id	sid	tid	token	lemma	pos
ajst-32482	1	1	106	106	NUM
ajst-32482	1	2	immune	immune	ADJ
ajst-32482	1	3	checkpoint	checkpoint	NOUN
ajst-32482	1	4	inhibitors	inhibitor	NOUN
ajst-32482	1	5	:	:	PUNCT
ajst-32482	1	6	an	an	DET
ajst-32482	1	7	innovative	innovative	ADJ
ajst-32482	1	8	direction	direction	NOUN
ajst-32482	1	9	in	in	ADP
ajst-32482	1	10	cancer	cancer	NOUN
ajst-32482	1	11	immunotherapy	immunotherapy	NOUN
ajst-32482	1	12	xinrun	xinrun	PROPN
ajst-32482	1	13	xie	xie	PROPN
ajst-32482	1	14	guangdong	guangdong	PROPN
ajst-32482	1	15	country	country	PROPN
ajst-32482	1	16	garden	garden	PROPN
ajst-32482	1	17	school	school	PROPN
ajst-32482	1	18	,	,	PUNCT
ajst-32482	1	19	foshan	foshan	PROPN
ajst-32482	1	20	,	,	PUNCT
ajst-32482	1	21	guangdong	guangdong	PROPN
ajst-32482	1	22	,	,	PUNCT
ajst-32482	1	23	china	china	PROPN
ajst-32482	1	24	13823020197@139.com	13823020197@139.com	NUM
ajst-32482	1	25	abstract	abstract	ADJ
ajst-32482	1	26	.	.	PUNCT
ajst-32482	2	1	immune	immune	ADJ
ajst-32482	2	2	checkpoint	checkpoint	NOUN
ajst-32482	2	3	inhibitors	inhibitor	NOUN
ajst-32482	2	4	(	(	PUNCT
ajst-32482	2	5	icis	icis	NOUN
ajst-32482	2	6	)	)	PUNCT
ajst-32482	2	7	are	be	AUX
ajst-32482	2	8	a	a	DET
ajst-32482	2	9	type	type	NOUN
ajst-32482	2	10	of	of	ADP
ajst-32482	2	11	immunotherapy	immunotherapy	NOUN
ajst-32482	2	12	.	.	PUNCT
ajst-32482	3	1	they	they	PRON
ajst-32482	3	2	work	work	VERB
ajst-32482	3	3	by	by	ADP
ajst-32482	3	4	blocking	block	VERB
ajst-32482	3	5	certain	certain	ADJ
ajst-32482	3	6	inhibitory	inhibitory	ADJ
ajst-32482	3	7	pathways	pathway	NOUN
ajst-32482	3	8	in	in	ADP
ajst-32482	3	9	the	the	DET
ajst-32482	3	10	body	body	NOUN
ajst-32482	3	11	,	,	PUNCT
ajst-32482	3	12	like	like	ADP
ajst-32482	3	13	pd-1	pd-1	ADP
ajst-32482	3	14	/	/	SYM
ajst-32482	3	15	pd	pd	NOUN
ajst-32482	3	16	-	-	PROPN
ajst-32482	3	17	l1	l1	PROPN
ajst-32482	3	18	and	and	CCONJ
ajst-32482	3	19	ctla-4	ctla-4	PROPN
ajst-32482	3	20	,	,	PUNCT
ajst-32482	3	21	which	which	PRON
ajst-32482	3	22	helps	help	VERB
ajst-32482	3	23	reactivate	reactivate	VERB
ajst-32482	3	24	the	the	DET
ajst-32482	3	25	immune	immune	ADJ
ajst-32482	3	26	system	system	NOUN
ajst-32482	3	27	’s	’s	PART
ajst-32482	3	28	t	t	PROPN
ajst-32482	3	29	cells	cell	NOUN
ajst-32482	3	30	to	to	PART
ajst-32482	3	31	find	find	VERB
ajst-32482	3	32	and	and	CCONJ
ajst-32482	3	33	attack	attack	VERB
ajst-32482	3	34	cancer	cancer	NOUN
ajst-32482	3	35	cells	cell	NOUN
ajst-32482	3	36	.	.	PUNCT
ajst-32482	4	1	current	current	ADJ
ajst-32482	4	2	studies	study	NOUN
ajst-32482	4	3	primarily	primarily	ADV
ajst-32482	4	4	focus	focus	VERB
ajst-32482	4	5	on	on	ADP
ajst-32482	4	6	key	key	ADJ
ajst-32482	4	7	targets	target	NOUN
ajst-32482	4	8	,	,	PUNCT
ajst-32482	4	9	including	include	VERB
ajst-32482	4	10	pd-1	pd-1	ADP
ajst-32482	4	11	,	,	PUNCT
ajst-32482	4	12	pd	pd	PROPN
ajst-32482	4	13	-	-	PROPN
ajst-32482	4	14	l1	l1	PROPN
ajst-32482	4	15	,	,	PUNCT
ajst-32482	4	16	and	and	CCONJ
ajst-32482	4	17	ctla-4	ctla-4	NOUN
ajst-32482	4	18	.	.	PUNCT
ajst-32482	5	1	these	these	DET
ajst-32482	5	2	treatments	treatment	NOUN
ajst-32482	5	3	are	be	AUX
ajst-32482	5	4	used	use	VERB
ajst-32482	5	5	for	for	ADP
ajst-32482	5	6	various	various	ADJ
ajst-32482	5	7	cancers	cancer	NOUN
ajst-32482	5	8	,	,	PUNCT
ajst-32482	5	9	including	include	VERB
ajst-32482	5	10	melanoma	melanoma	NOUN
ajst-32482	5	11	,	,	PUNCT
ajst-32482	5	12	non	non	ADJ
ajst-32482	5	13	-	-	ADJ
ajst-32482	5	14	small	small	ADJ
ajst-32482	5	15	-	-	PUNCT
ajst-32482	5	16	cell	cell	NOUN
ajst-32482	5	17	lung	lung	NOUN
ajst-32482	5	18	cancer	cancer	NOUN
ajst-32482	5	19	,	,	PUNCT
ajst-32482	5	20	kidney	kidney	NOUN
ajst-32482	5	21	cancer	cancer	NOUN
ajst-32482	5	22	,	,	PUNCT
ajst-32482	5	23	and	and	CCONJ
ajst-32482	5	24	hodgkin	hodgkin	PROPN
ajst-32482	5	25	lymphoma	lymphoma	NOUN
ajst-32482	5	26	,	,	PUNCT
ajst-32482	5	27	and	and	CCONJ
ajst-32482	5	28	researchers	researcher	NOUN
ajst-32482	5	29	are	be	AUX
ajst-32482	5	30	also	also	ADV
ajst-32482	5	31	testing	test	VERB
ajst-32482	5	32	them	they	PRON
ajst-32482	5	33	on	on	ADP
ajst-32482	5	34	other	other	ADJ
ajst-32482	5	35	types	type	NOUN
ajst-32482	5	36	like	like	ADP
ajst-32482	5	37	triple	triple	ADJ
ajst-32482	5	38	-	-	PUNCT
ajst-32482	5	39	negative	negative	ADJ
ajst-32482	5	40	breast	breast	NOUN
ajst-32482	5	41	cancer	cancer	NOUN
ajst-32482	5	42	and	and	CCONJ
ajst-32482	5	43	brain	brain	NOUN
ajst-32482	5	44	tumors	tumor	NOUN
ajst-32482	5	45	.	.	PUNCT
ajst-32482	6	1	there	there	PRON
ajst-32482	6	2	have	have	AUX
ajst-32482	6	3	been	be	AUX
ajst-32482	6	4	significant	significant	ADJ
ajst-32482	6	5	advances	advance	NOUN
ajst-32482	6	6	:	:	PUNCT
ajst-32482	6	7	several	several	ADJ
ajst-32482	6	8	icis	icis	PROPN
ajst-32482	6	9	,	,	PUNCT
ajst-32482	6	10	such	such	ADJ
ajst-32482	6	11	as	as	ADP
ajst-32482	6	12	pembrolizumab	pembrolizumab	NOUN
ajst-32482	6	13	,	,	PUNCT
ajst-32482	6	14	nivolumab	nivolumab	NOUN
ajst-32482	6	15	,	,	PUNCT
ajst-32482	6	16	and	and	CCONJ
ajst-32482	6	17	ipilimumab	ipilimumab	ADV
ajst-32482	6	18	,	,	PUNCT
ajst-32482	6	19	have	have	AUX
ajst-32482	6	20	been	be	AUX
ajst-32482	6	21	approved	approve	VERB
ajst-32482	6	22	for	for	ADP
ajst-32482	6	23	use	use	NOUN
ajst-32482	6	24	,	,	PUNCT
ajst-32482	6	25	becoming	become	VERB
ajst-32482	6	26	standard	standard	ADJ
ajst-32482	6	27	treatments	treatment	NOUN
ajst-32482	6	28	for	for	ADP
ajst-32482	6	29	many	many	ADJ
ajst-32482	6	30	advanced	advanced	ADJ
ajst-32482	6	31	cancers	cancer	NOUN
ajst-32482	6	32	and	and	CCONJ
ajst-32482	6	33	helping	help	VERB
ajst-32482	6	34	patients	patient	NOUN
ajst-32482	6	35	live	live	VERB
ajst-32482	6	36	longer	long	ADV
ajst-32482	6	37	,	,	PUNCT
ajst-32482	6	38	even	even	ADV
ajst-32482	6	39	achieving	achieve	VERB
ajst-32482	6	40	long	long	ADJ
ajst-32482	6	41	-	-	PUNCT
ajst-32482	6	42	term	term	NOUN
ajst-32482	6	43	remission	remission	NOUN
ajst-32482	6	44	in	in	ADP
ajst-32482	6	45	some	some	DET
ajst-32482	6	46	cases	case	NOUN
ajst-32482	6	47	.	.	PUNCT
ajst-32482	7	1	however	however	ADV
ajst-32482	7	2	,	,	PUNCT
ajst-32482	7	3	there	there	PRON
ajst-32482	7	4	are	be	VERB
ajst-32482	7	5	problems	problem	NOUN
ajst-32482	7	6	:	:	PUNCT
ajst-32482	7	7	some	some	DET
ajst-32482	7	8	tumors	tumor	NOUN
ajst-32482	7	9	resist	resist	VERB
ajst-32482	7	10	icis	icis	NOUN
ajst-32482	7	11	from	from	ADP
ajst-32482	7	12	the	the	DET
ajst-32482	7	13	start	start	NOUN
ajst-32482	7	14	or	or	CCONJ
ajst-32482	7	15	develop	develop	VERB
ajst-32482	7	16	resistance	resistance	NOUN
ajst-32482	7	17	later	later	ADV
ajst-32482	7	18	,	,	PUNCT
ajst-32482	7	19	making	make	VERB
ajst-32482	7	20	the	the	DET
ajst-32482	7	21	treatments	treatment	NOUN
ajst-32482	7	22	less	less	ADV
ajst-32482	7	23	effective	effective	ADJ
ajst-32482	7	24	.	.	PUNCT
ajst-32482	8	1	additionally	additionally	ADV
ajst-32482	8	2	,	,	PUNCT
ajst-32482	8	3	icis	icis	PROPN
ajst-32482	8	4	can	can	AUX
ajst-32482	8	5	cause	cause	VERB
ajst-32482	8	6	immune	immune	NOUN
ajst-32482	8	7	-	-	PUNCT
ajst-32482	8	8	related	relate	VERB
ajst-32482	8	9	side	side	NOUN
ajst-32482	8	10	effects	effect	NOUN
ajst-32482	8	11	because	because	SCONJ
ajst-32482	8	12	they	they	PRON
ajst-32482	8	13	overactivate	overactivate	VERB
ajst-32482	8	14	the	the	DET
ajst-32482	8	15	immune	immune	ADJ
ajst-32482	8	16	system	system	NOUN
ajst-32482	8	17	,	,	PUNCT
ajst-32482	8	18	which	which	PRON
ajst-32482	8	19	can	can	AUX
ajst-32482	8	20	affect	affect	VERB
ajst-32482	8	21	the	the	DET
ajst-32482	8	22	skin	skin	NOUN
ajst-32482	8	23	,	,	PUNCT
ajst-32482	8	24	digestive	digestive	ADJ
ajst-32482	8	25	system	system	NOUN
ajst-32482	8	26	,	,	PUNCT
ajst-32482	8	27	or	or	CCONJ
ajst-32482	8	28	hormone	hormone	NOUN
ajst-32482	8	29	-	-	PUNCT
ajst-32482	8	30	producing	produce	VERB
ajst-32482	8	31	glands	gland	NOUN
ajst-32482	8	32	,	,	PUNCT
ajst-32482	8	33	with	with	ADP
ajst-32482	8	34	rare	rare	ADJ
ajst-32482	8	35	but	but	CCONJ
ajst-32482	8	36	serious	serious	ADJ
ajst-32482	8	37	issues	issue	NOUN
ajst-32482	8	38	,	,	PUNCT
ajst-32482	8	39	such	such	ADJ
ajst-32482	8	40	as	as	ADP
ajst-32482	8	41	heart	heart	NOUN
ajst-32482	8	42	inflammation	inflammation	NOUN
ajst-32482	8	43	.	.	PUNCT
ajst-32482	9	1	future	future	ADJ
ajst-32482	9	2	research	research	NOUN
ajst-32482	9	3	will	will	AUX
ajst-32482	9	4	aim	aim	VERB
ajst-32482	9	5	to	to	PART
ajst-32482	9	6	find	find	VERB
ajst-32482	9	7	ways	way	NOUN
ajst-32482	9	8	to	to	PART
ajst-32482	9	9	overcome	overcome	VERB
ajst-32482	9	10	resistance	resistance	NOUN
ajst-32482	9	11	and	and	CCONJ
ajst-32482	9	12	manage	manage	VERB
ajst-32482	9	13	these	these	DET
ajst-32482	9	14	side	side	NOUN
ajst-32482	9	15	effects	effect	NOUN
ajst-32482	9	16	better	well	ADV
ajst-32482	9	17	,	,	PUNCT
ajst-32482	9	18	so	so	ADV
ajst-32482	9	19	icis	icis	PROPN
ajst-32482	9	20	can	can	AUX
ajst-32482	9	21	be	be	AUX
ajst-32482	9	22	safer	safe	ADJ
ajst-32482	9	23	and	and	CCONJ
ajst-32482	9	24	more	more	ADV
ajst-32482	9	25	effective	effective	ADJ
ajst-32482	9	26	.	.	PUNCT
ajst-32482	10	1	keywords	keyword	NOUN
ajst-32482	10	2	:	:	PUNCT
ajst-32482	10	3	immune	immune	ADJ
ajst-32482	10	4	checkpoint	checkpoint	NOUN
ajst-32482	10	5	inhibitors	inhibitor	NOUN
ajst-32482	10	6	;	;	PUNCT
ajst-32482	10	7	cancer	cancer	NOUN
ajst-32482	10	8	immunotherapy	immunotherapy	NOUN
ajst-32482	10	9	;	;	PUNCT
ajst-32482	10	10	pd	pd	PROPN
ajst-32482	10	11	1	1	NUM
ajst-32482	10	12	/	/	SYM
ajst-32482	10	13	pd	pd	PROPN
ajst-32482	10	14	l1	l1	PROPN
ajst-32482	10	15	;	;	PUNCT
ajst-32482	10	16	ctla-4	ctla-4	NUM
ajst-32482	10	17	;	;	PUNCT
ajst-32482	10	18	immune	immune	NOUN
ajst-32482	10	19	-	-	PUNCT
ajst-32482	10	20	related	relate	VERB
ajst-32482	10	21	side	side	NOUN
ajst-32482	10	22	effects	effect	NOUN
ajst-32482	10	23	.	.	PUNCT
ajst-32482	11	1	1	1	X
ajst-32482	11	2	.	.	X
ajst-32482	11	3	introduction	introduction	NOUN
ajst-32482	11	4	cancer	cancer	NOUN
ajst-32482	11	5	continues	continue	VERB
ajst-32482	11	6	to	to	PART
ajst-32482	11	7	be	be	AUX
ajst-32482	11	8	one	one	NUM
ajst-32482	11	9	of	of	ADP
ajst-32482	11	10	the	the	DET
ajst-32482	11	11	most	most	ADV
ajst-32482	11	12	lethal	lethal	ADJ
ajst-32482	11	13	diseases	disease	NOUN
ajst-32482	11	14	globally	globally	ADV
ajst-32482	11	15	.	.	PUNCT
ajst-32482	12	1	despite	despite	SCONJ
ajst-32482	12	2	advances	advance	NOUN
ajst-32482	12	3	in	in	ADP
ajst-32482	12	4	treatment	treatment	NOUN
ajst-32482	12	5	strategies	strategy	NOUN
ajst-32482	12	6	,	,	PUNCT
ajst-32482	12	7	many	many	ADJ
ajst-32482	12	8	cancer	cancer	NOUN
ajst-32482	12	9	patients	patient	NOUN
ajst-32482	12	10	still	still	ADV
ajst-32482	12	11	face	face	VERB
ajst-32482	12	12	poor	poor	ADJ
ajst-32482	12	13	outcomes	outcome	NOUN
ajst-32482	12	14	from	from	ADP
ajst-32482	12	15	traditional	traditional	ADJ
ajst-32482	12	16	therapies	therapy	NOUN
ajst-32482	12	17	like	like	ADP
ajst-32482	12	18	chemotherapy	chemotherapy	NOUN
ajst-32482	12	19	and	and	CCONJ
ajst-32482	12	20	radiation	radiation	NOUN
ajst-32482	12	21	.	.	PUNCT
ajst-32482	13	1	traditional	traditional	ADJ
ajst-32482	13	2	cancer	cancer	NOUN
ajst-32482	13	3	treatment	treatment	NOUN
ajst-32482	13	4	methods	method	NOUN
ajst-32482	13	5	mainly	mainly	ADV
ajst-32482	13	6	include	include	VERB
ajst-32482	13	7	surgery	surgery	NOUN
ajst-32482	13	8	,	,	PUNCT
ajst-32482	13	9	chemotherapy	chemotherapy	NOUN
ajst-32482	13	10	,	,	PUNCT
ajst-32482	13	11	and	and	CCONJ
ajst-32482	13	12	radiotherapy	radiotherapy	NOUN
ajst-32482	13	13	.	.	PUNCT
ajst-32482	14	1	surgery	surgery	NOUN
ajst-32482	14	2	aims	aim	VERB
ajst-32482	14	3	to	to	PART
ajst-32482	14	4	treat	treat	VERB
ajst-32482	14	5	cancer	cancer	NOUN
ajst-32482	14	6	by	by	ADP
ajst-32482	14	7	removing	remove	VERB
ajst-32482	14	8	tumor	tumor	NOUN
ajst-32482	14	9	tissues	tissue	NOUN
ajst-32482	14	10	,	,	PUNCT
ajst-32482	14	11	which	which	PRON
ajst-32482	14	12	is	be	AUX
ajst-32482	14	13	suitable	suitable	ADJ
ajst-32482	14	14	for	for	ADP
ajst-32482	14	15	patients	patient	NOUN
ajst-32482	14	16	with	with	ADP
ajst-32482	14	17	solid	solid	ADJ
ajst-32482	14	18	tumors	tumor	NOUN
ajst-32482	14	19	that	that	PRON
ajst-32482	14	20	have	have	AUX
ajst-32482	14	21	not	not	PART
ajst-32482	14	22	metastasized	metastasize	VERB
ajst-32482	14	23	extensively	extensively	ADV
ajst-32482	14	24	.	.	PUNCT
ajst-32482	15	1	however	however	ADV
ajst-32482	15	2	,	,	PUNCT
ajst-32482	15	3	it	it	PRON
ajst-32482	15	4	is	be	AUX
ajst-32482	15	5	ineffective	ineffective	ADJ
ajst-32482	15	6	for	for	ADP
ajst-32482	15	7	tiny	tiny	ADJ
ajst-32482	15	8	metastatic	metastatic	ADJ
ajst-32482	15	9	lesions	lesion	NOUN
ajst-32482	15	10	or	or	CCONJ
ajst-32482	15	11	hematological	hematological	ADJ
ajst-32482	15	12	tumors	tumor	NOUN
ajst-32482	15	13	.	.	PUNCT
ajst-32482	16	1	there	there	PRON
ajst-32482	16	2	may	may	AUX
ajst-32482	16	3	also	also	ADV
