id	sid	tid	token	lemma	pos
ajst-32574	1	1	205	205	NUM
ajst-32574	1	2	environmental	environmental	ADJ
ajst-32574	1	3	triggers	trigger	NOUN
ajst-32574	1	4	and	and	CCONJ
ajst-32574	1	5	epigenetic	epigenetic	ADJ
ajst-32574	1	6	regulation	regulation	NOUN
ajst-32574	1	7	in	in	ADP
ajst-32574	1	8	type	type	NOUN
ajst-32574	1	9	1	1	NUM
ajst-32574	1	10	diabetes	diabete	NOUN
ajst-32574	1	11	:	:	PUNCT
ajst-32574	1	12	a	a	DET
ajst-32574	1	13	review	review	NOUN
ajst-32574	1	14	fuxin	fuxin	NOUN
ajst-32574	1	15	chai	chai	PROPN
ajst-32574	1	16	department	department	PROPN
ajst-32574	1	17	of	of	ADP
ajst-32574	1	18	statistics	statistic	NOUN
ajst-32574	1	19	and	and	CCONJ
ajst-32574	1	20	probability	probability	NOUN
ajst-32574	1	21	,	,	PUNCT
ajst-32574	1	22	college	college	NOUN
ajst-32574	1	23	of	of	ADP
ajst-32574	1	24	natural	natural	ADJ
ajst-32574	1	25	science	science	NOUN
ajst-32574	1	26	,	,	PUNCT
ajst-32574	1	27	michigan	michigan	PROPN
ajst-32574	1	28	state	state	PROPN
ajst-32574	1	29	university	university	PROPN
ajst-32574	1	30	,	,	PUNCT
ajst-32574	1	31	east	east	PROPN
ajst-32574	1	32	lansing	lansing	PROPN
ajst-32574	1	33	,	,	PUNCT
ajst-32574	1	34	michigan	michigan	PROPN
ajst-32574	1	35	,	,	PUNCT
ajst-32574	1	36	united	united	PROPN
ajst-32574	1	37	states	states	PROPN
ajst-32574	1	38	fuxinchai@hotmail.com	fuxinchai@hotmail.com	X
ajst-32574	2	1	abstract	abstract	ADJ
ajst-32574	2	2	.	.	PUNCT
ajst-32574	3	1	type	type	NOUN
ajst-32574	3	2	1	1	NUM
ajst-32574	3	3	diabetes	diabetes	NOUN
ajst-32574	3	4	(	(	PUNCT
ajst-32574	3	5	t1d	t1d	NOUN
ajst-32574	3	6	)	)	PUNCT
ajst-32574	3	7	arises	arise	VERB
ajst-32574	3	8	from	from	ADP
ajst-32574	3	9	autoimmune	autoimmune	ADJ
ajst-32574	3	10	destruction	destruction	NOUN
ajst-32574	3	11	of	of	ADP
ajst-32574	3	12	pancreatic	pancreatic	ADJ
ajst-32574	3	13	β	β	NOUN
ajst-32574	3	14	-	-	NOUN
ajst-32574	3	15	cells	cell	NOUN
ajst-32574	3	16	,	,	PUNCT
ajst-32574	3	17	yet	yet	CCONJ
ajst-32574	3	18	genetic	genetic	ADJ
ajst-32574	3	19	predisposition	predisposition	NOUN
ajst-32574	3	20	alone	alone	ADV
ajst-32574	3	21	can	can	AUX
ajst-32574	3	22	not	not	PART
ajst-32574	3	23	fully	fully	ADV
ajst-32574	3	24	account	account	VERB
ajst-32574	3	25	for	for	ADP
ajst-32574	3	26	its	its	PRON
ajst-32574	3	27	onset	onset	NOUN
ajst-32574	3	28	.	.	PUNCT
ajst-32574	4	1	environmental	environmental	ADJ
ajst-32574	4	2	triggers	trigger	NOUN
ajst-32574	4	3	and	and	CCONJ
ajst-32574	4	4	epigenetic	epigenetic	ADJ
ajst-32574	4	5	regulation	regulation	NOUN
ajst-32574	4	6	have	have	AUX
ajst-32574	4	7	emerged	emerge	VERB
ajst-32574	4	8	as	as	ADP
ajst-32574	4	9	contributors	contributor	NOUN
ajst-32574	4	10	bridging	bridge	VERB
ajst-32574	4	11	external	external	ADJ
ajst-32574	4	12	exposures	exposure	NOUN
ajst-32574	4	13	with	with	ADP
ajst-32574	4	14	immune	immune	ADJ
ajst-32574	4	15	and	and	CCONJ
ajst-32574	4	16	metabolic	metabolic	ADJ
ajst-32574	4	17	dysfunction	dysfunction	NOUN
ajst-32574	4	18	.	.	PUNCT
ajst-32574	5	1	this	this	DET
ajst-32574	5	2	review	review	NOUN
ajst-32574	5	3	synthesizes	synthesize	VERB
ajst-32574	5	4	current	current	ADJ
ajst-32574	5	5	evidence	evidence	NOUN
ajst-32574	5	6	on	on	ADP
ajst-32574	5	7	three	three	NUM
ajst-32574	5	8	major	major	ADJ
ajst-32574	5	9	non	non	ADJ
ajst-32574	5	10	-	-	ADJ
ajst-32574	5	11	genetic	genetic	ADJ
ajst-32574	5	12	domains	domain	NOUN
ajst-32574	5	13	influencing	influence	VERB
ajst-32574	5	14	t1d	t1d	PROPN
ajst-32574	5	15	pathogenesis	pathogenesis	NOUN
ajst-32574	5	16	.	.	PUNCT
ajst-32574	6	1	the	the	DET
ajst-32574	6	2	environmental	environmental	ADJ
ajst-32574	6	3	triggers	trigger	NOUN
ajst-32574	6	4	section	section	NOUN
ajst-32574	6	5	focuses	focus	VERB
ajst-32574	6	6	on	on	ADP
ajst-32574	6	7	vitamin	vitamin	NOUN
ajst-32574	6	8	d	d	NOUN
ajst-32574	6	9	and	and	CCONJ
ajst-32574	6	10	enterovirus	enterovirus	NOUN
ajst-32574	6	11	.	.	PUNCT
ajst-32574	7	1	vitamin	vitamin	NOUN
ajst-32574	7	2	d	d	NOUN
ajst-32574	7	3	is	be	AUX
ajst-32574	7	4	discussed	discuss	VERB
ajst-32574	7	5	for	for	ADP
ajst-32574	7	6	its	its	PRON
ajst-32574	7	7	potential	potential	ADJ
ajst-32574	7	8	role	role	NOUN
ajst-32574	7	9	in	in	ADP
ajst-32574	7	10	immune	immune	ADJ
ajst-32574	7	11	tolerance	tolerance	NOUN
ajst-32574	7	12	,	,	PUNCT
ajst-32574	7	13	while	while	SCONJ
ajst-32574	7	14	enterovirus	enterovirus	NOUN
ajst-32574	7	15	represents	represent	VERB
ajst-32574	7	16	a	a	DET
ajst-32574	7	17	well	well	ADV
ajst-32574	7	18	-	-	PUNCT
ajst-32574	7	19	supported	support	VERB
ajst-32574	7	20	infectious	infectious	ADJ
ajst-32574	7	21	trigger	trigger	NOUN
ajst-32574	7	22	associated	associate	VERB
ajst-32574	7	23	with	with	ADP
ajst-32574	7	24	β	β	NOUN
ajst-32574	7	25	-	-	NOUN
ajst-32574	7	26	cell	cell	NOUN
ajst-32574	7	27	autoimmunity	autoimmunity	NOUN
ajst-32574	7	28	.	.	PUNCT
ajst-32574	8	1	the	the	DET
ajst-32574	8	2	epigenetic	epigenetic	ADJ
ajst-32574	8	3	regulation	regulation	NOUN
ajst-32574	8	4	section	section	NOUN
ajst-32574	8	5	highlights	highlight	NOUN
ajst-32574	8	6	how	how	SCONJ
ajst-32574	8	7	epigenetic	epigenetic	ADJ
ajst-32574	8	8	and	and	CCONJ
ajst-32574	8	9	multi	multi	ADJ
ajst-32574	8	10	-	-	ADJ
ajst-32574	8	11	omics	omics	ADJ
ajst-32574	8	12	studies	study	NOUN
ajst-32574	8	13	reveal	reveal	VERB
ajst-32574	8	14	and	and	CCONJ
ajst-32574	8	15	associate	associate	VERB
ajst-32574	8	16	with	with	ADP
ajst-32574	8	17	biological	biological	ADJ
ajst-32574	8	18	mechanisms	mechanism	NOUN
ajst-32574	8	19	and	and	CCONJ
ajst-32574	8	20	t1d	t1d	NOUN
ajst-32574	8	21	onset	onset	NOUN
ajst-32574	8	22	,	,	PUNCT
ajst-32574	8	23	via	via	ADP
ajst-32574	8	24	dna	dna	PROPN
ajst-32574	8	25	methylation	methylation	NOUN
ajst-32574	8	26	,	,	PUNCT
ajst-32574	8	27	histone	histone	NOUN
ajst-32574	8	28	modification	modification	NOUN
ajst-32574	8	29	,	,	PUNCT
ajst-32574	8	30	and	and	CCONJ
ajst-32574	8	31	non	non	ADJ
ajst-32574	8	32	-	-	ADJ
ajst-32574	8	33	coding	code	VERB
ajst-32574	8	34	rna	rna	NOUN
ajst-32574	8	35	pathways	pathway	NOUN
ajst-32574	8	36	.	.	PUNCT
ajst-32574	9	1	collectively	collectively	ADV
ajst-32574	9	2	,	,	PUNCT
ajst-32574	9	3	these	these	DET
ajst-32574	9	4	perspectives	perspective	NOUN
ajst-32574	9	5	illustrate	illustrate	VERB
ajst-32574	9	6	how	how	SCONJ
ajst-32574	9	7	environmental	environmental	ADJ
ajst-32574	9	8	exposures	exposure	NOUN
ajst-32574	9	9	can	can	AUX
ajst-32574	9	10	influence	influence	VERB
ajst-32574	9	11	immune	immune	ADJ
ajst-32574	9	12	and	and	CCONJ
ajst-32574	9	13	transcriptional	transcriptional	ADJ
ajst-32574	9	14	networks	network	NOUN
ajst-32574	9	15	beyond	beyond	ADP
ajst-32574	9	16	genetic	genetic	ADJ
ajst-32574	9	17	susceptibility	susceptibility	NOUN
ajst-32574	9	18	.	.	PUNCT
ajst-32574	10	1	the	the	DET
ajst-32574	10	2	review	review	NOUN
ajst-32574	10	3	concludes	conclude	VERB
ajst-32574	10	4	by	by	ADP
ajst-32574	10	5	outlining	outline	VERB
ajst-32574	10	6	future	future	ADJ
ajst-32574	10	7	research	research	NOUN
ajst-32574	10	8	priorities	priority	NOUN
ajst-32574	10	9	,	,	PUNCT
ajst-32574	10	10	including	include	VERB
ajst-32574	10	11	longitudinal	longitudinal	ADJ
ajst-32574	10	12	multi	multi	ADJ
ajst-32574	10	13	-	-	ADJ
ajst-32574	10	14	omics	omics	ADJ
ajst-32574	10	15	studies	study	NOUN
ajst-32574	10	16	and	and	CCONJ
ajst-32574	10	17	the	the	DET
ajst-32574	10	18	identification	identification	NOUN
ajst-32574	10	19	of	of	ADP
ajst-32574	10	20	modifiable	modifiable	ADJ
ajst-32574	10	21	epigenetic	epigenetic	ADJ
ajst-32574	10	22	biomarkers	biomarker	NOUN
ajst-32574	10	23	,	,	PUNCT
ajst-32574	10	24	which	which	PRON
ajst-32574	10	25	may	may	AUX
ajst-32574	10	26	provide	provide	VERB
ajst-32574	10	27	new	new	ADJ
ajst-32574	10	28	insights	insight	NOUN
ajst-32574	10	29	in	in	ADP
ajst-32574	10	30	exploring	explore	VERB
ajst-32574	10	31	disease	disease	NOUN
ajst-32574	10	32	mechanisms	mechanism	NOUN
ajst-32574	10	33	and	and	CCONJ
ajst-32574	10	34	foster	foster	VERB
ajst-32574	10	35	the	the	DET
ajst-32574	10	36	development	development	NOUN
ajst-32574	10	37	of	of	ADP
ajst-32574	10	38	targeted	target	VERB
ajst-32574	10	39	prevention	prevention	NOUN
ajst-32574	10	40	and	and	CCONJ
ajst-32574	10	41	therapeutic	therapeutic	ADJ
ajst-32574	10	42	strategies	strategy	NOUN
ajst-32574	10	43	for	for	ADP
ajst-32574	10	44	t1d	t1d	PROPN
ajst-32574	10	45	.	.	PUNCT
ajst-32574	11	1	keywords	keyword	NOUN
ajst-32574	11	2	:	:	PUNCT
ajst-32574	11	3	type	type	NOUN
ajst-32574	11	4	1	1	NUM
ajst-32574	11	5	diabetes	diabete	NOUN
ajst-32574	11	6	;	;	PUNCT
ajst-32574	11	7	vitamin	vitamin	NOUN
ajst-32574	11	8	d	d	NOUN
ajst-32574	11	9	;	;	PUNCT
ajst-32574	11	10	enterovirus	enterovirus	NOUN
ajst-32574	11	11	infection	infection	NOUN
ajst-32574	11	12	;	;	PUNCT
ajst-32574	11	13	epidemiology	epidemiology	NOUN
ajst-32574	11	14	.	.	PUNCT
ajst-32574	12	1	1	1	X
ajst-32574	12	2	.	.	X
ajst-32574	12	3	introduction	introduction	NOUN
ajst-32574	12	4	type	type	NOUN
ajst-32574	12	5	1	1	NUM
ajst-32574	12	6	diabetes	diabetes	NOUN
ajst-32574	12	7	is	be	AUX
ajst-32574	12	8	a	a	DET
ajst-32574	12	9	chronic	chronic	ADJ
ajst-32574	12	10	autoimmune	autoimmune	ADJ
ajst-32574	12	11	disorder	disorder	NOUN
ajst-32574	12	12	characterized	characterize	VERB
ajst-32574	12	13	by	by	ADP
ajst-32574	12	14	immune	immune	NOUN
ajst-32574	12	15	-	-	PUNCT
ajst-32574	12	16	mediated	mediate	VERB
ajst-32574	12	17	destruction	destruction	NOUN
