id	sid	tid	token	lemma	pos
ajst-31202	1	1	academic	academic	ADJ
ajst-31202	1	2	journal	journal	NOUN
ajst-31202	1	3	of	of	ADP
ajst-31202	1	4	science	science	NOUN
ajst-31202	1	5	and	and	CCONJ
ajst-31202	1	6	technology	technology	NOUN
ajst-31202	1	7	issn	issn	NOUN
ajst-31202	1	8	:	:	PUNCT
ajst-31202	1	9	2771	2771	NUM
ajst-31202	1	10	-	-	SYM
ajst-31202	1	11	3032	3032	NUM
ajst-31202	1	12	|	|	NOUN
ajst-31202	1	13	vol	vol	NOUN
ajst-31202	1	14	.	.	PROPN
ajst-31202	1	15	15	15	NUM
ajst-31202	1	16	,	,	PUNCT
ajst-31202	1	17	no	no	INTJ
ajst-31202	1	18	.	.	NOUN
ajst-31202	1	19	3	3	NUM
ajst-31202	1	20	,	,	PUNCT
ajst-31202	1	21	2025	2025	NUM
ajst-31202	1	22	50	50	NUM
ajst-31202	1	23	emerging	emerge	VERB
ajst-31202	1	24	insights	insight	NOUN
ajst-31202	1	25	into	into	ADP
ajst-31202	1	26	the	the	DET
ajst-31202	1	27	principles	principle	NOUN
ajst-31202	1	28	and	and	CCONJ
ajst-31202	1	29	advantages	advantage	NOUN
ajst-31202	1	30	of	of	ADP
ajst-31202	1	31	single	single	ADJ
ajst-31202	1	32	-	-	PUNCT
ajst-31202	1	33	cell	cell	NOUN
ajst-31202	1	34	and	and	CCONJ
ajst-31202	1	35	spatial	spatial	ADJ
ajst-31202	1	36	transcriptomics	transcriptomic	NOUN
ajst-31202	1	37	boyu	boyu	VERB
ajst-31202	1	38	zhu	zhu	PROPN
ajst-31202	1	39	school	school	PROPN
ajst-31202	1	40	of	of	ADP
ajst-31202	1	41	marine	marine	PROPN
ajst-31202	1	42	sciences	sciences	PROPN
ajst-31202	1	43	,	,	PUNCT
ajst-31202	1	44	sun	sun	PROPN
ajst-31202	1	45	yat	yat	PROPN
ajst-31202	1	46	-	-	PUNCT
ajst-31202	1	47	sen	sen	PROPN
ajst-31202	1	48	university	university	PROPN
ajst-31202	1	49	,	,	PUNCT
ajst-31202	1	50	zhuhai	zhuhai	PROPN
ajst-31202	1	51	,	,	PUNCT
ajst-31202	1	52	china	china	PROPN
ajst-31202	1	53	abstract	abstract	ADJ
ajst-31202	1	54	:	:	PUNCT
ajst-31202	1	55	single	single	ADJ
ajst-31202	1	56	-	-	PUNCT
ajst-31202	1	57	cell	cell	NOUN
ajst-31202	1	58	transcriptomics	transcriptomic	NOUN
ajst-31202	1	59	is	be	AUX
ajst-31202	1	60	a	a	DET
ajst-31202	1	61	high	high	ADJ
ajst-31202	1	62	-	-	PUNCT
ajst-31202	1	63	throughput	throughput	NOUN
ajst-31202	1	64	technology	technology	NOUN
ajst-31202	1	65	capable	capable	ADJ
ajst-31202	1	66	of	of	ADP
ajst-31202	1	67	analyzing	analyze	VERB
ajst-31202	1	68	gene	gene	NOUN
ajst-31202	1	69	expression	expression	NOUN
ajst-31202	1	70	at	at	ADP
ajst-31202	1	71	the	the	DET
ajst-31202	1	72	individual	individual	ADJ
ajst-31202	1	73	cell	cell	NOUN
ajst-31202	1	74	level	level	NOUN
ajst-31202	1	75	.	.	PUNCT
ajst-31202	2	1	spatial	spatial	ADJ
ajst-31202	2	2	transcriptomics	transcriptomic	NOUN
ajst-31202	2	3	,	,	PUNCT
ajst-31202	2	4	on	on	ADP
ajst-31202	2	5	the	the	DET
ajst-31202	2	6	other	other	ADJ
ajst-31202	2	7	hand	hand	NOUN
ajst-31202	2	8	,	,	PUNCT
ajst-31202	2	9	is	be	AUX
ajst-31202	2	10	a	a	DET
ajst-31202	2	11	technique	technique	NOUN
ajst-31202	2	12	that	that	PRON
ajst-31202	2	13	simultaneously	simultaneously	ADV
ajst-31202	2	14	captures	capture	VERB
ajst-31202	2	15	both	both	DET
ajst-31202	2	16	gene	gene	NOUN
ajst-31202	2	17	expression	expression	NOUN
ajst-31202	2	18	profiles	profile	NOUN
ajst-31202	2	19	and	and	CCONJ
ajst-31202	2	20	the	the	DET
ajst-31202	2	21	spatial	spatial	ADJ
ajst-31202	2	22	location	location	NOUN
ajst-31202	2	23	information	information	NOUN
ajst-31202	2	24	of	of	ADP
ajst-31202	2	25	cells	cell	NOUN
ajst-31202	2	26	.	.	PUNCT
ajst-31202	3	1	while	while	SCONJ
ajst-31202	3	2	single	single	ADJ
ajst-31202	3	3	-	-	PUNCT
ajst-31202	3	4	cell	cell	NOUN
ajst-31202	3	5	transcriptomics	transcriptomic	NOUN
ajst-31202	3	6	enables	enable	VERB
ajst-31202	3	7	sequencing	sequence	VERB
ajst-31202	3	8	of	of	ADP
ajst-31202	3	9	the	the	DET
ajst-31202	3	10	transcriptome	transcriptome	NOUN
ajst-31202	3	11	at	at	ADP
ajst-31202	3	12	a	a	DET
ajst-31202	3	13	single	single	ADJ
ajst-31202	3	14	-	-	PUNCT
ajst-31202	3	15	cell	cell	NOUN
ajst-31202	3	16	resolution	resolution	NOUN
ajst-31202	3	17	,	,	PUNCT
ajst-31202	3	18	spatial	spatial	ADJ
ajst-31202	3	19	transcriptomics	transcriptomic	NOUN
ajst-31202	3	20	provides	provide	VERB
ajst-31202	3	21	the	the	DET
ajst-31202	3	22	added	add	VERB
ajst-31202	3	23	dimension	dimension	NOUN
ajst-31202	3	24	of	of	ADP
ajst-31202	3	25	spatial	spatial	ADJ
ajst-31202	3	26	context	context	NOUN
ajst-31202	3	27	alongside	alongside	ADP
ajst-31202	3	28	gene	gene	NOUN
ajst-31202	3	29	expression	expression	NOUN
ajst-31202	3	30	data	datum	NOUN
ajst-31202	3	31	.	.	PUNCT
ajst-31202	4	1	these	these	DET
ajst-31202	4	2	two	two	NUM
ajst-31202	4	3	approaches	approach	NOUN
ajst-31202	4	4	single	single	ADJ
ajst-31202	4	5	-	-	PUNCT
ajst-31202	4	6	cell	cell	NOUN
ajst-31202	4	7	transcriptomics	transcriptomic	NOUN
ajst-31202	4	8	and	and	CCONJ
ajst-31202	4	9	spatial	spatial	ADJ
ajst-31202	4	10	transcriptomics	transcriptomic	NOUN
ajst-31202	4	11	are	be	AUX
ajst-31202	4	12	complementary	complementary	ADJ
ajst-31202	4	13	,	,	PUNCT
ajst-31202	4	14	and	and	CCONJ
ajst-31202	4	15	their	their	PRON
ajst-31202	4	16	integration	integration	NOUN
ajst-31202	4	17	can	can	AUX
ajst-31202	4	18	facilitate	facilitate	VERB
ajst-31202	4	19	a	a	DET
ajst-31202	4	20	more	more	ADV
ajst-31202	4	21	comprehensive	comprehensive	ADJ
ajst-31202	4	22	and	and	CCONJ
ajst-31202	4	23	in	in	ADP
ajst-31202	4	24	-	-	PUNCT
ajst-31202	4	25	depth	depth	NOUN
ajst-31202	4	26	investigation	investigation	NOUN
ajst-31202	4	27	of	of	ADP
ajst-31202	4	28	biological	biological	ADJ
ajst-31202	4	29	questions	question	NOUN
ajst-31202	4	30	.	.	PUNCT
ajst-31202	5	1	keywords	keyword	NOUN
ajst-31202	5	2	:	:	PUNCT
ajst-31202	5	3	single	single	ADJ
ajst-31202	5	4	-	-	PUNCT
ajst-31202	5	5	cell	cell	NOUN
ajst-31202	5	6	transcriptome	transcriptome	ADJ
ajst-31202	5	7	sequencing	sequencing	NOUN
ajst-31202	5	8	;	;	PUNCT
ajst-31202	5	9	high	high	ADJ
ajst-31202	5	10	-	-	PUNCT
ajst-31202	5	11	throughput	throughput	NOUN
ajst-31202	5	12	analysis	analysis	NOUN
ajst-31202	5	13	;	;	PUNCT
ajst-31202	5	14	spatial	spatial	ADJ
ajst-31202	5	15	transcriptome	transcriptome	ADJ
ajst-31202	5	16	sequencing	sequencing	NOUN
ajst-31202	5	17	;	;	PUNCT
ajst-31202	5	18	spatial	spatial	ADJ
ajst-31202	5	19	location	location	NOUN
ajst-31202	5	20	information	information	NOUN
ajst-31202	5	21	;	;	PUNCT
ajst-31202	5	22	cell	cell	NOUN
ajst-31202	5	23	transcriptome	transcriptome	NOUN
ajst-31202	5	24	.	.	PUNCT
ajst-31202	6	1	1	1	X
ajst-31202	6	2	.	.	X
ajst-31202	6	3	introduction	introduction	NOUN
ajst-31202	6	4	single	single	ADJ
ajst-31202	6	5	-	-	PUNCT
ajst-31202	6	6	cell	cell	NOUN
ajst-31202	6	7	rna	rna	NOUN
ajst-31202	6	8	sequencing	sequence	VERB
ajst-31202	6	9	(	(	PUNCT
ajst-31202	6	10	scrna	scrna	NOUN
ajst-31202	6	11	-	-	PUNCT
ajst-31202	6	12	seq	seq	NOUN
ajst-31202	6	13	)	)	PUNCT
ajst-31202	6	14	is	be	AUX
ajst-31202	6	15	a	a	DET
ajst-31202	6	16	powerful	powerful	ADJ
ajst-31202	6	17	technique	technique	NOUN
ajst-31202	6	18	that	that	PRON
ajst-31202	6	19	enables	enable	VERB
ajst-31202	6	20	the	the	DET
ajst-31202	6	21	analysis	analysis	NOUN
ajst-31202	6	22	of	of	ADP
ajst-31202	6	23	gene	gene	NOUN
ajst-31202	6	24	expression	expression	NOUN
ajst-31202	6	25	at	at	ADP
ajst-31202	6	26	the	the	DET
ajst-31202	6	27	resolution	resolution	NOUN
ajst-31202	6	28	of	of	ADP
ajst-31202	6	29	individual	individual	ADJ
ajst-31202	6	30	cells	cell	NOUN
ajst-31202	6	31	.	.	PUNCT
ajst-31202	7	1	by	by	ADP
ajst-31202	7	2	isolating	isolate	VERB
ajst-31202	7	3	,	,	PUNCT
ajst-31202	7	4	labeling	labeling	NOUN
ajst-31202	7	5	,	,	PUNCT
ajst-31202	7	6	sorting	sorting	NOUN
ajst-31202	7	7	,	,	PUNCT
ajst-31202	7	8	lysing	lysing	NOUN
ajst-31202	7	9	,	,	PUNCT
ajst-31202	7	10	reverse	reverse	ADJ
ajst-31202	7	11	transcribing	transcribing	NOUN
ajst-31202	7	12	,	,	PUNCT
ajst-31202	7	13	and	and	CCONJ
ajst-31202	7	14	sequencing	sequence	VERB
ajst-31202	7	15	cells	cell	NOUN
ajst-31202	7	16	from	from	ADP
ajst-31202	7	17	a	a	DET
ajst-31202	7	18	tissue	tissue	NOUN
ajst-31202	7	19	,	,	PUNCT
ajst-31202	7	20	scrna	scrna	NOUN
ajst-31202	7	21	-	-	PUNCT
ajst-31202	7	22	seq	seq	NOUN
ajst-31202	7	23	constructs	construct	NOUN
ajst-31202	7	24	high	high	ADJ
ajst-31202	7	25	-	-	PUNCT
ajst-31202	7	26	resolution	resolution	NOUN
ajst-31202	7	27	gene	gene	NOUN
ajst-31202	7	28	expression	expression	NOUN
ajst-31202	7	29	profiles	profile	NOUN
ajst-31202	7	30	at	at	ADP
ajst-31202	7	31	the	the	DET
ajst-31202	7	32	single	single	ADJ
ajst-31202	7	33	-	-	PUNCT
ajst-31202	7	34	cell	cell	NOUN
ajst-31202	7	35	level	level	NOUN
ajst-31202	7	36	.	.	PUNCT
ajst-31202	8	1	this	this	PRON
ajst-31202	8	2	allows	allow	VERB
ajst-31202	8	3	for	for	ADP
ajst-31202	8	4	the	the	DET
ajst-31202	8	5	identification	identification	NOUN
ajst-31202	8	6	of	of	ADP
ajst-31202	8	7	distinct	distinct	ADJ
ajst-31202	8	8	cell	cell	NOUN
ajst-31202	8	9	types	type	NOUN
ajst-31202	8	10	,	,	PUNCT
ajst-31202	8	11	functional	functional	ADJ
ajst-31202	8	12	states	state	NOUN
ajst-31202	8	13	,	,	PUNCT
ajst-31202	8	14	subpopulation	subpopulation	ADJ
ajst-31202	8	15	heterogeneity	heterogeneity	NOUN
ajst-31202	8	16	,	,	PUNCT
ajst-31202	8	17	and	and	CCONJ
ajst-31202	8	18	dynamic	dynamic	ADJ
ajst-31202	8	19	transitions	transition	NOUN
ajst-31202	8	20	[	[	X
ajst-31202	8	21	1	1	NUM
ajst-31202	8	22	]	]	PUNCT
ajst-31202	8	23	.	.	PUNCT
ajst-31202	9	1	additionally	additionally	ADV
ajst-31202	9	2	,	,	PUNCT
ajst-31202	9	3	scrna	scrna	NOUN
ajst-31202	9	4	-	-	PUNCT
ajst-31202	9	5	seq	seq	NOUN
ajst-31202	9	6	can	can	AUX
ajst-31202	9	7	detect	detect	VERB
ajst-31202	9	8	transcript	transcript	NOUN
ajst-31202	9	9	isoforms	isoform	NOUN
ajst-31202	9	10	,	,	PUNCT
ajst-31202	9	11	such	such	ADJ
ajst-31202	9	12	as	as	ADP
ajst-31202	9	13	alternative	alternative	ADJ
ajst-31202	9	14	splicing	splicing	NOUN
ajst-31202	9	15	events	event	NOUN
ajst-31202	9	16	,	,	PUNCT
ajst-31202	9	17	offering	offer	VERB
ajst-31202	9	18	critical	critical	ADJ
ajst-31202	9	19	insights	insight	NOUN
ajst-31202	9	20	into	into	ADP
ajst-31202	9	21	gene	gene	NOUN
ajst-31202	9	22	regulatory	regulatory	ADJ
ajst-31202	9	23	mechanisms	mechanism	NOUN
ajst-31202	9	24	.	.	PUNCT
ajst-31202	10	1	it	it	PRON
ajst-31202	10	2	is	be	AUX
ajst-31202	10	3	particularly	particularly	ADV
ajst-31202	10	4	well	well	ADV
ajst-31202	10	5	-	-	PUNCT
ajst-31202	10	6	suited	suited	ADJ
ajst-31202	10	7	for	for	ADP
ajst-31202	10	8	identifying	identify	VERB
ajst-31202	10	9	rare	rare	ADJ
ajst-31202	10	10	or	or	CCONJ
ajst-31202	10	11	novel	novel	ADJ
ajst-31202	10	12	cell	cell	NOUN
ajst-31202	10	13	types	type	NOUN
ajst-31202	10	14	that	that	PRON
ajst-31202	10	15	are	be	AUX
ajst-31202	10	16	difficult	difficult	ADJ
ajst-31202	10	17	to	to	PART
ajst-31202	10	18	capture	capture	VERB
ajst-31202	10	19	using	use	VERB
ajst-31202	10	20	traditional	traditional	ADJ
ajst-31202	10	21	bulk	bulk	ADJ
ajst-31202	10	22	rna	rna	NOUN
ajst-31202	10	23	-	-	PUNCT
ajst-31202	10	24	sequencing	sequence	VERB
ajst-31202	10	25	methods	method	NOUN
ajst-31202	10	26	.	.	PUNCT
ajst-31202	11	1	however	however	ADV
ajst-31202	11	2	,	,	PUNCT
ajst-31202	11	3	scrna	scrna	NOUN
ajst-31202	11	4	-	-	PUNCT
ajst-31202	11	5	seq	seq	NOUN
ajst-31202	11	6	has	have	VERB
ajst-31202	11	7	certain	certain	ADJ
ajst-31202	11	8	limitations	limitation	NOUN
ajst-31202	11	9	.	.	PUNCT
ajst-31202	12	1	for	for	ADP
ajst-31202	12	2	instance	instance	NOUN
ajst-31202	12	3	,	,	PUNCT
ajst-31202	12	4	spatial	spatial	ADJ
ajst-31202	12	5	information	information	NOUN
ajst-31202	12	6	is	be	AUX
ajst-31202	12	7	lost	lose	VERB
ajst-31202	12	8	during	during	ADP
ajst-31202	12	9	cell	cell	NOUN
ajst-31202	12	10	dissociation	dissociation	NOUN
ajst-31202	12	11	,	,	PUNCT
ajst-31202	12	12	making	make	VERB
ajst-31202	12	13	it	it	PRON
ajst-31202	12	14	difficult	difficult	ADJ
ajst-31202	12	15	to	to	PART
ajst-31202	12	16	reconstruct	reconstruct	VERB
ajst-31202	12	17	the	the	DET
ajst-31202	12	18	original	original	ADJ
ajst-31202	12	19	tissue	tissue	NOUN
ajst-31202	12	20	context	context	NOUN
ajst-31202	12	21	.	.	PUNCT
ajst-31202	13	1	furthermore	furthermore	ADV
ajst-31202	13	2	,	,	PUNCT
ajst-31202	13	3	the	the	DET
ajst-31202	13	4	technique	technique	NOUN
ajst-31202	13	5	is	be	AUX
ajst-31202	13	6	costly	costly	ADJ
ajst-31202	13	7	,	,	PUNCT
ajst-31202	13	8	prone	prone	ADJ
ajst-31202	13	9	to	to	ADP
ajst-31202	13	10	high	high	ADJ
ajst-31202	13	11	levels	level	NOUN
ajst-31202	13	12	of	of	ADP
ajst-31202	13	13	technical	technical	ADJ
ajst-31202	13	14	noise	noise	NOUN
ajst-31202	13	15	,	,	PUNCT
ajst-31202	13	16	and	and	CCONJ
ajst-31202	13	17	requires	require	VERB
ajst-31202	13	18	complex	complex	ADJ
ajst-31202	13	19	computational	computational	ADJ
ajst-31202	13	20	analysis	analysis	NOUN
ajst-31202	13	21	[	[	X
ajst-31202	13	22	2	2	NUM
ajst-31202	13	23	]	]	PUNCT
ajst-31202	13	24	,	,	PUNCT
ajst-31202	13	25	posing	pose	VERB
ajst-31202	13	26	significant	significant	ADJ
ajst-31202	13	27	challenges	challenge	NOUN
ajst-31202	13	28	for	for	ADP
ajst-31202	13	29	experimental	experimental	ADJ
ajst-31202	13	30	design	design	NOUN
ajst-31202	13	31	and	and	CCONJ
ajst-31202	13	32	data	datum	NOUN
ajst-31202	13	33	interpretation	interpretation	NOUN
ajst-31202	13	34	.	.	PUNCT
ajst-31202	14	1	to	to	PART
ajst-31202	14	2	address	address	VERB
ajst-31202	14	3	the	the	DET
ajst-31202	14	4	lack	lack	NOUN
ajst-31202	14	5	of	of	ADP
ajst-31202	14	6	spatial	spatial	ADJ
ajst-31202	14	7	context	context	NOUN
ajst-31202	14	8	in	in	ADP
ajst-31202	14	9	scrna	scrna	NOUN
ajst-31202	14	10	-	-	PUNCT
ajst-31202	14	11	seq	seq	NOUN
ajst-31202	14	12	,	,	PUNCT
ajst-31202	14	13	spatial	spatial	ADJ
ajst-31202	14	14	transcriptomics	transcriptomic	NOUN
ajst-31202	14	15	(	(	PUNCT
ajst-31202	14	16	st	st	NOUN
ajst-31202	14	17	)	)	PUNCT
ajst-31202	14	18	technologies	technology	NOUN
ajst-31202	14	19	have	have	AUX
ajst-31202	14	20	emerged	emerge	VERB
ajst-31202	14	21	.	.	PUNCT
ajst-31202	15	1	these	these	DET
ajst-31202	15	2	methods	method	NOUN
ajst-31202	15	3	preserve	preserve	VERB
ajst-31202	15	4	the	the	DET
ajst-31202	15	5	tissue	tissue	NOUN
ajst-31202	15	6	architecture	architecture	NOUN
ajst-31202	15	7	while	while	SCONJ
ajst-31202	15	8	fixing	fix	VERB
ajst-31202	15	9	,	,	PUNCT
ajst-31202	15	10	permeabilizing	permeabilizing	NOUN
ajst-31202	15	11	,	,	PUNCT
ajst-31202	15	12	and	and	CCONJ
ajst-31202	15	13	sequencing	sequence	VERB
ajst-31202	15	14	tissue	tissue	NOUN
ajst-31202	15	15	sections	section	NOUN
ajst-31202	15	16	.	.	PUNCT
ajst-31202	16	1	through	through	ADP
ajst-31202	16	2	spatial	spatial	ADJ
ajst-31202	16	3	barcoding	barcoding	NOUN
ajst-31202	16	4	or	or	CCONJ
ajst-31202	16	5	probe	probe	NOUN
ajst-31202	16	6	-	-	PUNCT
ajst-31202	16	7	based	base	VERB
ajst-31202	16	8	strategies	strategy	NOUN
ajst-31202	16	9	,	,	PUNCT
ajst-31202	16	10	st	st	PROPN
ajst-31202	16	11	maps	maps	PROPN
ajst-31202	16	12	rna	rna	NOUN
ajst-31202	16	13	molecules	molecule	NOUN
ajst-31202	16	14	to	to	ADP
ajst-31202	16	15	their	their	PRON
ajst-31202	16	16	spatial	spatial	ADJ
ajst-31202	16	17	locations	location	NOUN
ajst-31202	16	18	,	,	PUNCT
ajst-31202	16	19	thereby	thereby	ADV
ajst-31202	16	20	enabling	enable	VERB
ajst-31202	16	21	transcriptome	transcriptome	NOUN
ajst-31202	16	22	-	-	PUNCT
ajst-31202	16	23	wide	wide	ADJ
ajst-31202	16	24	spatial	spatial	ADJ
ajst-31202	16	25	gene	gene	NOUN
ajst-31202	16	26	expression	expression	NOUN
ajst-31202	16	27	profiling	profiling	NOUN
ajst-31202	16	28	.	.	PUNCT
ajst-31202	17	1	st	st	PROPN
ajst-31202	17	2	reveals	reveal	VERB
ajst-31202	17	3	how	how	SCONJ
ajst-31202	17	4	cells	cell	NOUN
ajst-31202	17	5	are	be	AUX
ajst-31202	17	6	organized	organize	VERB
ajst-31202	17	7	within	within	ADP
ajst-31202	17	8	the	the	DET
ajst-31202	17	9	tissue	tissue	NOUN
ajst-31202	17	10	microenvironment	microenvironment	NOUN
ajst-31202	17	11	,	,	PUNCT
ajst-31202	17	12	their	their	PRON
ajst-31202	17	13	interactions	interaction	NOUN
ajst-31202	17	14	,	,	PUNCT
ajst-31202	17	15	and	and	CCONJ
ajst-31202	17	16	functional	functional	ADJ
ajst-31202	17	17	states	state	NOUN
ajst-31202	17	18	.	.	PUNCT
ajst-31202	18	1	while	while	SCONJ
ajst-31202	18	2	st	st	PROPN
ajst-31202	18	3	retains	retain	VERB
ajst-31202	18	4	spatial	spatial	ADJ
ajst-31202	18	5	information	information	NOUN
ajst-31202	18	6	,	,	PUNCT
ajst-31202	18	7	its	its	PRON
ajst-31202	18	8	spatial	spatial	ADJ
ajst-31202	18	9	resolution	resolution	NOUN
ajst-31202	18	10	is	be	AUX
ajst-31202	18	11	limited	limit	VERB
ajst-31202	18	12	each	each	DET
ajst-31202	18	13	capture	capture	NOUN
ajst-31202	18	14	spot	spot	NOUN
ajst-31202	18	15	may	may	AUX
ajst-31202	18	16	represent	represent	VERB
ajst-31202	18	17	transcripts	transcript	NOUN
ajst-31202	18	18	from	from	ADP
ajst-31202	18	19	multiple	multiple	ADJ
ajst-31202	18	20	cells	cell	NOUN
ajst-31202	18	21	making	make	VERB
ajst-31202	18	22	it	it	PRON
ajst-31202	18	23	challenging	challenging	ADJ
ajst-31202	18	24	to	to	PART
ajst-31202	18	25	resolve	resolve	VERB
ajst-31202	18	26	expression	expression	NOUN