ajst-32482	16	4	be	be	AUX
ajst-32482	16	5	a	a	DET
ajst-32482	16	6	risk	risk	NOUN
ajst-32482	16	7	of	of	ADP
ajst-32482	16	8	recurrence	recurrence	NOUN
ajst-32482	16	9	after	after	ADP
ajst-32482	16	10	surgery	surgery	NOUN
ajst-32482	16	11	,	,	PUNCT
ajst-32482	16	12	and	and	CCONJ
ajst-32482	16	13	it	it	PRON
ajst-32482	16	14	may	may	AUX
ajst-32482	16	15	cause	cause	VERB
ajst-32482	16	16	trauma	trauma	NOUN
ajst-32482	16	17	to	to	ADP
ajst-32482	16	18	the	the	DET
ajst-32482	16	19	patient	patient	NOUN
ajst-32482	16	20	's	's	PART
ajst-32482	16	21	body	body	NOUN
ajst-32482	16	22	,	,	PUNCT
ajst-32482	16	23	affecting	affect	VERB
ajst-32482	16	24	their	their	PRON
ajst-32482	16	25	quality	quality	NOUN
ajst-32482	16	26	of	of	ADP
ajst-32482	16	27	life	life	NOUN
ajst-32482	16	28	.	.	PUNCT
ajst-32482	17	1	chemotherapy	chemotherapy	NOUN
ajst-32482	17	2	utilizes	utilize	VERB
ajst-32482	17	3	cytotoxic	cytotoxic	ADJ
ajst-32482	17	4	drugs	drug	NOUN
ajst-32482	17	5	to	to	PART
ajst-32482	17	6	target	target	VERB
ajst-32482	17	7	and	and	CCONJ
ajst-32482	17	8	kill	kill	VERB
ajst-32482	17	9	cancer	cancer	NOUN
ajst-32482	17	10	cells	cell	NOUN
ajst-32482	17	11	.	.	PUNCT
ajst-32482	18	1	while	while	SCONJ
ajst-32482	18	2	these	these	DET
ajst-32482	18	3	drugs	drug	NOUN
ajst-32482	18	4	target	target	VERB
ajst-32482	18	5	cancer	cancer	NOUN
ajst-32482	18	6	cells	cell	NOUN
ajst-32482	18	7	,	,	PUNCT
ajst-32482	18	8	they	they	PRON
ajst-32482	18	9	also	also	ADV
ajst-32482	18	10	harm	harm	VERB
ajst-32482	18	11	normal	normal	ADJ
ajst-32482	18	12	cells	cell	NOUN
ajst-32482	18	13	that	that	PRON
ajst-32482	18	14	divide	divide	VERB
ajst-32482	18	15	rapidly	rapidly	ADV
ajst-32482	18	16	,	,	PUNCT
ajst-32482	18	17	such	such	ADJ
ajst-32482	18	18	as	as	ADP
ajst-32482	18	19	those	those	PRON
ajst-32482	18	20	in	in	ADP
ajst-32482	18	21	hair	hair	NOUN
ajst-32482	18	22	follicles	follicle	NOUN
ajst-32482	18	23	and	and	CCONJ
ajst-32482	18	24	the	the	DET
ajst-32482	18	25	digestive	digestive	ADJ
ajst-32482	18	26	tract	tract	NOUN
ajst-32482	18	27	mucosa	mucosa	NOUN
ajst-32482	18	28	,	,	PUNCT
ajst-32482	18	29	resulting	result	VERB
ajst-32482	18	30	in	in	ADP
ajst-32482	18	31	severe	severe	ADJ
ajst-32482	18	32	side	side	NOUN
ajst-32482	18	33	effects	effect	NOUN
ajst-32482	18	34	,	,	PUNCT
ajst-32482	18	35	including	include	VERB
ajst-32482	18	36	hair	hair	NOUN
ajst-32482	18	37	loss	loss	NOUN
ajst-32482	18	38	,	,	PUNCT
ajst-32482	18	39	nausea	nausea	NOUN
ajst-32482	18	40	,	,	PUNCT
ajst-32482	18	41	vomiting	vomiting	NOUN
ajst-32482	18	42	,	,	PUNCT
ajst-32482	18	43	and	and	CCONJ
ajst-32482	18	44	decreased	decrease	VERB
ajst-32482	18	45	immunity	immunity	NOUN
ajst-32482	18	46	.	.	PUNCT
ajst-32482	19	1	radiotherapy	radiotherapy	NOUN
ajst-32482	19	2	destroys	destroy	VERB
ajst-32482	19	3	the	the	DET
ajst-32482	19	4	dna	dna	NOUN
ajst-32482	19	5	of	of	ADP
ajst-32482	19	6	cancer	cancer	NOUN
ajst-32482	19	7	cells	cell	NOUN
ajst-32482	19	8	through	through	ADP
ajst-32482	19	9	high	high	ADJ
ajst-32482	19	10	-	-	PUNCT
ajst-32482	19	11	energy	energy	NOUN
ajst-32482	19	12	rays	ray	NOUN
ajst-32482	19	13	to	to	PART
ajst-32482	19	14	inhibit	inhibit	VERB
ajst-32482	19	15	their	their	PRON
ajst-32482	19	16	proliferation	proliferation	NOUN
ajst-32482	19	17	.	.	PUNCT
ajst-32482	20	1	it	it	PRON
ajst-32482	20	2	can	can	AUX
ajst-32482	20	3	also	also	ADV
ajst-32482	20	4	damage	damage	VERB
ajst-32482	20	5	healthy	healthy	ADJ
ajst-32482	20	6	tissues	tissue	NOUN
ajst-32482	20	7	around	around	ADP
ajst-32482	20	8	the	the	DET
ajst-32482	20	9	tumor	tumor	NOUN
ajst-32482	20	10	,	,	PUNCT
ajst-32482	20	11	causing	cause	VERB
ajst-32482	20	12	problems	problem	NOUN
ajst-32482	20	13	such	such	ADJ
ajst-32482	20	14	as	as	ADP
ajst-32482	20	15	local	local	ADJ
ajst-32482	20	16	inflammation	inflammation	NOUN
ajst-32482	20	17	and	and	CCONJ
ajst-32482	20	18	fibrosis	fibrosis	NOUN
ajst-32482	20	19	.	.	PUNCT
ajst-32482	21	1	moreover	moreover	ADV
ajst-32482	21	2	,	,	PUNCT
ajst-32482	21	3	its	its	PRON
ajst-32482	21	4	therapeutic	therapeutic	ADJ
ajst-32482	21	5	effect	effect	NOUN
ajst-32482	21	6	is	be	AUX
ajst-32482	21	7	often	often	ADV
ajst-32482	21	8	limited	limit	VERB
ajst-32482	21	9	for	for	ADP
ajst-32482	21	10	cancers	cancer	NOUN
ajst-32482	21	11	metastasizing	metastasize	VERB
ajst-32482	21	12	to	to	ADP
ajst-32482	21	13	distant	distant	ADJ
ajst-32482	21	14	sites	site	NOUN
ajst-32482	21	15	.	.	PUNCT
ajst-32482	22	1	in	in	ADP
ajst-32482	22	2	addition	addition	NOUN
ajst-32482	22	3	,	,	PUNCT
ajst-32482	22	4	traditional	traditional	ADJ
ajst-32482	22	5	treatment	treatment	NOUN
ajst-32482	22	6	methods	method	NOUN
ajst-32482	22	7	are	be	AUX
ajst-32482	22	8	difficult	difficult	ADJ
ajst-32482	22	9	to	to	PART
ajst-32482	22	10	eliminate	eliminate	VERB
ajst-32482	22	11	all	all	DET
ajst-32482	22	12	cancer	cancer	NOUN
ajst-32482	22	13	cells	cell	NOUN
ajst-32482	22	14	,	,	PUNCT
ajst-32482	22	15	and	and	CCONJ
ajst-32482	22	16	many	many	ADJ
ajst-32482	22	17	patients	patient	NOUN
ajst-32482	22	18	will	will	AUX
ajst-32482	22	19	experience	experience	VERB
ajst-32482	22	20	recurrence	recurrence	NOUN
ajst-32482	22	21	or	or	CCONJ
ajst-32482	22	22	drug	drug	NOUN
ajst-32482	22	23	resistance	resistance	NOUN
ajst-32482	22	24	after	after	ADP
ajst-32482	22	25	treatment	treatment	NOUN
ajst-32482	22	26	,	,	PUNCT
ajst-32482	22	27	posing	pose	VERB
ajst-32482	22	28	significant	significant	ADJ
ajst-32482	22	29	challenges	challenge	NOUN
ajst-32482	22	30	to	to	ADP
ajst-32482	22	31	subsequent	subsequent	ADJ
ajst-32482	22	32	treatment	treatment	NOUN
ajst-32482	22	33	.	.	PUNCT
ajst-32482	23	1	cancer	cancer	NOUN
ajst-32482	23	2	immunotherapy	immunotherapy	NOUN
ajst-32482	23	3	has	have	AUX
ajst-32482	23	4	emerged	emerge	VERB
ajst-32482	23	5	as	as	ADP
ajst-32482	23	6	a	a	DET
ajst-32482	23	7	promising	promising	ADJ
ajst-32482	23	8	new	new	ADJ
ajst-32482	23	9	treatment	treatment	NOUN
ajst-32482	23	10	approach	approach	NOUN
ajst-32482	23	11	in	in	ADP
ajst-32482	23	12	recent	recent	ADJ
ajst-32482	23	13	years	year	NOUN
ajst-32482	23	14	.	.	PUNCT
ajst-32482	24	1	one	one	NUM
ajst-32482	24	2	of	of	ADP
ajst-32482	24	3	the	the	DET
ajst-32482	24	4	most	most	ADV
ajst-32482	24	5	notable	notable	ADJ
ajst-32482	24	6	advancements	advancement	NOUN
ajst-32482	24	7	in	in	ADP
ajst-32482	24	8	this	this	DET
ajst-32482	24	9	field	field	NOUN
ajst-32482	24	10	has	have	AUX
ajst-32482	24	11	been	be	AUX
ajst-32482	24	12	the	the	DET
ajst-32482	24	13	development	development	NOUN
ajst-32482	24	14	of	of	ADP
ajst-32482	24	15	immune	immune	ADJ
ajst-32482	24	16	checkpoint	checkpoint	NOUN
ajst-32482	24	17	inhibitors	inhibitor	NOUN
ajst-32482	24	18	,	,	PUNCT
ajst-32482	24	19	a	a	DET
ajst-32482	24	20	class	class	NOUN
ajst-32482	24	21	of	of	ADP
ajst-32482	24	22	drugs	drug	NOUN
ajst-32482	24	23	that	that	PRON
ajst-32482	24	24	has	have	AUX
ajst-32482	24	25	revolutionized	revolutionize	VERB
ajst-32482	24	26	cancer	cancer	NOUN
ajst-32482	24	27	treatment	treatment	NOUN
ajst-32482	24	28	.	.	PUNCT
ajst-32482	25	1	the	the	DET
ajst-32482	25	2	immune	immune	ADJ
ajst-32482	25	3	system	system	NOUN
ajst-32482	25	4	protects	protect	VERB
ajst-32482	25	5	the	the	DET
ajst-32482	25	6	body	body	NOUN
ajst-32482	25	7	against	against	ADP
ajst-32482	25	8	foreign	foreign	ADJ
ajst-32482	25	9	pathogens	pathogen	NOUN
ajst-32482	25	10	and	and	CCONJ
ajst-32482	25	11	abnormal	abnormal	ADJ
ajst-32482	25	12	cells	cell	NOUN
ajst-32482	25	13	,	,	PUNCT
ajst-32482	25	14	including	include	VERB
ajst-32482	25	15	those	those	PRON
ajst-32482	25	16	that	that	PRON
ajst-32482	25	17	cause	cause	VERB
ajst-32482	25	18	cancer	cancer	NOUN
ajst-32482	25	19	.	.	PUNCT
ajst-32482	26	1	t	t	NOUN
ajst-32482	26	2	cells	cell	NOUN
ajst-32482	26	3	,	,	PUNCT
ajst-32482	26	4	a	a	DET
ajst-32482	26	5	type	type	NOUN
ajst-32482	26	6	of	of	ADP
ajst-32482	26	7	immune	immune	ADJ
ajst-32482	26	8	cell	cell	NOUN
ajst-32482	26	9	,	,	PUNCT
ajst-32482	26	10	play	play	VERB
ajst-32482	26	11	a	a	DET
ajst-32482	26	12	critical	critical	ADJ
ajst-32482	26	13	role	role	NOUN
ajst-32482	26	14	in	in	ADP
ajst-32482	26	15	detecting	detect	VERB
ajst-32482	26	16	and	and	CCONJ
ajst-32482	26	17	attacking	attack	VERB
ajst-32482	26	18	tumor	tumor	NOUN
ajst-32482	26	19	cells	cell	NOUN
ajst-32482	26	20	.	.	PUNCT
ajst-32482	27	1	however	however	ADV
ajst-32482	27	2	,	,	PUNCT
ajst-32482	27	3	cancer	cancer	NOUN
ajst-32482	27	4	cells	cell	NOUN
ajst-32482	27	5	have	have	AUX
ajst-32482	27	6	developed	develop	VERB
ajst-32482	27	7	sophisticated	sophisticated	ADJ
ajst-32482	27	8	strategies	strategy	NOUN
ajst-32482	27	9	to	to	PART
ajst-32482	27	10	evade	evade	VERB
ajst-32482	27	11	immune	immune	ADJ
ajst-32482	27	12	surveillance	surveillance	NOUN
ajst-32482	28	1	[	[	X
ajst-32482	28	2	1	1	NUM
ajst-32482	28	3	]	]	PUNCT
ajst-32482	28	4	,	,	PUNCT
ajst-32482	28	5	one	one	NUM
ajst-32482	28	6	of	of	ADP
ajst-32482	28	7	which	which	PRON
ajst-32482	28	8	is	be	AUX
ajst-32482	28	9	the	the	DET
ajst-32482	28	10	activation	activation	NOUN
ajst-32482	28	11	of	of	ADP
ajst-32482	28	12	immune	immune	ADJ
ajst-32482	28	13	checkpoint	checkpoint	NOUN
ajst-32482	28	14	pathways	pathway	NOUN
ajst-32482	28	15	.	.	PUNCT
ajst-32482	29	1	these	these	DET
ajst-32482	29	2	pathways	pathway	NOUN
ajst-32482	29	3	act	act	VERB
ajst-32482	29	4	as	as	ADP
ajst-32482	29	5	“	"	PUNCT
ajst-32482	29	6	brakes	brake	NOUN
ajst-32482	29	7	”	"	PUNCT
ajst-32482	29	8	on	on	ADP
ajst-32482	29	9	the	the	DET
ajst-32482	29	10	immune	immune	ADJ
ajst-32482	29	11	system	system	NOUN
ajst-32482	29	12	,	,	PUNCT
ajst-32482	29	13	preventing	prevent	VERB
ajst-32482	29	14	it	it	PRON
ajst-32482	29	15	from	from	ADP
ajst-32482	29	16	attacking	attack	VERB
ajst-32482	29	17	cancer	cancer	NOUN
ajst-32482	29	18	cells	cell	NOUN
ajst-32482	29	19	.	.	PUNCT
ajst-32482	30	1	immune	immune	ADJ
ajst-32482	30	2	checkpoint	checkpoint	NOUN
ajst-32482	30	3	inhibitors	inhibitor	NOUN
ajst-32482	30	4	release	release	VERB
ajst-32482	30	5	these	these	DET
ajst-32482	30	6	brakes	brake	NOUN
ajst-32482	30	7	,	,	PUNCT
ajst-32482	30	8	allowing	allow	VERB
ajst-32482	30	9	the	the	DET
ajst-32482	30	10	immune	immune	ADJ
ajst-32482	30	11	system	system	NOUN
ajst-32482	30	12	to	to	PART
ajst-32482	30	13	recognize	recognize	VERB
ajst-32482	30	14	and	and	CCONJ
ajst-32482	30	15	destroy	destroy	VERB
ajst-32482	30	16	cancer	cancer	NOUN
ajst-32482	30	17	cells	cell	NOUN
ajst-32482	30	18	more	more	ADV
ajst-32482	30	19	effectively	effectively	ADV
ajst-32482	30	20	[	[	X
ajst-32482	30	21	2	2	NUM
ajst-32482	30	22	]	]	PUNCT
ajst-32482	30	23	.	.	PUNCT
ajst-32482	31	1	107	107	NUM
ajst-32482	31	2	the	the	DET
ajst-32482	31	3	immune	immune	ADJ
ajst-32482	31	4	system	system	NOUN
ajst-32482	31	5	has	have	AUX
ajst-32482	31	6	evolved	evolve	VERB
ajst-32482	31	7	primarily	primarily	ADV
ajst-32482	31	8	to	to	PART
ajst-32482	31	9	defend	defend	VERB
ajst-32482	31	10	the	the	DET
ajst-32482	31	11	host	host	NOUN
ajst-32482	31	12	from	from	ADP
ajst-32482	31	13	foreign	foreign	ADJ
ajst-32482	31	14	invaders	invader	NOUN
ajst-32482	31	15	,	,	PUNCT
ajst-32482	31	16	such	such	ADJ
ajst-32482	31	17	as	as	ADP
ajst-32482	31	18	harmful	harmful	ADJ
ajst-32482	31	19	microorganisms	microorganism	NOUN
ajst-32482	31	20	,	,	PUNCT
ajst-32482	31	21	viruses	virus	NOUN
ajst-32482	31	22	,	,	PUNCT
ajst-32482	31	23	and	and	CCONJ
ajst-32482	31	24	pathogens	pathogen	NOUN
ajst-32482	31	25	,	,	PUNCT
ajst-32482	31	26	all	all	PRON
ajst-32482	31	27	of	of	ADP
ajst-32482	31	28	which	which	PRON
ajst-32482	31	29	have	have	VERB
ajst-32482	31	30	the	the	DET
ajst-32482	31	31	potential	potential	NOUN
ajst-32482	31	32	to	to	PART
ajst-32482	31	33	cause	cause	VERB
ajst-32482	31	34	damage	damage	NOUN
ajst-32482	31	35	to	to	ADP
ajst-32482	31	36	the	the	DET
ajst-32482	31	37	body	body	NOUN
ajst-32482	31	38	.	.	PUNCT
ajst-32482	32	1	the	the	DET
ajst-32482	32	2	immune	immune	ADJ
ajst-32482	32	3	system	system	NOUN
ajst-32482	32	4	relies	rely	VERB
ajst-32482	32	5	on	on	ADP
ajst-32482	32	6	t	t	PROPN
ajst-32482	32	7	,	,	PUNCT
ajst-32482	32	8	b	b	NOUN
ajst-32482	32	9	,	,	PUNCT
ajst-32482	32	10	natural	natural	ADJ
ajst-32482	32	11	killer	killer	NOUN
ajst-32482	32	12	,	,	PUNCT
ajst-32482	32	13	and	and	CCONJ
ajst-32482	32	14	other	other	ADJ
ajst-32482	32	15	immune	immune	ADJ
ajst-32482	32	16	cells	cell	NOUN
ajst-32482	32	17	to	to	PART
ajst-32482	32	18	identify	identify	VERB
ajst-32482	32	19	and	and	CCONJ
ajst-32482	32	20	eliminate	eliminate	VERB
ajst-32482	32	21	these	these	DET
ajst-32482	32	22	threats	threat	NOUN
ajst-32482	32	23	[	[	X
ajst-32482	32	24	3	3	NUM
ajst-32482	32	25	]	]	PUNCT
ajst-32482	32	26	.	.	PUNCT
ajst-32482	33	1	at	at	ADP
ajst-32482	33	2	the	the	DET
ajst-32482	33	3	same	same	ADJ
ajst-32482	33	4	time	time	NOUN