ajst-32574	12	18	of	of	ADP
ajst-32574	12	19	pancreatic	pancreatic	ADJ
ajst-32574	12	20	β	β	NOUN
ajst-32574	12	21	-	-	NOUN
ajst-32574	12	22	cells	cell	NOUN
ajst-32574	12	23	,	,	PUNCT
ajst-32574	12	24	resulting	result	VERB
ajst-32574	12	25	in	in	ADP
ajst-32574	12	26	insulin	insulin	NOUN
ajst-32574	12	27	dependence	dependence	NOUN
ajst-32574	12	28	.	.	PUNCT
ajst-32574	13	1	over	over	ADP
ajst-32574	13	2	the	the	DET
ajst-32574	13	3	past	past	ADJ
ajst-32574	13	4	fifty	fifty	NUM
ajst-32574	13	5	years	year	NOUN
ajst-32574	13	6	,	,	PUNCT
ajst-32574	13	7	research	research	NOUN
ajst-32574	13	8	on	on	ADP
ajst-32574	13	9	hla	hla	PROPN
ajst-32574	13	10	gene	gene	NOUN
ajst-32574	13	11	associations	association	NOUN
ajst-32574	13	12	has	have	AUX
ajst-32574	13	13	laid	lay	VERB
ajst-32574	13	14	the	the	DET
ajst-32574	13	15	foundation	foundation	NOUN
ajst-32574	13	16	for	for	ADP
ajst-32574	13	17	our	our	PRON
ajst-32574	13	18	understanding	understanding	NOUN
ajst-32574	13	19	of	of	ADP
ajst-32574	13	20	t1d	t1d	PROPN
ajst-32574	13	21	genetic	genetic	ADJ
ajst-32574	13	22	risk	risk	NOUN
ajst-32574	13	23	[	[	X
ajst-32574	13	24	1	1	NUM
ajst-32574	13	25	]	]	PUNCT
ajst-32574	13	26	.	.	PUNCT
ajst-32574	14	1	the	the	DET
ajst-32574	14	2	hla	hla	PROPN
ajst-32574	14	3	region	region	NOUN
ajst-32574	14	4	remains	remain	VERB
ajst-32574	14	5	the	the	DET
ajst-32574	14	6	strongest	strong	ADJ
ajst-32574	14	7	known	know	VERB
ajst-32574	14	8	genetic	genetic	ADJ
ajst-32574	14	9	contributor	contributor	NOUN
ajst-32574	14	10	[	[	X
ajst-32574	14	11	2][3	2][3	X
ajst-32574	14	12	]	]	X
ajst-32574	14	13	.	.	PUNCT
ajst-32574	15	1	however	however	ADV
ajst-32574	15	2	,	,	PUNCT
ajst-32574	15	3	even	even	ADV
ajst-32574	15	4	among	among	ADP
ajst-32574	15	5	monozygotic	monozygotic	ADJ
ajst-32574	15	6	twins	twin	NOUN
ajst-32574	15	7	,	,	PUNCT
ajst-32574	15	8	disease	disease	NOUN
ajst-32574	15	9	discordance	discordance	NOUN
ajst-32574	15	10	is	be	AUX
ajst-32574	15	11	frequently	frequently	ADV
ajst-32574	15	12	observed	observe	VERB
ajst-32574	15	13	[	[	X
ajst-32574	15	14	4	4	NUM
ajst-32574	15	15	]	]	PUNCT
ajst-32574	15	16	,	,	PUNCT
ajst-32574	15	17	indicating	indicate	VERB
ajst-32574	15	18	that	that	SCONJ
ajst-32574	15	19	non	non	ADJ
ajst-32574	15	20	-	-	ADJ
ajst-32574	15	21	genetic	genetic	ADJ
ajst-32574	15	22	factors	factor	NOUN
ajst-32574	15	23	play	play	VERB
ajst-32574	15	24	a	a	DET
ajst-32574	15	25	key	key	ADJ
ajst-32574	15	26	role	role	NOUN
ajst-32574	15	27	in	in	ADP
ajst-32574	15	28	disease	disease	NOUN
ajst-32574	15	29	initiation	initiation	NOUN
ajst-32574	15	30	and	and	CCONJ
ajst-32574	15	31	progression	progression	NOUN
ajst-32574	15	32	.	.	PUNCT
ajst-32574	16	1	large	large	ADJ
ajst-32574	16	2	-	-	PUNCT
ajst-32574	16	3	scale	scale	NOUN
ajst-32574	16	4	prospective	prospective	ADJ
ajst-32574	16	5	efforts	effort	NOUN
ajst-32574	16	6	systematically	systematically	ADV
ajst-32574	16	7	evaluate	evaluate	VERB
ajst-32574	16	8	early	early	ADJ
ajst-32574	16	9	-	-	PUNCT
ajst-32574	16	10	life	life	NOUN
ajst-32574	16	11	environmental	environmental	ADJ
ajst-32574	16	12	exposures	exposure	NOUN
ajst-32574	16	13	and	and	CCONJ
ajst-32574	16	14	their	their	PRON
ajst-32574	16	15	relationships	relationship	NOUN
ajst-32574	16	16	with	with	ADP
ajst-32574	16	17	islet	islet	NOUN
ajst-32574	16	18	autoimmunity	autoimmunity	NOUN
ajst-32574	16	19	and	and	CCONJ
ajst-32574	16	20	the	the	DET
ajst-32574	16	21	onset	onset	NOUN
ajst-32574	16	22	of	of	ADP
ajst-32574	16	23	type	type	NOUN
ajst-32574	16	24	1	1	NUM
ajst-32574	16	25	diabetes	diabetes	NOUN
ajst-32574	16	26	(	(	PUNCT
ajst-32574	16	27	t1d	t1d	NOUN
ajst-32574	16	28	)	)	PUNCT
ajst-32574	17	1	[	[	X
ajst-32574	17	2	5	5	NUM
ajst-32574	17	3	]	]	PUNCT
ajst-32574	17	4	.	.	PUNCT
ajst-32574	18	1	among	among	ADP
ajst-32574	18	2	these	these	DET
ajst-32574	18	3	environmental	environmental	ADJ
ajst-32574	18	4	candidates	candidate	NOUN
ajst-32574	18	5	,	,	PUNCT
ajst-32574	18	6	vitamin	vitamin	NOUN
ajst-32574	18	7	d	d	NOUN
ajst-32574	18	8	status	status	NOUN
ajst-32574	18	9	and	and	CCONJ
ajst-32574	18	10	enteroviral	enteroviral	ADJ
ajst-32574	18	11	infection	infection	NOUN
ajst-32574	18	12	are	be	AUX
ajst-32574	18	13	the	the	DET
ajst-32574	18	14	two	two	NUM
ajst-32574	18	15	triggers	trigger	NOUN
ajst-32574	18	16	that	that	PRON
ajst-32574	18	17	have	have	AUX
ajst-32574	18	18	been	be	AUX
ajst-32574	18	19	intensively	intensively	ADV
ajst-32574	18	20	studied	study	VERB
ajst-32574	18	21	.	.	PUNCT
ajst-32574	19	1	vitamin	vitamin	NOUN
ajst-32574	19	2	d	d	NOUN
ajst-32574	19	3	has	have	AUX
ajst-32574	19	4	been	be	AUX
ajst-32574	19	5	linked	link	VERB
ajst-32574	19	6	in	in	ADP
ajst-32574	19	7	numerous	numerous	ADJ
ajst-32574	19	8	observational	observational	ADJ
ajst-32574	19	9	studies	study	NOUN
ajst-32574	19	10	to	to	ADP
ajst-32574	19	11	the	the	DET
ajst-32574	19	12	risk	risk	NOUN
ajst-32574	19	13	of	of	ADP
ajst-32574	19	14	t1d	t1d	PROPN
ajst-32574	19	15	,	,	PUNCT
ajst-32574	19	16	yet	yet	CCONJ
ajst-32574	19	17	causality	causality	NOUN
ajst-32574	19	18	remains	remain	VERB
ajst-32574	19	19	debated	debate	VERB
ajst-32574	19	20	.	.	PUNCT
ajst-32574	20	1	in	in	ADP
ajst-32574	20	2	contrast	contrast	NOUN
ajst-32574	20	3	,	,	PUNCT
ajst-32574	20	4	enteroviruses	enterovirus	NOUN
ajst-32574	20	5	get	get	VERB
ajst-32574	20	6	more	more	ADV
ajst-32574	20	7	consistent	consistent	ADJ
ajst-32574	20	8	epidemiological	epidemiological	ADJ
ajst-32574	20	9	and	and	CCONJ
ajst-32574	20	10	pathological	pathological	ADJ
ajst-32574	20	11	support	support	NOUN
ajst-32574	20	12	as	as	ADP
ajst-32574	20	13	instigators	instigator	NOUN
ajst-32574	20	14	of	of	ADP
ajst-32574	20	15	islet	islet	NOUN
ajst-32574	20	16	autoimmunity	autoimmunity	NOUN
ajst-32574	20	17	,	,	PUNCT
ajst-32574	20	18	potentially	potentially	ADV
ajst-32574	20	19	via	via	ADP
ajst-32574	20	20	well	well	ADV
ajst-32574	20	21	-	-	PUNCT
ajst-32574	20	22	defined	define	VERB
ajst-32574	20	23	mechanisms	mechanism	NOUN
ajst-32574	20	24	.	.	PUNCT
ajst-32574	21	1	these	these	DET
ajst-32574	21	2	two	two	NUM
ajst-32574	21	3	factors	factor	NOUN
ajst-32574	21	4	thus	thus	ADV
ajst-32574	21	5	represent	represent	VERB
ajst-32574	21	6	complementary	complementary	ADJ
ajst-32574	21	7	vantage	vantage	NOUN
ajst-32574	21	8	points	point	NOUN
ajst-32574	21	9	,	,	PUNCT
ajst-32574	21	10	one	one	NOUN
ajst-32574	21	11	reflecting	reflect	VERB
ajst-32574	21	12	uncertainty	uncertainty	NOUN
ajst-32574	21	13	in	in	ADP
ajst-32574	21	14	mechanism	mechanism	NOUN
ajst-32574	21	15	,	,	PUNCT
ajst-32574	21	16	the	the	DET
ajst-32574	21	17	other	other	ADJ
ajst-32574	21	18	elucidating	elucidate	VERB
ajst-32574	21	19	a	a	DET
ajst-32574	21	20	stronger	strong	ADJ
ajst-32574	21	21	mechanistic	mechanistic	ADJ
ajst-32574	21	22	hypothesis	hypothesis	NOUN
ajst-32574	21	23	.	.	PUNCT
ajst-32574	22	1	despite	despite	SCONJ
ajst-32574	22	2	substantial	substantial	ADJ
ajst-32574	22	3	effort	effort	NOUN
ajst-32574	22	4	into	into	ADP
ajst-32574	22	5	environmental	environmental	ADJ
ajst-32574	22	6	association	association	NOUN
ajst-32574	22	7	studies	study	NOUN
ajst-32574	22	8	,	,	PUNCT
ajst-32574	22	9	the	the	DET
ajst-32574	22	10	bridge	bridge	NOUN
ajst-32574	22	11	from	from	ADP
ajst-32574	22	12	external	external	ADJ
ajst-32574	22	13	exposures	exposure	NOUN
ajst-32574	22	14	to	to	ADP
ajst-32574	22	15	immune	immune	NOUN
ajst-32574	22	16	-	-	PUNCT
ajst-32574	22	17	regulating	regulating	NOUN
ajst-32574	22	18	remains	remain	VERB
ajst-32574	22	19	largely	largely	ADV
ajst-32574	22	20	speculative	speculative	ADJ
ajst-32574	22	21	.	.	PUNCT
ajst-32574	23	1	to	to	PART
ajst-32574	23	2	understand	understand	VERB
ajst-32574	23	3	how	how	SCONJ
ajst-32574	23	4	environmental	environmental	ADJ
ajst-32574	23	5	factors	factor	NOUN
ajst-32574	23	6	contribute	contribute	VERB
ajst-32574	23	7	to	to	ADP
ajst-32574	23	8	autoimmunity	autoimmunity	NOUN
ajst-32574	23	9	and	and	CCONJ
ajst-32574	23	10	β	β	NOUN
ajst-32574	23	11	-	-	NOUN
ajst-32574	23	12	cell	cell	NOUN
ajst-32574	23	13	injury	injury	NOUN
ajst-32574	23	14	,	,	PUNCT
ajst-32574	23	15	epigenetic	epigenetic	ADJ
ajst-32574	23	16	regulation	regulation	NOUN
ajst-32574	23	17	offers	offer	VERB
ajst-32574	23	18	a	a	DET
ajst-32574	23	19	compelling	compelling	ADJ
ajst-32574	23	20	interface	interface	NOUN
ajst-32574	23	21	.	.	PUNCT
ajst-32574	24	1	dna	dna	PROPN
ajst-32574	24	2	methylation	methylation	NOUN
ajst-32574	24	3	,	,	PUNCT
ajst-32574	24	4	histone	histone	NOUN
ajst-32574	24	5	modifications	modification	NOUN
ajst-32574	24	6	,	,	PUNCT
ajst-32574	24	7	and	and	CCONJ
ajst-32574	24	8	non	non	ADJ
ajst-32574	24	9	-	-	ADJ
ajst-32574	24	10	coding	coding	ADJ
ajst-32574	24	11	rnas	rna	NOUN
ajst-32574	24	12	mediate	mediate	VERB
ajst-32574	24	13	how	how	SCONJ
ajst-32574	24	14	environmental	environmental	ADJ
ajst-32574	24	15	inputs	input	NOUN
ajst-32574	24	16	can	can	AUX
ajst-32574	24	17	stably	stably	ADV
ajst-32574	24	18	modulate	modulate	VERB
ajst-32574	24	19	gene	gene	NOUN
ajst-32574	24	20	expression	expression	NOUN
ajst-32574	24	21	without	without	ADP
ajst-32574	24	22	altering	alter	VERB
ajst-32574	24	23	the	the	DET
ajst-32574	24	24	dna	dna	PROPN
ajst-32574	24	25	sequence	sequence	NOUN
ajst-32574	24	26	.	.	PUNCT
ajst-32574	25	1	as	as	SCONJ
ajst-32574	25	2	argued	argue	VERB
ajst-32574	25	3	by	by	ADP