ajst-31202	18	27	patterns	pattern	NOUN
ajst-31202	18	28	at	at	ADP
ajst-31202	18	29	true	true	ADJ
ajst-31202	18	30	single	single	ADJ
ajst-31202	18	31	-	-	PUNCT
ajst-31202	18	32	cell	cell	NOUN
ajst-31202	18	33	resolution	resolution	NOUN
ajst-31202	18	34	.	.	PUNCT
ajst-31202	19	1	in	in	ADP
ajst-31202	19	2	addition	addition	NOUN
ajst-31202	19	3	,	,	PUNCT
ajst-31202	19	4	st	st	PROPN
ajst-31202	19	5	generally	generally	ADV
ajst-31202	19	6	exhibits	exhibit	VERB
ajst-31202	19	7	lower	low	ADJ
ajst-31202	19	8	sensitivity	sensitivity	NOUN
ajst-31202	19	9	for	for	ADP
ajst-31202	19	10	detecting	detect	VERB
ajst-31202	19	11	low	low	ADJ
ajst-31202	19	12	-	-	PUNCT
ajst-31202	19	13	abundance	abundance	NOUN
ajst-31202	19	14	transcripts	transcript	NOUN
ajst-31202	19	15	[	[	X
ajst-31202	19	16	3	3	NUM
ajst-31202	19	17	]	]	PUNCT
ajst-31202	19	18	.	.	PUNCT
ajst-31202	20	1	data	datum	NOUN
ajst-31202	20	2	integration	integration	NOUN
ajst-31202	20	3	and	and	CCONJ
ajst-31202	20	4	analysis	analysis	NOUN
ajst-31202	20	5	in	in	ADP
ajst-31202	20	6	st	st	PROPN
ajst-31202	20	7	also	also	ADV
ajst-31202	20	8	remain	remain	VERB
ajst-31202	20	9	nontrivial	nontrivial	ADJ
ajst-31202	20	10	,	,	PUNCT
ajst-31202	20	11	particularly	particularly	ADV
ajst-31202	20	12	when	when	SCONJ
ajst-31202	20	13	aligning	align	VERB
ajst-31202	20	14	and	and	CCONJ
ajst-31202	20	15	fusing	fuse	VERB
ajst-31202	20	16	st	st	PROPN
ajst-31202	20	17	data	datum	NOUN
ajst-31202	20	18	with	with	ADP
ajst-31202	20	19	other	other	ADJ
ajst-31202	20	20	modalities	modality	NOUN
ajst-31202	20	21	such	such	ADJ
ajst-31202	20	22	as	as	ADP
ajst-31202	20	23	scrna	scrna	NOUN
ajst-31202	20	24	-	-	PUNCT
ajst-31202	20	25	seq	seq	NOUN
ajst-31202	20	26	.	.	PUNCT
ajst-31202	21	1	despite	despite	SCONJ
ajst-31202	21	2	their	their	PRON
ajst-31202	21	3	individual	individual	ADJ
ajst-31202	21	4	limitations	limitation	NOUN
ajst-31202	21	5	,	,	PUNCT
ajst-31202	21	6	both	both	DET
ajst-31202	21	7	scrna	scrna	NOUN
ajst-31202	21	8	-	-	PUNCT
ajst-31202	21	9	seq	seq	NOUN
ajst-31202	21	10	and	and	CCONJ
ajst-31202	21	11	st	st	PROPN
ajst-31202	21	12	rely	rely	PROPN
ajst-31202	21	13	on	on	ADP
ajst-31202	21	14	high	high	ADJ
ajst-31202	21	15	-	-	PUNCT
ajst-31202	21	16	throughput	throughput	NOUN
ajst-31202	21	17	mrna	mrna	NOUN
ajst-31202	21	18	sequencing	sequence	VERB
ajst-31202	21	19	to	to	PART
ajst-31202	21	20	generate	generate	VERB
ajst-31202	21	21	largescale	largescale	ADJ
ajst-31202	21	22	gene	gene	NOUN
ajst-31202	21	23	expression	expression	NOUN
ajst-31202	21	24	datasets	dataset	NOUN
ajst-31202	21	25	.	.	PUNCT
ajst-31202	22	1	when	when	SCONJ
ajst-31202	22	2	combined	combine	VERB
ajst-31202	22	3	with	with	ADP
ajst-31202	22	4	computational	computational	ADJ
ajst-31202	22	5	tools	tool	NOUN
ajst-31202	22	6	such	such	ADJ
ajst-31202	22	7	as	as	ADP
ajst-31202	22	8	clustering	cluster	VERB
ajst-31202	22	9	analysis	analysis	NOUN
ajst-31202	22	10	and	and	CCONJ
ajst-31202	22	11	pseudotime	pseudotime	NOUN
ajst-31202	22	12	inference	inference	NOUN
ajst-31202	22	13	,	,	PUNCT
ajst-31202	22	14	these	these	DET
ajst-31202	22	15	methods	method	NOUN
ajst-31202	22	16	can	can	AUX
ajst-31202	22	17	reveal	reveal	VERB
ajst-31202	22	18	cellular	cellular	ADJ
ajst-31202	22	19	developmental	developmental	ADJ
ajst-31202	22	20	trajectories	trajectory	NOUN
ajst-31202	22	21	and	and	CCONJ
ajst-31202	22	22	state	state	NOUN
ajst-31202	22	23	transitions	transition	NOUN
ajst-31202	22	24	[	[	X
ajst-31202	22	25	4	4	NUM
ajst-31202	22	26	]	]	PUNCT
ajst-31202	22	27	.	.	PUNCT
ajst-31202	23	1	integrating	integrate	VERB
ajst-31202	23	2	scrna	scrna	NOUN
ajst-31202	23	3	-	-	PUNCT
ajst-31202	23	4	seq	seq	NOUN
ajst-31202	23	5	with	with	ADP
ajst-31202	23	6	st	st	PROPN
ajst-31202	23	7	has	have	AUX
ajst-31202	23	8	become	become	VERB
ajst-31202	23	9	a	a	DET
ajst-31202	23	10	powerful	powerful	ADJ
ajst-31202	23	11	strategy	strategy	NOUN
ajst-31202	23	12	for	for	ADP
ajst-31202	23	13	dissecting	dissect	VERB
ajst-31202	23	14	complex	complex	ADJ
ajst-31202	23	15	tissue	tissue	NOUN
ajst-31202	23	16	architectures	architecture	NOUN
ajst-31202	23	17	and	and	CCONJ
ajst-31202	23	18	functions	function	NOUN
ajst-31202	23	19	.	.	PUNCT
ajst-31202	24	1	by	by	ADP
ajst-31202	24	2	aligning	align	VERB
ajst-31202	24	3	datasets	dataset	NOUN
ajst-31202	24	4	,	,	PUNCT
ajst-31202	24	5	performing	perform	VERB
ajst-31202	24	6	spatial	spatial	ADJ
ajst-31202	24	7	mapping	mapping	NOUN
ajst-31202	24	8	,	,	PUNCT
ajst-31202	24	9	and	and	CCONJ
ajst-31202	24	10	applying	apply	VERB
ajst-31202	24	11	joint	joint	ADJ
ajst-31202	24	12	modeling	modeling	NOUN
ajst-31202	24	13	approaches	approach	NOUN
ajst-31202	24	14	,	,	PUNCT
ajst-31202	24	15	researchers	researcher	NOUN
ajst-31202	24	16	can	can	AUX
ajst-31202	24	17	localize	localize	VERB
ajst-31202	24	18	single	single	ADJ
ajst-31202	24	19	-	-	PUNCT
ajst-31202	24	20	cell	cell	NOUN
ajst-31202	24	21	subpopulations	subpopulation	NOUN
ajst-31202	24	22	within	within	ADP
ajst-31202	24	23	tissues	tissue	NOUN
ajst-31202	24	24	and	and	CCONJ
ajst-31202	24	25	annotate	annotate	VERB
ajst-31202	24	26	their	their	PRON
ajst-31202	24	27	functions	function	NOUN
ajst-31202	24	28	with	with	ADP
ajst-31202	24	29	high	high	ADJ
ajst-31202	24	30	resolution	resolution	NOUN
ajst-31202	24	31	and	and	CCONJ
ajst-31202	24	32	biological	biological	ADJ
ajst-31202	24	33	interpretability	interpretability	NOUN
ajst-31202	24	34	.	.	PUNCT
ajst-31202	25	1	for	for	ADP
ajst-31202	25	2	example	example	NOUN
ajst-31202	25	3	,	,	PUNCT
ajst-31202	25	4	in	in	ADP
ajst-31202	25	5	tumor	tumor	NOUN
ajst-31202	25	6	microenvironment	microenvironment	ADJ
ajst-31202	25	7	studies	study	NOUN
ajst-31202	25	8	,	,	PUNCT
ajst-31202	25	9	scrnaseq	scrnaseq	PROPN
ajst-31202	25	10	can	can	AUX
ajst-31202	25	11	identify	identify	VERB
ajst-31202	25	12	cellular	cellular	ADJ
ajst-31202	25	13	subtypes	subtype	NOUN
ajst-31202	25	14	including	include	VERB
ajst-31202	25	15	tumor	tumor	NOUN
ajst-31202	25	16	cells	cell	NOUN
ajst-31202	25	17	and	and	CCONJ
ajst-31202	25	18	immune	immune	ADJ
ajst-31202	25	19	cells	cell	NOUN
ajst-31202	25	20	such	such	ADJ
ajst-31202	25	21	as	as	ADP
ajst-31202	25	22	t	t	PROPN
ajst-31202	25	23	cells	cell	NOUN
ajst-31202	25	24	and	and	CCONJ
ajst-31202	25	25	macrophages	macrophage	NOUN
ajst-31202	25	26	and	and	CCONJ
ajst-31202	25	27	characterize	characterize	VERB
ajst-31202	25	28	the	the	DET
ajst-31202	25	29	expression	expression	NOUN
ajst-31202	25	30	of	of	ADP
ajst-31202	25	31	immune	immune	ADJ
ajst-31202	25	32	checkpoint	checkpoint	NOUN
ajst-31202	25	33	genes	gene	NOUN
ajst-31202	25	34	(	(	PUNCT
ajst-31202	25	35	e.g.	e.g.	ADV
ajst-31202	25	36	,	,	PUNCT
ajst-31202	25	37	pd-1	pd-1	ADV
ajst-31202	25	38	,	,	PUNCT
ajst-31202	25	39	ctla-4	ctla-4	NOUN
ajst-31202	25	40	)	)	PUNCT
ajst-31202	26	1	[	[	X
ajst-31202	26	2	5	5	NUM
ajst-31202	26	3	]	]	PUNCT
ajst-31202	26	4	.	.	PUNCT
ajst-31202	27	1	st	st	PROPN
ajst-31202	27	2	can	can	AUX
ajst-31202	27	3	then	then	ADV
ajst-31202	27	4	determine	determine	VERB
ajst-31202	27	5	the	the	DET
ajst-31202	27	6	spatial	spatial	ADJ
ajst-31202	27	7	distribution	distribution	NOUN
ajst-31202	27	8	of	of	ADP
ajst-31202	27	9	these	these	DET
ajst-31202	27	10	cells	cell	NOUN
ajst-31202	27	11	,	,	PUNCT
ajst-31202	27	12	such	such	ADJ
ajst-31202	27	13	as	as	ADP
ajst-31202	27	14	whether	whether	SCONJ
ajst-31202	27	15	immune	immune	ADJ
ajst-31202	27	16	cells	cell	NOUN
ajst-31202	27	17	cluster	cluster	NOUN
ajst-31202	27	18	at	at	ADP
ajst-31202	27	19	tumor	tumor	NOUN
ajst-31202	27	20	margins	margin	NOUN
ajst-31202	27	21	or	or	CCONJ
ajst-31202	27	22	infiltrate	infiltrate	VERB
ajst-31202	27	23	the	the	DET
ajst-31202	27	24	tumor	tumor	NOUN
ajst-31202	27	25	core	core	NOUN
ajst-31202	27	26	,	,	PUNCT
ajst-31202	27	27	thereby	thereby	ADV
ajst-31202	27	28	revealing	reveal	VERB
ajst-31202	27	29	immune	immune	ADJ
ajst-31202	27	30	infiltration	infiltration	NOUN
ajst-31202	27	31	patterns	pattern	NOUN
ajst-31202	27	32	.	.	PUNCT
ajst-31202	28	1	the	the	DET
ajst-31202	28	2	integration	integration	NOUN
ajst-31202	28	3	of	of	ADP
ajst-31202	28	4	both	both	DET
ajst-31202	28	5	modalities	modality	NOUN
ajst-31202	28	6	enables	enable	VERB
ajst-31202	28	7	the	the	DET
ajst-31202	28	8	construction	construction	NOUN
ajst-31202	28	9	of	of	ADP
ajst-31202	28	10	detailed	detailed	ADJ
ajst-31202	28	11	tumor	tumor	NOUN
ajst-31202	28	12	microenvironment	microenvironment	NOUN
ajst-31202	28	13	maps	map	NOUN
ajst-31202	28	14	and	and	CCONJ
ajst-31202	28	15	uncovers	uncover	NOUN
ajst-31202	28	16	signaling	signal	VERB
ajst-31202	28	17	networks	network	NOUN
ajst-31202	28	18	between	between	ADP
ajst-31202	28	19	cells	cell	NOUN
ajst-31202	28	20	,	,	PUNCT
ajst-31202	28	21	as	as	ADV
ajst-31202	28	22	well	well	ADV
ajst-31202	28	23	as	as	ADP
ajst-31202	28	24	their	their	PRON
ajst-31202	28	25	associations	association	NOUN
ajst-31202	28	26	with	with	ADP
ajst-31202	28	27	therapeutic	therapeutic	ADJ
ajst-31202	28	28	responses	response	NOUN
ajst-31202	28	29	.	.	PUNCT
ajst-31202	29	1	for	for	ADP
ajst-31202	29	2	instance	instance	NOUN
ajst-31202	29	3	,	,	PUNCT
ajst-31202	29	4	keren	keren	PROPN
ajst-31202	29	5	et	et	PROPN
ajst-31202	29	6	al	al	PROPN
ajst-31202	29	7	.	.	PUNCT
ajst-31202	30	1	[	[	X
ajst-31202	30	2	6	6	NUM
ajst-31202	30	3	]	]	SYM
ajst-31202	30	4	(	(	PUNCT
ajst-31202	30	5	2018	2018	NUM
ajst-31202	30	6	)	)	PUNCT
ajst-31202	30	7	found	find	VERB
ajst-31202	30	8	that	that	SCONJ
ajst-31202	30	9	t	t	PROPN
ajst-31202	30	10	cells	cell	NOUN
ajst-31202	30	11	near	near	ADP
ajst-31202	30	12	the	the	DET
ajst-31202	30	13	tumor	tumor	NOUN
ajst-31202	30	14	core	core	NOUN
ajst-31202	30	15	in	in	ADP
ajst-31202	30	16	breast	breast	NOUN
ajst-31202	30	17	cancer	cancer	NOUN
ajst-31202	30	18	exhibited	exhibit	VERB
ajst-31202	30	19	a	a	DET
ajst-31202	30	20	more	more	ADV
ajst-31202	30	21	pronounced	pronounced	ADJ
ajst-31202	30	22	exhausted	exhausted	ADJ
ajst-31202	30	23	phenotype	phenotype	NOUN
ajst-31202	30	24	,	,	PUNCT
ajst-31202	30	25	suggesting	suggest	VERB
ajst-31202	30	26	that	that	SCONJ
ajst-31202	30	27	spatial	spatial	ADJ
ajst-31202	30	28	location	location	NOUN
ajst-31202	30	29	significantly	significantly	ADV
ajst-31202	30	30	influences	influence	VERB
ajst-31202	30	31	immune	immune	ADJ
ajst-31202	30	32	function	function	NOUN
ajst-31202	30	33	.	.	PUNCT
ajst-31202	31	1	similarly	similarly	ADV
ajst-31202	31	2	,	,	PUNCT
ajst-31202	31	3	moncada	moncada	PROPN
ajst-31202	31	4	et	et	PROPN
ajst-31202	31	5	al	al	PROPN
ajst-31202	31	6	.	.	PUNCT
ajst-31202	32	1	[	[	X
ajst-31202	32	2	7	7	NUM
ajst-31202	32	3	]	]	SYM
ajst-31202	32	4	(	(	PUNCT
ajst-31202	32	5	2020	2020	NUM
ajst-31202	32	6	)	)	PUNCT
ajst-31202	32	7	observed	observe	VERB
ajst-31202	32	8	that	that	SCONJ
ajst-31202	32	9	the	the	DET
ajst-31202	32	10	spatial	spatial	ADJ
ajst-31202	32	11	proximity	proximity	NOUN
ajst-31202	32	12	between	between	ADP
ajst-31202	32	13	fibroblasts	fibroblast	NOUN
ajst-31202	32	14	and	and	CCONJ
ajst-31202	32	15	tumor	tumor	NOUN
ajst-31202	32	16	cells	cell	NOUN
ajst-31202	32	17	in	in	ADP
ajst-31202	32	18	pancreatic	pancreatic	ADJ
ajst-31202	32	19	cancer	cancer	NOUN
ajst-31202	32	20	may	may	AUX
ajst-31202	32	21	promote	promote	VERB
ajst-31202	32	22	the	the	DET
ajst-31202	32	23	formation	formation	NOUN
ajst-31202	32	24	of	of	ADP
ajst-31202	32	25	the	the	DET
ajst-31202	32	26	tumor	tumor	NOUN
ajst-31202	32	27	microenvironment	microenvironment	NOUN
ajst-31202	32	28	.	.	PUNCT
ajst-31202	33	1	in	in	ADP
ajst-31202	33	2	neuroscience	neuroscience	NOUN
ajst-31202	33	3	,	,	PUNCT
ajst-31202	33	4	the	the	DET
ajst-31202	33	5	joint	joint	ADJ
ajst-31202	33	6	application	application	NOUN
ajst-31202	33	7	of	of	ADP
ajst-31202	33	8	scrna	scrna	NOUN
ajst-31202	33	9	-	-	PUNCT
ajst-31202	33	10	seq	seq	NOUN
ajst-31202	33	11	and	and	CCONJ
ajst-31202	33	12	st	st	PROPN
ajst-31202	33	13	has	have	AUX
ajst-31202	33	14	been	be	AUX
ajst-31202	33	15	instrumental	instrumental	ADJ
ajst-31202	33	16	in	in	ADP
ajst-31202	33	17	mapping	map	VERB
ajst-31202	33	18	neuronal	neuronal	ADJ
ajst-31202	33	19	spatial	spatial	ADJ
ajst-31202	33	20	organization	organization	NOUN
ajst-31202	33	21	and	and	CCONJ
ajst-31202	33	22	functional	functional	ADJ
ajst-31202	33	23	partitioning	partitioning	NOUN
ajst-31202	33	24	in	in	ADP
ajst-31202	33	25	the	the	DET
ajst-31202	33	26	cerebral	cerebral	ADJ
ajst-31202	33	27	cortex	cortex	NOUN
ajst-31202	33	28	.	.	PUNCT
ajst-31202	34	1	for	for	ADP
ajst-31202	34	2	example	example	NOUN
ajst-31202	34	3	,	,	PUNCT
ajst-31202	34	4	st	st	PROPN
ajst-31202	34	5	can	can	AUX
ajst-31202	34	6	first	first	ADV
ajst-31202	34	7	delineate	delineate	VERB
ajst-31202	34	8	regional	regional	ADJ
ajst-31202	34	9	expression	expression	NOUN
ajst-31202	34	10	landscapes	landscape	NOUN
ajst-31202	34	11	,	,	PUNCT
ajst-31202	34	12	and	and	CCONJ
ajst-31202	34	13	scrna	scrna	NOUN
ajst-31202	34	14	-	-	PUNCT
ajst-31202	34	15	seq	seq	NOUN
ajst-31202	34	16	can	can	AUX
ajst-31202	34	17	then	then	ADV
ajst-31202	34	18	annotate	annotate	VERB
ajst-31202	34	19	neuronal	neuronal	ADJ
ajst-31202	34	20	subtypes	subtype	NOUN
ajst-31202	34	21	,	,	PUNCT
ajst-31202	34	22	allowing	allow	VERB
ajst-31202	34	23	for	for	ADP
ajst-31202	34	24	precise	precise	ADJ
ajst-31202	34	25	correlation	correlation	NOUN
ajst-31202	34	26	between	between	ADP
ajst-31202	34	27	functional	functional	ADJ
ajst-31202	34	28	anatomy	anatomy	NOUN
ajst-31202	34	29	and	and	CCONJ
ajst-31202	34	30	molecular	molecular	ADJ
ajst-31202	34	31	identity	identity	NOUN
ajst-31202	34	32	[	[	X
ajst-31202	34	33	8	8	NUM
ajst-31202	34	34	]	]	PUNCT
ajst-31202	34	35	.	.	PUNCT
ajst-31202	35	1	these	these	DET
ajst-31202	35	2	studies	study	NOUN
ajst-31202	35	3	demonstrate	demonstrate	VERB
ajst-31202	35	4	that	that	SCONJ
ajst-31202	35	5	integrating	integrate	VERB
ajst-31202	35	6	scrna	scrna	NOUN
ajst-31202	35	7	-	-	PUNCT
ajst-31202	35	8	seq	seq	NOUN
ajst-31202	35	9	and	and	CCONJ
ajst-31202	35	10	st	st	PROPN
ajst-31202	35	11	not	not	PART
ajst-31202	35	12	only	only	ADV
ajst-31202	35	13	provides	provide	VERB
ajst-31202	35	14	complementary	complementary	ADJ
ajst-31202	35	15	spatial	spatial	ADJ
ajst-31202	35	16	resolution	resolution	NOUN
ajst-31202	35	17	but	but	CCONJ
ajst-31202	35	18	also	also	ADV
ajst-31202	35	19	offers	offer	VERB
ajst-31202	35	20	a	a	DET
ajst-31202	35	21	more	more	ADV
ajst-31202	35	22	comprehensive	comprehensive	ADJ
ajst-31202	35	23	perspective	perspective	NOUN
ajst-31202	35	24	on	on	ADP
ajst-31202	35	25	tissue	tissue	NOUN
ajst-31202	35	26	function	function	NOUN
ajst-31202	35	27	,	,	PUNCT
ajst-31202	35	28	cellular	cellular	ADJ
ajst-31202	35	29	interactions	interaction	NOUN
ajst-31202	35	30	,	,	PUNCT
ajst-31202	35	31	and	and	CCONJ
ajst-31202	35	32	disease	disease	NOUN
ajst-31202	35	33	mechanisms	mechanism	NOUN
ajst-31202	35	34	.	.	PUNCT
ajst-31202	36	1	looking	look	VERB
ajst-31202	36	2	ahead	ahead	ADV
ajst-31202	36	3	,	,	PUNCT
ajst-31202	36	4	continued	continue	VERB
ajst-31202	36	5	advances	advance	NOUN
ajst-31202	36	6	in	in	ADP
ajst-31202	36	7	multimodal	multimodal	ADJ
ajst-31202	36	8	integration	integration	NOUN
ajst-31202	36	9	particularly	particularly	ADV
ajst-31202	36	10	the	the	DET
ajst-31202	36	11	combination	combination	NOUN
ajst-31202	36	12	of	of	ADP
ajst-31202	36	13	scrna	scrna	NOUN
ajst-31202	36	14	-	-	PUNCT
ajst-31202	36	15	seq	seq	PROPN
ajst-31202	36	16	,	,	PUNCT
ajst-31202	36	17	st	st	PROPN
ajst-31202	36	18	,	,	PUNCT
ajst-31202	36	19	proteomics	proteomic	NOUN
ajst-31202	36	20	,	,	PUNCT
ajst-31202	36	21	and	and	CCONJ
ajst-31202	36	22	epigenomics	epigenomic	NOUN
ajst-31202	36	23	,	,	PUNCT
ajst-31202	36	24	coupled	couple	VERB
ajst-31202	36	25	with	with	ADP
ajst-31202	36	26	ai	ai	ADJ
ajst-31202	36	27	-	-	PUNCT
ajst-31202	36	28	driven	drive	VERB
ajst-31202	36	29	highdimensional	highdimensional	ADJ
ajst-31202	36	30	data	datum	NOUN
ajst-31202	36	31	analytics	analytic	NOUN
ajst-31202	36	32	are	be	AUX
ajst-31202	36	33	expected	expect	VERB
ajst-31202	36	34	to	to	PART
ajst-31202	36	35	enable	enable	VERB
ajst-31202	36	36	a	a	DET
ajst-31202	36	37	more	more	ADV
ajst-31202	36	38	systematic	systematic	ADJ
ajst-31202	36	39	understanding	understanding	NOUN
ajst-31202	36	40	of	of	ADP
ajst-31202	36	41	spatial	spatial	ADJ
ajst-31202	36	42	-	-	PUNCT
ajst-31202	36	43	molecular	molecular	ADJ
ajst-31202	36	44	mechanisms	mechanism	NOUN
ajst-31202	36	45	in	in	ADP
ajst-31202	36	46	51	51	NUM
ajst-31202	36	47	biological	biological	ADJ
ajst-31202	36	48	systems	system	NOUN
ajst-31202	36	49	.	.	PUNCT
ajst-31202	37	1	this	this	DET
ajst-31202	37	2	progress	progress	NOUN
ajst-31202	37	3	holds	hold	VERB
ajst-31202	37	4	great	great	ADJ
ajst-31202	37	5	promise	promise	NOUN
ajst-31202	37	6	for	for	ADP
ajst-31202	37	7	supporting	support	VERB
ajst-31202	37	8	precision	precision	NOUN
