id	sid	tid	token	lemma	pos
ajst-32481	1	1	98	98	NUM
ajst-32481	1	2	the	the	DET
ajst-32481	1	3	gut	gut	NOUN
ajst-32481	1	4	microbiome	microbiome	NOUN
ajst-32481	1	5	in	in	ADP
ajst-32481	1	6	alzheimer	alzheimer	PROPN
ajst-32481	1	7	’s	’s	PART
ajst-32481	1	8	disease	disease	NOUN
ajst-32481	1	9	:	:	PUNCT
ajst-32481	1	10	research	research	NOUN
ajst-32481	1	11	progress	progress	NOUN
ajst-32481	1	12	and	and	CCONJ
ajst-32481	1	13	perspectives	perspective	NOUN
ajst-32481	1	14	junwen	junwen	ADJ
ajst-32481	1	15	sha	sha	PROPN
ajst-32481	1	16	*	*	PROPN
ajst-32481	1	17	school	school	NOUN
ajst-32481	1	18	of	of	ADP
ajst-32481	1	19	life	life	NOUN
ajst-32481	1	20	sciences	science	NOUN
ajst-32481	1	21	and	and	CCONJ
ajst-32481	1	22	biotechnology	biotechnology	NOUN
ajst-32481	1	23	,	,	PUNCT
ajst-32481	1	24	shanghai	shanghai	PROPN
ajst-32481	1	25	jiao	jiao	PROPN
ajst-32481	1	26	tong	tong	PROPN
ajst-32481	1	27	university	university	PROPN
ajst-32481	1	28	,	,	PUNCT
ajst-32481	1	29	shanghai	shanghai	PROPN
ajst-32481	1	30	,	,	PUNCT
ajst-32481	1	31	china	china	PROPN
ajst-32481	1	32	*	*	PUNCT
ajst-32481	1	33	corresponding	correspond	VERB
ajst-32481	1	34	author	author	NOUN
ajst-32481	1	35	email	email	NOUN
ajst-32481	1	36	:	:	PUNCT
ajst-32481	1	37	tenkiisha0126@sjtu.edu.cn	tenkiisha0126@sjtu.edu.cn	NOUN
ajst-32481	1	38	abstract	abstract	NOUN
ajst-32481	1	39	.	.	PUNCT
ajst-32481	2	1	alzheimer	alzheimer	PROPN
ajst-32481	2	2	’s	’s	PART
ajst-32481	2	3	disease	disease	NOUN
ajst-32481	2	4	(	(	PUNCT
ajst-32481	2	5	ad	ad	NOUN
ajst-32481	2	6	)	)	PUNCT
ajst-32481	2	7	is	be	AUX
ajst-32481	2	8	a	a	DET
ajst-32481	2	9	neurodegenerative	neurodegenerative	ADJ
ajst-32481	2	10	disorder	disorder	NOUN
ajst-32481	2	11	characterized	characterize	VERB
ajst-32481	2	12	by	by	ADP
ajst-32481	2	13	progressive	progressive	ADJ
ajst-32481	2	14	cognitive	cognitive	ADJ
ajst-32481	2	15	impairment	impairment	NOUN
ajst-32481	2	16	,	,	PUNCT
ajst-32481	2	17	with	with	ADP
ajst-32481	2	18	typical	typical	ADJ
ajst-32481	2	19	pathological	pathological	ADJ
ajst-32481	2	20	processes	process	NOUN
ajst-32481	2	21	involving	involve	VERB
ajst-32481	2	22	β	β	NOUN
ajst-32481	2	23	-	-	ADJ
ajst-32481	2	24	amyloid	amyloid	ADJ
ajst-32481	2	25	deposition	deposition	NOUN
ajst-32481	2	26	,	,	PUNCT
ajst-32481	2	27	tau	tau	PROPN
ajst-32481	2	28	hyperphosphorylation	hyperphosphorylation	NOUN
ajst-32481	2	29	,	,	PUNCT
ajst-32481	2	30	neuroinflammation	neuroinflammation	NOUN
ajst-32481	2	31	,	,	PUNCT
ajst-32481	2	32	and	and	CCONJ
ajst-32481	2	33	synaptic	synaptic	ADJ
ajst-32481	2	34	dysfunction	dysfunction	NOUN
ajst-32481	2	35	.	.	PUNCT
ajst-32481	3	1	in	in	ADP
ajst-32481	3	2	recent	recent	ADJ
ajst-32481	3	3	years	year	NOUN
ajst-32481	3	4	,	,	PUNCT
ajst-32481	3	5	the	the	DET
ajst-32481	3	6	gut	gut	NOUN
ajst-32481	3	7	microbiota	microbiota	NOUN
ajst-32481	3	8	,	,	PUNCT
ajst-32481	3	9	residing	reside	VERB
ajst-32481	3	10	in	in	ADP
ajst-32481	3	11	the	the	DET
ajst-32481	3	12	intestine	intestine	NOUN
ajst-32481	3	13	,	,	PUNCT
ajst-32481	3	14	has	have	AUX
ajst-32481	3	15	attracted	attract	VERB
ajst-32481	3	16	increasing	increase	VERB
ajst-32481	3	17	attention	attention	NOUN
ajst-32481	3	18	for	for	ADP
ajst-32481	3	19	its	its	PRON
ajst-32481	3	20	influence	influence	NOUN
ajst-32481	3	21	on	on	ADP
ajst-32481	3	22	ad	ad	NOUN
ajst-32481	3	23	pathology	pathology	NOUN
ajst-32481	3	24	through	through	ADP
ajst-32481	3	25	the	the	DET
ajst-32481	3	26	gut	gut	NOUN
ajst-32481	3	27	-	-	PUNCT
ajst-32481	3	28	brain	brain	NOUN
ajst-32481	3	29	axis	axis	NOUN
ajst-32481	3	30	(	(	PUNCT
ajst-32481	3	31	gba	gba	NOUN
ajst-32481	3	32	)	)	PUNCT
ajst-32481	3	33	.	.	PUNCT
ajst-32481	4	1	studies	study	NOUN
ajst-32481	4	2	have	have	AUX
ajst-32481	4	3	demonstrated	demonstrate	VERB
ajst-32481	4	4	decreased	decrease	VERB
ajst-32481	4	5	gut	gut	NOUN
ajst-32481	4	6	microbial	microbial	ADJ
ajst-32481	4	7	diversity	diversity	NOUN
ajst-32481	4	8	in	in	ADP
ajst-32481	4	9	ad	ad	NOUN
ajst-32481	4	10	patients	patient	NOUN
ajst-32481	4	11	.	.	PUNCT
ajst-32481	5	1	gut	gut	NOUN
ajst-32481	5	2	dysbiosis	dysbiosis	NOUN
ajst-32481	5	3	may	may	AUX
ajst-32481	5	4	contribute	contribute	VERB
ajst-32481	5	5	to	to	ADP
ajst-32481	5	6	ad	ad	NOUN
ajst-32481	5	7	pathogenesis	pathogenesis	NOUN
ajst-32481	5	8	by	by	ADP
ajst-32481	5	9	disrupting	disrupt	VERB
ajst-32481	5	10	the	the	DET
ajst-32481	5	11	bloodbrain	bloodbrain	NOUN
ajst-32481	5	12	barrier	barrier	NOUN
ajst-32481	5	13	,	,	PUNCT
ajst-32481	5	14	activating	activate	VERB
ajst-32481	5	15	microglia	microglia	NOUN
ajst-32481	5	16	,	,	PUNCT
ajst-32481	5	17	exacerbating	exacerbate	VERB
ajst-32481	5	18	neuroinflammation	neuroinflammation	NOUN
ajst-32481	5	19	,	,	PUNCT
ajst-32481	5	20	and	and	CCONJ
ajst-32481	5	21	promoting	promote	VERB
ajst-32481	5	22	aβ	aβ	PRON
ajst-32481	5	23	deposition	deposition	NOUN
ajst-32481	5	24	.	.	PUNCT
ajst-32481	6	1	moreover	moreover	ADV
ajst-32481	6	2	,	,	PUNCT
ajst-32481	6	3	microbial	microbial	ADJ
ajst-32481	6	4	metabolites	metabolite	NOUN
ajst-32481	6	5	and	and	CCONJ
ajst-32481	6	6	microglial	microglial	ADJ
ajst-32481	6	7	activation	activation	NOUN
ajst-32481	6	8	have	have	AUX
ajst-32481	6	9	been	be	AUX
ajst-32481	6	10	identified	identify	VERB
ajst-32481	6	11	as	as	ADP
ajst-32481	6	12	critical	critical	ADJ
ajst-32481	6	13	mediators	mediator	NOUN
ajst-32481	6	14	in	in	ADP
ajst-32481	6	15	ad	ad	NOUN
ajst-32481	6	16	pathology	pathology	NOUN
ajst-32481	6	17	.	.	PUNCT
ajst-32481	7	1	although	although	SCONJ
ajst-32481	7	2	microbiota	microbiota	NOUN
ajst-32481	7	3	-	-	PUNCT
ajst-32481	7	4	targeted	target	VERB
ajst-32481	7	5	strategies	strategy	NOUN
ajst-32481	7	6	such	such	ADJ
ajst-32481	7	7	as	as	ADP
ajst-32481	7	8	probiotics	probiotic	NOUN
ajst-32481	7	9	and	and	CCONJ
ajst-32481	7	10	dietary	dietary	ADJ
ajst-32481	7	11	interventions	intervention	NOUN
ajst-32481	7	12	have	have	AUX
ajst-32481	7	13	shown	show	VERB
ajst-32481	7	14	partial	partial	ADJ
ajst-32481	7	15	therapeutic	therapeutic	ADJ
ajst-32481	7	16	potential	potential	NOUN
ajst-32481	7	17	,	,	PUNCT
ajst-32481	7	18	their	their	PRON
ajst-32481	7	19	clinical	clinical	ADJ
ajst-32481	7	20	efficacy	efficacy	NOUN
ajst-32481	7	21	remains	remain	VERB
ajst-32481	7	22	limited	limit	VERB
ajst-32481	7	23	by	by	ADP
ajst-32481	7	24	individual	individual	ADJ
ajst-32481	7	25	heterogeneity	heterogeneity	NOUN
ajst-32481	7	26	,	,	PUNCT
ajst-32481	7	27	mechanistic	mechanistic	ADJ
ajst-32481	7	28	complexity	complexity	NOUN
ajst-32481	7	29	,	,	PUNCT
ajst-32481	7	30	and	and	CCONJ
ajst-32481	7	31	insufficient	insufficient	ADJ
ajst-32481	7	32	standardization	standardization	NOUN
ajst-32481	7	33	.	.	PUNCT
ajst-32481	8	1	future	future	ADJ
ajst-32481	8	2	research	research	NOUN
ajst-32481	8	3	should	should	AUX
ajst-32481	8	4	integrate	integrate	VERB
ajst-32481	8	5	multi	multi	ADJ
ajst-32481	8	6	-	-	ADJ
ajst-32481	8	7	omics	omics	ADJ
ajst-32481	8	8	technologies	technology	NOUN
ajst-32481	8	9	and	and	CCONJ
ajst-32481	8	10	longitudinal	longitudinal	ADJ
ajst-32481	8	11	cohorts	cohort	NOUN
ajst-32481	8	12	to	to	PART
ajst-32481	8	13	elucidate	elucidate	VERB
ajst-32481	8	14	the	the	DET
ajst-32481	8	15	causal	causal	ADJ
ajst-32481	8	16	mechanisms	mechanism	NOUN
ajst-32481	8	17	of	of	ADP
ajst-32481	8	18	the	the	DET
ajst-32481	8	19	gut	gut	NOUN
ajst-32481	8	20	-	-	PUNCT
ajst-32481	8	21	brain	brain	NOUN
ajst-32481	8	22	axis	axis	NOUN
ajst-32481	8	23	in	in	ADP
ajst-32481	8	24	ad	ad	NOUN
ajst-32481	8	25	progression	progression	NOUN
ajst-32481	8	26	,	,	PUNCT
ajst-32481	8	27	thereby	thereby	ADV
ajst-32481	8	28	facilitating	facilitate	VERB
ajst-32481	8	29	the	the	DET
ajst-32481	8	30	development	development	NOUN
ajst-32481	8	31	of	of	ADP
ajst-32481	8	32	microbiome	microbiome	NOUN
ajst-32481	8	33	-	-	PUNCT
ajst-32481	8	34	based	base	VERB
ajst-32481	8	35	diagnostic	diagnostic	ADJ
ajst-32481	8	36	and	and	CCONJ
ajst-32481	8	37	therapeutic	therapeutic	ADJ
ajst-32481	8	38	strategies	strategy	NOUN
ajst-32481	8	39	.	.	PUNCT
ajst-32481	9	1	keywords	keyword	NOUN
ajst-32481	9	2	:	:	PUNCT
ajst-32481	9	3	alzheimer	alzheimer	PROPN
ajst-32481	9	4	’s	’s	PART
ajst-32481	9	5	disease	disease	NOUN
ajst-32481	9	6	;	;	PUNCT
ajst-32481	9	7	gut	gut	NOUN
ajst-32481	9	8	-	-	PUNCT
ajst-32481	9	9	brain	brain	NOUN
ajst-32481	9	10	axis	axis	NOUN
ajst-32481	9	11	;	;	PUNCT
ajst-32481	9	12	gut	gut	NOUN
ajst-32481	9	13	microbiota	microbiota	NOUN
ajst-32481	9	14	;	;	PUNCT
ajst-32481	9	15	neurodegenerative	neurodegenerative	ADJ
ajst-32481	9	16	disease	disease	NOUN
ajst-32481	9	17	;	;	PUNCT
ajst-32481	9	18	neuroinflammation	neuroinflammation	NOUN
ajst-32481	9	19	.	.	PUNCT
ajst-32481	10	1	1	1	X
ajst-32481	10	2	.	.	X
ajst-32481	10	3	introduction	introduction	NOUN
ajst-32481	10	4	figure	figure	NOUN
ajst-32481	10	5	1	1	NUM
ajst-32481	10	6	.	.	PUNCT
ajst-32481	10	7	mechanisms	mechanism	NOUN
ajst-32481	10	8	of	of	ADP
ajst-32481	10	9	the	the	DET
ajst-32481	10	10	gut	gut	NOUN
ajst-32481	10	11	-	-	PUNCT
ajst-32481	10	12	brain	brain	NOUN
ajst-32481	10	13	axis[4	axis[4	NOUN
ajst-32481	10	14	]	]	PUNCT
ajst-32481	10	15	.	.	PUNCT
ajst-32481	11	1	gut	gut	NOUN
ajst-32481	11	2	microbiota	microbiota	NOUN
ajst-32481	11	3	can	can	AUX
ajst-32481	11	4	influence	influence	VERB
ajst-32481	11	5	brain	brain	NOUN
ajst-32481	11	6	activity	activity	NOUN
ajst-32481	11	7	through	through	ADP
ajst-32481	11	8	multiple	multiple	ADJ
ajst-32481	11	9	pathways	pathway	NOUN
ajst-32481	11	10	alzheimer	alzheimer	PROPN
ajst-32481	11	11	’s	’s	PART
ajst-32481	11	12	disease	disease	NOUN
ajst-32481	11	13	(	(	PUNCT
ajst-32481	11	14	ad	ad	NOUN
ajst-32481	11	15	)	)	PUNCT
ajst-32481	11	16	is	be	AUX
ajst-32481	11	17	a	a	DET
ajst-32481	11	18	neurodegenerative	neurodegenerative	ADJ
ajst-32481	11	19	disorder	disorder	NOUN
ajst-32481	11	20	with	with	ADP
ajst-32481	11	21	pathological	pathological	ADJ
ajst-32481	11	22	hallmarks	hallmark	NOUN
ajst-32481	11	23	of	of	ADP
ajst-32481	11	24	progressive	progressive	ADJ
ajst-32481	11	25	cognitive	cognitive	ADJ
ajst-32481	11	26	impairment	impairment	NOUN
ajst-32481	11	27	.	.	PUNCT
ajst-32481	12	1	its	its	PRON
ajst-32481	12	2	main	main	ADJ
ajst-32481	12	3	clinical	clinical	ADJ
ajst-32481	12	4	symptoms	symptom	NOUN
ajst-32481	12	5	include	include	VERB
ajst-32481	12	6	memory	memory	NOUN
ajst-32481	12	7	decline	decline	NOUN
ajst-32481	12	8	,	,	PUNCT
ajst-32481	12	9	behavioral	behavioral	ADJ
ajst-32481	12	10	changes	change	NOUN
ajst-32481	12	11	,	,	PUNCT
ajst-32481	12	12	and	and	CCONJ
ajst-32481	12	13	gradual	gradual	ADJ
ajst-32481	12	14	loss	loss	NOUN
ajst-32481	12	15	of	of	ADP
ajst-32481	12	16	daily	daily	ADJ
ajst-32481	12	17	living	living	NOUN
ajst-32481	12	18	abilities	ability	NOUN
ajst-32481	12	19	.	.	PUNCT
ajst-32481	13	1	with	with	ADP
ajst-32481	13	2	the	the	DET
ajst-32481	13	3	global	global	ADJ
ajst-32481	13	4	trend	trend	NOUN
ajst-32481	13	5	of	of	ADP
ajst-32481	13	6	population	population	NOUN
ajst-32481	13	7	aging	aging	NOUN
ajst-32481	13	8	,	,	PUNCT
ajst-32481	13	9	the	the	DET
ajst-32481	13	10	incidence	incidence	NOUN
ajst-32481	13	11	of	of	ADP
ajst-32481	13	12	ad	ad	NOUN
ajst-32481	13	13	is	be	AUX
ajst-32481	13	14	rising	rise	VERB
ajst-32481	13	15	annually	annually	ADV
ajst-32481	13	16	.	.	PUNCT
ajst-32481	14	1	by	by	ADP
ajst-32481	14	2	2030	2030	NUM
ajst-32481	14	3	,	,	PUNCT
ajst-32481	14	4	the	the	DET
ajst-32481	14	5	number	number	NOUN
ajst-32481	14	6	of	of	ADP
ajst-32481	14	7	dementia	dementia	NOUN
ajst-32481	14	8	patients	patient	NOUN
ajst-32481	14	9	worldwide	worldwide	ADV
ajst-32481	14	10	is	be	AUX
ajst-32481	14	11	projected	project	VERB
ajst-32481	14	12	to	to	PART
ajst-32481	14	13	reach	reach	VERB
ajst-32481	14	14	78	78	NUM
ajst-32481	14	15	million	million	NUM
ajst-32481	15	1	[	[	X
ajst-32481	15	2	1	1	NUM
ajst-32481	15	3	]	]	PUNCT
ajst-32481	15	4	,	,	PUNCT
ajst-32481	15	5	posing	pose	VERB
ajst-32481	15	6	challenges	challenge	NOUN
ajst-32481	15	7	to	to	ADP
ajst-32481	15	8	healthcare	healthcare	NOUN
ajst-32481	15	9	systems	system	NOUN
ajst-32481	15	10	and	and	CCONJ
ajst-32481	15	11	society	society	NOUN
ajst-32481	15	12	at	at	ADP
ajst-32481	15	13	large	large	ADJ
ajst-32481	15	14	across	across	ADP
ajst-32481	15	15	economic	economic	ADJ
ajst-32481	15	16	,	,	PUNCT
ajst-32481	15	17	ethical	ethical	ADJ
ajst-32481	15	18	,	,	PUNCT
ajst-32481	15	19	policy	policy	NOUN
ajst-32481	15	20	,	,	PUNCT
ajst-32481	15	21	and	and	CCONJ
ajst-32481	15	22	cultural	cultural	ADJ
ajst-32481	15	23	dimensions	dimension	NOUN
ajst-32481	15	24	.	.	PUNCT
ajst-32481	16	1	the	the	DET
ajst-32481	16	2	classical	classical	ADJ
ajst-32481	16	3	pathological	pathological	ADJ
ajst-32481	16	4	features	feature	NOUN
ajst-32481	16	5	of	of	ADP
ajst-32481	16	6	ad	ad	NOUN
ajst-32481	16	7	involve	involve	VERB
ajst-32481	16	8	aβ	aβ	ADP
ajst-32481	16	9	deposition	deposition	NOUN
ajst-32481	16	10	,	,	PUNCT
ajst-32481	16	11	tau	tau	PROPN
ajst-32481	16	12	hyperphosphorylation	hyperphosphorylation	NOUN
ajst-32481	16	13	,	,	PUNCT
ajst-32481	16	14	neuroinflammation	neuroinflammation	NOUN
ajst-32481	16	15	,	,	PUNCT
ajst-32481	16	16	and	and	CCONJ
ajst-32481	16	17	synaptic	synaptic	ADJ
ajst-32481	16	18	dysfunction[2	dysfunction[2	NOUN
ajst-32481	16	19	]	]	PUNCT
ajst-32481	16	20	,	,	PUNCT
ajst-32481	16	21	reflecting	reflect	VERB
ajst-32481	16	22	its	its	PRON
ajst-32481	16	23	high	high	ADJ
ajst-32481	16	24	complexity	complexity	NOUN
ajst-32481	16	25	.	.	PUNCT
ajst-32481	17	1	in	in	ADP
ajst-32481	17	2	recent	recent	ADJ
ajst-32481	17	3	years	year	NOUN
ajst-32481	17	4	,	,	PUNCT
ajst-32481	17	5	the	the	DET
ajst-32481	17	6	gut	gut	NOUN
ajst-32481	17	7	-	-	PUNCT
ajst-32481	17	8	brain	brain	NOUN
ajst-32481	17	9	axis	axis	NOUN
ajst-32481	17	10	has	have	AUX
ajst-32481	17	11	emerged	emerge	VERB
ajst-32481	17	12	as	as	ADP
ajst-32481	17	13	a	a	DET
ajst-32481	17	14	research	research	NOUN
ajst-32481	17	15	frontier	frontier	NOUN
ajst-32481	17	16	in	in	ADP
ajst-32481	17	17	99	99	NUM
ajst-32481	17	18	neurodegenerative	neurodegenerative	ADJ
ajst-32481	17	19	diseases	disease	NOUN
ajst-32481	17	20	.	.	PUNCT
ajst-32481	18	1	dysbiosis	dysbiosis	NOUN
ajst-32481	18	2	of	of	ADP
ajst-32481	18	3	the	the	DET
ajst-32481	18	4	gut	gut	NOUN
ajst-32481	18	5	microbiota	microbiota	NOUN
ajst-32481	18	6	may	may	AUX
ajst-32481	18	7	participate	participate	VERB
ajst-32481	18	8	in	in	ADP
ajst-32481	18	9	ad	ad	NOUN
ajst-32481	18	10	pathogenesis	pathogenesis	NOUN
ajst-32481	18	11	by	by	ADP
ajst-32481	18	12	modulating	modulate	VERB
ajst-32481	18	13	microglia	microglia	NOUN
ajst-32481	18	14	,	,	PUNCT
ajst-32481	18	15	activating	activate	VERB
ajst-32481	18	16	inflammatory	inflammatory	ADJ
ajst-32481	18	17	factors	factor	NOUN
ajst-32481	18	18	,	,	PUNCT
ajst-32481	18	19	impairing	impair	VERB
ajst-32481	18	20	aβ	aβ	ADP
ajst-32481	18	21	clearance	clearance	NOUN
ajst-32481	18	22	,	,	PUNCT
ajst-32481	18	23	and	and	CCONJ
ajst-32481	18	24	increasing	increase	VERB
ajst-32481	18	25	blood	blood	NOUN
ajst-32481	18	26	-	-	PUNCT
ajst-32481	18	27	brain	brain	NOUN
ajst-32481	18	28	barrier	barrier	NOUN
ajst-32481	18	29	permeability[3	permeability[3	VERB
ajst-32481	18	30	]	]	PUNCT
ajst-32481	18	31	.	.	PUNCT
ajst-32481	19	1	although	although	SCONJ
ajst-32481	19	2	numerous	numerous	ADJ
ajst-32481	19	3	studies	study	NOUN
ajst-32481	19	4	have	have	AUX
ajst-32481	19	5	revealed	reveal	VERB
ajst-32481	19	6	potential	potential	ADJ
ajst-32481	19	7	associations	association	NOUN
ajst-32481	19	8	between	between	ADP
ajst-32481	19	9	gut	gut	NOUN
ajst-32481	19	10	microbiota	microbiota	NOUN
ajst-32481	19	11	and	and	CCONJ
ajst-32481	19	12	ad	ad	NOUN
ajst-32481	19	13	,	,	PUNCT
ajst-32481	19	14	the	the	DET
ajst-32481	19	15	precise	precise	ADJ
ajst-32481	19	16	mechanisms	mechanism	NOUN
ajst-32481	19	17	and	and	CCONJ
ajst-32481	19	18	microbiome	microbiome	NOUN
ajst-32481	19	19	-	-	PUNCT
ajst-32481	19	20	based	base	VERB
ajst-32481	19	21	therapeutic	therapeutic	ADJ
ajst-32481	19	22	strategies	strategy	NOUN
ajst-32481	19	23	remain	remain	VERB
ajst-32481	19	24	to	to	PART
ajst-32481	19	25	be	be	AUX
ajst-32481	19	26	fully	fully	ADV
ajst-32481	19	27	elucidated	elucidated	ADJ
ajst-32481	19	28	.	.	PUNCT
ajst-32481	20	1	the	the	DET
ajst-32481	20	2	potential	potential	ADJ
ajst-32481	20	3	association	association	NOUN
ajst-32481	20	4	between	between	ADP
ajst-32481	20	5	the	the	DET
ajst-32481	20	6	gut	gut	NOUN
ajst-32481	20	7	microbiome	microbiome	NOUN
ajst-32481	20	8	and	and	CCONJ
ajst-32481	20	9	the	the	DET
ajst-32481	20	10	nervous	nervous	ADJ
ajst-32481	20	11	system	system	NOUN
ajst-32481	20	12	not	not	PART
ajst-32481	20	13	only	only	ADV
ajst-32481	20	14	provides	provide	VERB
ajst-32481	20	15	a	a	DET
ajst-32481	20	16	novel	novel	ADJ
ajst-32481	20	17	theoretical	theoretical	ADJ
ajst-32481	20	18	perspective	perspective	NOUN
ajst-32481	20	19	on	on	ADP
ajst-32481	20	20	the	the	DET
ajst-32481	20	21	pathogenesis	pathogenesis	NOUN
ajst-32481	20	22	of	of	ADP
ajst-32481	20	23	alzheimer	alzheimer	PROPN
ajst-32481	20	24	’s	’s	PART
ajst-32481	20	25	disease	disease	NOUN
ajst-32481	20	26	(	(	PUNCT
ajst-32481	20	27	ad	ad	NOUN
ajst-32481	20	28	)	)	PUNCT
ajst-32481	20	29	,	,	PUNCT
ajst-32481	20	30	but	but	CCONJ
ajst-32481	20	31	also	also	ADV
ajst-32481	20	32	opens	open	VERB
ajst-32481	20	33	up	up	ADP
ajst-32481	20	34	new	new	ADJ
ajst-32481	20	35	avenues	avenue	NOUN
ajst-32481	20	36	for	for	ADP
ajst-32481	20	37	its	its	PRON
ajst-32481	20	38	prevention	prevention	NOUN
ajst-32481	20	39	and	and	CCONJ
ajst-32481	20	40	treatment	treatment	NOUN
ajst-32481	20	41	.	.	PUNCT
ajst-32481	21	1	research	research	NOUN
ajst-32481	21	2	on	on	ADP
ajst-32481	21	3	interventions	intervention	NOUN
ajst-32481	21	4	based	base	VERB
ajst-32481	21	5	on	on	ADP
ajst-32481	21	6	constructing	construct	VERB
ajst-32481	21	7	a	a	DET
ajst-32481	21	8	bidirectional	bidirectional	ADJ
ajst-32481	21	9	gut	gut	NOUN
ajst-32481	21	10	–	–	PUNCT
ajst-32481	21	11	brain	brain	NOUN
ajst-32481	21	12	axis	axis	ADJ
ajst-32481	21	13	regulatory	regulatory	ADJ
ajst-32481	21	14	system	system	NOUN
ajst-32481	21	15	may	may	AUX
ajst-32481	21	16	not	not	PART
ajst-32481	21	17	only	only	ADV
ajst-32481	21	18	improve	improve	VERB
ajst-32481	21	19	the	the	DET
ajst-32481	21	20	cognitive	cognitive	ADJ
ajst-32481	21	21	function	function	NOUN
ajst-32481	21	22	and	and	CCONJ
ajst-32481	21	23	quality	quality	NOUN
ajst-32481	21	24	of	of	ADP
ajst-32481	21	25	life	life	NOUN
ajst-32481	21	26	of	of	ADP
ajst-32481	21	27	ad	ad	NOUN
ajst-32481	21	28	patients[5	patients[5	PROPN
ajst-32481	21	29	]	]	PUNCT
ajst-32481	21	30	,	,	PUNCT
ajst-32481	21	31	but	but	CCONJ
ajst-32481	21	32	also	also	ADV
ajst-32481	21	33	offer	offer	VERB
ajst-32481	21	34	potential	potential	ADJ
ajst-32481	21	35	targets	target	NOUN
ajst-32481	21	36	for	for	ADP
ajst-32481	21	37	future	future	ADJ
ajst-32481	21	38	personalized	personalize	VERB
ajst-32481	21	39	and	and	CCONJ
ajst-32481	21	40	precision	precision	NOUN
ajst-32481	21	41	therapies	therapy	NOUN
ajst-32481	21	42	for	for	ADP
ajst-32481	21	43	ad	ad	NOUN
ajst-32481	21	44	,	,	PUNCT
ajst-32481	21	45	carrying	carry	VERB
ajst-32481	21	46	significant	significant	ADJ
ajst-32481	21	47	clinical	clinical	ADJ
ajst-32481	21	48	value[6	value[6	NOUN
ajst-32481	21	49	]	]	PUNCT
ajst-32481	21	50	.	.	PUNCT
ajst-32481	22	1	this	this	DET
ajst-32481	22	2	paper	paper	NOUN
ajst-32481	22	3	will	will	AUX
ajst-32481	22	4	first	first	ADV
ajst-32481	22	5	introduce	introduce	VERB
ajst-32481	22	6	the	the	DET
ajst-32481	22	7	basic	basic	ADJ
ajst-32481	22	8	concepts	concept	NOUN
ajst-32481	22	9	of	of	ADP
ajst-32481	22	10	the	the	DET
ajst-32481	22	11	microbiota	microbiota	NOUN
ajst-32481	22	12	-	-	PUNCT
ajst-32481	22	13	gut	gut	NOUN
ajst-32481	22	14	-	-	PUNCT
ajst-32481	22	15	brain	brain	NOUN
ajst-32481	22	16	axis	axis	NOUN
ajst-32481	22	17	,	,	PUNCT
ajst-32481	22	18	then	then	ADV
ajst-32481	22	19	discuss	discuss	VERB