ajst-32574	25	4	minniakhmetov	minniakhmetov	PROPN
ajst-32574	25	5	et	et	PROPN
ajst-32574	25	6	al	al	PROPN
ajst-32574	25	7	.	.	PUNCT
ajst-32574	26	1	[	[	X
ajst-32574	26	2	6	6	NUM
ajst-32574	26	3	]	]	PUNCT
ajst-32574	26	4	,	,	PUNCT
ajst-32574	26	5	a	a	DET
ajst-32574	26	6	modern	modern	ADJ
ajst-32574	26	7	view	view	NOUN
ajst-32574	26	8	of	of	ADP
ajst-32574	26	9	t1d	t1d	PROPN
ajst-32574	26	10	etiology	etiology	NOUN
ajst-32574	26	11	necessarily	necessarily	ADV
ajst-32574	26	12	integrates	integrate	VERB
ajst-32574	26	13	both	both	CCONJ
ajst-32574	26	14	genetic	genetic	ADJ
ajst-32574	26	15	and	and	CCONJ
ajst-32574	26	16	epigenetic	epigenetic	ADJ
ajst-32574	26	17	dimensions	dimension	NOUN
ajst-32574	26	18	,	,	PUNCT
ajst-32574	26	19	highlighting	highlight	VERB
ajst-32574	26	20	that	that	SCONJ
ajst-32574	26	21	epigenetic	epigenetic	ADJ
ajst-32574	26	22	remodeling	remodeling	NOUN
ajst-32574	26	23	may	may	AUX
ajst-32574	26	24	act	act	VERB
ajst-32574	26	25	as	as	ADP
ajst-32574	26	26	a	a	DET
ajst-32574	26	27	mediator	mediator	NOUN
ajst-32574	26	28	of	of	ADP
ajst-32574	26	29	environmental	environmental	ADJ
ajst-32574	26	30	influence	influence	NOUN
ajst-32574	26	31	.	.	PUNCT
ajst-32574	27	1	the	the	DET
ajst-32574	27	2	multi	multi	ADJ
ajst-32574	27	3	-	-	ADJ
ajst-32574	27	4	omics	omics	ADJ
ajst-32574	27	5	approaches	approach	NOUN
ajst-32574	27	6	link	link	VERB
ajst-32574	27	7	the	the	DET
ajst-32574	27	8	genome	genome	NOUN
ajst-32574	27	9	,	,	PUNCT
ajst-32574	27	10	epigenome	epigenome	NOUN
ajst-32574	27	11	,	,	PUNCT
ajst-32574	27	12	transcriptome	transcriptome	NOUN
ajst-32574	27	13	,	,	PUNCT
ajst-32574	27	14	and	and	CCONJ
ajst-32574	27	15	metabolome	metabolome	NOUN
ajst-32574	27	16	.	.	PUNCT
ajst-32574	28	1	in	in	ADP
ajst-32574	28	2	light	light	NOUN
ajst-32574	28	3	of	of	ADP
ajst-32574	28	4	these	these	DET
ajst-32574	28	5	considerations	consideration	NOUN
ajst-32574	28	6	,	,	PUNCT
ajst-32574	28	7	this	this	DET
ajst-32574	28	8	review	review	NOUN
ajst-32574	28	9	aims	aim	VERB
ajst-32574	28	10	to	to	PART
ajst-32574	28	11	synthesize	synthesize	VERB
ajst-32574	28	12	the	the	DET
ajst-32574	28	13	current	current	ADJ
ajst-32574	28	14	evidence	evidence	NOUN
ajst-32574	28	15	on	on	ADP
ajst-32574	28	16	non	non	ADJ
ajst-32574	28	17	-	-	ADJ
ajst-32574	28	18	genetic	genetic	ADJ
ajst-32574	28	19	determinants	determinant	NOUN
ajst-32574	28	20	of	of	ADP
ajst-32574	28	21	t1d	t1d	NOUN
ajst-32574	28	22	by	by	ADP
ajst-32574	28	23	focusing	focus	VERB
ajst-32574	28	24	on	on	ADP
ajst-32574	28	25	three	three	NUM
ajst-32574	28	26	principal	principal	ADJ
ajst-32574	28	27	domains	domain	NOUN
ajst-32574	28	28	:	:	PUNCT
ajst-32574	28	29	vitamin	vitamin	NOUN
ajst-32574	28	30	d	d	PROPN
ajst-32574	28	31	,	,	PUNCT
ajst-32574	28	32	representing	represent	VERB
ajst-32574	28	33	a	a	DET
ajst-32574	28	34	widespread	widespread	ADJ
ajst-32574	28	35	206	206	NUM
ajst-32574	28	36	but	but	CCONJ
ajst-32574	28	37	mechanistically	mechanistically	ADV
ajst-32574	28	38	uncertain	uncertain	ADJ
ajst-32574	28	39	environmental	environmental	ADJ
ajst-32574	28	40	factor	factor	NOUN
ajst-32574	28	41	;	;	PUNCT
ajst-32574	28	42	enterovirus	enterovirus	NOUN
ajst-32574	28	43	,	,	PUNCT
ajst-32574	28	44	typifying	typify	VERB
ajst-32574	28	45	a	a	DET
ajst-32574	28	46	clear	clear	ADJ
ajst-32574	28	47	infectious	infectious	ADJ
ajst-32574	28	48	trigger	trigger	NOUN
ajst-32574	28	49	with	with	ADP
ajst-32574	28	50	unclear	unclear	ADJ
ajst-32574	28	51	mechanistic	mechanistic	ADJ
ajst-32574	28	52	pathways	pathway	NOUN
ajst-32574	28	53	;	;	PUNCT
ajst-32574	28	54	epigenetic	epigenetic	ADJ
ajst-32574	28	55	and	and	CCONJ
ajst-32574	28	56	omics	omic	NOUN
ajst-32574	28	57	approaches	approach	NOUN
ajst-32574	28	58	,	,	PUNCT
ajst-32574	28	59	bridging	bridge	VERB
ajst-32574	28	60	environmental	environmental	ADJ
ajst-32574	28	61	exposure	exposure	NOUN
ajst-32574	28	62	with	with	ADP
ajst-32574	28	63	gene	gene	NOUN
ajst-32574	28	64	regulation	regulation	NOUN
ajst-32574	28	65	and	and	CCONJ
ajst-32574	28	66	immune	immune	ADJ
ajst-32574	28	67	response	response	NOUN
ajst-32574	28	68	.	.	PUNCT
ajst-32574	29	1	this	this	DET
ajst-32574	29	2	review	review	NOUN
ajst-32574	29	3	examines	examine	VERB
ajst-32574	29	4	how	how	SCONJ
ajst-32574	29	5	environmental	environmental	ADJ
ajst-32574	29	6	and	and	CCONJ
ajst-32574	29	7	epigenetic	epigenetic	ADJ
ajst-32574	29	8	factors	factor	NOUN
ajst-32574	29	9	may	may	AUX
ajst-32574	29	10	converge	converge	VERB
ajst-32574	29	11	to	to	PART
ajst-32574	29	12	influence	influence	VERB
ajst-32574	29	13	t1d	t1d	PROPN
ajst-32574	29	14	susceptibility	susceptibility	NOUN
ajst-32574	29	15	,	,	PUNCT
ajst-32574	29	16	thereby	thereby	ADV
ajst-32574	29	17	laying	lay	VERB
ajst-32574	29	18	the	the	DET
ajst-32574	29	19	groundwork	groundwork	NOUN
ajst-32574	29	20	for	for	ADP
ajst-32574	29	21	mechanistically	mechanistically	ADV
ajst-32574	29	22	informed	inform	VERB
ajst-32574	29	23	prevention	prevention	NOUN
ajst-32574	29	24	and	and	CCONJ
ajst-32574	29	25	intervention	intervention	NOUN
ajst-32574	29	26	strategies	strategy	NOUN
ajst-32574	29	27	through	through	ADP
ajst-32574	29	28	a	a	DET
ajst-32574	29	29	comparative	comparative	ADJ
ajst-32574	29	30	discussion	discussion	NOUN
ajst-32574	29	31	of	of	ADP
ajst-32574	29	32	these	these	DET
ajst-32574	29	33	themes	theme	NOUN
ajst-32574	29	34	.	.	PUNCT
ajst-32574	30	1	2	2	X
ajst-32574	30	2	.	.	X
ajst-32574	30	3	environmental	environmental	ADJ
ajst-32574	30	4	triggers	trigger	NOUN
ajst-32574	30	5	and	and	CCONJ
ajst-32574	30	6	epigenetic	epigenetic	ADJ
ajst-32574	30	7	regulation	regulation	NOUN
ajst-32574	30	8	in	in	ADP
ajst-32574	30	9	type	type	NOUN
ajst-32574	30	10	1	1	NUM
ajst-32574	30	11	diabetes	diabetes	NOUN
ajst-32574	30	12	2.1	2.1	NUM
ajst-32574	30	13	vitamin	vitamin	NOUN
ajst-32574	30	14	d	d	NOUN
ajst-32574	30	15	vitamin	vitamin	NOUN
ajst-32574	30	16	d	d	NOUN
ajst-32574	30	17	has	have	AUX
ajst-32574	30	18	been	be	AUX
ajst-32574	30	19	proposed	propose	VERB
ajst-32574	30	20	as	as	ADP
ajst-32574	30	21	a	a	DET
ajst-32574	30	22	potential	potential	ADJ
ajst-32574	30	23	environmental	environmental	ADJ
ajst-32574	30	24	factor	factor	NOUN
ajst-32574	30	25	influencing	influence	VERB
ajst-32574	30	26	the	the	DET
ajst-32574	30	27	development	development	NOUN
ajst-32574	30	28	of	of	ADP
ajst-32574	30	29	type	type	NOUN
ajst-32574	30	30	1	1	NUM
ajst-32574	30	31	diabetes	diabetes	NOUN
ajst-32574	30	32	.	.	PUNCT
ajst-32574	31	1	vitamin	vitamin	NOUN
ajst-32574	31	2	d	d	PROPN
ajst-32574	31	3	status	status	NOUN
ajst-32574	31	4	is	be	AUX
ajst-32574	31	5	often	often	ADV
ajst-32574	31	6	low	low	ADJ
ajst-32574	31	7	in	in	ADP
ajst-32574	31	8	children	child	NOUN
ajst-32574	31	9	with	with	ADP
ajst-32574	31	10	t1d	t1d	PROPN
ajst-32574	31	11	.	.	PUNCT
ajst-32574	32	1	across	across	ADP
ajst-32574	32	2	cross	cross	ADJ
ajst-32574	32	3	-	-	ADJ
ajst-32574	32	4	sectional	sectional	ADJ
ajst-32574	32	5	and	and	CCONJ
ajst-32574	32	6	case	case	NOUN
ajst-32574	32	7	–	–	PUNCT
ajst-32574	32	8	control	control	NOUN
ajst-32574	32	9	studies	study	NOUN
ajst-32574	32	10	,	,	PUNCT
ajst-32574	32	11	patients	patient	NOUN
ajst-32574	32	12	with	with	ADP
ajst-32574	32	13	type	type	NOUN
ajst-32574	32	14	1	1	NUM
ajst-32574	32	15	diabetes	diabetes	NOUN
ajst-32574	32	16	consistently	consistently	ADV
ajst-32574	32	17	show	show	VERB
ajst-32574	32	18	lower	low	ADJ
ajst-32574	32	19	circulating	circulate	VERB
ajst-32574	32	20	25(oh)d	25(oh)d	NOUN
ajst-32574	32	21	than	than	ADP
ajst-32574	32	22	healthy	healthy	ADJ
ajst-32574	32	23	peers	peer	NOUN
ajst-32574	32	24	.	.	PUNCT
ajst-32574	33	1	a	a	DET
ajst-32574	33	2	meta	meta	ADJ
ajst-32574	33	3	-	-	PUNCT
ajst-32574	33	4	analysis	analysis	NOUN
ajst-32574	33	5	reports	report	NOUN
ajst-32574	33	6	a	a	DET
ajst-32574	33	7	high	high	ADJ
ajst-32574	33	8	prevalence	prevalence	NOUN
ajst-32574	33	9	of	of	ADP
ajst-32574	33	10	deficiency	deficiency	NOUN
ajst-32574	33	11	among	among	ADP
ajst-32574	33	12	pediatric	pediatric	ADJ
ajst-32574	33	13	t1d	t1d	PROPN
ajst-32574	33	14	cohorts	cohort	NOUN
ajst-32574	33	15	,	,	PUNCT
ajst-32574	33	16	with	with	SCONJ
ajst-32574	33	17	approximately	approximately	ADV
ajst-32574	33	18	half	half	NOUN
ajst-32574	33	19	of	of	ADP
ajst-32574	33	20	participants	participant	NOUN
ajst-32574	33	21	affected	affect	VERB
ajst-32574	33	22	[	[	PUNCT
ajst-32574	33	23	7	7	NUM
ajst-32574	33	24	]	]	PUNCT
ajst-32574	33	25	.	.	PUNCT
ajst-32574	34	1	daskalopoulou	daskalopoulou	PROPN
ajst-32574	34	2	et	et	PROPN
ajst-32574	34	3	al	al	PROPN
ajst-32574	34	4	.	.	PUNCT
ajst-32574	35	1	[	[	X
ajst-32574	35	2	8	8	NUM
ajst-32574	35	3	]	]	PUNCT
ajst-32574	35	4	systematically	systematically	ADV
ajst-32574	35	5	reviewed	review	VERB
ajst-32574	35	6	cohort	cohort	NOUN
ajst-32574	35	7	,	,	PUNCT
ajst-32574	35	8	case	case	NOUN
ajst-32574	35	9	–	–	PUNCT
ajst-32574	35	10	control	control	NOUN
ajst-32574	35	11	,	,	PUNCT
ajst-32574	35	12	and	and	CCONJ
ajst-32574	35	13	cross	cross	ADJ
ajst-32574	35	14	-	-	ADJ
ajst-32574	35	15	sectional	sectional	ADJ
ajst-32574	35	16	studies	study	NOUN
ajst-32574	35	17	involving	involve	VERB
ajst-32574	35	18	children	child	NOUN
ajst-32574	35	19	and	and	CCONJ
ajst-32574	35	20	adolescents	adolescent	NOUN
ajst-32574	35	21	(	(	PUNCT
ajst-32574	35	22	≤	≤	ADV
ajst-32574	35	23	15	15	NUM
ajst-32574	35	24	years	year	NOUN