ajst-31202	37	9	medicine	medicine	NOUN
ajst-31202	37	10	and	and	CCONJ
ajst-31202	37	11	elucidating	elucidate	VERB
ajst-31202	37	12	the	the	DET
ajst-31202	37	13	molecular	molecular	ADJ
ajst-31202	37	14	basis	basis	NOUN
ajst-31202	37	15	of	of	ADP
ajst-31202	37	16	disease	disease	NOUN
ajst-31202	37	17	.	.	PUNCT
ajst-31202	38	1	2	2	X
ajst-31202	38	2	.	.	X
ajst-31202	38	3	scrna	scrna	NOUN
ajst-31202	38	4	-	-	PUNCT
ajst-31202	38	5	seq	seq	NOUN
ajst-31202	38	6	(	(	PUNCT
ajst-31202	38	7	single	single	ADJ
ajst-31202	38	8	-	-	PUNCT
ajst-31202	38	9	cell	cell	NOUN
ajst-31202	38	10	rna	rna	NOUN
ajst-31202	38	11	sequencing	sequencing	NOUN
ajst-31202	38	12	)	)	PUNCT
ajst-31202	38	13	2.1	2.1	NUM
ajst-31202	38	14	.	.	PUNCT
ajst-31202	39	1	classification	classification	NOUN
ajst-31202	39	2	of	of	ADP
ajst-31202	39	3	scrna	scrna	NOUN
ajst-31202	39	4	-	-	PUNCT
ajst-31202	39	5	seq	seq	NOUN
ajst-31202	39	6	technologies	technology	NOUN
ajst-31202	39	7	since	since	SCONJ
ajst-31202	39	8	its	its	PRON
ajst-31202	39	9	first	first	ADJ
ajst-31202	39	10	application	application	NOUN
ajst-31202	39	11	in	in	ADP
ajst-31202	39	12	2009	2009	NUM
ajst-31202	39	13	for	for	ADP
ajst-31202	39	14	whole	whole	ADJ
ajst-31202	39	15	-	-	PUNCT
ajst-31202	39	16	transcriptome	transcriptome	NOUN
ajst-31202	39	17	mrna	mrna	NOUN
ajst-31202	39	18	profiling	profiling	NOUN
ajst-31202	39	19	of	of	ADP
ajst-31202	39	20	individual	individual	ADJ
ajst-31202	39	21	cells	cell	NOUN
ajst-31202	39	22	,	,	PUNCT
ajst-31202	39	23	single	single	ADJ
ajst-31202	39	24	-	-	PUNCT
ajst-31202	39	25	cell	cell	NOUN
ajst-31202	39	26	rna	rna	NOUN
ajst-31202	39	27	sequencing	sequence	VERB
ajst-31202	39	28	(	(	PUNCT
ajst-31202	39	29	scrna	scrna	NOUN
ajst-31202	39	30	-	-	PUNCT
ajst-31202	39	31	seq	seq	NOUN
ajst-31202	39	32	)	)	PUNCT
ajst-31202	39	33	has	have	AUX
ajst-31202	39	34	evolved	evolve	VERB
ajst-31202	39	35	into	into	ADP
ajst-31202	39	36	a	a	DET
ajst-31202	39	37	diverse	diverse	ADJ
ajst-31202	39	38	array	array	NOUN
ajst-31202	39	39	of	of	ADP
ajst-31202	39	40	sub	sub	NOUN
ajst-31202	39	41	-	-	NOUN
ajst-31202	39	42	technologies	technology	NOUN
ajst-31202	39	43	.	.	PUNCT
ajst-31202	40	1	these	these	PRON
ajst-31202	40	2	can	can	AUX
ajst-31202	40	3	be	be	AUX
ajst-31202	40	4	broadly	broadly	ADV
ajst-31202	40	5	categorized	categorize	VERB
ajst-31202	40	6	into	into	ADP
ajst-31202	40	7	two	two	NUM
ajst-31202	40	8	classes	class	NOUN
ajst-31202	40	9	based	base	VERB
ajst-31202	40	10	on	on	ADP
ajst-31202	40	11	the	the	DET
ajst-31202	40	12	transcript	transcript	NOUN
ajst-31202	40	13	coverage	coverage	NOUN
ajst-31202	40	14	they	they	PRON
ajst-31202	40	15	achieve	achieve	VERB
ajst-31202	40	16	.	.	PUNCT
ajst-31202	41	1	the	the	DET
ajst-31202	41	2	first	first	ADJ
ajst-31202	41	3	category	category	NOUN
ajst-31202	41	4	includes	include	VERB
ajst-31202	41	5	full	full	ADJ
ajst-31202	41	6	-	-	PUNCT
ajst-31202	41	7	length	length	NOUN
ajst-31202	41	8	transcript	transcript	NOUN
ajst-31202	41	9	sequencing	sequence	VERB
ajst-31202	41	10	technologies	technology	NOUN
ajst-31202	41	11	,	,	PUNCT
ajst-31202	41	12	such	such	ADJ
ajst-31202	41	13	as	as	ADP
ajst-31202	41	14	smart	smart	ADJ
ajst-31202	41	15	-	-	PUNCT
ajst-31202	41	16	seq2	seq2	ADJ
ajst-31202	41	17	,	,	PUNCT
ajst-31202	41	18	matq	matq	NOUN
ajst-31202	41	19	-	-	PUNCT
ajst-31202	41	20	seq	seq	NOUN
ajst-31202	41	21	(	(	PUNCT
ajst-31202	41	22	multiple	multiple	ADJ
ajst-31202	41	23	annealing	anneal	VERB
ajst-31202	41	24	and	and	CCONJ
ajst-31202	41	25	tailing	tail	VERB
ajst-31202	41	26	-	-	PUNCT
ajst-31202	41	27	based	base	VERB
ajst-31202	41	28	quantitative	quantitative	ADJ
ajst-31202	41	29	sequencing	sequencing	NOUN
ajst-31202	41	30	)	)	PUNCT
ajst-31202	41	31	,	,	PUNCT
ajst-31202	41	32	and	and	CCONJ
ajst-31202	41	33	super	super	ADJ
ajst-31202	41	34	-	-	ADJ
ajst-31202	41	35	seq	seq	ADJ
ajst-31202	41	36	(	(	PUNCT
ajst-31202	41	37	single	single	ADJ
ajst-31202	41	38	-	-	PUNCT
ajst-31202	41	39	cell	cell	NOUN
ajst-31202	41	40	universal	universal	ADJ
ajst-31202	41	41	poly(a)-independent	poly(a)-independent	NOUN
ajst-31202	41	42	rna	rna	NOUN
ajst-31202	41	43	sequencing	sequencing	NOUN
ajst-31202	41	44	)	)	PUNCT
ajst-31202	41	45	.	.	PUNCT
ajst-31202	42	1	these	these	DET
ajst-31202	42	2	methods	method	NOUN
ajst-31202	42	3	offer	offer	VERB
ajst-31202	42	4	high	high	ADJ
ajst-31202	42	5	sensitivity	sensitivity	NOUN
ajst-31202	42	6	and	and	CCONJ
ajst-31202	42	7	accuracy	accuracy	NOUN
ajst-31202	42	8	,	,	PUNCT
ajst-31202	42	9	enabling	enable	VERB
ajst-31202	42	10	comprehensive	comprehensive	ADJ
ajst-31202	42	11	analysis	analysis	NOUN
ajst-31202	42	12	of	of	ADP
ajst-31202	42	13	transcript	transcript	NOUN
ajst-31202	42	14	isoforms	isoform	NOUN
ajst-31202	42	15	,	,	PUNCT
ajst-31202	42	16	including	include	VERB
ajst-31202	42	17	alternative	alternative	ADJ
ajst-31202	42	18	splicing	splicing	NOUN
ajst-31202	42	19	and	and	CCONJ
ajst-31202	42	20	allele	allele	NOUN
ajst-31202	42	21	-	-	PUNCT
ajst-31202	42	22	specific	specific	ADJ
ajst-31202	42	23	expression	expression	NOUN
ajst-31202	42	24	.	.	PUNCT
ajst-31202	43	1	they	they	PRON
ajst-31202	43	2	are	be	AUX
ajst-31202	43	3	thus	thus	ADV
ajst-31202	43	4	well	well	ADV
ajst-31202	43	5	-	-	PUNCT
ajst-31202	43	6	suited	suit	VERB
ajst-31202	43	7	for	for	ADP
ajst-31202	43	8	studies	study	NOUN
ajst-31202	43	9	requiring	require	VERB
ajst-31202	43	10	detailed	detailed	ADJ
ajst-31202	43	11	transcript	transcript	NOUN
ajst-31202	43	12	-	-	PUNCT
ajst-31202	43	13	level	level	NOUN
ajst-31202	43	14	resolution	resolution	NOUN
ajst-31202	43	15	.	.	PUNCT
ajst-31202	44	1	however	however	ADV
ajst-31202	44	2	,	,	PUNCT
ajst-31202	44	3	they	they	PRON
ajst-31202	44	4	typically	typically	ADV
ajst-31202	44	5	suffer	suffer	VERB
ajst-31202	44	6	from	from	ADP
ajst-31202	44	7	low	low	ADJ
ajst-31202	44	8	cellular	cellular	ADJ
ajst-31202	44	9	throughput	throughput	NOUN
ajst-31202	44	10	and	and	CCONJ
ajst-31202	44	11	relatively	relatively	ADV
ajst-31202	44	12	high	high	ADJ
ajst-31202	44	13	costs	cost	NOUN
ajst-31202	44	14	[	[	X
ajst-31202	44	15	9	9	NUM
ajst-31202	44	16	]	]	PUNCT
ajst-31202	44	17	.	.	PUNCT
ajst-31202	45	1	the	the	DET
ajst-31202	45	2	second	second	ADJ
ajst-31202	45	3	category	category	NOUN
ajst-31202	45	4	comprises	comprise	VERB
ajst-31202	45	5	3	3	NUM
ajst-31202	45	6	or	or	CCONJ
ajst-31202	45	7	5	5	NUM
ajst-31202	45	8	-end	-end	NOUN
ajst-31202	45	9	counting	count	VERB
ajst-31202	45	10	methods	method	NOUN
ajst-31202	45	11	,	,	PUNCT
ajst-31202	45	12	such	such	ADJ
ajst-31202	45	13	as	as	ADP
ajst-31202	45	14	drop	drop	NOUN
ajst-31202	45	15	-	-	PUNCT
ajst-31202	45	16	seq	seq	NOUN
ajst-31202	45	17	,	,	PUNCT
ajst-31202	45	18	seq	seq	NOUN
ajst-31202	45	19	-	-	PUNCT
ajst-31202	45	20	well	well	ADJ
ajst-31202	45	21	,	,	PUNCT
ajst-31202	45	22	chromium	chromium	NOUN
ajst-31202	45	23	(	(	PUNCT
ajst-31202	45	24	10x	10x	NUM
ajst-31202	45	25	genomics	genomic	NOUN
ajst-31202	45	26	)	)	PUNCT
ajst-31202	45	27	,	,	PUNCT
ajst-31202	45	28	and	and	CCONJ
ajst-31202	45	29	strt	strt	NOUN
ajst-31202	45	30	-	-	PUNCT
ajst-31202	45	31	seq	seq	NOUN
ajst-31202	45	32	(	(	PUNCT
ajst-31202	45	33	single	single	ADJ
ajst-31202	45	34	-	-	PUNCT
ajst-31202	45	35	cell	cell	NOUN
ajst-31202	45	36	tagged	tag	VERB
ajst-31202	45	37	reverse	reverse	NOUN
ajst-31202	45	38	transcription	transcription	NOUN
ajst-31202	45	39	sequencing	sequence	VERB
ajst-31202	45	40	)	)	PUNCT
ajst-31202	45	41	.	.	PUNCT
ajst-31202	46	1	these	these	DET
ajst-31202	46	2	techniques	technique	NOUN
ajst-31202	46	3	are	be	AUX
ajst-31202	46	4	designed	design	VERB
ajst-31202	46	5	for	for	ADP
ajst-31202	46	6	high	high	ADJ
ajst-31202	46	7	-	-	PUNCT
ajst-31202	46	8	throughput	throughput	NOUN
ajst-31202	46	9	,	,	PUNCT
ajst-31202	46	10	cost	cost	NOUN
ajst-31202	46	11	-	-	PUNCT
ajst-31202	46	12	effective	effective	ADJ
ajst-31202	46	13	profiling	profiling	NOUN
ajst-31202	46	14	by	by	ADP
ajst-31202	46	15	capturing	capture	VERB
ajst-31202	46	16	transcript	transcript	NOUN
ajst-31202	46	17	termini	termini	NOUN
ajst-31202	46	18	and	and	CCONJ
ajst-31202	46	19	incorporating	incorporate	VERB
ajst-31202	46	20	unique	unique	ADJ
ajst-31202	46	21	molecular	molecular	ADJ
ajst-31202	46	22	identifiers	identifier	NOUN
ajst-31202	46	23	(	(	PUNCT
ajst-31202	46	24	umis	umis	INTJ
ajst-31202	46	25	)	)	PUNCT
ajst-31202	46	26	to	to	PART
ajst-31202	46	27	quantify	quantify	VERB
ajst-31202	46	28	gene	gene	NOUN
ajst-31202	46	29	expression	expression	NOUN
ajst-31202	46	30	levels	level	NOUN
ajst-31202	46	31	.	.	PUNCT
ajst-31202	47	1	while	while	SCONJ
ajst-31202	47	2	advantageous	advantageous	ADJ
ajst-31202	47	3	for	for	ADP
ajst-31202	47	4	large	large	ADJ
ajst-31202	47	5	-	-	PUNCT
ajst-31202	47	6	scale	scale	NOUN
ajst-31202	47	7	studies	study	NOUN
ajst-31202	47	8	due	due	ADP
ajst-31202	47	9	to	to	ADP
ajst-31202	47	10	their	their	PRON
ajst-31202	47	11	scalability	scalability	NOUN
ajst-31202	47	12	and	and	CCONJ
ajst-31202	47	13	affordability	affordability	NOUN
ajst-31202	47	14	,	,	PUNCT
ajst-31202	47	15	these	these	DET
ajst-31202	47	16	approaches	approach	NOUN
ajst-31202	47	17	are	be	AUX
ajst-31202	47	18	limited	limit	VERB
ajst-31202	47	19	in	in	ADP
ajst-31202	47	20	their	their	PRON
ajst-31202	47	21	ability	ability	NOUN
ajst-31202	47	22	to	to	PART
ajst-31202	47	23	resolve	resolve	VERB
ajst-31202	47	24	transcript	transcript	NOUN
ajst-31202	47	25	isoforms	isoform	NOUN
ajst-31202	47	26	and	and	CCONJ
ajst-31202	47	27	generally	generally	ADV
ajst-31202	47	28	exhibit	exhibit	VERB
ajst-31202	47	29	reduced	reduce	VERB
ajst-31202	47	30	sensitivity	sensitivity	NOUN
ajst-31202	47	31	to	to	ADP
ajst-31202	47	32	low	low	ADJ
ajst-31202	47	33	-	-	PUNCT
ajst-31202	47	34	abundance	abundance	NOUN
ajst-31202	47	35	transcripts	transcript	NOUN
ajst-31202	47	36	[	[	X
ajst-31202	47	37	10	10	NUM
ajst-31202	47	38	]	]	PUNCT
ajst-31202	47	39	.	.	PUNCT
ajst-31202	48	1	2.2	2.2	NUM
ajst-31202	48	2	.	.	PUNCT
ajst-31202	48	3	workflow	workflow	NOUN
ajst-31202	48	4	of	of	ADP
ajst-31202	48	5	scrna	scrna	NOUN
ajst-31202	48	6	-	-	PUNCT
ajst-31202	48	7	seq	seq	NOUN
ajst-31202	48	8	in	in	ADP
ajst-31202	48	9	practical	practical	ADJ
ajst-31202	48	10	applications	application	NOUN
ajst-31202	48	11	,	,	PUNCT
ajst-31202	48	12	scrna	scrna	NOUN
ajst-31202	48	13	-	-	PUNCT
ajst-31202	48	14	seq	seq	NOUN
ajst-31202	48	15	workflows	workflow	NOUN
ajst-31202	48	16	require	require	VERB
ajst-31202	48	17	integration	integration	NOUN
ajst-31202	48	18	with	with	ADP
ajst-31202	48	19	various	various	ADJ
ajst-31202	48	20	cell	cell	NOUN
ajst-31202	48	21	isolation	isolation	NOUN
ajst-31202	48	22	strategies	strategy	NOUN
ajst-31202	48	23	.	.	PUNCT
ajst-31202	49	1	these	these	PRON
ajst-31202	49	2	include	include	VERB
ajst-31202	49	3	manual	manual	ADJ
ajst-31202	49	4	micromanipulation	micromanipulation	NOUN
ajst-31202	49	5	(	(	PUNCT
ajst-31202	49	6	e.g.	e.g.	ADV
ajst-31202	49	7	,	,	PUNCT
ajst-31202	49	8	mouth	mouth	NOUN
ajst-31202	49	9	pipetting	pipetting	NOUN
ajst-31202	49	10	)	)	PUNCT
ajst-31202	49	11	,	,	PUNCT
ajst-31202	49	12	laser	laser	NOUN
ajst-31202	49	13	capture	capture	NOUN
ajst-31202	49	14	microdissection	microdissection	NOUN
ajst-31202	49	15	(	(	PUNCT
ajst-31202	49	16	lcm	lcm	NOUN
ajst-31202	49	17	)	)	PUNCT
ajst-31202	49	18	,	,	PUNCT
ajst-31202	49	19	and	and	CCONJ
ajst-31202	49	20	fluorescence	fluorescence	ADJ
ajst-31202	49	21	-	-	PUNCT
ajst-31202	49	22	activated	activate	VERB
ajst-31202	49	23	cell	cell	NOUN
ajst-31202	49	24	sorting	sorting	NOUN
ajst-31202	49	25	(	(	PUNCT
ajst-31202	49	26	facs	fac	NOUN
ajst-31202	49	27	)	)	PUNCT
ajst-31202	49	28	,	,	PUNCT
ajst-31202	49	29	as	as	ADV
ajst-31202	49	30	well	well	ADV
ajst-31202	49	31	as	as	ADP
ajst-31202	49	32	more	more	ADV
ajst-31202	49	33	advanced	advanced	ADJ
ajst-31202	49	34	droplet	droplet	ADV
ajst-31202	49	35	-	-	PUNCT
ajst-31202	49	36	based	base	VERB
ajst-31202	49	37	and	and	CCONJ
ajst-31202	49	38	microfluidic	microfluidic	ADJ
ajst-31202	49	39	technologies	technology	NOUN
ajst-31202	49	40	[	[	X
ajst-31202	49	41	11	11	NUM
ajst-31202	49	42	]	]	PUNCT
ajst-31202	49	43	.	.	PUNCT
ajst-31202	50	1	droplet	droplet	ADJ
ajst-31202	50	2	-	-	PUNCT
ajst-31202	50	3	based	base	VERB
ajst-31202	50	4	platforms	platform	NOUN
ajst-31202	50	5	,	,	PUNCT
ajst-31202	50	6	such	such	ADJ
ajst-31202	50	7	as	as	ADP
ajst-31202	50	8	drop	drop	NOUN
ajst-31202	50	9	-	-	PUNCT
ajst-31202	50	10	seq	seq	NOUN
ajst-31202	50	11	,	,	PUNCT
ajst-31202	50	12	encapsulate	encapsulate	VERB
ajst-31202	50	13	single	single	ADJ
ajst-31202	50	14	cells	cell	NOUN
ajst-31202	50	15	with	with	ADP
ajst-31202	50	16	barcoded	barcode	VERB
ajst-31202	50	17	beads	bead	NOUN
ajst-31202	50	18	within	within	ADP
ajst-31202	50	19	nanoliter	nanoliter	ADJ
ajst-31202	50	20	-	-	PUNCT
ajst-31202	50	21	scale	scale	NOUN
ajst-31202	50	22	droplets	droplet	NOUN
ajst-31202	50	23	to	to	PART
ajst-31202	50	24	achieve	achieve	VERB
ajst-31202	50	25	parallelized	parallelized	ADJ
ajst-31202	50	26	separation	separation	NOUN
ajst-31202	50	27	and	and	CCONJ
ajst-31202	50	28	indexing	indexing	NOUN
ajst-31202	50	29	.	.	PUNCT
ajst-31202	51	1	in	in	ADP
ajst-31202	51	2	contrast	contrast	NOUN
ajst-31202	51	3	,	,	PUNCT
ajst-31202	51	4	microfluidic	microfluidic	ADJ
ajst-31202	51	5	platforms	platform	NOUN
ajst-31202	51	6	like	like	ADP
ajst-31202	51	7	fluidigm	fluidigm	PROPN
ajst-31202	51	8	c1	c1	PROPN
ajst-31202	51	9	utilize	utilize	VERB
ajst-31202	51	10	microchannels	microchannel	NOUN
ajst-31202	51	11	and	and	CCONJ
ajst-31202	51	12	valve	valve	VERB
ajst-31202	51	13	systems	system	NOUN
ajst-31202	51	14	for	for	ADP
ajst-31202	51	15	precise	precise	ADJ
ajst-31202	51	16	control	control	NOUN
ajst-31202	51	17	over	over	ADP
ajst-31202	51	18	single	single	ADJ
ajst-31202	51	19	-	-	PUNCT
ajst-31202	51	20	cell	cell	NOUN
ajst-31202	51	21	capture	capture	NOUN
ajst-31202	51	22	and	and	CCONJ
ajst-31202	51	23	processing	process	VERB
ajst-31202	51	24	[	[	X
ajst-31202	51	25	12	12	NUM
ajst-31202	51	26	]	]	PUNCT
ajst-31202	51	27	.	.	PUNCT
ajst-31202	52	1	these	these	DET
ajst-31202	52	2	two	two	NUM
ajst-31202	52	3	approaches	approach	NOUN
ajst-31202	52	4	differ	differ	VERB
ajst-31202	52	5	significantly	significantly	ADV
ajst-31202	52	6	in	in	ADP
ajst-31202	52	7	their	their	PRON
ajst-31202	52	8	underlying	underlie	VERB
ajst-31202	52	9	principles	principle	NOUN
ajst-31202	52	10	,	,	PUNCT
ajst-31202	52	11	instrumentation	instrumentation	NOUN
ajst-31202	52	12	,	,	PUNCT
ajst-31202	52	13	and	and	CCONJ
ajst-31202	52	14	throughput	throughput	NOUN
ajst-31202	52	15	characteristics	characteristic	NOUN
ajst-31202	52	16	.	.	PUNCT
ajst-31202	53	1	therefore	therefore	ADV
ajst-31202	53	2	,	,	PUNCT
ajst-31202	53	3	the	the	DET
ajst-31202	53	4	selection	selection	NOUN
ajst-31202	53	5	of	of	ADP
ajst-31202	53	6	an	an	DET
ajst-31202	53	7	appropriate	appropriate	ADJ
ajst-31202	53	8	method	method	NOUN
ajst-31202	53	9	should	should	AUX
ajst-31202	53	10	be	be	AUX
ajst-31202	53	11	carefully	carefully	ADV
ajst-31202	53	12	determined	determine	VERB
ajst-31202	53	13	based	base	VERB
ajst-31202	53	14	on	on	ADP
ajst-31202	53	15	experimental	experimental	ADJ
ajst-31202	53	16	goals	goal	NOUN
ajst-31202	53	17	,	,	PUNCT
ajst-31202	53	18	sample	sample	NOUN
ajst-31202	53	19	types	type	NOUN
ajst-31202	53	20	,	,	PUNCT
ajst-31202	53	21	and	and	CCONJ
ajst-31202	53	22	the	the	DET
ajst-31202	53	23	required	require	VERB
ajst-31202	53	24	scale	scale	NOUN
ajst-31202	53	25	of	of	ADP
ajst-31202	53	26	analysis	analysis	NOUN
ajst-31202	53	27	.	.	PUNCT
ajst-31202	54	1	figure	figure	NOUN
ajst-31202	54	2	1	1	NUM
ajst-31202	54	3	.	.	PUNCT
ajst-31202	54	4	single	single	ADJ
ajst-31202	54	5	-	-	PUNCT
ajst-31202	54	6	cell	cell	NOUN
ajst-31202	54	7	transcriptome	transcriptome	ADJ
ajst-31202	54	8	sequencing	sequence	VERB
ajst-31202	54	9	workflow	workflow	NOUN
ajst-31202	54	10	the	the	DET
ajst-31202	54	11	scrna	scrna	NOUN
ajst-31202	54	12	-	-	PUNCT
ajst-31202	54	13	seq	seq	NOUN
ajst-31202	54	14	workflow	workflow	NOUN
ajst-31202	54	15	is	be	AUX
ajst-31202	54	16	relatively	relatively	ADV
ajst-31202	54	17	straightforward	straightforward	ADJ
ajst-31202	54	18	and	and	CCONJ
ajst-31202	54	19	efficient	efficient	ADJ
ajst-31202	54	20	:	:	PUNCT
ajst-31202	54	21	first	first	ADJ
ajst-31202	54	22	,	,	PUNCT
ajst-31202	54	23	tissue	tissue	NOUN
ajst-31202	54	24	is	be	AUX
ajst-31202	54	25	dissociated	dissociate	VERB
ajst-31202	54	26	to	to	PART
ajst-31202	54	27	isolate	isolate	VERB
ajst-31202	54	28	single	single	ADJ
ajst-31202	54	29	cells	cell	NOUN
ajst-31202	54	30	and	and	CCONJ
ajst-31202	54	31	prepare	prepare	VERB
ajst-31202	54	32	a	a	DET
ajst-31202	54	33	cell	cell	NOUN
ajst-31202	54	34	suspension	suspension	NOUN
ajst-31202	54	35	,	,	PUNCT
ajst-31202	54	36	ensuring	ensure	VERB
ajst-31202	54	37	cell	cell	NOUN