ajst-32481	22	20	the	the	DET
ajst-32481	22	21	role	role	NOUN
ajst-32481	22	22	of	of	ADP
ajst-32481	22	23	the	the	DET
ajst-32481	22	24	gut	gut	NOUN
ajst-32481	22	25	microbiome	microbiome	NOUN
ajst-32481	22	26	in	in	ADP
ajst-32481	22	27	ad	ad	NOUN
ajst-32481	22	28	pathology	pathology	NOUN
ajst-32481	22	29	,	,	PUNCT
ajst-32481	22	30	including	include	VERB
ajst-32481	22	31	its	its	PRON
ajst-32481	22	32	impact	impact	NOUN
ajst-32481	22	33	on	on	ADP
ajst-32481	22	34	neuroinflammation	neuroinflammation	NOUN
ajst-32481	22	35	,	,	PUNCT
ajst-32481	22	36	aβ	aβ	ADP
ajst-32481	22	37	deposition	deposition	NOUN
ajst-32481	22	38	,	,	PUNCT
ajst-32481	22	39	and	and	CCONJ
ajst-32481	22	40	the	the	DET
ajst-32481	22	41	blood	blood	NOUN
ajst-32481	22	42	-	-	PUNCT
ajst-32481	22	43	brain	brain	NOUN
ajst-32481	22	44	barrier	barrier	NOUN
ajst-32481	22	45	.	.	PUNCT
ajst-32481	23	1	subsequently	subsequently	ADV
ajst-32481	23	2	,	,	PUNCT
ajst-32481	23	3	current	current	ADJ
ajst-32481	23	4	interventions	intervention	NOUN
ajst-32481	23	5	such	such	ADJ
ajst-32481	23	6	as	as	ADP
ajst-32481	23	7	dietary	dietary	ADJ
ajst-32481	23	8	modification	modification	NOUN
ajst-32481	23	9	,	,	PUNCT
ajst-32481	23	10	probiotics	probiotic	NOUN
ajst-32481	23	11	,	,	PUNCT
ajst-32481	23	12	and	and	CCONJ
ajst-32481	23	13	fecal	fecal	ADJ
ajst-32481	23	14	microbiota	microbiota	NOUN
ajst-32481	23	15	transplantation	transplantation	NOUN
ajst-32481	23	16	will	will	AUX
ajst-32481	23	17	be	be	AUX
ajst-32481	23	18	summarized	summarize	VERB
ajst-32481	23	19	,	,	PUNCT
ajst-32481	23	20	with	with	ADP
ajst-32481	23	21	an	an	DET
ajst-32481	23	22	evaluation	evaluation	NOUN
ajst-32481	23	23	of	of	ADP
ajst-32481	23	24	their	their	PRON
ajst-32481	23	25	clinical	clinical	ADJ
ajst-32481	23	26	efficacy	efficacy	NOUN
ajst-32481	23	27	[	[	X
ajst-32481	23	28	7	7	NUM
ajst-32481	23	29	]	]	PUNCT
ajst-32481	23	30	.	.	PUNCT
ajst-32481	24	1	finally	finally	ADV
ajst-32481	24	2	,	,	PUNCT
ajst-32481	24	3	the	the	DET
ajst-32481	24	4	review	review	NOUN
ajst-32481	24	5	will	will	AUX
ajst-32481	24	6	highlight	highlight	VERB
ajst-32481	24	7	future	future	ADJ
ajst-32481	24	8	research	research	NOUN
ajst-32481	24	9	directions	direction	NOUN
ajst-32481	24	10	and	and	CCONJ
ajst-32481	24	11	potential	potential	ADJ
ajst-32481	24	12	therapeutic	therapeutic	ADJ
ajst-32481	24	13	targets	target	NOUN
ajst-32481	24	14	,	,	PUNCT
ajst-32481	24	15	offering	offer	VERB
ajst-32481	24	16	new	new	ADJ
ajst-32481	24	17	perspectives	perspective	NOUN
ajst-32481	24	18	for	for	ADP
ajst-32481	24	19	ad	ad	NOUN
ajst-32481	24	20	treatment	treatment	NOUN
ajst-32481	24	21	and	and	CCONJ
ajst-32481	24	22	intervention	intervention	NOUN
ajst-32481	24	23	.	.	PUNCT
ajst-32481	25	1	2	2	X
ajst-32481	25	2	.	.	X
ajst-32481	25	3	gut	gut	VERB
ajst-32481	25	4	microbiota	microbiota	NOUN
ajst-32481	25	5	2.1	2.1	NUM
ajst-32481	25	6	diversity	diversity	NOUN
ajst-32481	25	7	of	of	ADP
ajst-32481	25	8	the	the	DET
ajst-32481	25	9	gut	gut	NOUN
ajst-32481	25	10	microbiome	microbiome	NOUN
ajst-32481	25	11	the	the	DET
ajst-32481	25	12	gut	gut	NOUN
ajst-32481	25	13	microbiota	microbiota	NOUN
ajst-32481	25	14	is	be	AUX
ajst-32481	25	15	a	a	DET
ajst-32481	25	16	complex	complex	ADJ
ajst-32481	25	17	ecosystem	ecosystem	NOUN
ajst-32481	25	18	colonizing	colonize	VERB
ajst-32481	25	19	the	the	DET
ajst-32481	25	20	intestine	intestine	NOUN
ajst-32481	25	21	,	,	PUNCT
ajst-32481	25	22	comprising	comprise	VERB
ajst-32481	25	23	beneficial	beneficial	ADJ
ajst-32481	25	24	,	,	PUNCT
ajst-32481	25	25	harmful	harmful	ADJ
ajst-32481	25	26	,	,	PUNCT
ajst-32481	25	27	and	and	CCONJ
ajst-32481	25	28	neutral	neutral	ADJ
ajst-32481	25	29	microbes	microbe	NOUN
ajst-32481	25	30	.	.	PUNCT
ajst-32481	26	1	more	more	ADJ
ajst-32481	26	2	than	than	ADP
ajst-32481	26	3	1,000	1,000	NUM
ajst-32481	26	4	microbial	microbial	ADJ
ajst-32481	26	5	species	specie	NOUN
ajst-32481	26	6	inhabit	inhabit	VERB
ajst-32481	26	7	the	the	DET
ajst-32481	26	8	adult	adult	NOUN
ajst-32481	26	9	human	human	ADJ
ajst-32481	26	10	gut	gut	NOUN
ajst-32481	26	11	,	,	PUNCT
ajst-32481	26	12	with	with	ADP
ajst-32481	26	13	an	an	DET
ajst-32481	26	14	estimated	estimate	VERB
ajst-32481	26	15	total	total	NOUN
ajst-32481	26	16	of	of	ADP
ajst-32481	26	17	up	up	ADP
ajst-32481	26	18	to	to	PART
ajst-32481	26	19	1014	1014	NUM
ajst-32481	26	20	cells	cell	NOUN
ajst-32481	26	21	[	[	X
ajst-32481	26	22	8	8	NUM
ajst-32481	26	23	]	]	PUNCT
ajst-32481	26	24	,	,	PUNCT
ajst-32481	26	25	weighing	weigh	VERB
ajst-32481	26	26	approximately	approximately	ADV
ajst-32481	26	27	1.2	1.2	NUM
ajst-32481	26	28	kg	kg	NOUN
ajst-32481	26	29	,	,	PUNCT
ajst-32481	26	30	and	and	CCONJ
ajst-32481	26	31	containing	contain	VERB
ajst-32481	26	32	a	a	DET
ajst-32481	26	33	gene	gene	NOUN
ajst-32481	26	34	pool	pool	NOUN
ajst-32481	26	35	about	about	ADV
ajst-32481	26	36	150	150	NUM
ajst-32481	26	37	times	time	NOUN
ajst-32481	26	38	larger	large	ADJ
ajst-32481	26	39	than	than	ADP
ajst-32481	26	40	the	the	DET
ajst-32481	26	41	human	human	ADJ
ajst-32481	26	42	genome	genome	NOUN
ajst-32481	26	43	.	.	PUNCT
ajst-32481	27	1	these	these	DET
ajst-32481	27	2	microbes	microbe	NOUN
ajst-32481	27	3	are	be	AUX
ajst-32481	27	4	involved	involve	VERB
ajst-32481	27	5	in	in	ADP
ajst-32481	27	6	numerous	numerous	ADJ
ajst-32481	27	7	physiological	physiological	ADJ
ajst-32481	27	8	and	and	CCONJ
ajst-32481	27	9	biochemical	biochemical	ADJ
ajst-32481	27	10	processes	process	NOUN
ajst-32481	27	11	.	.	PUNCT
ajst-32481	28	1	for	for	ADP
ajst-32481	28	2	instance	instance	NOUN
ajst-32481	28	3	,	,	PUNCT
ajst-32481	28	4	beneficial	beneficial	ADJ
ajst-32481	28	5	bacteria	bacteria	NOUN
ajst-32481	28	6	such	such	ADJ
ajst-32481	28	7	as	as	ADP
ajst-32481	28	8	lactobacillus	lactobacillus	NOUN
ajst-32481	28	9	can	can	AUX
ajst-32481	28	10	facilitate	facilitate	VERB
ajst-32481	28	11	digestion	digestion	NOUN
ajst-32481	28	12	,	,	PUNCT
ajst-32481	28	13	synthesize	synthesize	VERB
ajst-32481	28	14	vitamins	vitamin	NOUN
ajst-32481	28	15	,	,	PUNCT
ajst-32481	28	16	regulate	regulate	VERB
ajst-32481	28	17	immune	immune	ADJ
ajst-32481	28	18	function	function	NOUN
ajst-32481	28	19	,	,	PUNCT
ajst-32481	28	20	and	and	CCONJ
ajst-32481	28	21	inhibit	inhibit	VERB
ajst-32481	28	22	the	the	DET
ajst-32481	28	23	growth	growth	NOUN
ajst-32481	28	24	of	of	ADP
ajst-32481	28	25	pathogenic	pathogenic	ADJ
ajst-32481	28	26	bacteria	bacteria	NOUN
ajst-32481	28	27	.	.	PUNCT
ajst-32481	29	1	by	by	ADP
ajst-32481	29	2	contrast	contrast	NOUN
ajst-32481	29	3	,	,	PUNCT
ajst-32481	29	4	harmful	harmful	ADJ
ajst-32481	29	5	bacteria	bacteria	NOUN
ajst-32481	29	6	such	such	ADJ
ajst-32481	29	7	as	as	ADP
ajst-32481	29	8	clostridium	clostridium	NOUN
ajst-32481	29	9	difficile	difficile	NOUN
ajst-32481	29	10	may	may	AUX
ajst-32481	29	11	trigger	trigger	VERB
ajst-32481	29	12	intestinal	intestinal	ADJ
ajst-32481	29	13	infections	infection	NOUN
ajst-32481	29	14	and	and	CCONJ
ajst-32481	29	15	inflammation	inflammation	NOUN
ajst-32481	29	16	.	.	PUNCT
ajst-32481	30	1	collectively	collectively	ADV
ajst-32481	30	2	,	,	PUNCT
ajst-32481	30	3	these	these	DET
ajst-32481	30	4	findings	finding	NOUN
ajst-32481	30	5	underscore	underscore	VERB
ajst-32481	30	6	the	the	DET
ajst-32481	30	7	essential	essential	ADJ
ajst-32481	30	8	role	role	NOUN
ajst-32481	30	9	of	of	ADP
ajst-32481	30	10	the	the	DET
ajst-32481	30	11	gut	gut	NOUN
ajst-32481	30	12	microbiome	microbiome	NOUN
ajst-32481	30	13	in	in	ADP
ajst-32481	30	14	human	human	ADJ
ajst-32481	30	15	health	health	NOUN
ajst-32481	30	16	.	.	PUNCT
ajst-32481	31	1	figure	figure	NOUN
ajst-32481	31	2	2	2	NUM
ajst-32481	31	3	.	.	PUNCT
ajst-32481	31	4	simplified	simplify	VERB
ajst-32481	31	5	classification	classification	NOUN
ajst-32481	31	6	of	of	ADP
ajst-32481	31	7	gut	gut	NOUN
ajst-32481	31	8	microbes	microbe	NOUN
ajst-32481	31	9	.	.	PUNCT
ajst-32481	32	1	the	the	DET
ajst-32481	32	2	human	human	ADJ
ajst-32481	32	3	intestinal	intestinal	ADJ
ajst-32481	32	4	environment	environment	NOUN
ajst-32481	32	5	harbors	harbor	VERB
ajst-32481	32	6	diverse	diverse	ADJ
ajst-32481	32	7	microbial	microbial	ADJ
ajst-32481	32	8	species	specie	NOUN
ajst-32481	32	9	,	,	PUNCT
ajst-32481	32	10	including	include	VERB
ajst-32481	32	11	both	both	CCONJ
ajst-32481	32	12	beneficial	beneficial	ADJ
ajst-32481	32	13	and	and	CCONJ
ajst-32481	32	14	harmful	harmful	ADJ
ajst-32481	32	15	bacteria	bacteria	NOUN
ajst-32481	32	16	.	.	PUNCT
ajst-32481	33	1	2.2	2.2	NUM
ajst-32481	33	2	how	how	SCONJ
ajst-32481	33	3	the	the	DET
ajst-32481	33	4	gut	gut	NOUN
ajst-32481	33	5	microbiome	microbiome	NOUN
ajst-32481	33	6	participates	participate	VERB
ajst-32481	33	7	in	in	ADP
ajst-32481	33	8	life	life	NOUN
ajst-32481	33	9	processes	process	NOUN
ajst-32481	33	10	due	due	ADJ
ajst-32481	33	11	to	to	ADP
ajst-32481	33	12	its	its	PRON
ajst-32481	33	13	remarkable	remarkable	ADJ
ajst-32481	33	14	diversity	diversity	NOUN
ajst-32481	33	15	,	,	PUNCT
ajst-32481	33	16	the	the	DET
ajst-32481	33	17	gut	gut	NOUN
ajst-32481	33	18	microbiome	microbiome	NOUN
ajst-32481	33	19	regulates	regulate	VERB
ajst-32481	33	20	multiple	multiple	ADJ
ajst-32481	33	21	physiological	physiological	ADJ
ajst-32481	33	22	functions	function	NOUN
ajst-32481	33	23	of	of	ADP
ajst-32481	33	24	the	the	DET
ajst-32481	33	25	host	host	NOUN
ajst-32481	33	26	via	via	ADP
ajst-32481	33	27	microbial	microbial	ADJ
ajst-32481	33	28	metabolites	metabolite	NOUN
ajst-32481	33	29	,	,	PUNCT
ajst-32481	33	30	immune	immune	ADJ
ajst-32481	33	31	modulation	modulation	NOUN
ajst-32481	33	32	,	,	PUNCT
ajst-32481	33	33	and	and	CCONJ
ajst-32481	33	34	signal	signal	VERB
ajst-32481	33	35	transduction	transduction	NOUN
ajst-32481	33	36	with	with	ADP
ajst-32481	33	37	the	the	DET
ajst-32481	33	38	nervous	nervous	ADJ
ajst-32481	33	39	system	system	NOUN
ajst-32481	33	40	.	.	PUNCT
ajst-32481	34	1	for	for	ADP
ajst-32481	34	2	example	example	NOUN
ajst-32481	34	3	,	,	PUNCT
ajst-32481	34	4	in	in	ADP
ajst-32481	34	5	immune	immune	ADJ
ajst-32481	34	6	regulation	regulation	NOUN
ajst-32481	34	7	,	,	PUNCT
ajst-32481	34	8	short	short	ADJ
ajst-32481	34	9	-	-	PUNCT
ajst-32481	34	10	chain	chain	NOUN
ajst-32481	34	11	fatty	fatty	NOUN
ajst-32481	34	12	acids	acid	NOUN
ajst-32481	34	13	(	(	PUNCT
ajst-32481	34	14	scfas	scfas	NOUN
ajst-32481	34	15	)	)	PUNCT
ajst-32481	34	16	such	such	ADJ
ajst-32481	34	17	as	as	ADP
ajst-32481	34	18	butyrate	butyrate	NOUN
ajst-32481	34	19	can	can	AUX
ajst-32481	34	20	induce	induce	VERB
ajst-32481	34	21	bone	bone	NOUN
ajst-32481	34	22	marrow	marrow	NOUN
ajst-32481	34	23	monocytes	monocyte	VERB
ajst-32481	34	24	to	to	PART
ajst-32481	34	25	differentiate	differentiate	VERB
ajst-32481	34	26	into	into	ADP
ajst-32481	34	27	a	a	DET
ajst-32481	34	28	tolerogenic	tolerogenic	ADJ
ajst-32481	34	29	phenotype	phenotype	NOUN
ajst-32481	35	1	[	[	X
ajst-32481	35	2	9	9	NUM
ajst-32481	35	3	]	]	PUNCT
ajst-32481	35	4	.	.	PUNCT
ajst-32481	36	1	the	the	DET
ajst-32481	36	2	gut	gut	NOUN
ajst-32481	36	3	microbiota	microbiota	NOUN
ajst-32481	36	4	can	can	AUX
ajst-32481	36	5	also	also	ADV
ajst-32481	36	6	influence	influence	VERB
ajst-32481	36	7	the	the	DET
ajst-32481	36	8	differentiation	differentiation	NOUN
ajst-32481	36	9	of	of	ADP
ajst-32481	36	10	hematopoietic	hematopoietic	ADJ
ajst-32481	36	11	stem	stem	NOUN
ajst-32481	36	12	and	and	CCONJ
ajst-32481	36	13	progenitor	progenitor	NOUN
ajst-32481	36	14	cells	cell	NOUN
ajst-32481	36	15	(	(	PUNCT
ajst-32481	36	16	hspcs	hspc	NOUN
ajst-32481	36	17	)	)	PUNCT
ajst-32481	36	18	,	,	PUNCT
ajst-32481	36	19	thereby	thereby	ADV
ajst-32481	36	20	100	100	NUM
ajst-32481	36	21	shaping	shape	VERB
ajst-32481	36	22	the	the	DET
ajst-32481	36	23	production	production	NOUN
ajst-32481	36	24	of	of	ADP
ajst-32481	36	25	immune	immune	ADJ
ajst-32481	36	26	cells[10	cells[10	NOUN
ajst-32481	36	27	]	]	PUNCT
ajst-32481	36	28	.	.	PUNCT
ajst-32481	37	1	in	in	ADP
ajst-32481	37	2	addition	addition	NOUN
ajst-32481	37	3	,	,	PUNCT
ajst-32481	37	4	pattern	pattern	NOUN
ajst-32481	37	5	recognition	recognition	NOUN
ajst-32481	37	6	receptors	receptor	NOUN
ajst-32481	37	7	(	(	PUNCT
ajst-32481	37	8	prrs	prr	NOUN
ajst-32481	37	9	)	)	PUNCT
ajst-32481	37	10	on	on	ADP
ajst-32481	37	11	intestinal	intestinal	ADJ
ajst-32481	37	12	epithelial	epithelial	ADJ
ajst-32481	37	13	cells	cell	NOUN
ajst-32481	37	14	can	can	AUX
ajst-32481	37	15	recognize	recognize	VERB
ajst-32481	37	16	microbe	microbe	NOUN
ajst-32481	37	17	-	-	PUNCT
ajst-32481	37	18	associated	associate	VERB
ajst-32481	37	19	molecular	molecular	ADJ
ajst-32481	37	20	patterns	pattern	NOUN
ajst-32481	37	21	(	(	PUNCT
ajst-32481	37	22	mamps	mamp	NOUN
ajst-32481	37	23	)	)	PUNCT
ajst-32481	37	24	from	from	ADP
ajst-32481	37	25	the	the	DET
ajst-32481	37	26	microbiota	microbiota	NOUN
ajst-32481	37	27	,	,	PUNCT
ajst-32481	37	28	triggering	trigger	VERB
ajst-32481	37	29	immune	immune	ADJ
ajst-32481	37	30	responses[10	responses[10	NOUN
ajst-32481	37	31	]	]	PUNCT
ajst-32481	37	32	.	.	PUNCT
ajst-32481	38	1	for	for	ADP
ajst-32481	38	2	instance	instance	NOUN
ajst-32481	38	3	,	,	PUNCT
ajst-32481	38	4	toll	toll	NOUN
ajst-32481	38	5	-	-	PUNCT
ajst-32481	38	6	like	like	ADJ
ajst-32481	38	7	receptors	receptor	NOUN
ajst-32481	38	8	(	(	PUNCT
ajst-32481	38	9	tlrs	tlrs	NOUN
ajst-32481	38	10	)	)	PUNCT
ajst-32481	38	11	,	,	PUNCT
ajst-32481	38	12	a	a	DET
ajst-32481	38	13	type	type	NOUN
ajst-32481	38	14	of	of	ADP
ajst-32481	38	15	prr	prr	NOUN
ajst-32481	38	16	,	,	PUNCT
ajst-32481	38	17	can	can	AUX
ajst-32481	38	18	induce	induce	VERB
ajst-32481	38	19	chemokine	chemokine	ADJ
ajst-32481	38	20	and	and	CCONJ
ajst-32481	38	21	cytokine	cytokine	VERB
ajst-32481	38	22	production	production	NOUN
ajst-32481	38	23	upon	upon	SCONJ
ajst-32481	38	24	activation	activation	NOUN
ajst-32481	38	25	,	,	PUNCT
ajst-32481	38	26	thereby	thereby	ADV
ajst-32481	38	27	modulating	modulate	VERB
ajst-32481	38	28	host	host	NOUN
ajst-32481	38	29	immune	immune	ADJ
ajst-32481	38	30	activity[10	activity[10	CCONJ
ajst-32481	38	31	]	]	PUNCT
ajst-32481	38	32	.	.	PUNCT
ajst-32481	39	1	metabolically	metabolically	NOUN
ajst-32481	39	2	,	,	PUNCT
ajst-32481	39	3	the	the	DET
ajst-32481	39	4	gut	gut	NOUN
ajst-32481	39	5	microbiome	microbiome	NOUN
ajst-32481	39	6	is	be	AUX
ajst-32481	39	7	deeply	deeply	ADV
ajst-32481	39	8	involved	involve	VERB
ajst-32481	39	9	in	in	ADP
ajst-32481	39	10	nutrient	nutrient	NOUN
ajst-32481	39	11	processing	processing	NOUN
ajst-32481	39	12	,	,	PUNCT
ajst-32481	39	13	being	be	AUX
ajst-32481	39	14	one	one	NUM
ajst-32481	39	15	of	of	ADP
ajst-32481	39	16	the	the	DET
ajst-32481	39	17	most	most	ADV
ajst-32481	39	18	metabolically	metabolically	ADV
ajst-32481	39	19	active	active	ADJ
ajst-32481	39	20	sites	site	NOUN
ajst-32481	39	21	in	in	ADP
ajst-32481	39	22	the	the	DET
ajst-32481	39	23	body	body	NOUN
ajst-32481	39	24	.	.	PUNCT
ajst-32481	40	1	gut	gut	NOUN
ajst-32481	40	2	microbes	microbe	NOUN
ajst-32481	40	3	encode	encode	VERB
ajst-32481	40	4	numerous	numerous	ADJ
ajst-32481	40	5	carbohydrate	carbohydrate	NOUN
ajst-32481	40	6	-	-	PUNCT
ajst-32481	40	7	active	active	ADJ
ajst-32481	40	8	enzymes	enzyme	NOUN
ajst-32481	40	9	that	that	PRON
ajst-32481	40	10	break	break	VERB
ajst-32481	40	11	down	down	ADP
ajst-32481	40	12	complex	complex	ADJ
ajst-32481	40	13	carbohydrates	carbohydrate	NOUN
ajst-32481	40	14	into	into	ADP
ajst-32481	40	15	scfas[11	scfas[11	NOUN
ajst-32481	40	16	]	]	PUNCT
ajst-32481	40	17	.	.	PUNCT
ajst-32481	41	1	these	these	DET
ajst-32481	41	2	metabolites	metabolite	NOUN
ajst-32481	41	3	not	not	PART
ajst-32481	41	4	only	only	ADV
ajst-32481	41	5	supply	supply	VERB
ajst-32481	41	6	energy	energy	NOUN
ajst-32481	41	7	for	for	ADP
ajst-32481	41	8	microbes	microbe	NOUN
ajst-32481	41	9	themselves	themselves	PRON
ajst-32481	41	10	but	but	CCONJ
ajst-32481	41	11	are	be	AUX
ajst-32481	41	12	also	also	ADV
ajst-32481	41	13	absorbed	absorb	VERB
ajst-32481	41	14	by	by	ADP
ajst-32481	41	15	host	host	NOUN
ajst-32481	41	16	cells	cell	NOUN
ajst-32481	41	17	,	,	PUNCT
ajst-32481	41	18	contributing	contribute	VERB
ajst-32481	41	19	to	to	ADP
ajst-32481	41	20	energy	energy	NOUN
ajst-32481	41	21	metabolism	metabolism	NOUN
ajst-32481	41	22	and	and	CCONJ
ajst-32481	41	23	regulation	regulation	NOUN
ajst-32481	41	24	of	of	ADP
ajst-32481	41	25	intestinal	intestinal	ADJ
ajst-32481	41	26	barrier	barrier	NOUN
ajst-32481	41	27	function	function	NOUN
ajst-32481	41	28	.	.	PUNCT
ajst-32481	42	1	at	at	ADP
ajst-32481	42	2	the	the	DET
ajst-32481	42	3	same	same	ADJ
ajst-32481	42	4	time	time	NOUN
ajst-32481	42	5	,	,	PUNCT
ajst-32481	42	6	the	the	DET
ajst-32481	42	7	gut	gut	NOUN
ajst-32481	42	8	microbiota	microbiota	NOUN
ajst-32481	42	9	establishes	establish	VERB
ajst-32481	42	10	a	a	DET
ajst-32481	42	11	bidirectional	bidirectional	ADJ
ajst-32481	42	12	regulatory	regulatory	ADJ
ajst-32481	42	13	network	network	NOUN
ajst-32481	42	14	with	with	ADP
ajst-32481	42	15	the	the	DET
ajst-32481	42	16	nervous	nervous	ADJ
ajst-32481	42	17	system	system	NOUN
ajst-32481	42	18	through	through	ADP
ajst-32481	42	19	the	the	DET
ajst-32481	42	20	gut	gut	NOUN
ajst-32481	42	21	-	-	PUNCT
ajst-32481	42	22	brain	brain	NOUN
ajst-32481	42	23	axis	axis	NOUN
ajst-32481	42	24	(	(	PUNCT
ajst-32481	42	25	gba	gba	NOUN
ajst-32481	42	26	)	)	PUNCT
ajst-32481	42	27	.	.	PUNCT
ajst-32481	43	1	this	this	DET
ajst-32481	43	2	axis	axis	ADJ
ajst-32481	43	3	modulates	modulate	NOUN
ajst-32481	43	4	brain	brain	NOUN
ajst-32481	43	5	activity	activity	NOUN
ajst-32481	43	6	in	in	ADP
ajst-32481	43	7	multiple	multiple	ADJ
ajst-32481	43	8	dimensions	dimension	NOUN
ajst-32481	43	9	by	by	ADP
ajst-32481	43	10	promoting	promote	VERB
ajst-32481	43	11	immune	immune	ADJ
ajst-32481	43	12	responses	response	NOUN
ajst-32481	43	13	,	,	PUNCT
ajst-32481	43	14	influencing	influence	VERB
ajst-32481	43	15	the	the	DET
ajst-32481	43	16	integrity	integrity	NOUN
ajst-32481	43	17	of	of	ADP
ajst-32481	43	18	the	the	DET
ajst-32481	43	19	blood	blood	NOUN
ajst-32481	43	20	-	-	PUNCT
ajst-32481	43	21	brain	brain	NOUN
ajst-32481	43	22	barrier	barrier	NOUN
ajst-32481	43	23	(	(	PUNCT
ajst-32481	43	24	bbb	bbb	NOUN
ajst-32481	43	25	)	)	PUNCT
ajst-32481	43	26	,	,	PUNCT
ajst-32481	43	27	and	and	CCONJ
ajst-32481	43	28	shaping	shape	VERB
ajst-32481	43	29	neurophysiological	neurophysiological	ADJ
ajst-32481	43	30	processes[12	processes[12	PROPN
ajst-32481	43	31	]	]	X
ajst-32481	43	32	.	.	PUNCT
ajst-32481	44	1	2.3	2.3	NUM
ajst-32481	44	2	pathological	pathological	ADJ
ajst-32481	44	3	consequences	consequence	NOUN
ajst-32481	44	4	of	of	ADP
ajst-32481	44	5	gut	gut	NOUN
ajst-32481	44	6	microbiome	microbiome	ADJ
ajst-32481	44	7	dysbiosis	dysbiosis	NOUN
ajst-32481	44	8	host	host	NOUN
ajst-32481	44	9	health	health	NOUN
ajst-32481	44	10	depends	depend	VERB
ajst-32481	44	11	to	to	ADP
ajst-32481	44	12	a	a	DET
ajst-32481	44	13	large	large	ADJ
ajst-32481	44	14	extent	extent	NOUN
ajst-32481	44	15	on	on	ADP
ajst-32481	44	16	microbial	microbial	ADJ
ajst-32481	44	17	homeostasis	homeostasis	NOUN
ajst-32481	44	18	in	in	ADP
ajst-32481	44	19	the	the	DET
ajst-32481	44	20	gut	gut	NOUN
ajst-32481	44	21	.	.	PUNCT
ajst-32481	45	1	dysbiosis	dysbiosis	NOUN
ajst-32481	45	2	may	may	AUX
ajst-32481	45	3	directly	directly	ADV
ajst-32481	45	4	or	or	CCONJ
ajst-32481	45	5	indirectly	indirectly	ADV
ajst-32481	45	6	lead	lead	VERB
ajst-32481	45	7	to	to	ADP
ajst-32481	45	8	diseases	disease	NOUN
ajst-32481	45	9	such	such	ADJ
ajst-32481	45	10	as	as	ADP
ajst-32481	45	11	diabetes	diabetes	NOUN
ajst-32481	45	12	,	,	PUNCT
ajst-32481	45	13	obesity	obesity	NOUN
ajst-32481	45	14	,	,	PUNCT
ajst-32481	45	15	inflammatory	inflammatory	ADJ
ajst-32481	45	16	bowel	bowel	NOUN
ajst-32481	45	17	disease	disease	NOUN
ajst-32481	45	18	(	(	PUNCT
ajst-32481	45	19	ibd	ibd	PROPN
ajst-32481	45	20	)	)	PUNCT
ajst-32481	45	21	,	,	PUNCT
ajst-32481	45	22	and	and	CCONJ
ajst-32481	45	23	certain	certain	ADJ
