id	sid	tid	token	lemma	pos
ajst-32569	1	1	163	163	NUM
ajst-32569	1	2	review	review	NOUN
ajst-32569	1	3	on	on	ADP
ajst-32569	1	4	neurophysiological	neurophysiological	ADJ
ajst-32569	1	5	mechanisms	mechanism	NOUN
ajst-32569	1	6	of	of	ADP
ajst-32569	1	7	depression	depression	PROPN
ajst-32569	1	8	zehong	zehong	PROPN
ajst-32569	1	9	xuan	xuan	PROPN
ajst-32569	1	10	university	university	PROPN
ajst-32569	1	11	of	of	ADP
ajst-32569	1	12	connecticut	connecticut	PROPN
ajst-32569	1	13	,	,	PUNCT
ajst-32569	1	14	352	352	NUM
ajst-32569	1	15	mansfield	mansfield	PROPN
ajst-32569	1	16	rd	rd	PROPN
ajst-32569	1	17	,	,	PUNCT
ajst-32569	1	18	storrs	storrs	PROPN
ajst-32569	1	19	,	,	PUNCT
ajst-32569	1	20	ct	ct	PROPN
ajst-32569	1	21	,	,	PUNCT
ajst-32569	1	22	06269	06269	NUM
ajst-32569	1	23	,	,	PUNCT
ajst-32569	1	24	usa	usa	PROPN
ajst-32569	1	25	zehongxuan0107@gmail.com	zehongxuan0107@gmail.com	PROPN
ajst-32569	1	26	abstract	abstract	PROPN
ajst-32569	1	27	.	.	PUNCT
ajst-32569	2	1	depression	depression	NOUN
ajst-32569	2	2	is	be	AUX
ajst-32569	2	3	a	a	DET
ajst-32569	2	4	common	common	ADJ
ajst-32569	2	5	and	and	CCONJ
ajst-32569	2	6	highly	highly	ADV
ajst-32569	2	7	disabling	disable	VERB
ajst-32569	2	8	mental	mental	ADJ
ajst-32569	2	9	disorder	disorder	NOUN
ajst-32569	2	10	,	,	PUNCT
ajst-32569	2	11	whose	whose	DET
ajst-32569	2	12	complex	complex	ADJ
ajst-32569	2	13	neurophysiological	neurophysiological	ADJ
ajst-32569	2	14	mechanisms	mechanism	NOUN
ajst-32569	2	15	have	have	AUX
ajst-32569	2	16	not	not	PART
ajst-32569	2	17	been	be	AUX
ajst-32569	2	18	fully	fully	ADV
ajst-32569	2	19	elucidated	elucidated	ADJ
ajst-32569	2	20	.	.	PUNCT
ajst-32569	3	1	although	although	SCONJ
ajst-32569	3	2	the	the	DET
ajst-32569	3	3	traditional	traditional	ADJ
ajst-32569	3	4	monoaminergic	monoaminergic	ADJ
ajst-32569	3	5	neurotransmitter	neurotransmitter	NOUN
ajst-32569	3	6	hypothesis	hypothesis	NOUN
ajst-32569	3	7	laid	lay	VERB
ajst-32569	3	8	the	the	DET
ajst-32569	3	9	foundation	foundation	NOUN
ajst-32569	3	10	for	for	ADP
ajst-32569	3	11	drug	drug	NOUN
ajst-32569	3	12	therapy	therapy	NOUN
ajst-32569	3	13	,	,	PUNCT
ajst-32569	3	14	it	it	PRON
ajst-32569	3	15	fails	fail	VERB
ajst-32569	3	16	to	to	PART
ajst-32569	3	17	explain	explain	VERB
ajst-32569	3	18	all	all	DET
ajst-32569	3	19	its	its	PRON
ajst-32569	3	20	pathological	pathological	ADJ
ajst-32569	3	21	phenomena	phenomenon	NOUN
ajst-32569	3	22	.	.	PUNCT
ajst-32569	4	1	in	in	ADP
ajst-32569	4	2	recent	recent	ADJ
ajst-32569	4	3	years	year	NOUN
ajst-32569	4	4	,	,	PUNCT
ajst-32569	4	5	with	with	ADP
ajst-32569	4	6	the	the	DET
ajst-32569	4	7	development	development	NOUN
ajst-32569	4	8	of	of	ADP
ajst-32569	4	9	neuroimaging	neuroimaging	NOUN
ajst-32569	4	10	and	and	CCONJ
ajst-32569	4	11	molecular	molecular	ADJ
ajst-32569	4	12	biology	biology	NOUN
ajst-32569	4	13	techniques	technique	NOUN
ajst-32569	4	14	,	,	PUNCT
ajst-32569	4	15	research	research	NOUN
ajst-32569	4	16	has	have	AUX
ajst-32569	4	17	gradually	gradually	ADV
ajst-32569	4	18	delved	delve	VERB
ajst-32569	4	19	into	into	ADP
ajst-32569	4	20	multiple	multiple	ADJ
ajst-32569	4	21	levels	level	NOUN
ajst-32569	4	22	such	such	ADJ
ajst-32569	4	23	as	as	ADP
ajst-32569	4	24	neural	neural	ADJ
ajst-32569	4	25	circuits	circuit	NOUN
ajst-32569	4	26	,	,	PUNCT
ajst-32569	4	27	brain	brain	NOUN
ajst-32569	4	28	structure	structure	NOUN
ajst-32569	4	29	,	,	PUNCT
ajst-32569	4	30	and	and	CCONJ
ajst-32569	4	31	the	the	DET
ajst-32569	4	32	immune	immune	ADJ
ajst-32569	4	33	system	system	NOUN
ajst-32569	4	34	.	.	PUNCT
ajst-32569	5	1	this	this	DET
ajst-32569	5	2	review	review	NOUN
ajst-32569	5	3	aims	aim	VERB
ajst-32569	5	4	to	to	PART
ajst-32569	5	5	systematically	systematically	ADV
ajst-32569	5	6	organize	organize	VERB
ajst-32569	5	7	the	the	DET
ajst-32569	5	8	current	current	ADJ
ajst-32569	5	9	mainstream	mainstream	NOUN
ajst-32569	5	10	research	research	NOUN
ajst-32569	5	11	directions	direction	NOUN
ajst-32569	5	12	on	on	ADP
ajst-32569	5	13	the	the	DET
ajst-32569	5	14	neurophysiological	neurophysiological	ADJ
ajst-32569	5	15	mechanisms	mechanism	NOUN
ajst-32569	5	16	of	of	ADP
ajst-32569	5	17	depression	depression	NOUN
ajst-32569	5	18	,	,	PUNCT
ajst-32569	5	19	focusing	focus	VERB
ajst-32569	5	20	on	on	ADP
ajst-32569	5	21	the	the	DET
ajst-32569	5	22	dysfunction	dysfunction	NOUN
ajst-32569	5	23	of	of	ADP
ajst-32569	5	24	the	the	DET
ajst-32569	5	25	prefrontal	prefrontal	ADJ
ajst-32569	5	26	-	-	PUNCT
ajst-32569	5	27	limbic	limbic	ADJ
ajst-32569	5	28	system	system	NOUN
ajst-32569	5	29	circuit	circuit	NOUN
ajst-32569	5	30	and	and	CCONJ
ajst-32569	5	31	its	its	PRON
ajst-32569	5	32	associated	associated	ADJ
ajst-32569	5	33	brain	brain	NOUN
ajst-32569	5	34	structural	structural	ADJ
ajst-32569	5	35	changes	change	NOUN
ajst-32569	5	36	,	,	PUNCT
ajst-32569	5	37	as	as	ADV
ajst-32569	5	38	well	well	ADV
ajst-32569	5	39	as	as	ADP
ajst-32569	5	40	the	the	DET
ajst-32569	5	41	central	central	ADJ
ajst-32569	5	42	role	role	NOUN
ajst-32569	5	43	of	of	ADP
ajst-32569	5	44	the	the	DET
ajst-32569	5	45	neuroinflammation	neuroinflammation	NOUN
ajst-32569	5	46	mechanism	mechanism	NOUN
ajst-32569	5	47	in	in	ADP
ajst-32569	5	48	the	the	DET
ajst-32569	5	49	development	development	NOUN
ajst-32569	5	50	of	of	ADP
ajst-32569	5	51	depression	depression	NOUN
ajst-32569	5	52	.	.	PUNCT
ajst-32569	6	1	through	through	ADP
ajst-32569	6	2	integration	integration	NOUN
ajst-32569	6	3	and	and	CCONJ
ajst-32569	6	4	analysis	analysis	NOUN
ajst-32569	6	5	of	of	ADP
ajst-32569	6	6	existing	exist	VERB
ajst-32569	6	7	literature	literature	NOUN
ajst-32569	6	8	,	,	PUNCT
ajst-32569	6	9	we	we	PRON
ajst-32569	6	10	propose	propose	VERB
ajst-32569	6	11	that	that	SCONJ
ajst-32569	6	12	depression	depression	NOUN
ajst-32569	6	13	is	be	AUX
ajst-32569	6	14	a	a	DET
ajst-32569	6	15	syndrome	syndrome	NOUN
ajst-32569	6	16	resulting	result	VERB
ajst-32569	6	17	from	from	ADP
ajst-32569	6	18	the	the	DET
ajst-32569	6	19	interaction	interaction	NOUN
ajst-32569	6	20	of	of	ADP
ajst-32569	6	21	genetic	genetic	ADJ
ajst-32569	6	22	susceptibility	susceptibility	NOUN
ajst-32569	6	23	and	and	CCONJ
ajst-32569	6	24	environmental	environmental	ADJ
ajst-32569	6	25	stress	stress	NOUN
ajst-32569	6	26	factors	factor	NOUN
ajst-32569	6	27	,	,	PUNCT
ajst-32569	6	28	leading	lead	VERB
ajst-32569	6	29	to	to	ADP
ajst-32569	6	30	neural	neural	ADJ
ajst-32569	6	31	circuit	circuit	NOUN
ajst-32569	6	32	dysfunction	dysfunction	NOUN
ajst-32569	6	33	,	,	PUNCT
ajst-32569	6	34	neurotrophic	neurotrophic	ADJ
ajst-32569	6	35	imbalance	imbalance	NOUN
ajst-32569	6	36	,	,	PUNCT
ajst-32569	6	37	and	and	CCONJ
ajst-32569	6	38	immune	immune	ADJ
ajst-32569	6	39	system	system	NOUN
ajst-32569	6	40	activation	activation	NOUN
ajst-32569	6	41	.	.	PUNCT
ajst-32569	7	1	a	a	DET
ajst-32569	7	2	deeper	deep	ADJ
ajst-32569	7	3	understanding	understanding	NOUN
ajst-32569	7	4	of	of	ADP
ajst-32569	7	5	future	future	ADJ
ajst-32569	7	6	mechanisms	mechanism	NOUN
ajst-32569	7	7	will	will	AUX
ajst-32569	7	8	provide	provide	VERB
ajst-32569	7	9	a	a	DET
ajst-32569	7	10	key	key	ADJ
ajst-32569	7	11	theoretical	theoretical	ADJ
ajst-32569	7	12	basis	basis	NOUN
ajst-32569	7	13	for	for	ADP
ajst-32569	7	14	developing	develop	VERB
ajst-32569	7	15	novel	novel	NOUN
ajst-32569	7	16	,	,	PUNCT
ajst-32569	7	17	fastacting	fastacte	VERB
ajst-32569	7	18	antidepressant	antidepressant	ADJ
ajst-32569	7	19	strategies	strategy	NOUN
ajst-32569	7	20	.	.	PUNCT
ajst-32569	8	1	keywords	keyword	NOUN
ajst-32569	8	2	:	:	PUNCT
ajst-32569	8	3	depression	depression	NOUN
ajst-32569	8	4	;	;	PUNCT
ajst-32569	8	5	neurophysiological	neurophysiological	ADJ
ajst-32569	8	6	mechanisms	mechanism	NOUN
ajst-32569	8	7	;	;	PUNCT
ajst-32569	8	8	prefrontal	prefrontal	ADJ
ajst-32569	8	9	-	-	PUNCT
ajst-32569	8	10	limbic	limbic	ADJ
ajst-32569	8	11	system	system	NOUN
ajst-32569	8	12	;	;	PUNCT
ajst-32569	8	13	brain	brain	NOUN
ajst-32569	8	14	structure	structure	NOUN
ajst-32569	8	15	;	;	PUNCT
ajst-32569	8	16	neuroinflammation	neuroinflammation	NOUN
ajst-32569	8	17	;	;	PUNCT
ajst-32569	8	18	bdnf	bdnf	PROPN
ajst-32569	8	19	.	.	PROPN
ajst-32569	9	1	1	1	X
ajst-32569	9	2	.	.	X
ajst-32569	9	3	introduction	introduction	NOUN
ajst-32569	9	4	major	major	ADJ
ajst-32569	9	5	depressive	depressive	ADJ
ajst-32569	9	6	disorder	disorder	NOUN
ajst-32569	9	7	(	(	PUNCT
ajst-32569	9	8	mdd	mdd	PROPN
ajst-32569	9	9	)	)	PUNCT
ajst-32569	9	10	is	be	AUX
ajst-32569	9	11	a	a	DET
ajst-32569	9	12	common	common	ADJ
ajst-32569	9	13	,	,	PUNCT
ajst-32569	9	14	recurrent	recurrent	NOUN
ajst-32569	9	15	,	,	PUNCT
ajst-32569	9	16	and	and	CCONJ
ajst-32569	9	17	highly	highly	ADV
ajst-32569	9	18	disabling	disable	VERB
ajst-32569	9	19	mental	mental	ADJ
ajst-32569	9	20	disorder	disorder	NOUN
ajst-32569	9	21	.	.	PUNCT
ajst-32569	10	1	its	its	PRON
ajst-32569	10	2	global	global	ADJ
ajst-32569	10	3	disease	disease	NOUN
ajst-32569	10	4	burden	burden	NOUN
ajst-32569	10	5	is	be	AUX
ajst-32569	10	6	heavy	heavy	ADJ
ajst-32569	10	7	,	,	PUNCT
ajst-32569	10	8	and	and	CCONJ
ajst-32569	10	9	according	accord	VERB
ajst-32569	10	10	to	to	ADP
ajst-32569	10	11	world	world	PROPN
ajst-32569	10	12	health	health	NOUN
ajst-32569	10	13	organization	organization	NOUN
ajst-32569	10	14	(	(	PUNCT
ajst-32569	10	15	who	who	PRON
ajst-32569	10	16	)	)	PUNCT
ajst-32569	10	17	statistics	statistic	NOUN
ajst-32569	10	18	,	,	PUNCT
ajst-32569	10	19	it	it	PRON
ajst-32569	10	20	is	be	AUX
ajst-32569	10	21	one	one	NUM
ajst-32569	10	22	of	of	ADP
ajst-32569	10	23	the	the	DET
ajst-32569	10	24	leading	lead	VERB
ajst-32569	10	25	causes	cause	NOUN
ajst-32569	10	26	of	of	ADP
ajst-32569	10	27	disability	disability	NOUN
ajst-32569	10	28	worldwide	worldwide	ADV
ajst-32569	11	1	[	[	X
ajst-32569	11	2	1	1	NUM
ajst-32569	11	3	]	]	PUNCT
ajst-32569	11	4	.	.	PUNCT
ajst-32569	12	1	its	its	PRON
ajst-32569	12	2	characteristic	characteristic	ADJ
ajst-32569	12	3	clinical	clinical	ADJ
ajst-32569	12	4	manifestations	manifestation	NOUN
ajst-32569	12	5	include	include	VERB
ajst-32569	12	6	persistent	persistent	ADJ
ajst-32569	12	7	low	low	ADJ
ajst-32569	12	8	mood	mood	NOUN
ajst-32569	12	9	,	,	PUNCT
ajst-32569	12	10	loss	loss	NOUN
ajst-32569	12	11	of	of	ADP
ajst-32569	12	12	interest	interest	NOUN
ajst-32569	12	13	,	,	PUNCT
ajst-32569	12	14	impaired	impaired	ADJ
ajst-32569	12	15	cognitive	cognitive	ADJ
ajst-32569	12	16	function	function	NOUN
ajst-32569	12	17	(	(	PUNCT
ajst-32569	12	18	e.g.	e.g.	ADV
ajst-32569	12	19	,	,	PUNCT
ajst-32569	12	20	decreased	decrease	VERB
ajst-32569	12	21	attention	attention	NOUN
ajst-32569	12	22	,	,	PUNCT
ajst-32569	12	23	executive	executive	ADJ
ajst-32569	12	24	function	function	NOUN
ajst-32569	12	25	)	)	PUNCT
ajst-32569	12	26	,	,	PUNCT
ajst-32569	12	27	and	and	CCONJ
ajst-32569	12	28	a	a	DET
ajst-32569	12	29	range	range	NOUN
ajst-32569	12	30	of	of	ADP
ajst-32569	12	31	physical	physical	ADJ
ajst-32569	12	32	symptoms	symptom	NOUN
ajst-32569	12	33	(	(	PUNCT
ajst-32569	12	34	e.g.	e.g.	ADV
ajst-32569	12	35	,	,	PUNCT
ajst-32569	12	36	sleep	sleep	NOUN
ajst-32569	12	37	,	,	PUNCT
ajst-32569	12	38	appetite	appetite	ADJ
ajst-32569	12	39	changes	change	NOUN
ajst-32569	12	40	)	)	PUNCT
ajst-32569	12	41	.	.	PUNCT
ajst-32569	13	1	although	although	SCONJ
ajst-32569	13	2	various	various	ADJ
ajst-32569	13	3	antidepressant	antidepressant	ADJ
ajst-32569	13	4	drugs	drug	NOUN
ajst-32569	13	5	(	(	PUNCT
ajst-32569	13	6	such	such	ADJ
ajst-32569	13	7	as	as	ADP
ajst-32569	13	8	selective	selective	ADJ
ajst-32569	13	9	serotonin	serotonin	NOUN
ajst-32569	13	10	reuptake	reuptake	NOUN
ajst-32569	13	11	inhibitors	inhibitor	NOUN
ajst-32569	13	12	,	,	PUNCT
ajst-32569	13	13	ssris	ssris	NOUN
ajst-32569	13	14	)	)	PUNCT
ajst-32569	13	15	and	and	CCONJ
ajst-32569	13	16	psychological	psychological	ADJ
ajst-32569	13	17	therapies	therapy	NOUN
ajst-32569	13	18	are	be	AUX
ajst-32569	13	19	widely	widely	ADV
ajst-32569	13	20	used	use	VERB
ajst-32569	13	21	in	in	ADP
ajst-32569	13	22	clinical	clinical	ADJ
ajst-32569	13	23	practice	practice	NOUN
ajst-32569	13	24	,	,	PUNCT
ajst-32569	13	25	about	about	ADV
ajst-32569	13	26	one	one	NUM
ajst-32569	13	27	-	-	PUNCT
ajst-32569	13	28	third	third	NOUN
ajst-32569	13	29	of	of	ADP
ajst-32569	13	30	patients	patient	NOUN
ajst-32569	13	31	have	have	VERB
ajst-32569	13	32	treatment	treatment	NOUN
ajst-32569	13	33	-	-	PUNCT
ajst-32569	13	34	resistant	resistant	ADJ
ajst-32569	13	35	depression	depression	NOUN
ajst-32569	13	36	(	(	PUNCT
ajst-32569	13	37	trd	trd	X
ajst-32569	13	38	)	)	PUNCT
ajst-32569	13	39	and	and	CCONJ
ajst-32569	13	40	respond	respond	VERB
ajst-32569	13	41	poorly	poorly	ADV
ajst-32569	13	42	to	to	ADP
ajst-32569	13	43	existing	exist	VERB
ajst-32569	13	44	treatments	treatment	NOUN
ajst-32569	13	45	(	(	PUNCT
ajst-32569	13	46	rush	rush	NOUN
ajst-32569	13	47	et	et	PROPN
ajst-32569	13	48	al	al	PROPN
ajst-32569	13	49	.	.	PROPN
ajst-32569	13	50	,	,	PUNCT
ajst-32569	13	51	2006	2006	NUM
ajst-32569	13	52	)	)	PUNCT
ajst-32569	13	53	.	.	PUNCT
ajst-32569	14	1	this	this	DET
ajst-32569	14	2	severe	severe	ADJ
ajst-32569	14	3	treatment	treatment	NOUN
ajst-32569	14	4	situation	situation	NOUN
ajst-32569	14	5	reveals	reveal	VERB
ajst-32569	14	6	the	the	DET
ajst-32569	14	7	complexity	complexity	NOUN
ajst-32569	14	8	of	of	ADP
ajst-32569	14	9	its	its	PRON
ajst-32569	14	10	pathophysiological	pathophysiological	ADJ
ajst-32569	14	11	mechanisms	mechanism	NOUN
ajst-32569	14	12	,	,	PUNCT
ajst-32569	14	13	far	far	ADV
ajst-32569	14	14	beyond	beyond	ADP
ajst-32569	14	15	what	what	PRON
ajst-32569	14	16	traditional	traditional	ADJ
ajst-32569	14	17	theories	theory	NOUN
ajst-32569	14	18	can	can	AUX
ajst-32569	14	19	fully	fully	ADV
ajst-32569	14	20	explain	explain	VERB
ajst-32569	14	21	,	,	PUNCT
ajst-32569	14	22	thus	thus	ADV
ajst-32569	14	23	motivating	motivate	VERB
ajst-32569	14	24	researchers	researcher	NOUN
ajst-32569	14	25	to	to	PART
ajst-32569	14	26	continuously	continuously	ADV
ajst-32569	14	27	explore	explore	VERB
ajst-32569	14	28	new	new	ADJ
ajst-32569	14	29	mechanistic	mechanistic	ADJ
ajst-32569	14	30	dimensions	dimension	NOUN
ajst-32569	14	31	.	.	PUNCT
ajst-32569	15	1	the	the	DET
ajst-32569	15	2	monoaminergic	monoaminergic	ADJ
ajst-32569	15	3	neurotransmitter	neurotransmitter	NOUN
ajst-32569	15	4	(	(	PUNCT
ajst-32569	15	5	5	5	NUM
ajst-32569	15	6	-	-	SYM
ajst-32569	15	7	ht	ht	PROPN
ajst-32569	15	8	,	,	PUNCT
ajst-32569	15	9	ne	ne	PROPN
ajst-32569	15	10	,	,	PUNCT
ajst-32569	15	11	da	da	ADJ
ajst-32569	15	12	)	)	PUNCT
ajst-32569	15	13	depletion	depletion	NOUN
ajst-32569	15	14	hypothesis	hypothesis	NOUN
ajst-32569	15	15	proposed	propose	VERB
ajst-32569	15	16	in	in	ADP
ajst-32569	15	17	the	the	DET
ajst-32569	15	18	1960s	1960	NOUN
ajst-32569	15	19	provided	provide	VERB
ajst-32569	15	20	the	the	DET
ajst-32569	15	21	theoretical	theoretical	ADJ
ajst-32569	15	22	basis	basis	NOUN
ajst-32569	15	23	for	for	ADP
ajst-32569	15	24	the	the	DET
ajst-32569	15	25	development	development	NOUN
ajst-32569	15	26	of	of	ADP
ajst-32569	15	27	first	first	ADJ
ajst-32569	15	28	-	-	PUNCT
ajst-32569	15	29	generation	generation	NOUN
ajst-32569	15	30	antidepressants	antidepressant	NOUN
ajst-32569	15	31	and	and	CCONJ
ajst-32569	15	32	remains	remain	VERB
ajst-32569	15	33	the	the	DET
ajst-32569	15	34	cornerstone	cornerstone	NOUN
ajst-32569	15	35	of	of	ADP
ajst-32569	15	36	clinical	clinical	ADJ
ajst-32569	15	37	medication	medication	NOUN
ajst-32569	15	38	.	.	PUNCT
ajst-32569	16	1	however	however	ADV
ajst-32569	16	2	,	,	PUNCT
ajst-32569	16	3	this	this	DET
ajst-32569	16	4	hypothesis	hypothesis	NOUN
ajst-32569	16	5	has	have	VERB
ajst-32569	16	6	significant	significant	ADJ
ajst-32569	16	7	limitations	limitation	NOUN
ajst-32569	16	8	:	:	PUNCT
ajst-32569	16	9	firstly	firstly	ADV
ajst-32569	16	10	,	,	PUNCT
ajst-32569	16	11	although	although	SCONJ
ajst-32569	16	12	ssris	ssris	PROPN
ajst-32569	16	13	rapidly	rapidly	ADV
