id	sid	tid	token	lemma	pos
ajst-32269	1	1	58	58	NUM
ajst-32269	1	2	molecular	molecular	ADJ
ajst-32269	1	3	biomarkers	biomarker	NOUN
ajst-32269	1	4	in	in	ADP
ajst-32269	1	5	environmental	environmental	ADJ
ajst-32269	1	6	health	health	NOUN
ajst-32269	1	7	research	research	NOUN
ajst-32269	1	8	:	:	PUNCT
ajst-32269	1	9	advances	advance	NOUN
ajst-32269	1	10	and	and	CCONJ
ajst-32269	1	11	public	public	ADJ
ajst-32269	1	12	health	health	NOUN
ajst-32269	1	13	applications	application	NOUN
ajst-32269	1	14	chentian	chentian	PROPN
ajst-32269	1	15	hu	hu	PROPN
ajst-32269	1	16	fuzhou	fuzhou	PROPN
ajst-32269	1	17	university	university	PROPN
ajst-32269	1	18	,	,	PUNCT
ajst-32269	1	19	fuzhou	fuzhou	PROPN
ajst-32269	1	20	,	,	PUNCT
ajst-32269	1	21	fujian	fujian	PROPN
ajst-32269	1	22	,	,	PUNCT
ajst-32269	1	23	china	china	PROPN
ajst-32269	1	24	3219057528@qq.com	3219057528@qq.com	NUM
ajst-32269	1	25	abstract	abstract	NOUN
ajst-32269	1	26	.	.	PUNCT
ajst-32269	2	1	environmental	environmental	ADJ
ajst-32269	2	2	factors	factor	NOUN
ajst-32269	2	3	pose	pose	VERB
ajst-32269	2	4	significant	significant	ADJ
ajst-32269	2	5	public	public	ADJ
ajst-32269	2	6	health	health	NOUN
ajst-32269	2	7	risks	risk	NOUN
ajst-32269	2	8	.	.	PUNCT
ajst-32269	3	1	traditional	traditional	ADJ
ajst-32269	3	2	epidemiological	epidemiological	ADJ
ajst-32269	3	3	studies	study	NOUN
ajst-32269	3	4	face	face	VERB
ajst-32269	3	5	limitations	limitation	NOUN
ajst-32269	3	6	in	in	ADP
ajst-32269	3	7	accurately	accurately	ADV
ajst-32269	3	8	assessing	assess	VERB
ajst-32269	3	9	individual	individual	ADJ
ajst-32269	3	10	exposure	exposure	NOUN
ajst-32269	3	11	,	,	PUNCT
ajst-32269	3	12	elucidating	elucidate	VERB
ajst-32269	3	13	underlying	underlie	VERB
ajst-32269	3	14	mechanisms	mechanism	NOUN
ajst-32269	3	15	,	,	PUNCT
ajst-32269	3	16	and	and	CCONJ
ajst-32269	3	17	identifying	identify	VERB
ajst-32269	3	18	susceptible	susceptible	ADJ
ajst-32269	3	19	populations	population	NOUN
ajst-32269	3	20	.	.	PUNCT
ajst-32269	4	1	utilizing	utilize	VERB
ajst-32269	4	2	specific	specific	ADJ
ajst-32269	4	3	biomarkers	biomarker	NOUN
ajst-32269	4	4	,	,	PUNCT
ajst-32269	4	5	molecular	molecular	ADJ
ajst-32269	4	6	epidemiology	epidemiology	NOUN
ajst-32269	4	7	provides	provide	VERB
ajst-32269	4	8	a	a	DET
ajst-32269	4	9	powerful	powerful	ADJ
ajst-32269	4	10	tool	tool	NOUN
ajst-32269	4	11	to	to	PART
ajst-32269	4	12	unravel	unravel	VERB
ajst-32269	4	13	the	the	DET
ajst-32269	4	14	"	"	PUNCT
ajst-32269	4	15	black	black	ADJ
ajst-32269	4	16	box	box	NOUN
ajst-32269	4	17	"	"	PUNCT
ajst-32269	4	18	between	between	ADP
ajst-32269	4	19	environmental	environmental	ADJ
ajst-32269	4	20	exposure	exposure	NOUN
ajst-32269	4	21	and	and	CCONJ
ajst-32269	4	22	health	health	NOUN
ajst-32269	4	23	outcomes	outcome	NOUN
ajst-32269	4	24	.	.	PUNCT
ajst-32269	5	1	this	this	DET
ajst-32269	5	2	article	article	NOUN
ajst-32269	5	3	systematically	systematically	ADV
ajst-32269	5	4	reviews	review	VERB
ajst-32269	5	5	the	the	DET
ajst-32269	5	6	advances	advance	NOUN
ajst-32269	5	7	and	and	CCONJ
ajst-32269	5	8	applications	application	NOUN
ajst-32269	5	9	of	of	ADP
ajst-32269	5	10	molecular	molecular	ADJ
ajst-32269	5	11	biomarkers	biomarker	NOUN
ajst-32269	5	12	in	in	ADP
ajst-32269	5	13	environmental	environmental	ADJ
ajst-32269	5	14	health	health	NOUN
ajst-32269	5	15	research	research	NOUN
ajst-32269	5	16	.	.	PUNCT
ajst-32269	6	1	firstly	firstly	ADV
ajst-32269	6	2	,	,	PUNCT
ajst-32269	6	3	based	base	VERB
ajst-32269	6	4	on	on	ADP
ajst-32269	6	5	the	the	DET
ajst-32269	6	6	"	"	PUNCT
ajst-32269	6	7	exposure	exposure	NOUN
ajst-32269	6	8	-	-	PUNCT
ajst-32269	6	9	disease	disease	NOUN
ajst-32269	6	10	continuum	continuum	VERB
ajst-32269	6	11	"	"	PUNCT
ajst-32269	6	12	theory	theory	NOUN
ajst-32269	6	13	,	,	PUNCT
ajst-32269	6	14	biomarkers	biomarker	NOUN
ajst-32269	6	15	are	be	AUX
ajst-32269	6	16	classified	classify	VERB
ajst-32269	6	17	into	into	ADP
ajst-32269	6	18	three	three	NUM
ajst-32269	6	19	categories	category	NOUN
ajst-32269	6	20	:	:	PUNCT
ajst-32269	6	21	biomarkers	biomarker	NOUN
ajst-32269	6	22	of	of	ADP
ajst-32269	6	23	exposure	exposure	NOUN
ajst-32269	6	24	(	(	PUNCT
ajst-32269	6	25	e.g.	e.g.	ADV
ajst-32269	6	26	,	,	PUNCT
ajst-32269	6	27	cotinine	cotinine	NOUN
ajst-32269	6	28	for	for	ADP
ajst-32269	6	29	tobacco	tobacco	NOUN
ajst-32269	6	30	smoke	smoke	NOUN
ajst-32269	6	31	exposure	exposure	NOUN
ajst-32269	6	32	)	)	PUNCT
ajst-32269	6	33	,	,	PUNCT
ajst-32269	6	34	biomarkers	biomarker	NOUN
ajst-32269	6	35	of	of	ADP
ajst-32269	6	36	effect	effect	NOUN
ajst-32269	6	37	(	(	PUNCT
ajst-32269	6	38	e.g.	e.g.	ADV
ajst-32269	6	39	,	,	PUNCT
ajst-32269	6	40	8	8	NUM
ajst-32269	6	41	-	-	PUNCT
ajst-32269	6	42	ohdg	ohdg	NOUN
ajst-32269	6	43	indicating	indicate	VERB
ajst-32269	6	44	oxidative	oxidative	ADJ
ajst-32269	6	45	damage	damage	NOUN
ajst-32269	6	46	)	)	PUNCT
ajst-32269	6	47	,	,	PUNCT
ajst-32269	6	48	and	and	CCONJ
ajst-32269	6	49	biomarkers	biomarker	NOUN
ajst-32269	6	50	of	of	ADP
ajst-32269	6	51	susceptibility	susceptibility	NOUN
ajst-32269	6	52	(	(	PUNCT
ajst-32269	6	53	e.g.	e.g.	ADV
ajst-32269	6	54	,	,	PUNCT
ajst-32269	6	55	genetic	genetic	ADJ
ajst-32269	6	56	polymorphisms	polymorphism	NOUN
ajst-32269	6	57	)	)	PUNCT
ajst-32269	6	58	,	,	PUNCT
ajst-32269	6	59	alongside	alongside	ADP
ajst-32269	6	60	an	an	DET
ajst-32269	6	61	overview	overview	NOUN
ajst-32269	6	62	of	of	ADP
ajst-32269	6	63	their	their	PRON
ajst-32269	6	64	detection	detection	NOUN
ajst-32269	6	65	technologies	technology	NOUN
ajst-32269	6	66	.	.	PUNCT
ajst-32269	7	1	subsequently	subsequently	ADV
ajst-32269	7	2	,	,	PUNCT
ajst-32269	7	3	through	through	ADP
ajst-32269	7	4	analysis	analysis	NOUN
ajst-32269	7	5	of	of	ADP
ajst-32269	7	6	typical	typical	ADJ
ajst-32269	7	7	cases	case	NOUN
ajst-32269	7	8	involving	involve	VERB
ajst-32269	7	9	ambient	ambient	ADJ
ajst-32269	7	10	pm₂.₅	pm₂.₅	NOUN
ajst-32269	7	11	,	,	PUNCT
ajst-32269	7	12	heavy	heavy	ADJ
ajst-32269	7	13	metals	metal	NOUN
ajst-32269	7	14	,	,	PUNCT
ajst-32269	7	15	and	and	CCONJ
ajst-32269	7	16	environmental	environmental	ADJ
ajst-32269	7	17	endocrine	endocrine	NOUN
ajst-32269	7	18	disruptors	disruptor	NOUN
ajst-32269	7	19	(	(	PUNCT
ajst-32269	7	20	edcs	edc	NOUN
ajst-32269	7	21	)	)	PUNCT
ajst-32269	7	22	,	,	PUNCT
ajst-32269	7	23	the	the	DET
ajst-32269	7	24	specific	specific	ADJ
ajst-32269	7	25	applications	application	NOUN
ajst-32269	7	26	of	of	ADP
ajst-32269	7	27	various	various	ADJ
ajst-32269	7	28	biomarkers	biomarker	NOUN
ajst-32269	7	29	in	in	ADP
ajst-32269	7	30	revealing	reveal	VERB
ajst-32269	7	31	exposure	exposure	NOUN
ajst-32269	7	32	levels	level	NOUN
ajst-32269	7	33	,	,	PUNCT
ajst-32269	7	34	deciphering	decipher	VERB
ajst-32269	7	35	pathogenic	pathogenic	ADJ
ajst-32269	7	36	mechanisms	mechanism	NOUN
ajst-32269	7	37	,	,	PUNCT
ajst-32269	7	38	and	and	CCONJ
ajst-32269	7	39	assessing	assess	VERB
ajst-32269	7	40	health	health	NOUN
ajst-32269	7	41	risks	risk	NOUN
ajst-32269	7	42	are	be	AUX
ajst-32269	7	43	analyzed	analyze	VERB
ajst-32269	7	44	,	,	PUNCT
ajst-32269	7	45	demonstrating	demonstrate	VERB
ajst-32269	7	46	their	their	PRON
ajst-32269	7	47	core	core	NOUN
ajst-32269	7	48	value	value	NOUN
ajst-32269	7	49	in	in	ADP
ajst-32269	7	50	advancing	advance	VERB
ajst-32269	7	51	environmental	environmental	ADJ
ajst-32269	7	52	health	health	NOUN
ajst-32269	7	53	research	research	NOUN
ajst-32269	7	54	from	from	ADP
ajst-32269	7	55	macroscopic	macroscopic	ADJ
ajst-32269	7	56	associations	association	NOUN
ajst-32269	7	57	to	to	ADP
ajst-32269	7	58	microscopic	microscopic	ADJ
ajst-32269	7	59	mechanisms	mechanism	NOUN
ajst-32269	7	60	.	.	PUNCT
ajst-32269	8	1	finally	finally	ADV
ajst-32269	8	2	,	,	PUNCT
ajst-32269	8	3	the	the	DET
ajst-32269	8	4	article	article	NOUN
ajst-32269	8	5	discusses	discuss	VERB
ajst-32269	8	6	challenges	challenge	NOUN
ajst-32269	8	7	and	and	CCONJ
ajst-32269	8	8	limitations	limitation	NOUN
ajst-32269	8	9	concerning	concern	VERB
ajst-32269	8	10	technical	technical	ADJ
ajst-32269	8	11	standardization	standardization	NOUN
ajst-32269	8	12	,	,	PUNCT
ajst-32269	8	13	biological	biological	ADJ
ajst-32269	8	14	interpretation	interpretation	NOUN
ajst-32269	8	15	,	,	PUNCT
ajst-32269	8	16	translational	translational	ADJ
ajst-32269	8	17	application	application	NOUN
ajst-32269	8	18	,	,	PUNCT
ajst-32269	8	19	and	and	CCONJ
ajst-32269	8	20	assessment	assessment	NOUN
ajst-32269	8	21	of	of	ADP
ajst-32269	8	22	complex	complex	ADJ
ajst-32269	8	23	mixture	mixture	NOUN
ajst-32269	8	24	exposures	exposure	NOUN
ajst-32269	8	25	.	.	PUNCT
ajst-32269	9	1	it	it	PRON
ajst-32269	9	2	also	also	ADV
ajst-32269	9	3	offers	offer	VERB
ajst-32269	9	4	perspectives	perspective	NOUN
ajst-32269	9	5	on	on	ADP
ajst-32269	9	6	future	future	ADJ
ajst-32269	9	7	directions	direction	NOUN
ajst-32269	9	8	,	,	PUNCT
ajst-32269	9	9	including	include	VERB
ajst-32269	9	10	promoting	promote	VERB
ajst-32269	9	11	the	the	DET
ajst-32269	9	12	integration	integration	NOUN
ajst-32269	9	13	of	of	ADP
ajst-32269	9	14	multi	multi	ADJ
ajst-32269	9	15	-	-	ADJ
ajst-32269	9	16	omics	omics	ADJ
ajst-32269	9	17	technologies	technology	NOUN
ajst-32269	9	18	,	,	PUNCT
ajst-32269	9	19	strengthening	strengthen	VERB
ajst-32269	9	20	interdisciplinary	interdisciplinary	ADJ
ajst-32269	9	21	collaboration	collaboration	NOUN
ajst-32269	9	22	,	,	PUNCT
ajst-32269	9	23	and	and	CCONJ
ajst-32269	9	24	facilitating	facilitate	VERB
ajst-32269	9	25	the	the	DET
ajst-32269	9	26	translation	translation	NOUN
ajst-32269	9	27	of	of	ADP
ajst-32269	9	28	research	research	NOUN
ajst-32269	9	29	findings	finding	NOUN
ajst-32269	9	30	into	into	ADP
ajst-32269	9	31	public	public	ADJ
ajst-32269	9	32	health	health	NOUN
ajst-32269	9	33	practice	practice	NOUN
ajst-32269	9	34	,	,	PUNCT
ajst-32269	9	35	aiming	aim	VERB
ajst-32269	9	36	to	to	PART
ajst-32269	9	37	provide	provide	VERB
ajst-32269	9	38	a	a	DET
ajst-32269	9	39	scientific	scientific	ADJ
ajst-32269	9	40	basis	basis	NOUN
ajst-32269	9	41	for	for	ADP
ajst-32269	9	42	building	build	VERB
ajst-32269	9	43	a	a	DET
ajst-32269	9	44	precise	precise	ADJ
ajst-32269	9	45	environmental	environmental	ADJ
ajst-32269	9	46	health	health	NOUN
ajst-32269	9	47	risk	risk	NOUN
ajst-32269	9	48	assessment	assessment	NOUN
ajst-32269	9	49	and	and	CCONJ
ajst-32269	9	50	early	early	ADJ
ajst-32269	9	51	warning	warning	NOUN
ajst-32269	9	52	system	system	NOUN
ajst-32269	9	53	.	.	PUNCT
ajst-32269	10	1	keywords	keyword	NOUN
ajst-32269	10	2	:	:	PUNCT
ajst-32269	10	3	molecular	molecular	ADJ
ajst-32269	10	4	epidemiology	epidemiology	NOUN
ajst-32269	10	5	;	;	PUNCT
ajst-32269	10	6	biomarkers	biomarker	NOUN
ajst-32269	10	7	;	;	PUNCT
ajst-32269	10	8	environmental	environmental	ADJ
ajst-32269	10	9	exposure	exposure	NOUN
ajst-32269	10	10	;	;	PUNCT
ajst-32269	10	11	public	public	ADJ
ajst-32269	10	12	health	health	NOUN
ajst-32269	10	13	;	;	PUNCT
ajst-32269	10	14	precision	precision	NOUN
ajst-32269	10	15	prevention	prevention	NOUN
ajst-32269	10	16	.	.	PUNCT
ajst-32269	11	1	1	1	X
ajst-32269	11	2	.	.	X
ajst-32269	11	3	introduction	introduction	NOUN
ajst-32269	11	4	the	the	DET
ajst-32269	11	5	impact	impact	NOUN
ajst-32269	11	6	of	of	ADP
ajst-32269	11	7	environmental	environmental	ADJ
ajst-32269	11	8	factors	factor	NOUN
ajst-32269	11	9	on	on	ADP
ajst-32269	11	10	population	population	NOUN
ajst-32269	11	11	health	health	NOUN
ajst-32269	11	12	has	have	AUX
ajst-32269	11	13	long	long	ADV
ajst-32269	11	14	been	be	AUX
ajst-32269	11	15	a	a	DET
ajst-32269	11	16	crucial	crucial	ADJ
ajst-32269	11	17	area	area	NOUN
ajst-32269	11	18	of	of	ADP
ajst-32269	11	19	epidemiological	epidemiological	ADJ
ajst-32269	11	20	research	research	NOUN
ajst-32269	11	21	.	.	PUNCT
ajst-32269	12	1	traditional	traditional	ADJ
ajst-32269	12	2	epidemiological	epidemiological	ADJ
ajst-32269	12	3	studies	study	NOUN
ajst-32269	12	4	have	have	AUX
ajst-32269	12	5	provided	provide	VERB
ajst-32269	12	6	essential	essential	ADJ
ajst-32269	12	7	evidence	evidence	NOUN
ajst-32269	12	8	for	for	ADP
ajst-32269	12	9	public	public	ADJ
ajst-32269	12	10	health	health	NOUN
ajst-32269	12	11	policy	policy	NOUN
ajst-32269	12	12	formulation	formulation	NOUN
ajst-32269	12	13	by	by	ADP
ajst-32269	12	14	establishing	establish	VERB
ajst-32269	12	15	statistical	statistical	ADJ
ajst-32269	12	16	associations	association	NOUN
ajst-32269	12	17	between	between	ADP
ajst-32269	12	18	environmental	environmental	ADJ
ajst-32269	12	19	exposures	exposure	NOUN
ajst-32269	12	20	and	and	CCONJ
ajst-32269	12	21	disease	disease	NOUN
ajst-32269	12	22	occurrence	occurrence	NOUN
ajst-32269	12	23	.	.	PUNCT
ajst-32269	13	1	however	however	ADV
ajst-32269	13	2	,	,	PUNCT
ajst-32269	13	3	these	these	DET
ajst-32269	13	4	studies	study	NOUN
ajst-32269	13	5	exhibit	exhibit	VERB
ajst-32269	13	6	significant	significant	ADJ
ajst-32269	13	7	limitations	limitation	NOUN
ajst-32269	13	8	in	in	ADP
ajst-32269	13	9	accurately	accurately	ADV
ajst-32269	13	10	assessing	assess	VERB
ajst-32269	13	11	individual	individual	ADJ
ajst-32269	13	12	actual	actual	ADJ
ajst-32269	13	13	exposure	exposure	NOUN
ajst-32269	13	14	levels	level	NOUN
ajst-32269	13	15	,	,	PUNCT
ajst-32269	13	16	elucidating	elucidate	VERB
ajst-32269	13	17	biological	biological	ADJ
ajst-32269	13	18	mechanisms	mechanism	NOUN
ajst-32269	13	19	,	,	PUNCT
ajst-32269	13	20	and	and	CCONJ
ajst-32269	13	21	identifying	identify	VERB
ajst-32269	13	22	susceptible	susceptible	ADJ
ajst-32269	13	23	populations	population	NOUN
ajst-32269	13	24	,	,	PUNCT
ajst-32269	13	25	making	make	VERB
ajst-32269	13	26	it	it	PRON
ajst-32269	13	27	challenging	challenge	VERB
ajst-32269	13	28	to	to	PART
ajst-32269	13	29	meet	meet	VERB
ajst-32269	13	30	the	the	DET
ajst-32269	13	31	demands	demand	NOUN
ajst-32269	13	32	of	of	ADP
ajst-32269	13	33	precision	precision	NOUN
ajst-32269	13	34	public	public	ADJ
ajst-32269	13	35	health	health	NOUN
ajst-32269	13	36	prevention	prevention	NOUN
ajst-32269	13	37	and	and	CCONJ
ajst-32269	13	38	control	control	NOUN
ajst-32269	13	39	.	.	PUNCT
ajst-32269	14	1	the	the	DET
ajst-32269	14	2	rise	rise	NOUN
ajst-32269	14	3	of	of	ADP
ajst-32269	14	4	molecular	molecular	ADJ
ajst-32269	14	5	epidemiology	epidemiology	NOUN
ajst-32269	14	6	has	have	AUX
ajst-32269	14	7	brought	bring	VERB
ajst-32269	14	8	methodological	methodological	ADJ
ajst-32269	14	9	innovation	innovation	NOUN
ajst-32269	14	10	to	to	ADP
ajst-32269	14	11	environmental	environmental	ADJ
ajst-32269	14	12	health	health	NOUN
ajst-32269	14	13	research	research	NOUN
ajst-32269	14	14	.	.	PUNCT
ajst-32269	15	1	researchers	researcher	NOUN
ajst-32269	15	2	can	can	AUX
ajst-32269	15	3	bridge	bridge	VERB
ajst-32269	15	4	the	the	DET
ajst-32269	15	5	gap	gap	NOUN
ajst-32269	15	6	from	from	ADP
ajst-32269	15	7	macroscopic	macroscopic	ADJ
ajst-32269	15	8	associations	association	NOUN
ajst-32269	15	9	to	to	ADP
ajst-32269	15	10	microscopic	microscopic	ADJ
ajst-32269	15	11	mechanisms	mechanism	NOUN
ajst-32269	15	12	by	by	ADP
ajst-32269	15	13	detecting	detect	VERB
ajst-32269	15	14	specific	specific	ADJ
ajst-32269	15	15	biomarkers	biomarker	NOUN
ajst-32269	15	16	.	.	PUNCT
ajst-32269	16	1	biomarkers	biomarker	NOUN
ajst-32269	16	2	of	of	ADP
ajst-32269	16	3	internal	internal	ADJ
ajst-32269	16	4	exposure	exposure	NOUN
ajst-32269	16	5	(	(	PUNCT
ajst-32269	16	6	e.g.	e.g.	ADV
ajst-32269	16	7	,	,	PUNCT
ajst-32269	16	8	urinary	urinary	ADJ
ajst-32269	16	9	tobacco	tobacco	NOUN
ajst-32269	16	10	metabolite	metabolite	NOUN
ajst-32269	16	11	cotinine	cotinine	NOUN
ajst-32269	16	12	,	,	PUNCT
ajst-32269	16	13	blood	blood	NOUN
ajst-32269	16	14	heavy	heavy	ADJ
ajst-32269	16	15	metal	metal	NOUN
ajst-32269	16	16	concentrations	concentration	NOUN
ajst-32269	16	17	)	)	PUNCT
ajst-32269	16	18	directly	directly	ADV
ajst-32269	16	19	reflect	reflect	VERB
ajst-32269	16	20	the	the	DET
ajst-32269	16	21	actual	actual	ADJ
ajst-32269	16	22	absorbed	absorb	VERB
ajst-32269	16	23	dose	dose	VERB
ajst-32269	16	24	by	by	ADP
ajst-32269	16	25	the	the	DET
ajst-32269	16	26	organism	organism	NOUN
ajst-32269	16	27	,	,	PUNCT
ajst-32269	16	28	addressing	address	VERB
ajst-32269	16	29	the	the	DET
ajst-32269	16	30	significant	significant	ADJ
ajst-32269	16	31	errors	error	NOUN
ajst-32269	16	32	in	in	ADP
ajst-32269	16	33	traditional	traditional	ADJ
ajst-32269	16	34	exposure	exposure	NOUN
ajst-32269	16	35	assessment	assessment	NOUN
ajst-32269	16	36	[	[	X
ajst-32269	16	37	1	1	NUM
ajst-32269	16	38	]	]	PUNCT
ajst-32269	16	39	.	.	PUNCT
ajst-32269	17	1	biomarkers	biomarker	NOUN
ajst-32269	17	2	of	of	ADP
ajst-32269	17	3	effect	effect	NOUN
ajst-32269	17	4	(	(	PUNCT
ajst-32269	17	5	e.g.	e.g.	ADV
ajst-32269	17	6	,	,	PUNCT
ajst-32269	17	7	dna	dna	NOUN
ajst-32269	17	8	adducts	adduct	NOUN
ajst-32269	17	9	,	,	PUNCT
ajst-32269	17	10	oxidative	oxidative	ADJ
ajst-32269	17	11	stress	stress	NOUN
ajst-32269	17	12	product	product	NOUN
ajst-32269	17	13	8	8	NUM
ajst-32269	17	14	-	-	SYM
ajst-32269	17	15	ohdg	ohdg	VERB
ajst-32269	17	16	,	,	PUNCT
ajst-32269	17	17	epigenetic	epigenetic	ADJ
ajst-32269	17	18	changes	change	NOUN
ajst-32269	17	19	)	)	PUNCT
ajst-32269	17	20	provide	provide	VERB
ajst-32269	17	21	mechanistic	mechanistic	ADJ
ajst-32269	17	22	evidence	evidence	NOUN
ajst-32269	17	23	for	for	ADP
ajst-32269	17	24	exposure	exposure	NOUN
ajst-32269	17	25	-	-	PUNCT
ajst-32269	17	26	disease	disease	NOUN
ajst-32269	17	27	associations	association	NOUN
ajst-32269	17	28	[	[	X
ajst-32269	17	29	2	2	NUM
ajst-32269	17	30	]	]	PUNCT