ajst-32574	35	25	)	)	PUNCT
ajst-32574	35	26	and	and	CCONJ
ajst-32574	35	27	found	find	VERB
ajst-32574	35	28	that	that	SCONJ
ajst-32574	35	29	most	most	ADJ
ajst-32574	35	30	studies	study	NOUN
ajst-32574	35	31	reported	report	VERB
ajst-32574	35	32	significantly	significantly	ADV
ajst-32574	35	33	lower	low	ADJ
ajst-32574	35	34	serum	serum	NOUN
ajst-32574	35	35	25(oh)d	25(oh)d	NUM
ajst-32574	35	36	levels	level	NOUN
ajst-32574	35	37	in	in	ADP
ajst-32574	35	38	those	those	PRON
ajst-32574	35	39	who	who	PRON
ajst-32574	35	40	developed	develop	VERB
ajst-32574	35	41	t1d	t1d	PROPN
ajst-32574	35	42	,	,	PUNCT
ajst-32574	35	43	particularly	particularly	ADV
ajst-32574	35	44	among	among	ADP
ajst-32574	35	45	genetically	genetically	ADV
ajst-32574	35	46	predisposed	predispose	VERB
ajst-32574	35	47	individuals	individual	NOUN
ajst-32574	35	48	.	.	PUNCT
ajst-32574	36	1	collectively	collectively	ADV
ajst-32574	36	2	,	,	PUNCT
ajst-32574	36	3	these	these	DET
ajst-32574	36	4	findings	finding	NOUN
ajst-32574	36	5	suggest	suggest	VERB
ajst-32574	36	6	a	a	DET
ajst-32574	36	7	potential	potential	ADJ
ajst-32574	36	8	epidemiological	epidemiological	ADJ
ajst-32574	36	9	association	association	NOUN
ajst-32574	36	10	between	between	ADP
ajst-32574	36	11	low	low	ADJ
ajst-32574	36	12	vitamin	vitamin	NOUN
ajst-32574	36	13	d	d	NOUN
ajst-32574	36	14	levels	level	NOUN
ajst-32574	36	15	and	and	CCONJ
ajst-32574	36	16	an	an	DET
ajst-32574	36	17	increased	increase	VERB
ajst-32574	36	18	susceptibility	susceptibility	NOUN
ajst-32574	36	19	to	to	ADP
ajst-32574	36	20	t1d	t1d	PROPN
ajst-32574	36	21	.	.	PUNCT
ajst-32574	37	1	however	however	ADV
ajst-32574	37	2	,	,	PUNCT
ajst-32574	37	3	the	the	DET
ajst-32574	37	4	strength	strength	NOUN
ajst-32574	37	5	and	and	CCONJ
ajst-32574	37	6	causality	causality	NOUN
ajst-32574	37	7	of	of	ADP
ajst-32574	37	8	this	this	DET
ajst-32574	37	9	relationship	relationship	NOUN
ajst-32574	37	10	remain	remain	VERB
ajst-32574	37	11	debated	debate	VERB
ajst-32574	37	12	,	,	PUNCT
ajst-32574	37	13	as	as	SCONJ
ajst-32574	37	14	other	other	ADJ
ajst-32574	37	15	studies	study	NOUN
ajst-32574	37	16	do	do	AUX
ajst-32574	37	17	not	not	PART
ajst-32574	37	18	support	support	VERB
ajst-32574	37	19	a	a	DET
ajst-32574	37	20	strong	strong	ADJ
ajst-32574	37	21	causal	causal	ADJ
ajst-32574	37	22	relationship	relationship	NOUN
ajst-32574	37	23	between	between	ADP
ajst-32574	37	24	vitamin	vitamin	NOUN
ajst-32574	37	25	d	d	NOUN
ajst-32574	37	26	status	status	NOUN
ajst-32574	37	27	and	and	CCONJ
ajst-32574	37	28	t1d	t1d	PROPN
ajst-32574	37	29	incidence	incidence	NOUN
ajst-32574	37	30	.	.	PUNCT
ajst-32574	38	1	nascimento	nascimento	PROPN
ajst-32574	38	2	et	et	PROPN
ajst-32574	38	3	al	al	PROPN
ajst-32574	38	4	.	.	PUNCT
ajst-32574	39	1	[	[	X
ajst-32574	39	2	9	9	NUM
ajst-32574	39	3	]	]	PUNCT
ajst-32574	39	4	filtered	filter	VERB
ajst-32574	39	5	studies	study	NOUN
ajst-32574	39	6	through	through	ADP
ajst-32574	39	7	a	a	DET
ajst-32574	39	8	systematic	systematic	ADJ
ajst-32574	39	9	review	review	NOUN
ajst-32574	39	10	and	and	CCONJ
ajst-32574	39	11	quality	quality	NOUN
ajst-32574	39	12	assessment	assessment	NOUN
ajst-32574	39	13	,	,	PUNCT
ajst-32574	39	14	finding	find	VERB
ajst-32574	39	15	that	that	SCONJ
ajst-32574	39	16	50	50	NUM
ajst-32574	39	17	%	%	NOUN
ajst-32574	39	18	of	of	ADP
ajst-32574	39	19	studies	study	NOUN
ajst-32574	39	20	yielded	yield	VERB
ajst-32574	39	21	a	a	DET
ajst-32574	39	22	positive	positive	ADJ
ajst-32574	39	23	result	result	NOUN
ajst-32574	39	24	in	in	ADP
ajst-32574	39	25	evaluating	evaluate	VERB
ajst-32574	39	26	the	the	DET
ajst-32574	39	27	effect	effect	NOUN
ajst-32574	39	28	of	of	ADP
ajst-32574	39	29	vitamin	vitamin	NOUN
ajst-32574	39	30	d	d	NOUN
ajst-32574	39	31	supplementation	supplementation	NOUN
ajst-32574	39	32	on	on	ADP
ajst-32574	39	33	hba1c	hba1c	PROPN
ajst-32574	39	34	.	.	PUNCT
ajst-32574	40	1	however	however	ADV
ajst-32574	40	2	,	,	PUNCT
ajst-32574	40	3	only	only	ADV
ajst-32574	40	4	one	one	NUM
ajst-32574	40	5	trial	trial	NOUN
ajst-32574	40	6	was	be	AUX
ajst-32574	40	7	rated	rate	VERB
ajst-32574	40	8	as	as	ADP
ajst-32574	40	9	having	have	VERB
ajst-32574	40	10	positive	positive	ADJ
ajst-32574	40	11	methodological	methodological	ADJ
ajst-32574	40	12	quality	quality	NOUN
ajst-32574	40	13	,	,	PUNCT
ajst-32574	40	14	with	with	ADP
ajst-32574	40	15	inconsistent	inconsistent	ADJ
ajst-32574	40	16	overall	overall	ADJ
ajst-32574	40	17	evidence	evidence	NOUN
ajst-32574	40	18	for	for	ADP
ajst-32574	40	19	glycemic	glycemic	ADJ
ajst-32574	40	20	control	control	NOUN
ajst-32574	40	21	benefits	benefit	NOUN
ajst-32574	40	22	.	.	PUNCT
ajst-32574	41	1	manousaki	manousaki	VERB
ajst-32574	41	2	et	et	PROPN
ajst-32574	41	3	al	al	PROPN
ajst-32574	42	1	[	[	X
ajst-32574	42	2	10	10	NUM
ajst-32574	42	3	]	]	PUNCT
ajst-32574	42	4	indicate	indicate	VERB
ajst-32574	42	5	no	no	DET
ajst-32574	42	6	strong	strong	ADJ
ajst-32574	42	7	causal	causal	ADJ
ajst-32574	42	8	effect	effect	NOUN
ajst-32574	42	9	of	of	ADP
ajst-32574	42	10	genetically	genetically	ADV
ajst-32574	42	11	determined	determine	VERB
ajst-32574	42	12	25(oh)d	25(oh)d	NOUN
ajst-32574	42	13	on	on	ADP
ajst-32574	42	14	t1d	t1d	PROPN
ajst-32574	42	15	risk	risk	NOUN
ajst-32574	42	16	,	,	PUNCT
ajst-32574	42	17	by	by	ADP
ajst-32574	42	18	using	use	VERB
ajst-32574	42	19	a	a	DET
ajst-32574	42	20	two	two	NUM
ajst-32574	42	21	-	-	PUNCT
ajst-32574	42	22	sample	sample	NOUN
ajst-32574	42	23	mendelian	mendelian	ADJ
ajst-32574	42	24	randomization	randomization	NOUN
ajst-32574	42	25	analysis	analysis	NOUN
ajst-32574	42	26	with	with	ADP
ajst-32574	42	27	single	single	ADJ
ajst-32574	42	28	-	-	PUNCT
ajst-32574	42	29	nucleotide	nucleotide	ADJ
ajst-32574	42	30	polymorphisms	polymorphism	NOUN
ajst-32574	42	31	(	(	PUNCT
ajst-32574	42	32	snps	snps	PROPN
ajst-32574	42	33	)	)	PUNCT
ajst-32574	42	34	that	that	PRON
ajst-32574	42	35	relate	relate	VERB
ajst-32574	42	36	to	to	ADP
ajst-32574	42	37	25(oh)d	25(oh)d	NUM
ajst-32574	42	38	levels	level	NOUN
ajst-32574	42	39	in	in	ADP
ajst-32574	42	40	a	a	DET
ajst-32574	42	41	large	large	ADJ
ajst-32574	42	42	vitamin	vitamin	NOUN
ajst-32574	42	43	d	d	NOUN
ajst-32574	42	44	genomewide	genomewide	NOUN
ajst-32574	42	45	association	association	NOUN
ajst-32574	42	46	study	study	NOUN
ajst-32574	42	47	.	.	PUNCT
ajst-32574	43	1	durá	durá	NOUN
ajst-32574	43	2	-	-	PUNCT
ajst-32574	43	3	travé	travé	NOUN
ajst-32574	43	4	and	and	CCONJ
ajst-32574	43	5	gallinas	gallina	NOUN
ajst-32574	43	6	-	-	PUNCT
ajst-32574	43	7	victoriano	victoriano	NOUN
ajst-32574	44	1	[	[	X
ajst-32574	44	2	11	11	NUM
ajst-32574	44	3	]	]	PUNCT
ajst-32574	44	4	conducted	conduct	VERB
ajst-32574	44	5	a	a	DET
ajst-32574	44	6	comprehensive	comprehensive	ADJ
ajst-32574	44	7	review	review	NOUN
ajst-32574	44	8	of	of	ADP
ajst-32574	44	9	clinical	clinical	ADJ
ajst-32574	44	10	and	and	CCONJ
ajst-32574	44	11	experimental	experimental	ADJ
ajst-32574	44	12	studies	study	NOUN
ajst-32574	44	13	assessing	assess	VERB
ajst-32574	44	14	vitamin	vitamin	NOUN
ajst-32574	44	15	d	d	NOUN
ajst-32574	44	16	supplementation	supplementation	NOUN
ajst-32574	44	17	in	in	ADP
ajst-32574	44	18	patients	patient	NOUN
ajst-32574	44	19	with	with	ADP
ajst-32574	44	20	t1d	t1d	PROPN
ajst-32574	44	21	.	.	PUNCT
ajst-32574	45	1	they	they	PRON
ajst-32574	45	2	summarized	summarize	VERB
ajst-32574	45	3	data	datum	NOUN
ajst-32574	45	4	from	from	ADP
ajst-32574	45	5	randomized	randomized	ADJ
ajst-32574	45	6	and	and	CCONJ
ajst-32574	45	7	observational	observational	ADJ
ajst-32574	45	8	trials	trial	NOUN
ajst-32574	45	9	,	,	PUNCT
ajst-32574	45	10	showing	show	VERB
ajst-32574	45	11	that	that	SCONJ
ajst-32574	45	12	supplementation	supplementation	NOUN
ajst-32574	45	13	often	often	ADV
ajst-32574	45	14	led	lead	VERB
ajst-32574	45	15	to	to	PART
ajst-32574	45	16	transient	transient	VERB
ajst-32574	45	17	improvements	improvement	NOUN
ajst-32574	45	18	in	in	ADP
ajst-32574	45	19	insulin	insulin	NOUN
ajst-32574	45	20	sensitivity	sensitivity	NOUN
ajst-32574	45	21	or	or	CCONJ
ajst-32574	45	22	hba1c	hba1c	PROPN
ajst-32574	45	23	;	;	PUNCT
ajst-32574	45	24	however	however	ADV
ajst-32574	45	25	,	,	PUNCT
ajst-32574	45	26	results	result	NOUN
ajst-32574	45	27	remained	remain	VERB
ajst-32574	45	28	inconsistent	inconsistent	ADJ
ajst-32574	45	29	due	due	ADP
ajst-32574	45	30	to	to	ADP
ajst-32574	45	31	small	small	ADJ
ajst-32574	45	32	sample	sample	NOUN
ajst-32574	45	33	sizes	size	NOUN
ajst-32574	45	34	,	,	PUNCT
ajst-32574	45	35	variable	variable	NOUN
ajst-32574	45	36	dosing	dosing	NOUN
ajst-32574	45	37	,	,	PUNCT
ajst-32574	45	38	and	and	CCONJ
ajst-32574	45	39	heterogeneous	heterogeneous	ADJ
ajst-32574	45	40	study	study	NOUN
ajst-32574	45	41	designs	design	NOUN
ajst-32574	45	42	.	.	PUNCT
ajst-32574	46	1	therefore	therefore	ADV
ajst-32574	46	2	,	,	PUNCT
ajst-32574	46	3	although	although	SCONJ
ajst-32574	46	4	vitamin	vitamin	NOUN
ajst-32574	46	5	d	d	NOUN
ajst-32574	46	6	deficiency	deficiency	NOUN
ajst-32574	46	7	is	be	AUX
ajst-32574	46	8	prevalent	prevalent	ADJ
ajst-32574	46	9	among	among	ADP
ajst-32574	46	10	individuals	individual	NOUN
ajst-32574	46	11	with	with	ADP
ajst-32574	46	12	t1d	t1d	PROPN
ajst-32574	46	13	,	,	PUNCT
ajst-32574	46	14	current	current	ADJ
ajst-32574	46	15	evidence	evidence	NOUN
ajst-32574	46	16	supports	support	VERB
ajst-32574	46	17	an	an	DET
