id	sid	tid	token	lemma	pos
ajst-32496	1	1	136	136	NUM
ajst-32496	1	2	the	the	DET
ajst-32496	1	3	research	research	NOUN
ajst-32496	1	4	on	on	ADP
ajst-32496	1	5	the	the	DET
ajst-32496	1	6	synthesis	synthesis	NOUN
ajst-32496	1	7	method	method	NOUN
ajst-32496	1	8	of	of	ADP
ajst-32496	1	9	sulphonamide	sulphonamide	NOUN
ajst-32496	1	10	and	and	CCONJ
ajst-32496	1	11	the	the	DET
ajst-32496	1	12	scheme	scheme	NOUN
ajst-32496	1	13	for	for	ADP
ajst-32496	1	14	improving	improve	VERB
ajst-32496	1	15	the	the	DET
ajst-32496	1	16	synthesis	synthesis	NOUN
ajst-32496	1	17	technology	technology	NOUN
ajst-32496	1	18	tongying	tongying	NOUN
ajst-32496	1	19	liu	liu	PROPN
ajst-32496	1	20	1	1	PROPN
ajst-32496	1	21	,	,	PUNCT
ajst-32496	1	22	a	a	DET
ajst-32496	1	23	,	,	PUNCT
ajst-32496	1	24	mahanqi	mahanqi	NOUN
ajst-32496	1	25	mao	mao	NOUN
ajst-32496	1	26	2	2	NUM
ajst-32496	1	27	,	,	PUNCT
ajst-32496	1	28	b	b	PROPN
ajst-32496	1	29	1	1	NUM
ajst-32496	1	30	shenzhen	shenzhen	PROPN
ajst-32496	1	31	senior	senior	ADJ
ajst-32496	1	32	high	high	ADJ
ajst-32496	1	33	school	school	NOUN
ajst-32496	1	34	,	,	PUNCT
ajst-32496	1	35	shenzhen	shenzhen	PROPN
ajst-32496	1	36	,	,	PUNCT
ajst-32496	1	37	guangdong	guangdong	PROPN
ajst-32496	1	38	,	,	PUNCT
ajst-32496	1	39	china	china	PROPN
ajst-32496	1	40	2	2	NUM
ajst-32496	1	41	beijing	beijing	PROPN
ajst-32496	1	42	new	new	ADJ
ajst-32496	1	43	oriental	oriental	ADJ
ajst-32496	1	44	foreign	foreign	ADJ
ajst-32496	1	45	language	language	NOUN
ajst-32496	1	46	school	school	NOUN
ajst-32496	1	47	at	at	ADP
ajst-32496	1	48	yangzhou	yangzhou	PROPN
ajst-32496	1	49	,	,	PUNCT
ajst-32496	1	50	yangzhou	yangzhou	PROPN
ajst-32496	1	51	,	,	PUNCT
ajst-32496	1	52	jiangsu	jiangsu	PROPN
ajst-32496	1	53	,	,	PUNCT
ajst-32496	1	54	china	china	PROPN
ajst-32496	1	55	a	a	DET
ajst-32496	1	56	3408864672@qq.com	3408864672@qq.com	NUM
ajst-32496	1	57	,	,	PUNCT
ajst-32496	1	58	b	b	PROPN
ajst-32496	1	59	mm2513@qq.com	mm2513@qq.com	X
ajst-32496	1	60	abstract	abstract	NOUN
ajst-32496	1	61	.	.	PUNCT
ajst-32496	2	1	sulphonamides	sulphonamide	NOUN
ajst-32496	2	2	,	,	PUNCT
ajst-32496	2	3	as	as	ADP
ajst-32496	2	4	one	one	NUM
ajst-32496	2	5	of	of	ADP
ajst-32496	2	6	the	the	DET
ajst-32496	2	7	earliest	early	ADJ
ajst-32496	2	8	classes	class	NOUN
ajst-32496	2	9	of	of	ADP
ajst-32496	2	10	synthetic	synthetic	ADJ
ajst-32496	2	11	antibacterial	antibacterial	ADJ
ajst-32496	2	12	agents	agent	NOUN
ajst-32496	2	13	,	,	PUNCT
ajst-32496	2	14	remain	remain	VERB
ajst-32496	2	15	essential	essential	ADJ
ajst-32496	2	16	in	in	ADP
ajst-32496	2	17	pharmaceutical	pharmaceutical	ADJ
ajst-32496	2	18	and	and	CCONJ
ajst-32496	2	19	chemical	chemical	NOUN
ajst-32496	2	20	industries	industry	NOUN
ajst-32496	2	21	due	due	ADP
ajst-32496	2	22	to	to	ADP
ajst-32496	2	23	their	their	PRON
ajst-32496	2	24	broad	broad	ADJ
ajst-32496	2	25	-	-	PUNCT
ajst-32496	2	26	spectrum	spectrum	NOUN
ajst-32496	2	27	activity	activity	NOUN
ajst-32496	2	28	and	and	CCONJ
ajst-32496	2	29	versatile	versatile	ADJ
ajst-32496	2	30	applications	application	NOUN
ajst-32496	2	31	.	.	PUNCT
ajst-32496	3	1	this	this	DET
ajst-32496	3	2	study	study	NOUN
ajst-32496	3	3	reviews	review	VERB
ajst-32496	3	4	the	the	DET
ajst-32496	3	5	classical	classical	ADJ
ajst-32496	3	6	multi	multi	ADJ
ajst-32496	3	7	-	-	ADJ
ajst-32496	3	8	step	step	ADJ
ajst-32496	3	9	synthesis	synthesis	NOUN
ajst-32496	3	10	of	of	ADP
ajst-32496	3	11	sulphanilamide	sulphanilamide	NOUN
ajst-32496	3	12	,	,	PUNCT
ajst-32496	3	13	analyzing	analyze	VERB
ajst-32496	3	14	its	its	PRON
ajst-32496	3	15	reaction	reaction	NOUN
ajst-32496	3	16	mechanisms	mechanism	NOUN
ajst-32496	3	17	,	,	PUNCT
ajst-32496	3	18	operational	operational	ADJ
ajst-32496	3	19	limitations	limitation	NOUN
ajst-32496	3	20	,	,	PUNCT
ajst-32496	3	21	and	and	CCONJ
ajst-32496	3	22	environmental	environmental	ADJ
ajst-32496	3	23	challenges	challenge	NOUN
ajst-32496	3	24	,	,	PUNCT
ajst-32496	3	25	including	include	VERB
ajst-32496	3	26	high	high	ADJ
ajst-32496	3	27	energy	energy	NOUN
ajst-32496	3	28	consumption	consumption	NOUN
ajst-32496	3	29	,	,	PUNCT
ajst-32496	3	30	low	low	ADJ
ajst-32496	3	31	yield	yield	NOUN
ajst-32496	3	32	,	,	PUNCT
ajst-32496	3	33	and	and	CCONJ
ajst-32496	3	34	the	the	DET
ajst-32496	3	35	formation	formation	NOUN
ajst-32496	3	36	of	of	ADP
ajst-32496	3	37	toxic	toxic	ADJ
ajst-32496	3	38	by	by	ADP
ajst-32496	3	39	-	-	PUNCT
ajst-32496	3	40	products	product	NOUN
ajst-32496	3	41	.	.	PUNCT
ajst-32496	4	1	through	through	ADP
ajst-32496	4	2	laboratory	laboratory	NOUN
ajst-32496	4	3	validation	validation	NOUN
ajst-32496	4	4	,	,	PUNCT
ajst-32496	4	5	the	the	DET
ajst-32496	4	6	traditional	traditional	ADJ
ajst-32496	4	7	route	route	NOUN
ajst-32496	4	8	was	be	AUX
ajst-32496	4	9	confirmed	confirm	VERB
ajst-32496	4	10	to	to	PART
ajst-32496	4	11	be	be	AUX
ajst-32496	4	12	feasible	feasible	ADJ
ajst-32496	4	13	but	but	CCONJ
ajst-32496	4	14	inefficient	inefficient	ADJ
ajst-32496	4	15	,	,	PUNCT
ajst-32496	4	16	motivating	motivate	VERB
ajst-32496	4	17	the	the	DET
ajst-32496	4	18	exploration	exploration	NOUN
ajst-32496	4	19	of	of	ADP
ajst-32496	4	20	innovative	innovative	ADJ
ajst-32496	4	21	synthesis	synthesis	NOUN
ajst-32496	4	22	technologies	technology	NOUN
ajst-32496	4	23	.	.	PUNCT
ajst-32496	5	1	based	base	VERB
ajst-32496	5	2	on	on	ADP
ajst-32496	5	3	a	a	DET
ajst-32496	5	4	comparative	comparative	ADJ
ajst-32496	5	5	literature	literature	NOUN
ajst-32496	5	6	review	review	NOUN
ajst-32496	5	7	,	,	PUNCT
ajst-32496	5	8	this	this	DET
ajst-32496	5	9	paper	paper	NOUN
ajst-32496	5	10	examines	examine	VERB
ajst-32496	5	11	three	three	NUM
ajst-32496	5	12	contemporary	contemporary	ADJ
ajst-32496	5	13	optimization	optimization	NOUN
ajst-32496	5	14	strategies	strategy	NOUN
ajst-32496	5	15	:	:	PUNCT
ajst-32496	5	16	continuous	continuous	ADJ
ajst-32496	5	17	flow	flow	NOUN
ajst-32496	5	18	technology	technology	NOUN
ajst-32496	5	19	(	(	PUNCT
ajst-32496	5	20	cft	cft	PROPN
ajst-32496	5	21	)	)	PUNCT
ajst-32496	5	22	,	,	PUNCT
ajst-32496	5	23	green	green	ADJ
ajst-32496	5	24	chemistry	chemistry	NOUN
ajst-32496	5	25	(	(	PUNCT
ajst-32496	5	26	gc	gc	PROPN
ajst-32496	5	27	)	)	PUNCT
ajst-32496	5	28	,	,	PUNCT
ajst-32496	5	29	and	and	CCONJ
ajst-32496	5	30	electrochemical	electrochemical	ADJ
ajst-32496	5	31	synthesis	synthesis	NOUN
ajst-32496	5	32	(	(	PUNCT
ajst-32496	5	33	ecs	ec	NOUN
ajst-32496	5	34	)	)	PUNCT
ajst-32496	5	35	.	.	PUNCT
ajst-32496	6	1	continuous	continuous	ADJ
ajst-32496	6	2	flow	flow	NOUN
ajst-32496	6	3	technology	technology	NOUN
ajst-32496	6	4	improves	improve	VERB
ajst-32496	6	5	reaction	reaction	NOUN
ajst-32496	6	6	control	control	NOUN
ajst-32496	6	7	,	,	PUNCT
ajst-32496	6	8	safety	safety	NOUN
ajst-32496	6	9	,	,	PUNCT
ajst-32496	6	10	and	and	CCONJ
ajst-32496	6	11	scalability	scalability	NOUN
ajst-32496	6	12	;	;	PUNCT
ajst-32496	6	13	green	green	ADJ
ajst-32496	6	14	chemistry	chemistry	NOUN
ajst-32496	6	15	promotes	promote	VERB
ajst-32496	6	16	atom	atom	NOUN
ajst-32496	6	17	economy	economy	NOUN
ajst-32496	6	18	and	and	CCONJ
ajst-32496	6	19	environmental	environmental	ADJ
ajst-32496	6	20	sustainability	sustainability	NOUN
ajst-32496	6	21	;	;	PUNCT
ajst-32496	6	22	and	and	CCONJ
ajst-32496	6	23	electrochemical	electrochemical	ADJ
ajst-32496	6	24	synthesis	synthesis	NOUN
ajst-32496	6	25	introduces	introduce	VERB
ajst-32496	6	26	a	a	DET
ajst-32496	6	27	waste	waste	NOUN
ajst-32496	6	28	-	-	PUNCT
ajst-32496	6	29	free	free	ADJ
ajst-32496	6	30	,	,	PUNCT
ajst-32496	6	31	catalyst	catalyst	NOUN
ajst-32496	6	32	-	-	PUNCT
ajst-32496	6	33	efficient	efficient	ADJ
ajst-32496	6	34	approach	approach	NOUN
ajst-32496	6	35	suitable	suitable	ADJ
ajst-32496	6	36	for	for	ADP
ajst-32496	6	37	industrial	industrial	ADJ
ajst-32496	6	38	application	application	NOUN
ajst-32496	6	39	.	.	PUNCT
ajst-32496	7	1	case	case	NOUN
ajst-32496	7	2	studies	study	NOUN
ajst-32496	7	3	from	from	ADP
ajst-32496	7	4	leading	lead	VERB
ajst-32496	7	5	enterprises	enterprise	NOUN
ajst-32496	7	6	demonstrate	demonstrate	VERB
ajst-32496	7	7	that	that	SCONJ
ajst-32496	7	8	these	these	DET
ajst-32496	7	9	methods	method	NOUN
ajst-32496	7	10	significantly	significantly	ADV
ajst-32496	7	11	enhance	enhance	VERB
ajst-32496	7	12	product	product	NOUN
ajst-32496	7	13	yield	yield	NOUN
ajst-32496	7	14	,	,	PUNCT
ajst-32496	7	15	reduce	reduce	VERB
ajst-32496	7	16	carbon	carbon	NOUN
ajst-32496	7	17	emissions	emission	NOUN
ajst-32496	7	18	,	,	PUNCT
ajst-32496	7	19	and	and	CCONJ
ajst-32496	7	20	lower	low	ADJ
ajst-32496	7	21	resource	resource	NOUN
ajst-32496	7	22	consumption	consumption	NOUN
ajst-32496	7	23	.	.	PUNCT
ajst-32496	8	1	despite	despite	SCONJ
ajst-32496	8	2	these	these	DET
ajst-32496	8	3	advancements	advancement	NOUN
ajst-32496	8	4	,	,	PUNCT
ajst-32496	8	5	standardization	standardization	NOUN
ajst-32496	8	6	,	,	PUNCT
ajst-32496	8	7	high	high	ADJ
ajst-32496	8	8	equipment	equipment	NOUN
ajst-32496	8	9	cost	cost	NOUN
ajst-32496	8	10	,	,	PUNCT
ajst-32496	8	11	and	and	CCONJ
ajst-32496	8	12	interdisciplinary	interdisciplinary	ADJ
ajst-32496	8	13	technical	technical	ADJ
ajst-32496	8	14	barriers	barrier	NOUN
ajst-32496	8	15	remain	remain	VERB
ajst-32496	8	16	key	key	ADJ
ajst-32496	8	17	challenges	challenge	NOUN
ajst-32496	8	18	.	.	PUNCT
ajst-32496	9	1	the	the	DET
ajst-32496	9	2	study	study	NOUN
ajst-32496	9	3	concludes	conclude	VERB
ajst-32496	9	4	that	that	SCONJ
ajst-32496	9	5	integrating	integrate	VERB
ajst-32496	9	6	automation	automation	NOUN
ajst-32496	9	7	,	,	PUNCT
ajst-32496	9	8	artificial	artificial	ADJ
ajst-32496	9	9	intelligence	intelligence	NOUN
ajst-32496	9	10	,	,	PUNCT
ajst-32496	9	11	and	and	CCONJ
ajst-32496	9	12	modular	modular	ADJ
ajst-32496	9	13	electrochemical	electrochemical	ADJ
ajst-32496	9	14	systems	system	NOUN
ajst-32496	9	15	may	may	AUX
ajst-32496	9	16	further	far	ADV
ajst-32496	9	17	advance	advance	VERB
ajst-32496	9	18	sulphonamide	sulphonamide	ADJ
ajst-32496	9	19	synthesis	synthesis	NOUN
ajst-32496	9	20	toward	toward	ADP
ajst-32496	9	21	sustainable	sustainable	ADJ
ajst-32496	9	22	industrial	industrial	ADJ
ajst-32496	9	23	production	production	NOUN
ajst-32496	9	24	.	.	PUNCT
ajst-32496	10	1	keywords	keyword	NOUN
ajst-32496	10	2	:	:	PUNCT
ajst-32496	10	3	sulphonamide	sulphonamide	NOUN
ajst-32496	10	4	;	;	PUNCT
ajst-32496	10	5	green	green	ADJ
ajst-32496	10	6	chemistry	chemistry	NOUN
ajst-32496	10	7	;	;	PUNCT
ajst-32496	10	8	continuous	continuous	ADJ
ajst-32496	10	9	flow	flow	NOUN
ajst-32496	10	10	technology	technology	NOUN
ajst-32496	10	11	;	;	PUNCT
ajst-32496	10	12	sustainable	sustainable	ADJ
ajst-32496	10	13	pharmaceutical	pharmaceutical	NOUN
ajst-32496	10	14	production	production	NOUN
ajst-32496	10	15	;	;	PUNCT
ajst-32496	10	16	process	process	NOUN
ajst-32496	10	17	optimization	optimization	NOUN
ajst-32496	10	18	.	.	PUNCT
ajst-32496	11	1	1	1	X
ajst-32496	11	2	.	.	X
ajst-32496	11	3	introduction	introduction	NOUN
ajst-32496	11	4	the	the	DET
ajst-32496	11	5	discovery	discovery	NOUN
ajst-32496	11	6	of	of	ADP
ajst-32496	11	7	sulfonamides	sulfonamide	NOUN
ajst-32496	11	8	was	be	AUX
ajst-32496	11	9	the	the	DET
ajst-32496	11	10	original	original	ADJ
ajst-32496	11	11	and	and	CCONJ
ajst-32496	11	12	most	most	ADV
ajst-32496	11	13	historically	historically	ADV
ajst-32496	11	14	significant	significant	ADJ
ajst-32496	11	15	event	event	NOUN
ajst-32496	11	16	,	,	PUNCT
ajst-32496	11	17	revolutionizing	revolutionize	VERB
ajst-32496	11	18	the	the	DET
ajst-32496	11	19	field	field	NOUN
ajst-32496	11	20	of	of	ADP
ajst-32496	11	21	medicine	medicine	NOUN
ajst-32496	11	22	.	.	PUNCT
ajst-32496	12	1	the	the	DET
ajst-32496	12	2	sulfonamide	sulfonamide	NOUN
ajst-32496	12	3	is	be	AUX
ajst-32496	12	4	primarily	primarily	ADV
ajst-32496	12	5	used	use	VERB
ajst-32496	12	6	as	as	ADP
ajst-32496	12	7	an	an	DET
ajst-32496	12	8	antibacterial	antibacterial	ADJ
ajst-32496	12	9	agent	agent	NOUN
ajst-32496	12	10	to	to	PART
ajst-32496	12	11	treat	treat	VERB
ajst-32496	12	12	various	various	ADJ
ajst-32496	12	13	types	type	NOUN
ajst-32496	12	14	of	of	ADP
ajst-32496	12	15	bacterial	bacterial	ADJ
ajst-32496	12	16	infections	infection	NOUN
ajst-32496	12	17	.	.	PUNCT
ajst-32496	13	1	additionally	additionally	ADV
ajst-32496	13	2	,	,	PUNCT
ajst-32496	13	3	sulfonamides	sulfonamide	NOUN
ajst-32496	13	4	can	can	AUX
ajst-32496	13	5	act	act	VERB
ajst-32496	13	6	as	as	ADP
ajst-32496	13	7	diuretics	diuretic	NOUN
ajst-32496	13	8	,	,	PUNCT
ajst-32496	13	9	carbonic	carbonic	ADJ
ajst-32496	13	10	anhydrase	anhydrase	NOUN
ajst-32496	13	11	inhibitors	inhibitor	NOUN
ajst-32496	13	12	,	,	PUNCT
ajst-32496	13	13	and	and	CCONJ
ajst-32496	13	14	anti	anti	NOUN
ajst-32496	13	15	-	-	NOUN
ajst-32496	13	16	inflammatories	inflammatorie	NOUN
ajst-32496	13	17	.	.	PUNCT
ajst-32496	14	1	hence	hence	ADV
ajst-32496	14	2	,	,	PUNCT
ajst-32496	14	3	sulfonamide	sulfonamide	NOUN
ajst-32496	14	4	plays	play	VERB
ajst-32496	14	5	an	an	DET
ajst-32496	14	6	important	important	ADJ
ajst-32496	14	7	role	role	NOUN
ajst-32496	14	8	in	in	ADP
ajst-32496	14	9	pharmaceuticals	pharmaceutical	NOUN
ajst-32496	14	10	and	and	CCONJ
ajst-32496	14	11	agrochemicals	agrochemical	NOUN
ajst-32496	14	12	as	as	ADP
ajst-32496	14	13	a	a	DET
ajst-32496	14	14	structural	structural	ADJ
ajst-32496	14	15	unit	unit	NOUN
ajst-32496	14	16	.	.	PUNCT
ajst-32496	15	1	nowadays	nowadays	ADV
ajst-32496	15	2	,	,	PUNCT
ajst-32496	15	3	there	there	PRON
ajst-32496	15	4	are	be	VERB
ajst-32496	15	5	various	various	ADJ
ajst-32496	15	6	methods	method	NOUN
ajst-32496	15	7	for	for	ADP
ajst-32496	15	8	synthesizing	synthesize	VERB
ajst-32496	15	9	sulfonamides	sulfonamide	NOUN
ajst-32496	15	10	.	.	PUNCT
ajst-32496	16	1	to	to	ADP
ajst-32496	16	2	date	date	NOUN
ajst-32496	16	3	,	,	PUNCT
ajst-32496	16	4	several	several	ADJ
ajst-32496	16	5	issues	issue	NOUN
ajst-32496	16	6	have	have	AUX
ajst-32496	16	7	been	be	AUX
ajst-32496	16	8	identified	identify	VERB
ajst-32496	16	9	in	in	ADP
ajst-32496	16	10	the	the	DET
ajst-32496	16	11	synthesis	synthesis	NOUN
ajst-32496	16	12	of	of	ADP
ajst-32496	16	13	sulfonamides	sulfonamide	NOUN
ajst-32496	16	14	,	,	PUNCT
ajst-32496	16	15	including	include	VERB
ajst-32496	16	16	reagent	reagent	ADJ
ajst-32496	16	17	stability	stability	NOUN
ajst-32496	16	18	,	,	PUNCT
ajst-32496	16	19	reaction	reaction	NOUN
ajst-32496	16	20	conditions	condition	NOUN
ajst-32496	16	21	,	,	PUNCT
ajst-32496	16	22	operational	operational	ADJ
ajst-32496	16	23	steps	step	NOUN
ajst-32496	16	24	,	,	PUNCT
ajst-32496	16	25	and	and	CCONJ
ajst-32496	16	26	environmental	environmental	ADJ
ajst-32496	16	27	friendliness	friendliness	NOUN
ajst-32496	16	28	.	.	PUNCT
ajst-32496	17	1	for	for	ADP
ajst-32496	17	2	example	example	NOUN
ajst-32496	17	3	,	,	PUNCT
ajst-32496	17	4	the	the	DET
ajst-32496	17	5	classical	classical	ADJ
ajst-32496	17	6	method	method	NOUN
ajst-32496	17	7	,	,	PUNCT
ajst-32496	17	8	the	the	DET
ajst-32496	17	9	reaction	reaction	NOUN
ajst-32496	17	10	between	between	ADP
ajst-32496	17	11	sulfonyl	sulfonyl	NOUN
ajst-32496	17	12	chloride	chloride	NOUN
ajst-32496	17	13	and	and	CCONJ
ajst-32496	17	14	an	an	DET
ajst-32496	17	15	amine	amine	NOUN
ajst-32496	17	16	,	,	PUNCT
ajst-32496	17	17	has	have	VERB
ajst-32496	17	18	highly	highly	ADV
ajst-32496	17	19	stringent	stringent	ADJ
ajst-32496	17	20	requirements	requirement	NOUN
ajst-32496	17	21	for	for	ADP
ajst-32496	17	22	reaction	reaction	NOUN
ajst-32496	17	23	conditions	condition	NOUN
ajst-32496	17	24	,	,	PUNCT
ajst-32496	17	25	as	as	SCONJ
ajst-32496	17	26	sulfonyl	sulfonyl	NOUN
ajst-32496	17	27	chloride	chloride	NOUN
ajst-32496	17	28	is	be	AUX
ajst-32496	17	29	hydrolytically	hydrolytically	ADV
ajst-32496	17	30	responsive	responsive	ADJ
ajst-32496	17	31	and	and	CCONJ
ajst-32496	17	32	a	a	DET
ajst-32496	17	33	corrosive	corrosive	ADJ
ajst-32496	17	34	and	and	CCONJ
ajst-32496	17	35	toxic	toxic	ADJ
ajst-32496	17	36	reagent	reagent	NOUN
ajst-32496	17	37	that	that	PRON
ajst-32496	17	38	should	should	AUX
ajst-32496	17	39	be	be	AUX
ajst-32496	17	40	handled	handle	VERB
ajst-32496	17	41	with	with	ADP
ajst-32496	17	42	care	care	NOUN
ajst-32496	17	43	.	.	PUNCT
ajst-32496	18	1	however	however	ADV
ajst-32496	18	2	,	,	PUNCT
ajst-32496	18	3	there	there	PRON
ajst-32496	18	4	are	be	VERB
ajst-32496	18	5	several	several	ADJ
ajst-32496	18	6	methods	method	NOUN
ajst-32496	18	7	for	for	ADP
ajst-32496	18	8	synthesizing	synthesize	VERB
ajst-32496	18	9	sulfonamides	sulfonamide	NOUN
ajst-32496	18	10	,	,	PUNCT
ajst-32496	18	11	including	include	VERB
ajst-32496	18	12	oxidative	oxidative	ADJ
ajst-32496	18	13	coupling	coupling	NOUN
ajst-32496	18	14	and	and	CCONJ
ajst-32496	18	15	the	the	DET
ajst-32496	18	16	reaction	reaction	NOUN
ajst-32496	18	17	with	with	ADP
ajst-32496	18	18	diphenylurea	diphenylurea	NOUN
ajst-32496	18	19	.	.	PUNCT
ajst-32496	19	1	most	most	ADJ
ajst-32496	19	2	have	have	VERB
ajst-32496	19	3	some	some	DET
ajst-32496	19	4	challenges	challenge	NOUN
ajst-32496	19	5	,	,	PUNCT
ajst-32496	19	6	such	such	ADJ
ajst-32496	19	7	as	as	ADP
ajst-32496	19	8	function	function	NOUN
ajst-32496	19	9	group	group	NOUN
ajst-32496	19	10	tolerance	tolerance	NOUN
ajst-32496	19	11	,	,	PUNCT
ajst-32496	19	12	atomic	atomic	ADJ
ajst-32496	19	13	economy	economy	NOUN
ajst-32496	19	14	,	,	PUNCT
ajst-32496	19	15	environmental	environmental	ADJ
ajst-32496	19	16	impact	impact	NOUN
ajst-32496	19	17	,	,	PUNCT
ajst-32496	19	18	and	and	CCONJ
ajst-32496	19	19	cost	cost	NOUN
ajst-32496	19	20	and	and	CCONJ
ajst-32496	19	21	operation	operation	NOUN
ajst-32496	19	22	.	.	PUNCT
ajst-32496	20	1	hence	hence	ADV
ajst-32496	20	2	,	,	PUNCT
ajst-32496	20	3	it	it	PRON
ajst-32496	20	4	is	be	AUX
ajst-32496	20	5	essential	essential	ADJ
ajst-32496	20	6	to	to	PART
ajst-32496	20	7	optimize	optimize	VERB
ajst-32496	20	8	the	the	DET
ajst-32496	20	9	traditional	traditional	ADJ
ajst-32496	20	10	method	method	NOUN
ajst-32496	20	11	by	by	ADP
ajst-32496	20	12	developing	develop	VERB
ajst-32496	20	13	new	new	ADJ
ajst-32496	20	14	reagents	reagent	NOUN
ajst-32496	20	15	and	and	CCONJ
ajst-32496	20	16	processes	process	NOUN
ajst-32496	20	17	,	,	PUNCT
ajst-32496	20	18	as	as	ADV
ajst-32496	20	19	well	well	ADV
ajst-32496	20	20	as	as	ADP
ajst-32496	20	21	optimizing	optimize	VERB
ajst-32496	20	22	existing	exist	VERB
ajst-32496	20	23	conditions	condition	NOUN
ajst-32496	20	24	,	,	PUNCT
ajst-32496	20	25	to	to	PART
ajst-32496	20	26	reduce	reduce	VERB
ajst-32496	20	27	the	the	DET
ajst-32496	20	28	environmental	environmental	ADJ
ajst-32496	20	29	impact	impact	NOUN
ajst-32496	20	30	of	of	ADP
ajst-32496	20	31	reagents	reagent	NOUN
ajst-32496	20	32	and	and	CCONJ
ajst-32496	20	33	products	product	NOUN
ajst-32496	20	34	,	,	PUNCT
ajst-32496	20	35	and	and	CCONJ
ajst-32496	20	36	minimize	minimize	VERB
ajst-32496	20	37	by	by	ADP