ajst-31202	54	38	integrity	integrity	NOUN
ajst-31202	54	39	and	and	CCONJ
ajst-31202	54	40	viability	viability	NOUN
ajst-31202	54	41	while	while	SCONJ
ajst-31202	54	42	minimizing	minimize	VERB
ajst-31202	54	43	cell	cell	NOUN
ajst-31202	54	44	death	death	NOUN
ajst-31202	54	45	and	and	CCONJ
ajst-31202	54	46	aggregation	aggregation	NOUN
ajst-31202	54	47	.	.	PUNCT
ajst-31202	55	1	next	next	ADJ
ajst-31202	55	2	,	,	PUNCT
ajst-31202	55	3	single	single	ADJ
ajst-31202	55	4	cells	cell	NOUN
ajst-31202	55	5	are	be	AUX
ajst-31202	55	6	combined	combine	VERB
ajst-31202	55	7	with	with	ADP
ajst-31202	55	8	barcoded	barcode	VERB
ajst-31202	55	9	beads	bead	NOUN
ajst-31202	55	10	or	or	CCONJ
ajst-31202	55	11	microfluidic	microfluidic	ADJ
ajst-31202	55	12	chips	chip	NOUN
ajst-31202	55	13	,	,	PUNCT
ajst-31202	55	14	where	where	SCONJ
ajst-31202	55	15	they	they	PRON
ajst-31202	55	16	are	be	AUX
ajst-31202	55	17	lysed	lyse	VERB
ajst-31202	55	18	within	within	ADP
ajst-31202	55	19	a	a	DET
ajst-31202	55	20	confined	confine	VERB
ajst-31202	55	21	reaction	reaction	NOUN
ajst-31202	55	22	space	space	NOUN
ajst-31202	55	23	to	to	PART
ajst-31202	55	24	capture	capture	VERB
ajst-31202	55	25	mrna	mrna	PROPN
ajst-31202	55	26	,	,	PUNCT
ajst-31202	55	27	which	which	PRON
ajst-31202	55	28	is	be	AUX
ajst-31202	55	29	then	then	ADV
ajst-31202	55	30	reverse	reverse	ADJ
ajst-31202	55	31	transcribed	transcribe	VERB
ajst-31202	55	32	into	into	ADP
ajst-31202	55	33	complementary	complementary	ADJ
ajst-31202	55	34	dna	dna	PROPN
ajst-31202	55	35	(	(	PUNCT
ajst-31202	55	36	cdna	cdna	PROPN
ajst-31202	55	37	)	)	PUNCT
ajst-31202	55	38	.	.	PUNCT
ajst-31202	56	1	unique	unique	ADJ
ajst-31202	56	2	molecular	molecular	ADJ
ajst-31202	56	3	identifiers	identifier	NOUN
ajst-31202	56	4	(	(	PUNCT
ajst-31202	56	5	umis	umis	ADV
ajst-31202	56	6	)	)	PUNCT
ajst-31202	56	7	are	be	AUX
ajst-31202	56	8	incorporated	incorporate	VERB
ajst-31202	56	9	during	during	ADP
ajst-31202	56	10	this	this	DET
ajst-31202	56	11	process	process	NOUN
ajst-31202	56	12	to	to	PART
ajst-31202	56	13	distinguish	distinguish	VERB
ajst-31202	56	14	individual	individual	ADJ
ajst-31202	56	15	molecules	molecule	NOUN
ajst-31202	56	16	.	.	PUNCT
ajst-31202	57	1	the	the	DET
ajst-31202	57	2	cdna	cdna	PROPN
ajst-31202	57	3	is	be	AUX
ajst-31202	57	4	then	then	ADV
ajst-31202	57	5	amplified	amplify	VERB
ajst-31202	57	6	to	to	PART
ajst-31202	57	7	generate	generate	VERB
ajst-31202	57	8	a	a	DET
ajst-31202	57	9	sequencing	sequence	VERB
ajst-31202	57	10	library	library	NOUN
ajst-31202	57	11	,	,	PUNCT
ajst-31202	57	12	with	with	ADP
ajst-31202	57	13	a	a	DET
ajst-31202	57	14	focus	focus	NOUN
ajst-31202	57	15	on	on	ADP
ajst-31202	57	16	ensuring	ensure	VERB
ajst-31202	57	17	uniform	uniform	ADJ
ajst-31202	57	18	amplification	amplification	NOUN
ajst-31202	57	19	and	and	CCONJ
ajst-31202	57	20	accuracy	accuracy	NOUN
ajst-31202	57	21	to	to	PART
ajst-31202	57	22	avoid	avoid	VERB
ajst-31202	57	23	batch	batch	NOUN
ajst-31202	57	24	effects	effect	NOUN
ajst-31202	57	25	.	.	PUNCT
ajst-31202	58	1	finally	finally	ADV
ajst-31202	58	2	,	,	PUNCT
ajst-31202	58	3	the	the	DET
ajst-31202	58	4	library	library	NOUN
ajst-31202	58	5	undergoes	undergo	VERB
ajst-31202	58	6	high	high	ADJ
ajst-31202	58	7	-	-	PUNCT
ajst-31202	58	8	throughput	throughput	NOUN
ajst-31202	58	9	sequencing	sequencing	NOUN
ajst-31202	58	10	,	,	PUNCT
ajst-31202	58	11	allowing	allow	VERB
ajst-31202	58	12	for	for	ADP
ajst-31202	58	13	the	the	DET
ajst-31202	58	14	acquisition	acquisition	NOUN
ajst-31202	58	15	of	of	ADP
ajst-31202	58	16	gene	gene	NOUN
ajst-31202	58	17	expression	expression	NOUN
ajst-31202	58	18	data	datum	NOUN
ajst-31202	58	19	for	for	ADP
ajst-31202	58	20	each	each	DET
ajst-31202	58	21	individual	individual	ADJ
ajst-31202	58	22	cell	cell	NOUN
ajst-31202	58	23	[	[	X
ajst-31202	58	24	13	13	NUM
ajst-31202	58	25	]	]	PUNCT
ajst-31202	58	26	.	.	PUNCT
ajst-31202	59	1	2.3	2.3	NUM
ajst-31202	59	2	.	.	PUNCT
ajst-31202	59	3	comparison	comparison	NOUN
ajst-31202	59	4	of	of	ADP
ajst-31202	59	5	key	key	ADJ
ajst-31202	59	6	technologies	technology	NOUN
ajst-31202	59	7	figure	figure	NOUN
ajst-31202	59	8	2	2	NUM
ajst-31202	59	9	.	.	PUNCT
ajst-31202	59	10	comparison	comparison	NOUN
ajst-31202	59	11	of	of	ADP
ajst-31202	59	12	10x	10x	X
ajst-31202	59	13	genomics	genomic	NOUN
ajst-31202	59	14	and	and	CCONJ
ajst-31202	59	15	drop	drop	NOUN
ajst-31202	59	16	-	-	PUNCT
ajst-31202	59	17	seq	seq	NOUN
ajst-31202	59	18	52	52	NUM
ajst-31202	59	19	in	in	ADP
ajst-31202	59	20	the	the	DET
ajst-31202	59	21	scrna	scrna	NOUN
ajst-31202	59	22	-	-	PUNCT
ajst-31202	59	23	seq	seq	NOUN
ajst-31202	59	24	sequencing	sequence	VERB
ajst-31202	59	25	workflow	workflow	NOUN
ajst-31202	59	26	,	,	PUNCT
ajst-31202	59	27	sequencing	sequence	VERB
ajst-31202	59	28	depth	depth	NOUN
ajst-31202	59	29	and	and	CCONJ
ajst-31202	59	30	quality	quality	NOUN
ajst-31202	59	31	are	be	AUX
ajst-31202	59	32	critical	critical	ADJ
ajst-31202	59	33	considerations	consideration	NOUN
ajst-31202	59	34	.	.	PUNCT
ajst-31202	60	1	taking	take	VERB
ajst-31202	60	2	10x	10x	NUM
ajst-31202	60	3	genomics	genomic	NOUN
ajst-31202	60	4	'	'	PART
ajst-31202	60	5	chromium	chromium	NOUN
ajst-31202	60	6	and	and	CCONJ
ajst-31202	60	7	drop	drop	NOUN
ajst-31202	60	8	-	-	PUNCT
ajst-31202	60	9	seq	seq	NOUN
ajst-31202	60	10	as	as	ADP
ajst-31202	60	11	examples	example	NOUN
ajst-31202	60	12	,	,	PUNCT
ajst-31202	60	13	both	both	PRON
ajst-31202	60	14	are	be	AUX
ajst-31202	60	15	droplet	droplet	ADJ
ajst-31202	60	16	-	-	PUNCT
ajst-31202	60	17	based	base	VERB
ajst-31202	60	18	technologies	technology	NOUN
ajst-31202	60	19	that	that	PRON
ajst-31202	60	20	perform	perform	VERB
ajst-31202	60	21	3	3	NUM
ajst-31202	60	22	'	'	PART
ajst-31202	60	23	end	end	NOUN
ajst-31202	60	24	sequencing	sequence	VERB
ajst-31202	60	25	,	,	PUNCT
ajst-31202	60	26	yet	yet	CCONJ
ajst-31202	60	27	they	they	PRON
ajst-31202	60	28	differ	differ	VERB
ajst-31202	60	29	significantly	significantly	ADV
ajst-31202	60	30	in	in	ADP
ajst-31202	60	31	performance	performance	NOUN
ajst-31202	60	32	and	and	CCONJ
ajst-31202	60	33	application	application	NOUN
ajst-31202	60	34	.	.	PUNCT
ajst-31202	61	1	the	the	DET
ajst-31202	61	2	10x	10x	PROPN
ajst-31202	61	3	genomics	genomics	NOUN
ajst-31202	61	4	chromium	chromium	NOUN
ajst-31202	61	5	system	system	NOUN
ajst-31202	61	6	,	,	PUNCT
ajst-31202	61	7	leveraging	leverage	VERB
ajst-31202	61	8	a	a	DET
ajst-31202	61	9	commercial	commercial	ADJ
ajst-31202	61	10	platform	platform	NOUN
ajst-31202	61	11	,	,	PUNCT
ajst-31202	61	12	utilizes	utilize	VERB
ajst-31202	61	13	microfluidic	microfluidic	ADJ
ajst-31202	61	14	chips	chip	NOUN
ajst-31202	61	15	for	for	ADP
ajst-31202	61	16	efficient	efficient	ADJ
ajst-31202	61	17	single	single	ADJ
ajst-31202	61	18	-	-	PUNCT
ajst-31202	61	19	cell	cell	NOUN
ajst-31202	61	20	encapsulation	encapsulation	NOUN
ajst-31202	61	21	.	.	PUNCT
ajst-31202	62	1	this	this	DET
ajst-31202	62	2	system	system	NOUN
ajst-31202	62	3	supports	support	VERB
ajst-31202	62	4	a	a	DET
ajst-31202	62	5	cell	cell	NOUN
ajst-31202	62	6	throughput	throughput	NOUN
ajst-31202	62	7	of	of	ADP
ajst-31202	62	8	tens	ten	NOUN
ajst-31202	62	9	of	of	ADP
ajst-31202	62	10	thousands	thousand	NOUN
ajst-31202	62	11	(	(	PUNCT
ajst-31202	62	12	500	500	NUM
ajst-31202	62	13	to	to	PART
ajst-31202	62	14	20,000	20,000	NUM
ajst-31202	62	15	cells	cell	NOUN
ajst-31202	62	16	/	/	SYM
ajst-31202	62	17	sample	sample	NOUN
ajst-31202	62	18	)	)	PUNCT
ajst-31202	62	19	,	,	PUNCT
ajst-31202	62	20	with	with	ADP
ajst-31202	62	21	a	a	DET
ajst-31202	62	22	capture	capture	NOUN
ajst-31202	62	23	efficiency	efficiency	NOUN
ajst-31202	62	24	of	of	ADP
ajst-31202	62	25	up	up	ADP
ajst-31202	62	26	to	to	PART
ajst-31202	62	27	65	65	NUM
ajst-31202	62	28	%	%	NOUN
ajst-31202	62	29	and	and	CCONJ
ajst-31202	62	30	an	an	DET
ajst-31202	62	31	effective	effective	ADJ
ajst-31202	62	32	read	read	NOUN
ajst-31202	62	33	ratio	ratio	NOUN
ajst-31202	62	34	of	of	ADP
ajst-31202	62	35	approximately	approximately	ADV
ajst-31202	62	36	75	75	NUM
ajst-31202	62	37	%	%	NOUN
ajst-31202	62	38	.	.	PUNCT
ajst-31202	63	1	it	it	PRON
ajst-31202	63	2	offers	offer	VERB
ajst-31202	63	3	higher	high	ADJ
ajst-31202	63	4	sensitivity	sensitivity	NOUN
ajst-31202	63	5	for	for	ADP
ajst-31202	63	6	detecting	detect	VERB
ajst-31202	63	7	low	low	ADV
ajst-31202	63	8	-	-	PUNCT
ajst-31202	63	9	expressed	express	VERB
ajst-31202	63	10	genes	gene	NOUN
ajst-31202	63	11	,	,	PUNCT
ajst-31202	63	12	a	a	DET
ajst-31202	63	13	low	low	ADJ
ajst-31202	63	14	doublet	doublet	ADJ
ajst-31202	63	15	rate	rate	NOUN
ajst-31202	63	16	(	(	PUNCT
ajst-31202	63	17	0.9%/1000	0.9%/1000	NUM
ajst-31202	63	18	cells	cell	NOUN
ajst-31202	63	19	)	)	PUNCT
ajst-31202	63	20	,	,	PUNCT
ajst-31202	63	21	but	but	CCONJ
ajst-31202	63	22	comes	come	VERB
ajst-31202	63	23	at	at	ADP
ajst-31202	63	24	a	a	DET
ajst-31202	63	25	higher	high	ADJ
ajst-31202	63	26	cost	cost	NOUN
ajst-31202	63	27	(	(	PUNCT
ajst-31202	63	28	$	$	SYM
ajst-31202	63	29	0.87	0.87	NUM
ajst-31202	63	30	per	per	ADP
ajst-31202	63	31	cell	cell	NOUN
ajst-31202	63	32	)	)	PUNCT
ajst-31202	63	33	.	.	PUNCT
ajst-31202	64	1	it	it	PRON
ajst-31202	64	2	is	be	AUX
ajst-31202	64	3	thus	thus	ADV
ajst-31202	64	4	well	well	ADV
ajst-31202	64	5	-	-	PUNCT
ajst-31202	64	6	suited	suit	VERB
ajst-31202	64	7	for	for	ADP
ajst-31202	64	8	complex	complex	ADJ
ajst-31202	64	9	sample	sample	NOUN
ajst-31202	64	10	studies	study	NOUN
ajst-31202	64	11	requiring	require	VERB
ajst-31202	64	12	high	high	ADJ
ajst-31202	64	13	-	-	PUNCT
ajst-31202	64	14	throughput	throughput	NOUN
ajst-31202	64	15	,	,	PUNCT
ajst-31202	64	16	highquality	highquality	NOUN
ajst-31202	64	17	data	datum	NOUN
ajst-31202	64	18	,	,	PUNCT
ajst-31202	64	19	such	such	ADJ
ajst-31202	64	20	as	as	ADP
ajst-31202	64	21	tumor	tumor	NOUN
ajst-31202	64	22	microenvironment	microenvironment	NOUN
ajst-31202	64	23	analyses	analyse	VERB
ajst-31202	64	24	[	[	X
ajst-31202	64	25	14	14	NUM
ajst-31202	64	26	]	]	PUNCT
ajst-31202	64	27	.	.	PUNCT
ajst-31202	65	1	in	in	ADP
ajst-31202	65	2	contrast	contrast	NOUN
ajst-31202	65	3	,	,	PUNCT
ajst-31202	65	4	drop	drop	NOUN
ajst-31202	65	5	-	-	PUNCT
ajst-31202	65	6	seq	seq	NOUN
ajst-31202	65	7	relies	relie	NOUN
ajst-31202	65	8	on	on	ADP
ajst-31202	65	9	a	a	DET
ajst-31202	65	10	laboratory	laboratory	NOUN
ajst-31202	65	11	-	-	PUNCT
ajst-31202	65	12	built	build	VERB
ajst-31202	65	13	system	system	NOUN
ajst-31202	65	14	,	,	PUNCT
ajst-31202	65	15	with	with	ADP
ajst-31202	65	16	lower	low	ADJ
ajst-31202	65	17	throughput	throughput	NOUN
ajst-31202	65	18	(	(	PUNCT
ajst-31202	65	19	about	about	ADV
ajst-31202	65	20	1,000	1,000	NUM
ajst-31202	65	21	to	to	PART
ajst-31202	65	22	10,000	10,000	NUM
ajst-31202	65	23	cells	cell	NOUN
ajst-31202	65	24	)	)	PUNCT
ajst-31202	65	25	,	,	PUNCT
ajst-31202	65	26	a	a	DET
ajst-31202	65	27	capture	capture	NOUN
ajst-31202	65	28	efficiency	efficiency	NOUN
ajst-31202	65	29	and	and	CCONJ
ajst-31202	65	30	effective	effective	ADJ
ajst-31202	65	31	read	read	NOUN
ajst-31202	65	32	ratio	ratio	NOUN
ajst-31202	65	33	of	of	ADP
ajst-31202	65	34	approximately	approximately	ADV
ajst-31202	65	35	30	30	NUM
ajst-31202	65	36	%	%	NOUN
ajst-31202	65	37	,	,	PUNCT
ajst-31202	65	38	and	and	CCONJ
ajst-31202	65	39	insufficient	insufficient	ADJ
ajst-31202	65	40	sensitivity	sensitivity	NOUN
ajst-31202	65	41	for	for	ADP
ajst-31202	65	42	low	low	ADJ
ajst-31202	65	43	-	-	PUNCT
ajst-31202	65	44	abundance	abundance	NOUN
ajst-31202	65	45	transcripts	transcript	NOUN
ajst-31202	65	46	.	.	PUNCT
ajst-31202	66	1	additionally	additionally	ADV
ajst-31202	66	2	,	,	PUNCT
ajst-31202	66	3	it	it	PRON
ajst-31202	66	4	has	have	VERB
ajst-31202	66	5	a	a	DET
ajst-31202	66	6	higher	high	ADJ
ajst-31202	66	7	doublet	doublet	ADJ
ajst-31202	66	8	rate	rate	NOUN
ajst-31202	66	9	,	,	PUNCT
ajst-31202	66	10	but	but	CCONJ
ajst-31202	66	11	is	be	AUX
ajst-31202	66	12	more	more	ADV
ajst-31202	66	13	costeffective	costeffective	ADJ
ajst-31202	66	14	(	(	PUNCT
ajst-31202	66	15	$	$	SYM
ajst-31202	66	16	0.44	0.44	NUM
ajst-31202	66	17	0.47	0.47	NUM
ajst-31202	66	18	per	per	ADP
ajst-31202	66	19	cell	cell	NOUN
ajst-31202	66	20	)	)	PUNCT
ajst-31202	66	21	and	and	CCONJ
ajst-31202	66	22	offers	offer	VERB
ajst-31202	66	23	an	an	DET
ajst-31202	66	24	open	open	ADJ
ajst-31202	66	25	-	-	PUNCT
ajst-31202	66	26	source	source	NOUN
ajst-31202	66	27	workflow	workflow	NOUN
ajst-31202	66	28	,	,	PUNCT
ajst-31202	66	29	making	make	VERB
ajst-31202	66	30	it	it	PRON
ajst-31202	66	31	ideal	ideal	ADJ
ajst-31202	66	32	for	for	ADP
ajst-31202	66	33	exploratory	exploratory	ADJ
ajst-31202	66	34	studies	study	NOUN
ajst-31202	66	35	or	or	CCONJ
ajst-31202	66	36	technical	technical	ADJ
ajst-31202	66	37	development	development	NOUN
ajst-31202	66	38	with	with	ADP
ajst-31202	66	39	budget	budget	NOUN
ajst-31202	66	40	constraints	constraint	NOUN
ajst-31202	66	41	[	[	X
ajst-31202	66	42	15	15	NUM
ajst-31202	66	43	]	]	PUNCT
ajst-31202	66	44	.	.	PUNCT
ajst-31202	67	1	overall	overall	ADJ
ajst-31202	67	2	,	,	PUNCT
ajst-31202	67	3	10x	10x	NUM
ajst-31202	67	4	genomics	genomic	NOUN
ajst-31202	67	5	excels	excel	VERB
ajst-31202	67	6	in	in	ADP
ajst-31202	67	7	data	datum	NOUN
ajst-31202	67	8	quality	quality	NOUN
ajst-31202	67	9	and	and	CCONJ
ajst-31202	67	10	ease	ease	NOUN
ajst-31202	67	11	of	of	ADP
ajst-31202	67	12	use	use	NOUN
ajst-31202	67	13	,	,	PUNCT
ajst-31202	67	14	while	while	SCONJ
ajst-31202	67	15	dropseq	dropseq	NOUN
ajst-31202	67	16	offers	offer	VERB
ajst-31202	67	17	advantages	advantage	NOUN
ajst-31202	67	18	in	in	ADP
ajst-31202	67	19	cost	cost	NOUN
ajst-31202	67	20	-	-	PUNCT
ajst-31202	67	21	effectiveness	effectiveness	NOUN
ajst-31202	67	22	and	and	CCONJ
ajst-31202	67	23	flexibility	flexibility	NOUN
ajst-31202	67	24	.	.	PUNCT
ajst-31202	68	1	the	the	DET
ajst-31202	68	2	choice	choice	NOUN
ajst-31202	68	3	between	between	ADP
ajst-31202	68	4	these	these	DET
ajst-31202	68	5	technologies	technology	NOUN
ajst-31202	68	6	should	should	AUX
ajst-31202	68	7	be	be	AUX
ajst-31202	68	8	based	base	VERB
ajst-31202	68	9	on	on	ADP
ajst-31202	68	10	research	research	NOUN
ajst-31202	68	11	objectives	objective	NOUN
ajst-31202	68	12	,	,	PUNCT
ajst-31202	68	13	sample	sample	NOUN
ajst-31202	68	14	characteristics	characteristic	NOUN
ajst-31202	68	15	,	,	PUNCT
ajst-31202	68	16	and	and	CCONJ
ajst-31202	68	17	budget	budget	NOUN
ajst-31202	68	18	considerations	consideration	NOUN
ajst-31202	68	19	.	.	PUNCT
ajst-31202	69	1	the	the	DET
ajst-31202	69	2	flexible	flexible	ADJ
ajst-31202	69	3	integration	integration	NOUN
ajst-31202	69	4	of	of	ADP
ajst-31202	69	5	these	these	DET
ajst-31202	69	6	technologies	technology	NOUN
ajst-31202	69	7	and	and	CCONJ
ajst-31202	69	8	workflows	workflow	NOUN
ajst-31202	69	9	enables	enable	VERB
ajst-31202	69	10	scrna	scrna	NOUN
ajst-31202	69	11	-	-	PUNCT
ajst-31202	69	12	seq	seq	NOUN
ajst-31202	69	13	to	to	PART
ajst-31202	69	14	provide	provide	VERB
ajst-31202	69	15	deep	deep	ADJ
ajst-31202	69	16	insights	insight	NOUN
ajst-31202	69	17	into	into	ADP
ajst-31202	69	18	cellular	cellular	ADJ
ajst-31202	69	19	heterogeneity	heterogeneity	NOUN
ajst-31202	69	20	,	,	PUNCT
ajst-31202	69	21	functional	functional	ADJ
ajst-31202	69	22	differences	difference	NOUN
ajst-31202	69	23	,	,	PUNCT
ajst-31202	69	24	and	and	CCONJ
ajst-31202	69	25	developmental	developmental	ADJ
ajst-31202	69	26	dynamics	dynamic	NOUN
ajst-31202	69	27	,	,	PUNCT
ajst-31202	69	28	thus	thus	ADV
ajst-31202	69	29	opening	open	VERB
ajst-31202	69	30	new	new	ADJ
ajst-31202	69	31	perspectives	perspective	NOUN
ajst-31202	69	32	in	in	ADP
ajst-31202	69	33	biological	biological	ADJ
ajst-31202	69	34	research	research	NOUN
ajst-31202	69	35	.	.	PUNCT
ajst-31202	70	1	3	3	X
ajst-31202	70	2	.	.	X
ajst-31202	70	3	st	st	PROPN
ajst-31202	70	4	(	(	PUNCT
ajst-31202	70	5	spatial	spatial	ADJ
ajst-31202	70	6	transcriptomics	transcriptomic	NOUN
ajst-31202	70	7	)	)	PUNCT
ajst-31202	70	8	3.1	3.1	NUM
ajst-31202	70	9	.	.	PUNCT
ajst-31202	71	1	historical	historical	ADJ
ajst-31202	71	2	development	development	NOUN
ajst-31202	71	3	of	of	ADP
ajst-31202	71	4	spatial	spatial	ADJ
ajst-31202	71	5	transcriptomics	transcriptomic	NOUN
ajst-31202	71	6	(	(	PUNCT
ajst-31202	71	7	st	st	PROPN
ajst-31202	71	8	)	)	PUNCT
ajst-31202	71	9	the	the	DET
ajst-31202	71	10	development	development	NOUN
ajst-31202	71	11	of	of	ADP
ajst-31202	71	12	spatial	spatial	ADJ
ajst-31202	71	13	transcriptomics	transcriptomic	NOUN
ajst-31202	71	14	(	(	PUNCT
ajst-31202	71	15	st	st	NOUN
ajst-31202	71	16	)	)	PUNCT
ajst-31202	71	17	dates	date	VERB
ajst-31202	71	18	back	back	ADV
ajst-31202	71	19	to	to	ADP
ajst-31202	71	20	the	the	DET
ajst-31202	71	21	1970s	1970	NOUN
ajst-31202	71	22	,	,	PUNCT
ajst-31202	71	23	when	when	SCONJ
ajst-31202	71	24	techniques	technique	NOUN
ajst-31202	71	25	such	such	ADJ