ajst-32569	16	14	increase	increase	VERB
ajst-32569	16	15	synaptic	synaptic	ADJ
ajst-32569	16	16	monoamine	monoamine	NOUN
ajst-32569	16	17	levels	level	NOUN
ajst-32569	16	18	,	,	PUNCT
ajst-32569	16	19	their	their	PRON
ajst-32569	16	20	clinical	clinical	ADJ
ajst-32569	16	21	efficacy	efficacy	NOUN
ajst-32569	16	22	usually	usually	ADV
ajst-32569	16	23	takes	take	VERB
ajst-32569	16	24	2	2	NUM
ajst-32569	16	25	-	-	SYM
ajst-32569	16	26	4	4	NUM
ajst-32569	16	27	weeks	week	NOUN
ajst-32569	16	28	to	to	PART
ajst-32569	16	29	manifest	manifest	VERB
ajst-32569	16	30	,	,	PUNCT
ajst-32569	16	31	suggesting	suggest	VERB
ajst-32569	16	32	that	that	SCONJ
ajst-32569	16	33	their	their	PRON
ajst-32569	16	34	ultimate	ultimate	ADJ
ajst-32569	16	35	effect	effect	NOUN
ajst-32569	16	36	depends	depend	VERB
ajst-32569	16	37	on	on	ADP
ajst-32569	16	38	more	more	ADV
ajst-32569	16	39	complex	complex	ADJ
ajst-32569	16	40	downstream	downstream	ADJ
ajst-32569	16	41	adaptive	adaptive	ADJ
ajst-32569	16	42	changes	change	NOUN
ajst-32569	16	43	[	[	X
ajst-32569	16	44	2	2	NUM
ajst-32569	16	45	]	]	PUNCT
ajst-32569	16	46	.	.	PUNCT
ajst-32569	17	1	secondly	secondly	ADV
ajst-32569	17	2	,	,	PUNCT
ajst-32569	17	3	a	a	DET
ajst-32569	17	4	considerable	considerable	ADJ
ajst-32569	17	5	proportion	proportion	NOUN
ajst-32569	17	6	of	of	ADP
ajst-32569	17	7	patients	patient	NOUN
ajst-32569	17	8	do	do	AUX
ajst-32569	17	9	not	not	PART
ajst-32569	17	10	respond	respond	VERB
ajst-32569	17	11	to	to	ADP
ajst-32569	17	12	treatments	treatment	NOUN
ajst-32569	17	13	that	that	PRON
ajst-32569	17	14	enhance	enhance	VERB
ajst-32569	17	15	monoaminergic	monoaminergic	ADJ
ajst-32569	17	16	transmission	transmission	NOUN
ajst-32569	17	17	.	.	PUNCT
ajst-32569	18	1	these	these	DET
ajst-32569	18	2	clinical	clinical	ADJ
ajst-32569	18	3	phenomena	phenomenon	NOUN
ajst-32569	18	4	strongly	strongly	ADV
ajst-32569	18	5	suggest	suggest	VERB
ajst-32569	18	6	that	that	SCONJ
ajst-32569	18	7	the	the	DET
ajst-32569	18	8	etiology	etiology	NOUN
ajst-32569	18	9	of	of	ADP
ajst-32569	18	10	depression	depression	NOUN
ajst-32569	18	11	may	may	AUX
ajst-32569	18	12	stem	stem	VERB
ajst-32569	18	13	from	from	ADP
ajst-32569	18	14	broader	broad	ADJ
ajst-32569	18	15	neural	neural	ADJ
ajst-32569	18	16	circuit	circuit	NOUN
ajst-32569	18	17	dysfunction	dysfunction	NOUN
ajst-32569	18	18	and	and	CCONJ
ajst-32569	18	19	system	system	NOUN
ajst-32569	18	20	-	-	PUNCT
ajst-32569	18	21	level	level	NOUN
ajst-32569	18	22	physiological	physiological	ADJ
ajst-32569	18	23	dysregulation	dysregulation	NOUN
ajst-32569	18	24	.	.	PUNCT
ajst-32569	19	1	benefiting	benefit	VERB
ajst-32569	19	2	from	from	ADP
ajst-32569	19	3	the	the	DET
ajst-32569	19	4	rapid	rapid	ADJ
ajst-32569	19	5	development	development	NOUN
ajst-32569	19	6	of	of	ADP
ajst-32569	19	7	neuroimaging	neuroimaging	NOUN
ajst-32569	19	8	(	(	PUNCT
ajst-32569	19	9	e.g.	e.g.	ADV
ajst-32569	19	10	,	,	PUNCT
ajst-32569	19	11	fmri	fmri	ADJ
ajst-32569	19	12	,	,	PUNCT
ajst-32569	19	13	pet	pet	NOUN
ajst-32569	19	14	)	)	PUNCT
ajst-32569	19	15	and	and	CCONJ
ajst-32569	19	16	molecular	molecular	ADJ
ajst-32569	19	17	biology	biology	NOUN
ajst-32569	19	18	techniques	technique	NOUN
ajst-32569	19	19	,	,	PUNCT
ajst-32569	19	20	the	the	DET
ajst-32569	19	21	research	research	NOUN
ajst-32569	19	22	paradigm	paradigm	NOUN
ajst-32569	19	23	has	have	AUX
ajst-32569	19	24	successfully	successfully	ADV
ajst-32569	19	25	shifted	shift	VERB
ajst-32569	19	26	from	from	ADP
ajst-32569	19	27	a	a	DET
ajst-32569	19	28	single	single	ADJ
ajst-32569	19	29	neurochemical	neurochemical	ADJ
ajst-32569	19	30	neurotransmitter	neurotransmitter	NOUN
ajst-32569	19	31	imbalance	imbalance	NOUN
ajst-32569	19	32	to	to	ADP
ajst-32569	19	33	an	an	DET
ajst-32569	19	34	integrated	integrated	ADJ
ajst-32569	19	35	understanding	understanding	NOUN
ajst-32569	19	36	of	of	ADP
ajst-32569	19	37	multiple	multiple	ADJ
ajst-32569	19	38	interrelated	interrelated	ADJ
ajst-32569	19	39	levels	level	NOUN
ajst-32569	19	40	:	:	PUNCT
ajst-32569	19	41	neural	neural	ADJ
ajst-32569	19	42	circuits	circuit	NOUN
ajst-32569	19	43	,	,	PUNCT
ajst-32569	19	44	brain	brain	NOUN
ajst-32569	19	45	structure	structure	NOUN
ajst-32569	19	46	,	,	PUNCT
ajst-32569	19	47	and	and	CCONJ
ajst-32569	19	48	neuroimmunity	neuroimmunity	NOUN
ajst-32569	19	49	.	.	PUNCT
ajst-32569	20	1	among	among	ADP
ajst-32569	20	2	them	they	PRON
ajst-32569	20	3	,	,	PUNCT
ajst-32569	20	4	the	the	DET
ajst-32569	20	5	prefrontal	prefrontal	ADJ
ajst-32569	20	6	-	-	PUNCT
ajst-32569	20	7	limbic	limbic	ADJ
ajst-32569	20	8	system	system	NOUN
ajst-32569	20	9	circuit	circuit	NOUN
ajst-32569	20	10	(	(	PUNCT
ajst-32569	20	11	particularly	particularly	ADV
ajst-32569	20	12	involving	involve	VERB
ajst-32569	20	13	the	the	DET
ajst-32569	20	14	prefrontal	prefrontal	ADJ
ajst-32569	20	15	cortex	cortex	NOUN
ajst-32569	20	16	,	,	PUNCT
ajst-32569	20	17	anterior	anterior	ADJ
ajst-32569	20	18	cingulate	cingulate	NOUN
ajst-32569	20	19	cortex	cortex	NOUN
ajst-32569	20	20	,	,	PUNCT
ajst-32569	20	21	amygdala	amygdala	NOUN
ajst-32569	20	22	,	,	PUNCT
ajst-32569	20	23	and	and	CCONJ
ajst-32569	20	24	hippocampus	hippocampus	NOUN
ajst-32569	20	25	)	)	PUNCT
ajst-32569	20	26	is	be	AUX
ajst-32569	20	27	widely	widely	ADV
ajst-32569	20	28	accepted	accept	VERB
ajst-32569	20	29	as	as	ADP
ajst-32569	20	30	the	the	DET
ajst-32569	20	31	core	core	NOUN
ajst-32569	20	32	hub	hub	NOUN
ajst-32569	20	33	for	for	ADP
ajst-32569	20	34	regulating	regulate	VERB
ajst-32569	20	35	emotion	emotion	NOUN
ajst-32569	20	36	,	,	PUNCT
ajst-32569	20	37	motivation	motivation	NOUN
ajst-32569	20	38	,	,	PUNCT
ajst-32569	20	39	and	and	CCONJ
ajst-32569	20	40	cognitive	cognitive	ADJ
ajst-32569	20	41	function	function	NOUN
ajst-32569	20	42	,	,	PUNCT
ajst-32569	20	43	and	and	CCONJ
ajst-32569	20	44	its	its	PRON
ajst-32569	20	45	dysfunction	dysfunction	NOUN
ajst-32569	20	46	is	be	AUX
ajst-32569	20	47	widely	widely	ADV
ajst-32569	20	48	confirmed	confirm	VERB
ajst-32569	20	49	to	to	PART
ajst-32569	20	50	be	be	AUX
ajst-32569	20	51	closely	closely	ADV
ajst-32569	20	52	related	relate	VERB
ajst-32569	20	53	to	to	ADP
ajst-32569	20	54	the	the	DET
ajst-32569	20	55	core	core	NOUN
ajst-32569	20	56	symptom	symptom	NOUN
ajst-32569	20	57	spectrum	spectrum	VERB
ajst-32569	20	58	164	164	NUM
ajst-32569	20	59	of	of	ADP
ajst-32569	20	60	depression	depression	NOUN
ajst-32569	20	61	[	[	X
ajst-32569	20	62	3	3	NUM
ajst-32569	20	63	-	-	SYM
ajst-32569	20	64	4	4	NUM
ajst-32569	20	65	]	]	PUNCT
ajst-32569	20	66	.	.	PUNCT
ajst-32569	21	1	simultaneously	simultaneously	ADV
ajst-32569	21	2	,	,	PUNCT
ajst-32569	21	3	the	the	DET
ajst-32569	21	4	neuroinflammation	neuroinflammation	NOUN
ajst-32569	21	5	hypothesis	hypothesis	NOUN
ajst-32569	21	6	has	have	AUX
ajst-32569	21	7	rapidly	rapidly	ADV
ajst-32569	21	8	emerged	emerge	VERB
ajst-32569	21	9	as	as	ADP
ajst-32569	21	10	another	another	DET
ajst-32569	21	11	major	major	ADJ
ajst-32569	21	12	pillar	pillar	NOUN
ajst-32569	21	13	of	of	ADP
ajst-32569	21	14	new	new	ADJ
ajst-32569	21	15	theory	theory	NOUN
ajst-32569	21	16	,	,	PUNCT
ajst-32569	21	17	with	with	ADP
ajst-32569	21	18	substantial	substantial	ADJ
ajst-32569	21	19	evidence	evidence	NOUN
ajst-32569	21	20	indicating	indicate	VERB
ajst-32569	21	21	that	that	SCONJ
ajst-32569	21	22	the	the	DET
ajst-32569	21	23	abnormal	abnormal	ADJ
ajst-32569	21	24	activation	activation	NOUN
ajst-32569	21	25	of	of	ADP
ajst-32569	21	26	the	the	DET
ajst-32569	21	27	innate	innate	ADJ
ajst-32569	21	28	immune	immune	ADJ
ajst-32569	21	29	system	system	NOUN
ajst-32569	21	30	is	be	AUX
ajst-32569	21	31	a	a	DET
ajst-32569	21	32	key	key	ADJ
ajst-32569	21	33	factor	factor	NOUN
ajst-32569	21	34	driving	drive	VERB
ajst-32569	21	35	the	the	DET
ajst-32569	21	36	pathological	pathological	ADJ
ajst-32569	21	37	process	process	NOUN
ajst-32569	21	38	of	of	ADP
ajst-32569	21	39	depression	depression	NOUN
ajst-32569	21	40	,	,	PUNCT
ajst-32569	21	41	providing	provide	VERB
ajst-32569	21	42	a	a	DET
ajst-32569	21	43	new	new	ADJ
ajst-32569	21	44	perspective	perspective	NOUN
ajst-32569	21	45	for	for	ADP
ajst-32569	21	46	understanding	understand	VERB
ajst-32569	21	47	the	the	DET
ajst-32569	21	48	heterogeneity	heterogeneity	NOUN
ajst-32569	21	49	and	and	CCONJ
ajst-32569	21	50	comorbidity	comorbidity	NOUN
ajst-32569	21	51	(	(	PUNCT
ajst-32569	21	52	e.g.	e.g.	ADV
ajst-32569	21	53	,	,	PUNCT
ajst-32569	21	54	with	with	ADP
ajst-32569	21	55	cardiovascular	cardiovascular	ADJ
ajst-32569	21	56	disease	disease	NOUN
ajst-32569	21	57	,	,	PUNCT
ajst-32569	21	58	diabetes	diabetes	NOUN
ajst-32569	21	59	)	)	PUNCT
ajst-32569	21	60	of	of	ADP
ajst-32569	21	61	depression	depression	NOUN
ajst-32569	21	62	[	[	X
ajst-32569	21	63	5	5	NUM
ajst-32569	21	64	]	]	PUNCT
ajst-32569	21	65	.	.	PUNCT
ajst-32569	22	1	based	base	VERB
ajst-32569	22	2	on	on	ADP
ajst-32569	22	3	this	this	DET
ajst-32569	22	4	shift	shift	NOUN
ajst-32569	22	5	in	in	ADP
ajst-32569	22	6	research	research	NOUN
ajst-32569	22	7	paradigms	paradigm	NOUN
ajst-32569	22	8	,	,	PUNCT
ajst-32569	22	9	this	this	DET
ajst-32569	22	10	article	article	NOUN
ajst-32569	22	11	aims	aim	VERB
ajst-32569	22	12	to	to	PART
ajst-32569	22	13	systematically	systematically	ADV
ajst-32569	22	14	organizethe	organizethe	VERB
ajst-32569	22	15	current	current	ADJ
ajst-32569	22	16	mainstream	mainstream	ADJ
ajst-32569	22	17	international	international	ADJ
ajst-32569	22	18	research	research	NOUN
ajst-32569	22	19	directions	direction	NOUN
ajst-32569	22	20	on	on	ADP
ajst-32569	22	21	the	the	DET
ajst-32569	22	22	neurophysiological	neurophysiological	ADJ
ajst-32569	22	23	mechanisms	mechanism	NOUN
ajst-32569	22	24	of	of	ADP
ajst-32569	22	25	depression	depression	NOUN
ajst-32569	22	26	.	.	PUNCT
ajst-32569	23	1	we	we	PRON
ajst-32569	23	2	will	will	AUX
ajst-32569	23	3	not	not	PART
ajst-32569	23	4	reiterate	reiterate	VERB
ajst-32569	23	5	the	the	DET
ajst-32569	23	6	classic	classic	ADJ
ajst-32569	23	7	monoamine	monoamine	ADJ
ajst-32569	23	8	hypothesis	hypothesis	NOUN
ajst-32569	23	9	but	but	CCONJ
ajst-32569	23	10	will	will	AUX
ajst-32569	23	11	focus	focus	VERB
ajst-32569	23	12	on	on	ADP
ajst-32569	23	13	two	two	NUM
ajst-32569	23	14	frontier	frontier	NOUN
ajst-32569	23	15	areas	area	NOUN
ajst-32569	23	16	with	with	ADP
ajst-32569	23	17	the	the	DET
ajst-32569	23	18	most	most	ADV
ajst-32569	23	19	substantial	substantial	ADJ
ajst-32569	23	20	evidence	evidence	NOUN
ajst-32569	23	21	and	and	CCONJ
ajst-32569	23	22	profound	profound	ADJ
ajst-32569	23	23	interactions	interaction	NOUN
ajst-32569	23	24	:	:	PUNCT
ajst-32569	23	25	(	(	PUNCT
ajst-32569	23	26	1	1	X
ajst-32569	23	27	)	)	PUNCT
ajst-32569	23	28	brain	brain	NOUN
ajst-32569	23	29	structural	structural	ADJ
ajst-32569	23	30	abnormalities	abnormality	NOUN
ajst-32569	23	31	and	and	CCONJ
ajst-32569	23	32	neural	neural	ADJ
ajst-32569	23	33	circuit	circuit	NOUN
ajst-32569	23	34	dysfunction	dysfunction	NOUN
ajst-32569	23	35	:	:	PUNCT
ajst-32569	23	36	reviewing	review	VERB
ajst-32569	23	37	morphological	morphological	ADJ
ajst-32569	23	38	changes	change	NOUN
ajst-32569	23	39	in	in	ADP
ajst-32569	23	40	key	key	ADJ
ajst-32569	23	41	brain	brain	NOUN
ajst-32569	23	42	regions	region	NOUN
ajst-32569	23	43	(	(	PUNCT
ajst-32569	23	44	e.g.	e.g.	ADV
ajst-32569	23	45	,	,	PUNCT
ajst-32569	23	46	pfc	pfc	NOUN
ajst-32569	23	47	,	,	PUNCT
ajst-32569	23	48	hippocampus	hippocampus	NOUN
ajst-32569	23	49	,	,	PUNCT
ajst-32569	23	50	amygdala	amygdala	NOUN
ajst-32569	23	51	)	)	PUNCT
ajst-32569	23	52	and	and	CCONJ
ajst-32569	23	53	the	the	DET
ajst-32569	23	54	underlying	underlying	ADJ
ajst-32569	23	55	neurotrophic	neurotrophic	ADJ
ajst-32569	23	56	factor	factor	NOUN
ajst-32569	23	57	regulatory	regulatory	ADJ
ajst-32569	23	58	mechanisms	mechanism	NOUN
ajst-32569	23	59	(	(	PUNCT
ajst-32569	23	60	e.g.	e.g.	ADV
ajst-32569	23	61	,	,	PUNCT
ajst-32569	23	62	the	the	DET
ajst-32569	23	63	bdnf	bdnf	ADJ
ajst-32569	23	64	hypothesis	hypothesis	NOUN
ajst-32569	23	65	)	)	PUNCT
ajst-32569	23	66	;	;	PUNCT
ajst-32569	23	67	(	(	PUNCT
ajst-32569	23	68	2	2	X
ajst-32569	23	69	)	)	PUNCT
ajst-32569	23	70	neuroinflammation	neuroinflammation	NOUN
ajst-32569	23	71	mechanisms	mechanism	NOUN
ajst-32569	23	72	:	:	PUNCT
ajst-32569	23	73	exploring	explore	VERB
ajst-32569	23	74	how	how	SCONJ
ajst-32569	23	75	peripheral	peripheral	ADJ
ajst-32569	23	76	and	and	CCONJ
ajst-32569	23	77	central	central	ADJ
ajst-32569	23	78	immune	immune	ADJ
ajst-32569	23	79	activation	activation	NOUN
ajst-32569	23	80	ultimately	ultimately	ADV
ajst-32569	23	81	leads	lead	VERB
ajst-32569	23	82	to	to	ADP
ajst-32569	23	83	depressive	depressive	ADJ
ajst-32569	23	84	behavioral	behavioral	ADJ
ajst-32569	23	85	phenotypes	phenotype	NOUN
ajst-32569	23	86	by	by	ADP
ajst-32569	23	87	affecting	affect	VERB
ajst-32569	23	88	neurotransmitter	neurotransmitter	NOUN
ajst-32569	23	89	metabolism	metabolism	NOUN
ajst-32569	23	90	,	,	PUNCT
ajst-32569	23	91	the	the	DET
ajst-32569	23	92	neuroendocrine	neuroendocrine	NOUN
ajst-32569	23	93	system	system	NOUN
ajst-32569	23	94	,	,	PUNCT
ajst-32569	23	95	and	and	CCONJ
ajst-32569	23	96	neuroplasticity	neuroplasticity	NOUN
ajst-32569	23	97	.	.	PUNCT
ajst-32569	24	1	through	through	ADP
ajst-32569	24	2	the	the	DET
ajst-32569	24	3	integration	integration	NOUN
ajst-32569	24	4	and	and	CCONJ
ajst-32569	24	5	analysis	analysis	NOUN
ajst-32569	24	6	of	of	ADP
ajst-32569	24	7	existing	exist	VERB
ajst-32569	24	8	high	high	ADJ
ajst-32569	24	9	-	-	PUNCT
ajst-32569	24	10	level	level	NOUN
ajst-32569	24	11	literature	literature	NOUN
ajst-32569	24	12	(	(	PUNCT
ajst-32569	24	13	including	include	VERB
ajst-32569	24	14	systematic	systematic	ADJ
ajst-32569	24	15	reviews	review	NOUN
ajst-32569	24	16	and	and	CCONJ
ajst-32569	24	17	meta	meta	NOUN
ajst-32569	24	18	-	-	PUNCT
ajst-32569	24	19	analyses	analysis	NOUN
ajst-32569	24	20	)	)	PUNCT
ajst-32569	24	21	,	,	PUNCT
ajst-32569	24	22	we	we	PRON
ajst-32569	24	23	hope	hope	VERB
ajst-32569	24	24	to	to	PART
ajst-32569	24	25	construct	construct	VERB
ajst-32569	24	26	a	a	DET
ajst-32569	24	27	more	more	ADV
ajst-32569	24	28	systematic	systematic	ADJ
ajst-32569	24	29	and	and	CCONJ
ajst-32569	24	30	comprehensive	comprehensive	ADJ
ajst-32569	24	31	neurophysiological	neurophysiological	ADJ
ajst-32569	24	32	model	model	NOUN
ajst-32569	24	33	of	of	ADP
ajst-32569	24	34	depression	depression	NOUN
ajst-32569	24	35	and	and	CCONJ
ajst-32569	24	36	discuss	discuss	VERB
ajst-32569	24	37	its	its	PRON
ajst-32569	24	38	potential	potential	ADJ
ajst-32569	24	39	translational	translational	ADJ
ajst-32569	24	40	value	value	NOUN
ajst-32569	24	41	for	for	ADP
ajst-32569	24	42	developing	develop	VERB
ajst-32569	24	43	new	new	ADJ
ajst-32569	24	44	diagnostic	diagnostic	ADJ
ajst-32569	24	45	tools	tool	NOUN
ajst-32569	24	46	and	and	CCONJ
ajst-32569	24	47	targeted	target	VERB
ajst-32569	24	48	treatment	treatment	NOUN
ajst-32569	24	49	strategies	strategy	NOUN
ajst-32569	24	50	.	.	PUNCT
ajst-32569	25	1	2	2	X
ajst-32569	25	2	.	.	X
ajst-32569	25	3	neural	neural	ADJ
ajst-32569	25	4	structural	structural	ADJ
ajst-32569	25	5	abnormalities	abnormality	NOUN
ajst-32569	25	6	and	and	CCONJ
ajst-32569	25	7	depression	depression	NOUN
ajst-32569	25	8	for	for	ADP
ajst-32569	25	9	a	a	DET
ajst-32569	25	10	long	long	ADJ
ajst-32569	25	11	time	time	NOUN
ajst-32569	25	12	,	,	PUNCT
ajst-32569	25	13	depression	depression	NOUN
ajst-32569	25	14	was	be	AUX
ajst-32569	25	15	considered	consider	VERB
ajst-32569	25	16	a	a	DET
ajst-32569	25	17	functional	functional	ADJ
ajst-32569	25	18	mental	mental	ADJ
ajst-32569	25	19	disorder	disorder	NOUN
ajst-32569	25	20	lacking	lack	VERB
ajst-32569	25	21	clear	clear	ADJ
ajst-32569	25	22	biological	biological	ADJ
ajst-32569	25	23	markers	marker	NOUN
ajst-32569	25	24	.	.	PUNCT
ajst-32569	26	1	however	however	ADV
ajst-32569	26	2	,	,	PUNCT
ajst-32569	26	3	with	with	ADP
ajst-32569	26	4	the	the	DET