ajst-32481	45	24	neurodevelopmental	neurodevelopmental	ADJ
ajst-32481	45	25	disorders	disorder	NOUN
ajst-32481	45	26	.	.	PUNCT
ajst-32481	46	1	for	for	ADP
ajst-32481	46	2	instance	instance	NOUN
ajst-32481	46	3	,	,	PUNCT
ajst-32481	46	4	metagenomic	metagenomic	ADJ
ajst-32481	46	5	studies	study	NOUN
ajst-32481	46	6	of	of	ADP
ajst-32481	46	7	ibd	ibd	NOUN
ajst-32481	46	8	patients	patient	NOUN
ajst-32481	46	9	have	have	AUX
ajst-32481	46	10	shown	show	VERB
ajst-32481	46	11	significantly	significantly	ADV
ajst-32481	46	12	reduced	reduce	VERB
ajst-32481	46	13	gut	gut	NOUN
ajst-32481	46	14	microbial	microbial	ADJ
ajst-32481	46	15	diversity	diversity	NOUN
ajst-32481	46	16	,	,	PUNCT
ajst-32481	46	17	with	with	ADP
ajst-32481	46	18	decreased	decrease	VERB
ajst-32481	46	19	abundance	abundance	NOUN
ajst-32481	46	20	of	of	ADP
ajst-32481	46	21	beneficial	beneficial	ADJ
ajst-32481	46	22	bacteria	bacteria	NOUN
ajst-32481	46	23	(	(	PUNCT
ajst-32481	46	24	e.g.	e.g.	ADV
ajst-32481	46	25	,	,	PUNCT
ajst-32481	46	26	bifidobacterium	bifidobacterium	NOUN
ajst-32481	46	27	)	)	PUNCT
ajst-32481	46	28	and	and	CCONJ
ajst-32481	46	29	increased	increase	VERB
ajst-32481	46	30	abundance	abundance	NOUN
ajst-32481	46	31	of	of	ADP
ajst-32481	46	32	harmful	harmful	ADJ
ajst-32481	46	33	bacteria	bacteria	NOUN
ajst-32481	46	34	(	(	PUNCT
ajst-32481	46	35	e.g.	e.g.	ADV
ajst-32481	46	36	,	,	PUNCT
ajst-32481	46	37	clostridium	clostridium	NOUN
ajst-32481	46	38	difficile)[13	difficile)[13	PROPN
ajst-32481	46	39	]	]	PUNCT
ajst-32481	46	40	.	.	PUNCT
ajst-32481	47	1	this	this	DET
ajst-32481	47	2	imbalance	imbalance	NOUN
ajst-32481	47	3	compromises	compromise	VERB
ajst-32481	47	4	the	the	DET
ajst-32481	47	5	intestinal	intestinal	ADJ
ajst-32481	47	6	mucosal	mucosal	NOUN
ajst-32481	47	7	barrier	barrier	NOUN
ajst-32481	47	8	,	,	PUNCT
ajst-32481	47	9	increases	increase	VERB
ajst-32481	47	10	gut	gut	NOUN
ajst-32481	47	11	permeability	permeability	NOUN
ajst-32481	47	12	,	,	PUNCT
ajst-32481	47	13	and	and	CCONJ
ajst-32481	47	14	allows	allow	VERB
ajst-32481	47	15	harmful	harmful	ADJ
ajst-32481	47	16	microbes	microbe	NOUN
ajst-32481	47	17	and	and	CCONJ
ajst-32481	47	18	their	their	PRON
ajst-32481	47	19	metabolites	metabolite	NOUN
ajst-32481	47	20	to	to	PART
ajst-32481	47	21	enter	enter	VERB
ajst-32481	47	22	the	the	DET
ajst-32481	47	23	circulation	circulation	NOUN
ajst-32481	47	24	,	,	PUNCT
ajst-32481	47	25	eliciting	elicit	VERB
ajst-32481	47	26	systemic	systemic	ADJ
ajst-32481	47	27	inflammation	inflammation	NOUN
ajst-32481	47	28	.	.	PUNCT
ajst-32481	48	1	other	other	ADJ
ajst-32481	48	2	studies	study	NOUN
ajst-32481	48	3	suggest	suggest	VERB
ajst-32481	48	4	that	that	SCONJ
ajst-32481	48	5	gut	gut	NOUN
ajst-32481	48	6	dysbiosis	dysbiosis	NOUN
ajst-32481	48	7	may	may	AUX
ajst-32481	48	8	contribute	contribute	VERB
ajst-32481	48	9	to	to	ADP
ajst-32481	48	10	neurological	neurological	ADJ
ajst-32481	48	11	disorders	disorder	NOUN
ajst-32481	48	12	via	via	ADP
ajst-32481	48	13	a	a	DET
ajst-32481	48	14	“	"	PUNCT
ajst-32481	48	15	gutinflammation	gutinflammation	NOUN
ajst-32481	48	16	-	-	PUNCT
ajst-32481	48	17	neurodegeneration	neurodegeneration	NOUN
ajst-32481	48	18	”	"	PUNCT
ajst-32481	48	19	pathway	pathway	NOUN
ajst-32481	48	20	.	.	PUNCT
ajst-32481	49	1	specifically	specifically	ADV
ajst-32481	49	2	,	,	PUNCT
ajst-32481	49	3	large	large	ADJ
ajst-32481	49	4	-	-	PUNCT
ajst-32481	49	5	scale	scale	NOUN
ajst-32481	49	6	microbial	microbial	ADJ
ajst-32481	49	7	imbalance	imbalance	NOUN
ajst-32481	49	8	can	can	AUX
ajst-32481	49	9	impair	impair	VERB
ajst-32481	49	10	bbb	bbb	PROPN
ajst-32481	49	11	integrity	integrity	NOUN
ajst-32481	49	12	and	and	CCONJ
ajst-32481	49	13	activate	activate	VERB
ajst-32481	49	14	microglia	microglia	NOUN
ajst-32481	49	15	,	,	PUNCT
ajst-32481	49	16	triggering	trigger	VERB
ajst-32481	49	17	neuroinflammatory	neuroinflammatory	NOUN
ajst-32481	49	18	diseases[2	diseases[2	PROPN
ajst-32481	49	19	]	]	PUNCT
ajst-32481	49	20	.	.	PUNCT
ajst-32481	50	1	additionally	additionally	ADV
ajst-32481	50	2	,	,	PUNCT
ajst-32481	50	3	dysbiosis	dysbiosis	NOUN
ajst-32481	50	4	may	may	AUX
ajst-32481	50	5	lead	lead	VERB
ajst-32481	50	6	to	to	ADP
ajst-32481	50	7	accumulation	accumulation	NOUN
ajst-32481	50	8	of	of	ADP
ajst-32481	50	9	neurotoxic	neurotoxic	ADJ
ajst-32481	50	10	metabolites	metabolite	NOUN
ajst-32481	50	11	that	that	PRON
ajst-32481	50	12	promote	promote	VERB
ajst-32481	50	13	aβ	aβ	PRON
ajst-32481	50	14	deposition	deposition	NOUN
ajst-32481	50	15	,	,	PUNCT
ajst-32481	50	16	tau	tau	PROPN
ajst-32481	50	17	hyperphosphorylation	hyperphosphorylation	NOUN
ajst-32481	50	18	,	,	PUNCT
ajst-32481	50	19	and	and	CCONJ
ajst-32481	50	20	neuronal	neuronal	ADJ
ajst-32481	50	21	dysfunction	dysfunction	NOUN
ajst-32481	50	22	,	,	PUNCT
ajst-32481	50	23	directly	directly	ADV
ajst-32481	50	24	damaging	damage	VERB
ajst-32481	50	25	the	the	DET
ajst-32481	50	26	function	function	NOUN
ajst-32481	50	27	of	of	ADP
ajst-32481	50	28	neurons[14	neurons[14	PROPN
ajst-32481	50	29	]	]	PUNCT
ajst-32481	50	30	.	.	PUNCT
ajst-32481	51	1	furthermore	furthermore	ADV
ajst-32481	51	2	,	,	PUNCT
ajst-32481	51	3	small	small	ADJ
ajst-32481	51	4	molecules	molecule	NOUN
ajst-32481	51	5	and	and	CCONJ
ajst-32481	51	6	hormones	hormone	NOUN
ajst-32481	51	7	derived	derive	VERB
ajst-32481	51	8	from	from	ADP
ajst-32481	51	9	dysbiotic	dysbiotic	ADJ
ajst-32481	51	10	microbiota	microbiota	NOUN
ajst-32481	51	11	,	,	PUNCT
ajst-32481	51	12	although	although	SCONJ
ajst-32481	51	13	unable	unable	ADJ
ajst-32481	51	14	to	to	PART
ajst-32481	51	15	cross	cross	VERB
ajst-32481	51	16	the	the	DET
ajst-32481	51	17	bbb	bbb	NOUN
ajst-32481	51	18	directly	directly	ADV
ajst-32481	51	19	,	,	PUNCT
ajst-32481	51	20	may	may	AUX
ajst-32481	51	21	act	act	VERB
ajst-32481	51	22	indirectly	indirectly	ADV
ajst-32481	51	23	via	via	ADP
ajst-32481	51	24	peripheral	peripheral	ADJ
ajst-32481	51	25	immune	immune	ADJ
ajst-32481	51	26	activation	activation	NOUN
ajst-32481	51	27	or	or	CCONJ
ajst-32481	51	28	vagus	vagus	NOUN
ajst-32481	51	29	nerve	nerve	NOUN
ajst-32481	51	30	signaling	signal	VERB
ajst-32481	51	31	,	,	PUNCT
ajst-32481	51	32	thereby	thereby	ADV
ajst-32481	51	33	aggravating	aggravate	VERB
ajst-32481	51	34	neuropathology	neuropathology	NOUN
ajst-32481	51	35	.	.	PUNCT
ajst-32481	52	1	3	3	X
ajst-32481	52	2	.	.	X
ajst-32481	52	3	alzheimer	alzheimer	PROPN
ajst-32481	52	4	’s	’s	PART
ajst-32481	52	5	disease	disease	NOUN
ajst-32481	52	6	3.1	3.1	NUM
ajst-32481	52	7	pathological	pathological	ADJ
ajst-32481	52	8	progression	progression	NOUN
ajst-32481	52	9	of	of	ADP
ajst-32481	52	10	alzheimer	alzheimer	PROPN
ajst-32481	52	11	’s	’s	PART
ajst-32481	52	12	disease	disease	NOUN
ajst-32481	52	13	figure	figure	NOUN
ajst-32481	52	14	3	3	NUM
ajst-32481	52	15	.	.	PUNCT
ajst-32481	52	16	mechanisms	mechanism	NOUN
ajst-32481	52	17	of	of	ADP
ajst-32481	52	18	ad	ad	NOUN
ajst-32481	52	19	pathogenesis	pathogenesis	NOUN
ajst-32481	52	20	[	[	X
ajst-32481	52	21	15	15	NUM
ajst-32481	52	22	]	]	PUNCT
ajst-32481	52	23	.	.	PUNCT
ajst-32481	53	1	this	this	PRON
ajst-32481	53	2	involves	involve	VERB
ajst-32481	53	3	aβ	aβ	ADP
ajst-32481	53	4	deposition	deposition	NOUN
ajst-32481	53	5	,	,	PUNCT
ajst-32481	53	6	tau	tau	PROPN
ajst-32481	53	7	hyperphosphorylation	hyperphosphorylation	NOUN
ajst-32481	53	8	,	,	PUNCT
ajst-32481	53	9	and	and	CCONJ
ajst-32481	53	10	apolipoprotein	apolipoprotein	ADJ
ajst-32481	53	11	e	e	X
ajst-32481	53	12	(	(	PUNCT
ajst-32481	53	13	apoe)-related	apoe)-relate	VERB
ajst-32481	53	14	synaptic	synaptic	ADJ
ajst-32481	53	15	dysfunction	dysfunction	NOUN
ajst-32481	53	16	.	.	PUNCT
ajst-32481	54	1	101	101	NUM
ajst-32481	54	2	ad	ad	NOUN
ajst-32481	54	3	is	be	AUX
ajst-32481	54	4	a	a	DET
ajst-32481	54	5	neurodegenerative	neurodegenerative	ADJ
ajst-32481	54	6	disorder	disorder	NOUN
ajst-32481	54	7	with	with	ADP
ajst-32481	54	8	progressive	progressive	ADJ
ajst-32481	54	9	cognitive	cognitive	ADJ
ajst-32481	54	10	decline	decline	NOUN
ajst-32481	54	11	as	as	ADP
ajst-32481	54	12	its	its	PRON
ajst-32481	54	13	core	core	ADJ
ajst-32481	54	14	clinical	clinical	ADJ
ajst-32481	54	15	feature	feature	NOUN
ajst-32481	54	16	.	.	PUNCT
ajst-32481	55	1	multiple	multiple	ADJ
ajst-32481	55	2	hypotheses	hypothesis	NOUN
ajst-32481	55	3	coexist	coexist	VERB
ajst-32481	55	4	to	to	PART
ajst-32481	55	5	explain	explain	VERB
ajst-32481	55	6	its	its	PRON
ajst-32481	55	7	pathology	pathology	NOUN
ajst-32481	55	8	.	.	PUNCT
ajst-32481	56	1	the	the	DET
ajst-32481	56	2	hallmark	hallmark	ADJ
ajst-32481	56	3	pathological	pathological	ADJ
ajst-32481	56	4	features	feature	NOUN
ajst-32481	56	5	include	include	VERB
ajst-32481	56	6	excessive	excessive	ADJ
ajst-32481	56	7	aβ	aβ	ADP
ajst-32481	56	8	deposition	deposition	NOUN
ajst-32481	56	9	,	,	PUNCT
ajst-32481	56	10	abnormal	abnormal	ADJ
ajst-32481	56	11	phosphorylation	phosphorylation	NOUN
ajst-32481	56	12	of	of	ADP
ajst-32481	56	13	microtubule	microtubule	NOUN
ajst-32481	56	14	-	-	PUNCT
ajst-32481	56	15	associated	associate	VERB
ajst-32481	56	16	tau	tau	PROPN
ajst-32481	56	17	protein	protein	NOUN
ajst-32481	56	18	,	,	PUNCT
ajst-32481	56	19	chronic	chronic	ADJ
ajst-32481	56	20	neuroinflammation	neuroinflammation	NOUN
ajst-32481	56	21	,	,	PUNCT
ajst-32481	56	22	and	and	CCONJ
ajst-32481	56	23	synaptic	synaptic	ADJ
ajst-32481	56	24	dysfunction	dysfunction	NOUN
ajst-32481	56	25	.	.	PUNCT
ajst-32481	57	1	aβ	aβ	DET
ajst-32481	57	2	accumulation	accumulation	NOUN
ajst-32481	57	3	is	be	AUX
ajst-32481	57	4	a	a	DET
ajst-32481	57	5	defining	define	VERB
ajst-32481	57	6	pathological	pathological	ADJ
ajst-32481	57	7	marker	marker	NOUN
ajst-32481	57	8	of	of	ADP
ajst-32481	57	9	ad	ad	NOUN
ajst-32481	57	10	.	.	PUNCT
ajst-32481	58	1	aβ	aβ	DET
ajst-32481	58	2	peptides	peptide	NOUN
ajst-32481	58	3	are	be	AUX
ajst-32481	58	4	derived	derive	VERB
ajst-32481	58	5	from	from	ADP
ajst-32481	58	6	amyloid	amyloid	NOUN
ajst-32481	58	7	precursor	precursor	NOUN
ajst-32481	58	8	protein	protein	NOUN
ajst-32481	58	9	through	through	ADP
ajst-32481	58	10	the	the	DET
ajst-32481	58	11	abnormal	abnormal	ADJ
ajst-32481	58	12	cleavage	cleavage	NOUN
ajst-32481	58	13	by	by	ADP
ajst-32481	58	14	secretases	secretase	NOUN
ajst-32481	58	15	.	.	PUNCT
ajst-32481	59	1	under	under	ADP
ajst-32481	59	2	pathological	pathological	ADJ
ajst-32481	59	3	conditions	condition	NOUN
ajst-32481	59	4	,	,	PUNCT
ajst-32481	59	5	soluble	soluble	ADJ
ajst-32481	59	6	aβ	aβ	NOUN
ajst-32481	59	7	peptides	peptide	NOUN
ajst-32481	59	8	undergo	undergo	VERB
ajst-32481	59	9	oligomerization	oligomerization	NOUN
ajst-32481	59	10	and	and	CCONJ
ajst-32481	59	11	aggregation	aggregation	NOUN
ajst-32481	59	12	,	,	PUNCT
ajst-32481	59	13	impair	impair	VERB
ajst-32481	59	14	synaptic	synaptic	ADJ
ajst-32481	59	15	signaling	signaling	NOUN
ajst-32481	59	16	,	,	PUNCT
ajst-32481	59	17	and	and	CCONJ
ajst-32481	59	18	eventually	eventually	ADV
ajst-32481	59	19	form	form	VERB
ajst-32481	59	20	insoluble	insoluble	ADJ
ajst-32481	59	21	neurotoxic	neurotoxic	ADJ
ajst-32481	59	22	plaques	plaque	NOUN
ajst-32481	59	23	,	,	PUNCT
ajst-32481	59	24	leading	lead	VERB
ajst-32481	59	25	to	to	ADP
ajst-32481	59	26	widespread	widespread	ADJ
ajst-32481	59	27	neuronal	neuronal	ADJ
ajst-32481	59	28	death	death	NOUN
ajst-32481	59	29	.	.	PUNCT
ajst-32481	60	1	tau	tau	PROPN
ajst-32481	60	2	protein	protein	NOUN
ajst-32481	60	3	,	,	PUNCT
ajst-32481	60	4	a	a	DET
ajst-32481	60	5	microtubule	microtubule	NOUN
ajst-32481	60	6	-	-	PUNCT
ajst-32481	60	7	associated	associate	VERB
ajst-32481	60	8	protein	protein	NOUN
ajst-32481	60	9	,	,	PUNCT
ajst-32481	60	10	normally	normally	ADV
ajst-32481	60	11	undergoes	undergo	VERB
ajst-32481	60	12	reversible	reversible	ADJ
ajst-32481	60	13	phosphorylation	phosphorylation	NOUN
ajst-32481	60	14	to	to	PART
ajst-32481	60	15	regulate	regulate	VERB
ajst-32481	60	16	microtubule	microtubule	NOUN
ajst-32481	60	17	stability	stability	NOUN
ajst-32481	60	18	.	.	PUNCT
ajst-32481	61	1	in	in	ADP
ajst-32481	61	2	ad	ad	NOUN
ajst-32481	61	3	,	,	PUNCT
ajst-32481	61	4	tau	tau	PROPN
ajst-32481	61	5	phosphorylation	phosphorylation	NOUN
ajst-32481	61	6	is	be	AUX
ajst-32481	61	7	markedly	markedly	ADV
ajst-32481	61	8	elevated	elevate	VERB
ajst-32481	61	9	,	,	PUNCT
ajst-32481	61	10	especially	especially	ADV
ajst-32481	61	11	at	at	ADP
ajst-32481	61	12	certain	certain	ADJ
ajst-32481	61	13	amino	amino	NOUN
ajst-32481	61	14	acid	acid	NOUN
ajst-32481	61	15	residues	residue	NOUN
ajst-32481	61	16	(	(	PUNCT
ajst-32481	61	17	e.g.	e.g.	ADV
ajst-32481	61	18	,	,	PUNCT
ajst-32481	61	19	tyrosine	tyrosine	NOUN
ajst-32481	61	20	and	and	CCONJ
ajst-32481	61	21	threonine)[14	threonine)[14	NUM
ajst-32481	61	22	]	]	PUNCT
ajst-32481	61	23	.	.	PUNCT
ajst-32481	62	1	this	this	DET
ajst-32481	62	2	aberrant	aberrant	ADJ
ajst-32481	62	3	phosphorylation	phosphorylation	NOUN
ajst-32481	62	4	alters	alter	VERB
ajst-32481	62	5	tau	tau	PROPN
ajst-32481	62	6	conformation	conformation	NOUN
ajst-32481	62	7	,	,	PUNCT
ajst-32481	62	8	causing	cause	VERB
ajst-32481	62	9	its	its	PRON
ajst-32481	62	10	aggregation	aggregation	NOUN
ajst-32481	62	11	into	into	ADP
ajst-32481	62	12	intracellular	intracellular	ADJ
ajst-32481	62	13	neurofibrillary	neurofibrillary	ADJ
ajst-32481	62	14	tangles	tangle	NOUN
ajst-32481	62	15	(	(	PUNCT
ajst-32481	62	16	nfts	nft	NOUN
ajst-32481	62	17	)	)	PUNCT
ajst-32481	62	18	.	.	PUNCT
ajst-32481	63	1	the	the	DET
ajst-32481	63	2	accumulation	accumulation	NOUN
ajst-32481	63	3	of	of	ADP
ajst-32481	63	4	nfts	nft	NOUN
ajst-32481	63	5	disrupts	disrupt	VERB
ajst-32481	63	6	neuronal	neuronal	ADJ
ajst-32481	63	7	function	function	NOUN
ajst-32481	63	8	and	and	CCONJ
ajst-32481	63	9	induces	induce	VERB
ajst-32481	63	10	cell	cell	NOUN
ajst-32481	63	11	death	death	NOUN
ajst-32481	63	12	.	.	PUNCT
ajst-32481	64	1	recent	recent	ADJ
ajst-32481	64	2	studies	study	NOUN
ajst-32481	64	3	suggest	suggest	VERB
ajst-32481	64	4	that	that	SCONJ
ajst-32481	64	5	soluble	soluble	ADJ
ajst-32481	64	6	tau	tau	PROPN
ajst-32481	64	7	assemblies	assembly	NOUN
ajst-32481	64	8	may	may	AUX
ajst-32481	64	9	act	act	VERB
ajst-32481	64	10	as	as	ADP
ajst-32481	64	11	earlier	early	ADJ
ajst-32481	64	12	pathological	pathological	ADJ
ajst-32481	64	13	drivers	driver	NOUN
ajst-32481	64	14	preceding	precede	VERB
ajst-32481	64	15	nft	nft	PROPN
ajst-32481	64	16	formation	formation	NOUN
ajst-32481	65	1	[	[	X
ajst-32481	65	2	16	16	NUM
ajst-32481	65	3	]	]	PUNCT
ajst-32481	65	4	.	.	PUNCT
ajst-32481	66	1	synaptic	synaptic	ADJ
ajst-32481	66	2	dysfunction	dysfunction	NOUN
ajst-32481	66	3	in	in	ADP
ajst-32481	66	4	ad	ad	NOUN
ajst-32481	66	5	results	result	NOUN
ajst-32481	66	6	from	from	ADP
ajst-32481	66	7	multiple	multiple	ADJ
ajst-32481	66	8	synergistic	synergistic	ADJ
ajst-32481	66	9	neurotoxic	neurotoxic	ADJ
ajst-32481	66	10	mechanisms	mechanism	NOUN
ajst-32481	66	11	.	.	PUNCT
ajst-32481	67	1	aβ	aβ	PRON
ajst-32481	67	2	oligomers	oligomer	NOUN
ajst-32481	67	3	accumulate	accumulate	VERB
ajst-32481	67	4	in	in	ADP
ajst-32481	67	5	dendritic	dendritic	ADJ
ajst-32481	67	6	spines	spine	NOUN
ajst-32481	67	7	,	,	PUNCT
ajst-32481	67	8	inducing	induce	VERB
ajst-32481	67	9	abnormal	abnormal	ADJ
ajst-32481	67	10	internalization	internalization	NOUN
ajst-32481	67	11	of	of	ADP
ajst-32481	67	12	n	n	CCONJ
ajst-32481	67	13	-	-	PUNCT
ajst-32481	67	14	methyl	methyl	NOUN
ajst-32481	67	15	-	-	PUNCT
ajst-32481	67	16	d	d	NOUN
ajst-32481	67	17	-	-	PUNCT
ajst-32481	67	18	aspartate	aspartate	ADJ
ajst-32481	67	19	receptors	receptor	NOUN
ajst-32481	67	20	(	(	PUNCT
ajst-32481	67	21	nmdars	nmdar	NOUN
ajst-32481	67	22	)	)	PUNCT
ajst-32481	67	23	,	,	PUNCT
ajst-32481	67	24	thereby	thereby	ADV
ajst-32481	67	25	weakening	weaken	VERB
ajst-32481	67	26	synaptic	synaptic	ADJ
ajst-32481	67	27	transmission	transmission	NOUN
ajst-32481	67	28	.	.	PUNCT
ajst-32481	68	1	consequently	consequently	ADV
ajst-32481	68	2	,	,	PUNCT
ajst-32481	68	3	synaptic	synaptic	ADJ
ajst-32481	68	4	dysfunction	dysfunction	NOUN
ajst-32481	68	5	is	be	AUX
ajst-32481	68	6	considered	consider	VERB
ajst-32481	68	7	the	the	DET
ajst-32481	68	8	most	most	ADV
ajst-32481	68	9	direct	direct	ADJ
ajst-32481	68	10	cellular	cellular	ADJ
ajst-32481	68	11	basis	basis	NOUN
ajst-32481	68	12	for	for	ADP
ajst-32481	68	13	cognitive	cognitive	ADJ
ajst-32481	68	14	decline	decline	NOUN
ajst-32481	68	15	in	in	ADP
ajst-32481	68	16	ad	ad	NOUN
ajst-32481	68	17	patients	patient	NOUN
ajst-32481	68	18	[	[	X
ajst-32481	68	19	17	17	NUM
ajst-32481	68	20	]	]	PUNCT
ajst-32481	68	21	.	.	PUNCT
ajst-32481	69	1	neuroinflammation	neuroinflammation	NOUN
ajst-32481	69	2	in	in	ADP
ajst-32481	69	3	ad	ad	NOUN
ajst-32481	69	4	is	be	AUX
ajst-32481	69	5	multidimensional	multidimensional	ADJ
ajst-32481	69	6	and	and	CCONJ
ajst-32481	69	7	self	self	NOUN
ajst-32481	69	8	-	-	PUNCT
ajst-32481	69	9	amplifying	amplifying	NOUN
ajst-32481	69	10	,	,	PUNCT
ajst-32481	69	11	involving	involve	VERB
ajst-32481	69	12	oxidative	oxidative	ADJ
ajst-32481	69	13	stress	stress	NOUN
ajst-32481	69	14	,	,	PUNCT
ajst-32481	69	15	cytokine	cytokine	ADJ
ajst-32481	69	16	networks	network	NOUN
ajst-32481	69	17	,	,	PUNCT
ajst-32481	69	18	and	and	CCONJ
ajst-32481	69	19	interactions	interaction	NOUN
ajst-32481	69	20	with	with	ADP
ajst-32481	69	21	neuropathological	neuropathological	ADJ
ajst-32481	69	22	features	feature	NOUN
ajst-32481	69	23	such	such	ADJ
ajst-32481	69	24	as	as	ADP
ajst-32481	69	25	nfts	nft	NOUN
ajst-32481	69	26	[	[	X
ajst-32481	69	27	18	18	NUM
ajst-32481	69	28	]	]	PUNCT
ajst-32481	69	29	.	.	PUNCT
ajst-32481	70	1	neuroinflammation	neuroinflammation	NOUN
ajst-32481	70	2	forms	form	VERB
ajst-32481	70	3	a	a	DET
ajst-32481	70	4	vicious	vicious	ADJ
ajst-32481	70	5	cycle	cycle	NOUN
ajst-32481	70	6	:	:	PUNCT
ajst-32481	70	7	cellular	cellular	ADJ
ajst-32481	70	8	damage	damage	NOUN
ajst-32481	70	9	triggers	trigger	VERB
ajst-32481	70	10	inflammation	inflammation	NOUN
ajst-32481	70	11	,	,	PUNCT
ajst-32481	70	12	and	and	CCONJ
ajst-32481	70	13	inflammation	inflammation	NOUN
ajst-32481	70	14	in	in	ADP
ajst-32481	70	15	turn	turn	NOUN
ajst-32481	70	16	exacerbates	exacerbate	VERB
ajst-32481	70	17	cellular	cellular	ADJ
ajst-32481	70	18	damage	damage	NOUN
ajst-32481	70	19	.	.	PUNCT
ajst-32481	71	1	for	for	ADP
ajst-32481	71	2	example	example	NOUN
ajst-32481	71	3	,	,	PUNCT
ajst-32481	71	4	tnf	tnf	PROPN
ajst-32481	71	5	-	-	PUNCT
ajst-32481	71	6	α	α	PROPN
ajst-32481	71	7	promotes	promote	VERB
ajst-32481	71	8	reactive	reactive	ADJ
ajst-32481	71	9	oxygen	oxygen	NOUN
ajst-32481	71	10	species	specie	NOUN
ajst-32481	71	11	(	(	PUNCT
ajst-32481	71	12	ros	ros	PROPN
ajst-32481	71	13	)	)	PUNCT
ajst-32481	71	14	generation	generation	NOUN
ajst-32481	71	15	,	,	PUNCT
ajst-32481	71	16	further	far	ADV
ajst-32481	71	17	activating	activate	VERB
ajst-32481	71	18	inflammatory	inflammatory	ADJ
ajst-32481	71	19	signaling	signal	VERB
ajst-32481	71	20	pathways	pathway	NOUN
ajst-32481	71	21	[	[	X
ajst-32481	71	22	18	18	NUM
ajst-32481	71	23	]	]	PUNCT
ajst-32481	71	24	.	.	PUNCT
ajst-32481	72	1	such	such	ADJ
ajst-32481	72	2	cyclical	cyclical	ADJ
ajst-32481	72	3	inflammation	inflammation	NOUN
ajst-32481	72	4	may	may	AUX
ajst-32481	72	5	be	be	AUX
ajst-32481	72	6	more	more	ADV
ajst-32481	72	7	amenable	amenable	ADJ
ajst-32481	72	8	to	to	ADP
ajst-32481	72	9	intervention	intervention	NOUN
ajst-32481	72	10	in	in	ADP
ajst-32481	72	11	early	early	ADJ
ajst-32481	72	12	disease	disease	NOUN
ajst-32481	72	13	stages	stage	NOUN
ajst-32481	72	14	but	but	CCONJ
ajst-32481	72	15	becomes	become	VERB
ajst-32481	72	16	increasingly	increasingly	ADV
ajst-32481	72	17	uncontrollable	uncontrollable	ADJ
ajst-32481	72	18	at	at	ADP
ajst-32481	72	19	later	later	ADJ
ajst-32481	72	20	stages	stage	NOUN
ajst-32481	72	21	.	.	PUNCT
ajst-32481	73	1	3.2	3.2	NUM
ajst-32481	73	2	immune	immune	ADJ
ajst-32481	73	3	cells	cell	NOUN
ajst-32481	73	4	in	in	ADP