ajst-32482	33	5	,	,	PUNCT
ajst-32482	33	6	the	the	DET
ajst-32482	33	7	immune	immune	ADJ
ajst-32482	33	8	system	system	NOUN
ajst-32482	33	9	must	must	AUX
ajst-32482	33	10	also	also	ADV
ajst-32482	33	11	maintain	maintain	VERB
ajst-32482	33	12	tolerance	tolerance	NOUN
ajst-32482	33	13	to	to	ADP
ajst-32482	33	14	the	the	DET
ajst-32482	33	15	body	body	NOUN
ajst-32482	33	16	's	's	PART
ajst-32482	33	17	cells	cell	NOUN
ajst-32482	33	18	and	and	CCONJ
ajst-32482	33	19	tissues	tissue	NOUN
ajst-32482	33	20	,	,	PUNCT
ajst-32482	33	21	preventing	prevent	VERB
ajst-32482	33	22	attacks	attack	NOUN
ajst-32482	33	23	on	on	ADP
ajst-32482	33	24	self	self	NOUN
ajst-32482	33	25	-	-	PUNCT
ajst-32482	33	26	antigens	antigen	NOUN
ajst-32482	33	27	.	.	PUNCT
ajst-32482	34	1	this	this	DET
ajst-32482	34	2	balance	balance	NOUN
ajst-32482	34	3	is	be	AUX
ajst-32482	34	4	achieved	achieve	VERB
ajst-32482	34	5	through	through	ADP
ajst-32482	34	6	mechanisms	mechanism	NOUN
ajst-32482	34	7	such	such	ADJ
ajst-32482	34	8	as	as	ADP
ajst-32482	34	9	deleting	delete	VERB
ajst-32482	34	10	auto	auto	NOUN
ajst-32482	34	11	-	-	PUNCT
ajst-32482	34	12	reactive	reactive	NOUN
ajst-32482	34	13	t	t	NOUN
ajst-32482	34	14	and	and	CCONJ
ajst-32482	34	15	b	b	PROPN
ajst-32482	34	16	cells	cell	NOUN
ajst-32482	34	17	during	during	ADP
ajst-32482	34	18	their	their	PRON
ajst-32482	34	19	development	development	NOUN
ajst-32482	34	20	in	in	ADP
ajst-32482	34	21	the	the	DET
ajst-32482	34	22	thymus	thymus	NOUN
ajst-32482	34	23	and	and	CCONJ
ajst-32482	34	24	bone	bone	NOUN
ajst-32482	34	25	marrow	marrow	NOUN
ajst-32482	34	26	,	,	PUNCT
ajst-32482	34	27	a	a	DET
ajst-32482	34	28	process	process	NOUN
ajst-32482	34	29	known	know	VERB
ajst-32482	34	30	as	as	ADP
ajst-32482	34	31	central	central	ADJ
ajst-32482	34	32	tolerance	tolerance	NOUN
ajst-32482	34	33	.	.	PUNCT
ajst-32482	35	1	2	2	X
ajst-32482	35	2	.	.	X
ajst-32482	35	3	biological	biological	ADJ
ajst-32482	35	4	mechanism	mechanism	NOUN
ajst-32482	35	5	of	of	ADP
ajst-32482	35	6	the	the	DET
ajst-32482	35	7	immune	immune	ADJ
ajst-32482	35	8	checkpoints	checkpoint	NOUN
ajst-32482	35	9	2.1	2.1	NUM
ajst-32482	35	10	function	function	NOUN
ajst-32482	35	11	of	of	ADP
ajst-32482	35	12	the	the	DET
ajst-32482	35	13	immune	immune	ADJ
ajst-32482	35	14	checkpoints	checkpoint	NOUN
ajst-32482	35	15	immune	immune	ADJ
ajst-32482	35	16	checkpoints	checkpoint	NOUN
ajst-32482	35	17	are	be	AUX
ajst-32482	35	18	crucial	crucial	ADJ
ajst-32482	35	19	regulators	regulator	NOUN
ajst-32482	35	20	in	in	ADP
ajst-32482	35	21	the	the	DET
ajst-32482	35	22	immune	immune	ADJ
ajst-32482	35	23	system	system	NOUN
ajst-32482	35	24	,	,	PUNCT
ajst-32482	35	25	and	and	CCONJ
ajst-32482	35	26	pd-1	pd-1	ADP
ajst-32482	35	27	/	/	SYM
ajst-32482	35	28	pd	pd	NOUN
ajst-32482	35	29	-	-	PROPN
ajst-32482	35	30	l1	l1	PROPN
ajst-32482	35	31	and	and	CCONJ
ajst-32482	35	32	ctla-4	ctla-4	NOUN
ajst-32482	35	33	represent	represent	VERB
ajst-32482	35	34	two	two	NUM
ajst-32482	35	35	classic	classic	ADJ
ajst-32482	35	36	inhibitory	inhibitory	ADJ
ajst-32482	35	37	pathways	pathway	NOUN
ajst-32482	35	38	that	that	PRON
ajst-32482	35	39	act	act	VERB
ajst-32482	35	40	as	as	ADP
ajst-32482	35	41	“	"	PUNCT
ajst-32482	35	42	brakes	brake	NOUN
ajst-32482	35	43	”	"	PUNCT
ajst-32482	35	44	to	to	ADP
ajst-32482	35	45	fine	fine	ADJ
ajst-32482	35	46	-	-	PUNCT
ajst-32482	35	47	tune	tune	NOUN
ajst-32482	35	48	immune	immune	ADJ
ajst-32482	35	49	activation	activation	NOUN
ajst-32482	35	50	.	.	PUNCT
ajst-32482	36	1	for	for	ADP
ajst-32482	36	2	the	the	DET
ajst-32482	36	3	pd-1	pd-1	ADJ
ajst-32482	36	4	/	/	SYM
ajst-32482	36	5	pd	pd	ADJ
ajst-32482	36	6	-	-	PROPN
ajst-32482	36	7	l1	l1	PROPN
ajst-32482	36	8	pathway	pathway	NOUN
ajst-32482	36	9	,	,	PUNCT
ajst-32482	36	10	pd-1is	pd-1i	VERB
ajst-32482	36	11	a	a	DET
ajst-32482	36	12	receptor	receptor	NOUN
ajst-32482	36	13	mainly	mainly	ADV
ajst-32482	36	14	expressed	express	VERB
ajst-32482	36	15	on	on	ADP
ajst-32482	36	16	activated	activate	VERB
ajst-32482	36	17	t	t	NOUN
ajst-32482	36	18	cells	cell	NOUN
ajst-32482	36	19	.	.	PUNCT
ajst-32482	37	1	pd	pd	PROPN
ajst-32482	37	2	-	-	PROPN
ajst-32482	37	3	l1	l1	PROPN
ajst-32482	37	4	(	(	PUNCT
ajst-32482	37	5	programmed	program	VERB
ajst-32482	37	6	death	death	NOUN
ajst-32482	37	7	-	-	PUNCT
ajst-32482	37	8	ligand	ligand	NOUN
ajst-32482	37	9	1	1	NUM
ajst-32482	37	10	)	)	PUNCT
ajst-32482	37	11	and	and	CCONJ
ajst-32482	37	12	its	its	PRON
ajst-32482	37	13	ligand	ligand	NOUN
ajst-32482	37	14	can	can	AUX
ajst-32482	37	15	be	be	AUX
ajst-32482	37	16	highly	highly	ADV
ajst-32482	37	17	expressed	express	VERB
ajst-32482	37	18	on	on	ADP
ajst-32482	37	19	various	various	ADJ
ajst-32482	37	20	cells	cell	NOUN
ajst-32482	37	21	,	,	PUNCT
ajst-32482	37	22	including	include	VERB
ajst-32482	37	23	cancer	cancer	NOUN
ajst-32482	37	24	cells	cell	NOUN
ajst-32482	37	25	and	and	CCONJ
ajst-32482	37	26	cells	cell	NOUN
ajst-32482	37	27	within	within	ADP
ajst-32482	37	28	the	the	DET
ajst-32482	37	29	tumor	tumor	NOUN
ajst-32482	37	30	microenvironment	microenvironment	NOUN
ajst-32482	37	31	.	.	PUNCT
ajst-32482	38	1	when	when	SCONJ
ajst-32482	38	2	pd	pd	PROPN
ajst-32482	38	3	-	-	PROPN
ajst-32482	38	4	l1	l1	PROPN
ajst-32482	38	5	on	on	ADP
ajst-32482	38	6	target	target	NOUN
ajst-32482	38	7	cells	cell	NOUN
ajst-32482	38	8	binds	bind	VERB
ajst-32482	38	9	to	to	PART
ajst-32482	38	10	pd1	pd1	VERB
ajst-32482	38	11	on	on	ADP
ajst-32482	38	12	t	t	NOUN
ajst-32482	38	13	cells	cell	NOUN
ajst-32482	38	14	,	,	PUNCT
ajst-32482	38	15	it	it	PRON
ajst-32482	38	16	triggers	trigger	VERB
ajst-32482	38	17	intracellular	intracellular	ADJ
ajst-32482	38	18	signaling	signal	VERB
ajst-32482	38	19	events	event	NOUN
ajst-32482	38	20	.	.	PUNCT
ajst-32482	39	1	as	as	SCONJ
ajst-32482	39	2	described	describe	VERB
ajst-32482	39	3	in	in	ADP
ajst-32482	39	4	the	the	DET
ajst-32482	39	5	literature	literature	NOUN
ajst-32482	39	6	[	[	X
ajst-32482	39	7	4	4	NUM
ajst-32482	39	8	]	]	PUNCT
ajst-32482	39	9	,	,	PUNCT
ajst-32482	39	10	this	this	DET
ajst-32482	39	11	binding	bind	VERB
ajst-32482	39	12	recruits	recruit	VERB
ajst-32482	39	13	the	the	DET
ajst-32482	39	14	src	src	NOUN
ajst-32482	39	15	homology	homology	NOUN
ajst-32482	39	16	region	region	NOUN
ajst-32482	39	17	2	2	NUM
ajst-32482	39	18	domain	domain	NOUN
ajst-32482	39	19	-	-	PUNCT
ajst-32482	39	20	containing	contain	VERB
ajst-32482	39	21	phosphatase-2	phosphatase-2	PROPN
ajst-32482	39	22	(	(	PUNCT
ajst-32482	39	23	shp2	shp2	NOUN
ajst-32482	39	24	)	)	PUNCT
ajst-32482	39	25	.	.	PUNCT
ajst-32482	40	1	shp2	shp2	NOUN
ajst-32482	40	2	then	then	ADV
ajst-32482	40	3	dephosphorylates	dephosphorylate	VERB
ajst-32482	40	4	key	key	ADJ
ajst-32482	40	5	signaling	signal	VERB
ajst-32482	40	6	molecules	molecule	NOUN
ajst-32482	40	7	associated	associate	VERB
ajst-32482	40	8	with	with	ADP
ajst-32482	40	9	the	the	DET
ajst-32482	40	10	t	t	NOUN
ajst-32482	40	11	-	-	PUNCT
ajst-32482	40	12	cell	cell	NOUN
ajst-32482	40	13	receptor	receptor	NOUN
ajst-32482	40	14	(	(	PUNCT
ajst-32482	40	15	tcr	tcr	PROPN
ajst-32482	40	16	)	)	PUNCT
ajst-32482	40	17	,	,	PUNCT
ajst-32482	40	18	such	such	ADJ
ajst-32482	40	19	as	as	ADP
ajst-32482	40	20	cd3	cd3	NOUN
ajst-32482	40	21	and	and	CCONJ
ajst-32482	40	22	zap70	zap70	PROPN
ajst-32482	40	23	signalosomes	signalosome	NOUN
ajst-32482	40	24	.	.	PUNCT
ajst-32482	41	1	this	this	DET
ajst-32482	41	2	process	process	NOUN
ajst-32482	41	3	attenuates	attenuate	VERB
ajst-32482	41	4	downstream	downstream	ADJ
ajst-32482	41	5	tcr	tcr	PROPN
ajst-32482	41	6	signaling	signal	VERB
ajst-32482	41	7	,	,	PUNCT
ajst-32482	41	8	ultimately	ultimately	ADV
ajst-32482	41	9	suppressing	suppress	VERB
ajst-32482	41	10	t	t	NOUN
ajst-32482	41	11	-	-	PUNCT
ajst-32482	41	12	cell	cell	NOUN
ajst-32482	41	13	activation	activation	NOUN
ajst-32482	41	14	,	,	PUNCT
ajst-32482	41	15	proliferation	proliferation	NOUN
ajst-32482	41	16	,	,	PUNCT
ajst-32482	41	17	and	and	CCONJ
ajst-32482	41	18	cytokine	cytokine	ADJ
ajst-32482	41	19	secretion	secretion	NOUN
ajst-32482	41	20	,	,	PUNCT
ajst-32482	41	21	effectively	effectively	ADV
ajst-32482	41	22	putting	put	VERB
ajst-32482	41	23	a	a	DET
ajst-32482	41	24	“	"	PUNCT
ajst-32482	41	25	brake	brake	NOUN
ajst-32482	41	26	”	"	PUNCT
ajst-32482	41	27	on	on	ADP
ajst-32482	41	28	the	the	DET
ajst-32482	41	29	t	t	NOUN
ajst-32482	41	30	-	-	PUNCT
ajst-32482	41	31	cellmediated	cellmediate	VERB
ajst-32482	41	32	immune	immune	ADJ
ajst-32482	41	33	response	response	NOUN
ajst-32482	41	34	[	[	X
ajst-32482	41	35	4	4	NUM
ajst-32482	41	36	]	]	PUNCT
ajst-32482	41	37	.	.	PUNCT
ajst-32482	42	1	regarding	regard	VERB
ajst-32482	42	2	the	the	DET
ajst-32482	42	3	ctla-4	ctla-4	NOUN
ajst-32482	42	4	pathway	pathway	NOUN
ajst-32482	42	5	,	,	PUNCT
ajst-32482	42	6	ctla-4	ctla-4	PRON
ajst-32482	42	7	is	be	AUX
ajst-32482	42	8	expressed	express	VERB
ajst-32482	42	9	on	on	ADP
ajst-32482	42	10	activated	activate	VERB
ajst-32482	42	11	cd4	cd4	PROPN
ajst-32482	42	12	+	+	PROPN
ajst-32482	42	13	and	and	CCONJ
ajst-32482	42	14	cd8	cd8	PROPN
ajst-32482	42	15	+	+	PROPN
ajst-32482	42	16	t	t	NOUN
ajst-32482	42	17	cells	cell	NOUN
ajst-32482	42	18	.	.	PUNCT
ajst-32482	43	1	it	it	PRON
ajst-32482	43	2	shares	share	VERB
ajst-32482	43	3	structural	structural	ADJ
ajst-32482	43	4	homology	homology	NOUN
ajst-32482	43	5	with	with	ADP
ajst-32482	43	6	cd28	cd28	PROPN
ajst-32482	43	7	,	,	PUNCT
ajst-32482	43	8	a	a	DET
ajst-32482	43	9	co	co	ADJ
ajst-32482	43	10	-	-	ADJ
ajst-32482	43	11	stimulatory	stimulatory	ADJ
ajst-32482	43	12	receptor	receptor	NOUN
ajst-32482	43	13	on	on	ADP
ajst-32482	43	14	t	t	NOUN
ajst-32482	43	15	cells	cell	NOUN
ajst-32482	43	16	,	,	PUNCT
ajst-32482	43	17	and	and	CCONJ
ajst-32482	43	18	competes	compete	VERB
ajst-32482	43	19	with	with	ADP
ajst-32482	43	20	cd28	cd28	PROPN
ajst-32482	43	21	for	for	ADP
ajst-32482	43	22	binding	bind	VERB
ajst-32482	43	23	to	to	ADP
ajst-32482	43	24	the	the	DET
ajst-32482	43	25	same	same	ADJ
ajst-32482	43	26	ligand	ligand	NOUN
ajst-32482	43	27	,	,	PUNCT
ajst-32482	43	28	cd80	cd80	PROPN
ajst-32482	43	29	(	(	PUNCT
ajst-32482	43	30	b7	b7	PROPN
ajst-32482	43	31	-	-	PUNCT
ajst-32482	43	32	1	1	NUM
ajst-32482	43	33	)	)	PUNCT
ajst-32482	43	34	and	and	CCONJ
ajst-32482	43	35	cd86	cd86	PROPN
ajst-32482	43	36	(	(	PUNCT
ajst-32482	43	37	b7	b7	PROPN
ajst-32482	43	38	-	-	PUNCT
ajst-32482	43	39	2	2	NUM
ajst-32482	43	40	)	)	PUNCT
ajst-32482	43	41	,	,	PUNCT
ajst-32482	43	42	which	which	PRON
ajst-32482	43	43	are	be	AUX
ajst-32482	43	44	present	present	ADJ
ajst-32482	43	45	on	on	ADP
ajst-32482	43	46	antigenpresenting	antigenpresente	VERB
ajst-32482	43	47	cells	cell	NOUN
ajst-32482	43	48	(	(	PUNCT
ajst-32482	43	49	apcs	apc	NOUN
ajst-32482	43	50	)	)	PUNCT
ajst-32482	43	51	.	.	PUNCT
ajst-32482	44	1	as	as	SCONJ
ajst-32482	44	2	indicated	indicate	VERB
ajst-32482	44	3	in	in	ADP
ajst-32482	44	4	relevant	relevant	ADJ
ajst-32482	44	5	literature	literature	NOUN
ajst-32482	44	6	[	[	X
ajst-32482	44	7	5	5	NUM
ajst-32482	44	8	]	]	PUNCT
ajst-32482	44	9	,	,	PUNCT
ajst-32482	44	10	by	by	ADP
ajst-32482	44	11	outcompeting	outcompete	VERB
ajst-32482	44	12	cd28	cd28	PROPN
ajst-32482	44	13	for	for	ADP
ajst-32482	44	14	these	these	DET
ajst-32482	44	15	ligands	ligand	NOUN
ajst-32482	44	16	,	,	PUNCT
ajst-32482	44	17	ctla-4	ctla-4	PRON
ajst-32482	44	18	delivers	deliver	VERB
ajst-32482	44	19	inhibitory	inhibitory	ADJ
ajst-32482	44	20	signals	signal	NOUN
ajst-32482	44	21	to	to	ADP
ajst-32482	44	22	t	t	NOUN
ajst-32482	44	23	cells	cell	NOUN
ajst-32482	44	24	.	.	PUNCT
ajst-32482	45	1	this	this	PRON
ajst-32482	45	2	blocks	block	VERB
ajst-32482	45	3	the	the	DET
ajst-32482	45	4	co	co	ADJ
ajst-32482	45	5	-	-	ADJ
ajst-32482	45	6	stimulatory	stimulatory	ADJ
ajst-32482	45	7	signals	signal	NOUN
ajst-32482	45	8	necessary	necessary	ADJ
ajst-32482	45	9	for	for	ADP
ajst-32482	45	10	full	full	ADJ
ajst-32482	45	11	t	t	PROPN
ajst-32482	45	12	-	-	PUNCT
ajst-32482	45	13	cell	cell	NOUN
ajst-32482	45	14	activation	activation	NOUN
ajst-32482	45	15	,	,	PUNCT
ajst-32482	45	16	thereby	thereby	ADV
ajst-32482	45	17	reducing	reduce	VERB
ajst-32482	45	18	t	t	NOUN
ajst-32482	45	19	-	-	PUNCT
ajst-32482	45	20	cell	cell	NOUN
ajst-32482	45	21	proliferation	proliferation	NOUN
ajst-32482	45	22	and	and	CCONJ
ajst-32482	45	23	the	the	DET
ajst-32482	45	24	production	production	NOUN
ajst-32482	45	25	of	of	ADP
ajst-32482	45	26	proinflammatory	proinflammatory	ADJ
ajst-32482	45	27	cytokines	cytokine	NOUN
ajst-32482	45	28	,	,	PUNCT
ajst-32482	45	29	serving	serve	VERB
ajst-32482	45	30	as	as	ADP
ajst-32482	45	31	another	another	DET
ajst-32482	45	32	critical	critical	ADJ
ajst-32482	45	33	“	"	PUNCT
ajst-32482	45	34	brake	brake	NOUN
ajst-32482	45	35	”	"	PUNCT
ajst-32482	45	36	to	to	PART
ajst-32482	45	37	prevent	prevent	VERB