ajst-32569	26	5	popularization	popularization	NOUN
ajst-32569	26	6	of	of	ADP
ajst-32569	26	7	high	high	ADJ
ajst-32569	26	8	-	-	PUNCT
ajst-32569	26	9	resolution	resolution	NOUN
ajst-32569	26	10	magnetic	magnetic	ADJ
ajst-32569	26	11	resonance	resonance	NOUN
ajst-32569	26	12	imaging	imaging	NOUN
ajst-32569	26	13	(	(	PUNCT
ajst-32569	26	14	mri	mri	NOUN
ajst-32569	26	15	)	)	PUNCT
ajst-32569	26	16	technology	technology	NOUN
ajst-32569	26	17	and	and	CCONJ
ajst-32569	26	18	the	the	DET
ajst-32569	26	19	application	application	NOUN
ajst-32569	26	20	of	of	ADP
ajst-32569	26	21	large	large	ADJ
ajst-32569	26	22	-	-	PUNCT
ajst-32569	26	23	scale	scale	NOUN
ajst-32569	26	24	data	datum	NOUN
ajst-32569	26	25	analysis	analysis	NOUN
ajst-32569	26	26	methods	method	NOUN
ajst-32569	26	27	,	,	PUNCT
ajst-32569	26	28	it	it	PRON
ajst-32569	26	29	has	have	AUX
ajst-32569	26	30	become	become	VERB
ajst-32569	26	31	an	an	DET
ajst-32569	26	32	indisputable	indisputable	ADJ
ajst-32569	26	33	scientific	scientific	ADJ
ajst-32569	26	34	fact	fact	NOUN
ajst-32569	26	35	that	that	SCONJ
ajst-32569	26	36	patients	patient	NOUN
ajst-32569	26	37	with	with	ADP
ajst-32569	26	38	depression	depression	NOUN
ajst-32569	26	39	exhibit	exhibit	VERB
ajst-32569	26	40	extensive	extensive	ADJ
ajst-32569	26	41	and	and	CCONJ
ajst-32569	26	42	reproducible	reproducible	VERB
ajst-32569	26	43	brain	brain	NOUN
ajst-32569	26	44	structural	structural	ADJ
ajst-32569	26	45	abnormalities	abnormality	NOUN
ajst-32569	26	46	.	.	PUNCT
ajst-32569	27	1	these	these	DET
ajst-32569	27	2	abnormalities	abnormality	NOUN
ajst-32569	27	3	are	be	AUX
ajst-32569	27	4	not	not	PART
ajst-32569	27	5	confined	confine	VERB
ajst-32569	27	6	to	to	ADP
ajst-32569	27	7	a	a	DET
ajst-32569	27	8	specific	specific	ADJ
ajst-32569	27	9	brain	brain	NOUN
ajst-32569	27	10	region	region	NOUN
ajst-32569	27	11	but	but	CCONJ
ajst-32569	27	12	affect	affect	VERB
ajst-32569	27	13	large	large	ADJ
ajst-32569	27	14	-	-	PUNCT
ajst-32569	27	15	scale	scale	NOUN
ajst-32569	27	16	distributed	distribute	VERB
ajst-32569	27	17	networks	network	NOUN
ajst-32569	27	18	involved	involve	VERB
ajst-32569	27	19	in	in	ADP
ajst-32569	27	20	emotional	emotional	ADJ
ajst-32569	27	21	processing	processing	NOUN
ajst-32569	27	22	,	,	PUNCT
ajst-32569	27	23	cognitive	cognitive	ADJ
ajst-32569	27	24	control	control	NOUN
ajst-32569	27	25	,	,	PUNCT
ajst-32569	27	26	and	and	CCONJ
ajst-32569	27	27	motivational	motivational	ADJ
ajst-32569	27	28	reward	reward	NOUN
ajst-32569	27	29	,	,	PUNCT
ajst-32569	27	30	among	among	ADP
ajst-32569	27	31	which	which	PRON
ajst-32569	27	32	the	the	DET
ajst-32569	27	33	prefrontal	prefrontal	ADJ
ajst-32569	27	34	-	-	PUNCT
ajst-32569	27	35	limbic	limbic	ADJ
ajst-32569	27	36	circuitry	circuitry	NOUN
ajst-32569	27	37	is	be	AUX
ajst-32569	27	38	the	the	DET
ajst-32569	27	39	most	most	ADV
ajst-32569	27	40	core	core	NOUN
ajst-32569	28	1	[	[	X
ajst-32569	28	2	6	6	NUM
ajst-32569	28	3	-	-	SYM
ajst-32569	28	4	7	7	NUM
ajst-32569	28	5	]	]	PUNCT
ajst-32569	28	6	.	.	PUNCT
ajst-32569	29	1	early	early	ADJ
ajst-32569	29	2	neuroimaging	neuroimage	VERB
ajst-32569	29	3	studies	study	NOUN
ajst-32569	29	4	,	,	PUNCT
ajst-32569	29	5	primarily	primarily	ADV
ajst-32569	29	6	based	base	VERB
ajst-32569	29	7	on	on	ADP
ajst-32569	29	8	voxel	voxel	PROPN
ajst-32569	29	9	-	-	PUNCT
ajst-32569	29	10	based	base	VERB
ajst-32569	29	11	morphometry	morphometry	NOUN
ajst-32569	29	12	(	(	PUNCT
ajst-32569	29	13	vbm	vbm	PROPN
ajst-32569	29	14	)	)	PUNCT
ajst-32569	29	15	comparing	compare	VERB
ajst-32569	29	16	brain	brain	NOUN
ajst-32569	29	17	gray	gray	ADJ
ajst-32569	29	18	matter	matter	NOUN
ajst-32569	29	19	volume	volume	NOUN
ajst-32569	29	20	between	between	ADP
ajst-32569	29	21	patients	patient	NOUN
ajst-32569	29	22	and	and	CCONJ
ajst-32569	29	23	healthy	healthy	ADJ
ajst-32569	29	24	controls	control	NOUN
ajst-32569	29	25	,	,	PUNCT
ajst-32569	29	26	found	find	VERB
ajst-32569	29	27	gray	gray	ADJ
ajst-32569	29	28	matter	matter	NOUN
ajst-32569	29	29	volume	volume	NOUN
ajst-32569	29	30	reduction	reduction	NOUN
ajst-32569	29	31	in	in	ADP
ajst-32569	29	32	multiple	multiple	ADJ
ajst-32569	29	33	brain	brain	NOUN
ajst-32569	29	34	regions	region	NOUN
ajst-32569	29	35	in	in	ADP
ajst-32569	29	36	mdd	mdd	PROPN
ajst-32569	29	37	patients	patient	NOUN
ajst-32569	29	38	.	.	PUNCT
ajst-32569	30	1	in	in	ADP
ajst-32569	30	2	recent	recent	ADJ
ajst-32569	30	3	years	year	NOUN
ajst-32569	30	4	,	,	PUNCT
ajst-32569	30	5	large	large	ADJ
ajst-32569	30	6	multi	multi	ADJ
ajst-32569	30	7	-	-	ADJ
ajst-32569	30	8	center	center	ADJ
ajst-32569	30	9	consortia	consortia	NOUN
ajst-32569	30	10	,	,	PUNCT
ajst-32569	30	11	such	such	ADJ
ajst-32569	30	12	as	as	ADP
ajst-32569	30	13	the	the	DET
ajst-32569	30	14	enigma	enigma	NOUN
ajst-32569	30	15	(	(	PUNCT
ajst-32569	30	16	enhancing	enhance	VERB
ajst-32569	30	17	neuro	neuro	PROPN
ajst-32569	30	18	imaging	imaging	NOUN
ajst-32569	30	19	genetics	genetic	NOUN
ajst-32569	30	20	through	through	ADP
ajst-32569	30	21	meta	meta	ADJ
ajst-32569	30	22	analysis	analysis	NOUN
ajst-32569	30	23	)	)	PUNCT
ajst-32569	30	24	mdd	mdd	PROPN
ajst-32569	30	25	working	working	PROPN
ajst-32569	30	26	group	group	NOUN
ajst-32569	30	27	,	,	PUNCT
ajst-32569	30	28	have	have	AUX
ajst-32569	30	29	greatly	greatly	ADV
ajst-32569	30	30	enhanced	enhance	VERB
ajst-32569	30	31	the	the	DET
ajst-32569	30	32	reliability	reliability	NOUN
ajst-32569	30	33	and	and	CCONJ
ajst-32569	30	34	generalizability	generalizability	NOUN
ajst-32569	30	35	of	of	ADP
ajst-32569	30	36	these	these	DET
ajst-32569	30	37	findings	finding	NOUN
ajst-32569	30	38	by	by	ADP
ajst-32569	30	39	conducting	conduct	VERB
ajst-32569	30	40	meta	meta	NOUN
ajst-32569	30	41	-	-	PUNCT
ajst-32569	30	42	analyses	analysis	NOUN
ajst-32569	30	43	of	of	ADP
ajst-32569	30	44	brain	brain	NOUN
ajst-32569	30	45	imaging	imaging	NOUN
ajst-32569	30	46	data	datum	NOUN
ajst-32569	30	47	from	from	ADP
ajst-32569	30	48	thousands	thousand	NOUN
ajst-32569	30	49	of	of	ADP
ajst-32569	30	50	subjects	subject	NOUN
ajst-32569	30	51	worldwide	worldwide	ADV
ajst-32569	31	1	[	[	X
ajst-32569	31	2	8	8	NUM
ajst-32569	31	3	]	]	PUNCT
ajst-32569	31	4	.	.	PUNCT
ajst-32569	32	1	these	these	DET
ajst-32569	32	2	studies	study	NOUN
ajst-32569	32	3	consistently	consistently	ADV
ajst-32569	32	4	confirm	confirm	VERB
ajst-32569	32	5	that	that	SCONJ
ajst-32569	32	6	compared	compare	VERB
ajst-32569	32	7	to	to	ADP
ajst-32569	32	8	healthy	healthy	ADJ
ajst-32569	32	9	controls	control	NOUN
ajst-32569	32	10	,	,	PUNCT
ajst-32569	32	11	mdd	mdd	PROPN
ajst-32569	32	12	patients	patient	NOUN
ajst-32569	32	13	show	show	VERB
ajst-32569	32	14	significant	significant	ADJ
ajst-32569	32	15	gray	gray	ADJ
ajst-32569	32	16	matter	matter	NOUN
ajst-32569	32	17	volume	volume	NOUN
ajst-32569	32	18	reductions	reduction	NOUN
ajst-32569	32	19	in	in	ADP
ajst-32569	32	20	the	the	DET
ajst-32569	32	21	following	follow	VERB
ajst-32569	32	22	key	key	ADJ
ajst-32569	32	23	brain	brain	NOUN
ajst-32569	32	24	regions	region	NOUN
ajst-32569	32	25	:	:	PUNCT
ajst-32569	32	26	in	in	ADP
ajst-32569	32	27	the	the	DET
ajst-32569	32	28	prefrontal	prefrontal	ADJ
ajst-32569	32	29	cortex	cortex	NOUN
ajst-32569	32	30	(	(	PUNCT
ajst-32569	32	31	pfc	pfc	NOUN
ajst-32569	32	32	)	)	PUNCT
ajst-32569	32	33	,	,	PUNCT
ajst-32569	32	34	particularly	particularly	ADV
ajst-32569	32	35	the	the	DET
ajst-32569	32	36	dorsolateral	dorsolateral	ADJ
ajst-32569	32	37	prefrontal	prefrontal	ADJ
ajst-32569	32	38	cortex	cortex	NOUN
ajst-32569	32	39	(	(	PUNCT
ajst-32569	32	40	dlpfc	dlpfc	NOUN
ajst-32569	32	41	)	)	PUNCT
ajst-32569	32	42	associated	associate	VERB
ajst-32569	32	43	with	with	ADP
ajst-32569	32	44	executive	executive	ADJ
ajst-32569	32	45	function	function	NOUN
ajst-32569	32	46	and	and	CCONJ
ajst-32569	32	47	emotion	emotion	NOUN
ajst-32569	32	48	regulation	regulation	NOUN
ajst-32569	32	49	,	,	PUNCT
ajst-32569	32	50	and	and	CCONJ
ajst-32569	32	51	the	the	DET
ajst-32569	32	52	orbitofrontal	orbitofrontal	ADJ
ajst-32569	32	53	cortex	cortex	NOUN
ajst-32569	32	54	(	(	PUNCT
ajst-32569	32	55	ofc	ofc	NOUN
ajst-32569	32	56	)	)	PUNCT
ajst-32569	32	57	and	and	CCONJ
ajst-32569	32	58	anterior	anterior	ADJ
ajst-32569	32	59	cingulate	cingulate	NOUN
ajst-32569	32	60	cortex	cortex	NOUN
ajst-32569	32	61	(	(	PUNCT
ajst-32569	32	62	acc	acc	PROPN
ajst-32569	32	63	)	)	PUNCT
ajst-32569	32	64	associated	associate	VERB
ajst-32569	32	65	with	with	ADP
ajst-32569	32	66	affective	affective	ADJ
ajst-32569	32	67	evaluation	evaluation	NOUN
ajst-32569	32	68	and	and	CCONJ
ajst-32569	32	69	decisionmaking	decisionmaking	NOUN
ajst-32569	32	70	.	.	PUNCT
ajst-32569	33	1	in	in	ADP
ajst-32569	33	2	the	the	DET
ajst-32569	33	3	hippocampus	hippocampus	NOUN
ajst-32569	33	4	,	,	PUNCT
ajst-32569	33	5	associated	associate	VERB
ajst-32569	33	6	with	with	ADP
ajst-32569	33	7	memory	memory	NOUN
ajst-32569	33	8	consolidation	consolidation	NOUN
ajst-32569	33	9	and	and	CCONJ
ajst-32569	33	10	stress	stress	NOUN
ajst-32569	33	11	regulation	regulation	NOUN
ajst-32569	33	12	.	.	PUNCT
ajst-32569	34	1	the	the	DET
ajst-32569	34	2	anterior	anterior	ADJ
ajst-32569	34	3	insula	insula	NOUN
ajst-32569	34	4	is	be	AUX
ajst-32569	34	5	associated	associate	VERB
ajst-32569	34	6	with	with	ADP
ajst-32569	34	7	interoceptive	interoceptive	ADJ
ajst-32569	34	8	awareness	awareness	NOUN
ajst-32569	34	9	and	and	CCONJ
ajst-32569	34	10	emotional	emotional	ADJ
ajst-32569	34	11	experience	experience	NOUN
ajst-32569	34	12	.	.	PUNCT
ajst-32569	35	1	the	the	DET
ajst-32569	35	2	striatum	striatum	NOUN
ajst-32569	35	3	,	,	PUNCT
ajst-32569	35	4	specifically	specifically	ADV
ajst-32569	35	5	the	the	DET
ajst-32569	35	6	nucleus	nucleus	ADJ
ajst-32569	35	7	accumbens	accumben	NOUN
ajst-32569	35	8	(	(	PUNCT
ajst-32569	35	9	nacc	nacc	ADV
ajst-32569	35	10	)	)	PUNCT
ajst-32569	35	11	,	,	PUNCT
ajst-32569	35	12	is	be	AUX
ajst-32569	35	13	associated	associate	VERB
ajst-32569	35	14	with	with	ADP
ajst-32569	35	15	reward	reward	NOUN
ajst-32569	35	16	processing	processing	NOUN
ajst-32569	35	17	and	and	CCONJ
ajst-32569	35	18	motivation	motivation	NOUN
ajst-32569	35	19	.	.	PUNCT
ajst-32569	36	1	these	these	DET
ajst-32569	36	2	structural	structural	ADJ
ajst-32569	36	3	changes	change	NOUN
ajst-32569	36	4	provide	provide	VERB
ajst-32569	36	5	an	an	DET
ajst-32569	36	6	intuitive	intuitive	ADJ
ajst-32569	36	7	neuroanatomical	neuroanatomical	ADJ
ajst-32569	36	8	explanation	explanation	NOUN
ajst-32569	36	9	for	for	ADP
ajst-32569	36	10	the	the	DET
ajst-32569	36	11	clinical	clinical	ADJ
ajst-32569	36	12	symptoms	symptom	NOUN
ajst-32569	36	13	of	of	ADP
ajst-32569	36	14	depression	depression	NOUN
ajst-32569	36	15	:	:	PUNCT
ajst-32569	36	16	atrophy	atrophy	NOUN
ajst-32569	36	17	of	of	ADP
ajst-32569	36	18	prefrontal	prefrontal	ADJ
ajst-32569	36	19	regions	region	NOUN
ajst-32569	36	20	is	be	AUX
ajst-32569	36	21	associated	associate	VERB
ajst-32569	36	22	with	with	ADP
ajst-32569	36	23	decreased	decrease	VERB
ajst-32569	36	24	cognitive	cognitive	ADJ
ajst-32569	36	25	flexibility	flexibility	NOUN
ajst-32569	36	26	and	and	CCONJ
ajst-32569	36	27	impaired	impaired	ADJ
ajst-32569	36	28	emotion	emotion	NOUN
ajst-32569	36	29	regulation	regulation	NOUN
ajst-32569	36	30	;	;	PUNCT
ajst-32569	36	31	reduced	reduce	VERB
ajst-32569	36	32	hippocampal	hippocampal	ADJ
ajst-32569	36	33	volume	volume	NOUN
ajst-32569	36	34	is	be	AUX
ajst-32569	36	35	associated	associate	VERB
ajst-32569	36	36	with	with	ADP
ajst-32569	36	37	memory	memory	NOUN
ajst-32569	36	38	problems	problem	NOUN
ajst-32569	36	39	and	and	CCONJ
ajst-32569	36	40	persistent	persistent	ADJ
ajst-32569	36	41	hpa	hpa	NOUN
ajst-32569	36	42	axis	axis	NOUN
ajst-32569	36	43	hyperactivity	hyperactivity	NOUN
ajst-32569	36	44	;	;	PUNCT
ajst-32569	36	45	and	and	CCONJ
ajst-32569	36	46	changes	change	NOUN
ajst-32569	36	47	in	in	ADP
ajst-32569	36	48	reward	reward	NOUN
ajst-32569	36	49	-	-	PUNCT
ajst-32569	36	50	related	relate	VERB
ajst-32569	36	51	regions	region	NOUN
ajst-32569	36	52	directly	directly	ADV
ajst-32569	36	53	lead	lead	VERB
ajst-32569	36	54	to	to	ADP
ajst-32569	36	55	the	the	DET
ajst-32569	36	56	core	core	ADJ
ajst-32569	36	57	symptom	symptom	NOUN
ajst-32569	36	58	of	of	ADP
ajst-32569	36	59	anhedonia	anhedonia	NOUN
ajst-32569	36	60	.	.	PUNCT
ajst-32569	37	1	recent	recent	ADJ
ajst-32569	37	2	research	research	NOUN
ajst-32569	37	3	has	have	AUX
ajst-32569	37	4	made	make	VERB
ajst-32569	37	5	significant	significant	ADJ
ajst-32569	37	6	progress	progress	NOUN
ajst-32569	37	7	in	in	ADP
ajst-32569	37	8	the	the	DET
ajst-32569	37	9	following	follow	VERB
ajst-32569	37	10	aspects	aspect	NOUN
ajst-32569	37	11	,	,	PUNCT
ajst-32569	37	12	advancing	advance	VERB
ajst-32569	37	13	the	the	DET
ajst-32569	37	14	depth	depth	NOUN
ajst-32569	37	15	and	and	CCONJ
ajst-32569	37	16	breadth	breadth	NOUN
ajst-32569	37	17	of	of	ADP
ajst-32569	37	18	the	the	DET
ajst-32569	37	19	field	field	NOUN
ajst-32569	37	20	:	:	PUNCT
ajst-32569	37	21	from	from	ADP
ajst-32569	37	22	cross	cross	ADJ
ajst-32569	37	23	-	-	ADJ
ajst-32569	37	24	sectional	sectional	ADJ
ajst-32569	37	25	to	to	ADP
ajst-32569	37	26	longitudinal	longitudinal	ADJ
ajst-32569	37	27	design	design	NOUN
ajst-32569	37	28	.	.	PUNCT
ajst-32569	38	1	early	early	ADJ
ajst-32569	38	2	studies	study	NOUN
ajst-32569	38	3	were	be	AUX
ajst-32569	38	4	mostly	mostly	ADV
ajst-32569	38	5	cross	cross	ADJ
ajst-32569	38	6	-	-	ADJ
ajst-32569	38	7	sectional	sectional	ADJ
ajst-32569	38	8	comparisons	comparison	NOUN
ajst-32569	38	9	,	,	PUNCT
ajst-32569	38	10	unable	unable	ADJ
ajst-32569	38	11	to	to	PART
ajst-32569	38	12	determine	determine	VERB
ajst-32569	38	13	whether	whether	SCONJ
ajst-32569	38	14	structural	structural	ADJ
ajst-32569	38	15	abnormalities	abnormality	NOUN
ajst-32569	38	16	were	be	AUX
ajst-32569	38	17	causes	cause	NOUN
ajst-32569	38	18	or	or	CCONJ
ajst-32569	38	19	consequences	consequence	NOUN
ajst-32569	38	20	.	.	PUNCT
ajst-32569	39	1	current	current	ADJ
ajst-32569	39	2	longitudinal	longitudinal	ADJ
ajst-32569	39	3	tracking	tracking	NOUN
ajst-32569	39	4	studies	study	NOUN
ajst-32569	39	5	show	show	VERB
ajst-32569	39	6	that	that	SCONJ
ajst-32569	39	7	volume	volume	NOUN
ajst-32569	39	8	reduction	reduction	NOUN
ajst-32569	39	9	in	in	ADP
ajst-32569	39	10	brain	brain	NOUN
ajst-32569	39	11	regions	region	NOUN
ajst-32569	39	12	like	like	ADP
ajst-32569	39	13	the	the	DET
ajst-32569	39	14	165	165	NUM
ajst-32569	39	15	hippocampus	hippocampus	NOUN
ajst-32569	39	16	may	may	AUX
ajst-32569	39	17	be	be	AUX
ajst-32569	39	18	a	a	DET
ajst-32569	39	19	state	state	NOUN
ajst-32569	39	20	marker	marker	NOUN
ajst-32569	39	21	,	,	PUNCT
ajst-32569	39	22	which	which	PRON
ajst-32569	39	23	can	can	AUX
ajst-32569	39	24	be	be	AUX
ajst-32569	39	25	partially	partially	ADV
ajst-32569	39	26	normalized	normalize	VERB
ajst-32569	39	27	with	with	ADP
ajst-32569	39	28	successful	successful	ADJ
ajst-32569	39	29	antidepressant	antidepressant	ADJ
ajst-32569	39	30	treatment	treatment	NOUN
ajst-32569	39	31	(	(	PUNCT
ajst-32569	39	32	especially	especially	ADV
ajst-32569	39	33	electroconvulsive	electroconvulsive	ADJ
ajst-32569	39	34	therapy	therapy	NOUN
ajst-32569	39	35	ect	ect	X
ajst-32569	39	36	and	and	CCONJ
ajst-32569	39	37	ketamine	ketamine	PROPN
ajst-32569	39	38	)	)	PUNCT
ajst-32569	40	1	[	[	X
ajst-32569	40	2	9	9	NUM
ajst-32569	40	3	]	]	PUNCT
ajst-32569	40	4	.	.	PUNCT
ajst-32569	41	1	this	this	PRON
ajst-32569	41	2	proves	prove	VERB
ajst-32569	41	3	that	that	SCONJ
ajst-32569	41	4	these	these	DET
ajst-32569	41	5	structural	structural	ADJ
ajst-32569	41	6	changes	change	NOUN
ajst-32569	41	7	have	have	VERB
ajst-32569	41	8	a	a	DET
ajst-32569	41	9	certain	certain	ADJ
ajst-32569	41	10	degree	degree	NOUN
ajst-32569	41	11	of	of	ADP
ajst-32569	41	12	plasticity	plasticity	NOUN
ajst-32569	41	13	,	,	PUNCT
ajst-32569	41	14	offering	offer	VERB
ajst-32569	41	15	hope	hope	NOUN
