCT
ajst-28606	146	39	d.	d.	PROPN
ajst-28606	146	40	m.	m.	PROPN
ajst-28606	146	41	(	(	PUNCT
ajst-28606	146	42	2015	2015	NUM
ajst-28606	146	43	)	)	PUNCT
ajst-28606	146	44	.	.	PUNCT
ajst-28606	147	1	identification	identification	NOUN
ajst-28606	147	2	and	and	CCONJ
ajst-28606	147	3	characterization	characterization	NOUN
ajst-28606	147	4	of	of	ADP
ajst-28606	147	5	essential	essential	ADJ
ajst-28606	147	6	genes	gene	NOUN
ajst-28606	147	7	in	in	ADP
ajst-28606	147	8	the	the	DET
ajst-28606	147	9	human	human	ADJ
ajst-28606	147	10	genome	genome	NOUN
ajst-28606	147	11	.	.	PUNCT
ajst-28606	148	1	science	science	NOUN
ajst-28606	148	2	(	(	PUNCT
ajst-28606	148	3	new	new	PROPN
ajst-28606	148	4	york	york	PROPN
ajst-28606	148	5	,	,	PUNCT
ajst-28606	148	6	n.y	n.y	PROPN
ajst-28606	148	7	.	.	PROPN
ajst-28606	148	8	)	)	PUNCT
ajst-28606	148	9	,	,	PUNCT
ajst-28606	148	10	350(6264	350(6264	NOUN
ajst-28606	148	11	)	)	PUNCT
ajst-28606	148	12	,	,	PUNCT
ajst-28606	148	13	1096	1096	NUM
ajst-28606	148	14	–	–	PUNCT
ajst-28606	148	15	1101	1101	NUM
ajst-28606	148	16	.	.	PUNCT
ajst-28606	149	1	https://doi.org/10.1126/science.aac7041	https://doi.org/10.1126/science.aac7041	PROPN