ajst-31202	71	26	as	as	ADP
ajst-31202	71	27	in	in	ADP
ajst-31202	71	28	situ	situ	ADJ
ajst-31202	71	29	hybridization	hybridization	NOUN
ajst-31202	71	30	(	(	PUNCT
ajst-31202	71	31	ish	ish	PROPN
ajst-31202	71	32	)	)	PUNCT
ajst-31202	71	33	and	and	CCONJ
ajst-31202	71	34	laser	laser	NOUN
ajst-31202	71	35	capture	capture	NOUN
ajst-31202	71	36	microdissection	microdissection	NOUN
ajst-31202	71	37	(	(	PUNCT
ajst-31202	71	38	lcm	lcm	NOUN
ajst-31202	71	39	)	)	PUNCT
ajst-31202	71	40	were	be	AUX
ajst-31202	71	41	primarily	primarily	ADV
ajst-31202	71	42	used	use	VERB
ajst-31202	71	43	to	to	PART
ajst-31202	71	44	visualize	visualize	VERB
ajst-31202	71	45	and	and	CCONJ
ajst-31202	71	46	capture	capture	VERB
ajst-31202	71	47	gene	gene	NOUN
ajst-31202	71	48	expression	expression	NOUN
ajst-31202	71	49	in	in	ADP
ajst-31202	71	50	spatial	spatial	ADJ
ajst-31202	71	51	contexts	contexts	NOUN
ajst-31202	71	52	[	[	X
ajst-31202	71	53	15	15	NUM
ajst-31202	71	54	]	]	PUNCT
ajst-31202	71	55	.	.	PUNCT
ajst-31202	72	1	although	although	SCONJ
ajst-31202	72	2	these	these	DET
ajst-31202	72	3	early	early	ADJ
ajst-31202	72	4	methods	method	NOUN
ajst-31202	72	5	had	have	VERB
ajst-31202	72	6	some	some	DET
ajst-31202	72	7	spatial	spatial	ADJ
ajst-31202	72	8	resolution	resolution	NOUN
ajst-31202	72	9	,	,	PUNCT
ajst-31202	72	10	they	they	PRON
ajst-31202	72	11	were	be	AUX
ajst-31202	72	12	limited	limit	VERB
ajst-31202	72	13	by	by	ADP
ajst-31202	72	14	low	low	ADJ
ajst-31202	72	15	throughput	throughput	NOUN
ajst-31202	72	16	and	and	CCONJ
ajst-31202	72	17	could	could	AUX
ajst-31202	72	18	only	only	ADV
ajst-31202	72	19	detect	detect	VERB
ajst-31202	72	20	a	a	DET
ajst-31202	72	21	small	small	ADJ
ajst-31202	72	22	number	number	NOUN
ajst-31202	72	23	of	of	ADP
ajst-31202	72	24	known	know	VERB
ajst-31202	72	25	genes	gene	NOUN
ajst-31202	72	26	,	,	PUNCT
ajst-31202	72	27	representing	represent	VERB
ajst-31202	72	28	the	the	DET
ajst-31202	72	29	earliest	early	ADJ
ajst-31202	72	30	form	form	NOUN
ajst-31202	72	31	of	of	ADP
ajst-31202	72	32	st	st	PROPN
ajst-31202	72	33	.	.	PROPN
ajst-31202	73	1	it	it	PRON
ajst-31202	73	2	was	be	AUX
ajst-31202	73	3	not	not	PART
ajst-31202	73	4	until	until	ADP
ajst-31202	73	5	2010	2010	NUM
ajst-31202	73	6	that	that	PRON
ajst-31202	73	7	st	st	PROPN
ajst-31202	73	8	achieved	achieve	VERB
ajst-31202	73	9	high	high	ADJ
ajst-31202	73	10	-	-	PUNCT
ajst-31202	73	11	throughput	throughput	NOUN
ajst-31202	73	12	,	,	PUNCT
ajst-31202	73	13	high	high	ADJ
ajst-31202	73	14	-	-	PUNCT
ajst-31202	73	15	resolution	resolution	NOUN
ajst-31202	73	16	,	,	PUNCT
ajst-31202	73	17	and	and	CCONJ
ajst-31202	73	18	highdiversity	highdiversity	NOUN
ajst-31202	73	19	gene	gene	NOUN
ajst-31202	73	20	expression	expression	NOUN
ajst-31202	73	21	detection	detection	NOUN
ajst-31202	73	22	in	in	ADP
ajst-31202	73	23	spatial	spatial	ADJ
ajst-31202	73	24	contexts	context	NOUN
ajst-31202	74	1	[	[	X
ajst-31202	74	2	16	16	NUM
ajst-31202	74	3	]	]	PUNCT
ajst-31202	74	4	.	.	PUNCT
ajst-31202	75	1	researchers	researcher	NOUN
ajst-31202	75	2	generally	generally	ADV
ajst-31202	75	3	categorize	categorize	VERB
ajst-31202	75	4	st	st	PROPN
ajst-31202	75	5	into	into	ADP
ajst-31202	75	6	two	two	NUM
ajst-31202	75	7	main	main	ADJ
ajst-31202	75	8	approaches	approach	NOUN
ajst-31202	75	9	.	.	PUNCT
ajst-31202	76	1	the	the	DET
ajst-31202	76	2	first	first	ADJ
ajst-31202	76	3	category	category	NOUN
ajst-31202	76	4	involves	involve	VERB
ajst-31202	76	5	large	large	ADJ
ajst-31202	76	6	-	-	PUNCT
ajst-31202	76	7	scale	scale	NOUN
ajst-31202	76	8	next	next	ADJ
ajst-31202	76	9	-	-	PUNCT
ajst-31202	76	10	generation	generation	NOUN
ajst-31202	76	11	sequencing	sequencing	NOUN
ajst-31202	76	12	(	(	PUNCT
ajst-31202	76	13	ngs)-based	ngs)-base	VERB
ajst-31202	76	14	technologies	technology	NOUN
ajst-31202	76	15	,	,	PUNCT
ajst-31202	76	16	where	where	SCONJ
ajst-31202	76	17	positional	positional	ADJ
ajst-31202	76	18	information	information	NOUN
ajst-31202	76	19	is	be	AUX
ajst-31202	76	20	encoded	encode	VERB
ajst-31202	76	21	onto	onto	ADP
ajst-31202	76	22	transcripts	transcript	NOUN
ajst-31202	76	23	prior	prior	ADV
ajst-31202	76	24	to	to	ADP
ajst-31202	76	25	sequencing	sequence	VERB
ajst-31202	76	26	.	.	PUNCT
ajst-31202	77	1	these	these	DET
ajst-31202	77	2	methods	method	NOUN
ajst-31202	77	3	include	include	VERB
ajst-31202	77	4	microarray	microarray	NOUN
ajst-31202	77	5	slides	slide	NOUN
ajst-31202	77	6	with	with	ADP
ajst-31202	77	7	positional	positional	ADJ
ajst-31202	77	8	barcodes	barcode	NOUN
ajst-31202	77	9	to	to	PART
ajst-31202	77	10	capture	capture	VERB
ajst-31202	77	11	mrna	mrna	PROPN
ajst-31202	77	12	from	from	ADP
ajst-31202	77	13	tissues	tissue	NOUN
ajst-31202	77	14	for	for	ADP
ajst-31202	77	15	st	st	PROPN
ajst-31202	77	16	,	,	PUNCT
ajst-31202	77	17	slides	slide	VERB
ajst-31202	77	18	with	with	ADP
ajst-31202	77	19	random	random	ADJ
ajst-31202	77	20	barcode	barcode	NOUN
ajst-31202	77	21	beads	bead	NOUN
ajst-31202	77	22	to	to	PART
ajst-31202	77	23	capture	capture	VERB
ajst-31202	77	24	mrna	mrna	PROPN
ajst-31202	77	25	for	for	ADP
ajst-31202	77	26	slide	slide	NOUN
ajst-31202	77	27	-	-	PUNCT
ajst-31202	77	28	seq	seq	NOUN
ajst-31202	77	29	,	,	PUNCT
ajst-31202	77	30	and	and	CCONJ
ajst-31202	77	31	the	the	DET
ajst-31202	77	32	geomx	geomx	ADJ
ajst-31202	77	33	digital	digital	ADJ
ajst-31202	77	34	spatial	spatial	ADJ
ajst-31202	77	35	profiler	profiler	NOUN
ajst-31202	77	36	(	(	PUNCT
ajst-31202	77	37	dsp	dsp	NOUN
ajst-31202	77	38	)	)	PUNCT
ajst-31202	77	39	,	,	PUNCT
ajst-31202	77	40	which	which	PRON
ajst-31202	77	41	uses	use	VERB
ajst-31202	77	42	ultraviolet	ultraviolet	ADJ
ajst-31202	77	43	light	light	NOUN
ajst-31202	77	44	to	to	PART
ajst-31202	77	45	release	release	VERB
ajst-31202	77	46	photocleavable	photocleavable	ADJ
ajst-31202	77	47	gene	gene	NOUN
ajst-31202	77	48	tags	tag	NOUN
ajst-31202	77	49	from	from	ADP
ajst-31202	77	50	regions	region	NOUN
ajst-31202	77	51	of	of	ADP
ajst-31202	77	52	interest	interest	NOUN
ajst-31202	77	53	(	(	PUNCT
ajst-31202	77	54	rois	rois	PROPN
ajst-31202	77	55	)	)	PUNCT
ajst-31202	77	56	for	for	ADP
ajst-31202	77	57	sequencing	sequencing	NOUN
ajst-31202	77	58	and	and	CCONJ
ajst-31202	77	59	quantification	quantification	NOUN
ajst-31202	77	60	[	[	X
ajst-31202	77	61	3	3	NUM
ajst-31202	77	62	]	]	PUNCT
ajst-31202	77	63	.	.	PUNCT
ajst-31202	78	1	the	the	DET
ajst-31202	78	2	second	second	ADJ
ajst-31202	78	3	category	category	NOUN
ajst-31202	78	4	is	be	AUX
ajst-31202	78	5	imaging	imaging	NOUN
ajst-31202	78	6	-	-	PUNCT
ajst-31202	78	7	based	base	VERB
ajst-31202	78	8	techniques	technique	NOUN
ajst-31202	78	9	,	,	PUNCT
ajst-31202	78	10	typically	typically	ADV
ajst-31202	78	11	employing	employ	VERB
ajst-31202	78	12	specific	specific	ADJ
ajst-31202	78	13	probes	probe	NOUN
ajst-31202	78	14	to	to	PART
ajst-31202	78	15	amplify	amplify	VERB
ajst-31202	78	16	and	and	CCONJ
ajst-31202	78	17	sequence	sequence	NOUN
ajst-31202	78	18	transcripts	transcript	NOUN
ajst-31202	78	19	within	within	ADP
ajst-31202	78	20	tissues	tissue	NOUN
ajst-31202	78	21	.	.	PUNCT
ajst-31202	79	1	these	these	DET
ajst-31202	79	2	methods	method	NOUN
ajst-31202	79	3	include	include	VERB
ajst-31202	79	4	in	in	ADP
ajst-31202	79	5	situ	situ	ADJ
ajst-31202	79	6	hybridization	hybridization	NOUN
ajst-31202	79	7	(	(	PUNCT
ajst-31202	79	8	ish	ish	PROPN
ajst-31202	79	9	)	)	PUNCT
ajst-31202	79	10	,	,	PUNCT
ajst-31202	79	11	which	which	PRON
ajst-31202	79	12	uses	use	VERB
ajst-31202	79	13	fluorescent	fluorescent	ADJ
ajst-31202	79	14	probes	probe	NOUN
ajst-31202	79	15	for	for	ADP
ajst-31202	79	16	continuous	continuous	ADJ
ajst-31202	79	17	hybridization	hybridization	NOUN
ajst-31202	79	18	and	and	CCONJ
ajst-31202	79	19	imaging	imaging	NOUN
ajst-31202	79	20	of	of	ADP
ajst-31202	79	21	transcripts	transcript	NOUN
ajst-31202	79	22	within	within	ADP
ajst-31202	79	23	tissues	tissue	NOUN
ajst-31202	79	24	,	,	PUNCT
ajst-31202	79	25	and	and	CCONJ
ajst-31202	79	26	in	in	ADP
ajst-31202	79	27	situ	situ	ADJ
ajst-31202	79	28	sequencing	sequence	VERB
ajst-31202	79	29	(	(	PUNCT
ajst-31202	79	30	iss	iss	PROPN
ajst-31202	79	31	)	)	PUNCT
ajst-31202	79	32	,	,	PUNCT
ajst-31202	79	33	which	which	PRON
ajst-31202	79	34	enables	enable	VERB
ajst-31202	79	35	direct	direct	ADJ
ajst-31202	79	36	sequencing	sequencing	NOUN
ajst-31202	79	37	within	within	ADP
ajst-31202	79	38	tissues	tissue	NOUN
ajst-31202	79	39	[	[	X
ajst-31202	79	40	17	17	NUM
ajst-31202	79	41	]	]	SYM
ajst-31202	79	42	.	.	PUNCT
ajst-31202	80	1	3.2	3.2	NUM
ajst-31202	80	2	.	.	PUNCT
ajst-31202	80	3	workflow	workflow	NOUN
ajst-31202	80	4	of	of	ADP
ajst-31202	80	5	st	st	PROPN
ajst-31202	80	6	figure	figure	NOUN
ajst-31202	80	7	3	3	PROPN
ajst-31202	80	8	.	.	PUNCT
ajst-31202	80	9	spatial	spatial	ADJ
ajst-31202	80	10	transcriptomics	transcriptomic	NOUN
ajst-31202	80	11	sequencing	sequence	VERB
ajst-31202	80	12	workflow	workflow	NOUN
ajst-31202	80	13	53	53	NUM
ajst-31202	80	14	the	the	DET
ajst-31202	80	15	basic	basic	ADJ
ajst-31202	80	16	workflow	workflow	NOUN
ajst-31202	80	17	of	of	ADP
ajst-31202	80	18	spatial	spatial	ADJ
ajst-31202	80	19	transcriptomics	transcriptomic	NOUN
ajst-31202	80	20	(	(	PUNCT
ajst-31202	80	21	st	st	NOUN
ajst-31202	80	22	)	)	PUNCT
ajst-31202	80	23	can	can	AUX
ajst-31202	80	24	be	be	AUX
ajst-31202	80	25	divided	divide	VERB
ajst-31202	80	26	into	into	ADP
ajst-31202	80	27	several	several	ADJ
ajst-31202	80	28	key	key	ADJ
ajst-31202	80	29	steps	step	NOUN
ajst-31202	80	30	.	.	PUNCT
ajst-31202	81	1	the	the	DET
ajst-31202	81	2	first	first	ADJ
ajst-31202	81	3	step	step	NOUN
ajst-31202	81	4	involves	involve	VERB
ajst-31202	81	5	sample	sample	NOUN
ajst-31202	81	6	preparation	preparation	NOUN
ajst-31202	81	7	,	,	PUNCT
ajst-31202	81	8	where	where	SCONJ
ajst-31202	81	9	fresh	fresh	ADJ
ajst-31202	81	10	tissue	tissue	NOUN
ajst-31202	81	11	samples	sample	NOUN
ajst-31202	81	12	are	be	AUX
ajst-31202	81	13	rapidly	rapidly	ADV
ajst-31202	81	14	frozen	frozen	ADJ
ajst-31202	81	15	and	and	CCONJ
ajst-31202	81	16	embedded	embed	VERB
ajst-31202	81	17	in	in	ADP
ajst-31202	81	18	oct	oct	PROPN
ajst-31202	81	19	(	(	PUNCT
ajst-31202	81	20	optimal	optimal	ADJ
ajst-31202	81	21	cutting	cut	VERB
ajst-31202	81	22	temperature	temperature	NOUN
ajst-31202	81	23	)	)	PUNCT
ajst-31202	81	24	compound	compound	NOUN
ajst-31202	81	25	.	.	PUNCT
ajst-31202	82	1	the	the	DET
ajst-31202	82	2	samples	sample	NOUN
ajst-31202	82	3	are	be	AUX
ajst-31202	82	4	then	then	ADV
ajst-31202	82	5	sectioned	section	VERB
ajst-31202	82	6	into	into	ADP
ajst-31202	82	7	approximately	approximately	ADV
ajst-31202	82	8	10	10	NUM
ajst-31202	82	9	m	m	NOUN
ajst-31202	82	10	thick	thick	ADJ
ajst-31202	82	11	slices	slice	NOUN
ajst-31202	82	12	using	use	VERB
ajst-31202	82	13	a	a	DET
ajst-31202	82	14	cryostat	cryostat	NOUN
ajst-31202	82	15	and	and	CCONJ
ajst-31202	82	16	placed	place	VERB
ajst-31202	82	17	onto	onto	ADP
ajst-31202	82	18	a	a	DET
ajst-31202	82	19	chip	chip	NOUN
ajst-31202	82	20	containing	contain	VERB
ajst-31202	82	21	spatially	spatially	ADV
ajst-31202	82	22	encoded	encode	VERB
ajst-31202	82	23	probes	probe	NOUN
ajst-31202	82	24	.	.	PUNCT
ajst-31202	83	1	the	the	DET
ajst-31202	83	2	next	next	ADJ
ajst-31202	83	3	step	step	NOUN
ajst-31202	83	4	is	be	AUX
ajst-31202	83	5	fixation	fixation	NOUN
ajst-31202	83	6	and	and	CCONJ
ajst-31202	83	7	staining	stain	VERB
ajst-31202	83	8	,	,	PUNCT
ajst-31202	83	9	where	where	SCONJ
ajst-31202	83	10	the	the	DET
ajst-31202	83	11	chip	chip	NOUN
ajst-31202	83	12	is	be	AUX
ajst-31202	83	13	fixed	fix	VERB
ajst-31202	83	14	with	with	ADP
ajst-31202	83	15	methanol	methanol	NOUN
ajst-31202	83	16	for	for	ADP
ajst-31202	83	17	a	a	DET
ajst-31202	83	18	certain	certain	ADJ
ajst-31202	83	19	period	period	NOUN
ajst-31202	83	20	,	,	PUNCT
ajst-31202	83	21	followed	follow	VERB
ajst-31202	83	22	by	by	ADP
ajst-31202	83	23	h&e	h&e	PROPN
ajst-31202	83	24	(	(	PUNCT
ajst-31202	83	25	hematoxylin	hematoxylin	NOUN
ajst-31202	83	26	and	and	CCONJ
ajst-31202	83	27	eosin	eosin	NOUN
ajst-31202	83	28	)	)	PUNCT
ajst-31202	83	29	staining	stain	VERB
ajst-31202	83	30	to	to	PART
ajst-31202	83	31	observe	observe	VERB
ajst-31202	83	32	tissue	tissue	NOUN
ajst-31202	83	33	structure	structure	NOUN
ajst-31202	83	34	and	and	CCONJ
ajst-31202	83	35	morphology	morphology	NOUN
ajst-31202	83	36	.	.	PUNCT
ajst-31202	84	1	subsequently	subsequently	ADV
ajst-31202	84	2	,	,	PUNCT
ajst-31202	84	3	the	the	DET
ajst-31202	84	4	chip	chip	NOUN
ajst-31202	84	5	is	be	AUX
ajst-31202	84	6	incubated	incubate	VERB
ajst-31202	84	7	in	in	ADP
ajst-31202	84	8	a	a	DET
ajst-31202	84	9	permeabilization	permeabilization	NOUN
ajst-31202	84	10	solution	solution	NOUN
ajst-31202	84	11	to	to	PART
ajst-31202	84	12	release	release	VERB
ajst-31202	84	13	mrna	mrna	NOUN
ajst-31202	84	14	from	from	ADP
ajst-31202	84	15	the	the	DET
ajst-31202	84	16	cells	cell	NOUN
ajst-31202	84	17	,	,	PUNCT
ajst-31202	84	18	which	which	PRON
ajst-31202	84	19	binds	bind	VERB
ajst-31202	84	20	to	to	ADP
ajst-31202	84	21	the	the	DET
ajst-31202	84	22	corresponding	correspond	VERB
ajst-31202	84	23	probes	probe	NOUN
ajst-31202	84	24	.	.	PUNCT
ajst-31202	85	1	fluorescently	fluorescently	ADV
ajst-31202	85	2	labeled	label	VERB
ajst-31202	85	3	reverse	reverse	ADJ
ajst-31202	85	4	transcriptase	transcriptase	NOUN
ajst-31202	85	5	is	be	AUX
ajst-31202	85	6	then	then	ADV
ajst-31202	85	7	used	use	VERB
ajst-31202	85	8	for	for	ADP
ajst-31202	85	9	cdna	cdna	PROPN
ajst-31202	85	10	synthesis	synthesis	NOUN
ajst-31202	85	11	.	.	PUNCT
ajst-31202	86	1	the	the	DET
ajst-31202	86	2	following	follow	VERB
ajst-31202	86	3	step	step	NOUN
ajst-31202	86	4	involves	involve	VERB
ajst-31202	86	5	incubating	incubate	VERB
ajst-31202	86	6	the	the	DET
ajst-31202	86	7	chip	chip	NOUN
ajst-31202	86	8	in	in	ADP
ajst-31202	86	9	a	a	DET
ajst-31202	86	10	tissue	tissue	NOUN
ajst-31202	86	11	removal	removal	NOUN
ajst-31202	86	12	solution	solution	NOUN
ajst-31202	86	13	to	to	PART
ajst-31202	86	14	remove	remove	VERB
ajst-31202	86	15	residual	residual	ADJ
ajst-31202	86	16	tissue	tissue	NOUN
ajst-31202	86	17	and	and	CCONJ
ajst-31202	86	18	oct	oct	PROPN
ajst-31202	86	19	.	.	PUNCT
ajst-31202	87	1	the	the	DET
ajst-31202	87	2	cdna	cdna	PROPN
ajst-31202	87	3	is	be	AUX
ajst-31202	87	4	then	then	ADV
ajst-31202	87	5	amplified	amplify	VERB
ajst-31202	87	6	using	use	VERB
ajst-31202	87	7	pcr	pcr	NOUN
ajst-31202	87	8	.	.	PUNCT
ajst-31202	88	1	finally	finally	ADV
ajst-31202	88	2	,	,	PUNCT
ajst-31202	88	3	the	the	DET
ajst-31202	88	4	corresponding	correspond	VERB
ajst-31202	88	5	sequencing	sequence	VERB
ajst-31202	88	6	library	library	NOUN
ajst-31202	88	7	is	be	AUX
ajst-31202	88	8	prepared	prepare	VERB
ajst-31202	88	9	,	,	PUNCT
ajst-31202	88	10	typically	typically	ADV
ajst-31202	88	11	through	through	ADP
ajst-31202	88	12	steps	step	NOUN
ajst-31202	88	13	including	include	VERB
ajst-31202	88	14	end	end	NOUN
ajst-31202	88	15	-	-	PUNCT
ajst-31202	88	16	repair	repair	NOUN
ajst-31202	88	17	,	,	PUNCT
ajst-31202	88	18	a	a	DET
ajst-31202	88	19	-	-	PUNCT
ajst-31202	88	20	tailing	tail	VERB
ajst-31202	88	21	,	,	PUNCT
ajst-31202	88	22	adapter	adapter	NOUN
ajst-31202	88	23	ligation	ligation	NOUN
ajst-31202	88	24	,	,	PUNCT
ajst-31202	88	25	and	and	CCONJ
ajst-31202	88	26	indexing	indexing	NOUN
ajst-31202	88	27	.	.	PUNCT
ajst-31202	89	1	the	the	DET
ajst-31202	89	2	library	library	NOUN
ajst-31202	89	3	is	be	AUX
ajst-31202	89	4	then	then	ADV
ajst-31202	89	5	sequenced	sequence	VERB
ajst-31202	89	6	using	use	VERB
ajst-31202	89	7	a	a	DET
ajst-31202	89	8	highthroughput	highthroughput	ADJ
ajst-31202	89	9	sequencing	sequence	VERB
ajst-31202	89	10	platform	platform	NOUN
ajst-31202	89	11	[	[	X
ajst-31202	89	12	3	3	NUM
ajst-31202	89	13	]	]	PUNCT
ajst-31202	89	14	.	.	PUNCT
ajst-31202	90	1	4	4	X
ajst-31202	90	2	.	.	X
ajst-31202	90	3	conclusion	conclusion	NOUN
ajst-31202	90	4	4.1	4.1	NUM
ajst-31202	90	5	.	.	PUNCT
ajst-31202	91	1	advantages	advantage	NOUN
ajst-31202	91	2	and	and	CCONJ
ajst-31202	91	3	applications	application	NOUN
ajst-31202	91	4	of	of	ADP
ajst-31202	91	5	scrnaseq	scrnaseq	NOUN
ajst-31202	91	6	both	both	CCONJ
ajst-31202	91	7	scrna	scrna	NOUN
ajst-31202	91	8	-	-	PUNCT
ajst-31202	91	9	seq	seq	NOUN
ajst-31202	91	10	and	and	CCONJ
ajst-31202	91	11	st	st	PROPN
ajst-31202	91	12	have	have	VERB
ajst-31202	91	13	their	their	PRON
ajst-31202	91	14	respective	respective	ADJ
ajst-31202	91	15	advantages	advantage	NOUN
ajst-31202	91	16	and	and	CCONJ
ajst-31202	91	17	limitations	limitation	NOUN
ajst-31202	91	18	,	,	PUNCT
ajst-31202	91	19	and	and	CCONJ
ajst-31202	91	20	their	their	PRON
ajst-31202	91	21	applications	application	NOUN
ajst-31202	91	22	have	have	AUX
ajst-31202	91	23	evolved	evolve	VERB
ajst-31202	91	24	accordingly	accordingly	ADV
ajst-31202	91	25	.	.	PUNCT
ajst-31202	92	1	for	for	ADP