ajst-32569	41	16	for	for	ADP
ajst-32569	41	17	treatment	treatment	NOUN
ajst-32569	41	18	.	.	PUNCT
ajst-32569	42	1	focus	focus	VERB
ajst-32569	42	2	on	on	ADP
ajst-32569	42	3	heterogeneity	heterogeneity	NOUN
ajst-32569	42	4	and	and	CCONJ
ajst-32569	42	5	subtypes	subtype	NOUN
ajst-32569	42	6	.	.	PUNCT
ajst-32569	43	1	recognizing	recognize	VERB
ajst-32569	43	2	the	the	DET
ajst-32569	43	3	high	high	ADJ
ajst-32569	43	4	heterogeneity	heterogeneity	NOUN
ajst-32569	43	5	of	of	ADP
ajst-32569	43	6	depression	depression	NOUN
ajst-32569	43	7	,	,	PUNCT
ajst-32569	43	8	the	the	DET
ajst-32569	43	9	latest	late	ADJ
ajst-32569	43	10	research	research	NOUN
ajst-32569	43	11	is	be	AUX
ajst-32569	43	12	dedicated	dedicate	VERB
ajst-32569	43	13	to	to	ADP
ajst-32569	43	14	finding	find	VERB
ajst-32569	43	15	specific	specific	ADJ
ajst-32569	43	16	brain	brain	NOUN
ajst-32569	43	17	structural	structural	ADJ
ajst-32569	43	18	patterns	pattern	NOUN
ajst-32569	43	19	associated	associate	VERB
ajst-32569	43	20	with	with	ADP
ajst-32569	43	21	specific	specific	ADJ
ajst-32569	43	22	clinical	clinical	ADJ
ajst-32569	43	23	symptom	symptom	NOUN
ajst-32569	43	24	profiles	profile	NOUN
ajst-32569	43	25	(	(	PUNCT
ajst-32569	43	26	e.g.	e.g.	ADV
ajst-32569	43	27	,	,	PUNCT
ajst-32569	43	28	anxiety	anxiety	NOUN
ajst-32569	43	29	,	,	PUNCT
ajst-32569	43	30	anhedonia	anhedonia	NOUN
ajst-32569	43	31	,	,	PUNCT
ajst-32569	43	32	cognitive	cognitive	ADJ
ajst-32569	43	33	impairment	impairment	NOUN
ajst-32569	43	34	)	)	PUNCT
ajst-32569	43	35	.	.	PUNCT
ajst-32569	44	1	for	for	ADP
ajst-32569	44	2	example	example	NOUN
ajst-32569	44	3	,	,	PUNCT
ajst-32569	44	4	patients	patient	NOUN
ajst-32569	44	5	with	with	ADP
ajst-32569	44	6	anhedonia	anhedonia	NOUN
ajst-32569	44	7	as	as	ADP
ajst-32569	44	8	a	a	DET
ajst-32569	44	9	core	core	NOUN
ajst-32569	44	10	symptom	symptom	NOUN
ajst-32569	44	11	may	may	AUX
ajst-32569	44	12	exhibit	exhibit	VERB
ajst-32569	44	13	more	more	ADV
ajst-32569	44	14	pronounced	pronounced	ADJ
ajst-32569	44	15	striatal	striatal	ADJ
ajst-32569	44	16	volume	volume	NOUN
ajst-32569	44	17	reduction	reduction	NOUN
ajst-32569	44	18	[	[	X
ajst-32569	44	19	10	10	NUM
ajst-32569	44	20	]	]	PUNCT
ajst-32569	44	21	.	.	PUNCT
ajst-32569	45	1	multimodal	multimodal	ADJ
ajst-32569	45	2	fusion	fusion	NOUN
ajst-32569	45	3	and	and	CCONJ
ajst-32569	45	4	machine	machine	NOUN
ajst-32569	45	5	learning	learning	NOUN
ajst-32569	45	6	.	.	PUNCT
ajst-32569	46	1	relying	rely	VERB
ajst-32569	46	2	solely	solely	ADV
ajst-32569	46	3	on	on	ADP
ajst-32569	46	4	structural	structural	ADJ
ajst-32569	46	5	data	datum	NOUN
ajst-32569	46	6	has	have	VERB
ajst-32569	46	7	limited	limit	VERB
ajst-32569	46	8	accuracy	accuracy	NOUN
ajst-32569	46	9	in	in	ADP
ajst-32569	46	10	predicting	predict	VERB
ajst-32569	46	11	whether	whether	SCONJ
ajst-32569	46	12	an	an	DET
ajst-32569	46	13	individual	individual	NOUN
ajst-32569	46	14	has	have	VERB
ajst-32569	46	15	the	the	DET
ajst-32569	46	16	disease	disease	NOUN
ajst-32569	46	17	.	.	PUNCT
ajst-32569	47	1	the	the	DET
ajst-32569	47	2	current	current	ADJ
ajst-32569	47	3	trend	trend	NOUN
ajst-32569	47	4	is	be	AUX
ajst-32569	47	5	to	to	PART
ajst-32569	47	6	combine	combine	VERB
ajst-32569	47	7	structural	structural	ADJ
ajst-32569	47	8	data	datum	NOUN
ajst-32569	47	9	with	with	ADP
ajst-32569	47	10	functional	functional	ADJ
ajst-32569	47	11	connectivity	connectivity	NOUN
ajst-32569	47	12	,	,	PUNCT
ajst-32569	47	13	diffusion	diffusion	NOUN
ajst-32569	47	14	tensor	tensor	NOUN
ajst-32569	47	15	imaging	imaging	NOUN
ajst-32569	47	16	(	(	PUNCT
ajst-32569	47	17	dti	dti	PROPN
ajst-32569	47	18	,	,	PUNCT
ajst-32569	47	19	for	for	ADP
ajst-32569	47	20	measuring	measure	VERB
ajst-32569	47	21	white	white	ADJ
ajst-32569	47	22	matter	matter	NOUN
ajst-32569	47	23	fiber	fiber	NOUN
ajst-32569	47	24	integrity	integrity	NOUN
ajst-32569	47	25	)	)	PUNCT
ajst-32569	47	26	,	,	PUNCT
ajst-32569	47	27	and	and	CCONJ
ajst-32569	47	28	genetic	genetic	ADJ
ajst-32569	47	29	data	datum	NOUN
ajst-32569	47	30	to	to	PART
ajst-32569	47	31	build	build	VERB
ajst-32569	47	32	multimodal	multimodal	ADJ
ajst-32569	47	33	predictive	predictive	ADJ
ajst-32569	47	34	models	model	NOUN
ajst-32569	47	35	.	.	PUNCT
ajst-32569	48	1	machine	machine	NOUN
ajst-32569	48	2	learning	learn	VERB
ajst-32569	48	3	algorithms	algorithm	NOUN
ajst-32569	48	4	can	can	AUX
ajst-32569	48	5	use	use	VERB
ajst-32569	48	6	these	these	DET
ajst-32569	48	7	multidimensional	multidimensional	ADJ
ajst-32569	48	8	data	datum	NOUN
ajst-32569	48	9	to	to	PART
ajst-32569	48	10	more	more	ADV
ajst-32569	48	11	accurately	accurately	ADV
ajst-32569	48	12	distinguish	distinguish	VERB
ajst-32569	48	13	patients	patient	NOUN
ajst-32569	48	14	from	from	ADP
ajst-32569	48	15	controls	control	NOUN
ajst-32569	48	16	and	and	CCONJ
ajst-32569	48	17	predict	predict	VERB
ajst-32569	48	18	treatment	treatment	NOUN
ajst-32569	48	19	response	response	NOUN
ajst-32569	49	1	[	[	X
ajst-32569	49	2	11	11	NUM
ajst-32569	49	3	]	]	PUNCT
ajst-32569	49	4	.	.	PUNCT
ajst-32569	50	1	insights	insight	NOUN
ajst-32569	50	2	into	into	ADP
ajst-32569	50	3	microstructure	microstructure	NOUN
ajst-32569	50	4	.	.	PUNCT
ajst-32569	51	1	emerging	emerge	VERB
ajst-32569	51	2	magnetic	magnetic	ADJ
ajst-32569	51	3	resonance	resonance	NOUN
ajst-32569	51	4	spectroscopy	spectroscopy	NOUN
ajst-32569	51	5	(	(	PUNCT
ajst-32569	51	6	mrs	mrs	PROPN
ajst-32569	51	7	)	)	PUNCT
ajst-32569	51	8	studies	study	NOUN
ajst-32569	51	9	allow	allow	VERB
ajst-32569	51	10	in	in	ADP
ajst-32569	51	11	vivo	vivo	ADJ
ajst-32569	51	12	measurement	measurement	NOUN
ajst-32569	51	13	of	of	ADP
ajst-32569	51	14	brain	brain	NOUN
ajst-32569	51	15	chemical	chemical	NOUN
ajst-32569	51	16	concentrations	concentration	NOUN
ajst-32569	51	17	.	.	PUNCT
ajst-32569	52	1	studies	study	NOUN
ajst-32569	52	2	have	have	AUX
ajst-32569	52	3	found	find	VERB
ajst-32569	52	4	abnormalities	abnormality	NOUN
ajst-32569	52	5	in	in	ADP
ajst-32569	52	6	glutamate	glutamate	NOUN
ajst-32569	52	7	(	(	PUNCT
ajst-32569	52	8	glu	glu	NOUN
ajst-32569	52	9	)	)	PUNCT
ajst-32569	52	10	and	and	CCONJ
ajst-32569	52	11	γ	γ	NOUN
ajst-32569	52	12	-	-	ADJ
ajst-32569	52	13	aminobutyric	aminobutyric	ADJ
ajst-32569	52	14	acid	acid	NOUN
ajst-32569	52	15	(	(	PUNCT
ajst-32569	52	16	gaba	gaba	NOUN
ajst-32569	52	17	)	)	PUNCT
ajst-32569	52	18	levels	level	NOUN
ajst-32569	52	19	in	in	ADP
ajst-32569	52	20	brain	brain	NOUN
ajst-32569	52	21	regions	region	NOUN
ajst-32569	52	22	such	such	ADJ
ajst-32569	52	23	as	as	ADP
ajst-32569	52	24	the	the	DET
ajst-32569	52	25	pfc	pfc	NOUN
ajst-32569	52	26	and	and	CCONJ
ajst-32569	52	27	hippocampus	hippocampus	NOUN
ajst-32569	52	28	in	in	ADP
ajst-32569	52	29	mdd	mdd	PROPN
ajst-32569	52	30	patients	patient	NOUN
ajst-32569	52	31	,	,	PUNCT
ajst-32569	52	32	suggesting	suggest	VERB
ajst-32569	52	33	that	that	SCONJ
ajst-32569	52	34	excitatory	excitatory	NOUN
ajst-32569	52	35	/	/	SYM
ajst-32569	52	36	inhibitory	inhibitory	ADJ
ajst-32569	52	37	imbalance	imbalance	NOUN
ajst-32569	52	38	may	may	AUX
ajst-32569	52	39	be	be	AUX
ajst-32569	52	40	the	the	DET
ajst-32569	52	41	underlying	underlying	ADJ
ajst-32569	52	42	chemical	chemical	NOUN
ajst-32569	52	43	basis	basis	NOUN
ajst-32569	52	44	leading	lead	VERB
ajst-32569	52	45	to	to	ADP
ajst-32569	52	46	neuronal	neuronal	ADJ
ajst-32569	52	47	atrophy	atrophy	NOUN
ajst-32569	52	48	and	and	CCONJ
ajst-32569	52	49	network	network	NOUN
ajst-32569	52	50	dysfunction	dysfunction	NOUN
ajst-32569	52	51	.	.	PUNCT
ajst-32569	53	1	in	in	ADP
ajst-32569	53	2	summary	summary	NOUN
ajst-32569	53	3	,	,	PUNCT
ajst-32569	53	4	brain	brain	NOUN
ajst-32569	53	5	structural	structural	ADJ
ajst-32569	53	6	abnormalities	abnormality	NOUN
ajst-32569	53	7	are	be	AUX
ajst-32569	53	8	a	a	DET
ajst-32569	53	9	core	core	ADJ
ajst-32569	53	10	neurophysiological	neurophysiological	ADJ
ajst-32569	53	11	basis	basis	NOUN
ajst-32569	53	12	of	of	ADP
ajst-32569	53	13	depression	depression	NOUN
ajst-32569	53	14	.	.	PUNCT
ajst-32569	54	1	the	the	DET
ajst-32569	54	2	research	research	NOUN
ajst-32569	54	3	paradigm	paradigm	NOUN
ajst-32569	54	4	has	have	AUX
ajst-32569	54	5	evolved	evolve	VERB
ajst-32569	54	6	from	from	ADP
ajst-32569	54	7	macroscopic	macroscopic	ADJ
ajst-32569	54	8	volume	volume	NOUN
ajst-32569	54	9	measurement	measurement	NOUN
ajst-32569	54	10	to	to	ADP
ajst-32569	54	11	exploring	explore	VERB
ajst-32569	54	12	specific	specific	ADJ
ajst-32569	54	13	subregions	subregion	NOUN
ajst-32569	54	14	,	,	PUNCT
ajst-32569	54	15	microstructure	microstructure	NOUN
ajst-32569	54	16	,	,	PUNCT
ajst-32569	54	17	and	and	CCONJ
ajst-32569	54	18	dynamic	dynamic	ADJ
ajst-32569	54	19	circuits	circuit	NOUN
ajst-32569	54	20	.	.	PUNCT
ajst-32569	55	1	in	in	ADP
ajst-32569	55	2	the	the	DET
ajst-32569	55	3	future	future	NOUN
ajst-32569	55	4	,	,	PUNCT
ajst-32569	55	5	through	through	ADP
ajst-32569	55	6	large	large	ADJ
ajst-32569	55	7	samples	sample	NOUN
ajst-32569	55	8	,	,	PUNCT
ajst-32569	55	9	longitudinal	longitudinal	ADJ
ajst-32569	55	10	designs	design	NOUN
ajst-32569	55	11	,	,	PUNCT
ajst-32569	55	12	and	and	CCONJ
ajst-32569	55	13	multimodal	multimodal	NOUN
ajst-32569	55	14	data	datum	NOUN
ajst-32569	55	15	fusion	fusion	NOUN
ajst-32569	55	16	,	,	PUNCT
ajst-32569	55	17	we	we	PRON
ajst-32569	55	18	will	will	AUX
ajst-32569	55	19	more	more	ADV
ajst-32569	55	20	precisely	precisely	ADV
ajst-32569	55	21	map	map	VERB
ajst-32569	55	22	the	the	DET
ajst-32569	55	23	neuroanatomical	neuroanatomical	ADJ
ajst-32569	55	24	atlas	atla	NOUN
ajst-32569	55	25	of	of	ADP
ajst-32569	55	26	depression	depression	NOUN
ajst-32569	55	27	,	,	PUNCT
ajst-32569	55	28	laying	lay	VERB
ajst-32569	55	29	the	the	DET
ajst-32569	55	30	foundation	foundation	NOUN
ajst-32569	55	31	for	for	ADP
ajst-32569	55	32	biomarker	biomarker	NOUN
ajst-32569	55	33	-	-	PUNCT
ajst-32569	55	34	based	base	VERB
ajst-32569	55	35	precise	precise	ADJ
ajst-32569	55	36	diagnosis	diagnosis	NOUN
ajst-32569	55	37	and	and	CCONJ
ajst-32569	55	38	treatment	treatment	NOUN
ajst-32569	55	39	.	.	PUNCT
ajst-32569	56	1	3	3	X
ajst-32569	56	2	.	.	X
ajst-32569	56	3	neuroinflammatory	neuroinflammatory	ADJ
ajst-32569	56	4	mechanisms	mechanism	NOUN
ajst-32569	56	5	and	and	CCONJ
ajst-32569	56	6	depression	depression	NOUN
ajst-32569	56	7	a	a	DET
ajst-32569	56	8	large	large	ADJ
ajst-32569	56	9	number	number	NOUN
ajst-32569	56	10	of	of	ADP
ajst-32569	56	11	clinical	clinical	ADJ
ajst-32569	56	12	studies	study	NOUN
ajst-32569	56	13	have	have	AUX
ajst-32569	56	14	confirmed	confirm	VERB
ajst-32569	56	15	a	a	DET
ajst-32569	56	16	strong	strong	ADJ
ajst-32569	56	17	association	association	NOUN
ajst-32569	56	18	between	between	ADP
ajst-32569	56	19	inflammation	inflammation	NOUN
ajst-32569	56	20	and	and	CCONJ
ajst-32569	56	21	depression	depression	NOUN
ajst-32569	56	22	.	.	PUNCT
ajst-32569	57	1	a	a	PRON
ajst-32569	57	2	meta	meta	ADJ
ajst-32569	57	3	-	-	PUNCT
ajst-32569	57	4	analysis	analysis	NOUN
ajst-32569	57	5	incorporating	incorporate	VERB
ajst-32569	57	6	multiple	multiple	ADJ
ajst-32569	57	7	studies	study	NOUN
ajst-32569	57	8	showed	show	VERB
ajst-32569	57	9	that	that	SCONJ
ajst-32569	57	10	approximately	approximately	ADV
ajst-32569	57	11	27%-35	27%-35	NUM
ajst-32569	57	12	%	%	NOUN
ajst-32569	57	13	of	of	ADP
ajst-32569	57	14	mdd	mdd	PROPN
ajst-32569	57	15	patients	patient	NOUN
ajst-32569	57	16	have	have	VERB
ajst-32569	57	17	significantly	significantly	ADV
ajst-32569	57	18	elevated	elevate	VERB
ajst-32569	57	19	levels	level	NOUN
ajst-32569	57	20	of	of	ADP
ajst-32569	57	21	pro	pro	ADJ
ajst-32569	57	22	-	-	ADJ
ajst-32569	57	23	inflammatory	inflammatory	ADJ
ajst-32569	57	24	cytokines	cytokine	NOUN
ajst-32569	57	25	(	(	PUNCT
ajst-32569	57	26	such	such	ADJ
ajst-32569	57	27	as	as	ADP
ajst-32569	57	28	il-6	il-6	NOUN
ajst-32569	57	29	,	,	PUNCT
ajst-32569	57	30	tnfα	tnfα	NOUN
ajst-32569	57	31	,	,	PUNCT
ajst-32569	57	32	il-1β	il-1β	PROPN
ajst-32569	57	33	)	)	PUNCT
ajst-32569	57	34	and	and	CCONJ
ajst-32569	57	35	crp	crp	PROPN
ajst-32569	57	36	in	in	ADP
ajst-32569	57	37	peripheral	peripheral	ADJ
ajst-32569	57	38	blood	blood	NOUN
ajst-32569	58	1	[	[	X
ajst-32569	58	2	12	12	NUM
ajst-32569	58	3	-	-	SYM
ajst-32569	58	4	13	13	NUM
ajst-32569	58	5	]	]	PUNCT
ajst-32569	58	6	.	.	PUNCT
ajst-32569	59	1	the	the	DET
ajst-32569	59	2	association	association	NOUN
ajst-32569	59	3	is	be	AUX
ajst-32569	59	4	bidirectional	bidirectional	ADJ
ajst-32569	59	5	.	.	PUNCT
ajst-32569	60	1	inflammation	inflammation	NOUN
ajst-32569	60	2	can	can	AUX
ajst-32569	60	3	induce	induce	VERB
ajst-32569	60	4	depression	depression	NOUN
ajst-32569	60	5	;	;	PUNCT
ajst-32569	60	6	hepatitis	hepatitis	NOUN
ajst-32569	60	7	or	or	CCONJ
ajst-32569	60	8	cancer	cancer	NOUN
ajst-32569	60	9	patients	patient	NOUN
ajst-32569	60	10	receiving	receive	VERB
ajst-32569	60	11	interferon	interferon	ADJ
ajst-32569	60	12	-	-	PUNCT
ajst-32569	60	13	alpha	alpha	NOUN
ajst-32569	60	14	(	(	PUNCT
ajst-32569	60	15	ifn	ifn	PROPN
ajst-32569	60	16	-	-	PUNCT
ajst-32569	60	17	α	α	NOUN
ajst-32569	60	18	)	)	PUNCT
ajst-32569	60	19	therapy	therapy	NOUN
ajst-32569	60	20	have	have	VERB
ajst-32569	60	21	a	a	DET
ajst-32569	60	22	significantly	significantly	ADV
ajst-32569	60	23	higher	high	ADJ
ajst-32569	60	24	incidence	incidence	NOUN
ajst-32569	60	25	of	of	ADP
ajst-32569	60	26	depression	depression	NOUN
ajst-32569	60	27	than	than	ADP
ajst-32569	60	28	control	control	NOUN
ajst-32569	60	29	groups	group	NOUN
ajst-32569	60	30	,	,	PUNCT
ajst-32569	60	31	providing	provide	VERB
ajst-32569	60	32	the	the	DET
ajst-32569	60	33	most	most	ADV
ajst-32569	60	34	direct	direct	ADJ
ajst-32569	60	35	human	human	ADJ
ajst-32569	60	36	evidence	evidence	NOUN
ajst-32569	60	37	that	that	SCONJ
ajst-32569	60	38	"	"	PUNCT
ajst-32569	60	39	inflammation	inflammation	NOUN
ajst-32569	60	40	can	can	AUX
ajst-32569	60	41	cause	cause	VERB
ajst-32569	60	42	depression"[14	depression"[14	PROPN
ajst-32569	60	43	]	]	PUNCT
ajst-32569	60	44	.	.	PUNCT
ajst-32569	61	1	depression	depression	NOUN
ajst-32569	61	2	is	be	AUX
ajst-32569	61	3	also	also	ADV
ajst-32569	61	4	accompanied	accompany	VERB
ajst-32569	61	5	by	by	ADP
ajst-32569	61	6	inflammation	inflammation	NOUN
ajst-32569	61	7	;	;	PUNCT
ajst-32569	61	8	mdd	mdd	PROPN
ajst-32569	61	9	patients	patient	NOUN
ajst-32569	61	10	,	,	PUNCT
ajst-32569	61	11	especially	especially	ADV
ajst-32569	61	12	those	those	PRON
ajst-32569	61	13	with	with	ADP
ajst-32569	61	14	symptoms	symptom	NOUN
ajst-32569	61	15	such	such	ADJ
ajst-32569	61	16	as	as	ADP
ajst-32569	61	17	anorexia	anorexia	ADJ
ajst-32569	61	18	,	,	PUNCT
ajst-32569	61	19	fatigue	fatigue	NOUN
ajst-32569	61	20	,	,	PUNCT
ajst-32569	61	21	and	and	CCONJ
ajst-32569	61	22	anhedonia	anhedonia	NOUN
ajst-32569	61	23	—	—	PUNCT
ajst-32569	61	24	collectively	collectively	ADV
ajst-32569	61	25	known	know	VERB
ajst-32569	61	26	as	as	ADP
ajst-32569	61	27	"	"	PUNCT
ajst-32569	61	28	sickness	sickness	NOUN
ajst-32569	61	29	behavior"—have	behavior"—have	NOUN
ajst-32569	61	30	higher	high	ADJ
ajst-32569	61	31	levels	level	NOUN
ajst-32569	61	32	of	of	ADP
ajst-32569	61	33	inflammatory	inflammatory	ADJ
ajst-32569	61	34	markers	marker	NOUN
ajst-32569	61	35	.	.	PUNCT
ajst-32569	62	1	inflammatory	inflammatory	ADJ
ajst-32569	62	2	cytokines	cytokine	NOUN
ajst-32569	62	3	trigger	trigger	NOUN
ajst-32569	62	4	depressive	depressive	ADJ
ajst-32569	62	5	symptoms	symptom	NOUN
ajst-32569	62	6	by	by	ADP
ajst-32569	62	7	affecting	affect	VERB
ajst-32569	62	8	several	several	ADJ
ajst-32569	62	9	key	key	ADJ
ajst-32569	62	10	physiological	physiological	ADJ
ajst-32569	62	11	processes	process	NOUN
ajst-32569	62	12	:	:	PUNCT
ajst-32569	62	13	affecting	affect	VERB
ajst-32569	62	14	monoaminergic	monoaminergic	ADJ
ajst-32569	62	15	neurotransmitter	neurotransmitter	NOUN
ajst-32569	62	16	metabolism.inflammation	metabolism.inflammation	PROPN
ajst-32569	62	17	activates	activate	VERB