ajst-32496	20	38	-	-	PUNCT
ajst-32496	20	39	products	product	NOUN
ajst-32496	20	40	,	,	PUNCT
ajst-32496	20	41	thereby	thereby	ADV
ajst-32496	20	42	increasing	increase	VERB
ajst-32496	20	43	yield	yield	NOUN
ajst-32496	20	44	.	.	PUNCT
ajst-32496	21	1	137	137	NUM
ajst-32496	21	2	figure	figure	NOUN
ajst-32496	21	3	1	1	NUM
ajst-32496	21	4	.	.	PUNCT
ajst-32496	21	5	common	common	ADJ
ajst-32496	21	6	types	type	NOUN
ajst-32496	21	7	of	of	ADP
ajst-32496	21	8	sulphanilamide	sulphanilamide	NOUN
ajst-32496	21	9	.	.	PUNCT
ajst-32496	22	1	1	1	NUM
ajst-32496	22	2	:	:	PUNCT
ajst-32496	22	3	sulphanilamide	sulphanilamide	ADJ
ajst-32496	22	4	,	,	PUNCT
ajst-32496	22	5	2	2	NUM
ajst-32496	22	6	:	:	PUNCT
ajst-32496	22	7	sulfisoxazole	sulfisoxazole	NOUN
ajst-32496	22	8	(	(	PUNCT
ajst-32496	22	9	siz	siz	PROPN
ajst-32496	22	10	)	)	PUNCT
ajst-32496	22	11	,	,	PUNCT
ajst-32496	22	12	3	3	NUM
ajst-32496	22	13	:	:	PUNCT
ajst-32496	22	14	sulfamethoxazole	sulfamethoxazole	NOUN
ajst-32496	22	15	(	(	PUNCT
ajst-32496	22	16	smz	smz	NOUN
ajst-32496	22	17	)	)	PUNCT
ajst-32496	22	18	,	,	PUNCT
ajst-32496	22	19	4	4	NUM
ajst-32496	22	20	:	:	PUNCT
ajst-32496	22	21	sulfadiazine	sulfadiazine	NOUN
ajst-32496	22	22	silver	silver	PROPN
ajst-32496	22	23	sulphanilamide	sulphanilamide	NOUN
ajst-32496	22	24	is	be	AUX
ajst-32496	22	25	a	a	DET
ajst-32496	22	26	tertiary	tertiary	ADJ
ajst-32496	22	27	compound	compound	NOUN
ajst-32496	22	28	characterized	characterize	VERB
ajst-32496	22	29	by	by	ADP
ajst-32496	22	30	a	a	DET
ajst-32496	22	31	central	central	ADJ
ajst-32496	22	32	sulfur	sulfur	NOUN
ajst-32496	22	33	atom	atom	NOUN
ajst-32496	22	34	double	double	ADV
ajst-32496	22	35	-	-	PUNCT
ajst-32496	22	36	bonded	bond	VERB
ajst-32496	22	37	to	to	ADP
ajst-32496	22	38	two	two	NUM
ajst-32496	22	39	oxygen	oxygen	NOUN
ajst-32496	22	40	atoms	atom	NOUN
ajst-32496	22	41	and	and	CCONJ
ajst-32496	22	42	singly	singly	ADV
ajst-32496	22	43	bonded	bond	VERB
ajst-32496	22	44	to	to	ADP
ajst-32496	22	45	both	both	PRON
ajst-32496	22	46	a	a	DET
ajst-32496	22	47	substituted	substitute	VERB
ajst-32496	22	48	amine	amine	NOUN
ajst-32496	22	49	and	and	CCONJ
ajst-32496	22	50	an	an	DET
ajst-32496	22	51	aniline	aniline	NOUN
ajst-32496	22	52	group	group	NOUN
ajst-32496	22	53	,	,	PUNCT
ajst-32496	22	54	forming	form	VERB
ajst-32496	22	55	its	its	PRON
ajst-32496	22	56	typical	typical	ADJ
ajst-32496	22	57	sulfonamide	sulfonamide	NOUN
ajst-32496	22	58	structure	structure	NOUN
ajst-32496	22	59	.	.	PUNCT
ajst-32496	23	1	traditionally	traditionally	ADV
ajst-32496	23	2	,	,	PUNCT
ajst-32496	23	3	it	it	PRON
ajst-32496	23	4	is	be	AUX
ajst-32496	23	5	synthesized	synthesize	VERB
ajst-32496	23	6	through	through	ADP
ajst-32496	23	7	a	a	DET
ajst-32496	23	8	five	five	NUM
ajst-32496	23	9	-	-	PUNCT
ajst-32496	23	10	step	step	NOUN
ajst-32496	23	11	process	process	NOUN
ajst-32496	23	12	:	:	PUNCT
ajst-32496	23	13	the	the	DET
ajst-32496	23	14	reduction	reduction	NOUN
ajst-32496	23	15	of	of	ADP
ajst-32496	23	16	nitrobenzene	nitrobenzene	NOUN
ajst-32496	23	17	to	to	ADP
ajst-32496	23	18	aniline	aniline	NOUN
ajst-32496	23	19	,	,	PUNCT
ajst-32496	23	20	acetylation	acetylation	NOUN
ajst-32496	23	21	to	to	PART
ajst-32496	23	22	form	form	VERB
ajst-32496	23	23	acetanilide	acetanilide	ADV
ajst-32496	23	24	,	,	PUNCT
ajst-32496	23	25	chlorosulfonation	chlorosulfonation	NOUN
ajst-32496	23	26	to	to	PART
ajst-32496	23	27	yield	yield	VERB
ajst-32496	23	28	4acetaminobenzenesulfonyl	4acetaminobenzenesulfonyl	NUM
ajst-32496	23	29	chloride	chloride	NOUN
ajst-32496	23	30	,	,	PUNCT
ajst-32496	23	31	subsequent	subsequent	ADJ
ajst-32496	23	32	amidation	amidation	NOUN
ajst-32496	23	33	with	with	ADP
ajst-32496	23	34	ammonia	ammonia	NOUN
ajst-32496	23	35	to	to	PART
ajst-32496	23	36	form	form	VERB
ajst-32496	23	37	4acetamidobenzenesulfonamide	4acetamidobenzenesulfonamide	NUM
ajst-32496	23	38	,	,	PUNCT
ajst-32496	23	39	and	and	CCONJ
ajst-32496	23	40	final	final	ADJ
ajst-32496	23	41	acid	acid	NOUN
ajst-32496	23	42	hydrolysis	hydrolysis	NOUN
ajst-32496	23	43	to	to	PART
ajst-32496	23	44	obtain	obtain	VERB
ajst-32496	23	45	pure	pure	ADJ
ajst-32496	23	46	sulphanilamide	sulphanilamide	NOUN
ajst-32496	23	47	.	.	PUNCT
ajst-32496	24	1	this	this	DET
ajst-32496	24	2	multistep	multistep	ADJ
ajst-32496	24	3	synthesis	synthesis	NOUN
ajst-32496	24	4	,	,	PUNCT
ajst-32496	24	5	while	while	SCONJ
ajst-32496	24	6	effective	effective	ADJ
ajst-32496	24	7	,	,	PUNCT
ajst-32496	24	8	involves	involve	VERB
ajst-32496	24	9	complex	complex	ADJ
ajst-32496	24	10	reactions	reaction	NOUN
ajst-32496	24	11	and	and	CCONJ
ajst-32496	24	12	multiple	multiple	ADJ
ajst-32496	24	13	purification	purification	NOUN
ajst-32496	24	14	stages	stage	NOUN
ajst-32496	24	15	.	.	PUNCT
ajst-32496	25	1	based	base	VERB
ajst-32496	25	2	on	on	ADP
ajst-32496	25	3	this	this	DET
ajst-32496	25	4	traditional	traditional	ADJ
ajst-32496	25	5	method	method	NOUN
ajst-32496	25	6	for	for	ADP
ajst-32496	25	7	synthesising	synthesise	VERB
ajst-32496	25	8	sulphanilamide	sulphanilamide	NOUN
ajst-32496	25	9	,	,	PUNCT
ajst-32496	25	10	we	we	PRON
ajst-32496	25	11	identified	identify	VERB
ajst-32496	25	12	certain	certain	ADJ
ajst-32496	25	13	drawbacks	drawback	NOUN
ajst-32496	25	14	and	and	CCONJ
ajst-32496	25	15	limitations	limitation	NOUN
ajst-32496	25	16	associated	associate	VERB
ajst-32496	25	17	with	with	ADP
ajst-32496	25	18	it	it	PRON
ajst-32496	25	19	.	.	PUNCT
ajst-32496	26	1	for	for	ADP
ajst-32496	26	2	instance	instance	NOUN
ajst-32496	26	3	,	,	PUNCT
ajst-32496	26	4	the	the	DET
ajst-32496	26	5	reaction	reaction	NOUN
ajst-32496	26	6	conditions	condition	NOUN
ajst-32496	26	7	are	be	AUX
ajst-32496	26	8	demanding	demand	VERB
ajst-32496	26	9	,	,	PUNCT
ajst-32496	26	10	with	with	ADP
ajst-32496	26	11	numerous	numerous	ADJ
ajst-32496	26	12	by	by	ADP
ajst-32496	26	13	-	-	PUNCT
ajst-32496	26	14	products	product	NOUN
ajst-32496	26	15	generated	generate	VERB
ajst-32496	26	16	during	during	ADP
ajst-32496	26	17	the	the	DET
ajst-32496	26	18	process	process	NOUN
ajst-32496	26	19	and	and	CCONJ
ajst-32496	26	20	a	a	DET
ajst-32496	26	21	relatively	relatively	ADV
ajst-32496	26	22	low	low	ADJ
ajst-32496	26	23	yield	yield	NOUN
ajst-32496	26	24	.	.	PUNCT
ajst-32496	27	1	2	2	X
ajst-32496	27	2	.	.	NUM
ajst-32496	27	3	conventional	conventional	ADJ
ajst-32496	27	4	sulphanilamide	sulphanilamide	ADJ
ajst-32496	27	5	synthesis	synthesis	NOUN
ajst-32496	27	6	method	method	NOUN
ajst-32496	27	7	2.1	2.1	NUM
ajst-32496	27	8	detailed	detailed	ADJ
ajst-32496	27	9	mechanism	mechanism	NOUN
ajst-32496	27	10	the	the	DET
ajst-32496	27	11	synthesis	synthesis	NOUN
ajst-32496	27	12	of	of	ADP
ajst-32496	27	13	sulphanilamide	sulphanilamide	NOUN
ajst-32496	27	14	follows	follow	VERB
ajst-32496	27	15	a	a	DET
ajst-32496	27	16	sequential	sequential	ADJ
ajst-32496	27	17	reaction	reaction	NOUN
ajst-32496	27	18	pathway	pathway	NOUN
ajst-32496	27	19	involving	involve	VERB
ajst-32496	27	20	reduction	reduction	NOUN
ajst-32496	27	21	,	,	PUNCT
ajst-32496	27	22	acetylation	acetylation	NOUN
ajst-32496	27	23	,	,	PUNCT
ajst-32496	27	24	electrophilic	electrophilic	ADJ
ajst-32496	27	25	substitution	substitution	NOUN
ajst-32496	27	26	,	,	PUNCT
ajst-32496	27	27	amide	amide	NOUN
ajst-32496	27	28	formation	formation	NOUN
ajst-32496	27	29	,	,	PUNCT
ajst-32496	27	30	and	and	CCONJ
ajst-32496	27	31	deprotection	deprotection	NOUN
ajst-32496	27	32	.	.	PUNCT
ajst-32496	28	1	the	the	DET
ajst-32496	28	2	process	process	NOUN
ajst-32496	28	3	strategically	strategically	ADV
ajst-32496	28	4	employs	employ	VERB
ajst-32496	28	5	a	a	DET
ajst-32496	28	6	protecting	protect	VERB
ajst-32496	28	7	group	group	NOUN
ajst-32496	28	8	to	to	PART
ajst-32496	28	9	ensure	ensure	VERB
ajst-32496	28	10	selective	selective	ADJ
ajst-32496	28	11	electrophilic	electrophilic	ADJ
ajst-32496	28	12	substitution	substitution	NOUN
ajst-32496	28	13	on	on	ADP
ajst-32496	28	14	the	the	DET
ajst-32496	28	15	aromatic	aromatic	ADJ
ajst-32496	28	16	ring	ring	NOUN
ajst-32496	28	17	while	while	SCONJ
ajst-32496	28	18	preventing	prevent	VERB
ajst-32496	28	19	interference	interference	NOUN
ajst-32496	28	20	from	from	ADP
ajst-32496	28	21	the	the	DET
ajst-32496	28	22	amino	amino	NOUN
ajst-32496	28	23	group	group	NOUN
ajst-32496	28	24	.	.	PUNCT
ajst-32496	29	1	in	in	ADP
ajst-32496	29	2	the	the	DET
ajst-32496	29	3	first	first	ADJ
ajst-32496	29	4	step	step	NOUN
ajst-32496	29	5	,	,	PUNCT
ajst-32496	29	6	nitrobenzene	nitrobenzene	PROPN
ajst-32496	29	7	is	be	AUX
ajst-32496	29	8	reduced	reduce	VERB
ajst-32496	29	9	to	to	ADP
ajst-32496	29	10	aniline	aniline	NOUN
ajst-32496	29	11	using	use	VERB
ajst-32496	29	12	tin	tin	NOUN
ajst-32496	29	13	(	(	PUNCT
ajst-32496	29	14	sn	sn	NOUN
ajst-32496	29	15	)	)	PUNCT
ajst-32496	29	16	and	and	CCONJ
ajst-32496	29	17	hydrochloric	hydrochloric	ADJ
ajst-32496	29	18	acid	acid	NOUN
ajst-32496	29	19	.	.	PUNCT
ajst-32496	30	1	during	during	ADP
ajst-32496	30	2	this	this	DET
ajst-32496	30	3	reaction	reaction	NOUN
ajst-32496	30	4	,	,	PUNCT
ajst-32496	30	5	hydrogenation	hydrogenation	NOUN
ajst-32496	30	6	targets	target	VERB
ajst-32496	30	7	the	the	DET
ajst-32496	30	8	nitro	nitro	NOUN
ajst-32496	30	9	group	group	NOUN
ajst-32496	30	10	rather	rather	ADV
ajst-32496	30	11	than	than	ADP
ajst-32496	30	12	the	the	DET
ajst-32496	30	13	benzene	benzene	NOUN
ajst-32496	30	14	ring	ring	NOUN
ajst-32496	30	15	because	because	SCONJ
ajst-32496	30	16	the	the	DET
ajst-32496	30	17	energy	energy	NOUN
ajst-32496	30	18	barrier	barrier	NOUN
ajst-32496	30	19	for	for	ADP
ajst-32496	30	20	nitro	nitro	NOUN
ajst-32496	30	21	reduction	reduction	NOUN
ajst-32496	30	22	is	be	AUX
ajst-32496	30	23	significantly	significantly	ADV
ajst-32496	30	24	lower	low	ADJ
ajst-32496	30	25	.	.	PUNCT
ajst-32496	31	1	the	the	DET
ajst-32496	31	2	nitro	nitro	PROPN
ajst-32496	31	3	group	group	NOUN
ajst-32496	31	4	undergoes	undergo	VERB
ajst-32496	31	5	progressive	progressive	ADJ
ajst-32496	31	6	hydrogenation	hydrogenation	NOUN
ajst-32496	31	7	through	through	ADP
ajst-32496	31	8	hydroxylamine	hydroxylamine	ADJ
ajst-32496	31	9	intermediates	intermediate	NOUN
ajst-32496	31	10	,	,	PUNCT
ajst-32496	31	11	eventually	eventually	ADV
ajst-32496	31	12	forming	form	VERB
ajst-32496	31	13	aniline	aniline	NOUN
ajst-32496	31	14	.	.	PUNCT
ajst-32496	32	1	next	next	ADJ
ajst-32496	32	2	,	,	PUNCT
ajst-32496	32	3	aniline	aniline	NOUN
ajst-32496	32	4	undergoes	undergoe	NOUN
ajst-32496	32	5	acetylation	acetylation	NOUN
ajst-32496	32	6	with	with	ADP
ajst-32496	32	7	acetic	acetic	ADJ
ajst-32496	32	8	anhydride	anhydride	NOUN
ajst-32496	32	9	to	to	PART
ajst-32496	32	10	produce	produce	VERB
ajst-32496	32	11	acetanilide	acetanilide	ADV
ajst-32496	32	12	.	.	PUNCT
ajst-32496	33	1	the	the	DET
ajst-32496	33	2	nitrogen	nitrogen	NOUN
ajst-32496	33	3	atom	atom	NOUN
ajst-32496	33	4	in	in	ADP
ajst-32496	33	5	aniline	aniline	NOUN
ajst-32496	33	6	acts	act	NOUN
ajst-32496	33	7	as	as	ADP
ajst-32496	33	8	a	a	DET
ajst-32496	33	9	nucleophile	nucleophile	NOUN
ajst-32496	33	10	.	.	PUNCT
ajst-32496	34	1	it	it	PRON
ajst-32496	34	2	attacks	attack	VERB
ajst-32496	34	3	the	the	DET
ajst-32496	34	4	carbonyl	carbonyl	NOUN
ajst-32496	34	5	carbon	carbon	NOUN
ajst-32496	34	6	of	of	ADP
ajst-32496	34	7	acetic	acetic	ADJ
ajst-32496	34	8	anhydride	anhydride	NOUN
ajst-32496	34	9	,	,	PUNCT
ajst-32496	34	10	forming	form	VERB
ajst-32496	34	11	a	a	DET
ajst-32496	34	12	tetrahedral	tetrahedral	ADJ
ajst-32496	34	13	intermediate	intermediate	NOUN
ajst-32496	34	14	that	that	PRON
ajst-32496	34	15	rearranges	rearrange	VERB
ajst-32496	34	16	to	to	PART
ajst-32496	34	17	release	release	VERB
ajst-32496	34	18	acetic	acetic	ADJ
ajst-32496	34	19	acid	acid	NOUN
ajst-32496	34	20	and	and	CCONJ
ajst-32496	34	21	yield	yield	VERB
ajst-32496	34	22	the	the	DET
ajst-32496	34	23	protected	protect	VERB
ajst-32496	34	24	amide	amide	NOUN
ajst-32496	34	25	.	.	PUNCT
ajst-32496	35	1	the	the	DET
ajst-32496	35	2	third	third	ADJ
ajst-32496	35	3	stage	stage	NOUN
ajst-32496	35	4	involves	involve	VERB
ajst-32496	35	5	chlorosulfonation	chlorosulfonation	NOUN
ajst-32496	35	6	,	,	PUNCT
ajst-32496	35	7	in	in	ADP
ajst-32496	35	8	which	which	PRON
ajst-32496	35	9	acetanilide	acetanilide	ADJ
ajst-32496	35	10	reacts	react	VERB
ajst-32496	35	11	with	with	ADP
ajst-32496	35	12	chlorosulfonic	chlorosulfonic	ADJ
ajst-32496	35	13	acid	acid	NOUN
ajst-32496	35	14	(	(	PUNCT
ajst-32496	35	15	clso₃h	clso₃h	NOUN
ajst-32496	35	16	)	)	PUNCT
ajst-32496	35	17	to	to	PART
ajst-32496	35	18	generate	generate	VERB
ajst-32496	35	19	p	p	NOUN
ajst-32496	35	20	-	-	PUNCT
ajst-32496	35	21	acetamidobenzenesulfonyl	acetamidobenzenesulfonyl	NOUN
ajst-32496	35	22	chloride	chloride	NOUN
ajst-32496	35	23	.	.	PUNCT
ajst-32496	36	1	chlorosulfonic	chlorosulfonic	ADJ
ajst-32496	36	2	acid	acid	NOUN
ajst-32496	36	3	serves	serve	VERB
ajst-32496	36	4	both	both	PRON
ajst-32496	36	5	as	as	ADP
ajst-32496	36	6	a	a	DET
ajst-32496	36	7	reagent	reagent	NOUN
ajst-32496	36	8	and	and	CCONJ
ajst-32496	36	9	solvent	solvent	NOUN
ajst-32496	36	10	,	,	PUNCT
ajst-32496	36	11	forming	form	VERB
ajst-32496	36	12	electrophilic	electrophilic	ADJ
ajst-32496	36	13	chlorosulfonic	chlorosulfonic	ADJ
ajst-32496	36	14	cations	cation	NOUN
ajst-32496	36	15	that	that	PRON
ajst-32496	36	16	attack	attack	VERB
ajst-32496	36	17	the	the	DET
ajst-32496	36	18	activated	activate	VERB
ajst-32496	36	19	paraposition	paraposition	NOUN
ajst-32496	36	20	of	of	ADP
ajst-32496	36	21	the	the	DET
ajst-32496	36	22	benzene	benzene	NOUN
ajst-32496	36	23	ring	ring	NOUN
ajst-32496	36	24	.	.	PUNCT
ajst-32496	37	1	the	the	DET
ajst-32496	37	2	intermediate	intermediate	ADJ
ajst-32496	37	3	sulfonic	sulfonic	ADJ
ajst-32496	37	4	acid	acid	NOUN
ajst-32496	37	5	subsequently	subsequently	ADV
ajst-32496	37	6	converts	convert	VERB
ajst-32496	37	7	into	into	ADP
ajst-32496	37	8	sulfonyl	sulfonyl	NOUN
ajst-32496	37	9	chloride	chloride	NOUN
ajst-32496	37	10	(	(	PUNCT
ajst-32496	37	11	-so₂cl	-so₂cl	NUM
ajst-32496	37	12	)	)	PUNCT
ajst-32496	37	13	under	under	ADP
ajst-32496	37	14	excess	excess	ADJ
ajst-32496	37	15	reagent	reagent	NOUN
ajst-32496	37	16	.	.	PUNCT
ajst-32496	38	1	the	the	DET
ajst-32496	38	2	fourth	fourth	ADJ
ajst-32496	38	3	stage	stage	NOUN
ajst-32496	38	4	proceeds	proceed	VERB
ajst-32496	38	5	through	through	ADP
ajst-32496	38	6	nucleophilic	nucleophilic	ADJ
ajst-32496	38	7	substitution	substitution	NOUN
ajst-32496	38	8	,	,	PUNCT
ajst-32496	38	9	where	where	SCONJ
ajst-32496	38	10	ammonia	ammonia	NOUN
ajst-32496	38	11	reacts	react	VERB
ajst-32496	38	12	with	with	ADP
ajst-32496	38	13	the	the	DET
ajst-32496	38	14	sulfonyl	sulfonyl	ADJ
ajst-32496	38	15	chloride	chloride	NOUN
ajst-32496	38	16	to	to	PART
ajst-32496	38	17	form	form	VERB
ajst-32496	38	18	4	4	NUM
ajst-32496	38	19	-	-	NOUN
ajst-32496	38	20	acetamidobenzenesulfonamide	acetamidobenzenesulfonamide	ADJ
ajst-32496	38	21	.	.	PUNCT
ajst-32496	39	1	the	the	DET
ajst-32496	39	2	nitrogen	nitrogen	NOUN
ajst-32496	39	3	atom	atom	NOUN
ajst-32496	39	4	of	of	ADP
ajst-32496	39	5	ammonia	ammonia	NOUN
ajst-32496	39	6	donates	donate	VERB
ajst-32496	39	7	its	its	PRON
ajst-32496	39	8	lone	lone	ADJ
ajst-32496	39	9	pair	pair	NOUN
ajst-32496	39	10	to	to	ADP
ajst-32496	39	11	the	the	DET
ajst-32496	39	12	electrophilic	electrophilic	ADJ
ajst-32496	39	13	sulfur	sulfur	NOUN
ajst-32496	39	14	atom	atom	NOUN
ajst-32496	39	15	,	,	PUNCT
ajst-32496	39	16	forming	form	VERB
ajst-32496	39	17	a	a	DET
ajst-32496	39	18	transient	transient	ADJ
ajst-32496	39	19	tetrahedral	tetrahedral	ADJ
ajst-32496	39	20	intermediate	intermediate	NOUN
ajst-32496	39	21	that	that	PRON
ajst-32496	39	22	collapses	collapse	VERB
ajst-32496	39	23	with	with	ADP
ajst-32496	39	24	chloride	chloride	NOUN
ajst-32496	39	25	ion	ion	NOUN
ajst-32496	39	26	elimination	elimination	NOUN
ajst-32496	39	27	,	,	PUNCT
ajst-32496	39	28	restoring	restore	VERB
ajst-32496	39	29	the	the	DET
ajst-32496	39	30	s	s	PROPN
ajst-32496	39	31	=	=	NOUN
ajst-32496	39	32	o	o	NOUN
ajst-32496	39	33	bond	bond	NOUN
ajst-32496	39	34	.	.	PUNCT
ajst-32496	40	1	finally	finally	ADV
ajst-32496	40	2	,	,	PUNCT
ajst-32496	40	3	acidic	acidic	ADJ
ajst-32496	40	4	hydrolysis	hydrolysis	NOUN
ajst-32496	40	5	removes	remove	VERB
ajst-32496	40	6	the	the	DET
ajst-32496	40	7	acetyl	acetyl	NOUN
ajst-32496	40	8	protecting	protect	VERB
ajst-32496	40	9	group	group	NOUN
ajst-32496	40	10	to	to	PART
ajst-32496	40	11	produce	produce	VERB
ajst-32496	40	12	sulphanilamide	sulphanilamide	NOUN
ajst-32496	40	13	.	.	PUNCT
ajst-32496	41	1	protonation	protonation	NOUN
ajst-32496	41	2	of	of	ADP
ajst-32496	41	3	the	the	DET
ajst-32496	41	4	carbonyl	carbonyl	NOUN
ajst-32496	41	5	oxygen	oxygen	NOUN
ajst-32496	41	6	enhances	enhance	VERB
ajst-32496	41	7	electrophilicity	electrophilicity	NOUN
ajst-32496	41	8	,	,	PUNCT
ajst-32496	41	9	allowing	allow	VERB
ajst-32496	41	10	water	water	NOUN
ajst-32496	41	11	to	to	PART
ajst-32496	41	12	attack	attack	VERB
ajst-32496	41	13	the	the	DET
ajst-32496	41	14	carbonyl	carbonyl	NOUN
ajst-32496	41	15	1	1	NUM
ajst-32496	41	16	.	.	NOUN
ajst-32496	41	17	2	2	NUM
ajst-32496	41	18	.	.	NOUN
ajst-32496	41	19	3	3	NUM
ajst-32496	41	20	.	.	NOUN
ajst-32496	41	21	4	4	NUM
ajst-32496	41	22	.	.	NOUN
ajst-32496	41	23	138	138	NUM
ajst-32496	41	24	carbon	carbon	NOUN
ajst-32496	41	25	.	.	PUNCT
ajst-32496	42	1	the	the	DET
ajst-32496	42	2	resulting	result	VERB
ajst-32496	42	3	intermediate	intermediate	ADJ
ajst-32496	42	4	decomposes	decompose	NOUN
ajst-32496	42	5	,	,	PUNCT
ajst-32496	42	6	generating	generate	VERB
ajst-32496	42	7	acetic	acetic	ADJ
ajst-32496	42	8	acid	acid	NOUN
ajst-32496	42	9	and	and	CCONJ
ajst-32496	42	10	releasing	release	VERB
ajst-32496	42	11	the	the	DET
ajst-32496	42	12	free	free	ADJ
ajst-32496	42	13	amino	amino	NOUN
ajst-32496	42	14	group	group	NOUN
ajst-32496	42	15	(	(	PUNCT
ajst-32496	42	16	-nh₂	-nh₂	NOUN
ajst-32496	42	17	)	)	PUNCT
ajst-32496	42	18	.	.	PUNCT
ajst-32496	43	1	this	this	DET
ajst-32496	43	2	multi	multi	ADJ
ajst-32496	43	3	-	-	ADJ
ajst-32496	43	4	step	step	ADJ
ajst-32496	43	5	mechanism	mechanism	NOUN
ajst-32496	43	6	efficiently	efficiently	ADV
ajst-32496	43	7	constructs	construct	VERB
ajst-32496	43	8	sulphanilamide	sulphanilamide	ADV
ajst-32496	43	9	by	by	ADP
ajst-32496	43	10	integrating	integrate	VERB
ajst-32496	43	11	protection	protection	NOUN
ajst-32496	43	12	–	–	PUNCT
ajst-32496	43	13	deprotection	deprotection	NOUN
ajst-32496	43	14	strategies	strategy	NOUN
ajst-32496	43	15	and	and	CCONJ
ajst-32496	43	16	controlled	control	VERB
ajst-32496	43	17	electrophilic	electrophilic	ADJ
ajst-32496	43	18	substitution	substitution	NOUN
ajst-32496	43	19	,	,	PUNCT
ajst-32496	43	20	ensuring	ensure	VERB
ajst-32496	43	21	regioselective	regioselective	ADJ
ajst-32496	43	22	sulfonation	sulfonation	NOUN
ajst-32496	43	23	while	while	SCONJ