ajst-32482	45	38	excessive	excessive	ADJ
ajst-32482	45	39	immune	immune	ADJ
ajst-32482	45	40	activation	activation	NOUN
ajst-32482	45	41	[	[	X
ajst-32482	45	42	4,5	4,5	NUM
ajst-32482	45	43	]	]	PUNCT
ajst-32482	45	44	.	.	PUNCT
ajst-32482	46	1	2.2	2.2	NUM
ajst-32482	46	2	t	t	NOUN
ajst-32482	46	3	cells	cell	NOUN
ajst-32482	46	4	and	and	CCONJ
ajst-32482	46	5	the	the	DET
ajst-32482	46	6	blocked	block	VERB
ajst-32482	46	7	links	link	NOUN
ajst-32482	46	8	in	in	ADP
ajst-32482	46	9	the	the	DET
ajst-32482	46	10	activation	activation	NOUN
ajst-32482	46	11	process	process	NOUN
ajst-32482	46	12	t	t	NOUN
ajst-32482	46	13	cells	cell	NOUN
ajst-32482	46	14	play	play	VERB
ajst-32482	46	15	a	a	DET
ajst-32482	46	16	central	central	ADJ
ajst-32482	46	17	role	role	NOUN
ajst-32482	46	18	in	in	ADP
ajst-32482	46	19	adaptive	adaptive	ADJ
ajst-32482	46	20	immunity	immunity	NOUN
ajst-32482	46	21	,	,	PUNCT
ajst-32482	46	22	and	and	CCONJ
ajst-32482	46	23	their	their	PRON
ajst-32482	46	24	activation	activation	NOUN
ajst-32482	46	25	relies	rely	VERB
ajst-32482	46	26	on	on	ADP
ajst-32482	46	27	a	a	DET
ajst-32482	46	28	“	"	PUNCT
ajst-32482	46	29	dual	dual	ADJ
ajst-32482	46	30	-	-	PUNCT
ajst-32482	46	31	signal	signal	NOUN
ajst-32482	46	32	”	"	PUNCT
ajst-32482	46	33	system	system	NOUN
ajst-32482	46	34	,	,	PUNCT
ajst-32482	46	35	which	which	PRON
ajst-32482	46	36	can	can	AUX
ajst-32482	46	37	be	be	AUX
ajst-32482	46	38	interrupted	interrupt	VERB
ajst-32482	46	39	by	by	ADP
ajst-32482	46	40	immune	immune	ADJ
ajst-32482	46	41	checkpoints	checkpoint	NOUN
ajst-32482	46	42	at	at	ADP
ajst-32482	46	43	specific	specific	ADJ
ajst-32482	46	44	steps	step	NOUN
ajst-32482	46	45	.	.	PUNCT
ajst-32482	47	1	first	first	ADV
ajst-32482	47	2	,	,	PUNCT
ajst-32482	47	3	for	for	ADP
ajst-32482	47	4	t	t	NOUN
ajst-32482	47	5	-	-	PUNCT
ajst-32482	47	6	cell	cell	NOUN
ajst-32482	47	7	activation	activation	NOUN
ajst-32482	47	8	to	to	PART
ajst-32482	47	9	occur	occur	VERB
ajst-32482	47	10	,	,	PUNCT
ajst-32482	47	11	antigen	antigen	NOUN
ajst-32482	47	12	-	-	PUNCT
ajst-32482	47	13	presenting	present	VERB
ajst-32482	47	14	cells	cell	NOUN
ajst-32482	47	15	can	can	AUX
ajst-32482	47	16	capture	capture	VERB
ajst-32482	47	17	and	and	CCONJ
ajst-32482	47	18	process	process	VERB
ajst-32482	47	19	the	the	DET
ajst-32482	47	20	antigens	antigen	NOUN
ajst-32482	47	21	,	,	PUNCT
ajst-32482	47	22	then	then	ADV
ajst-32482	47	23	present	present	VERB
ajst-32482	47	24	them	they	PRON
ajst-32482	47	25	to	to	ADP
ajst-32482	47	26	the	the	DET
ajst-32482	47	27	tcell	tcell	NOUN
ajst-32482	47	28	receptor	receptor	NOUN
ajst-32482	47	29	via	via	ADP
ajst-32482	47	30	major	major	ADJ
ajst-32482	47	31	histocompatibility	histocompatibility	NOUN
ajst-32482	47	32	complex	complex	ADJ
ajst-32482	47	33	molecules	molecule	NOUN
ajst-32482	47	34	.	.	PUNCT
ajst-32482	48	1	this	this	PRON
ajst-32482	48	2	is	be	AUX
ajst-32482	48	3	the	the	DET
ajst-32482	48	4	first	first	ADJ
ajst-32482	48	5	signal	signal	NOUN
ajst-32482	48	6	.	.	PUNCT
ajst-32482	49	1	the	the	DET
ajst-32482	49	2	second	second	ADJ
ajst-32482	49	3	signal	signal	NOUN
ajst-32482	49	4	comes	come	VERB
ajst-32482	49	5	from	from	ADP
ajst-32482	49	6	co	co	ADJ
ajst-32482	49	7	-	-	ADJ
ajst-32482	49	8	stimulatory	stimulatory	ADJ
ajst-32482	49	9	molecules	molecule	NOUN
ajst-32482	49	10	,	,	PUNCT
ajst-32482	49	11	the	the	DET
ajst-32482	49	12	cd80	cd80	PROPN
ajst-32482	49	13	/	/	SYM
ajst-32482	49	14	cd86	cd86	PROPN
ajst-32482	49	15	on	on	ADP
ajst-32482	49	16	apcs	apc	NOUN
ajst-32482	49	17	bind	bind	VERB
ajst-32482	49	18	to	to	ADP
ajst-32482	49	19	cd28	cd28	PROPN
ajst-32482	49	20	on	on	ADP
ajst-32482	49	21	t	t	NOUN
ajst-32482	49	22	cells	cell	NOUN
ajst-32482	49	23	,	,	PUNCT
ajst-32482	49	24	providing	provide	VERB
ajst-32482	49	25	essential	essential	ADJ
ajst-32482	49	26	co	co	ADJ
ajst-32482	49	27	-	-	ADJ
ajst-32482	49	28	stimulatory	stimulatory	ADJ
ajst-32482	49	29	signals	signal	NOUN
ajst-32482	49	30	that	that	PRON
ajst-32482	49	31	fully	fully	ADV
ajst-32482	49	32	activate	activate	VERB
ajst-32482	49	33	t	t	NOUN
ajst-32482	49	34	cells	cell	NOUN
ajst-32482	49	35	to	to	PART
ajst-32482	49	36	target	target	VERB
ajst-32482	49	37	and	and	CCONJ
ajst-32482	49	38	eliminate	eliminate	VERB
ajst-32482	49	39	pathogeninfected	pathogeninfecte	VERB
ajst-32482	49	40	or	or	CCONJ
ajst-32482	49	41	abnormal	abnormal	ADJ
ajst-32482	49	42	cells	cell	NOUN
ajst-32482	49	43	.	.	PUNCT
ajst-32482	50	1	immune	immune	ADJ
ajst-32482	50	2	checkpoints	checkpoint	NOUN
ajst-32482	50	3	interfere	interfere	VERB
ajst-32482	50	4	with	with	ADP
ajst-32482	50	5	this	this	DET
ajst-32482	50	6	activation	activation	NOUN
ajst-32482	50	7	process	process	NOUN
ajst-32482	50	8	.	.	PUNCT
ajst-32482	51	1	in	in	ADP
ajst-32482	51	2	the	the	DET
ajst-32482	51	3	case	case	NOUN
ajst-32482	51	4	of	of	ADP
ajst-32482	51	5	the	the	DET
ajst-32482	51	6	pd-1	pd-1	NOUN
ajst-32482	51	7	/	/	SYM
ajst-32482	51	8	pd	pd	ADJ
ajst-32482	51	9	-	-	PROPN
ajst-32482	51	10	l1	l1	PROPN
ajst-32482	51	11	pathway	pathway	NOUN
ajst-32482	51	12	,	,	PUNCT
ajst-32482	51	13	as	as	SCONJ
ajst-32482	51	14	t	t	PROPN
ajst-32482	51	15	cells	cell	NOUN
ajst-32482	51	16	express	express	VERB
ajst-32482	51	17	pd-1	pd-1	ADP
ajst-32482	51	18	,	,	PUNCT
ajst-32482	51	19	the	the	DET
ajst-32482	51	20	binding	binding	NOUN
ajst-32482	51	21	of	of	ADP
ajst-32482	51	22	pd-1	pd-1	ADP
ajst-32482	51	23	to	to	ADP
ajst-32482	51	24	pd	pd	PROPN
ajst-32482	51	25	-	-	PUNCT
ajst-32482	51	26	l1	l1	PROPN
ajst-32482	51	27	,	,	PUNCT
ajst-32482	51	28	which	which	PRON
ajst-32482	51	29	is	be	AUX
ajst-32482	51	30	expressed	express	VERB
ajst-32482	51	31	on	on	ADP
ajst-32482	51	32	apcs	apc	NOUN
ajst-32482	51	33	or	or	CCONJ
ajst-32482	51	34	other	other	ADJ
ajst-32482	51	35	cells	cell	NOUN
ajst-32482	51	36	,	,	PUNCT
ajst-32482	51	37	can	can	AUX
ajst-32482	51	38	disrupt	disrupt	VERB
ajst-32482	51	39	the	the	DET
ajst-32482	51	40	downstream	downstream	ADJ
ajst-32482	51	41	signaling	signaling	NOUN
ajst-32482	51	42	of	of	ADP
ajst-32482	51	43	the	the	DET
ajst-32482	51	44	tcr	tcr	PROPN
ajst-32482	51	45	-	-	PUNCT
ajst-32482	51	46	cd3	cd3	PROPN
ajst-32482	51	47	complex	complex	NOUN
ajst-32482	51	48	.	.	PUNCT
ajst-32482	52	1	as	as	SCONJ
ajst-32482	52	2	i	i	PRON
ajst-32482	52	3	mentioned	mention	VERB
ajst-32482	52	4	earlier	early	ADV
ajst-32482	52	5	,	,	PUNCT
ajst-32482	52	6	shp2mediated	shp2mediate	VERB
ajst-32482	52	7	signaling	signal	VERB
ajst-32482	52	8	molecules	molecule	NOUN
ajst-32482	52	9	(	(	PUNCT
ajst-32482	52	10	cd3	cd3	PROPN
ajst-32482	52	11	,	,	PUNCT
ajst-32482	52	12	zap70	zap70	PROPN
ajst-32482	52	13	)	)	PUNCT
ajst-32482	52	14	attenuate	attenuate	VERB
ajst-32482	52	15	the	the	DET
ajst-32482	52	16	intensity	intensity	NOUN
ajst-32482	52	17	of	of	ADP
ajst-32482	52	18	tcr	tcr	PROPN
ajst-32482	52	19	signaling	signal	VERB
ajst-32482	52	20	,	,	PUNCT
ajst-32482	52	21	making	make	VERB
ajst-32482	52	22	it	it	PRON
ajst-32482	52	23	challenging	challenge	VERB
ajst-32482	52	24	for	for	ADP
ajst-32482	52	25	t	t	PROPN
ajst-32482	52	26	cells	cell	NOUN
ajst-32482	52	27	to	to	PART
ajst-32482	52	28	receive	receive	VERB
ajst-32482	52	29	sufficient	sufficient	ADJ
ajst-32482	52	30	activation	activation	NOUN
ajst-32482	52	31	signals	signal	NOUN
ajst-32482	52	32	,	,	PUNCT
ajst-32482	52	33	even	even	ADV
ajst-32482	52	34	when	when	SCONJ
ajst-32482	52	35	the	the	DET
ajst-32482	52	36	initial	initial	ADJ
ajst-32482	52	37	signal	signal	NOUN
ajst-32482	52	38	(	(	PUNCT
ajst-32482	52	39	tcrmhc	tcrmhc	NOUN
ajst-32482	52	40	interaction	interaction	NOUN
ajst-32482	52	41	)	)	PUNCT
ajst-32482	52	42	is	be	AUX
ajst-32482	52	43	present	present	ADJ
ajst-32482	53	1	[	[	X
ajst-32482	53	2	4	4	NUM
ajst-32482	53	3	]	]	PUNCT
ajst-32482	53	4	.	.	PUNCT
ajst-32482	54	1	for	for	ADP
ajst-32482	54	2	the	the	DET
ajst-32482	54	3	ctla-4	ctla-4	NOUN
ajst-32482	54	4	pathway	pathway	NOUN
ajst-32482	54	5	,	,	PUNCT
ajst-32482	54	6	since	since	SCONJ
ajst-32482	54	7	ctla-4	ctla-4	PRON
ajst-32482	54	8	competes	compete	VERB
ajst-32482	54	9	with	with	ADP
ajst-32482	54	10	cd28	cd28	PROPN
ajst-32482	54	11	for	for	ADP
ajst-32482	54	12	binding	bind	VERB
ajst-32482	54	13	to	to	ADP
ajst-32482	54	14	cd80	cd80	PROPN
ajst-32482	54	15	/	/	SYM
ajst-32482	54	16	cd86	cd86	PROPN
ajst-32482	54	17	,	,	PUNCT
ajst-32482	54	18	it	it	PRON
ajst-32482	54	19	directly	directly	ADV
ajst-32482	54	20	blocks	block	VERB
ajst-32482	54	21	the	the	DET
ajst-32482	54	22	second	second	ADJ
ajst-32482	54	23	signal	signal	NOUN
ajst-32482	54	24	(	(	PUNCT
ajst-32482	54	25	co	co	ADJ
ajst-32482	54	26	-	-	ADJ
ajst-32482	54	27	stimulatory	stimulatory	ADJ
ajst-32482	54	28	signal	signal	NOUN
ajst-32482	54	29	)	)	PUNCT
ajst-32482	54	30	required	require	VERB
ajst-32482	54	31	for	for	ADP
ajst-32482	54	32	t	t	NOUN
ajst-32482	54	33	-	-	PUNCT
ajst-32482	54	34	cell	cell	NOUN
ajst-32482	54	35	activation	activation	NOUN
ajst-32482	54	36	.	.	PUNCT
ajst-32482	55	1	without	without	ADP
ajst-32482	55	2	adequate	adequate	ADJ
ajst-32482	55	3	co	co	NOUN
ajst-32482	55	4	-	-	NOUN
ajst-32482	55	5	stimulation	stimulation	ADJ
ajst-32482	55	6	,	,	PUNCT
ajst-32482	55	7	t	t	NOUN
ajst-32482	55	8	cells	cell	NOUN
ajst-32482	55	9	can	can	AUX
ajst-32482	55	10	not	not	PART
ajst-32482	55	11	be	be	AUX
ajst-32482	55	12	fully	fully	ADV
ajst-32482	55	13	activated	activate	VERB
ajst-32482	55	14	,	,	PUNCT
ajst-32482	55	15	and	and	CCONJ
ajst-32482	55	16	their	their	PRON
ajst-32482	55	17	proliferation	proliferation	NOUN
ajst-32482	55	18	and	and	CCONJ
ajst-32482	55	19	effector	effector	NOUN
ajst-32482	55	20	functions	function	NOUN
ajst-32482	55	21	(	(	PUNCT
ajst-32482	55	22	such	such	ADJ
ajst-32482	55	23	as	as	ADP
ajst-32482	55	24	cytokine	cytokine	ADJ
ajst-32482	55	25	production	production	NOUN
ajst-32482	55	26	and	and	CCONJ
ajst-32482	55	27	cytotoxic	cytotoxic	ADJ
ajst-32482	55	28	activity	activity	NOUN
ajst-32482	55	29	)	)	PUNCT
ajst-32482	55	30	are	be	AUX
ajst-32482	55	31	significantly	significantly	ADV
ajst-32482	55	32	inhibited	inhibit	VERB
ajst-32482	55	33	,	,	PUNCT
ajst-32482	55	34	even	even	ADV
ajst-32482	55	35	if	if	SCONJ
ajst-32482	55	36	the	the	DET
ajst-32482	55	37	tcr	tcr	PROPN
ajst-32482	55	38	has	have	AUX
ajst-32482	55	39	recognized	recognize	VERB
ajst-32482	55	40	the	the	DET
ajst-32482	55	41	antigen	antigen	NOUN
ajst-32482	55	42	presented	present	VERB
ajst-32482	55	43	by	by	ADP
ajst-32482	55	44	mhc	mhc	PROPN
ajst-32482	55	45	.	.	PUNCT
ajst-32482	56	1	108	108	NUM
ajst-32482	56	2	2.3	2.3	NUM
ajst-32482	56	3	cancer	cancer	NOUN
ajst-32482	56	4	cells	cell	NOUN
ajst-32482	56	5	immune	immune	ADJ
ajst-32482	56	6	evasion	evasion	NOUN
ajst-32482	56	7	cancer	cancer	NOUN
ajst-32482	56	8	cells	cell	NOUN
ajst-32482	56	9	can	can	AUX
ajst-32482	56	10	hijack	hijack	VERB
ajst-32482	56	11	immune	immune	ADJ
ajst-32482	56	12	checkpoints	checkpoint	NOUN
ajst-32482	56	13	to	to	PART
ajst-32482	56	14	evade	evade	VERB
ajst-32482	56	15	recognition	recognition	NOUN
ajst-32482	56	16	and	and	CCONJ
ajst-32482	56	17	elimination	elimination	NOUN
ajst-32482	56	18	by	by	ADP
ajst-32482	56	19	the	the	DET
ajst-32482	56	20	immune	immune	ADJ
ajst-32482	56	21	system	system	NOUN
ajst-32482	56	22	,	,	PUNCT
ajst-32482	56	23	with	with	ADP
ajst-32482	56	24	pd-1	pd-1	ADP
ajst-32482	56	25	/	/	SYM
ajst-32482	56	26	pd	pd	ADJ
ajst-32482	56	27	-	-	PROPN
ajst-32482	56	28	l1	l1	PROPN
ajst-32482	56	29	being	be	AUX
ajst-32482	56	30	a	a	DET
ajst-32482	56	31	well	well	ADV
ajst-32482	56	32	-	-	PUNCT
ajst-32482	56	33	documented	document	VERB
ajst-32482	56	34	mechanism	mechanism	NOUN
ajst-32482	56	35	of	of	ADP
ajst-32482	56	36	escape	escape	NOUN
ajst-32482	56	37	.	.	PUNCT
ajst-32482	57	1	a	a	DET
ajst-32482	57	2	pivotal	pivotal	ADJ
ajst-32482	57	3	study	study	NOUN
ajst-32482	57	4	in	in	ADP
ajst-32482	57	5	this	this	DET
ajst-32482	57	6	field	field	NOUN
ajst-32482	57	7	first	first	ADV
ajst-32482	57	8	demonstrated	demonstrate	VERB
ajst-32482	57	9	that	that	SCONJ
ajst-32482	57	10	cancer	cancer	NOUN
ajst-32482	57	11	cells	cell	NOUN
ajst-32482	57	12	can	can	AUX
ajst-32482	57	13	highly	highly	ADV
ajst-32482	57	14	express	express	VERB
ajst-32482	57	15	pd	pd	NOUN
ajst-32482	57	16	-	-	PROPN
ajst-32482	57	17	l1	l1	PROPN
ajst-32482	57	18	to	to	PART
ajst-32482	57	19	evade	evade	VERB
ajst-32482	57	20	t	t	NOUN
ajst-32482	57	21	-	-	PUNCT
ajst-32482	57	22	cell	cell	NOUN
ajst-32482	57	23	attack	attack	NOUN
ajst-32482	57	24	.	.	PUNCT
ajst-32482	58	1	for	for	ADP
ajst-32482	58	2	example	example	NOUN
ajst-32482	58	3	,	,	PUNCT
ajst-32482	58	4	research	research	NOUN
ajst-32482	58	5	has	have	AUX
ajst-32482	58	6	shown	show	VERB
ajst-32482	58	7	that	that	SCONJ
ajst-32482	58	8	in	in	ADP
ajst-32482	58	9	non	non	ADJ
ajst-32482	58	10	-	-	ADJ
ajst-32482	58	11	small	small	ADJ