ajst-32569	62	18	the	the	DET
ajst-32569	62	19	enzyme	enzyme	NOUN
ajst-32569	62	20	indoleamine	indoleamine	NOUN
ajst-32569	62	21	2,3	2,3	NUM
ajst-32569	62	22	-	-	NOUN
ajst-32569	62	23	dioxygenase	dioxygenase	NOUN
ajst-32569	62	24	(	(	PUNCT
ajst-32569	62	25	ido	ido	PROPN
ajst-32569	62	26	)	)	PUNCT
ajst-32569	62	27	,	,	PUNCT
ajst-32569	62	28	which	which	DET
ajst-32569	62	29	shifts	shift	NOUN
ajst-32569	62	30	the	the	DET
ajst-32569	62	31	metabolic	metabolic	NOUN
ajst-32569	62	32	pathway	pathway	NOUN
ajst-32569	62	33	of	of	ADP
ajst-32569	62	34	tryptophan	tryptophan	NOUN
ajst-32569	62	35	(	(	PUNCT
ajst-32569	62	36	the	the	DET
ajst-32569	62	37	precursor	precursor	NOUN
ajst-32569	62	38	of	of	ADP
ajst-32569	62	39	5	5	NUM
ajst-32569	62	40	-	-	SYM
ajst-32569	62	41	ht	ht	NOUN
ajst-32569	62	42	)	)	PUNCT
ajst-32569	62	43	from	from	ADP
ajst-32569	62	44	producing	produce	VERB
ajst-32569	62	45	5	5	NUM
ajst-32569	62	46	-	-	PUNCT
ajst-32569	62	47	ht	ht	NOUN
ajst-32569	62	48	to	to	ADP
ajst-32569	62	49	generating	generate	VERB
ajst-32569	62	50	kynurenine	kynurenine	NOUN
ajst-32569	62	51	.	.	PUNCT
ajst-32569	63	1	kynurenine	kynurenine	PROPN
ajst-32569	63	2	can	can	AUX
ajst-32569	63	3	be	be	AUX
ajst-32569	63	4	further	far	ADV
ajst-32569	63	5	metabolized	metabolize	VERB
ajst-32569	63	6	into	into	ADP
ajst-32569	63	7	neurotoxic	neurotoxic	ADJ
ajst-32569	63	8	quinolinic	quinolinic	ADJ
ajst-32569	63	9	acid	acid	NOUN
ajst-32569	63	10	(	(	PUNCT
ajst-32569	63	11	which	which	PRON
ajst-32569	63	12	acts	act	VERB
ajst-32569	63	13	as	as	ADP
ajst-32569	63	14	an	an	DET
ajst-32569	63	15	nmda	nmda	ADJ
ajst-32569	63	16	receptor	receptor	NOUN
ajst-32569	63	17	agonist	agonist	NOUN
ajst-32569	63	18	,	,	PUNCT
ajst-32569	63	19	causing	cause	VERB
ajst-32569	63	20	excitotoxicity	excitotoxicity	NOUN
ajst-32569	63	21	)	)	PUNCT
ajst-32569	63	22	and	and	CCONJ
ajst-32569	63	23	3hydroxykynurenine	3hydroxykynurenine	NUM
ajst-32569	63	24	(	(	PUNCT
ajst-32569	63	25	3	3	NUM
ajst-32569	63	26	-	-	SYM
ajst-32569	63	27	hk	hk	NOUN
ajst-32569	63	28	)	)	PUNCT
ajst-32569	63	29	(	(	PUNCT
ajst-32569	63	30	producing	produce	VERB
ajst-32569	63	31	reactive	reactive	ADJ
ajst-32569	63	32	oxygen	oxygen	NOUN
ajst-32569	63	33	species	specie	NOUN
ajst-32569	63	34	)	)	PUNCT
ajst-32569	63	35	,	,	PUNCT
ajst-32569	63	36	while	while	SCONJ
ajst-32569	63	37	reducing	reduce	VERB
ajst-32569	63	38	the	the	DET
ajst-32569	63	39	production	production	NOUN
ajst-32569	63	40	of	of	ADP
ajst-32569	63	41	neuroprotective	neuroprotective	ADJ
ajst-32569	63	42	kynurenic	kynurenic	ADJ
ajst-32569	63	43	acid	acid	NOUN
ajst-32569	63	44	.	.	PUNCT
ajst-32569	64	1	this	this	PRON
ajst-32569	64	2	leads	lead	VERB
ajst-32569	64	3	to	to	ADP
ajst-32569	64	4	monoamine	monoamine	ADJ
ajst-32569	64	5	depletion	depletion	NOUN
ajst-32569	64	6	,	,	PUNCT
ajst-32569	64	7	oxidative	oxidative	ADJ
ajst-32569	64	8	stress	stress	NOUN
ajst-32569	64	9	,	,	PUNCT
ajst-32569	64	10	and	and	CCONJ
ajst-32569	64	11	neuronal	neuronal	ADJ
ajst-32569	64	12	damage	damage	NOUN
ajst-32569	64	13	[	[	X
ajst-32569	64	14	15	15	NUM
ajst-32569	64	15	]	]	PUNCT
ajst-32569	64	16	.	.	PUNCT
ajst-32569	65	1	disrupting	disrupt	VERB
ajst-32569	65	2	hpa	hpa	NOUN
ajst-32569	65	3	axis	axis	NOUN
ajst-32569	65	4	function	function	NOUN
ajst-32569	65	5	.	.	PUNCT
ajst-32569	66	1	cytokines	cytokine	NOUN
ajst-32569	66	2	can	can	AUX
ajst-32569	66	3	stimulate	stimulate	VERB
ajst-32569	66	4	the	the	DET
ajst-32569	66	5	hypothalamus	hypothalamus	NOUN
ajst-32569	66	6	to	to	PART
ajst-32569	66	7	release	release	VERB
ajst-32569	66	8	corticotropin	corticotropin	NOUN
ajst-32569	66	9	-	-	PUNCT
ajst-32569	66	10	releasing	release	VERB
ajst-32569	66	11	hormone	hormone	NOUN
ajst-32569	66	12	(	(	PUNCT
ajst-32569	66	13	crh	crh	PROPN
ajst-32569	66	14	)	)	PUNCT
ajst-32569	66	15	,	,	PUNCT
ajst-32569	66	16	leading	lead	VERB
ajst-32569	66	17	to	to	ADP
ajst-32569	66	18	persistent	persistent	ADJ
ajst-32569	66	19	hpa	hpa	NOUN
ajst-32569	66	20	axis	axis	NOUN
ajst-32569	66	21	hyperactivity	hyperactivity	NOUN
ajst-32569	66	22	and	and	CCONJ
ajst-32569	66	23	glucocorticoid	glucocorticoid	ADJ
ajst-32569	66	24	(	(	PUNCT
ajst-32569	66	25	cortisol	cortisol	NOUN
ajst-32569	66	26	)	)	PUNCT
ajst-32569	66	27	resistance	resistance	NOUN
ajst-32569	66	28	,	,	PUNCT
ajst-32569	66	29	causing	cause	VERB
ajst-32569	66	30	its	its	PRON
ajst-32569	66	31	negative	negative	ADJ
ajst-32569	66	32	feedback	feedback	NOUN
ajst-32569	66	33	regulation	regulation	NOUN
ajst-32569	66	34	to	to	PART
ajst-32569	66	35	fail	fail	VERB
ajst-32569	66	36	,	,	PUNCT
ajst-32569	66	37	further	far	ADV
ajst-32569	66	38	exacerbating	exacerbate	VERB
ajst-32569	66	39	inflammation	inflammation	NOUN
ajst-32569	66	40	and	and	CCONJ
ajst-32569	66	41	neurotoxicity	neurotoxicity	NOUN
ajst-32569	66	42	.	.	PUNCT
ajst-32569	67	1	inhibiting	inhibit	VERB
ajst-32569	67	2	neurotrophic	neurotrophic	ADJ
ajst-32569	67	3	support	support	NOUN
ajst-32569	67	4	.	.	PUNCT
ajst-32569	68	1	inflammatory	inflammatory	ADJ
ajst-32569	68	2	signals	signal	NOUN
ajst-32569	68	3	(	(	PUNCT
ajst-32569	68	4	especially	especially	ADV
ajst-32569	68	5	tnf	tnf	PROPN
ajst-32569	68	6	-	-	PUNCT
ajst-32569	68	7	α	α	NOUN
ajst-32569	68	8	)	)	PUNCT
ajst-32569	68	9	can	can	AUX
ajst-32569	68	10	significantly	significantly	ADV
ajst-32569	68	11	downregulate	downregulate	VERB
ajst-32569	68	12	the	the	DET
ajst-32569	68	13	expression	expression	NOUN
ajst-32569	68	14	and	and	CCONJ
ajst-32569	68	15	function	function	NOUN
ajst-32569	68	16	of	of	ADP
ajst-32569	68	17	brain	brain	NOUN
ajst-32569	68	18	-	-	PUNCT
ajst-32569	68	19	derived	derive	VERB
ajst-32569	68	20	neurotrophic	neurotrophic	ADJ
ajst-32569	68	21	factor	factor	NOUN
ajst-32569	68	22	(	(	PUNCT
ajst-32569	68	23	bdnf	bdnf	PROPN
ajst-32569	68	24	)	)	PUNCT
ajst-32569	68	25	.	.	PUNCT
ajst-32569	69	1	bdnf	bdnf	PROPN
ajst-32569	69	2	is	be	AUX
ajst-32569	69	3	a	a	DET
ajst-32569	69	4	key	key	ADJ
ajst-32569	69	5	molecule	molecule	NOUN
ajst-32569	69	6	for	for	ADP
ajst-32569	69	7	maintaining	maintain	VERB
ajst-32569	69	8	neuronal	neuronal	ADJ
ajst-32569	69	9	health	health	NOUN
ajst-32569	69	10	,	,	PUNCT
ajst-32569	69	11	synaptic	synaptic	ADJ
ajst-32569	69	12	plasticity	plasticity	NOUN
ajst-32569	69	13	,	,	PUNCT
ajst-32569	69	14	and	and	CCONJ
ajst-32569	69	15	neurogenesis	neurogenesis	VERB
ajst-32569	69	16	.	.	PUNCT
ajst-32569	70	1	its	its	PRON
ajst-32569	70	2	reduction	reduction	NOUN
ajst-32569	70	3	166	166	NUM
ajst-32569	70	4	directly	directly	ADV
ajst-32569	70	5	leads	lead	VERB
ajst-32569	70	6	to	to	ADP
ajst-32569	70	7	impaired	impaired	ADJ
ajst-32569	70	8	neurogenesis	neurogenesis	NOUN
ajst-32569	70	9	and	and	CCONJ
ajst-32569	70	10	synaptic	synaptic	ADJ
ajst-32569	70	11	loss	loss	NOUN
ajst-32569	70	12	in	in	ADP
ajst-32569	70	13	the	the	DET
ajst-32569	70	14	hippocampus	hippocampus	NOUN
ajst-32569	70	15	and	and	CCONJ
ajst-32569	70	16	prefrontal	prefrontal	ADJ
ajst-32569	70	17	cortex	cortex	NOUN
ajst-32569	70	18	,	,	PUNCT
ajst-32569	70	19	directly	directly	ADV
ajst-32569	70	20	linking	link	VERB
ajst-32569	70	21	to	to	ADP
ajst-32569	70	22	the	the	DET
ajst-32569	70	23	brain	brain	NOUN
ajst-32569	70	24	structural	structural	ADJ
ajst-32569	70	25	abnormalities	abnormality	NOUN
ajst-32569	70	26	discussed	discuss	VERB
ajst-32569	70	27	in	in	ADP
ajst-32569	70	28	the	the	DET
ajst-32569	70	29	previous	previous	ADJ
ajst-32569	70	30	chapter	chapter	NOUN
ajst-32569	70	31	.	.	PUNCT
ajst-32569	71	1	altering	alter	VERB
ajst-32569	71	2	reward	reward	NOUN
ajst-32569	71	3	circuit	circuit	NOUN
ajst-32569	71	4	function	function	NOUN
ajst-32569	71	5	.	.	PUNCT
ajst-32569	72	1	inflammatory	inflammatory	ADJ
ajst-32569	72	2	cytokines	cytokine	NOUN
ajst-32569	72	3	can	can	AUX
ajst-32569	72	4	reduce	reduce	VERB
ajst-32569	72	5	the	the	DET
ajst-32569	72	6	activity	activity	NOUN
ajst-32569	72	7	of	of	ADP
ajst-32569	72	8	dopamine	dopamine	NOUN
ajst-32569	72	9	neurons	neuron	NOUN
ajst-32569	72	10	in	in	ADP
ajst-32569	72	11	the	the	DET
ajst-32569	72	12	ventral	ventral	ADJ
ajst-32569	72	13	tegmental	tegmental	ADJ
ajst-32569	72	14	area	area	NOUN
ajst-32569	72	15	(	(	PUNCT
ajst-32569	72	16	vta)and	vta)and	NOUN
ajst-32569	72	17	dopamine	dopamine	NOUN
ajst-32569	72	18	release	release	NOUN
ajst-32569	72	19	in	in	ADP
ajst-32569	72	20	the	the	DET
ajst-32569	72	21	nucleus	nucleus	NOUN
ajst-32569	72	22	accumbens	accumben	NOUN
ajst-32569	72	23	(	(	PUNCT
ajst-32569	72	24	nacc	nacc	ADV
ajst-32569	72	25	)	)	PUNCT
ajst-32569	72	26	,	,	PUNCT
ajst-32569	72	27	which	which	PRON
ajst-32569	72	28	is	be	AUX
ajst-32569	72	29	the	the	DET
ajst-32569	72	30	direct	direct	ADJ
ajst-32569	72	31	cause	cause	NOUN
ajst-32569	72	32	of	of	ADP
ajst-32569	72	33	the	the	DET
ajst-32569	72	34	core	core	NOUN
ajst-32569	72	35	symptom	symptom	NOUN
ajst-32569	72	36	of	of	ADP
ajst-32569	72	37	anhedonia	anhedonia	NOUN
ajst-32569	72	38	.	.	PUNCT
ajst-32569	73	1	research	research	NOUN
ajst-32569	73	2	in	in	ADP
ajst-32569	73	3	this	this	DET
ajst-32569	73	4	field	field	NOUN
ajst-32569	73	5	is	be	AUX
ajst-32569	73	6	moving	move	VERB
ajst-32569	73	7	from	from	ADP
ajst-32569	73	8	proving	prove	VERB
ajst-32569	73	9	association	association	NOUN
ajst-32569	73	10	to	to	PART
ajst-32569	73	11	deeply	deeply	ADV
ajst-32569	73	12	analyzing	analyze	VERB
ajst-32569	73	13	mechanistic	mechanistic	ADJ
ajst-32569	73	14	heterogeneity	heterogeneity	NOUN
ajst-32569	73	15	and	and	CCONJ
ajst-32569	73	16	developing	develop	VERB
ajst-32569	73	17	translational	translational	ADJ
ajst-32569	73	18	applications	application	NOUN
ajst-32569	73	19	.	.	PUNCT
ajst-32569	74	1	microglial	microglial	ADJ
ajst-32569	74	2	activation	activation	NOUN
ajst-32569	74	3	imaging.a	imaging.a	PROPN
ajst-32569	74	4	recent	recent	ADJ
ajst-32569	74	5	breakthrough	breakthrough	NOUN
ajst-32569	74	6	involves	involve	VERB
ajst-32569	74	7	using	use	VERB
ajst-32569	74	8	positron	positron	NOUN
ajst-32569	74	9	emission	emission	NOUN
ajst-32569	74	10	tomography	tomography	NOUN
ajst-32569	74	11	(	(	PUNCT
ajst-32569	74	12	pet)with	pet)with	NOUN
ajst-32569	74	13	specific	specific	ADJ
ajst-32569	74	14	tracers	tracer	NOUN
ajst-32569	74	15	(	(	PUNCT
ajst-32569	74	16	such	such	ADJ
ajst-32569	74	17	as	as	ADP
ajst-32569	74	18	pbr28	pbr28	NOUN
ajst-32569	74	19	,	,	PUNCT
ajst-32569	74	20	targeting	target	VERB
ajst-32569	74	21	the	the	DET
ajst-32569	74	22	tspo	tspo	NOUN
ajst-32569	74	23	protein	protein	NOUN
ajst-32569	74	24	)	)	PUNCT
ajst-32569	74	25	to	to	PART
ajst-32569	74	26	image	image	VERB
ajst-32569	74	27	the	the	DET
ajst-32569	74	28	activation	activation	NOUN
ajst-32569	74	29	of	of	ADP
ajst-32569	74	30	microglia	microglia	NOUN
ajst-32569	74	31	in	in	ADP
ajst-32569	74	32	the	the	DET
ajst-32569	74	33	living	live	VERB
ajst-32569	74	34	brain	brain	NOUN
ajst-32569	74	35	.	.	PUNCT
ajst-32569	75	1	several	several	ADJ
ajst-32569	75	2	studies	study	NOUN
ajst-32569	75	3	have	have	AUX
ajst-32569	75	4	reported	report	VERB
ajst-32569	75	5	increased	increase	VERB
ajst-32569	75	6	tspo	tspo	NOUN
ajst-32569	75	7	signal	signal	NOUN
ajst-32569	75	8	in	in	ADP
ajst-32569	75	9	brain	brain	NOUN
ajst-32569	75	10	regions	region	NOUN
ajst-32569	75	11	such	such	ADJ
ajst-32569	75	12	as	as	ADP
ajst-32569	75	13	the	the	DET
ajst-32569	75	14	prefrontal	prefrontal	ADJ
ajst-32569	75	15	cortex	cortex	NOUN
ajst-32569	75	16	,	,	PUNCT
ajst-32569	75	17	anterior	anterior	ADJ
ajst-32569	75	18	cingulate	cingulate	NOUN
ajst-32569	75	19	cortex	cortex	NOUN
ajst-32569	75	20	,	,	PUNCT
ajst-32569	75	21	and	and	CCONJ
ajst-32569	75	22	insula	insula	NOUN
ajst-32569	75	23	in	in	ADP
ajst-32569	75	24	mdd	mdd	PROPN
ajst-32569	75	25	patients	patient	NOUN
ajst-32569	75	26	,	,	PUNCT
ajst-32569	75	27	providing	provide	VERB
ajst-32569	75	28	the	the	DET
ajst-32569	75	29	most	most	ADV
ajst-32569	75	30	direct	direct	ADJ
ajst-32569	75	31	in	in	ADP
ajst-32569	75	32	vivo	vivo	ADJ
ajst-32569	75	33	evidence	evidence	NOUN
ajst-32569	75	34	for	for	ADP
ajst-32569	75	35	the	the	DET
ajst-32569	75	36	presence	presence	NOUN
ajst-32569	75	37	of	of	ADP
ajst-32569	75	38	central	central	ADJ
ajst-32569	75	39	neuroinflammation	neuroinflammation	NOUN
ajst-32569	76	1	[	[	X
ajst-32569	76	2	16	16	NUM
ajst-32569	76	3	-	-	SYM
ajst-32569	76	4	17	17	NUM
ajst-32569	76	5	]	]	PUNCT
ajst-32569	76	6	.	.	PUNCT
ajst-32569	77	1	however	however	ADV
ajst-32569	77	2	,	,	PUNCT
ajst-32569	77	3	results	result	NOUN
ajst-32569	77	4	are	be	AUX
ajst-32569	77	5	heterogeneous	heterogeneous	ADJ
ajst-32569	77	6	and	and	CCONJ
ajst-32569	77	7	may	may	AUX
ajst-32569	77	8	be	be	AUX
ajst-32569	77	9	related	relate	VERB
ajst-32569	77	10	to	to	ADP
ajst-32569	77	11	specific	specific	ADJ
ajst-32569	77	12	clinical	clinical	ADJ
ajst-32569	77	13	symptoms	symptom	NOUN
ajst-32569	77	14	or	or	CCONJ
ajst-32569	77	15	subtypes	subtype	NOUN
ajst-32569	77	16	.	.	PUNCT
ajst-32569	78	1	identification	identification	NOUN
ajst-32569	78	2	of	of	ADP
ajst-32569	78	3	inflammatory	inflammatory	ADJ
ajst-32569	78	4	subtypes.not	subtypes.not	ADV
ajst-32569	78	5	all	all	PRON
ajst-32569	78	6	depressed	depressed	ADJ
ajst-32569	78	7	patients	patient	NOUN
ajst-32569	78	8	have	have	VERB
ajst-32569	78	9	inflammation	inflammation	NOUN
ajst-32569	78	10	.	.	PUNCT
ajst-32569	79	1	research	research	NOUN
ajst-32569	79	2	is	be	AUX
ajst-32569	79	3	dedicated	dedicate	VERB
ajst-32569	79	4	to	to	ADP
ajst-32569	79	5	defining	define	VERB
ajst-32569	79	6	an	an	DET
ajst-32569	79	7	"	"	PUNCT
ajst-32569	79	8	inflammatory	inflammatory	ADJ
ajst-32569	79	9	subtype	subtype	NOUN
ajst-32569	79	10	"	"	PUNCT
ajst-32569	79	11	or	or	CCONJ
ajst-32569	79	12	"	"	PUNCT
ajst-32569	79	13	high	high	ADJ
ajst-32569	79	14	-	-	PUNCT
ajst-32569	79	15	inflammatory	inflammatory	ADJ
ajst-32569	79	16	biotype	biotype	NOUN
ajst-32569	79	17	"	"	PUNCT
ajst-32569	79	18	of	of	ADP
ajst-32569	79	19	depression	depression	NOUN
ajst-32569	79	20	.	.	PUNCT
ajst-32569	80	1	these	these	DET
ajst-32569	80	2	patients	patient	NOUN
ajst-32569	80	3	typically	typically	ADV
ajst-32569	80	4	have	have	VERB
ajst-32569	80	5	a	a	DET
ajst-32569	80	6	more	more	ADV
ajst-32569	80	7	specific	specific	ADJ
ajst-32569	80	8	symptom	symptom	NOUN
ajst-32569	80	9	profile	profile	NOUN
ajst-32569	80	10	(	(	PUNCT
ajst-32569	80	11	e.g.	e.g.	ADV
ajst-32569	80	12	,	,	PUNCT
ajst-32569	80	13	significant	significant	ADJ
ajst-32569	80	14	fatigue	fatigue	NOUN
ajst-32569	80	15	,	,	PUNCT
ajst-32569	80	16	psychomotor	psychomotor	NOUN
ajst-32569	80	17	retardation	retardation	NOUN
ajst-32569	80	18	,	,	PUNCT
ajst-32569	80	19	anhedonia	anhedonia	NOUN
ajst-32569	80	20	)	)	PUNCT
ajst-32569	80	21	,	,	PUNCT
ajst-32569	80	22	poorer	poor	ADJ
ajst-32569	80	23	treatment	treatment	NOUN
ajst-32569	80	24	response	response	NOUN
ajst-32569	80	25	,	,	PUNCT
ajst-32569	80	26	and	and	CCONJ
ajst-32569	80	27	resistance	resistance	NOUN
ajst-32569	80	28	to	to	ADP
ajst-32569	80	29	conventional	conventional	ADJ
ajst-32569	80	30	ssris	ssris	NOUN
ajst-32569	80	31	.	.	PUNCT
ajst-32569	81	1	identifying	identify	VERB
ajst-32569	81	2	such	such	ADJ
ajst-32569	81	3	biomarkers	biomarker	NOUN
ajst-32569	81	4	(	(	PUNCT
ajst-32569	81	5	e.g.	e.g.	ADV
ajst-32569	81	6	,	,	PUNCT
ajst-32569	81	7	high	high	ADJ
ajst-32569	81	8	crp	crp	NOUN
ajst-32569	81	9	)	)	PUNCT
ajst-32569	81	10	can	can	AUX
ajst-32569	81	11	guide	guide	VERB
ajst-32569	81	12	personalized	personalized	ADJ
ajst-32569	81	13	treatment	treatment	NOUN
ajst-32569	81	14	.	.	PUNCT
ajst-32569	82	1	exploration	exploration	NOUN
ajst-32569	82	2	of	of	ADP
ajst-32569	82	3	anti	anti	ADJ
ajst-32569	82	4	-	-	ADJ
ajst-32569	82	5	inflammatory	inflammatory	ADJ
ajst-32569	82	6	therapies	therapy	NOUN
ajst-32569	82	7	.	.	PUNCT
ajst-32569	83	1	numerous	numerous	ADJ
ajst-32569	83	2	clinical	clinical	ADJ
ajst-32569	83	3	trials	trial	NOUN
ajst-32569	83	4	are	be	AUX
ajst-32569	83	5	evaluating	evaluate	VERB
ajst-32569	83	6	the	the	DET