ajst-32496	43	24	maintaining	maintain	VERB
ajst-32496	43	25	molecular	molecular	ADJ
ajst-32496	43	26	integrity	integrity	NOUN
ajst-32496	43	27	throughout	throughout	ADP
ajst-32496	43	28	the	the	DET
ajst-32496	43	29	synthesis	synthesis	NOUN
ajst-32496	43	30	.	.	PUNCT
ajst-32496	44	1	figure	figure	NOUN
ajst-32496	44	2	2	2	NUM
ajst-32496	44	3	.	.	PUNCT
ajst-32496	45	1	the	the	DET
ajst-32496	45	2	pathway	pathway	NOUN
ajst-32496	45	3	of	of	ADP
ajst-32496	45	4	sulphanilamide	sulphanilamide	ADJ
ajst-32496	45	5	synthesis	synthesis	NOUN
ajst-32496	45	6	2.2	2.2	NUM
ajst-32496	45	7	limitations	limitation	NOUN
ajst-32496	45	8	of	of	ADP
ajst-32496	45	9	the	the	DET
ajst-32496	45	10	traditional	traditional	ADJ
ajst-32496	45	11	method	method	NOUN
ajst-32496	45	12	while	while	SCONJ
ajst-32496	45	13	the	the	DET
ajst-32496	45	14	traditional	traditional	ADJ
ajst-32496	45	15	way	way	NOUN
ajst-32496	45	16	needs	need	VERB
ajst-32496	45	17	four	four	NUM
ajst-32496	45	18	steps	step	NOUN
ajst-32496	45	19	of	of	ADP
ajst-32496	45	20	separating	separate	VERB
ajst-32496	45	21	acetylation	acetylation	NOUN
ajst-32496	45	22	,	,	PUNCT
ajst-32496	45	23	chlorsulfonation	chlorsulfonation	NOUN
ajst-32496	45	24	,	,	PUNCT
ajst-32496	45	25	ammonolysis	ammonolysis	NOUN
ajst-32496	45	26	,	,	PUNCT
ajst-32496	45	27	and	and	CCONJ
ajst-32496	45	28	hydrolysis	hydrolysis	NOUN
ajst-32496	45	29	during	during	ADP
ajst-32496	45	30	the	the	DET
ajst-32496	45	31	synthesis	synthesis	NOUN
ajst-32496	45	32	,	,	PUNCT
ajst-32496	45	33	which	which	PRON
ajst-32496	45	34	is	be	AUX
ajst-32496	45	35	quite	quite	ADV
ajst-32496	45	36	cockamamie	cockamamie	ADJ
ajst-32496	45	37	and	and	CCONJ
ajst-32496	45	38	needs	need	VERB
ajst-32496	45	39	a	a	DET
ajst-32496	45	40	long	long	ADJ
ajst-32496	45	41	time	time	NOUN
ajst-32496	45	42	to	to	PART
ajst-32496	45	43	complete	complete	VERB
ajst-32496	45	44	the	the	DET
ajst-32496	45	45	synthesis	synthesis	NOUN
ajst-32496	45	46	,	,	PUNCT
ajst-32496	45	47	for	for	ADP
ajst-32496	45	48	all	all	DET
ajst-32496	45	49	products	product	NOUN
ajst-32496	45	50	of	of	ADP
ajst-32496	45	51	each	each	DET
ajst-32496	45	52	step	step	NOUN
ajst-32496	45	53	,	,	PUNCT
ajst-32496	45	54	there	there	PRON
ajst-32496	45	55	is	be	VERB
ajst-32496	45	56	at	at	ADV
ajst-32496	45	57	least	least	ADJ
ajst-32496	45	58	one	one	NUM
ajst-32496	45	59	hydrophilic	hydrophilic	ADJ
ajst-32496	45	60	group	group	NOUN
ajst-32496	45	61	,	,	PUNCT
ajst-32496	45	62	which	which	PRON
ajst-32496	45	63	allows	allow	VERB
ajst-32496	45	64	them	they	PRON
ajst-32496	45	65	to	to	PART
ajst-32496	45	66	dissolve	dissolve	VERB
ajst-32496	45	67	in	in	ADP
ajst-32496	45	68	water	water	NOUN
ajst-32496	45	69	,	,	PUNCT
ajst-32496	45	70	resulting	result	VERB
ajst-32496	45	71	in	in	ADP
ajst-32496	45	72	product	product	NOUN
ajst-32496	45	73	loss	loss	NOUN
ajst-32496	45	74	in	in	ADP
ajst-32496	45	75	the	the	DET
ajst-32496	45	76	filtrate	filtrate	NOUN
ajst-32496	45	77	.	.	PUNCT
ajst-32496	46	1	additionally	additionally	ADV
ajst-32496	46	2	,	,	PUNCT
ajst-32496	46	3	during	during	ADP
ajst-32496	46	4	the	the	DET
ajst-32496	46	5	synthesis	synthesis	NOUN
ajst-32496	46	6	,	,	PUNCT
ajst-32496	46	7	many	many	ADJ
ajst-32496	46	8	by	by	ADP
ajst-32496	46	9	-	-	PUNCT
ajst-32496	46	10	products	product	NOUN
ajst-32496	46	11	,	,	PUNCT
ajst-32496	46	12	similar	similar	ADJ
ajst-32496	46	13	to	to	ADP
ajst-32496	46	14	those	those	PRON
ajst-32496	46	15	in	in	ADP
ajst-32496	46	16	the	the	DET
ajst-32496	46	17	sulfonation	sulfonation	NOUN
ajst-32496	46	18	reaction	reaction	NOUN
ajst-32496	46	19	,	,	PUNCT
ajst-32496	46	20	can	can	AUX
ajst-32496	46	21	occur	occur	VERB
ajst-32496	46	22	.	.	PUNCT
ajst-32496	47	1	the	the	DET
ajst-32496	47	2	benzene	benzene	NOUN
ajst-32496	47	3	ring	ring	NOUN
ajst-32496	47	4	may	may	AUX
ajst-32496	47	5	be	be	AUX
ajst-32496	47	6	substituted	substitute	VERB
ajst-32496	47	7	at	at	ADP
ajst-32496	47	8	the	the	DET
ajst-32496	47	9	ortho	ortho	PROPN
ajst-32496	47	10	and	and	CCONJ
ajst-32496	47	11	meta	meta	ADJ
ajst-32496	47	12	positions	position	NOUN
ajst-32496	47	13	,	,	PUNCT
ajst-32496	47	14	producing	produce	VERB
ajst-32496	47	15	a	a	DET
ajst-32496	47	16	variety	variety	NOUN
ajst-32496	47	17	of	of	ADP
ajst-32496	47	18	by	by	ADP
ajst-32496	47	19	-	-	PUNCT
ajst-32496	47	20	products	product	NOUN
ajst-32496	47	21	that	that	PRON
ajst-32496	47	22	increase	increase	VERB
ajst-32496	47	23	the	the	DET
ajst-32496	47	24	difficulty	difficulty	NOUN
ajst-32496	47	25	of	of	ADP
ajst-32496	47	26	separation	separation	NOUN
ajst-32496	47	27	and	and	CCONJ
ajst-32496	47	28	purification	purification	NOUN
ajst-32496	47	29	.	.	PUNCT
ajst-32496	48	1	moreover	moreover	ADV
ajst-32496	48	2	,	,	PUNCT
ajst-32496	48	3	nitration	nitration	NOUN
ajst-32496	48	4	,	,	PUNCT
ajst-32496	48	5	sulfonation	sulfonation	NOUN
ajst-32496	48	6	,	,	PUNCT
ajst-32496	48	7	and	and	CCONJ
ajst-32496	48	8	other	other	ADJ
ajst-32496	48	9	steps	step	NOUN
ajst-32496	48	10	typically	typically	ADV
ajst-32496	48	11	require	require	VERB
ajst-32496	48	12	high	high	ADJ
ajst-32496	48	13	temperatures	temperature	NOUN
ajst-32496	48	14	(	(	PUNCT
ajst-32496	48	15	100	100	NUM
ajst-32496	48	16	-	-	PUNCT
ajst-32496	48	17	200	200	NUM
ajst-32496	48	18	℃	℃	PROPN
ajst-32496	48	19	)	)	PUNCT
ajst-32496	48	20	or	or	CCONJ
ajst-32496	48	21	a	a	DET
ajst-32496	48	22	strong	strong	ADJ
ajst-32496	48	23	amount	amount	NOUN
ajst-32496	48	24	of	of	ADP
ajst-32496	48	25	energy	energy	NOUN
ajst-32496	48	26	.	.	PUNCT
ajst-32496	49	1	some	some	DET
ajst-32496	49	2	reactions	reaction	NOUN
ajst-32496	49	3	require	require	VERB
ajst-32496	49	4	control	control	NOUN
ajst-32496	49	5	in	in	ADP
ajst-32496	49	6	an	an	DET
ajst-32496	49	7	oxygen	oxygen	NOUN
ajst-32496	49	8	-	-	PUNCT
ajst-32496	49	9	free	free	ADJ
ajst-32496	49	10	and	and	CCONJ
ajst-32496	49	11	anhydrous	anhydrous	ADJ
ajst-32496	49	12	environment	environment	NOUN
ajst-32496	49	13	.	.	PUNCT
ajst-32496	50	1	another	another	DET
ajst-32496	50	2	disadvantage	disadvantage	NOUN
ajst-32496	50	3	of	of	ADP
ajst-32496	50	4	using	use	VERB
ajst-32496	50	5	the	the	DET
ajst-32496	50	6	traditional	traditional	ADJ
ajst-32496	50	7	method	method	NOUN
ajst-32496	50	8	is	be	AUX
ajst-32496	50	9	the	the	DET
ajst-32496	50	10	low	low	ADJ
ajst-32496	50	11	theoretical	theoretical	ADJ
ajst-32496	50	12	atomic	atomic	ADJ
ajst-32496	50	13	economy	economy	NOUN
ajst-32496	50	14	of	of	ADP
ajst-32496	50	15	the	the	DET
ajst-32496	50	16	reagent	reagent	NOUN
ajst-32496	50	17	—	—	PUNCT
ajst-32496	50	18	a	a	DET
ajst-32496	50	19	larger	large	ADJ
ajst-32496	50	20	number	number	NOUN
ajst-32496	50	21	of	of	ADP
ajst-32496	50	22	atoms	atom	NOUN
ajst-32496	50	23	are	be	AUX
ajst-32496	50	24	wasted	waste	VERB
ajst-32496	50	25	in	in	ADP
ajst-32496	50	26	the	the	DET
ajst-32496	50	27	form	form	NOUN
ajst-32496	50	28	of	of	ADP
ajst-32496	50	29	the	the	DET
ajst-32496	50	30	by	by	NOUN
ajst-32496	50	31	-	-	PUNCT
ajst-32496	50	32	product	product	NOUN
ajst-32496	50	33	.	.	PUNCT
ajst-32496	51	1	for	for	ADP
ajst-32496	51	2	example	example	NOUN
ajst-32496	51	3	,	,	PUNCT
ajst-32496	51	4	only	only	ADV
ajst-32496	51	5	a	a	DET
ajst-32496	51	6	portion	portion	NOUN
ajst-32496	51	7	of	of	ADP
ajst-32496	51	8	the	the	DET
ajst-32496	51	9	sulfur	sulfur	NOUN
ajst-32496	51	10	element	element	NOUN
ajst-32496	51	11	in	in	ADP
ajst-32496	51	12	the	the	DET
ajst-32496	51	13	sulfuronation	sulfuronation	NOUN
ajst-32496	51	14	reagent	reagent	NOUN
ajst-32496	51	15	is	be	AUX
ajst-32496	51	16	incorporated	incorporate	VERB
ajst-32496	51	17	into	into	ADP
ajst-32496	51	18	the	the	DET
ajst-32496	51	19	target	target	NOUN
ajst-32496	51	20	product	product	NOUN
ajst-32496	51	21	,	,	PUNCT
ajst-32496	51	22	while	while	SCONJ
ajst-32496	51	23	the	the	DET
ajst-32496	51	24	remainder	remainder	NOUN
ajst-32496	51	25	is	be	AUX
ajst-32496	51	26	discharged	discharge	VERB
ajst-32496	51	27	as	as	ADP
ajst-32496	51	28	waste	waste	NOUN
ajst-32496	51	29	acid	acid	NOUN
ajst-32496	51	30	.	.	PUNCT
ajst-32496	52	1	hence	hence	ADV
ajst-32496	52	2	the	the	DET
ajst-32496	52	3	139	139	NUM
ajst-32496	52	4	theoretical	theoretical	ADJ
ajst-32496	52	5	atomic	atomic	ADJ
ajst-32496	52	6	economy	economy	NOUN
ajst-32496	52	7	is	be	AUX
ajst-32496	52	8	about	about	ADV
ajst-32496	52	9	0.504	0.504	NUM
ajst-32496	52	10	(	(	PUNCT
ajst-32496	52	11	tae	tae	NOUN
ajst-32496	52	12	=	=	SYM
ajst-32496	52	13	=	=	PROPN
ajst-32496	52	14	.	.	PUNCT
ajst-32496	53	1	=	=	PUNCT
ajst-32496	53	2	0.503	0.503	NUM
ajst-32496	53	3	)	)	PUNCT
ajst-32496	53	4	.	.	PUNCT
ajst-32496	54	1	the	the	DET
ajst-32496	54	2	reaction	reaction	NOUN
ajst-32496	54	3	does	do	AUX
ajst-32496	54	4	not	not	PART
ajst-32496	54	5	meet	meet	VERB
ajst-32496	54	6	the	the	DET
ajst-32496	54	7	requirements	requirement	NOUN
ajst-32496	54	8	of	of	ADP
ajst-32496	54	9	atom	atom	NOUN
ajst-32496	54	10	economy	economy	NOUN
ajst-32496	54	11	and	and	CCONJ
ajst-32496	54	12	sustainable	sustainable	ADJ
ajst-32496	54	13	development	development	NOUN
ajst-32496	54	14	.	.	PUNCT
ajst-32496	55	1	figure	figure	NOUN
ajst-32496	55	2	3	3	NUM
ajst-32496	55	3	.	.	PUNCT
ajst-32496	56	1	last	last	ADJ
ajst-32496	56	2	two	two	NUM
ajst-32496	56	3	steps	step	NOUN
ajst-32496	56	4	of	of	ADP
ajst-32496	56	5	sulphanilamide	sulphanilamide	ADJ
ajst-32496	56	6	synthesis	synthesis	NOUN
ajst-32496	56	7	in	in	ADP
ajst-32496	56	8	each	each	DET
ajst-32496	56	9	step	step	NOUN
ajst-32496	56	10	,	,	PUNCT
ajst-32496	56	11	numerous	numerous	ADJ
ajst-32496	56	12	details	detail	NOUN
ajst-32496	56	13	must	must	AUX
ajst-32496	56	14	be	be	AUX
ajst-32496	56	15	addressed	address	VERB
ajst-32496	56	16	to	to	PART
ajst-32496	56	17	increase	increase	VERB
ajst-32496	56	18	yield	yield	NOUN
ajst-32496	56	19	or	or	CCONJ
ajst-32496	56	20	reduce	reduce	VERB
ajst-32496	56	21	the	the	DET
ajst-32496	56	22	difficulty	difficulty	NOUN
ajst-32496	56	23	of	of	ADP
ajst-32496	56	24	separation	separation	NOUN
ajst-32496	56	25	.	.	PUNCT
ajst-32496	57	1	in	in	ADP
ajst-32496	57	2	step	step	NOUN
ajst-32496	57	3	01	01	NUM
ajst-32496	57	4	much	much	ADV
ajst-32496	57	5	excess	excess	ADJ
ajst-32496	57	6	chlorosulfonic	chlorosulfonic	ADJ
ajst-32496	57	7	acid	acid	NOUN
ajst-32496	57	8	added	add	VERB
ajst-32496	57	9	will	will	AUX
ajst-32496	57	10	lead	lead	VERB
ajst-32496	57	11	the	the	DET
ajst-32496	57	12	step	step	NOUN
ajst-32496	57	13	of	of	ADP
ajst-32496	57	14	washing	washing	NOUN
ajst-32496	57	15	sample	sample	NOUN
ajst-32496	57	16	to	to	PART
ajst-32496	57	17	change	change	VERB
ajst-32496	57	18	the	the	DET
ajst-32496	57	19	ph	ph	NOUN
ajst-32496	57	20	become	become	VERB
ajst-32496	57	21	more	more	ADV
ajst-32496	57	22	cockamamie	cockamamie	ADJ
ajst-32496	57	23	;	;	PUNCT
ajst-32496	57	24	in	in	ADP
ajst-32496	57	25	step	step	NOUN
ajst-32496	57	26	02	02	NUM
ajst-32496	57	27	the	the	DET
ajst-32496	57	28	reaction	reaction	NOUN
ajst-32496	57	29	has	have	VERB
ajst-32496	57	30	a	a	DET
ajst-32496	57	31	highly	highly	ADV
ajst-32496	57	32	require	require	NOUN
ajst-32496	57	33	of	of	ADP
ajst-32496	57	34	the	the	DET
ajst-32496	57	35	concentration	concentration	NOUN
ajst-32496	57	36	of	of	ADP
ajst-32496	57	37	the	the	DET
ajst-32496	57	38	solution	solution	NOUN
ajst-32496	57	39	of	of	ADP
ajst-32496	57	40	ammonia	ammonia	NOUN
ajst-32496	57	41	(	(	PUNCT
ajst-32496	57	42	at	at	ADP
ajst-32496	57	43	least	least	ADV
ajst-32496	57	44	25	25	NUM
ajst-32496	57	45	%	%	NOUN
ajst-32496	57	46	)	)	PUNCT
ajst-32496	57	47	ammonia	ammonia	NOUN
ajst-32496	57	48	to	to	PART
ajst-32496	57	49	make	make	VERB
ajst-32496	57	50	sure	sure	ADJ
ajst-32496	57	51	the	the	DET
ajst-32496	57	52	rate	rate	NOUN
ajst-32496	57	53	of	of	ADP
ajst-32496	57	54	the	the	DET
ajst-32496	57	55	reaction	reaction	NOUN
ajst-32496	57	56	not	not	PART
ajst-32496	57	57	be	be	AUX
ajst-32496	57	58	too	too	ADV
ajst-32496	57	59	low	low	ADJ
ajst-32496	57	60	;	;	PUNCT
ajst-32496	57	61	in	in	ADP
ajst-32496	57	62	step	step	NOUN
ajst-32496	57	63	03	03	NUM
ajst-32496	57	64	if	if	SCONJ
ajst-32496	57	65	the	the	DET
ajst-32496	57	66	acid	acid	NOUN
ajst-32496	57	67	is	be	AUX
ajst-32496	57	68	excess	excess	ADJ
ajst-32496	57	69	too	too	ADV
ajst-32496	57	70	much	much	ADJ
ajst-32496	57	71	or	or	CCONJ
ajst-32496	57	72	the	the	DET
ajst-32496	57	73	concentration	concentration	NOUN
ajst-32496	57	74	of	of	ADP
ajst-32496	57	75	the	the	DET
ajst-32496	57	76	base	base	NOUN
ajst-32496	57	77	is	be	AUX
ajst-32496	57	78	too	too	ADV
ajst-32496	57	79	low	low	ADJ
ajst-32496	57	80	too	too	ADV
ajst-32496	57	81	much	much	ADJ
ajst-32496	57	82	water	water	NOUN
ajst-32496	57	83	will	will	AUX
ajst-32496	57	84	be	be	AUX
ajst-32496	57	85	remained	remain	VERB
ajst-32496	57	86	in	in	ADP
ajst-32496	57	87	the	the	DET
ajst-32496	57	88	container	container	NOUN
ajst-32496	57	89	which	which	PRON
ajst-32496	57	90	increase	increase	VERB
ajst-32496	57	91	the	the	DET
ajst-32496	57	92	difficulty	difficulty	NOUN
ajst-32496	57	93	of	of	ADP
ajst-32496	57	94	crystallizing	crystallize	VERB
ajst-32496	57	95	(	(	PUNCT
ajst-32496	57	96	even	even	ADV
ajst-32496	57	97	need	need	VERB
ajst-32496	57	98	an	an	DET
ajst-32496	57	99	additional	additional	ADJ
ajst-32496	57	100	step	step	NOUN
ajst-32496	57	101	,	,	PUNCT
ajst-32496	57	102	rotary	rotary	ADJ
ajst-32496	57	103	evaporation	evaporation	NOUN
ajst-32496	57	104	,	,	PUNCT
ajst-32496	57	105	before	before	ADP
ajst-32496	57	106	sucking	suck	VERB
ajst-32496	57	107	filtration	filtration	NOUN
ajst-32496	57	108	)	)	PUNCT
ajst-32496	57	109	.	.	PUNCT
ajst-32496	58	1	moreover	moreover	ADV
ajst-32496	58	2	,	,	PUNCT
ajst-32496	58	3	between	between	ADP
ajst-32496	58	4	steps	step	NOUN
ajst-32496	58	5	,	,	PUNCT
ajst-32496	58	6	if	if	SCONJ
ajst-32496	58	7	the	the	DET
ajst-32496	58	8	sample	sample	NOUN
ajst-32496	58	9	of	of	ADP
ajst-32496	58	10	product	product	NOUN
ajst-32496	58	11	is	be	AUX
ajst-32496	58	12	not	not	PART
ajst-32496	58	13	completely	completely	ADV
ajst-32496	58	14	dry	dry	ADJ
ajst-32496	58	15	,	,	PUNCT
ajst-32496	58	16	it	it	PRON
ajst-32496	58	17	may	may	AUX
ajst-32496	58	18	stick	stick	VERB
ajst-32496	58	19	to	to	ADP
ajst-32496	58	20	the	the	DET
ajst-32496	58	21	inner	inner	ADJ
ajst-32496	58	22	wall	wall	NOUN
ajst-32496	58	23	of	of	ADP
ajst-32496	58	24	the	the	DET
ajst-32496	58	25	sample	sample	NOUN
ajst-32496	58	26	bottle	bottle	NOUN
ajst-32496	58	27	,	,	PUNCT
ajst-32496	58	28	resulting	result	VERB
ajst-32496	58	29	in	in	ADP
ajst-32496	58	30	unnecessary	unnecessary	ADJ
ajst-32496	58	31	material	material	NOUN
ajst-32496	58	32	waste	waste	NOUN
ajst-32496	58	33	.	.	PUNCT
ajst-32496	59	1	furthermore	furthermore	ADV
ajst-32496	59	2	,	,	PUNCT
ajst-32496	59	3	the	the	DET
ajst-32496	59	4	sample	sample	NOUN
ajst-32496	59	5	experiences	experience	VERB
ajst-32496	59	6	3	3	NUM
ajst-32496	59	7	times	time	NOUN
ajst-32496	59	8	of	of	ADP
ajst-32496	59	9	sucking	suck	VERB
ajst-32496	59	10	filtration	filtration	NOUN
ajst-32496	59	11	,	,	PUNCT
ajst-32496	59	12	and	and	CCONJ
ajst-32496	59	13	some	some	DET
ajst-32496	59	14	products	product	NOUN
ajst-32496	59	15	are	be	AUX
ajst-32496	59	16	lost	lose	VERB
ajst-32496	59	17	in	in	ADP
ajst-32496	59	18	the	the	DET
ajst-32496	59	19	filtrate	filtrate	NOUN
ajst-32496	59	20	.	.	PUNCT
ajst-32496	60	1	after	after	ADP
ajst-32496	60	2	completing	complete	VERB
ajst-32496	60	3	several	several	ADJ
ajst-32496	60	4	sets	set	NOUN
ajst-32496	60	5	of	of	ADP
ajst-32496	60	6	experiments	experiment	NOUN
ajst-32496	60	7	,	,	PUNCT
ajst-32496	60	8	the	the	DET
ajst-32496	60	9	yield	yield	NOUN
ajst-32496	60	10	of	of	ADP
ajst-32496	60	11	the	the	DET
ajst-32496	60	12	product	product	NOUN
ajst-32496	60	13	is	be	AUX
ajst-32496	60	14	presented	present	VERB
ajst-32496	60	15	in	in	ADP
ajst-32496	60	16	table	table	NOUN
ajst-32496	60	17	1	1	NUM
ajst-32496	60	18	below	below	ADV
ajst-32496	60	19	.	.	PUNCT
ajst-32496	61	1	due	due	ADP
ajst-32496	61	2	to	to	ADP
ajst-32496	61	3	the	the	DET
ajst-32496	61	4	experimental	experimental	ADJ
ajst-32496	61	5	conditions	condition	NOUN
ajst-32496	61	6	(	(	PUNCT
ajst-32496	61	7	the	the	DET
ajst-32496	61	8	air	air	NOUN
ajst-32496	61	9	pressure	pressure	NOUN
ajst-32496	61	10	is	be	AUX
ajst-32496	61	11	barely	barely	ADV
ajst-32496	61	12	able	able	ADJ
ajst-32496	61	13	to	to	PART
ajst-32496	61	14	reach	reach	VERB
ajst-32496	61	15	the	the	DET
ajst-32496	61	16	standard	standard	NOUN
ajst-32496	61	17	,	,	PUNCT
ajst-32496	61	18	which	which	PRON
ajst-32496	61	19	causes	cause	VERB
ajst-32496	61	20	a	a	DET
ajst-32496	61	21	difference	difference	NOUN
ajst-32496	61	22	in	in	ADP
ajst-32496	61	23	solubility	solubility	NOUN
ajst-32496	61	24	for	for	ADP
ajst-32496	61	25	the	the	DET
ajst-32496	61	26	product	product	NOUN
ajst-32496	61	27	)	)	PUNCT
ajst-32496	61	28	,	,	PUNCT
ajst-32496	61	29	it	it	PRON
ajst-32496	61	30	is	be	AUX
ajst-32496	61	31	not	not	PART
ajst-32496	61	32	entirely	entirely	ADV
ajst-32496	61	33	the	the	DET
ajst-32496	61	34	same	same	ADJ
ajst-32496	61	35	.	.	PUNCT
ajst-32496	62	1	hence	hence	ADV
ajst-32496	62	2	,	,	PUNCT
ajst-32496	62	3	the	the	DET
ajst-32496	62	4	extent	extent	NOUN
ajst-32496	62	5	of	of	ADP
ajst-32496	62	6	product	product	NOUN
ajst-32496	62	7	loss	loss	NOUN
ajst-32496	62	8	during	during	ADP
ajst-32496	62	9	filtration	filtration	NOUN
ajst-32496	62	10	varies	varie	NOUN
ajst-32496	62	11	.	.	PUNCT
ajst-32496	63	1	the	the	DET
ajst-32496	63	2	yield	yield	NOUN
ajst-32496	63	3	in	in	ADP
ajst-32496	63	4	most	most	ADJ
ajst-32496	63	5	groups	group	NOUN
ajst-32496	63	6	is	be	AUX
ajst-32496	63	7	too	too	ADV
ajst-32496	63	8	low	low	ADJ
ajst-32496	63	9	,	,	PUNCT
ajst-32496	63	10	as	as	SCONJ
ajst-32496	63	11	many	many	ADJ
ajst-32496	63	12	reagents	reagent	NOUN
ajst-32496	63	13	are	be	AUX
ajst-32496	63	14	wasted	waste	VERB
ajst-32496	63	15	during	during	ADP
ajst-32496	63	16	transportation	transportation	NOUN
ajst-32496	63	17	,	,	PUNCT
ajst-32496	63	18	separation	separation	NOUN
ajst-32496	63	19	,	,	PUNCT
ajst-32496	63	20	and	and	CCONJ
ajst-32496	63	21	other	other	ADJ
ajst-32496	63	22	processes	process	NOUN
ajst-32496	63	23	.	.	PUNCT
ajst-32496	64	1	hence	hence	ADV
ajst-32496	64	2	,	,	PUNCT
ajst-32496	64	3	the	the	DET
ajst-32496	64	4	yield	yield	NOUN
ajst-32496	64	5	is	be	AUX
ajst-32496	64	6	not	not	PART
ajst-32496	64	7	high	high	ADJ
ajst-32496	64	8	.	.	PUNCT
ajst-32496	65	1	(	(	PUNCT
ajst-32496	65	2	step	step	NOUN
ajst-32496	65	3	1	1	NUM
ajst-32496	65	4	)	)	PUNCT
ajst-32496	65	5	(	(	PUNCT
ajst-32496	65	6	step	step	NOUN
ajst-32496	65	7	2	2	NUM
ajst-32496	65	8	)	)	PUNCT
ajst-32496	65	9	(	(	PUNCT
ajst-32496	65	10	step	step	NOUN
ajst-32496	65	11	3	3	NUM
ajst-32496	65	12	)	)	PUNCT
ajst-32496	65	13	140	140	NUM
ajst-32496	65	14	table	table	NOUN
ajst-32496	65	15	1	1	NUM
ajst-32496	65	16	.	.	PUNCT
ajst-32496	65	17	yield	yield	NOUN
ajst-32496	65	18	of	of	ADP