ajst-32574	46	18	epidemiological	epidemiological	ADJ
ajst-32574	46	19	association	association	NOUN
ajst-32574	46	20	rather	rather	ADV
ajst-32574	46	21	than	than	ADP
ajst-32574	46	22	a	a	DET
ajst-32574	46	23	direct	direct	ADJ
ajst-32574	46	24	causal	causal	NOUN
ajst-32574	46	25	relationship	relationship	NOUN
ajst-32574	46	26	between	between	ADP
ajst-32574	46	27	vitamin	vitamin	NOUN
ajst-32574	46	28	d	d	NOUN
ajst-32574	46	29	status	status	NOUN
ajst-32574	46	30	and	and	CCONJ
ajst-32574	46	31	disease	disease	NOUN
ajst-32574	46	32	onset	onset	VERB
ajst-32574	46	33	.	.	PUNCT
ajst-32574	47	1	while	while	SCONJ
ajst-32574	47	2	epidemiological	epidemiological	ADJ
ajst-32574	47	3	studies	study	NOUN
ajst-32574	47	4	provide	provide	VERB
ajst-32574	47	5	important	important	ADJ
ajst-32574	47	6	clues	clue	NOUN
ajst-32574	47	7	,	,	PUNCT
ajst-32574	47	8	understanding	understand	VERB
ajst-32574	47	9	the	the	DET
ajst-32574	47	10	biological	biological	ADJ
ajst-32574	47	11	mechanisms	mechanism	NOUN
ajst-32574	47	12	by	by	ADP
ajst-32574	47	13	which	which	PRON
ajst-32574	47	14	vitamin	vitamin	NOUN
ajst-32574	47	15	d	d	NOUN
ajst-32574	47	16	influences	influence	VERB
ajst-32574	47	17	t1d	t1d	PROPN
ajst-32574	47	18	pathogenesis	pathogenesis	NOUN
ajst-32574	47	19	is	be	AUX
ajst-32574	47	20	critical	critical	ADJ
ajst-32574	47	21	for	for	ADP
ajst-32574	47	22	developing	develop	VERB
ajst-32574	47	23	targeted	target	VERB
ajst-32574	47	24	interventions	intervention	NOUN
ajst-32574	47	25	.	.	PUNCT
ajst-32574	48	1	several	several	ADJ
ajst-32574	48	2	lines	line	NOUN
ajst-32574	48	3	of	of	ADP
ajst-32574	48	4	evidence	evidence	NOUN
ajst-32574	48	5	have	have	AUX
ajst-32574	48	6	elucidated	elucidate	VERB
ajst-32574	48	7	potential	potential	ADJ
ajst-32574	48	8	immunological	immunological	ADJ
ajst-32574	48	9	and	and	CCONJ
ajst-32574	48	10	molecular	molecular	ADJ
ajst-32574	48	11	pathways	pathway	NOUN
ajst-32574	48	12	.	.	PUNCT
ajst-32574	49	1	at	at	ADP
ajst-32574	49	2	the	the	DET
ajst-32574	49	3	cellular	cellular	ADJ
ajst-32574	49	4	immune	immune	ADJ
ajst-32574	49	5	level	level	NOUN
ajst-32574	49	6	,	,	PUNCT
ajst-32574	49	7	he	he	PRON
ajst-32574	49	8	et	et	VERB
ajst-32574	49	9	al	al	PROPN
ajst-32574	49	10	.	.	PUNCT
ajst-32574	50	1	[	[	X
ajst-32574	50	2	12	12	NUM
ajst-32574	50	3	]	]	PUNCT
ajst-32574	50	4	proposed	propose	VERB
ajst-32574	50	5	that	that	SCONJ
ajst-32574	50	6	vitamin	vitamin	NOUN
ajst-32574	50	7	d	d	NOUN
ajst-32574	50	8	may	may	AUX
ajst-32574	50	9	attenuate	attenuate	VERB
ajst-32574	50	10	inflammation	inflammation	NOUN
ajst-32574	50	11	and	and	CCONJ
ajst-32574	50	12	oxidative	oxidative	ADJ
ajst-32574	50	13	stress	stress	NOUN
ajst-32574	50	14	by	by	ADP
ajst-32574	50	15	downregulating	downregulating	NOUN
ajst-32574	50	16	cathepsin	cathepsin	NOUN
ajst-32574	50	17	g	g	PROPN
ajst-32574	50	18	(	(	PUNCT
ajst-32574	50	19	catg	catg	PROPN
ajst-32574	50	20	)	)	PUNCT
ajst-32574	50	21	,	,	PUNCT
ajst-32574	50	22	thereby	thereby	ADV
ajst-32574	50	23	reducing	reduce	VERB
ajst-32574	50	24	cd4⁺	cd4⁺	ADJ
ajst-32574	50	25	t	t	NOUN
ajst-32574	50	26	-	-	PUNCT
ajst-32574	50	27	cell	cell	NOUN
ajst-32574	50	28	activation	activation	NOUN
ajst-32574	50	29	and	and	CCONJ
ajst-32574	50	30	promoting	promote	VERB
ajst-32574	50	31	a	a	DET
ajst-32574	50	32	shift	shift	NOUN
ajst-32574	50	33	towards	towards	ADP
ajst-32574	50	34	th2	th2	PROPN
ajst-32574	50	35	/	/	SYM
ajst-32574	50	36	treg	treg	PROPN
ajst-32574	50	37	responses	response	NOUN
ajst-32574	50	38	while	while	SCONJ
ajst-32574	50	39	suppressing	suppress	VERB
ajst-32574	50	40	th1	th1	PROPN
ajst-32574	50	41	/	/	SYM
ajst-32574	50	42	th17	th17	NOUN
ajst-32574	50	43	activity	activity	NOUN
ajst-32574	50	44	,	,	PUNCT
ajst-32574	50	45	ultimately	ultimately	ADV
ajst-32574	50	46	protecting	protect	VERB
ajst-32574	50	47	pancreatic	pancreatic	ADJ
ajst-32574	50	48	β	β	NOUN
ajst-32574	50	49	-	-	NOUN
ajst-32574	50	50	cell	cell	NOUN
ajst-32574	50	51	integrity	integrity	NOUN
ajst-32574	50	52	and	and	CCONJ
ajst-32574	50	53	intervening	intervene	VERB
ajst-32574	50	54	in	in	ADP
ajst-32574	50	55	the	the	DET
ajst-32574	50	56	occurrence	occurrence	NOUN
ajst-32574	50	57	of	of	ADP
ajst-32574	50	58	type	type	NOUN
ajst-32574	50	59	i	i	PRON
ajst-32574	50	60	diabetes	diabete	VERB
ajst-32574	50	61	.	.	PUNCT
ajst-32574	51	1	at	at	ADP
ajst-32574	51	2	the	the	DET
ajst-32574	51	3	epigenetic	epigenetic	ADJ
ajst-32574	51	4	level	level	NOUN
ajst-32574	51	5	,	,	PUNCT
ajst-32574	51	6	mazur	mazur	PROPN
ajst-32574	51	7	et	et	PROPN
ajst-32574	51	8	al	al	PROPN
ajst-32574	51	9	.	.	PUNCT
ajst-32574	52	1	[	[	X
ajst-32574	52	2	13	13	NUM
ajst-32574	52	3	]	]	PUNCT
ajst-32574	52	4	reviewed	review	VERB
ajst-32574	52	5	vitamin	vitamin	NOUN
ajst-32574	52	6	d	d	NOUN
ajst-32574	52	7	as	as	ADP
ajst-32574	52	8	a	a	DET
ajst-32574	52	9	nutri	nutri	ADJ
ajst-32574	52	10	-	-	PUNCT
ajst-32574	52	11	epigenetic	epigenetic	ADJ
ajst-32574	52	12	factor	factor	NOUN
ajst-32574	52	13	,	,	PUNCT
ajst-32574	52	14	capable	capable	ADJ
ajst-32574	52	15	of	of	ADP
ajst-32574	52	16	shaping	shape	VERB
ajst-32574	52	17	immune	immune	ADJ
ajst-32574	52	18	tolerance	tolerance	NOUN
ajst-32574	52	19	and	and	CCONJ
ajst-32574	52	20	inflammatory	inflammatory	ADJ
ajst-32574	52	21	networks	network	NOUN
ajst-32574	52	22	through	through	ADP
ajst-32574	52	23	dna	dna	PROPN
ajst-32574	52	24	methylation	methylation	NOUN
ajst-32574	52	25	,	,	PUNCT
ajst-32574	52	26	histone	histone	NOUN
ajst-32574	52	27	modifications	modification	NOUN
ajst-32574	52	28	,	,	PUNCT
ajst-32574	52	29	and	and	CCONJ
ajst-32574	52	30	regulation	regulation	NOUN
ajst-32574	52	31	of	of	ADP
ajst-32574	52	32	non	non	ADJ
ajst-32574	52	33	-	-	ADJ
ajst-32574	52	34	coding	coding	ADJ
ajst-32574	52	35	rnas	rna	NOUN
ajst-32574	52	36	(	(	PUNCT
ajst-32574	52	37	mirnas	mirna	NOUN
ajst-32574	52	38	and	and	CCONJ
ajst-32574	52	39	lncrnas	lncrna	NOUN
ajst-32574	52	40	)	)	PUNCT
ajst-32574	52	41	.	.	PUNCT
ajst-32574	53	1	moreover	moreover	ADV
ajst-32574	53	2	,	,	PUNCT
ajst-32574	53	3	cristelo	cristelo	NOUN
ajst-32574	53	4	et	et	PROPN
ajst-32574	53	5	al	al	PROPN
ajst-32574	53	6	.	.	PUNCT
ajst-32574	54	1	[	[	X
ajst-32574	54	2	14	14	NUM
ajst-32574	54	3	]	]	PUNCT
ajst-32574	54	4	explored	explore	VERB
ajst-32574	54	5	the	the	DET
ajst-32574	54	6	role	role	NOUN
ajst-32574	54	7	of	of	ADP
ajst-32574	54	8	cathelicidin	cathelicidin	VERB
ajst-32574	54	9	expression	expression	NOUN
ajst-32574	54	10	in	in	ADP
ajst-32574	54	11	t1d	t1d	PROPN
ajst-32574	54	12	susceptibility	susceptibility	NOUN
ajst-32574	54	13	.	.	PUNCT
ajst-32574	55	1	on	on	ADP
ajst-32574	55	2	promoting	promote	VERB
ajst-32574	55	3	inflammation	inflammation	NOUN
ajst-32574	55	4	,	,	PUNCT
ajst-32574	55	5	β	β	NOUN
ajst-32574	55	6	-	-	NOUN
ajst-32574	55	7	cell	cell	NOUN
ajst-32574	55	8	injury	injury	NOUN
ajst-32574	55	9	can	can	AUX
ajst-32574	55	10	release	release	VERB
ajst-32574	55	11	self	self	NOUN
ajst-32574	55	12	-	-	PUNCT
ajst-32574	55	13	dna	dna	NOUN
ajst-32574	55	14	,	,	PUNCT
ajst-32574	55	15	which	which	PRON
ajst-32574	55	16	complexes	complexe	VERB
ajst-32574	55	17	with	with	ADP
ajst-32574	55	18	cathelicidin	cathelicidin	VERB
ajst-32574	55	19	to	to	PART
ajst-32574	55	20	activate	activate	VERB
ajst-32574	55	21	toll	toll	NOUN
ajst-32574	55	22	-	-	PUNCT
ajst-32574	55	23	like	like	ADJ
ajst-32574	55	24	receptor	receptor	NOUN
ajst-32574	55	25	9	9	NUM
ajst-32574	55	26	(	(	PUNCT
ajst-32574	55	27	tlr9	tlr9	NOUN
ajst-32574	55	28	)	)	PUNCT
ajst-32574	55	29	in	in	ADP
ajst-32574	55	30	macrophages	macrophage	NOUN
ajst-32574	55	31	and	and	CCONJ
ajst-32574	55	32	dendritic	dendritic	ADJ
ajst-32574	55	33	cells	cell	NOUN
ajst-32574	55	34	,	,	PUNCT
ajst-32574	55	35	triggering	trigger	VERB
ajst-32574	55	36	ifn	ifn	PROPN
ajst-32574	55	37	-	-	PUNCT
ajst-32574	55	38	α	α	NOUN
ajst-32574	55	39	production	production	NOUN
ajst-32574	55	40	and	and	CCONJ
ajst-32574	55	41	amplifying	amplifying	ADJ
ajst-32574	55	42	inflammation	inflammation	NOUN
ajst-32574	55	43	.	.	PUNCT
ajst-32574	56	1	on	on	ADP
ajst-32574	56	2	the	the	DET
ajst-32574	56	3	protective	protective	ADJ
ajst-32574	56	4	side	side	NOUN
ajst-32574	56	5	,	,	PUNCT
ajst-32574	56	6	cathelicidin	cathelicidin	NOUN
ajst-32574	56	7	,	,	PUNCT
ajst-32574	56	8	induced	induce	VERB
ajst-32574	56	9	by	by	ADP
ajst-32574	56	10	vitamin	vitamin	NOUN
ajst-32574	56	11	d	d	PROPN
ajst-32574	56	12	,	,	PUNCT
ajst-32574	56	13	supports	support	VERB
ajst-32574	56	14	gut	gut	NOUN
ajst-32574	56	15	barrier	barrier	NOUN
ajst-32574	56	16	integrity	integrity	NOUN
ajst-32574	56	17	,	,	PUNCT
ajst-32574	56	18	maintains	maintain	VERB
ajst-32574	56	19	207	207	NUM
ajst-32574	56	20	microbiota	microbiota	NOUN
ajst-32574	56	21	homeostasis	homeostasis	NOUN
ajst-32574	56	22	,	,	PUNCT
ajst-32574	56	23	and	and	CCONJ
ajst-32574	56	24	modulates	modulate	NOUN
ajst-32574	56	25	immune	immune	ADJ
ajst-32574	56	26	responses	response	NOUN
ajst-32574	56	27	,	,	PUNCT
ajst-32574	56	28	collectively	collectively	ADV
ajst-32574	56	29	contributing	contribute	VERB
ajst-32574	56	30	to	to	ADP
ajst-32574	56	31	β	β	NOUN
ajst-32574	56	32	-	-	NOUN
ajst-32574	56	33	cell	cell	NOUN
ajst-32574	56	34	preservation	preservation	NOUN
ajst-32574	56	35	.	.	PUNCT
ajst-32574	57	1	these	these	DET
ajst-32574	57	2	mechanistic	mechanistic	ADJ
ajst-32574	57	3	findings	finding	NOUN
ajst-32574	57	4	highlight	highlight	VERB