ajst-32569	83	7	efficacy	efficacy	NOUN
ajst-32569	83	8	of	of	ADP
ajst-32569	83	9	anti	anti	ADJ
ajst-32569	83	10	-	-	ADJ
ajst-32569	83	11	inflammatory	inflammatory	ADJ
ajst-32569	83	12	drugs	drug	NOUN
ajst-32569	83	13	(	(	PUNCT
ajst-32569	83	14	such	such	ADJ
ajst-32569	83	15	as	as	ADP
ajst-32569	83	16	the	the	DET
ajst-32569	83	17	anti	anti	ADJ
ajst-32569	83	18	-	-	ADJ
ajst-32569	83	19	tnf	tnf	ADJ
ajst-32569	83	20	-	-	PUNCT
ajst-32569	83	21	α	α	NOUN
ajst-32569	83	22	monoclonal	monoclonal	NOUN
ajst-32569	83	23	antibody	antibody	NOUN
ajst-32569	83	24	infliximab	infliximab	NOUN
ajst-32569	83	25	,	,	PUNCT
ajst-32569	83	26	and	and	CCONJ
ajst-32569	83	27	the	the	DET
ajst-32569	83	28	cox-2	cox-2	ADJ
ajst-32569	83	29	inhibitor	inhibitor	NOUN
ajst-32569	83	30	celecoxib	celecoxib	NOUN
ajst-32569	83	31	)	)	PUNCT
ajst-32569	83	32	as	as	ADP
ajst-32569	83	33	adjunctive	adjunctive	ADJ
ajst-32569	83	34	treatments	treatment	NOUN
ajst-32569	83	35	for	for	ADP
ajst-32569	83	36	mdd	mdd	PROPN
ajst-32569	83	37	.	.	PUNCT
ajst-32569	84	1	meta	meta	VERB
ajst-32569	84	2	-	-	PUNCT
ajst-32569	84	3	analyses	analysis	NOUN
ajst-32569	84	4	show	show	VERB
ajst-32569	84	5	that	that	PRON
ajst-32569	84	6	celecoxib	celecoxib	VERB
ajst-32569	84	7	,	,	PUNCT
ajst-32569	84	8	in	in	ADP
ajst-32569	84	9	particular	particular	ADJ
ajst-32569	84	10	,	,	PUNCT
ajst-32569	84	11	demonstrates	demonstrate	VERB
ajst-32569	84	12	clear	clear	ADJ
ajst-32569	84	13	antidepressant	antidepressant	ADJ
ajst-32569	84	14	efficacy	efficacy	NOUN
ajst-32569	84	15	,	,	PUNCT
ajst-32569	84	16	especially	especially	ADV
ajst-32569	84	17	in	in	ADP
ajst-32569	84	18	patients	patient	NOUN
ajst-32569	84	19	with	with	ADP
ajst-32569	84	20	high	high	ADJ
ajst-32569	84	21	baseline	baseline	ADJ
ajst-32569	84	22	inflammatory	inflammatory	ADJ
ajst-32569	84	23	marker	marker	NOUN
ajst-32569	84	24	levels	level	NOUN
ajst-32569	84	25	.	.	PUNCT
ajst-32569	85	1	gut	gut	VERB
ajst-32569	85	2	microbiota	microbiota	NOUN
ajst-32569	85	3	-	-	PUNCT
ajst-32569	85	4	immune	immune	NOUN
ajst-32569	85	5	-	-	PUNCT
ajst-32569	85	6	brain	brain	NOUN
ajst-32569	85	7	axis	axis	NOUN
ajst-32569	85	8	.	.	PUNCT
ajst-32569	86	1	recent	recent	ADJ
ajst-32569	86	2	research	research	NOUN
ajst-32569	86	3	has	have	AUX
ajst-32569	86	4	revealed	reveal	VERB
ajst-32569	86	5	the	the	DET
ajst-32569	86	6	key	key	ADJ
ajst-32569	86	7	role	role	NOUN
ajst-32569	86	8	of	of	ADP
ajst-32569	86	9	the	the	DET
ajst-32569	86	10	gut	gut	NOUN
ajst-32569	86	11	microbiome	microbiome	NOUN
ajst-32569	86	12	as	as	ADP
ajst-32569	86	13	an	an	DET
ajst-32569	86	14	immune	immune	ADJ
ajst-32569	86	15	regulator	regulator	NOUN
ajst-32569	86	16	.	.	PUNCT
ajst-32569	87	1	gut	gut	VERB
ajst-32569	87	2	microbiota	microbiota	NOUN
ajst-32569	87	3	dysbiosis	dysbiosis	NOUN
ajst-32569	87	4	can	can	AUX
ajst-32569	87	5	lead	lead	VERB
ajst-32569	87	6	to	to	ADP
ajst-32569	87	7	increased	increase	VERB
ajst-32569	87	8	intestinal	intestinal	ADJ
ajst-32569	87	9	permeability	permeability	NOUN
ajst-32569	87	10	(	(	PUNCT
ajst-32569	87	11	"	"	PUNCT
ajst-32569	87	12	leaky	leaky	ADJ
ajst-32569	87	13	gut	gut	NOUN
ajst-32569	87	14	"	"	PUNCT
ajst-32569	87	15	)	)	PUNCT
ajst-32569	87	16	,	,	PUNCT
ajst-32569	87	17	allowing	allow	VERB
ajst-32569	87	18	bacterial	bacterial	ADJ
ajst-32569	87	19	lipopolysaccharide	lipopolysaccharide	ADJ
ajst-32569	87	20	(	(	PUNCT
ajst-32569	87	21	lps	lps	PROPN
ajst-32569	87	22	)	)	PUNCT
ajst-32569	87	23	to	to	PART
ajst-32569	87	24	enter	enter	VERB
ajst-32569	87	25	the	the	DET
ajst-32569	87	26	circulation	circulation	NOUN
ajst-32569	87	27	,	,	PUNCT
ajst-32569	87	28	triggering	trigger	VERB
ajst-32569	87	29	systemic	systemic	ADJ
ajst-32569	87	30	low	low	ADJ
ajst-32569	87	31	-	-	PUNCT
ajst-32569	87	32	grade	grade	NOUN
ajst-32569	87	33	inflammation	inflammation	NOUN
ajst-32569	87	34	,	,	PUNCT
ajst-32569	87	35	which	which	PRON
ajst-32569	87	36	in	in	ADP
ajst-32569	87	37	turn	turn	NOUN
ajst-32569	87	38	affects	affect	VERB
ajst-32569	87	39	the	the	DET
ajst-32569	87	40	brain	brain	NOUN
ajst-32569	87	41	.	.	PUNCT
ajst-32569	88	1	probiotic	probiotic	ADJ
ajst-32569	88	2	and	and	CCONJ
ajst-32569	88	3	prebiotic	prebiotic	ADJ
ajst-32569	88	4	interventions	intervention	NOUN
ajst-32569	88	5	are	be	AUX
ajst-32569	88	6	regarded	regard	VERB
ajst-32569	88	7	as	as	ADP
ajst-32569	88	8	potential	potential	ADJ
ajst-32569	88	9	new	new	ADJ
ajst-32569	88	10	strategies	strategy	NOUN
ajst-32569	88	11	for	for	ADP
ajst-32569	88	12	modulating	modulate	VERB
ajst-32569	88	13	immunity	immunity	NOUN
ajst-32569	88	14	and	and	CCONJ
ajst-32569	88	15	improving	improve	VERB
ajst-32569	88	16	mood	mood	NOUN
ajst-32569	88	17	[	[	X
ajst-32569	88	18	18	18	NUM
ajst-32569	88	19	]	]	PUNCT
ajst-32569	88	20	.	.	PUNCT
ajst-32569	89	1	4	4	X
ajst-32569	89	2	.	.	X
ajst-32569	89	3	conclusion	conclusion	NOUN
ajst-32569	89	4	and	and	CCONJ
ajst-32569	89	5	perspectives	perspective	NOUN
ajst-32569	89	6	this	this	DET
ajst-32569	89	7	review	review	NOUN
ajst-32569	89	8	has	have	AUX
ajst-32569	89	9	systematically	systematically	ADV
ajst-32569	89	10	organized	organize	VERB
ajst-32569	89	11	the	the	DET
ajst-32569	89	12	two	two	NUM
ajst-32569	89	13	core	core	NOUN
ajst-32569	89	14	pillars	pillar	NOUN
ajst-32569	89	15	of	of	ADP
ajst-32569	89	16	research	research	NOUN
ajst-32569	89	17	on	on	ADP
ajst-32569	89	18	the	the	DET
ajst-32569	89	19	neurophysiological	neurophysiological	ADJ
ajst-32569	89	20	mechanisms	mechanism	NOUN
ajst-32569	89	21	of	of	ADP
ajst-32569	89	22	depression	depression	NOUN
ajst-32569	89	23	:	:	PUNCT
ajst-32569	89	24	brain	brain	NOUN
ajst-32569	89	25	structural	structural	ADJ
ajst-32569	89	26	abnormalities	abnormality	NOUN
ajst-32569	89	27	and	and	CCONJ
ajst-32569	89	28	neural	neural	ADJ
ajst-32569	89	29	circuit	circuit	NOUN
ajst-32569	89	30	dysfunction	dysfunction	NOUN
ajst-32569	89	31	,	,	PUNCT
ajst-32569	89	32	and	and	CCONJ
ajst-32569	89	33	neuroinflammatory	neuroinflammatory	ADJ
ajst-32569	89	34	mechanisms	mechanism	NOUN
ajst-32569	89	35	.	.	PUNCT
ajst-32569	90	1	evidence	evidence	NOUN
ajst-32569	90	2	indicates	indicate	VERB
ajst-32569	90	3	that	that	SCONJ
ajst-32569	90	4	depression	depression	NOUN
ajst-32569	90	5	is	be	AUX
ajst-32569	90	6	far	far	ADV
ajst-32569	90	7	from	from	ADP
ajst-32569	90	8	single	single	ADJ
ajst-32569	90	9	neurochemical	neurochemical	ADJ
ajst-32569	90	10	neurotransmitter	neurotransmitter	NOUN
ajst-32569	90	11	imbalance	imbalance	NOUN
ajst-32569	90	12	disease	disease	NOUN
ajst-32569	90	13	,	,	PUNCT
ajst-32569	90	14	but	but	CCONJ
ajst-32569	90	15	rather	rather	ADV
ajst-32569	90	16	a	a	DET
ajst-32569	90	17	complex	complex	ADJ
ajst-32569	90	18	syndrome	syndrome	NOUN
ajst-32569	90	19	arising	arise	VERB
ajst-32569	90	20	from	from	ADP
ajst-32569	90	21	the	the	DET
ajst-32569	90	22	interaction	interaction	NOUN
ajst-32569	90	23	of	of	ADP
ajst-32569	90	24	genetic	genetic	ADJ
ajst-32569	90	25	susceptibility	susceptibility	NOUN
ajst-32569	90	26	and	and	CCONJ
ajst-32569	90	27	environmental	environmental	ADJ
ajst-32569	90	28	stress	stress	NOUN
ajst-32569	90	29	factors	factor	NOUN
ajst-32569	90	30	,	,	PUNCT
ajst-32569	90	31	leading	lead	VERB
ajst-32569	90	32	to	to	ADP
ajst-32569	90	33	widespread	widespread	ADJ
ajst-32569	90	34	disorders	disorder	NOUN
ajst-32569	90	35	in	in	ADP
ajst-32569	90	36	three	three	NUM
ajst-32569	90	37	major	major	ADJ
ajst-32569	90	38	systems	system	NOUN
ajst-32569	90	39	:	:	PUNCT
ajst-32569	90	40	neural	neural	ADJ
ajst-32569	90	41	circuits	circuit	NOUN
ajst-32569	90	42	,	,	PUNCT
ajst-32569	90	43	endocrine	endocrine	NOUN
ajst-32569	90	44	,	,	PUNCT
ajst-32569	90	45	and	and	CCONJ
ajst-32569	90	46	immune	immune	NOUN
ajst-32569	90	47	.	.	PUNCT
ajst-32569	91	1	long	long	ADJ
ajst-32569	91	2	-	-	PUNCT
ajst-32569	91	3	term	term	NOUN
ajst-32569	91	4	stress	stress	NOUN
ajst-32569	91	5	activates	activate	VERB
ajst-32569	91	6	the	the	DET
ajst-32569	91	7	immune	immune	ADJ
ajst-32569	91	8	system	system	NOUN
ajst-32569	91	9	;	;	PUNCT
ajst-32569	91	10	the	the	DET
ajst-32569	91	11	induced	induce	VERB
ajst-32569	91	12	neuroinflammation	neuroinflammation	NOUN
ajst-32569	91	13	impairs	impair	VERB
ajst-32569	91	14	neuroplasticity	neuroplasticity	NOUN
ajst-32569	91	15	through	through	ADP
ajst-32569	91	16	various	various	ADJ
ajst-32569	91	17	molecular	molecular	ADJ
ajst-32569	91	18	pathways	pathway	NOUN
ajst-32569	91	19	,	,	PUNCT
ajst-32569	91	20	leading	lead	VERB
ajst-32569	91	21	to	to	ADP
ajst-32569	91	22	brain	brain	VERB
ajst-32569	91	23	structural	structural	ADJ
ajst-32569	91	24	abnormalities	abnormality	NOUN
ajst-32569	91	25	and	and	CCONJ
ajst-32569	91	26	neural	neural	ADJ
ajst-32569	91	27	network	network	NOUN
ajst-32569	91	28	dysfunction	dysfunction	NOUN
ajst-32569	91	29	,	,	PUNCT
ajst-32569	91	30	ultimately	ultimately	ADV
ajst-32569	91	31	manifesting	manifest	VERB
ajst-32569	91	32	as	as	ADP
ajst-32569	91	33	depression	depression	NOUN
ajst-32569	91	34	.	.	PUNCT
ajst-32569	92	1	this	this	PRON
ajst-32569	92	2	provides	provide	VERB
ajst-32569	92	3	a	a	DET
ajst-32569	92	4	more	more	ADV
ajst-32569	92	5	comprehensive	comprehensive	ADJ
ajst-32569	92	6	and	and	CCONJ
ajst-32569	92	7	scientific	scientific	ADJ
ajst-32569	92	8	explanation	explanation	NOUN
ajst-32569	92	9	for	for	ADP
ajst-32569	92	10	understanding	understand	VERB
ajst-32569	92	11	the	the	DET
ajst-32569	92	12	chronicity	chronicity	NOUN
ajst-32569	92	13	,	,	PUNCT
ajst-32569	92	14	recurrence	recurrence	NOUN
ajst-32569	92	15	,	,	PUNCT
ajst-32569	92	16	and	and	CCONJ
ajst-32569	92	17	symptom	symptom	NOUN
ajst-32569	92	18	diversity	diversity	NOUN
ajst-32569	92	19	of	of	ADP
ajst-32569	92	20	depression	depression	NOUN
ajst-32569	92	21	.	.	PUNCT
ajst-32569	93	1	despite	despite	SCONJ
ajst-32569	93	2	significant	significant	ADJ
ajst-32569	93	3	progress	progress	NOUN
ajst-32569	93	4	,	,	PUNCT
ajst-32569	93	5	the	the	DET
ajst-32569	93	6	field	field	NOUN
ajst-32569	93	7	still	still	ADV
ajst-32569	93	8	faces	face	VERB
ajst-32569	93	9	many	many	ADJ
ajst-32569	93	10	challenges	challenge	NOUN
ajst-32569	93	11	.	.	PUNCT
ajst-32569	94	1	many	many	ADJ
ajst-32569	94	2	current	current	ADJ
ajst-32569	94	3	findings	finding	NOUN
ajst-32569	94	4	remain	remain	VERB
ajst-32569	94	5	correlational	correlational	ADJ
ajst-32569	94	6	;	;	PUNCT
ajst-32569	94	7	there	there	PRON
ajst-32569	94	8	is	be	VERB
ajst-32569	94	9	a	a	DET
ajst-32569	94	10	need	need	NOUN
ajst-32569	94	11	to	to	PART
ajst-32569	94	12	utilize	utilize	VERB
ajst-32569	94	13	more	more	ADV
ajst-32569	94	14	advanced	advanced	ADJ
ajst-32569	94	15	animal	animal	NOUN
ajst-32569	94	16	models	model	NOUN
ajst-32569	94	17	(	(	PUNCT
ajst-32569	94	18	e.g.	e.g.	ADV
ajst-32569	94	19	,	,	PUNCT
ajst-32569	94	20	optogenetics	optogenetic	NOUN
ajst-32569	94	21	,	,	PUNCT
ajst-32569	94	22	chemogenetics	chemogenetic	NOUN
ajst-32569	94	23	)	)	PUNCT
ajst-32569	94	24	and	and	CCONJ
ajst-32569	94	25	longitudinal	longitudinal	ADJ
ajst-32569	94	26	clinical	clinical	ADJ
ajst-32569	94	27	studies	study	NOUN
ajst-32569	94	28	to	to	PART
ajst-32569	94	29	clarify	clarify	VERB
ajst-32569	94	30	the	the	DET
ajst-32569	94	31	causal	causal	NOUN
ajst-32569	94	32	(	(	PUNCT
ajst-32569	94	33	temporal	temporal	ADJ
ajst-32569	94	34	)	)	PUNCT
ajst-32569	94	35	relationship	relationship	NOUN
ajst-32569	94	36	between	between	ADP
ajst-32569	94	37	these	these	DET
ajst-32569	94	38	biological	biological	ADJ
ajst-32569	94	39	changes	change	NOUN
ajst-32569	94	40	and	and	CCONJ
ajst-32569	94	41	depressive	depressive	ADJ
ajst-32569	94	42	symptoms	symptom	NOUN
ajst-32569	94	43	.	.	PUNCT
ajst-32569	95	1	on	on	ADP
ajst-32569	95	2	the	the	DET
ajst-32569	95	3	other	other	ADJ
ajst-32569	95	4	hand	hand	NOUN
ajst-32569	95	5	,	,	PUNCT
ajst-32569	95	6	we	we	PRON
ajst-32569	95	7	can	can	AUX
ajst-32569	95	8	fully	fully	ADV
ajst-32569	95	9	leverage	leverage	VERB
ajst-32569	95	10	multimodal	multimodal	NOUN
ajst-32569	95	11	data	datum	NOUN
ajst-32569	95	12	fusion	fusion	NOUN
ajst-32569	95	13	(	(	PUNCT
ajst-32569	95	14	imaging	imaging	NOUN
ajst-32569	95	15	,	,	PUNCT
ajst-32569	95	16	blood	blood	NOUN
ajst-32569	95	17	,	,	PUNCT
ajst-32569	95	18	genetics	genetic	NOUN
ajst-32569	95	19	,	,	PUNCT
ajst-32569	95	20	behavior	behavior	NOUN
ajst-32569	95	21	)	)	PUNCT
ajst-32569	95	22	and	and	CCONJ
ajst-32569	95	23	artificial	artificial	ADJ
ajst-32569	95	24	intelligence	intelligence	NOUN
ajst-32569	95	25	/	/	SYM
ajst-32569	95	26	machine	machine	NOUN
ajst-32569	95	27	learning	learn	VERB
ajst-32569	95	28	algorithms	algorithm	NOUN
ajst-32569	95	29	to	to	PART
ajst-32569	95	30	discover	discover	VERB
ajst-32569	95	31	new	new	ADJ
ajst-32569	95	32	,	,	PUNCT
ajst-32569	95	33	more	more	ADV
ajst-32569	95	34	predictive	predictive	ADJ
ajst-32569	95	35	disease	disease	NOUN
ajst-32569	95	36	subtypes	subtype	NOUN
ajst-32569	95	37	in	in	ADP
ajst-32569	95	38	a	a	DET
ajst-32569	95	39	data	data	NOUN
ajst-32569	95	40	-	-	PUNCT
ajst-32569	95	41	driven	drive	VERB
ajst-32569	95	42	manner	manner	NOUN
ajst-32569	95	43	.	.	PUNCT
ajst-32569	96	1	future	future	ADJ
ajst-32569	96	2	research	research	NOUN
ajst-32569	96	3	should	should	AUX
ajst-32569	96	4	also	also	ADV
ajst-32569	96	5	focus	focus	VERB
ajst-32569	96	6	on	on	ADP
ajst-32569	96	7	bridging	bridge	VERB
ajst-32569	96	8	the	the	DET
ajst-32569	96	9	micro	micro	NOUN
ajst-32569	96	10	(	(	PUNCT
ajst-32569	96	11	e.g.	e.g.	ADV
ajst-32569	96	12	,	,	PUNCT
ajst-32569	96	13	specific	specific	ADJ
ajst-32569	96	14	cytokine	cytokine	NOUN
ajst-32569	96	15	signaling	signal	VERB
ajst-32569	96	16	like	like	ADP
ajst-32569	96	17	jak	jak	PROPN
ajst-32569	96	18	-	-	PUNCT
ajst-32569	96	19	stat	stat	PROPN
ajst-32569	96	20	,	,	PUNCT
ajst-32569	96	21	nf	nf	NOUN
ajst-32569	96	22	-	-	PUNCT
ajst-32569	96	23	κb	κb	NOUN
ajst-32569	96	24	)	)	PUNCT
ajst-32569	96	25	and	and	CCONJ
ajst-32569	96	26	macro	macro	ADJ
ajst-32569	96	27	levels	level	NOUN
ajst-32569	96	28	,	,	PUNCT
ajst-32569	96	29	and	and	CCONJ
ajst-32569	96	30	developing	develop	VERB
ajst-32569	96	31	rapid	rapid	ADJ
ajst-32569	96	32	-	-	PUNCT
ajst-32569	96	33	acting	act	VERB
ajst-32569	96	34	anti	anti	ADJ
ajst-32569	96	35	-	-	ADJ
ajst-32569	96	36	inflammatory	inflammatory	ADJ
ajst-32569	96	37	strategies	strategy	NOUN
ajst-32569	96	38	.	.	PUNCT
ajst-32569	97	1	167	167	NUM
ajst-32569	97	2	in	in	ADP
ajst-32569	97	3	conclusion	conclusion	NOUN
ajst-32569	97	4	,	,	PUNCT
ajst-32569	97	5	the	the	DET
ajst-32569	97	6	exploration	exploration	NOUN
ajst-32569	97	7	of	of	ADP
ajst-32569	97	8	the	the	DET
ajst-32569	97	9	neurophysiological	neurophysiological	ADJ
ajst-32569	97	10	mechanisms	mechanism	NOUN
ajst-32569	97	11	of	of	ADP
ajst-32569	97	12	depression	depression	NOUN
ajst-32569	97	13	has	have	AUX
ajst-32569	97	14	entered	enter	VERB
ajst-32569	97	15	a	a	DET
ajst-32569	97	16	new	new	ADJ
ajst-32569	97	17	stage	stage	NOUN
ajst-32569	97	18	full	full	ADJ
ajst-32569	97	19	of	of	ADP
ajst-32569	97	20	vitality	vitality	NOUN
ajst-32569	97	21	and	and	CCONJ
ajst-32569	97	22	hope	hope	NOUN
ajst-32569	97	23	.	.	PUNCT
ajst-32569	98	1	the	the	DET
ajst-32569	98	2	paradigm	paradigm	NOUN
ajst-32569	98	3	shift	shift	NOUN
ajst-32569	98	4	from	from	ADP
ajst-32569	98	5	monoamines	monoamine	NOUN
ajst-32569	98	6	to	to	ADP
ajst-32569	98	7	neuroplasticity	neuroplasticity	NOUN
ajst-32569	98	8	and	and	CCONJ
ajst-32569	98	9	neuroinflammation	neuroinflammation	NOUN
ajst-32569	98	10	has	have	AUX
ajst-32569	98	11	not	not	PART
ajst-32569	98	12	only	only	ADV
ajst-32569	98	13	profoundly	profoundly	ADV
ajst-32569	98	14	renewed	renew	VERB
ajst-32569	98	15	our	our	PRON
ajst-32569	98	16	understanding	understanding	NOUN
ajst-32569	98	17	of	of	ADP
ajst-32569	98	18	the	the	DET
ajst-32569	98	19	disease	disease	NOUN
ajst-32569	98	20	's	's	PART
ajst-32569	98	21	essence	essence	NOUN
ajst-32569	98	22	but	but	CCONJ
ajst-32569	98	23	also	also	ADV
ajst-32569	98	24	opened	open	VERB
ajst-32569	98	25	up	up	ADP
