id	sid	tid	token	lemma	pos
ajst-32250	1	1	38	38	NUM
ajst-32250	1	2	engineering	engineering	NOUN
ajst-32250	1	3	bacteriophages	bacteriophage	NOUN
ajst-32250	1	4	for	for	ADP
ajst-32250	1	5	hiv	hiv	PROPN
ajst-32250	1	6	treatment	treatment	NOUN
ajst-32250	1	7	:	:	PUNCT
ajst-32250	1	8	from	from	ADP
ajst-32250	1	9	gene	gene	NOUN
ajst-32250	1	10	delivery	delivery	NOUN
ajst-32250	1	11	to	to	ADP
ajst-32250	1	12	immune	immune	ADJ
ajst-32250	1	13	modulation	modulation	NOUN
ajst-32250	1	14	hanwen	hanwen	NOUN
ajst-32250	1	15	guo	guo	PROPN
ajst-32250	1	16	department	department	PROPN
ajst-32250	1	17	of	of	ADP
ajst-32250	1	18	isa	isa	PROPN
ajst-32250	1	19	wuhan	wuhan	PROPN
ajst-32250	1	20	wenhua	wenhua	PROPN
ajst-32250	1	21	international	international	PROPN
ajst-32250	1	22	school	school	PROPN
ajst-32250	1	23	,	,	PUNCT
ajst-32250	1	24	wuhan	wuhan	PROPN
ajst-32250	1	25	,	,	PUNCT
ajst-32250	1	26	hubei	hubei	PROPN
ajst-32250	1	27	,	,	PUNCT
ajst-32250	1	28	china	china	PROPN
ajst-32250	1	29	1413849802@qq.com	1413849802@qq.com	NUM
ajst-32250	1	30	abstract	abstract	ADJ
ajst-32250	1	31	.	.	PUNCT
ajst-32250	2	1	the	the	DET
ajst-32250	2	2	application	application	NOUN
ajst-32250	2	3	of	of	ADP
ajst-32250	2	4	bacteriophage	bacteriophage	NOUN
ajst-32250	2	5	targeting	target	VERB
ajst-32250	2	6	in	in	ADP
ajst-32250	2	7	hiv	hiv	PROPN
ajst-32250	2	8	therapy	therapy	NOUN
ajst-32250	2	9	is	be	AUX
ajst-32250	2	10	an	an	DET
ajst-32250	2	11	innovative	innovative	ADJ
ajst-32250	2	12	research	research	NOUN
ajst-32250	2	13	area	area	NOUN
ajst-32250	2	14	exploring	explore	VERB
ajst-32250	2	15	the	the	DET
ajst-32250	2	16	potential	potential	NOUN
ajst-32250	2	17	of	of	ADP
ajst-32250	2	18	phages	phage	NOUN
ajst-32250	2	19	—	—	PUNCT
ajst-32250	2	20	viruses	virus	NOUN
ajst-32250	2	21	that	that	PRON
ajst-32250	2	22	typically	typically	ADV
ajst-32250	2	23	target	target	VERB
ajst-32250	2	24	bacteria	bacteria	NOUN
ajst-32250	2	25	—	—	PUNCT
ajst-32250	2	26	to	to	PART
ajst-32250	2	27	combat	combat	VERB
ajst-32250	2	28	viral	viral	ADJ
ajst-32250	2	29	infections	infection	NOUN
ajst-32250	2	30	,	,	PUNCT
ajst-32250	2	31	including	include	VERB
ajst-32250	2	32	hiv	hiv	PROPN
ajst-32250	2	33	.	.	PUNCT
ajst-32250	3	1	bacteriophage	bacteriophage	NOUN
ajst-32250	3	2	therapy	therapy	NOUN
ajst-32250	3	3	,	,	PUNCT
ajst-32250	3	4	a	a	DET
ajst-32250	3	5	creative	creative	ADJ
ajst-32250	3	6	approach	approach	NOUN
ajst-32250	3	7	to	to	ADP
ajst-32250	3	8	tackling	tackle	VERB
ajst-32250	3	9	viral	viral	ADJ
ajst-32250	3	10	infections	infection	NOUN
ajst-32250	3	11	,	,	PUNCT
ajst-32250	3	12	has	have	AUX
ajst-32250	3	13	gained	gain	VERB
ajst-32250	3	14	attention	attention	NOUN
ajst-32250	3	15	in	in	ADP
ajst-32250	3	16	the	the	DET
ajst-32250	3	17	context	context	NOUN
ajst-32250	3	18	of	of	ADP
ajst-32250	3	19	hiv	hiv	PROPN
ajst-32250	3	20	treatment	treatment	NOUN
ajst-32250	3	21	.	.	PUNCT
ajst-32250	4	1	one	one	NUM
ajst-32250	4	2	promising	promise	VERB
ajst-32250	4	3	strategy	strategy	NOUN
ajst-32250	4	4	involves	involve	VERB
ajst-32250	4	5	using	use	VERB
ajst-32250	4	6	gene	gene	NOUN
ajst-32250	4	7	delivery	delivery	NOUN
ajst-32250	4	8	systems	system	NOUN
ajst-32250	4	9	where	where	SCONJ
ajst-32250	4	10	engineered	engineer	VERB
ajst-32250	4	11	phages	phage	NOUN
ajst-32250	4	12	could	could	AUX
ajst-32250	4	13	serve	serve	VERB
ajst-32250	4	14	as	as	ADP
ajst-32250	4	15	vectors	vector	NOUN
ajst-32250	4	16	for	for	ADP
ajst-32250	4	17	delivering	deliver	VERB
ajst-32250	4	18	therapeutic	therapeutic	ADJ
ajst-32250	4	19	genes	gene	NOUN
ajst-32250	4	20	or	or	CCONJ
ajst-32250	4	21	rna	rna	NOUN
ajst-32250	4	22	molecules	molecule	NOUN
ajst-32250	4	23	,	,	PUNCT
ajst-32250	4	24	potentially	potentially	ADV
ajst-32250	4	25	silencing	silence	VERB
ajst-32250	4	26	hiv	hiv	NOUN
ajst-32250	4	27	replication	replication	NOUN
ajst-32250	4	28	or	or	CCONJ
ajst-32250	4	29	enhancing	enhance	VERB
ajst-32250	4	30	immune	immune	ADJ
ajst-32250	4	31	responses	response	NOUN
ajst-32250	4	32	.	.	PUNCT
ajst-32250	5	1	moreover	moreover	ADV
ajst-32250	5	2	,	,	PUNCT
ajst-32250	5	3	the	the	DET
ajst-32250	5	4	application	application	NOUN
ajst-32250	5	5	of	of	ADP
ajst-32250	5	6	crispr	crispr	ADJ
ajst-32250	5	7	technology	technology	NOUN
ajst-32250	5	8	in	in	ADP
ajst-32250	5	9	conjunction	conjunction	NOUN
ajst-32250	5	10	with	with	ADP
ajst-32250	5	11	phage	phage	NOUN
ajst-32250	5	12	therapy	therapy	NOUN
ajst-32250	5	13	is	be	AUX
ajst-32250	5	14	being	be	AUX
ajst-32250	5	15	investigated	investigate	VERB
ajst-32250	5	16	to	to	PART
ajst-32250	5	17	edit	edit	VERB
ajst-32250	5	18	viral	viral	ADJ
ajst-32250	5	19	genomes	genome	NOUN
ajst-32250	5	20	within	within	ADP
ajst-32250	5	21	infected	infected	ADJ
ajst-32250	5	22	cells	cell	NOUN
ajst-32250	5	23	,	,	PUNCT
ajst-32250	5	24	providing	provide	VERB
ajst-32250	5	25	a	a	DET
ajst-32250	5	26	precision	precision	NOUN
ajst-32250	5	27	tool	tool	NOUN
ajst-32250	5	28	for	for	ADP
ajst-32250	5	29	controlling	control	VERB
ajst-32250	5	30	hiv	hiv	PROPN
ajst-32250	5	31	at	at	ADP
ajst-32250	5	32	the	the	DET
ajst-32250	5	33	genetic	genetic	ADJ
ajst-32250	5	34	level	level	NOUN
ajst-32250	5	35	.	.	PUNCT
ajst-32250	6	1	such	such	ADJ
ajst-32250	6	2	approaches	approach	NOUN
ajst-32250	6	3	may	may	AUX
ajst-32250	6	4	complement	complement	VERB
ajst-32250	6	5	existing	exist	VERB
ajst-32250	6	6	antiretroviral	antiretroviral	ADJ
ajst-32250	6	7	therapy	therapy	NOUN
ajst-32250	6	8	(	(	PUNCT
ajst-32250	6	9	art	art	NOUN
ajst-32250	6	10	)	)	PUNCT
ajst-32250	6	11	,	,	PUNCT
ajst-32250	6	12	which	which	PRON
ajst-32250	6	13	is	be	AUX
ajst-32250	6	14	often	often	ADV
ajst-32250	6	15	hindered	hinder	VERB
ajst-32250	6	16	by	by	ADP
ajst-32250	6	17	issues	issue	NOUN
ajst-32250	6	18	like	like	ADP
ajst-32250	6	19	drug	drug	NOUN
ajst-32250	6	20	resistance	resistance	NOUN
ajst-32250	6	21	and	and	CCONJ
ajst-32250	6	22	side	side	NOUN
ajst-32250	6	23	effects	effect	NOUN
ajst-32250	6	24	.	.	PUNCT
ajst-32250	7	1	keywords	keyword	NOUN
ajst-32250	7	2	:	:	PUNCT
ajst-32250	7	3	bacteriophage	bacteriophage	NOUN
ajst-32250	7	4	therapy	therapy	NOUN
ajst-32250	7	5	;	;	PUNCT
ajst-32250	7	6	hiv	hiv	PROPN
ajst-32250	7	7	;	;	PUNCT
ajst-32250	7	8	gene	gene	NOUN
ajst-32250	7	9	delivery	delivery	NOUN
ajst-32250	7	10	;	;	PUNCT
ajst-32250	7	11	crispr	crispr	ADJ
ajst-32250	7	12	;	;	PUNCT
ajst-32250	7	13	antiretroviral	antiretroviral	ADJ
ajst-32250	7	14	therapy	therapy	NOUN
ajst-32250	7	15	(	(	PUNCT
ajst-32250	7	16	art	art	NOUN
ajst-32250	7	17	)	)	PUNCT
ajst-32250	7	18	.	.	PUNCT
ajst-32250	8	1	1	1	X
ajst-32250	8	2	.	.	X
ajst-32250	8	3	introduction	introduction	NOUN
ajst-32250	8	4	human	human	ADJ
ajst-32250	8	5	immunodeficiency	immunodeficiency	NOUN
ajst-32250	8	6	virus	virus	NOUN
ajst-32250	8	7	(	(	PUNCT
ajst-32250	8	8	hiv	hiv	NOUN
ajst-32250	8	9	)	)	PUNCT
ajst-32250	8	10	infection	infection	NOUN
ajst-32250	8	11	remains	remain	VERB
ajst-32250	8	12	one	one	NUM
ajst-32250	8	13	of	of	ADP
ajst-32250	8	14	the	the	DET
ajst-32250	8	15	most	most	ADV
ajst-32250	8	16	pressing	pressing	ADJ
ajst-32250	8	17	global	global	ADJ
ajst-32250	8	18	health	health	NOUN
ajst-32250	8	19	challenges	challenge	NOUN
ajst-32250	8	20	,	,	PUNCT
ajst-32250	8	21	with	with	ADP
ajst-32250	8	22	more	more	ADJ
ajst-32250	8	23	than	than	ADP
ajst-32250	8	24	38	38	NUM
ajst-32250	8	25	million	million	NUM
ajst-32250	8	26	people	people	NOUN
ajst-32250	8	27	living	live	VERB
ajst-32250	8	28	with	with	ADP
ajst-32250	8	29	hiv	hiv	PROPN
ajst-32250	8	30	worldwide	worldwide	ADV
ajst-32250	8	31	.	.	PUNCT
ajst-32250	9	1	despite	despite	SCONJ
ajst-32250	9	2	remarkable	remarkable	ADJ
ajst-32250	9	3	progress	progress	NOUN
ajst-32250	9	4	in	in	ADP
ajst-32250	9	5	treatment	treatment	NOUN
ajst-32250	9	6	,	,	PUNCT
ajst-32250	9	7	particularly	particularly	ADV
ajst-32250	9	8	through	through	ADP
ajst-32250	9	9	antiretroviral	antiretroviral	ADJ
ajst-32250	9	10	therapy	therapy	NOUN
ajst-32250	9	11	(	(	PUNCT
ajst-32250	9	12	art	art	NOUN
ajst-32250	9	13	)	)	PUNCT
ajst-32250	9	14	,	,	PUNCT
ajst-32250	9	15	current	current	ADJ
ajst-32250	9	16	regimens	regimen	NOUN
ajst-32250	9	17	are	be	AUX
ajst-32250	9	18	not	not	PART
ajst-32250	9	19	curative	curative	ADJ
ajst-32250	9	20	.	.	PUNCT
ajst-32250	10	1	art	art	NOUN
ajst-32250	10	2	suppresses	suppress	VERB
ajst-32250	10	3	viral	viral	ADJ
ajst-32250	10	4	replication	replication	NOUN
ajst-32250	10	5	but	but	CCONJ
ajst-32250	10	6	can	can	AUX
ajst-32250	10	7	not	not	PART
ajst-32250	10	8	eradicate	eradicate	VERB
ajst-32250	10	9	latent	latent	NOUN
ajst-32250	10	10	reservoirs	reservoir	NOUN
ajst-32250	10	11	,	,	PUNCT
ajst-32250	10	12	and	and	CCONJ
ajst-32250	10	13	long	long	ADJ
ajst-32250	10	14	-	-	PUNCT
ajst-32250	10	15	term	term	NOUN
ajst-32250	10	16	use	use	NOUN
ajst-32250	10	17	is	be	AUX
ajst-32250	10	18	often	often	ADV
ajst-32250	10	19	associated	associate	VERB
ajst-32250	10	20	with	with	ADP
ajst-32250	10	21	drug	drug	NOUN
ajst-32250	10	22	resistance	resistance	NOUN
ajst-32250	10	23	,	,	PUNCT
ajst-32250	10	24	adverse	adverse	ADJ
ajst-32250	10	25	side	side	NOUN
ajst-32250	10	26	effects	effect	NOUN
ajst-32250	10	27	,	,	PUNCT
ajst-32250	10	28	and	and	CCONJ
ajst-32250	10	29	adherence	adherence	NOUN
ajst-32250	10	30	challenges	challenge	NOUN
ajst-32250	10	31	.	.	PUNCT
ajst-32250	11	1	these	these	DET
ajst-32250	11	2	limitations	limitation	NOUN
ajst-32250	11	3	underscore	underscore	VERB
ajst-32250	11	4	the	the	DET
ajst-32250	11	5	urgent	urgent	ADJ
ajst-32250	11	6	need	need	NOUN
ajst-32250	11	7	for	for	ADP
ajst-32250	11	8	innovative	innovative	ADJ
ajst-32250	11	9	therapeutic	therapeutic	ADJ
ajst-32250	11	10	strategies	strategy	NOUN
ajst-32250	11	11	that	that	PRON
ajst-32250	11	12	complement	complement	VERB
ajst-32250	11	13	or	or	CCONJ
ajst-32250	11	14	transcend	transcend	VERB
ajst-32250	11	15	existing	exist	VERB
ajst-32250	11	16	approaches	approach	NOUN
ajst-32250	11	17	.	.	PUNCT
ajst-32250	12	1	bacteriophages	bacteriophage	NOUN
ajst-32250	12	2	—	—	PUNCT
ajst-32250	12	3	viruses	virus	NOUN
ajst-32250	12	4	that	that	PRON
ajst-32250	12	5	naturally	naturally	ADV
ajst-32250	12	6	infect	infect	ADJ
ajst-32250	12	7	bacteria	bacteria	NOUN
ajst-32250	12	8	—	—	PUNCT
ajst-32250	12	9	are	be	AUX
ajst-32250	12	10	gaining	gain	VERB
ajst-32250	12	11	attention	attention	NOUN
ajst-32250	12	12	as	as	ADP
ajst-32250	12	13	unconventional	unconventional	ADJ
ajst-32250	12	14	yet	yet	ADV
ajst-32250	12	15	promising	promising	ADJ
ajst-32250	12	16	tools	tool	NOUN
ajst-32250	12	17	in	in	ADP
ajst-32250	12	18	the	the	DET
ajst-32250	12	19	fight	fight	NOUN
ajst-32250	12	20	against	against	ADP
ajst-32250	12	21	viral	viral	ADJ
ajst-32250	12	22	diseases	disease	NOUN
ajst-32250	12	23	,	,	PUNCT
ajst-32250	12	24	including	include	VERB
ajst-32250	12	25	hiv	hiv	PROPN
ajst-32250	12	26	.	.	PUNCT
ajst-32250	13	1	explored	explore	VERB
ajst-32250	13	2	initially	initially	ADV
ajst-32250	13	3	for	for	ADP
ajst-32250	13	4	antibacterial	antibacterial	ADJ
ajst-32250	13	5	applications	application	NOUN
ajst-32250	13	6	,	,	PUNCT
ajst-32250	13	7	engineered	engineer	VERB
ajst-32250	13	8	phages	phage	NOUN
ajst-32250	13	9	are	be	AUX
ajst-32250	13	10	now	now	ADV
ajst-32250	13	11	being	be	AUX
ajst-32250	13	12	investigated	investigate	VERB
ajst-32250	13	13	as	as	ADP
ajst-32250	13	14	gene	gene	NOUN
ajst-32250	13	15	delivery	delivery	NOUN
ajst-32250	13	16	vectors	vector	NOUN
ajst-32250	13	17	,	,	PUNCT
ajst-32250	13	18	capable	capable	ADJ
ajst-32250	13	19	of	of	ADP
ajst-32250	13	20	transporting	transport	VERB
ajst-32250	13	21	therapeutic	therapeutic	ADJ
ajst-32250	13	22	molecules	molecule	NOUN
ajst-32250	13	23	or	or	CCONJ
ajst-32250	13	24	crispr	crispr	ADJ
ajst-32250	13	25	/	/	SYM
ajst-32250	13	26	cas	cas	NOUN
ajst-32250	13	27	systems	system	NOUN
ajst-32250	13	28	to	to	PART
ajst-32250	13	29	disrupt	disrupt	VERB
ajst-32250	13	30	hiv	hiv	PROPN
ajst-32250	13	31	genomes	genome	NOUN
ajst-32250	13	32	within	within	ADP
ajst-32250	13	33	infected	infected	ADJ
ajst-32250	13	34	cells	cell	NOUN
ajst-32250	13	35	selectively	selectively	ADV
ajst-32250	13	36	.	.	PUNCT
ajst-32250	14	1	additionally	additionally	ADV
ajst-32250	14	2	,	,	PUNCT
ajst-32250	14	3	phage	phage	NOUN
ajst-32250	14	4	-	-	PUNCT
ajst-32250	14	5	derived	derive	VERB
ajst-32250	14	6	enzymes	enzyme	NOUN
ajst-32250	14	7	and	and	CCONJ
ajst-32250	14	8	capsid	capsid	NOUN
ajst-32250	14	9	structures	structure	NOUN
ajst-32250	14	10	offer	offer	VERB
ajst-32250	14	11	potential	potential	NOUN
ajst-32250	14	12	for	for	ADP
ajst-32250	14	13	antiviral	antiviral	ADJ
ajst-32250	14	14	activity	activity	NOUN
ajst-32250	14	15	and	and	CCONJ
ajst-32250	14	16	vaccine	vaccine	NOUN
ajst-32250	14	17	development	development	NOUN
ajst-32250	14	18	,	,	PUNCT
ajst-32250	14	19	while	while	SCONJ
ajst-32250	14	20	phage	phage	NOUN
ajst-32250	14	21	-	-	PUNCT
ajst-32250	14	22	mediated	mediate	VERB
ajst-32250	14	23	immune	immune	ADJ
ajst-32250	14	24	modulation	modulation	NOUN
ajst-32250	14	25	may	may	AUX
ajst-32250	14	26	enhance	enhance	VERB
ajst-32250	14	27	host	host	NOUN
ajst-32250	14	28	defenses	defense	NOUN
ajst-32250	14	29	against	against	ADP
ajst-32250	14	30	hiv	hiv	PROPN
ajst-32250	14	31	.	.	PUNCT
ajst-32250	15	1	[	[	X
ajst-32250	15	2	1	1	X
ajst-32250	15	3	]	]	PUNCT
ajst-32250	15	4	this	this	DET
ajst-32250	15	5	review	review	NOUN
ajst-32250	15	6	explores	explore	VERB
ajst-32250	15	7	the	the	DET
ajst-32250	15	8	emerging	emerge	VERB
ajst-32250	15	9	role	role	NOUN
ajst-32250	15	10	of	of	ADP
ajst-32250	15	11	bacteriophages	bacteriophage	NOUN
ajst-32250	15	12	in	in	ADP
ajst-32250	15	13	hiv	hiv	PROPN
ajst-32250	15	14	therapy	therapy	NOUN
ajst-32250	15	15	.	.	PUNCT
ajst-32250	16	1	we	we	PRON
ajst-32250	16	2	first	first	ADV
ajst-32250	16	3	examine	examine	VERB
ajst-32250	16	4	the	the	DET
ajst-32250	16	5	fundamental	fundamental	ADJ