ajst-32269	17	31	.	.	PUNCT
ajst-32269	18	1	biomarkers	biomarker	NOUN
ajst-32269	18	2	of	of	ADP
ajst-32269	18	3	susceptibility	susceptibility	NOUN
ajst-32269	18	4	(	(	PUNCT
ajst-32269	18	5	e.g.	e.g.	ADV
ajst-32269	18	6	,	,	PUNCT
ajst-32269	18	7	metabolic	metabolic	ADJ
ajst-32269	18	8	enzyme	enzyme	NOUN
ajst-32269	18	9	gene	gene	NOUN
ajst-32269	18	10	polymorphisms	polymorphism	NOUN
ajst-32269	18	11	)	)	PUNCT
ajst-32269	18	12	help	help	VERB
ajst-32269	18	13	explain	explain	VERB
ajst-32269	18	14	individual	individual	ADJ
ajst-32269	18	15	differences	difference	NOUN
ajst-32269	18	16	within	within	ADP
ajst-32269	18	17	populations	population	NOUN
ajst-32269	18	18	.	.	PUNCT
ajst-32269	19	1	the	the	DET
ajst-32269	19	2	application	application	NOUN
ajst-32269	19	3	of	of	ADP
ajst-32269	19	4	these	these	DET
ajst-32269	19	5	biomarkers	biomarker	NOUN
ajst-32269	19	6	enables	enable	VERB
ajst-32269	19	7	environmental	environmental	ADJ
ajst-32269	19	8	epidemiology	epidemiology	NOUN
ajst-32269	19	9	research	research	NOUN
ajst-32269	19	10	to	to	PART
ajst-32269	19	11	delve	delve	VERB
ajst-32269	19	12	deeply	deeply	ADV
ajst-32269	19	13	into	into	ADP
ajst-32269	19	14	the	the	DET
ajst-32269	19	15	"	"	PUNCT
ajst-32269	19	16	black	black	ADJ
ajst-32269	19	17	box	box	NOUN
ajst-32269	19	18	"	"	PUNCT
ajst-32269	19	19	mechanism	mechanism	NOUN
ajst-32269	19	20	.	.	PUNCT
ajst-32269	20	1	currently	currently	ADV
ajst-32269	20	2	,	,	PUNCT
ajst-32269	20	3	a	a	DET
ajst-32269	20	4	major	major	ADJ
ajst-32269	20	5	challenge	challenge	NOUN
ajst-32269	20	6	in	in	ADP
ajst-32269	20	7	this	this	DET
ajst-32269	20	8	field	field	NOUN
ajst-32269	20	9	lies	lie	VERB
ajst-32269	20	10	in	in	ADP
ajst-32269	20	11	translating	translate	VERB
ajst-32269	20	12	laboratory	laboratory	NOUN
ajst-32269	20	13	-	-	PUNCT
ajst-32269	20	14	discovered	discover	VERB
ajst-32269	20	15	biomarkers	biomarker	NOUN
ajst-32269	20	16	into	into	ADP
ajst-32269	20	17	tools	tool	NOUN
ajst-32269	20	18	suitable	suitable	ADJ
ajst-32269	20	19	for	for	ADP
ajst-32269	20	20	large	large	ADJ
ajst-32269	20	21	-	-	PUNCT
ajst-32269	20	22	scale	scale	NOUN
ajst-32269	20	23	population	population	NOUN
ajst-32269	20	24	studies	study	NOUN
ajst-32269	20	25	and	and	CCONJ
ajst-32269	20	26	ultimately	ultimately	ADV
ajst-32269	20	27	applying	apply	VERB
ajst-32269	20	28	them	they	PRON
ajst-32269	20	29	in	in	ADP
ajst-32269	20	30	public	public	ADJ
ajst-32269	20	31	health	health	NOUN
ajst-32269	20	32	practice	practice	NOUN
ajst-32269	20	33	.	.	PUNCT
ajst-32269	21	1	59	59	NUM
ajst-32269	21	2	from	from	ADP
ajst-32269	21	3	the	the	DET
ajst-32269	21	4	molecular	molecular	ADJ
ajst-32269	21	5	epidemiology	epidemiology	NOUN
ajst-32269	21	6	perspective	perspective	NOUN
ajst-32269	21	7	,	,	PUNCT
ajst-32269	21	8	this	this	DET
ajst-32269	21	9	article	article	NOUN
ajst-32269	21	10	systematically	systematically	ADV
ajst-32269	21	11	reviews	review	VERB
ajst-32269	21	12	the	the	DET
ajst-32269	21	13	progress	progress	NOUN
ajst-32269	21	14	in	in	ADP
ajst-32269	21	15	biomarkers	biomarker	NOUN
ajst-32269	21	16	for	for	ADP
ajst-32269	21	17	environmental	environmental	ADJ
ajst-32269	21	18	health	health	NOUN
ajst-32269	21	19	research	research	NOUN
ajst-32269	21	20	,	,	PUNCT
ajst-32269	21	21	focusing	focus	VERB
ajst-32269	21	22	on	on	ADP
ajst-32269	21	23	their	their	PRON
ajst-32269	21	24	applications	application	NOUN
ajst-32269	21	25	in	in	ADP
ajst-32269	21	26	exposure	exposure	NOUN
ajst-32269	21	27	assessment	assessment	NOUN
ajst-32269	21	28	,	,	PUNCT
ajst-32269	21	29	health	health	NOUN
ajst-32269	21	30	risk	risk	NOUN
ajst-32269	21	31	early	early	ADJ
ajst-32269	21	32	warning	warning	NOUN
ajst-32269	21	33	,	,	PUNCT
ajst-32269	21	34	and	and	CCONJ
ajst-32269	21	35	precision	precision	NOUN
ajst-32269	21	36	prevention	prevention	NOUN
ajst-32269	21	37	,	,	PUNCT
ajst-32269	21	38	to	to	PART
ajst-32269	21	39	provide	provide	VERB
ajst-32269	21	40	a	a	DET
ajst-32269	21	41	scientific	scientific	ADJ
ajst-32269	21	42	basis	basis	NOUN
ajst-32269	21	43	for	for	ADP
ajst-32269	21	44	advancing	advance	VERB
ajst-32269	21	45	the	the	DET
ajst-32269	21	46	precise	precise	ADJ
ajst-32269	21	47	prevention	prevention	NOUN
ajst-32269	21	48	and	and	CCONJ
ajst-32269	21	49	control	control	NOUN
ajst-32269	21	50	of	of	ADP
ajst-32269	21	51	environment	environment	NOUN
ajst-32269	21	52	-	-	PUNCT
ajst-32269	21	53	related	relate	VERB
ajst-32269	21	54	diseases	disease	NOUN
ajst-32269	21	55	.	.	PUNCT
ajst-32269	22	1	2	2	X
ajst-32269	22	2	.	.	X
ajst-32269	22	3	molecular	molecular	ADJ
ajst-32269	22	4	biomarkers	biomarker	NOUN
ajst-32269	22	5	technology	technology	NOUN
ajst-32269	22	6	molecular	molecular	ADJ
ajst-32269	22	7	biomarkers	biomarker	NOUN
ajst-32269	22	8	are	be	AUX
ajst-32269	22	9	core	core	NOUN
ajst-32269	22	10	tools	tool	NOUN
ajst-32269	22	11	in	in	ADP
ajst-32269	22	12	modern	modern	ADJ
ajst-32269	22	13	environmental	environmental	ADJ
ajst-32269	22	14	health	health	NOUN
ajst-32269	22	15	research	research	NOUN
ajst-32269	22	16	.	.	PUNCT
ajst-32269	23	1	as	as	ADP
ajst-32269	23	2	a	a	DET
ajst-32269	23	3	critical	critical	ADJ
ajst-32269	23	4	bridge	bridge	NOUN
ajst-32269	23	5	connecting	connect	VERB
ajst-32269	23	6	environmental	environmental	ADJ
ajst-32269	23	7	exposure	exposure	NOUN
ajst-32269	23	8	and	and	CCONJ
ajst-32269	23	9	health	health	NOUN
ajst-32269	23	10	effects	effect	NOUN
ajst-32269	23	11	,	,	PUNCT
ajst-32269	23	12	their	their	PRON
ajst-32269	23	13	scientific	scientific	ADJ
ajst-32269	23	14	classification	classification	NOUN
ajst-32269	23	15	and	and	CCONJ
ajst-32269	23	16	precise	precise	ADJ
ajst-32269	23	17	detection	detection	NOUN
ajst-32269	23	18	methods	method	NOUN
ajst-32269	23	19	are	be	AUX
ajst-32269	23	20	the	the	DET
ajst-32269	23	21	cornerstones	cornerstone	NOUN
ajst-32269	23	22	of	of	ADP
ajst-32269	23	23	molecular	molecular	ADJ
ajst-32269	23	24	epidemiological	epidemiological	ADJ
ajst-32269	23	25	research	research	NOUN
ajst-32269	23	26	.	.	PUNCT
ajst-32269	24	1	based	base	VERB
ajst-32269	24	2	on	on	ADP
ajst-32269	24	3	their	their	PRON
ajst-32269	24	4	indicated	indicate	VERB
ajst-32269	24	5	biological	biological	ADJ
ajst-32269	24	6	stage	stage	NOUN
ajst-32269	24	7	and	and	CCONJ
ajst-32269	24	8	functional	functional	ADJ
ajst-32269	24	9	significance	significance	NOUN
ajst-32269	24	10	in	in	ADP
ajst-32269	24	11	the	the	DET
ajst-32269	24	12	"	"	PUNCT
ajst-32269	24	13	exposure	exposure	NOUN
ajst-32269	24	14	-	-	PUNCT
ajst-32269	24	15	disease	disease	NOUN
ajst-32269	24	16	continuum	continuum	VERB
ajst-32269	24	17	,	,	PUNCT
ajst-32269	24	18	"	"	PUNCT
ajst-32269	24	19	molecular	molecular	ADJ
ajst-32269	24	20	biomarkers	biomarker	NOUN
ajst-32269	24	21	can	can	AUX
ajst-32269	24	22	be	be	AUX
ajst-32269	24	23	divided	divide	VERB
ajst-32269	24	24	into	into	ADP
ajst-32269	24	25	three	three	NUM
ajst-32269	24	26	major	major	ADJ
ajst-32269	24	27	categories	category	NOUN
ajst-32269	24	28	:	:	PUNCT
ajst-32269	24	29	biomarkers	biomarker	NOUN
ajst-32269	24	30	of	of	ADP
ajst-32269	24	31	exposure	exposure	NOUN
ajst-32269	24	32	,	,	PUNCT
ajst-32269	24	33	biomarkers	biomarker	NOUN
ajst-32269	24	34	of	of	ADP
ajst-32269	24	35	effect	effect	NOUN
ajst-32269	24	36	,	,	PUNCT
ajst-32269	24	37	and	and	CCONJ
ajst-32269	24	38	biomarkers	biomarker	NOUN
ajst-32269	24	39	of	of	ADP
ajst-32269	24	40	susceptibility	susceptibility	NOUN
ajst-32269	24	41	.	.	PUNCT
ajst-32269	25	1	these	these	DET
ajst-32269	25	2	biomarkers	biomarker	NOUN
ajst-32269	25	3	help	help	VERB
ajst-32269	25	4	us	we	PRON
ajst-32269	25	5	understand	understand	VERB
ajst-32269	25	6	the	the	DET
ajst-32269	25	7	biological	biological	ADJ
ajst-32269	25	8	mechanisms	mechanism	NOUN
ajst-32269	25	9	between	between	ADP
ajst-32269	25	10	environmental	environmental	ADJ
ajst-32269	25	11	exposure	exposure	NOUN
ajst-32269	25	12	and	and	CCONJ
ajst-32269	25	13	health	health	NOUN
ajst-32269	25	14	outcomes	outcome	NOUN
ajst-32269	25	15	and	and	CCONJ
ajst-32269	25	16	provide	provide	VERB
ajst-32269	25	17	scientific	scientific	ADJ
ajst-32269	25	18	evidence	evidence	NOUN
ajst-32269	25	19	for	for	ADP
ajst-32269	25	20	public	public	ADJ
ajst-32269	25	21	health	health	NOUN
ajst-32269	25	22	interventions	intervention	NOUN
ajst-32269	25	23	.	.	PUNCT
ajst-32269	26	1	2.1	2.1	NUM
ajst-32269	26	2	biomarkers	biomarker	NOUN
ajst-32269	26	3	of	of	ADP
ajst-32269	26	4	exposure	exposure	NOUN
ajst-32269	26	5	biomarkers	biomarker	NOUN
ajst-32269	26	6	of	of	ADP
ajst-32269	26	7	exposure	exposure	NOUN
ajst-32269	26	8	refer	refer	VERB
ajst-32269	26	9	to	to	ADP
ajst-32269	26	10	biological	biological	ADJ
ajst-32269	26	11	indicators	indicator	NOUN
ajst-32269	26	12	that	that	PRON
ajst-32269	26	13	can	can	AUX
ajst-32269	26	14	directly	directly	ADV
ajst-32269	26	15	and	and	CCONJ
ajst-32269	26	16	specifically	specifically	ADV
ajst-32269	26	17	reflect	reflect	VERB
ajst-32269	26	18	an	an	DET
ajst-32269	26	19	organism	organism	NOUN
ajst-32269	26	20	's	's	PART
ajst-32269	26	21	level	level	NOUN
ajst-32269	26	22	of	of	ADP
ajst-32269	26	23	contact	contact	NOUN
ajst-32269	26	24	with	with	ADP
ajst-32269	26	25	environmental	environmental	ADJ
ajst-32269	26	26	harmful	harmful	ADJ
ajst-32269	26	27	factors	factor	NOUN
ajst-32269	26	28	.	.	PUNCT
ajst-32269	27	1	these	these	DET
ajst-32269	27	2	biomarkers	biomarker	NOUN
ajst-32269	27	3	include	include	VERB
ajst-32269	27	4	the	the	DET
ajst-32269	27	5	exogenous	exogenous	ADJ
ajst-32269	27	6	substances	substance	NOUN
ajst-32269	27	7	themselves	themselves	PRON
ajst-32269	27	8	,	,	PUNCT
ajst-32269	27	9	their	their	PRON
ajst-32269	27	10	metabolites	metabolite	NOUN
ajst-32269	27	11	,	,	PUNCT
ajst-32269	27	12	or	or	CCONJ
ajst-32269	27	13	adducts	adduct	NOUN
ajst-32269	27	14	formed	form	VERB
ajst-32269	27	15	with	with	ADP
ajst-32269	27	16	biological	biological	ADJ
ajst-32269	27	17	macromolecules	macromolecule	NOUN
ajst-32269	27	18	.	.	PUNCT
ajst-32269	28	1	compared	compare	VERB
ajst-32269	28	2	to	to	ADP
ajst-32269	28	3	traditional	traditional	ADJ
ajst-32269	28	4	environmental	environmental	ADJ
ajst-32269	28	5	monitoring	monitoring	NOUN
ajst-32269	28	6	methods	method	NOUN
ajst-32269	28	7	,	,	PUNCT
ajst-32269	28	8	biomarkers	biomarker	NOUN
ajst-32269	28	9	of	of	ADP
ajst-32269	28	10	exposure	exposure	NOUN
ajst-32269	28	11	provide	provide	VERB
ajst-32269	28	12	direct	direct	ADJ
ajst-32269	28	13	evidence	evidence	NOUN
ajst-32269	28	14	of	of	ADP
ajst-32269	28	15	an	an	DET
ajst-32269	28	16	individual	individual	NOUN
ajst-32269	28	17	's	's	PART
ajst-32269	28	18	exposure	exposure	NOUN
ajst-32269	28	19	dose	dose	NOUN
ajst-32269	28	20	,	,	PUNCT
ajst-32269	28	21	avoiding	avoid	VERB
ajst-32269	28	22	potential	potential	ADJ
ajst-32269	28	23	error	error	NOUN
ajst-32269	28	24	sources	source	NOUN
ajst-32269	28	25	in	in	ADP
ajst-32269	28	26	external	external	ADJ
ajst-32269	28	27	exposure	exposure	NOUN
ajst-32269	28	28	assessment	assessment	NOUN
ajst-32269	28	29	such	such	ADJ
ajst-32269	28	30	as	as	ADP
ajst-32269	28	31	geographical	geographical	ADJ
ajst-32269	28	32	differences	difference	NOUN
ajst-32269	28	33	,	,	PUNCT
ajst-32269	28	34	temporal	temporal	ADJ
ajst-32269	28	35	variations	variation	NOUN
ajst-32269	28	36	,	,	PUNCT
ajst-32269	28	37	and	and	CCONJ
ajst-32269	28	38	personal	personal	ADJ
ajst-32269	28	39	behavioral	behavioral	ADJ
ajst-32269	28	40	differences	difference	NOUN
ajst-32269	28	41	.	.	PUNCT
ajst-32269	29	1	many	many	ADJ
ajst-32269	29	2	biomarkers	biomarker	NOUN
ajst-32269	29	3	of	of	ADP
ajst-32269	29	4	exposure	exposure	NOUN
ajst-32269	29	5	have	have	AUX
ajst-32269	29	6	already	already	ADV
ajst-32269	29	7	been	be	AUX
ajst-32269	29	8	applied	apply	VERB
ajst-32269	29	9	in	in	ADP
ajst-32269	29	10	public	public	ADJ
ajst-32269	29	11	health	health	NOUN
ajst-32269	29	12	research	research	NOUN
ajst-32269	29	13	.	.	PUNCT
ajst-32269	30	1	cotinine	cotinine	NOUN
ajst-32269	30	2	,	,	PUNCT
ajst-32269	30	3	as	as	ADP
ajst-32269	30	4	the	the	DET
ajst-32269	30	5	primary	primary	ADJ
ajst-32269	30	6	metabolite	metabolite	NOUN
ajst-32269	30	7	of	of	ADP
ajst-32269	30	8	nicotine	nicotine	NOUN
ajst-32269	30	9	in	in	ADP
ajst-32269	30	10	the	the	DET
ajst-32269	30	11	human	human	ADJ
ajst-32269	30	12	body	body	NOUN
ajst-32269	30	13	,	,	PUNCT
ajst-32269	30	14	is	be	AUX
ajst-32269	30	15	the	the	DET
ajst-32269	30	16	most	most	ADV
ajst-32269	30	17	specific	specific	ADJ
ajst-32269	30	18	and	and	CCONJ
ajst-32269	30	19	reliable	reliable	ADJ
ajst-32269	30	20	biomarker	biomarker	NOUN
ajst-32269	30	21	of	of	ADP
ajst-32269	30	22	internal	internal	ADJ
ajst-32269	30	23	exposure	exposure	NOUN
ajst-32269	30	24	for	for	ADP
ajst-32269	30	25	assessing	assess	VERB
ajst-32269	30	26	tobacco	tobacco	NOUN
ajst-32269	30	27	smoke	smoke	NOUN
ajst-32269	30	28	exposure	exposure	NOUN
ajst-32269	30	29	.	.	PUNCT
ajst-32269	31	1	its	its	PRON
ajst-32269	31	2	biological	biological	ADJ
ajst-32269	31	3	properties	property	NOUN
ajst-32269	31	4	make	make	VERB
ajst-32269	31	5	it	it	PRON
ajst-32269	31	6	an	an	DET
ajst-32269	31	7	ideal	ideal	ADJ
ajst-32269	31	8	biomarker	biomarker	NOUN
ajst-32269	31	9	of	of	ADP
ajst-32269	31	10	exposure	exposure	NOUN
ajst-32269	31	11	:	:	PUNCT
ajst-32269	31	12	a	a	DET
ajst-32269	31	13	moderate	moderate	ADJ
ajst-32269	31	14	half	half	ADJ
ajst-32269	31	15	-	-	PUNCT
ajst-32269	31	16	life	life	NOUN
ajst-32269	31	17	(	(	PUNCT
ajst-32269	31	18	16	16	NUM
ajst-32269	31	19	-	-	SYM
ajst-32269	31	20	20	20	NUM
ajst-32269	31	21	hours	hour	NOUN
ajst-32269	31	22	)	)	PUNCT
ajst-32269	31	23	allows	allow	VERB
ajst-32269	31	24	it	it	PRON
ajst-32269	31	25	to	to	PART
ajst-32269	31	26	reflect	reflect	VERB
ajst-32269	31	27	an	an	DET
ajst-32269	31	28	individual	individual	NOUN
ajst-32269	31	29	's	's	PART
ajst-32269	31	30	tobacco	tobacco	NOUN
ajst-32269	31	31	smoke	smoke	NOUN
ajst-32269	31	32	exposure	exposure	NOUN
ajst-32269	31	33	over	over	ADP
ajst-32269	31	34	the	the	DET
ajst-32269	31	35	past	past	ADJ
ajst-32269	31	36	few	few	ADJ
ajst-32269	31	37	days	day	NOUN
ajst-32269	31	38	;	;	PUNCT
ajst-32269	31	39	stable	stable	ADJ
ajst-32269	31	40	chemical	chemical	NOUN
ajst-32269	31	41	properties	property	NOUN
ajst-32269	31	42	make	make	VERB
ajst-32269	31	43	it	it	PRON
ajst-32269	31	44	easy	easy	ADJ
ajst-32269	31	45	to	to	PART
ajst-32269	31	46	detect	detect	VERB
ajst-32269	31	47	in	in	ADP
ajst-32269	31	48	biological	biological	ADJ
ajst-32269	31	49	samples	sample	NOUN
ajst-32269	31	50	;	;	PUNCT
ajst-32269	31	51	and	and	CCONJ
ajst-32269	31	52	its	its	PRON
ajst-32269	31	53	concentration	concentration	NOUN
ajst-32269	31	54	shows	show	VERB
ajst-32269	31	55	a	a	DET
ajst-32269	31	56	good	good	ADJ
ajst-32269	31	57	dose	dose	NOUN
ajst-32269	31	58	-	-	PUNCT
ajst-32269	31	59	response	response	NOUN
ajst-32269	31	60	relationship	relationship	NOUN
ajst-32269	31	61	with	with	ADP
ajst-32269	31	62	exposure	exposure	NOUN
ajst-32269	31	63	dose	dose	PROPN
ajst-32269	31	64	.	.	PUNCT
ajst-32269	32	1	the	the	DET
ajst-32269	32	2	detection	detection	NOUN
ajst-32269	32	3	of	of	ADP
ajst-32269	32	4	cotinine	cotinine	NOUN
ajst-32269	32	5	primarily	primarily	ADV
ajst-32269	32	6	relies	rely	VERB
ajst-32269	32	7	on	on	ADP
ajst-32269	32	8	immunological	immunological	ADJ
ajst-32269	32	9	methods	method	NOUN
ajst-32269	32	10	(	(	PUNCT
ajst-32269	32	11	e.g.	e.g.	ADV
ajst-32269	32	12	,	,	PUNCT
ajst-32269	32	13	enzyme	enzyme	NOUN
ajst-32269	32	14	-	-	PUNCT
ajst-32269	32	15	linked	link	VERB
ajst-32269	32	16	immunosorbent	immunosorbent	NOUN
ajst-32269	32	17	assay	assay	NOUN
ajst-32269	32	18	,	,	PUNCT
ajst-32269	32	19	elisa	elisa	NOUN
ajst-32269	32	20	)	)	PUNCT
ajst-32269	33	1	[	[	X
ajst-32269	33	2	3	3	NUM
ajst-32269	33	3	]	]	PUNCT
ajst-32269	33	4	and	and	CCONJ
ajst-32269	33	5	chromatographic	chromatographic	ADJ
ajst-32269	33	6	techniques	technique	NOUN
ajst-32269	33	7	.	.	PUNCT
ajst-32269	34	1	nowadays	nowadays	ADV
ajst-32269	34	2	,	,	PUNCT
ajst-32269	34	3	high	high	ADJ
ajst-32269	34	4	-	-	PUNCT
ajst-32269	34	5	sensitivity	sensitivity	NOUN
ajst-32269	34	6	and	and	CCONJ
ajst-32269	34	7	high	high	ADJ
ajst-32269	34	8	-	-	PUNCT
ajst-32269	34	9	specificity	specificity	NOUN
ajst-32269	34	10	analytical	analytical	ADJ
ajst-32269	34	11	techniques	technique	NOUN
ajst-32269	34	12	such	such	ADJ
ajst-32269	34	13	as	as	ADP
ajst-32269	34	14	liquid	liquid	ADJ
ajst-32269	34	15	chromatography	chromatography	NOUN
ajst-32269	34	16	-	-	PUNCT
ajst-32269	34	17	tandem	tandem	NOUN
ajst-32269	34	18	mass	mass	ADJ
ajst-32269	34	19	spectrometry	spectrometry	NOUN
ajst-32269	34	20	(	(	PUNCT
ajst-32269	34	21	lc	lc	PROPN
ajst-32269	34	22	-	-	PUNCT
ajst-32269	34	23	ms	ms	PROPN
ajst-32269	34	24	/	/	SYM
ajst-32269	34	25	ms	ms	NOUN
ajst-32269	34	26	)	)	PUNCT
ajst-32269	35	1	[	[	X
ajst-32269	35	2	4	4	X
ajst-32269	35	3	]	]	PUNCT
ajst-32269	35	4	and	and	CCONJ
ajst-32269	35	5	gas	gas	NOUN
ajst-32269	35	6	chromatography	chromatography	NOUN
ajst-32269	35	7	-	-	PUNCT
ajst-32269	35	8	mass	mass	NOUN
ajst-32269	35	9	spectrometry	spectrometry	NOUN
ajst-32269	35	10	(	(	PUNCT
ajst-32269	35	11	gc	gc	PROPN
ajst-32269	35	12	-	-	PUNCT
ajst-32269	35	13	ms	ms	NOUN
ajst-32269	35	14	)	)	PUNCT
ajst-32269	35	15	[	[	X
ajst-32269	35	16	5	5	NUM
ajst-32269	35	17	]	]	PUNCT
ajst-32269	35	18	are	be	AUX
ajst-32269	35	19	widely	widely	ADV
ajst-32269	35	20	used	use	VERB
ajst-32269	35	21	.	.	PUNCT
ajst-32269	36	1	the	the	DET
ajst-32269	36	2	development	development	NOUN
ajst-32269	36	3	of	of	ADP