ajst-32481	73	5	the	the	DET
ajst-32481	73	6	central	central	ADJ
ajst-32481	73	7	nervous	nervous	ADJ
ajst-32481	73	8	system	system	NOUN
ajst-32481	73	9	although	although	SCONJ
ajst-32481	73	10	neurons	neuron	NOUN
ajst-32481	73	11	are	be	AUX
ajst-32481	73	12	the	the	DET
ajst-32481	73	13	principal	principal	ADJ
ajst-32481	73	14	cellular	cellular	ADJ
ajst-32481	73	15	components	component	NOUN
ajst-32481	73	16	of	of	ADP
ajst-32481	73	17	the	the	DET
ajst-32481	73	18	nervous	nervous	ADJ
ajst-32481	73	19	system	system	NOUN
ajst-32481	73	20	,	,	PUNCT
ajst-32481	73	21	the	the	DET
ajst-32481	73	22	central	central	ADJ
ajst-32481	73	23	nervous	nervous	ADJ
ajst-32481	73	24	system	system	NOUN
ajst-32481	73	25	(	(	PUNCT
ajst-32481	73	26	cns	cns	NOUN
ajst-32481	73	27	)	)	PUNCT
ajst-32481	73	28	also	also	ADV
ajst-32481	73	29	contains	contain	VERB
ajst-32481	73	30	various	various	ADJ
ajst-32481	73	31	glial	glial	ADJ
ajst-32481	73	32	cells	cell	NOUN
ajst-32481	73	33	.	.	PUNCT
ajst-32481	74	1	microglia	microglia	ADJ
ajst-32481	74	2	,	,	PUNCT
ajst-32481	74	3	the	the	DET
ajst-32481	74	4	only	only	ADJ
ajst-32481	74	5	resident	resident	ADJ
ajst-32481	74	6	immune	immune	ADJ
ajst-32481	74	7	cells	cell	NOUN
ajst-32481	74	8	in	in	ADP
ajst-32481	74	9	the	the	DET
ajst-32481	74	10	cns	cns	NOUN
ajst-32481	74	11	,	,	PUNCT
ajst-32481	74	12	account	account	VERB
ajst-32481	74	13	for	for	ADP
ajst-32481	74	14	approximately	approximately	ADV
ajst-32481	74	15	10	10	NUM
ajst-32481	74	16	-	-	SYM
ajst-32481	74	17	20	20	NUM
ajst-32481	74	18	%	%	NOUN
ajst-32481	74	19	of	of	ADP
ajst-32481	74	20	all	all	DET
ajst-32481	74	21	glial	glial	ADJ
ajst-32481	74	22	cells	cell	NOUN
ajst-32481	74	23	.	.	PUNCT
ajst-32481	75	1	in	in	ADP
ajst-32481	75	2	their	their	PRON
ajst-32481	75	3	resting	rest	VERB
ajst-32481	75	4	state	state	NOUN
ajst-32481	75	5	,	,	PUNCT
ajst-32481	75	6	microglia	microglia	NOUN
ajst-32481	75	7	continuously	continuously	ADV
ajst-32481	75	8	survey	survey	VERB
ajst-32481	75	9	the	the	DET
ajst-32481	75	10	neural	neural	ADJ
ajst-32481	75	11	microenvironment	microenvironment	NOUN
ajst-32481	75	12	to	to	PART
ajst-32481	75	13	maintain	maintain	VERB
ajst-32481	75	14	homeostasis	homeostasis	NOUN
ajst-32481	75	15	and	and	CCONJ
ajst-32481	75	16	regulate	regulate	VERB
ajst-32481	75	17	synaptic	synaptic	ADJ
ajst-32481	75	18	function	function	NOUN
ajst-32481	75	19	through	through	ADP
ajst-32481	75	20	synaptic	synaptic	ADJ
ajst-32481	75	21	pruning[19	pruning[19	NOUN
ajst-32481	75	22	]	]	PUNCT
ajst-32481	75	23	.	.	PUNCT
ajst-32481	76	1	when	when	SCONJ
ajst-32481	76	2	stimulated	stimulate	VERB
ajst-32481	76	3	by	by	ADP
ajst-32481	76	4	factors	factor	NOUN
ajst-32481	76	5	such	such	ADJ
ajst-32481	76	6	as	as	ADP
ajst-32481	76	7	aβ	aβ	PRON
ajst-32481	76	8	deposition	deposition	NOUN
ajst-32481	76	9	,	,	PUNCT
ajst-32481	76	10	microglia	microglia	NOUN
ajst-32481	76	11	become	become	VERB
ajst-32481	76	12	overactivated	overactivated	ADJ
ajst-32481	76	13	and	and	CCONJ
ajst-32481	76	14	release	release	VERB
ajst-32481	76	15	harmful	harmful	ADJ
ajst-32481	76	16	mediators	mediator	NOUN
ajst-32481	76	17	,	,	PUNCT
ajst-32481	76	18	including	include	VERB
ajst-32481	76	19	pro	pro	ADJ
ajst-32481	76	20	-	-	ADJ
ajst-32481	76	21	inflammatory	inflammatory	ADJ
ajst-32481	76	22	cytokines	cytokine	NOUN
ajst-32481	76	23	,	,	PUNCT
ajst-32481	76	24	reactive	reactive	ADJ
ajst-32481	76	25	oxygen	oxygen	NOUN
ajst-32481	76	26	species	specie	NOUN
ajst-32481	76	27	(	(	PUNCT
ajst-32481	76	28	ros	ros	PROPN
ajst-32481	76	29	)	)	PUNCT
ajst-32481	76	30	,	,	PUNCT
ajst-32481	76	31	and	and	CCONJ
ajst-32481	76	32	reactive	reactive	ADJ
ajst-32481	76	33	nitrogen	nitrogen	NOUN
ajst-32481	76	34	species	specie	NOUN
ajst-32481	76	35	(	(	PUNCT
ajst-32481	76	36	rns	rns	PROPN
ajst-32481	76	37	)	)	PUNCT
ajst-32481	76	38	,	,	PUNCT
ajst-32481	76	39	thereby	thereby	ADV
ajst-32481	76	40	driving	drive	VERB
ajst-32481	76	41	neuroinflammation[20	neuroinflammation[20	ADV
ajst-32481	76	42	]	]	PUNCT
ajst-32481	76	43	.	.	PUNCT
ajst-32481	77	1	neuropathological	neuropathological	ADJ
ajst-32481	77	2	studies	study	NOUN
ajst-32481	77	3	reveal	reveal	VERB
ajst-32481	77	4	that	that	SCONJ
ajst-32481	77	5	microglia	microglia	NOUN
ajst-32481	77	6	in	in	ADP
ajst-32481	77	7	the	the	DET
ajst-32481	77	8	brains	brain	NOUN
ajst-32481	77	9	of	of	ADP
ajst-32481	77	10	ad	ad	NOUN
ajst-32481	77	11	patients	patient	NOUN
ajst-32481	77	12	are	be	AUX
ajst-32481	77	13	markedly	markedly	ADV
ajst-32481	77	14	activated	activate	VERB
ajst-32481	77	15	,	,	PUNCT
ajst-32481	77	16	underscoring	underscore	VERB
ajst-32481	77	17	their	their	PRON
ajst-32481	77	18	close	close	ADJ
ajst-32481	77	19	involvement	involvement	NOUN
ajst-32481	77	20	in	in	ADP
ajst-32481	77	21	ad	ad	NOUN
ajst-32481	77	22	progression	progression	NOUN
ajst-32481	77	23	.	.	PUNCT
ajst-32481	78	1	in	in	ADP
ajst-32481	78	2	early	early	ADJ
ajst-32481	78	3	ad	ad	NOUN
ajst-32481	78	4	,	,	PUNCT
ajst-32481	78	5	microglia	microglia	NOUN
ajst-32481	78	6	predominantly	predominantly	ADV
ajst-32481	78	7	exhibit	exhibit	VERB
ajst-32481	78	8	a	a	DET
ajst-32481	78	9	neuroprotective	neuroprotective	ADJ
ajst-32481	78	10	m2	m2	PROPN
ajst-32481	78	11	phenotype	phenotype	NOUN
ajst-32481	78	12	,	,	PUNCT
ajst-32481	78	13	relying	rely	VERB
ajst-32481	78	14	on	on	ADP
ajst-32481	78	15	oxidative	oxidative	ADJ
ajst-32481	78	16	phosphorylation	phosphorylation	NOUN
ajst-32481	78	17	to	to	PART
ajst-32481	78	18	clear	clear	VERB
ajst-32481	78	19	aβ	aβ	DET
ajst-32481	78	20	deposits	deposit	NOUN
ajst-32481	78	21	.	.	PUNCT
ajst-32481	79	1	however	however	ADV
ajst-32481	79	2	,	,	PUNCT
ajst-32481	79	3	as	as	SCONJ
ajst-32481	79	4	the	the	DET
ajst-32481	79	5	disease	disease	NOUN
ajst-32481	79	6	progresses	progress	VERB
ajst-32481	79	7	,	,	PUNCT
ajst-32481	79	8	microglia	microglia	ADJ
ajst-32481	79	9	shift	shift	NOUN
ajst-32481	79	10	toward	toward	ADP
ajst-32481	79	11	a	a	DET
ajst-32481	79	12	glycolysis	glycolysis	NOUN
ajst-32481	79	13	-	-	PUNCT
ajst-32481	79	14	dependent	dependent	ADJ
ajst-32481	79	15	m1	m1	NOUN
ajst-32481	79	16	phenotype	phenotype	NOUN
ajst-32481	79	17	,	,	PUNCT
ajst-32481	79	18	with	with	ADP
ajst-32481	79	19	impaired	impaired	ADJ
ajst-32481	79	20	aβ	aβ	NUM
ajst-32481	79	21	clearance	clearance	NOUN
ajst-32481	79	22	capacity[21	capacity[21	PROPN
ajst-32481	79	23	]	]	PUNCT
ajst-32481	79	24	.	.	PUNCT
ajst-32481	80	1	at	at	ADP
ajst-32481	80	2	the	the	DET
ajst-32481	80	3	same	same	ADJ
ajst-32481	80	4	time	time	NOUN
ajst-32481	80	5	,	,	PUNCT
ajst-32481	80	6	activated	activate	VERB
ajst-32481	80	7	microglia	microglia	NOUN
ajst-32481	80	8	produce	produce	VERB
ajst-32481	80	9	abundant	abundant	ADJ
ajst-32481	80	10	pro	pro	ADJ
ajst-32481	80	11	-	-	ADJ
ajst-32481	80	12	inflammatory	inflammatory	ADJ
ajst-32481	80	13	cytokines	cytokine	NOUN
ajst-32481	80	14	and	and	CCONJ
ajst-32481	80	15	facilitate	facilitate	VERB
ajst-32481	80	16	intercellular	intercellular	ADJ
ajst-32481	80	17	transmission	transmission	NOUN
ajst-32481	80	18	of	of	ADP
ajst-32481	80	19	misfolded	misfolde	VERB
ajst-32481	80	20	proteins	protein	NOUN
ajst-32481	80	21	(	(	PUNCT
ajst-32481	80	22	e.g.	e.g.	ADV
ajst-32481	80	23	,	,	PUNCT
ajst-32481	80	24	tau	tau	PROPN
ajst-32481	80	25	and	and	CCONJ
ajst-32481	80	26	aβ	aβ	NOUN
ajst-32481	80	27	)	)	PUNCT
ajst-32481	80	28	via	via	ADP
ajst-32481	80	29	exosomes	exosome	NOUN
ajst-32481	80	30	,	,	PUNCT
ajst-32481	80	31	accelerating	accelerate	VERB
ajst-32481	80	32	neurodegeneration	neurodegeneration	NOUN
ajst-32481	80	33	[	[	X
ajst-32481	80	34	20	20	NUM
ajst-32481	80	35	]	]	PUNCT
ajst-32481	80	36	.	.	PUNCT
ajst-32481	81	1	moreover	moreover	ADV
ajst-32481	81	2	,	,	PUNCT
ajst-32481	81	3	brains	brain	NOUN
ajst-32481	81	4	of	of	ADP
ajst-32481	81	5	ad	ad	NOUN
ajst-32481	81	6	patients	patient	NOUN
ajst-32481	81	7	exhibit	exhibit	VERB
ajst-32481	81	8	upregulated	upregulated	ADJ
ajst-32481	81	9	expression	expression	NOUN
ajst-32481	81	10	of	of	ADP
ajst-32481	81	11	inflammatory	inflammatory	ADJ
ajst-32481	81	12	cytokines	cytokine	NOUN
ajst-32481	81	13	and	and	CCONJ
ajst-32481	81	14	genes	gene	NOUN
ajst-32481	81	15	.	.	PUNCT
ajst-32481	82	1	for	for	ADP
ajst-32481	82	2	instance	instance	NOUN
ajst-32481	82	3	,	,	PUNCT
ajst-32481	82	4	interferon	interferon	ADJ
ajst-32481	82	5	-	-	PUNCT
ajst-32481	82	6	γ	γ	X
ajst-32481	82	7	(	(	PUNCT
ajst-32481	82	8	ifn	ifn	PROPN
ajst-32481	82	9	-	-	PUNCT
ajst-32481	82	10	γ	γ	NOUN
ajst-32481	82	11	)	)	PUNCT
ajst-32481	82	12	and	and	CCONJ
ajst-32481	82	13	tumor	tumor	NOUN
ajst-32481	82	14	necrosis	necrosis	NOUN
ajst-32481	82	15	factor	factor	NOUN
ajst-32481	82	16	-	-	PUNCT
ajst-32481	82	17	α	α	X
ajst-32481	82	18	(	(	PUNCT
ajst-32481	82	19	tnf	tnf	PROPN
ajst-32481	82	20	-	-	PUNCT
ajst-32481	82	21	α	α	NOUN
ajst-32481	82	22	)	)	PUNCT
ajst-32481	82	23	not	not	PART
ajst-32481	82	24	only	only	ADV
ajst-32481	82	25	exert	exert	VERB
ajst-32481	82	26	direct	direct	ADJ
ajst-32481	82	27	neurotoxicity	neurotoxicity	NOUN
ajst-32481	82	28	but	but	CCONJ
ajst-32481	82	29	also	also	ADV
ajst-32481	82	30	suppress	suppress	VERB
ajst-32481	82	31	insulin	insulin	NOUN
ajst-32481	82	32	-	-	PUNCT
ajst-32481	82	33	degrading	degrade	VERB
ajst-32481	82	34	enzyme	enzyme	NOUN
ajst-32481	82	35	,	,	PUNCT
ajst-32481	82	36	thereby	thereby	ADV
ajst-32481	82	37	hindering	hinder	VERB
ajst-32481	82	38	aβ	aβ	ADP
ajst-32481	82	39	clearance	clearance	NOUN
ajst-32481	82	40	and	and	CCONJ
ajst-32481	82	41	exacerbating	exacerbate	VERB
ajst-32481	82	42	deposition[22	deposition[22	PROPN
ajst-32481	82	43	]	]	PUNCT
ajst-32481	82	44	.	.	PUNCT
ajst-32481	83	1	in	in	ADP
ajst-32481	83	2	summary	summary	NOUN
ajst-32481	83	3	,	,	PUNCT
ajst-32481	83	4	sustained	sustain	VERB
ajst-32481	83	5	microglial	microglial	ADJ
ajst-32481	83	6	activation	activation	NOUN
ajst-32481	83	7	is	be	AUX
ajst-32481	83	8	a	a	DET
ajst-32481	83	9	key	key	ADJ
ajst-32481	83	10	“	"	PUNCT
ajst-32481	83	11	ignition	ignition	NOUN
ajst-32481	83	12	switch	switch	NOUN
ajst-32481	83	13	”	"	PUNCT
ajst-32481	83	14	for	for	ADP
ajst-32481	83	15	ad	ad	NOUN
ajst-32481	83	16	-	-	PUNCT
ajst-32481	83	17	related	relate	VERB
ajst-32481	83	18	neuroinflammation	neuroinflammation	NOUN
ajst-32481	83	19	.	.	PUNCT
ajst-32481	84	1	increasing	increase	VERB
ajst-32481	84	2	evidence	evidence	NOUN
ajst-32481	84	3	suggests	suggest	VERB
ajst-32481	84	4	that	that	SCONJ
ajst-32481	84	5	such	such	ADJ
ajst-32481	84	6	activation	activation	NOUN
ajst-32481	84	7	is	be	AUX
ajst-32481	84	8	not	not	PART
ajst-32481	84	9	solely	solely	ADV
ajst-32481	84	10	triggered	trigger	VERB
ajst-32481	84	11	by	by	ADP
ajst-32481	84	12	endogenous	endogenous	ADJ
ajst-32481	84	13	damage	damage	NOUN
ajst-32481	84	14	-	-	PUNCT
ajst-32481	84	15	associated	associate	VERB
ajst-32481	84	16	molecular	molecular	ADJ
ajst-32481	84	17	patterns	pattern	NOUN
ajst-32481	84	18	(	(	PUNCT
ajst-32481	84	19	damps	damps	VERB
ajst-32481	84	20	)	)	PUNCT
ajst-32481	84	21	within	within	ADP
ajst-32481	84	22	the	the	DET
ajst-32481	84	23	cns	cns	NOUN
ajst-32481	84	24	.	.	PUNCT
ajst-32481	85	1	gut	gut	NOUN
ajst-32481	85	2	microbiota	microbiota	NOUN
ajst-32481	85	3	can	can	AUX
ajst-32481	85	4	transmit	transmit	VERB
ajst-32481	85	5	exogenous	exogenous	ADJ
ajst-32481	85	6	signals	signal	NOUN
ajst-32481	85	7	to	to	ADP
ajst-32481	85	8	brain	brain	NOUN
ajst-32481	85	9	-	-	PUNCT
ajst-32481	85	10	resident	resident	NOUN
ajst-32481	85	11	microglia	microglia	NOUN
ajst-32481	85	12	through	through	ADP
ajst-32481	85	13	two	two	NUM
ajst-32481	85	14	parallel	parallel	ADJ
ajst-32481	85	15	pathways	pathway	NOUN
ajst-32481	85	16	:	:	PUNCT
ajst-32481	85	17	some	some	DET
ajst-32481	85	18	microbes	microbe	NOUN
ajst-32481	85	19	synthesize	synthesize	VERB
ajst-32481	85	20	or	or	CCONJ
ajst-32481	85	21	release	release	VERB
ajst-32481	85	22	bacterial	bacterial	ADJ
ajst-32481	85	23	amyloids	amyloid	NOUN
ajst-32481	85	24	structurally	structurally	ADV
ajst-32481	85	25	homologous	homologous	ADJ
ajst-32481	85	26	to	to	ADP
ajst-32481	85	27	aβ	aβ	VERB
ajst-32481	85	28	or	or	CCONJ
ajst-32481	85	29	tau	tau	PROPN
ajst-32481	85	30	,	,	PUNCT
ajst-32481	85	31	which	which	PRON
ajst-32481	85	32	cross	cross	NOUN
ajst-32481	85	33	-	-	NOUN
ajst-32481	85	34	seed	seed	NOUN
ajst-32481	85	35	with	with	ADP
ajst-32481	85	36	102	102	NUM
ajst-32481	85	37	host	host	NOUN
ajst-32481	85	38	proteins	protein	NOUN
ajst-32481	85	39	to	to	PART
ajst-32481	85	40	form	form	VERB
ajst-32481	85	41	highly	highly	ADV
ajst-32481	85	42	toxic	toxic	ADJ
ajst-32481	85	43	oligomers	oligomer	NOUN
ajst-32481	85	44	,	,	PUNCT
ajst-32481	85	45	inducing	induce	VERB
ajst-32481	85	46	chronic	chronic	ADJ
ajst-32481	85	47	inflammation	inflammation	NOUN
ajst-32481	85	48	.	.	PUNCT
ajst-32481	86	1	lipopolysaccharide	lipopolysaccharide	ADV
ajst-32481	86	2	(	(	PUNCT
ajst-32481	86	3	lps	lps	PROPN
ajst-32481	86	4	)	)	PUNCT
ajst-32481	86	5	,	,	PUNCT
ajst-32481	86	6	detected	detect	VERB
ajst-32481	86	7	in	in	ADP
ajst-32481	86	8	ad	ad	NOUN
ajst-32481	86	9	patients	patient	NOUN
ajst-32481	86	10	with	with	ADP
ajst-32481	86	11	increased	increase	VERB
ajst-32481	86	12	bbb	bbb	NOUN
ajst-32481	86	13	permeability	permeability	NOUN
ajst-32481	86	14	,	,	PUNCT
ajst-32481	86	15	can	can	AUX
ajst-32481	86	16	directly	directly	ADV
ajst-32481	86	17	bind	bind	VERB
ajst-32481	86	18	to	to	ADP
ajst-32481	86	19	the	the	DET
ajst-32481	86	20	tlr4cd14	tlr4cd14	NOUN
ajst-32481	86	21	complex	complex	NOUN
ajst-32481	86	22	on	on	ADP
ajst-32481	86	23	microglia	microglia	ADJ
ajst-32481	86	24	,	,	PUNCT
ajst-32481	86	25	amplifying	amplifying	ADJ
ajst-32481	86	26	nf	nf	NOUN
ajst-32481	86	27	-	-	PUNCT
ajst-32481	86	28	κb	κb	NOUN
ajst-32481	86	29	-	-	PUNCT
ajst-32481	86	30	mediated	mediate	VERB
ajst-32481	86	31	pro	pro	ADJ
ajst-32481	86	32	-	-	ADJ
ajst-32481	86	33	inflammatory	inflammatory	ADJ
ajst-32481	86	34	cascades	cascade	NOUN
ajst-32481	86	35	while	while	SCONJ
ajst-32481	86	36	inhibiting	inhibit	VERB
ajst-32481	86	37	aβ	aβ	NOUN
ajst-32481	86	38	phagocytosis	phagocytosis	NOUN
ajst-32481	86	39	[	[	X
ajst-32481	86	40	23	23	NUM
ajst-32481	86	41	]	]	PUNCT
ajst-32481	86	42	.	.	PUNCT
ajst-32481	87	1	these	these	DET
ajst-32481	87	2	bidirectional	bidirectional	ADJ
ajst-32481	87	3	signaling	signal	VERB
ajst-32481	87	4	pathways	pathway	NOUN
ajst-32481	87	5	between	between	ADP
ajst-32481	87	6	gut	gut	NOUN
ajst-32481	87	7	microbiota	microbiota	NOUN
ajst-32481	87	8	and	and	CCONJ
ajst-32481	87	9	microglia	microglia	NOUN
ajst-32481	87	10	constitute	constitute	VERB
ajst-32481	87	11	a	a	DET
ajst-32481	87	12	critical	critical	ADJ
ajst-32481	87	13	bridge	bridge	NOUN
ajst-32481	87	14	linking	link	VERB
ajst-32481	87	15	peripheral	peripheral	ADJ
ajst-32481	87	16	dysbiosis	dysbiosis	NOUN
ajst-32481	87	17	with	with	ADP
ajst-32481	87	18	central	central	ADJ
ajst-32481	87	19	ad	ad	NOUN
ajst-32481	87	20	pathology	pathology	NOUN
ajst-32481	87	21	,	,	PUNCT
ajst-32481	87	22	laying	lay	VERB
ajst-32481	87	23	the	the	DET
ajst-32481	87	24	foundation	foundation	NOUN
ajst-32481	87	25	for	for	ADP
ajst-32481	87	26	microbiome	microbiome	NOUN
ajst-32481	87	27	-	-	PUNCT
ajst-32481	87	28	based	base	VERB
ajst-32481	87	29	therapeutic	therapeutic	ADJ
ajst-32481	87	30	strategies	strategy	NOUN
ajst-32481	87	31	.	.	PUNCT
ajst-32481	88	1	4	4	X
ajst-32481	88	2	.	.	X
ajst-32481	88	3	microorganisms	microorganism	NOUN
ajst-32481	88	4	in	in	ADP
ajst-32481	88	5	the	the	DET
ajst-32481	88	6	pathological	pathological	ADJ
ajst-32481	88	7	progression	progression	NOUN
ajst-32481	88	8	of	of	ADP
ajst-32481	88	9	alzheimer	alzheimer	PROPN
ajst-32481	88	10	’s	’s	PART
ajst-32481	88	11	disease	disease	NOUN
ajst-32481	88	12	4.1	4.1	NUM
ajst-32481	88	13	characteristics	characteristic	NOUN
ajst-32481	88	14	and	and	CCONJ
ajst-32481	88	15	mechanisms	mechanism	NOUN
ajst-32481	88	16	of	of	ADP
ajst-32481	88	17	the	the	DET
ajst-32481	88	18	gut	gut	NOUN
ajst-32481	88	19	microbiome	microbiome	NOUN
ajst-32481	88	20	in	in	ADP
ajst-32481	88	21	alzheimer	alzheimer	PROPN
ajst-32481	88	22	’s	’s	PART
ajst-32481	88	23	disease	disease	NOUN
ajst-32481	88	24	in	in	ADP
ajst-32481	88	25	recent	recent	ADJ
ajst-32481	88	26	years	year	NOUN
ajst-32481	88	27	,	,	PUNCT
ajst-32481	88	28	research	research	NOUN
ajst-32481	88	29	on	on	ADP
ajst-32481	88	30	microbial	microbial	ADJ
ajst-32481	88	31	involvement	involvement	NOUN
ajst-32481	88	32	in	in	ADP
ajst-32481	88	33	ad	ad	NOUN
ajst-32481	88	34	pathogenesis	pathogenesis	NOUN
ajst-32481	88	35	has	have	AUX
ajst-32481	88	36	made	make	VERB
ajst-32481	88	37	significant	significant	ADJ
ajst-32481	88	38	progress	progress	NOUN
ajst-32481	88	39	.	.	PUNCT
ajst-32481	89	1	multiple	multiple	ADJ
ajst-32481	89	2	studies	study	NOUN
ajst-32481	89	3	have	have	AUX
ajst-32481	89	4	suggested	suggest	VERB
ajst-32481	89	5	that	that	SCONJ
ajst-32481	89	6	oral	oral	ADJ
ajst-32481	89	7	microbes	microbe	NOUN
ajst-32481	89	8	,	,	PUNCT
ajst-32481	89	9	gut	gut	NOUN
ajst-32481	89	10	microbiota	microbiota	NOUN
ajst-32481	89	11	,	,	PUNCT
ajst-32481	89	12	and	and	CCONJ
ajst-32481	89	13	certain	certain	ADJ
ajst-32481	89	14	pathogens	pathogen	NOUN
ajst-32481	89	15	may	may	AUX
ajst-32481	89	16	contribute	contribute	VERB
ajst-32481	89	17	to	to	ADP
ajst-32481	89	18	ad	ad	NOUN
ajst-32481	89	19	pathology	pathology	NOUN
ajst-32481	89	20	through	through	ADP
ajst-32481	89	21	diverse	diverse	ADJ
ajst-32481	89	22	mechanisms	mechanism	NOUN
ajst-32481	89	23	[	[	X
ajst-32481	89	24	24	24	NUM
ajst-32481	89	25	]	]	PUNCT
ajst-32481	89	26	.	.	PUNCT
ajst-32481	90	1	among	among	ADP
ajst-32481	90	2	these	these	PRON
ajst-32481	90	3	,	,	PUNCT
ajst-32481	90	4	the	the	DET
ajst-32481	90	5	gut	gut	NOUN
ajst-32481	90	6	-	-	PUNCT
ajst-32481	90	7	brain	brain	NOUN
ajst-32481	90	8	axis	axis	NOUN
ajst-32481	90	9	,	,	PUNCT
ajst-32481	90	10	highly	highly	ADV
ajst-32481	90	11	influenced	influence	VERB
ajst-32481	90	12	by	by	ADP
ajst-32481	90	13	the	the	DET
ajst-32481	90	14	gut	gut	NOUN
ajst-32481	90	15	microbiome	microbiome	NOUN
ajst-32481	90	16	,	,	PUNCT
ajst-32481	90	17	has	have	AUX
ajst-32481	90	18	yielded	yield	VERB
ajst-32481	90	19	breakthrough	breakthrough	NOUN
ajst-32481	90	20	findings	finding	NOUN
ajst-32481	90	21	.	.	PUNCT
ajst-32481	91	1	the	the	DET
ajst-32481	91	2	gut	gut	NOUN
ajst-32481	91	3	-	-	PUNCT
ajst-32481	91	4	brain	brain	NOUN
ajst-32481	91	5	axis	axis	NOUN
ajst-32481	91	6	plays	play	VERB
ajst-32481	91	7	a	a	DET
ajst-32481	91	8	crucial	crucial	ADJ
ajst-32481	91	9	regulatory	regulatory	ADJ
ajst-32481	91	10	role	role	NOUN
ajst-32481	91	11	in	in	ADP
ajst-32481	91	12	ad	ad	NOUN
ajst-32481	91	13	pathogenesis	pathogenesis	NOUN
ajst-32481	91	14	.	.	PUNCT
ajst-32481	92	1	metagenomic	metagenomic	ADJ
ajst-32481	92	2	studies	study	NOUN
ajst-32481	92	3	consistently	consistently	ADV
ajst-32481	92	4	reveal	reveal	VERB
ajst-32481	92	5	marked	mark	VERB
ajst-32481	92	6	alterations	alteration	NOUN
ajst-32481	92	7	in	in	ADP
ajst-32481	92	8	gut	gut	NOUN
ajst-32481	92	9	microbiota	microbiota	NOUN
ajst-32481	92	10	composition	composition	NOUN
ajst-32481	92	11	in	in	ADP
ajst-32481	92	12	ad	ad	NOUN
ajst-32481	92	13	patients	patient	NOUN
ajst-32481	92	14	,	,	PUNCT
ajst-32481	92	15	particularly	particularly	ADV
ajst-32481	92	16	reduced	reduce	VERB
ajst-32481	92	17	microbial	microbial	ADJ
ajst-32481	92	18	abundance	abundance	NOUN
ajst-32481	93	1	[	[	X
ajst-32481	93	2	25	25	NUM
ajst-32481	93	3	]	]	PUNCT
ajst-32481	93	4	.	.	PUNCT
ajst-32481	94	1	additionally	additionally	ADV
ajst-32481	94	2	,	,	PUNCT
ajst-32481	94	3	the	the	DET
ajst-32481	94	4	levels	level	NOUN
ajst-32481	94	5	of	of	ADP
ajst-32481	94	6	microbiota	microbiota	NOUN
ajst-32481	94	7	-	-	PUNCT
ajst-32481	94	8	derived	derive	VERB
ajst-32481	94	9	metabolites	metabolite	NOUN
ajst-32481	94	10	,	,	PUNCT
ajst-32481	94	11	such	such	ADJ
ajst-32481	94	12	as	as	ADP
ajst-32481	94	13	scfas	scfas	NOUN
ajst-32481	94	14	,	,	PUNCT
ajst-32481	94	15	are	be	AUX