ajst-32496	65	19	the	the	DET
ajst-32496	65	20	synthetic	synthetic	ADJ
ajst-32496	65	21	product	product	NOUN
ajst-32496	65	22	yield	yield	NOUN
ajst-32496	65	23	total	total	NOUN
ajst-32496	65	24	group1	group1	PROPN
ajst-32496	65	25	17.4	17.4	NUM
ajst-32496	65	26	%	%	NOUN
ajst-32496	65	27	group2	group2	NOUN
ajst-32496	65	28	14.5	14.5	NUM
ajst-32496	65	29	%	%	NOUN
ajst-32496	65	30	group	group	NOUN
ajst-32496	65	31	3	3	NUM
ajst-32496	65	32	34.3	34.3	NUM
ajst-32496	65	33	%	%	NOUN
ajst-32496	65	34	group	group	NOUN
ajst-32496	65	35	4	4	NUM
ajst-32496	65	36	9.3	9.3	NUM
ajst-32496	65	37	%	%	NOUN
ajst-32496	65	38	group	group	NOUN
ajst-32496	65	39	5	5	NUM
ajst-32496	65	40	32.8	32.8	NUM
ajst-32496	65	41	%	%	NOUN
ajst-32496	65	42	average	average	ADJ
ajst-32496	65	43	21.7	21.7	NUM
ajst-32496	65	44	%	%	NOUN
ajst-32496	65	45	3	3	NUM
ajst-32496	65	46	.	.	PUNCT
ajst-32496	65	47	research	research	NOUN
ajst-32496	65	48	on	on	ADP
ajst-32496	65	49	the	the	DET
ajst-32496	65	50	improvement	improvement	NOUN
ajst-32496	65	51	methods	method	NOUN
ajst-32496	65	52	of	of	ADP
ajst-32496	65	53	sulphanilamide	sulphanilamide	ADJ
ajst-32496	65	54	synthesis	synthesis	NOUN
ajst-32496	65	55	techniques	technique	NOUN
ajst-32496	65	56	based	base	VERB
ajst-32496	65	57	on	on	ADP
ajst-32496	65	58	our	our	PRON
ajst-32496	65	59	aforementioned	aforementioned	ADJ
ajst-32496	65	60	research	research	NOUN
ajst-32496	65	61	on	on	ADP
ajst-32496	65	62	the	the	DET
ajst-32496	65	63	classical	classical	ADJ
ajst-32496	65	64	synthesis	synthesis	NOUN
ajst-32496	65	65	process	process	NOUN
ajst-32496	65	66	of	of	ADP
ajst-32496	65	67	sulphanilamide	sulphanilamide	NOUN
ajst-32496	65	68	,	,	PUNCT
ajst-32496	65	69	we	we	PRON
ajst-32496	65	70	can	can	AUX
ajst-32496	65	71	conclude	conclude	VERB
ajst-32496	65	72	that	that	SCONJ
ajst-32496	65	73	although	although	SCONJ
ajst-32496	65	74	the	the	DET
ajst-32496	65	75	traditional	traditional	ADJ
ajst-32496	65	76	method	method	NOUN
ajst-32496	65	77	is	be	AUX
ajst-32496	65	78	feasible	feasible	ADJ
ajst-32496	65	79	.	.	PUNCT
ajst-32496	66	1	the	the	DET
ajst-32496	66	2	synthesis	synthesis	NOUN
ajst-32496	66	3	process	process	NOUN
ajst-32496	66	4	is	be	AUX
ajst-32496	66	5	wellestablished	wellestablishe	VERB
ajst-32496	66	6	;	;	PUNCT
ajst-32496	66	7	however	however	ADV
ajst-32496	66	8	,	,	PUNCT
ajst-32496	66	9	several	several	ADJ
ajst-32496	66	10	problems	problem	NOUN
ajst-32496	66	11	are	be	AUX
ajst-32496	66	12	associated	associate	VERB
ajst-32496	66	13	with	with	ADP
ajst-32496	66	14	the	the	DET
ajst-32496	66	15	traditional	traditional	ADJ
ajst-32496	66	16	sulphanilamide	sulphanilamide	ADJ
ajst-32496	66	17	synthesis	synthesis	NOUN
ajst-32496	66	18	method	method	NOUN
ajst-32496	66	19	,	,	PUNCT
ajst-32496	66	20	including	include	VERB
ajst-32496	66	21	a	a	DET
ajst-32496	66	22	relatively	relatively	ADV
ajst-32496	66	23	low	low	ADJ
ajst-32496	66	24	yield	yield	NOUN
ajst-32496	66	25	,	,	PUNCT
ajst-32496	66	26	high	high	ADJ
ajst-32496	66	27	energy	energy	NOUN
ajst-32496	66	28	consumption	consumption	NOUN
ajst-32496	66	29	in	in	ADP
ajst-32496	66	30	actual	actual	ADJ
ajst-32496	66	31	production	production	NOUN
ajst-32496	66	32	due	due	ADP
ajst-32496	66	33	to	to	ADP
ajst-32496	66	34	stringent	stringent	ADJ
ajst-32496	66	35	reaction	reaction	NOUN
ajst-32496	66	36	conditions	condition	NOUN
ajst-32496	66	37	,	,	PUNCT
ajst-32496	66	38	and	and	CCONJ
ajst-32496	66	39	the	the	DET
ajst-32496	66	40	presence	presence	NOUN
ajst-32496	66	41	of	of	ADP
ajst-32496	66	42	toxic	toxic	ADJ
ajst-32496	66	43	and	and	CCONJ
ajst-32496	66	44	harmful	harmful	ADJ
ajst-32496	66	45	substances	substance	NOUN
ajst-32496	66	46	during	during	ADP
ajst-32496	66	47	the	the	DET
ajst-32496	66	48	reaction	reaction	NOUN
ajst-32496	66	49	process	process	NOUN
ajst-32496	66	50	that	that	PRON
ajst-32496	66	51	cause	cause	VERB
ajst-32496	66	52	pollution	pollution	NOUN
ajst-32496	66	53	and	and	CCONJ
ajst-32496	66	54	are	be	AUX
ajst-32496	66	55	difficult	difficult	ADJ
ajst-32496	66	56	to	to	PART
ajst-32496	66	57	handle	handle	VERB
ajst-32496	66	58	.	.	PUNCT
ajst-32496	67	1	therefore	therefore	ADV
ajst-32496	67	2	,	,	PUNCT
ajst-32496	67	3	it	it	PRON
ajst-32496	67	4	is	be	AUX
ajst-32496	67	5	necessary	necessary	ADJ
ajst-32496	67	6	to	to	PART
ajst-32496	67	7	develop	develop	VERB
ajst-32496	67	8	some	some	DET
ajst-32496	67	9	methods	method	NOUN
ajst-32496	67	10	to	to	PART
ajst-32496	67	11	improve	improve	VERB
ajst-32496	67	12	the	the	DET
ajst-32496	67	13	synthesis	synthesis	NOUN
ajst-32496	67	14	process	process	NOUN
ajst-32496	67	15	.	.	PUNCT
ajst-32496	68	1	according	accord	VERB
ajst-32496	68	2	to	to	ADP
ajst-32496	68	3	our	our	PRON
ajst-32496	68	4	literature	literature	NOUN
ajst-32496	68	5	review	review	NOUN
ajst-32496	68	6	,	,	PUNCT
ajst-32496	68	7	numerous	numerous	ADJ
ajst-32496	68	8	modified	modified	ADJ
ajst-32496	68	9	pathways	pathway	NOUN
ajst-32496	68	10	exist	exist	VERB
ajst-32496	68	11	based	base	VERB
ajst-32496	68	12	on	on	ADP
ajst-32496	68	13	different	different	ADJ
ajst-32496	68	14	chemical	chemical	NOUN
ajst-32496	68	15	principles	principle	NOUN
ajst-32496	68	16	.	.	PUNCT
ajst-32496	69	1	the	the	DET
ajst-32496	69	2	improved	improve	VERB
ajst-32496	69	3	solutions	solution	NOUN
ajst-32496	69	4	that	that	PRON
ajst-32496	69	5	have	have	AUX
ajst-32496	69	6	been	be	AUX
ajst-32496	69	7	widely	widely	ADV
ajst-32496	69	8	adopted	adopt	VERB
ajst-32496	69	9	in	in	ADP
ajst-32496	69	10	recent	recent	ADJ
ajst-32496	69	11	years	year	NOUN
ajst-32496	69	12	can	can	AUX
ajst-32496	69	13	be	be	AUX
ajst-32496	69	14	classified	classify	VERB
ajst-32496	69	15	into	into	ADP
ajst-32496	69	16	three	three	NUM
ajst-32496	69	17	main	main	ADJ
ajst-32496	69	18	categories	category	NOUN
ajst-32496	69	19	based	base	VERB
ajst-32496	69	20	on	on	ADP
ajst-32496	69	21	their	their	PRON
ajst-32496	69	22	different	different	ADJ
ajst-32496	69	23	principles	principle	NOUN
ajst-32496	69	24	:	:	PUNCT
ajst-32496	70	1	1	1	X
ajst-32496	70	2	.	.	X
ajst-32496	70	3	continuous	continuous	ADJ
ajst-32496	70	4	flow	flow	NOUN
ajst-32496	70	5	technology	technology	NOUN
ajst-32496	70	6	(	(	PUNCT
ajst-32496	70	7	cft	cft	PROPN
ajst-32496	70	8	)	)	PUNCT
ajst-32496	70	9	,	,	PUNCT
ajst-32496	70	10	2	2	X
ajst-32496	70	11	.	.	PUNCT
ajst-32496	70	12	green	green	ADJ
ajst-32496	70	13	chemistry	chemistry	NOUN
ajst-32496	70	14	,	,	PUNCT
ajst-32496	70	15	3	3	NUM
ajst-32496	70	16	.	.	NOUN
ajst-32496	70	17	electrochemical	electrochemical	ADJ
ajst-32496	70	18	synthesis	synthesis	NOUN
ajst-32496	70	19	(	(	PUNCT
ajst-32496	70	20	ecs	ec	NOUN
ajst-32496	70	21	)	)	PUNCT
ajst-32496	70	22	.	.	PUNCT
ajst-32496	71	1	in	in	ADP
ajst-32496	71	2	the	the	DET
ajst-32496	71	3	following	follow	VERB
ajst-32496	71	4	article	article	NOUN
ajst-32496	71	5	,	,	PUNCT
ajst-32496	71	6	we	we	PRON
ajst-32496	71	7	selected	select	VERB
ajst-32496	71	8	some	some	DET
ajst-32496	71	9	typical	typical	ADJ
ajst-32496	71	10	cases	case	NOUN
ajst-32496	71	11	from	from	ADP
ajst-32496	71	12	each	each	DET
ajst-32496	71	13	category	category	NOUN
ajst-32496	71	14	.	.	PUNCT
ajst-32496	72	1	through	through	ADP
ajst-32496	72	2	the	the	DET
ajst-32496	72	3	lens	lens	NOUN
ajst-32496	72	4	of	of	ADP
ajst-32496	72	5	improved	improved	ADJ
ajst-32496	72	6	chemical	chemical	NOUN
ajst-32496	72	7	principles	principle	NOUN
ajst-32496	72	8	and	and	CCONJ
ajst-32496	72	9	data	datum	NOUN
ajst-32496	72	10	feedback	feedback	NOUN
ajst-32496	72	11	after	after	ADP
ajst-32496	72	12	production	production	NOUN
ajst-32496	72	13	,	,	PUNCT
ajst-32496	72	14	we	we	PRON
ajst-32496	72	15	examined	examine	VERB
ajst-32496	72	16	the	the	DET
ajst-32496	72	17	advantages	advantage	NOUN
ajst-32496	72	18	of	of	ADP
ajst-32496	72	19	these	these	DET
ajst-32496	72	20	cases	case	NOUN
ajst-32496	72	21	over	over	ADP
ajst-32496	72	22	traditional	traditional	ADJ
ajst-32496	72	23	synthesis	synthesis	NOUN
ajst-32496	72	24	methods	method	NOUN
ajst-32496	72	25	.	.	PUNCT
ajst-32496	73	1	3.1	3.1	NUM
ajst-32496	73	2	continuous	continuous	ADJ
ajst-32496	73	3	flow	flow	NOUN
ajst-32496	73	4	technology	technology	NOUN
ajst-32496	73	5	when	when	SCONJ
ajst-32496	73	6	synthesizing	synthesize	VERB
ajst-32496	73	7	using	use	VERB
ajst-32496	73	8	traditional	traditional	ADJ
ajst-32496	73	9	techniques	technique	NOUN
ajst-32496	73	10	,	,	PUNCT
ajst-32496	73	11	batch	batch	NOUN
ajst-32496	73	12	synthesis	synthesis	NOUN
ajst-32496	73	13	is	be	AUX
ajst-32496	73	14	usually	usually	ADV
ajst-32496	73	15	employed	employ	VERB
ajst-32496	73	16	.	.	PUNCT
ajst-32496	74	1	however	however	ADV
ajst-32496	74	2	,	,	PUNCT
ajst-32496	74	3	batch	batch	VERB
ajst-32496	74	4	synthesis	synthesis	NOUN
ajst-32496	74	5	technology	technology	NOUN
ajst-32496	74	6	has	have	VERB
ajst-32496	74	7	several	several	ADJ
ajst-32496	74	8	drawbacks	drawback	NOUN
ajst-32496	74	9	.	.	PUNCT
ajst-32496	75	1	for	for	ADP
ajst-32496	75	2	instance	instance	NOUN
ajst-32496	75	3	,	,	PUNCT
ajst-32496	75	4	the	the	DET
ajst-32496	75	5	mixing	mixing	NOUN
ajst-32496	75	6	of	of	ADP
ajst-32496	75	7	reagents	reagent	NOUN
ajst-32496	75	8	relies	rely	VERB
ajst-32496	75	9	on	on	ADP
ajst-32496	75	10	the	the	DET
ajst-32496	75	11	use	use	NOUN
ajst-32496	75	12	of	of	ADP
ajst-32496	75	13	a	a	DET
ajst-32496	75	14	stirring	stirring	ADJ
ajst-32496	75	15	device	device	NOUN
ajst-32496	75	16	.	.	PUNCT
ajst-32496	76	1	as	as	ADP
ajst-32496	76	2	the	the	DET
ajst-32496	76	3	scale	scale	NOUN
ajst-32496	76	4	increases	increase	NOUN
ajst-32496	76	5	,	,	PUNCT
ajst-32496	76	6	efficiency	efficiency	NOUN
ajst-32496	76	7	declines	decline	VERB
ajst-32496	76	8	,	,	PUNCT
ajst-32496	76	9	and	and	CCONJ
ajst-32496	76	10	this	this	PRON
ajst-32496	76	11	may	may	AUX
ajst-32496	76	12	also	also	ADV
ajst-32496	76	13	lead	lead	VERB
ajst-32496	76	14	to	to	ADP
ajst-32496	76	15	an	an	DET
ajst-32496	76	16	increase	increase	NOUN
ajst-32496	76	17	in	in	ADP
ajst-32496	76	18	by	by	ADP
ajst-32496	76	19	-	-	PUNCT
ajst-32496	76	20	products	product	NOUN
ajst-32496	76	21	.	.	PUNCT
ajst-32496	77	1	moreover	moreover	ADV
ajst-32496	77	2	,	,	PUNCT
ajst-32496	77	3	toxic	toxic	ADJ
ajst-32496	77	4	substances	substance	NOUN
ajst-32496	77	5	are	be	AUX
ajst-32496	77	6	involved	involve	VERB
ajst-32496	77	7	in	in	ADP
ajst-32496	77	8	the	the	DET
ajst-32496	77	9	reaction	reaction	NOUN
ajst-32496	77	10	,	,	PUNCT
ajst-32496	77	11	which	which	PRON
ajst-32496	77	12	may	may	AUX
ajst-32496	77	13	also	also	ADV
ajst-32496	77	14	pose	pose	VERB
ajst-32496	77	15	safety	safety	NOUN
ajst-32496	77	16	risks	risk	NOUN
ajst-32496	77	17	.	.	PUNCT
ajst-32496	78	1	that	that	PRON
ajst-32496	78	2	is	be	AUX
ajst-32496	78	3	why	why	SCONJ
ajst-32496	78	4	the	the	DET
ajst-32496	78	5	continuous	continuous	ADJ
ajst-32496	78	6	flow	flow	NOUN
ajst-32496	78	7	technology	technology	NOUN
ajst-32496	78	8	is	be	AUX
ajst-32496	78	9	needed	need	VERB
ajst-32496	78	10	to	to	PART
ajst-32496	78	11	optimise	optimise	VERB
ajst-32496	78	12	the	the	DET
ajst-32496	78	13	traditional	traditional	ADJ
ajst-32496	78	14	synthesising	synthesising	NOUN
ajst-32496	78	15	method.[5	method.[5	NOUN
ajst-32496	78	16	]	]	X
ajst-32496	78	17	3.1.1	3.1.1	NUM
ajst-32496	78	18	case	case	NOUN
ajst-32496	78	19	study	study	NOUN
ajst-32496	78	20	to	to	PART
ajst-32496	78	21	address	address	VERB
ajst-32496	78	22	the	the	DET
ajst-32496	78	23	problems	problem	NOUN
ajst-32496	78	24	associated	associate	VERB
ajst-32496	78	25	with	with	ADP
ajst-32496	78	26	traditional	traditional	ADJ
ajst-32496	78	27	synthesis	synthesis	NOUN
ajst-32496	78	28	methods	method	NOUN
ajst-32496	78	29	that	that	PRON
ajst-32496	78	30	arise	arise	VERB
ajst-32496	78	31	from	from	ADP
ajst-32496	78	32	the	the	DET
ajst-32496	78	33	increase	increase	NOUN
ajst-32496	78	34	in	in	ADP
ajst-32496	78	35	reaction	reaction	NOUN
ajst-32496	78	36	scale	scale	NOUN
ajst-32496	78	37	,	,	PUNCT
ajst-32496	78	38	which	which	PRON
ajst-32496	78	39	lead	lead	VERB
ajst-32496	78	40	to	to	ADP
ajst-32496	78	41	incomplete	incomplete	ADJ
ajst-32496	78	42	reactions	reaction	NOUN
ajst-32496	78	43	,	,	PUNCT
ajst-32496	78	44	unstable	unstable	ADJ
ajst-32496	78	45	intermediates	intermediate	NOUN
ajst-32496	78	46	,	,	PUNCT
ajst-32496	78	47	and	and	CCONJ
ajst-32496	78	48	difficulties	difficulty	NOUN
ajst-32496	78	49	in	in	ADP
ajst-32496	78	50	controlling	control	VERB
ajst-32496	78	51	heat	heat	NOUN
ajst-32496	78	52	release	release	NOUN
ajst-32496	78	53	,	,	PUNCT
ajst-32496	78	54	miao	miao	PROPN
ajst-32496	78	55	yu	yu	PROPN
ajst-32496	78	56	et	et	PROPN
ajst-32496	78	57	al	al	PROPN
ajst-32496	78	58	.	.	PROPN
ajst-32496	78	59	proposed	propose	VERB
ajst-32496	78	60	a	a	DET
ajst-32496	78	61	modified	modify	VERB
ajst-32496	78	62	continuous	continuous	ADJ
ajst-32496	78	63	process	process	NOUN
ajst-32496	78	64	in	in	ADP
ajst-32496	78	65	2019	2019	NUM
ajst-32496	78	66	.	.	PUNCT
ajst-32496	79	1	with	with	ADP
ajst-32496	79	2	this	this	DET
ajst-32496	79	3	method	method	NOUN
ajst-32496	79	4	,	,	PUNCT
ajst-32496	79	5	the	the	DET
ajst-32496	79	6	synthesis	synthesis	NOUN
ajst-32496	79	7	of	of	ADP
ajst-32496	79	8	5	5	NUM
ajst-32496	79	9	-	-	PUNCT
ajst-32496	79	10	bromo	bromo	NOUN
ajst-32496	79	11	-	-	PUNCT
ajst-32496	79	12	n-(tert	n-(tert	NOUN
ajst-32496	79	13	-	-	PUNCT
ajst-32496	79	14	butyl	butyl	NOUN
ajst-32496	79	15	)	)	PUNCT
ajst-32496	79	16	pyridine-3	pyridine-3	NUM
ajst-32496	79	17	-	-	NOUN
ajst-32496	79	18	sulfonamide	sulfonamide	NOUN
ajst-32496	79	19	can	can	AUX
ajst-32496	79	20	be	be	AUX
ajst-32496	79	21	successfully	successfully	ADV
ajst-32496	79	22	achieved	achieve	VERB
ajst-32496	79	23	.	.	PUNCT
ajst-32496	80	1	the	the	DET
ajst-32496	80	2	reaction	reaction	NOUN
ajst-32496	80	3	process	process	NOUN
ajst-32496	80	4	of	of	ADP
ajst-32496	80	5	this	this	DET
ajst-32496	80	6	technique	technique	NOUN
ajst-32496	80	7	mainly	mainly	ADV
ajst-32496	80	8	consists	consist	VERB
ajst-32496	80	9	of	of	ADP
ajst-32496	80	10	three	three	NUM
ajst-32496	80	11	steps	step	NOUN
ajst-32496	80	12	:	:	PUNCT
ajst-32496	80	13	1	1	X
ajst-32496	80	14	.	.	X
ajst-32496	80	15	using	use	VERB
ajst-32496	80	16	i	i	PROPN
ajst-32496	80	17	-	-	PUNCT
ajst-32496	80	18	prmgclꞏlicl	prmgclꞏlicl	PROPN
ajst-32496	80	19	and	and	CCONJ
ajst-32496	80	20	3,5	3,5	NUM
ajst-32496	80	21	-	-	NOUN
ajst-32496	80	22	dibromopyridine	dibromopyridine	NOUN
ajst-32496	80	23	to	to	PART
ajst-32496	80	24	react	react	VERB
ajst-32496	80	25	in	in	ADP
ajst-32496	80	26	thf	thf	NOUN
ajst-32496	80	27	to	to	PART
ajst-32496	80	28	form	form	VERB
ajst-32496	80	29	the	the	DET
ajst-32496	80	30	grignard	grignard	NOUN
ajst-32496	80	31	intermediate	intermediate	ADJ
ajst-32496	80	32	;	;	PUNCT
ajst-32496	80	33	2	2	X
ajst-32496	80	34	.	.	X
ajst-32496	80	35	sulfonation	sulfonation	NOUN
ajst-32496	80	36	:	:	PUNCT
ajst-32496	80	37	the	the	DET
ajst-32496	80	38	generated	generate	VERB
ajst-32496	80	39	grignard	grignard	ADJ
ajst-32496	80	40	reagent	reagent	NOUN
ajst-32496	80	41	reacts	react	NOUN
ajst-32496	80	42	with	with	ADP
ajst-32496	80	43	so₂cl₂	so₂cl₂	PROPN
ajst-32496	80	44	in	in	ADP
ajst-32496	80	45	dcm	dcm	PROPN
ajst-32496	80	46	to	to	PART
ajst-32496	80	47	form	form	VERB
ajst-32496	80	48	sulfonic	sulfonic	ADJ
ajst-32496	80	49	acid	acid	NOUN
ajst-32496	80	50	chloride	chloride	NOUN
ajst-32496	80	51	3	3	NUM
ajst-32496	80	52	.	.	PUNCT
ajst-32496	81	1	amination	amination	NOUN
ajst-32496	81	2	:	:	PUNCT
ajst-32496	82	1	the	the	DET
ajst-32496	82	2	sulfonic	sulfonic	ADJ
ajst-32496	82	3	acid	acid	NOUN
ajst-32496	82	4	chloride	chloride	NOUN
ajst-32496	82	5	solution	solution	NOUN
ajst-32496	82	6	is	be	AUX
ajst-32496	82	7	directly	directly	ADV
ajst-32496	82	8	introduced	introduce	VERB
ajst-32496	82	9	into	into	ADP
ajst-32496	82	10	the	the	DET
ajst-32496	82	11	dcm	dcm	PROPN
ajst-32496	82	12	solution	solution	NOUN
ajst-32496	82	13	containing	contain	VERB
ajst-32496	82	14	tertbutylamine	tertbutylamine	NOUN
ajst-32496	82	15	to	to	PART
ajst-32496	82	16	generate	generate	VERB
ajst-32496	82	17	the	the	DET
ajst-32496	82	18	target	target	NOUN
ajst-32496	82	19	sulphonamide[6	sulphonamide[6	NOUN
ajst-32496	82	20	]	]	PUNCT
ajst-32496	82	21	to	to	PART
ajst-32496	82	22	be	be	AUX
ajst-32496	82	23	specific	specific	ADJ
ajst-32496	82	24	,	,	PUNCT
ajst-32496	82	25	the	the	DET
ajst-32496	82	26	advantages	advantage	NOUN
ajst-32496	82	27	of	of	ADP
ajst-32496	82	28	this	this	DET
ajst-32496	82	29	technology	technology	NOUN
ajst-32496	82	30	can	can	AUX
ajst-32496	82	31	be	be	AUX
ajst-32496	82	32	summarised	summarise	VERB
ajst-32496	82	33	in	in	ADP
ajst-32496	82	34	the	the	DET
ajst-32496	82	35	following	follow	VERB
ajst-32496	82	36	aspects	aspect	NOUN
ajst-32496	82	37	.	.	PUNCT
ajst-32496	83	1	first	first	ADV
ajst-32496	83	2	,	,	PUNCT
ajst-32496	83	3	the	the	DET
ajst-32496	83	4	intrinsic	intrinsic	ADJ
ajst-32496	83	5	safety	safety	NOUN
ajst-32496	83	6	of	of	ADP
ajst-32496	83	7	it	it	PRON
ajst-32496	83	8	should	should	AUX
ajst-32496	83	9	be	be	AUX
ajst-32496	83	10	highlighted	highlight	VERB
ajst-32496	83	11	.	.	PUNCT
ajst-32496	84	1	the	the	DET
ajst-32496	84	2	traditional	traditional	ADJ
ajst-32496	84	3	reaction	reaction	NOUN
ajst-32496	84	4	takes	take	VERB
ajst-32496	84	5	place	place	NOUN
ajst-32496	84	6	in	in	ADP
ajst-32496	84	7	a	a	DET
ajst-32496	84	8	huge	huge	ADJ
ajst-32496	84	9	reaction	reaction	NOUN
ajst-32496	84	10	vessel	vessel	NOUN
ajst-32496	84	11	,	,	PUNCT
ajst-32496	84	12	where	where	SCONJ
ajst-32496	84	13	the	the	DET
ajst-32496	84	14	hazardous	hazardous	ADJ
ajst-32496	84	15	substances	substance	NOUN
ajst-32496	84	16	stored	store	VERB
ajst-32496	84	17	therein	therein	ADV
ajst-32496	84	18	are	be	AUX
ajst-32496	84	19	usually	usually	ADV
ajst-32496	84	20	in	in	ADP
ajst-32496	84	21	tons	ton	NOUN
ajst-32496	84	22	.	.	PUNCT
ajst-32496	85	1	if	if	SCONJ
ajst-32496	85	2	the	the	DET
ajst-32496	85	3	reaction	reaction	NOUN
ajst-32496	85	4	gets	get	VERB
ajst-32496	85	5	out	out	ADP
ajst-32496	85	6	of	of	ADP
ajst-32496	85	7	control	control	NOUN
ajst-32496	85	8	,	,	PUNCT
ajst-32496	85	9	it	it	PRON
ajst-32496	85	10	will	will	AUX
ajst-32496	85	11	lead	lead	VERB
ajst-32496	85	12	to	to	ADP
ajst-32496	85	13	serious	serious	ADJ
ajst-32496	85	14	consequences	consequence	NOUN
ajst-32496	85	15	.	.	PUNCT
ajst-32496	86	1	continuous	continuous	ADJ
ajst-32496	86	2	flow	flow	NOUN
ajst-32496	86	3	reactions	reaction	NOUN
ajst-32496	86	4	are	be	AUX
ajst-32496	86	5	carried	carry	VERB
ajst-32496	86	6	out	out	ADP
ajst-32496	86	7	in	in	ADP
ajst-32496	86	8	very	very	ADV
ajst-32496	86	9	small	small	ADJ
ajst-32496	86	10	pipes	pipe	NOUN
ajst-32496	86	11	.	.	PUNCT
ajst-32496	87	1	at	at	ADP
ajst-32496	87	2	any	any	DET
ajst-32496	87	3	time	time	NOUN
ajst-32496	87	4	,	,	PUNCT
ajst-32496	87	5	the	the	DET
ajst-32496	87	6	amount	amount	NOUN
ajst-32496	87	7	of	of	ADP