ajst-32269	36	4	these	these	DET
ajst-32269	36	5	technologies	technology	NOUN
ajst-32269	36	6	has	have	AUX
ajst-32269	36	7	greatly	greatly	ADV
ajst-32269	36	8	improved	improve	VERB
ajst-32269	36	9	detection	detection	NOUN
ajst-32269	36	10	accuracy	accuracy	NOUN
ajst-32269	36	11	and	and	CCONJ
ajst-32269	36	12	throughput	throughput	NOUN
ajst-32269	36	13	,	,	PUNCT
ajst-32269	36	14	enabling	enable	VERB
ajst-32269	36	15	large	large	ADJ
ajst-32269	36	16	-	-	PUNCT
ajst-32269	36	17	scale	scale	NOUN
ajst-32269	36	18	biomonitoring	biomonitoring	NOUN
ajst-32269	36	19	studies	study	NOUN
ajst-32269	36	20	at	at	ADP
ajst-32269	36	21	the	the	DET
ajst-32269	36	22	population	population	NOUN
ajst-32269	36	23	level	level	NOUN
ajst-32269	36	24	.	.	PUNCT
ajst-32269	37	1	lc	lc	PROPN
ajst-32269	37	2	-	-	PUNCT
ajst-32269	37	3	ms	ms	PROPN
ajst-32269	37	4	/	/	SYM
ajst-32269	37	5	ms	ms	PROPN
ajst-32269	37	6	technology	technology	NOUN
ajst-32269	37	7	is	be	AUX
ajst-32269	37	8	commonly	commonly	ADV
ajst-32269	37	9	used	use	VERB
ajst-32269	37	10	for	for	ADP
ajst-32269	37	11	cotinine	cotinine	NOUN
ajst-32269	37	12	detection	detection	NOUN
ajst-32269	37	13	in	in	ADP
ajst-32269	37	14	practical	practical	ADJ
ajst-32269	37	15	applications	application	NOUN
ajst-32269	37	16	.	.	PUNCT
ajst-32269	38	1	this	this	DET
ajst-32269	38	2	technique	technique	NOUN
ajst-32269	38	3	features	feature	VERB
ajst-32269	38	4	high	high	ADJ
ajst-32269	38	5	sensitivity	sensitivity	NOUN
ajst-32269	38	6	(	(	PUNCT
ajst-32269	38	7	detection	detection	NOUN
ajst-32269	38	8	limit	limit	NOUN
ajst-32269	38	9	can	can	AUX
ajst-32269	38	10	reach	reach	VERB
ajst-32269	38	11	0.1	0.1	NUM
ajst-32269	38	12	ng	ng	NOUN
ajst-32269	38	13	/	/	SYM
ajst-32269	38	14	ml	ml	NOUN
ajst-32269	38	15	)	)	PUNCT
ajst-32269	38	16	and	and	CCONJ
ajst-32269	38	17	high	high	ADJ
ajst-32269	38	18	specificity	specificity	NOUN
ajst-32269	38	19	,	,	PUNCT
ajst-32269	38	20	allowing	allow	VERB
ajst-32269	38	21	accurate	accurate	ADJ
ajst-32269	38	22	determination	determination	NOUN
ajst-32269	38	23	of	of	ADP
ajst-32269	38	24	cotinine	cotinine	NOUN
ajst-32269	38	25	concentration	concentration	NOUN
ajst-32269	38	26	in	in	ADP
ajst-32269	38	27	urine	urine	NOUN
ajst-32269	38	28	,	,	PUNCT
ajst-32269	38	29	blood	blood	NOUN
ajst-32269	38	30	,	,	PUNCT
ajst-32269	38	31	or	or	CCONJ
ajst-32269	38	32	saliva	saliva	NOUN
ajst-32269	38	33	[	[	X
ajst-32269	38	34	6	6	NUM
ajst-32269	38	35	]	]	PUNCT
ajst-32269	38	36	.	.	PUNCT
ajst-32269	39	1	the	the	DET
ajst-32269	39	2	detection	detection	NOUN
ajst-32269	39	3	of	of	ADP
ajst-32269	39	4	cotinine	cotinine	NOUN
ajst-32269	39	5	provides	provide	VERB
ajst-32269	39	6	a	a	DET
ajst-32269	39	7	precise	precise	ADJ
ajst-32269	39	8	exposure	exposure	NOUN
ajst-32269	39	9	assessment	assessment	NOUN
ajst-32269	39	10	foundation	foundation	NOUN
ajst-32269	39	11	for	for	ADP
ajst-32269	39	12	studying	study	VERB
ajst-32269	39	13	the	the	DET
ajst-32269	39	14	health	health	NOUN
ajst-32269	39	15	effects	effect	NOUN
ajst-32269	39	16	of	of	ADP
ajst-32269	39	17	tobacco	tobacco	NOUN
ajst-32269	39	18	smoke	smoke	NOUN
ajst-32269	39	19	,	,	PUNCT
ajst-32269	39	20	enabling	enable	VERB
ajst-32269	39	21	researchers	researcher	NOUN
ajst-32269	39	22	to	to	PART
ajst-32269	39	23	establish	establish	VERB
ajst-32269	39	24	more	more	ADV
ajst-32269	39	25	accurate	accurate	ADJ
ajst-32269	39	26	dose	dose	NOUN
ajst-32269	39	27	-	-	PUNCT
ajst-32269	39	28	response	response	NOUN
ajst-32269	39	29	relationship	relationship	NOUN
ajst-32269	39	30	models	model	NOUN
ajst-32269	39	31	.	.	PUNCT
ajst-32269	40	1	2.2	2.2	NUM
ajst-32269	40	2	biomarkers	biomarker	NOUN
ajst-32269	40	3	of	of	ADP
ajst-32269	40	4	effect	effect	NOUN
ajst-32269	40	5	effect	effect	NOUN
ajst-32269	40	6	biomarkers	biomarker	NOUN
ajst-32269	40	7	refer	refer	VERB
ajst-32269	40	8	to	to	ADP
ajst-32269	40	9	identifiable	identifiable	ADJ
ajst-32269	40	10	biochemical	biochemical	ADJ
ajst-32269	40	11	,	,	PUNCT
ajst-32269	40	12	physiological	physiological	ADJ
ajst-32269	40	13	,	,	PUNCT
ajst-32269	40	14	behavioral	behavioral	ADJ
ajst-32269	40	15	,	,	PUNCT
ajst-32269	40	16	or	or	CCONJ
ajst-32269	40	17	other	other	ADJ
ajst-32269	40	18	internal	internal	ADJ
ajst-32269	40	19	changes	change	NOUN
ajst-32269	40	20	that	that	PRON
ajst-32269	40	21	can	can	AUX
ajst-32269	40	22	reflect	reflect	VERB
ajst-32269	40	23	the	the	DET
ajst-32269	40	24	early	early	ADJ
ajst-32269	40	25	biological	biological	ADJ
ajst-32269	40	26	effects	effect	NOUN
ajst-32269	40	27	of	of	ADP
ajst-32269	40	28	a	a	DET
ajst-32269	40	29	chemical	chemical	NOUN
ajst-32269	40	30	or	or	CCONJ
ajst-32269	40	31	its	its	PRON
ajst-32269	40	32	metabolites	metabolite	NOUN
ajst-32269	40	33	,	,	PUNCT
ajst-32269	40	34	changes	change	NOUN
ajst-32269	40	35	in	in	ADP
ajst-32269	40	36	body	body	NOUN
ajst-32269	40	37	structure	structure	NOUN
ajst-32269	40	38	or	or	CCONJ
ajst-32269	40	39	function	function	NOUN
ajst-32269	40	40	,	,	PUNCT
ajst-32269	40	41	or	or	CCONJ
ajst-32269	40	42	disease	disease	NOUN
ajst-32269	40	43	[	[	X
ajst-32269	40	44	7	7	NUM
ajst-32269	40	45	]	]	PUNCT
ajst-32269	40	46	.	.	PUNCT
ajst-32269	41	1	these	these	DET
ajst-32269	41	2	biomarkers	biomarker	NOUN
ajst-32269	41	3	reside	reside	VERB
ajst-32269	41	4	in	in	ADP
ajst-32269	41	5	the	the	DET
ajst-32269	41	6	intermediate	intermediate	ADJ
ajst-32269	41	7	process	process	NOUN
ajst-32269	41	8	of	of	ADP
ajst-32269	41	9	the	the	DET
ajst-32269	41	10	exposure	exposure	NOUN
ajst-32269	41	11	-	-	PUNCT
ajst-32269	41	12	disease	disease	NOUN
ajst-32269	41	13	continuum	continuum	NOUN
ajst-32269	41	14	,	,	PUNCT
ajst-32269	41	15	being	be	AUX
ajst-32269	41	16	neither	neither	CCONJ
ajst-32269	41	17	exposure	exposure	NOUN
ajst-32269	41	18	indicators	indicator	NOUN
ajst-32269	41	19	nor	nor	CCONJ
ajst-32269	41	20	clinical	clinical	ADJ
ajst-32269	41	21	disease	disease	NOUN
ajst-32269	41	22	endpoints	endpoint	NOUN
ajst-32269	41	23	,	,	PUNCT
ajst-32269	41	24	but	but	CCONJ
ajst-32269	41	25	rather	rather	ADV
ajst-32269	41	26	the	the	DET
ajst-32269	41	27	biological	biological	ADJ
ajst-32269	41	28	bridge	bridge	NOUN
ajst-32269	41	29	connecting	connect	VERB
ajst-32269	41	30	the	the	DET
ajst-32269	41	31	two	two	NUM
ajst-32269	41	32	.	.	PUNCT
ajst-32269	42	1	the	the	DET
ajst-32269	42	2	core	core	NOUN
ajst-32269	42	3	value	value	NOUN
ajst-32269	42	4	of	of	ADP
ajst-32269	42	5	effective	effective	ADJ
ajst-32269	42	6	biomarkers	biomarker	NOUN
ajst-32269	42	7	lies	lie	VERB
ajst-32269	42	8	in	in	ADP
ajst-32269	42	9	their	their	PRON
ajst-32269	42	10	ability	ability	NOUN
ajst-32269	42	11	to	to	PART
ajst-32269	42	12	provide	provide	VERB
ajst-32269	42	13	early	early	ADJ
ajst-32269	42	14	warning	warning	NOUN
ajst-32269	42	15	signals	signal	NOUN
ajst-32269	42	16	of	of	ADP
ajst-32269	42	17	exposure	exposure	NOUN
ajst-32269	42	18	-	-	PUNCT
ajst-32269	42	19	related	relate	VERB
ajst-32269	42	20	health	health	NOUN
ajst-32269	42	21	damage	damage	NOUN
ajst-32269	42	22	,	,	PUNCT
ajst-32269	42	23	offering	offer	VERB
ajst-32269	42	24	a	a	DET
ajst-32269	42	25	time	time	NOUN
ajst-32269	42	26	window	window	NOUN
ajst-32269	42	27	for	for	ADP
ajst-32269	42	28	preventive	preventive	ADJ
ajst-32269	42	29	intervention	intervention	NOUN
ajst-32269	42	30	.	.	PUNCT
ajst-32269	43	1	due	due	ADP
ajst-32269	43	2	to	to	ADP
ajst-32269	43	3	their	their	PRON
ajst-32269	43	4	high	high	ADJ
ajst-32269	43	5	sensitivity	sensitivity	NOUN
ajst-32269	43	6	,	,	PUNCT
ajst-32269	43	7	molecular	molecular	ADJ
ajst-32269	43	8	effect	effect	NOUN
ajst-32269	43	9	biomarkers	biomarker	NOUN
ajst-32269	43	10	can	can	AUX
ajst-32269	43	11	provide	provide	VERB
ajst-32269	43	12	more	more	ADJ
ajst-32269	43	13	objective	objective	ADJ
ajst-32269	43	14	and	and	CCONJ
ajst-32269	43	15	reliable	reliable	ADJ
ajst-32269	43	16	evaluation	evaluation	NOUN
ajst-32269	43	17	indicators	indicator	NOUN
ajst-32269	43	18	,	,	PUNCT
ajst-32269	43	19	particularly	particularly	ADV
ajst-32269	43	20	suitable	suitable	ADJ
ajst-32269	43	21	for	for	ADP
ajst-32269	43	22	situations	situation	NOUN
ajst-32269	43	23	involving	involve	VERB
ajst-32269	43	24	low60	low60	PROPN
ajst-32269	43	25	dose	dose	VERB
ajst-32269	43	26	exposure	exposure	NOUN
ajst-32269	43	27	to	to	ADP
ajst-32269	43	28	most	most	ADJ
ajst-32269	43	29	environmental	environmental	ADJ
ajst-32269	43	30	chemicals	chemical	NOUN
ajst-32269	43	31	in	in	ADP
ajst-32269	43	32	humans	human	NOUN
ajst-32269	43	33	[	[	X
ajst-32269	43	34	8	8	NUM
ajst-32269	43	35	]	]	PUNCT
ajst-32269	43	36	.	.	PUNCT
ajst-32269	44	1	biomarkers	biomarker	NOUN
ajst-32269	44	2	of	of	ADP
ajst-32269	44	3	early	early	ADJ
ajst-32269	44	4	biological	biological	ADJ
ajst-32269	44	5	effects	effect	NOUN
ajst-32269	44	6	can	can	AUX
ajst-32269	44	7	detect	detect	VERB
ajst-32269	44	8	reversible	reversible	ADJ
ajst-32269	44	9	and	and	CCONJ
ajst-32269	44	10	subclinical	subclinical	ADJ
ajst-32269	44	11	lesions	lesion	NOUN
ajst-32269	44	12	early	early	ADV
ajst-32269	44	13	,	,	PUNCT
ajst-32269	44	14	ensuring	ensure	VERB
ajst-32269	44	15	effective	effective	ADJ
ajst-32269	44	16	rehabilitation	rehabilitation	NOUN
ajst-32269	44	17	[	[	X
ajst-32269	44	18	9	9	NUM
ajst-32269	44	19	]	]	PUNCT
ajst-32269	44	20	.	.	PUNCT
ajst-32269	45	1	from	from	ADP
ajst-32269	45	2	a	a	DET
ajst-32269	45	3	biological	biological	ADJ
ajst-32269	45	4	mechanism	mechanism	NOUN
ajst-32269	45	5	perspective	perspective	NOUN
ajst-32269	45	6	,	,	PUNCT
ajst-32269	45	7	effect	effect	NOUN
ajst-32269	45	8	biomarkers	biomarker	NOUN
ajst-32269	45	9	reflect	reflect	VERB
ajst-32269	45	10	biological	biological	ADJ
ajst-32269	45	11	systems	system	NOUN
ajst-32269	45	12	'	'	PART
ajst-32269	45	13	initial	initial	ADJ
ajst-32269	45	14	disturbance	disturbance	NOUN
ajst-32269	45	15	and	and	CCONJ
ajst-32269	45	16	adaptive	adaptive	ADJ
ajst-32269	45	17	response	response	NOUN
ajst-32269	45	18	to	to	ADP
ajst-32269	45	19	environmental	environmental	ADJ
ajst-32269	45	20	exposure	exposure	NOUN
ajst-32269	45	21	.	.	PUNCT
ajst-32269	46	1	for	for	ADP
ajst-32269	46	2	example	example	NOUN
ajst-32269	46	3	,	,	PUNCT
ajst-32269	46	4	when	when	SCONJ
ajst-32269	46	5	the	the	DET
ajst-32269	46	6	body	body	NOUN
ajst-32269	46	7	encounters	encounter	VERB
ajst-32269	46	8	oxidative	oxidative	ADJ
ajst-32269	46	9	stress	stress	NOUN
ajst-32269	46	10	,	,	PUNCT
ajst-32269	46	11	it	it	PRON
ajst-32269	46	12	activates	activate	VERB
ajst-32269	46	13	antioxidant	antioxidant	ADJ
ajst-32269	46	14	defense	defense	NOUN
ajst-32269	46	15	mechanisms	mechanism	NOUN
ajst-32269	46	16	while	while	SCONJ
ajst-32269	46	17	producing	produce	VERB
ajst-32269	46	18	oxidative	oxidative	ADJ
ajst-32269	46	19	damage	damage	NOUN
ajst-32269	46	20	products	product	NOUN
ajst-32269	46	21	.	.	PUNCT
ajst-32269	47	1	these	these	DET
ajst-32269	47	2	dynamic	dynamic	ADJ
ajst-32269	47	3	changes	change	NOUN
ajst-32269	47	4	can	can	AUX
ajst-32269	47	5	be	be	AUX
ajst-32269	47	6	captured	capture	VERB
ajst-32269	47	7	by	by	ADP
ajst-32269	47	8	measuring	measure	VERB
ajst-32269	47	9	specific	specific	ADJ
ajst-32269	47	10	biomarkers	biomarker	NOUN
ajst-32269	47	11	.	.	PUNCT
ajst-32269	48	1	in	in	ADP
ajst-32269	48	2	recent	recent	ADJ
ajst-32269	48	3	years	year	NOUN
ajst-32269	48	4	,	,	PUNCT
ajst-32269	48	5	with	with	ADP
ajst-32269	48	6	the	the	DET
ajst-32269	48	7	development	development	NOUN
ajst-32269	48	8	of	of	ADP
ajst-32269	48	9	omics	omics	PROPN
ajst-32269	48	10	technologies	technology	NOUN
ajst-32269	48	11	,	,	PUNCT
ajst-32269	48	12	research	research	NOUN
ajst-32269	48	13	on	on	ADP
ajst-32269	48	14	effect	effect	NOUN
ajst-32269	48	15	biomarkers	biomarker	NOUN
ajst-32269	48	16	has	have	AUX
ajst-32269	48	17	evolved	evolve	VERB
ajst-32269	48	18	from	from	ADP
ajst-32269	48	19	single	single	ADJ
ajst-32269	48	20	indicators	indicator	NOUN
ajst-32269	48	21	to	to	PART
ajst-32269	48	22	integrated	integrate	VERB
ajst-32269	48	23	multi	multi	ADJ
ajst-32269	48	24	-	-	ADJ
ajst-32269	48	25	omics	omics	ADJ
ajst-32269	48	26	analysis	analysis	NOUN
ajst-32269	48	27	,	,	PUNCT
ajst-32269	48	28	including	include	VERB
ajst-32269	48	29	epigenomics	epigenomic	NOUN
ajst-32269	48	30	,	,	PUNCT
ajst-32269	48	31	transcriptomics	transcriptomic	NOUN
ajst-32269	48	32	,	,	PUNCT
ajst-32269	48	33	proteomics	proteomic	NOUN
ajst-32269	48	34	,	,	PUNCT
ajst-32269	48	35	and	and	CCONJ
ajst-32269	48	36	metabolomics	metabolomic	NOUN
ajst-32269	48	37	.	.	PUNCT
ajst-32269	49	1	regarding	regard	VERB
ajst-32269	49	2	technical	technical	ADJ
ajst-32269	49	3	methods	method	NOUN
ajst-32269	49	4	,	,	PUNCT
ajst-32269	49	5	the	the	DET
ajst-32269	49	6	detection	detection	NOUN
ajst-32269	49	7	of	of	ADP
ajst-32269	49	8	effect	effect	NOUN
ajst-32269	49	9	biomarkers	biomarker	NOUN
ajst-32269	49	10	encompasses	encompass	VERB
ajst-32269	49	11	various	various	ADJ
ajst-32269	49	12	platforms	platform	NOUN
ajst-32269	49	13	from	from	ADP
ajst-32269	49	14	traditional	traditional	ADJ
ajst-32269	49	15	enzymatic	enzymatic	ADJ
ajst-32269	49	16	analysis	analysis	NOUN
ajst-32269	49	17	and	and	CCONJ
ajst-32269	49	18	immunoassays	immunoassay	NOUN
ajst-32269	49	19	to	to	ADP
ajst-32269	49	20	modern	modern	ADJ
ajst-32269	49	21	high	high	ADJ
ajst-32269	49	22	-	-	PUNCT
ajst-32269	49	23	throughput	throughput	NOUN
ajst-32269	49	24	sequencing	sequencing	NOUN
ajst-32269	49	25	and	and	CCONJ
ajst-32269	49	26	mass	mass	ADJ
ajst-32269	49	27	spectrometry	spectrometry	NOUN
ajst-32269	49	28	imaging	imaging	NOUN
ajst-32269	49	29	.	.	PUNCT
ajst-32269	50	1	particularly	particularly	ADV
ajst-32269	50	2	,	,	PUNCT
ajst-32269	50	3	advances	advance	NOUN
ajst-32269	50	4	in	in	ADP
ajst-32269	50	5	mass	mass	ADJ
ajst-32269	50	6	spectrometry	spectrometry	NOUN
ajst-32269	50	7	have	have	AUX
ajst-32269	50	8	enabled	enable	VERB
ajst-32269	50	9	the	the	DET
ajst-32269	50	10	simultaneous	simultaneous	ADJ
ajst-32269	50	11	detection	detection	NOUN
ajst-32269	50	12	of	of	ADP
ajst-32269	50	13	hundreds	hundred	NOUN
ajst-32269	50	14	of	of	ADP
ajst-32269	50	15	metabolic	metabolic	NOUN
ajst-32269	50	16	products	product	NOUN
ajst-32269	50	17	and	and	CCONJ
ajst-32269	50	18	protein	protein	NOUN
ajst-32269	50	19	modifications	modification	NOUN
ajst-32269	50	20	,	,	PUNCT
ajst-32269	50	21	providing	provide	VERB
ajst-32269	50	22	a	a	DET
ajst-32269	50	23	powerful	powerful	ADJ
ajst-32269	50	24	tool	tool	NOUN
ajst-32269	50	25	for	for	ADP
ajst-32269	50	26	systematically	systematically	ADV
ajst-32269	50	27	understanding	understand	VERB
ajst-32269	50	28	the	the	DET
ajst-32269	50	29	biological	biological	ADJ
ajst-32269	50	30	effects	effect	NOUN
ajst-32269	50	31	of	of	ADP
ajst-32269	50	32	environmental	environmental	ADJ
ajst-32269	50	33	exposure	exposure	NOUN
ajst-32269	50	34	.	.	PUNCT
ajst-32269	51	1	furthermore	furthermore	ADV
ajst-32269	51	2	,	,	PUNCT
ajst-32269	51	3	the	the	DET
ajst-32269	51	4	emergence	emergence	NOUN
ajst-32269	51	5	of	of	ADP
ajst-32269	51	6	single	single	ADJ
ajst-32269	51	7	-	-	PUNCT
ajst-32269	51	8	cell	cell	NOUN
ajst-32269	51	9	sequencing	sequence	VERB
ajst-32269	51	10	technology	technology	NOUN
ajst-32269	51	11	allows	allow	VERB
ajst-32269	51	12	researchers	researcher	NOUN
ajst-32269	51	13	to	to	PART
ajst-32269	51	14	study	study	VERB
ajst-32269	51	15	the	the	DET
ajst-32269	51	16	effects	effect	NOUN
ajst-32269	51	17	of	of	ADP
ajst-32269	51	18	environmental	environmental	ADJ
ajst-32269	51	19	exposure	exposure	NOUN
ajst-32269	51	20	at	at	ADP
ajst-32269	51	21	the	the	DET
ajst-32269	51	22	single	single	ADJ
ajst-32269	51	23	-	-	PUNCT
ajst-32269	51	24	cell	cell	NOUN
ajst-32269	51	25	level	level	NOUN
ajst-32269	51	26	,	,	PUNCT
ajst-32269	51	27	offering	offer	VERB
ajst-32269	51	28	new	new	ADJ
ajst-32269	51	29	perspectives	perspective	NOUN
ajst-32269	51	30	for	for	ADP
ajst-32269	51	31	understanding	understand	VERB
ajst-32269	51	32	cellular	cellular	ADJ
ajst-32269	51	33	heterogeneity	heterogeneity	NOUN
ajst-32269	51	34	and	and	CCONJ
ajst-32269	51	35	microenvironment	microenvironment	ADJ
ajst-32269	51	36	effects	effect	NOUN
ajst-32269	51	37	.	.	PUNCT
ajst-32269	52	1	2.3	2.3	NUM
ajst-32269	52	2	biomarkers	biomarker	NOUN
ajst-32269	52	3	of	of	ADP
ajst-32269	52	4	susceptibility	susceptibility	NOUN
ajst-32269	52	5	biomarkers	biomarker	NOUN
ajst-32269	52	6	of	of	ADP
ajst-32269	52	7	susceptibility	susceptibility	NOUN
ajst-32269	52	8	refer	refer	VERB
ajst-32269	52	9	to	to	ADP
ajst-32269	52	10	biological	biological	ADJ
ajst-32269	52	11	indicators	indicator	NOUN
ajst-32269	52	12	that	that	PRON
ajst-32269	52	13	can	can	AUX
ajst-32269	52	14	reflect	reflect	VERB
ajst-32269	52	15	individual	individual	ADJ
ajst-32269	52	16	differences	difference	NOUN
ajst-32269	52	17	in	in	ADP
ajst-32269	52	18	response	response	NOUN
ajst-32269	52	19	to	to	ADP
ajst-32269	52	20	environmental	environmental	ADJ
ajst-32269	52	21	exposure	exposure	NOUN
ajst-32269	52	22	,	,	PUNCT
ajst-32269	52	23	including	include	VERB
ajst-32269	52	24	genetic	genetic	ADJ
ajst-32269	52	25	factors	factor	NOUN
ajst-32269	52	26	,	,	PUNCT
ajst-32269	52	27	epigenetic	epigenetic	ADJ
ajst-32269	52	28	modifications	modification	NOUN
ajst-32269	52	29	,	,	PUNCT
ajst-32269	52	30	physiological	physiological	ADJ
ajst-32269	52	31	status	status	NOUN
ajst-32269	52	32	,	,	PUNCT
ajst-32269	52	33	and	and	CCONJ
ajst-32269	52	34	other	other	ADJ
ajst-32269	52	35	aspects	aspect	NOUN
ajst-32269	52	36	.	.	PUNCT
ajst-32269	53	1	these	these	DET
ajst-32269	53	2	biomarkers	biomarker	NOUN