ajst-32574	57	5	that	that	PRON
ajst-32574	57	6	vitamin	vitamin	NOUN
ajst-32574	57	7	d	d	NOUN
ajst-32574	57	8	’s	’s	PART
ajst-32574	57	9	role	role	NOUN
ajst-32574	57	10	in	in	ADP
ajst-32574	57	11	t1d	t1d	PROPN
ajst-32574	57	12	extends	extend	VERB
ajst-32574	57	13	beyond	beyond	ADP
ajst-32574	57	14	statistical	statistical	ADJ
ajst-32574	57	15	associations	association	NOUN
ajst-32574	57	16	.	.	PUNCT
ajst-32574	58	1	current	current	ADJ
ajst-32574	58	2	evidence	evidence	NOUN
ajst-32574	58	3	supports	support	VERB
ajst-32574	58	4	a	a	DET
ajst-32574	58	5	modulatory	modulatory	NOUN
ajst-32574	58	6	rather	rather	ADV
ajst-32574	58	7	than	than	ADP
ajst-32574	58	8	a	a	DET
ajst-32574	58	9	causal	causal	ADJ
ajst-32574	58	10	role	role	NOUN
ajst-32574	58	11	for	for	ADP
ajst-32574	58	12	vitamin	vitamin	NOUN
ajst-32574	58	13	d	d	NOUN
ajst-32574	58	14	,	,	PUNCT
ajst-32574	58	15	primarily	primarily	ADV
ajst-32574	58	16	through	through	ADP
ajst-32574	58	17	its	its	PRON
ajst-32574	58	18	influence	influence	NOUN
ajst-32574	58	19	on	on	ADP
ajst-32574	58	20	immune	immune	ADJ
ajst-32574	58	21	and	and	CCONJ
ajst-32574	58	22	epigenetic	epigenetic	ADJ
ajst-32574	58	23	regulatory	regulatory	ADJ
ajst-32574	58	24	pathways	pathway	NOUN
ajst-32574	58	25	.	.	PUNCT
ajst-32574	59	1	rather	rather	ADV
ajst-32574	59	2	than	than	ADP
ajst-32574	59	3	focusing	focus	VERB
ajst-32574	59	4	solely	solely	ADV
ajst-32574	59	5	on	on	ADP
ajst-32574	59	6	whether	whether	SCONJ
ajst-32574	59	7	vitamin	vitamin	NOUN
ajst-32574	59	8	d	d	NOUN
ajst-32574	59	9	deficiency	deficiency	NOUN
ajst-32574	59	10	directly	directly	ADV
ajst-32574	59	11	causes	cause	VERB
ajst-32574	59	12	t1d	t1d	PROPN
ajst-32574	59	13	,	,	PUNCT
ajst-32574	59	14	future	future	ADJ
ajst-32574	59	15	research	research	NOUN
ajst-32574	59	16	should	should	AUX
ajst-32574	59	17	pay	pay	VERB
ajst-32574	59	18	more	more	ADJ
ajst-32574	59	19	attention	attention	NOUN
ajst-32574	59	20	on	on	ADP
ajst-32574	59	21	elucidating	elucidate	VERB
ajst-32574	59	22	the	the	DET
ajst-32574	59	23	underlying	underlying	ADJ
ajst-32574	59	24	epigenetic	epigenetic	ADJ
ajst-32574	59	25	mechanisms	mechanism	NOUN
ajst-32574	59	26	that	that	PRON
ajst-32574	59	27	mediate	mediate	VERB
ajst-32574	59	28	its	its	PRON
ajst-32574	59	29	immunomodulatory	immunomodulatory	ADJ
ajst-32574	59	30	effects	effect	NOUN
ajst-32574	59	31	.	.	PUNCT
ajst-32574	60	1	such	such	DET
ajst-32574	60	2	an	an	DET
ajst-32574	60	3	approach	approach	NOUN
ajst-32574	60	4	may	may	AUX
ajst-32574	60	5	provide	provide	VERB
ajst-32574	60	6	a	a	DET
ajst-32574	60	7	more	more	ADV
ajst-32574	60	8	comprehensive	comprehensive	ADJ
ajst-32574	60	9	framework	framework	NOUN
ajst-32574	60	10	for	for	ADP
ajst-32574	60	11	understanding	understand	VERB
ajst-32574	60	12	the	the	DET
ajst-32574	60	13	disease	disease	NOUN
ajst-32574	60	14	mechanism	mechanism	NOUN
ajst-32574	60	15	and	and	CCONJ
ajst-32574	60	16	identifying	identify	VERB
ajst-32574	60	17	new	new	ADJ
ajst-32574	60	18	insights	insight	NOUN
ajst-32574	60	19	and	and	CCONJ
ajst-32574	60	20	strategies	strategy	NOUN
ajst-32574	60	21	.	.	PUNCT
ajst-32574	61	1	2.2	2.2	NUM
ajst-32574	61	2	enterovirus	enterovirus	NOUN
ajst-32574	61	3	although	although	SCONJ
ajst-32574	61	4	the	the	DET
ajst-32574	61	5	role	role	NOUN
ajst-32574	61	6	and	and	CCONJ
ajst-32574	61	7	mechanisms	mechanism	NOUN
ajst-32574	61	8	of	of	ADP
ajst-32574	61	9	vitamin	vitamin	NOUN
ajst-32574	61	10	d	d	NOUN
ajst-32574	61	11	in	in	ADP
ajst-32574	61	12	type	type	NOUN
ajst-32574	61	13	1	1	NUM
ajst-32574	61	14	diabetes	diabetes	NOUN
ajst-32574	61	15	remain	remain	VERB
ajst-32574	61	16	to	to	PART
ajst-32574	61	17	be	be	AUX
ajst-32574	61	18	clarified	clarify	VERB
ajst-32574	61	19	,	,	PUNCT
ajst-32574	61	20	enteroviruses	enterovirus	NOUN
ajst-32574	61	21	have	have	AUX
ajst-32574	61	22	been	be	AUX
ajst-32574	61	23	more	more	ADV
ajst-32574	61	24	consistently	consistently	ADV
ajst-32574	61	25	implicated	implicate	VERB
ajst-32574	61	26	as	as	ADP
ajst-32574	61	27	candidates	candidate	NOUN
ajst-32574	61	28	for	for	ADP
ajst-32574	61	29	initiating	initiate	VERB
ajst-32574	61	30	islet	islet	NOUN
ajst-32574	61	31	autoimmunity	autoimmunity	NOUN
ajst-32574	61	32	and	and	CCONJ
ajst-32574	61	33	leading	lead	VERB
ajst-32574	61	34	to	to	ADP
ajst-32574	61	35	t1d	t1d	PROPN
ajst-32574	61	36	.	.	PUNCT
ajst-32574	62	1	as	as	SCONJ
ajst-32574	62	2	highlighted	highlight	VERB
ajst-32574	62	3	by	by	ADP
ajst-32574	62	4	hyöty	hyöty	PROPN
ajst-32574	62	5	et	et	PROPN
ajst-32574	62	6	al	al	PROPN
ajst-32574	62	7	.	.	PUNCT
ajst-32574	63	1	[	[	X
ajst-32574	63	2	15	15	NUM
ajst-32574	63	3	]	]	PUNCT
ajst-32574	63	4	,	,	PUNCT
ajst-32574	63	5	evs	evs	AUX
ajst-32574	63	6	stand	stand	VERB
ajst-32574	63	7	out	out	ADP
ajst-32574	63	8	among	among	ADP
ajst-32574	63	9	environmental	environmental	ADJ
ajst-32574	63	10	triggers	trigger	NOUN
ajst-32574	63	11	due	due	ADP
ajst-32574	63	12	to	to	ADP
ajst-32574	63	13	the	the	DET
ajst-32574	63	14	large	large	ADJ
ajst-32574	63	15	amount	amount	NOUN
ajst-32574	63	16	of	of	ADP
ajst-32574	63	17	coherent	coherent	ADJ
ajst-32574	63	18	evidence	evidence	NOUN
ajst-32574	63	19	linking	link	VERB
ajst-32574	63	20	them	they	PRON
ajst-32574	63	21	to	to	ADP
ajst-32574	63	22	the	the	DET
ajst-32574	63	23	early	early	ADJ
ajst-32574	63	24	stages	stage	NOUN
ajst-32574	63	25	of	of	ADP
ajst-32574	63	26	autoimmunity	autoimmunity	NOUN
ajst-32574	63	27	.	.	PUNCT
ajst-32574	64	1	epidemiological	epidemiological	ADJ
ajst-32574	64	2	and	and	CCONJ
ajst-32574	64	3	pathological	pathological	ADJ
ajst-32574	64	4	studies	study	NOUN
ajst-32574	64	5	have	have	AUX
ajst-32574	64	6	repeatedly	repeatedly	ADV
ajst-32574	64	7	shown	show	VERB
ajst-32574	64	8	that	that	DET
ajst-32574	64	9	exposure	exposure	NOUN
ajst-32574	64	10	to	to	ADP
ajst-32574	64	11	ev	ev	PROPN
ajst-32574	64	12	is	be	AUX
ajst-32574	64	13	significantly	significantly	ADV
ajst-32574	64	14	associated	associate	VERB
ajst-32574	64	15	with	with	ADP
ajst-32574	64	16	the	the	DET
ajst-32574	64	17	initiation	initiation	NOUN
ajst-32574	64	18	of	of	ADP
ajst-32574	64	19	ia	ia	PROPN
ajst-32574	64	20	and	and	CCONJ
ajst-32574	64	21	clinical	clinical	ADJ
ajst-32574	64	22	t1d	t1d	PROPN
ajst-32574	64	23	,	,	PUNCT
ajst-32574	64	24	making	make	VERB
ajst-32574	64	25	ev	ev	ADP
ajst-32574	64	26	the	the	DET
ajst-32574	64	27	most	most	ADV
ajst-32574	64	28	likely	likely	ADJ
ajst-32574	64	29	environmental	environmental	ADJ
ajst-32574	64	30	trigger	trigger	NOUN
ajst-32574	64	31	of	of	ADP
ajst-32574	64	32	t1d	t1d	PROPN
ajst-32574	64	33	.	.	PUNCT
ajst-32574	65	1	yang	yang	PROPN
ajst-32574	65	2	et	et	PROPN
ajst-32574	65	3	al	al	PROPN
ajst-32574	65	4	.	.	PUNCT
ajst-32574	66	1	[	[	X
ajst-32574	66	2	16	16	NUM
ajst-32574	66	3	]	]	PUNCT
ajst-32574	66	4	conducted	conduct	VERB
ajst-32574	66	5	a	a	DET
ajst-32574	66	6	systematic	systematic	ADJ
ajst-32574	66	7	review	review	NOUN
ajst-32574	66	8	and	and	CCONJ
ajst-32574	66	9	meta	meta	ADJ
ajst-32574	66	10	-	-	PUNCT
ajst-32574	66	11	analysis	analysis	NOUN
ajst-32574	66	12	of	of	ADP
ajst-32574	66	13	25	25	NUM
ajst-32574	66	14	observational	observational	ADJ
ajst-32574	66	15	studies	study	NOUN
ajst-32574	66	16	,	,	PUNCT
ajst-32574	66	17	incorporating	incorporate	VERB
ajst-32574	66	18	different	different	ADJ
ajst-32574	66	19	sample	sample	NOUN
ajst-32574	66	20	sources	source	NOUN
ajst-32574	66	21	,	,	PUNCT
ajst-32574	66	22	such	such	ADJ
ajst-32574	66	23	as	as	ADP
ajst-32574	66	24	pancreas	pancrea	NOUN
ajst-32574	66	25	,	,	PUNCT
ajst-32574	66	26	pbmcs	pbmcs	NOUN
ajst-32574	66	27	,	,	PUNCT
ajst-32574	66	28	serum	serum	NOUN
ajst-32574	66	29	,	,	PUNCT
ajst-32574	66	30	and	and	CCONJ
ajst-32574	66	31	detection	detection	NOUN
ajst-32574	66	32	methods	method	NOUN
ajst-32574	66	33	,	,	PUNCT
ajst-32574	66	34	such	such	ADJ
ajst-32574	66	35	as	as	ADP
ajst-32574	66	36	rt	rt	NOUN
ajst-32574	66	37	-	-	PUNCT
ajst-32574	66	38	pcr	pcr	ADJ
ajst-32574	66	39	,	,	PUNCT
ajst-32574	66	40	immunohistochemistry	immunohistochemistry	NOUN
ajst-32574	66	41	,	,	PUNCT
ajst-32574	66	42	and	and	CCONJ
ajst-32574	66	43	serology	serology	NOUN
ajst-32574	66	44	.	.	PUNCT
ajst-32574	67	1	they	they	PRON
ajst-32574	67	2	reported	report	VERB
ajst-32574	67	3	an	an	DET
ajst-32574	67	4	odds	odd	NOUN
ajst-32574	67	5	ratio	ratio	NOUN
ajst-32574	67	6	of	of	ADP
ajst-32574	67	7	nearly	nearly	ADV
ajst-32574	67	8	6	6	NUM
ajst-32574	67	9	for	for	ADP
ajst-32574	67	10	the	the	DET
ajst-32574	67	11	association	association	NOUN
ajst-32574	67	12	between	between	ADP
ajst-32574	67	13	enterovirus	enterovirus	NOUN
ajst-32574	67	14	infection	infection	NOUN
ajst-32574	67	15	and	and	CCONJ
ajst-32574	67	16	clinical	clinical	ADJ
ajst-32574	67	17	t1d	t1d	PROPN
ajst-32574	67	18	,	,	PUNCT
ajst-32574	67	19	with	with	ADP
ajst-32574	67	20	stronger	strong	ADJ
ajst-32574	67	21	effects	effect	NOUN
ajst-32574	67	22	observed	observe	VERB
ajst-32574	67	23	in	in	ADP
ajst-32574	67	24	pancreatic	pancreatic	ADJ
ajst-32574	67	25	tissue	tissue	NOUN
ajst-32574	67	26	and	and	CCONJ
ajst-32574	67	27	in	in	ADP
ajst-32574	67	28	children	child	NOUN
ajst-32574	67	29	.	.	PUNCT
ajst-32574	68	1	complementarily	complementarily	ADV
ajst-32574	68	2	,	,	PUNCT
ajst-32574	68	3	wang	wang	PROPN
ajst-32574	68	4	et	et	PROPN
ajst-32574	68	5	al	al	PROPN
ajst-32574	68	6	.	.	PUNCT
ajst-32574	69	1	[	[	X