ajst-32496	87	8	hazardous	hazardous	ADJ
ajst-32496	87	9	substances	substance	NOUN
ajst-32496	87	10	in	in	ADP
ajst-32496	87	11	the	the	DET
ajst-32496	87	12	system	system	NOUN
ajst-32496	87	13	is	be	AUX
ajst-32496	87	14	very	very	ADV
ajst-32496	87	15	small	small	ADJ
ajst-32496	87	16	,	,	PUNCT
ajst-32496	87	17	making	make	VERB
ajst-32496	87	18	the	the	DET
ajst-32496	87	19	danger	danger	NOUN
ajst-32496	87	20	more	more	ADV
ajst-32496	87	21	controllable	controllable	ADJ
ajst-32496	87	22	.	.	PUNCT
ajst-32496	88	1	when	when	SCONJ
ajst-32496	88	2	a	a	DET
ajst-32496	88	3	strongly	strongly	ADV
ajst-32496	88	4	exothermic	exothermic	ADJ
ajst-32496	88	5	reaction	reaction	NOUN
ajst-32496	88	6	is	be	AUX
ajst-32496	88	7	initiated	initiate	VERB
ajst-32496	88	8	,	,	PUNCT
ajst-32496	88	9	the	the	DET
ajst-32496	88	10	surface	surface	NOUN
ajst-32496	88	11	area	area	NOUN
ajst-32496	88	12	of	of	ADP
ajst-32496	88	13	the	the	DET
ajst-32496	88	14	flow	flow	NOUN
ajst-32496	88	15	reactor	reactor	NOUN
ajst-32496	88	16	is	be	AUX
ajst-32496	88	17	larger	large	ADJ
ajst-32496	88	18	,	,	PUNCT
ajst-32496	88	19	which	which	PRON
ajst-32496	88	20	can	can	AUX
ajst-32496	88	21	prevent	prevent	VERB
ajst-32496	88	22	heat	heat	NOUN
ajst-32496	88	23	accumulation	accumulation	NOUN
ajst-32496	88	24	and	and	CCONJ
ajst-32496	88	25	the	the	DET
ajst-32496	88	26	occurrence	occurrence	NOUN
ajst-32496	88	27	of	of	ADP
ajst-32496	88	28	runaway	runaway	ADJ
ajst-32496	88	29	reactions	reaction	NOUN
ajst-32496	88	30	.	.	PUNCT
ajst-32496	89	1	141	141	NUM
ajst-32496	89	2	moreover	moreover	ADV
ajst-32496	89	3	,	,	PUNCT
ajst-32496	89	4	the	the	DET
ajst-32496	89	5	closed	closed	ADJ
ajst-32496	89	6	system	system	NOUN
ajst-32496	89	7	also	also	ADV
ajst-32496	89	8	enables	enable	VERB
ajst-32496	89	9	operators	operator	NOUN
ajst-32496	89	10	to	to	PART
ajst-32496	89	11	avoid	avoid	VERB
ajst-32496	89	12	exposure	exposure	NOUN
ajst-32496	89	13	to	to	ADP
ajst-32496	89	14	toxic	toxic	ADJ
ajst-32496	89	15	and	and	CCONJ
ajst-32496	89	16	harmful	harmful	ADJ
ajst-32496	89	17	volatile	volatile	ADJ
ajst-32496	89	18	reagents	reagent	NOUN
ajst-32496	89	19	while	while	SCONJ
ajst-32496	89	20	increasing	increase	VERB
ajst-32496	89	21	the	the	DET
ajst-32496	89	22	pressure	pressure	NOUN
ajst-32496	89	23	inside	inside	ADP
ajst-32496	89	24	the	the	DET
ajst-32496	89	25	container	container	NOUN
ajst-32496	89	26	,	,	PUNCT
ajst-32496	89	27	ensuring	ensure	VERB
ajst-32496	89	28	that	that	SCONJ
ajst-32496	89	29	the	the	DET
ajst-32496	89	30	reactants	reactant	NOUN
ajst-32496	89	31	remain	remain	VERB
ajst-32496	89	32	in	in	ADP
ajst-32496	89	33	a	a	DET
ajst-32496	89	34	liquid	liquid	ADJ
ajst-32496	89	35	state	state	NOUN
ajst-32496	89	36	throughout	throughout	ADP
ajst-32496	89	37	the	the	DET
ajst-32496	89	38	process	process	NOUN
ajst-32496	89	39	and	and	CCONJ
ajst-32496	89	40	thereby	thereby	ADV
ajst-32496	89	41	enhancing	enhance	VERB
ajst-32496	89	42	the	the	DET
ajst-32496	89	43	reaction	reaction	NOUN
ajst-32496	89	44	rate	rate	NOUN
ajst-32496	89	45	.	.	PUNCT
ajst-32496	90	1	second	second	ADJ
ajst-32496	90	2	,	,	PUNCT
ajst-32496	90	3	the	the	DET
ajst-32496	90	4	control	control	NOUN
ajst-32496	90	5	of	of	ADP
ajst-32496	90	6	the	the	DET
ajst-32496	90	7	entire	entire	ADJ
ajst-32496	90	8	reaction	reaction	NOUN
ajst-32496	90	9	has	have	AUX
ajst-32496	90	10	become	become	VERB
ajst-32496	90	11	more	more	ADV
ajst-32496	90	12	precise	precise	ADJ
ajst-32496	90	13	.	.	PUNCT
ajst-32496	91	1	the	the	DET
ajst-32496	91	2	duration	duration	NOUN
ajst-32496	91	3	that	that	PRON
ajst-32496	91	4	the	the	DET
ajst-32496	91	5	reactants	reactant	NOUN
ajst-32496	91	6	remain	remain	VERB
ajst-32496	91	7	in	in	ADP
ajst-32496	91	8	the	the	DET
ajst-32496	91	9	container	container	NOUN
ajst-32496	91	10	is	be	AUX
ajst-32496	91	11	precisely	precisely	ADV
ajst-32496	91	12	controlled	control	VERB
ajst-32496	91	13	,	,	PUNCT
ajst-32496	91	14	which	which	PRON
ajst-32496	91	15	is	be	AUX
ajst-32496	91	16	crucial	crucial	ADJ
ajst-32496	91	17	for	for	ADP
ajst-32496	91	18	unstable	unstable	ADJ
ajst-32496	91	19	intermediates	intermediate	NOUN
ajst-32496	91	20	.	.	PUNCT
ajst-32496	92	1	this	this	PRON
ajst-32496	92	2	ensures	ensure	VERB
ajst-32496	92	3	that	that	SCONJ
ajst-32496	92	4	they	they	PRON
ajst-32496	92	5	can	can	AUX
ajst-32496	92	6	continue	continue	VERB
ajst-32496	92	7	to	to	PART
ajst-32496	92	8	participate	participate	VERB
ajst-32496	92	9	in	in	ADP
ajst-32496	92	10	the	the	DET
ajst-32496	92	11	next	next	ADJ
ajst-32496	92	12	reaction	reaction	NOUN
ajst-32496	92	13	before	before	ADP
ajst-32496	92	14	decomposition	decomposition	NOUN
ajst-32496	92	15	,	,	PUNCT
ajst-32496	92	16	and	and	CCONJ
ajst-32496	92	17	the	the	DET
ajst-32496	92	18	temperature	temperature	NOUN
ajst-32496	92	19	and	and	CCONJ
ajst-32496	92	20	concentration	concentration	NOUN
ajst-32496	92	21	within	within	ADP
ajst-32496	92	22	the	the	DET
ajst-32496	92	23	entire	entire	ADJ
ajst-32496	92	24	system	system	NOUN
ajst-32496	92	25	are	be	AUX
ajst-32496	92	26	nearly	nearly	ADV
ajst-32496	92	27	uniform	uniform	ADJ
ajst-32496	92	28	,	,	PUNCT
ajst-32496	92	29	allowing	allow	VERB
ajst-32496	92	30	for	for	ADP
ajst-32496	92	31	real	real	ADJ
ajst-32496	92	32	-	-	PUNCT
ajst-32496	92	33	time	time	NOUN
ajst-32496	92	34	monitoring	monitoring	NOUN
ajst-32496	92	35	.	.	PUNCT
ajst-32496	93	1	third	third	ADJ
ajst-32496	93	2	,	,	PUNCT
ajst-32496	93	3	the	the	DET
ajst-32496	93	4	continuous	continuous	ADJ
ajst-32496	93	5	flow	flow	NOUN
ajst-32496	93	6	technology	technology	NOUN
ajst-32496	93	7	circumvents	circumvent	VERB
ajst-32496	93	8	the	the	DET
ajst-32496	93	9	problems	problem	NOUN
ajst-32496	93	10	that	that	PRON
ajst-32496	93	11	arise	arise	VERB
ajst-32496	93	12	in	in	ADP
ajst-32496	93	13	traditional	traditional	ADJ
ajst-32496	93	14	reaction	reaction	NOUN
ajst-32496	93	15	techniques	technique	NOUN
ajst-32496	93	16	,	,	PUNCT
ajst-32496	93	17	where	where	SCONJ
ajst-32496	93	18	an	an	DET
ajst-32496	93	19	increase	increase	NOUN
ajst-32496	93	20	in	in	ADP
ajst-32496	93	21	reaction	reaction	NOUN
ajst-32496	93	22	scale	scale	NOUN
ajst-32496	93	23	impacts	impact	VERB
ajst-32496	93	24	the	the	DET
ajst-32496	93	25	reaction	reaction	NOUN
ajst-32496	93	26	outcome	outcome	NOUN
ajst-32496	93	27	.	.	PUNCT
ajst-32496	94	1	the	the	DET
ajst-32496	94	2	cft	cft	NOUN
ajst-32496	94	3	involves	involve	VERB
ajst-32496	94	4	increasing	increase	VERB
ajst-32496	94	5	the	the	DET
ajst-32496	94	6	number	number	NOUN
ajst-32496	94	7	of	of	ADP
ajst-32496	94	8	reaction	reaction	NOUN
ajst-32496	94	9	units	unit	NOUN
ajst-32496	94	10	,	,	PUNCT
ajst-32496	94	11	ensuring	ensure	VERB
ajst-32496	94	12	that	that	SCONJ
ajst-32496	94	13	the	the	DET
ajst-32496	94	14	conditions	condition	NOUN
ajst-32496	94	15	in	in	ADP
ajst-32496	94	16	each	each	DET
ajst-32496	94	17	unit	unit	NOUN
ajst-32496	94	18	are	be	AUX
ajst-32496	94	19	identical	identical	ADJ
ajst-32496	94	20	to	to	ADP
ajst-32496	94	21	those	those	PRON
ajst-32496	94	22	established	establish	VERB
ajst-32496	94	23	in	in	ADP
ajst-32496	94	24	the	the	DET
ajst-32496	94	25	laboratory	laboratory	NOUN
ajst-32496	94	26	.	.	PUNCT
ajst-32496	95	1	3.1.2	3.1.2	NUM
ajst-32496	95	2	production	production	NOUN
ajst-32496	95	3	application	application	NOUN
ajst-32496	95	4	continuous	continuous	ADJ
ajst-32496	95	5	flow	flow	NOUN
ajst-32496	95	6	technology	technology	NOUN
ajst-32496	95	7	has	have	AUX
ajst-32496	95	8	currently	currently	ADV
ajst-32496	95	9	been	be	AUX
ajst-32496	95	10	applied	apply	VERB
ajst-32496	95	11	in	in	ADP
ajst-32496	95	12	production	production	NOUN
ajst-32496	95	13	,	,	PUNCT
ajst-32496	95	14	and	and	CCONJ
ajst-32496	95	15	its	its	PRON
ajst-32496	95	16	improved	improved	ADJ
ajst-32496	95	17	effects	effect	NOUN
ajst-32496	95	18	have	have	AUX
ajst-32496	95	19	been	be	AUX
ajst-32496	95	20	confirmed	confirm	VERB
ajst-32496	95	21	.	.	PUNCT
ajst-32496	96	1	the	the	DET
ajst-32496	96	2	‘	'	PUNCT
ajst-32496	96	3	2025	2025	NUM
ajst-32496	96	4	china	china	PROPN
ajst-32496	96	5	industrial	industrial	ADJ
ajst-32496	96	6	sulfanilamide	sulfanilamide	NOUN
ajst-32496	96	7	(	(	PUNCT
ajst-32496	96	8	sn	sn	NOUN
ajst-32496	96	9	)	)	PUNCT
ajst-32496	96	10	data	datum	NOUN
ajst-32496	96	11	monitoring	monitor	VERB
ajst-32496	96	12	research	research	NOUN
ajst-32496	96	13	report	report	NOUN
ajst-32496	96	14	’	'	PUNCT
ajst-32496	96	15	indicates	indicate	VERB
ajst-32496	96	16	that	that	SCONJ
ajst-32496	96	17	leading	lead	VERB
ajst-32496	96	18	chinese	chinese	ADJ
ajst-32496	96	19	pharmaceutical	pharmaceutical	ADJ
ajst-32496	96	20	companies	company	NOUN
ajst-32496	96	21	such	such	ADJ
ajst-32496	96	22	as	as	ADP
ajst-32496	96	23	lu'an	lu'an	NOUN
ajst-32496	96	24	pharmaceutical	pharmaceutical	NOUN
ajst-32496	96	25	and	and	CCONJ
ajst-32496	96	26	huabei	huabei	NOUN
ajst-32496	96	27	pharmaceutical	pharmaceutical	NOUN
ajst-32496	96	28	have	have	AUX
ajst-32496	96	29	successfully	successfully	ADV
ajst-32496	96	30	applied	apply	VERB
ajst-32496	96	31	micro	micro	ADJ
ajst-32496	96	32	-	-	ADJ
ajst-32496	96	33	reactor	reactor	ADJ
ajst-32496	96	34	technology	technology	NOUN
ajst-32496	96	35	on	on	ADP
ajst-32496	96	36	a	a	DET
ajst-32496	96	37	large	large	ADJ
ajst-32496	96	38	scale	scale	NOUN
ajst-32496	96	39	and	and	CCONJ
ajst-32496	96	40	achieved	achieve	VERB
ajst-32496	96	41	positive	positive	ADJ
ajst-32496	96	42	results	result	NOUN
ajst-32496	96	43	.	.	PUNCT
ajst-32496	97	1	the	the	DET
ajst-32496	97	2	traditional	traditional	ADJ
ajst-32496	97	3	synthesis	synthesis	NOUN
ajst-32496	97	4	of	of	ADP
ajst-32496	97	5	sulfonamides	sulfonamide	NOUN
ajst-32496	97	6	primarily	primarily	ADV
ajst-32496	97	7	employs	employ	VERB
ajst-32496	97	8	batch	batch	NOUN
ajst-32496	97	9	or	or	CCONJ
ajst-32496	97	10	continuous	continuous	ADJ
ajst-32496	97	11	reactions	reaction	NOUN
ajst-32496	97	12	.	.	PUNCT
ajst-32496	98	1	the	the	DET
ajst-32496	98	2	core	core	NOUN
ajst-32496	98	3	problem	problem	NOUN
ajst-32496	98	4	lies	lie	VERB
ajst-32496	98	5	in	in	ADP
ajst-32496	98	6	the	the	DET
ajst-32496	98	7	uncontrolled	uncontrolled	ADJ
ajst-32496	98	8	high	high	ADJ
ajst-32496	98	9	activity	activity	NOUN
ajst-32496	98	10	of	of	ADP
ajst-32496	98	11	intermediates	intermediate	NOUN
ajst-32496	98	12	and	and	CCONJ
ajst-32496	98	13	the	the	DET
ajst-32496	98	14	low	low	ADJ
ajst-32496	98	15	selectivity	selectivity	NOUN
ajst-32496	98	16	of	of	ADP
ajst-32496	98	17	the	the	DET
ajst-32496	98	18	reaction	reaction	NOUN
ajst-32496	98	19	.	.	PUNCT
ajst-32496	99	1	for	for	ADP
ajst-32496	99	2	instance	instance	NOUN
ajst-32496	99	3	,	,	PUNCT
ajst-32496	99	4	in	in	ADP
ajst-32496	99	5	the	the	DET
ajst-32496	99	6	key	key	ADJ
ajst-32496	99	7	chlorosulfonation	chlorosulfonation	NOUN
ajst-32496	99	8	step	step	NOUN
ajst-32496	99	9	,	,	PUNCT
ajst-32496	99	10	the	the	DET
ajst-32496	99	11	reaction	reaction	NOUN
ajst-32496	99	12	between	between	ADP
ajst-32496	99	13	p	p	NOUN
ajst-32496	99	14	-	-	PUNCT
ajst-32496	99	15	aminobenzene	aminobenzene	NOUN
ajst-32496	99	16	and	and	CCONJ
ajst-32496	99	17	chlorosulfonic	chlorosulfonic	ADJ
ajst-32496	99	18	acid	acid	NOUN
ajst-32496	99	19	is	be	AUX
ajst-32496	99	20	prone	prone	ADJ
ajst-32496	99	21	to	to	ADP
ajst-32496	99	22	generating	generate	VERB
ajst-32496	99	23	polysulfonated	polysulfonate	VERB
ajst-32496	99	24	by	by	ADP
ajst-32496	99	25	-	-	PUNCT
ajst-32496	99	26	products	product	NOUN
ajst-32496	99	27	due	due	ADJ
ajst-32496	99	28	to	to	ADP
ajst-32496	99	29	local	local	ADJ
ajst-32496	99	30	overheating	overheating	NOUN
ajst-32496	99	31	.	.	PUNCT
ajst-32496	100	1	after	after	ADP
ajst-32496	100	2	that	that	PRON
ajst-32496	100	3	,	,	PUNCT
ajst-32496	100	4	in	in	ADP
ajst-32496	100	5	the	the	DET
ajst-32496	100	6	subsequent	subsequent	ADJ
ajst-32496	100	7	amide	amide	NOUN
ajst-32496	100	8	formation	formation	NOUN
ajst-32496	100	9	reaction	reaction	NOUN
ajst-32496	100	10	,	,	PUNCT
ajst-32496	100	11	the	the	DET
ajst-32496	100	12	hydrolysis	hydrolysis	NOUN
ajst-32496	100	13	loss	loss	NOUN
ajst-32496	100	14	of	of	ADP
ajst-32496	100	15	the	the	DET
ajst-32496	100	16	sulfonyl	sulfonyl	NOUN
ajst-32496	100	17	chloride	chloride	NOUN
ajst-32496	100	18	intermediate	intermediate	ADJ
ajst-32496	100	19	further	far	ADV
ajst-32496	100	20	reduces	reduce	VERB
ajst-32496	100	21	the	the	DET
ajst-32496	100	22	industry	industry	NOUN
ajst-32496	100	23	average	average	ADJ
ajst-32496	100	24	yield	yield	NOUN
ajst-32496	100	25	,	,	PUNCT
ajst-32496	100	26	which	which	PRON
ajst-32496	100	27	has	have	AUX
ajst-32496	100	28	remained	remain	VERB
ajst-32496	100	29	at	at	ADP
ajst-32496	100	30	around	around	ADP
ajst-32496	100	31	50%-68	50%-68	NUM
ajst-32496	100	32	%	%	NOUN
ajst-32496	100	33	for	for	ADP
ajst-32496	100	34	a	a	DET
ajst-32496	100	35	long	long	ADJ
ajst-32496	100	36	time	time	NOUN
ajst-32496	100	37	.	.	PUNCT
ajst-32496	101	1	the	the	DET
ajst-32496	101	2	technological	technological	ADJ
ajst-32496	101	3	breakthroughs	breakthrough	NOUN
ajst-32496	101	4	of	of	ADP
ajst-32496	101	5	leading	lead	VERB
ajst-32496	101	6	enterprises	enterprise	NOUN
ajst-32496	101	7	are	be	AUX
ajst-32496	101	8	reflected	reflect	VERB
ajst-32496	101	9	in	in	ADP
ajst-32496	101	10	dual	dual	ADJ
ajst-32496	101	11	-	-	PUNCT
ajst-32496	101	12	temperature	temperature	NOUN
ajst-32496	101	13	zones	zone	NOUN
ajst-32496	101	14	,	,	PUNCT
ajst-32496	101	15	precise	precise	ADJ
ajst-32496	101	16	temperature	temperature	NOUN
ajst-32496	101	17	control	control	NOUN
ajst-32496	101	18	,	,	PUNCT
ajst-32496	101	19	and	and	CCONJ
ajst-32496	101	20	seamless	seamless	ADJ
ajst-32496	101	21	integration	integration	NOUN
ajst-32496	101	22	of	of	ADP
ajst-32496	101	23	continuous	continuous	ADJ
ajst-32496	101	24	flow	flow	NOUN
ajst-32496	101	25	.	.	PUNCT
ajst-32496	102	1	the	the	DET
ajst-32496	102	2	yield	yield	NOUN
ajst-32496	102	3	of	of	ADP
ajst-32496	102	4	core	core	NOUN
ajst-32496	102	5	products	product	NOUN
ajst-32496	102	6	has	have	AUX
ajst-32496	102	7	generally	generally	ADV
ajst-32496	102	8	exceeded	exceed	VERB
ajst-32496	102	9	95	95	NUM
ajst-32496	102	10	%	%	NOUN
ajst-32496	102	11	,	,	PUNCT
ajst-32496	102	12	directly	directly	ADV
ajst-32496	102	13	driving	drive	VERB
ajst-32496	102	14	the	the	DET
ajst-32496	102	15	average	average	ADJ
ajst-32496	102	16	industry	industry	NOUN
ajst-32496	102	17	yield	yield	NOUN
ajst-32496	102	18	in	in	ADP
ajst-32496	102	19	2023	2023	NUM
ajst-32496	102	20	to	to	PART
ajst-32496	102	21	rise	rise	VERB
ajst-32496	102	22	from	from	ADP
ajst-32496	102	23	78	78	NUM
ajst-32496	102	24	%	%	NOUN
ajst-32496	102	25	in	in	ADP
ajst-32496	102	26	2021	2021	NUM
ajst-32496	102	27	to	to	ADP
ajst-32496	102	28	92	92	NUM
ajst-32496	102	29	%	%	NOUN
ajst-32496	102	30	.	.	PUNCT
ajst-32496	103	1	traditional	traditional	ADJ
ajst-32496	103	2	batch	batch	NOUN
ajst-32496	103	3	reactors	reactor	NOUN
ajst-32496	103	4	rely	rely	VERB
ajst-32496	103	5	on	on	ADP
ajst-32496	103	6	external	external	ADJ
ajst-32496	103	7	heating	heating	NOUN
ajst-32496	103	8	to	to	PART
ajst-32496	103	9	maintain	maintain	VERB
ajst-32496	103	10	reaction	reaction	NOUN
ajst-32496	103	11	temperature	temperature	NOUN
ajst-32496	103	12	,	,	PUNCT
ajst-32496	103	13	and	and	CCONJ
ajst-32496	103	14	the	the	DET
ajst-32496	103	15	low	low	ADJ
ajst-32496	103	16	mixing	mix	VERB
ajst-32496	103	17	efficiency	efficiency	NOUN
ajst-32496	103	18	leads	lead	VERB
ajst-32496	103	19	to	to	ADP
ajst-32496	103	20	reaction	reaction	NOUN
ajst-32496	103	21	cycles	cycle	NOUN
ajst-32496	103	22	lasting	last	VERB
ajst-32496	103	23	8	8	NUM
ajst-32496	103	24	-	-	SYM
ajst-32496	103	25	12	12	NUM
ajst-32496	103	26	hours	hour	NOUN
ajst-32496	103	27	,	,	PUNCT
ajst-32496	103	28	with	with	ADP
ajst-32496	103	29	the	the	DET
ajst-32496	103	30	unit	unit	NOUN
ajst-32496	103	31	product	product	NOUN
ajst-32496	103	32	’s	’s	PART
ajst-32496	103	33	comprehensive	comprehensive	ADJ
ajst-32496	103	34	energy	energy	NOUN
ajst-32496	103	35	consumption	consumption	NOUN
ajst-32496	103	36	reaching	reach	VERB
ajst-32496	103	37	as	as	ADV
ajst-32496	103	38	high	high	ADJ
ajst-32496	103	39	as	as	ADP
ajst-32496	103	40	1.2	1.2	NUM
ajst-32496	103	41	tons	ton	NOUN
ajst-32496	103	42	per	per	ADP
ajst-32496	103	43	ton	ton	NOUN
ajst-32496	103	44	.	.	PUNCT
ajst-32496	104	1	the	the	DET
ajst-32496	104	2	high	high	ADJ
ajst-32496	104	3	specific	specific	ADJ
ajst-32496	104	4	surface	surface	NOUN
ajst-32496	104	5	area	area	NOUN
ajst-32496	104	6	advantage	advantage	NOUN
ajst-32496	104	7	of	of	ADP
ajst-32496	104	8	microreactors	microreactor	NOUN
ajst-32496	104	9	(	(	PUNCT
ajst-32496	104	10	up	up	ADP
ajst-32496	104	11	to	to	PART
ajst-32496	104	12	1000	1000	NUM
ajst-32496	104	13	times	time	NOUN
ajst-32496	104	14	that	that	PRON
ajst-32496	104	15	of	of	ADP
ajst-32496	104	16	traditional	traditional	ADJ
ajst-32496	104	17	reactors	reactor	NOUN
ajst-32496	104	18	)	)	PUNCT
ajst-32496	104	19	reconfigures	reconfigure	VERB
ajst-32496	104	20	the	the	DET
ajst-32496	104	21	heat	heat	NOUN
ajst-32496	104	22	transfer	transfer	NOUN
ajst-32496	104	23	path	path	NOUN
ajst-32496	104	24	:	:	PUNCT
ajst-32496	104	25	in	in	ADP
ajst-32496	104	26	the	the	DET
ajst-32496	104	27	production	production	NOUN
ajst-32496	104	28	of	of	ADP
ajst-32496	104	29	sulfamethoxazole	sulfamethoxazole	NOUN
ajst-32496	104	30	by	by	ADP
ajst-32496	104	31	lu'an	lu'an	PROPN
ajst-32496	104	32	pharmaceutical	pharmaceutical	PROPN
ajst-32496	104	33	,	,	PUNCT
ajst-32496	104	34	a	a	DET
ajst-32496	104	35	modular	modular	ADJ
ajst-32496	104	36	microchannel	microchannel	NOUN
ajst-32496	104	37	reactor	reactor	NOUN
ajst-32496	104	38	was	be	AUX
ajst-32496	104	39	adopted	adopt	VERB
ajst-32496	104	40	.	.	PUNCT
ajst-32496	105	1	through	through	ADP
ajst-32496	105	2	the	the	DET
ajst-32496	105	3	jacketed	jacket	VERB
ajst-32496	105	4	heat	heat	NOUN
ajst-32496	105	5	transfer	transfer	NOUN
ajst-32496	105	6	oil	oil	NOUN
ajst-32496	105	7	,	,	PUNCT
ajst-32496	105	8	the	the	DET
ajst-32496	105	9	heat	heat	NOUN
ajst-32496	105	10	released	release	VERB
ajst-32496	105	11	during	during	ADP
ajst-32496	105	12	the	the	DET
ajst-32496	105	13	reaction	reaction	NOUN
ajst-32496	105	14	was	be	AUX
ajst-32496	105	15	removed	remove	VERB
ajst-32496	105	16	in	in	ADP
ajst-32496	105	17	real	real	ADJ
ajst-32496	105	18	time	time	NOUN
ajst-32496	105	19	,	,	PUNCT
ajst-32496	105	20	allowing	allow	VERB
ajst-32496	105	21	the	the	DET
ajst-32496	105	22	optimal	optimal	ADJ
ajst-32496	105	23	reaction	reaction	NOUN
ajst-32496	105	24	temperature	temperature	NOUN
ajst-32496	105	25	of	of	ADP
ajst-32496	105	26	80	80	NUM
ajst-32496	105	27	°	°	NOUN
ajst-32496	105	28	c	c	NOUN
ajst-32496	105	29	to	to	PART
ajst-32496	105	30	be	be	AUX
ajst-32496	105	31	maintained	maintain	VERB
ajst-32496	105	32	without	without	ADP