ajst-32269	53	3	explain	explain	VERB
ajst-32269	53	4	why	why	SCONJ
ajst-32269	53	5	different	different	ADJ
ajst-32269	53	6	individuals	individual	NOUN
ajst-32269	53	7	exhibit	exhibit	VERB
ajst-32269	53	8	varying	vary	VERB
ajst-32269	53	9	health	health	NOUN
ajst-32269	53	10	effects	effect	NOUN
ajst-32269	53	11	under	under	ADP
ajst-32269	53	12	the	the	DET
ajst-32269	53	13	same	same	ADJ
ajst-32269	53	14	environmental	environmental	ADJ
ajst-32269	53	15	exposure	exposure	NOUN
ajst-32269	53	16	conditions	condition	NOUN
ajst-32269	53	17	,	,	PUNCT
ajst-32269	53	18	providing	provide	VERB
ajst-32269	53	19	a	a	DET
ajst-32269	53	20	molecular	molecular	ADJ
ajst-32269	53	21	basis	basis	NOUN
ajst-32269	53	22	for	for	ADP
ajst-32269	53	23	understanding	understand	VERB
ajst-32269	53	24	individual	individual	ADJ
ajst-32269	53	25	differences	difference	NOUN
ajst-32269	53	26	in	in	ADP
ajst-32269	53	27	environmental	environmental	ADJ
ajst-32269	53	28	health	health	NOUN
ajst-32269	53	29	issues	issue	NOUN
ajst-32269	53	30	.	.	PUNCT
ajst-32269	54	1	genetic	genetic	ADJ
ajst-32269	54	2	susceptibility	susceptibility	NOUN
ajst-32269	54	3	biomarkers	biomarker	NOUN
ajst-32269	54	4	primarily	primarily	ADV
ajst-32269	54	5	involve	involve	VERB
ajst-32269	54	6	the	the	DET
ajst-32269	54	7	study	study	NOUN
ajst-32269	54	8	of	of	ADP
ajst-32269	54	9	gene	gene	NOUN
ajst-32269	54	10	polymorphisms	polymorphism	NOUN
ajst-32269	54	11	,	,	PUNCT
ajst-32269	54	12	especially	especially	ADV
ajst-32269	54	13	those	those	PRON
ajst-32269	54	14	encoding	encode	VERB
ajst-32269	54	15	metabolic	metabolic	NOUN
ajst-32269	54	16	enzymes	enzyme	NOUN
ajst-32269	54	17	,	,	PUNCT
ajst-32269	54	18	dna	dna	PROPN
ajst-32269	54	19	repair	repair	NOUN
ajst-32269	54	20	enzymes	enzyme	NOUN
ajst-32269	54	21	,	,	PUNCT
ajst-32269	54	22	cell	cell	NOUN
ajst-32269	54	23	receptors	receptor	NOUN
ajst-32269	54	24	,	,	PUNCT
ajst-32269	54	25	and	and	CCONJ
ajst-32269	54	26	key	key	ADJ
ajst-32269	54	27	components	component	NOUN
ajst-32269	54	28	of	of	ADP
ajst-32269	54	29	signaling	signal	VERB
ajst-32269	54	30	pathways	pathway	NOUN
ajst-32269	54	31	.	.	PUNCT
ajst-32269	55	1	genome	genome	NOUN
ajst-32269	55	2	-	-	PUNCT
ajst-32269	55	3	wide	wide	ADJ
ajst-32269	55	4	association	association	NOUN
ajst-32269	55	5	studies	study	NOUN
ajst-32269	55	6	(	(	PUNCT
ajst-32269	55	7	gwas	gwas	PROPN
ajst-32269	55	8	)	)	PUNCT
ajst-32269	55	9	have	have	AUX
ajst-32269	55	10	identified	identify	VERB
ajst-32269	55	11	hundreds	hundred	NOUN
ajst-32269	55	12	of	of	ADP
ajst-32269	55	13	genetic	genetic	ADJ
ajst-32269	55	14	variants	variant	NOUN
ajst-32269	55	15	associated	associate	VERB
ajst-32269	55	16	with	with	ADP
ajst-32269	55	17	the	the	DET
ajst-32269	55	18	risk	risk	NOUN
ajst-32269	55	19	of	of	ADP
ajst-32269	55	20	environment	environment	NOUN
ajst-32269	55	21	-	-	PUNCT
ajst-32269	55	22	related	relate	VERB
ajst-32269	55	23	diseases	disease	NOUN
ajst-32269	55	24	,	,	PUNCT
ajst-32269	55	25	greatly	greatly	ADV
ajst-32269	55	26	enhancing	enhance	VERB
ajst-32269	55	27	our	our	PRON
ajst-32269	55	28	understanding	understanding	NOUN
ajst-32269	55	29	of	of	ADP
ajst-32269	55	30	complex	complex	ADJ
ajst-32269	55	31	phenotypes	phenotype	NOUN
ajst-32269	55	32	and	and	CCONJ
ajst-32269	55	33	achieving	achieve	VERB
ajst-32269	55	34	fruitful	fruitful	ADJ
ajst-32269	55	35	results	result	NOUN
ajst-32269	55	36	in	in	ADP
ajst-32269	55	37	studying	study	VERB
ajst-32269	55	38	human	human	ADJ
ajst-32269	55	39	complex	complex	ADJ
ajst-32269	55	40	diseases	disease	NOUN
ajst-32269	55	41	[	[	X
ajst-32269	55	42	10	10	NUM
ajst-32269	55	43	]	]	PUNCT
ajst-32269	55	44	.	.	PUNCT
ajst-32269	56	1	however	however	ADV
ajst-32269	56	2	,	,	PUNCT
ajst-32269	56	3	the	the	DET
ajst-32269	56	4	current	current	ADJ
ajst-32269	56	5	research	research	NOUN
ajst-32269	56	6	trend	trend	NOUN
ajst-32269	56	7	is	be	AUX
ajst-32269	56	8	moving	move	VERB
ajst-32269	56	9	from	from	ADP
ajst-32269	56	10	single	single	ADJ
ajst-32269	56	11	genetic	genetic	ADJ
ajst-32269	56	12	variants	variant	NOUN
ajst-32269	56	13	to	to	ADP
ajst-32269	56	14	polygenic	polygenic	ADJ
ajst-32269	56	15	risk	risk	NOUN
ajst-32269	56	16	scores	score	NOUN
ajst-32269	56	17	,	,	PUNCT
ajst-32269	56	18	integrating	integrate	VERB
ajst-32269	56	19	information	information	NOUN
ajst-32269	56	20	from	from	ADP
ajst-32269	56	21	multiple	multiple	ADJ
ajst-32269	56	22	genetic	genetic	ADJ
ajst-32269	56	23	variants	variant	NOUN
ajst-32269	56	24	to	to	PART
ajst-32269	56	25	predict	predict	VERB
ajst-32269	56	26	an	an	DET
ajst-32269	56	27	individual	individual	NOUN
ajst-32269	56	28	's	's	PART
ajst-32269	56	29	disease	disease	NOUN
ajst-32269	56	30	susceptibility	susceptibility	NOUN
ajst-32269	56	31	better	well	ADV
ajst-32269	56	32	.	.	PUNCT
ajst-32269	57	1	epigenetic	epigenetic	ADJ
ajst-32269	57	2	modifications	modification	NOUN
ajst-32269	57	3	,	,	PUNCT
ajst-32269	57	4	another	another	DET
ajst-32269	57	5	important	important	ADJ
ajst-32269	57	6	category	category	NOUN
ajst-32269	57	7	of	of	ADP
ajst-32269	57	8	susceptibility	susceptibility	NOUN
ajst-32269	57	9	biomarkers	biomarker	NOUN
ajst-32269	57	10	,	,	PUNCT
ajst-32269	57	11	provide	provide	VERB
ajst-32269	57	12	a	a	DET
ajst-32269	57	13	molecular	molecular	ADJ
ajst-32269	57	14	mechanism	mechanism	NOUN
ajst-32269	57	15	linking	link	VERB
ajst-32269	57	16	environmental	environmental	ADJ
ajst-32269	57	17	exposure	exposure	NOUN
ajst-32269	57	18	to	to	ADP
ajst-32269	57	19	gene	gene	NOUN
ajst-32269	57	20	expression	expression	NOUN
ajst-32269	57	21	regulation	regulation	NOUN
ajst-32269	57	22	.	.	PUNCT
ajst-32269	58	1	environmental	environmental	ADJ
ajst-32269	58	2	factors	factor	NOUN
ajst-32269	58	3	influence	influence	VERB
ajst-32269	58	4	epigenetic	epigenetic	ADJ
ajst-32269	58	5	marks	mark	NOUN
ajst-32269	58	6	such	such	ADJ
ajst-32269	58	7	as	as	ADP
ajst-32269	58	8	dna	dna	PROPN
ajst-32269	58	9	methylation	methylation	NOUN
ajst-32269	58	10	,	,	PUNCT
ajst-32269	58	11	histone	histone	NOUN
ajst-32269	58	12	modification	modification	NOUN
ajst-32269	58	13	,	,	PUNCT
ajst-32269	58	14	and	and	CCONJ
ajst-32269	58	15	non	non	ADJ
ajst-32269	58	16	-	-	ADJ
ajst-32269	58	17	coding	code	VERB
ajst-32269	58	18	rna	rna	NOUN
ajst-32269	58	19	,	,	PUNCT
ajst-32269	58	20	which	which	PRON
ajst-32269	58	21	may	may	AUX
ajst-32269	58	22	affect	affect	VERB
ajst-32269	58	23	an	an	DET
ajst-32269	58	24	individual	individual	NOUN
ajst-32269	58	25	's	's	PART
ajst-32269	58	26	sensitivity	sensitivity	NOUN
ajst-32269	58	27	to	to	ADP
ajst-32269	58	28	environmental	environmental	ADJ
ajst-32269	58	29	exposure	exposure	NOUN
ajst-32269	58	30	.	.	PUNCT
ajst-32269	59	1	this	this	DET
ajst-32269	59	2	bidirectional	bidirectional	ADJ
ajst-32269	59	3	regulatory	regulatory	ADJ
ajst-32269	59	4	mechanism	mechanism	NOUN
ajst-32269	59	5	gives	give	VERB
ajst-32269	59	6	epigenetic	epigenetic	ADJ
ajst-32269	59	7	biomarkers	biomarker	NOUN
ajst-32269	59	8	exceptional	exceptional	ADJ
ajst-32269	59	9	value	value	NOUN
ajst-32269	59	10	in	in	ADP
ajst-32269	59	11	environmental	environmental	ADJ
ajst-32269	59	12	health	health	NOUN
ajst-32269	59	13	research	research	NOUN
ajst-32269	59	14	.	.	PUNCT
ajst-32269	60	1	advances	advance	NOUN
ajst-32269	60	2	in	in	ADP
ajst-32269	60	3	detection	detection	NOUN
ajst-32269	60	4	technology	technology	NOUN
ajst-32269	60	5	have	have	AUX
ajst-32269	60	6	significantly	significantly	ADV
ajst-32269	60	7	propelled	propel	VERB
ajst-32269	60	8	research	research	NOUN
ajst-32269	60	9	on	on	ADP
ajst-32269	60	10	susceptibility	susceptibility	NOUN
ajst-32269	60	11	biomarkers	biomarker	NOUN
ajst-32269	60	12	.	.	PUNCT
ajst-32269	61	1	from	from	ADP
ajst-32269	61	2	early	early	ADJ
ajst-32269	61	3	pcr	pcr	NOUN
ajst-32269	61	4	-	-	PUNCT
ajst-32269	61	5	based	base	VERB
ajst-32269	61	6	methods	method	NOUN
ajst-32269	61	7	to	to	PART
ajst-32269	61	8	current	current	VERB
ajst-32269	61	9	whole	whole	ADJ
ajst-32269	61	10	-	-	PUNCT
ajst-32269	61	11	genome	genome	NOUN
ajst-32269	61	12	sequencing	sequencing	NOUN
ajst-32269	61	13	,	,	PUNCT
ajst-32269	61	14	epigenome	epigenome	NOUN
ajst-32269	61	15	-	-	PUNCT
ajst-32269	61	16	wide	wide	ADJ
ajst-32269	61	17	association	association	NOUN
ajst-32269	61	18	studies	study	NOUN
ajst-32269	61	19	(	(	PUNCT
ajst-32269	61	20	ewas	ewas	PROPN
ajst-32269	61	21	)	)	PUNCT
ajst-32269	61	22	,	,	PUNCT
ajst-32269	61	23	and	and	CCONJ
ajst-32269	61	24	metagenomic	metagenomic	ADJ
ajst-32269	61	25	sequencing	sequencing	NOUN
ajst-32269	61	26	[	[	X
ajst-32269	61	27	11	11	NUM
ajst-32269	61	28	]	]	PUNCT
ajst-32269	61	29	,	,	PUNCT
ajst-32269	61	30	we	we	PRON
ajst-32269	61	31	can	can	AUX
ajst-32269	61	32	study	study	VERB
ajst-32269	61	33	the	the	DET
ajst-32269	61	34	molecular	molecular	ADJ
ajst-32269	61	35	basis	basis	NOUN
ajst-32269	61	36	of	of	ADP
ajst-32269	61	37	individual	individual	ADJ
ajst-32269	61	38	susceptibility	susceptibility	NOUN
ajst-32269	61	39	with	with	ADP
ajst-32269	61	40	higher	high	ADJ
ajst-32269	61	41	resolution	resolution	NOUN
ajst-32269	61	42	and	and	CCONJ
ajst-32269	61	43	a	a	DET
ajst-32269	61	44	more	more	ADV
ajst-32269	61	45	comprehensive	comprehensive	ADJ
ajst-32269	61	46	perspective	perspective	NOUN
ajst-32269	61	47	.	.	PUNCT
ajst-32269	62	1	the	the	DET
ajst-32269	62	2	development	development	NOUN
ajst-32269	62	3	of	of	ADP
ajst-32269	62	4	single	single	ADJ
ajst-32269	62	5	-	-	PUNCT
ajst-32269	62	6	cell	cell	NOUN
ajst-32269	62	7	multi	multi	ADJ
ajst-32269	62	8	-	-	ADJ
ajst-32269	62	9	omics	omics	ADJ
ajst-32269	62	10	technologies	technology	NOUN
ajst-32269	62	11	enables	enable	VERB
ajst-32269	62	12	researchers	researcher	NOUN
ajst-32269	62	13	to	to	PART
ajst-32269	62	14	simultaneously	simultaneously	ADV
ajst-32269	62	15	analyze	analyze	VERB
ajst-32269	62	16	genetic	genetic	ADJ
ajst-32269	62	17	variations	variation	NOUN
ajst-32269	62	18	,	,	PUNCT
ajst-32269	62	19	gene	gene	NOUN
ajst-32269	62	20	expression	expression	NOUN
ajst-32269	62	21	,	,	PUNCT
ajst-32269	62	22	and	and	CCONJ
ajst-32269	62	23	epigenetic	epigenetic	ADJ
ajst-32269	62	24	states	state	NOUN
ajst-32269	62	25	at	at	ADP
ajst-32269	62	26	the	the	DET
ajst-32269	62	27	single	single	ADJ
ajst-32269	62	28	-	-	PUNCT
ajst-32269	62	29	cell	cell	NOUN
ajst-32269	62	30	level	level	NOUN
ajst-32269	62	31	,	,	PUNCT
ajst-32269	62	32	providing	provide	VERB
ajst-32269	62	33	new	new	ADJ
ajst-32269	62	34	tools	tool	NOUN
ajst-32269	62	35	for	for	ADP
ajst-32269	62	36	understanding	understand	VERB
ajst-32269	62	37	the	the	DET
ajst-32269	62	38	cellular	cellular	ADJ
ajst-32269	62	39	heterogeneity	heterogeneity	NOUN
ajst-32269	62	40	of	of	ADP
ajst-32269	62	41	environmental	environmental	ADJ
ajst-32269	62	42	health	health	NOUN
ajst-32269	62	43	effects	effect	NOUN
ajst-32269	62	44	.	.	PUNCT
ajst-32269	63	1	3	3	X
ajst-32269	63	2	.	.	X
ajst-32269	63	3	application	application	NOUN
ajst-32269	63	4	of	of	ADP
ajst-32269	63	5	biomarkers	biomarker	NOUN
ajst-32269	63	6	in	in	ADP
ajst-32269	63	7	health	health	NOUN
ajst-32269	63	8	applying	apply	VERB
ajst-32269	63	9	molecular	molecular	ADJ
ajst-32269	63	10	biomarkers	biomarker	NOUN
ajst-32269	63	11	in	in	ADP
ajst-32269	63	12	environmental	environmental	ADJ
ajst-32269	63	13	health	health	NOUN
ajst-32269	63	14	research	research	NOUN
ajst-32269	63	15	has	have	AUX
ajst-32269	63	16	significantly	significantly	ADV
ajst-32269	63	17	expanded	expand	VERB
ajst-32269	63	18	our	our	PRON
ajst-32269	63	19	understanding	understanding	NOUN
ajst-32269	63	20	of	of	ADP
ajst-32269	63	21	the	the	DET
ajst-32269	63	22	relationship	relationship	NOUN
ajst-32269	63	23	between	between	ADP
ajst-32269	63	24	environmental	environmental	ADJ
ajst-32269	63	25	exposure	exposure	NOUN
ajst-32269	63	26	and	and	CCONJ
ajst-32269	63	27	health	health	NOUN
ajst-32269	63	28	effects	effect	NOUN
ajst-32269	63	29	.	.	PUNCT
ajst-32269	64	1	by	by	ADP
ajst-32269	64	2	detecting	detect	VERB
ajst-32269	64	3	specific	specific	ADJ
ajst-32269	64	4	biomarkers	biomarker	NOUN
ajst-32269	64	5	,	,	PUNCT
ajst-32269	64	6	we	we	PRON
ajst-32269	64	7	can	can	AUX
ajst-32269	64	8	assess	assess	VERB
ajst-32269	64	9	exposure	exposure	NOUN
ajst-32269	64	10	levels	level	NOUN
ajst-32269	64	11	more	more	ADV
ajst-32269	64	12	accurately	accurately	ADV
ajst-32269	64	13	and	and	CCONJ
ajst-32269	64	14	deeply	deeply	ADV
ajst-32269	64	15	reveal	reveal	VERB
ajst-32269	64	16	the	the	DET
ajst-32269	64	17	biological	biological	ADJ
ajst-32269	64	18	61	61	NUM
ajst-32269	64	19	mechanisms	mechanism	NOUN
ajst-32269	64	20	through	through	ADP
ajst-32269	64	21	which	which	PRON
ajst-32269	64	22	environmental	environmental	ADJ
ajst-32269	64	23	factors	factor	NOUN
ajst-32269	64	24	cause	cause	VERB
ajst-32269	64	25	health	health	NOUN
ajst-32269	64	26	damage	damage	NOUN
ajst-32269	64	27	.	.	PUNCT
ajst-32269	65	1	this	this	DET
ajst-32269	65	2	chapter	chapter	NOUN
ajst-32269	65	3	will	will	AUX
ajst-32269	65	4	focus	focus	VERB
ajst-32269	65	5	on	on	ADP
ajst-32269	65	6	applying	apply	VERB
ajst-32269	65	7	molecular	molecular	ADJ
ajst-32269	65	8	biomarkers	biomarker	NOUN
ajst-32269	65	9	in	in	ADP
ajst-32269	65	10	three	three	NUM
ajst-32269	65	11	typical	typical	ADJ
ajst-32269	65	12	environmental	environmental	ADJ
ajst-32269	65	13	exposure	exposure	NOUN
ajst-32269	65	14	areas	area	NOUN
ajst-32269	65	15	,	,	PUNCT
ajst-32269	65	16	combined	combine	VERB
ajst-32269	65	17	with	with	ADP
ajst-32269	65	18	specific	specific	ADJ
ajst-32269	65	19	case	case	NOUN
ajst-32269	65	20	analyses	analysis	NOUN
ajst-32269	65	21	.	.	PUNCT
ajst-32269	66	1	3.1	3.1	NUM
ajst-32269	66	2	ambient	ambient	ADJ
ajst-32269	66	3	fine	fine	ADJ
ajst-32269	66	4	particulate	particulate	NOUN
ajst-32269	66	5	matter	matter	NOUN
ajst-32269	66	6	(	(	PUNCT
ajst-32269	66	7	pm₂.₅	pm₂.₅	NOUN
ajst-32269	66	8	)	)	PUNCT
ajst-32269	66	9	exposure	exposure	NOUN
ajst-32269	66	10	and	and	CCONJ
ajst-32269	66	11	cardiopulmonary	cardiopulmonary	ADJ
ajst-32269	66	12	diseases	disease	NOUN
ajst-32269	66	13	ambient	ambient	NOUN
ajst-32269	66	14	pm₂.₅	pm₂.₅	NUM
ajst-32269	66	15	pollution	pollution	NOUN
ajst-32269	66	16	is	be	AUX
ajst-32269	66	17	one	one	NUM
ajst-32269	66	18	of	of	ADP
ajst-32269	66	19	the	the	DET
ajst-32269	66	20	most	most	ADV
ajst-32269	66	21	important	important	ADJ
ajst-32269	66	22	global	global	ADJ
ajst-32269	66	23	environmental	environmental	ADJ
ajst-32269	66	24	health	health	NOUN
ajst-32269	66	25	risk	risk	NOUN
ajst-32269	66	26	factors	factor	NOUN
ajst-32269	66	27	.	.	PUNCT
ajst-32269	67	1	biomarker	biomarker	NOUN
ajst-32269	67	2	-	-	PUNCT
ajst-32269	67	3	based	base	VERB
ajst-32269	67	4	studies	study	NOUN
ajst-32269	67	5	have	have	AUX
ajst-32269	67	6	provided	provide	VERB
ajst-32269	67	7	crucial	crucial	ADJ
ajst-32269	67	8	evidence	evidence	NOUN
ajst-32269	67	9	for	for	ADP
ajst-32269	67	10	understanding	understand	VERB
ajst-32269	67	11	the	the	DET
ajst-32269	67	12	health	health	NOUN
ajst-32269	67	13	hazard	hazard	NOUN
ajst-32269	67	14	mechanisms	mechanism	NOUN
ajst-32269	67	15	of	of	ADP
ajst-32269	67	16	pm₂.₅.	pm₂.₅.	PROPN
ajst-32269	67	17	cpg	cpg	NOUN
ajst-32269	67	18	is	be	AUX
ajst-32269	67	19	a	a	DET
ajst-32269	67	20	specific	specific	ADJ
ajst-32269	67	21	biomarker	biomarker	NOUN
ajst-32269	67	22	that	that	PRON
ajst-32269	67	23	can	can	AUX
ajst-32269	67	24	detect	detect	VERB
ajst-32269	67	25	pm₂.₅.	pm₂.₅.	PROPN
ajst-32269	67	26	dna	dna	PROPN
ajst-32269	67	27	methylation	methylation	NOUN
ajst-32269	67	28	is	be	AUX
ajst-32269	67	29	one	one	NUM
ajst-32269	67	30	of	of	ADP
ajst-32269	67	31	the	the	DET
ajst-32269	67	32	most	most	ADV
ajst-32269	67	33	common	common	ADJ
ajst-32269	67	34	epigenetic	epigenetic	ADJ
ajst-32269	67	35	modifications	modification	NOUN
ajst-32269	67	36	,	,	PUNCT
ajst-32269	67	37	mainly	mainly	ADV
ajst-32269	67	38	occurring	occur	VERB
ajst-32269	67	39	at	at	ADP
ajst-32269	67	40	the	the	DET
ajst-32269	67	41	cg	cg	NOUN
ajst-32269	67	42	dinucleotide	dinucleotide	NOUN
ajst-32269	67	43	sequence	sequence	NOUN
ajst-32269	67	44	of	of	ADP
ajst-32269	67	45	cpg	cpg	NOUN
ajst-32269	67	46	sites	site	NOUN
ajst-32269	67	47	.	.	PUNCT
ajst-32269	68	1	it	it	PRON
ajst-32269	68	2	is	be	AUX
ajst-32269	68	3	regarded	regard	VERB
ajst-32269	68	4	as	as	ADP
ajst-32269	68	5	an	an	DET
ajst-32269	68	6	early	early	ADJ
ajst-32269	68	7	molecular	molecular	ADJ
ajst-32269	68	8	biomarker	biomarker	NOUN
ajst-32269	68	9	for	for	ADP
ajst-32269	68	10	predicting	predict	VERB
ajst-32269	68	11	adverse	adverse	ADJ
ajst-32269	68	12	health	health	NOUN
ajst-32269	68	13	responses	response	NOUN
ajst-32269	68	14	related	relate	VERB
ajst-32269	68	15	to	to	ADP
ajst-32269	68	16	environmental	environmental	ADJ
ajst-32269	68	17	exposure	exposure	NOUN
ajst-32269	68	18	,	,	PUNCT
ajst-32269	68	19	reflecting	reflect	VERB
ajst-32269	68	20	the	the	DET
ajst-32269	68	21	changes	change	NOUN
ajst-32269	68	22	in	in	ADP
ajst-32269	68	23	cell	cell	NOUN
ajst-32269	68	24	states	state	NOUN
ajst-32269	68	25	caused	cause	VERB
ajst-32269	68	26	by	by	ADP
ajst-32269	68	27	environmental	environmental	ADJ
ajst-32269	68	28	exposure	exposure	NOUN
ajst-32269	68	29	and	and	CCONJ
ajst-32269	68	30	revealing	reveal	VERB
ajst-32269	68	31	the	the	DET
ajst-32269	68	32	interaction	interaction	NOUN
ajst-32269	68	33	between	between	ADP
ajst-32269	68	34	genes	gene	NOUN
ajst-32269	68	35	and	and	CCONJ
ajst-32269	68	36	the	the	DET
ajst-32269	68	37	environment	environment	NOUN
ajst-32269	68	38	more	more	ADV