ajst-31202	92	2	scrna	scrna	NOUN
ajst-31202	92	3	-	-	PUNCT
ajst-31202	92	4	seq	seq	NOUN
ajst-31202	92	5	,	,	PUNCT
ajst-31202	92	6	its	its	PRON
ajst-31202	92	7	high	high	ADJ
ajst-31202	92	8	resolution	resolution	NOUN
ajst-31202	92	9	allows	allow	VERB
ajst-31202	92	10	for	for	ADP
ajst-31202	92	11	the	the	DET
ajst-31202	92	12	avoidance	avoidance	NOUN
ajst-31202	92	13	of	of	ADP
ajst-31202	92	14	the	the	DET
ajst-31202	92	15	homogenization	homogenization	NOUN
ajst-31202	92	16	effect	effect	NOUN
ajst-31202	92	17	of	of	ADP
ajst-31202	92	18	mixed	mixed	ADJ
ajst-31202	92	19	samples	sample	NOUN
ajst-31202	92	20	in	in	ADP
ajst-31202	92	21	traditional	traditional	ADJ
ajst-31202	92	22	sequencing	sequence	VERB
ajst-31202	92	23	methods	method	NOUN
ajst-31202	92	24	,	,	PUNCT
ajst-31202	92	25	preserving	preserve	VERB
ajst-31202	92	26	the	the	DET
ajst-31202	92	27	original	original	ADJ
ajst-31202	92	28	and	and	CCONJ
ajst-31202	92	29	authentic	authentic	ADJ
ajst-31202	92	30	gene	gene	NOUN
ajst-31202	92	31	expression	expression	NOUN
ajst-31202	92	32	information	information	NOUN
ajst-31202	92	33	of	of	ADP
ajst-31202	92	34	each	each	DET
ajst-31202	92	35	individual	individual	ADJ
ajst-31202	92	36	cell	cell	NOUN
ajst-31202	92	37	,	,	PUNCT
ajst-31202	92	38	thereby	thereby	ADV
ajst-31202	92	39	reflecting	reflect	VERB
ajst-31202	92	40	the	the	DET
ajst-31202	92	41	cell	cell	NOUN
ajst-31202	92	42	s	s	NOUN
ajst-31202	92	43	functions	function	NOUN
ajst-31202	92	44	and	and	CCONJ
ajst-31202	92	45	characteristics	characteristic	NOUN
ajst-31202	92	46	.	.	PUNCT
ajst-31202	93	1	in	in	ADP
ajst-31202	93	2	addition	addition	NOUN
ajst-31202	93	3	,	,	PUNCT
ajst-31202	93	4	scrna	scrna	NOUN
ajst-31202	93	5	-	-	PUNCT
ajst-31202	93	6	seq	seq	NOUN
ajst-31202	93	7	enables	enable	VERB
ajst-31202	93	8	high	high	ADJ
ajst-31202	93	9	-	-	PUNCT
ajst-31202	93	10	throughput	throughput	NOUN
ajst-31202	93	11	sequencing	sequencing	NOUN
ajst-31202	93	12	,	,	PUNCT
ajst-31202	93	13	which	which	PRON
ajst-31202	93	14	allows	allow	VERB
ajst-31202	93	15	for	for	ADP
ajst-31202	93	16	the	the	DET
ajst-31202	93	17	simultaneous	simultaneous	ADJ
ajst-31202	93	18	analysis	analysis	NOUN
ajst-31202	93	19	of	of	ADP
ajst-31202	93	20	thousands	thousand	NOUN
ajst-31202	93	21	to	to	ADP
ajst-31202	93	22	tens	ten	NOUN
ajst-31202	93	23	of	of	ADP
ajst-31202	93	24	thousands	thousand	NOUN
ajst-31202	93	25	of	of	ADP
ajst-31202	93	26	single	single	ADJ
ajst-31202	93	27	cells	cell	NOUN
ajst-31202	93	28	,	,	PUNCT
ajst-31202	93	29	thereby	thereby	ADV
ajst-31202	93	30	enhancing	enhance	VERB
ajst-31202	93	31	sequencing	sequencing	NOUN
ajst-31202	93	32	efficiency	efficiency	NOUN
ajst-31202	93	33	and	and	CCONJ
ajst-31202	93	34	coverage	coverage	NOUN
ajst-31202	93	35	.	.	PUNCT
ajst-31202	94	1	this	this	PRON
ajst-31202	94	2	facilitates	facilitate	VERB
ajst-31202	94	3	the	the	DET
ajst-31202	94	4	discovery	discovery	NOUN
ajst-31202	94	5	of	of	ADP
ajst-31202	94	6	rare	rare	ADJ
ajst-31202	94	7	cells	cell	NOUN
ajst-31202	94	8	and	and	CCONJ
ajst-31202	94	9	novel	novel	ADJ
ajst-31202	94	10	cell	cell	NOUN
ajst-31202	94	11	subtypes	subtype	NOUN
ajst-31202	94	12	[	[	X
ajst-31202	94	13	18	18	NUM
ajst-31202	94	14	]	]	PUNCT
ajst-31202	94	15	.	.	PUNCT
ajst-31202	95	1	its	its	PRON
ajst-31202	95	2	high	high	ADJ
ajst-31202	95	3	flexibility	flexibility	NOUN
ajst-31202	95	4	is	be	AUX
ajst-31202	95	5	another	another	DET
ajst-31202	95	6	key	key	ADJ
ajst-31202	95	7	advantage	advantage	NOUN
ajst-31202	95	8	,	,	PUNCT
ajst-31202	95	9	making	make	VERB
ajst-31202	95	10	it	it	PRON
ajst-31202	95	11	adaptable	adaptable	ADJ
ajst-31202	95	12	to	to	ADP
ajst-31202	95	13	various	various	ADJ
ajst-31202	95	14	sample	sample	NOUN
ajst-31202	95	15	types	type	NOUN
ajst-31202	95	16	such	such	ADJ
ajst-31202	95	17	as	as	ADP
ajst-31202	95	18	blood	blood	NOUN
ajst-31202	95	19	,	,	PUNCT
ajst-31202	95	20	tissue	tissue	NOUN
ajst-31202	95	21	,	,	PUNCT
ajst-31202	95	22	and	and	CCONJ
ajst-31202	95	23	cultured	cultured	ADJ
ajst-31202	95	24	cells	cell	NOUN
ajst-31202	95	25	.	.	PUNCT
ajst-31202	96	1	it	it	PRON
ajst-31202	96	2	can	can	AUX
ajst-31202	96	3	also	also	ADV
ajst-31202	96	4	be	be	AUX
ajst-31202	96	5	combined	combine	VERB
ajst-31202	96	6	with	with	ADP
ajst-31202	96	7	other	other	ADJ
ajst-31202	96	8	omics	omic	NOUN
ajst-31202	96	9	data	datum	NOUN
ajst-31202	96	10	,	,	PUNCT
ajst-31202	96	11	such	such	ADJ
ajst-31202	96	12	as	as	ADP
ajst-31202	96	13	genomics	genomic	NOUN
ajst-31202	96	14	,	,	PUNCT
ajst-31202	96	15	epigenomics	epigenomic	NOUN
ajst-31202	96	16	,	,	PUNCT
ajst-31202	96	17	and	and	CCONJ
ajst-31202	96	18	proteomics	proteomic	NOUN
ajst-31202	96	19	,	,	PUNCT
ajst-31202	96	20	to	to	PART
ajst-31202	96	21	conduct	conduct	VERB
ajst-31202	96	22	multilayered	multilayered	ADJ
ajst-31202	96	23	analyses	analysis	NOUN
ajst-31202	96	24	[	[	X
ajst-31202	96	25	19	19	NUM
ajst-31202	96	26	]	]	PUNCT
ajst-31202	96	27	.	.	PUNCT
ajst-31202	97	1	these	these	DET
ajst-31202	97	2	advantages	advantage	NOUN
ajst-31202	97	3	enable	enable	VERB
ajst-31202	97	4	scrna	scrna	NOUN
ajst-31202	97	5	-	-	PUNCT
ajst-31202	97	6	seq	seq	NOUN
ajst-31202	97	7	to	to	PART
ajst-31202	97	8	be	be	AUX
ajst-31202	97	9	applied	apply	VERB
ajst-31202	97	10	in	in	ADP
ajst-31202	97	11	various	various	ADJ
ajst-31202	97	12	biological	biological	ADJ
ajst-31202	97	13	fields	field	NOUN
ajst-31202	97	14	,	,	PUNCT
ajst-31202	97	15	such	such	ADJ
ajst-31202	97	16	as	as	ADP
ajst-31202	97	17	large	large	ADJ
ajst-31202	97	18	-	-	PUNCT
ajst-31202	97	19	scale	scale	NOUN
ajst-31202	97	20	cell	cell	NOUN
ajst-31202	97	21	atlas	atlas	PROPN
ajst-31202	97	22	construction	construction	PROPN
ajst-31202	97	23	:	:	PUNCT
ajst-31202	97	24	by	by	ADP
ajst-31202	97	25	sequencing	sequence	VERB
ajst-31202	97	26	single	single	ADJ
ajst-31202	97	27	cells	cell	NOUN
ajst-31202	97	28	from	from	ADP
ajst-31202	97	29	specific	specific	ADJ
ajst-31202	97	30	tissues	tissue	NOUN
ajst-31202	97	31	or	or	CCONJ
ajst-31202	97	32	organs	organ	NOUN
ajst-31202	97	33	,	,	PUNCT
ajst-31202	97	34	it	it	PRON
ajst-31202	97	35	is	be	AUX
ajst-31202	97	36	possible	possible	ADJ
ajst-31202	97	37	to	to	PART
ajst-31202	97	38	obtain	obtain	VERB
ajst-31202	97	39	comprehensive	comprehensive	ADJ
ajst-31202	97	40	transcriptomic	transcriptomic	ADJ
ajst-31202	97	41	maps	map	NOUN
ajst-31202	97	42	,	,	PUNCT
ajst-31202	97	43	perform	perform	VERB
ajst-31202	97	44	cell	cell	NOUN
ajst-31202	97	45	type	type	NOUN
ajst-31202	97	46	clustering	clustering	NOUN
ajst-31202	97	47	and	and	CCONJ
ajst-31202	97	48	annotation	annotation	NOUN
ajst-31202	97	49	,	,	PUNCT
ajst-31202	97	50	and	and	CCONJ
ajst-31202	97	51	analyze	analyze	VERB
ajst-31202	97	52	the	the	DET
ajst-31202	97	53	functions	function	NOUN
ajst-31202	97	54	and	and	CCONJ
ajst-31202	97	55	interactions	interaction	NOUN
ajst-31202	97	56	of	of	ADP
ajst-31202	97	57	different	different	ADJ
ajst-31202	97	58	cell	cell	NOUN
ajst-31202	97	59	subtypes	subtype	NOUN
ajst-31202	97	60	,	,	PUNCT
ajst-31202	97	61	revealing	reveal	VERB
ajst-31202	97	62	the	the	DET
ajst-31202	97	63	structure	structure	NOUN
ajst-31202	97	64	and	and	CCONJ
ajst-31202	97	65	mechanisms	mechanism	NOUN
ajst-31202	97	66	of	of	ADP
ajst-31202	97	67	complex	complex	ADJ
ajst-31202	97	68	biological	biological	ADJ
ajst-31202	97	69	systems	system	NOUN
ajst-31202	97	70	.	.	PUNCT
ajst-31202	98	1	it	it	PRON
ajst-31202	98	2	is	be	AUX
ajst-31202	98	3	also	also	ADV
ajst-31202	98	4	useful	useful	ADJ
ajst-31202	98	5	in	in	ADP
ajst-31202	98	6	neuroscience	neuroscience	NOUN
ajst-31202	98	7	research	research	NOUN
ajst-31202	98	8	:	:	PUNCT
ajst-31202	98	9	by	by	ADP
ajst-31202	98	10	sequencing	sequence	VERB
ajst-31202	98	11	individual	individual	ADJ
ajst-31202	98	12	neurons	neuron	NOUN
ajst-31202	98	13	or	or	CCONJ
ajst-31202	98	14	neural	neural	ADJ
ajst-31202	98	15	stem	stem	NOUN
ajst-31202	98	16	cells	cell	NOUN
ajst-31202	98	17	in	in	ADP
ajst-31202	98	18	the	the	DET
ajst-31202	98	19	nervous	nervous	ADJ
ajst-31202	98	20	system	system	NOUN
ajst-31202	98	21	,	,	PUNCT
ajst-31202	98	22	it	it	PRON
ajst-31202	98	23	is	be	AUX
ajst-31202	98	24	possible	possible	ADJ
ajst-31202	98	25	to	to	PART
ajst-31202	98	26	obtain	obtain	VERB
ajst-31202	98	27	complex	complex	ADJ
ajst-31202	98	28	neuronal	neuronal	ADJ
ajst-31202	98	29	transcriptomic	transcriptomic	ADJ
ajst-31202	98	30	maps	map	NOUN
ajst-31202	98	31	,	,	PUNCT
ajst-31202	98	32	classify	classify	VERB
ajst-31202	98	33	neuronal	neuronal	ADJ
ajst-31202	98	34	subtypes	subtype	NOUN
ajst-31202	98	35	based	base	VERB
ajst-31202	98	36	on	on	ADP
ajst-31202	98	37	gene	gene	NOUN
ajst-31202	98	38	expression	expression	NOUN
ajst-31202	98	39	patterns	pattern	NOUN
ajst-31202	98	40	,	,	PUNCT
ajst-31202	98	41	understand	understand	VERB
ajst-31202	98	42	the	the	DET
ajst-31202	98	43	functions	function	NOUN
ajst-31202	98	44	and	and	CCONJ
ajst-31202	98	45	interconnections	interconnection	NOUN
ajst-31202	98	46	of	of	ADP
ajst-31202	98	47	different	different	ADJ
ajst-31202	98	48	neuron	neuron	NOUN
ajst-31202	98	49	types	type	NOUN
ajst-31202	98	50	,	,	PUNCT
ajst-31202	98	51	and	and	CCONJ
ajst-31202	98	52	explore	explore	VERB
ajst-31202	98	53	issues	issue	NOUN
ajst-31202	98	54	related	relate	VERB
ajst-31202	98	55	to	to	ADP
ajst-31202	98	56	neural	neural	ADJ
ajst-31202	98	57	system	system	NOUN
ajst-31202	98	58	development	development	NOUN
ajst-31202	98	59	,	,	PUNCT
ajst-31202	98	60	plasticity	plasticity	NOUN
ajst-31202	98	61	,	,	PUNCT
ajst-31202	98	62	and	and	CCONJ
ajst-31202	98	63	disease	disease	NOUN
ajst-31202	98	64	.	.	PUNCT
ajst-31202	99	1	additionally	additionally	ADV
ajst-31202	99	2	,	,	PUNCT
ajst-31202	99	3	this	this	DET
ajst-31202	99	4	technology	technology	NOUN
ajst-31202	99	5	can	can	AUX
ajst-31202	99	6	be	be	AUX
ajst-31202	99	7	applied	apply	VERB
ajst-31202	99	8	in	in	ADP
ajst-31202	99	9	developmental	developmental	ADJ
ajst-31202	99	10	biology	biology	NOUN
ajst-31202	99	11	,	,	PUNCT
ajst-31202	99	12	stem	stem	NOUN
ajst-31202	99	13	cell	cell	NOUN
ajst-31202	99	14	development	development	NOUN
ajst-31202	99	15	and	and	CCONJ
ajst-31202	99	16	differentiation	differentiation	NOUN
ajst-31202	99	17	studies	study	NOUN
ajst-31202	99	18	,	,	PUNCT
ajst-31202	99	19	and	and	CCONJ
ajst-31202	99	20	cancer	cancer	NOUN
ajst-31202	99	21	research	research	NOUN
ajst-31202	99	22	,	,	PUNCT
ajst-31202	99	23	among	among	ADP
ajst-31202	99	24	others	other	NOUN
ajst-31202	99	25	.	.	PUNCT
ajst-31202	100	1	4.2	4.2	NUM
ajst-31202	100	2	.	.	PUNCT
ajst-31202	100	3	strengths	strength	NOUN
ajst-31202	100	4	and	and	CCONJ
ajst-31202	100	5	applications	application	NOUN
ajst-31202	100	6	of	of	ADP
ajst-31202	100	7	st	st	PROPN
ajst-31202	100	8	technology	technology	PROPN
ajst-31202	100	9	the	the	DET
ajst-31202	100	10	primary	primary	ADJ
ajst-31202	100	11	advantage	advantage	NOUN
ajst-31202	100	12	of	of	ADP
ajst-31202	100	13	st	st	PROPN
ajst-31202	100	14	lies	lie	NOUN
ajst-31202	100	15	in	in	ADP
ajst-31202	100	16	its	its	PRON
ajst-31202	100	17	spatial	spatial	ADJ
ajst-31202	100	18	capabilities	capability	NOUN
ajst-31202	100	19	,	,	PUNCT
ajst-31202	100	20	such	such	ADJ
ajst-31202	100	21	as	as	ADP
ajst-31202	100	22	the	the	DET
ajst-31202	100	23	ability	ability	NOUN
ajst-31202	100	24	to	to	PART
ajst-31202	100	25	measure	measure	VERB
ajst-31202	100	26	the	the	DET
ajst-31202	100	27	expression	expression	NOUN
ajst-31202	100	28	of	of	ADP
ajst-31202	100	29	all	all	DET
ajst-31202	100	30	genes	gene	NOUN
ajst-31202	100	31	across	across	ADP
ajst-31202	100	32	complete	complete	ADJ
ajst-31202	100	33	tissue	tissue	NOUN
ajst-31202	100	34	sections	section	NOUN
ajst-31202	100	35	,	,	PUNCT
ajst-31202	100	36	rather	rather	ADV
ajst-31202	100	37	than	than	ADP
ajst-31202	100	38	being	be	AUX
ajst-31202	100	39	limited	limit	VERB
ajst-31202	100	40	to	to	ADP
ajst-31202	100	41	a	a	DET
ajst-31202	100	42	small	small	ADJ
ajst-31202	100	43	number	number	NOUN
ajst-31202	100	44	of	of	ADP
ajst-31202	100	45	pre	pre	ADJ
ajst-31202	100	46	-	-	ADJ
ajst-31202	100	47	selected	select	VERB
ajst-31202	100	48	genes	gene	NOUN
ajst-31202	100	49	.	.	PUNCT
ajst-31202	101	1	it	it	PRON
ajst-31202	101	2	can	can	AUX
ajst-31202	101	3	also	also	ADV
ajst-31202	101	4	analyze	analyze	VERB
ajst-31202	101	5	different	different	ADJ
ajst-31202	101	6	tissue	tissue	NOUN
ajst-31202	101	7	types	type	NOUN
ajst-31202	101	8	and	and	CCONJ
ajst-31202	101	9	sample	sample	NOUN
ajst-31202	101	10	conditions	condition	NOUN
ajst-31202	101	11	,	,	PUNCT
ajst-31202	101	12	including	include	VERB
ajst-31202	101	13	fresh	fresh	ADJ
ajst-31202	101	14	frozen	frozen	ADJ
ajst-31202	101	15	samples	sample	NOUN
ajst-31202	101	16	and	and	CCONJ
ajst-31202	101	17	fixed	fix	VERB
ajst-31202	101	18	samples	sample	NOUN
ajst-31202	101	19	.	.	PUNCT
ajst-31202	102	1	most	most	ADV
ajst-31202	102	2	importantly	importantly	ADV
ajst-31202	102	3	,	,	PUNCT
ajst-31202	102	4	it	it	PRON
ajst-31202	102	5	retains	retain	VERB
ajst-31202	102	6	the	the	DET
ajst-31202	102	7	spatial	spatial	ADJ
ajst-31202	102	8	information	information	NOUN
ajst-31202	102	9	of	of	ADP
ajst-31202	102	10	cells	cell	NOUN
ajst-31202	102	11	in	in	ADP
ajst-31202	102	12	their	their	PRON
ajst-31202	102	13	original	original	ADJ
ajst-31202	102	14	location	location	NOUN
ajst-31202	102	15	,	,	PUNCT
ajst-31202	102	16	rather	rather	ADV
ajst-31202	102	17	than	than	ADP
ajst-31202	102	18	isolating	isolate	VERB
ajst-31202	102	19	or	or	CCONJ
ajst-31202	102	20	disrupting	disrupt	VERB
ajst-31202	102	21	cells	cell	NOUN
ajst-31202	102	22	before	before	ADP
ajst-31202	102	23	sequencing	sequence	VERB
ajst-31202	102	24	.	.	PUNCT
ajst-31202	103	1	st	st	PROPN
ajst-31202	103	2	is	be	AUX
ajst-31202	103	3	mainly	mainly	ADV
ajst-31202	103	4	used	use	VERB
ajst-31202	103	5	to	to	PART
ajst-31202	103	6	study	study	VERB
ajst-31202	103	7	the	the	DET
ajst-31202	103	8	spatiotemporal	spatiotemporal	ADJ
ajst-31202	103	9	dynamics	dynamic	NOUN
ajst-31202	103	10	of	of	ADP
ajst-31202	103	11	gene	gene	NOUN
ajst-31202	103	12	expression	expression	NOUN
ajst-31202	103	13	in	in	ADP
ajst-31202	103	14	multicellular	multicellular	ADJ
ajst-31202	103	15	organisms	organism	NOUN
ajst-31202	103	16	[	[	X
ajst-31202	103	17	20	20	NUM
ajst-31202	103	18	]	]	PUNCT
ajst-31202	103	19	,	,	PUNCT
ajst-31202	103	20	revealing	reveal	VERB
ajst-31202	103	21	molecular	molecular	ADJ
ajst-31202	103	22	mechanisms	mechanism	NOUN
ajst-31202	103	23	involved	involve	VERB
ajst-31202	103	24	in	in	ADP
ajst-31202	103	25	processes	process	NOUN
ajst-31202	103	26	such	such	ADJ
ajst-31202	103	27	as	as	ADP
ajst-31202	103	28	development	development	NOUN
ajst-31202	103	29	,	,	PUNCT
ajst-31202	103	30	differentiation	differentiation	NOUN
ajst-31202	103	31	,	,	PUNCT
ajst-31202	103	32	and	and	CCONJ
ajst-31202	103	33	signaling	signal	VERB
ajst-31202	103	34	,	,	PUNCT
ajst-31202	103	35	as	as	ADV
ajst-31202	103	36	well	well	ADV
ajst-31202	103	37	as	as	ADP
ajst-31202	103	38	the	the	DET
ajst-31202	103	39	interactions	interaction	NOUN
ajst-31202	103	40	between	between	ADP
ajst-31202	103	41	neurons	neuron	NOUN
ajst-31202	103	42	and	and	CCONJ
ajst-31202	103	43	glial	glial	ADJ
ajst-31202	103	44	cells	cell	NOUN
ajst-31202	103	45	in	in	ADP
ajst-31202	103	46	the	the	DET
ajst-31202	103	47	nervous	nervous	ADJ
ajst-31202	103	48	system	system	NOUN
ajst-31202	103	49	.	.	PUNCT
ajst-31202	104	1	it	it	PRON
ajst-31202	104	2	can	can	AUX
ajst-31202	104	3	also	also	ADV
ajst-31202	104	4	be	be	AUX
ajst-31202	104	5	used	use	VERB
ajst-31202	104	6	to	to	PART
ajst-31202	104	7	explore	explore	VERB
ajst-31202	104	8	potential	potential	ADJ
ajst-31202	104	9	molecular	molecular	ADJ
ajst-31202	104	10	mechanisms	mechanism	NOUN
ajst-31202	104	11	underlying	underlie	VERB
ajst-31202	104	12	neurodegenerative	neurodegenerative	ADJ
ajst-31202	104	13	diseases	disease	NOUN
ajst-31202	104	14	and	and	CCONJ
ajst-31202	104	15	other	other	ADJ
ajst-31202	104	16	neurological	neurological	ADJ
ajst-31202	104	17	disorders	disorder	NOUN
ajst-31202	104	18	.	.	PUNCT
ajst-31202	105	1	4.3	4.3	NUM
ajst-31202	105	2	.	.	PUNCT
ajst-31202	105	3	synergy	synergy	NOUN
ajst-31202	105	4	between	between	ADP
ajst-31202	105	5	scrna	scrna	NOUN
ajst-31202	105	6	-	-	PUNCT
ajst-31202	105	7	seq	seq	NOUN
ajst-31202	105	8	and	and	CCONJ
ajst-31202	105	9	st	st	X
ajst-31202	105	10	the	the	DET
ajst-31202	105	11	advantage	advantage	NOUN
ajst-31202	105	12	of	of	ADP
ajst-31202	105	13	scrna	scrna	NOUN
ajst-31202	105	14	-	-	PUNCT
ajst-31202	105	15	seq	seq	NOUN
ajst-31202	105	16	is	be	AUX
ajst-31202	105	17	its	its	PRON
ajst-31202	105	18	ability	ability	NOUN
ajst-31202	105	19	to	to	PART
ajst-31202	105	20	analyze	analyze	VERB
ajst-31202	105	21	both	both	CCONJ
ajst-31202	105	22	intracellular	intracellular	ADJ
ajst-31202	105	23	and	and	CCONJ
ajst-31202	105	24	intercellular	intercellular	ADJ