ajst-32496	105	33	additional	additional	ADJ
ajst-32496	105	34	heating	heating	NOUN
ajst-32496	105	35	.	.	PUNCT
ajst-32496	106	1	the	the	DET
ajst-32496	106	2	reaction	reaction	NOUN
ajst-32496	106	3	time	time	NOUN
ajst-32496	106	4	per	per	ADP
ajst-32496	106	5	batch	batch	NOUN
ajst-32496	106	6	was	be	AUX
ajst-32496	106	7	reduced	reduce	VERB
ajst-32496	106	8	from	from	ADP
ajst-32496	106	9	12	12	NUM
ajst-32496	106	10	hours	hour	NOUN
ajst-32496	106	11	to	to	ADP
ajst-32496	106	12	30	30	NUM
ajst-32496	106	13	minutes	minute	NOUN
ajst-32496	106	14	,	,	PUNCT
ajst-32496	106	15	and	and	CCONJ
ajst-32496	106	16	the	the	DET
ajst-32496	106	17	heating	heating	NOUN
ajst-32496	106	18	energy	energy	NOUN
ajst-32496	106	19	consumption	consumption	NOUN
ajst-32496	106	20	was	be	AUX
ajst-32496	106	21	reduced	reduce	VERB
ajst-32496	106	22	by	by	ADP
ajst-32496	106	23	40%.[7	40%.[7	NUM
ajst-32496	106	24	]	]	PUNCT
ajst-32496	106	25	3.2	3.2	NUM
ajst-32496	106	26	green	green	ADJ
ajst-32496	106	27	chemistry	chemistry	NOUN
ajst-32496	106	28	3.2.1	3.2.1	NUM
ajst-32496	106	29	about	about	ADP
ajst-32496	106	30	green	green	ADJ
ajst-32496	106	31	chemistry	chemistry	NOUN
ajst-32496	106	32	the	the	DET
ajst-32496	106	33	traditional	traditional	ADJ
ajst-32496	106	34	synthetic	synthetic	ADJ
ajst-32496	106	35	production	production	NOUN
ajst-32496	106	36	process	process	NOUN
ajst-32496	106	37	is	be	AUX
ajst-32496	106	38	unsustainable	unsustainable	ADJ
ajst-32496	106	39	in	in	ADP
ajst-32496	106	40	terms	term	NOUN
ajst-32496	106	41	of	of	ADP
ajst-32496	106	42	resources	resource	NOUN
ajst-32496	106	43	,	,	PUNCT
ajst-32496	106	44	environment	environment	NOUN
ajst-32496	106	45	,	,	PUNCT
ajst-32496	106	46	and	and	CCONJ
ajst-32496	106	47	safety	safety	NOUN
ajst-32496	106	48	.	.	PUNCT
ajst-32496	107	1	the	the	DET
ajst-32496	107	2	green	green	ADJ
ajst-32496	107	3	blood	blood	NOUN
ajst-32496	107	4	transfusion	transfusion	NOUN
ajst-32496	107	5	is	be	AUX
ajst-32496	107	6	a	a	DET
ajst-32496	107	7	set	set	NOUN
ajst-32496	107	8	of	of	ADP
ajst-32496	107	9	theoretical	theoretical	ADJ
ajst-32496	107	10	and	and	CCONJ
ajst-32496	107	11	practical	practical	ADJ
ajst-32496	107	12	methods	method	NOUN
ajst-32496	107	13	that	that	PRON
ajst-32496	107	14	emerged	emerge	VERB
ajst-32496	107	15	to	to	PART
ajst-32496	107	16	address	address	VERB
ajst-32496	107	17	these	these	DET
ajst-32496	107	18	issues	issue	NOUN
ajst-32496	107	19	.	.	PUNCT
ajst-32496	108	1	according	accord	VERB
ajst-32496	108	2	to	to	ADP
ajst-32496	108	3	the	the	DET
ajst-32496	108	4	twelve	twelve	NUM
ajst-32496	108	5	principles	principle	NOUN
ajst-32496	108	6	of	of	ADP
ajst-32496	108	7	green	green	ADJ
ajst-32496	108	8	chemistry	chemistry	NOUN
ajst-32496	108	9	,	,	PUNCT
ajst-32496	108	10	the	the	DET
ajst-32496	108	11	core	core	ADJ
ajst-32496	108	12	idea	idea	NOUN
ajst-32496	108	13	of	of	ADP
ajst-32496	108	14	green	green	ADJ
ajst-32496	108	15	chemistry	chemistry	NOUN
ajst-32496	108	16	is	be	AUX
ajst-32496	108	17	to	to	PART
ajst-32496	108	18	eliminate	eliminate	VERB
ajst-32496	108	19	pollution	pollution	NOUN
ajst-32496	108	20	at	at	ADP
ajst-32496	108	21	its	its	PRON
ajst-32496	108	22	source	source	NOUN
ajst-32496	108	23	rather	rather	ADV
ajst-32496	108	24	than	than	ADP
ajst-32496	108	25	dealing	deal	VERB
ajst-32496	108	26	with	with	ADP
ajst-32496	108	27	it	it	PRON
ajst-32496	108	28	at	at	ADP
ajst-32496	108	29	the	the	DET
ajst-32496	108	30	end	end	NOUN
ajst-32496	108	31	of	of	ADP
ajst-32496	108	32	the	the	DET
ajst-32496	108	33	reaction	reaction	NOUN
ajst-32496	108	34	process	process	NOUN
ajst-32496	108	35	,	,	PUNCT
ajst-32496	108	36	as	as	SCONJ
ajst-32496	108	37	is	be	AUX
ajst-32496	108	38	done	do	VERB
ajst-32496	108	39	in	in	ADP
ajst-32496	108	40	traditional	traditional	ADJ
ajst-32496	108	41	methods.[8	methods.[8	NOUN
ajst-32496	108	42	]	]	PUNCT
ajst-32496	108	43	there	there	PRON
ajst-32496	108	44	are	be	VERB
ajst-32496	108	45	mainly	mainly	ADV
ajst-32496	108	46	three	three	NUM
ajst-32496	108	47	strategies	strategy	NOUN
ajst-32496	108	48	for	for	ADP
ajst-32496	108	49	improving	improve	VERB
ajst-32496	108	50	the	the	DET
ajst-32496	108	51	synthesis	synthesis	NOUN
ajst-32496	108	52	of	of	ADP
ajst-32496	108	53	sulfanilamide	sulfanilamide	NOUN
ajst-32496	108	54	using	use	VERB
ajst-32496	108	55	green	green	ADJ
ajst-32496	108	56	chemistry	chemistry	NOUN
ajst-32496	108	57	methods	method	NOUN
ajst-32496	108	58	:	:	PUNCT
ajst-32496	108	59	1	1	X
ajst-32496	108	60	.	.	X
ajst-32496	108	61	selecting	select	VERB
ajst-32496	108	62	less	less	ADV
ajst-32496	108	63	harmful	harmful	ADJ
ajst-32496	108	64	reaction	reaction	NOUN
ajst-32496	108	65	media	medium	NOUN
ajst-32496	108	66	,	,	PUNCT
ajst-32496	108	67	such	such	ADJ
ajst-32496	108	68	as	as	ADP
ajst-32496	108	69	preferentially	preferentially	ADV
ajst-32496	108	70	using	use	VERB
ajst-32496	108	71	water	water	NOUN
ajst-32496	108	72	as	as	ADP
ajst-32496	108	73	the	the	DET
ajst-32496	108	74	reaction	reaction	NOUN
ajst-32496	108	75	solvent	solvent	NOUN
ajst-32496	108	76	.	.	PUNCT
ajst-32496	109	1	2	2	X
ajst-32496	109	2	.	.	X
ajst-32496	109	3	adopt	adopt	VERB
ajst-32496	109	4	more	more	ADV
ajst-32496	109	5	efficient	efficient	ADJ
ajst-32496	109	6	synthesis	synthesis	NOUN
ajst-32496	109	7	strategies	strategy	NOUN
ajst-32496	109	8	,	,	PUNCT
ajst-32496	109	9	such	such	ADJ
ajst-32496	109	10	as	as	ADP
ajst-32496	109	11	one	one	NUM
ajst-32496	109	12	-	-	PUNCT
ajst-32496	109	13	pot	pot	NOUN
ajst-32496	109	14	synthesis	synthesis	NOUN
ajst-32496	109	15	methods	method	NOUN
ajst-32496	109	16	and	and	CCONJ
ajst-32496	109	17	multi	multi	ADJ
ajst-32496	109	18	-	-	ADJ
ajst-32496	109	19	component	component	ADJ
ajst-32496	109	20	reactions	reaction	NOUN
ajst-32496	109	21	,	,	PUNCT
ajst-32496	109	22	to	to	PART
ajst-32496	109	23	reduce	reduce	VERB
ajst-32496	109	24	waste	waste	NOUN
ajst-32496	109	25	production	production	NOUN
ajst-32496	109	26	and	and	CCONJ
ajst-32496	109	27	improve	improve	VERB
ajst-32496	109	28	atomic	atomic	ADJ
ajst-32496	109	29	economy	economy	NOUN
ajst-32496	109	30	.	.	PUNCT
ajst-32496	110	1	3	3	X
ajst-32496	110	2	.	.	X
ajst-32496	110	3	extensively	extensively	ADV
ajst-32496	110	4	employ	employ	VERB
ajst-32496	110	5	catalytic	catalytic	ADJ
ajst-32496	110	6	methods	method	NOUN
ajst-32496	110	7	to	to	PART
ajst-32496	110	8	enhance	enhance	VERB
ajst-32496	110	9	reaction	reaction	NOUN
ajst-32496	110	10	efficiency	efficiency	NOUN
ajst-32496	110	11	and	and	CCONJ
ajst-32496	110	12	reduce	reduce	VERB
ajst-32496	110	13	waste.[9	waste.[9	NOUN
ajst-32496	110	14	]	]	PUNCT
ajst-32496	110	15	142	142	NUM
ajst-32496	110	16	3.2.2	3.2.2	NUM
ajst-32496	110	17	production	production	NOUN
ajst-32496	110	18	application	application	NOUN
ajst-32496	110	19	the	the	DET
ajst-32496	110	20	‘	'	PUNCT
ajst-32496	110	21	2019	2019	NUM
ajst-32496	110	22	greener	green	ADJ
ajst-32496	110	23	synthetic	synthetic	ADJ
ajst-32496	110	24	pathways	pathway	NOUN
ajst-32496	110	25	award	award	NOUN
ajst-32496	110	26	’	'	PUNCT
ajst-32496	110	27	mentioned	mention	VERB
ajst-32496	110	28	that	that	SCONJ
ajst-32496	110	29	merck	merck	PROPN
ajst-32496	110	30	company	company	NOUN
ajst-32496	110	31	had	have	AUX
ajst-32496	110	32	made	make	VERB
ajst-32496	110	33	green	green	ADJ
ajst-32496	110	34	chemical	chemical	NOUN
ajst-32496	110	35	improvements	improvement	NOUN
ajst-32496	110	36	to	to	ADP
ajst-32496	110	37	the	the	DET
ajst-32496	110	38	production	production	NOUN
ajst-32496	110	39	process	process	NOUN
ajst-32496	110	40	of	of	ADP
ajst-32496	110	41	its	its	PRON
ajst-32496	110	42	antibiotic	antibiotic	ADJ
ajst-32496	110	43	zerbaxa	zerbaxa	NOUN
ajst-32496	110	44	.	.	PUNCT
ajst-32496	111	1	the	the	DET
ajst-32496	111	2	company	company	NOUN
ajst-32496	111	3	redesigned	redesign	VERB
ajst-32496	111	4	the	the	DET
ajst-32496	111	5	synthetic	synthetic	ADJ
ajst-32496	111	6	route	route	NOUN
ajst-32496	111	7	,	,	PUNCT
ajst-32496	111	8	reducing	reduce	VERB
ajst-32496	111	9	the	the	DET
ajst-32496	111	10	number	number	NOUN
ajst-32496	111	11	of	of	ADP
ajst-32496	111	12	reaction	reaction	NOUN
ajst-32496	111	13	steps	step	NOUN
ajst-32496	111	14	.	.	PUNCT
ajst-32496	112	1	for	for	ADP
ajst-32496	112	2	instance	instance	NOUN
ajst-32496	112	3	,	,	PUNCT
ajst-32496	112	4	through	through	ADP
ajst-32496	112	5	more	more	ADV
ajst-32496	112	6	efficient	efficient	ADJ
ajst-32496	112	7	chemical	chemical	NOUN
ajst-32496	112	8	reactions	reaction	NOUN
ajst-32496	112	9	,	,	PUNCT
ajst-32496	112	10	multiple	multiple	ADJ
ajst-32496	112	11	steps	step	NOUN
ajst-32496	112	12	were	be	AUX
ajst-32496	112	13	integrated	integrate	VERB
ajst-32496	112	14	or	or	CCONJ
ajst-32496	112	15	replaced	replace	VERB
ajst-32496	112	16	with	with	ADP
ajst-32496	112	17	simpler	simple	ADJ
ajst-32496	112	18	reactions	reaction	NOUN
ajst-32496	112	19	,	,	PUNCT
ajst-32496	112	20	thereby	thereby	ADV
ajst-32496	112	21	avoiding	avoid	VERB
ajst-32496	112	22	the	the	DET
ajst-32496	112	23	formation	formation	NOUN
ajst-32496	112	24	of	of	ADP
ajst-32496	112	25	unnecessary	unnecessary	ADJ
ajst-32496	112	26	intermediate	intermediate	ADJ
ajst-32496	112	27	products	product	NOUN
ajst-32496	112	28	.	.	PUNCT
ajst-32496	113	1	by	by	ADP
ajst-32496	113	2	adopting	adopt	VERB
ajst-32496	113	3	advanced	advanced	ADJ
ajst-32496	113	4	crystallization	crystallization	NOUN
ajst-32496	113	5	purification	purification	NOUN
ajst-32496	113	6	technology	technology	NOUN
ajst-32496	113	7	,	,	PUNCT
ajst-32496	113	8	they	they	PRON
ajst-32496	113	9	have	have	AUX
ajst-32496	113	10	replaced	replace	VERB
ajst-32496	113	11	traditional	traditional	ADJ
ajst-32496	113	12	column	column	NOUN
ajst-32496	113	13	chromatography	chromatography	NOUN
ajst-32496	113	14	and	and	CCONJ
ajst-32496	113	15	other	other	ADJ
ajst-32496	113	16	separation	separation	NOUN
ajst-32496	113	17	methods	method	NOUN
ajst-32496	113	18	.	.	PUNCT
ajst-32496	114	1	the	the	DET
ajst-32496	114	2	crystallization	crystallization	NOUN
ajst-32496	114	3	process	process	NOUN
ajst-32496	114	4	can	can	AUX
ajst-32496	114	5	more	more	ADV
ajst-32496	114	6	efficiently	efficiently	ADV
ajst-32496	114	7	separate	separate	ADJ
ajst-32496	114	8	and	and	CCONJ
ajst-32496	114	9	purify	purify	VERB
ajst-32496	114	10	products	product	NOUN
ajst-32496	114	11	,	,	PUNCT
ajst-32496	114	12	thereby	thereby	ADV
ajst-32496	114	13	reducing	reduce	VERB
ajst-32496	114	14	reliance	reliance	NOUN
ajst-32496	114	15	on	on	ADP
ajst-32496	114	16	organic	organic	ADJ
ajst-32496	114	17	solvents	solvent	NOUN
ajst-32496	114	18	.	.	PUNCT
ajst-32496	115	1	moreover	moreover	ADV
ajst-32496	115	2	,	,	PUNCT
ajst-32496	115	3	environmentally	environmentally	ADV
ajst-32496	115	4	friendly	friendly	ADJ
ajst-32496	115	5	catalysts	catalyst	NOUN
ajst-32496	115	6	and	and	CCONJ
ajst-32496	115	7	reagents	reagent	NOUN
ajst-32496	115	8	were	be	AUX
ajst-32496	115	9	selected	select	VERB
ajst-32496	115	10	to	to	PART
ajst-32496	115	11	reduce	reduce	VERB
ajst-32496	115	12	the	the	DET
ajst-32496	115	13	use	use	NOUN
ajst-32496	115	14	of	of	ADP
ajst-32496	115	15	toxic	toxic	ADJ
ajst-32496	115	16	and	and	CCONJ
ajst-32496	115	17	harmful	harmful	ADJ
ajst-32496	115	18	chemicals	chemical	NOUN
ajst-32496	115	19	.	.	PUNCT
ajst-32496	116	1	for	for	ADP
ajst-32496	116	2	instance	instance	NOUN
ajst-32496	116	3	,	,	PUNCT
ajst-32496	116	4	using	use	VERB
ajst-32496	116	5	biocatalysts	biocatalyst	NOUN
ajst-32496	116	6	or	or	CCONJ
ajst-32496	116	7	low	low	ADJ
ajst-32496	116	8	-	-	PUNCT
ajst-32496	116	9	toxic	toxic	ADJ
ajst-32496	116	10	chemical	chemical	NOUN
ajst-32496	116	11	reagents	reagent	NOUN
ajst-32496	116	12	can	can	AUX
ajst-32496	116	13	minimize	minimize	VERB
ajst-32496	116	14	the	the	DET
ajst-32496	116	15	environmental	environmental	ADJ
ajst-32496	116	16	impact	impact	NOUN
ajst-32496	116	17	and	and	CCONJ
ajst-32496	116	18	operator	operator	NOUN
ajst-32496	116	19	exposure	exposure	NOUN
ajst-32496	116	20	during	during	ADP
ajst-32496	116	21	the	the	DET
ajst-32496	116	22	production	production	NOUN
ajst-32496	116	23	process	process	NOUN
ajst-32496	116	24	.	.	PUNCT
ajst-32496	117	1	the	the	DET
ajst-32496	117	2	synthesis	synthesis	NOUN
ajst-32496	117	3	route	route	NOUN
ajst-32496	117	4	was	be	AUX
ajst-32496	117	5	redesigned	redesign	VERB
ajst-32496	117	6	to	to	PART
ajst-32496	117	7	reduce	reduce	VERB
ajst-32496	117	8	the	the	DET
ajst-32496	117	9	number	number	NOUN
ajst-32496	117	10	of	of	ADP
ajst-32496	117	11	reaction	reaction	NOUN
ajst-32496	117	12	steps	step	NOUN
ajst-32496	117	13	.	.	PUNCT
ajst-32496	118	1	for	for	ADP
ajst-32496	118	2	example	example	NOUN
ajst-32496	118	3	,	,	PUNCT
ajst-32496	118	4	through	through	ADP
ajst-32496	118	5	more	more	ADV
ajst-32496	118	6	efficient	efficient	ADJ
ajst-32496	118	7	chemical	chemical	NOUN
ajst-32496	118	8	reactions	reaction	NOUN
ajst-32496	118	9	,	,	PUNCT
ajst-32496	118	10	multiple	multiple	ADJ
ajst-32496	118	11	steps	step	NOUN
ajst-32496	118	12	were	be	AUX
ajst-32496	118	13	integrated	integrate	VERB
ajst-32496	118	14	or	or	CCONJ
ajst-32496	118	15	replaced	replace	VERB
ajst-32496	118	16	with	with	ADP
ajst-32496	118	17	simpler	simple	ADJ
ajst-32496	118	18	reactions	reaction	NOUN
ajst-32496	118	19	,	,	PUNCT
ajst-32496	118	20	avoiding	avoid	VERB
ajst-32496	118	21	the	the	DET
ajst-32496	118	22	generation	generation	NOUN
ajst-32496	118	23	of	of	ADP
ajst-32496	118	24	unnecessary	unnecessary	ADJ
ajst-32496	118	25	intermediate	intermediate	ADJ
ajst-32496	118	26	products	product	NOUN
ajst-32496	118	27	.	.	PUNCT
ajst-32496	119	1	after	after	ADP
ajst-32496	119	2	the	the	DET
ajst-32496	119	3	optimization	optimization	NOUN
ajst-32496	119	4	,	,	PUNCT
ajst-32496	119	5	the	the	DET
ajst-32496	119	6	cost	cost	NOUN
ajst-32496	119	7	of	of	ADP
ajst-32496	119	8	raw	raw	ADJ
ajst-32496	119	9	materials	material	NOUN
ajst-32496	119	10	has	have	AUX
ajst-32496	119	11	decreased	decrease	VERB
ajst-32496	119	12	by	by	ADP
ajst-32496	119	13	approximately	approximately	ADV
ajst-32496	119	14	30	30	NUM
ajst-32496	119	15	%	%	NOUN
ajst-32496	119	16	40	40	NUM
ajst-32496	119	17	%	%	NOUN
ajst-32496	119	18	.	.	PUNCT
ajst-32496	120	1	the	the	DET
ajst-32496	120	2	output	output	NOUN
ajst-32496	120	3	has	have	AUX
ajst-32496	120	4	increased	increase	VERB
ajst-32496	120	5	by	by	ADP
ajst-32496	120	6	approximately	approximately	ADV
ajst-32496	120	7	20	20	NUM
ajst-32496	120	8	%	%	NOUN
ajst-32496	120	9	to	to	PART
ajst-32496	120	10	30	30	NUM
ajst-32496	120	11	%	%	NOUN
ajst-32496	120	12	with	with	ADP
ajst-32496	120	13	the	the	DET
ajst-32496	120	14	more	more	ADV
ajst-32496	120	15	efficient	efficient	ADJ
ajst-32496	120	16	synthesis	synthesis	NOUN
ajst-32496	120	17	and	and	CCONJ
ajst-32496	120	18	purification	purification	NOUN
ajst-32496	120	19	processes	process	NOUN
ajst-32496	120	20	.	.	PUNCT
ajst-32496	121	1	the	the	DET
ajst-32496	121	2	water	water	NOUN
ajst-32496	121	3	-	-	PUNCT
ajst-32496	121	4	saving	save	VERB
ajst-32496	121	5	effect	effect	NOUN
ajst-32496	121	6	is	be	AUX
ajst-32496	121	7	also	also	ADV
ajst-32496	121	8	remarkable	remarkable	ADJ
ajst-32496	121	9	.	.	PUNCT
ajst-32496	122	1	the	the	DET
ajst-32496	122	2	consumption	consumption	NOUN
ajst-32496	122	3	of	of	ADP
ajst-32496	122	4	water	water	NOUN
ajst-32496	122	5	resources	resource	NOUN
ajst-32496	122	6	during	during	ADP
ajst-32496	122	7	the	the	DET
ajst-32496	122	8	production	production	NOUN
ajst-32496	122	9	process	process	NOUN
ajst-32496	122	10	has	have	AUX
ajst-32496	122	11	been	be	AUX
ajst-32496	122	12	reduced	reduce	VERB
ajst-32496	122	13	by	by	ADP
ajst-32496	122	14	approximately	approximately	ADV
ajst-32496	122	15	50	50	NUM
ajst-32496	122	16	%	%	NOUN
ajst-32496	122	17	.	.	PUNCT
ajst-32496	123	1	the	the	DET
ajst-32496	123	2	carbon	carbon	NOUN
ajst-32496	123	3	footprint	footprint	NOUN
ajst-32496	123	4	has	have	AUX
ajst-32496	123	5	been	be	AUX
ajst-32496	123	6	reduced	reduce	VERB
ajst-32496	123	7	by	by	ADP
ajst-32496	123	8	approximately	approximately	ADV
ajst-32496	123	9	40	40	NUM
ajst-32496	123	10	-50	-50	NUM
ajst-32496	123	11	%	%	NOUN
ajst-32496	123	12	.	.	PUNCT
ajst-32496	124	1	energy	energy	NOUN
ajst-32496	124	2	consumption	consumption	NOUN
ajst-32496	124	3	has	have	AUX
ajst-32496	124	4	decreased	decrease	VERB
ajst-32496	124	5	by	by	ADP
ajst-32496	124	6	approximately	approximately	ADV
ajst-32496	124	7	30	30	NUM
ajst-32496	124	8	%	%	NOUN
ajst-32496	124	9	to	to	PART
ajst-32496	124	10	40	40	NUM
ajst-32496	124	11	%	%	NOUN
ajst-32496	124	12	.	.	PUNCT
ajst-32496	125	1	from	from	ADP
ajst-32496	125	2	this	this	PRON
ajst-32496	125	3	,	,	PUNCT
ajst-32496	125	4	it	it	PRON
ajst-32496	125	5	is	be	AUX
ajst-32496	125	6	evident	evident	ADJ
ajst-32496	125	7	that	that	SCONJ
ajst-32496	125	8	the	the	DET
ajst-32496	125	9	application	application	NOUN
ajst-32496	125	10	of	of	ADP
ajst-32496	125	11	green	green	ADJ
ajst-32496	125	12	chemical	chemical	PROPN
ajst-32496	125	13	technology	technology	NOUN
ajst-32496	125	14	to	to	PART
ajst-32496	125	15	optimize	optimize	VERB
ajst-32496	125	16	the	the	DET
ajst-32496	125	17	production	production	NOUN
ajst-32496	125	18	process	process	NOUN
ajst-32496	125	19	of	of	ADP
ajst-32496	125	20	antibiotics	antibiotic	NOUN
ajst-32496	125	21	has	have	AUX
ajst-32496	125	22	yielded	yield	VERB
ajst-32496	125	23	significant	significant	ADJ
ajst-32496	125	24	results	result	NOUN
ajst-32496	125	25	in	in	ADP
ajst-32496	125	26	multiple	multiple	ADJ
ajst-32496	125	27	aspects	aspect	NOUN
ajst-32496	125	28	,	,	PUNCT
ajst-32496	125	29	including	include	VERB
ajst-32496	125	30	resource	resource	NOUN
ajst-32496	125	31	utilization	utilization	NOUN
ajst-32496	125	32	,	,	PUNCT
ajst-32496	125	33	cost	cost	NOUN
ajst-32496	125	34	control	control	NOUN
ajst-32496	125	35	,	,	PUNCT
ajst-32496	125	36	and	and	CCONJ
ajst-32496	125	37	environmental	environmental	ADJ
ajst-32496	125	38	protection	protection	NOUN
ajst-32496	125	39	.	.	PUNCT
ajst-32496	126	1	this	this	PRON
ajst-32496	126	2	demonstrates	demonstrate	VERB
ajst-32496	126	3	that	that	SCONJ
ajst-32496	126	4	green	green	ADJ
ajst-32496	126	5	chemistry	chemistry	NOUN
ajst-32496	126	6	has	have	VERB
ajst-32496	126	7	significant	significant	ADJ
ajst-32496	126	8	application	application	NOUN
ajst-32496	126	9	value	value	NOUN
ajst-32496	126	10	and	and	CCONJ
ajst-32496	126	11	development	development	NOUN
ajst-32496	126	12	potential	potential	NOUN
ajst-32496	126	13	in	in	ADP
ajst-32496	126	14	the	the	DET
ajst-32496	126	15	production	production	NOUN
ajst-32496	126	16	of	of	ADP
ajst-32496	126	17	antibiotics	antibiotic	NOUN
ajst-32496	126	18	,	,	PUNCT
ajst-32496	126	19	enabling	enable	VERB
ajst-32496	126	20	a	a	DET
ajst-32496	126	21	win	win	NOUN
ajst-32496	126	22	-	-	PUNCT
ajst-32496	126	23	win	win	NOUN
ajst-32496	126	24	situation	situation	NOUN
ajst-32496	126	25	that	that	PRON