ajst-32569	98	26	broad	broad	ADJ
ajst-32569	98	27	space	space	NOUN
ajst-32569	98	28	for	for	ADP
ajst-32569	98	29	therapeutic	therapeutic	ADJ
ajst-32569	98	30	innovation	innovation	NOUN
ajst-32569	98	31	.	.	PUNCT
ajst-32569	99	1	through	through	ADP
ajst-32569	99	2	continuous	continuous	ADJ
ajst-32569	99	3	basic	basic	ADJ
ajst-32569	99	4	and	and	CCONJ
ajst-32569	99	5	clinical	clinical	ADJ
ajst-32569	99	6	translational	translational	ADJ
ajst-32569	99	7	research	research	NOUN
ajst-32569	99	8	,	,	PUNCT
ajst-32569	99	9	we	we	PRON
ajst-32569	99	10	are	be	AUX
ajst-32569	99	11	expected	expect	VERB
ajst-32569	99	12	to	to	PART
ajst-32569	99	13	eventually	eventually	ADV
ajst-32569	99	14	decipher	decipher	VERB
ajst-32569	99	15	the	the	DET
ajst-32569	99	16	code	code	NOUN
ajst-32569	99	17	of	of	ADP
ajst-32569	99	18	this	this	DET
ajst-32569	99	19	complex	complex	ADJ
ajst-32569	99	20	disease	disease	NOUN
ajst-32569	99	21	and	and	CCONJ
ajst-32569	99	22	bring	bring	VERB
ajst-32569	99	23	more	more	ADV
ajst-32569	99	24	effective	effective	ADJ
ajst-32569	99	25	and	and	CCONJ
ajst-32569	99	26	personalized	personalized	ADJ
ajst-32569	99	27	diagnostic	diagnostic	ADJ
ajst-32569	99	28	and	and	CCONJ
ajst-32569	99	29	treatment	treatment	NOUN
ajst-32569	99	30	options	option	NOUN
ajst-32569	99	31	to	to	ADP
ajst-32569	99	32	millions	million	NOUN
ajst-32569	99	33	of	of	ADP
ajst-32569	99	34	patients	patient	NOUN
ajst-32569	99	35	.	.	PUNCT
ajst-32569	100	1	references	reference	NOUN
ajst-32569	100	2	[	[	X
ajst-32569	100	3	1	1	NUM
ajst-32569	100	4	]	]	PUNCT
ajst-32569	100	5	coppen	coppen	NOUN
ajst-32569	100	6	,	,	PUNCT
ajst-32569	100	7	a.	a.	NOUN
ajst-32569	100	8	(	(	PUNCT
ajst-32569	100	9	1967	1967	NUM
ajst-32569	100	10	)	)	PUNCT
ajst-32569	100	11	.	.	PUNCT
ajst-32569	101	1	the	the	DET
ajst-32569	101	2	biochemistry	biochemistry	NOUN
ajst-32569	101	3	of	of	ADP
ajst-32569	101	4	affective	affective	ADJ
ajst-32569	101	5	disorders	disorder	NOUN
ajst-32569	101	6	.	.	PUNCT
ajst-32569	102	1	british	british	ADJ
ajst-32569	102	2	journal	journal	PROPN
ajst-32569	102	3	of	of	ADP
ajst-32569	102	4	psychiatry	psychiatry	NOUN
ajst-32569	102	5	,	,	PUNCT
ajst-32569	102	6	213(505	213(505	NUM
ajst-32569	102	7	)	)	PUNCT
ajst-32569	102	8	,	,	PUNCT
ajst-32569	102	9	1233–1237	1233–1237	NUM
ajst-32569	102	10	.	.	PUNCT
ajst-32569	103	1	[	[	X
ajst-32569	103	2	2	2	NUM
ajst-32569	103	3	]	]	PUNCT
ajst-32569	103	4	delgado	delgado	NOUN
ajst-32569	103	5	,	,	PUNCT
ajst-32569	103	6	p.	p.	PROPN
ajst-32569	103	7	l.	l.	PROPN
ajst-32569	103	8	,	,	PUNCT
ajst-32569	103	9	charney	charney	PROPN
ajst-32569	103	10	,	,	PUNCT
ajst-32569	103	11	d.	d.	PROPN
ajst-32569	103	12	s.	s.	PROPN
ajst-32569	103	13	,	,	PUNCT
ajst-32569	103	14	price	price	NOUN
ajst-32569	103	15	,	,	PUNCT
ajst-32569	103	16	l.	l.	PROPN
ajst-32569	103	17	h.	h.	PROPN
ajst-32569	103	18	,	,	PUNCT
ajst-32569	103	19	aghajanian	aghajanian	PROPN
ajst-32569	103	20	,	,	PUNCT
ajst-32569	103	21	g.	g.	PROPN
ajst-32569	103	22	k.	k.	PROPN
ajst-32569	103	23	,	,	PUNCT
ajst-32569	103	24	landis	landis	PROPN
ajst-32569	103	25	,	,	PUNCT
ajst-32569	103	26	h.	h.	PROPN
ajst-32569	103	27	,	,	PUNCT
ajst-32569	103	28	&	&	CCONJ
ajst-32569	103	29	heninger	heninger	PROPN
ajst-32569	103	30	,	,	PUNCT
ajst-32569	103	31	g.	g.	PROPN
ajst-32569	103	32	r.	r.	PROPN
ajst-32569	103	33	(	(	PUNCT
ajst-32569	103	34	1990	1990	NUM
ajst-32569	103	35	)	)	PUNCT
ajst-32569	103	36	.	.	PUNCT
ajst-32569	104	1	serotonin	serotonin	VERB
ajst-32569	104	2	and	and	CCONJ
ajst-32569	104	3	the	the	DET
ajst-32569	104	4	neurobiology	neurobiology	NOUN
ajst-32569	104	5	of	of	ADP
ajst-32569	104	6	depression	depression	NOUN
ajst-32569	104	7	.	.	PUNCT
ajst-32569	105	1	effects	effect	NOUN
ajst-32569	105	2	of	of	ADP
ajst-32569	105	3	tryptophan	tryptophan	NOUN
ajst-32569	105	4	depletion	depletion	NOUN
ajst-32569	105	5	in	in	ADP
ajst-32569	105	6	drug	drug	NOUN
ajst-32569	105	7	-	-	PUNCT
ajst-32569	105	8	free	free	ADJ
ajst-32569	105	9	depressed	depressed	ADJ
ajst-32569	105	10	patients	patient	NOUN
ajst-32569	105	11	.	.	PUNCT
ajst-32569	106	1	archives	archive	NOUN
ajst-32569	106	2	of	of	ADP
ajst-32569	106	3	general	general	ADJ
ajst-32569	106	4	psychiatry	psychiatry	NOUN
ajst-32569	106	5	,	,	PUNCT
ajst-32569	106	6	47(5	47(5	NOUN
ajst-32569	106	7	)	)	PUNCT
ajst-32569	106	8	,	,	PUNCT
ajst-32569	106	9	411–418	411–418	NUM
ajst-32569	106	10	.	.	PUNCT
ajst-32569	107	1	[	[	X
ajst-32569	107	2	3	3	NUM
ajst-32569	107	3	]	]	X
ajst-32569	107	4	drevets	drevet	NOUN
ajst-32569	107	5	,	,	PUNCT
ajst-32569	107	6	w.	w.	PROPN
ajst-32569	107	7	c.	c.	PROPN
ajst-32569	107	8	,	,	PUNCT
ajst-32569	107	9	price	price	NOUN
ajst-32569	107	10	,	,	PUNCT
ajst-32569	107	11	j.	j.	PROPN
ajst-32569	107	12	l.	l.	PROPN
ajst-32569	107	13	,	,	PUNCT
ajst-32569	107	14	&	&	CCONJ
ajst-32569	107	15	furey	furey	PROPN
ajst-32569	107	16	,	,	PUNCT
ajst-32569	107	17	m.	m.	NOUN
ajst-32569	107	18	l.	l.	PROPN
ajst-32569	107	19	(	(	PUNCT
ajst-32569	107	20	2008	2008	NUM
ajst-32569	107	21	)	)	PUNCT
ajst-32569	107	22	.	.	PUNCT
ajst-32569	108	1	brain	brain	NOUN
ajst-32569	108	2	structural	structural	ADJ
ajst-32569	108	3	and	and	CCONJ
ajst-32569	108	4	functional	functional	ADJ
ajst-32569	108	5	abnormalities	abnormality	NOUN
ajst-32569	108	6	in	in	ADP
ajst-32569	108	7	mood	mood	NOUN
ajst-32569	108	8	disorders	disorder	NOUN
ajst-32569	108	9	:	:	PUNCT
ajst-32569	108	10	implications	implication	NOUN
ajst-32569	108	11	for	for	ADP
ajst-32569	108	12	neurocircuitry	neurocircuitry	ADJ
ajst-32569	108	13	models	model	NOUN
ajst-32569	108	14	of	of	ADP
ajst-32569	108	15	depression	depression	NOUN
ajst-32569	108	16	.	.	PUNCT
ajst-32569	109	1	brain	brain	NOUN
ajst-32569	109	2	structure	structure	NOUN
ajst-32569	109	3	and	and	CCONJ
ajst-32569	109	4	function	function	NOUN
ajst-32569	109	5	,	,	PUNCT
ajst-32569	109	6	213(1	213(1	NUM
ajst-32569	109	7	-	-	SYM
ajst-32569	109	8	2	2	NUM
ajst-32569	109	9	)	)	PUNCT
ajst-32569	109	10	,	,	PUNCT
ajst-32569	109	11	93–118	93–118	NUM
ajst-32569	109	12	.	.	PUNCT
ajst-32569	110	1	[	[	X
ajst-32569	110	2	4	4	NUM
ajst-32569	110	3	]	]	X
ajst-32569	110	4	mayberg	mayberg	PROPN
ajst-32569	110	5	,	,	PUNCT
ajst-32569	110	6	h.	h.	PROPN
ajst-32569	110	7	s.	s.	PROPN
ajst-32569	110	8	(	(	PUNCT
ajst-32569	110	9	1997	1997	NUM
ajst-32569	110	10	)	)	PUNCT
ajst-32569	110	11	.	.	PUNCT
ajst-32569	111	1	limbic	limbic	ADJ
ajst-32569	111	2	-	-	PUNCT
ajst-32569	111	3	cortical	cortical	ADJ
ajst-32569	111	4	dysregulation	dysregulation	NOUN
ajst-32569	111	5	:	:	PUNCT
ajst-32569	111	6	a	a	DET
ajst-32569	111	7	proposed	propose	VERB
ajst-32569	111	8	model	model	NOUN
ajst-32569	111	9	of	of	ADP
ajst-32569	111	10	depression	depression	NOUN
ajst-32569	111	11	.	.	PUNCT
ajst-32569	112	1	the	the	DET
ajst-32569	112	2	journal	journal	PROPN
ajst-32569	112	3	of	of	ADP
ajst-32569	112	4	neuropsychiatry	neuropsychiatry	NOUN
ajst-32569	112	5	and	and	CCONJ
ajst-32569	112	6	clinical	clinical	ADJ
ajst-32569	112	7	neurosciences	neuroscience	NOUN
ajst-32569	112	8	,	,	PUNCT
ajst-32569	112	9	9(3	9(3	NUM
ajst-32569	112	10	)	)	PUNCT
ajst-32569	112	11	,	,	PUNCT
ajst-32569	112	12	471–481	471–481	NUM
ajst-32569	112	13	.	.	PUNCT
ajst-32569	113	1	[	[	X
ajst-32569	113	2	5	5	NUM
ajst-32569	113	3	]	]	X
ajst-32569	113	4	miller	miller	PROPN
ajst-32569	113	5	,	,	PUNCT
ajst-32569	113	6	a.	a.	PROPN
ajst-32569	113	7	h.	h.	PROPN
ajst-32569	113	8	,	,	PUNCT
ajst-32569	113	9	&	&	CCONJ
ajst-32569	113	10	raison	raison	PROPN
ajst-32569	113	11	,	,	PUNCT
ajst-32569	113	12	c.	c.	PROPN
ajst-32569	113	13	l.	l.	PROPN
ajst-32569	113	14	(	(	PUNCT
ajst-32569	113	15	2016	2016	NUM
ajst-32569	113	16	)	)	PUNCT
ajst-32569	113	17	.	.	PUNCT
ajst-32569	114	1	the	the	DET
ajst-32569	114	2	role	role	NOUN
ajst-32569	114	3	of	of	ADP
ajst-32569	114	4	inflammation	inflammation	NOUN
ajst-32569	114	5	in	in	ADP
ajst-32569	114	6	depression	depression	NOUN
ajst-32569	114	7	:	:	PUNCT
ajst-32569	114	8	from	from	ADP
ajst-32569	114	9	evolutionary	evolutionary	ADJ
ajst-32569	114	10	imperative	imperative	NOUN
ajst-32569	114	11	to	to	ADP
ajst-32569	114	12	modern	modern	ADJ
ajst-32569	114	13	treatment	treatment	NOUN
ajst-32569	114	14	target	target	NOUN
ajst-32569	114	15	.	.	PUNCT
ajst-32569	115	1	nature	nature	NOUN
ajst-32569	115	2	reviews	review	VERB
ajst-32569	115	3	immunology	immunology	NOUN
ajst-32569	115	4	,	,	PUNCT
ajst-32569	115	5	16(1	16(1	NUM
ajst-32569	115	6	)	)	PUNCT
ajst-32569	115	7	,	,	PUNCT
ajst-32569	115	8	22–34	22–34	NUM
ajst-32569	115	9	.	.	PUNCT
ajst-32569	116	1	[	[	X
ajst-32569	116	2	6	6	NUM
ajst-32569	116	3	]	]	PUNCT
ajst-32569	116	4	schildkraut	schildkraut	NOUN
ajst-32569	116	5	,	,	PUNCT
ajst-32569	116	6	j.	j.	PROPN
ajst-32569	116	7	j.	j.	PROPN
ajst-32569	116	8	(	(	PUNCT
ajst-32569	116	9	1965	1965	NUM
ajst-32569	116	10	)	)	PUNCT
ajst-32569	116	11	.	.	PUNCT
ajst-32569	117	1	the	the	DET
ajst-32569	117	2	catecholamine	catecholamine	NOUN
ajst-32569	117	3	hypothesis	hypothesis	NOUN
ajst-32569	117	4	of	of	ADP
ajst-32569	117	5	affective	affective	ADJ
ajst-32569	117	6	disorders	disorder	NOUN
ajst-32569	117	7	:	:	PUNCT
ajst-32569	117	8	a	a	DET
ajst-32569	117	9	review	review	NOUN
ajst-32569	117	10	of	of	ADP
ajst-32569	117	11	supporting	support	VERB
ajst-32569	117	12	evidence	evidence	NOUN
ajst-32569	117	13	.	.	PUNCT
ajst-32569	118	1	american	american	ADJ
ajst-32569	118	2	journal	journal	PROPN
ajst-32569	118	3	of	of	ADP
ajst-32569	118	4	psychiatry	psychiatry	NOUN
ajst-32569	118	5	,	,	PUNCT
ajst-32569	118	6	122(5	122(5	NUM
ajst-32569	118	7	)	)	PUNCT
ajst-32569	118	8	,	,	PUNCT
ajst-32569	118	9	509–522	509–522	NUM
ajst-32569	118	10	.	.	PUNCT
ajst-32569	119	1	[	[	X
ajst-32569	119	2	7	7	X
ajst-32569	119	3	]	]	PUNCT
ajst-32569	119	4	world	world	NOUN
ajst-32569	119	5	health	health	NOUN
ajst-32569	119	6	organization	organization	NOUN
ajst-32569	119	7	.	.	PUNCT
ajst-32569	120	1	(	(	PUNCT
ajst-32569	120	2	2017	2017	NUM
ajst-32569	120	3	)	)	PUNCT
ajst-32569	120	4	.	.	PUNCT
ajst-32569	121	1	depression	depression	NOUN
ajst-32569	121	2	and	and	CCONJ
ajst-32569	121	3	other	other	ADJ
ajst-32569	121	4	common	common	ADJ
ajst-32569	121	5	mental	mental	ADJ
ajst-32569	121	6	disorders	disorder	NOUN
ajst-32569	121	7	:	:	PUNCT
ajst-32569	121	8	global	global	ADJ
ajst-32569	121	9	health	health	NOUN
ajst-32569	121	10	estimates	estimate	NOUN
ajst-32569	121	11	.	.	PUNCT
ajst-32569	122	1	geneva	geneva	PROPN
ajst-32569	122	2	:	:	PUNCT
ajst-32569	122	3	world	world	PROPN
ajst-32569	122	4	health	health	PROPN
ajst-32569	122	5	organization	organization	NOUN
ajst-32569	122	6	.	.	PUNCT
ajst-32569	123	1	[	[	X
ajst-32569	123	2	8	8	NUM
ajst-32569	123	3	]	]	X
ajst-32569	123	4	hajima	hajima	PROPN
ajst-32569	123	5	,	,	PUNCT
ajst-32569	123	6	s.	s.	PROPN
ajst-32569	123	7	v.	v.	PROPN
ajst-32569	123	8	,	,	PUNCT
ajst-32569	123	9	van	van	PROPN
ajst-32569	123	10	haren	haren	PROPN
ajst-32569	123	11	,	,	PUNCT
ajst-32569	123	12	n.	n.	PROPN
ajst-32569	123	13	e.	e.	PROPN
ajst-32569	123	14	m.	m.	PROPN
ajst-32569	123	15	,	,	PUNCT
ajst-32569	123	16	cahn	cahn	PROPN
ajst-32569	123	17	,	,	PUNCT
ajst-32569	123	18	w.	w.	PROPN
ajst-32569	123	19	,	,	PUNCT
ajst-32569	123	20	koolschijn	koolschijn	PROPN
ajst-32569	123	21	,	,	PUNCT
ajst-32569	123	22	p.	p.	PROPN
ajst-32569	123	23	c.	c.	PROPN
ajst-32569	123	24	m.	m.	PROPN
ajst-32569	123	25	p.	p.	PROPN
ajst-32569	123	26	,	,	PUNCT
ajst-32569	123	27	hulshoff	hulshoff	NOUN
ajst-32569	123	28	pol	pol	PROPN
ajst-32569	123	29	,	,	PUNCT
ajst-32569	123	30	h.	h.	PROPN
ajst-32569	123	31	e.	e.	PROPN
ajst-32569	123	32	,	,	PUNCT
ajst-32569	123	33	&	&	CCONJ
ajst-32569	123	34	kahn	kahn	PROPN
ajst-32569	123	35	,	,	PUNCT
ajst-32569	123	36	r.	r.	PROPN
ajst-32569	123	37	s.	s.	PROPN
ajst-32569	123	38	(	(	PUNCT
ajst-32569	123	39	2013	2013	NUM
ajst-32569	123	40	)	)	PUNCT
ajst-32569	123	41	.	.	PUNCT
ajst-32569	124	1	brain	brain	NOUN
ajst-32569	124	2	volumes	volume	NOUN
ajst-32569	124	3	in	in	ADP
ajst-32569	124	4	schizophrenia	schizophrenia	NOUN
ajst-32569	124	5	:	:	PUNCT
ajst-32569	124	6	a	a	DET
ajst-32569	124	7	meta	meta	ADJ
ajst-32569	124	8	-	-	PUNCT
ajst-32569	124	9	analysis	analysis	NOUN
ajst-32569	124	10	in	in	ADP
ajst-32569	124	11	over	over	ADP
ajst-32569	124	12	18	18	NUM
ajst-32569	124	13	000	000	NUM
ajst-32569	124	14	subjects	subject	NOUN
ajst-32569	124	15	.	.	PUNCT
ajst-32569	125	1	schizophrenia	schizophrenia	PROPN
ajst-32569	125	2	bulletin	bulletin	NOUN
ajst-32569	125	3	,	,	PUNCT
ajst-32569	125	4	39(5	39(5	NUM
ajst-32569	125	5	)	)	PUNCT
ajst-32569	125	6	,	,	PUNCT
ajst-32569	125	7	1129–1138	1129–1138	NUM
ajst-32569	125	8	.	.	PUNCT
ajst-32569	126	1	[	[	X
ajst-32569	126	2	9	9	NUM
ajst-32569	126	3	]	]	X
ajst-32569	126	4	nguyen	nguyen	NOUN
ajst-32569	126	5	,	,	PUNCT
ajst-32569	126	6	t.-v	t.-v	PROPN
ajst-32569	126	7	.	.	PUNCT
ajst-32569	126	8	,	,	PUNCT
ajst-32569	126	9	wu	wu	PROPN
ajst-32569	126	10	,	,	PUNCT
ajst-32569	126	11	m.	m.	NOUN
ajst-32569	126	12	,	,	PUNCT
ajst-32569	126	13	vickers	vickers	PROPN
ajst-32569	126	14	,	,	PUNCT
ajst-32569	126	15	k.	k.	PROPN
ajst-32569	126	16	l.	l.	PROPN
ajst-32569	126	17	,	,	PUNCT
ajst-32569	126	18	&	&	CCONJ
ajst-32569	126	19	matuskey	matuskey	PROPN
ajst-32569	126	20	,	,	PUNCT
ajst-32569	126	21	d.	d.	PROPN
ajst-32569	126	22	(	(	PUNCT
ajst-32569	126	23	2021	2021	NUM
ajst-32569	126	24	)	)	PUNCT
ajst-32569	126	25	.	.	PUNCT
ajst-32569	127	1	neurobiological	neurobiological	ADJ
ajst-32569	127	2	and	and	CCONJ
ajst-32569	127	3	neuropsychiatric	neuropsychiatric	ADJ
ajst-32569	127	4	correlates	correlate	NOUN
ajst-32569	127	5	of	of	ADP
ajst-32569	127	6	brain	brain	NOUN
ajst-32569	127	7	reward	reward	NOUN
ajst-32569	127	8	circuits	circuit	NOUN
ajst-32569	127	9	in	in	ADP
ajst-32569	127	10	depression	depression	NOUN
ajst-32569	127	11	:	:	PUNCT
ajst-32569	127	12	a	a	DET
ajst-32569	127	13	multimodal	multimodal	ADJ
ajst-32569	127	14	imaging	imaging	NOUN
ajst-32569	127	15	review	review	NOUN
ajst-32569	127	16	.	.	PUNCT
ajst-32569	128	1	neuroscience	neuroscience	PROPN
ajst-32569	128	2	&	&	CCONJ
ajst-32569	128	3	biobehavioral	biobehavioral	ADJ
ajst-32569	128	4	reviews	review	NOUN
ajst-32569	128	5	,	,	PUNCT
ajst-32569	128	6	131	131	NUM
ajst-32569	128	7	,	,	PUNCT
ajst-32569	128	8	117–133	117–133	NUM
ajst-32569	128	9	.	.	PUNCT
ajst-32569	129	1	[	[	X
ajst-32569	129	2	10	10	NUM
ajst-32569	129	3	]	]	X
ajst-32569	129	4	ramirez	ramirez	NOUN
ajst-32569	129	5	-	-	PUNCT
ajst-32569	129	6	mahaluf	mahaluf	PROPN
ajst-32569	129	7	,	,	PUNCT
ajst-32569	129	8	j.	j.	PROPN
ajst-32569	129	9	p.	p.	PROPN
ajst-32569	129	10	,	,	PUNCT
ajst-32569	129	11	rojas	rojas	PROPN
ajst-32569	129	12	,	,	PUNCT
ajst-32569	129	13	s.	s.	PROPN
ajst-32569	129	14	,	,	PUNCT
ajst-32569	129	15	mena	mena	PROPN
ajst-32569	129	16	,	,	PUNCT
ajst-32569	129	17	c.	c.	PROPN
ajst-32569	129	18	,	,	PUNCT
ajst-32569	129	19	tepper	tepper	PROPN
ajst-32569	129	20	,	,	PUNCT
ajst-32569	129	21	á	á	PROPN
ajst-32569	129	22	.	.	PROPN
ajst-32569	129	23	,	,	PUNCT
ajst-32569	129	24	&	&	CCONJ
ajst-32569	129	25	crossley	crossley	PROPN
ajst-32569	129	26	,	,	PUNCT
ajst-32569	129	27	n.	n.	NOUN
ajst-32569	129	28	a.	a.	NOUN
ajst-32569	129	29	(	(	PUNCT
ajst-32569	129	30	2020	2020	NUM
ajst-32569	129	31	)	)	PUNCT
ajst-32569	129	32	.	.	PUNCT
ajst-32569	130	1	the	the	DET
ajst-32569	130	2	role	role	NOUN
ajst-32569	130	3	of	of	ADP
ajst-32569	130	4	the	the	DET
ajst-32569	130	5	subgenual	subgenual	ADJ
ajst-32569	130	6	anterior	anterior	ADJ
ajst-32569	130	7	cingulate	cingulate	NOUN
ajst-32569	130	8	cortex	cortex	NOUN
ajst-32569	130	9	in	in	ADP
ajst-32569	130	10	dorsolateral	dorsolateral	ADJ
ajst-32569	130	11	prefrontal	prefrontal	ADJ
ajst-32569	130	12	cortex	cortex	NOUN
ajst-32569	130	13	activation	activation	NOUN
ajst-32569	130	14	during	during	ADP
ajst-32569	130	15	emotional	emotional	ADJ
ajst-32569	130	16	working	working	NOUN
ajst-32569	130	17	memory	memory	NOUN
ajst-32569	130	18	.	.	PUNCT
ajst-32569	131	1	neuroimage	neuroimage	NOUN