ajst-32269	68	39	deeply	deeply	ADV
ajst-32269	68	40	.	.	PUNCT
ajst-32269	69	1	in	in	ADP
ajst-32269	69	2	the	the	DET
ajst-32269	69	3	methylation	methylation	NOUN
ajst-32269	69	4	modification	modification	NOUN
ajst-32269	69	5	of	of	ADP
ajst-32269	69	6	specific	specific	ADJ
ajst-32269	69	7	genes	gene	NOUN
ajst-32269	69	8	caused	cause	VERB
ajst-32269	69	9	by	by	ADP
ajst-32269	69	10	exposure	exposure	NOUN
ajst-32269	69	11	to	to	ADP
ajst-32269	69	12	exogenous	exogenous	ADJ
ajst-32269	69	13	chemicals	chemical	NOUN
ajst-32269	69	14	,	,	PUNCT
ajst-32269	69	15	certain	certain	ADJ
ajst-32269	69	16	specific	specific	ADJ
ajst-32269	69	17	cpg	cpg	NOUN
ajst-32269	69	18	sites	site	NOUN
ajst-32269	69	19	,	,	PUNCT
ajst-32269	69	20	especially	especially	ADV
ajst-32269	69	21	those	those	PRON
ajst-32269	69	22	located	locate	VERB
ajst-32269	69	23	in	in	ADP
ajst-32269	69	24	the	the	DET
ajst-32269	69	25	promoter	promoter	NOUN
ajst-32269	69	26	region	region	NOUN
ajst-32269	69	27	of	of	ADP
ajst-32269	69	28	genes	gene	NOUN
ajst-32269	69	29	,	,	PUNCT
ajst-32269	69	30	have	have	VERB
ajst-32269	69	31	specific	specific	ADJ
ajst-32269	69	32	regulatory	regulatory	ADJ
ajst-32269	69	33	roles	role	NOUN
ajst-32269	69	34	and	and	CCONJ
ajst-32269	69	35	play	play	VERB
ajst-32269	69	36	a	a	DET
ajst-32269	69	37	decisive	decisive	ADJ
ajst-32269	69	38	role	role	NOUN
ajst-32269	69	39	in	in	ADP
ajst-32269	69	40	the	the	DET
ajst-32269	69	41	activation	activation	NOUN
ajst-32269	69	42	and	and	CCONJ
ajst-32269	69	43	inhibition	inhibition	NOUN
ajst-32269	69	44	of	of	ADP
ajst-32269	69	45	gene	gene	NOUN
ajst-32269	69	46	transcription	transcription	NOUN
ajst-32269	69	47	.	.	PUNCT
ajst-32269	70	1	specific	specific	ADJ
ajst-32269	70	2	cpg	cpg	NOUN
ajst-32269	70	3	sites	site	NOUN
ajst-32269	70	4	are	be	AUX
ajst-32269	70	5	termed	term	VERB
ajst-32269	70	6	"	"	PUNCT
ajst-32269	70	7	cpg	cpg	NOUN
ajst-32269	70	8	hotspots	hotspot	NOUN
ajst-32269	70	9	.	.	PUNCT
ajst-32269	70	10	"	"	PUNCT
ajst-32269	71	1	identifying	identify	VERB
ajst-32269	71	2	the	the	DET
ajst-32269	71	3	specific	specific	ADJ
ajst-32269	71	4	regulation	regulation	NOUN
ajst-32269	71	5	of	of	ADP
ajst-32269	71	6	cpg	cpg	NOUN
ajst-32269	71	7	hotspots	hotspot	NOUN
ajst-32269	71	8	helps	help	VERB
ajst-32269	71	9	assess	assess	VERB
ajst-32269	71	10	the	the	DET
ajst-32269	71	11	biological	biological	ADJ
ajst-32269	71	12	effects	effect	NOUN
ajst-32269	71	13	of	of	ADP
ajst-32269	71	14	gene	gene	NOUN
ajst-32269	71	15	expression	expression	NOUN
ajst-32269	71	16	more	more	ADV
ajst-32269	71	17	accurately	accurately	ADV
ajst-32269	71	18	[	[	X
ajst-32269	71	19	12	12	NUM
ajst-32269	71	20	]	]	PUNCT
ajst-32269	71	21	.	.	PUNCT
ajst-32269	72	1	therefore	therefore	ADV
ajst-32269	72	2	,	,	PUNCT
ajst-32269	72	3	the	the	DET
ajst-32269	72	4	methylation	methylation	NOUN
ajst-32269	72	5	of	of	ADP
ajst-32269	72	6	specific	specific	ADJ
ajst-32269	72	7	cpg	cpg	NOUN
ajst-32269	72	8	sites	site	NOUN
ajst-32269	72	9	can	can	AUX
ajst-32269	72	10	be	be	AUX
ajst-32269	72	11	regarded	regard	VERB
ajst-32269	72	12	as	as	ADP
ajst-32269	72	13	a	a	DET
ajst-32269	72	14	potential	potential	ADJ
ajst-32269	72	15	effect	effect	NOUN
ajst-32269	72	16	biomarker	biomarker	NOUN
ajst-32269	72	17	for	for	ADP
ajst-32269	72	18	pm₂.₅	pm₂.₅	NUM
ajst-32269	72	19	exposure	exposure	NOUN
ajst-32269	72	20	.	.	PUNCT
ajst-32269	73	1	regarding	regard	VERB
ajst-32269	73	2	exposure	exposure	NOUN
ajst-32269	73	3	assessment	assessment	NOUN
ajst-32269	73	4	,	,	PUNCT
ajst-32269	73	5	urinary	urinary	ADJ
ajst-32269	73	6	1	1	NUM
ajst-32269	73	7	-	-	PUNCT
ajst-32269	73	8	hydroxypyrene	hydroxypyrene	NOUN
ajst-32269	73	9	(	(	PUNCT
ajst-32269	73	10	1	1	NUM
ajst-32269	73	11	-	-	PUNCT
ajst-32269	73	12	ohp	ohp	NOUN
ajst-32269	73	13	)	)	PUNCT
ajst-32269	73	14	,	,	PUNCT
ajst-32269	73	15	a	a	DET
ajst-32269	73	16	specific	specific	ADJ
ajst-32269	73	17	biomarker	biomarker	NOUN
ajst-32269	73	18	for	for	ADP
ajst-32269	73	19	polycyclic	polycyclic	ADJ
ajst-32269	73	20	aromatic	aromatic	ADJ
ajst-32269	73	21	hydrocarbon	hydrocarbon	NOUN
ajst-32269	73	22	(	(	PUNCT
ajst-32269	73	23	pah	pah	PROPN
ajst-32269	73	24	)	)	PUNCT
ajst-32269	73	25	exposure	exposure	NOUN
ajst-32269	73	26	,	,	PUNCT
ajst-32269	73	27	can	can	AUX
ajst-32269	73	28	effectively	effectively	ADV
ajst-32269	73	29	reflect	reflect	VERB
ajst-32269	73	30	the	the	DET
ajst-32269	73	31	internal	internal	ADJ
ajst-32269	73	32	exposure	exposure	NOUN
ajst-32269	73	33	level	level	NOUN
ajst-32269	73	34	of	of	ADP
ajst-32269	73	35	organic	organic	ADJ
ajst-32269	73	36	components	component	NOUN
ajst-32269	73	37	in	in	ADP
ajst-32269	73	38	pm₂.₅.	pm₂.₅.	PROPN
ajst-32269	73	39	studies	study	NOUN
ajst-32269	73	40	have	have	AUX
ajst-32269	73	41	shown	show	VERB
ajst-32269	73	42	that	that	SCONJ
ajst-32269	73	43	1	1	NUM
ajst-32269	73	44	-	-	PUNCT
ajst-32269	73	45	ohp	ohp	NOUN
ajst-32269	73	46	concentration	concentration	NOUN
ajst-32269	73	47	exhibits	exhibit	VERB
ajst-32269	73	48	a	a	DET
ajst-32269	73	49	good	good	ADJ
ajst-32269	73	50	doseresponse	doseresponse	NOUN
ajst-32269	73	51	relationship	relationship	NOUN
ajst-32269	73	52	with	with	ADP
ajst-32269	73	53	pm₂.₅	pm₂.₅	PUNCT
ajst-32269	73	54	exposure	exposure	NOUN
ajst-32269	73	55	concentration	concentration	NOUN
ajst-32269	73	56	and	and	CCONJ
ajst-32269	73	57	is	be	AUX
ajst-32269	73	58	significantly	significantly	ADV
ajst-32269	73	59	correlated	correlate	VERB
ajst-32269	73	60	with	with	ADP
ajst-32269	73	61	respiratory	respiratory	ADJ
ajst-32269	73	62	inflammation	inflammation	NOUN
ajst-32269	73	63	indicators	indicator	NOUN
ajst-32269	73	64	.	.	PUNCT
ajst-32269	74	1	at	at	ADP
ajst-32269	74	2	the	the	DET
ajst-32269	74	3	level	level	NOUN
ajst-32269	74	4	of	of	ADP
ajst-32269	74	5	effect	effect	NOUN
ajst-32269	74	6	biomarkers	biomarker	NOUN
ajst-32269	74	7	,	,	PUNCT
ajst-32269	74	8	multiple	multiple	ADJ
ajst-32269	74	9	studies	study	NOUN
ajst-32269	74	10	have	have	AUX
ajst-32269	74	11	found	find	VERB
ajst-32269	74	12	significant	significant	ADJ
ajst-32269	74	13	associations	association	NOUN
ajst-32269	74	14	between	between	ADP
ajst-32269	74	15	pm₂.₅-borne	pm₂.₅-borne	ADJ
ajst-32269	74	16	pahs	pah	NOUN
ajst-32269	74	17	and	and	CCONJ
ajst-32269	74	18	8	8	NUM
ajst-32269	74	19	-	-	PUNCT
ajst-32269	74	20	hydroxy-2'-deoxyguanosine	hydroxy-2'-deoxyguanosine	NOUN
ajst-32269	74	21	(	(	PUNCT
ajst-32269	74	22	8	8	NUM
ajst-32269	74	23	-	-	NUM
ajst-32269	74	24	ohdg	ohdg	NUM
ajst-32269	74	25	)	)	PUNCT
ajst-32269	74	26	,	,	PUNCT
ajst-32269	74	27	a	a	DET
ajst-32269	74	28	common	common	ADJ
ajst-32269	74	29	human	human	ADJ
ajst-32269	74	30	metabolite	metabolite	NOUN
ajst-32269	74	31	indicator	indicator	NOUN
ajst-32269	74	32	of	of	ADP
ajst-32269	74	33	dna	dna	PROPN
ajst-32269	74	34	oxidation	oxidation	NOUN
ajst-32269	75	1	[	[	X
ajst-32269	75	2	13	13	NUM
ajst-32269	75	3	]	]	SYM
ajst-32269	75	4	.	.	PUNCT
ajst-32269	75	5	3.2	3.2	NUM
ajst-32269	75	6	heavy	heavy	ADJ
ajst-32269	75	7	metal	metal	NOUN
ajst-32269	75	8	exposure	exposure	NOUN
ajst-32269	75	9	and	and	CCONJ
ajst-32269	75	10	health	health	NOUN
ajst-32269	75	11	risks	risk	NOUN
ajst-32269	75	12	heavy	heavy	ADJ
ajst-32269	75	13	metal	metal	NOUN
ajst-32269	75	14	exposure	exposure	NOUN
ajst-32269	75	15	is	be	AUX
ajst-32269	75	16	another	another	DET
ajst-32269	75	17	important	important	ADJ
ajst-32269	75	18	environmental	environmental	ADJ
ajst-32269	75	19	health	health	NOUN
ajst-32269	75	20	issue	issue	NOUN
ajst-32269	75	21	.	.	PUNCT
ajst-32269	76	1	blood	blood	NOUN
ajst-32269	76	2	lead	lead	NOUN
ajst-32269	76	3	and	and	CCONJ
ajst-32269	76	4	urinary	urinary	ADJ
ajst-32269	76	5	cadmium	cadmium	NOUN
ajst-32269	76	6	,	,	PUNCT
ajst-32269	76	7	as	as	ADP
ajst-32269	76	8	classic	classic	ADJ
ajst-32269	76	9	biomarkers	biomarker	NOUN
ajst-32269	76	10	of	of	ADP
ajst-32269	76	11	internal	internal	ADJ
ajst-32269	76	12	exposure	exposure	NOUN
ajst-32269	76	13	,	,	PUNCT
ajst-32269	76	14	play	play	VERB
ajst-32269	76	15	an	an	DET
ajst-32269	76	16	irreplaceable	irreplaceable	ADJ
ajst-32269	76	17	role	role	NOUN
ajst-32269	76	18	in	in	ADP
ajst-32269	76	19	the	the	DET
ajst-32269	76	20	health	health	NOUN
ajst-32269	76	21	risk	risk	NOUN
ajst-32269	76	22	assessment	assessment	NOUN
ajst-32269	76	23	of	of	ADP
ajst-32269	76	24	heavy	heavy	ADJ
ajst-32269	76	25	metals	metal	NOUN
ajst-32269	76	26	.	.	PUNCT
ajst-32269	77	1	blood	blood	NOUN
ajst-32269	77	2	lead	lead	NOUN
ajst-32269	77	3	levels	level	NOUN
ajst-32269	77	4	accurately	accurately	ADV
ajst-32269	77	5	reflect	reflect	VERB
ajst-32269	77	6	recent	recent	ADJ
ajst-32269	77	7	lead	lead	NOUN
ajst-32269	77	8	exposure	exposure	NOUN
ajst-32269	77	9	,	,	PUNCT
ajst-32269	77	10	while	while	SCONJ
ajst-32269	77	11	urinary	urinary	ADJ
ajst-32269	77	12	cadmium	cadmium	NOUN
ajst-32269	77	13	concentration	concentration	NOUN
ajst-32269	77	14	is	be	AUX
ajst-32269	77	15	closely	closely	ADV
ajst-32269	77	16	related	relate	VERB
ajst-32269	77	17	to	to	ADP
ajst-32269	77	18	the	the	DET
ajst-32269	77	19	body	body	NOUN
ajst-32269	77	20	's	's	PART
ajst-32269	77	21	cadmium	cadmium	NOUN
ajst-32269	77	22	burden	burden	NOUN
ajst-32269	77	23	.	.	PUNCT
ajst-32269	78	1	large	large	ADJ
ajst-32269	78	2	-	-	PUNCT
ajst-32269	78	3	scale	scale	NOUN
ajst-32269	78	4	epidemiological	epidemiological	ADJ
ajst-32269	78	5	studies	study	NOUN
ajst-32269	78	6	based	base	VERB
ajst-32269	78	7	on	on	ADP
ajst-32269	78	8	these	these	DET
ajst-32269	78	9	biomarkers	biomarker	NOUN
ajst-32269	78	10	have	have	AUX
ajst-32269	78	11	provided	provide	VERB
ajst-32269	78	12	a	a	DET
ajst-32269	78	13	scientific	scientific	ADJ
ajst-32269	78	14	basis	basis	NOUN
ajst-32269	78	15	for	for	ADP
ajst-32269	78	16	establishing	establish	VERB
ajst-32269	78	17	safety	safety	NOUN
ajst-32269	78	18	thresholds	threshold	NOUN
ajst-32269	78	19	for	for	ADP
ajst-32269	78	20	heavy	heavy	ADJ
ajst-32269	78	21	metals	metal	NOUN
ajst-32269	78	22	.	.	PUNCT
ajst-32269	79	1	regarding	regard	VERB
ajst-32269	79	2	effect	effect	NOUN
ajst-32269	79	3	biomarkers	biomarker	NOUN
ajst-32269	79	4	,	,	PUNCT
ajst-32269	79	5	studies	study	NOUN
ajst-32269	79	6	have	have	AUX
ajst-32269	79	7	found	find	VERB
ajst-32269	79	8	that	that	SCONJ
ajst-32269	79	9	lead	lead	NOUN
ajst-32269	79	10	exposure	exposure	NOUN
ajst-32269	79	11	is	be	AUX
ajst-32269	79	12	closely	closely	ADV
ajst-32269	79	13	related	relate	VERB
ajst-32269	79	14	to	to	ADP
ajst-32269	79	15	inhibiting	inhibit	VERB
ajst-32269	79	16	aminolevulinic	aminolevulinic	ADJ
ajst-32269	79	17	acid	acid	NOUN
ajst-32269	79	18	dehydratase	dehydratase	NOUN
ajst-32269	79	19	(	(	PUNCT
ajst-32269	79	20	alad	alad	ADJ
ajst-32269	79	21	)	)	PUNCT
ajst-32269	79	22	activity	activity	NOUN
ajst-32269	79	23	.	.	PUNCT
ajst-32269	80	1	alad	alad	PROPN
ajst-32269	80	2	is	be	AUX
ajst-32269	80	3	a	a	DET
ajst-32269	80	4	key	key	ADJ
ajst-32269	80	5	enzyme	enzyme	NOUN
ajst-32269	80	6	in	in	ADP
ajst-32269	80	7	the	the	DET
ajst-32269	80	8	heme	heme	NOUN
ajst-32269	80	9	synthesis	synthesis	NOUN
ajst-32269	80	10	pathway	pathway	NOUN
ajst-32269	80	11	;	;	PUNCT
ajst-32269	80	12	its	its	PRON
ajst-32269	80	13	inhibition	inhibition	NOUN
ajst-32269	80	14	can	can	AUX
ajst-32269	80	15	lead	lead	VERB
ajst-32269	80	16	to	to	ADP
ajst-32269	80	17	the	the	DET
ajst-32269	80	18	accumulation	accumulation	NOUN
ajst-32269	80	19	of	of	ADP
ajst-32269	80	20	aminolevulinic	aminolevulinic	ADJ
ajst-32269	80	21	acid	acid	NOUN
ajst-32269	80	22	(	(	PUNCT
ajst-32269	80	23	ala	ala	PROPN
ajst-32269	80	24	)	)	PUNCT
ajst-32269	80	25	,	,	PUNCT
ajst-32269	80	26	subsequently	subsequently	ADV
ajst-32269	80	27	causing	cause	VERB
ajst-32269	80	28	oxidative	oxidative	ADJ
ajst-32269	80	29	stress	stress	NOUN
ajst-32269	80	30	and	and	CCONJ
ajst-32269	80	31	neurotoxicity	neurotoxicity	NOUN
ajst-32269	80	32	[	[	X
ajst-32269	80	33	14	14	NUM
ajst-32269	80	34	]	]	PUNCT
ajst-32269	80	35	.	.	PUNCT
ajst-32269	81	1	this	this	DET
ajst-32269	81	2	biomarker	biomarker	NOUN
ajst-32269	81	3	reflects	reflect	VERB
ajst-32269	81	4	the	the	DET
ajst-32269	81	5	biological	biological	ADJ
ajst-32269	81	6	effect	effect	NOUN
ajst-32269	81	7	of	of	ADP
ajst-32269	81	8	lead	lead	NOUN
ajst-32269	81	9	and	and	CCONJ
ajst-32269	81	10	explains	explain	VERB
ajst-32269	81	11	part	part	NOUN
ajst-32269	81	12	of	of	ADP
ajst-32269	81	13	the	the	DET
ajst-32269	81	14	molecular	molecular	ADJ
ajst-32269	81	15	mechanism	mechanism	NOUN
ajst-32269	81	16	of	of	ADP
ajst-32269	81	17	lead	lead	ADJ
ajst-32269	81	18	toxicity	toxicity	NOUN
ajst-32269	81	19	.	.	PUNCT
ajst-32269	82	1	research	research	NOUN
ajst-32269	82	2	on	on	ADP
ajst-32269	82	3	effective	effective	ADJ
ajst-32269	82	4	biomarkers	biomarker	NOUN
ajst-32269	82	5	for	for	ADP
ajst-32269	82	6	cadmium	cadmium	NOUN
ajst-32269	82	7	exposure	exposure	NOUN
ajst-32269	82	8	has	have	AUX
ajst-32269	82	9	also	also	ADV
ajst-32269	82	10	made	make	VERB
ajst-32269	82	11	significant	significant	ADJ
ajst-32269	82	12	progress	progress	NOUN
ajst-32269	82	13	.	.	PUNCT
ajst-32269	83	1	elevated	elevated	ADJ
ajst-32269	83	2	urinary	urinary	ADJ
ajst-32269	83	3	β2	β2	PROPN
ajst-32269	83	4	-	-	PUNCT
ajst-32269	83	5	microglobulin	microglobulin	PROPN
ajst-32269	83	6	and	and	CCONJ
ajst-32269	83	7	n	n	CCONJ
ajst-32269	83	8	-	-	PUNCT
ajst-32269	83	9	acetyl	acetyl	NOUN
ajst-32269	83	10	-	-	PUNCT
ajst-32269	83	11	β	β	NOUN
ajst-32269	83	12	-	-	ADJ
ajst-32269	83	13	d	d	NOUN
ajst-32269	83	14	-	-	NOUN
ajst-32269	83	15	glucosaminidase	glucosaminidase	ADJ
ajst-32269	83	16	(	(	PUNCT
ajst-32269	83	17	nag	nag	NOUN
ajst-32269	83	18	)	)	PUNCT
ajst-32269	83	19	activity	activity	NOUN
ajst-32269	83	20	are	be	AUX
ajst-32269	83	21	sensitive	sensitive	ADJ
ajst-32269	83	22	indicators	indicator	NOUN
ajst-32269	83	23	of	of	ADP
ajst-32269	83	24	cadmium	cadmium	NOUN
ajst-32269	83	25	-	-	PUNCT
ajst-32269	83	26	induced	induce	VERB
ajst-32269	83	27	renal	renal	ADJ
ajst-32269	83	28	tubular	tubular	ADJ
ajst-32269	83	29	damage	damage	NOUN
ajst-32269	83	30	.	.	PUNCT
ajst-32269	84	1	studies	study	NOUN
ajst-32269	84	2	suggest	suggest	VERB
ajst-32269	84	3	that	that	SCONJ
ajst-32269	84	4	urinary	urinary	ADJ
ajst-32269	84	5	nag	nag	VERB
ajst-32269	84	6	>	>	SYM
ajst-32269	84	7	17	17	NUM
ajst-32269	84	8	u	u	NOUN
ajst-32269	84	9	/	/	SYM
ajst-32269	84	10	g	g	NOUN
ajst-32269	84	11	cr	cr	PROPN
ajst-32269	84	12	or	or	CCONJ
ajst-32269	84	13	β2	β2	PROPN
ajst-32269	84	14	-	-	PUNCT
ajst-32269	84	15	mg	mg	PROPN
ajst-32269	84	16	>	>	PROPN
ajst-32269	84	17	1000	1000	NUM
ajst-32269	84	18	μg	μg	PROPN
ajst-32269	84	19	/	/	SYM
ajst-32269	84	20	g	g	PROPN
ajst-32269	84	21	cr	cr	PROPN
ajst-32269	84	22	can	can	AUX
ajst-32269	84	23	be	be	AUX
ajst-32269	84	24	considered	consider	VERB
ajst-32269	84	25	renal	renal	ADJ
ajst-32269	84	26	injury	injury	NOUN
ajst-32269	85	1	[	[	X
ajst-32269	85	2	15	15	NUM
ajst-32269	85	3	]	]	SYM
ajst-32269	85	4	.	.	PUNCT
ajst-32269	86	1	3.3	3.3	NUM
ajst-32269	86	2	environmental	environmental	ADJ
ajst-32269	86	3	endocrine	endocrine	NOUN
ajst-32269	86	4	disruptors	disruptor	NOUN
ajst-32269	86	5	and	and	CCONJ
ajst-32269	86	6	reproductive	reproductive	ADJ
ajst-32269	86	7	health	health	NOUN
ajst-32269	86	8	environmental	environmental	ADJ
ajst-32269	86	9	endocrine	endocrine	NOUN
ajst-32269	86	10	disruptors	disruptor	NOUN
ajst-32269	86	11	(	(	PUNCT
ajst-32269	86	12	edcs	edc	NOUN
ajst-32269	86	13	)	)	PUNCT
ajst-32269	86	14	are	be	AUX
ajst-32269	86	15	a	a	DET
ajst-32269	86	16	class	class	NOUN
ajst-32269	86	17	of	of	ADP
ajst-32269	86	18	exogenous	exogenous	ADJ
ajst-32269	86	19	substances	substance	NOUN
ajst-32269	86	20	that	that	PRON
ajst-32269	86	21	can	can	AUX
ajst-32269	86	22	interfere	interfere	VERB
ajst-32269	86	23	with	with	ADP
ajst-32269	86	24	the	the	DET
ajst-32269	86	25	function	function	NOUN
ajst-32269	86	26	of	of	ADP
ajst-32269	86	27	the	the	DET
ajst-32269	86	28	endocrine	endocrine	NOUN
ajst-32269	86	29	system	system	NOUN
ajst-32269	86	30	,	,	PUNCT
ajst-32269	86	31	including	include	VERB
ajst-32269	86	32	bisphenol	bisphenol	NOUN
ajst-32269	86	33	a	a	DET
ajst-32269	86	34	(	(	PUNCT
ajst-32269	86	35	bpa	bpa	NOUN
ajst-32269	86	36	)	)	PUNCT
ajst-32269	86	37	,	,	PUNCT
ajst-32269	86	38	phthalates	phthalate	NOUN
ajst-32269	86	39	(	(	PUNCT
ajst-32269	86	40	paes	paes	PROPN
ajst-32269	86	41	)	)	PUNCT
ajst-32269	86	42	,	,	PUNCT
ajst-32269	86	43	etc	etc	X
ajst-32269	86	44	.	.	X
ajst-32269	87	1	[	[	X
ajst-32269	87	2	16	16	NUM
ajst-32269	87	3	]	]	PUNCT
ajst-32269	87	4	.	.	PUNCT
ajst-32269	88	1	these	these	DET
ajst-32269	88	2	substances	substance	NOUN
ajst-32269	88	3	are	be	AUX
ajst-32269	88	4	widely	widely	ADV
ajst-32269	88	5	present	present	ADJ
ajst-32269	88	6	in	in	ADP
ajst-32269	88	7	daily	daily	ADJ
ajst-32269	88	8	consumer	consumer	NOUN
ajst-32269	88	9	products	product	NOUN
ajst-32269	88	10	and	and	CCONJ
ajst-32269	88	11	may	may	AUX
ajst-32269	88	12	adversely	adversely	ADV
ajst-32269	88	13	affect	affect	VERB
ajst-32269	88	14	reproductive	reproductive	ADJ
ajst-32269	88	15	health	health	NOUN
ajst-32269	88	16	.	.	PUNCT
ajst-32269	89	1	urinary	urinary	ADJ
ajst-32269	89	2	bpa	bpa	NOUN
ajst-32269	89	3	and	and	CCONJ
ajst-32269	89	4	phthalate	phthalate	NOUN
ajst-32269	89	5	metabolites	metabolite	NOUN
ajst-32269	89	6	(	(	PUNCT
ajst-32269	89	7	such	such	ADJ
ajst-32269	89	8	as	as	ADP
ajst-32269	89	9	mehp	mehp	NOUN
ajst-32269	89	10	and	and	CCONJ
ajst-32269	89	11	mehhp	mehhp	NOUN
ajst-32269	89	12	)	)	PUNCT
ajst-32269	89	13	serve	serve	VERB