ajst-32482	58	12	cell	cell	NOUN
ajst-32482	58	13	lung	lung	NOUN
ajst-32482	58	14	cancer	cancer	NOUN
ajst-32482	58	15	and	and	CCONJ
ajst-32482	58	16	other	other	ADJ
ajst-32482	58	17	malignancies	malignancy	NOUN
ajst-32482	58	18	,	,	PUNCT
ajst-32482	58	19	the	the	DET
ajst-32482	58	20	tumor	tumor	NOUN
ajst-32482	58	21	cells	cell	NOUN
ajst-32482	58	22	often	often	ADV
ajst-32482	58	23	regulate	regulate	VERB
ajst-32482	58	24	pd	pd	ADJ
ajst-32482	58	25	-	-	PUNCT
ajst-32482	58	26	l1	l1	PROPN
ajst-32482	58	27	expression	expression	NOUN
ajst-32482	58	28	.	.	PUNCT
ajst-32482	59	1	by	by	ADP
ajst-32482	59	2	doing	do	VERB
ajst-32482	59	3	so	so	ADV
ajst-32482	59	4	,	,	PUNCT
ajst-32482	59	5	they	they	PRON
ajst-32482	59	6	can	can	AUX
ajst-32482	59	7	bind	bind	VERB
ajst-32482	59	8	to	to	ADP
ajst-32482	59	9	pd-1	pd-1	ADJ
ajst-32482	59	10	on	on	ADP
ajst-32482	59	11	infiltrating	infiltrate	VERB
ajst-32482	59	12	t	t	PROPN
ajst-32482	59	13	cells	cell	NOUN
ajst-32482	59	14	in	in	ADP
ajst-32482	59	15	the	the	DET
ajst-32482	59	16	tumor	tumor	NOUN
ajst-32482	59	17	microenvironment	microenvironment	NOUN
ajst-32482	59	18	,	,	PUNCT
ajst-32482	59	19	triggering	trigger	VERB
ajst-32482	59	20	the	the	DET
ajst-32482	59	21	inhibitory	inhibitory	NOUN
ajst-32482	59	22	signaling	signaling	NOUN
ajst-32482	59	23	described	describe	VERB
ajst-32482	59	24	earlier	early	ADV
ajst-32482	59	25	.	.	PUNCT
ajst-32482	60	1	this	this	PRON
ajst-32482	60	2	leads	lead	VERB
ajst-32482	60	3	to	to	ADP
ajst-32482	60	4	the	the	DET
ajst-32482	60	5	dysfunction	dysfunction	NOUN
ajst-32482	60	6	or	or	CCONJ
ajst-32482	60	7	exhaustion	exhaustion	NOUN
ajst-32482	60	8	of	of	ADP
ajst-32482	60	9	t	t	NOUN
ajst-32482	60	10	cells	cell	NOUN
ajst-32482	60	11	,	,	PUNCT
ajst-32482	60	12	allowing	allow	VERB
ajst-32482	60	13	cancer	cancer	NOUN
ajst-32482	60	14	cells	cell	NOUN
ajst-32482	60	15	to	to	PART
ajst-32482	60	16	avoid	avoid	VERB
ajst-32482	60	17	immune	immune	ADJ
ajst-32482	60	18	surveillance	surveillance	NOUN
ajst-32482	60	19	.	.	PUNCT
ajst-32482	61	1	another	another	DET
ajst-32482	61	2	aspect	aspect	NOUN
ajst-32482	61	3	of	of	ADP
ajst-32482	61	4	immune	immune	ADJ
ajst-32482	61	5	evasion	evasion	NOUN
ajst-32482	61	6	involves	involve	VERB
ajst-32482	61	7	the	the	DET
ajst-32482	61	8	interaction	interaction	NOUN
ajst-32482	61	9	between	between	ADP
ajst-32482	61	10	cancer	cancer	NOUN
ajst-32482	61	11	cells	cell	NOUN
ajst-32482	61	12	and	and	CCONJ
ajst-32482	61	13	the	the	DET
ajst-32482	61	14	tumor	tumor	NOUN
ajst-32482	61	15	microenvironment	microenvironment	NOUN
ajst-32482	61	16	.	.	PUNCT
ajst-32482	62	1	cancer	cancer	NOUN
ajst-32482	62	2	cells	cell	NOUN
ajst-32482	62	3	may	may	AUX
ajst-32482	62	4	also	also	ADV
ajst-32482	62	5	induce	induce	VERB
ajst-32482	62	6	surrounding	surround	VERB
ajst-32482	62	7	stromal	stromal	ADJ
ajst-32482	62	8	cells	cell	NOUN
ajst-32482	62	9	,	,	PUNCT
ajst-32482	62	10	such	such	ADJ
ajst-32482	62	11	as	as	ADP
ajst-32482	62	12	macrophages	macrophage	NOUN
ajst-32482	62	13	and	and	CCONJ
ajst-32482	62	14	dendritic	dendritic	ADJ
ajst-32482	62	15	cells	cell	NOUN
ajst-32482	62	16	.	.	PUNCT
ajst-32482	63	1	to	to	PART
ajst-32482	63	2	express	express	VERB
ajst-32482	63	3	pd	pd	NOUN
ajst-32482	63	4	-	-	PUNCT
ajst-32482	63	5	l1	l1	PROPN
ajst-32482	63	6	,	,	PUNCT
ajst-32482	63	7	creating	create	VERB
ajst-32482	63	8	a	a	DET
ajst-32482	63	9	more	more	ADV
ajst-32482	63	10	immunosuppressive	immunosuppressive	ADJ
ajst-32482	63	11	microenvironment	microenvironment	NOUN
ajst-32482	63	12	.	.	PUNCT
ajst-32482	64	1	this	this	DET
ajst-32482	64	2	collective	collective	ADJ
ajst-32482	64	3	up	up	NOUN
ajst-32482	64	4	-	-	PUNCT
ajst-32482	64	5	regulation	regulation	NOUN
ajst-32482	64	6	of	of	ADP
ajst-32482	64	7	pd	pd	PROPN
ajst-32482	64	8	-	-	PROPN
ajst-32482	64	9	l1	l1	PROPN
ajst-32482	64	10	further	far	ADV
ajst-32482	64	11	reinforces	reinforce	VERB
ajst-32482	64	12	the	the	DET
ajst-32482	64	13	“	"	PUNCT
ajst-32482	64	14	brake	brake	NOUN
ajst-32482	64	15	”	"	PUNCT
ajst-32482	64	16	on	on	ADP
ajst-32482	64	17	t	t	PROPN
ajst-32482	64	18	cells	cell	NOUN
ajst-32482	64	19	,	,	PUNCT
ajst-32482	64	20	enabling	enable	VERB
ajst-32482	64	21	cancer	cancer	NOUN
ajst-32482	64	22	cells	cell	NOUN
ajst-32482	64	23	to	to	PART
ajst-32482	64	24	proliferate	proliferate	VERB
ajst-32482	64	25	and	and	CCONJ
ajst-32482	64	26	survive	survive	VERB
ajst-32482	64	27	.	.	PUNCT
ajst-32482	65	1	3	3	X
ajst-32482	65	2	.	.	X
ajst-32482	65	3	the	the	DET
ajst-32482	65	4	role	role	NOUN
ajst-32482	65	5	of	of	ADP
ajst-32482	65	6	immune	immune	ADJ
ajst-32482	65	7	checkpoint	checkpoint	NOUN
ajst-32482	65	8	inhibitor	inhibitor	NOUN
ajst-32482	65	9	drugs	drug	NOUN
ajst-32482	65	10	in	in	ADP
ajst-32482	65	11	solid	solid	ADJ
ajst-32482	65	12	tumor	tumor	NOUN
ajst-32482	65	13	therapy	therapy	NOUN
ajst-32482	65	14	in	in	ADP
ajst-32482	65	15	the	the	DET
ajst-32482	65	16	treatment	treatment	NOUN
ajst-32482	65	17	of	of	ADP
ajst-32482	65	18	solid	solid	ADJ
ajst-32482	65	19	tumors	tumor	NOUN
ajst-32482	65	20	,	,	PUNCT
ajst-32482	65	21	immune	immune	ADJ
ajst-32482	65	22	checkpoint	checkpoint	NOUN
ajst-32482	65	23	inhibitor	inhibitor	NOUN
ajst-32482	65	24	(	(	PUNCT
ajst-32482	65	25	ici	ici	PROPN
ajst-32482	65	26	)	)	PUNCT
ajst-32482	65	27	drugs	drug	NOUN
ajst-32482	65	28	have	have	AUX
ajst-32482	65	29	emerged	emerge	VERB
ajst-32482	65	30	as	as	ADP
ajst-32482	65	31	transformative	transformative	ADJ
ajst-32482	65	32	agents	agent	NOUN
ajst-32482	65	33	,	,	PUNCT
ajst-32482	65	34	reshaping	reshape	VERB
ajst-32482	65	35	therapeutic	therapeutic	ADJ
ajst-32482	65	36	approaches	approach	NOUN
ajst-32482	65	37	for	for	ADP
ajst-32482	65	38	lung	lung	NOUN
ajst-32482	65	39	and	and	CCONJ
ajst-32482	65	40	breast	breast	NOUN
ajst-32482	65	41	cancer	cancer	NOUN
ajst-32482	65	42	.	.	PUNCT
ajst-32482	66	1	for	for	ADP
ajst-32482	66	2	lung	lung	NOUN
ajst-32482	66	3	cancer	cancer	NOUN
ajst-32482	66	4	,	,	PUNCT
ajst-32482	66	5	a	a	DET
ajst-32482	66	6	leading	lead	VERB
ajst-32482	66	7	cause	cause	NOUN
ajst-32482	66	8	of	of	ADP
ajst-32482	66	9	global	global	ADJ
ajst-32482	66	10	cancer	cancer	NOUN
ajst-32482	66	11	-	-	PUNCT
ajst-32482	66	12	related	relate	VERB
ajst-32482	66	13	mortality	mortality	NOUN
ajst-32482	66	14	,	,	PUNCT
ajst-32482	66	15	icis	icis	PROPN
ajst-32482	66	16	have	have	AUX
ajst-32482	66	17	made	make	VERB
ajst-32482	66	18	substantial	substantial	ADJ
ajst-32482	66	19	inroads	inroad	NOUN
ajst-32482	66	20	.	.	PUNCT
ajst-32482	67	1	non	non	ADJ
ajst-32482	67	2	-	-	ADJ
ajst-32482	67	3	small	small	ADJ
ajst-32482	67	4	cell	cell	NOUN
ajst-32482	67	5	lung	lung	NOUN
ajst-32482	67	6	cancer	cancer	NOUN
ajst-32482	67	7	(	(	PUNCT
ajst-32482	67	8	nsclc	nsclc	NOUN
ajst-32482	67	9	)	)	PUNCT
ajst-32482	67	10	,	,	PUNCT
ajst-32482	67	11	accounting	account	VERB
ajst-32482	67	12	for	for	ADP
ajst-32482	67	13	around	around	ADP
ajst-32482	67	14	85	85	NUM
ajst-32482	67	15	%	%	NOUN
ajst-32482	67	16	of	of	ADP
ajst-32482	67	17	lung	lung	NOUN
ajst-32482	67	18	cancer	cancer	NOUN
ajst-32482	67	19	cases	case	NOUN
ajst-32482	67	20	,	,	PUNCT
ajst-32482	67	21	has	have	AUX
ajst-32482	67	22	seen	see	VERB
ajst-32482	67	23	notable	notable	ADJ
ajst-32482	67	24	advancements	advancement	NOUN
ajst-32482	67	25	.	.	PUNCT
ajst-32482	68	1	drugs	drug	NOUN
ajst-32482	68	2	targeting	target	VERB
ajst-32482	68	3	checkpoints	checkpoint	NOUN
ajst-32482	68	4	such	such	ADJ
ajst-32482	68	5	as	as	ADP
ajst-32482	68	6	pd	pd	PROPN
ajst-32482	68	7	1	1	NUM
ajst-32482	68	8	/	/	SYM
ajst-32482	68	9	pd	pd	PROPN
ajst-32482	68	10	l1	l1	PROPN
ajst-32482	68	11	have	have	AUX
ajst-32482	68	12	redefined	redefine	VERB
ajst-32482	68	13	treatment	treatment	NOUN
ajst-32482	68	14	.	.	PUNCT
ajst-32482	69	1	as	as	SCONJ
ajst-32482	69	2	noted	note	VERB
ajst-32482	69	3	in	in	ADP
ajst-32482	69	4	“	"	PUNCT
ajst-32482	69	5	small	small	ADJ
ajst-32482	69	6	-	-	PUNCT
ajst-32482	69	7	molecule	molecule	NOUN
ajst-32482	69	8	inhibitors	inhibitor	NOUN
ajst-32482	69	9	,	,	PUNCT
ajst-32482	69	10	immune	immune	ADJ
ajst-32482	69	11	checkpoint	checkpoint	NOUN
ajst-32482	69	12	inhibitors	inhibitor	NOUN
ajst-32482	69	13	,	,	PUNCT
ajst-32482	69	14	and	and	CCONJ
ajst-32482	69	15	more	more	ADV
ajst-32482	69	16	:	:	PUNCT
ajst-32482	69	17	fdaapproved	fdaapprove	VERB
ajst-32482	69	18	novel	novel	ADJ
ajst-32482	69	19	therapeutic	therapeutic	ADJ
ajst-32482	69	20	drugs	drug	NOUN
ajst-32482	69	21	for	for	ADP
ajst-32482	69	22	solid	solid	ADJ
ajst-32482	69	23	tumors	tumor	NOUN
ajst-32482	69	24	from	from	ADP
ajst-32482	69	25	1991	1991	NUM
ajst-32482	69	26	to	to	ADP
ajst-32482	69	27	2021	2021	NUM
ajst-32482	69	28	”	"	PUNCT
ajst-32482	69	29	,	,	PUNCT
ajst-32482	69	30	in	in	ADP
ajst-32482	69	31	nsclc	nsclc	NOUN
ajst-32482	69	32	treatment	treatment	NOUN
ajst-32482	69	33	,	,	PUNCT
ajst-32482	69	34	these	these	DET
ajst-32482	69	35	icis	icis	NOUN
ajst-32482	69	36	can	can	AUX
ajst-32482	69	37	reactivate	reactivate	VERB
ajst-32482	69	38	the	the	DET
ajst-32482	69	39	immune	immune	ADJ
ajst-32482	69	40	system	system	NOUN
ajst-32482	69	41	to	to	PART
ajst-32482	69	42	combat	combat	VERB
ajst-32482	69	43	cancer	cancer	NOUN
ajst-32482	69	44	cells	cell	NOUN
ajst-32482	69	45	.	.	PUNCT
ajst-32482	70	1	clinical	clinical	ADJ
ajst-32482	70	2	data	datum	NOUN
ajst-32482	70	3	from	from	ADP
ajst-32482	70	4	relevant	relevant	ADJ
ajst-32482	70	5	trials	trial	NOUN
ajst-32482	70	6	show	show	VERB
ajst-32482	70	7	improved	improve	VERB
ajst-32482	70	8	objective	objective	ADJ
ajst-32482	70	9	response	response	NOUN
ajst-32482	70	10	rates	rate	NOUN
ajst-32482	70	11	in	in	ADP
ajst-32482	70	12	some	some	DET
ajst-32482	70	13	patients	patient	NOUN
ajst-32482	71	1	[	[	X
ajst-32482	71	2	5	5	NUM
ajst-32482	71	3	]	]	PUNCT
ajst-32482	71	4	.	.	PUNCT
ajst-32482	72	1	for	for	ADP
ajst-32482	72	2	example	example	NOUN
ajst-32482	72	3	,	,	PUNCT
ajst-32482	72	4	certain	certain	ADJ
ajst-32482	72	5	studies	study	NOUN
ajst-32482	72	6	highlight	highlight	VERB
ajst-32482	72	7	prolonged	prolonged	ADJ
ajst-32482	72	8	progression	progression	NOUN
ajst-32482	72	9	-	-	PUNCT
ajst-32482	72	10	free	free	ADJ
ajst-32482	72	11	survival	survival	NOUN
ajst-32482	72	12	,	,	PUNCT
ajst-32482	72	13	granting	grant	VERB
ajst-32482	72	14	patients	patient	NOUN
ajst-32482	72	15	more	more	ADJ
ajst-32482	72	16	time	time	NOUN
ajst-32482	72	17	with	with	ADP
ajst-32482	72	18	stable	stable	ADJ
ajst-32482	72	19	disease	disease	NOUN
ajst-32482	72	20	.	.	PUNCT
ajst-32482	73	1	in	in	ADP
ajst-32482	73	2	breast	breast	NOUN
ajst-32482	73	3	cancer	cancer	NOUN
ajst-32482	73	4	,	,	PUNCT
ajst-32482	73	5	icis	icis	PROPN
ajst-32482	73	6	are	be	AUX
ajst-32482	73	7	also	also	ADV
ajst-32482	73	8	carving	carve	VERB
ajst-32482	73	9	out	out	ADP
ajst-32482	73	10	a	a	DET
ajst-32482	73	11	role	role	NOUN
ajst-32482	73	12	.	.	PUNCT
ajst-32482	74	1	while	while	SCONJ
ajst-32482	74	2	traditional	traditional	ADJ
ajst-32482	74	3	cytotoxic	cytotoxic	ADJ
ajst-32482	74	4	drugs	drug	NOUN
ajst-32482	74	5	and	and	CCONJ
ajst-32482	74	6	hormonal	hormonal	ADJ
ajst-32482	74	7	therapies	therapy	NOUN
ajst-32482	74	8	remain	remain	VERB
ajst-32482	74	9	pivotal	pivotal	ADJ
ajst-32482	74	10	,	,	PUNCT
ajst-32482	74	11	icis	icis	PROPN
ajst-32482	74	12	offer	offer	VERB
ajst-32482	74	13	new	new	ADJ
ajst-32482	74	14	possibilities	possibility	NOUN
ajst-32482	74	15	,	,	PUNCT
ajst-32482	74	16	especially	especially	ADV
ajst-32482	74	17	in	in	ADP
ajst-32482	74	18	specific	specific	ADJ
ajst-32482	74	19	subtypes	subtype	NOUN
ajst-32482	74	20	.	.	PUNCT
ajst-32482	75	1	for	for	ADP
ajst-32482	75	2	hormone	hormone	NOUN
ajst-32482	75	3	receptor	receptor	NOUN
ajst-32482	75	4	(	(	PUNCT
ajst-32482	75	5	hr	hr	NOUN
ajst-32482	75	6	)	)	PUNCT
ajst-32482	75	7	positive	positive	ADJ
ajst-32482	75	8	breast	breast	NOUN
ajst-32482	75	9	cancers	cancer	NOUN
ajst-32482	75	10	,	,	PUNCT
ajst-32482	75	11	which	which	PRON
ajst-32482	75	12	constitute	constitute	VERB
ajst-32482	75	13	a	a	DET
ajst-32482	75	14	large	large	ADJ
ajst-32482	75	15	share	share	NOUN
ajst-32482	75	16	of	of	ADP
ajst-32482	75	17	cases	case	NOUN
ajst-32482	75	18	,	,	PUNCT
ajst-32482	75	19	the	the	DET
ajst-32482	75	20	exploration	exploration	NOUN
ajst-32482	75	21	of	of	ADP
ajst-32482	75	22	combining	combine	VERB
ajst-32482	75	23	icis	icis	NOUN
ajst-32482	75	24	with	with	ADP
ajst-32482	75	25	other	other	ADJ
ajst-32482	75	26	treatments	treatment	NOUN
ajst-32482	75	27	is	be	AUX
ajst-32482	75	28	underway	underway	ADJ
ajst-32482	75	29	.	.	PUNCT
ajst-32482	76	1	as	as	SCONJ
ajst-32482	76	2	referenced	reference	VERB
ajst-32482	76	3	in	in	ADP
ajst-32482	76	4	the	the	DET
ajst-32482	76	5	same	same	ADJ
ajst-32482	76	6	source	source	NOUN
ajst-32482	76	7	,	,	PUNCT
ajst-32482	76	8	early	early	ADJ