ajst-32574	69	2	17	17	NUM
ajst-32574	69	3	]	]	PUNCT
ajst-32574	69	4	analyzed	analyze	VERB
ajst-32574	69	5	38	38	NUM
ajst-32574	69	6	case	case	NOUN
ajst-32574	69	7	–	–	PUNCT
ajst-32574	69	8	control	control	NOUN
ajst-32574	69	9	studies	study	NOUN
ajst-32574	69	10	and	and	CCONJ
ajst-32574	69	11	confirmed	confirm	VERB
ajst-32574	69	12	this	this	DET
ajst-32574	69	13	relationship	relationship	NOUN
ajst-32574	69	14	across	across	ADP
ajst-32574	69	15	different	different	ADJ
ajst-32574	69	16	geographic	geographic	ADJ
ajst-32574	69	17	regions	region	NOUN
ajst-32574	69	18	,	,	PUNCT
ajst-32574	69	19	including	include	VERB
ajst-32574	69	20	europe	europe	PROPN
ajst-32574	69	21	,	,	PUNCT
ajst-32574	69	22	asia	asia	PROPN
ajst-32574	69	23	,	,	PUNCT
ajst-32574	69	24	africa	africa	PROPN
ajst-32574	69	25	,	,	PUNCT
ajst-32574	69	26	and	and	CCONJ
ajst-32574	69	27	latin	latin	PROPN
ajst-32574	69	28	america	america	PROPN
ajst-32574	69	29	,	,	PUNCT
ajst-32574	69	30	indicating	indicate	VERB
ajst-32574	69	31	that	that	SCONJ
ajst-32574	69	32	the	the	DET
ajst-32574	69	33	link	link	NOUN
ajst-32574	69	34	between	between	ADP
ajst-32574	69	35	ev	ev	ADP
ajst-32574	69	36	infection	infection	NOUN
ajst-32574	69	37	and	and	CCONJ
ajst-32574	69	38	t1d	t1d	PROPN
ajst-32574	69	39	is	be	AUX
ajst-32574	69	40	not	not	PART
ajst-32574	69	41	confined	confine	VERB
ajst-32574	69	42	to	to	ADP
ajst-32574	69	43	specific	specific	ADJ
ajst-32574	69	44	populations	population	NOUN
ajst-32574	69	45	or	or	CCONJ
ajst-32574	69	46	methodologies	methodology	NOUN
ajst-32574	69	47	.	.	PUNCT
ajst-32574	70	1	taken	take	VERB
ajst-32574	70	2	together	together	ADV
ajst-32574	70	3	,	,	PUNCT
ajst-32574	70	4	these	these	DET
ajst-32574	70	5	findings	finding	NOUN
ajst-32574	70	6	indicate	indicate	VERB
ajst-32574	70	7	that	that	SCONJ
ajst-32574	70	8	enterovirus	enterovirus	NOUN
ajst-32574	70	9	infection	infection	NOUN
ajst-32574	70	10	is	be	AUX
ajst-32574	70	11	associated	associate	VERB
ajst-32574	70	12	with	with	ADP
ajst-32574	70	13	an	an	DET
ajst-32574	70	14	increased	increase	VERB
ajst-32574	70	15	risk	risk	NOUN
ajst-32574	70	16	of	of	ADP
ajst-32574	70	17	t1d	t1d	PROPN
ajst-32574	70	18	initiation	initiation	NOUN
ajst-32574	70	19	.	.	PUNCT
ajst-32574	71	1	based	base	VERB
ajst-32574	71	2	on	on	ADP
ajst-32574	71	3	the	the	DET
ajst-32574	71	4	epidemiological	epidemiological	ADJ
ajst-32574	71	5	evidence	evidence	NOUN
ajst-32574	71	6	,	,	PUNCT
ajst-32574	71	7	it	it	PRON
ajst-32574	71	8	is	be	AUX
ajst-32574	71	9	important	important	ADJ
ajst-32574	71	10	to	to	PART
ajst-32574	71	11	consider	consider	VERB
ajst-32574	71	12	how	how	SCONJ
ajst-32574	71	13	viruses	virus	NOUN
ajst-32574	71	14	may	may	AUX
ajst-32574	71	15	contribute	contribute	VERB
ajst-32574	71	16	to	to	ADP
ajst-32574	71	17	the	the	DET
ajst-32574	71	18	development	development	NOUN
ajst-32574	71	19	of	of	ADP
ajst-32574	71	20	type	type	NOUN
ajst-32574	71	21	1	1	NUM
ajst-32574	71	22	diabetes	diabetes	NOUN
ajst-32574	71	23	.	.	PUNCT
ajst-32574	72	1	alves	alves	PROPN
ajst-32574	72	2	abrantes	abrante	NOUN
ajst-32574	72	3	et	et	PROPN
ajst-32574	72	4	al	al	PROPN
ajst-32574	72	5	.	.	PUNCT
ajst-32574	73	1	[	[	X
ajst-32574	73	2	18	18	NUM
ajst-32574	73	3	]	]	PUNCT
ajst-32574	73	4	reported	report	VERB
ajst-32574	73	5	that	that	SCONJ
ajst-32574	73	6	multiple	multiple	ADJ
ajst-32574	73	7	viruses	virus	NOUN
ajst-32574	73	8	have	have	AUX
ajst-32574	73	9	been	be	AUX
ajst-32574	73	10	proposed	propose	VERB
ajst-32574	73	11	as	as	ADP
ajst-32574	73	12	potential	potential	ADJ
ajst-32574	73	13	environmental	environmental	ADJ
ajst-32574	73	14	triggers	trigger	NOUN
ajst-32574	73	15	of	of	ADP
ajst-32574	73	16	t1d	t1d	PROPN
ajst-32574	73	17	,	,	PUNCT
ajst-32574	73	18	and	and	CCONJ
ajst-32574	73	19	enteroviruses	enterovirus	NOUN
ajst-32574	73	20	have	have	AUX
ajst-32574	73	21	received	receive	VERB
ajst-32574	73	22	the	the	DET
ajst-32574	73	23	strongest	strong	ADJ
ajst-32574	73	24	support	support	NOUN
ajst-32574	73	25	.	.	PUNCT
ajst-32574	74	1	these	these	DET
ajst-32574	74	2	agents	agent	NOUN
ajst-32574	74	3	are	be	AUX
ajst-32574	74	4	hypothesized	hypothesize	VERB
ajst-32574	74	5	to	to	PART
ajst-32574	74	6	influence	influence	VERB
ajst-32574	74	7	β	β	NOUN
ajst-32574	74	8	-	-	NOUN
ajst-32574	74	9	cell	cell	NOUN
ajst-32574	74	10	autoimmunity	autoimmunity	NOUN
ajst-32574	74	11	through	through	ADP
ajst-32574	74	12	diverse	diverse	ADJ
ajst-32574	74	13	immunological	immunological	ADJ
ajst-32574	74	14	pathways	pathway	NOUN
ajst-32574	74	15	,	,	PUNCT
ajst-32574	74	16	including	include	VERB
ajst-32574	74	17	molecular	molecular	ADJ
ajst-32574	74	18	mimicry	mimicry	ADJ
ajst-32574	74	19	,	,	PUNCT
ajst-32574	74	20	bystander	bystander	NOUN
ajst-32574	74	21	activation	activation	NOUN
ajst-32574	74	22	,	,	PUNCT
ajst-32574	74	23	and	and	CCONJ
ajst-32574	74	24	persistent	persistent	ADJ
ajst-32574	74	25	lowgrade	lowgrade	NOUN
ajst-32574	74	26	infections	infection	NOUN
ajst-32574	74	27	.	.	PUNCT
ajst-32574	75	1	among	among	ADP
ajst-32574	75	2	them	they	PRON
ajst-32574	75	3	,	,	PUNCT
ajst-32574	75	4	enteroviruses	enterovirus	NOUN
ajst-32574	75	5	have	have	AUX
ajst-32574	75	6	been	be	AUX
ajst-32574	75	7	the	the	DET
ajst-32574	75	8	most	most	ADV
ajst-32574	75	9	extensively	extensively	ADV
ajst-32574	75	10	studied	study	VERB
ajst-32574	75	11	.	.	PUNCT
ajst-32574	76	1	lloyd	lloyd	PROPN
ajst-32574	76	2	et	et	PROPN
ajst-32574	76	3	al	al	PROPN
ajst-32574	76	4	.	.	PUNCT
ajst-32574	77	1	[	[	X
ajst-32574	77	2	19	19	NUM
ajst-32574	77	3	]	]	PUNCT
ajst-32574	77	4	highlighted	highlight	VERB
ajst-32574	77	5	several	several	ADJ
ajst-32574	77	6	non	non	ADJ
ajst-32574	77	7	-	-	ADJ
ajst-32574	77	8	exclusive	exclusive	ADJ
ajst-32574	77	9	mechanisms	mechanism	NOUN
ajst-32574	77	10	by	by	ADP
ajst-32574	77	11	which	which	PRON
ajst-32574	77	12	they	they	PRON
ajst-32574	77	13	could	could	AUX
ajst-32574	77	14	promote	promote	VERB
ajst-32574	77	15	islet	islet	NOUN
ajst-32574	77	16	autoimmunity	autoimmunity	NOUN
ajst-32574	77	17	:	:	PUNCT
ajst-32574	77	18	(	(	PUNCT
ajst-32574	77	19	1	1	X
ajst-32574	77	20	)	)	PUNCT
ajst-32574	77	21	enhanced	enhance	VERB
ajst-32574	77	22	βcell	βcell	NOUN
ajst-32574	77	23	susceptibility	susceptibility	NOUN
ajst-32574	77	24	due	due	ADP
ajst-32574	77	25	to	to	ADP
ajst-32574	77	26	increased	increase	VERB
ajst-32574	77	27	expression	expression	NOUN
ajst-32574	77	28	of	of	ADP
ajst-32574	77	29	the	the	DET
ajst-32574	77	30	coxsackievirus	coxsackievirus	NOUN
ajst-32574	77	31	–	–	PUNCT
ajst-32574	77	32	adenovirus	adenovirus	NOUN
ajst-32574	77	33	receptor	receptor	NOUN
ajst-32574	77	34	;	;	PUNCT
ajst-32574	77	35	(	(	PUNCT
ajst-32574	77	36	2	2	X
ajst-32574	77	37	)	)	PUNCT
ajst-32574	77	38	induction	induction	NOUN
ajst-32574	77	39	of	of	ADP
ajst-32574	77	40	endoplasmic	endoplasmic	ADJ
ajst-32574	77	41	reticulum	reticulum	NOUN
ajst-32574	77	42	stress	stress	NOUN
ajst-32574	77	43	and	and	CCONJ
ajst-32574	77	44	mirna	mirna	PROPN
ajst-32574	77	45	dysregulation	dysregulation	PROPN
ajst-32574	77	46	,	,	PUNCT
ajst-32574	77	47	impairing	impair	VERB
ajst-32574	77	48	β	β	NOUN
ajst-32574	77	49	-	-	NOUN
ajst-32574	77	50	cell	cell	NOUN
ajst-32574	77	51	homeostasis	homeostasis	NOUN
ajst-32574	77	52	;	;	PUNCT
ajst-32574	77	53	(	(	PUNCT
ajst-32574	77	54	3	3	X
ajst-32574	77	55	)	)	PUNCT
ajst-32574	77	56	molecular	molecular	ADJ
ajst-32574	77	57	mimicry	mimicry	NOUN
ajst-32574	77	58	and	and	CCONJ
ajst-32574	77	59	presentation	presentation	NOUN
ajst-32574	77	60	of	of	ADP
ajst-32574	77	61	defective	defective	ADJ
ajst-32574	77	62	ribosomal	ribosomal	NOUN
ajst-32574	77	63	products	product	NOUN
ajst-32574	77	64	,	,	PUNCT
ajst-32574	77	65	fueling	fuel	VERB
ajst-32574	77	66	cross	cross	ADJ
ajst-32574	77	67	-	-	ADJ
ajst-32574	77	68	reactive	reactive	ADJ
ajst-32574	77	69	t	t	NOUN
ajst-32574	77	70	-	-	PUNCT
ajst-32574	77	71	cell	cell	NOUN
ajst-32574	77	72	responses	response	NOUN
ajst-32574	77	73	;	;	PUNCT
ajst-32574	77	74	(	(	PUNCT
ajst-32574	77	75	4	4	X
ajst-32574	77	76	)	)	PUNCT
ajst-32574	77	77	cytokine	cytokine	NOUN
ajst-32574	77	78	-	-	PUNCT
ajst-32574	77	79	mediated	mediate	VERB
ajst-32574	77	80	bystander	bystander	NOUN
ajst-32574	77	81	damage	damage	NOUN
ajst-32574	77	82	amplifying	amplify	VERB
ajst-32574	77	83	local	local	ADJ
ajst-32574	77	84	inflammation	inflammation	NOUN
ajst-32574	77	85	.	.	PUNCT
ajst-32574	78	1	these	these	DET
ajst-32574	78	2	mechanisms	mechanism	NOUN
ajst-32574	78	3	provide	provide	VERB
ajst-32574	78	4	a	a	DET
ajst-32574	78	5	plausible	plausible	ADJ
ajst-32574	78	6	framework	framework	NOUN
ajst-32574	78	7	for	for	ADP
ajst-32574	78	8	linking	link	VERB
ajst-32574	78	9	viral	viral	ADJ
ajst-32574	78	10	infections	infection	NOUN
ajst-32574	78	11	to	to	ADP
ajst-32574	78	12	β	β	NOUN
ajst-32574	78	13	-	-	NOUN
ajst-32574	78	14	cell	cell	NOUN
ajst-32574	78	15	loss	loss	NOUN
ajst-32574	78	16	and	and	CCONJ
ajst-32574	78	17	t1d	t1d	PROPN
ajst-32574	78	18	onset	onset	NOUN
ajst-32574	78	19	.	.	PUNCT
ajst-32574	79	1	building	build	VERB
ajst-32574	79	2	on	on	ADP
ajst-32574	79	3	these	these	DET
ajst-32574	79	4	mechanisms	mechanism	NOUN
ajst-32574	79	5	,	,	PUNCT
ajst-32574	79	6	recent	recent	ADJ
ajst-32574	79	7	findings	finding	NOUN
ajst-32574	79	8	indicate	indicate	VERB
ajst-32574	79	9	that	that	DET
ajst-32574	79	10	mirna	mirna	PROPN