ajst-32481	94	16	significantly	significantly	ADV
ajst-32481	94	17	decreased	decrease	VERB
ajst-32481	94	18	,	,	PUNCT
ajst-32481	94	19	potentially	potentially	ADV
ajst-32481	94	20	aggravating	aggravate	VERB
ajst-32481	94	21	ad	ad	NOUN
ajst-32481	94	22	pathology	pathology	NOUN
ajst-32481	94	23	through	through	ADP
ajst-32481	94	24	multiple	multiple	ADJ
ajst-32481	94	25	mechanisms	mechanism	NOUN
ajst-32481	94	26	.	.	PUNCT
ajst-32481	95	1	these	these	PRON
ajst-32481	95	2	include	include	VERB
ajst-32481	95	3	enhancing	enhance	VERB
ajst-32481	95	4	aβ	aβ	PRON
ajst-32481	95	5	plaque	plaque	NOUN
ajst-32481	95	6	deposition	deposition	NOUN
ajst-32481	95	7	,	,	PUNCT
ajst-32481	95	8	inducing	induce	VERB
ajst-32481	95	9	metabolic	metabolic	ADJ
ajst-32481	95	10	dysfunction	dysfunction	NOUN
ajst-32481	95	11	,	,	PUNCT
ajst-32481	95	12	and	and	CCONJ
ajst-32481	95	13	dysregulating	dysregulate	VERB
ajst-32481	95	14	microglial	microglial	ADJ
ajst-32481	95	15	activity	activity	NOUN
ajst-32481	95	16	.	.	PUNCT
ajst-32481	96	1	these	these	DET
ajst-32481	96	2	findings	finding	NOUN
ajst-32481	96	3	provide	provide	VERB
ajst-32481	96	4	cutting	cutting	NOUN
ajst-32481	96	5	-	-	PUNCT
ajst-32481	96	6	edge	edge	NOUN
ajst-32481	96	7	theoretical	theoretical	ADJ
ajst-32481	96	8	evidence	evidence	NOUN
ajst-32481	96	9	for	for	ADP
ajst-32481	96	10	understanding	understand	VERB
ajst-32481	96	11	the	the	DET
ajst-32481	96	12	role	role	NOUN
ajst-32481	96	13	of	of	ADP
ajst-32481	96	14	the	the	DET
ajst-32481	96	15	gut	gut	NOUN
ajst-32481	96	16	microbiome	microbiome	NOUN
ajst-32481	96	17	in	in	ADP
ajst-32481	96	18	ad	ad	NOUN
ajst-32481	96	19	.	.	PUNCT
ajst-32481	97	1	4.2	4.2	NUM
ajst-32481	97	2	the	the	DET
ajst-32481	97	3	bidirectional	bidirectional	ADJ
ajst-32481	97	4	gut	gut	NOUN
ajst-32481	97	5	-	-	PUNCT
ajst-32481	97	6	brain	brain	NOUN
ajst-32481	97	7	axis	axis	NOUN
ajst-32481	97	8	the	the	DET
ajst-32481	97	9	concept	concept	NOUN
ajst-32481	97	10	of	of	ADP
ajst-32481	97	11	the	the	DET
ajst-32481	97	12	gut	gut	NOUN
ajst-32481	97	13	-	-	PUNCT
ajst-32481	97	14	brain	brain	NOUN
ajst-32481	97	15	axis	axis	NOUN
ajst-32481	97	16	was	be	AUX
ajst-32481	97	17	first	first	ADV
ajst-32481	97	18	introduced	introduce	VERB
ajst-32481	97	19	in	in	ADP
ajst-32481	97	20	2004	2004	NUM
ajst-32481	97	21	by	by	ADP
ajst-32481	97	22	sudo	sudo	NOUN
ajst-32481	97	23	and	and	CCONJ
ajst-32481	97	24	colleagues	colleague	NOUN
ajst-32481	97	25	,	,	PUNCT
ajst-32481	97	26	based	base	VERB
ajst-32481	97	27	on	on	ADP
ajst-32481	97	28	germ	germ	NOUN
ajst-32481	97	29	-	-	PUNCT
ajst-32481	97	30	free	free	ADJ
ajst-32481	97	31	mouse	mouse	NOUN
ajst-32481	97	32	models[26	models[26	NOUN
ajst-32481	97	33	]	]	PUNCT
ajst-32481	97	34	.	.	PUNCT
ajst-32481	98	1	it	it	PRON
ajst-32481	98	2	was	be	AUX
ajst-32481	98	3	defined	define	VERB
ajst-32481	98	4	as	as	ADP
ajst-32481	98	5	a	a	DET
ajst-32481	98	6	dynamic	dynamic	ADJ
ajst-32481	98	7	bidirectional	bidirectional	NOUN
ajst-32481	98	8	signaling	signal	VERB
ajst-32481	98	9	pathway	pathway	NOUN
ajst-32481	98	10	connecting	connect	VERB
ajst-32481	98	11	the	the	DET
ajst-32481	98	12	intestine	intestine	NOUN
ajst-32481	98	13	and	and	CCONJ
ajst-32481	98	14	the	the	DET
ajst-32481	98	15	central	central	ADJ
ajst-32481	98	16	nervous	nervous	ADJ
ajst-32481	98	17	system	system	NOUN
ajst-32481	98	18	(	(	PUNCT
ajst-32481	98	19	cns	cns	NOUN
ajst-32481	98	20	)	)	PUNCT
ajst-32481	98	21	via	via	ADP
ajst-32481	98	22	neural	neural	ADJ
ajst-32481	98	23	,	,	PUNCT
ajst-32481	98	24	endocrine	endocrine	NOUN
ajst-32481	98	25	,	,	PUNCT
ajst-32481	98	26	and	and	CCONJ
ajst-32481	98	27	immune	immune	ADJ
ajst-32481	98	28	routes	route	NOUN
ajst-32481	98	29	[	[	X
ajst-32481	98	30	27	27	NUM
ajst-32481	98	31	]	]	PUNCT
ajst-32481	98	32	.	.	PUNCT
ajst-32481	99	1	with	with	ADP
ajst-32481	99	2	advancing	advance	VERB
ajst-32481	99	3	research	research	NOUN
ajst-32481	99	4	,	,	PUNCT
ajst-32481	99	5	this	this	DET
ajst-32481	99	6	concept	concept	NOUN
ajst-32481	99	7	evolved	evolve	VERB
ajst-32481	99	8	into	into	ADP
ajst-32481	99	9	the	the	DET
ajst-32481	99	10	“	"	PUNCT
ajst-32481	99	11	gut	gut	NOUN
ajst-32481	99	12	-	-	PUNCT
ajst-32481	99	13	microbiota	microbiota	NOUN
ajst-32481	99	14	-	-	PUNCT
ajst-32481	99	15	brain	brain	NOUN
ajst-32481	99	16	axis	axis	NOUN
ajst-32481	99	17	,	,	PUNCT
ajst-32481	99	18	”	"	PUNCT
ajst-32481	99	19	which	which	PRON
ajst-32481	99	20	is	be	AUX
ajst-32481	99	21	now	now	ADV
ajst-32481	99	22	recognized	recognize	VERB
ajst-32481	99	23	to	to	PART
ajst-32481	99	24	participate	participate	VERB
ajst-32481	99	25	in	in	ADP
ajst-32481	99	26	the	the	DET
ajst-32481	99	27	pathophysiology	pathophysiology	NOUN
ajst-32481	99	28	of	of	ADP
ajst-32481	99	29	neurodegenerative	neurodegenerative	ADJ
ajst-32481	99	30	diseases	disease	NOUN
ajst-32481	99	31	through	through	ADP
ajst-32481	99	32	neural	neural	ADJ
ajst-32481	99	33	,	,	PUNCT
ajst-32481	99	34	endocrine	endocrine	NOUN
ajst-32481	99	35	,	,	PUNCT
ajst-32481	99	36	and	and	CCONJ
ajst-32481	99	37	immune	immune	ADJ
ajst-32481	99	38	dimensions	dimension	NOUN
ajst-32481	99	39	.	.	PUNCT
ajst-32481	100	1	the	the	DET
ajst-32481	100	2	vagus	vagus	NOUN
ajst-32481	100	3	nerve	nerve	NOUN
ajst-32481	100	4	is	be	AUX
ajst-32481	100	5	the	the	DET
ajst-32481	100	6	primary	primary	ADJ
ajst-32481	100	7	neural	neural	ADJ
ajst-32481	100	8	pathway	pathway	NOUN
ajst-32481	100	9	linking	link	VERB
ajst-32481	100	10	the	the	DET
ajst-32481	100	11	gut	gut	NOUN
ajst-32481	100	12	to	to	ADP
ajst-32481	100	13	the	the	DET
ajst-32481	100	14	cns	cns	NOUN
ajst-32481	100	15	,	,	PUNCT
ajst-32481	100	16	and	and	CCONJ
ajst-32481	100	17	its	its	PRON
ajst-32481	100	18	signaling	signal	VERB
ajst-32481	100	19	mechanisms	mechanism	NOUN
ajst-32481	100	20	have	have	AUX
ajst-32481	100	21	been	be	AUX
ajst-32481	100	22	extensively	extensively	ADV
ajst-32481	100	23	studied	study	VERB
ajst-32481	100	24	.	.	PUNCT
ajst-32481	101	1	microbial	microbial	ADJ
ajst-32481	101	2	metabolites	metabolite	NOUN
ajst-32481	101	3	can	can	AUX
ajst-32481	101	4	specifically	specifically	ADV
ajst-32481	101	5	activate	activate	VERB
ajst-32481	101	6	enteroendocrine	enteroendocrine	ADJ
ajst-32481	101	7	cells	cell	NOUN
ajst-32481	101	8	or	or	CCONJ
ajst-32481	101	9	enterochromaffin	enterochromaffin	NOUN
ajst-32481	101	10	cells	cell	NOUN
ajst-32481	101	11	in	in	ADP
ajst-32481	101	12	the	the	DET
ajst-32481	101	13	gut	gut	NOUN
ajst-32481	101	14	[	[	X
ajst-32481	101	15	28	28	NUM
ajst-32481	101	16	]	]	PUNCT
ajst-32481	101	17	,	,	PUNCT
ajst-32481	101	18	stimulating	stimulate	VERB
ajst-32481	101	19	the	the	DET
ajst-32481	101	20	release	release	NOUN
ajst-32481	101	21	of	of	ADP
ajst-32481	101	22	neurotransmitters	neurotransmitter	NOUN
ajst-32481	101	23	such	such	ADJ
ajst-32481	101	24	as	as	ADP
ajst-32481	101	25	cholecystokinin	cholecystokinin	NOUN
ajst-32481	101	26	,	,	PUNCT
ajst-32481	101	27	which	which	PRON
ajst-32481	101	28	in	in	ADP
ajst-32481	101	29	turn	turn	NOUN
ajst-32481	101	30	activate	activate	VERB
ajst-32481	101	31	vagal	vagal	ADJ
ajst-32481	101	32	afferent	afferent	ADJ
ajst-32481	101	33	fibers	fiber	NOUN
ajst-32481	101	34	[	[	X
ajst-32481	101	35	29	29	NUM
ajst-32481	101	36	]	]	PUNCT
ajst-32481	101	37	.	.	PUNCT
ajst-32481	102	1	these	these	DET
ajst-32481	102	2	signals	signal	NOUN
ajst-32481	102	3	are	be	AUX
ajst-32481	102	4	relayed	relay	VERB
ajst-32481	102	5	via	via	ADP
ajst-32481	102	6	the	the	DET
ajst-32481	102	7	nucleus	nucleus	ADJ
ajst-32481	102	8	tractus	tractus	NOUN
ajst-32481	102	9	solitarius	solitarius	NOUN
ajst-32481	102	10	to	to	ADP
ajst-32481	102	11	the	the	DET
ajst-32481	102	12	limbic	limbic	ADJ
ajst-32481	102	13	system	system	NOUN
ajst-32481	102	14	,	,	PUNCT
ajst-32481	102	15	ultimately	ultimately	ADV
ajst-32481	102	16	influencing	influence	VERB
ajst-32481	102	17	mood	mood	NOUN
ajst-32481	102	18	and	and	CCONJ
ajst-32481	102	19	cognitive	cognitive	ADJ
ajst-32481	102	20	functions	function	NOUN
ajst-32481	102	21	[	[	X
ajst-32481	102	22	30	30	NUM
ajst-32481	102	23	]	]	PUNCT
ajst-32481	102	24	.	.	PUNCT
ajst-32481	103	1	microbe	microbe	NOUN
ajst-32481	103	2	-	-	PUNCT
ajst-32481	103	3	host	host	NOUN
ajst-32481	103	4	co	co	NOUN
ajst-32481	103	5	-	-	NOUN
ajst-32481	103	6	metabolites	metabolite	NOUN
ajst-32481	103	7	also	also	ADV
ajst-32481	103	8	play	play	VERB
ajst-32481	103	9	a	a	DET
ajst-32481	103	10	central	central	ADJ
ajst-32481	103	11	role	role	NOUN
ajst-32481	103	12	in	in	ADP
ajst-32481	103	13	endocrine	endocrine	ADJ
ajst-32481	103	14	signaling	signaling	NOUN
ajst-32481	103	15	.	.	PUNCT
ajst-32481	104	1	for	for	ADP
ajst-32481	104	2	instance	instance	NOUN
ajst-32481	104	3	,	,	PUNCT
ajst-32481	104	4	scfas	scfas	PROPN
ajst-32481	104	5	can	can	AUX
ajst-32481	104	6	cross	cross	VERB
ajst-32481	104	7	the	the	DET
ajst-32481	104	8	bbb	bbb	NOUN
ajst-32481	104	9	and	and	CCONJ
ajst-32481	104	10	upregulate	upregulate	VERB
ajst-32481	104	11	brain	brain	NOUN
ajst-32481	104	12	-	-	PUNCT
ajst-32481	104	13	derived	derive	VERB
ajst-32481	104	14	neurotrophic	neurotrophic	ADJ
ajst-32481	104	15	factor	factor	NOUN
ajst-32481	104	16	(	(	PUNCT
ajst-32481	104	17	bdnf	bdnf	PROPN
ajst-32481	104	18	)	)	PUNCT
ajst-32481	105	1	[	[	X
ajst-32481	105	2	31	31	NUM
ajst-32481	105	3	]	]	PUNCT
ajst-32481	105	4	.	.	PUNCT
ajst-32481	106	1	similarly	similarly	ADV
ajst-32481	106	2	,	,	PUNCT
ajst-32481	106	3	tryptophan	tryptophan	NOUN
ajst-32481	106	4	metabolism	metabolism	NOUN
ajst-32481	106	5	,	,	PUNCT
ajst-32481	106	6	which	which	PRON
ajst-32481	106	7	is	be	AUX
ajst-32481	106	8	strongly	strongly	ADV
ajst-32481	106	9	influenced	influence	VERB
ajst-32481	106	10	by	by	ADP
ajst-32481	106	11	gut	gut	NOUN
ajst-32481	106	12	microbiota	microbiota	NOUN
ajst-32481	106	13	,	,	PUNCT
ajst-32481	106	14	produces	produce	VERB
ajst-32481	106	15	indole	indole	ADJ
ajst-32481	106	16	derivatives	derivative	NOUN
ajst-32481	106	17	and	and	CCONJ
ajst-32481	106	18	serotonin	serotonin	VERB
ajst-32481	106	19	precursors	precursor	NOUN
ajst-32481	106	20	that	that	PRON
ajst-32481	106	21	act	act	VERB
ajst-32481	106	22	on	on	ADP
ajst-32481	106	23	the	the	DET
ajst-32481	106	24	cns	cns	NOUN
ajst-32481	106	25	via	via	ADP
ajst-32481	106	26	the	the	DET
ajst-32481	106	27	portal	portal	ADJ
ajst-32481	106	28	circulation	circulation	NOUN
ajst-32481	106	29	,	,	PUNCT
ajst-32481	106	30	thereby	thereby	ADV
ajst-32481	106	31	modulating	modulate	VERB
ajst-32481	106	32	neuronal	neuronal	ADJ
ajst-32481	106	33	function	function	NOUN
ajst-32481	106	34	[	[	X
ajst-32481	106	35	32	32	NUM
ajst-32481	106	36	]	]	PUNCT
ajst-32481	106	37	.	.	PUNCT
ajst-32481	107	1	the	the	DET
ajst-32481	107	2	immune	immune	NOUN
ajst-32481	107	3	-	-	PUNCT
ajst-32481	107	4	mediated	mediate	VERB
ajst-32481	107	5	link	link	NOUN
ajst-32481	107	6	between	between	ADP
ajst-32481	107	7	the	the	DET
ajst-32481	107	8	gut	gut	NOUN
ajst-32481	107	9	microbiota	microbiota	NOUN
ajst-32481	107	10	and	and	CCONJ
ajst-32481	107	11	cns	cns	NOUN
ajst-32481	107	12	involves	involve	VERB
ajst-32481	107	13	a	a	DET
ajst-32481	107	14	cascade	cascade	NOUN
ajst-32481	107	15	of	of	ADP
ajst-32481	107	16	responses	response	NOUN
ajst-32481	107	17	.	.	PUNCT
ajst-32481	108	1	gut	gut	NOUN
ajst-32481	108	2	dysbiosis	dysbiosis	NOUN
ajst-32481	108	3	disrupts	disrupt	VERB
ajst-32481	108	4	intestinal	intestinal	ADJ
ajst-32481	108	5	barrier	barrier	NOUN
ajst-32481	108	6	integrity	integrity	NOUN
ajst-32481	108	7	,	,	PUNCT
ajst-32481	108	8	allowing	allow	VERB
ajst-32481	108	9	lps	lps	PROPN
ajst-32481	108	10	to	to	PART
ajst-32481	108	11	enter	enter	VERB
ajst-32481	108	12	circulation[33	circulation[33	NOUN
ajst-32481	108	13	]	]	PUNCT
ajst-32481	108	14	.	.	PUNCT
ajst-32481	109	1	lps	lps	PROPN
ajst-32481	109	2	subsequently	subsequently	ADV
ajst-32481	109	3	activates	activate	VERB
ajst-32481	109	4	peripheral	peripheral	ADJ
ajst-32481	109	5	immune	immune	ADJ
ajst-32481	109	6	cells[33	cells[33	NOUN
ajst-32481	109	7	]	]	PUNCT
ajst-32481	109	8	,	,	PUNCT
ajst-32481	109	9	inducing	induce	VERB
ajst-32481	109	10	the	the	DET
ajst-32481	109	11	release	release	NOUN
ajst-32481	109	12	of	of	ADP
ajst-32481	109	13	pro	pro	ADJ
ajst-32481	109	14	-	-	ADJ
ajst-32481	109	15	inflammatory	inflammatory	ADJ
ajst-32481	109	16	cytokines[34	cytokines[34	NOUN
ajst-32481	109	17	]	]	PUNCT
ajst-32481	109	18	,	,	PUNCT
ajst-32481	109	19	which	which	PRON
ajst-32481	109	20	in	in	ADP
ajst-32481	109	21	turn	turn	NOUN
ajst-32481	109	22	influence	influence	NOUN
ajst-32481	109	23	cns	cns	NOUN
ajst-32481	109	24	function	function	NOUN
ajst-32481	109	25	through	through	ADP
ajst-32481	109	26	multiple	multiple	ADJ
ajst-32481	109	27	routes	route	NOUN
ajst-32481	109	28	.	.	PUNCT
ajst-32481	110	1	animal	animal	NOUN
ajst-32481	110	2	studies	study	NOUN
ajst-32481	110	3	confirm	confirm	VERB
ajst-32481	110	4	that	that	SCONJ
ajst-32481	110	5	antibiotic	antibiotic	NOUN
ajst-32481	110	6	-	-	PUNCT
ajst-32481	110	7	induced	induce	VERB
ajst-32481	110	8	dysbiosis	dysbiosis	NOUN
ajst-32481	110	9	significantly	significantly	ADV
ajst-32481	110	10	suppresses	suppress	VERB
ajst-32481	110	11	hippocampal	hippocampal	ADJ
ajst-32481	110	12	neurogenesis	neurogenesis	NOUN
ajst-32481	110	13	,	,	PUNCT
ajst-32481	110	14	whereas	whereas	SCONJ
ajst-32481	110	15	microbiota	microbiota	NOUN
ajst-32481	110	16	restoration	restoration	NOUN
ajst-32481	110	17	or	or	CCONJ
ajst-32481	110	18	anti	anti	ADJ
ajst-32481	110	19	-	-	ADJ
ajst-32481	110	20	inflammatory	inflammatory	ADJ
ajst-32481	110	21	treatments	treatment	NOUN
ajst-32481	110	22	can	can	AUX
ajst-32481	110	23	reverse	reverse	VERB
ajst-32481	110	24	these	these	DET
ajst-32481	110	25	pathological	pathological	ADJ
ajst-32481	110	26	effects[35	effects[35	NOUN
ajst-32481	110	27	]	]	PUNCT
ajst-32481	110	28	.	.	PUNCT
ajst-32481	111	1	despite	despite	SCONJ
ajst-32481	111	2	progress	progress	NOUN
ajst-32481	111	3	,	,	PUNCT
ajst-32481	111	4	several	several	ADJ
ajst-32481	111	5	key	key	ADJ
ajst-32481	111	6	scientific	scientific	ADJ
ajst-32481	111	7	questions	question	NOUN
ajst-32481	111	8	remain	remain	VERB
ajst-32481	111	9	unresolved	unresolved	ADJ
ajst-32481	111	10	.	.	PUNCT
ajst-32481	112	1	first	first	ADV
ajst-32481	112	2	,	,	PUNCT
ajst-32481	112	3	some	some	DET
ajst-32481	112	4	microbial	microbial	ADJ
ajst-32481	112	5	species	specie	NOUN
ajst-32481	112	6	detected	detect	VERB
ajst-32481	112	7	in	in	ADP
ajst-32481	112	8	ad	ad	NOUN
ajst-32481	112	9	patients	patient	NOUN
ajst-32481	112	10	are	be	AUX
ajst-32481	112	11	also	also	ADV
ajst-32481	112	12	present	present	ADJ
ajst-32481	112	13	in	in	ADP
ajst-32481	112	14	healthy	healthy	ADJ
ajst-32481	112	15	individuals[36	individuals[36	NOUN
ajst-32481	112	16	]	]	PUNCT
ajst-32481	112	17	.	.	PUNCT
ajst-32481	113	1	thus	thus	ADV
ajst-32481	113	2	,	,	PUNCT
ajst-32481	113	3	establishing	establish	VERB
ajst-32481	113	4	gut	gut	NOUN
ajst-32481	113	5	microbes	microbe	NOUN
ajst-32481	113	6	as	as	SCONJ
ajst-32481	113	7	reliable	reliable	ADJ
ajst-32481	113	8	ad	ad	NOUN
ajst-32481	113	9	biomarkers	biomarker	NOUN
ajst-32481	113	10	requires	require	VERB
ajst-32481	113	11	stricter	strict	ADJ
ajst-32481	113	12	validation	validation	NOUN
ajst-32481	113	13	.	.	PUNCT
ajst-32481	114	1	for	for	ADP
ajst-32481	114	2	example	example	NOUN
ajst-32481	114	3	,	,	PUNCT
ajst-32481	114	4	reduced	reduced	ADJ
ajst-32481	114	5	abundance	abundance	NOUN
ajst-32481	114	6	of	of	ADP
ajst-32481	114	7	faecalibacterium	faecalibacterium	NOUN
ajst-32481	114	8	prausnitzii	prausnitzii	NOUN
ajst-32481	114	9	has	have	AUX
ajst-32481	114	10	been	be	AUX
ajst-32481	114	11	positively	positively	ADV
ajst-32481	114	12	correlated	correlate	VERB
ajst-32481	114	13	with	with	ADP
ajst-32481	114	14	aβ	aβ	ADP
ajst-32481	114	15	deposition	deposition	NOUN
ajst-32481	114	16	,	,	PUNCT
ajst-32481	114	17	but	but	CCONJ
ajst-32481	114	18	longitudinal	longitudinal	ADJ
ajst-32481	114	19	studies	study	NOUN
ajst-32481	114	20	are	be	AUX
ajst-32481	114	21	needed	need	VERB
ajst-32481	114	22	to	to	PART
ajst-32481	114	23	confirm	confirm	VERB
ajst-32481	114	24	its	its	PRON
ajst-32481	114	25	temporal	temporal	ADJ
ajst-32481	114	26	stability[37	stability[37	NOUN
ajst-32481	114	27	]	]	PUNCT
ajst-32481	114	28	.	.	PUNCT
ajst-32481	115	1	second	second	ADJ
ajst-32481	115	2	,	,	PUNCT
ajst-32481	115	3	gut	gut	NOUN
ajst-32481	115	4	microbiota	microbiota	NOUN
ajst-32481	115	5	composition	composition	NOUN
ajst-32481	115	6	varies	vary	VERB
ajst-32481	115	7	103	103	NUM
ajst-32481	115	8	significantly	significantly	ADV
ajst-32481	115	9	with	with	ADP
ajst-32481	115	10	diet	diet	PROPN
ajst-32481	115	11	,	,	PUNCT
ajst-32481	115	12	lifestyle	lifestyle	NOUN
ajst-32481	115	13	,	,	PUNCT
ajst-32481	115	14	and	and	CCONJ
ajst-32481	115	15	medication	medication	NOUN
ajst-32481	115	16	,	,	PUNCT
ajst-32481	115	17	introducing	introduce	VERB
ajst-32481	115	18	high	high	ADJ
ajst-32481	115	19	individual	individual	ADJ
ajst-32481	115	20	heterogeneity	heterogeneity	NOUN
ajst-32481	115	21	and	and	CCONJ
ajst-32481	115	22	complicating	complicate	VERB
ajst-32481	115	23	study	study	NOUN
ajst-32481	115	24	design	design	NOUN
ajst-32481	115	25	and	and	CCONJ
ajst-32481	115	26	interpretation	interpretation	NOUN
ajst-32481	115	27	.	.	PUNCT
ajst-32481	116	1	nevertheless	nevertheless	ADV
ajst-32481	116	2	,	,	PUNCT
ajst-32481	116	3	the	the	DET
ajst-32481	116	4	potential	potential	ADJ
ajst-32481	116	5	roles	role	NOUN
ajst-32481	116	6	of	of	ADP
ajst-32481	116	7	gut	gut	NOUN
ajst-32481	116	8	microbiota	microbiota	NOUN
ajst-32481	116	9	in	in	ADP
ajst-32481	116	10	ad	ad	NOUN
ajst-32481	116	11	pathogenesis	pathogenesis	NOUN
ajst-32481	116	12	offer	offer	VERB
ajst-32481	116	13	promising	promise	VERB
ajst-32481	116	14	therapeutic	therapeutic	ADJ
ajst-32481	116	15	perspectives	perspective	NOUN
ajst-32481	116	16	.	.	PUNCT
ajst-32481	117	1	clinical	clinical	ADJ
ajst-32481	117	2	evidence	evidence	NOUN
ajst-32481	117	3	suggests	suggest	VERB
ajst-32481	117	4	that	that	SCONJ
ajst-32481	117	5	microbiota	microbiota	NOUN
ajst-32481	117	6	-	-	PUNCT
ajst-32481	117	7	targeted	target	VERB
ajst-32481	117	8	interventions	intervention	NOUN
ajst-32481	117	9	,	,	PUNCT
ajst-32481	117	10	such	such	ADJ
ajst-32481	117	11	as	as	ADP
ajst-32481	117	12	probiotics	probiotic	NOUN
ajst-32481	117	13	,	,	PUNCT
ajst-32481	117	14	can	can	AUX
ajst-32481	117	15	effectively	effectively	ADV
ajst-32481	117	16	reshape	reshape	VERB
ajst-32481	117	17	gut	gut	NOUN
ajst-32481	117	18	microbial	microbial	ADJ
ajst-32481	117	19	structure	structure	NOUN
ajst-32481	117	20	,	,	PUNCT
ajst-32481	117	21	improve	improve	VERB
ajst-32481	117	22	cognitive	cognitive	ADJ
ajst-32481	117	23	function	function	NOUN
ajst-32481	117	24	,	,	PUNCT
ajst-32481	117	25	and	and	CCONJ
ajst-32481	117	26	alleviate	alleviate	VERB
ajst-32481	117	27	neuroinflammation	neuroinflammation	NOUN
ajst-32481	117	28	in	in	ADP
ajst-32481	117	29	ad	ad	NOUN
ajst-32481	117	30	patients[24	patients[24	NOUN
ajst-32481	117	31	]	]	PUNCT
ajst-32481	117	32	.	.	PUNCT
ajst-32481	118	1	with	with	ADP
ajst-32481	118	2	continued	continued	ADJ
ajst-32481	118	3	research	research	NOUN
ajst-32481	118	4	,	,	PUNCT
ajst-32481	118	5	future	future	ADJ
ajst-32481	118	6	studies	study	NOUN
ajst-32481	118	7	may	may	AUX
ajst-32481	118	8	further	far	ADV
ajst-32481	118	9	uncover	uncover	VERB
ajst-32481	118	10	the	the	DET
ajst-32481	118	11	complex	complex	ADJ
ajst-32481	118	12	interplay	interplay	NOUN
ajst-32481	118	13	between	between	ADP
ajst-32481	118	14	gut	gut	NOUN
ajst-32481	118	15	microbiota	microbiota	NOUN
ajst-32481	118	16	and	and	CCONJ
ajst-32481	118	17	ad	ad	NOUN
ajst-32481	118	18	pathology	pathology	NOUN
ajst-32481	118	19	,	,	PUNCT
ajst-32481	118	20	leading	lead	VERB
ajst-32481	118	21	to	to	ADP
ajst-32481	118	22	microbiome	microbiome	NOUN
ajst-32481	118	23	-	-	PUNCT
ajst-32481	118	24	based	base	VERB
ajst-32481	118	25	diagnostic	diagnostic	ADJ