ajst-32482	76	9	research	research	NOUN
ajst-32482	76	10	suggests	suggest	VERB
ajst-32482	76	11	that	that	SCONJ
ajst-32482	76	12	icis	icis	PROPN
ajst-32482	76	13	can	can	AUX
ajst-32482	76	14	enhance	enhance	VERB
ajst-32482	76	15	the	the	DET
ajst-32482	76	16	immune	immune	ADJ
ajst-32482	76	17	system	system	NOUN
ajst-32482	76	18	’s	’s	PART
ajst-32482	76	19	capacity	capacity	NOUN
ajst-32482	76	20	to	to	PART
ajst-32482	76	21	target	target	VERB
ajst-32482	76	22	cancer	cancer	NOUN
ajst-32482	76	23	cells	cell	NOUN
ajst-32482	76	24	in	in	ADP
ajst-32482	76	25	select	select	ADJ
ajst-32482	76	26	scenarios	scenario	NOUN
ajst-32482	76	27	,	,	PUNCT
ajst-32482	76	28	potentially	potentially	ADV
ajst-32482	76	29	improving	improve	VERB
ajst-32482	76	30	treatment	treatment	NOUN
ajst-32482	76	31	efficacy	efficacy	NOUN
ajst-32482	76	32	[	[	X
ajst-32482	76	33	5	5	NUM
ajst-32482	76	34	]	]	PUNCT
ajst-32482	76	35	.	.	PUNCT
ajst-32482	77	1	4	4	X
ajst-32482	77	2	.	.	X
ajst-32482	77	3	potential	potential	ADJ
ajst-32482	77	4	challenges	challenge	NOUN
ajst-32482	77	5	cancer	cancer	NOUN
ajst-32482	77	6	immunotherapy	immunotherapy	NOUN
ajst-32482	77	7	,	,	PUNCT
ajst-32482	77	8	particularly	particularly	ADV
ajst-32482	77	9	the	the	DET
ajst-32482	77	10	use	use	NOUN
ajst-32482	77	11	of	of	ADP
ajst-32482	77	12	immune	immune	ADJ
ajst-32482	77	13	checkpoint	checkpoint	NOUN
ajst-32482	77	14	inhibitors	inhibitor	NOUN
ajst-32482	77	15	(	(	PUNCT
ajst-32482	77	16	icis	icis	NOUN
ajst-32482	77	17	)	)	PUNCT
ajst-32482	77	18	,	,	PUNCT
ajst-32482	77	19	has	have	AUX
ajst-32482	77	20	significantly	significantly	ADV
ajst-32482	77	21	transformed	transform	VERB
ajst-32482	77	22	the	the	DET
ajst-32482	77	23	treatment	treatment	NOUN
ajst-32482	77	24	of	of	ADP
ajst-32482	77	25	cancer	cancer	NOUN
ajst-32482	77	26	.	.	PUNCT
ajst-32482	78	1	but	but	CCONJ
ajst-32482	78	2	there	there	PRON
ajst-32482	78	3	are	be	VERB
ajst-32482	78	4	significant	significant	ADJ
ajst-32482	78	5	challenges	challenge	NOUN
ajst-32482	78	6	that	that	PRON
ajst-32482	78	7	stop	stop	VERB
ajst-32482	78	8	them	they	PRON
ajst-32482	78	9	from	from	ADP
ajst-32482	78	10	working	work	VERB
ajst-32482	78	11	better	well	ADV
ajst-32482	78	12	for	for	ADP
ajst-32482	78	13	more	more	ADJ
ajst-32482	78	14	people	people	NOUN
ajst-32482	78	15	,	,	PUNCT
ajst-32482	78	16	like	like	ADP
ajst-32482	78	17	drug	drug	NOUN
ajst-32482	78	18	resistance	resistance	NOUN
ajst-32482	78	19	,	,	PUNCT
ajst-32482	78	20	side	side	NOUN
ajst-32482	78	21	effects	effect	NOUN
ajst-32482	78	22	,	,	PUNCT
ajst-32482	78	23	and	and	CCONJ
ajst-32482	78	24	only	only	ADV
ajst-32482	78	25	helping	help	VERB
ajst-32482	78	26	some	some	DET
ajst-32482	78	27	patients	patient	NOUN
ajst-32482	78	28	.	.	PUNCT
ajst-32482	79	1	resistance	resistance	NOUN
ajst-32482	79	2	to	to	ADP
ajst-32482	79	3	icis	icis	PROPN
ajst-32482	79	4	happens	happen	VERB
ajst-32482	79	5	because	because	SCONJ
ajst-32482	79	6	cancer	cancer	NOUN
ajst-32482	79	7	cells	cell	NOUN
ajst-32482	79	8	find	find	VERB
ajst-32482	79	9	ways	way	NOUN
ajst-32482	79	10	to	to	PART
ajst-32482	79	11	escape	escape	VERB
ajst-32482	79	12	the	the	DET
ajst-32482	79	13	immune	immune	ADJ
ajst-32482	79	14	attack	attack	NOUN
ajst-32482	79	15	.	.	PUNCT
ajst-32482	80	1	initially	initially	ADV
ajst-32482	80	2	,	,	PUNCT
ajst-32482	80	3	icis	icis	PROPN
ajst-32482	80	4	work	work	NOUN
ajst-32482	80	5	by	by	ADP
ajst-32482	80	6	activating	activate	VERB
ajst-32482	80	7	the	the	DET
ajst-32482	80	8	immune	immune	ADJ
ajst-32482	80	9	system	system	NOUN
ajst-32482	80	10	to	to	PART
ajst-32482	80	11	fight	fight	VERB
ajst-32482	80	12	tumors	tumor	NOUN
ajst-32482	80	13	.	.	PUNCT
ajst-32482	81	1	however	however	ADV
ajst-32482	81	2	,	,	PUNCT
ajst-32482	81	3	cancer	cancer	NOUN
ajst-32482	81	4	cells	cell	NOUN
ajst-32482	81	5	may	may	AUX
ajst-32482	81	6	hide	hide	VERB
ajst-32482	81	7	over	over	ADP
ajst-32482	81	8	time	time	NOUN
ajst-32482	81	9	by	by	ADP
ajst-32482	81	10	altering	alter	VERB
ajst-32482	81	11	the	the	DET
ajst-32482	81	12	way	way	NOUN
ajst-32482	81	13	they	they	PRON
ajst-32482	81	14	present	present	VERB
ajst-32482	81	15	antigens	antigen	NOUN
ajst-32482	81	16	that	that	SCONJ
ajst-32482	81	17	the	the	DET
ajst-32482	81	18	immune	immune	ADJ
ajst-32482	81	19	system	system	NOUN
ajst-32482	81	20	recognizes	recognize	VERB
ajst-32482	81	21	.	.	PUNCT
ajst-32482	82	1	alternatively	alternatively	ADV
ajst-32482	82	2	,	,	PUNCT
ajst-32482	82	3	they	they	PRON
ajst-32482	82	4	may	may	AUX
ajst-32482	82	5	initiate	initiate	VERB
ajst-32482	82	6	new	new	ADJ
ajst-32482	82	7	immunosuppressive	immunosuppressive	ADJ
ajst-32482	82	8	pathways	pathway	NOUN
ajst-32482	82	9	,	,	PUNCT
ajst-32482	82	10	such	such	ADJ
ajst-32482	82	11	as	as	ADP
ajst-32482	82	12	activating	activate	VERB
ajst-32482	82	13	other	other	ADJ
ajst-32482	82	14	checkpoint	checkpoint	NOUN
ajst-32482	82	15	molecules	molecule	NOUN
ajst-32482	82	16	,	,	PUNCT
ajst-32482	82	17	including	include	VERB
ajst-32482	82	18	tim-3	tim-3	NUM
ajst-32482	82	19	or	or	CCONJ
ajst-32482	82	20	lag-3	lag-3	X
ajst-32482	82	21	.	.	PUNCT
ajst-32482	83	1	take	take	VERB
ajst-32482	83	2	melanoma	melanoma	NOUN
ajst-32482	83	3	as	as	ADP
ajst-32482	83	4	an	an	DET
ajst-32482	83	5	example	example	NOUN
ajst-32482	83	6	.	.	PUNCT
ajst-32482	84	1	the	the	DET
ajst-32482	84	2	tumors	tumor	NOUN
ajst-32482	84	3	might	might	AUX
ajst-32482	84	4	lose	lose	VERB
ajst-32482	84	5	mhc	mhc	PROPN
ajst-32482	84	6	molecules	molecule	NOUN
ajst-32482	84	7	,	,	PUNCT
ajst-32482	84	8	so	so	SCONJ
ajst-32482	84	9	t	t	NOUN
ajst-32482	84	10	cells	cell	NOUN
ajst-32482	84	11	ca	can	AUX
ajst-32482	84	12	n't	not	PART
ajst-32482	84	13	find	find	VERB
ajst-32482	84	14	and	and	CCONJ
ajst-32482	84	15	attack	attack	VERB
ajst-32482	84	16	them	they	PRON
ajst-32482	84	17	anymore	anymore	ADV
ajst-32482	84	18	.	.	PUNCT
ajst-32482	85	1	this	this	DET
ajst-32482	85	2	immune	immune	ADJ
ajst-32482	85	3	evasion	evasion	NOUN
ajst-32482	85	4	diminishes	diminish	VERB
ajst-32482	85	5	the	the	DET
ajst-32482	85	6	initial	initial	ADJ
ajst-32482	85	7	beneficial	beneficial	ADJ
ajst-32482	85	8	effect	effect	NOUN
ajst-32482	85	9	of	of	ADP
ajst-32482	85	10	icis	icis	PROPN
ajst-32482	85	11	,	,	PUNCT
ajst-32482	85	12	as	as	SCONJ
ajst-32482	85	13	the	the	DET
ajst-32482	85	14	immune	immune	ADJ
ajst-32482	85	15	system	system	NOUN
ajst-32482	85	16	struggles	struggle	VERB
ajst-32482	85	17	to	to	PART
ajst-32482	85	18	target	target	VERB
ajst-32482	85	19	the	the	DET
ajst-32482	85	20	altered	altered	ADJ
ajst-32482	85	21	cancer	cancer	NOUN
ajst-32482	85	22	cells	cell	NOUN
ajst-32482	86	1	[	[	X
ajst-32482	86	2	6	6	NUM
ajst-32482	86	3	]	]	PUNCT
ajst-32482	86	4	effectively	effectively	ADV
ajst-32482	86	5	.	.	PUNCT
ajst-32482	87	1	icis	icis	PROPN
ajst-32482	87	2	activate	activate	VERB
ajst-32482	87	3	the	the	DET
ajst-32482	87	4	immune	immune	ADJ
ajst-32482	87	5	system	system	NOUN
ajst-32482	87	6	,	,	PUNCT
ajst-32482	87	7	but	but	CCONJ
ajst-32482	87	8	this	this	PRON
ajst-32482	87	9	can	can	AUX
ajst-32482	87	10	lead	lead	VERB
ajst-32482	87	11	to	to	ADP
ajst-32482	87	12	excessive	excessive	ADJ
ajst-32482	87	13	activity	activity	NOUN
ajst-32482	87	14	,	,	PUNCT
ajst-32482	87	15	causing	cause	VERB
ajst-32482	87	16	immune	immune	NOUN
ajst-32482	87	17	-	-	PUNCT
ajst-32482	87	18	related	relate	VERB
ajst-32482	87	19	side	side	NOUN
ajst-32482	87	20	effects	effect	NOUN
ajst-32482	87	21	.	.	PUNCT
ajst-32482	88	1	these	these	PRON
ajst-32482	88	2	include	include	VERB
ajst-32482	88	3	pneumonitis	pneumonitis	NOUN
ajst-32482	88	4	,	,	PUNCT
ajst-32482	88	5	a	a	DET
ajst-32482	88	6	lung	lung	NOUN
ajst-32482	88	7	inflammation	inflammation	NOUN
ajst-32482	88	8	that	that	PRON
ajst-32482	88	9	causes	cause	VERB
ajst-32482	88	10	coughing	cough	VERB
ajst-32482	88	11	and	and	CCONJ
ajst-32482	88	12	shortness	shortness	NOUN
ajst-32482	88	13	of	of	ADP
ajst-32482	88	14	breath	breath	NOUN
ajst-32482	88	15	,	,	PUNCT
ajst-32482	88	16	and	and	CCONJ
ajst-32482	88	17	colitis	colitis	NOUN
ajst-32482	88	18	,	,	PUNCT
ajst-32482	88	19	where	where	SCONJ
ajst-32482	88	20	the	the	DET
ajst-32482	88	21	intestines	intestine	NOUN
ajst-32482	88	22	become	become	VERB
ajst-32482	88	23	irritated	irritated	ADJ
ajst-32482	88	24	,	,	PUNCT
ajst-32482	88	25	leading	lead	VERB
ajst-32482	88	26	to	to	ADP
ajst-32482	88	27	diarrhea	diarrhea	NOUN
ajst-32482	88	28	and	and	CCONJ
ajst-32482	88	29	stomach	stomach	NOUN
ajst-32482	88	30	pain	pain	NOUN
ajst-32482	88	31	.	.	PUNCT
ajst-32482	89	1	once	once	ADV
ajst-32482	89	2	ramped	ramp	VERB
ajst-32482	89	3	up	up	ADP
ajst-32482	89	4	,	,	PUNCT
ajst-32482	89	5	the	the	DET
ajst-32482	89	6	immune	immune	ADJ
ajst-32482	89	7	system	system	NOUN
ajst-32482	89	8	may	may	AUX
ajst-32482	89	9	accidentally	accidentally	ADV
ajst-32482	89	10	attack	attack	VERB
ajst-32482	89	11	healthy	healthy	ADJ
ajst-32482	89	12	tissues	tissue	NOUN
ajst-32482	89	13	,	,	PUNCT
ajst-32482	89	14	such	such	ADJ
ajst-32482	89	15	as	as	ADP
ajst-32482	89	16	the	the	DET
ajst-32482	89	17	lungs	lung	NOUN
ajst-32482	89	18	or	or	CCONJ
ajst-32482	89	19	gut	gut	NOUN
ajst-32482	89	20	,	,	PUNCT
ajst-32482	89	21	because	because	SCONJ
ajst-32482	89	22	they	they	PRON
ajst-32482	89	23	share	share	VERB
ajst-32482	89	24	some	some	DET
ajst-32482	89	25	similar	similar	ADJ
ajst-32482	89	26	antigens	antigen	NOUN
ajst-32482	89	27	with	with	ADP
ajst-32482	89	28	tumors	tumor	NOUN
ajst-32482	89	29	.	.	PUNCT
ajst-32482	90	1	doctors	doctor	NOUN
ajst-32482	90	2	often	often	ADV
ajst-32482	90	3	use	use	VERB
ajst-32482	90	4	immunosuppressive	immunosuppressive	ADJ
ajst-32482	90	5	drugs	drug	NOUN
ajst-32482	90	6	,	,	PUNCT
ajst-32482	90	7	109	109	NUM
ajst-32482	90	8	such	such	ADJ
ajst-32482	90	9	as	as	ADP
ajst-32482	90	10	corticosteroids	corticosteroid	NOUN
ajst-32482	90	11	,	,	PUNCT
ajst-32482	90	12	to	to	PART
ajst-32482	90	13	manage	manage	VERB
ajst-32482	90	14	these	these	DET
ajst-32482	90	15	side	side	NOUN
ajst-32482	90	16	effects	effect	NOUN
ajst-32482	90	17	.	.	PUNCT
ajst-32482	91	1	however	however	ADV
ajst-32482	91	2	,	,	PUNCT
ajst-32482	91	3	these	these	PRON
ajst-32482	91	4	can	can	AUX
ajst-32482	91	5	reduce	reduce	VERB
ajst-32482	91	6	the	the	DET
ajst-32482	91	7	effectiveness	effectiveness	NOUN
ajst-32482	91	8	of	of	ADP
ajst-32482	91	9	icis	icis	NOUN
ajst-32482	91	10	and	and	CCONJ
ajst-32482	91	11	impact	impact	NOUN
ajst-32482	91	12	patients	patient	NOUN
ajst-32482	91	13	'	'	PART
ajst-32482	91	14	daily	daily	ADJ
ajst-32482	91	15	lives	life	NOUN
ajst-32482	91	16	.	.	PUNCT
ajst-32482	92	1	icis	icis	PROPN
ajst-32482	92	2	are	be	AUX
ajst-32482	92	3	most	most	ADV
ajst-32482	92	4	effective	effective	ADJ
ajst-32482	92	5	for	for	ADP
ajst-32482	92	6	patients	patient	NOUN
ajst-32482	92	7	with	with	ADP
ajst-32482	92	8	specific	specific	ADJ
ajst-32482	92	9	biomarkers	biomarker	NOUN
ajst-32482	92	10	.	.	PUNCT
ajst-32482	93	1	p	p	X
ajst-32482	93	2	-	-	PUNCT
ajst-32482	93	3	l1	l1	PROPN
ajst-32482	93	4	positivity	positivity	NOUN
ajst-32482	93	5	is	be	AUX
ajst-32482	93	6	a	a	DET
ajst-32482	93	7	big	big	ADJ
ajst-32482	93	8	one	one	NOUN
ajst-32482	93	9	.	.	PUNCT
ajst-32482	94	1	tumors	tumor	NOUN
ajst-32482	94	2	with	with	ADP
ajst-32482	94	3	high	high	ADJ
ajst-32482	94	4	pd	pd	PROPN
ajst-32482	94	5	-	-	PUNCT
ajst-32482	94	6	l1	l1	PROPN
ajst-32482	94	7	have	have	VERB
ajst-32482	94	8	more	more	ADJ
ajst-32482	94	9	“	"	PUNCT
ajst-32482	94	10	targets	target	NOUN
ajst-32482	94	11	”	"	PUNCT
ajst-32482	94	12	for	for	SCONJ
ajst-32482	94	13	icis	icis	NOUN
ajst-32482	94	14	to	to	PART
ajst-32482	94	15	block	block	VERB
ajst-32482	94	16	,	,	PUNCT
ajst-32482	94	17	so	so	SCONJ
ajst-32482	94	18	t	t	PROPN
ajst-32482	94	19	-	-	PUNCT
ajst-32482	94	20	cells	cell	NOUN
ajst-32482	94	21	get	get	AUX
ajst-32482	94	22	activated	activate	VERB
ajst-32482	94	23	better	well	ADV
ajst-32482	94	24	.	.	PUNCT
ajst-32482	95	1	in	in	ADP
ajst-32482	95	2	non	non	ADJ
ajst-32482	95	3	-	-	ADJ
ajst-32482	95	4	small	small	ADJ
ajst-32482	95	5	cell	cell	NOUN
ajst-32482	95	6	lung	lung	NOUN
ajst-32482	95	7	cancer	cancer	NOUN
ajst-32482	95	8	,	,	PUNCT
ajst-32482	95	9	patients	patient	NOUN
ajst-32482	95	10	with	with	ADP
ajst-32482	95	11	pd	pd	PROPN
ajst-32482	95	12	-	-	PUNCT
ajst-32482	95	13	l1	l1	PROPN
ajst-32482	95	14	-	-	PUNCT
ajst-32482	95	15	positive	positive	ADJ
ajst-32482	95	16	tumors	tumor	NOUN
ajst-32482	95	17	respond	respond	VERB
ajst-32482	95	18	better	well	ADV
ajst-32482	95	19	to	to	ADP
ajst-32482	95	20	pd-1	pd-1	ADP
ajst-32482	95	21	/	/	SYM
ajst-32482	95	22	pd	pd	ADJ
ajst-32482	95	23	-	-	PUNCT
ajst-32482	95	24	l1	l1	PROPN
ajst-32482	95	25	inhibitors	inhibitor	NOUN
ajst-32482	95	26	;	;	PUNCT
ajst-32482	95	27	additionally	additionally	ADV
ajst-32482	95	28	,	,	PUNCT