ajst-32250	16	6	biology	biology	NOUN
ajst-32250	16	7	of	of	ADP
ajst-32250	16	8	phages	phage	NOUN
ajst-32250	16	9	and	and	CCONJ
ajst-32250	16	10	their	their	PRON
ajst-32250	16	11	adaptation	adaptation	NOUN
ajst-32250	16	12	as	as	ADP
ajst-32250	16	13	therapeutic	therapeutic	ADJ
ajst-32250	16	14	vectors	vector	NOUN
ajst-32250	16	15	.	.	PUNCT
ajst-32250	17	1	next	next	ADV
ajst-32250	17	2	,	,	PUNCT
ajst-32250	17	3	we	we	PRON
ajst-32250	17	4	highlight	highlight	VERB
ajst-32250	17	5	recent	recent	ADJ
ajst-32250	17	6	advances	advance	NOUN
ajst-32250	17	7	in	in	ADP
ajst-32250	17	8	gene	gene	NOUN
ajst-32250	17	9	delivery	delivery	NOUN
ajst-32250	17	10	,	,	PUNCT
ajst-32250	17	11	crispr	crispr	NOUN
ajst-32250	17	12	-	-	PUNCT
ajst-32250	17	13	mediated	mediate	VERB
ajst-32250	17	14	genome	genome	NOUN
ajst-32250	17	15	editing	editing	NOUN
ajst-32250	17	16	,	,	PUNCT
ajst-32250	17	17	immunomodulation	immunomodulation	NOUN
ajst-32250	17	18	,	,	PUNCT
ajst-32250	17	19	and	and	CCONJ
ajst-32250	17	20	potential	potential	ADJ
ajst-32250	17	21	synergies	synergy	NOUN
ajst-32250	17	22	between	between	ADP
ajst-32250	17	23	phage	phage	NOUN
ajst-32250	17	24	therapy	therapy	NOUN
ajst-32250	17	25	and	and	CCONJ
ajst-32250	17	26	art	art	NOUN
ajst-32250	17	27	.	.	PUNCT
ajst-32250	18	1	finally	finally	ADV
ajst-32250	18	2	,	,	PUNCT
ajst-32250	18	3	we	we	PRON
ajst-32250	18	4	discuss	discuss	VERB
ajst-32250	18	5	limitations	limitation	NOUN
ajst-32250	18	6	,	,	PUNCT
ajst-32250	18	7	safety	safety	NOUN
ajst-32250	18	8	concerns	concern	NOUN
ajst-32250	18	9	,	,	PUNCT
ajst-32250	18	10	and	and	CCONJ
ajst-32250	18	11	regulatory	regulatory	ADJ
ajst-32250	18	12	hurdles	hurdle	NOUN
ajst-32250	18	13	,	,	PUNCT
ajst-32250	18	14	outlining	outline	VERB
ajst-32250	18	15	the	the	DET
ajst-32250	18	16	future	future	ADJ
ajst-32250	18	17	directions	direction	NOUN
ajst-32250	18	18	required	require	VERB
ajst-32250	18	19	to	to	PART
ajst-32250	18	20	translate	translate	VERB
ajst-32250	18	21	phage	phage	NOUN
ajst-32250	18	22	-	-	PUNCT
ajst-32250	18	23	based	base	VERB
ajst-32250	18	24	strategies	strategy	NOUN
ajst-32250	18	25	into	into	ADP
ajst-32250	18	26	clinical	clinical	ADJ
ajst-32250	18	27	hiv	hiv	PROPN
ajst-32250	18	28	treatment	treatment	NOUN
ajst-32250	18	29	.	.	PUNCT
ajst-32250	19	1	by	by	ADP
ajst-32250	19	2	integrating	integrate	VERB
ajst-32250	19	3	these	these	DET
ajst-32250	19	4	perspectives	perspective	NOUN
ajst-32250	19	5	,	,	PUNCT
ajst-32250	19	6	this	this	DET
ajst-32250	19	7	article	article	NOUN
ajst-32250	19	8	aims	aim	VERB
ajst-32250	19	9	to	to	PART
ajst-32250	19	10	provide	provide	VERB
ajst-32250	19	11	a	a	DET
ajst-32250	19	12	comprehensive	comprehensive	ADJ
ajst-32250	19	13	overview	overview	NOUN
ajst-32250	19	14	of	of	ADP
ajst-32250	19	15	how	how	SCONJ
ajst-32250	19	16	bacteriophage	bacteriophage	NOUN
ajst-32250	19	17	biotechnology	biotechnology	NOUN
ajst-32250	19	18	could	could	AUX
ajst-32250	19	19	open	open	VERB
ajst-32250	19	20	new	new	ADJ
ajst-32250	19	21	frontiers	frontier	NOUN
ajst-32250	19	22	in	in	ADP
ajst-32250	19	23	hiv	hiv	PROPN
ajst-32250	19	24	therapy	therapy	NOUN
ajst-32250	19	25	.	.	PUNCT
ajst-32250	20	1	2	2	NUM
ajst-32250	20	2	.	.	NUM
ajst-32250	20	3	fundamental	fundamental	ADJ
ajst-32250	20	4	mechanisms	mechanism	NOUN
ajst-32250	20	5	of	of	ADP
ajst-32250	20	6	phage	phage	NOUN
ajst-32250	20	7	therapy	therapy	NOUN
ajst-32250	20	8	bacteriophages	bacteriophage	NOUN
ajst-32250	20	9	are	be	AUX
ajst-32250	20	10	viruses	virus	NOUN
ajst-32250	20	11	that	that	PRON
ajst-32250	20	12	infect	infect	VERB
ajst-32250	20	13	bacteria	bacteria	NOUN
ajst-32250	20	14	,	,	PUNCT
ajst-32250	20	15	consisting	consist	VERB
ajst-32250	20	16	of	of	ADP
ajst-32250	20	17	a	a	DET
ajst-32250	20	18	protective	protective	ADJ
ajst-32250	20	19	capsid	capsid	NOUN
ajst-32250	20	20	and	and	CCONJ
ajst-32250	20	21	a	a	DET
ajst-32250	20	22	tail	tail	NOUN
ajst-32250	20	23	sheath	sheath	NOUN
ajst-32250	20	24	that	that	PRON
ajst-32250	20	25	enables	enable	VERB
ajst-32250	20	26	the	the	DET
ajst-32250	20	27	injection	injection	NOUN
ajst-32250	20	28	of	of	ADP
ajst-32250	20	29	genetic	genetic	ADJ
ajst-32250	20	30	material	material	NOUN
ajst-32250	20	31	into	into	ADP
ajst-32250	20	32	host	host	NOUN
ajst-32250	20	33	cells	cell	NOUN
ajst-32250	20	34	.	.	PUNCT
ajst-32250	21	1	their	their	PRON
ajst-32250	21	2	infection	infection	NOUN
ajst-32250	21	3	cycle	cycle	NOUN
ajst-32250	21	4	begins	begin	VERB
ajst-32250	21	5	with	with	ADP
ajst-32250	21	6	attachment	attachment	NOUN
ajst-32250	21	7	,	,	PUNCT
ajst-32250	21	8	where	where	SCONJ
ajst-32250	21	9	the	the	DET
ajst-32250	21	10	phage	phage	NOUN
ajst-32250	21	11	binds	bind	VERB
ajst-32250	21	12	to	to	ADP
ajst-32250	21	13	specific	specific	ADJ
ajst-32250	21	14	receptors	receptor	NOUN
ajst-32250	21	15	on	on	ADP
ajst-32250	21	16	the	the	DET
ajst-32250	21	17	bacterial	bacterial	ADJ
ajst-32250	21	18	surface	surface	NOUN
ajst-32250	21	19	,	,	PUNCT
ajst-32250	21	20	followed	follow	VERB
ajst-32250	21	21	by	by	ADP
ajst-32250	21	22	penetration	penetration	NOUN
ajst-32250	21	23	,	,	PUNCT
ajst-32250	21	24	during	during	ADP
ajst-32250	21	25	which	which	PRON
ajst-32250	21	26	the	the	DET
ajst-32250	21	27	phage	phage	NOUN
ajst-32250	21	28	injects	inject	VERB
ajst-32250	21	29	its	its	PRON
ajst-32250	21	30	dna	dna	NOUN
ajst-32250	21	31	into	into	ADP
ajst-32250	21	32	the	the	DET
ajst-32250	21	33	host	host	NOUN
ajst-32250	21	34	.	.	PUNCT
ajst-32250	22	1	once	once	ADV
ajst-32250	22	2	inside	inside	ADV
ajst-32250	22	3	,	,	PUNCT
ajst-32250	22	4	the	the	DET
ajst-32250	22	5	viral	viral	ADJ
ajst-32250	22	6	genome	genome	NOUN
ajst-32250	22	7	undergoes	undergoe	NOUN
ajst-32250	22	8	replication	replication	NOUN
ajst-32250	22	9	,	,	PUNCT
ajst-32250	22	10	producing	produce	VERB
ajst-32250	22	11	multiple	multiple	ADJ
ajst-32250	22	12	copies	copy	NOUN
ajst-32250	22	13	of	of	ADP
ajst-32250	22	14	dna	dna	NOUN
ajst-32250	22	15	and	and	CCONJ
ajst-32250	22	16	viral	viral	ADJ
ajst-32250	22	17	proteins	protein	NOUN
ajst-32250	22	18	assembled	assemble	VERB
ajst-32250	22	19	into	into	ADP
ajst-32250	22	20	new	new	ADJ
ajst-32250	22	21	39	39	NUM
ajst-32250	22	22	phage	phage	NOUN
ajst-32250	22	23	particles	particle	NOUN
ajst-32250	22	24	.	.	PUNCT
ajst-32250	23	1	the	the	DET
ajst-32250	23	2	cycle	cycle	NOUN
ajst-32250	23	3	culminates	culminate	VERB
ajst-32250	23	4	in	in	ADP
ajst-32250	23	5	lysis	lysis	NOUN
ajst-32250	23	6	,	,	PUNCT
ajst-32250	23	7	where	where	SCONJ
ajst-32250	23	8	the	the	DET
ajst-32250	23	9	host	host	NOUN
ajst-32250	23	10	cell	cell	NOUN
ajst-32250	23	11	is	be	AUX
ajst-32250	23	12	destroyed	destroy	VERB
ajst-32250	23	13	and	and	CCONJ
ajst-32250	23	14	newly	newly	ADV
ajst-32250	23	15	formed	form	VERB
ajst-32250	23	16	phages	phage	NOUN
ajst-32250	23	17	are	be	AUX
ajst-32250	23	18	released	release	VERB
ajst-32250	23	19	to	to	PART
ajst-32250	23	20	infect	infect	VERB
ajst-32250	23	21	other	other	ADJ
ajst-32250	23	22	cells	cell	NOUN
ajst-32250	23	23	.	.	PUNCT
ajst-32250	24	1	this	this	DET
ajst-32250	24	2	natural	natural	ADJ
ajst-32250	24	3	infection	infection	NOUN
ajst-32250	24	4	mechanism	mechanism	NOUN
ajst-32250	24	5	,	,	PUNCT
ajst-32250	24	6	particularly	particularly	ADV
ajst-32250	24	7	the	the	DET
ajst-32250	24	8	process	process	NOUN
ajst-32250	24	9	of	of	ADP
ajst-32250	24	10	genetic	genetic	ADJ
ajst-32250	24	11	material	material	NOUN
ajst-32250	24	12	transfer	transfer	NOUN
ajst-32250	24	13	—	—	PUNCT
ajst-32250	24	14	known	know	VERB
ajst-32250	24	15	as	as	ADP
ajst-32250	24	16	transduction	transduction	NOUN
ajst-32250	24	17	—	—	PUNCT
ajst-32250	24	18	can	can	AUX
ajst-32250	24	19	be	be	AUX
ajst-32250	24	20	exploited	exploit	VERB
ajst-32250	24	21	for	for	ADP
ajst-32250	24	22	therapeutic	therapeutic	ADJ
ajst-32250	24	23	purposes	purpose	NOUN
ajst-32250	24	24	.	.	PUNCT
ajst-32250	25	1	engineered	engineer	VERB
ajst-32250	25	2	bacteriophages	bacteriophage	NOUN
ajst-32250	25	3	can	can	AUX
ajst-32250	25	4	serve	serve	VERB
ajst-32250	25	5	as	as	ADP
ajst-32250	25	6	vectors	vector	NOUN
ajst-32250	25	7	for	for	ADP
ajst-32250	25	8	targeted	target	VERB
ajst-32250	25	9	gene	gene	NOUN
ajst-32250	25	10	delivery	delivery	NOUN
ajst-32250	25	11	:	:	PUNCT
ajst-32250	25	12	their	their	PRON
ajst-32250	25	13	genomes	genome	NOUN
ajst-32250	25	14	may	may	AUX
ajst-32250	25	15	be	be	AUX
ajst-32250	25	16	modified	modify	VERB
ajst-32250	25	17	or	or	CCONJ
ajst-32250	25	18	“	"	PUNCT
ajst-32250	25	19	disarmed	disarm	VERB
ajst-32250	25	20	”	"	PUNCT
ajst-32250	25	21	to	to	PART
ajst-32250	25	22	prevent	prevent	VERB
ajst-32250	25	23	host	host	NOUN
ajst-32250	25	24	cell	cell	NOUN
ajst-32250	25	25	lysis	lysis	NOUN
ajst-32250	25	26	after	after	ADP
ajst-32250	25	27	delivering	deliver	VERB
ajst-32250	25	28	therapeutic	therapeutic	ADJ
ajst-32250	25	29	material	material	NOUN
ajst-32250	25	30	.	.	PUNCT
ajst-32250	26	1	in	in	ADP
ajst-32250	26	2	contrast	contrast	NOUN
ajst-32250	26	3	,	,	PUNCT
ajst-32250	26	4	their	their	PRON
ajst-32250	26	5	surfaces	surface	NOUN
ajst-32250	26	6	can	can	AUX
ajst-32250	26	7	be	be	AUX
ajst-32250	26	8	engineered	engineer	VERB
ajst-32250	26	9	with	with	ADP
ajst-32250	26	10	targeting	target	VERB
ajst-32250	26	11	ligands	ligand	NOUN
ajst-32250	26	12	to	to	PART
ajst-32250	26	13	enhance	enhance	VERB
ajst-32250	26	14	binding	bind	VERB
ajst-32250	26	15	specificity	specificity	NOUN
ajst-32250	26	16	.	.	PUNCT
ajst-32250	27	1	furthermore	furthermore	ADV
ajst-32250	27	2	,	,	PUNCT
ajst-32250	27	3	their	their	PRON
ajst-32250	27	4	capsid	capsid	NOUN
ajst-32250	27	5	structures	structure	NOUN
ajst-32250	27	6	can	can	AUX
ajst-32250	27	7	be	be	AUX
ajst-32250	27	8	designed	design	VERB
ajst-32250	27	9	to	to	PART
ajst-32250	27	10	carry	carry	VERB
ajst-32250	27	11	and	and	CCONJ
ajst-32250	27	12	protect	protect	VERB
ajst-32250	27	13	therapeutic	therapeutic	ADJ
ajst-32250	27	14	genes	gene	NOUN
ajst-32250	27	15	,	,	PUNCT
ajst-32250	27	16	enabling	enable	VERB
ajst-32250	27	17	precise	precise	ADJ
ajst-32250	27	18	delivery	delivery	NOUN
ajst-32250	27	19	into	into	ADP
ajst-32250	27	20	selected	select	VERB
ajst-32250	27	21	cell	cell	NOUN
ajst-32250	27	22	types	type	NOUN
ajst-32250	27	23	.	.	PUNCT
ajst-32250	28	1	these	these	DET
ajst-32250	28	2	modifications	modification	NOUN
ajst-32250	28	3	transform	transform	VERB
ajst-32250	28	4	bacteriophages	bacteriophage	NOUN
ajst-32250	28	5	into	into	ADP
ajst-32250	28	6	versatile	versatile	ADJ
ajst-32250	28	7	biomedical	biomedical	ADJ
ajst-32250	28	8	tools	tool	NOUN
ajst-32250	28	9	with	with	ADP
ajst-32250	28	10	potential	potential	ADJ
ajst-32250	28	11	applications	application	NOUN
ajst-32250	28	12	in	in	ADP
ajst-32250	28	13	antiviral	antiviral	ADJ
ajst-32250	28	14	therapies	therapy	NOUN
ajst-32250	28	15	,	,	PUNCT
ajst-32250	28	16	including	include	VERB
ajst-32250	28	17	hiv	hiv	PROPN
ajst-32250	28	18	treatment	treatment	NOUN
ajst-32250	28	19	.	.	PUNCT
ajst-32250	29	1	3	3	X
ajst-32250	29	2	.	.	X
ajst-32250	29	3	clinical	clinical	ADJ
ajst-32250	29	4	applications	application	NOUN
ajst-32250	29	5	of	of	ADP
ajst-32250	29	6	bacteriophages	bacteriophage	NOUN
ajst-32250	29	7	in	in	ADP
ajst-32250	29	8	hiv	hiv	PROPN
ajst-32250	29	9	therapy	therapy	NOUN
ajst-32250	29	10	3.1	3.1	NUM
ajst-32250	29	11	targeted	target	VERB
ajst-32250	29	12	gene	gene	NOUN
ajst-32250	29	13	delivery	delivery	NOUN
ajst-32250	29	14	approaches	approach	VERB
ajst-32250	29	15	targeting	target	VERB
ajst-32250	29	16	hiv	hiv	PROPN
ajst-32250	29	17	-	-	PUNCT
ajst-32250	29	18	infected	infect	VERB
ajst-32250	29	19	cells	cell	NOUN
ajst-32250	29	20	:	:	PUNCT
ajst-32250	29	21	bacteriophages	bacteriophage	NOUN
ajst-32250	29	22	can	can	AUX
ajst-32250	29	23	be	be	AUX
ajst-32250	29	24	engineered	engineer	VERB
ajst-32250	29	25	to	to	PART
ajst-32250	29	26	carry	carry	VERB
ajst-32250	29	27	genes	gene	NOUN
ajst-32250	29	28	that	that	PRON
ajst-32250	29	29	can	can	AUX
ajst-32250	29	30	interfere	interfere	VERB
ajst-32250	29	31	with	with	ADP
ajst-32250	29	32	hiv	hiv	PROPN
ajst-32250	29	33	replication	replication	NOUN
ajst-32250	29	34	.	.	PUNCT
ajst-32250	30	1	they	they	PRON
ajst-32250	30	2	can	can	AUX
ajst-32250	30	3	deliver	deliver	VERB
ajst-32250	30	4	therapeutic	therapeutic	ADJ
ajst-32250	30	5	genes	gene	NOUN
ajst-32250	30	6	into	into	ADP
ajst-32250	30	7	cells	cell	NOUN
ajst-32250	30	8	to	to	PART
ajst-32250	30	9	inhibit	inhibit	VERB
ajst-32250	30	10	viral	viral	ADJ
ajst-32250	30	11	replication	replication	NOUN
ajst-32250	30	12	or	or	CCONJ
ajst-32250	30	13	boost	boost	VERB
ajst-32250	30	14	the	the	DET
ajst-32250	30	15	immune	immune	ADJ
ajst-32250	30	16	system	system	NOUN
ajst-32250	30	17	’s	’s	PART
ajst-32250	30	18	response	response	NOUN
ajst-32250	30	19	.	.	PUNCT
ajst-32250	31	1	one	one	NUM
ajst-32250	31	2	study	study	NOUN
ajst-32250	31	3	investigated	investigate	VERB
ajst-32250	31	4	the	the	DET
ajst-32250	31	5	use	use	NOUN
ajst-32250	31	6	of	of	ADP
ajst-32250	31	7	engineered	engineer	VERB
ajst-32250	31	8	t4	t4	PROPN
ajst-32250	31	9	bacteriophages	bacteriophage	NOUN
ajst-32250	31	10	to	to	PART
ajst-32250	31	11	target	target	VERB
ajst-32250	31	12	and	and	CCONJ
ajst-32250	31	13	reactivate	reactivate	VERB
ajst-32250	31	14	the	the	DET
ajst-32250	31	15	latent	latent	NOUN
ajst-32250	31	16	hiv	hiv	PROPN
ajst-32250	31	17	reservoir	reservoir	PROPN
ajst-32250	31	18	.	.	PUNCT
ajst-32250	32	1	the	the	DET
ajst-32250	32	2	researchers	researcher	NOUN
ajst-32250	32	3	engineered	engineer	VERB
ajst-32250	32	4	the	the	DET
ajst-32250	32	5	phage	phage	NOUN
ajst-32250	32	6	surface	surface	NOUN
ajst-32250	32	7	to	to	PART
ajst-32250	32	8	display	display	VERB
ajst-32250	32	9	cd4	cd4	PROPN
ajst-32250	32	10	binding	bind	VERB
ajst-32250	32	11	ligands	ligand	NOUN
ajst-32250	32	12	,	,	PUNCT
ajst-32250	32	13	which	which	PRON
ajst-32250	32	14	allowed	allow	VERB