ajst-32481	118	26	tools	tool	NOUN
ajst-32481	118	27	and	and	CCONJ
ajst-32481	118	28	therapeutic	therapeutic	ADJ
ajst-32481	118	29	strategies	strategy	NOUN
ajst-32481	118	30	.	.	PUNCT
ajst-32481	119	1	5	5	X
ajst-32481	119	2	.	.	X
ajst-32481	119	3	challenges	challenge	NOUN
ajst-32481	119	4	and	and	CCONJ
ajst-32481	119	5	perspectives	perspective	NOUN
ajst-32481	119	6	this	this	DET
ajst-32481	119	7	review	review	NOUN
ajst-32481	119	8	has	have	AUX
ajst-32481	119	9	systematically	systematically	ADV
ajst-32481	119	10	summarized	summarize	VERB
ajst-32481	119	11	the	the	DET
ajst-32481	119	12	widely	widely	ADV
ajst-32481	119	13	recognized	recognize	VERB
ajst-32481	119	14	pathological	pathological	ADJ
ajst-32481	119	15	mechanisms	mechanism	NOUN
ajst-32481	119	16	of	of	ADP
ajst-32481	119	17	ad	ad	NOUN
ajst-32481	119	18	and	and	CCONJ
ajst-32481	119	19	the	the	DET
ajst-32481	119	20	multidimensional	multidimensional	ADJ
ajst-32481	119	21	roles	role	NOUN
ajst-32481	119	22	of	of	ADP
ajst-32481	119	23	the	the	DET
ajst-32481	119	24	gut	gut	NOUN
ajst-32481	119	25	microbiome	microbiome	NOUN
ajst-32481	119	26	in	in	ADP
ajst-32481	119	27	modulating	modulate	VERB
ajst-32481	119	28	ad	ad	NOUN
ajst-32481	119	29	pathophysiology	pathophysiology	NOUN
ajst-32481	119	30	through	through	ADP
ajst-32481	119	31	the	the	DET
ajst-32481	119	32	microbiota	microbiota	NOUN
ajst-32481	119	33	-	-	PUNCT
ajst-32481	119	34	gut	gut	NOUN
ajst-32481	119	35	-	-	PUNCT
ajst-32481	119	36	brain	brain	NOUN
ajst-32481	119	37	axis	axis	NOUN
ajst-32481	119	38	.	.	PUNCT
ajst-32481	120	1	it	it	PRON
ajst-32481	120	2	has	have	AUX
ajst-32481	120	3	also	also	ADV
ajst-32481	120	4	explored	explore	VERB
ajst-32481	120	5	the	the	DET
ajst-32481	120	6	therapeutic	therapeutic	ADJ
ajst-32481	120	7	potential	potential	NOUN
ajst-32481	120	8	of	of	ADP
ajst-32481	120	9	microbiotabased	microbiotabase	VERB
ajst-32481	120	10	interventions	intervention	NOUN
ajst-32481	120	11	.	.	PUNCT
ajst-32481	121	1	however	however	ADV
ajst-32481	121	2	,	,	PUNCT
ajst-32481	121	3	several	several	ADJ
ajst-32481	121	4	key	key	ADJ
ajst-32481	121	5	challenges	challenge	NOUN
ajst-32481	121	6	remain	remain	VERB
ajst-32481	121	7	:	:	PUNCT
ajst-32481	121	8	first	first	ADV
ajst-32481	121	9	,	,	PUNCT
ajst-32481	121	10	most	most	ADJ
ajst-32481	121	11	existing	exist	VERB
ajst-32481	121	12	evidence	evidence	NOUN
ajst-32481	121	13	is	be	AUX
ajst-32481	121	14	correlation	correlation	NOUN
ajst-32481	121	15	-	-	PUNCT
ajst-32481	121	16	based	base	VERB
ajst-32481	121	17	,	,	PUNCT
ajst-32481	121	18	and	and	CCONJ
ajst-32481	121	19	causal	causal	ADJ
ajst-32481	121	20	relationships	relationship	NOUN
ajst-32481	121	21	between	between	ADP
ajst-32481	121	22	gut	gut	NOUN
ajst-32481	121	23	microbiota	microbiota	NOUN
ajst-32481	121	24	and	and	CCONJ
ajst-32481	121	25	ad	ad	NOUN
ajst-32481	121	26	progression	progression	NOUN
ajst-32481	121	27	still	still	ADV
ajst-32481	121	28	require	require	VERB
ajst-32481	121	29	confirmation	confirmation	NOUN
ajst-32481	121	30	through	through	ADP
ajst-32481	121	31	prospective	prospective	ADJ
ajst-32481	121	32	cohort	cohort	NOUN
ajst-32481	121	33	studies	study	NOUN
ajst-32481	121	34	and	and	CCONJ
ajst-32481	121	35	rigorous	rigorous	ADJ
ajst-32481	121	36	animal	animal	NOUN
ajst-32481	121	37	models	model	NOUN
ajst-32481	121	38	.	.	PUNCT
ajst-32481	122	1	second	second	ADJ
ajst-32481	122	2	,	,	PUNCT
ajst-32481	122	3	the	the	DET
ajst-32481	122	4	regulatory	regulatory	ADJ
ajst-32481	122	5	mechanisms	mechanism	NOUN
ajst-32481	122	6	of	of	ADP
ajst-32481	122	7	the	the	DET
ajst-32481	122	8	microbiota	microbiota	NOUN
ajst-32481	122	9	-	-	PUNCT
ajst-32481	122	10	gut	gut	NOUN
ajst-32481	122	11	-	-	PUNCT
ajst-32481	122	12	brain	brain	NOUN
ajst-32481	122	13	axis	axis	NOUN
ajst-32481	122	14	are	be	AUX
ajst-32481	122	15	highly	highly	ADV
ajst-32481	122	16	multidirectional	multidirectional	ADJ
ajst-32481	122	17	and	and	CCONJ
ajst-32481	122	18	dynamic	dynamic	ADJ
ajst-32481	122	19	,	,	PUNCT
ajst-32481	122	20	with	with	ADP
ajst-32481	122	21	microbial	microbial	ADJ
ajst-32481	122	22	metabolites	metabolite	NOUN
ajst-32481	122	23	exerting	exert	VERB
ajst-32481	122	24	pleiotropic	pleiotropic	ADJ
ajst-32481	122	25	effects	effect	NOUN
ajst-32481	122	26	via	via	ADP
ajst-32481	122	27	multiple	multiple	ADJ
ajst-32481	122	28	targets	target	NOUN
ajst-32481	122	29	,	,	PUNCT
ajst-32481	122	30	making	make	VERB
ajst-32481	122	31	mechanistic	mechanistic	ADJ
ajst-32481	122	32	dissection	dissection	NOUN
ajst-32481	122	33	challenging[38	challenging[38	X
ajst-32481	122	34	]	]	X
ajst-32481	122	35	.	.	PUNCT
ajst-32481	123	1	third	third	ADJ
ajst-32481	123	2	,	,	PUNCT
ajst-32481	123	3	gut	gut	ADJ
ajst-32481	123	4	microbiota	microbiota	NOUN
ajst-32481	123	5	abundance	abundance	NOUN
ajst-32481	123	6	displays	display	VERB
ajst-32481	123	7	significant	significant	ADJ
ajst-32481	123	8	inter	inter	ADJ
ajst-32481	123	9	-	-	ADJ
ajst-32481	123	10	individual	individual	ADJ
ajst-32481	123	11	heterogeneity	heterogeneity	NOUN
ajst-32481	123	12	,	,	PUNCT
ajst-32481	123	13	which	which	PRON
ajst-32481	123	14	not	not	PART
ajst-32481	123	15	only	only	ADV
ajst-32481	123	16	affects	affect	VERB
ajst-32481	123	17	comparability	comparability	NOUN
ajst-32481	123	18	across	across	ADP
ajst-32481	123	19	studies	study	NOUN
ajst-32481	123	20	but	but	CCONJ
ajst-32481	123	21	also	also	ADV
ajst-32481	123	22	complicates	complicate	VERB
ajst-32481	123	23	the	the	DET
ajst-32481	123	24	development	development	NOUN
ajst-32481	123	25	of	of	ADP
ajst-32481	123	26	standardized	standardized	ADJ
ajst-32481	123	27	microbial	microbial	ADJ
ajst-32481	123	28	diagnostic	diagnostic	ADJ
ajst-32481	123	29	biomarkers	biomarker	NOUN
ajst-32481	123	30	[	[	X
ajst-32481	123	31	39	39	NUM
ajst-32481	123	32	]	]	PUNCT
ajst-32481	123	33	.	.	PUNCT
ajst-32481	124	1	in	in	ADP
ajst-32481	124	2	terms	term	NOUN
ajst-32481	124	3	of	of	ADP
ajst-32481	124	4	therapeutic	therapeutic	ADJ
ajst-32481	124	5	translation	translation	NOUN
ajst-32481	124	6	,	,	PUNCT
ajst-32481	124	7	although	although	SCONJ
ajst-32481	124	8	microbiota	microbiota	NOUN
ajst-32481	124	9	-	-	PUNCT
ajst-32481	124	10	targeted	target	VERB
ajst-32481	124	11	interventions	intervention	NOUN
ajst-32481	124	12	have	have	AUX
ajst-32481	124	13	shown	show	VERB
ajst-32481	124	14	neuroprotective	neuroprotective	ADJ
ajst-32481	124	15	effects	effect	NOUN
ajst-32481	124	16	in	in	ADP
ajst-32481	124	17	animal	animal	NOUN
ajst-32481	124	18	models	model	NOUN
ajst-32481	124	19	,	,	PUNCT
ajst-32481	124	20	their	their	PRON
ajst-32481	124	21	clinical	clinical	ADJ
ajst-32481	124	22	efficacy	efficacy	NOUN
ajst-32481	124	23	remains	remain	VERB
ajst-32481	124	24	inconsistent	inconsistent	ADJ
ajst-32481	124	25	.	.	PUNCT
ajst-32481	125	1	for	for	ADP
ajst-32481	125	2	example	example	NOUN
ajst-32481	125	3	,	,	PUNCT
ajst-32481	125	4	a	a	DET
ajst-32481	125	5	synbiotic	synbiotic	ADJ
ajst-32481	125	6	formulation	formulation	NOUN
ajst-32481	125	7	of	of	ADP
ajst-32481	125	8	lactobacillus	lactobacillus	NOUN
ajst-32481	125	9	producing	produce	VERB
ajst-32481	125	10	indole-3	indole-3	NOUN
ajst-32481	125	11	-	-	PUNCT
ajst-32481	125	12	lactic	lactic	ADJ
ajst-32481	125	13	acid	acid	NOUN
ajst-32481	125	14	(	(	PUNCT
ajst-32481	125	15	ila	ila	PROPN
ajst-32481	125	16	)	)	PUNCT
ajst-32481	125	17	combined	combine	VERB
ajst-32481	125	18	with	with	ADP
ajst-32481	125	19	inulin	inulin	ADJ
ajst-32481	125	20	improved	improve	VERB
ajst-32481	125	21	cognitive	cognitive	ADJ
ajst-32481	125	22	function	function	NOUN
ajst-32481	125	23	in	in	ADP
ajst-32481	125	24	ad	ad	NOUN
ajst-32481	125	25	mice[40	mice[40	NOUN
ajst-32481	125	26	]	]	PUNCT
ajst-32481	125	27	,	,	PUNCT
ajst-32481	125	28	yet	yet	CCONJ
ajst-32481	125	29	its	its	PRON
ajst-32481	125	30	effectiveness	effectiveness	NOUN
ajst-32481	125	31	in	in	ADP
ajst-32481	125	32	clinical	clinical	ADJ
ajst-32481	125	33	settings	setting	NOUN
ajst-32481	125	34	remains	remain	VERB
ajst-32481	125	35	to	to	PART
ajst-32481	125	36	be	be	AUX
ajst-32481	125	37	validated	validate	VERB
ajst-32481	125	38	,	,	PUNCT
ajst-32481	125	39	highlighting	highlight	VERB
ajst-32481	125	40	the	the	DET
ajst-32481	125	41	need	need	NOUN
ajst-32481	125	42	for	for	ADP
ajst-32481	125	43	more	more	ADV
ajst-32481	125	44	precise	precise	ADJ
ajst-32481	125	45	intervention	intervention	NOUN
ajst-32481	125	46	strategies	strategy	NOUN
ajst-32481	125	47	.	.	PUNCT
ajst-32481	126	1	looking	look	VERB
ajst-32481	126	2	ahead	ahead	ADV
ajst-32481	126	3	,	,	PUNCT
ajst-32481	126	4	research	research	NOUN
ajst-32481	126	5	in	in	ADP
ajst-32481	126	6	this	this	DET
ajst-32481	126	7	field	field	NOUN
ajst-32481	126	8	urgently	urgently	ADV
ajst-32481	126	9	requires	require	VERB
ajst-32481	126	10	a	a	DET
ajst-32481	126	11	multidisciplinary	multidisciplinary	ADJ
ajst-32481	126	12	approach	approach	NOUN
ajst-32481	126	13	.	.	PUNCT
ajst-32481	127	1	integration	integration	NOUN
ajst-32481	127	2	of	of	ADP
ajst-32481	127	3	multi	multi	ADJ
ajst-32481	127	4	-	-	ADJ
ajst-32481	127	5	omics	omics	ADJ
ajst-32481	127	6	technologies	technology	NOUN
ajst-32481	127	7	,	,	PUNCT
ajst-32481	127	8	such	such	ADJ
ajst-32481	127	9	as	as	ADP
ajst-32481	127	10	metagenomics	metagenomic	NOUN
ajst-32481	127	11	and	and	CCONJ
ajst-32481	127	12	metabolomics	metabolomic	NOUN
ajst-32481	127	13	,	,	PUNCT
ajst-32481	127	14	combined	combine	VERB
ajst-32481	127	15	with	with	ADP
ajst-32481	127	16	machine	machine	NOUN
ajst-32481	127	17	learning	learning	NOUN
ajst-32481	127	18	algorithms	algorithm	NOUN
ajst-32481	127	19	,	,	PUNCT
ajst-32481	127	20	holds	hold	VERB
ajst-32481	127	21	promise	promise	NOUN
ajst-32481	127	22	for	for	ADP
ajst-32481	127	23	constructing	construct	VERB
ajst-32481	127	24	more	more	ADV
ajst-32481	127	25	accurate	accurate	ADJ
ajst-32481	127	26	microbiota	microbiota	NOUN
ajst-32481	127	27	-	-	PUNCT
ajst-32481	127	28	ad	ad	NOUN
ajst-32481	127	29	association	association	NOUN
ajst-32481	127	30	models	model	NOUN
ajst-32481	127	31	[	[	X
ajst-32481	127	32	39	39	NUM
ajst-32481	127	33	]	]	PUNCT
ajst-32481	127	34	.	.	PUNCT
ajst-32481	128	1	from	from	ADP
ajst-32481	128	2	a	a	DET
ajst-32481	128	3	translational	translational	ADJ
ajst-32481	128	4	perspective	perspective	NOUN
ajst-32481	128	5	,	,	PUNCT
ajst-32481	128	6	well	well	ADV
ajst-32481	128	7	-	-	PUNCT
ajst-32481	128	8	controlled	control	VERB
ajst-32481	128	9	longitudinal	longitudinal	ADJ
ajst-32481	128	10	intervention	intervention	NOUN
ajst-32481	128	11	studies	study	NOUN
ajst-32481	128	12	are	be	AUX
ajst-32481	128	13	needed	need	VERB
ajst-32481	128	14	,	,	PUNCT
ajst-32481	128	15	with	with	ADP
ajst-32481	128	16	a	a	DET
ajst-32481	128	17	focus	focus	NOUN
ajst-32481	128	18	on	on	ADP
ajst-32481	128	19	specific	specific	ADJ
ajst-32481	128	20	microbial	microbial	ADJ
ajst-32481	128	21	strains	strain	NOUN
ajst-32481	128	22	or	or	CCONJ
ajst-32481	128	23	metabolites	metabolite	NOUN
ajst-32481	128	24	that	that	PRON
ajst-32481	128	25	modulate	modulate	VERB
ajst-32481	128	26	ad	ad	NOUN
ajst-32481	128	27	pathology	pathology	NOUN
ajst-32481	128	28	[	[	X
ajst-32481	128	29	41	41	NUM
ajst-32481	128	30	]	]	PUNCT
ajst-32481	128	31	.	.	PUNCT
ajst-32481	129	1	progress	progress	NOUN
ajst-32481	129	2	in	in	ADP
ajst-32481	129	3	this	this	DET
ajst-32481	129	4	direction	direction	NOUN
ajst-32481	129	5	will	will	AUX
ajst-32481	129	6	not	not	PART
ajst-32481	129	7	only	only	ADV
ajst-32481	129	8	deepen	deepen	VERB
ajst-32481	129	9	the	the	DET
ajst-32481	129	10	understanding	understanding	NOUN
ajst-32481	129	11	of	of	ADP
ajst-32481	129	12	ad	ad	NOUN
ajst-32481	129	13	mechanisms	mechanism	NOUN
ajst-32481	129	14	but	but	CCONJ
ajst-32481	129	15	may	may	AUX
ajst-32481	129	16	also	also	ADV
ajst-32481	129	17	open	open	VERB
ajst-32481	129	18	new	new	ADJ
ajst-32481	129	19	avenues	avenue	NOUN
ajst-32481	129	20	for	for	ADP
ajst-32481	129	21	the	the	DET
ajst-32481	129	22	prevention	prevention	NOUN
ajst-32481	129	23	and	and	CCONJ
ajst-32481	129	24	treatment	treatment	NOUN
ajst-32481	129	25	of	of	ADP
ajst-32481	129	26	neurodegenerative	neurodegenerative	ADJ
ajst-32481	129	27	diseases	disease	NOUN
ajst-32481	129	28	.	.	PUNCT
ajst-32481	130	1	references	reference	NOUN
ajst-32481	130	2	[	[	X
ajst-32481	130	3	1	1	NUM
ajst-32481	130	4	]	]	X
ajst-32481	130	5	adi	adi	PROPN
ajst-32481	130	6	dementia	dementia	PROPN
ajst-32481	130	7	statistics	statistic	NOUN
ajst-32481	130	8	.	.	PUNCT
ajst-32481	131	1	https://www.alzint.org/about/dementia-facts-figures/dementia-statistics/.	https://www.alzint.org/about/dementia-facts-figures/dementia-statistics/.	PROPN
ajst-32481	131	2	[	[	X
ajst-32481	131	3	2	2	NUM
ajst-32481	131	4	]	]	SYM
ajst-32481	131	5	tiwari	tiwari	PROPN
ajst-32481	131	6	,	,	PUNCT
ajst-32481	131	7	s.	s.	PROPN
ajst-32481	131	8	,	,	PUNCT
ajst-32481	131	9	atluri	atluri	PROPN
ajst-32481	131	10	,	,	PUNCT
ajst-32481	131	11	v.	v.	PROPN
ajst-32481	131	12	,	,	PUNCT
ajst-32481	131	13	kaushik	kaushik	PROPN
ajst-32481	131	14	,	,	PUNCT
ajst-32481	131	15	a.	a.	PROPN
ajst-32481	131	16	,	,	PUNCT
ajst-32481	131	17	yndart	yndart	PROPN
ajst-32481	131	18	,	,	PUNCT
ajst-32481	131	19	a.	a.	PROPN
ajst-32481	131	20	&	&	CCONJ
ajst-32481	131	21	nair	nair	PROPN
ajst-32481	131	22	,	,	PUNCT
ajst-32481	131	23	m.	m.	PROPN
ajst-32481	131	24	alzheimer	alzheimer	PROPN
ajst-32481	131	25	’s	’s	PART
ajst-32481	131	26	disease	disease	NOUN
ajst-32481	131	27	:	:	PUNCT
ajst-32481	131	28	pathogenesis	pathogenesis	NOUN
ajst-32481	131	29	,	,	PUNCT
ajst-32481	131	30	diagnostics	diagnostic	NOUN
ajst-32481	131	31	,	,	PUNCT
ajst-32481	131	32	and	and	CCONJ
ajst-32481	131	33	therapeutics	therapeutic	NOUN
ajst-32481	131	34	.	.	PUNCT
ajst-32481	132	1	int	int	NOUN
ajst-32481	132	2	.	.	PUNCT
ajst-32481	133	1	j.	j.	PROPN
ajst-32481	133	2	nanomed	nanome	VERB
ajst-32481	133	3	.	.	PUNCT
ajst-32481	134	1	14	14	NUM
ajst-32481	134	2	,	,	PUNCT
ajst-32481	134	3	5541–5554	5541–5554	NUM
ajst-32481	134	4	(	(	PUNCT
ajst-32481	134	5	2019	2019	NUM
ajst-32481	134	6	)	)	PUNCT
ajst-32481	134	7	.	.	PUNCT
ajst-32481	135	1	[	[	X
ajst-32481	135	2	3	3	X
ajst-32481	135	3	]	]	X
ajst-32481	135	4	potential	potential	ADJ
ajst-32481	135	5	mechanisms	mechanism	NOUN
ajst-32481	135	6	of	of	ADP
ajst-32481	135	7	gut	gut	NOUN
ajst-32481	135	8	microbiota	microbiota	NOUN
ajst-32481	135	9	in	in	ADP
ajst-32481	135	10	amyloid	amyloid	NOUN
ajst-32481	135	11	deposition	deposition	NOUN
ajst-32481	135	12	in	in	ADP
ajst-32481	135	13	cerebral	cerebral	ADJ
ajst-32481	135	14	amyloid	amyloid	NOUN
ajst-32481	135	15	angiopathy	angiopathy	NOUN
ajst-32481	135	16	.	.	PUNCT
ajst-32481	136	1	https://kns.cnki.net/nzkhtml/xmlread/trialread.html?dbcode=cjfd&tablename=cjfdtotal&filen	https://kns.cnki.net/nzkhtml/xmlread/trialread.html?dbcode=cjfd&tablename=cjfdtotal&filen	NUM
ajst-32481	136	2	ame	ame	X
ajst-32481	136	3	=	=	PROPN
ajst-32481	136	4	nxgb202409010&filesourcetype=1&appid	nxgb202409010&filesourcetype=1&appid	ADJ
ajst-32481	136	5	=	=	ADJ
ajst-32481	136	6	kns_basic_psmc&invoice	kns_basic_psmc&invoice	NOUN
ajst-32481	136	7	=	=	NOUN
ajst-32481	136	8	i3fs+ow3pvnl1	i3fs+ow3pvnl1	PROPN
ajst-32481	136	9	t	t	PROPN
ajst-32481	136	10	djafmw5+gjrgg4owo1fo9t+8drmkbh9wb1jyfuku3q8nyc5u+tv33+n5zhmlbykdser1+qp	djafmw5+gjrgg4owo1fo9t+8drmkbh9wb1jyfuku3q8nyc5u+tv33+n5zhmlbykdser1+qp	NOUN
ajst-32481	136	11	mujaptjzf	mujaptjzf	VERB
ajst-32481	136	12	/	/	PUNCT
ajst-32481	136	13	ctqswtq+5h5ztmw9+palk29pkwuurinru3myrloj7ppix5ye6zyl75fu9vg4xnmy	ctqswtq+5h5ztmw9+palk29pkwuurinru3myrloj7ppix5ye6zyl75fu9vg4xnmy	X
ajst-32481	136	14	/emrq4dp9d0o=.	/emrq4dp9d0o=.	PUNCT
ajst-32481	137	1	[	[	X
ajst-32481	137	2	4	4	X
ajst-32481	137	3	]	]	PUNCT
ajst-32481	137	4	exploring	explore	VERB
ajst-32481	137	5	gut	gut	ADJ
ajst-32481	137	6	immune	immune	ADJ
ajst-32481	137	7	mechanisms	mechanism	NOUN
ajst-32481	137	8	with	with	ADP
ajst-32481	137	9	leica	leica	PROPN
ajst-32481	137	10	thunder	thunder	PROPN
ajst-32481	137	11	imaging	imaging	NOUN
ajst-32481	137	12	system	system	NOUN
ajst-32481	137	13	.	.	PUNCT
ajst-32481	138	1	_	_	PRON
ajst-32481	138	2	chemical	chemical	ADJ
ajst-32481	138	3	instrument	instrument	NOUN
ajst-32481	138	4	network	network	PROPN
ajst-32481	138	5	https://www.chem17.com/tech_news/detail/2346919.html	https://www.chem17.com/tech_news/detail/2346919.html	PROPN
ajst-32481	138	6	.	.	PUNCT
ajst-32481	139	1	[	[	X
ajst-32481	139	2	5	5	NUM
ajst-32481	139	3	]	]	PUNCT
ajst-32481	139	4	research	research	NOUN
ajst-32481	139	5	progress	progress	NOUN
ajst-32481	139	6	on	on	ADP
ajst-32481	139	7	the	the	DET
ajst-32481	139	8	correlation	correlation	NOUN
ajst-32481	139	9	between	between	ADP
ajst-32481	139	10	gut	gut	NOUN
ajst-32481	139	11	microbiota	microbiota	NOUN
ajst-32481	139	12	and	and	CCONJ
ajst-32481	139	13	alzheimer	alzheimer	NOUN
ajst-32481	139	14	’s	’s	PART
ajst-32481	139	15	disease	disease	NOUN
ajst-32481	139	16	.	.	PUNCT
ajst-32481	140	1	wanfang	wanfang	PROPN
ajst-32481	140	2	data	data	PROPN
ajst-32481	140	3	(	(	PUNCT
ajst-32481	140	4	2017)._https://d.wanfangdata.com.cn	2017)._https://d.wanfangdata.com.cn	NUM
ajst-32481	140	5	/	/	SYM
ajst-32481	140	6	periodical	periodical	ADJ
ajst-32481	140	7	/	/	SYM
ajst-32481	140	8	zgylxtb201707002	zgylxtb201707002	PROPN
ajst-32481	140	9	(	(	PUNCT
ajst-32481	140	10	2017	2017	NUM
ajst-32481	140	11	)	)	PUNCT
ajst-32481	140	12	.	.	PUNCT
ajst-32481	141	1	[	[	X
ajst-32481	141	2	6	6	NUM
ajst-32481	141	3	]	]	X
ajst-32481	141	4	zhang	zhang	PROPN
ajst-32481	141	5	,	,	PUNCT
ajst-32481	141	6	l.	l.	PROPN
ajst-32481	141	7	,	,	PUNCT
ajst-32481	141	8	liang	liang	PROPN
ajst-32481	141	9	,	,	PUNCT
ajst-32481	141	10	y.	y.	PROPN
ajst-32481	141	11	,	,	PUNCT
ajst-32481	141	12	dou	dou	PROPN
ajst-32481	141	13	,	,	PUNCT
ajst-32481	141	14	r.	r.	PROPN
ajst-32481	141	15	&	&	CCONJ
ajst-32481	141	16	zhang	zhang	PROPN
ajst-32481	141	17	,	,	PUNCT
ajst-32481	141	18	y.	y.	PROPN
ajst-32481	141	19	research	research	NOUN
ajst-32481	141	20	progress	progress	NOUN
ajst-32481	141	21	on	on	ADP
ajst-32481	141	22	the	the	DET
ajst-32481	141	23	correlation	correlation	NOUN
ajst-32481	141	24	between	between	ADP
ajst-32481	141	25	alzheimer	alzheimer	PROPN
ajst-32481	141	26	’s	’s	PART
ajst-32481	141	27	disease	disease	NOUN
ajst-32481	141	28	and	and	CCONJ
ajst-32481	141	29	gut	gut	NOUN
ajst-32481	141	30	microbiota	microbiota	NOUN
ajst-32481	141	31	.	.	PUNCT
ajst-32481	142	1	advances	advance	NOUN
ajst-32481	142	2	in	in	ADP
ajst-32481	142	3	clinical	clinical	ADJ
ajst-32481	142	4	medicine	medicine	NOUN
ajst-32481	142	5	14	14	NUM
ajst-32481	142	6	,	,	PUNCT
ajst-32481	142	7	780	780	NUM
ajst-32481	142	8	(	(	PUNCT
ajst-32481	142	9	2024	2024	NUM
ajst-32481	142	10	)	)	PUNCT
ajst-32481	142	11	.	.	PUNCT
ajst-32481	143	1	104	104	NUM
ajst-32481	144	1	[	[	X
ajst-32481	144	2	7	7	NUM
ajst-32481	144	3	]	]	X
ajst-32481	144	4	zhang	zhang	PROPN
ajst-32481	144	5	,	,	PUNCT
ajst-32481	144	6	t.	t.	PROPN
ajst-32481	144	7	,	,	PUNCT
ajst-32481	144	8	gao	gao	PROPN
ajst-32481	144	9	,	,	PUNCT
ajst-32481	144	10	g.	g.	PROPN
ajst-32481	144	11	,	,	PUNCT
ajst-32481	144	12	kwok	kwok	PROPN
ajst-32481	144	13	,	,	PUNCT
ajst-32481	144	14	l.-y	l.-y	PROPN
ajst-32481	144	15	.	.	PUNCT
ajst-32481	144	16	&	&	CCONJ
ajst-32481	144	17	sun	sun	PROPN
ajst-32481	144	18	,	,	PUNCT
ajst-32481	144	19	z.	z.	PROPN
ajst-32481	144	20	gut	gut	VERB
ajst-32481	144	21	microbiome	microbiome	NOUN
ajst-32481	144	22	-	-	PUNCT
ajst-32481	144	23	targeted	target	VERB
ajst-32481	144	24	therapies	therapy	NOUN
ajst-32481	144	25	for	for	ADP
ajst-32481	144	26	alzheimer	alzheimer	PROPN
ajst-32481	144	27	’s	’s	PART
ajst-32481	144	28	disease	disease	NOUN
ajst-32481	144	29	.	.	PUNCT
ajst-32481	145	1	gut	gut	NOUN
ajst-32481	145	2	microbes	microbe	NOUN
ajst-32481	145	3	15	15	NUM
ajst-32481	145	4	,	,	PUNCT
ajst-32481	145	5	2271613	2271613	NUM
ajst-32481	145	6	.	.	PUNCT
ajst-32481	146	1	[	[	X
ajst-32481	146	2	8	8	NUM