ajst-32269	89	14	as	as	ADP
ajst-32269	89	15	reliable	reliable	ADJ
ajst-32269	89	16	biomarkers	biomarker	NOUN
ajst-32269	89	17	of	of	ADP
ajst-32269	89	18	internal	internal	ADJ
ajst-32269	89	19	exposure	exposure	NOUN
ajst-32269	89	20	for	for	ADP
ajst-32269	89	21	assessing	assess	VERB
ajst-32269	89	22	edc	edc	PROPN
ajst-32269	89	23	exposure	exposure	NOUN
ajst-32269	89	24	.	.	PUNCT
ajst-32269	90	1	in	in	ADP
ajst-32269	90	2	terms	term	NOUN
ajst-32269	90	3	of	of	ADP
ajst-32269	90	4	impacts	impact	NOUN
ajst-32269	90	5	on	on	ADP
ajst-32269	90	6	reproductive	reproductive	ADJ
ajst-32269	90	7	health	health	NOUN
ajst-32269	90	8	,	,	PUNCT
ajst-32269	90	9	edc	edc	PROPN
ajst-32269	90	10	exposure	exposure	NOUN
ajst-32269	90	11	is	be	AUX
ajst-32269	90	12	associated	associate	VERB
ajst-32269	90	13	with	with	ADP
ajst-32269	90	14	changes	change	NOUN
ajst-32269	90	15	in	in	ADP
ajst-32269	90	16	semen	semen	NOUN
ajst-32269	90	17	quality	quality	NOUN
ajst-32269	90	18	parameters	parameter	NOUN
ajst-32269	90	19	.	.	PUNCT
ajst-32269	91	1	studies	study	NOUN
ajst-32269	91	2	62	62	NUM
ajst-32269	91	3	have	have	AUX
ajst-32269	91	4	found	find	VERB
ajst-32269	91	5	that	that	SCONJ
ajst-32269	91	6	urinary	urinary	ADJ
ajst-32269	91	7	bpa	bpa	NOUN
ajst-32269	91	8	concentration	concentration	NOUN
ajst-32269	91	9	negatively	negatively	ADV
ajst-32269	91	10	correlates	correlate	VERB
ajst-32269	91	11	with	with	ADP
ajst-32269	91	12	sperm	sperm	NOUN
ajst-32269	91	13	density	density	NOUN
ajst-32269	91	14	,	,	PUNCT
ajst-32269	91	15	motility	motility	NOUN
ajst-32269	91	16	,	,	PUNCT
ajst-32269	91	17	and	and	CCONJ
ajst-32269	91	18	morphological	morphological	ADJ
ajst-32269	91	19	abnormalities	abnormality	NOUN
ajst-32269	91	20	.	.	PUNCT
ajst-32269	92	1	bpa	bpa	NOUN
ajst-32269	92	2	may	may	AUX
ajst-32269	92	3	interfere	interfere	VERB
ajst-32269	92	4	with	with	ADP
ajst-32269	92	5	spermatogenesis	spermatogenesis	NOUN
ajst-32269	92	6	by	by	ADP
ajst-32269	92	7	affecting	affect	VERB
ajst-32269	92	8	estrogen	estrogen	NOUN
ajst-32269	92	9	receptor	receptor	NOUN
ajst-32269	92	10	signaling	signal	VERB
ajst-32269	92	11	pathways	pathway	NOUN
ajst-32269	92	12	and	and	CCONJ
ajst-32269	92	13	epigenetic	epigenetic	ADJ
ajst-32269	92	14	regulation	regulation	NOUN
ajst-32269	92	15	[	[	X
ajst-32269	92	16	17	17	NUM
ajst-32269	92	17	]	]	PUNCT
ajst-32269	92	18	.	.	PUNCT
ajst-32269	93	1	of	of	ADP
ajst-32269	93	2	particular	particular	ADJ
ajst-32269	93	3	concern	concern	NOUN
ajst-32269	93	4	is	be	AUX
ajst-32269	93	5	that	that	SCONJ
ajst-32269	93	6	edc	edc	PROPN
ajst-32269	93	7	exposure	exposure	NOUN
ajst-32269	93	8	may	may	AUX
ajst-32269	93	9	have	have	VERB
ajst-32269	93	10	long	long	ADJ
ajst-32269	93	11	-	-	PUNCT
ajst-32269	93	12	term	term	NOUN
ajst-32269	93	13	effects	effect	NOUN
ajst-32269	93	14	on	on	ADP
ajst-32269	93	15	embryonic	embryonic	ADJ
ajst-32269	93	16	development	development	NOUN
ajst-32269	93	17	and	and	CCONJ
ajst-32269	93	18	child	child	NOUN
ajst-32269	93	19	health	health	NOUN
ajst-32269	93	20	.	.	PUNCT
ajst-32269	94	1	detection	detection	NOUN
ajst-32269	94	2	of	of	ADP
ajst-32269	94	3	edc	edc	PROPN
ajst-32269	94	4	biomarkers	biomarker	NOUN
ajst-32269	94	5	in	in	ADP
ajst-32269	94	6	umbilical	umbilical	ADJ
ajst-32269	94	7	cord	cord	NOUN
ajst-32269	94	8	blood	blood	NOUN
ajst-32269	94	9	shows	show	VERB
ajst-32269	94	10	that	that	SCONJ
ajst-32269	94	11	prenatal	prenatal	ADJ
ajst-32269	94	12	exposure	exposure	NOUN
ajst-32269	94	13	may	may	AUX
ajst-32269	94	14	be	be	AUX
ajst-32269	94	15	associated	associate	VERB
ajst-32269	94	16	with	with	ADP
ajst-32269	94	17	birth	birth	NOUN
ajst-32269	94	18	outcomes	outcome	NOUN
ajst-32269	94	19	and	and	CCONJ
ajst-32269	94	20	child	child	NOUN
ajst-32269	94	21	neurodevelopment	neurodevelopment	ADJ
ajst-32269	94	22	.	.	PUNCT
ajst-32269	95	1	epigenetic	epigenetic	ADJ
ajst-32269	95	2	studies	study	NOUN
ajst-32269	95	3	indicate	indicate	VERB
ajst-32269	95	4	that	that	SCONJ
ajst-32269	95	5	prenatal	prenatal	ADJ
ajst-32269	95	6	edc	edc	PROPN
ajst-32269	95	7	exposure	exposure	NOUN
ajst-32269	95	8	may	may	AUX
ajst-32269	95	9	lead	lead	VERB
ajst-32269	95	10	to	to	ADP
ajst-32269	95	11	changes	change	NOUN
ajst-32269	95	12	in	in	ADP
ajst-32269	95	13	the	the	DET
ajst-32269	95	14	methylation	methylation	NOUN
ajst-32269	95	15	status	status	NOUN
ajst-32269	95	16	of	of	ADP
ajst-32269	95	17	imprinted	imprinted	ADJ
ajst-32269	95	18	genes	gene	NOUN
ajst-32269	95	19	,	,	PUNCT
ajst-32269	95	20	which	which	PRON
ajst-32269	95	21	could	could	AUX
ajst-32269	95	22	be	be	AUX
ajst-32269	95	23	one	one	NUM
ajst-32269	95	24	mechanism	mechanism	NOUN
ajst-32269	95	25	for	for	ADP
ajst-32269	95	26	its	its	PRON
ajst-32269	95	27	long	long	ADJ
ajst-32269	95	28	-	-	PUNCT
ajst-32269	95	29	term	term	NOUN
ajst-32269	95	30	health	health	NOUN
ajst-32269	95	31	effects	effect	NOUN
ajst-32269	95	32	[	[	X
ajst-32269	95	33	18	18	NUM
ajst-32269	95	34	]	]	PUNCT
ajst-32269	95	35	.	.	PUNCT
ajst-32269	96	1	3.4	3.4	NUM
ajst-32269	96	2	case	case	NOUN
ajst-32269	96	3	summary	summary	NOUN
ajst-32269	96	4	analyzing	analyze	VERB
ajst-32269	96	5	these	these	DET
ajst-32269	96	6	typical	typical	ADJ
ajst-32269	96	7	cases	case	NOUN
ajst-32269	96	8	shows	show	VERB
ajst-32269	96	9	that	that	SCONJ
ajst-32269	96	10	molecular	molecular	ADJ
ajst-32269	96	11	biomarkers	biomarker	NOUN
ajst-32269	96	12	are	be	AUX
ajst-32269	96	13	irreplaceable	irreplaceable	ADJ
ajst-32269	96	14	in	in	ADP
ajst-32269	96	15	environmental	environmental	ADJ
ajst-32269	96	16	health	health	NOUN
ajst-32269	96	17	research	research	NOUN
ajst-32269	96	18	.	.	PUNCT
ajst-32269	97	1	they	they	PRON
ajst-32269	97	2	help	help	VERB
ajst-32269	97	3	us	we	PRON
ajst-32269	97	4	better	well	ADV
ajst-32269	97	5	assess	assess	VERB
ajst-32269	97	6	exposure	exposure	NOUN
ajst-32269	97	7	levels	level	NOUN
ajst-32269	97	8	and	and	CCONJ
ajst-32269	97	9	health	health	NOUN
ajst-32269	97	10	risks	risk	NOUN
ajst-32269	97	11	and	and	CCONJ
ajst-32269	97	12	provide	provide	VERB
ajst-32269	97	13	important	important	ADJ
ajst-32269	97	14	clues	clue	NOUN
ajst-32269	97	15	for	for	ADP
ajst-32269	97	16	revealing	reveal	VERB
ajst-32269	97	17	the	the	DET
ajst-32269	97	18	health	health	NOUN
ajst-32269	97	19	damage	damage	NOUN
ajst-32269	97	20	mechanisms	mechanism	NOUN
ajst-32269	97	21	of	of	ADP
ajst-32269	97	22	environmental	environmental	ADJ
ajst-32269	97	23	factors	factor	NOUN
ajst-32269	97	24	.	.	PUNCT
ajst-32269	98	1	with	with	ADP
ajst-32269	98	2	the	the	DET
ajst-32269	98	3	continuous	continuous	ADJ
ajst-32269	98	4	advancement	advancement	NOUN
ajst-32269	98	5	of	of	ADP
ajst-32269	98	6	detection	detection	NOUN
ajst-32269	98	7	technologies	technology	NOUN
ajst-32269	98	8	and	and	CCONJ
ajst-32269	98	9	the	the	DET
ajst-32269	98	10	discovery	discovery	NOUN
ajst-32269	98	11	of	of	ADP
ajst-32269	98	12	new	new	ADJ
ajst-32269	98	13	biomarkers	biomarker	NOUN
ajst-32269	98	14	,	,	PUNCT
ajst-32269	98	15	we	we	PRON
ajst-32269	98	16	are	be	AUX
ajst-32269	98	17	expected	expect	VERB
ajst-32269	98	18	to	to	PART
ajst-32269	98	19	establish	establish	VERB
ajst-32269	98	20	a	a	DET
ajst-32269	98	21	more	more	ADV
ajst-32269	98	22	precise	precise	ADJ
ajst-32269	98	23	environmental	environmental	ADJ
ajst-32269	98	24	health	health	NOUN
ajst-32269	98	25	risk	risk	NOUN
ajst-32269	98	26	assessment	assessment	NOUN
ajst-32269	98	27	and	and	CCONJ
ajst-32269	98	28	early	early	ADJ
ajst-32269	98	29	warning	warning	NOUN
ajst-32269	98	30	system	system	NOUN
ajst-32269	98	31	,	,	PUNCT
ajst-32269	98	32	providing	provide	VERB
ajst-32269	98	33	a	a	DET
ajst-32269	98	34	scientific	scientific	ADJ
ajst-32269	98	35	basis	basis	NOUN
ajst-32269	98	36	for	for	ADP
ajst-32269	98	37	formulating	formulate	VERB
ajst-32269	98	38	effective	effective	ADJ
ajst-32269	98	39	preventive	preventive	ADJ
ajst-32269	98	40	measures	measure	NOUN
ajst-32269	98	41	.	.	PUNCT
ajst-32269	99	1	future	future	ADJ
ajst-32269	99	2	research	research	NOUN
ajst-32269	99	3	needs	need	VERB
ajst-32269	99	4	to	to	PART
ajst-32269	99	5	strengthen	strengthen	VERB
ajst-32269	99	6	the	the	DET
ajst-32269	99	7	integrated	integrate	VERB
ajst-32269	99	8	application	application	NOUN
ajst-32269	99	9	of	of	ADP
ajst-32269	99	10	multi	multi	ADJ
ajst-32269	99	11	-	-	ADJ
ajst-32269	99	12	omics	omics	ADJ
ajst-32269	99	13	technologies	technology	NOUN
ajst-32269	99	14	further	far	ADV
ajst-32269	99	15	and	and	CCONJ
ajst-32269	99	16	promote	promote	VERB
ajst-32269	99	17	the	the	DET
ajst-32269	99	18	translation	translation	NOUN
ajst-32269	99	19	of	of	ADP
ajst-32269	99	20	molecular	molecular	ADJ
ajst-32269	99	21	biomarkers	biomarker	NOUN
ajst-32269	99	22	from	from	ADP
ajst-32269	99	23	research	research	NOUN
ajst-32269	99	24	to	to	ADP
ajst-32269	99	25	public	public	ADJ
ajst-32269	99	26	health	health	NOUN
ajst-32269	99	27	practice	practice	NOUN
ajst-32269	99	28	.	.	PUNCT
ajst-32269	100	1	4	4	X
ajst-32269	100	2	.	.	X
ajst-32269	100	3	challenges	challenge	NOUN
ajst-32269	100	4	and	and	CCONJ
ajst-32269	100	5	limitations	limitation	NOUN
ajst-32269	100	6	although	although	SCONJ
ajst-32269	100	7	molecular	molecular	ADJ
ajst-32269	100	8	biomarkers	biomarker	NOUN
ajst-32269	100	9	show	show	VERB
ajst-32269	100	10	great	great	ADJ
ajst-32269	100	11	potential	potential	NOUN
ajst-32269	100	12	in	in	ADP
ajst-32269	100	13	environmental	environmental	ADJ
ajst-32269	100	14	health	health	NOUN
ajst-32269	100	15	research	research	NOUN
ajst-32269	100	16	,	,	PUNCT
ajst-32269	100	17	their	their	PRON
ajst-32269	100	18	application	application	NOUN
ajst-32269	100	19	still	still	ADV
ajst-32269	100	20	faces	face	VERB
ajst-32269	100	21	many	many	ADJ
ajst-32269	100	22	challenges	challenge	NOUN
ajst-32269	100	23	and	and	CCONJ
ajst-32269	100	24	limitations	limitation	NOUN
ajst-32269	100	25	.	.	PUNCT
ajst-32269	101	1	4.1	4.1	NUM
ajst-32269	101	2	technical	technical	ADJ
ajst-32269	101	3	standardization	standardization	NOUN
ajst-32269	101	4	challenges	challenge	VERB
ajst-32269	101	5	different	different	ADJ
ajst-32269	101	6	laboratories	laboratory	NOUN
ajst-32269	101	7	use	use	VERB
ajst-32269	101	8	varying	vary	VERB
ajst-32269	101	9	detection	detection	NOUN
ajst-32269	101	10	methods	method	NOUN
ajst-32269	101	11	,	,	PUNCT
ajst-32269	101	12	instrument	instrument	NOUN
ajst-32269	101	13	platforms	platform	NOUN
ajst-32269	101	14	,	,	PUNCT
ajst-32269	101	15	and	and	CCONJ
ajst-32269	101	16	operating	operating	NOUN
ajst-32269	101	17	procedures	procedure	NOUN
ajst-32269	101	18	,	,	PUNCT
ajst-32269	101	19	making	make	VERB
ajst-32269	101	20	comparing	compare	VERB
ajst-32269	101	21	and	and	CCONJ
ajst-32269	101	22	integrating	integrate	VERB
ajst-32269	101	23	results	result	NOUN
ajst-32269	101	24	directly	directly	ADV
ajst-32269	101	25	difficult	difficult	ADJ
ajst-32269	101	26	.	.	PUNCT
ajst-32269	102	1	for	for	ADP
ajst-32269	102	2	example	example	NOUN
ajst-32269	102	3	,	,	PUNCT
ajst-32269	102	4	slight	slight	ADJ
ajst-32269	102	5	differences	difference	NOUN
ajst-32269	102	6	in	in	ADP
ajst-32269	102	7	pre	pre	ADJ
ajst-32269	102	8	-	-	ADJ
ajst-32269	102	9	processing	processing	ADJ
ajst-32269	102	10	steps	step	NOUN
ajst-32269	102	11	,	,	PUNCT
ajst-32269	102	12	such	such	ADJ
ajst-32269	102	13	as	as	ADP
ajst-32269	102	14	the	the	DET
ajst-32269	102	15	collection	collection	NOUN
ajst-32269	102	16	,	,	PUNCT
ajst-32269	102	17	transport	transport	NOUN
ajst-32269	102	18	,	,	PUNCT
ajst-32269	102	19	and	and	CCONJ
ajst-32269	102	20	storage	storage	NOUN
ajst-32269	102	21	conditions	condition	NOUN
ajst-32269	102	22	of	of	ADP
ajst-32269	102	23	biological	biological	ADJ
ajst-32269	102	24	samples	sample	NOUN
ajst-32269	102	25	,	,	PUNCT
ajst-32269	102	26	can	can	AUX
ajst-32269	102	27	significantly	significantly	ADV
ajst-32269	102	28	affect	affect	VERB
ajst-32269	102	29	the	the	DET
ajst-32269	102	30	stability	stability	NOUN
ajst-32269	102	31	of	of	ADP
ajst-32269	102	32	biomarkers	biomarker	NOUN
ajst-32269	102	33	and	and	CCONJ
ajst-32269	102	34	the	the	DET
ajst-32269	102	35	detection	detection	NOUN
ajst-32269	102	36	results	result	VERB
ajst-32269	102	37	.	.	PUNCT
ajst-32269	103	1	4.2	4.2	NUM
ajst-32269	103	2	complexity	complexity	NOUN
ajst-32269	103	3	of	of	ADP
ajst-32269	103	4	biological	biological	ADJ
ajst-32269	103	5	interpretation	interpretation	NOUN
ajst-32269	103	6	a	a	DET
ajst-32269	103	7	single	single	ADJ
ajst-32269	103	8	biomarker	biomarker	NOUN
ajst-32269	103	9	often	often	ADV
ajst-32269	103	10	lacks	lack	VERB
ajst-32269	103	11	specificity	specificity	NOUN
ajst-32269	103	12	;	;	PUNCT
ajst-32269	103	13	multiple	multiple	ADJ
ajst-32269	103	14	exposure	exposure	NOUN
ajst-32269	103	15	factors	factor	NOUN
ajst-32269	103	16	can	can	AUX
ajst-32269	103	17	cause	cause	VERB
ajst-32269	103	18	the	the	DET
ajst-32269	103	19	same	same	ADJ
ajst-32269	103	20	biomarker	biomarker	NOUN
ajst-32269	103	21	,	,	PUNCT
ajst-32269	103	22	and	and	CCONJ
ajst-32269	103	23	conversely	conversely	ADV
ajst-32269	103	24	,	,	PUNCT
ajst-32269	103	25	the	the	DET
ajst-32269	103	26	same	same	ADJ
ajst-32269	103	27	exposure	exposure	NOUN
ajst-32269	103	28	can	can	AUX
ajst-32269	103	29	lead	lead	VERB
ajst-32269	103	30	to	to	ADP
ajst-32269	103	31	changes	change	NOUN
ajst-32269	103	32	in	in	ADP
ajst-32269	103	33	multiple	multiple	ADJ
ajst-32269	103	34	biomarkers	biomarker	NOUN
ajst-32269	103	35	.	.	PUNCT
ajst-32269	104	1	this	this	DET
ajst-32269	104	2	many	many	ADJ
ajst-32269	104	3	-	-	PUNCT
ajst-32269	104	4	to	to	ADP
ajst-32269	104	5	-	-	PUNCT
ajst-32269	104	6	many	many	ADJ
ajst-32269	104	7	relationship	relationship	NOUN
ajst-32269	104	8	makes	make	VERB
ajst-32269	104	9	causal	causal	ADJ
ajst-32269	104	10	inference	inference	NOUN
ajst-32269	104	11	difficult	difficult	ADJ
ajst-32269	104	12	.	.	PUNCT
ajst-32269	105	1	furthermore	furthermore	ADV
ajst-32269	105	2	,	,	PUNCT
ajst-32269	105	3	genetic	genetic	ADJ
ajst-32269	105	4	background	background	NOUN
ajst-32269	105	5	,	,	PUNCT
ajst-32269	105	6	age	age	NOUN
ajst-32269	105	7	,	,	PUNCT
ajst-32269	105	8	gender	gender	NOUN
ajst-32269	105	9	,	,	PUNCT
ajst-32269	105	10	and	and	CCONJ
ajst-32269	105	11	lifestyle	lifestyle	NOUN
ajst-32269	105	12	among	among	ADP
ajst-32269	105	13	individuals	individual	NOUN
ajst-32269	105	14	can	can	AUX
ajst-32269	105	15	influence	influence	VERB
ajst-32269	105	16	biomarkers	biomarker	NOUN
ajst-32269	105	17	'	'	PART
ajst-32269	105	18	baseline	baseline	NOUN
ajst-32269	105	19	levels	level	NOUN
ajst-32269	105	20	and	and	CCONJ
ajst-32269	105	21	response	response	NOUN
ajst-32269	105	22	,	,	PUNCT
ajst-32269	105	23	posing	pose	VERB
ajst-32269	105	24	challenges	challenge	NOUN
ajst-32269	105	25	for	for	ADP
ajst-32269	105	26	result	result	NOUN
ajst-32269	105	27	interpretation	interpretation	NOUN
ajst-32269	105	28	.	.	PUNCT
ajst-32269	106	1	4.3	4.3	NUM
ajst-32269	106	2	barriers	barrier	NOUN
ajst-32269	106	3	to	to	ADP
ajst-32269	106	4	translational	translational	ADJ
ajst-32269	106	5	application	application	NOUN
ajst-32269	106	6	translating	translate	VERB
ajst-32269	106	7	laboratory	laboratory	NOUN
ajst-32269	106	8	research	research	NOUN
ajst-32269	106	9	findings	finding	NOUN
ajst-32269	106	10	into	into	ADP
ajst-32269	106	11	public	public	ADJ
ajst-32269	106	12	health	health	NOUN
ajst-32269	106	13	practice	practice	NOUN
ajst-32269	106	14	requires	require	VERB
ajst-32269	106	15	overcoming	overcome	VERB
ajst-32269	106	16	numerous	numerous	ADJ
ajst-32269	106	17	bottlenecks	bottleneck	NOUN
ajst-32269	106	18	.	.	PUNCT
ajst-32269	107	1	issues	issue	NOUN
ajst-32269	107	2	such	such	ADJ
ajst-32269	107	3	as	as	ADP
ajst-32269	107	4	the	the	DET
ajst-32269	107	5	cost	cost	NOUN
ajst-32269	107	6	-	-	PUNCT
ajst-32269	107	7	effectiveness	effectiveness	NOUN
ajst-32269	107	8	of	of	ADP
ajst-32269	107	9	large	large	ADJ
ajst-32269	107	10	-	-	PUNCT
ajst-32269	107	11	scale	scale	NOUN
ajst-32269	107	12	population	population	NOUN
ajst-32269	107	13	screening	screening	NOUN
ajst-32269	107	14	,	,	PUNCT
ajst-32269	107	15	the	the	DET
ajst-32269	107	16	standardization	standardization	NOUN
ajst-32269	107	17	and	and	CCONJ
ajst-32269	107	18	quality	quality	NOUN
ajst-32269	107	19	control	control	NOUN
ajst-32269	107	20	of	of	ADP
ajst-32269	107	21	biomarker	biomarker	NOUN
ajst-32269	107	22	detection	detection	NOUN
ajst-32269	107	23	,	,	PUNCT
ajst-32269	107	24	and	and	CCONJ
ajst-32269	107	25	how	how	SCONJ
ajst-32269	107	26	to	to	PART
ajst-32269	107	27	establish	establish	VERB
ajst-32269	107	28	health	health	NOUN
ajst-32269	107	29	risk	risk	NOUN
ajst-32269	107	30	evaluation	evaluation	NOUN
ajst-32269	107	31	standards	standard	NOUN
ajst-32269	107	32	based	base	VERB
ajst-32269	107	33	on	on	ADP
ajst-32269	107	34	biomarkers	biomarker	NOUN
ajst-32269	107	35	all	all	PRON
ajst-32269	107	36	need	need	VERB
ajst-32269	107	37	urgent	urgent	ADJ
ajst-32269	107	38	solutions	solution	NOUN
ajst-32269	107	39	.	.	PUNCT
ajst-32269	108	1	meanwhile	meanwhile	ADV
ajst-32269	108	2	,	,	PUNCT
ajst-32269	108	3	biomarker	biomarker	NOUN
ajst-32269	108	4	research	research	NOUN
ajst-32269	108	5	also	also	ADV
ajst-32269	108	6	involves	involve	VERB
ajst-32269	108	7	ethical	ethical	ADJ
ajst-32269	108	8	issues	issue	NOUN
ajst-32269	108	9	,	,	PUNCT
ajst-32269	108	10	such	such	ADJ
ajst-32269	108	11	as	as	ADP
ajst-32269	108	12	individual	individual	ADJ
ajst-32269	108	13	privacy	privacy	NOUN
ajst-32269	108	14	protection	protection	NOUN
ajst-32269	108	15	,	,	PUNCT