ajst-31202	105	25	heterogeneity	heterogeneity	NOUN
ajst-31202	105	26	,	,	PUNCT
ajst-31202	105	27	identify	identify	VERB
ajst-31202	105	28	new	new	ADJ
ajst-31202	105	29	cell	cell	NOUN
ajst-31202	105	30	types	type	NOUN
ajst-31202	105	31	and	and	CCONJ
ajst-31202	105	32	states	state	NOUN
ajst-31202	105	33	,	,	PUNCT
ajst-31202	105	34	explore	explore	VERB
ajst-31202	105	35	the	the	DET
ajst-31202	105	36	trajectories	trajectory	NOUN
ajst-31202	105	37	of	of	ADP
ajst-31202	105	38	cell	cell	NOUN
ajst-31202	105	39	development	development	NOUN
ajst-31202	105	40	and	and	CCONJ
ajst-31202	105	41	differentiation	differentiation	NOUN
ajst-31202	105	42	,	,	PUNCT
ajst-31202	105	43	and	and	CCONJ
ajst-31202	105	44	understand	understand	VERB
ajst-31202	105	45	transcriptional	transcriptional	ADJ
ajst-31202	105	46	dynamics	dynamic	NOUN
ajst-31202	105	47	and	and	CCONJ
ajst-31202	105	48	gene	gene	NOUN
ajst-31202	105	49	regulatory	regulatory	ADJ
ajst-31202	105	50	relationships	relationship	NOUN
ajst-31202	105	51	.	.	PUNCT
ajst-31202	106	1	on	on	ADP
ajst-31202	106	2	the	the	DET
ajst-31202	106	3	other	other	ADJ
ajst-31202	106	4	hand	hand	NOUN
ajst-31202	106	5	,	,	PUNCT
ajst-31202	106	6	st	st	PROPN
ajst-31202	106	7	combines	combine	VERB
ajst-31202	106	8	gene	gene	NOUN
ajst-31202	106	9	expression	expression	NOUN
ajst-31202	106	10	data	datum	NOUN
ajst-31202	106	11	with	with	ADP
ajst-31202	106	12	the	the	DET
ajst-31202	106	13	morphological	morphological	ADJ
ajst-31202	106	14	features	feature	NOUN
ajst-31202	106	15	of	of	ADP
ajst-31202	106	16	tissue	tissue	NOUN
ajst-31202	106	17	sections	section	NOUN
ajst-31202	106	18	,	,	PUNCT
ajst-31202	106	19	revealing	reveal	VERB
ajst-31202	106	20	the	the	DET
ajst-31202	106	21	heterogeneity	heterogeneity	NOUN
ajst-31202	106	22	and	and	CCONJ
ajst-31202	106	23	functions	function	NOUN
ajst-31202	106	24	of	of	ADP
ajst-31202	106	25	cells	cell	NOUN
ajst-31202	106	26	in	in	ADP
ajst-31202	106	27	the	the	DET
ajst-31202	106	28	spatial	spatial	ADJ
ajst-31202	106	29	dimension	dimension	NOUN
ajst-31202	106	30	.	.	PUNCT
ajst-31202	107	1	in	in	ADP
ajst-31202	107	2	the	the	DET
ajst-31202	107	3	research	research	NOUN
ajst-31202	107	4	process	process	NOUN
ajst-31202	107	5	,	,	PUNCT
ajst-31202	107	6	we	we	PRON
ajst-31202	107	7	can	can	AUX
ajst-31202	107	8	leverage	leverage	VERB
ajst-31202	107	9	the	the	DET
ajst-31202	107	10	complementary	complementary	ADJ
ajst-31202	107	11	strengths	strength	NOUN
ajst-31202	107	12	of	of	ADP
ajst-31202	107	13	both	both	DET
ajst-31202	107	14	technologies	technology	NOUN
ajst-31202	107	15	to	to	PART
ajst-31202	107	16	achieve	achieve	VERB
ajst-31202	107	17	enhanced	enhanced	ADJ
ajst-31202	107	18	transcriptional	transcriptional	ADJ
ajst-31202	107	19	insights	insight	NOUN
ajst-31202	107	20	.	.	PUNCT
ajst-31202	108	1	acknowledgment	acknowledgment	NOUN
ajst-31202	108	2	the	the	DET
ajst-31202	108	3	author	author	NOUN
ajst-31202	108	4	is	be	AUX
ajst-31202	108	5	grateful	grateful	ADJ
ajst-31202	108	6	to	to	ADP
ajst-31202	108	7	the	the	DET
ajst-31202	108	8	reviewers	reviewer	NOUN
ajst-31202	108	9	for	for	ADP
ajst-31202	108	10	their	their	PRON
ajst-31202	108	11	critical	critical	ADJ
ajst-31202	108	12	comments	comment	NOUN
ajst-31202	108	13	and	and	CCONJ
ajst-31202	108	14	numerous	numerous	ADJ
ajst-31202	108	15	suggestions	suggestion	NOUN
ajst-31202	108	16	.	.	PUNCT
ajst-31202	109	1	references	reference	NOUN
ajst-31202	109	2	[	[	X
ajst-31202	109	3	1	1	X
ajst-31202	109	4	]	]	PUNCT
ajst-31202	109	5	macosko	macosko	NOUN
ajst-31202	109	6	e	e	PROPN
ajst-31202	109	7	z	z	PROPN
ajst-31202	109	8	,	,	PUNCT
ajst-31202	109	9	basu	basu	PROPN
ajst-31202	109	10	a	a	X
ajst-31202	109	11	,	,	PUNCT
ajst-31202	109	12	satija	satija	ADJ
ajst-31202	109	13	r	r	NOUN
ajst-31202	109	14	,	,	PUNCT
ajst-31202	109	15	et	et	PROPN
ajst-31202	109	16	al	al	PROPN
ajst-31202	109	17	.	.	PUNCT
ajst-31202	110	1	highly	highly	ADV
ajst-31202	110	2	parallel	parallel	ADJ
ajst-31202	110	3	genome	genome	NOUN
ajst-31202	110	4	-	-	PUNCT
ajst-31202	110	5	wide	wide	ADJ
ajst-31202	110	6	expression	expression	NOUN
ajst-31202	110	7	profiling	profiling	NOUN
ajst-31202	110	8	of	of	ADP
ajst-31202	110	9	individual	individual	ADJ
ajst-31202	110	10	cells	cell	NOUN
ajst-31202	110	11	using	use	VERB
ajst-31202	110	12	nanoliter	nanoliter	ADJ
ajst-31202	110	13	droplets[j	droplets[j	NOUN
ajst-31202	110	14	]	]	PUNCT
ajst-31202	110	15	.	.	PUNCT
ajst-31202	111	1	cell	cell	NOUN
ajst-31202	111	2	,	,	PUNCT
ajst-31202	111	3	2015	2015	NUM
ajst-31202	111	4	,	,	PUNCT
ajst-31202	111	5	161(5	161(5	NUM
ajst-31202	111	6	):	):	PUNCT
ajst-31202	111	7	1202–1214	1202–1214	NUM
ajst-31202	111	8	.	.	PUNCT
ajst-31202	112	1	doi	doi	NOUN
ajst-31202	112	2	:	:	PUNCT
ajst-31202	112	3	10.1016	10.1016	NUM
ajst-31202	112	4	/	/	SYM
ajst-31202	112	5	j.cell.2015.05.002	j.cell.2015.05.002	PROPN
ajst-31202	112	6	.	.	PUNCT
ajst-31202	113	1	[	[	X
ajst-31202	113	2	2	2	NUM
ajst-31202	113	3	]	]	PUNCT
ajst-31202	113	4	tang	tang	X
ajst-31202	113	5	f	f	NOUN
ajst-31202	113	6	,	,	PUNCT
ajst-31202	113	7	barbacioru	barbacioru	NOUN
ajst-31202	113	8	c	c	PROPN
ajst-31202	113	9	,	,	PUNCT
ajst-31202	113	10	wang	wang	PROPN
ajst-31202	113	11	y	y	PROPN
ajst-31202	113	12	,	,	PUNCT
ajst-31202	113	13	et	et	PROPN
ajst-31202	113	14	al	al	PROPN
ajst-31202	113	15	.	.	PUNCT
ajst-31202	113	16	mrna	mrna	PROPN
ajst-31202	113	17	-	-	PUNCT
ajst-31202	113	18	seq	seq	NOUN
ajst-31202	113	19	whole	whole	ADJ
ajst-31202	113	20	-	-	PUNCT
ajst-31202	113	21	transcriptome	transcriptome	NOUN
ajst-31202	113	22	analysis	analysis	NOUN
ajst-31202	113	23	of	of	ADP
ajst-31202	113	24	a	a	DET
ajst-31202	113	25	single	single	ADJ
ajst-31202	113	26	cell[j	cell[j	PROPN
ajst-31202	113	27	]	]	PUNCT
ajst-31202	113	28	.	.	PUNCT
ajst-31202	114	1	nature	nature	NOUN
ajst-31202	114	2	methods	method	NOUN
ajst-31202	114	3	,	,	PUNCT
ajst-31202	114	4	2009	2009	NUM
ajst-31202	114	5	,	,	PUNCT
ajst-31202	114	6	6(5	6(5	NUM
ajst-31202	114	7	):	):	PUNCT
ajst-31202	114	8	377–382	377–382	NUM
ajst-31202	114	9	.	.	PUNCT
ajst-31202	115	1	doi	doi	NOUN
ajst-31202	115	2	:	:	PUNCT
ajst-31202	115	3	10.1038	10.1038	NUM
ajst-31202	115	4	/	/	SYM
ajst-31202	115	5	nmeth.1315	nmeth.1315	PROPN
ajst-31202	115	6	.	.	PUNCT
ajst-31202	116	1	[	[	X
ajst-31202	116	2	3	3	X
ajst-31202	116	3	]	]	X
ajst-31202	116	4	ståhl	ståhl	NOUN
ajst-31202	116	5	p	p	PROPN
ajst-31202	116	6	l	l	NOUN
ajst-31202	116	7	,	,	PUNCT
ajst-31202	116	8	salmén	salmén	ADJ
ajst-31202	116	9	f	f	NOUN
ajst-31202	116	10	,	,	PUNCT
ajst-31202	116	11	vickovic	vickovic	PROPN
ajst-31202	116	12	s	s	PROPN
ajst-31202	116	13	,	,	PUNCT
ajst-31202	116	14	et	et	PROPN
ajst-31202	116	15	al	al	PROPN
ajst-31202	116	16	.	.	PUNCT
ajst-31202	116	17	visualization	visualization	NOUN
ajst-31202	116	18	and	and	CCONJ
ajst-31202	116	19	analysis	analysis	NOUN
ajst-31202	116	20	of	of	ADP
ajst-31202	116	21	gene	gene	NOUN
ajst-31202	116	22	expression	expression	NOUN
ajst-31202	116	23	in	in	ADP
ajst-31202	116	24	tissue	tissue	NOUN
ajst-31202	116	25	sections	section	NOUN
ajst-31202	116	26	by	by	ADP
ajst-31202	116	27	spatial	spatial	ADJ
ajst-31202	116	28	transcriptomics[j	transcriptomics[j	PROPN
ajst-31202	116	29	]	]	PUNCT
ajst-31202	116	30	.	.	PUNCT
ajst-31202	117	1	science	science	NOUN
ajst-31202	117	2	,	,	PUNCT
ajst-31202	117	3	2016	2016	NUM
ajst-31202	117	4	,	,	PUNCT
ajst-31202	117	5	353(6294	353(6294	NUM
ajst-31202	117	6	):	):	PUNCT
ajst-31202	117	7	78–82	78–82	NUM
ajst-31202	117	8	.	.	PUNCT
ajst-31202	117	9	doi	doi	NOUN
ajst-31202	117	10	:	:	PUNCT
ajst-31202	117	11	10.1126	10.1126	NUM
ajst-31202	117	12	/	/	SYM
ajst-31202	117	13	science.aaf2403	science.aaf2403	PROPN
ajst-31202	117	14	.	.	PUNCT
ajst-31202	118	1	[	[	X
ajst-31202	118	2	4	4	NUM
ajst-31202	118	3	]	]	X
ajst-31202	118	4	qian	qian	PROPN
ajst-31202	118	5	x	x	SYM
ajst-31202	118	6	,	,	PUNCT
ajst-31202	118	7	yu	yu	PROPN
ajst-31202	118	8	w	w	PROPN
ajst-31202	118	9	,	,	PUNCT
ajst-31202	118	10	chen	chen	PROPN
ajst-31202	118	11	h	h	PROPN
ajst-31202	118	12	,	,	PUNCT
ajst-31202	118	13	et	et	PROPN
ajst-31202	118	14	al	al	PROPN
ajst-31202	118	15	.	.	PROPN
ajst-31202	118	16	probabilistic	probabilistic	ADJ
ajst-31202	118	17	cell	cell	NOUN
ajst-31202	118	18	typing	typing	NOUN
ajst-31202	118	19	enables	enable	VERB
ajst-31202	118	20	fine	fine	ADJ
ajst-31202	118	21	mapping	mapping	NOUN
ajst-31202	118	22	of	of	ADP
ajst-31202	118	23	closely	closely	ADV
ajst-31202	118	24	related	relate	VERB
ajst-31202	118	25	cell	cell	NOUN
ajst-31202	118	26	types	type	NOUN
ajst-31202	118	27	in	in	ADP
ajst-31202	118	28	situ[j	situ[j	NOUN
ajst-31202	118	29	]	]	PUNCT
ajst-31202	118	30	.	.	PUNCT
ajst-31202	119	1	nature	nature	NOUN
ajst-31202	119	2	methods	method	NOUN
ajst-31202	119	3	,	,	PUNCT
ajst-31202	119	4	2020	2020	NUM
ajst-31202	119	5	,	,	PUNCT
ajst-31202	119	6	17(1	17(1	NUM
ajst-31202	119	7	):	):	PUNCT
ajst-31202	119	8	101–106	101–106	NUM
ajst-31202	119	9	.	.	PUNCT
ajst-31202	120	1	doi	doi	NOUN
ajst-31202	120	2	:	:	PUNCT
ajst-31202	120	3	10.1038	10.1038	NUM
ajst-31202	120	4	/	/	SYM
ajst-31202	120	5	s41592019	s41592019	PROPN
ajst-31202	120	6	-	-	PUNCT
ajst-31202	120	7	0699	0699	NUM
ajst-31202	120	8	-	-	PUNCT
ajst-31202	120	9	4	4	NUM
ajst-31202	120	10	.	.	PUNCT
ajst-31202	121	1	[	[	X
ajst-31202	121	2	5	5	X
ajst-31202	121	3	]	]	X
ajst-31202	121	4	bergen	bergen	PROPN
ajst-31202	121	5	v	v	PROPN
ajst-31202	121	6	,	,	PUNCT
ajst-31202	121	7	lange	lange	PROPN
ajst-31202	121	8	m	m	PROPN
ajst-31202	121	9	,	,	PUNCT
ajst-31202	121	10	peidli	peidli	PROPN
ajst-31202	121	11	s	s	PROPN
ajst-31202	121	12	,	,	PUNCT
ajst-31202	121	13	et	et	PROPN
ajst-31202	121	14	al	al	PROPN
ajst-31202	121	15	.	.	PUNCT
ajst-31202	121	16	generalizing	generalize	VERB
ajst-31202	121	17	rna	rna	NOUN
ajst-31202	121	18	velocity	velocity	NOUN
ajst-31202	121	19	to	to	PART
ajst-31202	121	20	transient	transient	VERB
ajst-31202	121	21	cell	cell	NOUN
ajst-31202	121	22	states	state	NOUN
ajst-31202	121	23	through	through	ADP
ajst-31202	121	24	dynamical	dynamical	ADJ
ajst-31202	121	25	modeling[j	modeling[j	NOUN
ajst-31202	121	26	]	]	PUNCT
ajst-31202	121	27	.	.	PUNCT
ajst-31202	122	1	nature	nature	NOUN
ajst-31202	122	2	biotechnology	biotechnology	NOUN
ajst-31202	122	3	,	,	PUNCT
ajst-31202	122	4	2020	2020	NUM
ajst-31202	122	5	,	,	PUNCT
ajst-31202	122	6	38(12	38(12	NUM
ajst-31202	122	7	):	):	PUNCT
ajst-31202	122	8	1408–1414	1408–1414	NUM
ajst-31202	122	9	.	.	PUNCT
ajst-31202	123	1	doi	doi	NOUN
ajst-31202	123	2	:	:	PUNCT
ajst-31202	123	3	10.1038	10.1038	NUM
ajst-31202	123	4	/	/	SYM
ajst-31202	123	5	s41587	s41587	PROPN
ajst-31202	123	6	-	-	PUNCT
ajst-31202	123	7	020	020	NUM
ajst-31202	123	8	-	-	PUNCT
ajst-31202	123	9	0591	0591	NUM
ajst-31202	123	10	-	-	PUNCT
ajst-31202	123	11	3	3	NUM
ajst-31202	123	12	.	.	PUNCT
ajst-31202	124	1	[	[	X
ajst-31202	124	2	6	6	NUM
ajst-31202	124	3	]	]	PUNCT
ajst-31202	124	4	keren	keren	PROPN
ajst-31202	124	5	l	l	PROPN
ajst-31202	124	6	,	,	PUNCT
ajst-31202	124	7	bosse	bosse	PROPN
ajst-31202	124	8	m	m	PROPN
ajst-31202	124	9	,	,	PUNCT
ajst-31202	124	10	marquez	marquez	PROPN
ajst-31202	124	11	d	d	PROPN
ajst-31202	124	12	,	,	PUNCT
ajst-31202	124	13	et	et	PROPN
ajst-31202	124	14	al	al	PROPN
ajst-31202	124	15	.	.	PUNCT
ajst-31202	125	1	a	a	DET
ajst-31202	125	2	structured	structured	ADJ
ajst-31202	125	3	tumor	tumor	NOUN
ajst-31202	125	4	-	-	PUNCT
ajst-31202	125	5	immune	immune	ADJ
ajst-31202	125	6	microenvironment	microenvironment	NOUN
ajst-31202	125	7	in	in	ADP
ajst-31202	125	8	triple	triple	ADJ
ajst-31202	125	9	negative	negative	ADJ
ajst-31202	125	10	breast	breast	NOUN
ajst-31202	125	11	cancer	cancer	NOUN
ajst-31202	125	12	revealed	reveal	VERB
ajst-31202	125	13	by	by	ADP
ajst-31202	125	14	multiplexed	multiplexed	ADJ
ajst-31202	125	15	ion	ion	NOUN
ajst-31202	125	16	beam	beam	NOUN
ajst-31202	125	17	imaging[j	imaging[j	PROPN
ajst-31202	125	18	]	]	PUNCT
ajst-31202	125	19	.	.	PUNCT
ajst-31202	126	1	cell	cell	NOUN
ajst-31202	126	2	,	,	PUNCT
ajst-31202	126	3	2018	2018	NUM
ajst-31202	126	4	,	,	PUNCT
ajst-31202	126	5	174(6	174(6	NUM
ajst-31202	126	6	):	):	PUNCT
ajst-31202	126	7	1373–1387	1373–1387	NUM
ajst-31202	126	8	.	.	PUNCT
ajst-31202	127	1	doi	doi	NOUN
ajst-31202	127	2	:	:	PUNCT
ajst-31202	127	3	10.1016	10.1016	NUM
ajst-31202	127	4	/	/	SYM
ajst-31202	127	5	j.cell.2018.08.039	j.cell.2018.08.039	PROPN
ajst-31202	127	6	.	.	PUNCT
ajst-31202	128	1	[	[	X
ajst-31202	128	2	7	7	X
ajst-31202	128	3	]	]	X
ajst-31202	128	4	moncada	moncada	NOUN
ajst-31202	128	5	r	r	NOUN
ajst-31202	128	6	,	,	PUNCT
ajst-31202	128	7	barkley	barkley	PROPN
ajst-31202	128	8	d	d	PROPN
ajst-31202	128	9	,	,	PUNCT
ajst-31202	128	10	wagner	wagner	PROPN
ajst-31202	128	11	f	f	PROPN
ajst-31202	128	12	,	,	PUNCT
ajst-31202	128	13	et	et	PROPN
ajst-31202	128	14	al	al	PROPN
ajst-31202	128	15	.	.	PUNCT
ajst-31202	128	16	integrating	integrate	VERB
ajst-31202	128	17	microarray	microarray	NOUN
ajst-31202	128	18	-	-	PUNCT
ajst-31202	128	19	based	base	VERB
ajst-31202	128	20	spatial	spatial	ADJ
ajst-31202	128	21	transcriptomics	transcriptomic	NOUN
ajst-31202	128	22	and	and	CCONJ
ajst-31202	128	23	single	single	ADJ
ajst-31202	128	24	-	-	PUNCT
ajst-31202	128	25	cell	cell	NOUN
ajst-31202	128	26	rna	rna	NOUN
ajst-31202	128	27	-	-	PUNCT
ajst-31202	128	28	seq	seq	NOUN
ajst-31202	128	29	reveals	reveal	VERB
ajst-31202	128	30	tissue	tissue	NOUN
ajst-31202	128	31	architecture	architecture	NOUN
ajst-31202	128	32	in	in	ADP
ajst-31202	128	33	pancreatic	pancreatic	ADJ
ajst-31202	128	34	ductal	ductal	ADJ
ajst-31202	128	35	adenocarcinomas[j	adenocarcinomas[j	NOUN
ajst-31202	128	36	]	]	PUNCT
ajst-31202	128	37	.	.	PUNCT
ajst-31202	129	1	nature	nature	NOUN
ajst-31202	129	2	biotechnology	biotechnology	NOUN
ajst-31202	129	3	,	,	PUNCT
ajst-31202	129	4	2020	2020	NUM
ajst-31202	129	5	,	,	PUNCT
ajst-31202	129	6	38(3	38(3	NUM
ajst-31202	129	7	):	):	PUNCT
ajst-31202	129	8	333	333	NUM
ajst-31202	129	9	–	–	PUNCT
ajst-31202	129	10	342	342	NUM
ajst-31202	129	11	.	.	PUNCT
ajst-31202	130	1	doi	doi	NOUN
ajst-31202	130	2	:	:	PUNCT
ajst-31202	130	3	10.1038	10.1038	NUM
ajst-31202	130	4	/	/	SYM
ajst-31202	130	5	s41587	s41587	PROPN
ajst-31202	130	6	-	-	PUNCT
ajst-31202	130	7	019	019	NUM
ajst-31202	130	8	-	-	PUNCT
ajst-31202	130	9	0392	0392	NUM
ajst-31202	130	10	-	-	SYM
ajst-31202	130	11	8	8	NUM
ajst-31202	130	12	.	.	PUNCT
ajst-31202	131	1	[	[	X
ajst-31202	131	2	8	8	X
ajst-31202	131	3	]	]	X
ajst-31202	131	4	klein	klein	PROPN
ajst-31202	131	5	a	a	PROPN
ajst-31202	131	6	m	m	PROPN
ajst-31202	131	7	,	,	PUNCT
ajst-31202	131	8	mazutis	mazutis	PROPN
ajst-31202	131	9	l	l	NOUN
ajst-31202	131	10	,	,	PUNCT
ajst-31202	131	11	akartuna	akartuna	VERB
ajst-31202	131	12	i	i	PRON
ajst-31202	131	13	,	,	PUNCT
ajst-31202	131	14	et	et	PROPN
ajst-31202	131	15	al	al	PROPN
ajst-31202	131	16	.	.	PROPN
ajst-31202	132	1	droplet	droplet	ADJ
ajst-31202	132	2	barcoding	barcoding	NOUN
ajst-31202	132	3	for	for	ADP
ajst-31202	132	4	single	single	ADJ
ajst-31202	132	5	-	-	PUNCT
ajst-31202	132	6	cell	cell	NOUN
ajst-31202	132	7	transcriptomics	transcriptomic	NOUN
ajst-31202	132	8	applied	apply	VERB
ajst-31202	132	9	to	to	PART
ajst-31202	132	10	embryonic	embryonic	VERB
ajst-31202	132	11	stem	stem	NOUN
ajst-31202	132	12	cells[j	cells[j	NOUN
ajst-31202	132	13	]	]	PUNCT
ajst-31202	132	14	.	.	PUNCT
ajst-31202	133	1	cell	cell	NOUN
ajst-31202	133	2	,	,	PUNCT
ajst-31202	133	3	2015	2015	NUM
ajst-31202	133	4	,	,	PUNCT
ajst-31202	133	5	161(5	161(5	NUM
ajst-31202	133	6	):	):	PUNCT
ajst-31202	133	7	1187–1201	1187–1201	NUM
ajst-31202	133	8	.	.	PUNCT
ajst-31202	134	1	doi	doi	NOUN
ajst-31202	134	2	:	:	PUNCT
ajst-31202	134	3	10.1016	10.1016	NUM
ajst-31202	134	4	/	/	SYM
ajst-31202	134	5	j.cell.2015.04.044	j.cell.2015.04.044	PROPN
ajst-31202	134	6	.	.	PROPN
ajst-31202	135	1	54	54	NUM
ajst-31202	136	1	[	[	SYM
ajst-31202	136	2	9	9	NUM
ajst-31202	136	3	]	]	X
ajst-31202	136	4	sheng	sheng	PROPN
ajst-31202	136	5	k	k	PROPN
ajst-31202	136	6	,	,	PUNCT
ajst-31202	136	7	cao	cao	PROPN
ajst-31202	136	8	w	w	PROPN
ajst-31202	136	9	,	,	PUNCT
ajst-31202	136	10	niu	niu	PROPN
ajst-31202	136	11	y	y	PROPN
ajst-31202	136	12	,	,	PUNCT
ajst-31202	136	13	et	et	PROPN
ajst-31202	136	14	al	al	PROPN
ajst-31202	136	15	.	.	PROPN
ajst-31202	136	16	effective	effective	ADJ
ajst-31202	136	17	detection	detection	NOUN
ajst-31202	136	18	of	of	ADP
ajst-31202	136	19	variation	variation	NOUN
ajst-31202	136	20	in	in	ADP
ajst-31202	136	21	single	single	ADJ
ajst-31202	136	22	-	-	PUNCT
ajst-31202	136	23	cell	cell	NOUN
ajst-31202	136	24	transcriptomes	transcriptome	NOUN
ajst-31202	136	25	using	use	VERB
ajst-31202	136	26	matq	matq	NOUN
ajst-31202	136	27	-	-	PUNCT
ajst-31202	136	28	seq[j	seq[j	NOUN
ajst-31202	136	29	]	]	PUNCT
ajst-31202	136	30	.	.	PUNCT
ajst-31202	137	1	nature	nature	NOUN
ajst-31202	137	2	methods	method	NOUN
ajst-31202	137	3	,	,	PUNCT