ajst-32481	146	3	]	]	PUNCT
ajst-32481	146	4	the	the	DET
ajst-32481	146	5	human	human	ADJ
ajst-32481	146	6	microbiome	microbiome	PROPN
ajst-32481	146	7	project	project	NOUN
ajst-32481	146	8	consortium	consortium	NOUN
ajst-32481	146	9	.	.	PUNCT
ajst-32481	147	1	structure	structure	NOUN
ajst-32481	147	2	,	,	PUNCT
ajst-32481	147	3	function	function	NOUN
ajst-32481	147	4	and	and	CCONJ
ajst-32481	147	5	diversity	diversity	NOUN
ajst-32481	147	6	of	of	ADP
ajst-32481	147	7	the	the	DET
ajst-32481	147	8	healthy	healthy	ADJ
ajst-32481	147	9	human	human	ADJ
ajst-32481	147	10	microbiome	microbiome	NOUN
ajst-32481	147	11	.	.	PUNCT
ajst-32481	148	1	nature	nature	NOUN
ajst-32481	148	2	486	486	NUM
ajst-32481	148	3	,	,	PUNCT
ajst-32481	148	4	207–214	207–214	NUM
ajst-32481	148	5	(	(	PUNCT
ajst-32481	148	6	2012	2012	NUM
ajst-32481	148	7	)	)	PUNCT
ajst-32481	148	8	.	.	PUNCT
ajst-32481	149	1	[	[	X
ajst-32481	149	2	9	9	NUM
ajst-32481	149	3	]	]	SYM
ajst-32481	149	4	yoo	yoo	PROPN
ajst-32481	149	5	,	,	PUNCT
ajst-32481	149	6	j.	j.	PROPN
ajst-32481	149	7	,	,	PUNCT
ajst-32481	149	8	groer	groer	PROPN
ajst-32481	149	9	,	,	PUNCT
ajst-32481	149	10	m.	m.	NOUN
ajst-32481	149	11	,	,	PUNCT
ajst-32481	149	12	dutra	dutra	PROPN
ajst-32481	149	13	,	,	PUNCT
ajst-32481	149	14	s.	s.	PROPN
ajst-32481	149	15	,	,	PUNCT
ajst-32481	149	16	sarkar	sarkar	PROPN
ajst-32481	149	17	,	,	PUNCT
ajst-32481	149	18	a.	a.	PROPN
ajst-32481	149	19	&	&	CCONJ
ajst-32481	149	20	mcskimming	mcskimming	PROPN
ajst-32481	149	21	,	,	PUNCT
ajst-32481	149	22	d.	d.	PROPN
ajst-32481	149	23	gut	gut	VERB
ajst-32481	149	24	microbiota	microbiota	NOUN
ajst-32481	149	25	and	and	CCONJ
ajst-32481	149	26	immune	immune	ADJ
ajst-32481	149	27	system	system	NOUN
ajst-32481	149	28	interactions	interaction	NOUN
ajst-32481	149	29	.	.	PUNCT
ajst-32481	150	1	microorganisms	microorganism	NOUN
ajst-32481	150	2	8	8	NUM
ajst-32481	150	3	,	,	PUNCT
ajst-32481	150	4	1587	1587	NUM
ajst-32481	150	5	(	(	PUNCT
ajst-32481	150	6	2020	2020	NUM
ajst-32481	150	7	)	)	PUNCT
ajst-32481	150	8	.	.	PUNCT
ajst-32481	151	1	[	[	X
ajst-32481	151	2	10	10	NUM
ajst-32481	151	3	]	]	X
ajst-32481	151	4	wiertsema	wiertsema	ADJ
ajst-32481	151	5	,	,	PUNCT
ajst-32481	151	6	s.	s.	PROPN
ajst-32481	151	7	p.	p.	PROPN
ajst-32481	151	8	,	,	PUNCT
ajst-32481	151	9	van	van	PROPN
ajst-32481	151	10	bergenhenegouwen	bergenhenegouwen	NOUN
ajst-32481	151	11	,	,	PUNCT
ajst-32481	151	12	j.	j.	PROPN
ajst-32481	151	13	,	,	PUNCT
ajst-32481	151	14	garssen	garssen	PROPN
ajst-32481	151	15	,	,	PUNCT
ajst-32481	151	16	j.	j.	PROPN
ajst-32481	151	17	&	&	CCONJ
ajst-32481	151	18	knippels	knippels	PROPN
ajst-32481	151	19	,	,	PUNCT
ajst-32481	151	20	l.	l.	PROPN
ajst-32481	151	21	m.	m.	PROPN
ajst-32481	151	22	j.	j.	PROPN
ajst-32481	152	1	the	the	DET
ajst-32481	152	2	interplay	interplay	NOUN
ajst-32481	152	3	between	between	ADP
ajst-32481	152	4	the	the	DET
ajst-32481	152	5	gut	gut	NOUN
ajst-32481	152	6	microbiome	microbiome	NOUN
ajst-32481	152	7	and	and	CCONJ
ajst-32481	152	8	the	the	DET
ajst-32481	152	9	immune	immune	ADJ
ajst-32481	152	10	system	system	NOUN
ajst-32481	152	11	throughout	throughout	ADP
ajst-32481	152	12	life	life	NOUN
ajst-32481	152	13	and	and	CCONJ
ajst-32481	152	14	the	the	DET
ajst-32481	152	15	role	role	NOUN
ajst-32481	152	16	of	of	ADP
ajst-32481	152	17	nutrition	nutrition	NOUN
ajst-32481	152	18	.	.	PUNCT
ajst-32481	153	1	nutrients	nutrient	NOUN
ajst-32481	153	2	13	13	NUM
ajst-32481	153	3	,	,	PUNCT
ajst-32481	153	4	886	886	NUM
ajst-32481	153	5	(	(	PUNCT
ajst-32481	153	6	2021	2021	NUM
ajst-32481	153	7	)	)	PUNCT
ajst-32481	153	8	.	.	PUNCT
ajst-32481	154	1	[	[	X
ajst-32481	154	2	11	11	NUM
ajst-32481	154	3	]	]	X
ajst-32481	154	4	rowland	rowland	PROPN
ajst-32481	154	5	,	,	PUNCT
ajst-32481	154	6	i.	i.	PROPN
ajst-32481	154	7	et	et	PROPN
ajst-32481	154	8	al	al	PROPN
ajst-32481	154	9	.	.	PROPN
ajst-32481	155	1	gut	gut	VERB
ajst-32481	155	2	microbiota	microbiota	NOUN
ajst-32481	155	3	functions	function	NOUN
ajst-32481	155	4	:	:	PUNCT
ajst-32481	155	5	metabolism	metabolism	NOUN
ajst-32481	155	6	of	of	ADP
ajst-32481	155	7	nutrients	nutrient	NOUN
ajst-32481	155	8	and	and	CCONJ
ajst-32481	155	9	other	other	ADJ
ajst-32481	155	10	food	food	NOUN
ajst-32481	155	11	components	component	NOUN
ajst-32481	155	12	.	.	PUNCT
ajst-32481	156	1	eur	eur	PROPN
ajst-32481	156	2	.	.	PUNCT
ajst-32481	157	1	j.	j.	PROPN
ajst-32481	157	2	nutr	nutr	PROPN
ajst-32481	157	3	.	.	PROPN
ajst-32481	157	4	57	57	NUM
ajst-32481	157	5	,	,	PUNCT
ajst-32481	157	6	1–24	1–24	PROPN
ajst-32481	157	7	(	(	PUNCT
ajst-32481	157	8	2018	2018	NUM
ajst-32481	157	9	)	)	PUNCT
ajst-32481	157	10	.	.	PUNCT
ajst-32481	158	1	[	[	X
ajst-32481	158	2	12	12	NUM
ajst-32481	158	3	]	]	PUNCT
ajst-32481	158	4	mitrea	mitrea	PROPN
ajst-32481	158	5	,	,	PUNCT
ajst-32481	158	6	l.	l.	PROPN
ajst-32481	158	7	,	,	PUNCT
ajst-32481	158	8	nemeş	nemeş	NOUN
ajst-32481	158	9	,	,	PUNCT
ajst-32481	158	10	s.-a	s.-a	NOUN
ajst-32481	158	11	.	.	PROPN
ajst-32481	158	12	,	,	PUNCT
ajst-32481	158	13	szabo	szabo	PROPN
ajst-32481	158	14	,	,	PUNCT
ajst-32481	158	15	k.	k.	PROPN
ajst-32481	158	16	,	,	PUNCT
ajst-32481	158	17	teleky	teleky	NOUN
ajst-32481	158	18	,	,	PUNCT
ajst-32481	158	19	b.-e	b.-e	PROPN
ajst-32481	158	20	.	.	PUNCT
ajst-32481	158	21	&	&	CCONJ
ajst-32481	158	22	vodnar	vodnar	PROPN
ajst-32481	158	23	,	,	PUNCT
ajst-32481	158	24	d.-c	d.-c	PROPN
ajst-32481	158	25	.	.	PUNCT
ajst-32481	159	1	guts	gut	VERB
ajst-32481	159	2	imbalance	imbalance	NOUN
ajst-32481	159	3	imbalances	imbalance	NOUN
ajst-32481	159	4	the	the	DET
ajst-32481	159	5	brain	brain	NOUN
ajst-32481	159	6	:	:	PUNCT
ajst-32481	159	7	a	a	DET
ajst-32481	159	8	review	review	NOUN
ajst-32481	159	9	of	of	ADP
ajst-32481	159	10	gut	gut	NOUN
ajst-32481	159	11	microbiota	microbiota	NOUN
ajst-32481	159	12	association	association	NOUN
ajst-32481	159	13	with	with	ADP
ajst-32481	159	14	neurological	neurological	ADJ
ajst-32481	159	15	and	and	CCONJ
ajst-32481	159	16	psychiatric	psychiatric	ADJ
ajst-32481	159	17	disorders	disorder	NOUN
ajst-32481	159	18	.	.	PUNCT
ajst-32481	160	1	front	front	ADJ
ajst-32481	160	2	.	.	PUNCT
ajst-32481	161	1	med	med	PROPN
ajst-32481	161	2	.	.	PROPN
ajst-32481	161	3	9	9	NUM
ajst-32481	161	4	,	,	PUNCT
ajst-32481	161	5	813204	813204	NUM
ajst-32481	161	6	(	(	PUNCT
ajst-32481	161	7	2022	2022	NUM
ajst-32481	161	8	)	)	PUNCT
ajst-32481	161	9	.	.	PUNCT
ajst-32481	162	1	[	[	X
ajst-32481	162	2	13	13	NUM
ajst-32481	162	3	]	]	X
ajst-32481	162	4	liu	liu	PROPN
ajst-32481	162	5	,	,	PUNCT
ajst-32481	162	6	b.-n	b.-n	PROPN
ajst-32481	162	7	.	.	PROPN
ajst-32481	162	8	,	,	PUNCT
ajst-32481	162	9	liu	liu	PROPN
ajst-32481	162	10	,	,	PUNCT
ajst-32481	162	11	x.-t	x.-t	PROPN
ajst-32481	162	12	.	.	PROPN
ajst-32481	162	13	,	,	PUNCT
ajst-32481	162	14	liang	liang	PROPN
ajst-32481	162	15	,	,	PUNCT
ajst-32481	162	16	z.-h	z.-h	PROPN
ajst-32481	162	17	.	.	PUNCT
ajst-32481	162	18	&	&	CCONJ
ajst-32481	162	19	wang	wang	PROPN
ajst-32481	162	20	,	,	PUNCT
ajst-32481	162	21	j.-h	j.-h	PROPN
ajst-32481	162	22	.	.	PUNCT
ajst-32481	163	1	gut	gut	VERB
ajst-32481	163	2	microbiota	microbiota	NOUN
ajst-32481	163	3	in	in	ADP
ajst-32481	163	4	obesity	obesity	NOUN
ajst-32481	163	5	.	.	PUNCT
ajst-32481	164	1	world	world	PROPN
ajst-32481	164	2	j.	j.	PROPN
ajst-32481	164	3	gastroenterol	gastroenterol	PROPN
ajst-32481	164	4	.	.	PUNCT
ajst-32481	165	1	27	27	NUM
ajst-32481	165	2	,	,	PUNCT
ajst-32481	165	3	3837–3850	3837–3850	NUM
ajst-32481	165	4	(	(	PUNCT
ajst-32481	165	5	2021	2021	NUM
ajst-32481	165	6	)	)	PUNCT
ajst-32481	165	7	.	.	PUNCT
ajst-32481	166	1	[	[	X
ajst-32481	166	2	14	14	NUM
ajst-32481	166	3	]	]	SYM
ajst-32481	166	4	tiwari	tiwari	PROPN
ajst-32481	166	5	,	,	PUNCT
ajst-32481	166	6	s.	s.	PROPN
ajst-32481	166	7	,	,	PUNCT
ajst-32481	166	8	atluri	atluri	PROPN
ajst-32481	166	9	,	,	PUNCT
ajst-32481	166	10	v.	v.	PROPN
ajst-32481	166	11	,	,	PUNCT
ajst-32481	166	12	kaushik	kaushik	PROPN
ajst-32481	166	13	,	,	PUNCT
ajst-32481	166	14	a.	a.	PROPN
ajst-32481	166	15	,	,	PUNCT
ajst-32481	166	16	yndart	yndart	PROPN
ajst-32481	166	17	,	,	PUNCT
ajst-32481	166	18	a.	a.	PROPN
ajst-32481	166	19	&	&	CCONJ
ajst-32481	166	20	nair	nair	PROPN
ajst-32481	166	21	,	,	PUNCT
ajst-32481	166	22	m.	m.	PROPN
ajst-32481	166	23	alzheimer	alzheimer	PROPN
ajst-32481	166	24	’s	’s	PART
ajst-32481	166	25	disease	disease	NOUN
ajst-32481	166	26	:	:	PUNCT
ajst-32481	166	27	pathogenesis	pathogenesis	NOUN
ajst-32481	166	28	,	,	PUNCT
ajst-32481	166	29	diagnostics	diagnostic	NOUN
ajst-32481	166	30	,	,	PUNCT
ajst-32481	166	31	and	and	CCONJ
ajst-32481	166	32	therapeutics	therapeutic	NOUN
ajst-32481	166	33	.	.	PUNCT
ajst-32481	167	1	int	int	NOUN
ajst-32481	167	2	.	.	PUNCT
ajst-32481	168	1	j.	j.	PROPN
ajst-32481	168	2	nanomed	nanome	VERB
ajst-32481	168	3	.	.	PUNCT
ajst-32481	169	1	14	14	NUM
ajst-32481	169	2	,	,	PUNCT
ajst-32481	169	3	5541–5554	5541–5554	NUM
ajst-32481	169	4	(	(	PUNCT
ajst-32481	169	5	2019	2019	NUM
ajst-32481	169	6	)	)	PUNCT
ajst-32481	169	7	.	.	PUNCT
ajst-32481	170	1	[	[	X
ajst-32481	170	2	15	15	NUM
ajst-32481	170	3	]	]	X
ajst-32481	170	4	long	long	ADV
ajst-32481	170	5	,	,	PUNCT
ajst-32481	170	6	j.	j.	PROPN
ajst-32481	170	7	m.	m.	PROPN
ajst-32481	170	8	&	&	CCONJ
ajst-32481	170	9	holtzman	holtzman	PROPN
ajst-32481	170	10	,	,	PUNCT
ajst-32481	170	11	d.	d.	PROPN
ajst-32481	170	12	m.	m.	PROPN
ajst-32481	170	13	alzheimer	alzheimer	PROPN
ajst-32481	170	14	disease	disease	PROPN
ajst-32481	170	15	:	:	PUNCT
ajst-32481	170	16	an	an	DET
ajst-32481	170	17	update	update	NOUN
ajst-32481	170	18	on	on	ADP
ajst-32481	170	19	pathobiology	pathobiology	NOUN
ajst-32481	170	20	and	and	CCONJ
ajst-32481	170	21	treatment	treatment	NOUN
ajst-32481	170	22	strategies	strategy	NOUN
ajst-32481	170	23	.	.	PUNCT
ajst-32481	171	1	cell	cell	NOUN
ajst-32481	171	2	179	179	NUM
ajst-32481	171	3	,	,	PUNCT
ajst-32481	171	4	312–339	312–339	NUM
ajst-32481	171	5	(	(	PUNCT
ajst-32481	171	6	2019	2019	NUM
ajst-32481	171	7	)	)	PUNCT
ajst-32481	171	8	.	.	PUNCT
ajst-32481	172	1	[	[	X
ajst-32481	172	2	16	16	NUM
ajst-32481	172	3	]	]	X
ajst-32481	172	4	islam	islam	PROPN
ajst-32481	172	5	,	,	PUNCT
ajst-32481	172	6	t.	t.	PROPN
ajst-32481	172	7	et	et	PROPN
ajst-32481	172	8	al	al	PROPN
ajst-32481	172	9	.	.	PROPN
ajst-32481	172	10	phospho	phospho	PROPN
ajst-32481	172	11	-	-	PUNCT
ajst-32481	172	12	tau	tau	PROPN
ajst-32481	172	13	serine-262	serine-262	NOUN
ajst-32481	172	14	and	and	CCONJ
ajst-32481	172	15	serine-356	serine-356	NOUN
ajst-32481	172	16	as	as	ADP
ajst-32481	172	17	biomarkers	biomarker	NOUN
ajst-32481	172	18	of	of	ADP
ajst-32481	172	19	pre	pre	ADJ
ajst-32481	172	20	-	-	ADJ
ajst-32481	172	21	tangle	tangle	ADJ
ajst-32481	172	22	soluble	soluble	ADJ
ajst-32481	172	23	tau	tau	PROPN
ajst-32481	172	24	assemblies	assembly	NOUN
ajst-32481	172	25	in	in	ADP
ajst-32481	172	26	alzheimer	alzheimer	PROPN
ajst-32481	172	27	’s	’s	PART
ajst-32481	172	28	disease	disease	NOUN
ajst-32481	172	29	.	.	PUNCT
ajst-32481	173	1	nat	nat	PROPN
ajst-32481	173	2	.	.	PUNCT
ajst-32481	174	1	med	med	PROPN
ajst-32481	174	2	.	.	PROPN
ajst-32481	175	1	31	31	NUM
ajst-32481	175	2	,	,	PUNCT
ajst-32481	175	3	574–588	574–588	NUM
ajst-32481	175	4	(	(	PUNCT
ajst-32481	175	5	2025	2025	NUM
ajst-32481	175	6	)	)	PUNCT
ajst-32481	175	7	.	.	PUNCT
ajst-32481	176	1	[	[	X
ajst-32481	176	2	17	17	NUM
ajst-32481	176	3	]	]	X
ajst-32481	176	4	abubakar	abubakar	PROPN
ajst-32481	176	5	,	,	PUNCT
ajst-32481	176	6	m.	m.	PROPN
ajst-32481	176	7	b.	b.	PROPN
ajst-32481	176	8	et	et	PROPN
ajst-32481	176	9	al	al	PROPN
ajst-32481	176	10	.	.	PROPN
ajst-32481	176	11	alzheimer	alzheimer	PROPN
ajst-32481	176	12	’s	’s	PART
ajst-32481	176	13	disease	disease	NOUN
ajst-32481	176	14	:	:	PUNCT
ajst-32481	176	15	an	an	DET
ajst-32481	176	16	update	update	NOUN
ajst-32481	176	17	and	and	CCONJ
ajst-32481	176	18	insights	insight	NOUN
ajst-32481	176	19	into	into	ADP
ajst-32481	176	20	pathophysiology	pathophysiology	NOUN
ajst-32481	176	21	.	.	PUNCT
ajst-32481	177	1	front	front	ADJ
ajst-32481	177	2	.	.	PUNCT
ajst-32481	178	1	aging	age	VERB
ajst-32481	178	2	neurosci	neurosci	NOUN
ajst-32481	178	3	.	.	PUNCT
ajst-32481	179	1	14	14	NUM
ajst-32481	179	2	,	,	PUNCT
ajst-32481	179	3	742408	742408	NUM
ajst-32481	179	4	(	(	PUNCT
ajst-32481	179	5	2022	2022	NUM
ajst-32481	179	6	)	)	PUNCT
ajst-32481	179	7	.	.	PUNCT
ajst-32481	180	1	[	[	X
ajst-32481	180	2	18	18	NUM
ajst-32481	180	3	]	]	PUNCT
ajst-32481	180	4	hensley	hensley	NOUN
ajst-32481	180	5	,	,	PUNCT
ajst-32481	180	6	k.	k.	PROPN
ajst-32481	180	7	neuroinflammation	neuroinflammation	PROPN
ajst-32481	180	8	in	in	ADP
ajst-32481	180	9	alzheimer	alzheimer	PROPN
ajst-32481	180	10	’s	’s	PART
ajst-32481	180	11	disease	disease	NOUN
ajst-32481	180	12	:	:	PUNCT
ajst-32481	180	13	mechanisms	mechanism	NOUN
ajst-32481	180	14	,	,	PUNCT
ajst-32481	180	15	pathologic	pathologic	ADJ
ajst-32481	180	16	consequences	consequence	NOUN
ajst-32481	180	17	,	,	PUNCT
ajst-32481	180	18	and	and	CCONJ
ajst-32481	180	19	potential	potential	ADJ
ajst-32481	180	20	for	for	ADP
ajst-32481	180	21	therapeutic	therapeutic	ADJ
ajst-32481	180	22	manipulation	manipulation	NOUN
ajst-32481	180	23	.	.	PUNCT
ajst-32481	181	1	j.	j.	PROPN
ajst-32481	181	2	alzheimers	alzheimers	PROPN
ajst-32481	181	3	dis	dis	PROPN
ajst-32481	181	4	.	.	PROPN
ajst-32481	182	1	21	21	NUM
ajst-32481	182	2	,	,	PUNCT
ajst-32481	182	3	1–14	1–14	PROPN
ajst-32481	182	4	(	(	PUNCT
ajst-32481	182	5	2010	2010	NUM
ajst-32481	182	6	)	)	PUNCT
ajst-32481	182	7	.	.	PUNCT
ajst-32481	183	1	[	[	X
ajst-32481	183	2	19	19	NUM
ajst-32481	183	3	]	]	SYM
ajst-32481	183	4	jäkel	jäkel	PROPN
ajst-32481	183	5	,	,	PUNCT
ajst-32481	183	6	s.	s.	PROPN
ajst-32481	183	7	&	&	CCONJ
ajst-32481	183	8	dimou	dimou	PROPN
ajst-32481	183	9	,	,	PUNCT
ajst-32481	183	10	l.	l.	PROPN
ajst-32481	183	11	glial	glial	ADJ
ajst-32481	183	12	cells	cell	NOUN
ajst-32481	183	13	and	and	CCONJ
ajst-32481	183	14	their	their	PRON
ajst-32481	183	15	function	function	NOUN
ajst-32481	183	16	in	in	ADP
ajst-32481	183	17	the	the	DET
ajst-32481	183	18	adult	adult	NOUN
ajst-32481	183	19	brain	brain	NOUN
ajst-32481	183	20	:	:	PUNCT
ajst-32481	183	21	a	a	DET
ajst-32481	183	22	historical	historical	ADJ
ajst-32481	183	23	perspective	perspective	NOUN
ajst-32481	183	24	.	.	PUNCT
ajst-32481	184	1	front	front	ADJ
ajst-32481	184	2	.	.	PUNCT
ajst-32481	185	1	cell	cell	NOUN
ajst-32481	185	2	.	.	PUNCT
ajst-32481	186	1	neurosci	neurosci	PROPN
ajst-32481	186	2	.	.	PUNCT
ajst-32481	187	1	11	11	NUM
ajst-32481	187	2	,	,	PUNCT
ajst-32481	187	3	24	24	NUM
ajst-32481	187	4	(	(	PUNCT
ajst-32481	187	5	2017	2017	NUM
ajst-32481	187	6	)	)	PUNCT
ajst-32481	187	7	.	.	PUNCT
ajst-32481	188	1	[	[	X
ajst-32481	188	2	20	20	NUM
ajst-32481	188	3	]	]	X
ajst-32481	188	4	microglia	microglia	ADJ
ajst-32481	188	5	drive	drive	NOUN
ajst-32481	188	6	amyloid	amyloid	NOUN
ajst-32481	188	7	-	-	PUNCT
ajst-32481	188	8	β	β	NOUN
ajst-32481	188	9	clearance	clearance	NOUN
ajst-32481	188	10	in	in	ADP
ajst-32481	188	11	immunized	immunize	VERB
ajst-32481	188	12	patients	patient	NOUN
ajst-32481	188	13	with	with	ADP
ajst-32481	188	14	alzheimer	alzheimer	PROPN
ajst-32481	188	15	’s	’s	PART
ajst-32481	188	16	disease	disease	NOUN
ajst-32481	188	17	.	.	PUNCT
ajst-32481	189	1	nat	nat	PROPN
ajst-32481	189	2	.	.	PUNCT
ajst-32481	189	3	med	med	PROPN
ajst-32481	189	4	.	.	PUNCT
ajst-32481	190	1	(	(	PUNCT
ajst-32481	190	2	2025	2025	NUM
ajst-32481	190	3	)	)	PUNCT
ajst-32481	190	4	.	.	PUNCT
ajst-32481	191	1	[	[	X
ajst-32481	191	2	21	21	NUM
ajst-32481	191	3	]	]	X
ajst-32481	191	4	liu	liu	PROPN
ajst-32481	191	5	,	,	PUNCT
ajst-32481	191	6	j.	j.	PROPN
ajst-32481	191	7	et	et	PROPN
ajst-32481	191	8	al	al	PROPN
ajst-32481	191	9	.	.	PROPN
ajst-32481	191	10	microglial	microglial	PROPN
ajst-32481	191	11	tmem119	tmem119	PRON
ajst-32481	191	12	binds	bind	VERB
ajst-32481	191	13	to	to	PART
ajst-32481	191	14	amyloid	amyloid	NOUN
ajst-32481	191	15	-	-	PUNCT
ajst-32481	191	16	β	β	NOUN
ajst-32481	191	17	to	to	PART
ajst-32481	191	18	promote	promote	VERB
ajst-32481	191	19	its	its	PRON
ajst-32481	191	20	clearance	clearance	NOUN
ajst-32481	191	21	in	in	ADP
ajst-32481	191	22	an	an	DET
ajst-32481	191	23	aβ	aβ	NOUN
ajst-32481	191	24	-	-	PUNCT
ajst-32481	191	25	depositing	deposit	VERB
ajst-32481	191	26	mouse	mouse	NOUN
ajst-32481	191	27	model	model	NOUN
ajst-32481	191	28	of	of	ADP
ajst-32481	191	29	alzheimer	alzheimer	PROPN
ajst-32481	191	30	’s	’s	PART
ajst-32481	191	31	disease	disease	NOUN
ajst-32481	191	32	.	.	PUNCT
ajst-32481	192	1	immunity	immunity	NOUN
ajst-32481	192	2	(	(	PUNCT
ajst-32481	192	3	2025	2025	NUM
ajst-32481	192	4	)	)	PUNCT
ajst-32481	192	5	.	.	PUNCT
ajst-32481	193	1	[	[	X
ajst-32481	193	2	22	22	NUM
ajst-32481	193	3	]	]	X
ajst-32481	193	4	uddin	uddin	PROPN
ajst-32481	193	5	,	,	PUNCT
ajst-32481	193	6	m.	m.	NOUN
ajst-32481	193	7	s.	s.	PROPN
ajst-32481	193	8	et	et	PROPN
ajst-32481	193	9	al	al	PROPN
ajst-32481	193	10	.	.	PUNCT
ajst-32481	194	1	neuroinflammatory	neuroinflammatory	NOUN
ajst-32481	194	2	signaling	signal	VERB
ajst-32481	194	3	in	in	ADP
ajst-32481	194	4	the	the	DET
ajst-32481	194	5	pathogenesis	pathogenesis	NOUN
ajst-32481	194	6	of	of	ADP
ajst-32481	194	7	alzheimer	alzheimer	PROPN
ajst-32481	194	8	’s	’s	PART
ajst-32481	194	9	disease	disease	NOUN
ajst-32481	194	10	.	.	PUNCT
ajst-32481	195	1	curr	curr	PROPN
ajst-32481	195	2	.	.	PUNCT
ajst-32481	196	1	neuropharmacol	neuropharmacol	PROPN
ajst-32481	196	2	.	.	PUNCT
ajst-32481	197	1	20	20	NUM
ajst-32481	197	2	,	,	PUNCT
ajst-32481	197	3	126–146	126–146	NUM
ajst-32481	197	4	(	(	PUNCT
ajst-32481	197	5	2022	2022	NUM
ajst-32481	197	6	)	)	PUNCT
ajst-32481	197	7	.	.	PUNCT
ajst-32481	198	1	[	[	X
ajst-32481	198	2	23	23	NUM
ajst-32481	198	3	]	]	X
ajst-32481	198	4	kowalski	kowalski	PROPN
ajst-32481	198	5	,	,	PUNCT
ajst-32481	198	6	k.	k.	PROPN
ajst-32481	198	7	&	&	CCONJ
ajst-32481	198	8	mulak	mulak	PROPN
ajst-32481	198	9	,	,	PUNCT
ajst-32481	198	10	a.	a.	NOUN
ajst-32481	198	11	brain	brain	NOUN
ajst-32481	198	12	–	–	PUNCT
ajst-32481	198	13	gut	gut	ADJ
ajst-32481	198	14	–	–	PUNCT
ajst-32481	198	15	microbiota	microbiota	NOUN
ajst-32481	198	16	axis	axis	NOUN
ajst-32481	198	17	in	in	ADP
ajst-32481	198	18	alzheimer	alzheimer	PROPN
ajst-32481	198	19	’s	’s	PART
ajst-32481	198	20	disease	disease	NOUN
ajst-32481	198	21	.	.	PUNCT
ajst-32481	199	1	j.	j.	PROPN
ajst-32481	199	2	neurogastroenterol	neurogastroenterol	PROPN
ajst-32481	199	3	.	.	PUNCT
ajst-32481	200	1	motil	motil	PROPN
ajst-32481	200	2	.	.	PROPN
ajst-32481	201	1	25	25	NUM
ajst-32481	201	2	,	,	PUNCT
ajst-32481	201	3	48–60	48–60	NUM
ajst-32481	201	4	(	(	PUNCT
ajst-32481	201	5	2019	2019	NUM
ajst-32481	201	6	)	)	PUNCT
ajst-32481	201	7	.	.	PUNCT
ajst-32481	202	1	[	[	X
ajst-32481	202	2	24	24	NUM
ajst-32481	202	3	]	]	SYM
ajst-32481	202	4	varesi	varesi	NOUN
ajst-32481	202	5	,	,	PUNCT
ajst-32481	202	6	a.	a.	PROPN
ajst-32481	202	7	et	et	PROPN
ajst-32481	202	8	al	al	PROPN
ajst-32481	202	9	.	.	PUNCT
ajst-32481	203	1	the	the	DET
ajst-32481	203	2	potential	potential	ADJ
ajst-32481	203	3	role	role	NOUN
ajst-32481	203	4	of	of	ADP
ajst-32481	203	5	gut	gut	NOUN
ajst-32481	203	6	microbiota	microbiota	NOUN
ajst-32481	203	7	in	in	ADP
ajst-32481	203	8	alzheimer	alzheimer	PROPN
ajst-32481	203	9	’s	’s	PART
ajst-32481	203	10	disease	disease	NOUN
ajst-32481	203	11	:	:	PUNCT
ajst-32481	203	12	from	from	ADP
ajst-32481	203	13	diagnosis	diagnosis	NOUN
ajst-32481	203	14	to	to	ADP
ajst-32481	203	15	treatment	treatment	NOUN
ajst-32481	203	16	.	.	PUNCT
ajst-32481	204	1	nutrients	nutrient	NOUN
ajst-32481	204	2	14	14	NUM
ajst-32481	204	3	,	,	PUNCT
ajst-32481	204	4	668	668	NUM
ajst-32481	204	5	(	(	PUNCT
ajst-32481	204	6	2022	2022	NUM
ajst-32481	204	7	)	)	PUNCT
ajst-32481	204	8	.	.	PUNCT
ajst-32481	205	1	[	[	X
ajst-32481	205	2	25	25	NUM
ajst-32481	205	3	]	]	PUNCT
ajst-32481	205	4	williams	williams	PROPN
ajst-32481	205	5	,	,	PUNCT
ajst-32481	205	6	z.	z.	PROPN