ajst-32269	108	16	the	the	DET
ajst-32269	108	17	responsibility	responsibility	NOUN
ajst-32269	108	18	of	of	ADP
ajst-32269	108	19	reporting	reporting	NOUN
ajst-32269	108	20	results	result	NOUN
ajst-32269	108	21	,	,	PUNCT
ajst-32269	108	22	and	and	CCONJ
ajst-32269	108	23	potential	potential	ADJ
ajst-32269	108	24	genetic	genetic	ADJ
ajst-32269	108	25	discrimination	discrimination	NOUN
ajst-32269	108	26	.	.	PUNCT
ajst-32269	109	1	4.4	4.4	NUM
ajst-32269	109	2	limited	limit	VERB
ajst-32269	109	3	ability	ability	NOUN
ajst-32269	109	4	to	to	PART
ajst-32269	109	5	assess	assess	VERB
ajst-32269	109	6	complex	complex	ADJ
ajst-32269	109	7	mixture	mixture	NOUN
ajst-32269	109	8	exposures	exposure	NOUN
ajst-32269	109	9	environmental	environmental	ADJ
ajst-32269	109	10	exposure	exposure	NOUN
ajst-32269	109	11	is	be	AUX
ajst-32269	109	12	a	a	DET
ajst-32269	109	13	complex	complex	ADJ
ajst-32269	109	14	mixture	mixture	NOUN
ajst-32269	109	15	of	of	ADP
ajst-32269	109	16	multiple	multiple	ADJ
ajst-32269	109	17	coexisting	coexist	VERB
ajst-32269	109	18	pollutants	pollutant	NOUN
ajst-32269	109	19	.	.	PUNCT
ajst-32269	110	1	current	current	ADJ
ajst-32269	110	2	research	research	NOUN
ajst-32269	110	3	primarily	primarily	ADV
ajst-32269	110	4	focuses	focus	VERB
ajst-32269	110	5	on	on	ADP
ajst-32269	110	6	single	single	ADJ
ajst-32269	110	7	or	or	CCONJ
ajst-32269	110	8	a	a	DET
ajst-32269	110	9	few	few	ADJ
ajst-32269	110	10	biomarkers	biomarker	NOUN
ajst-32269	110	11	,	,	PUNCT
ajst-32269	110	12	making	make	VERB
ajst-32269	110	13	it	it	PRON
ajst-32269	110	14	difficult	difficult	ADJ
ajst-32269	110	15	to	to	PART
ajst-32269	110	16	reflect	reflect	VERB
ajst-32269	110	17	the	the	DET
ajst-32269	110	18	effects	effect	NOUN
ajst-32269	110	19	of	of	ADP
ajst-32269	110	20	mixed	mixed	ADJ
ajst-32269	110	21	exposures	exposure	NOUN
ajst-32269	110	22	and	and	CCONJ
ajst-32269	110	23	their	their	PRON
ajst-32269	110	24	interactions	interaction	NOUN
ajst-32269	110	25	comprehensively	comprehensively	ADV
ajst-32269	110	26	.	.	PUNCT
ajst-32269	111	1	although	although	SCONJ
ajst-32269	111	2	omics	omics	PROPN
ajst-32269	111	3	technologies	technology	NOUN
ajst-32269	111	4	provide	provide	VERB
ajst-32269	111	5	a	a	DET
ajst-32269	111	6	panoramic	panoramic	ADJ
ajst-32269	111	7	view	view	NOUN
ajst-32269	111	8	,	,	PUNCT
ajst-32269	111	9	methodological	methodological	ADJ
ajst-32269	111	10	breakthroughs	breakthrough	NOUN
ajst-32269	111	11	are	be	AUX
ajst-32269	111	12	still	still	ADV
ajst-32269	111	13	needed	need	VERB
ajst-32269	111	14	to	to	PART
ajst-32269	111	15	filter	filter	VERB
ajst-32269	111	16	out	out	ADP
ajst-32269	111	17	key	key	ADJ
ajst-32269	111	18	biomarkers	biomarker	NOUN
ajst-32269	111	19	with	with	ADP
ajst-32269	111	20	public	public	ADJ
ajst-32269	111	21	health	health	NOUN
ajst-32269	111	22	significance	significance	NOUN
ajst-32269	111	23	from	from	ADP
ajst-32269	111	24	massive	massive	ADJ
ajst-32269	111	25	amounts	amount	NOUN
ajst-32269	111	26	of	of	ADP
ajst-32269	111	27	data	datum	NOUN
ajst-32269	111	28	and	and	CCONJ
ajst-32269	111	29	verify	verify	VERB
ajst-32269	111	30	their	their	PRON
ajst-32269	111	31	utility	utility	NOUN
ajst-32269	111	32	.	.	PUNCT
ajst-32269	112	1	63	63	NUM
ajst-32269	112	2	5	5	NUM
ajst-32269	112	3	.	.	PUNCT
ajst-32269	112	4	conclusion	conclusion	VERB
ajst-32269	112	5	the	the	DET
ajst-32269	112	6	core	core	NOUN
ajst-32269	112	7	problem	problem	NOUN
ajst-32269	112	8	currently	currently	ADV
ajst-32269	112	9	facing	face	VERB
ajst-32269	112	10	research	research	NOUN
ajst-32269	112	11	is	be	AUX
ajst-32269	112	12	how	how	SCONJ
ajst-32269	112	13	to	to	PART
ajst-32269	112	14	effectively	effectively	ADV
ajst-32269	112	15	translate	translate	VERB
ajst-32269	112	16	the	the	DET
ajst-32269	112	17	findings	finding	NOUN
ajst-32269	112	18	of	of	ADP
ajst-32269	112	19	molecular	molecular	ADJ
ajst-32269	112	20	biomarker	biomarker	NOUN
ajst-32269	112	21	research	research	NOUN
ajst-32269	112	22	into	into	ADP
ajst-32269	112	23	public	public	ADJ
ajst-32269	112	24	health	health	NOUN
ajst-32269	112	25	practice	practice	NOUN
ajst-32269	112	26	.	.	PUNCT
ajst-32269	113	1	solutions	solution	NOUN
ajst-32269	113	2	should	should	AUX
ajst-32269	113	3	focus	focus	VERB
ajst-32269	113	4	on	on	ADP
ajst-32269	113	5	three	three	NUM
ajst-32269	113	6	aspects	aspect	NOUN
ajst-32269	113	7	:	:	PUNCT
ajst-32269	113	8	promote	promote	VERB
ajst-32269	113	9	the	the	DET
ajst-32269	113	10	integrated	integrate	VERB
ajst-32269	113	11	application	application	NOUN
ajst-32269	113	12	of	of	ADP
ajst-32269	113	13	multi	multi	ADJ
ajst-32269	113	14	-	-	ADJ
ajst-32269	113	15	omics	omics	ADJ
ajst-32269	113	16	technologies	technology	NOUN
ajst-32269	113	17	and	and	CCONJ
ajst-32269	113	18	establish	establish	VERB
ajst-32269	113	19	standardized	standardized	ADJ
ajst-32269	113	20	detection	detection	NOUN
ajst-32269	113	21	processes	process	NOUN
ajst-32269	113	22	and	and	CCONJ
ajst-32269	113	23	data	datum	NOUN
ajst-32269	113	24	interpretation	interpretation	NOUN
ajst-32269	113	25	norms	norm	NOUN
ajst-32269	113	26	to	to	PART
ajst-32269	113	27	address	address	VERB
ajst-32269	113	28	technical	technical	ADJ
ajst-32269	113	29	heterogeneity	heterogeneity	NOUN
ajst-32269	113	30	.	.	PUNCT
ajst-32269	114	1	secondly	secondly	ADV
ajst-32269	114	2	,	,	PUNCT
ajst-32269	114	3	interdisciplinary	interdisciplinary	ADJ
ajst-32269	114	4	collaboration	collaboration	NOUN
ajst-32269	114	5	should	should	AUX
ajst-32269	114	6	be	be	AUX
ajst-32269	114	7	strengthened	strengthen	VERB
ajst-32269	114	8	,	,	PUNCT
ajst-32269	114	9	uniting	unite	VERB
ajst-32269	114	10	epidemiology	epidemiology	NOUN
ajst-32269	114	11	,	,	PUNCT
ajst-32269	114	12	biostatistics	biostatistic	NOUN
ajst-32269	114	13	,	,	PUNCT
ajst-32269	114	14	and	and	CCONJ
ajst-32269	114	15	public	public	ADJ
ajst-32269	114	16	health	health	NOUN
ajst-32269	114	17	experts	expert	NOUN
ajst-32269	114	18	to	to	PART
ajst-32269	114	19	jointly	jointly	ADV
ajst-32269	114	20	develop	develop	VERB
ajst-32269	114	21	health	health	NOUN
ajst-32269	114	22	risk	risk	NOUN
ajst-32269	114	23	assessment	assessment	NOUN
ajst-32269	114	24	systems	system	NOUN
ajst-32269	114	25	and	and	CCONJ
ajst-32269	114	26	early	early	ADJ
ajst-32269	114	27	warning	warning	NOUN
ajst-32269	114	28	models	model	NOUN
ajst-32269	114	29	based	base	VERB
ajst-32269	114	30	on	on	ADP
ajst-32269	114	31	biomarkers	biomarker	NOUN
ajst-32269	114	32	.	.	PUNCT
ajst-32269	115	1	finally	finally	ADV
ajst-32269	115	2	,	,	PUNCT
ajst-32269	115	3	promote	promote	VERB
ajst-32269	115	4	policy	policy	NOUN
ajst-32269	115	5	translation	translation	NOUN
ajst-32269	115	6	research	research	NOUN
ajst-32269	115	7	,	,	PUNCT
ajst-32269	115	8	explore	explore	VERB
ajst-32269	115	9	practical	practical	ADJ
ajst-32269	115	10	application	application	NOUN
ajst-32269	115	11	pathways	pathway	NOUN
ajst-32269	115	12	for	for	ADP
ajst-32269	115	13	biomarkers	biomarker	NOUN
ajst-32269	115	14	in	in	ADP
ajst-32269	115	15	setting	set	VERB
ajst-32269	115	16	environmental	environmental	ADJ
ajst-32269	115	17	health	health	NOUN
ajst-32269	115	18	standards	standard	NOUN
ajst-32269	115	19	,	,	PUNCT
ajst-32269	115	20	identifying	identify	VERB
ajst-32269	115	21	high	high	ADJ
ajst-32269	115	22	-	-	PUNCT
ajst-32269	115	23	risk	risk	NOUN
ajst-32269	115	24	populations	population	NOUN
ajst-32269	115	25	,	,	PUNCT
ajst-32269	115	26	and	and	CCONJ
ajst-32269	115	27	evaluating	evaluate	VERB
ajst-32269	115	28	intervention	intervention	NOUN
ajst-32269	115	29	effects	effect	NOUN
ajst-32269	115	30	,	,	PUNCT
ajst-32269	115	31	ultimately	ultimately	ADV
ajst-32269	115	32	achieving	achieve	VERB
ajst-32269	115	33	the	the	DET
ajst-32269	115	34	leap	leap	NOUN
ajst-32269	115	35	from	from	ADP
ajst-32269	115	36	basic	basic	ADJ
ajst-32269	115	37	research	research	NOUN
ajst-32269	115	38	to	to	ADP
ajst-32269	115	39	public	public	ADJ
ajst-32269	115	40	health	health	NOUN
ajst-32269	115	41	action	action	NOUN
ajst-32269	115	42	.	.	PUNCT
ajst-32269	116	1	references	reference	NOUN
ajst-32269	116	2	[	[	X
ajst-32269	116	3	1	1	NUM
ajst-32269	116	4	]	]	X
ajst-32269	116	5	zhou	zhou	PROPN
ajst-32269	116	6	,	,	PUNCT
ajst-32269	116	7	r.	r.	PROPN
ajst-32269	116	8	,	,	PUNCT
ajst-32269	116	9	hu	hu	PROPN
ajst-32269	116	10	,	,	PUNCT
ajst-32269	116	11	j.	j.	PROPN
ajst-32269	116	12	l.	l.	PROPN
ajst-32269	116	13	,	,	PUNCT
ajst-32269	116	14	wang	wang	PROPN
ajst-32269	116	15	,	,	PUNCT
ajst-32269	116	16	s.	s.	PROPN
ajst-32269	116	17	,	,	PUNCT
ajst-32269	116	18	et	et	PROPN
ajst-32269	116	19	al	al	PROPN
ajst-32269	116	20	.	.	PROPN
ajst-32269	116	21	(	(	PUNCT
ajst-32269	116	22	2023	2023	NUM
ajst-32269	116	23	)	)	PUNCT
ajst-32269	116	24	.	.	PUNCT
ajst-32269	117	1	research	research	NOUN
ajst-32269	117	2	progress	progress	NOUN
ajst-32269	117	3	on	on	ADP
ajst-32269	117	4	the	the	DET
ajst-32269	117	5	detection	detection	NOUN
ajst-32269	117	6	technology	technology	NOUN
ajst-32269	117	7	of	of	ADP
ajst-32269	117	8	cotinine	cotinine	NOUN
ajst-32269	117	9	in	in	ADP
ajst-32269	117	10	biological	biological	ADJ
ajst-32269	117	11	samples	sample	NOUN
ajst-32269	117	12	.	.	PUNCT
ajst-32269	118	1	anhui	anhui	PROPN
ajst-32269	118	2	medical	medical	PROPN
ajst-32269	118	3	journal	journal	PROPN
ajst-32269	118	4	,	,	PUNCT
ajst-32269	118	5	44(12	44(12	NUM
ajst-32269	118	6	)	)	PUNCT
ajst-32269	118	7	,	,	PUNCT
ajst-32269	118	8	1525	1525	NUM
ajst-32269	118	9	-	-	SYM
ajst-32269	118	10	1530	1530	NUM
ajst-32269	118	11	.	.	PUNCT
ajst-32269	119	1	[	[	X
ajst-32269	119	2	in	in	ADP
ajst-32269	119	3	chinese	chinese	PROPN
ajst-32269	119	4	]	]	PUNCT
ajst-32269	119	5	[	[	X
ajst-32269	119	6	2	2	NUM
ajst-32269	119	7	]	]	X
ajst-32269	119	8	zhang	zhang	PROPN
ajst-32269	119	9	,	,	PUNCT
ajst-32269	119	10	z.	z.	PROPN
ajst-32269	119	11	b.	b.	PROPN
ajst-32269	119	12	,	,	PUNCT
ajst-32269	119	13	li	li	PROPN
ajst-32269	119	14	,	,	PUNCT
ajst-32269	119	15	y.	y.	PROPN
ajst-32269	119	16	,	,	PUNCT
ajst-32269	119	17	&	&	CCONJ
ajst-32269	119	18	xia	xia	PROPN
ajst-32269	119	19	,	,	PUNCT
ajst-32269	119	20	z.	z.	PROPN
ajst-32269	119	21	l.	l.	PROPN
ajst-32269	119	22	(	(	PUNCT
ajst-32269	119	23	2005	2005	NUM
ajst-32269	119	24	)	)	PUNCT
ajst-32269	119	25	.	.	PUNCT
ajst-32269	120	1	effect	effect	NOUN
ajst-32269	120	2	biomarkers	biomarker	NOUN
ajst-32269	120	3	and	and	CCONJ
ajst-32269	120	4	risk	risk	NOUN
ajst-32269	120	5	assessment	assessment	NOUN
ajst-32269	120	6	.	.	PUNCT
ajst-32269	121	1	occupational	occupational	ADJ
ajst-32269	121	2	health	health	NOUN
ajst-32269	121	3	and	and	CCONJ
ajst-32269	121	4	emergency	emergency	NOUN
ajst-32269	121	5	rescue	rescue	NOUN
ajst-32269	121	6	,	,	PUNCT
ajst-32269	121	7	(	(	PUNCT
ajst-32269	121	8	01	01	NUM
ajst-32269	121	9	)	)	PUNCT
ajst-32269	121	10	,	,	PUNCT
ajst-32269	121	11	15	15	NUM
ajst-32269	121	12	-	-	SYM
ajst-32269	121	13	17	17	NUM
ajst-32269	121	14	.	.	PUNCT
ajst-32269	122	1	[	[	X
ajst-32269	122	2	in	in	ADP
ajst-32269	122	3	chinese	chinese	PROPN
ajst-32269	122	4	]	]	PUNCT
ajst-32269	122	5	[	[	X
ajst-32269	122	6	3	3	NUM
ajst-32269	122	7	]	]	PUNCT
ajst-32269	122	8	langone	langone	NOUN
ajst-32269	122	9	,	,	PUNCT
ajst-32269	122	10	j.	j.	PROPN
ajst-32269	122	11	j.	j.	PROPN
ajst-32269	122	12	,	,	PUNCT
ajst-32269	122	13	gjika	gjika	PROPN
ajst-32269	122	14	,	,	PUNCT
ajst-32269	122	15	h.	h.	PROPN
ajst-32269	122	16	b.	b.	PROPN
ajst-32269	122	17	,	,	PUNCT
ajst-32269	122	18	&	&	CCONJ
ajst-32269	122	19	van	van	PROPN
ajst-32269	122	20	vunakis	vunakis	PROPN
ajst-32269	122	21	,	,	PUNCT
ajst-32269	122	22	h.	h.	PROPN
ajst-32269	122	23	(	(	PUNCT
ajst-32269	122	24	1999	1999	NUM
ajst-32269	122	25	)	)	PUNCT
ajst-32269	122	26	.	.	PUNCT
ajst-32269	123	1	analytical	analytical	ADJ
ajst-32269	123	2	determination	determination	NOUN
ajst-32269	123	3	of	of	ADP
ajst-32269	123	4	nicotine	nicotine	NOUN
ajst-32269	123	5	and	and	CCONJ
ajst-32269	123	6	related	related	ADJ
ajst-32269	123	7	compounds	compound	NOUN
ajst-32269	123	8	and	and	CCONJ
ajst-32269	123	9	their	their	PRON
ajst-32269	123	10	metabolites	metabolite	NOUN
ajst-32269	123	11	.	.	PUNCT
ajst-32269	124	1	elsevier	elsevier	NOUN
ajst-32269	124	2	,	,	PUNCT
ajst-32269	124	3	amsterdam	amsterdam	PROPN
ajst-32269	124	4	.	.	PUNCT
ajst-32269	125	1	[	[	X
ajst-32269	125	2	4	4	NUM
ajst-32269	125	3	]	]	SYM
ajst-32269	125	4	pellegrini	pellegrini	PROPN
ajst-32269	125	5	,	,	PUNCT
ajst-32269	125	6	m.	m.	NOUN
ajst-32269	125	7	,	,	PUNCT
ajst-32269	125	8	marchei	marchei	PROPN
ajst-32269	125	9	,	,	PUNCT
ajst-32269	125	10	e.	e.	PROPN
ajst-32269	125	11	,	,	PUNCT
ajst-32269	125	12	rossi	rossi	PROPN
ajst-32269	125	13	,	,	PUNCT
ajst-32269	125	14	s.	s.	PROPN
ajst-32269	125	15	,	,	PUNCT
ajst-32269	125	16	et	et	PROPN
ajst-32269	125	17	al	al	PROPN
ajst-32269	125	18	.	.	PUNCT
ajst-32269	125	19	(	(	PUNCT
ajst-32269	125	20	2007	2007	NUM
ajst-32269	125	21	)	)	PUNCT
ajst-32269	125	22	.	.	PUNCT
ajst-32269	126	1	liquid	liquid	ADJ
ajst-32269	126	2	chromatography	chromatography	NOUN
ajst-32269	126	3	/	/	SYM
ajst-32269	126	4	electrospray	electrospray	NOUN
ajst-32269	126	5	ionization	ionization	NOUN
ajst-32269	126	6	tandem	tandem	PROPN
ajst-32269	126	7	mass	mass	PROPN
ajst-32269	126	8	spectrometry	spectrometry	NOUN
ajst-32269	126	9	assay	assay	VERB
ajst-32269	126	10	for	for	ADP
ajst-32269	126	11	the	the	DET
ajst-32269	126	12	determination	determination	NOUN
ajst-32269	126	13	of	of	ADP
ajst-32269	126	14	nicotine	nicotine	NOUN
ajst-32269	126	15	and	and	CCONJ
ajst-32269	126	16	its	its	PRON
ajst-32269	126	17	metabolites	metabolite	NOUN
ajst-32269	126	18	,	,	PUNCT
ajst-32269	126	19	caffeine	caffeine	NOUN
ajst-32269	126	20	and	and	CCONJ
ajst-32269	126	21	arecoline	arecoline	NOUN
ajst-32269	126	22	in	in	ADP
ajst-32269	126	23	breast	breast	NOUN
ajst-32269	126	24	milk	milk	NOUN
ajst-32269	126	25	.	.	PUNCT
ajst-32269	127	1	rapid	rapid	ADJ
ajst-32269	127	2	communications	communication	NOUN
ajst-32269	127	3	in	in	ADP
ajst-32269	127	4	mass	mass	ADJ
ajst-32269	127	5	spectrometry	spectrometry	NOUN
ajst-32269	127	6	,	,	PUNCT
ajst-32269	127	7	21	21	NUM
ajst-32269	127	8	,	,	PUNCT
ajst-32269	127	9	2693	2693	NUM
ajst-32269	127	10	-	-	SYM
ajst-32269	127	11	2703	2703	NUM
ajst-32269	127	12	.	.	PUNCT
ajst-32269	128	1	[	[	X
ajst-32269	128	2	5	5	NUM
ajst-32269	128	3	]	]	X
ajst-32269	128	4	kim	kim	PROPN
ajst-32269	128	5	,	,	PUNCT
ajst-32269	128	6	i.	i.	PROPN
ajst-32269	128	7	,	,	PUNCT
ajst-32269	128	8	darwin	darwin	PROPN
ajst-32269	128	9	,	,	PUNCT
ajst-32269	128	10	w.	w.	PROPN
ajst-32269	128	11	d.	d.	PROPN
ajst-32269	128	12	,	,	PUNCT
ajst-32269	128	13	&	&	CCONJ
ajst-32269	128	14	huestis	huestis	PROPN
ajst-32269	128	15	,	,	PUNCT
ajst-32269	128	16	m.	m.	NOUN
ajst-32269	128	17	a.	a.	NOUN
ajst-32269	128	18	(	(	PUNCT
ajst-32269	128	19	2005	2005	NUM
ajst-32269	128	20	)	)	PUNCT
ajst-32269	128	21	.	.	PUNCT
ajst-32269	129	1	simultaneous	simultaneous	ADJ
ajst-32269	129	2	determination	determination	NOUN
ajst-32269	129	3	of	of	ADP
ajst-32269	129	4	nicotine	nicotine	NOUN
ajst-32269	129	5	,	,	PUNCT
ajst-32269	129	6	cotinine	cotinine	NOUN
ajst-32269	129	7	,	,	PUNCT
ajst-32269	129	8	norcotinine	norcotinine	NOUN
ajst-32269	129	9	,	,	PUNCT
ajst-32269	129	10	and	and	CCONJ
ajst-32269	129	11	trans-3'-hydroxycotinine	trans-3'-hydroxycotinine	PROPN
ajst-32269	129	12	in	in	ADP
ajst-32269	129	13	human	human	ADJ
ajst-32269	129	14	oral	oral	ADJ
ajst-32269	129	15	fluid	fluid	NOUN
ajst-32269	129	16	using	use	VERB
ajst-32269	129	17	solid	solid	ADJ
ajst-32269	129	18	phase	phase	NOUN
ajst-32269	129	19	extraction	extraction	NOUN
ajst-32269	129	20	and	and	CCONJ
ajst-32269	129	21	gas	gas	NOUN
ajst-32269	129	22	chromatography	chromatography	NOUN
ajst-32269	129	23	-	-	PUNCT
ajst-32269	129	24	mass	mass	NOUN
ajst-32269	129	25	spectrometry	spectrometry	NOUN
ajst-32269	129	26	.	.	PUNCT
ajst-32269	130	1	journal	journal	PROPN
ajst-32269	130	2	of	of	ADP
ajst-32269	130	3	chromatography	chromatography	PROPN
ajst-32269	130	4	b	b	PROPN
ajst-32269	130	5	,	,	PUNCT
ajst-32269	130	6	814	814	NUM
ajst-32269	130	7	,	,	PUNCT
ajst-32269	130	8	233	233	NUM
ajst-32269	130	9	-	-	SYM
ajst-32269	130	10	240	240	NUM
ajst-32269	130	11	.	.	PUNCT
ajst-32269	131	1	[	[	X
ajst-32269	131	2	6	6	NUM
ajst-32269	131	3	]	]	X
ajst-32269	131	4	fan	fan	PROPN
ajst-32269	131	5	,	,	PUNCT
ajst-32269	131	6	z.	z.	PROPN
ajst-32269	131	7	,	,	PUNCT
ajst-32269	131	8	liu	liu	PROPN
ajst-32269	131	9	,	,	PUNCT
ajst-32269	131	10	h.	h.	PROPN
ajst-32269	131	11	m.	m.	PROPN
ajst-32269	131	12	,	,	PUNCT
ajst-32269	131	13	xie	xie	PROPN
ajst-32269	131	14	,	,	PUNCT
ajst-32269	131	15	f.	f.	PROPN
ajst-32269	131	16	w.	w.	PROPN
ajst-32269	131	17	,	,	PUNCT
ajst-32269	131	18	et	et	PROPN
ajst-32269	131	19	al	al	PROPN
ajst-32269	131	20	.	.	PUNCT
ajst-32269	132	1	(	(	PUNCT
ajst-32269	132	2	2008	2008	NUM
ajst-32269	132	3	)	)	PUNCT
ajst-32269	132	4	.	.	PUNCT
ajst-32269	133	1	determination	determination	NOUN
ajst-32269	133	2	of	of	ADP
ajst-32269	133	3	nicotine	nicotine	NOUN
ajst-32269	133	4	and	and	CCONJ
ajst-32269	133	5	its	its	PRON
ajst-32269	133	6	metabolites	metabolite	NOUN
ajst-32269	133	7	in	in	ADP
ajst-32269	133	8	urine	urine	NOUN
ajst-32269	133	9	of	of	ADP
ajst-32269	133	10	smokers	smoker	NOUN
ajst-32269	133	11	and	and	CCONJ
ajst-32269	133	12	passive	passive	ADJ
ajst-32269	133	13	smokers	smoker	NOUN
ajst-32269	133	14	by	by	ADP
ajst-32269	133	15	lc	lc	PROPN
ajst-32269	133	16	-	-	PUNCT
ajst-32269	133	17	ms	ms	PROPN
ajst-32269	133	18	/	/	SYM
ajst-32269	133	19	ms	ms	PROPN