ajst-32496	126	26	balances	balance	VERB
ajst-32496	126	27	economic	economic	ADJ
ajst-32496	126	28	benefits	benefit	NOUN
ajst-32496	126	29	with	with	ADP
ajst-32496	126	30	environmental	environmental	ADJ
ajst-32496	126	31	benefits	benefit	NOUN
ajst-32496	126	32	.	.	PUNCT
ajst-32496	127	1	3.3	3.3	NUM
ajst-32496	127	2	electrochemical	electrochemical	ADJ
ajst-32496	127	3	synthesis	synthesis	NOUN
ajst-32496	127	4	3.3.1	3.3.1	NUM
ajst-32496	127	5	optimising	optimise	VERB
ajst-32496	127	6	with	with	ADP
ajst-32496	127	7	electrochemical	electrochemical	ADJ
ajst-32496	127	8	synthesis	synthesis	NOUN
ajst-32496	127	9	the	the	DET
ajst-32496	127	10	electrochemical	electrochemical	ADJ
ajst-32496	127	11	method	method	NOUN
ajst-32496	127	12	achieves	achieve	VERB
ajst-32496	127	13	the	the	DET
ajst-32496	127	14	conversion	conversion	NOUN
ajst-32496	127	15	between	between	ADP
ajst-32496	127	16	electrical	electrical	ADJ
ajst-32496	127	17	energy	energy	NOUN
ajst-32496	127	18	and	and	CCONJ
ajst-32496	127	19	chemical	chemical	NOUN
ajst-32496	127	20	energy	energy	NOUN
ajst-32496	127	21	through	through	ADP
ajst-32496	127	22	electron	electron	NOUN
ajst-32496	127	23	transfer	transfer	NOUN
ajst-32496	127	24	.	.	PUNCT
ajst-32496	128	1	in	in	ADP
ajst-32496	128	2	organic	organic	ADJ
ajst-32496	128	3	synthesis	synthesis	NOUN
ajst-32496	128	4	,	,	PUNCT
ajst-32496	128	5	organic	organic	ADJ
ajst-32496	128	6	electrocatalysis	electrocatalysis	NOUN
ajst-32496	128	7	utilizes	utilize	VERB
ajst-32496	128	8	electrons	electron	NOUN
ajst-32496	128	9	as	as	ADP
ajst-32496	128	10	clean	clean	ADJ
ajst-32496	128	11	and	and	CCONJ
ajst-32496	128	12	controllable	controllable	ADJ
ajst-32496	128	13	reagents	reagent	NOUN
ajst-32496	128	14	to	to	PART
ajst-32496	128	15	drive	drive	VERB
ajst-32496	128	16	reactions	reaction	NOUN
ajst-32496	128	17	,	,	PUNCT
ajst-32496	128	18	providing	provide	VERB
ajst-32496	128	19	a	a	DET
ajst-32496	128	20	more	more	ADV
ajst-32496	128	21	environmentally	environmentally	ADV
ajst-32496	128	22	friendly	friendly	ADJ
ajst-32496	128	23	and	and	CCONJ
ajst-32496	128	24	efficient	efficient	ADJ
ajst-32496	128	25	approach	approach	NOUN
ajst-32496	128	26	to	to	ADP
ajst-32496	128	27	synthesis	synthesis	NOUN
ajst-32496	128	28	.	.	PUNCT
ajst-32496	129	1	in	in	ADP
ajst-32496	129	2	‘	'	PUNCT
ajst-32496	129	3	electrochemical	electrochemical	ADJ
ajst-32496	129	4	synthesis	synthesis	NOUN
ajst-32496	129	5	of	of	ADP
ajst-32496	129	6	sulfonamide	sulfonamide	NOUN
ajst-32496	129	7	in	in	ADP
ajst-32496	129	8	single	single	ADJ
ajst-32496	129	9	-	-	PUNCT
ajst-32496	129	10	pass	pass	NOUN
ajst-32496	129	11	flow	flow	NOUN
ajst-32496	129	12	’	'	PUNCT
ajst-32496	129	13	,	,	PUNCT
ajst-32496	129	14	johannes	johannes	PROPN
ajst-32496	129	15	schneider	schneider	PROPN
ajst-32496	129	16	,	,	PUNCT
ajst-32496	129	17	stephan	stephan	PROPN
ajst-32496	129	18	p.	p.	PROPN
ajst-32496	129	19	blum	blum	PROPN
ajst-32496	129	20	,	,	PUNCT
ajst-32496	129	21	and	and	CCONJ
ajst-32496	129	22	siegfried	siegfried	PROPN
ajst-32496	129	23	r.	r.	PROPN
ajst-32496	130	1	waldvogel	waldvogel	AUX
ajst-32496	130	2	gave	give	VERB
ajst-32496	130	3	a	a	DET
ajst-32496	130	4	detailed	detailed	ADJ
ajst-32496	130	5	introduction	introduction	NOUN
ajst-32496	130	6	to	to	ADP
ajst-32496	130	7	a	a	DET
ajst-32496	130	8	new	new	ADJ
ajst-32496	130	9	method	method	NOUN
ajst-32496	130	10	for	for	ADP
ajst-32496	130	11	electrochemical	electrochemical	ADJ
ajst-32496	130	12	flow	flow	NOUN
ajst-32496	130	13	synthesis	synthesis	NOUN
ajst-32496	130	14	of	of	ADP
ajst-32496	130	15	malonamide	malonamide	NOUN
ajst-32496	130	16	.	.	PUNCT
ajst-32496	131	1	firstly	firstly	ADV
ajst-32496	131	2	,	,	PUNCT
ajst-32496	131	3	the	the	DET
ajst-32496	131	4	new	new	ADJ
ajst-32496	131	5	method	method	NOUN
ajst-32496	131	6	utilizes	utilize	VERB
ajst-32496	131	7	electrons	electron	NOUN
ajst-32496	131	8	and	and	CCONJ
ajst-32496	131	9	achieves	achieve	VERB
ajst-32496	131	10	an	an	DET
ajst-32496	131	11	atomic	atomic	ADJ
ajst-32496	131	12	economy	economy	NOUN
ajst-32496	131	13	of	of	ADP
ajst-32496	131	14	100	100	NUM
ajst-32496	131	15	%	%	NOUN
ajst-32496	131	16	,	,	PUNCT
ajst-32496	131	17	thereby	thereby	ADV
ajst-32496	131	18	eliminating	eliminate	VERB
ajst-32496	131	19	the	the	DET
ajst-32496	131	20	generation	generation	NOUN
ajst-32496	131	21	of	of	ADP
ajst-32496	131	22	harmful	harmful	ADJ
ajst-32496	131	23	waste	waste	NOUN
ajst-32496	131	24	at	at	ADP
ajst-32496	131	25	the	the	DET
ajst-32496	131	26	source	source	NOUN
ajst-32496	131	27	.	.	PUNCT
ajst-32496	132	1	second	second	ADJ
ajst-32496	132	2	,	,	PUNCT
ajst-32496	132	3	the	the	DET
ajst-32496	132	4	new	new	ADJ
ajst-32496	132	5	method	method	NOUN
ajst-32496	132	6	does	do	AUX
ajst-32496	132	7	not	not	PART
ajst-32496	132	8	require	require	VERB
ajst-32496	132	9	pre	pre	ADJ
ajst-32496	132	10	-	-	NOUN
ajst-32496	132	11	functionalisation	functionalisation	NOUN
ajst-32496	132	12	.	.	PUNCT
ajst-32496	133	1	it	it	PRON
ajst-32496	133	2	directly	directly	ADV
ajst-32496	133	3	starts	start	VERB
ajst-32496	133	4	from	from	ADP
ajst-32496	133	5	unactivated	unactivated	ADJ
ajst-32496	133	6	raw	raw	ADJ
ajst-32496	133	7	materials	material	NOUN
ajst-32496	133	8	(	(	PUNCT
ajst-32496	133	9	aromatic	aromatic	ADJ
ajst-32496	133	10	compounds	compound	NOUN
ajst-32496	133	11	,	,	PUNCT
ajst-32496	133	12	amines	amine	NOUN
ajst-32496	133	13	,	,	PUNCT
ajst-32496	133	14	so2	so2	PROPN
ajst-32496	133	15	)	)	PUNCT
ajst-32496	133	16	and	and	CCONJ
ajst-32496	133	17	synthesises	synthesis	NOUN
ajst-32496	133	18	in	in	ADP
ajst-32496	133	19	one	one	NUM
ajst-32496	133	20	step	step	NOUN
ajst-32496	133	21	.	.	PUNCT
ajst-32496	134	1	the	the	DET
ajst-32496	134	2	raw	raw	ADJ
ajst-32496	134	3	materials	material	NOUN
ajst-32496	134	4	are	be	AUX
ajst-32496	134	5	readily	readily	ADV
ajst-32496	134	6	available	available	ADJ
ajst-32496	134	7	and	and	CCONJ
ajst-32496	134	8	inexpensive	inexpensive	ADJ
ajst-32496	134	9	,	,	PUNCT
ajst-32496	134	10	which	which	PRON
ajst-32496	134	11	not	not	PART
ajst-32496	134	12	only	only	ADV
ajst-32496	134	13	reduces	reduce	VERB
ajst-32496	134	14	production	production	NOUN
ajst-32496	134	15	costs	cost	NOUN
ajst-32496	134	16	but	but	CCONJ
ajst-32496	134	17	also	also	ADV
ajst-32496	134	18	avoids	avoid	VERB
ajst-32496	134	19	the	the	DET
ajst-32496	134	20	hazardous	hazardous	ADJ
ajst-32496	134	21	situation	situation	NOUN
ajst-32496	134	22	caused	cause	VERB
ajst-32496	134	23	by	by	ADP
ajst-32496	134	24	the	the	DET
ajst-32496	134	25	instability	instability	NOUN
ajst-32496	134	26	of	of	ADP
ajst-32496	134	27	toxic	toxic	ADJ
ajst-32496	134	28	substances	substance	NOUN
ajst-32496	134	29	.	.	PUNCT
ajst-32496	135	1	third	third	ADJ
ajst-32496	135	2	,	,	PUNCT
ajst-32496	135	3	electrochemical	electrochemical	ADJ
ajst-32496	135	4	synthesis	synthesis	NOUN
ajst-32496	135	5	controls	control	VERB
ajst-32496	135	6	the	the	DET
ajst-32496	135	7	reaction	reaction	NOUN
ajst-32496	135	8	by	by	ADP
ajst-32496	135	9	precisely	precisely	ADV
ajst-32496	135	10	regulating	regulate	VERB
ajst-32496	135	11	the	the	DET
ajst-32496	135	12	current	current	ADJ
ajst-32496	135	13	density	density	NOUN
ajst-32496	135	14	and	and	CCONJ
ajst-32496	135	15	charge	charge	NOUN
ajst-32496	135	16	quantity	quantity	NOUN
ajst-32496	135	17	.	.	PUNCT
ajst-32496	136	1	lastly	lastly	ADV
ajst-32496	136	2	,	,	PUNCT
ajst-32496	136	3	the	the	DET
ajst-32496	136	4	new	new	ADJ
ajst-32496	136	5	method	method	NOUN
ajst-32496	136	6	does	do	AUX
ajst-32496	136	7	not	not	PART
ajst-32496	136	8	use	use	VERB
ajst-32496	136	9	toxic	toxic	ADJ
ajst-32496	136	10	substances	substance	NOUN
ajst-32496	136	11	such	such	ADJ
ajst-32496	136	12	as	as	ADP
ajst-32496	136	13	chlorosulfonic	chlorosulfonic	ADJ
ajst-32496	136	14	acid	acid	NOUN
ajst-32496	136	15	,	,	PUNCT
ajst-32496	136	16	thereby	thereby	ADV
ajst-32496	136	17	enhancing	enhance	VERB
ajst-32496	136	18	safety	safety	NOUN
ajst-32496	136	19	.	.	PUNCT
ajst-32496	137	1	the	the	DET
ajst-32496	137	2	downstream	downstream	ADJ
ajst-32496	137	3	processing	processing	NOUN
ajst-32496	137	4	is	be	AUX
ajst-32496	137	5	also	also	ADV
ajst-32496	137	6	simpler	simple	ADJ
ajst-32496	137	7	,	,	PUNCT
ajst-32496	137	8	making	make	VERB
ajst-32496	137	9	it	it	PRON
ajst-32496	137	10	suitable	suitable	ADJ
ajst-32496	137	11	for	for	ADP
ajst-32496	137	12	large	large	ADJ
ajst-32496	137	13	-	-	PUNCT
ajst-32496	137	14	scale	scale	NOUN
ajst-32496	137	15	production	production	NOUN
ajst-32496	137	16	.	.	PUNCT
ajst-32496	138	1	3.3.2	3.3.2	NUM
ajst-32496	138	2	production	production	NOUN
ajst-32496	138	3	application	application	NOUN
ajst-32496	138	4	the	the	DET
ajst-32496	138	5	‘	'	PUNCT
ajst-32496	138	6	global	global	ADJ
ajst-32496	138	7	sulfonamide	sulfonamide	NOUN
ajst-32496	138	8	industry	industry	NOUN
ajst-32496	138	9	technology	technology	NOUN
ajst-32496	138	10	trends	trend	NOUN
ajst-32496	138	11	and	and	CCONJ
ajst-32496	138	12	investment	investment	NOUN
ajst-32496	138	13	analysis	analysis	NOUN
ajst-32496	138	14	in	in	ADP
ajst-32496	138	15	2025	2025	NUM
ajst-32496	138	16	’	'	PUNCT
ajst-32496	138	17	report	report	NOUN
ajst-32496	138	18	indicates	indicate	VERB
ajst-32496	138	19	that	that	SCONJ
ajst-32496	138	20	electrochemical	electrochemical	ADJ
ajst-32496	138	21	synthesis	synthesis	NOUN
ajst-32496	138	22	technology	technology	NOUN
ajst-32496	138	23	has	have	AUX
ajst-32496	138	24	entered	enter	VERB
ajst-32496	138	25	the	the	DET
ajst-32496	138	26	stage	stage	NOUN
ajst-32496	138	27	of	of	ADP
ajst-32496	138	28	large	large	ADJ
ajst-32496	138	29	-	-	PUNCT
ajst-32496	138	30	scale	scale	NOUN
ajst-32496	138	31	validation	validation	NOUN
ajst-32496	138	32	.	.	PUNCT
ajst-32496	139	1	the	the	DET
ajst-32496	139	2	non	non	ADJ
ajst-32496	139	3	-	-	ADJ
ajst-32496	139	4	metallic	metallic	ADJ
ajst-32496	139	5	catalyst	catalyst	NOUN
ajst-32496	139	6	-	-	PUNCT
ajst-32496	139	7	free	free	ADJ
ajst-32496	139	8	electrochemical	electrochemical	ADJ
ajst-32496	139	9	multi	multi	ADJ
ajst-32496	139	10	-	-	ADJ
ajst-32496	139	11	component	component	ADJ
ajst-32496	139	12	synthesis	synthesis	NOUN
ajst-32496	139	13	process	process	NOUN
ajst-32496	139	14	has	have	AUX
ajst-32496	139	15	become	become	VERB
ajst-32496	139	16	mainstream	mainstream	ADJ
ajst-32496	139	17	.	.	PUNCT
ajst-32496	140	1	for	for	ADP
ajst-32496	140	2	instance	instance	NOUN
ajst-32496	140	3	,	,	PUNCT
ajst-32496	140	4	the	the	DET
ajst-32496	140	5	single	single	ADJ
ajst-32496	140	6	-	-	PUNCT
ajst-32496	140	7	step	step	NOUN
ajst-32496	140	8	continuous	continuous	ADJ
ajst-32496	140	9	-	-	PUNCT
ajst-32496	140	10	flow	flow	NOUN
ajst-32496	140	11	electrochemical	electrochemical	ADJ
ajst-32496	140	12	synthesis	synthesis	NOUN
ajst-32496	140	13	technology	technology	NOUN
ajst-32496	140	14	for	for	ADP
ajst-32496	140	15	sulfonyl	sulfonyl	NOUN
ajst-32496	140	16	amides	amide	NOUN
ajst-32496	140	17	developed	develop	VERB
ajst-32496	140	18	by	by	ADP
ajst-32496	140	19	the	the	DET
ajst-32496	140	20	university	university	NOUN
ajst-32496	140	21	of	of	ADP
ajst-32496	140	22	mainz	mainz	PROPN
ajst-32496	140	23	in	in	ADP
ajst-32496	140	24	germany	germany	PROPN
ajst-32496	140	25	,	,	PUNCT
ajst-32496	140	26	in	in	ADP
ajst-32496	140	27	collaboration	collaboration	NOUN
ajst-32496	140	28	with	with	ADP
ajst-32496	140	29	merck	merck	PROPN
ajst-32496	140	30	,	,	PUNCT
ajst-32496	140	31	143	143	NUM
ajst-32496	140	32	generates	generate	VERB
ajst-32496	140	33	sulfonyl	sulfonyl	NOUN
ajst-32496	140	34	chloride	chloride	NOUN
ajst-32496	140	35	intermediates	intermediate	NOUN
ajst-32496	140	36	in	in	ADP
ajst-32496	140	37	situ	situ	NOUN
ajst-32496	140	38	from	from	ADP
ajst-32496	140	39	so2	so2	PROPN
ajst-32496	140	40	,	,	PUNCT
ajst-32496	140	41	thereby	thereby	ADV
ajst-32496	140	42	avoiding	avoid	VERB
ajst-32496	140	43	the	the	DET
ajst-32496	140	44	use	use	NOUN
ajst-32496	140	45	of	of	ADP
ajst-32496	140	46	highly	highly	ADV
ajst-32496	140	47	toxic	toxic	ADJ
ajst-32496	140	48	thiosulfuric	thiosulfuric	ADJ
ajst-32496	140	49	acid	acid	NOUN
ajst-32496	140	50	in	in	ADP
ajst-32496	140	51	traditional	traditional	ADJ
ajst-32496	140	52	processes	process	NOUN
ajst-32496	140	53	.	.	PUNCT
ajst-32496	141	1	the	the	DET
ajst-32496	141	2	yield	yield	NOUN
ajst-32496	141	3	reaches	reach	VERB
ajst-32496	141	4	70	70	NUM
ajst-32496	141	5	-	-	SYM
ajst-32496	141	6	92	92	NUM
ajst-32496	141	7	%	%	NOUN
ajst-32496	141	8	at	at	ADP
ajst-32496	141	9	the	the	DET
ajst-32496	141	10	pilot	pilot	NOUN
ajst-32496	141	11	scale	scale	NOUN
ajst-32496	141	12	,	,	PUNCT
ajst-32496	141	13	with	with	ADP
ajst-32496	141	14	an	an	DET
ajst-32496	141	15	electric	electric	ADJ
ajst-32496	141	16	current	current	ADJ
ajst-32496	141	17	efficiency	efficiency	NOUN
ajst-32496	141	18	of	of	ADP
ajst-32496	141	19	over	over	ADP
ajst-32496	141	20	85	85	NUM
ajst-32496	141	21	%	%	NOUN
ajst-32496	141	22	.	.	PUNCT
ajst-32496	142	1	the	the	DET
ajst-32496	142	2	pilot	pilot	NOUN
ajst-32496	142	3	project	project	NOUN
ajst-32496	142	4	for	for	ADP
ajst-32496	142	5	the	the	DET
ajst-32496	142	6	electrochemical	electrochemical	ADJ
ajst-32496	142	7	reduction	reduction	NOUN
ajst-32496	142	8	of	of	ADP
ajst-32496	142	9	cyanosulfonyl	cyanosulfonyl	NOUN
ajst-32496	142	10	amide	amide	NOUN
ajst-32496	142	11	by	by	ADP
ajst-32496	142	12	basf	basf	PROPN
ajst-32496	142	13	,	,	PUNCT
ajst-32496	142	14	a	a	DET
ajst-32496	142	15	european	european	PROPN
ajst-32496	142	16	chemical	chemical	PROPN
ajst-32496	142	17	giant	giant	NOUN
ajst-32496	142	18	,	,	PUNCT
ajst-32496	142	19	has	have	AUX
ajst-32496	142	20	completed	complete	VERB
ajst-32496	142	21	a	a	DET
ajst-32496	142	22	500	500	NUM
ajst-32496	142	23	ml	ml	NOUN
ajst-32496	142	24	scale	scale	NOUN
ajst-32496	142	25	validation	validation	NOUN
ajst-32496	142	26	.	.	PUNCT
ajst-32496	143	1	the	the	DET
ajst-32496	143	2	yield	yield	NOUN
ajst-32496	143	3	of	of	ADP
ajst-32496	143	4	the	the	DET
ajst-32496	143	5	mafenide	mafenide	NOUN
ajst-32496	143	6	intermediate	intermediate	ADJ
ajst-32496	143	7	reached	reach	VERB
ajst-32496	143	8	80	80	NUM
ajst-32496	143	9	-	-	SYM
ajst-32496	143	10	86	86	NUM
ajst-32496	143	11	%	%	NOUN
ajst-32496	143	12	.	.	PUNCT
ajst-32496	144	1	by	by	ADP
ajst-32496	144	2	generating	generate	VERB
ajst-32496	144	3	hydrogen	hydrogen	NOUN
ajst-32496	144	4	in	in	ADP
ajst-32496	144	5	situ	situ	NOUN
ajst-32496	144	6	instead	instead	ADV
ajst-32496	144	7	of	of	ADP
ajst-32496	144	8	using	use	VERB
ajst-32496	144	9	high	high	ADJ
ajst-32496	144	10	-	-	PUNCT
ajst-32496	144	11	pressure	pressure	NOUN
ajst-32496	144	12	hydrogenation	hydrogenation	NOUN
ajst-32496	144	13	,	,	PUNCT
ajst-32496	144	14	the	the	DET
ajst-32496	144	15	equipment	equipment	NOUN
ajst-32496	144	16	investment	investment	NOUN
ajst-32496	144	17	was	be	AUX
ajst-32496	144	18	reduced	reduce	VERB
ajst-32496	144	19	by	by	ADP
ajst-32496	144	20	20	20	NUM
ajst-32496	144	21	%	%	NOUN
ajst-32496	144	22	.	.	PUNCT
ajst-32496	145	1	it	it	PRON
ajst-32496	145	2	is	be	AUX
ajst-32496	145	3	anticipated	anticipate	VERB
ajst-32496	145	4	that	that	SCONJ
ajst-32496	145	5	a	a	DET
ajst-32496	145	6	commercial	commercial	ADJ
ajst-32496	145	7	production	production	NOUN
ajst-32496	145	8	line	line	NOUN
ajst-32496	145	9	with	with	ADP
ajst-32496	145	10	an	an	DET
ajst-32496	145	11	annual	annual	ADJ
ajst-32496	145	12	output	output	NOUN
ajst-32496	145	13	of	of	ADP
ajst-32496	145	14	200	200	NUM
ajst-32496	145	15	tons	ton	NOUN
ajst-32496	145	16	will	will	AUX
ajst-32496	145	17	be	be	AUX
ajst-32496	145	18	established	establish	VERB
ajst-32496	145	19	at	at	ADP
ajst-32496	145	20	the	the	DET
ajst-32496	145	21	antwerp	antwerp	PROPN
ajst-32496	145	22	base	base	NOUN
ajst-32496	145	23	in	in	ADP
ajst-32496	145	24	belgium	belgium	NOUN
ajst-32496	145	25	by	by	ADP
ajst-32496	145	26	2026	2026	NUM
ajst-32496	145	27	.	.	PUNCT
ajst-32496	146	1	4	4	X
ajst-32496	146	2	.	.	X
ajst-32496	146	3	remaining	remain	VERB
ajst-32496	146	4	issues	issue	NOUN
ajst-32496	146	5	and	and	CCONJ
ajst-32496	146	6	future	future	ADJ
ajst-32496	146	7	development	development	NOUN
ajst-32496	146	8	prospects	prospect	NOUN
ajst-32496	146	9	these	these	DET
ajst-32496	146	10	improvement	improvement	NOUN
ajst-32496	146	11	methods	method	NOUN
ajst-32496	146	12	have	have	VERB
ajst-32496	146	13	,	,	PUNCT
ajst-32496	146	14	to	to	ADP
ajst-32496	146	15	some	some	DET
ajst-32496	146	16	extent	extent	NOUN
ajst-32496	146	17	,	,	PUNCT
ajst-32496	146	18	optimised	optimise	VERB
ajst-32496	146	19	the	the	DET
ajst-32496	146	20	technology	technology	NOUN
ajst-32496	146	21	for	for	ADP
ajst-32496	146	22	the	the	DET
ajst-32496	146	23	synthesis	synthesis	NOUN
ajst-32496	146	24	of	of	ADP
ajst-32496	146	25	sulphanilamide	sulphanilamide	NOUN
ajst-32496	146	26	and	and	CCONJ
ajst-32496	146	27	achieved	achieve	VERB
ajst-32496	146	28	certain	certain	ADJ
ajst-32496	146	29	results	result	NOUN
ajst-32496	146	30	.	.	PUNCT
ajst-32496	147	1	however	however	ADV
ajst-32496	147	2	,	,	PUNCT
ajst-32496	147	3	there	there	PRON
ajst-32496	147	4	are	be	VERB
ajst-32496	147	5	still	still	ADV
ajst-32496	147	6	some	some	DET
ajst-32496	147	7	issues	issue	NOUN
ajst-32496	147	8	that	that	PRON
ajst-32496	147	9	need	need	VERB
ajst-32496	147	10	to	to	PART
ajst-32496	147	11	be	be	AUX
ajst-32496	147	12	addressed	address	VERB
ajst-32496	147	13	urgently	urgently	ADV
ajst-32496	147	14	.	.	PUNCT
ajst-32496	148	1	in	in	ADP
ajst-32496	148	2	terms	term	NOUN
ajst-32496	148	3	of	of	ADP
ajst-32496	148	4	equipment	equipment	NOUN
ajst-32496	148	5	and	and	CCONJ
ajst-32496	148	6	technology	technology	NOUN
ajst-32496	148	7	,	,	PUNCT
ajst-32496	148	8	the	the	DET
ajst-32496	148	9	continuous	continuous	ADJ
ajst-32496	148	10	flow	flow	NOUN
ajst-32496	148	11	electrochemical	electrochemical	ADJ
ajst-32496	148	12	reactor	reactor	NOUN
ajst-32496	148	13	lacks	lack	VERB
ajst-32496	148	14	unified	unified	ADJ
ajst-32496	148	15	industry	industry	NOUN
ajst-32496	148	16	standards	standard	NOUN
ajst-32496	148	17	,	,	PUNCT
ajst-32496	148	18	which	which	PRON
ajst-32496	148	19	increases	increase	VERB
ajst-32496	148	20	the	the	DET
ajst-32496	148	21	risk	risk	NOUN
ajst-32496	148	22	of	of	ADP
ajst-32496	148	23	scaling	scale	VERB
ajst-32496	148	24	up	up	ADP
ajst-32496	148	25	the	the	DET
ajst-32496	148	26	process	process	NOUN
ajst-32496	148	27	.	.	PUNCT
ajst-32496	149	1	furthermore	furthermore	ADV
ajst-32496	149	2	,	,	PUNCT
ajst-32496	149	3	the	the	DET
ajst-32496	149	4	development	development	NOUN
ajst-32496	149	5	and	and	CCONJ
ajst-32496	149	6	operation	operation	NOUN
ajst-32496	149	7	of	of	ADP
ajst-32496	149	8	the	the	DET
ajst-32496	149	9	system	system	NOUN
ajst-32496	149	10	require	require	VERB
ajst-32496	149	11	highly	highly	ADV
ajst-32496	149	12	skilled	skilled	ADJ
ajst-32496	149	13	professionals	professional	NOUN