ajst-32250	32	15	the	the	DET
ajst-32250	32	16	phage	phage	NOUN
ajst-32250	32	17	to	to	PART
ajst-32250	32	18	bind	bind	VERB
ajst-32250	32	19	to	to	ADP
ajst-32250	32	20	and	and	CCONJ
ajst-32250	32	21	activate	activate	VERB
ajst-32250	32	22	latently	latently	ADV
ajst-32250	32	23	infected	infect	VERB
ajst-32250	32	24	t	t	NOUN
ajst-32250	32	25	cells	cell	NOUN
ajst-32250	32	26	,	,	PUNCT
ajst-32250	32	27	leading	lead	VERB
ajst-32250	32	28	to	to	ADP
ajst-32250	32	29	viral	viral	ADJ
ajst-32250	32	30	reactivation	reactivation	NOUN
ajst-32250	32	31	[	[	X
ajst-32250	32	32	5	5	NUM
ajst-32250	32	33	]	]	PUNCT
ajst-32250	32	34	.	.	PUNCT
ajst-32250	33	1	for	for	ADP
ajst-32250	33	2	example	example	NOUN
ajst-32250	33	3	,	,	PUNCT
ajst-32250	33	4	phage	phage	PROPN
ajst-32250	33	5	t4	t4	PROPN
ajst-32250	33	6	,	,	PUNCT
ajst-32250	33	7	a	a	DET
ajst-32250	33	8	double	double	ADJ
ajst-32250	33	9	-	-	PUNCT
ajst-32250	33	10	stranded	strand	VERB
ajst-32250	33	11	dna	dna	PROPN
ajst-32250	33	12	phage	phage	NOUN
ajst-32250	33	13	,	,	PUNCT
ajst-32250	33	14	is	be	AUX
ajst-32250	33	15	a	a	DET
ajst-32250	33	16	leading	lead	VERB
ajst-32250	33	17	candidate	candidate	NOUN
ajst-32250	33	18	for	for	ADP
ajst-32250	33	19	gene	gene	NOUN
ajst-32250	33	20	therapy	therapy	NOUN
ajst-32250	33	21	due	due	ADP
ajst-32250	33	22	to	to	ADP
ajst-32250	33	23	its	its	PRON
ajst-32250	33	24	large	large	ADJ
ajst-32250	33	25	size	size	NOUN
ajst-32250	33	26	,	,	PUNCT
ajst-32250	33	27	cell	cell	NOUN
ajst-32250	33	28	-	-	PUNCT
ajst-32250	33	29	targeting	target	VERB
ajst-32250	33	30	capabilities	capability	NOUN
ajst-32250	33	31	,	,	PUNCT
ajst-32250	33	32	safety	safety	NOUN
ajst-32250	33	33	,	,	PUNCT
ajst-32250	33	34	and	and	CCONJ
ajst-32250	33	35	ease	ease	NOUN
ajst-32250	33	36	of	of	ADP
ajst-32250	33	37	manufacturing	manufacturing	NOUN
ajst-32250	33	38	.	.	PUNCT
ajst-32250	34	1	it	it	PRON
ajst-32250	34	2	can	can	AUX
ajst-32250	34	3	be	be	AUX
ajst-32250	34	4	engineered	engineer	VERB
ajst-32250	34	5	to	to	PART
ajst-32250	34	6	carry	carry	VERB
ajst-32250	34	7	and	and	CCONJ
ajst-32250	34	8	deliver	deliver	VERB
ajst-32250	34	9	therapeutic	therapeutic	ADJ
ajst-32250	34	10	genes	gene	NOUN
ajst-32250	34	11	.	.	PUNCT
ajst-32250	35	1	specifically	specifically	ADV
ajst-32250	35	2	,	,	PUNCT
ajst-32250	35	3	a	a	DET
ajst-32250	35	4	120	120	NUM
ajst-32250	35	5	×	×	NOUN
ajst-32250	35	6	86	86	NUM
ajst-32250	35	7	nm	nm	ADJ
ajst-32250	35	8	phage	phage	NOUN
ajst-32250	35	9	capsid	capsid	NOUN
ajst-32250	35	10	,	,	PUNCT
ajst-32250	35	11	through	through	ADP
ajst-32250	35	12	the	the	DET
ajst-32250	35	13	nonessential	nonessential	ADJ
ajst-32250	35	14	capsid	capsid	ADJ
ajst-32250	35	15	binding	bind	VERB
ajst-32250	35	16	proteins	protein	NOUN
ajst-32250	35	17	soc	soc	NOUN
ajst-32250	35	18	and	and	CCONJ
ajst-32250	35	19	hoc	hoc	X
ajst-32250	35	20	,	,	PUNCT
ajst-32250	35	21	can	can	AUX
ajst-32250	35	22	display	display	VERB
ajst-32250	35	23	full	full	ADJ
ajst-32250	35	24	-	-	PUNCT
ajst-32250	35	25	length	length	NOUN
ajst-32250	35	26	antigens	antigen	NOUN
ajst-32250	35	27	against	against	ADP
ajst-32250	35	28	bacterial	bacterial	ADJ
ajst-32250	35	29	and	and	CCONJ
ajst-32250	35	30	viral	viral	ADJ
ajst-32250	35	31	pathogens	pathogen	NOUN
ajst-32250	35	32	.	.	PUNCT
ajst-32250	36	1	phages	phage	NOUN
ajst-32250	36	2	could	could	AUX
ajst-32250	36	3	be	be	AUX
ajst-32250	36	4	used	use	VERB
ajst-32250	36	5	as	as	ADP
ajst-32250	36	6	vectors	vector	NOUN
ajst-32250	36	7	to	to	PART
ajst-32250	36	8	deliver	deliver	VERB
ajst-32250	36	9	antiviral	antiviral	ADJ
ajst-32250	36	10	genes	gene	NOUN
ajst-32250	36	11	or	or	CCONJ
ajst-32250	36	12	crispr	crispr	ADJ
ajst-32250	36	13	/	/	SYM
ajst-32250	36	14	cas	cas	NOUN
ajst-32250	36	15	systems	system	NOUN
ajst-32250	36	16	to	to	PART
ajst-32250	36	17	edit	edit	VERB
ajst-32250	36	18	the	the	DET
ajst-32250	36	19	hiv	hiv	PROPN
ajst-32250	36	20	genome	genome	NOUN
ajst-32250	36	21	in	in	ADP
ajst-32250	36	22	infected	infected	ADJ
ajst-32250	36	23	cells	cell	NOUN
ajst-32250	36	24	.	.	PUNCT
ajst-32250	37	1	3.2	3.2	NUM
ajst-32250	37	2	crispr	crispr	ADJ
ajst-32250	37	3	/	/	SYM
ajst-32250	37	4	cas9	cas9	NOUN
ajst-32250	37	5	gene	gene	NOUN
ajst-32250	37	6	editing	edit	VERB
ajst-32250	37	7	via	via	ADP
ajst-32250	37	8	phages	phage	NOUN
ajst-32250	37	9	crispr	crispr	ADJ
ajst-32250	37	10	/	/	SYM
ajst-32250	37	11	cas9	cas9	NOUN
ajst-32250	37	12	technology	technology	NOUN
ajst-32250	37	13	represents	represent	VERB
ajst-32250	37	14	a	a	DET
ajst-32250	37	15	powerful	powerful	ADJ
ajst-32250	37	16	gene	gene	NOUN
ajst-32250	37	17	-	-	PUNCT
ajst-32250	37	18	editing	edit	VERB
ajst-32250	37	19	tool	tool	NOUN
ajst-32250	37	20	that	that	PRON
ajst-32250	37	21	can	can	AUX
ajst-32250	37	22	be	be	AUX
ajst-32250	37	23	harnessed	harness	VERB
ajst-32250	37	24	through	through	ADP
ajst-32250	37	25	bacteriophage	bacteriophage	NOUN
ajst-32250	37	26	vectors	vector	NOUN
ajst-32250	37	27	to	to	PART
ajst-32250	37	28	target	target	VERB
ajst-32250	37	29	and	and	CCONJ
ajst-32250	37	30	disrupt	disrupt	VERB
ajst-32250	37	31	hiv	hiv	PROPN
ajst-32250	37	32	genomes	genome	NOUN
ajst-32250	37	33	.	.	PUNCT
ajst-32250	38	1	the	the	DET
ajst-32250	38	2	mechanism	mechanism	NOUN
ajst-32250	38	3	begins	begin	VERB
ajst-32250	38	4	with	with	ADP
ajst-32250	38	5	targeting	target	VERB
ajst-32250	38	6	,	,	PUNCT
ajst-32250	38	7	where	where	SCONJ
ajst-32250	38	8	a	a	DET
ajst-32250	38	9	single	single	ADJ
ajst-32250	38	10	-	-	PUNCT
ajst-32250	38	11	guide	guide	NOUN
ajst-32250	38	12	rna	rna	NOUN
ajst-32250	38	13	(	(	PUNCT
ajst-32250	38	14	sgrna	sgrna	NOUN
ajst-32250	38	15	)	)	PUNCT
ajst-32250	38	16	complementary	complementary	ADJ
ajst-32250	38	17	to	to	ADP
ajst-32250	38	18	a	a	DET
ajst-32250	38	19	specific	specific	ADJ
ajst-32250	38	20	dna	dna	NOUN
ajst-32250	38	21	sequence	sequence	NOUN
ajst-32250	38	22	directs	direct	VERB
ajst-32250	38	23	the	the	DET
ajst-32250	38	24	cas9	cas9	NOUN
ajst-32250	38	25	protein	protein	NOUN
ajst-32250	38	26	to	to	ADP
ajst-32250	38	27	the	the	DET
ajst-32250	38	28	precise	precise	ADJ
ajst-32250	38	29	genomic	genomic	NOUN
ajst-32250	38	30	site	site	NOUN
ajst-32250	38	31	.	.	PUNCT
ajst-32250	39	1	once	once	ADV
ajst-32250	39	2	localized	localize	VERB
ajst-32250	39	3	,	,	PUNCT
ajst-32250	39	4	cas9	cas9	NOUN
ajst-32250	39	5	performs	perform	VERB
ajst-32250	39	6	cutting	cut	VERB
ajst-32250	39	7	,	,	PUNCT
ajst-32250	39	8	acting	act	VERB
ajst-32250	39	9	as	as	ADP
ajst-32250	39	10	molecular	molecular	ADJ
ajst-32250	39	11	scissors	scissor	NOUN
ajst-32250	39	12	to	to	PART
ajst-32250	39	13	create	create	VERB
ajst-32250	39	14	a	a	DET
ajst-32250	39	15	double	double	ADJ
ajst-32250	39	16	-	-	PUNCT
ajst-32250	39	17	stranded	strand	VERB
ajst-32250	39	18	break	break	NOUN
ajst-32250	39	19	at	at	ADP
ajst-32250	39	20	the	the	DET
ajst-32250	39	21	target	target	NOUN
ajst-32250	39	22	location	location	NOUN
ajst-32250	39	23	.	.	PUNCT
ajst-32250	40	1	following	follow	VERB
ajst-32250	40	2	this	this	PRON
ajst-32250	40	3	,	,	PUNCT
ajst-32250	40	4	the	the	DET
ajst-32250	40	5	cell	cell	NOUN
ajst-32250	40	6	’s	’s	PART
ajst-32250	40	7	endogenous	endogenous	ADJ
ajst-32250	40	8	repair	repair	NOUN
ajst-32250	40	9	pathways	pathway	NOUN
ajst-32250	40	10	are	be	AUX
ajst-32250	40	11	activated	activate	VERB
ajst-32250	40	12	.	.	PUNCT
ajst-32250	41	1	two	two	NUM
ajst-32250	41	2	main	main	ADJ
ajst-32250	41	3	mechanisms	mechanism	NOUN
ajst-32250	41	4	exist	exist	VERB
ajst-32250	41	5	:	:	PUNCT
ajst-32250	41	6	non	non	ADJ
ajst-32250	41	7	-	-	ADJ
ajst-32250	41	8	homologous	homologous	ADJ
ajst-32250	41	9	end	end	NOUN
ajst-32250	41	10	joining	join	VERB
ajst-32250	41	11	(	(	PUNCT
ajst-32250	41	12	nhej	nhej	ADJ
ajst-32250	41	13	)	)	PUNCT
ajst-32250	41	14	,	,	PUNCT
ajst-32250	41	15	which	which	PRON
ajst-32250	41	16	is	be	AUX
ajst-32250	41	17	error	error	NOUN
ajst-32250	41	18	-	-	PUNCT
ajst-32250	41	19	prone	prone	ADJ
ajst-32250	41	20	and	and	CCONJ
ajst-32250	41	21	typically	typically	ADV
ajst-32250	41	22	introduces	introduce	VERB
ajst-32250	41	23	small	small	ADJ
ajst-32250	41	24	insertions	insertion	NOUN
ajst-32250	41	25	or	or	CCONJ
ajst-32250	41	26	deletions	deletion	NOUN
ajst-32250	41	27	(	(	PUNCT
ajst-32250	41	28	indels	indel	NOUN
ajst-32250	41	29	)	)	PUNCT
ajst-32250	41	30	that	that	PRON
ajst-32250	41	31	disrupt	disrupt	VERB
ajst-32250	41	32	the	the	DET
ajst-32250	41	33	gene	gene	NOUN
ajst-32250	41	34	and	and	CCONJ
ajst-32250	41	35	effectively	effectively	ADV
ajst-32250	41	36	knock	knock	VERB
ajst-32250	41	37	it	it	PRON
ajst-32250	41	38	out	out	ADP
ajst-32250	41	39	;	;	PUNCT
ajst-32250	41	40	and	and	CCONJ
ajst-32250	41	41	homology	homology	NOUN
ajst-32250	41	42	-	-	PUNCT
ajst-32250	41	43	directed	direct	VERB
ajst-32250	41	44	repair	repair	NOUN
ajst-32250	41	45	(	(	PUNCT
ajst-32250	41	46	hdr	hdr	NOUN
ajst-32250	41	47	)	)	PUNCT
ajst-32250	41	48	,	,	PUNCT
ajst-32250	41	49	which	which	PRON
ajst-32250	41	50	uses	use	VERB
ajst-32250	41	51	a	a	DET
ajst-32250	41	52	supplied	supply	VERB
ajst-32250	41	53	dna	dna	NOUN
ajst-32250	41	54	template	template	NOUN
ajst-32250	41	55	to	to	PART
ajst-32250	41	56	correct	correct	VERB
ajst-32250	41	57	or	or	CCONJ
ajst-32250	41	58	replace	replace	VERB
ajst-32250	41	59	the	the	DET
ajst-32250	41	60	targeted	target	VERB
ajst-32250	41	61	sequence	sequence	NOUN
ajst-32250	41	62	with	with	ADP
ajst-32250	41	63	high	high	ADJ
ajst-32250	41	64	precision	precision	NOUN
ajst-32250	41	65	.	.	PUNCT
ajst-32250	42	1	through	through	ADP
ajst-32250	42	2	either	either	DET
ajst-32250	42	3	pathway	pathway	NOUN
ajst-32250	42	4	,	,	PUNCT
ajst-32250	42	5	crispr	crispr	PROPN
ajst-32250	42	6	/	/	SYM
ajst-32250	42	7	cas9	cas9	NOUN
ajst-32250	42	8	can	can	AUX
ajst-32250	42	9	ultimately	ultimately	ADV
ajst-32250	42	10	eliminate	eliminate	VERB
ajst-32250	42	11	or	or	CCONJ
ajst-32250	42	12	disable	disable	VERB
ajst-32250	42	13	pathogenic	pathogenic	ADJ
ajst-32250	42	14	genes	gene	NOUN
ajst-32250	42	15	,	,	PUNCT
ajst-32250	42	16	offering	offer	VERB
ajst-32250	42	17	a	a	DET
ajst-32250	42	18	potential	potential	ADJ
ajst-32250	42	19	route	route	NOUN
ajst-32250	42	20	to	to	ADP
ajst-32250	42	21	curing	cure	VERB
ajst-32250	42	22	or	or	CCONJ
ajst-32250	42	23	mitigating	mitigate	VERB
ajst-32250	42	24	hiv	hiv	PROPN
ajst-32250	42	25	infection	infection	NOUN
ajst-32250	42	26	.	.	PUNCT
ajst-32250	43	1	recent	recent	ADJ
ajst-32250	43	2	studies	study	NOUN
ajst-32250	43	3	highlight	highlight	VERB
ajst-32250	43	4	the	the	DET
ajst-32250	43	5	clinical	clinical	ADJ
ajst-32250	43	6	potential	potential	NOUN
ajst-32250	43	7	of	of	ADP
ajst-32250	43	8	this	this	DET
ajst-32250	43	9	strategy	strategy	NOUN
ajst-32250	43	10	.	.	PUNCT
ajst-32250	44	1	a	a	DET
ajst-32250	44	2	phase	phase	NOUN
ajst-32250	44	3	1/2	1/2	NUM
ajst-32250	44	4	clinical	clinical	ADJ
ajst-32250	44	5	trial	trial	NOUN
ajst-32250	44	6	conducted	conduct	VERB
ajst-32250	44	7	in	in	ADP
ajst-32250	44	8	2022	2022	NUM
ajst-32250	44	9	demonstrated	demonstrate	VERB
ajst-32250	44	10	the	the	DET
ajst-32250	44	11	first	first	ADJ
ajst-32250	44	12	successful	successful	ADJ
ajst-32250	44	13	use	use	NOUN
ajst-32250	44	14	of	of	ADP
ajst-32250	44	15	crispr	crispr	NOUN
ajst-32250	44	16	-	-	PUNCT
ajst-32250	44	17	based	base	VERB
ajst-32250	44	18	therapy	therapy	NOUN
ajst-32250	44	19	to	to	PART
ajst-32250	44	20	target	target	VERB
ajst-32250	44	21	and	and	CCONJ
ajst-32250	44	22	remove	remove	VERB
ajst-32250	44	23	hiv	hiv	PROPN
ajst-32250	44	24	dna	dna	PROPN
ajst-32250	44	25	in	in	ADP
ajst-32250	44	26	a	a	DET
ajst-32250	44	27	patient	patient	NOUN
ajst-32250	44	28	.	.	PUNCT
ajst-32250	45	1	in	in	ADP
ajst-32250	45	2	another	another	DET
ajst-32250	45	3	example	example	NOUN
ajst-32250	45	4	,	,	PUNCT
ajst-32250	45	5	crispr	crispr	PROPN
ajst-32250	45	6	/	/	SYM
ajst-32250	45	7	cas9	cas9	NOUN
ajst-32250	45	8	was	be	AUX
ajst-32250	45	9	applied	apply	VERB
ajst-32250	45	10	to	to	PART
ajst-32250	45	11	disrupt	disrupt	VERB
ajst-32250	45	12	the	the	DET
ajst-32250	45	13	hiv	hiv	PROPN
ajst-32250	45	14	rev	rev	ADJ
ajst-32250	45	15	-	-	ADJ
ajst-32250	45	16	encoding	encode	VERB
ajst-32250	45	17	gene	gene	NOUN
ajst-32250	45	18	—	—	PUNCT
ajst-32250	45	19	critical	critical	ADJ
ajst-32250	45	20	for	for	ADP
ajst-32250	45	21	viral	viral	ADJ
ajst-32250	45	22	replication	replication	NOUN
ajst-32250	45	23	—	—	PUNCT
ajst-32250	45	24	resulting	result	VERB
ajst-32250	45	25	in	in	ADP
ajst-32250	45	26	reduced	reduced	ADJ
ajst-32250	45	27	gene	gene	NOUN
ajst-32250	45	28	expression	expression	NOUN
ajst-32250	45	29	and	and	CCONJ
ajst-32250	45	30	lower	low	ADJ
ajst-32250	45	31	viral	viral	ADJ
ajst-32250	45	32	production	production	NOUN
ajst-32250	45	33	.	.	PUNCT
ajst-32250	46	1	together	together	ADV
ajst-32250	46	2	,	,	PUNCT
ajst-32250	46	3	these	these	DET
ajst-32250	46	4	findings	finding	NOUN
ajst-32250	46	5	suggest	suggest	VERB
ajst-32250	46	6	that	that	SCONJ
ajst-32250	46	7	phage	phage	NOUN
ajst-32250	46	8	-	-	PUNCT
ajst-32250	46	9	delivered	deliver	VERB
ajst-32250	46	10	crispr	crispr	ADJ
ajst-32250	46	11	/	/	SYM
ajst-32250	46	12	cas9	cas9	NOUN
ajst-32250	46	13	systems	system	NOUN
ajst-32250	46	14	could	could	AUX
ajst-32250	46	15	become	become	VERB
ajst-32250	46	16	an	an	DET
ajst-32250	46	17	innovative	innovative	ADJ
ajst-32250	46	18	therapeutic	therapeutic	ADJ
ajst-32250	46	19	modality	modality	NOUN
ajst-32250	46	20	,	,	PUNCT
ajst-32250	46	21	complementing	complement	VERB
ajst-32250	46	22	or	or	CCONJ
ajst-32250	46	23	even	even	ADV
ajst-32250	46	24	surpassing	surpass	VERB
ajst-32250	46	25	current	current	ADJ
ajst-32250	46	26	antiretroviral	antiretroviral	ADJ
ajst-32250	46	27	therapies	therapy	NOUN
ajst-32250	46	28	in	in	ADP
ajst-32250	46	29	controlling	control	VERB
ajst-32250	46	30	hiv	hiv	PROPN
ajst-32250	46	31	.	.	PUNCT
ajst-32250	47	1	3.3	3.3	NUM
ajst-32250	47	2	use	use	NOUN