ajst-32481	205	7	a.	a.	PROPN
ajst-32481	205	8	p.	p.	PROPN
ajst-32481	205	9	et	et	PROPN
ajst-32481	206	1	al	al	PROPN
ajst-32481	206	2	.	.	PROPN
ajst-32481	207	1	do	do	AUX
ajst-32481	207	2	microbes	microbe	NOUN
ajst-32481	207	3	play	play	VERB
ajst-32481	207	4	a	a	DET
ajst-32481	207	5	role	role	NOUN
ajst-32481	207	6	in	in	ADP
ajst-32481	207	7	alzheimer	alzheimer	PROPN
ajst-32481	207	8	’s	’s	PART
ajst-32481	207	9	disease	disease	NOUN
ajst-32481	207	10	?	?	PUNCT
ajst-32481	208	1	microb	microb	PROPN
ajst-32481	208	2	.	.	PUNCT
ajst-32481	209	1	biotechnol	biotechnol	PROPN
ajst-32481	209	2	.	.	PUNCT
ajst-32481	210	1	17	17	NUM
ajst-32481	210	2	,	,	PUNCT
ajst-32481	210	3	e14462	e14462	NOUN
ajst-32481	210	4	(	(	PUNCT
ajst-32481	210	5	2024	2024	NUM
ajst-32481	210	6	)	)	PUNCT
ajst-32481	210	7	.	.	PUNCT
ajst-32481	211	1	[	[	X
ajst-32481	211	2	26	26	NUM
ajst-32481	211	3	]	]	PUNCT
ajst-32481	211	4	sudo	sudo	NOUN
ajst-32481	211	5	,	,	PUNCT
ajst-32481	211	6	n.	n.	PROPN
ajst-32481	211	7	et	et	PROPN
ajst-32481	211	8	al	al	PROPN
ajst-32481	211	9	.	.	PROPN
ajst-32481	211	10	postnatal	postnatal	ADJ
ajst-32481	211	11	microbial	microbial	ADJ
ajst-32481	211	12	colonization	colonization	NOUN
ajst-32481	211	13	programs	program	NOUN
ajst-32481	211	14	the	the	DET
ajst-32481	211	15	hypothalamic	hypothalamic	ADJ
ajst-32481	211	16	-	-	PUNCT
ajst-32481	211	17	pituitary	pituitary	ADJ
ajst-32481	211	18	-	-	PUNCT
ajst-32481	211	19	adrenal	adrenal	ADJ
ajst-32481	211	20	system	system	NOUN
ajst-32481	211	21	for	for	ADP
ajst-32481	211	22	stress	stress	ADJ
ajst-32481	211	23	response	response	NOUN
ajst-32481	211	24	in	in	ADP
ajst-32481	211	25	mice	mouse	NOUN
ajst-32481	211	26	.	.	PUNCT
ajst-32481	212	1	j.	j.	PROPN
ajst-32481	212	2	physiol	physiol	PROPN
ajst-32481	212	3	.	.	PUNCT
ajst-32481	213	1	558	558	NUM
ajst-32481	213	2	,	,	PUNCT
ajst-32481	213	3	263–275	263–275	NUM
ajst-32481	213	4	(	(	PUNCT
ajst-32481	213	5	2004	2004	NUM
ajst-32481	213	6	)	)	PUNCT
ajst-32481	213	7	.	.	PUNCT
ajst-32481	214	1	[	[	X
ajst-32481	214	2	27	27	NUM
ajst-32481	214	3	]	]	X
ajst-32481	214	4	advances	advance	NOUN
ajst-32481	214	5	in	in	ADP
ajst-32481	214	6	gut	gut	NOUN
ajst-32481	214	7	–	–	PUNCT
ajst-32481	214	8	microbiota	microbiota	NOUN
ajst-32481	214	9	–	–	PUNCT
ajst-32481	214	10	brain	brain	NOUN
ajst-32481	214	11	axis	axis	NOUN
ajst-32481	214	12	research	research	NOUN
ajst-32481	214	13	and	and	CCONJ
ajst-32481	214	14	neurological	neurological	ADJ
ajst-32481	214	15	disorders	disorder	NOUN
ajst-32481	214	16	.	.	PUNCT
ajst-32481	215	1	cnki	cnki	PROPN
ajst-32481	215	2	.	.	PUNCT
ajst-32481	216	1	https://	https://	PROPN
ajst-32481	216	2	kns	kns	PROPN
ajst-32481	216	3	.	.	PUNCT
ajst-32481	217	1	cnki.net/kcms2/article/abstract?v=fr434wv7ssyax9vav4yuqpfjrmfab3l503rl-xnldowpwzlsjqgkzzbkfhpribi4fj8jqhzqix3eeki8kuygdomzvkudehhav4dqrxpij96b1vq-7kmyf	cnki.net/kcms2/article/abstract?v=fr434wv7ssyax9vav4yuqpfjrmfab3l503rl-xnldowpwzlsjqgkzzbkfhpribi4fj8jqhzqix3eeki8kuygdomzvkudehhav4dqrxpij96b1vq-7kmyf	PROPN
ajst-32481	217	2	pkpchu7	pkpchu7	VERB
ajst-32481	217	3	ah	ah	INTJ
ajst-32481	217	4	vhdz	vhdz	NOUN
ajst-32481	217	5	-	-	PUNCT
ajst-32481	217	6	aamrdb5cqvblsvxlv1xq8z95m57ownzvug2qycimuqx73chvpg	aamrdb5cqvblsvxlv1xq8z95m57ownzvug2qycimuqx73chvpg	NOUN
ajst-32481	217	7	=	=	PUNCT
ajst-32481	218	1	=	=	NOUN
ajst-32481	218	2	&	&	CCONJ
ajst-32481	218	3	uniplatform	uniplatform	PROPN
ajst-32481	218	4	=	=	PROPN
ajst-32481	218	5	nzkpt&language	nzkpt&language	PROPN
ajst-32481	218	6	=	=	SYM
ajst-32481	218	7	chs	chs	X
ajst-32481	218	8	.	.	PUNCT
ajst-32481	219	1	[	[	X
ajst-32481	219	2	28	28	NUM
ajst-32481	219	3	]	]	X
ajst-32481	219	4	reigstad	reigstad	PROPN
ajst-32481	219	5	,	,	PUNCT
ajst-32481	220	1	c.	c.	PROPN
ajst-32481	220	2	s.	s.	PROPN
ajst-32481	220	3	et	et	PROPN
ajst-32481	220	4	al	al	PROPN
ajst-32481	220	5	.	.	PUNCT
ajst-32481	221	1	gut	gut	NOUN
ajst-32481	221	2	microbes	microbe	NOUN
ajst-32481	221	3	promote	promote	VERB
ajst-32481	221	4	colonic	colonic	NOUN
ajst-32481	221	5	serotonin	serotonin	NOUN
ajst-32481	221	6	production	production	NOUN
ajst-32481	221	7	through	through	ADP
ajst-32481	221	8	scfas	scfas	NOUN
ajst-32481	221	9	acting	act	VERB
ajst-32481	221	10	on	on	ADP
ajst-32481	221	11	enterochromaffin	enterochromaffin	NOUN
ajst-32481	221	12	cells	cell	NOUN
ajst-32481	221	13	.	.	PUNCT
ajst-32481	222	1	faseb	faseb	PROPN
ajst-32481	222	2	j.	j.	PROPN
ajst-32481	222	3	29	29	NUM
ajst-32481	222	4	,	,	PUNCT
ajst-32481	222	5	1395–1403	1395–1403	PRON
ajst-32481	222	6	(	(	PUNCT
ajst-32481	222	7	2015	2015	NUM
ajst-32481	222	8	)	)	PUNCT
ajst-32481	222	9	.	.	PUNCT
ajst-32481	223	1	[	[	X
ajst-32481	223	2	29	29	NUM
ajst-32481	223	3	]	]	X
ajst-32481	223	4	bravo	bravo	PROPN
ajst-32481	223	5	,	,	PUNCT
ajst-32481	223	6	j.	j.	PROPN
ajst-32481	223	7	a.	a.	PROPN
ajst-32481	223	8	et	et	PROPN
ajst-32481	223	9	al	al	PROPN
ajst-32481	223	10	.	.	PUNCT
ajst-32481	223	11	ingestion	ingestion	NOUN
ajst-32481	223	12	of	of	ADP
ajst-32481	223	13	lactobacillus	lactobacillus	NOUN
ajst-32481	223	14	regulates	regulate	VERB
ajst-32481	223	15	emotional	emotional	ADJ
ajst-32481	223	16	behavior	behavior	NOUN
ajst-32481	223	17	and	and	CCONJ
ajst-32481	223	18	central	central	ADJ
ajst-32481	223	19	gaba	gaba	NOUN
ajst-32481	223	20	receptor	receptor	NOUN
ajst-32481	223	21	expression	expression	NOUN
ajst-32481	223	22	in	in	ADP
ajst-32481	223	23	a	a	DET
ajst-32481	223	24	mouse	mouse	NOUN
ajst-32481	223	25	via	via	ADP
ajst-32481	223	26	the	the	DET
ajst-32481	223	27	vagus	vagus	NOUN
ajst-32481	223	28	nerve	nerve	NOUN
ajst-32481	223	29	.	.	PUNCT
ajst-32481	224	1	proc	proc	PROPN
ajst-32481	224	2	.	.	PUNCT
ajst-32481	225	1	natl	natl	PROPN
ajst-32481	225	2	.	.	PUNCT
ajst-32481	226	1	acad	acad	PROPN
ajst-32481	226	2	.	.	PUNCT
ajst-32481	227	1	sci	sci	PROPN
ajst-32481	227	2	.	.	PUNCT
ajst-32481	227	3	u.s.a	u.s.a	PROPN
ajst-32481	227	4	.	.	PROPN
ajst-32481	227	5	108	108	NUM
ajst-32481	227	6	,	,	PUNCT
ajst-32481	227	7	16050–16055	16050–16055	NUM
ajst-32481	227	8	(	(	PUNCT
ajst-32481	227	9	2011	2011	NUM
ajst-32481	227	10	)	)	PUNCT
ajst-32481	227	11	.	.	PUNCT
ajst-32481	228	1	[	[	X
ajst-32481	228	2	30	30	NUM
ajst-32481	228	3	]	]	X
ajst-32481	228	4	bonaz	bonaz	PROPN
ajst-32481	228	5	,	,	PUNCT
ajst-32481	228	6	b.	b.	PROPN
ajst-32481	228	7	,	,	PUNCT
ajst-32481	228	8	sinniger	sinniger	NOUN
ajst-32481	228	9	,	,	PUNCT
ajst-32481	228	10	v.	v.	PROPN
ajst-32481	228	11	&	&	CCONJ
ajst-32481	228	12	pellissier	pellissier	PROPN
ajst-32481	228	13	,	,	PUNCT
ajst-32481	228	14	s.	s.	PROPN
ajst-32481	228	15	the	the	DET
ajst-32481	228	16	vagus	vagus	PROPN
ajst-32481	228	17	nerve	nerve	NOUN
ajst-32481	228	18	in	in	ADP
ajst-32481	228	19	the	the	DET
ajst-32481	228	20	neuro	neuro	NOUN
ajst-32481	228	21	-	-	PUNCT
ajst-32481	228	22	immune	immune	ADJ
ajst-32481	228	23	axis	axis	NOUN
ajst-32481	228	24	:	:	PUNCT
ajst-32481	228	25	implications	implication	NOUN
ajst-32481	228	26	in	in	ADP
ajst-32481	228	27	gastrointestinal	gastrointestinal	ADJ
ajst-32481	228	28	pathology	pathology	NOUN
ajst-32481	228	29	.	.	PUNCT
ajst-32481	229	1	front	front	ADJ
ajst-32481	229	2	.	.	PUNCT
ajst-32481	230	1	immunol	immunol	NOUN
ajst-32481	230	2	.	.	PUNCT
ajst-32481	231	1	8	8	NUM
ajst-32481	231	2	,	,	PUNCT
ajst-32481	231	3	1452	1452	NUM
ajst-32481	231	4	(	(	PUNCT
ajst-32481	231	5	2017	2017	NUM
ajst-32481	231	6	)	)	PUNCT
ajst-32481	231	7	.	.	PUNCT
ajst-32481	232	1	105	105	NUM
ajst-32481	233	1	[	[	X
ajst-32481	233	2	31	31	NUM
ajst-32481	233	3	]	]	PUNCT
ajst-32481	233	4	stilling	still	VERB
ajst-32481	233	5	,	,	PUNCT
ajst-32481	233	6	r.	r.	PROPN
ajst-32481	233	7	m.	m.	PROPN
ajst-32481	233	8	et	et	PROPN
ajst-32481	233	9	al	al	PROPN
ajst-32481	233	10	.	.	PUNCT
ajst-32481	234	1	the	the	DET
ajst-32481	234	2	neuropharmacology	neuropharmacology	NOUN
ajst-32481	234	3	of	of	ADP
ajst-32481	234	4	butyrate	butyrate	NOUN
ajst-32481	234	5	:	:	PUNCT
ajst-32481	234	6	the	the	DET
ajst-32481	234	7	bread	bread	NOUN
ajst-32481	234	8	and	and	CCONJ
ajst-32481	234	9	butter	butter	NOUN
ajst-32481	234	10	of	of	ADP
ajst-32481	234	11	the	the	DET
ajst-32481	234	12	microbiota	microbiota	NOUN
ajst-32481	234	13	–	–	PUNCT
ajst-32481	234	14	gut	gut	NOUN
ajst-32481	234	15	–	–	PUNCT
ajst-32481	234	16	brain	brain	NOUN
ajst-32481	234	17	axis	axis	NOUN
ajst-32481	234	18	?	?	PUNCT
ajst-32481	235	1	neurochem	neurochem	PROPN
ajst-32481	235	2	.	.	PUNCT
ajst-32481	236	1	int	int	NOUN
ajst-32481	236	2	.	.	PUNCT
ajst-32481	237	1	99	99	NUM
ajst-32481	237	2	,	,	PUNCT
ajst-32481	237	3	110–132	110–132	NUM
ajst-32481	237	4	(	(	PUNCT
ajst-32481	237	5	2016	2016	NUM
ajst-32481	237	6	)	)	PUNCT
ajst-32481	237	7	.	.	PUNCT
ajst-32481	238	1	[	[	X
ajst-32481	238	2	32	32	NUM
ajst-32481	238	3	]	]	PUNCT
ajst-32481	238	4	roth	roth	PROPN
ajst-32481	238	5	,	,	PUNCT
ajst-32481	238	6	w.	w.	PROPN
ajst-32481	238	7	,	,	PUNCT
ajst-32481	238	8	zadeh	zadeh	PROPN
ajst-32481	238	9	,	,	PUNCT
ajst-32481	238	10	k.	k.	PROPN
ajst-32481	238	11	,	,	PUNCT
ajst-32481	238	12	vekariya	vekariya	PROPN
ajst-32481	238	13	,	,	PUNCT
ajst-32481	238	14	r.	r.	PROPN
ajst-32481	238	15	,	,	PUNCT
ajst-32481	238	16	ge	ge	PROPN
ajst-32481	238	17	,	,	PUNCT
ajst-32481	238	18	y.	y.	PROPN
ajst-32481	238	19	&	&	CCONJ
ajst-32481	238	20	mohamadzadeh	mohamadzadeh	PROPN
ajst-32481	238	21	,	,	PUNCT
ajst-32481	238	22	m.	m.	NOUN
ajst-32481	238	23	tryptophan	tryptophan	NOUN
ajst-32481	238	24	metabolism	metabolism	NOUN
ajst-32481	238	25	and	and	CCONJ
ajst-32481	238	26	gut	gut	NOUN
ajst-32481	238	27	–	–	PUNCT
ajst-32481	238	28	brain	brain	NOUN
ajst-32481	238	29	homeostasis	homeostasis	NOUN
ajst-32481	238	30	.	.	PUNCT
ajst-32481	239	1	int	int	NOUN
ajst-32481	239	2	.	.	PUNCT
ajst-32481	240	1	j.	j.	PROPN
ajst-32481	240	2	mol	mol	PROPN
ajst-32481	240	3	.	.	PUNCT
ajst-32481	241	1	sci	sci	PROPN
ajst-32481	241	2	.	.	PROPN
ajst-32481	241	3	22	22	NUM
ajst-32481	241	4	,	,	PUNCT
ajst-32481	241	5	2973	2973	NUM
ajst-32481	241	6	(	(	PUNCT
ajst-32481	241	7	2021	2021	NUM
ajst-32481	241	8	)	)	PUNCT
ajst-32481	241	9	.	.	PUNCT
ajst-32481	242	1	[	[	X
ajst-32481	242	2	33	33	NUM
ajst-32481	242	3	]	]	X
ajst-32481	242	4	lps	lps	PROPN
ajst-32481	242	5	induces	induce	VERB
ajst-32481	242	6	intestinal	intestinal	ADJ
ajst-32481	242	7	tight	tight	ADJ
ajst-32481	242	8	junction	junction	NOUN
ajst-32481	242	9	permeability	permeability	NOUN
ajst-32481	242	10	in	in	ADP
ajst-32481	242	11	vitro	vitro	X
ajst-32481	242	12	and	and	CCONJ
ajst-32481	242	13	in	in	ADP
ajst-32481	242	14	vivo	vivo	NOUN
ajst-32481	242	15	by	by	ADP
ajst-32481	242	16	tlr4	tlr4	NOUN
ajst-32481	242	17	/	/	SYM
ajst-32481	242	18	cd14	cd14	PROPN
ajst-32481	242	19	expression	expression	NOUN
ajst-32481	242	20	.	.	PUNCT
ajst-32481	243	1	pubmed	pubmed	PROPN
ajst-32481	243	2	.	.	PUNCT
ajst-32481	244	1	https://pubmed.ncbi.nlm.nih.gov/23201091/.	https://pubmed.ncbi.nlm.nih.gov/23201091/.	PROPN
ajst-32481	245	1	[	[	X
ajst-32481	245	2	34	34	NUM
ajst-32481	245	3	]	]	X
ajst-32481	245	4	toledo	toledo	PROPN
ajst-32481	245	5	,	,	PUNCT
ajst-32481	245	6	m.	m.	NOUN
ajst-32481	245	7	et	et	PROPN
ajst-32481	245	8	al	al	PROPN
ajst-32481	245	9	.	.	PROPN
ajst-32481	245	10	rapid	rapid	ADJ
ajst-32481	245	11	modulation	modulation	NOUN
ajst-32481	245	12	of	of	ADP
ajst-32481	245	13	gut	gut	ADJ
ajst-32481	245	14	microbiota	microbiota	NOUN
ajst-32481	245	15	composition	composition	NOUN
ajst-32481	245	16	by	by	ADP
ajst-32481	245	17	hypothalamic	hypothalamic	ADJ
ajst-32481	245	18	circuits	circuit	NOUN
ajst-32481	245	19	in	in	ADP
ajst-32481	245	20	mice	mouse	NOUN
ajst-32481	245	21	.	.	PUNCT
ajst-32481	246	1	nat	nat	NOUN
ajst-32481	246	2	.	.	PUNCT
ajst-32481	247	1	metab	metab	PROPN
ajst-32481	247	2	.	.	PUNCT
ajst-32481	248	1	7	7	NUM
ajst-32481	248	2	,	,	PUNCT
ajst-32481	248	3	1123–1135	1123–1135	NUM
ajst-32481	248	4	(	(	PUNCT
ajst-32481	248	5	2025	2025	NUM
ajst-32481	248	6	)	)	PUNCT
ajst-32481	248	7	.	.	PUNCT
ajst-32481	249	1	[	[	X
ajst-32481	249	2	35	35	NUM
ajst-32481	249	3	]	]	X
ajst-32481	249	4	kowalski	kowalski	PROPN
ajst-32481	249	5	,	,	PUNCT
ajst-32481	249	6	k.	k.	PROPN
ajst-32481	249	7	&	&	CCONJ
ajst-32481	249	8	mulak	mulak	PROPN
ajst-32481	249	9	,	,	PUNCT
ajst-32481	249	10	a.	a.	NOUN
ajst-32481	249	11	brain	brain	NOUN
ajst-32481	249	12	–	–	PUNCT
ajst-32481	249	13	gut	gut	ADJ
ajst-32481	249	14	–	–	PUNCT
ajst-32481	249	15	microbiota	microbiota	NOUN
ajst-32481	249	16	axis	axis	NOUN
ajst-32481	249	17	in	in	ADP
ajst-32481	249	18	alzheimer	alzheimer	PROPN
ajst-32481	249	19	’s	’s	PART
ajst-32481	249	20	disease	disease	NOUN
ajst-32481	249	21	.	.	PUNCT
ajst-32481	250	1	j.	j.	PROPN
ajst-32481	250	2	neurogastroenterol	neurogastroenterol	PROPN
ajst-32481	250	3	.	.	PUNCT
ajst-32481	251	1	motil	motil	PROPN
ajst-32481	251	2	.	.	PROPN
ajst-32481	252	1	25	25	NUM
ajst-32481	252	2	,	,	PUNCT
ajst-32481	252	3	48–60	48–60	NUM
ajst-32481	252	4	(	(	PUNCT
ajst-32481	252	5	2019	2019	NUM
ajst-32481	252	6	)	)	PUNCT
ajst-32481	252	7	.	.	PUNCT
ajst-32481	253	1	[	[	X
ajst-32481	253	2	36	36	NUM
ajst-32481	253	3	]	]	X
ajst-32481	253	4	yadav	yadav	PROPN
ajst-32481	253	5	,	,	PUNCT
ajst-32481	253	6	p.	p.	NOUN
ajst-32481	253	7	et	et	NOUN
ajst-32481	254	1	al	al	PROPN
ajst-32481	254	2	.	.	PUNCT
ajst-32481	254	3	implications	implication	NOUN
ajst-32481	254	4	of	of	ADP
ajst-32481	254	5	microorganisms	microorganism	NOUN
ajst-32481	254	6	in	in	ADP
ajst-32481	254	7	alzheimer	alzheimer	PROPN
ajst-32481	254	8	’s	’s	PART
ajst-32481	254	9	disease	disease	NOUN
ajst-32481	254	10	.	.	PUNCT
ajst-32481	255	1	curr	curr	PROPN
ajst-32481	255	2	.	.	PUNCT
ajst-32481	256	1	issues	issues	PROPN
ajst-32481	256	2	mol	mol	PROPN
ajst-32481	256	3	.	.	PUNCT
ajst-32481	257	1	biol	biol	PROPN
ajst-32481	257	2	.	.	PUNCT
ajst-32481	258	1	44	44	NUM
ajst-32481	258	2	,	,	PUNCT
ajst-32481	258	3	4584	4584	NUM
ajst-32481	258	4	–	–	PUNCT
ajst-32481	258	5	4615	4615	NUM
ajst-32481	258	6	(	(	PUNCT
ajst-32481	258	7	2022	2022	NUM
ajst-32481	258	8	)	)	PUNCT
ajst-32481	258	9	.	.	PUNCT
ajst-32481	259	1	[	[	X
ajst-32481	259	2	37	37	NUM
ajst-32481	259	3	]	]	SYM
ajst-32481	259	4	ferreiro	ferreiro	NOUN
ajst-32481	259	5	,	,	PUNCT
ajst-32481	259	6	a.	a.	PROPN
ajst-32481	259	7	l.	l.	PROPN
ajst-32481	259	8	et	et	PROPN
ajst-32481	259	9	al	al	PROPN
ajst-32481	259	10	.	.	PUNCT
ajst-32481	260	1	gut	gut	NOUN
ajst-32481	260	2	microbiome	microbiome	ADJ
ajst-32481	260	3	composition	composition	NOUN
ajst-32481	260	4	may	may	AUX
ajst-32481	260	5	be	be	AUX
ajst-32481	260	6	an	an	DET
ajst-32481	260	7	indicator	indicator	NOUN
ajst-32481	260	8	of	of	ADP
ajst-32481	260	9	preclinical	preclinical	ADJ
ajst-32481	260	10	alzheimer	alzheimer	PROPN
ajst-32481	260	11	’s	’s	PART
ajst-32481	260	12	disease	disease	NOUN
ajst-32481	260	13	.	.	PUNCT
ajst-32481	261	1	sci	sci	PROPN
ajst-32481	261	2	.	.	PROPN
ajst-32481	261	3	transl	transl	PROPN
ajst-32481	261	4	.	.	PUNCT
ajst-32481	262	1	med	med	PROPN
ajst-32481	262	2	.	.	PROPN
ajst-32481	262	3	15	15	NUM
ajst-32481	262	4	,	,	PUNCT
ajst-32481	262	5	eabo2984	eabo2984	PROPN
ajst-32481	262	6	(	(	PUNCT
ajst-32481	262	7	2023	2023	NUM
ajst-32481	262	8	)	)	PUNCT
ajst-32481	262	9	.	.	PUNCT
ajst-32481	263	1	[	[	X
ajst-32481	263	2	38	38	NUM
ajst-32481	263	3	]	]	PUNCT
ajst-32481	263	4	zha	zha	PROPN
ajst-32481	263	5	,	,	PUNCT
ajst-32481	263	6	x.	x.	NOUN
ajst-32481	263	7	et	et	PROPN
ajst-32481	264	1	al	al	PROPN
ajst-32481	264	2	.	.	PUNCT
ajst-32481	265	1	microbiota	microbiota	NOUN
ajst-32481	265	2	-	-	PUNCT
ajst-32481	265	3	derived	derive	VERB
ajst-32481	265	4	lysophosphatidylcholine	lysophosphatidylcholine	NOUN
ajst-32481	265	5	alleviates	alleviate	VERB
ajst-32481	265	6	alzheimer	alzheimer	PROPN
ajst-32481	265	7	’s	’s	PART
ajst-32481	265	8	disease	disease	NOUN
ajst-32481	265	9	pathology	pathology	NOUN
ajst-32481	265	10	via	via	ADP
ajst-32481	265	11	suppressing	suppress	VERB
ajst-32481	265	12	ferroptosis	ferroptosis	NOUN
ajst-32481	265	13	.	.	PUNCT
ajst-32481	266	1	cell	cell	NOUN
ajst-32481	266	2	metab	metab	NOUN
ajst-32481	266	3	.	.	PUNCT
ajst-32481	267	1	37	37	NUM
ajst-32481	267	2	,	,	PUNCT
ajst-32481	267	3	169–186.e9	169–186.e9	NUM
ajst-32481	267	4	(	(	PUNCT
ajst-32481	267	5	2025	2025	NUM
ajst-32481	267	6	)	)	PUNCT
ajst-32481	267	7	.	.	PUNCT
ajst-32481	268	1	[	[	X
ajst-32481	268	2	39	39	NUM
ajst-32481	268	3	]	]	X
ajst-32481	268	4	liang	liang	PROPN
ajst-32481	268	5	,	,	PUNCT
ajst-32481	268	6	y.	y.	PROPN
ajst-32481	268	7	et	et	PROPN
ajst-32481	268	8	al	al	PROPN
ajst-32481	268	9	.	.	PUNCT
ajst-32481	269	1	the	the	DET
ajst-32481	269	2	link	link	NOUN
ajst-32481	269	3	between	between	ADP
ajst-32481	269	4	gut	gut	NOUN
ajst-32481	269	5	microbiome	microbiome	NOUN
ajst-32481	269	6	and	and	CCONJ
ajst-32481	269	7	alzheimer	alzheimer	PROPN
ajst-32481	269	8	’s	’s	PART
ajst-32481	269	9	disease	disease	NOUN
ajst-32481	269	10	:	:	PUNCT
ajst-32481	269	11	from	from	ADP
ajst-32481	269	12	the	the	DET
ajst-32481	269	13	perspective	perspective	NOUN
ajst-32481	269	14	of	of	ADP
ajst-32481	269	15	revised	revise	VERB
ajst-32481	269	16	diagnostic	diagnostic	ADJ
ajst-32481	269	17	and	and	CCONJ
ajst-32481	269	18	staging	staging	NOUN
ajst-32481	269	19	criteria	criterion	NOUN
ajst-32481	269	20	.	.	PUNCT
ajst-32481	270	1	alzheimer	alzheimer	PROPN
ajst-32481	270	2	’s	’s	PART
ajst-32481	270	3	dement	dement	PROPN
ajst-32481	270	4	.	.	PUNCT
ajst-32481	271	1	20	20	NUM
ajst-32481	271	2	,	,	PUNCT
ajst-32481	271	3	5771–5788	5771–5788	NUM
ajst-32481	271	4	(	(	PUNCT
ajst-32481	271	5	2024	2024	NUM
ajst-32481	271	6	)	)	PUNCT
ajst-32481	271	7	.	.	PUNCT
ajst-32481	272	1	[	[	X
ajst-32481	272	2	40	40	NUM
ajst-32481	272	3	]	]	SYM
ajst-32481	272	4	yang	yang	PROPN
ajst-32481	272	5	,	,	PUNCT
ajst-32481	272	6	c.	c.	PROPN
ajst-32481	272	7	et	et	PROPN
ajst-32481	272	8	al	al	PROPN
ajst-32481	272	9	.	.	PUNCT
ajst-32481	272	10	synbiotics	synbiotic	NOUN
ajst-32481	272	11	of	of	ADP
ajst-32481	272	12	lactobacillus	lactobacillus	NOUN
ajst-32481	272	13	suilingensis	suilingensis	NOUN
ajst-32481	272	14	and	and	CCONJ
ajst-32481	272	15	inulin	inulin	NOUN
ajst-32481	272	16	alleviate	alleviate	VERB
ajst-32481	272	17	cognitive	cognitive	ADJ
ajst-32481	272	18	impairment	impairment	NOUN
ajst-32481	272	19	via	via	ADP
ajst-32481	272	20	indole-3	indole-3	NOUN
ajst-32481	272	21	-	-	PUNCT
ajst-32481	272	22	lactic	lactic	ADJ
ajst-32481	272	23	acid	acid	NOUN
ajst-32481	272	24	metabolism	metabolism	NOUN
ajst-32481	272	25	in	in	ADP
ajst-32481	272	26	female	female	ADJ
ajst-32481	272	27	ad	ad	NOUN
ajst-32481	272	28	mice	mouse	NOUN
ajst-32481	272	29	.	.	PUNCT
ajst-32481	273	1	alzheimer	alzheimer	PROPN
ajst-32481	273	2	’s	’s	PART
ajst-32481	273	3	dement	dement	PROPN
ajst-32481	273	4	.	.	PUNCT
ajst-32481	274	1	21	21	NUM
ajst-32481	274	2	,	,	PUNCT
ajst-32481	274	3	e70406	e70406	VERB
ajst-32481	274	4	(	(	PUNCT
ajst-32481	274	5	2025	2025	NUM
ajst-32481	274	6	)	)	PUNCT
ajst-32481	274	7	.	.	PUNCT
ajst-32481	275	1	[	[	X
ajst-32481	275	2	41	41	NUM
ajst-32481	275	3	]	]	X
ajst-32481	275	4	zha	zha	PROPN
ajst-32481	275	5	,	,	PUNCT
ajst-32481	275	6	x.	x.	NOUN
ajst-32481	275	7	et	et	PROPN
ajst-32481	276	1	al	al	PROPN
ajst-32481	276	2	.	.	PUNCT
ajst-32481	277	1	microbiota	microbiota	NOUN
ajst-32481	277	2	-	-	PUNCT
ajst-32481	277	3	derived	derive	VERB
ajst-32481	277	4	lysophosphatidylcholine	lysophosphatidylcholine	NOUN
ajst-32481	277	5	alleviates	alleviate	VERB
ajst-32481	277	6	alzheimer	alzheimer	PROPN
ajst-32481	277	7	’s	’s	PART
ajst-32481	277	8	disease	disease	NOUN
ajst-32481	277	9	pathology	pathology	NOUN
ajst-32481	277	10	via	via	ADP
ajst-32481	277	11	suppressing	suppress	VERB
ajst-32481	277	12	ferroptosis	ferroptosis	NOUN
ajst-32481	277	13	.	.	PUNCT
ajst-32481	278	1	cell	cell	NOUN
ajst-32481	278	2	metab	metab	NOUN
ajst-32481	278	3	.	.	PUNCT
ajst-32481	279	1	37	37	NUM
ajst-32481	279	2	,	,	PUNCT
ajst-32481	279	3	169–186.e9	169–186.e9	NUM
ajst-32481	279	4	(	(	PUNCT
ajst-32481	279	5	2025	2025	NUM
ajst-32481	279	6	)	)	PUNCT
ajst-32481	279	7	.	.	PUNCT