ajst-32482	95	29	factors	factor	NOUN
ajst-32482	95	30	such	such	ADJ
ajst-32482	95	31	as	as	ADP
ajst-32482	95	32	tumor	tumor	NOUN
ajst-32482	95	33	mutational	mutational	ADJ
ajst-32482	95	34	burden	burden	NOUN
ajst-32482	95	35	and	and	CCONJ
ajst-32482	95	36	microsatellite	microsatellite	ADJ
ajst-32482	95	37	instability	instability	NOUN
ajst-32482	95	38	also	also	ADV
ajst-32482	95	39	play	play	VERB
ajst-32482	95	40	a	a	DET
ajst-32482	95	41	role	role	NOUN
ajst-32482	95	42	.	.	PUNCT
ajst-32482	96	1	tumors	tumor	NOUN
ajst-32482	96	2	with	with	ADP
ajst-32482	96	3	high	high	ADJ
ajst-32482	96	4	tmb	tmb	PROPN
ajst-32482	96	5	or	or	CCONJ
ajst-32482	96	6	msi	msi	PROPN
ajst-32482	96	7	-	-	PROPN
ajst-32482	96	8	h	h	NOUN
ajst-32482	96	9	have	have	VERB
ajst-32482	96	10	more	more	ADJ
ajst-32482	96	11	neoantigens	neoantigen	NOUN
ajst-32482	96	12	,	,	PUNCT
ajst-32482	96	13	allowing	allow	VERB
ajst-32482	96	14	the	the	DET
ajst-32482	96	15	immune	immune	ADJ
ajst-32482	96	16	system	system	NOUN
ajst-32482	96	17	to	to	PART
ajst-32482	96	18	recognize	recognize	VERB
ajst-32482	96	19	them	they	PRON
ajst-32482	96	20	more	more	ADV
ajst-32482	96	21	easily	easily	ADV
ajst-32482	96	22	.	.	PUNCT
ajst-32482	97	1	therefore	therefore	ADV
ajst-32482	97	2	,	,	PUNCT
ajst-32482	97	3	patients	patient	NOUN
ajst-32482	97	4	without	without	ADP
ajst-32482	97	5	these	these	DET
ajst-32482	97	6	markers	marker	NOUN
ajst-32482	97	7	typically	typically	ADV
ajst-32482	97	8	do	do	AUX
ajst-32482	97	9	n't	not	PART
ajst-32482	97	10	derive	derive	VERB
ajst-32482	97	11	significant	significant	ADJ
ajst-32482	97	12	benefit	benefit	NOUN
ajst-32482	97	13	,	,	PUNCT
ajst-32482	97	14	which	which	PRON
ajst-32482	97	15	means	mean	VERB
ajst-32482	97	16	icis	icis	PROPN
ajst-32482	97	17	can	can	AUX
ajst-32482	97	18	only	only	ADV
ajst-32482	97	19	help	help	VERB
ajst-32482	97	20	a	a	DET
ajst-32482	97	21	limited	limited	ADJ
ajst-32482	97	22	number	number	NOUN
ajst-32482	97	23	of	of	ADP
ajst-32482	97	24	people	people	NOUN
ajst-32482	97	25	.	.	PUNCT
ajst-32482	98	1	5	5	X
ajst-32482	98	2	.	.	X
ajst-32482	98	3	future	future	ADJ
ajst-32482	98	4	research	research	NOUN
ajst-32482	98	5	directions	direction	NOUN
ajst-32482	98	6	of	of	ADP
ajst-32482	98	7	immune	immune	ADJ
ajst-32482	98	8	checkpoint	checkpoint	NOUN
ajst-32482	98	9	inhibitors	inhibitor	NOUN
ajst-32482	98	10	immune	immune	ADJ
ajst-32482	98	11	checkpoint	checkpoint	NOUN
ajst-32482	98	12	inhibitors	inhibitor	NOUN
ajst-32482	98	13	have	have	AUX
ajst-32482	98	14	revolutionized	revolutionize	VERB
ajst-32482	98	15	cancer	cancer	NOUN
ajst-32482	98	16	treatment	treatment	NOUN
ajst-32482	98	17	over	over	ADP
ajst-32482	98	18	the	the	DET
ajst-32482	98	19	past	past	ADJ
ajst-32482	98	20	decade	decade	NOUN
ajst-32482	98	21	,	,	PUNCT
ajst-32482	98	22	but	but	CCONJ
ajst-32482	98	23	their	their	PRON
ajst-32482	98	24	effectiveness	effectiveness	NOUN
ajst-32482	98	25	is	be	AUX
ajst-32482	98	26	still	still	ADV
ajst-32482	98	27	limited	limit	VERB
ajst-32482	98	28	in	in	ADP
ajst-32482	98	29	many	many	ADJ
ajst-32482	98	30	cases	case	NOUN
ajst-32482	98	31	.	.	PUNCT
ajst-32482	99	1	to	to	PART
ajst-32482	99	2	unlock	unlock	VERB
ajst-32482	99	3	their	their	PRON
ajst-32482	99	4	full	full	ADJ
ajst-32482	99	5	potential	potential	NOUN
ajst-32482	99	6	,	,	PUNCT
ajst-32482	99	7	three	three	NUM
ajst-32482	99	8	research	research	NOUN
ajst-32482	99	9	directions	direction	NOUN
ajst-32482	99	10	deserve	deserve	VERB
ajst-32482	99	11	more	more	ADJ
ajst-32482	99	12	attention	attention	NOUN
ajst-32482	99	13	.	.	PUNCT
ajst-32482	100	1	5.1	5.1	NUM
ajst-32482	100	2	combined	combine	VERB
ajst-32482	100	3	therapies	therapy	NOUN
ajst-32482	100	4	mixing	mix	VERB
ajst-32482	100	5	immune	immune	ADJ
ajst-32482	100	6	checkpoint	checkpoint	NOUN
ajst-32482	100	7	inhibitors	inhibitor	NOUN
ajst-32482	100	8	with	with	ADP
ajst-32482	100	9	other	other	ADJ
ajst-32482	100	10	treatments	treatment	NOUN
ajst-32482	100	11	has	have	AUX
ajst-32482	100	12	become	become	VERB
ajst-32482	100	13	a	a	DET
ajst-32482	100	14	hot	hot	ADJ
ajst-32482	100	15	topic	topic	NOUN
ajst-32482	100	16	,	,	PUNCT
ajst-32482	100	17	as	as	SCONJ
ajst-32482	100	18	it	it	PRON
ajst-32482	100	19	often	often	ADV
ajst-32482	100	20	boosts	boost	VERB
ajst-32482	100	21	anti	anti	ADJ
ajst-32482	100	22	-	-	ADJ
ajst-32482	100	23	tumor	tumor	ADJ
ajst-32482	100	24	effects	effect	NOUN
ajst-32482	100	25	.	.	PUNCT
ajst-32482	101	1	at	at	ADP
ajst-32482	101	2	the	the	DET
ajst-32482	101	3	2024	2024	NUM
ajst-32482	101	4	european	european	ADJ
ajst-32482	101	5	society	society	NOUN
ajst-32482	101	6	of	of	ADP
ajst-32482	101	7	medical	medical	ADJ
ajst-32482	101	8	oncology	oncology	NOUN
ajst-32482	101	9	(	(	PUNCT
ajst-32482	101	10	esmo	esmo	NOUN
ajst-32482	101	11	)	)	PUNCT
ajst-32482	101	12	congress	congress	PROPN
ajst-32482	101	13	,	,	PUNCT
ajst-32482	101	14	researchers	researcher	NOUN
ajst-32482	101	15	presented	present	VERB
ajst-32482	101	16	a	a	DET
ajst-32482	101	17	study	study	NOUN
ajst-32482	101	18	on	on	ADP
ajst-32482	101	19	non	non	ADJ
ajst-32482	101	20	-	-	ADJ
ajst-32482	101	21	small	small	ADJ
ajst-32482	101	22	-	-	PUNCT
ajst-32482	101	23	cell	cell	NOUN
ajst-32482	101	24	lung	lung	NOUN
ajst-32482	101	25	cancer	cancer	NOUN
ajst-32482	101	26	(	(	PUNCT
ajst-32482	101	27	nsclc	nsclc	NOUN
ajst-32482	101	28	)	)	PUNCT
ajst-32482	101	29	patients	patient	NOUN
ajst-32482	101	30	,	,	PUNCT
ajst-32482	101	31	showing	show	VERB
ajst-32482	101	32	that	that	SCONJ
ajst-32482	101	33	when	when	SCONJ
ajst-32482	101	34	nivolumab	nivolumab	NOUN
ajst-32482	101	35	,	,	PUNCT
ajst-32482	101	36	relatlimab	relatlimab	NOUN
ajst-32482	101	37	,	,	PUNCT
ajst-32482	101	38	and	and	CCONJ
ajst-32482	101	39	platinum	platinum	NOUN
ajst-32482	101	40	-	-	PUNCT
ajst-32482	101	41	based	base	VERB
ajst-32482	101	42	doublet	doublet	ADJ
ajst-32482	101	43	chemotherapy	chemotherapy	NOUN
ajst-32482	101	44	were	be	AUX
ajst-32482	101	45	used	use	VERB
ajst-32482	101	46	together	together	ADV
ajst-32482	101	47	,	,	PUNCT
ajst-32482	101	48	the	the	DET
ajst-32482	101	49	objective	objective	ADJ
ajst-32482	101	50	response	response	NOUN
ajst-32482	101	51	rate	rate	NOUN
ajst-32482	101	52	reached	reach	VERB
ajst-32482	101	53	51.3	51.3	NUM
ajst-32482	101	54	%	%	NOUN
ajst-32482	101	55	,	,	PUNCT
ajst-32482	101	56	significantly	significantly	ADV
ajst-32482	101	57	higher	high	ADJ
ajst-32482	101	58	than	than	ADP
ajst-32482	101	59	the	the	DET
ajst-32482	101	60	43.7	43.7	NUM
ajst-32482	101	61	%	%	NOUN
ajst-32482	101	62	achieved	achieve	VERB
ajst-32482	101	63	with	with	ADP
ajst-32482	101	64	nivolumab	nivolumab	NOUN
ajst-32482	101	65	plus	plus	CCONJ
ajst-32482	101	66	chemotherapy	chemotherapy	NOUN
ajst-32482	101	67	alone	alone	ADV
ajst-32482	101	68	.	.	PUNCT
ajst-32482	102	1	besides	besides	SCONJ
ajst-32482	102	2	chemotherapy	chemotherapy	NOUN
ajst-32482	102	3	,	,	PUNCT
ajst-32482	102	4	radiotherapy	radiotherapy	NOUN
ajst-32482	102	5	also	also	ADV
ajst-32482	102	6	works	work	VERB
ajst-32482	102	7	in	in	ADP
ajst-32482	102	8	conjunction	conjunction	NOUN
ajst-32482	102	9	with	with	ADP
ajst-32482	102	10	these	these	DET
ajst-32482	102	11	inhibitors	inhibitor	NOUN
ajst-32482	102	12	by	by	ADP
ajst-32482	102	13	helping	help	VERB
ajst-32482	102	14	to	to	PART
ajst-32482	102	15	release	release	VERB
ajst-32482	102	16	tumor	tumor	NOUN
ajst-32482	102	17	antigens	antigen	NOUN
ajst-32482	102	18	,	,	PUNCT
ajst-32482	102	19	thereby	thereby	ADV
ajst-32482	102	20	strengthening	strengthen	VERB
ajst-32482	102	21	the	the	DET
ajst-32482	102	22	immune	immune	ADJ
ajst-32482	102	23	response	response	NOUN
ajst-32482	102	24	.	.	PUNCT
ajst-32482	103	1	combining	combine	VERB
ajst-32482	103	2	them	they	PRON
ajst-32482	103	3	with	with	ADP
ajst-32482	103	4	newer	new	ADJ
ajst-32482	103	5	immunotherapies	immunotherapy	NOUN
ajst-32482	103	6	,	,	PUNCT
ajst-32482	103	7	such	such	ADJ
ajst-32482	103	8	as	as	ADP
ajst-32482	103	9	car	car	NOUN
ajst-32482	103	10	-	-	PUNCT
ajst-32482	103	11	t	t	NOUN
ajst-32482	103	12	cell	cell	NOUN
ajst-32482	103	13	therapy	therapy	NOUN
ajst-32482	103	14	or	or	CCONJ
ajst-32482	103	15	tumor	tumor	NOUN
ajst-32482	103	16	vaccines	vaccine	NOUN
ajst-32482	103	17	,	,	PUNCT
ajst-32482	103	18	might	might	AUX
ajst-32482	103	19	break	break	VERB
ajst-32482	103	20	the	the	DET
ajst-32482	103	21	"	"	PUNCT
ajst-32482	103	22	immune	immune	ADJ
ajst-32482	103	23	-	-	PUNCT
ajst-32482	103	24	suppressive	suppressive	NOUN
ajst-32482	103	25	wall	wall	NOUN
ajst-32482	103	26	"	"	PUNCT
ajst-32482	103	27	surrounding	surround	VERB
ajst-32482	103	28	the	the	DET
ajst-32482	103	29	tumor	tumor	NOUN
ajst-32482	103	30	.	.	PUNCT
ajst-32482	104	1	5.2	5.2	NUM
ajst-32482	104	2	exploration	exploration	NOUN
ajst-32482	104	3	of	of	ADP
ajst-32482	104	4	new	new	ADJ
ajst-32482	104	5	targets	target	NOUN
ajst-32482	104	6	most	most	ADJ
ajst-32482	104	7	inhibitors	inhibitor	NOUN
ajst-32482	104	8	focus	focus	VERB
ajst-32482	104	9	on	on	ADP
ajst-32482	104	10	pd-1	pd-1	ADP
ajst-32482	104	11	/	/	SYM
ajst-32482	104	12	pd	pd	NOUN
ajst-32482	104	13	-	-	PROPN
ajst-32482	104	14	l1	l1	PROPN
ajst-32482	104	15	and	and	CCONJ
ajst-32482	104	16	ctla-4	ctla-4	NUM
ajst-32482	104	17	,	,	PUNCT
ajst-32482	104	18	but	but	CCONJ
ajst-32482	104	19	these	these	PRON
ajst-32482	104	20	are	be	AUX
ajst-32482	104	21	n’t	not	PART
ajst-32482	104	22	the	the	DET
ajst-32482	104	23	only	only	ADJ
ajst-32482	104	24	immune	immune	ADJ
ajst-32482	104	25	checkpoints	checkpoint	NOUN
ajst-32482	104	26	.	.	PUNCT
ajst-32482	105	1	molecules	molecule	NOUN
ajst-32482	105	2	such	such	ADJ
ajst-32482	105	3	as	as	ADP
ajst-32482	105	4	lag-3	lag-3	NUM
ajst-32482	105	5	,	,	PUNCT
ajst-32482	105	6	tim-3	tim-3	ADV
ajst-32482	105	7	,	,	PUNCT
ajst-32482	105	8	and	and	CCONJ
ajst-32482	105	9	tigit	tigit	NOUN
ajst-32482	105	10	are	be	AUX
ajst-32482	105	11	now	now	ADV
ajst-32482	105	12	being	be	AUX
ajst-32482	105	13	closely	closely	ADV
ajst-32482	105	14	studied	study	VERB
ajst-32482	105	15	.	.	PUNCT
ajst-32482	106	1	a	a	DET
ajst-32482	106	2	2024	2024	NUM
ajst-32482	106	3	review	review	NOUN
ajst-32482	106	4	in	in	ADP
ajst-32482	106	5	cancer	cancer	NOUN
ajst-32482	106	6	biology	biology	NOUN
ajst-32482	106	7	&	&	CCONJ
ajst-32482	106	8	medicine	medicine	NOUN
ajst-32482	106	9	by	by	ADP
ajst-32482	106	10	researchers	researcher	NOUN
ajst-32482	106	11	from	from	ADP
ajst-32482	106	12	guangdong	guangdong	PROPN
ajst-32482	106	13	pharmaceutical	pharmaceutical	PROPN
ajst-32482	106	14	university	university	NOUN
ajst-32482	106	15	highlighted	highlight	VERB
ajst-32482	106	16	that	that	SCONJ
ajst-32482	106	17	these	these	DET
ajst-32482	106	18	new	new	ADJ
ajst-32482	106	19	targets	target	NOUN
ajst-32482	106	20	could	could	AUX
ajst-32482	106	21	help	help	VERB
ajst-32482	106	22	address	address	VERB
ajst-32482	106	23	the	the	DET
ajst-32482	106	24	issue	issue	NOUN
ajst-32482	106	25	of	of	ADP
ajst-32482	106	26	resistance	resistance	NOUN
ajst-32482	106	27	to	to	ADP
ajst-32482	106	28	current	current	ADJ
ajst-32482	106	29	pd-1	pd-1	NOUN
ajst-32482	106	30	/	/	SYM
ajst-32482	106	31	ctla-4	ctla-4	NOUN
ajst-32482	106	32	inhibitors	inhibitor	NOUN
ajst-32482	106	33	.	.	PUNCT
ajst-32482	107	1	for	for	ADP
ajst-32482	107	2	example	example	NOUN
ajst-32482	107	3	,	,	PUNCT
ajst-32482	107	4	monoclonal	monoclonal	NOUN
ajst-32482	107	5	antibodies	antibody	NOUN
ajst-32482	107	6	targeting	target	VERB
ajst-32482	107	7	lag-3	lag-3	X
ajst-32482	107	8	are	be	AUX
ajst-32482	107	9	already	already	ADV
ajst-32482	107	10	in	in	ADP
ajst-32482	107	11	early	early	ADJ
ajst-32482	107	12	development	development	NOUN
ajst-32482	107	13	,	,	PUNCT
ajst-32482	107	14	and	and	CCONJ
ajst-32482	107	15	they	they	PRON
ajst-32482	107	16	might	might	AUX
ajst-32482	107	17	work	work	VERB
ajst-32482	107	18	better	well	ADV
ajst-32482	107	19	for	for	ADP
ajst-32482	107	20	patients	patient	NOUN
ajst-32482	107	21	who	who	PRON
ajst-32482	107	22	do	do	AUX
ajst-32482	107	23	n’t	not	PART
ajst-32482	107	24	respond	respond	VERB
ajst-32482	107	25	to	to	ADP
ajst-32482	107	26	existing	exist	VERB
ajst-32482	107	27	drugs	drug	NOUN
ajst-32482	107	28	.	.	PUNCT
ajst-32482	108	1	6	6	X
ajst-32482	108	2	.	.	X
ajst-32482	108	3	conclusion	conclusion	NOUN
ajst-32482	108	4	immune	immune	ADJ
ajst-32482	108	5	checkpoint	checkpoint	NOUN
ajst-32482	108	6	inhibitors	inhibitor	NOUN
ajst-32482	108	7	have	have	AUX
ajst-32482	108	8	significantly	significantly	ADV
ajst-32482	108	9	changed	change	VERB
ajst-32482	108	10	cancer	cancer	NOUN
ajst-32482	108	11	treatment	treatment	NOUN
ajst-32482	108	12	.	.	PUNCT
ajst-32482	109	1	studies	study	NOUN
ajst-32482	109	2	from	from	ADP
ajst-32482	109	3	the	the	DET
ajst-32482	109	4	2024	2024	NUM
ajst-32482	109	5	esmo	esmo	NOUN
ajst-32482	109	6	congress	congress	NOUN