ajst-32250	47	3	of	of	ADP
ajst-32250	47	4	bacteriophage	bacteriophage	NOUN
ajst-32250	47	5	-	-	PUNCT
ajst-32250	47	6	derived	derive	VERB
ajst-32250	47	7	enzymes	enzyme	NOUN
ajst-32250	47	8	some	some	DET
ajst-32250	47	9	phage	phage	NOUN
ajst-32250	47	10	-	-	PUNCT
ajst-32250	47	11	derived	derive	VERB
ajst-32250	47	12	enzymes	enzyme	NOUN
ajst-32250	47	13	,	,	PUNCT
ajst-32250	47	14	such	such	ADJ
ajst-32250	47	15	as	as	ADP
ajst-32250	47	16	endolysins	endolysin	NOUN
ajst-32250	47	17	,	,	PUNCT
ajst-32250	47	18	which	which	PRON
ajst-32250	47	19	usually	usually	ADV
ajst-32250	47	20	break	break	VERB
ajst-32250	47	21	down	down	ADP
ajst-32250	47	22	bacterial	bacterial	ADJ
ajst-32250	47	23	cell	cell	NOUN
ajst-32250	47	24	walls	wall	NOUN
ajst-32250	47	25	,	,	PUNCT
ajst-32250	47	26	may	may	AUX
ajst-32250	47	27	be	be	AUX
ajst-32250	47	28	used	use	VERB
ajst-32250	47	29	to	to	PART
ajst-32250	47	30	target	target	VERB
ajst-32250	47	31	and	and	CCONJ
ajst-32250	47	32	disrupt	disrupt	VERB
ajst-32250	47	33	hiv	hiv	PROPN
ajst-32250	47	34	particles	particle	NOUN
ajst-32250	47	35	.	.	PUNCT
ajst-32250	48	1	these	these	DET
ajst-32250	48	2	enzymes	enzyme	NOUN
ajst-32250	48	3	could	could	AUX
ajst-32250	48	4	be	be	AUX
ajst-32250	48	5	modified	modify	VERB
ajst-32250	48	6	to	to	PART
ajst-32250	48	7	act	act	VERB
ajst-32250	48	8	against	against	ADP
ajst-32250	48	9	the	the	DET
ajst-32250	48	10	virus	virus	NOUN
ajst-32250	48	11	's	's	PART
ajst-32250	48	12	outer	outer	ADJ
ajst-32250	48	13	coating	coating	NOUN
ajst-32250	48	14	,	,	PUNCT
ajst-32250	48	15	potentially	potentially	ADV
ajst-32250	48	16	reducing	reduce	VERB
ajst-32250	48	17	viral	viral	ADJ
ajst-32250	48	18	load	load	NOUN
ajst-32250	48	19	.	.	PUNCT
ajst-32250	49	1	bacteriophages	bacteriophage	NOUN
ajst-32250	49	2	,	,	PUNCT
ajst-32250	49	3	viruses	virus	NOUN
ajst-32250	49	4	that	that	PRON
ajst-32250	49	5	infect	infect	VERB
ajst-32250	49	6	bacteria	bacteria	NOUN
ajst-32250	49	7	,	,	PUNCT
ajst-32250	49	8	40	40	NUM
ajst-32250	49	9	utilize	utilize	VERB
ajst-32250	49	10	enzymes	enzyme	NOUN
ajst-32250	49	11	like	like	ADP
ajst-32250	49	12	peptidoglycan	peptidoglycan	ADJ
ajst-32250	49	13	hydrolases	hydrolase	NOUN
ajst-32250	49	14	(	(	PUNCT
ajst-32250	49	15	endolysins	endolysin	NOUN
ajst-32250	49	16	)	)	PUNCT
ajst-32250	49	17	and	and	CCONJ
ajst-32250	49	18	polysaccharide	polysaccharide	NOUN
ajst-32250	49	19	depolymerases	depolymerase	NOUN
ajst-32250	49	20	to	to	PART
ajst-32250	49	21	break	break	VERB
ajst-32250	49	22	down	down	ADP
ajst-32250	49	23	bacterial	bacterial	ADJ
ajst-32250	49	24	cell	cell	NOUN
ajst-32250	49	25	walls	wall	NOUN
ajst-32250	49	26	.	.	PUNCT
ajst-32250	50	1	these	these	DET
ajst-32250	50	2	enzymes	enzyme	NOUN
ajst-32250	50	3	help	help	VERB
ajst-32250	50	4	phages	phage	NOUN
ajst-32250	50	5	access	access	NOUN
ajst-32250	50	6	and	and	CCONJ
ajst-32250	50	7	infect	infect	VERB
ajst-32250	50	8	bacterial	bacterial	ADJ
ajst-32250	50	9	cells	cell	NOUN
ajst-32250	50	10	.	.	PUNCT
ajst-32250	51	1	one	one	NUM
ajst-32250	51	2	application	application	NOUN
ajst-32250	51	3	is	be	AUX
ajst-32250	51	4	to	to	PART
ajst-32250	51	5	identify	identify	AUX
ajst-32250	51	6	broadly	broadly	ADV
ajst-32250	51	7	neutralizing	neutralize	VERB
ajst-32250	51	8	antibodies	antibody	NOUN
ajst-32250	51	9	(	(	PUNCT
ajst-32250	51	10	bnabs	bnab	NOUN
ajst-32250	51	11	)	)	PUNCT
ajst-32250	51	12	against	against	ADP
ajst-32250	51	13	hiv	hiv	PROPN
ajst-32250	51	14	,	,	PUNCT
ajst-32250	51	15	which	which	PRON
ajst-32250	51	16	could	could	AUX
ajst-32250	51	17	be	be	AUX
ajst-32250	51	18	used	use	VERB
ajst-32250	51	19	in	in	ADP
ajst-32250	51	20	immunotherapy	immunotherapy	NOUN
ajst-32250	51	21	or	or	CCONJ
ajst-32250	51	22	vaccine	vaccine	NOUN
ajst-32250	51	23	development	development	NOUN
ajst-32250	51	24	.	.	PUNCT
ajst-32250	52	1	phages	phage	NOUN
ajst-32250	52	2	can	can	AUX
ajst-32250	52	3	also	also	ADV
ajst-32250	52	4	modulate	modulate	VERB
ajst-32250	52	5	the	the	DET
ajst-32250	52	6	immune	immune	ADJ
ajst-32250	52	7	system	system	NOUN
ajst-32250	52	8	by	by	ADP
ajst-32250	52	9	inducing	induce	VERB
ajst-32250	52	10	immune	immune	ADJ
ajst-32250	52	11	responses	response	NOUN
ajst-32250	52	12	that	that	PRON
ajst-32250	52	13	may	may	AUX
ajst-32250	52	14	enhance	enhance	VERB
ajst-32250	52	15	the	the	DET
ajst-32250	52	16	body	body	NOUN
ajst-32250	52	17	’s	’s	PART
ajst-32250	52	18	natural	natural	ADJ
ajst-32250	52	19	ability	ability	NOUN
ajst-32250	52	20	to	to	PART
ajst-32250	52	21	fight	fight	VERB
ajst-32250	52	22	hiv	hiv	PROPN
ajst-32250	52	23	.	.	PUNCT
ajst-32250	53	1	phage	phage	NOUN
ajst-32250	53	2	therapy	therapy	NOUN
ajst-32250	53	3	can	can	AUX
ajst-32250	53	4	stimulate	stimulate	VERB
ajst-32250	53	5	innate	innate	ADJ
ajst-32250	53	6	and	and	CCONJ
ajst-32250	53	7	adaptive	adaptive	ADJ
ajst-32250	53	8	immunity	immunity	NOUN
ajst-32250	53	9	,	,	PUNCT
ajst-32250	53	10	possibly	possibly	ADV
ajst-32250	53	11	offering	offer	VERB
ajst-32250	53	12	a	a	DET
ajst-32250	53	13	complementary	complementary	ADJ
ajst-32250	53	14	approach	approach	NOUN
ajst-32250	53	15	alongside	alongside	ADP
ajst-32250	53	16	conventional	conventional	ADJ
ajst-32250	53	17	antiretroviral	antiretroviral	ADJ
ajst-32250	53	18	treatment	treatment	NOUN
ajst-32250	53	19	(	(	PUNCT
ajst-32250	53	20	art	art	NOUN
ajst-32250	53	21	)	)	PUNCT
ajst-32250	54	1	[	[	X
ajst-32250	54	2	3	3	NUM
ajst-32250	54	3	]	]	PUNCT
ajst-32250	54	4	.	.	PUNCT
ajst-32250	55	1	3.4	3.4	NUM
ajst-32250	55	2	immunomodulatory	immunomodulatory	ADJ
ajst-32250	55	3	properties	property	NOUN
ajst-32250	55	4	of	of	ADP
ajst-32250	55	5	bacteriophages	bacteriophage	NOUN
ajst-32250	55	6	bacteriophages	bacteriophage	NOUN
ajst-32250	55	7	can	can	AUX
ajst-32250	55	8	modulate	modulate	VERB
ajst-32250	55	9	host	host	NOUN
ajst-32250	55	10	immunity	immunity	NOUN
ajst-32250	55	11	through	through	ADP
ajst-32250	55	12	multiple	multiple	ADJ
ajst-32250	55	13	mechanisms	mechanism	NOUN
ajst-32250	55	14	,	,	PUNCT
ajst-32250	55	15	beginning	begin	VERB
ajst-32250	55	16	with	with	ADP
ajst-32250	55	17	phage	phage	NOUN
ajst-32250	55	18	internalization	internalization	NOUN
ajst-32250	55	19	,	,	PUNCT
ajst-32250	55	20	where	where	SCONJ
ajst-32250	55	21	phages	phage	NOUN
ajst-32250	55	22	enter	enter	VERB
ajst-32250	55	23	host	host	NOUN
ajst-32250	55	24	cells	cell	NOUN
ajst-32250	55	25	—	—	PUNCT
ajst-32250	55	26	including	include	VERB
ajst-32250	55	27	immune	immune	ADJ
ajst-32250	55	28	cells	cell	NOUN
ajst-32250	55	29	such	such	ADJ
ajst-32250	55	30	as	as	ADP
ajst-32250	55	31	macrophages	macrophage	NOUN
ajst-32250	55	32	—	—	PUNCT
ajst-32250	55	33	and	and	CCONJ
ajst-32250	55	34	activate	activate	VERB
ajst-32250	55	35	viral	viral	ADJ
ajst-32250	55	36	recognition	recognition	NOUN
ajst-32250	55	37	receptors	receptor	NOUN
ajst-32250	55	38	,	,	PUNCT
ajst-32250	55	39	triggering	trigger	VERB
ajst-32250	55	40	downstream	downstream	ADJ
ajst-32250	55	41	immune	immune	ADJ
ajst-32250	55	42	responses	response	NOUN
ajst-32250	55	43	.	.	PUNCT
ajst-32250	56	1	following	follow	VERB
ajst-32250	56	2	internalization	internalization	NOUN
ajst-32250	56	3	,	,	PUNCT
ajst-32250	56	4	phages	phage	NOUN
ajst-32250	56	5	can	can	AUX
ajst-32250	56	6	drive	drive	VERB
ajst-32250	56	7	immune	immune	ADJ
ajst-32250	56	8	receptor	receptor	NOUN
ajst-32250	56	9	activation	activation	NOUN
ajst-32250	56	10	,	,	PUNCT
ajst-32250	56	11	particularly	particularly	ADV
ajst-32250	56	12	via	via	ADP
ajst-32250	56	13	toll	toll	NOUN
ajst-32250	56	14	-	-	PUNCT
ajst-32250	56	15	like	like	ADJ
ajst-32250	56	16	receptors	receptor	NOUN
ajst-32250	56	17	(	(	PUNCT
ajst-32250	56	18	tlrs	tlrs	NOUN
ajst-32250	56	19	)	)	PUNCT
ajst-32250	56	20	,	,	PUNCT
ajst-32250	56	21	which	which	PRON
ajst-32250	56	22	stimulate	stimulate	VERB
ajst-32250	56	23	signaling	signal	VERB
ajst-32250	56	24	cascades	cascade	NOUN
ajst-32250	56	25	and	and	CCONJ
ajst-32250	56	26	cytokine	cytokine	ADJ
ajst-32250	56	27	production	production	NOUN
ajst-32250	56	28	.	.	PUNCT
ajst-32250	57	1	this	this	PRON
ajst-32250	57	2	leads	lead	VERB
ajst-32250	57	3	to	to	ADP
ajst-32250	57	4	the	the	DET
ajst-32250	57	5	modulation	modulation	NOUN
ajst-32250	57	6	of	of	ADP
ajst-32250	57	7	cytokine	cytokine	ADJ
ajst-32250	57	8	release	release	NOUN
ajst-32250	57	9	,	,	PUNCT
ajst-32250	57	10	influencing	influence	VERB
ajst-32250	57	11	both	both	CCONJ
ajst-32250	57	12	pro	pro	ADJ
ajst-32250	57	13	-	-	ADJ
ajst-32250	57	14	inflammatory	inflammatory	ADJ
ajst-32250	57	15	mediators	mediator	NOUN
ajst-32250	57	16	(	(	PUNCT
ajst-32250	57	17	e.g.	e.g.	ADV
ajst-32250	57	18	,	,	PUNCT
ajst-32250	57	19	il-1β	il-1β	PROPN
ajst-32250	57	20	,	,	PUNCT
ajst-32250	57	21	il-6	il-6	NUM
ajst-32250	57	22	,	,	PUNCT
ajst-32250	57	23	tnf	tnf	PROPN
ajst-32250	57	24	-	-	PUNCT
ajst-32250	57	25	α	α	NOUN
ajst-32250	57	26	)	)	PUNCT
ajst-32250	57	27	and	and	CCONJ
ajst-32250	57	28	antiinflammatory	antiinflammatory	NOUN
ajst-32250	57	29	factors	factor	NOUN
ajst-32250	57	30	(	(	PUNCT
ajst-32250	57	31	e.g.	e.g.	ADV
ajst-32250	57	32	,	,	PUNCT
ajst-32250	57	33	il-10	il-10	PRON
ajst-32250	57	34	,	,	PUNCT
ajst-32250	57	35	il-1ra	il-1ra	NOUN
ajst-32250	57	36	,	,	PUNCT
ajst-32250	57	37	tgf	tgf	PROPN
ajst-32250	57	38	-	-	PUNCT
ajst-32250	57	39	β	β	NOUN
ajst-32250	57	40	)	)	PUNCT
ajst-32250	57	41	.	.	PUNCT
ajst-32250	58	1	beyond	beyond	ADP
ajst-32250	58	2	cytokines	cytokine	NOUN
ajst-32250	58	3	,	,	PUNCT
ajst-32250	58	4	phages	phage	NOUN
ajst-32250	58	5	can	can	AUX
ajst-32250	58	6	also	also	ADV
ajst-32250	58	7	impact	impact	VERB
ajst-32250	58	8	cellular	cellular	ADJ
ajst-32250	58	9	immune	immune	ADJ
ajst-32250	58	10	populations	population	NOUN
ajst-32250	58	11	.	.	PUNCT
ajst-32250	59	1	they	they	PRON
ajst-32250	59	2	can	can	AUX
ajst-32250	59	3	alter	alter	VERB
ajst-32250	59	4	the	the	DET
ajst-32250	59	5	activity	activity	NOUN
ajst-32250	59	6	of	of	ADP
ajst-32250	59	7	different	different	ADJ
ajst-32250	59	8	t	t	NOUN
ajst-32250	59	9	cell	cell	NOUN
ajst-32250	59	10	subsets	subset	NOUN
ajst-32250	59	11	,	,	PUNCT
ajst-32250	59	12	including	include	VERB
ajst-32250	59	13	th1	th1	NOUN
ajst-32250	59	14	and	and	CCONJ
ajst-32250	59	15	th17	th17	PROPN
ajst-32250	59	16	cells	cell	NOUN
ajst-32250	59	17	,	,	PUNCT
ajst-32250	59	18	and	and	CCONJ
ajst-32250	59	19	influence	influence	VERB
ajst-32250	59	20	the	the	DET
ajst-32250	59	21	functional	functional	ADJ
ajst-32250	59	22	responses	response	NOUN
ajst-32250	59	23	of	of	ADP
ajst-32250	59	24	macrophages	macrophage	NOUN
ajst-32250	59	25	and	and	CCONJ
ajst-32250	59	26	neutrophils	neutrophil	NOUN
ajst-32250	59	27	,	,	PUNCT
ajst-32250	59	28	regulating	regulate	VERB
ajst-32250	59	29	migration	migration	NOUN
ajst-32250	59	30	and	and	CCONJ
ajst-32250	59	31	the	the	DET
ajst-32250	59	32	release	release	NOUN
ajst-32250	59	33	of	of	ADP
ajst-32250	59	34	inflammatory	inflammatory	ADJ
ajst-32250	59	35	mediators	mediator	NOUN
ajst-32250	59	36	.	.	PUNCT
ajst-32250	60	1	in	in	ADP
ajst-32250	60	2	addition	addition	NOUN
ajst-32250	60	3	,	,	PUNCT
ajst-32250	60	4	phages	phage	NOUN
ajst-32250	60	5	contribute	contribute	VERB
ajst-32250	60	6	to	to	ADP
ajst-32250	60	7	immune	immune	ADJ
ajst-32250	60	8	modulation	modulation	NOUN
ajst-32250	60	9	indirectly	indirectly	ADV
ajst-32250	60	10	:	:	PUNCT
ajst-32250	60	11	through	through	ADP
ajst-32250	60	12	bacterial	bacterial	ADJ
ajst-32250	60	13	component	component	NOUN
ajst-32250	60	14	release	release	NOUN
ajst-32250	60	15	(	(	PUNCT
ajst-32250	60	16	e.g.	e.g.	ADV
ajst-32250	60	17	,	,	PUNCT
ajst-32250	60	18	lipopolysaccharide	lipopolysaccharide	ADJ
ajst-32250	60	19	during	during	ADP
ajst-32250	60	20	bacterial	bacterial	ADJ
ajst-32250	60	21	lysis	lysis	NOUN
ajst-32250	60	22	)	)	PUNCT
ajst-32250	60	23	,	,	PUNCT
ajst-32250	60	24	they	they	PRON
ajst-32250	60	25	can	can	AUX
ajst-32250	60	26	further	far	ADV
ajst-32250	60	27	stimulate	stimulate	VERB
ajst-32250	60	28	immune	immune	ADJ
ajst-32250	60	29	activation	activation	NOUN
ajst-32250	60	30	,	,	PUNCT
ajst-32250	60	31	while	while	SCONJ
ajst-32250	60	32	also	also	ADV
ajst-32250	60	33	exerting	exert	VERB
ajst-32250	60	34	effects	effect	NOUN
ajst-32250	60	35	on	on	ADP
ajst-32250	60	36	bacterial	bacterial	ADJ
ajst-32250	60	37	persistence	persistence	NOUN
ajst-32250	60	38	,	,	PUNCT
ajst-32250	60	39	sometimes	sometimes	ADV
ajst-32250	60	40	dampening	dampen	VERB
ajst-32250	60	41	inflammation	inflammation	NOUN
ajst-32250	60	42	in	in	ADP
ajst-32250	60	43	ways	way	NOUN
ajst-32250	60	44	that	that	PRON
ajst-32250	60	45	allow	allow	VERB
ajst-32250	60	46	bacteria	bacteria	NOUN
ajst-32250	60	47	to	to	PART
ajst-32250	60	48	survive	survive	VERB
ajst-32250	60	49	under	under	ADP
ajst-32250	60	50	host	host	NOUN
ajst-32250	60	51	immune	immune	ADJ
ajst-32250	60	52	pressure	pressure	NOUN
ajst-32250	60	53	.	.	PUNCT
ajst-32250	61	1	examples	example	NOUN
ajst-32250	61	2	of	of	ADP
ajst-32250	61	3	phage	phage	NOUN
ajst-32250	61	4	-	-	PUNCT
ajst-32250	61	5	mediated	mediate	VERB
ajst-32250	61	6	immunomodulation	immunomodulation	NOUN
ajst-32250	61	7	include	include	VERB
ajst-32250	61	8	using	use	VERB
ajst-32250	61	9	bacteriophage	bacteriophage	NOUN
ajst-32250	61	10	t4	t4	PROPN
ajst-32250	61	11	as	as	ADP
ajst-32250	61	12	a	a	DET
ajst-32250	61	13	vaccine	vaccine	NOUN
ajst-32250	61	14	platform	platform	NOUN
ajst-32250	61	15	.	.	PUNCT
ajst-32250	62	1	it	it	PRON
ajst-32250	62	2	can	can	AUX
ajst-32250	62	3	display	display	VERB
ajst-32250	62	4	hiv	hiv	PROPN
ajst-32250	62	5	antigens	antigen	NOUN
ajst-32250	62	6	on	on	ADP
ajst-32250	62	7	its	its	PRON
ajst-32250	62	8	capsid	capsid	NOUN
ajst-32250	62	9	and	and	CCONJ
ajst-32250	62	10	elicit	elicit	VERB
ajst-32250	62	11	robust	robust	ADJ
ajst-32250	62	12	humoral	humoral	ADJ
ajst-32250	62	13	and	and	CCONJ
ajst-32250	62	14	cellular	cellular	ADJ
ajst-32250	62	15	responses	response	NOUN