ajst-31202	137	4	2017	2017	NUM
ajst-31202	137	5	,	,	PUNCT
ajst-31202	137	6	14(3	14(3	NUM
ajst-31202	137	7	):	):	PUNCT
ajst-31202	137	8	267–270	267–270	NUM
ajst-31202	137	9	.	.	PUNCT
ajst-31202	138	1	doi	doi	NOUN
ajst-31202	138	2	:	:	PUNCT
ajst-31202	138	3	10.1038	10.1038	NUM
ajst-31202	138	4	/	/	SYM
ajst-31202	138	5	nmeth.4145	nmeth.4145	PROPN
ajst-31202	138	6	.	.	PUNCT
ajst-31202	139	1	[	[	X
ajst-31202	139	2	10	10	NUM
ajst-31202	139	3	]	]	X
ajst-31202	139	4	gierahn	gierahn	PROPN
ajst-31202	139	5	t	t	PROPN
ajst-31202	139	6	m	m	PROPN
ajst-31202	139	7	,	,	PUNCT
ajst-31202	139	8	wadsworth	wadsworth	PROPN
ajst-31202	139	9	m	m	PROPN
ajst-31202	139	10	h	h	PROPN
ajst-31202	139	11	,	,	PUNCT
ajst-31202	139	12	hughes	hughes	PROPN
ajst-31202	139	13	t	t	PROPN
ajst-31202	139	14	k	k	PROPN
ajst-31202	139	15	,	,	PUNCT
ajst-31202	139	16	et	et	PROPN
ajst-31202	139	17	al	al	PROPN
ajst-31202	139	18	.	.	PROPN
ajst-31202	139	19	seq	seq	PROPN
ajst-31202	139	20	-	-	PUNCT
ajst-31202	139	21	well	well	NOUN
ajst-31202	139	22	:	:	PUNCT
ajst-31202	139	23	portable	portable	ADJ
ajst-31202	139	24	,	,	PUNCT
ajst-31202	139	25	low	low	ADJ
ajst-31202	139	26	-	-	PUNCT
ajst-31202	139	27	cost	cost	NOUN
ajst-31202	139	28	rna	rna	NOUN
ajst-31202	139	29	sequencing	sequencing	NOUN
ajst-31202	139	30	of	of	ADP
ajst-31202	139	31	single	single	ADJ
ajst-31202	139	32	cells	cell	NOUN
ajst-31202	139	33	at	at	ADP
ajst-31202	139	34	high	high	ADJ
ajst-31202	139	35	throughput[j	throughput[j	PROPN
ajst-31202	139	36	]	]	PUNCT
ajst-31202	139	37	.	.	PUNCT
ajst-31202	140	1	nature	nature	NOUN
ajst-31202	140	2	methods	method	NOUN
ajst-31202	140	3	,	,	PUNCT
ajst-31202	140	4	2017	2017	NUM
ajst-31202	140	5	,	,	PUNCT
ajst-31202	140	6	14(4	14(4	NUM
ajst-31202	140	7	):	):	PUNCT
ajst-31202	140	8	395–398	395–398	NUM
ajst-31202	140	9	.	.	PUNCT
ajst-31202	141	1	doi	doi	NOUN
ajst-31202	141	2	:	:	PUNCT
ajst-31202	141	3	10.1038	10.1038	NUM
ajst-31202	141	4	/	/	SYM
ajst-31202	141	5	nmeth.4179	nmeth.4179	PROPN
ajst-31202	141	6	.	.	PUNCT
ajst-31202	142	1	[	[	X
ajst-31202	142	2	11	11	NUM
ajst-31202	142	3	]	]	PUNCT
ajst-31202	142	4	wu	wu	PROPN
ajst-31202	142	5	a	a	DET
ajst-31202	142	6	r	r	PROPN
ajst-31202	142	7	,	,	PUNCT
ajst-31202	142	8	neff	neff	PROPN
ajst-31202	142	9	n	n	PROPN
ajst-31202	142	10	f	f	PROPN
ajst-31202	142	11	,	,	PUNCT
ajst-31202	142	12	kalisky	kalisky	PROPN
ajst-31202	142	13	t	t	PROPN
ajst-31202	142	14	,	,	PUNCT
ajst-31202	142	15	et	et	PROPN
ajst-31202	142	16	al	al	PROPN
ajst-31202	142	17	.	.	PROPN
ajst-31202	143	1	quantitative	quantitative	ADJ
ajst-31202	143	2	assessment	assessment	NOUN
ajst-31202	143	3	of	of	ADP
ajst-31202	143	4	single	single	ADJ
ajst-31202	143	5	-	-	PUNCT
ajst-31202	143	6	cell	cell	NOUN
ajst-31202	143	7	rna	rna	NOUN
ajst-31202	143	8	-	-	PUNCT
ajst-31202	143	9	sequencing	sequence	VERB
ajst-31202	143	10	methods[j	methods[j	NOUN
ajst-31202	143	11	]	]	PUNCT
ajst-31202	143	12	.	.	PUNCT
ajst-31202	144	1	nature	nature	NOUN
ajst-31202	144	2	methods	method	NOUN
ajst-31202	144	3	,	,	PUNCT
ajst-31202	144	4	2014	2014	NUM
ajst-31202	144	5	,	,	PUNCT
ajst-31202	144	6	11(1	11(1	NUM
ajst-31202	144	7	):	):	PUNCT
ajst-31202	144	8	41–46	41–46	NUM
ajst-31202	144	9	.	.	PUNCT
ajst-31202	144	10	doi	doi	NOUN
ajst-31202	144	11	:	:	PUNCT
ajst-31202	144	12	10.1038	10.1038	NUM
ajst-31202	144	13	/	/	SYM
ajst-31202	144	14	nmeth.2694	nmeth.2694	PROPN
ajst-31202	145	1	[	[	X
ajst-31202	145	2	12	12	NUM
ajst-31202	145	3	]	]	PUNCT
ajst-31202	145	4	fluidigm	fluidigm	NOUN
ajst-31202	145	5	corporation	corporation	NOUN
ajst-31202	145	6	.	.	PUNCT
ajst-31202	146	1	using	use	VERB
ajst-31202	146	2	the	the	DET
ajst-31202	146	3	c1	c1	NOUN
ajst-31202	146	4	system	system	NOUN
ajst-31202	146	5	to	to	PART
ajst-31202	146	6	generate	generate	VERB
ajst-31202	146	7	single	single	ADJ
ajst-31202	146	8	-	-	PUNCT
ajst-31202	146	9	cell	cell	NOUN
ajst-31202	146	10	cdna	cdna	PROPN
ajst-31202	146	11	libraries	library	NOUN
ajst-31202	146	12	for	for	ADP
ajst-31202	146	13	mrna	mrna	PROPN
ajst-31202	146	14	sequencing[eb	sequencing[eb	PROPN
ajst-31202	146	15	/	/	SYM
ajst-31202	146	16	ol	ol	PROPN
ajst-31202	146	17	]	]	X
ajst-31202	146	18	.	.	PUNCT
ajst-31202	147	1	2014	2014	NUM
ajst-31202	147	2	.	.	PUNCT
ajst-31202	148	1	[	[	X
ajst-31202	148	2	13	13	NUM
ajst-31202	148	3	]	]	X
ajst-31202	148	4	islam	islam	PROPN
ajst-31202	148	5	s	s	PROPN
ajst-31202	148	6	,	,	PUNCT
ajst-31202	148	7	kjällquist	kjällquist	NOUN
ajst-31202	148	8	u	u	NOUN
ajst-31202	148	9	,	,	PUNCT
ajst-31202	148	10	moliner	moliner	NOUN
ajst-31202	148	11	a	a	PRON
ajst-31202	148	12	,	,	PUNCT
ajst-31202	148	13	et	et	PROPN
ajst-31202	148	14	al	al	PROPN
ajst-31202	148	15	.	.	PROPN
ajst-31202	149	1	highly	highly	ADV
ajst-31202	149	2	multiplexed	multiplexed	ADJ
ajst-31202	149	3	and	and	CCONJ
ajst-31202	149	4	strand	strand	NOUN
ajst-31202	149	5	-	-	PUNCT
ajst-31202	149	6	specific	specific	ADJ
ajst-31202	149	7	single	single	ADJ
ajst-31202	149	8	-	-	PUNCT
ajst-31202	149	9	cell	cell	NOUN
ajst-31202	149	10	rna	rna	NOUN
ajst-31202	149	11	5	5	NUM
ajst-31202	149	12	'	'	PART
ajst-31202	149	13	end	end	NOUN
ajst-31202	149	14	sequencing[j	sequencing[j	NOUN
ajst-31202	149	15	]	]	PUNCT
ajst-31202	149	16	.	.	PUNCT
ajst-31202	150	1	nature	nature	PROPN
ajst-31202	150	2	protocols	protocol	NOUN
ajst-31202	150	3	,	,	PUNCT
ajst-31202	150	4	2012	2012	NUM
ajst-31202	150	5	,	,	PUNCT
ajst-31202	150	6	7(5	7(5	NUM
ajst-31202	150	7	):	):	PUNCT
ajst-31202	150	8	813–828	813–828	NUM
ajst-31202	150	9	.	.	PUNCT
ajst-31202	151	1	doi	doi	NOUN
ajst-31202	151	2	:	:	PUNCT
ajst-31202	151	3	10.1038	10.1038	NUM
ajst-31202	151	4	/	/	SYM
ajst-31202	151	5	nprot.2012.022	nprot.2012.022	NOUN
ajst-31202	151	6	.	.	PUNCT
ajst-31202	152	1	[	[	X
ajst-31202	152	2	14	14	NUM
ajst-31202	152	3	]	]	X
ajst-31202	152	4	yamawaki	yamawaki	NOUN
ajst-31202	152	5	t	t	PROPN
ajst-31202	152	6	m	m	PROPN
ajst-31202	152	7	,	,	PUNCT
ajst-31202	152	8	liu	liu	PROPN
ajst-31202	152	9	c	c	PROPN
ajst-31202	152	10	c	c	PROPN
ajst-31202	152	11	,	,	PUNCT
ajst-31202	152	12	ito	ito	PROPN
ajst-31202	152	13	t	t	PROPN
ajst-31202	152	14	,	,	PUNCT
ajst-31202	152	15	et	et	PROPN
ajst-31202	152	16	al	al	PROPN
ajst-31202	152	17	.	.	PUNCT
ajst-31202	153	1	systematic	systematic	ADJ
ajst-31202	153	2	comparison	comparison	NOUN
ajst-31202	153	3	of	of	ADP
ajst-31202	153	4	high	high	ADJ
ajst-31202	153	5	-	-	PUNCT
ajst-31202	153	6	throughput	throughput	NOUN
ajst-31202	153	7	single	single	ADJ
ajst-31202	153	8	-	-	PUNCT
ajst-31202	153	9	cell	cell	NOUN
ajst-31202	153	10	rna	rna	NOUN
ajst-31202	153	11	-	-	PUNCT
ajst-31202	153	12	seq	seq	NOUN
ajst-31202	153	13	methods	method	NOUN
ajst-31202	153	14	for	for	ADP
ajst-31202	153	15	immune	immune	ADJ
ajst-31202	153	16	cell	cell	NOUN
ajst-31202	153	17	profiling[j	profiling[j	NOUN
ajst-31202	153	18	]	]	PUNCT
ajst-31202	153	19	.	.	PUNCT
ajst-31202	154	1	bmc	bmc	PROPN
ajst-31202	154	2	genomics	genomic	NOUN
ajst-31202	154	3	,	,	PUNCT
ajst-31202	154	4	2021	2021	NUM
ajst-31202	154	5	,	,	PUNCT
ajst-31202	154	6	22(1	22(1	NUM
ajst-31202	154	7	):	):	PUNCT
ajst-31202	154	8	66	66	NUM
ajst-31202	154	9	.	.	PUNCT
ajst-31202	155	1	doi	doi	NOUN
ajst-31202	155	2	:	:	PUNCT
ajst-31202	155	3	10.1186	10.1186	NUM
ajst-31202	155	4	/	/	SYM
ajst-31202	155	5	s12864	s12864	PROPN
ajst-31202	155	6	-	-	PUNCT
ajst-31202	155	7	020	020	NUM
ajst-31202	155	8	-	-	PUNCT
ajst-31202	155	9	07358	07358	NUM
ajst-31202	155	10	-	-	PUNCT
ajst-31202	155	11	4	4	NUM
ajst-31202	155	12	.	.	PUNCT
ajst-31202	156	1	[	[	X
ajst-31202	156	2	15	15	NUM
ajst-31202	156	3	]	]	X
ajst-31202	156	4	zhang	zhang	PROPN
ajst-31202	156	5	x	x	PROPN
ajst-31202	156	6	,	,	PUNCT
ajst-31202	156	7	li	li	PROPN
ajst-31202	156	8	t	t	PROPN
ajst-31202	156	9	,	,	PUNCT
ajst-31202	156	10	liu	liu	PROPN
ajst-31202	156	11	f	f	PROPN
ajst-31202	156	12	,	,	PUNCT
ajst-31202	156	13	et	et	PROPN
ajst-31202	156	14	al	al	PROPN
ajst-31202	156	15	.	.	PROPN
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ajst-31202	156	17	analysis	analysis	NOUN
ajst-31202	156	18	of	of	ADP
ajst-31202	156	19	droplet	droplet	ADJ
ajst-31202	156	20	-	-	PUNCT
ajst-31202	156	21	based	base	VERB
ajst-31202	156	22	ultra	ultra	ADJ
ajst-31202	156	23	-	-	ADJ
ajst-31202	156	24	high	high	ADJ
ajst-31202	156	25	-	-	PUNCT
ajst-31202	156	26	throughput	throughput	NOUN
ajst-31202	156	27	single	single	ADJ
ajst-31202	156	28	-	-	PUNCT
ajst-31202	156	29	cell	cell	NOUN
ajst-31202	156	30	rna	rna	NOUN
ajst-31202	156	31	-	-	PUNCT
ajst-31202	156	32	seq	seq	NOUN
ajst-31202	156	33	systems[j	systems[j	PROPN
ajst-31202	156	34	]	]	PUNCT
ajst-31202	156	35	.	.	PUNCT
ajst-31202	157	1	molecular	molecular	ADJ
ajst-31202	157	2	cell	cell	NOUN
ajst-31202	157	3	,	,	PUNCT
ajst-31202	157	4	2019	2019	NUM
ajst-31202	157	5	,	,	PUNCT
ajst-31202	157	6	73(1	73(1	NUM
ajst-31202	157	7	):	):	PUNCT
ajst-31202	157	8	130–142.e5	130–142.e5	NUM
ajst-31202	157	9	.	.	PUNCT
ajst-31202	158	1	doi	doi	NOUN
ajst-31202	158	2	:	:	PUNCT
ajst-31202	158	3	10.1016	10.1016	NUM
ajst-31202	158	4	/	/	SYM
ajst-31202	158	5	j.molcel.2018.10.020	j.molcel.2018.10.020	X
ajst-31202	158	6	.	.	PUNCT
ajst-31202	159	1	[	[	X
ajst-31202	159	2	16	16	NUM
ajst-31202	159	3	]	]	PUNCT
ajst-31202	159	4	gall	gall	NOUN
ajst-31202	159	5	j	j	PROPN
ajst-31202	159	6	g	g	PROPN
ajst-31202	159	7	,	,	PUNCT
ajst-31202	159	8	pardue	pardue	PROPN
ajst-31202	159	9	m	m	PROPN
ajst-31202	159	10	l.	l.	NOUN
ajst-31202	159	11	formation	formation	NOUN
ajst-31202	159	12	and	and	CCONJ
ajst-31202	159	13	detection	detection	NOUN
ajst-31202	159	14	of	of	ADP
ajst-31202	159	15	rnadna	rnadna	NOUN
ajst-31202	159	16	hybrid	hybrid	ADJ
ajst-31202	159	17	molecules	molecule	NOUN
ajst-31202	159	18	in	in	ADP
ajst-31202	159	19	cytological	cytological	ADJ
ajst-31202	159	20	preparations[j	preparations[j	PROPN
ajst-31202	159	21	]	]	PUNCT
ajst-31202	159	22	.	.	PUNCT
ajst-31202	160	1	proceedings	proceeding	NOUN
ajst-31202	160	2	of	of	ADP
ajst-31202	160	3	the	the	DET
ajst-31202	160	4	national	national	PROPN
ajst-31202	160	5	academy	academy	PROPN
ajst-31202	160	6	of	of	ADP
ajst-31202	160	7	sciences	sciences	PROPN
ajst-31202	160	8	,	,	PUNCT
ajst-31202	160	9	1969	1969	NUM
ajst-31202	160	10	,	,	PUNCT
ajst-31202	160	11	63(2	63(2	NUM
ajst-31202	160	12	):	):	PUNCT
ajst-31202	160	13	378–383	378–383	NUM
ajst-31202	160	14	.	.	PUNCT
ajst-31202	161	1	doi	doi	NOUN
ajst-31202	161	2	:	:	PUNCT
ajst-31202	161	3	10.1073	10.1073	NUM
ajst-31202	161	4	/	/	SYM
ajst-31202	161	5	pnas.63.2.378	pnas.63.2.378	NUM
ajst-31202	161	6	.	.	PUNCT
ajst-31202	162	1	[	[	X
ajst-31202	162	2	17	17	NUM
ajst-31202	162	3	]	]	X
ajst-31202	162	4	ke	ke	NOUN
ajst-31202	162	5	r	r	NOUN
ajst-31202	162	6	,	,	PUNCT
ajst-31202	162	7	mignardi	mignardi	PROPN
ajst-31202	162	8	m	m	PROPN
ajst-31202	162	9	,	,	PUNCT
ajst-31202	162	10	pacureanu	pacureanu	VERB
ajst-31202	162	11	a	a	PRON
ajst-31202	162	12	,	,	PUNCT
ajst-31202	162	13	et	et	PROPN
ajst-31202	162	14	al	al	PROPN
ajst-31202	162	15	.	.	PROPN
ajst-31202	163	1	in	in	ADP
ajst-31202	163	2	situ	situ	NOUN
ajst-31202	163	3	sequencing	sequencing	NOUN
ajst-31202	163	4	for	for	ADP
ajst-31202	163	5	rna	rna	NOUN
ajst-31202	163	6	analysis	analysis	NOUN
ajst-31202	163	7	in	in	ADP
ajst-31202	163	8	preserved	preserve	VERB
ajst-31202	163	9	tissue	tissue	NOUN
ajst-31202	163	10	and	and	CCONJ
ajst-31202	163	11	cells[j	cells[j	NOUN
ajst-31202	163	12	]	]	PUNCT
ajst-31202	163	13	.	.	PUNCT
ajst-31202	164	1	nature	nature	NOUN
ajst-31202	164	2	methods	method	NOUN
ajst-31202	164	3	,	,	PUNCT
ajst-31202	164	4	2013	2013	NUM
ajst-31202	164	5	,	,	PUNCT
ajst-31202	164	6	10(9	10(9	NUM
ajst-31202	164	7	):	):	PUNCT
ajst-31202	164	8	857–860	857–860	PROPN
ajst-31202	164	9	.	.	PUNCT
ajst-31202	165	1	doi	doi	NOUN
ajst-31202	165	2	:	:	PUNCT
ajst-31202	165	3	10.1038	10.1038	NUM
ajst-31202	165	4	/	/	SYM
ajst-31202	165	5	nmeth.2563	nmeth.2563	PROPN
ajst-31202	165	6	.	.	PUNCT
ajst-31202	166	1	[	[	X
ajst-31202	166	2	18	18	NUM
ajst-31202	166	3	]	]	PUNCT
ajst-31202	166	4	kamenev	kamenev	PROPN
ajst-31202	166	5	p	p	PROPN
ajst-31202	166	6	,	,	PUNCT
ajst-31202	166	7	artemov	artemov	ADJ
ajst-31202	166	8	a	a	DET
ajst-31202	166	9	v	v	NOUN
ajst-31202	166	10	,	,	PUNCT
ajst-31202	166	11	kastriti	kastriti	PROPN
ajst-31202	166	12	m	m	PROPN
ajst-31202	166	13	e	e	NOUN
ajst-31202	166	14	,	,	PUNCT
ajst-31202	166	15	et	et	PROPN
ajst-31202	166	16	al	al	PROPN
ajst-31202	166	17	.	.	PUNCT
ajst-31202	166	18	single	single	ADJ
ajst-31202	166	19	-	-	PUNCT
ajst-31202	166	20	cell	cell	NOUN
ajst-31202	166	21	transcriptomics	transcriptomic	NOUN
ajst-31202	166	22	of	of	ADP
ajst-31202	166	23	human	human	ADJ
ajst-31202	166	24	embryos	embryo	NOUN
ajst-31202	166	25	identifies	identify	VERB
ajst-31202	166	26	multiple	multiple	ADJ
ajst-31202	166	27	sympathoblast	sympathoblast	ADJ
ajst-31202	166	28	lineages	lineage	NOUN
ajst-31202	166	29	with	with	ADP
ajst-31202	166	30	potential	potential	ADJ
ajst-31202	166	31	implications	implication	NOUN
ajst-31202	166	32	for	for	ADP
ajst-31202	166	33	neuroblastoma	neuroblastoma	ADJ
ajst-31202	166	34	origin[j	origin[j	PROPN
ajst-31202	166	35	]	]	PUNCT
ajst-31202	166	36	.	.	PUNCT
ajst-31202	167	1	nature	nature	NOUN
ajst-31202	167	2	genetics	genetic	NOUN
ajst-31202	167	3	,	,	PUNCT
ajst-31202	167	4	2021	2021	NUM
ajst-31202	167	5	,	,	PUNCT
ajst-31202	167	6	53(5	53(5	NUM
ajst-31202	167	7	):	):	PUNCT
ajst-31202	167	8	694	694	NUM
ajst-31202	167	9	–	–	PUNCT
ajst-31202	167	10	706	706	NUM
ajst-31202	167	11	.	.	PUNCT
ajst-31202	167	12	doi	doi	NOUN
ajst-31202	167	13	:	:	PUNCT
ajst-31202	167	14	10.1038	10.1038	NUM
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ajst-31202	167	17	-	-	PUNCT
ajst-31202	167	18	021	021	NUM
ajst-31202	167	19	-	-	PUNCT
ajst-31202	167	20	00818	00818	NUM
ajst-31202	167	21	-	-	PUNCT
ajst-31202	167	22	x.	x.	NOUN
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ajst-31202	168	3	]	]	PUNCT
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ajst-31202	168	6	y	y	PROPN
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ajst-31202	168	9	j	j	PROPN
ajst-31202	168	10	d	d	PROPN
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ajst-31202	168	13	c	c	PROPN
ajst-31202	168	14	j	j	PROPN
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ajst-31202	168	18	.	.	PROPN
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ajst-31202	168	20	effects	effect	NOUN
ajst-31202	168	21	and	and	CCONJ
ajst-31202	168	22	the	the	DET
ajst-31202	168	23	effective	effective	ADJ
ajst-31202	168	24	design	design	NOUN
ajst-31202	168	25	of	of	ADP
ajst-31202	168	26	single	single	ADJ
ajst-31202	168	27	-	-	PUNCT
ajst-31202	168	28	cell	cell	NOUN
ajst-31202	168	29	gene	gene	NOUN
ajst-31202	168	30	expression	expression	NOUN
ajst-31202	168	31	studies[j	studies[j	PROPN
ajst-31202	168	32	]	]	PUNCT
ajst-31202	168	33	.	.	PUNCT
ajst-31202	169	1	scientific	scientific	ADJ
ajst-31202	169	2	reports	report	NOUN
ajst-31202	169	3	,	,	PUNCT
ajst-31202	169	4	2017	2017	NUM
ajst-31202	169	5	,	,	PUNCT
ajst-31202	169	6	7(1	7(1	NUM
ajst-31202	169	7	):	):	PUNCT
ajst-31202	169	8	39921	39921	NUM
ajst-31202	169	9	.	.	PUNCT
ajst-31202	170	1	doi	doi	NOUN
ajst-31202	170	2	:	:	PUNCT
ajst-31202	170	3	10.1038	10.1038	NUM
ajst-31202	170	4	/	/	SYM
ajst-31202	170	5	srep39921	srep39921	PROPN
ajst-31202	170	6	.	.	PUNCT
ajst-31202	171	1	[	[	X
ajst-31202	171	2	20	20	NUM
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ajst-31202	171	5	k	k	PROPN
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ajst-31202	171	10	b	b	PROPN
ajst-31202	171	11	,	,	PUNCT
ajst-31202	171	12	saraiva	saraiva	NOUN
ajst-31202	171	13	l	l	NOUN
ajst-31202	171	14	r	r	NOUN
ajst-31202	171	15	,	,	PUNCT
ajst-31202	171	16	et	et	PROPN
ajst-31202	172	1	al	al	PROPN
ajst-31202	172	2	.	.	PROPN
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ajst-31202	172	4	-	-	PUNCT
ajst-31202	172	5	throughput	throughput	NOUN
ajst-31202	172	6	spatial	spatial	ADJ
ajst-31202	172	7	mapping	mapping	NOUN
ajst-31202	172	8	of	of	ADP
ajst-31202	172	9	single	single	ADJ
ajst-31202	172	10	-	-	PUNCT
ajst-31202	172	11	cell	cell	NOUN
ajst-31202	172	12	rna	rna	NOUN
ajst-31202	172	13	-	-	PUNCT
ajst-31202	172	14	seq	seq	NOUN
ajst-31202	172	15	data	datum	NOUN
ajst-31202	172	16	to	to	ADP
ajst-31202	172	17	tissue	tissue	NOUN
ajst-31202	172	18	of	of	ADP
ajst-31202	172	19	origin[j	origin[j	PROPN
ajst-31202	172	20	]	]	PUNCT
ajst-31202	172	21	.	.	PUNCT
ajst-31202	173	1	nature	nature	NOUN
ajst-31202	173	2	biotechnology	biotechnology	NOUN
ajst-31202	173	3	,	,	PUNCT
ajst-31202	173	4	2015	2015	NUM
ajst-31202	173	5	,	,	PUNCT
ajst-31202	173	6	33(5	33(5	NUM
ajst-31202	173	7	):	):	PUNCT
ajst-31202	173	8	503–509	503–509	NUM
ajst-31202	173	9	.	.	PUNCT
ajst-31202	174	1	doi	doi	NOUN
ajst-31202	174	2	:	:	PUNCT
ajst-31202	174	3	10.1038	10.1038	NUM
ajst-31202	174	4	/	/	SYM
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