ajst-32569	131	2	,	,	PUNCT
ajst-32569	131	3	220	220	NUM
ajst-32569	131	4	,	,	PUNCT
ajst-32569	131	5	117100	117100	NUM
ajst-32569	131	6	.	.	PUNCT
ajst-32569	132	1	[	[	X
ajst-32569	132	2	11	11	NUM
ajst-32569	132	3	]	]	X
ajst-32569	132	4	shatte	shatte	NOUN
ajst-32569	132	5	,	,	PUNCT
ajst-32569	132	6	a.	a.	PROPN
ajst-32569	132	7	b.	b.	PROPN
ajst-32569	132	8	r.	r.	PROPN
ajst-32569	132	9	,	,	PUNCT
ajst-32569	132	10	hutchinson	hutchinson	PROPN
ajst-32569	132	11	,	,	PUNCT
ajst-32569	132	12	d.	d.	PROPN
ajst-32569	132	13	m.	m.	PROPN
ajst-32569	132	14	,	,	PUNCT
ajst-32569	132	15	&	&	CCONJ
ajst-32569	132	16	teague	teague	PROPN
ajst-32569	132	17	,	,	PUNCT
ajst-32569	132	18	s.	s.	PROPN
ajst-32569	132	19	j.	j.	PROPN
ajst-32569	132	20	(	(	PUNCT
ajst-32569	132	21	2019	2019	NUM
ajst-32569	132	22	)	)	PUNCT
ajst-32569	132	23	.	.	PUNCT
ajst-32569	133	1	machine	machine	NOUN
ajst-32569	133	2	learning	learn	VERB
ajst-32569	133	3	in	in	ADP
ajst-32569	133	4	mental	mental	ADJ
ajst-32569	133	5	health	health	NOUN
ajst-32569	133	6	:	:	PUNCT
ajst-32569	133	7	a	a	DET
ajst-32569	133	8	scoping	scope	VERB
ajst-32569	133	9	review	review	NOUN
ajst-32569	133	10	of	of	ADP
ajst-32569	133	11	methods	method	NOUN
ajst-32569	133	12	and	and	CCONJ
ajst-32569	133	13	applications	application	NOUN
ajst-32569	133	14	.	.	PUNCT
ajst-32569	134	1	psychological	psychological	ADJ
ajst-32569	134	2	medicine	medicine	NOUN
ajst-32569	134	3	,	,	PUNCT
ajst-32569	134	4	49(9	49(9	NUM
ajst-32569	134	5	)	)	PUNCT
ajst-32569	134	6	,	,	PUNCT
ajst-32569	134	7	1426–1448	1426–1448	NUM
ajst-32569	134	8	.	.	PUNCT
ajst-32569	135	1	[	[	X
ajst-32569	135	2	12	12	NUM
ajst-32569	135	3	]	]	X
ajst-32569	135	4	tendolkar	tendolkar	NOUN
ajst-32569	135	5	,	,	PUNCT
ajst-32569	135	6	i.	i.	PROPN
ajst-32569	135	7	,	,	PUNCT
ajst-32569	135	8	van	van	PROPN
ajst-32569	135	9	beek	beek	PROPN
ajst-32569	135	10	,	,	PUNCT
ajst-32569	135	11	m.	m.	NOUN
ajst-32569	135	12	,	,	PUNCT
ajst-32569	135	13	van	van	PROPN
ajst-32569	135	14	oostrom	oostrom	PROPN
ajst-32569	135	15	,	,	PUNCT
ajst-32569	135	16	i.	i.	PROPN
ajst-32569	135	17	,	,	PUNCT
ajst-32569	135	18	mulder	mulder	NOUN
ajst-32569	135	19	,	,	PUNCT
ajst-32569	135	20	m.	m.	NOUN
ajst-32569	135	21	,	,	PUNCT
ajst-32569	135	22	janzing	janzing	NOUN
ajst-32569	135	23	,	,	PUNCT
ajst-32569	135	24	j.	j.	PROPN
ajst-32569	135	25	,	,	PUNCT
ajst-32569	135	26	voshaar	voshaar	NOUN
ajst-32569	135	27	,	,	PUNCT
ajst-32569	135	28	r.	r.	PROPN
ajst-32569	135	29	o.	o.	PROPN
ajst-32569	135	30	,	,	PUNCT
ajst-32569	135	31	&	&	CCONJ
ajst-32569	135	32	van	van	PROPN
ajst-32569	135	33	eijndhoven	eijndhoven	PROPN
ajst-32569	135	34	,	,	PUNCT
ajst-32569	135	35	p.	p.	NOUN
ajst-32569	135	36	(	(	PUNCT
ajst-32569	135	37	2013	2013	NUM
ajst-32569	135	38	)	)	PUNCT
ajst-32569	135	39	.	.	PUNCT
ajst-32569	136	1	electroconvulsive	electroconvulsive	ADJ
ajst-32569	136	2	therapy	therapy	NOUN
ajst-32569	136	3	increases	increase	VERB
ajst-32569	136	4	hippocampal	hippocampal	ADJ
ajst-32569	136	5	and	and	CCONJ
ajst-32569	136	6	amygdala	amygdala	NOUN
ajst-32569	136	7	volume	volume	NOUN
ajst-32569	136	8	in	in	ADP
ajst-32569	136	9	major	major	ADJ
ajst-32569	136	10	depressive	depressive	ADJ
ajst-32569	136	11	disorder	disorder	NOUN
ajst-32569	136	12	:	:	PUNCT
ajst-32569	136	13	a	a	DET
ajst-32569	136	14	longitudinal	longitudinal	ADJ
ajst-32569	136	15	meta	meta	NOUN
ajst-32569	136	16	-	-	PUNCT
ajst-32569	136	17	analysis	analysis	NOUN
ajst-32569	136	18	.	.	PUNCT
ajst-32569	137	1	psychiatry	psychiatry	NOUN
ajst-32569	137	2	research	research	NOUN
ajst-32569	137	3	:	:	PUNCT
ajst-32569	137	4	neuroimaging	neuroimaging	NOUN
ajst-32569	137	5	,	,	PUNCT
ajst-32569	137	6	214(3	214(3	NUM
ajst-32569	137	7	)	)	PUNCT
ajst-32569	137	8	,	,	PUNCT
ajst-32569	137	9	197–203	197–203	NUM
ajst-32569	137	10	.	.	PUNCT
ajst-32569	138	1	[	[	X
ajst-32569	138	2	13	13	NUM
ajst-32569	138	3	]	]	X
ajst-32569	138	4	dantzer	dantzer	NOUN
ajst-32569	138	5	,	,	PUNCT
ajst-32569	138	6	r.	r.	PROPN
ajst-32569	138	7	,	,	PUNCT
ajst-32569	138	8	o'connor	o'connor	PROPN
ajst-32569	138	9	,	,	PUNCT
ajst-32569	138	10	j.	j.	PROPN
ajst-32569	138	11	c.	c.	PROPN
ajst-32569	138	12	,	,	PUNCT
ajst-32569	138	13	lawson	lawson	PROPN
ajst-32569	138	14	,	,	PUNCT
ajst-32569	138	15	m.	m.	NOUN
ajst-32569	138	16	a.	a.	PROPN
ajst-32569	138	17	,	,	PUNCT
ajst-32569	138	18	&	&	CCONJ
ajst-32569	138	19	kelley	kelley	PROPN
ajst-32569	138	20	,	,	PUNCT
ajst-32569	138	21	k.	k.	PROPN
ajst-32569	138	22	w.	w.	PROPN
ajst-32569	138	23	(	(	PUNCT
ajst-32569	138	24	2011	2011	NUM
ajst-32569	138	25	)	)	PUNCT
ajst-32569	138	26	.	.	PUNCT
ajst-32569	139	1	inflammation	inflammation	NOUN
ajst-32569	139	2	-	-	PUNCT
ajst-32569	139	3	associated	associate	VERB
ajst-32569	139	4	depression	depression	NOUN
ajst-32569	139	5	:	:	PUNCT
ajst-32569	139	6	from	from	AUX
ajst-32569	139	7	serotonin	serotonin	VERB
ajst-32569	139	8	to	to	ADP
ajst-32569	139	9	kynurenine	kynurenine	PROPN
ajst-32569	139	10	.	.	PUNCT
ajst-32569	140	1	psychoneuroendocrinology	psychoneuroendocrinology	NOUN
ajst-32569	140	2	,	,	PUNCT
ajst-32569	140	3	36(3	36(3	NUM
ajst-32569	140	4	)	)	PUNCT
ajst-32569	140	5	,	,	PUNCT
ajst-32569	140	6	426–436	426–436	NUM
ajst-32569	140	7	.	.	PUNCT
ajst-32569	141	1	[	[	X
ajst-32569	141	2	14	14	NUM
ajst-32569	141	3	]	]	SYM
ajst-32569	141	4	felger	felger	NOUN
ajst-32569	141	5	,	,	PUNCT
ajst-32569	141	6	j.	j.	PROPN
ajst-32569	141	7	c.	c.	PROPN
ajst-32569	141	8	,	,	PUNCT
ajst-32569	141	9	li	li	PROPN
ajst-32569	141	10	,	,	PUNCT
ajst-32569	141	11	z.	z.	PROPN
ajst-32569	141	12	,	,	PUNCT
ajst-32569	141	13	haroon	haroon	PROPN
ajst-32569	141	14	,	,	PUNCT
ajst-32569	141	15	e.	e.	PROPN
ajst-32569	141	16	,	,	PUNCT
ajst-32569	141	17	woolwine	woolwine	PROPN
ajst-32569	141	18	,	,	PUNCT
ajst-32569	141	19	b.	b.	PROPN
ajst-32569	141	20	j.	j.	PROPN
ajst-32569	141	21	,	,	PUNCT
ajst-32569	141	22	jung	jung	PROPN
ajst-32569	141	23	,	,	PUNCT
ajst-32569	141	24	m.	m.	NOUN
ajst-32569	141	25	y.	y.	PROPN
ajst-32569	141	26	,	,	PUNCT
ajst-32569	141	27	hu	hu	PROPN
ajst-32569	141	28	,	,	PUNCT
ajst-32569	141	29	x.	x.	NOUN
ajst-32569	141	30	,	,	PUNCT
ajst-32569	141	31	&	&	CCONJ
ajst-32569	141	32	miller	miller	PROPN
ajst-32569	141	33	,	,	PUNCT
ajst-32569	141	34	a.	a.	PROPN
ajst-32569	141	35	h.	h.	PROPN
ajst-32569	141	36	(	(	PUNCT
ajst-32569	141	37	2016	2016	NUM
ajst-32569	141	38	)	)	PUNCT
ajst-32569	141	39	.	.	PUNCT
ajst-32569	142	1	inflammation	inflammation	NOUN
ajst-32569	142	2	is	be	AUX
ajst-32569	142	3	associated	associate	VERB
ajst-32569	142	4	with	with	ADP
ajst-32569	142	5	decreased	decrease	VERB
ajst-32569	142	6	functional	functional	ADJ
ajst-32569	142	7	connectivity	connectivity	NOUN
ajst-32569	142	8	within	within	ADP
ajst-32569	142	9	corticostriatal	corticostriatal	ADJ
ajst-32569	142	10	reward	reward	NOUN
ajst-32569	142	11	circuitry	circuitry	NOUN
ajst-32569	142	12	in	in	ADP
ajst-32569	142	13	depression	depression	NOUN
ajst-32569	142	14	.	.	PUNCT
ajst-32569	143	1	molecular	molecular	ADJ
ajst-32569	143	2	psychiatry	psychiatry	NOUN
ajst-32569	143	3	,	,	PUNCT
ajst-32569	143	4	21(10	21(10	NUM
ajst-32569	143	5	)	)	PUNCT
ajst-32569	143	6	,	,	PUNCT
ajst-32569	143	7	1358–1365	1358–1365	NUM
ajst-32569	143	8	.	.	PUNCT
ajst-32569	144	1	[	[	X
ajst-32569	144	2	15	15	NUM
ajst-32569	144	3	]	]	X
ajst-32569	144	4	haapakoski	haapakoski	PROPN
ajst-32569	144	5	,	,	PUNCT
ajst-32569	144	6	r.	r.	PROPN
ajst-32569	144	7	,	,	PUNCT
ajst-32569	144	8	mathieu	mathieu	PROPN
ajst-32569	144	9	,	,	PUNCT
ajst-32569	144	10	j.	j.	PROPN
ajst-32569	144	11	,	,	PUNCT
ajst-32569	144	12	ebmeier	ebmeier	NOUN
ajst-32569	144	13	,	,	PUNCT
ajst-32569	144	14	k.	k.	PROPN
ajst-32569	144	15	p.	p.	PROPN
ajst-32569	144	16	,	,	PUNCT
ajst-32569	144	17	alenius	alenius	PROPN
ajst-32569	144	18	,	,	PUNCT
ajst-32569	144	19	h.	h.	PROPN
ajst-32569	144	20	,	,	PUNCT
ajst-32569	144	21	&	&	CCONJ
ajst-32569	144	22	kivimäki	kivimäki	PROPN
ajst-32569	144	23	,	,	PUNCT
ajst-32569	144	24	m.	m.	NOUN
ajst-32569	144	25	(	(	PUNCT
ajst-32569	144	26	2015	2015	NUM
ajst-32569	144	27	)	)	PUNCT
ajst-32569	144	28	.	.	PUNCT
ajst-32569	145	1	cumulative	cumulative	ADJ
ajst-32569	145	2	metaanalysis	metaanalysis	NOUN
ajst-32569	145	3	of	of	ADP
ajst-32569	145	4	interleukins	interleukin	NOUN
ajst-32569	145	5	6	6	NUM
ajst-32569	145	6	and	and	CCONJ
ajst-32569	145	7	1β	1β	NUM
ajst-32569	145	8	,	,	PUNCT
ajst-32569	145	9	tumour	tumour	NOUN
ajst-32569	145	10	necrosis	necrosis	NOUN
ajst-32569	145	11	factor	factor	NOUN
ajst-32569	145	12	α	α	NOUN
ajst-32569	145	13	and	and	CCONJ
ajst-32569	145	14	c	c	NOUN
ajst-32569	145	15	-	-	PUNCT
ajst-32569	145	16	reactive	reactive	ADJ
ajst-32569	145	17	protein	protein	NOUN
ajst-32569	145	18	in	in	ADP
ajst-32569	145	19	depression	depression	NOUN
ajst-32569	145	20	.	.	PUNCT
ajst-32569	146	1	brain	brain	NOUN
ajst-32569	146	2	,	,	PUNCT
ajst-32569	146	3	behavior	behavior	NOUN
ajst-32569	146	4	,	,	PUNCT
ajst-32569	146	5	and	and	CCONJ
ajst-32569	146	6	immunity	immunity	NOUN
ajst-32569	146	7	,	,	PUNCT
ajst-32569	146	8	49	49	NUM
ajst-32569	146	9	,	,	PUNCT
ajst-32569	146	10	206–215	206–215	NUM
ajst-32569	146	11	.	.	PUNCT
ajst-32569	147	1	[	[	X
ajst-32569	147	2	16	16	NUM
ajst-32569	147	3	]	]	X
ajst-32569	147	4	holmes	holme	NOUN
ajst-32569	147	5	,	,	PUNCT
ajst-32569	147	6	s.	s.	PROPN
ajst-32569	147	7	e.	e.	PROPN
ajst-32569	147	8	,	,	PUNCT
ajst-32569	147	9	hinz	hinz	PROPN
ajst-32569	147	10	,	,	PUNCT
ajst-32569	147	11	r.	r.	PROPN
ajst-32569	147	12	,	,	PUNCT
ajst-32569	147	13	conen	conen	PROPN
ajst-32569	147	14	,	,	PUNCT
ajst-32569	147	15	s.	s.	PROPN
ajst-32569	147	16	,	,	PUNCT
ajst-32569	147	17	gregory	gregory	PROPN
ajst-32569	147	18	,	,	PUNCT
ajst-32569	147	19	c.	c.	PROPN
ajst-32569	147	20	j.	j.	PROPN
ajst-32569	147	21	,	,	PUNCT
ajst-32569	147	22	matthews	matthews	PROPN
ajst-32569	147	23	,	,	PUNCT
ajst-32569	147	24	j.	j.	PROPN
ajst-32569	147	25	c.	c.	PROPN
ajst-32569	147	26	,	,	PUNCT
ajst-32569	147	27	anton	anton	NOUN
ajst-32569	147	28	-	-	PUNCT
ajst-32569	147	29	rodriguez	rodriguez	PROPN
ajst-32569	147	30	,	,	PUNCT
ajst-32569	147	31	j.	j.	PROPN
ajst-32569	147	32	m.	m.	PROPN
ajst-32569	147	33	,	,	PUNCT
ajst-32569	147	34	...	...	PUNCT
ajst-32569	147	35	&	&	CCONJ
ajst-32569	147	36	talbot	talbot	PROPN
ajst-32569	147	37	,	,	PUNCT
ajst-32569	147	38	p.	p.	PROPN
ajst-32569	147	39	s.	s.	PROPN
ajst-32569	147	40	(	(	PUNCT
ajst-32569	147	41	2018	2018	NUM
ajst-32569	147	42	)	)	PUNCT
ajst-32569	147	43	.	.	PUNCT
ajst-32569	148	1	elevated	elevated	ADJ
ajst-32569	148	2	translocator	translocator	NOUN
ajst-32569	148	3	protein	protein	NOUN
ajst-32569	148	4	in	in	ADP
ajst-32569	148	5	anterior	anterior	ADJ
ajst-32569	148	6	cingulate	cingulate	NOUN
ajst-32569	148	7	in	in	ADP
ajst-32569	148	8	major	major	ADJ
ajst-32569	148	9	depression	depression	NOUN
ajst-32569	148	10	and	and	CCONJ
ajst-32569	148	11	a	a	DET
ajst-32569	148	12	role	role	NOUN
ajst-32569	148	13	for	for	ADP
ajst-32569	148	14	inflammation	inflammation	NOUN
ajst-32569	148	15	in	in	ADP
ajst-32569	148	16	suicidal	suicidal	ADJ
ajst-32569	148	17	thinking	thinking	NOUN
ajst-32569	148	18	:	:	PUNCT
ajst-32569	148	19	a	a	DET
ajst-32569	148	20	positron	positron	NOUN
ajst-32569	148	21	emission	emission	NOUN
ajst-32569	148	22	tomography	tomography	NOUN
ajst-32569	148	23	study	study	NOUN
ajst-32569	148	24	.	.	PUNCT
ajst-32569	149	1	biological	biological	ADJ
ajst-32569	149	2	psychiatry	psychiatry	NOUN
ajst-32569	149	3	,	,	PUNCT
ajst-32569	149	4	83(1	83(1	PROPN
ajst-32569	149	5	)	)	PUNCT
ajst-32569	149	6	,	,	PUNCT
ajst-32569	149	7	61–69	61–69	NUM
ajst-32569	149	8	.	.	PUNCT
ajst-32569	149	9	168	168	NUM
ajst-32569	150	1	[	[	X
ajst-32569	150	2	17	17	NUM
ajst-32569	150	3	]	]	X
ajst-32569	150	4	köhler	köhler	PROPN
ajst-32569	150	5	-	-	PUNCT
ajst-32569	150	6	forsberg	forsberg	PROPN
ajst-32569	150	7	,	,	PUNCT
ajst-32569	150	8	o.	o.	PROPN
ajst-32569	150	9	,	,	PUNCT
ajst-32569	150	10	n	n	PRON
ajst-32569	150	11	lydholm	lydholm	NOUN
ajst-32569	150	12	,	,	PUNCT
ajst-32569	150	13	c.	c.	PROPN
ajst-32569	150	14	,	,	PUNCT
ajst-32569	150	15	hjorthøj	hjorthøj	PROPN
ajst-32569	150	16	,	,	PUNCT
ajst-32569	150	17	c.	c.	PROPN
ajst-32569	150	18	,	,	PUNCT
ajst-32569	150	19	nordentoft	nordentoft	PROPN
ajst-32569	150	20	,	,	PUNCT
ajst-32569	150	21	m.	m.	NOUN
ajst-32569	150	22	,	,	PUNCT
ajst-32569	150	23	mors	mor	NOUN
ajst-32569	150	24	,	,	PUNCT
ajst-32569	150	25	o.	o.	PROPN
ajst-32569	150	26	,	,	PUNCT
ajst-32569	150	27	&	&	CCONJ
ajst-32569	150	28	benros	benros	PROPN
ajst-32569	150	29	,	,	PUNCT
ajst-32569	150	30	m.	m.	PROPN
ajst-32569	150	31	e.	e.	PROPN
ajst-32569	150	32	(	(	PUNCT
ajst-32569	150	33	2019	2019	NUM
ajst-32569	150	34	)	)	PUNCT
ajst-32569	150	35	.	.	PUNCT
ajst-32569	151	1	efficacy	efficacy	NOUN
ajst-32569	151	2	of	of	ADP
ajst-32569	151	3	anti	anti	ADJ
ajst-32569	151	4	-	-	ADJ
ajst-32569	151	5	inflammatory	inflammatory	ADJ
ajst-32569	151	6	treatment	treatment	NOUN
ajst-32569	151	7	on	on	ADP
ajst-32569	151	8	major	major	ADJ
ajst-32569	151	9	depressive	depressive	ADJ
ajst-32569	151	10	disorder	disorder	NOUN
ajst-32569	151	11	or	or	CCONJ
ajst-32569	151	12	depressive	depressive	ADJ
ajst-32569	151	13	symptoms	symptom	NOUN
ajst-32569	151	14	:	:	PUNCT
ajst-32569	151	15	a	a	DET
ajst-32569	151	16	metaanalysis	metaanalysis	NOUN
ajst-32569	151	17	of	of	ADP
ajst-32569	151	18	clinical	clinical	ADJ
ajst-32569	151	19	trials	trial	NOUN
ajst-32569	151	20	.	.	PUNCT
ajst-32569	152	1	acta	acta	PROPN
ajst-32569	152	2	psychiatrica	psychiatrica	PROPN
ajst-32569	152	3	scandinavica	scandinavica	PROPN
ajst-32569	152	4	,	,	PUNCT
ajst-32569	152	5	139(5	139(5	NUM
ajst-32569	152	6	)	)	PUNCT
ajst-32569	152	7	,	,	PUNCT
ajst-32569	152	8	404–419	404–419	NUM
ajst-32569	152	9	.	.	PUNCT
ajst-32569	153	1	[	[	X
ajst-32569	153	2	18	18	NUM
ajst-32569	153	3	]	]	SYM
ajst-32569	153	4	raison	raison	NOUN
ajst-32569	153	5	,	,	PUNCT
ajst-32569	153	6	c.	c.	PROPN
ajst-32569	153	7	l.	l.	PROPN
ajst-32569	153	8	,	,	PUNCT
ajst-32569	153	9	borisov	borisov	PROPN
ajst-32569	153	10	,	,	PUNCT
ajst-32569	153	11	a.	a.	PROPN
ajst-32569	153	12	s.	s.	PROPN
ajst-32569	153	13	,	,	PUNCT
ajst-32569	153	14	broadwell	broadwell	PROPN
ajst-32569	153	15	,	,	PUNCT
ajst-32569	153	16	s.	s.	PROPN
ajst-32569	153	17	d.	d.	PROPN
ajst-32569	153	18	,	,	PUNCT
ajst-32569	153	19	capuron	capuron	PROPN
ajst-32569	153	20	,	,	PUNCT
ajst-32569	153	21	l.	l.	PROPN
ajst-32569	153	22	,	,	PUNCT
ajst-32569	153	23	woolwine	woolwine	NOUN
ajst-32569	153	24	,	,	PUNCT
ajst-32569	153	25	b.	b.	PROPN
ajst-32569	153	26	j.	j.	PROPN
ajst-32569	153	27	,	,	PUNCT
ajst-32569	153	28	jacobson	jacobson	PROPN
ajst-32569	153	29	,	,	PUNCT
ajst-32569	153	30	i.	i.	PROPN
ajst-32569	153	31	m.	m.	PROPN
ajst-32569	153	32	,	,	PUNCT
ajst-32569	153	33	...	...	PUNCT
ajst-32569	153	34	&	&	CCONJ
ajst-32569	153	35	miller	miller	PROPN
ajst-32569	153	36	,	,	PUNCT
ajst-32569	153	37	a.	a.	PROPN
ajst-32569	153	38	h.	h.	PROPN
ajst-32569	153	39	(	(	PUNCT
ajst-32569	153	40	2009	2009	NUM
ajst-32569	153	41	)	)	PUNCT
ajst-32569	153	42	.	.	PUNCT
ajst-32569	154	1	activation	activation	NOUN
ajst-32569	154	2	of	of	ADP
ajst-32569	154	3	central	central	ADJ
ajst-32569	154	4	nervous	nervous	ADJ
ajst-32569	154	5	system	system	NOUN
ajst-32569	154	6	inflammatory	inflammatory	ADJ
ajst-32569	154	7	pathways	pathway	NOUN
ajst-32569	154	8	by	by	ADP
ajst-32569	154	9	interferon	interferon	ADJ
ajst-32569	154	10	-	-	PUNCT
ajst-32569	154	11	alpha	alpha	NOUN
ajst-32569	154	12	:	:	PUNCT
ajst-32569	154	13	relationship	relationship	NOUN
ajst-32569	154	14	to	to	ADP
ajst-32569	154	15	monoamines	monoamine	NOUN
ajst-32569	154	16	and	and	CCONJ
ajst-32569	154	17	depression	depression	NOUN
ajst-32569	154	18	.	.	PUNCT
ajst-32569	155	1	biological	biological	ADJ
ajst-32569	155	2	psychiatry	psychiatry	NOUN
ajst-32569	155	3	,	,	PUNCT
ajst-32569	155	4	65(4	65(4	PROPN
ajst-32569	155	5	)	)	PUNCT
ajst-32569	155	6	,	,	PUNCT
ajst-32569	155	7	296–303	296–303	NUM
ajst-32569	155	8	.	.	PUNCT