ajst-32250	62	16	in	in	ADP
ajst-32250	62	17	mice	mouse	NOUN
ajst-32250	62	18	without	without	ADP
ajst-32250	62	19	incorporating	incorporate	VERB
ajst-32250	62	20	hiv	hiv	PROPN
ajst-32250	62	21	genetic	genetic	ADJ
ajst-32250	62	22	material	material	NOUN
ajst-32250	62	23	.	.	PUNCT
ajst-32250	63	1	phages	phage	NOUN
ajst-32250	63	2	may	may	AUX
ajst-32250	63	3	also	also	ADV
ajst-32250	63	4	protect	protect	VERB
ajst-32250	63	5	against	against	ADP
ajst-32250	63	6	oxidative	oxidative	ADJ
ajst-32250	63	7	stress	stress	NOUN
ajst-32250	63	8	by	by	ADP
ajst-32250	63	9	mitigating	mitigate	VERB
ajst-32250	63	10	phagocytes	phagocyte	NOUN
ajst-32250	63	11	'	'	PART
ajst-32250	63	12	reactive	reactive	ADJ
ajst-32250	63	13	oxygen	oxygen	NOUN
ajst-32250	63	14	species	specie	NOUN
ajst-32250	63	15	(	(	PUNCT
ajst-32250	63	16	ros	ros	PROPN
ajst-32250	63	17	)	)	PUNCT
ajst-32250	63	18	damage	damage	NOUN
ajst-32250	63	19	.	.	PUNCT
ajst-32250	64	1	furthermore	furthermore	ADV
ajst-32250	64	2	,	,	PUNCT
ajst-32250	64	3	some	some	DET
ajst-32250	64	4	phages	phage	NOUN
ajst-32250	64	5	interact	interact	VERB
ajst-32250	64	6	with	with	ADP
ajst-32250	64	7	integrin	integrin	NOUN
ajst-32250	64	8	receptors	receptor	NOUN
ajst-32250	64	9	on	on	ADP
ajst-32250	64	10	mammalian	mammalian	ADJ
ajst-32250	64	11	cells	cell	NOUN
ajst-32250	64	12	,	,	PUNCT
ajst-32250	64	13	thereby	thereby	ADV
ajst-32250	64	14	influencing	influence	VERB
ajst-32250	64	15	adhesion	adhesion	NOUN
ajst-32250	64	16	,	,	PUNCT
ajst-32250	64	17	migration	migration	NOUN
ajst-32250	64	18	,	,	PUNCT
ajst-32250	64	19	and	and	CCONJ
ajst-32250	64	20	potentially	potentially	ADV
ajst-32250	64	21	processes	process	VERB
ajst-32250	64	22	such	such	ADJ
ajst-32250	64	23	as	as	ADP
ajst-32250	64	24	tumor	tumor	NOUN
ajst-32250	64	25	metastasis	metastasis	NOUN
ajst-32250	64	26	.	.	PUNCT
ajst-32250	65	1	4	4	X
ajst-32250	65	2	.	.	X
ajst-32250	65	3	synergistic	synergistic	ADJ
ajst-32250	65	4	combination	combination	NOUN
ajst-32250	65	5	with	with	ADP
ajst-32250	65	6	antiretroviral	antiretroviral	ADJ
ajst-32250	65	7	therapy	therapy	NOUN
ajst-32250	65	8	(	(	PUNCT
ajst-32250	65	9	art	art	NOUN
ajst-32250	65	10	)	)	PUNCT
ajst-32250	65	11	4.1	4.1	NUM
ajst-32250	65	12	overview	overview	NOUN
ajst-32250	65	13	of	of	ADP
ajst-32250	65	14	art	art	NOUN
ajst-32250	65	15	mechanisms	mechanism	NOUN
ajst-32250	65	16	phage	phage	NOUN
ajst-32250	65	17	-	-	PUNCT
ajst-32250	65	18	based	base	VERB
ajst-32250	65	19	therapies	therapy	NOUN
ajst-32250	65	20	could	could	AUX
ajst-32250	65	21	potentially	potentially	ADV
ajst-32250	65	22	work	work	VERB
ajst-32250	65	23	synergistically	synergistically	ADV
ajst-32250	65	24	with	with	ADP
ajst-32250	65	25	art	art	NOUN
ajst-32250	65	26	,	,	PUNCT
ajst-32250	65	27	providing	provide	VERB
ajst-32250	65	28	an	an	DET
ajst-32250	65	29	additional	additional	ADJ
ajst-32250	65	30	tool	tool	NOUN
ajst-32250	65	31	to	to	PART
ajst-32250	65	32	control	control	VERB
ajst-32250	65	33	hiv	hiv	PROPN
ajst-32250	65	34	replication	replication	NOUN
ajst-32250	65	35	and	and	CCONJ
ajst-32250	65	36	its	its	PRON
ajst-32250	65	37	reservoirs	reservoir	NOUN
ajst-32250	65	38	in	in	ADP
ajst-32250	65	39	the	the	DET
ajst-32250	65	40	body	body	NOUN
ajst-32250	65	41	.	.	PUNCT
ajst-32250	66	1	by	by	ADP
ajst-32250	66	2	combining	combine	VERB
ajst-32250	66	3	both	both	DET
ajst-32250	66	4	therapies	therapy	NOUN
ajst-32250	66	5	,	,	PUNCT
ajst-32250	66	6	it	it	PRON
ajst-32250	66	7	might	might	AUX
ajst-32250	66	8	be	be	AUX
ajst-32250	66	9	possible	possible	ADJ
ajst-32250	66	10	to	to	PART
ajst-32250	66	11	improve	improve	VERB
ajst-32250	66	12	outcomes	outcome	NOUN
ajst-32250	66	13	and	and	CCONJ
ajst-32250	66	14	reduce	reduce	VERB
ajst-32250	66	15	reliance	reliance	NOUN
ajst-32250	66	16	on	on	ADP
ajst-32250	66	17	traditional	traditional	ADJ
ajst-32250	66	18	drug	drug	NOUN
ajst-32250	66	19	regimens	regimen	NOUN
ajst-32250	66	20	.	.	PUNCT
ajst-32250	67	1	its	its	PRON
ajst-32250	67	2	mechanisms	mechanism	NOUN
ajst-32250	67	3	target	target	VERB
ajst-32250	67	4	the	the	DET
ajst-32250	67	5	life	life	NOUN
ajst-32250	67	6	cycle	cycle	NOUN
ajst-32250	67	7	by	by	ADP
ajst-32250	67	8	reverse	reverse	ADJ
ajst-32250	67	9	transcriptase	transcriptase	NOUN
ajst-32250	67	10	inhibition	inhibition	NOUN
ajst-32250	67	11	.	.	PUNCT
ajst-32250	68	1	these	these	DET
ajst-32250	68	2	drugs	drug	NOUN
ajst-32250	68	3	block	block	VERB
ajst-32250	68	4	the	the	DET
ajst-32250	68	5	reverse	reverse	ADJ
ajst-32250	68	6	transcriptase	transcriptase	NOUN
ajst-32250	68	7	enzyme	enzyme	NOUN
ajst-32250	68	8	hiv	hiv	PROPN
ajst-32250	68	9	uses	use	VERB
ajst-32250	68	10	to	to	PART
ajst-32250	68	11	convert	convert	VERB
ajst-32250	68	12	its	its	PRON
ajst-32250	68	13	rna	rna	NOUN
ajst-32250	68	14	into	into	ADP
ajst-32250	68	15	dna	dna	PROPN
ajst-32250	68	16	.	.	PUNCT
ajst-32250	69	1	protease	protease	NOUN
ajst-32250	69	2	inhibition	inhibition	NOUN
ajst-32250	69	3	also	also	ADV
ajst-32250	69	4	plays	play	VERB
ajst-32250	69	5	a	a	DET
ajst-32250	69	6	role	role	NOUN
ajst-32250	69	7	.	.	PUNCT
ajst-32250	70	1	these	these	DET
ajst-32250	70	2	drugs	drug	NOUN
ajst-32250	70	3	block	block	VERB
ajst-32250	70	4	the	the	DET
ajst-32250	70	5	protease	protease	NOUN
ajst-32250	70	6	enzyme	enzyme	NOUN
ajst-32250	70	7	,	,	PUNCT
ajst-32250	70	8	which	which	PRON
ajst-32250	70	9	hiv	hiv	PROPN
ajst-32250	70	10	needs	need	VERB
ajst-32250	70	11	to	to	PART
ajst-32250	70	12	assemble	assemble	VERB
ajst-32250	70	13	new	new	ADJ
ajst-32250	70	14	viral	viral	ADJ
ajst-32250	70	15	particles	particle	NOUN
ajst-32250	70	16	.	.	PUNCT
ajst-32250	71	1	these	these	DET
ajst-32250	71	2	drugs	drug	NOUN
ajst-32250	71	3	also	also	ADV
ajst-32250	71	4	block	block	VERB
ajst-32250	71	5	the	the	DET
ajst-32250	71	6	integrase	integrase	NOUN
ajst-32250	71	7	enzyme	enzyme	NOUN
ajst-32250	71	8	hiv	hiv	PROPN
ajst-32250	71	9	uses	use	VERB
ajst-32250	71	10	to	to	PART
ajst-32250	71	11	integrate	integrate	VERB
ajst-32250	71	12	its	its	PRON
ajst-32250	71	13	dna	dna	NOUN
ajst-32250	71	14	into	into	ADP
ajst-32250	71	15	the	the	DET
ajst-32250	71	16	host	host	NOUN
ajst-32250	71	17	cell	cell	NOUN
ajst-32250	71	18	's	's	PART
ajst-32250	71	19	dna	dna	NOUN
ajst-32250	71	20	and	and	CCONJ
ajst-32250	71	21	prevent	prevent	VERB
ajst-32250	71	22	hiv	hiv	PROPN
ajst-32250	71	23	from	from	ADP
ajst-32250	71	24	entering	enter	VERB
ajst-32250	71	25	and	and	CCONJ
ajst-32250	71	26	infecting	infect	VERB
ajst-32250	71	27	new	new	ADJ
ajst-32250	71	28	cells	cell	NOUN
ajst-32250	71	29	.	.	PUNCT
ajst-32250	72	1	4.2	4.2	NUM
ajst-32250	72	2	potential	potential	ADJ
ajst-32250	72	3	synergy	synergy	NOUN
ajst-32250	72	4	between	between	ADP
ajst-32250	72	5	phage	phage	NOUN
ajst-32250	72	6	therapy	therapy	NOUN
ajst-32250	72	7	and	and	CCONJ
ajst-32250	72	8	art	art	NOUN
ajst-32250	72	9	by	by	ADP
ajst-32250	72	10	targeting	target	VERB
ajst-32250	72	11	different	different	ADJ
ajst-32250	72	12	stages	stage	NOUN
ajst-32250	72	13	of	of	ADP
ajst-32250	72	14	the	the	DET
ajst-32250	72	15	viral	viral	ADJ
ajst-32250	72	16	life	life	NOUN
ajst-32250	72	17	cycle	cycle	NOUN
ajst-32250	72	18	,	,	PUNCT
ajst-32250	72	19	art	art	NOUN
ajst-32250	72	20	medications	medication	NOUN
ajst-32250	72	21	significantly	significantly	ADV
ajst-32250	72	22	reduce	reduce	VERB
ajst-32250	72	23	the	the	DET
ajst-32250	72	24	amount	amount	NOUN
ajst-32250	72	25	of	of	ADP
ajst-32250	72	26	hiv	hiv	PROPN
ajst-32250	72	27	in	in	ADP
ajst-32250	72	28	the	the	DET
ajst-32250	72	29	body	body	NOUN
ajst-32250	72	30	(	(	PUNCT
ajst-32250	72	31	viral	viral	ADJ
ajst-32250	72	32	load	load	NOUN
ajst-32250	72	33	)	)	PUNCT
ajst-32250	72	34	.	.	PUNCT
ajst-32250	73	1	also	also	ADV
ajst-32250	73	2	,	,	PUNCT
ajst-32250	73	3	using	use	VERB
ajst-32250	73	4	multiple	multiple	ADJ
ajst-32250	73	5	drugs	drug	NOUN
ajst-32250	73	6	with	with	ADP
ajst-32250	73	7	different	different	ADJ
ajst-32250	73	8	mechanisms	mechanism	NOUN
ajst-32250	73	9	of	of	ADP
ajst-32250	73	10	action	action	NOUN
ajst-32250	73	11	makes	make	VERB
ajst-32250	73	12	it	it	PRON
ajst-32250	73	13	harder	hard	ADJ
ajst-32250	73	14	for	for	SCONJ
ajst-32250	73	15	the	the	DET
ajst-32250	73	16	virus	virus	NOUN
ajst-32250	73	17	to	to	PART
ajst-32250	73	18	mutate	mutate	VERB
ajst-32250	73	19	and	and	CCONJ
ajst-32250	73	20	develop	develop	VERB
ajst-32250	73	21	resistance	resistance	NOUN
ajst-32250	73	22	to	to	ADP
ajst-32250	73	23	the	the	DET
ajst-32250	73	24	treatment	treatment	NOUN
ajst-32250	73	25	.	.	PUNCT
ajst-32250	74	1	by	by	ADP
ajst-32250	74	2	suppressing	suppress	VERB
ajst-32250	74	3	the	the	DET
ajst-32250	74	4	virus	virus	NOUN
ajst-32250	74	5	,	,	PUNCT
ajst-32250	74	6	art	art	NOUN
ajst-32250	74	7	helps	help	VERB
ajst-32250	74	8	to	to	PART
ajst-32250	74	9	protect	protect	VERB
ajst-32250	74	10	and	and	CCONJ
ajst-32250	74	11	preserve	preserve	VERB
ajst-32250	74	12	the	the	DET
ajst-32250	74	13	cd4	cd4	PROPN
ajst-32250	74	14	+	+	PROPN
ajst-32250	74	15	t	t	NOUN
ajst-32250	74	16	cells	cell	NOUN
ajst-32250	74	17	,	,	PUNCT
ajst-32250	74	18	which	which	PRON
ajst-32250	74	19	are	be	AUX
ajst-32250	74	20	crucial	crucial	ADJ
ajst-32250	74	21	for	for	ADP
ajst-32250	74	22	a	a	DET
ajst-32250	74	23	healthy	healthy	ADJ
ajst-32250	74	24	immune	immune	ADJ
ajst-32250	74	25	system	system	NOUN
ajst-32250	74	26	.	.	PUNCT
ajst-32250	75	1	when	when	SCONJ
ajst-32250	75	2	the	the	DET
ajst-32250	75	3	viral	viral	ADJ
ajst-32250	75	4	load	load	NOUN
ajst-32250	75	5	is	be	AUX
ajst-32250	75	6	suppressed	suppress	VERB
ajst-32250	75	7	to	to	ADP
ajst-32250	75	8	undetectable	undetectable	ADJ
ajst-32250	75	9	levels	level	NOUN
ajst-32250	75	10	,	,	PUNCT
ajst-32250	75	11	the	the	DET
ajst-32250	75	12	amount	amount	NOUN
ajst-32250	75	13	of	of	ADP
ajst-32250	75	14	virus	virus	NOUN
ajst-32250	75	15	in	in	ADP
ajst-32250	75	16	the	the	DET
ajst-32250	75	17	blood	blood	NOUN
ajst-32250	75	18	is	be	AUX
ajst-32250	75	19	so	so	ADV
ajst-32250	75	20	low	low	ADJ
ajst-32250	75	21	that	that	SCONJ
ajst-32250	75	22	standard	standard	ADJ
ajst-32250	75	23	tests	test	NOUN
ajst-32250	75	24	can	can	AUX
ajst-32250	75	25	not	not	PART
ajst-32250	75	26	detect	detect	VERB
ajst-32250	75	27	it	it	PRON
ajst-32250	75	28	.	.	PUNCT
ajst-32250	76	1	this	this	PRON
ajst-32250	76	2	is	be	AUX
ajst-32250	76	3	a	a	DET
ajst-32250	76	4	significant	significant	ADJ
ajst-32250	76	5	goal	goal	NOUN
ajst-32250	76	6	of	of	ADP
ajst-32250	76	7	art	art	NOUN
ajst-32250	76	8	,	,	PUNCT
ajst-32250	76	9	as	as	SCONJ
ajst-32250	76	10	it	it	PRON
ajst-32250	76	11	indicates	indicate	VERB
ajst-32250	76	12	that	that	SCONJ
ajst-32250	76	13	the	the	DET
ajst-32250	76	14	treatment	treatment	NOUN
ajst-32250	76	15	works	work	VERB
ajst-32250	76	16	effectively	effectively	ADV
ajst-32250	76	17	and	and	CCONJ
ajst-32250	76	18	reduces	reduce	VERB
ajst-32250	76	19	the	the	DET
ajst-32250	76	20	risk	risk	NOUN
ajst-32250	76	21	of	of	ADP
ajst-32250	76	22	transmission	transmission	NOUN
ajst-32250	76	23	.	.	PUNCT
ajst-32250	77	1	while	while	SCONJ
ajst-32250	77	2	art	art	NOUN
ajst-32250	77	3	can	can	AUX
ajst-32250	77	4	effectively	effectively	ADV
ajst-32250	77	5	suppress	suppress	VERB
ajst-32250	77	6	hiv	hiv	PROPN
ajst-32250	77	7	,	,	PUNCT
ajst-32250	77	8	it	it	PRON
ajst-32250	77	9	41	41	NUM
ajst-32250	77	10	does	do	AUX
ajst-32250	77	11	n't	not	PART
ajst-32250	77	12	eliminate	eliminate	VERB
ajst-32250	77	13	it	it	PRON
ajst-32250	77	14	from	from	ADP
ajst-32250	77	15	the	the	DET
ajst-32250	77	16	body	body	NOUN
ajst-32250	77	17	.	.	PUNCT
ajst-32250	78	1	hiv	hiv	PROPN
ajst-32250	78	2	can	can	AUX
ajst-32250	78	3	remain	remain	VERB
ajst-32250	78	4	in	in	ADP
ajst-32250	78	5	reservoirs	reservoir	NOUN
ajst-32250	78	6	of	of	ADP
ajst-32250	78	7	infected	infected	ADJ
ajst-32250	78	8	cells	cell	NOUN
ajst-32250	78	9	,	,	PUNCT
ajst-32250	78	10	but	but	CCONJ
ajst-32250	78	11	with	with	ADP
ajst-32250	78	12	art	art	NOUN
ajst-32250	78	13	,	,	PUNCT
ajst-32250	78	14	these	these	DET
ajst-32250	78	15	reservoirs	reservoir	NOUN
ajst-32250	78	16	are	be	AUX
ajst-32250	78	17	kept	keep	VERB
ajst-32250	78	18	under	under	ADP
ajst-32250	78	19	control	control	NOUN
ajst-32250	78	20	.	.	PUNCT
ajst-32250	79	1	4.3	4.3	NUM
ajst-32250	79	2	examples	example	NOUN
ajst-32250	79	3	of	of	ADP
ajst-32250	79	4	combination	combination	NOUN
ajst-32250	79	5	therapies	therapy	NOUN
ajst-32250	79	6	combination	combination	VERB
ajst-32250	79	7	antiretroviral	antiretroviral	ADJ
ajst-32250	79	8	therapy	therapy	NOUN
ajst-32250	79	9	(	(	PUNCT
ajst-32250	79	10	art	art	NOUN
ajst-32250	79	11	)	)	PUNCT
ajst-32250	79	12	is	be	AUX
ajst-32250	79	13	administered	administer	VERB
ajst-32250	79	14	either	either	CCONJ
ajst-32250	79	15	as	as	ADP
ajst-32250	79	16	fixed	fix	VERB
ajst-32250	79	17	-	-	PUNCT
ajst-32250	79	18	dose	dose	ADJ
ajst-32250	79	19	single	single	ADJ
ajst-32250	79	20	tablets	tablet	NOUN
ajst-32250	79	21	or	or	CCONJ
ajst-32250	79	22	as	as	ADP
ajst-32250	79	23	multi	multi	ADJ
ajst-32250	79	24	-	-	ADJ
ajst-32250	79	25	pill	pill	NOUN
ajst-32250	79	26	regimens	regimen	NOUN
ajst-32250	79	27	,	,	PUNCT
ajst-32250	79	28	both	both	PRON
ajst-32250	79	29	aim	aim	VERB
ajst-32250	79	30	to	to	PART
ajst-32250	79	31	simplify	simplify	VERB
ajst-32250	79	32	adherence	adherence	NOUN
ajst-32250	79	33	while	while	SCONJ
ajst-32250	79	34	maximizing	maximize	VERB
ajst-32250	79	35	viral	viral	ADJ
ajst-32250	79	36	suppression	suppression	NOUN
ajst-32250	79	37	.	.	PUNCT
ajst-32250	80	1	widely	widely	ADV
ajst-32250	80	2	used	use	VERB
ajst-32250	80	3	fixed	fix	VERB
ajst-32250	80	4	-	-	PUNCT
ajst-32250	80	5	dose	dose	NOUN
ajst-32250	80	6	combinations	combination	NOUN
ajst-32250	80	7	include	include	VERB
ajst-32250	80	8	biktarvy	biktarvy	PROPN
ajst-32250	80	9	(	(	PUNCT
ajst-32250	80	10	bictegravir	bictegravir	PROPN
ajst-32250	80	11	/	/	SYM
ajst-32250	80	12	emtricitabine	emtricitabine	PROPN