ajst-32496	149	14	who	who	PRON
ajst-32496	149	15	are	be	AUX
ajst-32496	149	16	proficient	proficient	ADJ
ajst-32496	149	17	in	in	ADP
ajst-32496	149	18	organic	organic	ADJ
ajst-32496	149	19	synthesis	synthesis	NOUN
ajst-32496	149	20	,	,	PUNCT
ajst-32496	149	21	electrochemistry	electrochemistry	NOUN
ajst-32496	149	22	,	,	PUNCT
ajst-32496	149	23	and	and	CCONJ
ajst-32496	149	24	chemical	chemical	NOUN
ajst-32496	149	25	engineering	engineering	NOUN
ajst-32496	149	26	simultaneously	simultaneously	ADV
ajst-32496	149	27	.	.	PUNCT
ajst-32496	150	1	such	such	ADJ
ajst-32496	150	2	specialised	specialised	ADJ
ajst-32496	150	3	talents	talent	NOUN
ajst-32496	150	4	are	be	AUX
ajst-32496	150	5	relatively	relatively	ADV
ajst-32496	150	6	scarce	scarce	ADJ
ajst-32496	150	7	.	.	PUNCT
ajst-32496	151	1	the	the	DET
ajst-32496	151	2	design	design	NOUN
ajst-32496	151	3	of	of	ADP
ajst-32496	151	4	a	a	DET
ajst-32496	151	5	complete	complete	ADJ
ajst-32496	151	6	continuous	continuous	ADJ
ajst-32496	151	7	-	-	PUNCT
ajst-32496	151	8	flow	flow	NOUN
ajst-32496	151	9	chemical	chemical	NOUN
ajst-32496	151	10	synthesis	synthesis	NOUN
ajst-32496	151	11	system	system	NOUN
ajst-32496	151	12	involves	involve	VERB
ajst-32496	151	13	many	many	ADJ
ajst-32496	151	14	components	component	NOUN
ajst-32496	151	15	.	.	PUNCT
ajst-32496	152	1	ensuring	ensure	VERB
ajst-32496	152	2	the	the	DET
ajst-32496	152	3	efficient	efficient	ADJ
ajst-32496	152	4	and	and	CCONJ
ajst-32496	152	5	accurate	accurate	ADJ
ajst-32496	152	6	operation	operation	NOUN
ajst-32496	152	7	of	of	ADP
ajst-32496	152	8	their	their	PRON
ajst-32496	152	9	systems	system	NOUN
ajst-32496	152	10	is	be	AUX
ajst-32496	152	11	also	also	ADV
ajst-32496	152	12	a	a	DET
ajst-32496	152	13	crucial	crucial	ADJ
ajst-32496	152	14	consideration	consideration	NOUN
ajst-32496	152	15	for	for	ADP
ajst-32496	152	16	production	production	NOUN
ajst-32496	152	17	companies	company	NOUN
ajst-32496	152	18	.	.	PUNCT
ajst-32496	153	1	at	at	ADP
ajst-32496	153	2	the	the	DET
ajst-32496	153	3	practical	practical	ADJ
ajst-32496	153	4	production	production	NOUN
ajst-32496	153	5	level	level	NOUN
ajst-32496	153	6	,	,	PUNCT
ajst-32496	153	7	the	the	DET
ajst-32496	153	8	initial	initial	ADJ
ajst-32496	153	9	investment	investment	NOUN
ajst-32496	153	10	of	of	ADP
ajst-32496	153	11	the	the	DET
ajst-32496	153	12	new	new	ADJ
ajst-32496	153	13	method	method	NOUN
ajst-32496	153	14	is	be	AUX
ajst-32496	153	15	high	high	ADJ
ajst-32496	153	16	.	.	PUNCT
ajst-32496	154	1	the	the	DET
ajst-32496	154	2	original	original	ADJ
ajst-32496	154	3	investment	investment	NOUN
ajst-32496	154	4	in	in	ADP
ajst-32496	154	5	equipment	equipment	NOUN
ajst-32496	154	6	,	,	PUNCT
ajst-32496	154	7	such	such	ADJ
ajst-32496	154	8	as	as	ADP
ajst-32496	154	9	sophisticated	sophisticated	ADJ
ajst-32496	154	10	continuous	continuous	ADJ
ajst-32496	154	11	reaction	reaction	NOUN
ajst-32496	154	12	flow	flow	NOUN
ajst-32496	154	13	instruments	instrument	NOUN
ajst-32496	154	14	and	and	CCONJ
ajst-32496	154	15	highprecision	highprecision	NOUN
ajst-32496	154	16	pumps	pump	NOUN
ajst-32496	154	17	,	,	PUNCT
ajst-32496	154	18	is	be	AUX
ajst-32496	154	19	significantly	significantly	ADV
ajst-32496	154	20	higher	high	ADJ
ajst-32496	154	21	than	than	ADP
ajst-32496	154	22	that	that	PRON
ajst-32496	154	23	of	of	ADP
ajst-32496	154	24	traditional	traditional	ADJ
ajst-32496	154	25	glass	glass	NOUN
ajst-32496	154	26	reaction	reaction	NOUN
ajst-32496	154	27	vessels	vessel	NOUN
ajst-32496	154	28	.	.	PUNCT
ajst-32496	155	1	moreover	moreover	ADV
ajst-32496	155	2	,	,	PUNCT
ajst-32496	155	3	for	for	ADP
ajst-32496	155	4	mature	mature	ADJ
ajst-32496	155	5	pharmaceutical	pharmaceutical	NOUN
ajst-32496	155	6	production	production	NOUN
ajst-32496	155	7	,	,	PUNCT
ajst-32496	155	8	the	the	DET
ajst-32496	155	9	traditional	traditional	ADJ
ajst-32496	155	10	process	process	NOUN
ajst-32496	155	11	is	be	AUX
ajst-32496	155	12	cost	cost	NOUN
ajst-32496	155	13	-	-	PUNCT
ajst-32496	155	14	effective	effective	ADJ
ajst-32496	155	15	and	and	CCONJ
ajst-32496	155	16	stable	stable	ADJ
ajst-32496	155	17	.	.	PUNCT
ajst-32496	156	1	the	the	DET
ajst-32496	156	2	introduction	introduction	NOUN
ajst-32496	156	3	of	of	ADP
ajst-32496	156	4	new	new	ADJ
ajst-32496	156	5	technologies	technology	NOUN
ajst-32496	156	6	needs	need	VERB
ajst-32496	156	7	to	to	PART
ajst-32496	156	8	be	be	AUX
ajst-32496	156	9	evaluated	evaluate	VERB
ajst-32496	156	10	to	to	PART
ajst-32496	156	11	determine	determine	VERB
ajst-32496	156	12	if	if	SCONJ
ajst-32496	156	13	it	it	PRON
ajst-32496	156	14	can	can	AUX
ajst-32496	156	15	enhance	enhance	VERB
ajst-32496	156	16	market	market	NOUN
ajst-32496	156	17	competitiveness	competitiveness	NOUN
ajst-32496	156	18	,	,	PUNCT
ajst-32496	156	19	and	and	CCONJ
ajst-32496	156	20	the	the	DET
ajst-32496	156	21	investment	investment	NOUN
ajst-32496	156	22	return	return	NOUN
ajst-32496	156	23	period	period	NOUN
ajst-32496	156	24	is	be	AUX
ajst-32496	156	25	uncertain	uncertain	ADJ
ajst-32496	156	26	.	.	PUNCT
ajst-32496	157	1	based	base	VERB
ajst-32496	157	2	on	on	ADP
ajst-32496	157	3	the	the	DET
ajst-32496	157	4	above	above	ADJ
ajst-32496	157	5	issues	issue	NOUN
ajst-32496	157	6	,	,	PUNCT
ajst-32496	157	7	we	we	PRON
ajst-32496	157	8	considered	consider	VERB
ajst-32496	157	9	that	that	SCONJ
ajst-32496	157	10	,	,	PUNCT
ajst-32496	157	11	first	first	ADV
ajst-32496	157	12	of	of	ADP
ajst-32496	157	13	all	all	PRON
ajst-32496	157	14	,	,	PUNCT
ajst-32496	157	15	standardised	standardised	ADJ
ajst-32496	157	16	and	and	CCONJ
ajst-32496	157	17	modularised	modularise	VERB
ajst-32496	157	18	reaction	reaction	NOUN
ajst-32496	157	19	components	component	NOUN
ajst-32496	157	20	can	can	AUX
ajst-32496	157	21	be	be	AUX
ajst-32496	157	22	developed	develop	VERB
ajst-32496	157	23	in	in	ADP
ajst-32496	157	24	the	the	DET
ajst-32496	157	25	future	future	NOUN
ajst-32496	157	26	to	to	PART
ajst-32496	157	27	lower	lower	VERB
ajst-32496	157	28	the	the	DET
ajst-32496	157	29	usage	usage	NOUN
ajst-32496	157	30	threshold	threshold	NOUN
ajst-32496	157	31	.	.	PUNCT
ajst-32496	158	1	secondly	secondly	ADV
ajst-32496	158	2	,	,	PUNCT
ajst-32496	158	3	it	it	PRON
ajst-32496	158	4	is	be	AUX
ajst-32496	158	5	advisable	advisable	ADJ
ajst-32496	158	6	to	to	PART
ajst-32496	158	7	combine	combine	VERB
ajst-32496	158	8	with	with	ADP
ajst-32496	158	9	artificial	artificial	ADJ
ajst-32496	158	10	intelligence	intelligence	NOUN
ajst-32496	158	11	technology	technology	NOUN
ajst-32496	158	12	.	.	PUNCT
ajst-32496	159	1	by	by	ADP
ajst-32496	159	2	using	use	VERB
ajst-32496	159	3	artificial	artificial	ADJ
ajst-32496	159	4	intelligence	intelligence	NOUN
ajst-32496	159	5	to	to	PART
ajst-32496	159	6	learn	learn	VERB
ajst-32496	159	7	from	from	ADP
ajst-32496	159	8	the	the	DET
ajst-32496	159	9	research	research	NOUN
ajst-32496	159	10	data	datum	NOUN
ajst-32496	159	11	,	,	PUNCT
ajst-32496	159	12	predict	predict	VERB
ajst-32496	159	13	reaction	reaction	NOUN
ajst-32496	159	14	conditions	condition	NOUN
ajst-32496	159	15	,	,	PUNCT
ajst-32496	159	16	and	and	CCONJ
ajst-32496	159	17	optimise	optimise	VERB
ajst-32496	159	18	the	the	DET
ajst-32496	159	19	reaction	reaction	NOUN
ajst-32496	159	20	process	process	NOUN
ajst-32496	159	21	.	.	PUNCT
ajst-32496	160	1	thirdly	thirdly	ADV
ajst-32496	160	2	,	,	PUNCT
ajst-32496	160	3	interdisciplinary	interdisciplinary	ADJ
ajst-32496	160	4	technological	technological	ADJ
ajst-32496	160	5	integration	integration	NOUN
ajst-32496	160	6	can	can	AUX
ajst-32496	160	7	be	be	AUX
ajst-32496	160	8	carried	carry	VERB
ajst-32496	160	9	out	out	ADP
ajst-32496	160	10	.	.	PUNCT
ajst-32496	161	1	for	for	ADP
ajst-32496	161	2	instance	instance	NOUN
ajst-32496	161	3	,	,	PUNCT
ajst-32496	161	4	considering	consider	VERB
ajst-32496	161	5	the	the	DET
ajst-32496	161	6	combination	combination	NOUN
ajst-32496	161	7	of	of	ADP
ajst-32496	161	8	electrochemistry	electrochemistry	NOUN
ajst-32496	161	9	,	,	PUNCT
ajst-32496	161	10	photochemistry	photochemistry	NOUN
ajst-32496	161	11	,	,	PUNCT
ajst-32496	161	12	and	and	CCONJ
ajst-32496	161	13	biochemistry	biochemistry	NOUN
ajst-32496	161	14	(	(	PUNCT
ajst-32496	161	15	enzyme	enzyme	NOUN
ajst-32496	161	16	catalysis	catalysis	NOUN
ajst-32496	161	17	)	)	PUNCT
ajst-32496	161	18	technologies	technology	NOUN
ajst-32496	161	19	could	could	AUX
ajst-32496	161	20	be	be	AUX
ajst-32496	161	21	a	a	DET
ajst-32496	161	22	possible	possible	ADJ
ajst-32496	161	23	research	research	NOUN
ajst-32496	161	24	direction	direction	NOUN
ajst-32496	161	25	.	.	PUNCT
ajst-32496	162	1	this	this	PRON
ajst-32496	162	2	might	might	AUX
ajst-32496	162	3	break	break	VERB
ajst-32496	162	4	through	through	ADP
ajst-32496	162	5	the	the	DET
ajst-32496	162	6	limitations	limitation	NOUN
ajst-32496	162	7	of	of	ADP
ajst-32496	162	8	traditional	traditional	ADJ
ajst-32496	162	9	reaction	reaction	NOUN
ajst-32496	162	10	pathways	pathway	NOUN
ajst-32496	162	11	and	and	CCONJ
ajst-32496	162	12	enable	enable	VERB
ajst-32496	162	13	efficient	efficient	ADJ
ajst-32496	162	14	synthesis	synthesis	NOUN
ajst-32496	162	15	.	.	PUNCT
ajst-32496	163	1	5	5	X
ajst-32496	163	2	.	.	X
ajst-32496	163	3	conclusion	conclusion	NOUN
ajst-32496	163	4	this	this	DET
ajst-32496	163	5	study	study	NOUN
ajst-32496	163	6	reviewed	review	VERB
ajst-32496	163	7	the	the	DET
ajst-32496	163	8	synthesis	synthesis	NOUN
ajst-32496	163	9	process	process	NOUN
ajst-32496	163	10	of	of	ADP
ajst-32496	163	11	sulphonamide	sulphonamide	NOUN
ajst-32496	163	12	and	and	CCONJ
ajst-32496	163	13	evaluated	evaluate	VERB
ajst-32496	163	14	emerging	emerge	VERB
ajst-32496	163	15	strategies	strategy	NOUN
ajst-32496	163	16	for	for	ADP
ajst-32496	163	17	improving	improve	VERB
ajst-32496	163	18	its	its	PRON
ajst-32496	163	19	production	production	NOUN
ajst-32496	163	20	efficiency	efficiency	NOUN
ajst-32496	163	21	and	and	CCONJ
ajst-32496	163	22	sustainability	sustainability	NOUN
ajst-32496	163	23	.	.	PUNCT
ajst-32496	164	1	traditional	traditional	ADJ
ajst-32496	164	2	multi	multi	ADJ
ajst-32496	164	3	-	-	ADJ
ajst-32496	164	4	step	step	ADJ
ajst-32496	164	5	synthesis	synthesis	NOUN
ajst-32496	164	6	methods	method	NOUN
ajst-32496	164	7	,	,	PUNCT
ajst-32496	164	8	while	while	SCONJ
ajst-32496	164	9	chemically	chemically	ADV
ajst-32496	164	10	robust	robust	ADJ
ajst-32496	164	11	,	,	PUNCT
ajst-32496	164	12	are	be	AUX
ajst-32496	164	13	hindered	hinder	VERB
ajst-32496	164	14	by	by	ADP
ajst-32496	164	15	high	high	ADJ
ajst-32496	164	16	costs	cost	NOUN
ajst-32496	164	17	,	,	PUNCT
ajst-32496	164	18	energy	energy	NOUN
ajst-32496	164	19	consumption	consumption	NOUN
ajst-32496	164	20	,	,	PUNCT
ajst-32496	164	21	and	and	CCONJ
ajst-32496	164	22	environmental	environmental	ADJ
ajst-32496	164	23	impact	impact	NOUN
ajst-32496	164	24	.	.	PUNCT
ajst-32496	165	1	contemporary	contemporary	ADJ
ajst-32496	165	2	techniques	technique	NOUN
ajst-32496	165	3	—	—	PUNCT
ajst-32496	165	4	such	such	ADJ
ajst-32496	165	5	as	as	ADP
ajst-32496	165	6	continuous	continuous	ADJ
ajst-32496	165	7	flow	flow	NOUN
ajst-32496	165	8	technology	technology	NOUN
ajst-32496	165	9	,	,	PUNCT
ajst-32496	165	10	green	green	ADJ
ajst-32496	165	11	chemistry	chemistry	NOUN
ajst-32496	165	12	principles	principle	NOUN
ajst-32496	165	13	,	,	PUNCT
ajst-32496	165	14	and	and	CCONJ
ajst-32496	165	15	electrochemical	electrochemical	ADJ
ajst-32496	165	16	synthesis	synthesis	NOUN
ajst-32496	165	17	—	—	PUNCT
ajst-32496	165	18	offer	offer	VERB
ajst-32496	165	19	viable	viable	ADJ
ajst-32496	165	20	pathways	pathway	NOUN
ajst-32496	165	21	to	to	PART
ajst-32496	165	22	address	address	VERB
ajst-32496	165	23	these	these	DET
ajst-32496	165	24	limitations	limitation	NOUN
ajst-32496	165	25	by	by	ADP
ajst-32496	165	26	enhancing	enhance	VERB
ajst-32496	165	27	yield	yield	NOUN
ajst-32496	165	28	,	,	PUNCT
ajst-32496	165	29	minimizing	minimize	VERB
ajst-32496	165	30	waste	waste	NOUN
ajst-32496	165	31	,	,	PUNCT
ajst-32496	165	32	and	and	CCONJ
ajst-32496	165	33	reducing	reduce	VERB
ajst-32496	165	34	hazardous	hazardous	ADJ
ajst-32496	165	35	by	by	ADP
ajst-32496	165	36	-	-	PUNCT
ajst-32496	165	37	products	product	NOUN
ajst-32496	165	38	.	.	PUNCT
ajst-32496	166	1	however	however	ADV
ajst-32496	166	2	,	,	PUNCT
ajst-32496	166	3	challenges	challenge	NOUN
ajst-32496	166	4	remain	remain	VERB
ajst-32496	166	5	in	in	ADP
ajst-32496	166	6	terms	term	NOUN
ajst-32496	166	7	of	of	ADP
ajst-32496	166	8	industrial	industrial	ADJ
ajst-32496	166	9	scalability	scalability	NOUN
ajst-32496	166	10	,	,	PUNCT
ajst-32496	166	11	equipment	equipment	NOUN
ajst-32496	166	12	investment	investment	NOUN
ajst-32496	166	13	,	,	PUNCT
ajst-32496	166	14	and	and	CCONJ
ajst-32496	166	15	cross	cross	ADJ
ajst-32496	166	16	-	-	ADJ
ajst-32496	166	17	disciplinary	disciplinary	ADJ
ajst-32496	166	18	integration	integration	NOUN
ajst-32496	166	19	.	.	PUNCT
ajst-32496	167	1	future	future	ADJ
ajst-32496	167	2	research	research	NOUN
ajst-32496	167	3	should	should	AUX
ajst-32496	167	4	focus	focus	VERB
ajst-32496	167	5	on	on	ADP
ajst-32496	167	6	developing	develop	VERB
ajst-32496	167	7	standardized	standardize	VERB
ajst-32496	167	8	,	,	PUNCT
ajst-32496	167	9	automated	automate	VERB
ajst-32496	167	10	,	,	PUNCT
ajst-32496	167	11	and	and	CCONJ
ajst-32496	167	12	ai	ai	ADJ
ajst-32496	167	13	-	-	PUNCT
ajst-32496	167	14	assisted	assist	VERB
ajst-32496	167	15	synthesis	synthesis	NOUN
ajst-32496	167	16	platforms	platform	NOUN
ajst-32496	167	17	that	that	PRON
ajst-32496	167	18	combine	combine	VERB
ajst-32496	167	19	precision	precision	NOUN
ajst-32496	167	20	,	,	PUNCT
ajst-32496	167	21	safety	safety	NOUN
ajst-32496	167	22	,	,	PUNCT
ajst-32496	167	23	and	and	CCONJ
ajst-32496	167	24	sustainability	sustainability	NOUN
ajst-32496	167	25	,	,	PUNCT
ajst-32496	167	26	ensuring	ensure	VERB
ajst-32496	167	27	that	that	SCONJ
ajst-32496	167	28	sulphonamide	sulphonamide	PROPN
ajst-32496	167	29	production	production	NOUN
ajst-32496	167	30	evolves	evolve	NOUN
ajst-32496	167	31	toward	toward	ADP
ajst-32496	167	32	environmentally	environmentally	ADV
ajst-32496	167	33	responsible	responsible	ADJ
ajst-32496	167	34	and	and	CCONJ
ajst-32496	167	35	economically	economically	ADV
ajst-32496	167	36	feasible	feasible	ADJ
ajst-32496	167	37	industrial	industrial	ADJ
ajst-32496	167	38	applications	application	NOUN
ajst-32496	167	39	.	.	PUNCT
ajst-32496	168	1	144	144	NUM
ajst-32496	168	2	acknowledgments	acknowledgment	NOUN
ajst-32496	168	3	thank	thank	VERB
ajst-32496	168	4	the	the	DET
ajst-32496	168	5	instructor	instructor	NOUN
ajst-32496	168	6	,	,	PUNCT
ajst-32496	168	7	wang	wang	PROPN
ajst-32496	168	8	yiwei	yiwei	PROPN
ajst-32496	168	9	,	,	PUNCT
ajst-32496	168	10	for	for	ADP
ajst-32496	168	11	her	her	PRON
ajst-32496	168	12	guidance	guidance	NOUN
ajst-32496	168	13	throughout	throughout	ADP
ajst-32496	168	14	the	the	DET
ajst-32496	168	15	research	research	NOUN
ajst-32496	168	16	process	process	NOUN
ajst-32496	168	17	and	and	CCONJ
ajst-32496	168	18	for	for	ADP
ajst-32496	168	19	her	her	PRON
ajst-32496	168	20	assistance	assistance	NOUN
ajst-32496	168	21	during	during	ADP
ajst-32496	168	22	the	the	DET
ajst-32496	168	23	experiment	experiment	NOUN
ajst-32496	168	24	.	.	PUNCT
ajst-32496	169	1	her	her	PRON
ajst-32496	169	2	guidance	guidance	NOUN
ajst-32496	169	3	was	be	AUX
ajst-32496	169	4	of	of	ADP
ajst-32496	169	5	great	great	ADJ
ajst-32496	169	6	help	help	NOUN
ajst-32496	169	7	in	in	ADP
ajst-32496	169	8	determining	determine	VERB
ajst-32496	169	9	the	the	DET
ajst-32496	169	10	research	research	NOUN
ajst-32496	169	11	direction	direction	NOUN
ajst-32496	169	12	of	of	ADP
ajst-32496	169	13	this	this	DET
ajst-32496	169	14	article	article	NOUN
ajst-32496	169	15	for	for	ADP
ajst-32496	169	16	us	we	PRON
ajst-32496	169	17	,	,	PUNCT
ajst-32496	169	18	and	and	CCONJ
ajst-32496	169	19	it	it	PRON
ajst-32496	169	20	also	also	ADV
ajst-32496	169	21	provided	provide	VERB
ajst-32496	169	22	an	an	DET
ajst-32496	169	23	important	important	ADJ
ajst-32496	169	24	theoretical	theoretical	ADJ
ajst-32496	169	25	foundation	foundation	NOUN
ajst-32496	169	26	for	for	ADP
ajst-32496	169	27	this	this	DET
ajst-32496	169	28	study	study	NOUN
ajst-32496	169	29	.	.	PUNCT
ajst-32496	170	1	references	reference	NOUN
ajst-32496	170	2	[	[	X
ajst-32496	170	3	1	1	NUM
ajst-32496	170	4	]	]	PUNCT
ajst-32496	170	5	atapalkar	atapalkar	ADJ
ajst-32496	170	6	,	,	PUNCT
ajst-32496	170	7	ranjit	ranjit	PROPN
ajst-32496	170	8	s.	s.	PROPN
ajst-32496	170	9	,	,	PUNCT
ajst-32496	170	10	and	and	CCONJ
ajst-32496	170	11	amol	amol	PROPN
ajst-32496	170	12	a.	a.	PROPN
ajst-32496	170	13	kulkarni	kulkarni	PROPN
ajst-32496	170	14	.	.	PUNCT
ajst-32496	171	1	“	"	PUNCT
ajst-32496	171	2	batch	batch	VERB
ajst-32496	171	3	and	and	CCONJ
ajst-32496	171	4	continuous	continuous	ADJ
ajst-32496	171	5	flow	flow	NOUN
ajst-32496	171	6	mechanochemical	mechanochemical	ADJ
ajst-32496	171	7	synthesis	synthesis	NOUN
ajst-32496	171	8	of	of	ADP
ajst-32496	171	9	organic	organic	ADJ
ajst-32496	171	10	compounds	compound	NOUN
ajst-32496	171	11	,	,	PUNCT
ajst-32496	171	12	including	include	VERB
ajst-32496	171	13	apis	apis	PROPN
ajst-32496	171	14	.	.	PUNCT
ajst-32496	171	15	”	"	PUNCT
ajst-32496	172	1	reaction	reaction	NOUN
ajst-32496	172	2	chemistry	chemistry	PROPN
ajst-32496	172	3	&	&	CCONJ
ajst-32496	172	4	amp	amp	PROPN
ajst-32496	172	5	;	;	PUNCT
ajst-32496	172	6	engineering	engineering	NOUN
ajst-32496	172	7	,	,	PUNCT
ajst-32496	172	8	vol	vol	NOUN
ajst-32496	172	9	.	.	PROPN
ajst-32496	172	10	9	9	NUM
ajst-32496	172	11	,	,	PUNCT
ajst-32496	172	12	no	no	INTJ
ajst-32496	172	13	.	.	NOUN
ajst-32496	172	14	1	1	NUM
ajst-32496	172	15	,	,	PUNCT
ajst-32496	172	16	2024	2024	NUM
ajst-32496	172	17	,	,	PUNCT
ajst-32496	172	18	pp	pp	ADJ
ajst-32496	172	19	.	.	PUNCT
ajst-32496	173	1	10–25	10–25	NUM
ajst-32496	173	2	,	,	PUNCT
ajst-32496	173	3	https://doi.org/10.1039/d2re00521b	https://doi.org/10.1039/d2re00521b	PROPN
ajst-32496	173	4	.	.	PUNCT
ajst-32496	174	1	[	[	X
ajst-32496	174	2	2	2	NUM
ajst-32496	174	3	]	]	SYM
ajst-32496	174	4	yu	yu	PROPN
ajst-32496	174	5	,	,	PUNCT
ajst-32496	174	6	m.	m.	NOUN
ajst-32496	174	7	,	,	PUNCT
ajst-32496	174	8	strotman	strotman	NOUN
ajst-32496	174	9	,	,	PUNCT
ajst-32496	174	10	n.	n.	NOUN
ajst-32496	174	11	a.	a.	NOUN
ajst-32496	174	12	,	,	PUNCT
ajst-32496	174	13	savage	savage	NOUN
ajst-32496	174	14	,	,	PUNCT
ajst-32496	174	15	s.	s.	PROPN
ajst-32496	174	16	a.	a.	PROPN
ajst-32496	174	17	,	,	PUNCT
ajst-32496	174	18	leung	leung	PROPN
ajst-32496	174	19	,	,	PUNCT
ajst-32496	174	20	s.	s.	PROPN
ajst-32496	174	21	,	,	PUNCT
ajst-32496	174	22	&	&	CCONJ
ajst-32496	174	23	ramirez	ramirez	PROPN
ajst-32496	174	24	,	,	PUNCT
ajst-32496	174	25	a.	a.	NOUN
ajst-32496	174	26	(	(	PUNCT
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