ajst-32482	109	7	,	,	PUNCT
ajst-32482	109	8	along	along	ADP
ajst-32482	109	9	with	with	ADP
ajst-32482	109	10	tools	tool	NOUN
ajst-32482	109	11	like	like	ADP
ajst-32482	109	12	the	the	DET
ajst-32482	109	13	scorpio	scorpio	PROPN
ajst-32482	109	14	model	model	NOUN
ajst-32482	109	15	,	,	PUNCT
ajst-32482	109	16	demonstrate	demonstrate	VERB
ajst-32482	109	17	their	their	PRON
ajst-32482	109	18	effectiveness	effectiveness	NOUN
ajst-32482	109	19	.	.	PUNCT
ajst-32482	110	1	however	however	ADV
ajst-32482	110	2	,	,	PUNCT
ajst-32482	110	3	challenges	challenge	NOUN
ajst-32482	110	4	remain	remain	VERB
ajst-32482	110	5	:	:	PUNCT
ajst-32482	110	6	finding	find	VERB
ajst-32482	110	7	the	the	DET
ajst-32482	110	8	optimal	optimal	ADJ
ajst-32482	110	9	mix	mix	NOUN
ajst-32482	110	10	in	in	ADP
ajst-32482	110	11	combined	combined	ADJ
ajst-32482	110	12	therapies	therapy	NOUN
ajst-32482	110	13	,	,	PUNCT
ajst-32482	110	14	maximizing	maximize	VERB
ajst-32482	110	15	the	the	DET
ajst-32482	110	16	benefits	benefit	NOUN
ajst-32482	110	17	of	of	ADP
ajst-32482	110	18	new	new	ADJ
ajst-32482	110	19	targets	target	NOUN
ajst-32482	110	20	such	such	ADJ
ajst-32482	110	21	as	as	ADP
ajst-32482	110	22	lag—3	lag—3	NOUN
ajst-32482	110	23	,	,	PUNCT
ajst-32482	110	24	and	and	CCONJ
ajst-32482	110	25	improving	improve	VERB
ajst-32482	110	26	personalized	personalized	ADJ
ajst-32482	110	27	predictions	prediction	NOUN
ajst-32482	110	28	.	.	PUNCT
ajst-32482	111	1	as	as	SCONJ
ajst-32482	111	2	research	research	NOUN
ajst-32482	111	3	progresses	progress	NOUN
ajst-32482	111	4	,	,	PUNCT
ajst-32482	111	5	soon	soon	ADV
ajst-32482	111	6	,	,	PUNCT
ajst-32482	111	7	immune	immune	ADJ
ajst-32482	111	8	checkpoint	checkpoint	NOUN
ajst-32482	111	9	inhibitors	inhibitor	NOUN
ajst-32482	111	10	will	will	AUX
ajst-32482	111	11	become	become	VERB
ajst-32482	111	12	more	more	ADV
ajst-32482	111	13	precise	precise	ADJ
ajst-32482	111	14	and	and	CCONJ
ajst-32482	111	15	safer	safe	ADJ
ajst-32482	111	16	ways	way	NOUN
ajst-32482	111	17	to	to	PART
ajst-32482	111	18	fight	fight	VERB
ajst-32482	111	19	cancer	cancer	NOUN
ajst-32482	111	20	.	.	PUNCT
ajst-32482	112	1	they	they	PRON
ajst-32482	112	2	’ll	’ll	AUX
ajst-32482	112	3	reshape	reshape	VERB
ajst-32482	112	4	how	how	SCONJ
ajst-32482	112	5	we	we	PRON
ajst-32482	112	6	treat	treat	VERB
ajst-32482	112	7	cancer	cancer	NOUN
ajst-32482	112	8	and	and	CCONJ
ajst-32482	112	9	bring	bring	VERB
ajst-32482	112	10	new	new	ADJ
ajst-32482	112	11	hope	hope	NOUN
ajst-32482	112	12	to	to	ADP
ajst-32482	112	13	patients	patient	NOUN
ajst-32482	112	14	worldwide	worldwide	ADV
ajst-32482	112	15	.	.	PUNCT
ajst-32482	113	1	references	reference	NOUN
ajst-32482	113	2	[	[	X
ajst-32482	113	3	1	1	NUM
ajst-32482	113	4	]	]	X
ajst-32482	113	5	dutta	dutta	PROPN
ajst-32482	113	6	,	,	PUNCT
ajst-32482	113	7	s.	s.	PROPN
ajst-32482	113	8	,	,	PUNCT
ajst-32482	113	9	ganguly	ganguly	PROPN
ajst-32482	113	10	,	,	PUNCT
ajst-32482	113	11	a.	a.	NOUN
ajst-32482	113	12	,	,	PUNCT
ajst-32482	113	13	chatterjee	chatterjee	PROPN
ajst-32482	113	14	,	,	PUNCT
ajst-32482	113	15	k.	k.	PROPN
ajst-32482	113	16	,	,	PUNCT
ajst-32482	113	17	spada	spada	PROPN
ajst-32482	113	18	,	,	PUNCT
ajst-32482	113	19	s.	s.	PROPN
ajst-32482	113	20	,	,	PUNCT
ajst-32482	113	21	&	&	CCONJ
ajst-32482	113	22	mukherjee	mukherjee	PROPN
ajst-32482	113	23	,	,	PUNCT
ajst-32482	113	24	s.	s.	PROPN
ajst-32482	113	25	(	(	PUNCT
ajst-32482	113	26	2023	2023	NUM
ajst-32482	113	27	)	)	PUNCT
ajst-32482	113	28	.	.	PUNCT
ajst-32482	114	1	targets	target	NOUN
ajst-32482	114	2	of	of	ADP
ajst-32482	114	3	immune	immune	ADJ
ajst-32482	114	4	escape	escape	NOUN
ajst-32482	114	5	mechanisms	mechanism	NOUN
ajst-32482	114	6	in	in	ADP
ajst-32482	114	7	cancer	cancer	NOUN
ajst-32482	114	8	:	:	PUNCT
ajst-32482	114	9	basis	basis	NOUN
ajst-32482	114	10	for	for	ADP
ajst-32482	114	11	development	development	NOUN
ajst-32482	114	12	and	and	CCONJ
ajst-32482	114	13	evolution	evolution	NOUN
ajst-32482	114	14	of	of	ADP
ajst-32482	114	15	cancer	cancer	NOUN
ajst-32482	114	16	immune	immune	ADJ
ajst-32482	114	17	checkpoint	checkpoint	NOUN
ajst-32482	114	18	inhibitors	inhibitor	NOUN
ajst-32482	114	19	.	.	PUNCT
ajst-32482	115	1	biology	biology	NOUN
ajst-32482	115	2	,	,	PUNCT
ajst-32482	115	3	12(2	12(2	NUM
ajst-32482	115	4	)	)	PUNCT
ajst-32482	115	5	,	,	PUNCT
ajst-32482	115	6	218	218	NUM
ajst-32482	115	7	.	.	PUNCT
ajst-32482	116	1	[	[	X
ajst-32482	116	2	2	2	NUM
ajst-32482	116	3	]	]	PUNCT
ajst-32482	116	4	bagchi	bagchi	NOUN
ajst-32482	116	5	,	,	PUNCT
ajst-32482	116	6	s.	s.	PROPN
ajst-32482	116	7	,	,	PUNCT
ajst-32482	116	8	yuan	yuan	PROPN
ajst-32482	116	9	,	,	PUNCT
ajst-32482	116	10	r.	r.	PROPN
ajst-32482	116	11	,	,	PUNCT
ajst-32482	116	12	&	&	CCONJ
ajst-32482	116	13	engleman	engleman	PROPN
ajst-32482	116	14	,	,	PUNCT
ajst-32482	116	15	e.	e.	PROPN
ajst-32482	116	16	g.	g.	PROPN
ajst-32482	116	17	(	(	PUNCT
ajst-32482	116	18	2021	2021	NUM
ajst-32482	116	19	)	)	PUNCT
ajst-32482	116	20	.	.	PUNCT
ajst-32482	117	1	immune	immune	ADJ
ajst-32482	117	2	checkpoint	checkpoint	NOUN
ajst-32482	117	3	inhibitors	inhibitor	NOUN
ajst-32482	117	4	for	for	ADP
ajst-32482	117	5	the	the	DET
ajst-32482	117	6	treatment	treatment	NOUN
ajst-32482	117	7	of	of	ADP
ajst-32482	117	8	cancer	cancer	NOUN
ajst-32482	117	9	:	:	PUNCT
ajst-32482	117	10	clinical	clinical	ADJ
ajst-32482	117	11	impact	impact	NOUN
ajst-32482	117	12	and	and	CCONJ
ajst-32482	117	13	mechanisms	mechanism	NOUN
ajst-32482	117	14	of	of	ADP
ajst-32482	117	15	response	response	NOUN
ajst-32482	117	16	and	and	CCONJ
ajst-32482	117	17	resistance	resistance	NOUN
ajst-32482	117	18	.	.	PUNCT
ajst-32482	118	1	annual	annual	ADJ
ajst-32482	118	2	review	review	NOUN
ajst-32482	118	3	of	of	ADP
ajst-32482	118	4	pathology	pathology	NOUN
ajst-32482	118	5	:	:	PUNCT
ajst-32482	118	6	mechanisms	mechanism	NOUN
ajst-32482	118	7	of	of	ADP
ajst-32482	118	8	disease	disease	NOUN
ajst-32482	118	9	,	,	PUNCT
ajst-32482	118	10	16(1	16(1	NUM
ajst-32482	118	11	)	)	PUNCT
ajst-32482	118	12	,	,	PUNCT
ajst-32482	118	13	223	223	NUM
ajst-32482	118	14	-	-	SYM
ajst-32482	118	15	249	249	NUM
ajst-32482	118	16	.	.	PUNCT
ajst-32482	119	1	110	110	NUM
ajst-32482	120	1	[	[	X
ajst-32482	120	2	3	3	NUM
ajst-32482	120	3	]	]	X
ajst-32482	120	4	o'garra	o'garra	PROPN
ajst-32482	120	5	,	,	PUNCT
ajst-32482	120	6	a.	a.	PROPN
ajst-32482	120	7	,	,	PUNCT
ajst-32482	120	8	vieira	vieira	PROPN
ajst-32482	120	9	,	,	PUNCT
ajst-32482	120	10	p.	p.	PROPN
ajst-32482	120	11	regulatory	regulatory	ADJ
ajst-32482	120	12	t	t	PROPN
ajst-32482	120	13	cells	cell	NOUN
ajst-32482	120	14	and	and	CCONJ
ajst-32482	120	15	mechanisms	mechanism	NOUN
ajst-32482	120	16	of	of	ADP
ajst-32482	120	17	immune	immune	ADJ
ajst-32482	120	18	system	system	NOUN
ajst-32482	120	19	control	control	NOUN
ajst-32482	120	20	.	.	PUNCT
ajst-32482	121	1	nat	nat	PROPN
ajst-32482	121	2	med	me	VERB
ajst-32482	121	3	10	10	NUM
ajst-32482	121	4	,	,	PUNCT
ajst-32482	121	5	801	801	NUM
ajst-32482	121	6	–	–	PUNCT
ajst-32482	121	7	805	805	NUM
ajst-32482	121	8	(	(	PUNCT
ajst-32482	121	9	2004	2004	NUM
ajst-32482	121	10	)	)	PUNCT
ajst-32482	121	11	.	.	PUNCT
ajst-32482	122	1	https://doi.org/10.1038/nm0804-801	https://doi.org/10.1038/nm0804-801	X
ajst-32482	122	2	.	.	PUNCT
ajst-32482	123	1	[	[	X
ajst-32482	123	2	4	4	NUM
ajst-32482	123	3	]	]	X
ajst-32482	123	4	naimi	naimi	NOUN
ajst-32482	123	5	a	a	PROPN
ajst-32482	123	6	,	,	PUNCT
ajst-32482	123	7	mohammed	mohammed	PROPN
ajst-32482	123	8	rn	rn	PROPN
ajst-32482	123	9	,	,	PUNCT
ajst-32482	123	10	raji	raji	PROPN
ajst-32482	123	11	a	a	PRON
ajst-32482	123	12	,	,	PUNCT
ajst-32482	123	13	chupradit	chupradit	NOUN
ajst-32482	123	14	s	s	PROPN
ajst-32482	123	15	,	,	PUNCT
ajst-32482	123	16	yumashev	yumashev	PROPN
ajst-32482	123	17	av	av	PROPN
ajst-32482	123	18	,	,	PUNCT
ajst-32482	123	19	suksatan	suksatan	PROPN
ajst-32482	123	20	w	w	PROPN
ajst-32482	123	21	,	,	PUNCT
ajst-32482	123	22	shalaby	shalaby	PROPN
ajst-32482	123	23	mn	mn	PROPN
ajst-32482	123	24	,	,	PUNCT
ajst-32482	123	25	thangavelu	thangavelu	NOUN
ajst-32482	123	26	l	l	NOUN
ajst-32482	123	27	,	,	PUNCT
ajst-32482	123	28	kamrava	kamrava	NOUN
ajst-32482	123	29	s	s	PROPN
ajst-32482	123	30	,	,	PUNCT
ajst-32482	123	31	shomali	shomali	VERB
ajst-32482	123	32	n	n	PRON
ajst-32482	123	33	,	,	PUNCT
ajst-32482	123	34	sohrabi	sohrabi	NOUN
ajst-32482	123	35	ad	ad	NOUN
ajst-32482	123	36	,	,	PUNCT
ajst-32482	123	37	adili	adili	ADP
ajst-32482	123	38	a	a	DET
ajst-32482	123	39	,	,	PUNCT
ajst-32482	123	40	noroozi	noroozi	NOUN
ajst-32482	123	41	-	-	PUNCT
ajst-32482	123	42	aghideh	aghideh	PROPN
ajst-32482	123	43	a	a	PRON
ajst-32482	123	44	,	,	PUNCT
ajst-32482	123	45	razeghian	razeghian	PROPN
ajst-32482	123	46	e.	e.	PROPN
ajst-32482	123	47	tumor	tumor	PROPN
ajst-32482	123	48	immunotherapies	immunotherapy	NOUN
ajst-32482	123	49	by	by	ADP
ajst-32482	123	50	immune	immune	ADJ
ajst-32482	123	51	checkpoint	checkpoint	NOUN
ajst-32482	123	52	inhibitors	inhibitor	NOUN
ajst-32482	123	53	(	(	PUNCT
ajst-32482	123	54	icis	icis	PROPN
ajst-32482	123	55	)	)	PUNCT
ajst-32482	123	56	;	;	PUNCT
ajst-32482	123	57	the	the	DET
ajst-32482	123	58	pros	pro	NOUN
ajst-32482	123	59	and	and	CCONJ
ajst-32482	123	60	cons	con	NOUN
ajst-32482	123	61	.	.	PUNCT
ajst-32482	124	1	cell	cell	NOUN
ajst-32482	124	2	commun	commun	PROPN
ajst-32482	124	3	signal	signal	PROPN
ajst-32482	124	4	.	.	PUNCT
ajst-32482	125	1	2022	2022	NUM
ajst-32482	125	2	apr	apr	NOUN
ajst-32482	125	3	7;20(1):44	7;20(1):44	NOUN
ajst-32482	125	4	.	.	PUNCT
ajst-32482	126	1	doi	doi	NOUN
ajst-32482	126	2	:	:	PUNCT
ajst-32482	126	3	10.1186	10.1186	NUM
ajst-32482	126	4	/	/	SYM
ajst-32482	126	5	s12964	s12964	PROPN
ajst-32482	126	6	-	-	PUNCT
ajst-32482	126	7	022	022	NUM
ajst-32482	126	8	-	-	PUNCT
ajst-32482	126	9	00854	00854	NUM
ajst-32482	126	10	-	-	PUNCT
ajst-32482	126	11	y.	y.	NOUN
ajst-32482	126	12	pmid	pmid	PROPN
ajst-32482	126	13	:	:	PUNCT
ajst-32482	126	14	35392976	35392976	NUM
ajst-32482	126	15	;	;	PUNCT
ajst-32482	126	16	pmcid	pmcid	ADJ
ajst-32482	126	17	:	:	PUNCT
ajst-32482	126	18	pmc8991803	pmc8991803	NOUN
ajst-32482	126	19	.	.	PUNCT
ajst-32482	127	1	[	[	X
ajst-32482	127	2	5	5	NUM
ajst-32482	127	3	]	]	SYM
ajst-32482	127	4	wu	wu	PROPN
ajst-32482	127	5	,	,	PUNCT
ajst-32482	127	6	q.	q.	PROPN
ajst-32482	127	7	,	,	PUNCT
ajst-32482	127	8	qian	qian	PROPN
ajst-32482	127	9	,	,	PUNCT
ajst-32482	127	10	w.	w.	PROPN
ajst-32482	127	11	,	,	PUNCT
ajst-32482	127	12	sun	sun	PROPN
ajst-32482	127	13	,	,	PUNCT
ajst-32482	127	14	x.	x.	NOUN
ajst-32482	127	15	et	et	PROPN
ajst-32482	127	16	al	al	PROPN
ajst-32482	127	17	.	.	PUNCT
ajst-32482	127	18	small	small	ADJ
ajst-32482	127	19	-	-	PUNCT
ajst-32482	127	20	molecule	molecule	NOUN
ajst-32482	127	21	inhibitors	inhibitor	NOUN
ajst-32482	127	22	,	,	PUNCT
ajst-32482	127	23	immune	immune	ADJ
ajst-32482	127	24	checkpoint	checkpoint	NOUN
ajst-32482	127	25	inhibitors	inhibitor	NOUN
ajst-32482	127	26	,	,	PUNCT
ajst-32482	127	27	and	and	CCONJ
ajst-32482	127	28	more	more	ADV
ajst-32482	127	29	:	:	PUNCT
ajst-32482	127	30	fda	fda	PROPN
ajst-32482	127	31	-	-	PUNCT
ajst-32482	127	32	approved	approve	VERB
ajst-32482	127	33	novel	novel	ADJ
ajst-32482	127	34	therapeutic	therapeutic	ADJ
ajst-32482	127	35	drugs	drug	NOUN
ajst-32482	127	36	for	for	ADP
ajst-32482	127	37	solid	solid	ADJ
ajst-32482	127	38	tumors	tumor	NOUN
ajst-32482	127	39	from	from	ADP
ajst-32482	127	40	1991	1991	NUM
ajst-32482	127	41	to	to	ADP
ajst-32482	127	42	2021	2021	NUM
ajst-32482	127	43	.	.	PUNCT
ajst-32482	128	1	j	j	PROPN
ajst-32482	128	2	hematol	hematol	PROPN
ajst-32482	128	3	oncol	oncol	ADJ
ajst-32482	128	4	15	15	NUM
ajst-32482	128	5	,	,	PUNCT
ajst-32482	128	6	143	143	NUM
ajst-32482	128	7	(	(	PUNCT
ajst-32482	128	8	2022	2022	NUM
ajst-32482	128	9	)	)	PUNCT
ajst-32482	128	10	.	.	PUNCT
ajst-32482	129	1	[	[	X
ajst-32482	129	2	6	6	NUM
ajst-32482	129	3	]	]	X
ajst-32482	129	4	hossain	hossain	PROPN
ajst-32482	129	5	,	,	PUNCT
ajst-32482	129	6	m.	m.	NOUN
ajst-32482	129	7	a.	a.	NOUN
ajst-32482	129	8	(	(	PUNCT
ajst-32482	129	9	2024	2024	NUM
ajst-32482	129	10	)	)	PUNCT
ajst-32482	129	11	.	.	PUNCT
ajst-32482	130	1	a	a	DET
ajst-32482	130	2	comprehensive	comprehensive	ADJ
ajst-32482	130	3	review	review	NOUN
ajst-32482	130	4	of	of	ADP
ajst-32482	130	5	immune	immune	ADJ
ajst-32482	130	6	checkpoint	checkpoint	NOUN
ajst-32482	130	7	inhibitors	inhibitor	NOUN
ajst-32482	130	8	for	for	ADP
ajst-32482	130	9	cancer	cancer	NOUN
ajst-32482	130	10	treatment	treatment	NOUN
ajst-32482	130	11	.	.	PUNCT
ajst-32482	131	1	international	international	ADJ
ajst-32482	131	2	immunopharmacology	immunopharmacology	PROPN
ajst-32482	131	3	,	,	PUNCT
ajst-32482	131	4	143	143	NUM
ajst-32482	131	5	,	,	PUNCT
ajst-32482	131	6	113365	113365	NUM
ajst-32482	131	7	.	.	PUNCT