ajst-32250	80	13	/	/	SYM
ajst-32250	80	14	tenofovir	tenofovir	PROPN
ajst-32250	80	15	alafenamide	alafenamide	PROPN
ajst-32250	80	16	)	)	PUNCT
ajst-32250	80	17	,	,	PUNCT
ajst-32250	80	18	triumeq	triumeq	NOUN
ajst-32250	80	19	(	(	PUNCT
ajst-32250	80	20	dolutegravir	dolutegravir	PROPN
ajst-32250	80	21	/	/	SYM
ajst-32250	80	22	abacavir	abacavir	PROPN
ajst-32250	80	23	/	/	SYM
ajst-32250	80	24	lamivudine	lamivudine	NOUN
ajst-32250	80	25	)	)	PUNCT
ajst-32250	80	26	,	,	PUNCT
ajst-32250	80	27	dovato	dovato	NOUN
ajst-32250	80	28	(	(	PUNCT
ajst-32250	80	29	dolutegravir	dolutegravir	PROPN
ajst-32250	80	30	/	/	SYM
ajst-32250	80	31	lamivudine	lamivudine	NOUN
ajst-32250	80	32	)	)	PUNCT
ajst-32250	80	33	,	,	PUNCT
ajst-32250	80	34	genvoya	genvoya	NOUN
ajst-32250	80	35	(	(	PUNCT
ajst-32250	80	36	elvitegravir/	elvitegravir/	NUM
ajst-32250	80	37	cobicistat	cobicistat	NOUN
ajst-32250	80	38	/	/	SYM
ajst-32250	80	39	emtricitabine	emtricitabine	NOUN
ajst-32250	80	40	/	/	SYM
ajst-32250	80	41	tenofovir	tenofovir	PROPN
ajst-32250	80	42	alafenamide	alafenamide	PROPN
ajst-32250	80	43	)	)	PUNCT
ajst-32250	80	44	,	,	PUNCT
ajst-32250	80	45	and	and	CCONJ
ajst-32250	80	46	stribild	stribild	VERB
ajst-32250	80	47	(	(	PUNCT
ajst-32250	80	48	elvitegravir/	elvitegravir/	NUM
ajst-32250	80	49	cobicistat/	cobicistat/	NUM
ajst-32250	80	50	emtricitabine	emtricitabine	NOUN
ajst-32250	80	51	/	/	SYM
ajst-32250	80	52	tenofovir	tenofovir	PROPN
ajst-32250	80	53	disoproxil	disoproxil	VERB
ajst-32250	80	54	fumarate	fumarate	NOUN
ajst-32250	80	55	)	)	PUNCT
ajst-32250	80	56	.	.	PUNCT
ajst-32250	81	1	commonly	commonly	ADV
ajst-32250	81	2	prescribed	prescribe	VERB
ajst-32250	81	3	multi	multi	ADJ
ajst-32250	81	4	-	-	ADJ
ajst-32250	81	5	pill	pill	NOUN
ajst-32250	81	6	regimens	regimen	NOUN
ajst-32250	81	7	include	include	VERB
ajst-32250	81	8	dolutegravir	dolutegravir	NOUN
ajst-32250	81	9	with	with	ADP
ajst-32250	81	10	abacavir	abacavir	NOUN
ajst-32250	81	11	and	and	CCONJ
ajst-32250	81	12	lamivudine	lamivudine	PROPN
ajst-32250	81	13	,	,	PUNCT
ajst-32250	81	14	dolutegravir	dolutegravir	NOUN
ajst-32250	81	15	with	with	ADP
ajst-32250	81	16	tenofovir	tenofovir	NOUN
ajst-32250	81	17	and	and	CCONJ
ajst-32250	81	18	emtricitabine	emtricitabine	PROPN
ajst-32250	81	19	,	,	PUNCT
ajst-32250	81	20	elvitegravir	elvitegravir	PROPN
ajst-32250	81	21	with	with	ADP
ajst-32250	81	22	cobicistat	cobicistat	NOUN
ajst-32250	81	23	and	and	CCONJ
ajst-32250	81	24	tenofovir	tenofovir	NOUN
ajst-32250	81	25	plus	plus	CCONJ
ajst-32250	81	26	emtricitabine	emtricitabine	PROPN
ajst-32250	81	27	,	,	PUNCT
ajst-32250	81	28	raltegravir	raltegravir	PROPN
ajst-32250	81	29	with	with	ADP
ajst-32250	81	30	tenofovir	tenofovir	NOUN
ajst-32250	81	31	and	and	CCONJ
ajst-32250	81	32	emtricitabine	emtricitabine	NOUN
ajst-32250	81	33	,	,	PUNCT
ajst-32250	81	34	and	and	CCONJ
ajst-32250	81	35	darunavir	darunavir	ADV
ajst-32250	81	36	with	with	ADP
ajst-32250	81	37	cobicistat	cobicistat	NOUN
ajst-32250	81	38	and	and	CCONJ
ajst-32250	81	39	tenofovir	tenofovir	NOUN
ajst-32250	81	40	plus	plus	CCONJ
ajst-32250	81	41	emtricitabine	emtricitabine	NOUN
ajst-32250	81	42	.	.	PUNCT
ajst-32250	82	1	many	many	ADJ
ajst-32250	82	2	of	of	ADP
ajst-32250	82	3	these	these	DET
ajst-32250	82	4	regimens	regimen	NOUN
ajst-32250	82	5	incorporate	incorporate	VERB
ajst-32250	82	6	pharmacokinetic	pharmacokinetic	ADJ
ajst-32250	82	7	(	(	PUNCT
ajst-32250	82	8	pk	pk	NOUN
ajst-32250	82	9	)	)	PUNCT
ajst-32250	82	10	enhancers	enhancer	NOUN
ajst-32250	82	11	such	such	ADJ
ajst-32250	82	12	as	as	ADP
ajst-32250	82	13	ritonavir	ritonavir	PROPN
ajst-32250	82	14	or	or	CCONJ
ajst-32250	82	15	cobicistat	cobicistat	NOUN
ajst-32250	82	16	,	,	PUNCT
ajst-32250	82	17	inhibiting	inhibit	VERB
ajst-32250	82	18	the	the	DET
ajst-32250	82	19	hepatic	hepatic	ADJ
ajst-32250	82	20	cytochrome	cytochrome	NOUN
ajst-32250	82	21	p450	p450	NUM
ajst-32250	82	22	3a4	3a4	NUM
ajst-32250	82	23	(	(	PUNCT
ajst-32250	82	24	cyp3a4	cyp3a4	NOUN
ajst-32250	82	25	)	)	PUNCT
ajst-32250	82	26	enzyme	enzyme	NOUN
ajst-32250	82	27	.	.	PUNCT
ajst-32250	83	1	this	this	PRON
ajst-32250	83	2	reduces	reduce	VERB
ajst-32250	83	3	drug	drug	NOUN
ajst-32250	83	4	metabolism	metabolism	NOUN
ajst-32250	83	5	,	,	PUNCT
ajst-32250	83	6	thereby	thereby	ADV
ajst-32250	83	7	sustaining	sustain	VERB
ajst-32250	83	8	higher	high	ADJ
ajst-32250	83	9	systemic	systemic	ADJ
ajst-32250	83	10	concentrations	concentration	NOUN
ajst-32250	83	11	of	of	ADP
ajst-32250	83	12	active	active	ADJ
ajst-32250	83	13	agents	agent	NOUN
ajst-32250	83	14	,	,	PUNCT
ajst-32250	83	15	improving	improve	VERB
ajst-32250	83	16	therapeutic	therapeutic	ADJ
ajst-32250	83	17	efficacy	efficacy	NOUN
ajst-32250	83	18	,	,	PUNCT
ajst-32250	83	19	and	and	CCONJ
ajst-32250	83	20	reducing	reduce	VERB
ajst-32250	83	21	the	the	DET
ajst-32250	83	22	risk	risk	NOUN
ajst-32250	83	23	of	of	ADP
ajst-32250	83	24	viral	viral	ADJ
ajst-32250	83	25	resistance	resistance	NOUN
ajst-32250	83	26	.	.	PUNCT
ajst-32250	84	1	by	by	ADP
ajst-32250	84	2	combining	combine	VERB
ajst-32250	84	3	antiretroviral	antiretroviral	ADJ
ajst-32250	84	4	agents	agent	NOUN
ajst-32250	84	5	with	with	ADP
ajst-32250	84	6	distinct	distinct	ADJ
ajst-32250	84	7	mechanisms	mechanism	NOUN
ajst-32250	84	8	of	of	ADP
ajst-32250	84	9	action	action	NOUN
ajst-32250	84	10	—	—	PUNCT
ajst-32250	84	11	often	often	ADV
ajst-32250	84	12	boosted	boost	VERB
ajst-32250	84	13	by	by	ADP
ajst-32250	84	14	pk	pk	NOUN
ajst-32250	84	15	enhancers	enhancer	NOUN
ajst-32250	84	16	—	—	PUNCT
ajst-32250	84	17	these	these	DET
ajst-32250	84	18	regimens	regimen	NOUN
ajst-32250	84	19	ensure	ensure	VERB
ajst-32250	84	20	long	long	ADJ
ajst-32250	84	21	-	-	PUNCT
ajst-32250	84	22	term	term	NOUN
ajst-32250	84	23	viral	viral	ADJ
ajst-32250	84	24	suppression	suppression	NOUN
ajst-32250	84	25	,	,	PUNCT
ajst-32250	84	26	preservation	preservation	NOUN
ajst-32250	84	27	of	of	ADP
ajst-32250	84	28	immune	immune	ADJ
ajst-32250	84	29	function	function	NOUN
ajst-32250	84	30	,	,	PUNCT
ajst-32250	84	31	and	and	CCONJ
ajst-32250	84	32	reduced	reduce	VERB
ajst-32250	84	33	risk	risk	NOUN
ajst-32250	84	34	of	of	ADP
ajst-32250	84	35	treatment	treatment	NOUN
ajst-32250	84	36	failure	failure	NOUN
ajst-32250	84	37	.	.	PUNCT
ajst-32250	85	1	table	table	NOUN
ajst-32250	85	2	1	1	NUM
ajst-32250	85	3	.	.	PUNCT
ajst-32250	85	4	combination	combination	NOUN
ajst-32250	85	5	therapies	therapy	NOUN
ajst-32250	85	6	therapy	therapy	NOUN
ajst-32250	85	7	type	type	NOUN
ajst-32250	85	8	examples	example	NOUN
ajst-32250	85	9	key	key	ADJ
ajst-32250	85	10	features	feature	VERB
ajst-32250	85	11	fixed	fix	VERB
ajst-32250	85	12	-	-	PUNCT
ajst-32250	85	13	dose	dose	NOUN
ajst-32250	85	14	combinations	combination	NOUN
ajst-32250	85	15	biktarvy	biktarvy	PROPN
ajst-32250	85	16	,	,	PUNCT
ajst-32250	85	17	triumeq	triumeq	NOUN
ajst-32250	85	18	,	,	PUNCT
ajst-32250	85	19	dovato	dovato	NOUN
ajst-32250	85	20	,	,	PUNCT
ajst-32250	85	21	genvoya	genvoya	NOUN
ajst-32250	85	22	,	,	PUNCT
ajst-32250	85	23	stribild	stribild	ADJ
ajst-32250	85	24	single	single	ADJ
ajst-32250	85	25	-	-	PUNCT
ajst-32250	85	26	tablet	tablet	NOUN
ajst-32250	85	27	regimens	regimen	NOUN
ajst-32250	85	28	;	;	PUNCT
ajst-32250	85	29	improve	improve	VERB
ajst-32250	85	30	adherence	adherence	NOUN
ajst-32250	85	31	multi	multi	ADJ
ajst-32250	85	32	-	-	ADJ
ajst-32250	85	33	pill	pill	NOUN
ajst-32250	85	34	regimens	regimen	NOUN
ajst-32250	85	35	dolutegravir	dolutegravir	NOUN
ajst-32250	85	36	+	+	CCONJ
ajst-32250	85	37	abacavir	abacavir	PROPN
ajst-32250	85	38	+	+	CCONJ
ajst-32250	85	39	lamivudine	lamivudine	NOUN
ajst-32250	85	40	;	;	PUNCT
ajst-32250	85	41	raltegravir	raltegravir	NOUN
ajst-32250	85	42	+	+	CCONJ
ajst-32250	85	43	tenofovir	tenofovir	NOUN
ajst-32250	85	44	+	+	CCONJ
ajst-32250	85	45	emtricitabine	emtricitabine	NOUN
ajst-32250	85	46	;	;	PUNCT
ajst-32250	85	47	darunavir	darunavir	PROPN
ajst-32250	85	48	+	+	CCONJ
ajst-32250	85	49	cobicistat	cobicistat	NOUN
ajst-32250	85	50	+	+	CCONJ
ajst-32250	85	51	tenofovir	tenofovir	NOUN
ajst-32250	85	52	+	+	CCONJ
ajst-32250	85	53	emtricitabine	emtricitabine	PROPN
ajst-32250	85	54	flexible	flexible	ADJ
ajst-32250	85	55	combinations	combination	NOUN
ajst-32250	85	56	;	;	PUNCT
ajst-32250	85	57	widely	widely	ADV
ajst-32250	85	58	used	use	VERB
ajst-32250	85	59	in	in	ADP
ajst-32250	85	60	clinical	clinical	ADJ
ajst-32250	85	61	practice	practice	NOUN
ajst-32250	85	62	pk	pk	NOUN
ajst-32250	85	63	enhancers	enhancer	NOUN
ajst-32250	85	64	ritonavir	ritonavir	PROPN
ajst-32250	85	65	,	,	PUNCT
ajst-32250	85	66	cobicistat	cobicistat	PROPN
ajst-32250	85	67	inhibit	inhibit	NOUN
ajst-32250	85	68	cyp3a4	cyp3a4	NOUN
ajst-32250	85	69	,	,	PUNCT
ajst-32250	85	70	reduce	reduce	VERB
ajst-32250	85	71	drug	drug	NOUN
ajst-32250	85	72	metabolism	metabolism	NOUN
ajst-32250	85	73	,	,	PUNCT
ajst-32250	85	74	increase	increase	VERB
ajst-32250	85	75	plasma	plasma	NOUN
ajst-32250	85	76	drug	drug	NOUN
ajst-32250	85	77	levels	level	NOUN
ajst-32250	85	78	this	this	DET
ajst-32250	85	79	increase	increase	NOUN
ajst-32250	85	80	in	in	ADP
ajst-32250	85	81	drug	drug	NOUN
ajst-32250	85	82	levels	level	NOUN
ajst-32250	85	83	enhances	enhance	VERB
ajst-32250	85	84	the	the	DET
ajst-32250	85	85	antiviral	antiviral	ADJ
ajst-32250	85	86	activity	activity	NOUN
ajst-32250	85	87	of	of	ADP
ajst-32250	85	88	the	the	DET
ajst-32250	85	89	other	other	ADJ
ajst-32250	85	90	medications	medication	NOUN
ajst-32250	85	91	,	,	PUNCT
ajst-32250	85	92	making	make	VERB
ajst-32250	85	93	them	they	PRON
ajst-32250	85	94	more	more	ADV
ajst-32250	85	95	effective	effective	ADJ
ajst-32250	85	96	at	at	ADP
ajst-32250	85	97	suppressing	suppress	VERB
ajst-32250	85	98	hiv	hiv	PROPN
ajst-32250	85	99	replication	replication	NOUN
ajst-32250	85	100	.	.	PUNCT
ajst-32250	86	1	5	5	X
ajst-32250	86	2	.	.	NUM
ajst-32250	86	3	limitations	limitation	NOUN
ajst-32250	86	4	and	and	CCONJ
ajst-32250	86	5	future	future	ADJ
ajst-32250	86	6	directions	direction	NOUN
ajst-32250	86	7	security	security	NOUN
ajst-32250	86	8	issues	issue	NOUN
ajst-32250	86	9	and	and	CCONJ
ajst-32250	86	10	potential	potential	ADJ
ajst-32250	86	11	off	off	ADP
ajst-32250	86	12	-	-	PUNCT
ajst-32250	86	13	target	target	NOUN
ajst-32250	86	14	problems	problem	NOUN
ajst-32250	86	15	:	:	PUNCT
ajst-32250	86	16	bacteria	bacteria	NOUN
ajst-32250	86	17	can	can	AUX
ajst-32250	86	18	evolve	evolve	VERB
ajst-32250	86	19	to	to	PART
ajst-32250	86	20	become	become	VERB
ajst-32250	86	21	resistant	resistant	ADJ
ajst-32250	86	22	to	to	ADP
ajst-32250	86	23	phage	phage	NOUN
ajst-32250	86	24	attacks	attack	NOUN
ajst-32250	86	25	,	,	PUNCT
ajst-32250	86	26	a	a	DET
ajst-32250	86	27	challenge	challenge	NOUN
ajst-32250	86	28	similar	similar	ADJ
ajst-32250	86	29	to	to	ADP
ajst-32250	86	30	antibiotic	antibiotic	ADJ
ajst-32250	86	31	resistance	resistance	NOUN
ajst-32250	86	32	,	,	PUNCT
ajst-32250	86	33	potentially	potentially	ADV
ajst-32250	86	34	diminishing	diminish	VERB
ajst-32250	86	35	the	the	DET
ajst-32250	86	36	effectiveness	effectiveness	NOUN
ajst-32250	86	37	of	of	ADP
ajst-32250	86	38	phage	phage	NOUN
ajst-32250	86	39	therapy	therapy	NOUN
ajst-32250	86	40	.	.	PUNCT
ajst-32250	87	1	some	some	DET
ajst-32250	87	2	phages	phage	NOUN
ajst-32250	87	3	,	,	PUNCT
ajst-32250	87	4	particularly	particularly	ADV
ajst-32250	87	5	lysogenic	lysogenic	ADJ
ajst-32250	87	6	phages	phage	NOUN
ajst-32250	87	7	,	,	PUNCT
ajst-32250	87	8	can	can	AUX
ajst-32250	87	9	transfer	transfer	VERB
ajst-32250	87	10	genes	gene	NOUN
ajst-32250	87	11	from	from	ADP
ajst-32250	87	12	one	one	NUM
ajst-32250	87	13	bacterium	bacterium	NOUN
ajst-32250	87	14	to	to	ADP
ajst-32250	87	15	another	another	PRON
ajst-32250	87	16	,	,	PUNCT
ajst-32250	87	17	which	which	PRON
ajst-32250	87	18	could	could	AUX
ajst-32250	87	19	include	include	VERB
ajst-32250	87	20	antibiotic	antibiotic	ADJ
ajst-32250	87	21	resistance	resistance	NOUN
ajst-32250	87	22	genes	gene	NOUN
ajst-32250	87	23	,	,	PUNCT
ajst-32250	87	24	making	make	VERB
ajst-32250	87	25	bacteria	bacteria	NOUN
ajst-32250	87	26	more	more	ADV
ajst-32250	87	27	problematic	problematic	ADJ
ajst-32250	87	28	.	.	PUNCT
ajst-32250	88	1	moreover	moreover	ADV
ajst-32250	88	2	,	,	PUNCT
ajst-32250	88	3	the	the	DET
ajst-32250	88	4	immune	immune	ADJ
ajst-32250	88	5	response	response	NOUN
ajst-32250	88	6	to	to	ADP
ajst-32250	88	7	phage	phage	NOUN
ajst-32250	88	8	is	be	AUX
ajst-32250	88	9	also	also	ADV
ajst-32250	88	10	a	a	DET
ajst-32250	88	11	concern	concern	NOUN
ajst-32250	88	12	.	.	PUNCT
ajst-32250	89	1	the	the	DET
ajst-32250	89	2	host	host	NOUN
ajst-32250	89	3	's	's	PART
ajst-32250	89	4	immune	immune	ADJ
ajst-32250	89	5	system	system	NOUN
ajst-32250	89	6	can	can	AUX
ajst-32250	89	7	also	also	ADV
ajst-32250	89	8	negatively	negatively	ADV
ajst-32250	89	9	impact	impact	VERB
ajst-32250	89	10	phage	phage	NOUN
ajst-32250	89	11	therapy	therapy	NOUN
ajst-32250	89	12	by	by	ADP
ajst-32250	89	13	neutralizing	neutralize	VERB
ajst-32250	89	14	phages	phage	NOUN
ajst-32250	89	15	,	,	PUNCT
ajst-32250	89	16	leading	lead	VERB
ajst-32250	89	17	to	to	ADP
ajst-32250	89	18	potential	potential	ADJ
ajst-32250	89	19	toxicity	toxicity	NOUN
ajst-32250	89	20	and	and	CCONJ
ajst-32250	89	21	diminished	diminish	VERB
ajst-32250	89	22	efficacy	efficacy	NOUN
ajst-32250	89	23	.	.	PUNCT
ajst-32250	90	1	existing	exist	VERB
ajst-32250	90	2	pharmaceutical	pharmaceutical	ADJ
ajst-32250	90	3	regulations	regulation	NOUN
ajst-32250	90	4	are	be	AUX
ajst-32250	90	5	a	a	DET
ajst-32250	90	6	poor	poor	ADJ
ajst-32250	90	7	fit	fit	NOUN
ajst-32250	90	8	for	for	ADP
ajst-32250	90	9	bacteriophages	bacteriophage	NOUN
ajst-32250	90	10	,	,	PUNCT
ajst-32250	90	11	complex	complex	ADJ
ajst-32250	90	12	biological	biological	ADJ
ajst-32250	90	13	entities	entity	NOUN
ajst-32250	90	14	with	with	ADP