ajst-32269	133	20	.	.	PROPN
ajst-32269	133	21	tobacco	tobacco	PROPN
ajst-32269	133	22	science	science	PROPN
ajst-32269	133	23	&	&	CCONJ
ajst-32269	133	24	technology	technology	PROPN
ajst-32269	133	25	,	,	PUNCT
ajst-32269	133	26	(	(	PUNCT
ajst-32269	133	27	09	09	NUM
ajst-32269	133	28	)	)	PUNCT
ajst-32269	133	29	,	,	PUNCT
ajst-32269	133	30	39	39	NUM
ajst-32269	133	31	-	-	SYM
ajst-32269	133	32	44	44	NUM
ajst-32269	133	33	.	.	PUNCT
ajst-32269	134	1	[	[	X
ajst-32269	134	2	in	in	ADP
ajst-32269	134	3	chinese	chinese	PROPN
ajst-32269	134	4	]	]	X
ajst-32269	135	1	[	[	X
ajst-32269	135	2	7	7	NUM
ajst-32269	135	3	]	]	X
ajst-32269	135	4	klaassen	klaassen	NOUN
ajst-32269	135	5	,	,	PUNCT
ajst-32269	135	6	c.	c.	PROPN
ajst-32269	135	7	d.	d.	PROPN
ajst-32269	135	8	,	,	PUNCT
ajst-32269	135	9	&	&	CCONJ
ajst-32269	135	10	casarett	casarett	PROPN
ajst-32269	135	11	,	,	PUNCT
ajst-32269	135	12	l.	l.	PROPN
ajst-32269	135	13	j.	j.	PROPN
ajst-32269	135	14	,	,	PUNCT
ajst-32269	135	15	doull	doull	PROPN
ajst-32269	135	16	,	,	PUNCT
ajst-32269	135	17	j.	j.	PROPN
ajst-32269	135	18	(	(	PUNCT
ajst-32269	135	19	2002	2002	NUM
ajst-32269	135	20	)	)	PUNCT
ajst-32269	135	21	.	.	PUNCT
ajst-32269	136	1	toxicology	toxicology	NOUN
ajst-32269	136	2	(	(	PUNCT
ajst-32269	136	3	chinese	chinese	ADJ
ajst-32269	136	4	translation	translation	NOUN
ajst-32269	136	5	)	)	PUNCT
ajst-32269	136	6	.	.	PUNCT
ajst-32269	137	1	people	people	NOUN
ajst-32269	137	2	's	's	PART
ajst-32269	137	3	medical	medical	ADJ
ajst-32269	137	4	publishing	publishing	PROPN
ajst-32269	137	5	house	house	PROPN
ajst-32269	137	6	,	,	PUNCT
ajst-32269	137	7	beijing	beijing	PROPN
ajst-32269	137	8	.	.	PUNCT
ajst-32269	138	1	p1019	p1019	PROPN
ajst-32269	138	2	.	.	PUNCT
ajst-32269	139	1	[	[	X
ajst-32269	139	2	8	8	NUM
ajst-32269	139	3	]	]	X
ajst-32269	139	4	zhang	zhang	PROPN
ajst-32269	139	5	,	,	PUNCT
ajst-32269	139	6	z.	z.	PROPN
ajst-32269	139	7	b.	b.	PROPN
ajst-32269	139	8	,	,	PUNCT
ajst-32269	139	9	li	li	PROPN
ajst-32269	139	10	,	,	PUNCT
ajst-32269	139	11	y.	y.	PROPN
ajst-32269	139	12	,	,	PUNCT
ajst-32269	139	13	&	&	CCONJ
ajst-32269	139	14	xia	xia	PROPN
ajst-32269	139	15	,	,	PUNCT
ajst-32269	139	16	z.	z.	PROPN
ajst-32269	139	17	l.	l.	PROPN
ajst-32269	139	18	(	(	PUNCT
ajst-32269	139	19	2005	2005	NUM
ajst-32269	139	20	)	)	PUNCT
ajst-32269	139	21	.	.	PUNCT
ajst-32269	140	1	effect	effect	NOUN
ajst-32269	140	2	biomarkers	biomarker	NOUN
ajst-32269	140	3	and	and	CCONJ
ajst-32269	140	4	risk	risk	NOUN
ajst-32269	140	5	assessment	assessment	NOUN
ajst-32269	140	6	.	.	PUNCT
ajst-32269	141	1	occupational	occupational	ADJ
ajst-32269	141	2	health	health	NOUN
ajst-32269	141	3	and	and	CCONJ
ajst-32269	141	4	emergency	emergency	NOUN
ajst-32269	141	5	rescue	rescue	NOUN
ajst-32269	141	6	,	,	PUNCT
ajst-32269	141	7	(	(	PUNCT
ajst-32269	141	8	01	01	NUM
ajst-32269	141	9	)	)	PUNCT
ajst-32269	141	10	,	,	PUNCT
ajst-32269	141	11	15	15	NUM
ajst-32269	141	12	-	-	SYM
ajst-32269	141	13	17	17	NUM
ajst-32269	141	14	.	.	PUNCT
ajst-32269	142	1	[	[	X
ajst-32269	142	2	in	in	ADP
ajst-32269	142	3	chinese	chinese	PROPN
ajst-32269	142	4	]	]	PUNCT
ajst-32269	142	5	[	[	X
ajst-32269	142	6	9	9	NUM
ajst-32269	142	7	]	]	X
ajst-32269	142	8	zhuang	zhuang	PROPN
ajst-32269	142	9	,	,	PUNCT
ajst-32269	142	10	z.	z.	PROPN
ajst-32269	142	11	x.	x.	PROPN
ajst-32269	142	12	(	(	PUNCT
ajst-32269	142	13	1999	1999	NUM
ajst-32269	142	14	)	)	PUNCT
ajst-32269	142	15	.	.	PUNCT
ajst-32269	143	1	application	application	NOUN
ajst-32269	143	2	of	of	ADP
ajst-32269	143	3	molecular	molecular	ADJ
ajst-32269	143	4	biomarkers	biomarker	NOUN
ajst-32269	143	5	in	in	ADP
ajst-32269	143	6	occupational	occupational	ADJ
ajst-32269	143	7	medicine	medicine	NOUN
ajst-32269	143	8	.	.	PUNCT
ajst-32269	144	1	chinese	chinese	ADJ
ajst-32269	144	2	journal	journal	PROPN
ajst-32269	144	3	of	of	ADP
ajst-32269	144	4	industrial	industrial	ADJ
ajst-32269	144	5	medicine	medicine	NOUN
ajst-32269	144	6	,	,	PUNCT
ajst-32269	144	7	(	(	PUNCT
ajst-32269	144	8	01	01	NUM
ajst-32269	144	9	)	)	PUNCT
ajst-32269	144	10	,	,	PUNCT
ajst-32269	144	11	61	61	NUM
ajst-32269	144	12	-	-	SYM
ajst-32269	144	13	64	64	NUM
ajst-32269	144	14	.	.	PUNCT
ajst-32269	145	1	[	[	X
ajst-32269	145	2	in	in	ADP
ajst-32269	145	3	chinese	chinese	PROPN
ajst-32269	145	4	]	]	X
ajst-32269	146	1	[	[	X
ajst-32269	146	2	10	10	NUM
ajst-32269	146	3	]	]	X
ajst-32269	146	4	han	han	PROPN
ajst-32269	146	5	,	,	PUNCT
ajst-32269	146	6	j.	j.	PROPN
ajst-32269	146	7	w.	w.	PROPN
ajst-32269	146	8	,	,	PUNCT
ajst-32269	146	9	&	&	CCONJ
ajst-32269	146	10	zhang	zhang	PROPN
ajst-32269	146	11	,	,	PUNCT
ajst-32269	146	12	x.	x.	PROPN
ajst-32269	146	13	j.	j.	PROPN
ajst-32269	146	14	(	(	PUNCT
ajst-32269	146	15	2011	2011	NUM
ajst-32269	146	16	)	)	PUNCT
ajst-32269	146	17	.	.	PUNCT
ajst-32269	147	1	status	status	NOUN
ajst-32269	147	2	of	of	ADP
ajst-32269	147	3	genome	genome	NOUN
ajst-32269	147	4	-	-	PUNCT
ajst-32269	147	5	wide	wide	ADJ
ajst-32269	147	6	association	association	NOUN
ajst-32269	147	7	studies	study	NOUN
ajst-32269	147	8	.	.	PUNCT
ajst-32269	148	1	hereditas	hereditas	PROPN
ajst-32269	148	2	(	(	PUNCT
ajst-32269	148	3	beijing	beijing	PROPN
ajst-32269	148	4	)	)	PUNCT
ajst-32269	148	5	,	,	PUNCT
ajst-32269	148	6	33(1	33(1	NUM
ajst-32269	148	7	)	)	PUNCT
ajst-32269	148	8	,	,	PUNCT
ajst-32269	148	9	25	25	NUM
ajst-32269	148	10	-	-	SYM
ajst-32269	148	11	35	35	NUM
ajst-32269	148	12	.	.	PUNCT
ajst-32269	149	1	[	[	X
ajst-32269	149	2	in	in	ADP
ajst-32269	149	3	chinese	chinese	PROPN
ajst-32269	149	4	]	]	PUNCT
ajst-32269	150	1	[	[	X
ajst-32269	150	2	11	11	NUM
ajst-32269	150	3	]	]	X
ajst-32269	150	4	zheng	zheng	PROPN
ajst-32269	150	5	,	,	PUNCT
ajst-32269	150	6	s.	s.	PROPN
ajst-32269	150	7	j.	j.	PROPN
ajst-32269	150	8	(	(	PUNCT
ajst-32269	150	9	2019	2019	NUM
ajst-32269	150	10	)	)	PUNCT
ajst-32269	150	11	.	.	PUNCT
ajst-32269	151	1	cell	cell	NOUN
ajst-32269	151	2	type	type	NOUN
ajst-32269	151	3	heterogeneity	heterogeneity	NOUN
ajst-32269	151	4	in	in	ADP
ajst-32269	151	5	epigenome	epigenome	NOUN
ajst-32269	151	6	-	-	PUNCT
ajst-32269	151	7	wide	wide	ADJ
ajst-32269	151	8	association	association	NOUN
ajst-32269	151	9	studies	study	NOUN
ajst-32269	151	10	[	[	X
ajst-32269	151	11	phd	phd	NOUN
ajst-32269	151	12	dissertation	dissertation	NOUN
ajst-32269	151	13	]	]	PUNCT
ajst-32269	151	14	.	.	PUNCT
ajst-32269	152	1	shanghai	shanghai	PROPN
ajst-32269	152	2	institute	institute	PROPN
ajst-32269	152	3	of	of	ADP
ajst-32269	152	4	nutrition	nutrition	PROPN
ajst-32269	152	5	and	and	CCONJ
ajst-32269	152	6	health	health	NOUN
ajst-32269	152	7	,	,	PUNCT
ajst-32269	152	8	chinese	chinese	PROPN
ajst-32269	152	9	academy	academy	PROPN
ajst-32269	152	10	of	of	ADP
ajst-32269	152	11	sciences	sciences	PROPN
ajst-32269	152	12	.	.	PUNCT
ajst-32269	153	1	doi	doi	NOUN
ajst-32269	153	2	:	:	PUNCT
ajst-32269	153	3	10.27981	10.27981	NUM
ajst-32269	153	4	/	/	SYM
ajst-32269	153	5	d.	d.	PROPN
ajst-32269	153	6	cnki	cnki	PROPN
ajst-32269	153	7	.	.	PUNCT
ajst-32269	153	8	gzdgc	gzdgc	PROPN
ajst-32269	153	9	.	.	PUNCT
ajst-32269	154	1	2019.000039	2019.000039	NOUN
ajst-32269	154	2	.	.	PUNCT
ajst-32269	155	1	[	[	X
ajst-32269	155	2	in	in	ADP
ajst-32269	155	3	chinese	chinese	PROPN
ajst-32269	155	4	]	]	PUNCT
ajst-32269	155	5	[	[	X
ajst-32269	155	6	12	12	NUM
ajst-32269	155	7	]	]	PUNCT
ajst-32269	155	8	argos	argo	NOUN
ajst-32269	155	9	,	,	PUNCT
ajst-32269	155	10	m.	m.	NOUN
ajst-32269	155	11	(	(	PUNCT
ajst-32269	155	12	2015	2015	NUM
ajst-32269	155	13	)	)	PUNCT
ajst-32269	155	14	.	.	PUNCT
ajst-32269	156	1	arsenic	arsenic	ADJ
ajst-32269	156	2	exposure	exposure	NOUN
ajst-32269	156	3	and	and	CCONJ
ajst-32269	156	4	epigenetic	epigenetic	ADJ
ajst-32269	156	5	alterations	alteration	NOUN
ajst-32269	156	6	:	:	PUNCT
ajst-32269	156	7	recent	recent	ADJ
ajst-32269	156	8	findings	finding	NOUN
ajst-32269	156	9	based	base	VERB
ajst-32269	156	10	on	on	ADP
ajst-32269	156	11	the	the	DET
ajst-32269	156	12	illumina	illumina	PROPN
ajst-32269	156	13	450k	450k	PROPN
ajst-32269	156	14	dna	dna	PROPN
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ajst-32269	156	16	array	array	NOUN
ajst-32269	156	17	.	.	PUNCT
ajst-32269	157	1	current	current	ADJ
ajst-32269	157	2	environmental	environmental	ADJ
ajst-32269	157	3	health	health	NOUN
ajst-32269	157	4	reports	report	NOUN
ajst-32269	157	5	,	,	PUNCT
ajst-32269	157	6	2(2	2(2	NUM
ajst-32269	157	7	)	)	PUNCT
ajst-32269	157	8	,	,	PUNCT
ajst-32269	157	9	137	137	NUM
ajst-32269	157	10	-	-	SYM
ajst-32269	157	11	144	144	NUM
ajst-32269	157	12	.	.	PUNCT
ajst-32269	158	1	[	[	X
ajst-32269	158	2	13	13	NUM
ajst-32269	158	3	]	]	SYM
ajst-32269	158	4	li	li	PROPN
ajst-32269	158	5	,	,	PUNCT
ajst-32269	158	6	p.	p.	PROPN
ajst-32269	158	7	h.	h.	PROPN
ajst-32269	158	8	(	(	PUNCT
ajst-32269	158	9	2013	2013	NUM
ajst-32269	158	10	)	)	PUNCT
ajst-32269	158	11	.	.	PUNCT
ajst-32269	159	1	correlative	correlative	ADJ
ajst-32269	159	2	study	study	NOUN
ajst-32269	159	3	on	on	ADP
ajst-32269	159	4	exposure	exposure	NOUN
ajst-32269	159	5	to	to	ADP
ajst-32269	159	6	pahs	pah	NOUN
ajst-32269	159	7	in	in	ADP
ajst-32269	159	8	atmospheric	atmospheric	ADJ
ajst-32269	159	9	fine	fine	ADJ
ajst-32269	159	10	particles	particle	NOUN
ajst-32269	159	11	and	and	CCONJ
ajst-32269	159	12	metabolic	metabolic	NOUN
ajst-32269	159	13	markers	marker	NOUN
ajst-32269	159	14	in	in	ADP
ajst-32269	159	15	the	the	DET
ajst-32269	159	16	elderly	elderly	ADJ
ajst-32269	159	17	[	[	X
ajst-32269	159	18	phd	phd	NOUN
ajst-32269	159	19	dissertation	dissertation	NOUN
ajst-32269	159	20	]	]	PUNCT
ajst-32269	159	21	.	.	PUNCT
ajst-32269	160	1	nankai	nankai	PROPN
ajst-32269	160	2	university	university	PROPN
ajst-32269	160	3	.	.	PUNCT
ajst-32269	161	1	[	[	X
ajst-32269	161	2	in	in	ADP
ajst-32269	161	3	chinese	chinese	PROPN
ajst-32269	161	4	]	]	PUNCT
ajst-32269	161	5	[	[	X
ajst-32269	161	6	14	14	NUM
ajst-32269	161	7	]	]	PUNCT
ajst-32269	161	8	he	he	PRON
ajst-32269	161	9	,	,	PUNCT
ajst-32269	161	10	y.	y.	PROPN
ajst-32269	161	11	,	,	PUNCT
ajst-32269	161	12	wang	wang	PROPN
ajst-32269	161	13	,	,	PUNCT
ajst-32269	161	14	k.	k.	PROPN
ajst-32269	161	15	,	,	PUNCT
ajst-32269	161	16	pang	pang	NOUN
ajst-32269	161	17	,	,	PUNCT
ajst-32269	161	18	y.	y.	PROPN
ajst-32269	161	19	,	,	PUNCT
ajst-32269	161	20	et	et	PROPN
ajst-32269	161	21	al	al	PROPN
ajst-32269	161	22	.	.	PROPN
ajst-32269	161	23	(	(	PUNCT
ajst-32269	161	24	2020	2020	NUM
ajst-32269	161	25	)	)	PUNCT
ajst-32269	161	26	.	.	PUNCT
ajst-32269	162	1	relationship	relationship	NOUN
ajst-32269	162	2	between	between	ADP
ajst-32269	162	3	related	related	ADJ
ajst-32269	162	4	gene	gene	NOUN
ajst-32269	162	5	methylation	methylation	NOUN
ajst-32269	162	6	and	and	CCONJ
ajst-32269	162	7	genetic	genetic	ADJ
ajst-32269	162	8	damage	damage	NOUN
ajst-32269	162	9	in	in	ADP
ajst-32269	162	10	lead	lead	NOUN
ajst-32269	162	11	-	-	PUNCT
ajst-32269	162	12	exposed	expose	VERB
ajst-32269	162	13	workers	worker	NOUN
ajst-32269	162	14	.	.	PUNCT
ajst-32269	163	1	chinese	chinese	ADJ
ajst-32269	163	2	journal	journal	PROPN
ajst-32269	163	3	of	of	ADP
ajst-32269	163	4	industrial	industrial	ADJ
ajst-32269	163	5	medicine	medicine	NOUN
ajst-32269	163	6	,	,	PUNCT
ajst-32269	163	7	33(4	33(4	NUM
ajst-32269	163	8	)	)	PUNCT
ajst-32269	163	9	,	,	PUNCT
ajst-32269	163	10	304	304	NUM
ajst-32269	163	11	-	-	SYM
ajst-32269	163	12	308	308	NUM
ajst-32269	163	13	+	+	NOUN
ajst-32269	163	14	385	385	NUM
ajst-32269	163	15	.	.	PUNCT
ajst-32269	164	1	doi	doi	NOUN
ajst-32269	164	2	:	:	PUNCT
ajst-32269	164	3	10.13631	10.13631	NUM
ajst-32269	164	4	/	/	SYM
ajst-32269	164	5	j.cnki.zggyyx.2020.04.004	j.cnki.zggyyx.2020.04.004	PROPN
ajst-32269	164	6	.	.	PUNCT
ajst-32269	165	1	[	[	X
ajst-32269	165	2	in	in	ADP
ajst-32269	165	3	chinese	chinese	PROPN
ajst-32269	165	4	]	]	X
ajst-32269	165	5	[	[	X
ajst-32269	165	6	15	15	NUM
ajst-32269	165	7	]	]	X
ajst-32269	165	8	state	state	NOUN
ajst-32269	165	9	bureau	bureau	NOUN
ajst-32269	165	10	of	of	ADP
ajst-32269	165	11	technical	technical	ADJ
ajst-32269	165	12	supervision	supervision	NOUN
ajst-32269	165	13	.	.	PUNCT
ajst-32269	166	1	(	(	PUNCT
ajst-32269	166	2	1998	1998	NUM
ajst-32269	166	3	)	)	PUNCT
ajst-32269	166	4	.	.	PUNCT
ajst-32269	167	1	gb	gb	X
ajst-32269	167	2	/	/	SYM
ajst-32269	167	3	t	t	NOUN
ajst-32269	167	4	17221	17221	NUM
ajst-32269	167	5	-	-	SYM
ajst-32269	167	6	1998	1998	NUM
ajst-32269	167	7	determination	determination	NOUN
ajst-32269	167	8	standard	standard	NOUN
ajst-32269	167	9	of	of	ADP
ajst-32269	167	10	health	health	PROPN
ajst-32269	167	11	hazard	hazard	NOUN
ajst-32269	167	12	area	area	NOUN
ajst-32269	167	13	of	of	ADP
ajst-32269	167	14	environmental	environmental	ADJ
ajst-32269	167	15	cadmium	cadmium	NOUN
ajst-32269	167	16	pollution	pollution	NOUN
ajst-32269	167	17	.	.	PUNCT
ajst-32269	168	1	standards	standard	NOUN
ajst-32269	168	2	press	press	PROPN
ajst-32269	168	3	of	of	ADP
ajst-32269	168	4	china	china	PROPN
ajst-32269	168	5	,	,	PUNCT
ajst-32269	168	6	beijing	beijing	PROPN
ajst-32269	168	7	.	.	PUNCT
ajst-32269	169	1	[	[	X
ajst-32269	169	2	in	in	ADP
ajst-32269	169	3	chinese	chinese	PROPN
ajst-32269	169	4	]	]	X
ajst-32269	169	5	[	[	X
ajst-32269	169	6	16	16	NUM
ajst-32269	169	7	]	]	X
ajst-32269	169	8	qian	qian	PROPN
ajst-32269	169	9	,	,	PUNCT
ajst-32269	169	10	y.	y.	PROPN
ajst-32269	169	11	h.	h.	PROPN
ajst-32269	169	12	,	,	PUNCT
ajst-32269	169	13	&	&	CCONJ
ajst-32269	169	14	liu	liu	PROPN
ajst-32269	169	15	,	,	PUNCT
ajst-32269	169	16	x.	x.	PROPN
ajst-32269	169	17	y.	y.	PROPN
ajst-32269	169	18	(	(	PUNCT
ajst-32269	169	19	2011	2011	NUM
ajst-32269	169	20	)	)	PUNCT
ajst-32269	169	21	.	.	PUNCT
ajst-32269	170	1	environmental	environmental	ADJ
ajst-32269	170	2	issues	issue	NOUN
ajst-32269	170	3	of	of	ADP
ajst-32269	170	4	edcs	edc	VERB
ajst-32269	170	5	chemicals	chemical	NOUN
ajst-32269	170	6	.	.	PUNCT
ajst-32269	171	1	northern	northern	ADJ
ajst-32269	171	2	environment	environment	PROPN
ajst-32269	171	3	,	,	PUNCT
ajst-32269	171	4	23(07	23(07	NUM
ajst-32269	171	5	)	)	PUNCT
ajst-32269	171	6	,	,	PUNCT
ajst-32269	171	7	12	12	NUM
ajst-32269	171	8	-	-	SYM
ajst-32269	171	9	13	13	NUM
ajst-32269	171	10	.	.	PUNCT
ajst-32269	172	1	[	[	X
ajst-32269	172	2	in	in	ADP
ajst-32269	172	3	chinese	chinese	PROPN
ajst-32269	172	4	]	]	PUNCT
ajst-32269	172	5	64	64	NUM
ajst-32269	172	6	[	[	X
ajst-32269	172	7	17	17	NUM
ajst-32269	172	8	]	]	X
ajst-32269	172	9	ma	ma	PROPN
ajst-32269	172	10	,	,	PUNCT
ajst-32269	172	11	y.	y.	PROPN
ajst-32269	172	12	c.	c.	PROPN
ajst-32269	172	13	,	,	PUNCT
ajst-32269	172	14	zhong	zhong	PROPN
ajst-32269	172	15	,	,	PUNCT
ajst-32269	172	16	j.	j.	PROPN
ajst-32269	172	17	,	,	PUNCT
ajst-32269	172	18	gao	gao	PROPN
ajst-32269	172	19	,	,	PUNCT
ajst-32269	172	20	j.	j.	PROPN
ajst-32269	172	21	w.	w.	PROPN
ajst-32269	172	22	,	,	PUNCT
ajst-32269	172	23	et	et	PROPN
ajst-32269	172	24	al	al	PROPN
ajst-32269	172	25	.	.	PROPN
ajst-32269	172	26	(	(	PUNCT
ajst-32269	172	27	2025	2025	NUM
ajst-32269	172	28	)	)	PUNCT
ajst-32269	172	29	.	.	PUNCT
ajst-32269	173	1	research	research	NOUN
ajst-32269	173	2	progress	progress	NOUN
ajst-32269	173	3	on	on	ADP
ajst-32269	173	4	the	the	DET
ajst-32269	173	5	effects	effect	NOUN
ajst-32269	173	6	of	of	ADP
ajst-32269	173	7	environmental	environmental	ADJ
ajst-32269	173	8	endocrine	endocrine	NOUN
ajst-32269	173	9	disruptors	disruptor	NOUN
ajst-32269	173	10	on	on	ADP
ajst-32269	173	11	sperm	sperm	NOUN
ajst-32269	173	12	.	.	PUNCT
ajst-32269	174	1	chinese	chinese	ADJ
ajst-32269	174	2	journal	journal	PROPN
ajst-32269	174	3	of	of	ADP
ajst-32269	174	4	human	human	ADJ
ajst-32269	174	5	sexuality	sexuality	NOUN
ajst-32269	174	6	,	,	PUNCT
ajst-32269	174	7	34(08	34(08	PROPN
ajst-32269	174	8	)	)	PUNCT
ajst-32269	174	9	,	,	PUNCT
ajst-32269	174	10	14	14	NUM
ajst-32269	174	11	-	-	SYM
ajst-32269	174	12	18	18	NUM
ajst-32269	174	13	.	.	PUNCT
ajst-32269	175	1	[	[	X
ajst-32269	175	2	in	in	ADP
ajst-32269	175	3	chinese	chinese	PROPN
ajst-32269	175	4	]	]	X
ajst-32269	175	5	[	[	X
ajst-32269	175	6	18	18	NUM
ajst-32269	175	7	]	]	SYM
ajst-32269	175	8	li	li	PROPN
ajst-32269	175	9	,	,	PUNCT
ajst-32269	175	10	j.	j.	PROPN
ajst-32269	175	11	,	,	PUNCT
ajst-32269	175	12	&	&	CCONJ
ajst-32269	175	13	si	si	PROPN
ajst-32269	175	14	,	,	PUNCT
ajst-32269	175	15	j.	j.	PROPN
ajst-32269	175	16	l.	l.	PROPN
ajst-32269	175	17	(	(	PUNCT
ajst-32269	175	18	2002	2002	NUM
ajst-32269	175	19	)	)	PUNCT
ajst-32269	175	20	.	.	PUNCT
ajst-32269	176	1	introduction	introduction	NOUN
ajst-32269	176	2	to	to	ADP
ajst-32269	176	3	environmental	environmental	ADJ
ajst-32269	176	4	endocrine	endocrine	NOUN
ajst-32269	176	5	disrupting	disrupt	VERB
ajst-32269	176	6	chemicals	chemical	NOUN
ajst-32269	176	7	.	.	PUNCT
ajst-32269	177	1	journal	journal	PROPN
ajst-32269	177	2	of	of	ADP
ajst-32269	177	3	environment	environment	NOUN
ajst-32269	177	4	and	and	CCONJ
ajst-32269	177	5	health	health	NOUN
ajst-32269	177	6	,	,	PUNCT
ajst-32269	177	7	(	(	PUNCT
ajst-32269	177	8	01	01	NUM
ajst-32269	177	9	)	)	PUNCT
ajst-32269	177	10	,	,	PUNCT
ajst-32269	177	11	83	83	NUM
ajst-32269	177	12	-	-	SYM
ajst-32269	177	13	84	84	NUM
ajst-32269	177	14	.	.	PUNCT
ajst-32269	178	1	doi	doi	NOUN
ajst-32269	178	2	:	:	PUNCT
ajst-32269	178	3	10.16241	10.16241	NUM
ajst-32269	178	4	/	/	SYM
ajst-32269	178	5	j.cnki.1001	j.cnki.1001	NOUN
ajst-32269	178	6	-	-	PUNCT
ajst-32269	178	7	5914.2002.01.060	5914.2002.01.060	NOUN
ajst-32269	178	8	.	.	PUNCT
ajst-32269	179	1	[	[	X
ajst-32269	179	2	in	in	ADP
ajst-32269	179	3	chinese	chinese	PROPN
ajst-32269	179	4	]	]	PUNCT