ajst-32250	90	15	unique	unique	ADJ
ajst-32250	90	16	characteristics	characteristic	NOUN
ajst-32250	90	17	like	like	ADP
ajst-32250	90	18	co	co	NOUN
ajst-32250	90	19	-	-	NOUN
ajst-32250	90	20	evolution	evolution	NOUN
ajst-32250	90	21	with	with	ADP
ajst-32250	90	22	bacteria	bacteria	NOUN
ajst-32250	90	23	.	.	PUNCT
ajst-32250	91	1	most	most	ADJ
ajst-32250	91	2	western	western	ADJ
ajst-32250	91	3	regulatory	regulatory	ADJ
ajst-32250	91	4	agencies	agency	NOUN
ajst-32250	91	5	,	,	PUNCT
ajst-32250	91	6	such	such	ADJ
ajst-32250	91	7	as	as	ADP
ajst-32250	91	8	the	the	DET
ajst-32250	91	9	fda	fda	PROPN
ajst-32250	91	10	and	and	CCONJ
ajst-32250	91	11	ema	ema	PROPN
ajst-32250	91	12	,	,	PUNCT
ajst-32250	91	13	have	have	AUX
ajst-32250	91	14	not	not	PART
ajst-32250	91	15	approved	approve	VERB
ajst-32250	91	16	natural	natural	ADJ
ajst-32250	91	17	bacteriophage	bacteriophage	NOUN
ajst-32250	91	18	products	product	NOUN
ajst-32250	91	19	for	for	ADP
ajst-32250	91	20	human	human	ADJ
ajst-32250	91	21	treatment	treatment	NOUN
ajst-32250	91	22	,	,	PUNCT
ajst-32250	91	23	mainly	mainly	ADV
ajst-32250	91	24	due	due	ADP
ajst-32250	91	25	to	to	ADP
ajst-32250	91	26	the	the	DET
ajst-32250	91	27	regulatory	regulatory	ADJ
ajst-32250	91	28	complexity	complexity	NOUN
ajst-32250	91	29	.	.	PUNCT
ajst-32250	92	1	in	in	ADP
ajst-32250	92	2	the	the	DET
ajst-32250	92	3	future	future	NOUN
ajst-32250	92	4	,	,	PUNCT
ajst-32250	92	5	researchers	researcher	NOUN
ajst-32250	92	6	should	should	AUX
ajst-32250	92	7	expand	expand	VERB
ajst-32250	92	8	clinical	clinical	ADJ
ajst-32250	92	9	trials	trial	NOUN
ajst-32250	92	10	for	for	ADP
ajst-32250	92	11	safety	safety	NOUN
ajst-32250	92	12	and	and	CCONJ
ajst-32250	92	13	efficacy	efficacy	NOUN
ajst-32250	92	14	verification	verification	NOUN
ajst-32250	92	15	.	.	PUNCT
ajst-32250	93	1	modern	modern	ADJ
ajst-32250	93	2	trials	trial	NOUN
ajst-32250	93	3	have	have	AUX
ajst-32250	93	4	consistently	consistently	ADV
ajst-32250	93	5	shown	show	VERB
ajst-32250	93	6	phage	phage	NOUN
ajst-32250	93	7	therapy	therapy	NOUN
ajst-32250	93	8	to	to	PART
ajst-32250	93	9	be	be	AUX
ajst-32250	93	10	safe	safe	ADJ
ajst-32250	93	11	,	,	PUNCT
ajst-32250	93	12	with	with	ADP
ajst-32250	93	13	adverse	adverse	ADJ
ajst-32250	93	14	effects	effect	NOUN
ajst-32250	93	15	in	in	ADP
ajst-32250	93	16	earlier	early	ADJ
ajst-32250	93	17	studies	study	NOUN
ajst-32250	93	18	often	often	ADV
ajst-32250	93	19	linked	link	VERB
ajst-32250	93	20	to	to	ADP
ajst-32250	93	21	non	non	ADJ
ajst-32250	93	22	-	-	ADJ
ajst-32250	93	23	specific	specific	ADJ
ajst-32250	93	24	bacterial	bacterial	ADJ
ajst-32250	93	25	debris	debris	NOUN
ajst-32250	93	26	contamination	contamination	NOUN
ajst-32250	93	27	,	,	PUNCT
ajst-32250	93	28	not	not	PART
ajst-32250	93	29	the	the	DET
ajst-32250	93	30	phages	phage	NOUN
ajst-32250	93	31	themselves	themselves	PRON
ajst-32250	93	32	.	.	PUNCT
ajst-32250	94	1	standardization	standardization	NOUN
ajst-32250	94	2	of	of	ADP
ajst-32250	94	3	manufacture	manufacture	NOUN
ajst-32250	94	4	and	and	CCONJ
ajst-32250	94	5	application	application	NOUN
ajst-32250	94	6	of	of	ADP
ajst-32250	94	7	phage	phage	NOUN
ajst-32250	94	8	plan	plan	NOUN
ajst-32250	94	9	formulation	formulation	NOUN
ajst-32250	94	10	is	be	AUX
ajst-32250	94	11	also	also	ADV
ajst-32250	94	12	necessary	necessary	ADJ
ajst-32250	94	13	.	.	PUNCT
ajst-32250	95	1	production	production	NOUN
ajst-32250	95	2	must	must	AUX
ajst-32250	95	3	start	start	VERB
ajst-32250	95	4	with	with	ADP
ajst-32250	95	5	genetically	genetically	ADV
ajst-32250	95	6	and	and	CCONJ
ajst-32250	95	7	phenotypically	phenotypically	ADV
ajst-32250	95	8	stable	stable	ADJ
ajst-32250	95	9	,	,	PUNCT
ajst-32250	95	10	characterized	characterize	VERB
ajst-32250	95	11	,	,	PUNCT
ajst-32250	95	12	and	and	CCONJ
ajst-32250	95	13	quality	quality	NOUN
ajst-32250	95	14	-	-	PUNCT
ajst-32250	95	15	controlled	control	VERB
ajst-32250	95	16	"	"	PUNCT
ajst-32250	95	17	seed	seed	NOUN
ajst-32250	95	18	lots	lot	NOUN
ajst-32250	95	19	"	"	PUNCT
ajst-32250	95	20	of	of	ADP
ajst-32250	95	21	the	the	DET
ajst-32250	95	22	bacteriophages	bacteriophage	NOUN
ajst-32250	95	23	and	and	CCONJ
ajst-32250	95	24	their	their	PRON
ajst-32250	95	25	bacterial	bacterial	ADJ
ajst-32250	95	26	hosts	host	NOUN
ajst-32250	95	27	.	.	PUNCT
ajst-32250	96	1	formulations	formulation	NOUN
ajst-32250	96	2	are	be	AUX
ajst-32250	96	3	developed	develop	VERB
ajst-32250	96	4	to	to	PART
ajst-32250	96	5	enhance	enhance	VERB
ajst-32250	96	6	stability	stability	NOUN
ajst-32250	96	7	(	(	PUNCT
ajst-32250	96	8	e.g.	e.g.	ADV
ajst-32250	96	9	,	,	PUNCT
ajst-32250	96	10	dry	dry	VERB
ajst-32250	96	11	42	42	NUM
ajst-32250	96	12	powders	powder	NOUN
ajst-32250	96	13	over	over	ADP
ajst-32250	96	14	liquids	liquid	NOUN
ajst-32250	96	15	)	)	PUNCT
ajst-32250	96	16	and	and	CCONJ
ajst-32250	96	17	improve	improve	VERB
ajst-32250	96	18	delivery	delivery	NOUN
ajst-32250	96	19	to	to	ADP
ajst-32250	96	20	the	the	DET
ajst-32250	96	21	target	target	NOUN
ajst-32250	96	22	site	site	NOUN
ajst-32250	96	23	.	.	PUNCT
ajst-32250	97	1	a	a	DET
ajst-32250	97	2	comprehensive	comprehensive	ADJ
ajst-32250	97	3	quality	quality	NOUN
ajst-32250	97	4	control	control	NOUN
ajst-32250	97	5	(	(	PUNCT
ajst-32250	97	6	qc	qc	PROPN
ajst-32250	97	7	)	)	PUNCT
ajst-32250	97	8	panel	panel	NOUN
ajst-32250	97	9	is	be	AUX
ajst-32250	97	10	applied	apply	VERB
ajst-32250	97	11	to	to	ADP
ajst-32250	97	12	finished	finish	VERB
ajst-32250	97	13	phage	phage	NOUN
ajst-32250	97	14	products	product	NOUN
ajst-32250	97	15	to	to	PART
ajst-32250	97	16	ensure	ensure	VERB
ajst-32250	97	17	they	they	PRON
ajst-32250	97	18	are	be	AUX
ajst-32250	97	19	safe	safe	ADJ
ajst-32250	97	20	and	and	CCONJ
ajst-32250	97	21	potent	potent	ADJ
ajst-32250	97	22	.	.	PUNCT
ajst-32250	98	1	a	a	DET
ajst-32250	98	2	gene	gene	NOUN
ajst-32250	98	3	editing	edit	VERB
ajst-32250	98	4	system	system	NOUN
ajst-32250	98	5	can	can	AUX
ajst-32250	98	6	be	be	AUX
ajst-32250	98	7	applied	apply	VERB
ajst-32250	98	8	to	to	PART
ajst-32250	98	9	explore	explore	VERB
ajst-32250	98	10	the	the	DET
ajst-32250	98	11	new	new	ADJ
ajst-32250	98	12	phage	phage	NOUN
ajst-32250	98	13	type	type	NOUN
ajst-32250	98	14	.	.	PUNCT
ajst-32250	99	1	crispr	crispr	ADJ
ajst-32250	99	2	-	-	PUNCT
ajst-32250	99	3	cas12a	cas12a	NOUN
ajst-32250	99	4	is	be	AUX
ajst-32250	99	5	highly	highly	ADV
ajst-32250	99	6	efficient	efficient	ADJ
ajst-32250	99	7	in	in	ADP
ajst-32250	99	8	introducing	introduce	VERB
ajst-32250	99	9	point	point	NOUN
ajst-32250	99	10	mutations	mutation	NOUN
ajst-32250	99	11	,	,	PUNCT
ajst-32250	99	12	deletions	deletion	NOUN
ajst-32250	99	13	,	,	PUNCT
ajst-32250	99	14	and	and	CCONJ
ajst-32250	99	15	insertions	insertion	NOUN
ajst-32250	99	16	into	into	ADP
ajst-32250	99	17	p.	p.	NOUN
ajst-32250	99	18	aeruginosa	aeruginosa	NOUN
ajst-32250	99	19	phages	phage	NOUN
ajst-32250	99	20	,	,	PUNCT
ajst-32250	99	21	surpassing	surpass	VERB
ajst-32250	99	22	the	the	DET
ajst-32250	99	23	efficiency	efficiency	NOUN
ajst-32250	99	24	of	of	ADP
ajst-32250	99	25	some	some	DET
ajst-32250	99	26	crispr	crispr	ADJ
ajst-32250	99	27	-	-	PUNCT
ajst-32250	99	28	cas9	cas9	NOUN
ajst-32250	99	29	systems	system	NOUN
ajst-32250	99	30	for	for	ADP
ajst-32250	99	31	specific	specific	ADJ
ajst-32250	99	32	phage	phage	NOUN
ajst-32250	99	33	types	type	NOUN
ajst-32250	99	34	.	.	PUNCT
ajst-32250	100	1	also	also	ADV
ajst-32250	100	2	,	,	PUNCT
ajst-32250	100	3	recombinons	recombinon	NOUN
ajst-32250	100	4	are	be	AUX
ajst-32250	100	5	a	a	DET
ajst-32250	100	6	novel	novel	ADJ
ajst-32250	100	7	system	system	NOUN
ajst-32250	100	8	that	that	PRON
ajst-32250	100	9	utilizes	utilize	VERB
ajst-32250	100	10	a	a	DET
ajst-32250	100	11	retron	retron	NOUN
ajst-32250	100	12	reverse	reverse	NOUN
ajst-32250	100	13	transcriptase	transcriptase	NOUN
ajst-32250	100	14	to	to	PART
ajst-32250	100	15	create	create	VERB
ajst-32250	100	16	a	a	DET
ajst-32250	100	17	dna	dna	ADJ
ajst-32250	100	18	-	-	PUNCT
ajst-32250	100	19	rna	rna	NOUN
ajst-32250	100	20	template	template	NOUN
ajst-32250	100	21	that	that	PRON
ajst-32250	100	22	is	be	AUX
ajst-32250	100	23	then	then	ADV
ajst-32250	100	24	used	use	VERB
ajst-32250	100	25	for	for	ADP
ajst-32250	100	26	editing	edit	VERB
ajst-32250	100	27	without	without	ADP
ajst-32250	100	28	an	an	DET
ajst-32250	100	29	active	active	ADJ
ajst-32250	100	30	crispr	crispr	ADJ
ajst-32250	100	31	defense	defense	NOUN
ajst-32250	100	32	system	system	NOUN
ajst-32250	100	33	.	.	PUNCT
ajst-32250	101	1	this	this	DET
ajst-32250	101	2	method	method	NOUN
ajst-32250	101	3	allows	allow	VERB
ajst-32250	101	4	for	for	ADP
ajst-32250	101	5	continuous	continuous	ADJ
ajst-32250	101	6	,	,	PUNCT
ajst-32250	101	7	multiplexed	multiplexed	ADJ
ajst-32250	101	8	editing	editing	NOUN
ajst-32250	101	9	.	.	PUNCT
ajst-32250	102	1	[	[	X
ajst-32250	102	2	6	6	NUM
ajst-32250	102	3	-	-	SYM
ajst-32250	102	4	7	7	NUM
ajst-32250	102	5	]	]	PUNCT
ajst-32250	102	6	lastly	lastly	ADV
ajst-32250	102	7	,	,	PUNCT
ajst-32250	102	8	integrating	integrate	VERB
ajst-32250	102	9	personalized	personalized	ADJ
ajst-32250	102	10	medicine	medicine	NOUN
ajst-32250	102	11	methods	method	NOUN
ajst-32250	102	12	can	can	AUX
ajst-32250	102	13	obtain	obtain	VERB
ajst-32250	102	14	the	the	DET
ajst-32250	102	15	best	good	ADJ
ajst-32250	102	16	results	result	NOUN
ajst-32250	102	17	.	.	PUNCT
ajst-32250	103	1	key	key	ADJ
ajst-32250	103	2	steps	step	NOUN
ajst-32250	103	3	to	to	PART
ajst-32250	103	4	consider	consider	VERB
ajst-32250	103	5	are	be	AUX
ajst-32250	103	6	building	build	VERB
ajst-32250	103	7	robust	robust	ADJ
ajst-32250	103	8	informatics	informatic	NOUN
ajst-32250	103	9	systems	system	NOUN
ajst-32250	103	10	to	to	PART
ajst-32250	103	11	manage	manage	VERB
ajst-32250	103	12	patient	patient	ADJ
ajst-32250	103	13	data	datum	NOUN
ajst-32250	103	14	,	,	PUNCT
ajst-32250	103	15	fostering	foster	VERB
ajst-32250	103	16	a	a	DET
ajst-32250	103	17	collaborative	collaborative	ADJ
ajst-32250	103	18	approach	approach	NOUN
ajst-32250	103	19	among	among	ADP
ajst-32250	103	20	healthcare	healthcare	NOUN
ajst-32250	103	21	professionals	professional	NOUN
ajst-32250	103	22	,	,	PUNCT
ajst-32250	103	23	educating	educate	VERB
ajst-32250	103	24	patients	patient	NOUN
ajst-32250	103	25	on	on	ADP
ajst-32250	103	26	their	their	PRON
ajst-32250	103	27	role	role	NOUN
ajst-32250	103	28	,	,	PUNCT
ajst-32250	103	29	establishing	establish	VERB
ajst-32250	103	30	clear	clear	ADJ
ajst-32250	103	31	ethical	ethical	ADJ
ajst-32250	103	32	guidelines	guideline	NOUN
ajst-32250	103	33	for	for	ADP
ajst-32250	103	34	data	data	NOUN
ajst-32250	103	35	use	use	NOUN
ajst-32250	103	36	,	,	PUNCT
ajst-32250	103	37	and	and	CCONJ
ajst-32250	103	38	developing	develop	VERB
ajst-32250	103	39	comprehensive	comprehensive	ADJ
ajst-32250	103	40	strategies	strategy	NOUN
ajst-32250	103	41	for	for	ADP
ajst-32250	103	42	research	research	NOUN
ajst-32250	103	43	and	and	CCONJ
ajst-32250	103	44	implementation	implementation	NOUN
ajst-32250	103	45	.	.	PUNCT
ajst-32250	104	1	6	6	X
ajst-32250	104	2	.	.	X
ajst-32250	104	3	conclusion	conclusion	VERB
ajst-32250	104	4	the	the	DET
ajst-32250	104	5	application	application	NOUN
ajst-32250	104	6	of	of	ADP
ajst-32250	104	7	bacteriophage	bacteriophage	NOUN
ajst-32250	104	8	targeting	target	VERB
ajst-32250	104	9	in	in	ADP
ajst-32250	104	10	hiv	hiv	PROPN
ajst-32250	104	11	therapy	therapy	NOUN
ajst-32250	104	12	presents	present	VERB
ajst-32250	104	13	a	a	DET
ajst-32250	104	14	novel	novel	NOUN
ajst-32250	104	15	and	and	CCONJ
ajst-32250	104	16	promising	promising	ADJ
ajst-32250	104	17	approach	approach	NOUN
ajst-32250	104	18	in	in	ADP
ajst-32250	104	19	the	the	DET
ajst-32250	104	20	fight	fight	NOUN
ajst-32250	104	21	against	against	ADP
ajst-32250	104	22	hiv	hiv	PROPN
ajst-32250	104	23	.	.	PUNCT
ajst-32250	105	1	bacteriophages	bacteriophage	NOUN
ajst-32250	105	2	,	,	PUNCT
ajst-32250	105	3	or	or	CCONJ
ajst-32250	105	4	phages	phage	NOUN
ajst-32250	105	5	,	,	PUNCT
ajst-32250	105	6	are	be	AUX
ajst-32250	105	7	viruses	virus	NOUN
ajst-32250	105	8	that	that	PRON
ajst-32250	105	9	specifically	specifically	ADV
ajst-32250	105	10	infect	infect	ADJ
ajst-32250	105	11	bacteria	bacteria	NOUN
ajst-32250	105	12	,	,	PUNCT
ajst-32250	105	13	and	and	CCONJ
ajst-32250	105	14	recent	recent	ADJ
ajst-32250	105	15	research	research	NOUN
ajst-32250	105	16	has	have	AUX
ajst-32250	105	17	explored	explore	VERB
ajst-32250	105	18	their	their	PRON
ajst-32250	105	19	potential	potential	NOUN
ajst-32250	105	20	in	in	ADP
ajst-32250	105	21	targeting	target	VERB
ajst-32250	105	22	bacterial	bacterial	ADJ
ajst-32250	105	23	populations	population	NOUN
ajst-32250	105	24	in	in	ADP
ajst-32250	105	25	the	the	DET
ajst-32250	105	26	human	human	ADJ
ajst-32250	105	27	microbiome	microbiome	NOUN
ajst-32250	105	28	that	that	PRON
ajst-32250	105	29	may	may	AUX
ajst-32250	105	30	influence	influence	VERB
ajst-32250	105	31	hiv	hiv	PROPN
ajst-32250	105	32	pathogenesis	pathogenesis	NOUN
ajst-32250	105	33	or	or	CCONJ
ajst-32250	105	34	resistance	resistance	NOUN
ajst-32250	105	35	.	.	PUNCT
ajst-32250	106	1	moreover	moreover	ADV
ajst-32250	106	2	,	,	PUNCT
ajst-32250	106	3	bacteriophages	bacteriophage	NOUN
ajst-32250	106	4	could	could	AUX
ajst-32250	106	5	be	be	AUX
ajst-32250	106	6	used	use	VERB
ajst-32250	106	7	as	as	ADP
ajst-32250	106	8	vectors	vector	NOUN
ajst-32250	106	9	for	for	ADP
ajst-32250	106	10	gene	gene	NOUN
ajst-32250	106	11	delivery	delivery	NOUN
ajst-32250	106	12	,	,	PUNCT
ajst-32250	106	13	potentially	potentially	ADV
ajst-32250	106	14	enabling	enable	VERB
ajst-32250	106	15	the	the	DET
ajst-32250	106	16	precise	precise	ADJ
ajst-32250	106	17	targeting	targeting	NOUN
ajst-32250	106	18	of	of	ADP
ajst-32250	106	19	hiv	hiv	PROPN
ajst-32250	106	20	-	-	PUNCT
ajst-32250	106	21	infected	infect	VERB
ajst-32250	106	22	cells	cell	NOUN
ajst-32250	106	23	.	.	PUNCT
ajst-32250	107	1	although	although	SCONJ
ajst-32250	107	2	this	this	DET
ajst-32250	107	3	area	area	NOUN
ajst-32250	107	4	of	of	ADP
ajst-32250	107	5	research	research	NOUN
ajst-32250	107	6	is	be	AUX
ajst-32250	107	7	still	still	ADV
ajst-32250	107	8	in	in	ADP
ajst-32250	107	9	its	its	PRON
ajst-32250	107	10	early	early	ADJ
ajst-32250	107	11	stages	stage	NOUN
ajst-32250	107	12	,	,	PUNCT
ajst-32250	107	13	phage	phage	NOUN
ajst-32250	107	14	therapy	therapy	NOUN
ajst-32250	107	15	has	have	AUX
ajst-32250	107	16	shown	show	VERB
ajst-32250	107	17	promise	promise	NOUN
ajst-32250	107	18	in	in	ADP
ajst-32250	107	19	overcoming	overcome	VERB
ajst-32250	107	20	challenges	challenge	NOUN
ajst-32250	107	21	associated	associate	VERB
ajst-32250	107	22	with	with	ADP
ajst-32250	107	23	traditional	traditional	ADJ
ajst-32250	107	24	hiv	hiv	PROPN
ajst-32250	107	25	treatments	treatment	NOUN
ajst-32250	107	26	,	,	PUNCT
ajst-32250	107	27	such	such	ADJ
ajst-32250	107	28	as	as	ADP
ajst-32250	107	29	viral	viral	ADJ
ajst-32250	107	30	resistance	resistance	NOUN
ajst-32250	107	31	and	and	CCONJ
ajst-32250	107	32	limited	limited	ADJ
ajst-32250	107	33	drug	drug	NOUN
ajst-32250	107	34	efficacy	efficacy	NOUN
ajst-32250	107	35	.	.	PUNCT
ajst-32250	108	1	by	by	ADP
ajst-32250	108	2	enhancing	enhance	VERB
ajst-32250	108	3	the	the	DET
ajst-32250	108	4	immune	immune	ADJ
ajst-32250	108	5	system	system	NOUN
ajst-32250	108	6	's	's	PART
ajst-32250	108	7	ability	ability	NOUN
ajst-32250	108	8	to	to	PART
ajst-32250	108	9	control	control	VERB
ajst-32250	108	10	the	the	DET
ajst-32250	108	11	virus	virus	NOUN
ajst-32250	108	12	or	or	CCONJ
ajst-32250	108	13	directly	directly	ADV
ajst-32250	108	14	targeting	target	VERB
ajst-32250	108	15	viral	viral	ADJ
ajst-32250	108	16	reservoirs	reservoir	NOUN
ajst-32250	108	17	,	,	PUNCT
ajst-32250	108	18	phage	phage	NOUN
ajst-32250	108	19	-	-	PUNCT
ajst-32250	108	20	based	base	VERB
ajst-32250	108	21	therapies	therapy	NOUN
ajst-32250	108	22	could	could	AUX
ajst-32250	108	23	serve	serve	VERB
ajst-32250	108	24	as	as	ADP
ajst-32250	108	25	adjuncts	adjunct	NOUN
ajst-32250	108	26	to	to	ADP
ajst-32250	108	27	existing	exist	VERB
ajst-32250	108	28	antiretroviral	antiretroviral	ADJ
ajst-32250	108	29	treatments	treatment	NOUN
ajst-32250	108	30	.	.	PUNCT
ajst-32250	109	1	however	however	ADV
ajst-32250	109	2	,	,	PUNCT
ajst-32250	109	3	further	far	ADV
ajst-32250	109	4	clinical	clinical	ADJ
ajst-32250	109	5	trials	trial	NOUN
ajst-32250	109	6	and	and	CCONJ
ajst-32250	109	7	studies	study	NOUN
ajst-32250	109	8	are	be	AUX
ajst-32250	109	9	essential	essential	ADJ
ajst-32250	109	10	to	to	PART
ajst-32250	109	11	assess	assess	VERB
ajst-32250	109	12	their	their	PRON
ajst-32250	109	13	safety	safety	NOUN
ajst-32250	109	14	,	,	PUNCT
ajst-32250	109	15	efficacy	efficacy	NOUN
ajst-32250	109	16	,	,	PUNCT
ajst-32250	109	17	and	and	CCONJ
ajst-32250	109	18	long	long	ADJ
ajst-32250	109	19	-	-	PUNCT
ajst-32250	109	20	term	term	NOUN
ajst-32250	109	21	effects	effect	NOUN
ajst-32250	109	22	before	before	SCONJ
ajst-32250	109	23	they	they	PRON
ajst-32250	109	24	can	can	AUX
ajst-32250	109	25	be	be	AUX
ajst-32250	109	26	widely	widely	ADV
ajst-32250	109	27	implemented	implement	VERB
ajst-32250	109	28	in	in	ADP
ajst-32250	109	29	hiv	hiv	PROPN
ajst-32250	109	30	treatment	treatment	NOUN
ajst-32250	109	31	regimens	regimen	NOUN
ajst-32250	109	32	.	.	PUNCT
ajst-32250	110	1	in	in	ADP
ajst-32250	110	2	conclusion	conclusion	NOUN
ajst-32250	110	3	,	,	PUNCT
ajst-32250	110	4	while	while	SCONJ
ajst-32250	110	5	bacteriophage	bacteriophage	NOUN
ajst-32250	110	6	targeting	target	VERB
ajst-32250	110	7	in	in	ADP
ajst-32250	110	8	hiv	hiv	PROPN
ajst-32250	110	9	therapy	therapy	NOUN
ajst-32250	110	10	remains	remain	VERB
ajst-32250	110	11	an	an	DET
ajst-32250	110	12	exciting	exciting	ADJ
ajst-32250	110	13	area	area	NOUN
ajst-32250	110	14	of	of	ADP
ajst-32250	110	15	exploration	exploration	NOUN
ajst-32250	110	16	,	,	PUNCT
ajst-32250	110	17	it	it	PRON
ajst-32250	110	18	requires	require	VERB
ajst-32250	110	19	significant	significant	ADJ
ajst-32250	110	20	research	research	NOUN
ajst-32250	110	21	to	to	PART
ajst-32250	110	22	determine	determine	VERB
ajst-32250	110	23	its	its	PRON
ajst-32250	110	24	full	full	ADJ
ajst-32250	110	25	potential	potential	NOUN
ajst-32250	110	26	and	and	CCONJ
ajst-32250	110	27	integration	integration	NOUN
ajst-32250	110	28	into	into	ADP
ajst-32250	110	29	standard	standard	PROPN
ajst-32250	110	30	hiv	hiv	PROPN
ajst-32250	110	31	care	care	NOUN
ajst-32250	110	32	.	.	PUNCT
ajst-32250	111	1	references	reference	NOUN
ajst-32250	111	2	[	[	X
ajst-32250	111	3	1	1	NUM
ajst-32250	111	4	]	]	PUNCT
ajst-32250	111	5	delhalle	delhalle	NOUN
ajst-32250	111	6	s	s	PROPN
ajst-32250	111	7	,	,	PUNCT
ajst-32250	111	8	schmit	schmit	PROPN
ajst-32250	111	9	jc	jc	PROPN
ajst-32250	111	10	,	,	PUNCT
ajst-32250	111	11	chevigné	chevigné	ADJ
ajst-32250	111	12	a.	a.	NOUN
ajst-32250	111	13	phages	phage	NOUN
ajst-32250	111	14	and	and	CCONJ
ajst-32250	111	15	hiv-1	hiv-1	X
ajst-32250	111	16	:	:	PUNCT
ajst-32250	111	17	from	from	ADP
ajst-32250	111	18	display	display	NOUN
ajst-32250	111	19	to	to	ADP
ajst-32250	111	20	interplay	interplay	NOUN
ajst-32250	111	21	.	.	PUNCT
ajst-32250	112	1	int	int	PROPN
ajst-32250	112	2	j	j	PROPN
ajst-32250	112	3	mol	mol	ADP
ajst-32250	112	4	sci	sci	PROPN
ajst-32250	112	5	.	.	PUNCT
ajst-32250	113	1	2012;13(4):4727	2012;13(4):4727	PROPN
ajst-32250	113	2	-	-	PUNCT
ajst-32250	113	3	4794	4794	NUM
ajst-32250	113	4	.	.	PUNCT
ajst-32250	114	1	doi	doi	NOUN
ajst-32250	114	2	:	:	PUNCT
ajst-32250	114	3	10.3390	10.3390	NUM
ajst-32250	114	4	/	/	SYM
ajst-32250	114	5	ijms13044727	ijms13044727	PROPN
ajst-32250	114	6	.	.	PUNCT
ajst-32250	115	1	[	[	X
ajst-32250	115	2	2	2	NUM
ajst-32250	115	3	]	]	PUNCT
ajst-32250	115	4	drulis	drulis	PROPN
ajst-32250	115	5	-	-	PUNCT
ajst-32250	115	6	kawa	kawa	PROPN
ajst-32250	115	7	z	z	PROPN
ajst-32250	115	8	,	,	PUNCT
ajst-32250	115	9	majkowska	majkowska	NOUN
ajst-32250	115	10	-	-	PUNCT
ajst-32250	115	11	skrobek	skrobek	NOUN
ajst-32250	115	12	g	g	PROPN
ajst-32250	115	13	,	,	PUNCT
ajst-32250	115	14	maciejewska	maciejewska	PROPN
ajst-32250	115	15	b.	b.	PROPN
ajst-32250	115	16	bacteriophages	bacteriophage	NOUN
ajst-32250	115	17	and	and	CCONJ
ajst-32250	115	18	phage	phage	NOUN
ajst-32250	115	19	-	-	PUNCT
ajst-32250	115	20	derived	derive	VERB
ajst-32250	115	21	proteins	protein	NOUN
ajst-32250	115	22	-	-	PUNCT
ajst-32250	115	23	application	application	NOUN
ajst-32250	115	24	approaches	approach	NOUN
ajst-32250	115	25	.	.	PUNCT
ajst-32250	116	1	curr	curr	PROPN
ajst-32250	116	2	med	med	PROPN
ajst-32250	116	3	chem	chem	NOUN
ajst-32250	116	4	.	.	PUNCT
ajst-32250	117	1	2015;22(14):1757	2015;22(14):1757	NUM
ajst-32250	117	2	-	-	SYM
ajst-32250	117	3	73	73	NUM
ajst-32250	117	4	.	.	PUNCT
ajst-32250	118	1	doi	doi	NOUN
ajst-32250	118	2	:	:	PUNCT
ajst-32250	118	3	10.2174/09298673226661502091	10.2174/09298673226661502091	NUM
ajst-32250	118	4	52851	52851	NUM
ajst-32250	118	5	.	.	PUNCT
ajst-32250	119	1	[	[	X
ajst-32250	119	2	3	3	NUM
ajst-32250	119	3	]	]	AUX
ajst-32250	119	4	górski	górski	NOUN
ajst-32250	119	5	a	a	PRON
ajst-32250	119	6	,	,	PUNCT
ajst-32250	119	7	międzybrodzki	międzybrodzki	ADJ
ajst-32250	119	8	r	r	NOUN
ajst-32250	119	9	,	,	PUNCT
ajst-32250	119	10	jończyk	jończyk	NOUN
ajst-32250	119	11	-	-	PUNCT
ajst-32250	119	12	matysiak	matysiak	PROPN
ajst-32250	119	13	e	e	PROPN
ajst-32250	119	14	,	,	PUNCT
ajst-32250	119	15	kniotek	kniotek	PROPN
ajst-32250	119	16	m	m	PROPN
ajst-32250	119	17	,	,	PUNCT
ajst-32250	119	18	letkiewicz	letkiewicz	PROPN
ajst-32250	119	19	s.	s.	PROPN
ajst-32250	119	20	therapeutic	therapeutic	ADJ
ajst-32250	119	21	phages	phage	NOUN
ajst-32250	119	22	as	as	ADP
ajst-32250	119	23	modulators	modulator	NOUN
ajst-32250	119	24	of	of	ADP
ajst-32250	119	25	the	the	DET
ajst-32250	119	26	immune	immune	ADJ
ajst-32250	119	27	response	response	NOUN
ajst-32250	119	28	:	:	PUNCT
ajst-32250	119	29	practical	practical	ADJ
ajst-32250	119	30	implications	implication	NOUN
ajst-32250	119	31	.	.	PUNCT
ajst-32250	120	1	clin	clin	PROPN
ajst-32250	120	2	infect	infect	PROPN
ajst-32250	120	3	dis	dis	PROPN
ajst-32250	120	4	.	.	PUNCT
ajst-32250	121	1	2023	2023	NUM
ajst-32250	121	2	nov	nov	NOUN
ajst-32250	121	3	2;77(suppl	2;77(suppl	NUM
ajst-32250	121	4	5	5	NUM
ajst-32250	121	5	):	):	PUNCT
ajst-32250	121	6	s433	s433	NUM
ajst-32250	121	7	-	-	PUNCT
ajst-32250	121	8	s439	s439	PROPN
ajst-32250	121	9	.	.	PUNCT
ajst-32250	122	1	doi	doi	NOUN
ajst-32250	122	2	:	:	PUNCT
ajst-32250	122	3	10.1093	10.1093	NUM
ajst-32250	122	4	/	/	SYM
ajst-32250	122	5	cid	cid	PROPN
ajst-32250	122	6	/	/	SYM
ajst-32250	122	7	ciad483	ciad483	PROPN
ajst-32250	122	8	.	.	PUNCT
ajst-32250	123	1	[	[	X
ajst-32250	123	2	4	4	NUM
ajst-32250	123	3	]	]	X
ajst-32250	123	4	gordillo	gordillo	PROPN
ajst-32250	123	5	altamirano	altamirano	PROPN
ajst-32250	123	6	fl	fl	PROPN
ajst-32250	123	7	,	,	PUNCT
ajst-32250	123	8	barr	barr	PROPN
ajst-32250	123	9	jj	jj	PROPN
ajst-32250	123	10	.	.	PROPN
ajst-32250	123	11	phage	phage	NOUN
ajst-32250	123	12	therapy	therapy	NOUN
ajst-32250	123	13	in	in	ADP
ajst-32250	123	14	the	the	DET
ajst-32250	123	15	postantibiotic	postantibiotic	ADJ
ajst-32250	123	16	era	era	NOUN
ajst-32250	123	17	.	.	PUNCT
ajst-32250	124	1	clin	clin	PROPN
ajst-32250	124	2	microbiol	microbiol	PROPN
ajst-32250	124	3	rev	rev	VERB
ajst-32250	124	4	.	.	PROPN
ajst-32250	124	5	2019	2019	NUM
ajst-32250	124	6	jan	jan	PROPN
ajst-32250	124	7	16;32(2):e00066	16;32(2):e00066	NUM
ajst-32250	124	8	-	-	SYM
ajst-32250	124	9	18	18	NUM
ajst-32250	124	10	.	.	PUNCT
ajst-32250	125	1	doi	doi	NOUN
ajst-32250	125	2	:	:	PUNCT
ajst-32250	125	3	10.1128	10.1128	NUM
ajst-32250	125	4	/	/	SYM
ajst-32250	125	5	cmr.00066	cmr.00066	NUM
ajst-32250	125	6	-	-	SYM
ajst-32250	125	7	18	18	NUM
ajst-32250	125	8	.	.	PUNCT
ajst-32250	126	1	pmid	pmid	NOUN
ajst-32250	126	2	:	:	PUNCT
ajst-32250	126	3	30651225	30651225	NUM
ajst-32250	126	4	.	.	PUNCT
ajst-32250	127	1	[	[	X
ajst-32250	127	2	5	5	NUM
ajst-32250	127	3	]	]	X
ajst-32250	127	4	himanshu	himanshu	PROPN
ajst-32250	127	5	batra	batra	PROPN
ajst-32250	127	6	,	,	PUNCT
ajst-32250	127	7	jingen	jingen	PROPN
ajst-32250	127	8	zhu	zhu	PROPN
ajst-32250	127	9	,	,	PUNCT
ajst-32250	127	10	swati	swati	PROPN
ajst-32250	127	11	jain	jain	PROPN
ajst-32250	127	12	,	,	PUNCT
ajst-32250	127	13	neeti	neeti	PROPN
ajst-32250	127	14	ananthaswamy	ananthaswamy	PROPN
ajst-32250	127	15	,	,	PUNCT
ajst-32250	127	16	marthandan	marthandan	PROPN
ajst-32250	127	17	mahalingam	mahalingam	PROPN
ajst-32250	127	18	,	,	PUNCT
ajst-32250	127	19	pan	pan	PROPN
ajst-32250	127	20	tao	tao	PROPN
ajst-32250	127	21	,	,	PUNCT
ajst-32250	127	22	ca	ca	PROPN
ajst-32250	127	23	mille	mille	PROPN
ajst-32250	127	24	lange	lange	PROPN
ajst-32250	127	25	,	,	PUNCT
ajst-32250	127	26	shawn	shawn	PROPN
ajst-32250	127	27	hill	hill	PROPN
ajst-32250	127	28	,	,	PUNCT
ajst-32250	127	29	chaojie	chaojie	ADP
ajst-32250	127	30	zhong	zhong	PROPN
ajst-32250	127	31	,	,	PUNCT
ajst-32250	127	32	mary	mary	PROPN
ajst-32250	127	33	f.	f.	PROPN
ajst-32250	127	34	kearney	kearney	PROPN
ajst-32250	127	35	,	,	PUNCT
ajst-32250	127	36	haitao	haitao	PROPN
ajst-32250	127	37	hu	hu	PROPN
ajst-32250	127	38	,	,	PUNCT
ajst-32250	127	39	frank	frank	PROPN
ajst-32250	127	40	maldarelli	maldarelli	PROPN
ajst-32250	127	41	,	,	PUNCT
ajst-32250	127	42	venigalla	venigalla	PROPN
ajst-32250	127	43	b.	b.	PROPN
ajst-32250	127	44	rao	rao	PROPN
ajst-32250	127	45	.	.	PUNCT
ajst-32250	128	1	biorxiv	biorxiv	PROPN
ajst-32250	128	2	.	.	PUNCT
ajst-32250	129	1	doi	doi	NOUN
ajst-32250	129	2	:	:	PUNCT
ajst-32250	129	3	https://doi.org/10.1101/2021.07.20.453091	https://doi.org/10.1101/2021.07.20.453091	ADJ
ajst-32250	129	4	.	.	PUNCT
ajst-32250	130	1	[	[	X
ajst-32250	130	2	6	6	NUM
ajst-32250	130	3	]	]	SYM
ajst-32250	130	4	seven	seven	NUM
ajst-32250	130	5	diseases	disease	NOUN
ajst-32250	130	6	crispr	crispr	ADJ
ajst-32250	130	7	technology	technology	NOUN
ajst-32250	130	8	could	could	AUX
ajst-32250	130	9	cure	cure	VERB
ajst-32250	130	10	.	.	PUNCT
ajst-32250	131	1	retrieved	retrieve	VERB
ajst-32250	131	2	from	from	ADP
ajst-32250	131	3	:	:	PUNCT
ajst-32250	131	4	https://www.labiotech.eu/in-depth/	https://www.labiotech.eu/in-depth/	NUM
ajst-32250	131	5	crispr	crispr	ADJ
ajst-32250	131	6	-	-	PUNCT
ajst-32250	131	7	technology	technology	NOUN
ajst-32250	131	8	-	-	PUNCT
ajst-32250	131	9	cure	cure	NOUN
ajst-32250	131	10	-	-	PUNCT
ajst-32250	131	11	disease/.	disease/.	NOUN
ajst-32250	131	12	[	[	X
ajst-32250	131	13	7	7	X
ajst-32250	131	14	]	]	X
ajst-32250	131	15	hussein	hussein	PROPN
ajst-32250	131	16	m	m	PROPN
ajst-32250	131	17	,	,	PUNCT
ajst-32250	131	18	molina	molina	PROPN
ajst-32250	131	19	ma	ma	PROPN
ajst-32250	131	20	,	,	PUNCT
ajst-32250	131	21	berkhout	berkhout	PROPN
ajst-32250	131	22	b	b	PROPN
ajst-32250	131	23	,	,	PUNCT
ajst-32250	131	24	herrera	herrera	NOUN
ajst-32250	131	25	-	-	PUNCT
ajst-32250	131	26	carrillo	carrillo	PROPN
ajst-32250	131	27	e.	e.	PROPN
ajst-32250	132	1	a	a	DET
ajst-32250	132	2	crispr	crispr	NOUN
ajst-32250	132	3	-	-	PUNCT
ajst-32250	132	4	cas	cas	NOUN
ajst-32250	132	5	cure	cure	NOUN
ajst-32250	132	6	for	for	ADP
ajst-32250	132	7	hiv	hiv	PROPN
ajst-32250	132	8	/	/	SYM
ajst-32250	132	9	aids	aids	PROPN
ajst-32250	132	10	.	.	PUNCT
ajst-32250	133	1	int	int	PROPN
ajst-32250	133	2	j	j	PROPN
ajst-32250	133	3	mol	mol	ADP
ajst-32250	133	4	sci	sci	PROPN
ajst-32250	133	5	.	.	PROPN
ajst-32250	134	1	2023	2023	NUM
ajst-32250	134	2	jan	jan	PROPN
ajst-32250	134	3	13;24(2):1563	13;24(2):1563	NUM
ajst-32250	134	4	.	.	PUNCT
ajst-32250	135	1	doi	doi	NOUN
ajst-32250	135	2	:	:	PUNCT
ajst-32250	135	3	10.3390	10.3390	NUM
ajst-32250	135	4	/	/	SYM
ajst-32250	135	5	ijms24021563	ijms24021563	PROPN
ajst-32250	135	6	.	.	PUNCT