ajst-32574	79	11	dysregulation	dysregulation	NOUN
ajst-32574	79	12	itself	itself	PRON
ajst-32574	79	13	can	can	AUX
ajst-32574	79	14	serve	serve	VERB
ajst-32574	79	15	as	as	ADP
ajst-32574	79	16	an	an	DET
ajst-32574	79	17	epigenetic	epigenetic	ADJ
ajst-32574	79	18	mechanism	mechanism	NOUN
ajst-32574	79	19	to	to	PART
ajst-32574	79	20	explain	explain	VERB
ajst-32574	79	21	the	the	DET
ajst-32574	79	22	β	β	NOUN
ajst-32574	79	23	-	-	NOUN
ajst-32574	79	24	cell	cell	NOUN
ajst-32574	79	25	destruction	destruction	NOUN
ajst-32574	79	26	.	.	PUNCT
ajst-32574	80	1	yu	yu	PROPN
ajst-32574	80	2	et	et	PROPN
ajst-32574	80	3	al	al	PROPN
ajst-32574	80	4	.	.	PUNCT
ajst-32574	81	1	[	[	X
ajst-32574	81	2	20	20	NUM
ajst-32574	81	3	]	]	PUNCT
ajst-32574	81	4	demonstrated	demonstrate	VERB
ajst-32574	81	5	that	that	SCONJ
ajst-32574	81	6	extracellular	extracellular	ADJ
ajst-32574	81	7	vesicles	vesicle	NOUN
ajst-32574	81	8	released	release	VERB
ajst-32574	81	9	from	from	ADP
ajst-32574	81	10	immune	immune	ADJ
ajst-32574	81	11	cells	cell	NOUN
ajst-32574	81	12	carry	carry	VERB
ajst-32574	81	13	specific	specific	ADJ
ajst-32574	81	14	mirnas	mirna	NOUN
ajst-32574	81	15	,	,	PUNCT
ajst-32574	81	16	such	such	ADJ
ajst-32574	81	17	as	as	ADP
ajst-32574	81	18	mir-142	mir-142	NOUN
ajst-32574	81	19	-	-	PUNCT
ajst-32574	81	20	3p	3p	NUM
ajst-32574	81	21	and	and	CCONJ
ajst-32574	81	22	mir-155	mir-155	NOUN
ajst-32574	81	23	,	,	PUNCT
ajst-32574	81	24	that	that	PRON
ajst-32574	81	25	are	be	AUX
ajst-32574	81	26	taken	take	VERB
ajst-32574	81	27	up	up	ADP
ajst-32574	81	28	by	by	ADP
ajst-32574	81	29	pancreatic	pancreatic	ADJ
ajst-32574	81	30	β	β	NOUN
ajst-32574	81	31	cells	cell	NOUN
ajst-32574	81	32	,	,	PUNCT
ajst-32574	81	33	where	where	SCONJ
ajst-32574	81	34	they	they	PRON
ajst-32574	81	35	suppress	suppress	VERB
ajst-32574	81	36	antiapoptotic	antiapoptotic	ADJ
ajst-32574	81	37	genes	gene	NOUN
ajst-32574	81	38	and	and	CCONJ
ajst-32574	81	39	activate	activate	VERB
ajst-32574	81	40	pro	pro	ADJ
ajst-32574	81	41	-	-	ADJ
ajst-32574	81	42	inflammatory	inflammatory	ADJ
ajst-32574	81	43	signaling	signal	VERB
ajst-32574	81	44	cascades	cascade	NOUN
ajst-32574	81	45	.	.	PUNCT
ajst-32574	82	1	these	these	DET
ajst-32574	82	2	changes	change	NOUN
ajst-32574	82	3	lead	lead	VERB
ajst-32574	82	4	to	to	ADP
ajst-32574	82	5	mitochondrial	mitochondrial	ADJ
ajst-32574	82	6	dysfunction	dysfunction	NOUN
ajst-32574	82	7	and	and	CCONJ
ajst-32574	82	8	apoptotic	apoptotic	ADJ
ajst-32574	82	9	β	β	NOUN
ajst-32574	82	10	-	-	NOUN
ajst-32574	82	11	cell	cell	NOUN
ajst-32574	82	12	loss	loss	NOUN
ajst-32574	82	13	,	,	PUNCT
ajst-32574	82	14	indicating	indicate	VERB
ajst-32574	82	15	an	an	DET
ajst-32574	82	16	epigenetic	epigenetic	ADJ
ajst-32574	82	17	way	way	NOUN
ajst-32574	82	18	to	to	PART
ajst-32574	82	19	explain	explain	VERB
ajst-32574	82	20	how	how	SCONJ
ajst-32574	82	21	viral	viral	ADJ
ajst-32574	82	22	-	-	PUNCT
ajst-32574	82	23	induced	induced	ADJ
ajst-32574	82	24	immune	immune	ADJ
ajst-32574	82	25	activation	activation	NOUN
ajst-32574	82	26	can	can	AUX
ajst-32574	82	27	cause	cause	VERB
ajst-32574	82	28	the	the	DET
ajst-32574	82	29	spread	spread	NOUN
ajst-32574	82	30	of	of	ADP
ajst-32574	82	31	impaired	impaired	ADJ
ajst-32574	82	32	β	β	NOUN
ajst-32574	82	33	-	-	NOUN
ajst-32574	82	34	cell	cell	NOUN
ajst-32574	82	35	through	through	ADP
ajst-32574	82	36	mirna	mirna	NOUN
ajst-32574	82	37	transfer	transfer	NOUN
ajst-32574	82	38	.	.	PUNCT
ajst-32574	83	1	this	this	DET
ajst-32574	83	2	evidence	evidence	NOUN
ajst-32574	83	3	supports	support	VERB
ajst-32574	83	4	the	the	DET
ajst-32574	83	5	view	view	NOUN
ajst-32574	83	6	that	that	SCONJ
ajst-32574	83	7	ev	ev	DET
ajst-32574	83	8	infection	infection	NOUN
ajst-32574	83	9	may	may	AUX
ajst-32574	83	10	influence	influence	VERB
ajst-32574	83	11	t1d	t1d	ADJ
ajst-32574	83	12	pathogenesis	pathogenesis	NOUN
ajst-32574	83	13	not	not	PART
ajst-32574	83	14	only	only	ADV
ajst-32574	83	15	through	through	ADP
ajst-32574	83	16	immune	immune	NOUN
ajst-32574	83	17	-	-	PUNCT
ajst-32574	83	18	mediated	mediate	VERB
ajst-32574	83	19	injury	injury	NOUN
ajst-32574	83	20	but	but	CCONJ
ajst-32574	83	21	also	also	ADV
ajst-32574	83	22	via	via	ADP
ajst-32574	83	23	stable	stable	ADJ
ajst-32574	83	24	epigenetic	epigenetic	ADJ
ajst-32574	83	25	influence	influence	NOUN
ajst-32574	83	26	on	on	ADP
ajst-32574	83	27	β	β	NOUN
ajst-32574	83	28	-	-	NOUN
ajst-32574	83	29	cell	cell	NOUN
ajst-32574	83	30	gene	gene	NOUN
ajst-32574	83	31	expression	expression	NOUN
ajst-32574	83	32	.	.	PUNCT
ajst-32574	84	1	direct	direct	ADJ
ajst-32574	84	2	histopathological	histopathological	ADJ
ajst-32574	84	3	evidence	evidence	NOUN
ajst-32574	84	4	further	far	ADV
ajst-32574	84	5	strengthens	strengthen	VERB
ajst-32574	84	6	this	this	DET
ajst-32574	84	7	model	model	NOUN
ajst-32574	84	8	.	.	PUNCT
ajst-32574	85	1	rodriguez	rodriguez	NOUN
ajst-32574	85	2	-	-	PUNCT
ajst-32574	85	3	calvo	calvo	PROPN
ajst-32574	85	4	et	et	PROPN
ajst-32574	85	5	al	al	PROPN
ajst-32574	85	6	.	.	PUNCT
ajst-32574	86	1	[	[	X
ajst-32574	86	2	21	21	NUM
ajst-32574	86	3	]	]	PUNCT
ajst-32574	86	4	reported	report	VERB
ajst-32574	86	5	the	the	DET
ajst-32574	86	6	detection	detection	NOUN
ajst-32574	86	7	of	of	ADP
ajst-32574	86	8	enteroviral	enteroviral	ADJ
ajst-32574	86	9	vp1	vp1	NOUN
ajst-32574	86	10	protein	protein	NOUN
ajst-32574	86	11	in	in	ADP
ajst-32574	86	12	pancreatic	pancreatic	ADJ
ajst-32574	86	13	islets	islet	NOUN
ajst-32574	86	14	of	of	ADP
ajst-32574	86	15	t1d	t1d	ADJ
ajst-32574	86	16	organ	organ	NOUN
ajst-32574	86	17	donors	donor	NOUN
ajst-32574	86	18	,	,	PUNCT
ajst-32574	86	19	frequently	frequently	ADV
ajst-32574	86	20	accompanied	accompany	VERB
ajst-32574	86	21	by	by	ADP
ajst-32574	86	22	hla	hla	PROPN
ajst-32574	86	23	class	class	NOUN
ajst-32574	86	24	i	i	PROPN
ajst-32574	86	25	hyperexpression	hyperexpression	NOUN
ajst-32574	86	26	,	,	PUNCT
ajst-32574	86	27	which	which	PRON
ajst-32574	86	28	supports	support	VERB
ajst-32574	86	29	the	the	DET
ajst-32574	86	30	concept	concept	NOUN
ajst-32574	86	31	of	of	ADP
ajst-32574	86	32	a	a	DET
ajst-32574	86	33	persistent	persistent	ADJ
ajst-32574	86	34	viral	viral	ADJ
ajst-32574	86	35	208	208	NUM
ajst-32574	86	36	presence	presence	NOUN
ajst-32574	86	37	shaping	shape	VERB
ajst-32574	86	38	local	local	ADJ
ajst-32574	86	39	immune	immune	ADJ
ajst-32574	86	40	activation	activation	NOUN
ajst-32574	86	41	.	.	PUNCT
ajst-32574	87	1	complementary	complementary	ADJ
ajst-32574	87	2	studies	study	NOUN
ajst-32574	87	3	have	have	AUX
ajst-32574	87	4	also	also	ADV
ajst-32574	87	5	demonstrated	demonstrate	VERB
ajst-32574	87	6	the	the	DET
ajst-32574	87	7	presence	presence	NOUN
ajst-32574	87	8	of	of	ADP
ajst-32574	87	9	enteroviral	enteroviral	ADJ
ajst-32574	87	10	rna	rna	NOUN
ajst-32574	87	11	in	in	ADP
ajst-32574	87	12	the	the	DET
ajst-32574	87	13	pancreas	pancrea	NOUN
ajst-32574	87	14	and	and	CCONJ
ajst-32574	87	15	lymphoid	lymphoid	ADJ
ajst-32574	87	16	tissues	tissue	NOUN
ajst-32574	87	17	.	.	PUNCT
ajst-32574	88	1	in	in	ADP
ajst-32574	88	2	the	the	DET
ajst-32574	88	3	divid	divid	PROPN
ajst-32574	88	4	study	study	NOUN
ajst-32574	88	5	of	of	ADP
ajst-32574	88	6	newly	newly	ADV
ajst-32574	88	7	diagnosed	diagnose	VERB
ajst-32574	88	8	patients	patient	NOUN
ajst-32574	88	9	,	,	PUNCT
ajst-32574	88	10	oikarinen	oikarinen	NOUN
ajst-32574	88	11	et	et	PROPN
ajst-32574	88	12	al	al	PROPN
ajst-32574	88	13	.	.	PUNCT
ajst-32574	89	1	[	[	X
ajst-32574	89	2	22	22	NUM
ajst-32574	89	3	]	]	PUNCT
ajst-32574	89	4	identified	identify	VERB
ajst-32574	89	5	ev	ev	ADP
ajst-32574	89	6	rna	rna	PROPN
ajst-32574	89	7	in	in	ADP
ajst-32574	89	8	pancreatic	pancreatic	ADJ
ajst-32574	89	9	biopsies	biopsy	NOUN
ajst-32574	89	10	.	.	PUNCT
ajst-32574	90	1	laiho	laiho	PROPN
ajst-32574	90	2	et	et	PROPN
ajst-32574	90	3	al	al	PROPN
ajst-32574	90	4	.	.	PUNCT
ajst-32574	91	1	[	[	X
ajst-32574	91	2	23	23	NUM
ajst-32574	91	3	]	]	PUNCT
ajst-32574	91	4	extended	extend	VERB
ajst-32574	91	5	these	these	DET
ajst-32574	91	6	findings	finding	NOUN
ajst-32574	91	7	to	to	PART
ajst-32574	91	8	organ	organ	VERB
ajst-32574	91	9	donors	donor	NOUN
ajst-32574	91	10	,	,	PUNCT
ajst-32574	91	11	showing	show	VERB
ajst-32574	91	12	that	that	SCONJ
ajst-32574	91	13	ev	ev	PROPN
ajst-32574	91	14	rna	rna	PROPN
ajst-32574	91	15	was	be	AUX
ajst-32574	91	16	more	more	ADV
ajst-32574	91	17	frequently	frequently	ADV
ajst-32574	91	18	detected	detect	VERB
ajst-32574	91	19	in	in	ADP
ajst-32574	91	20	individuals	individual	NOUN
ajst-32574	91	21	with	with	ADP
ajst-32574	91	22	early	early	ADJ
ajst-32574	91	23	autoimmunity	autoimmunity	NOUN
ajst-32574	91	24	or	or	CCONJ
ajst-32574	91	25	insulin	insulin	NOUN
ajst-32574	91	26	-	-	PUNCT
ajst-32574	91	27	positive	positive	ADJ
ajst-32574	91	28	islets	islet	NOUN
ajst-32574	91	29	compared	compare	VERB
ajst-32574	91	30	to	to	ADP
ajst-32574	91	31	those	those	PRON
ajst-32574	91	32	with	with	ADP
ajst-32574	91	33	long	long	ADV
ajst-32574	91	34	-	-	PUNCT
ajst-32574	91	35	standing	stand	VERB
ajst-32574	91	36	type	type	NOUN
ajst-32574	91	37	1	1	NUM
ajst-32574	91	38	diabetes	diabetes	NOUN
ajst-32574	91	39	(	(	PUNCT
ajst-32574	91	40	t1d	t1d	NOUN
ajst-32574	91	41	)	)	PUNCT
ajst-32574	91	42	.	.	PUNCT
ajst-32574	92	1	together	together	ADV
ajst-32574	92	2	,	,	PUNCT
ajst-32574	92	3	these	these	DET
ajst-32574	92	4	studies	study	NOUN
ajst-32574	92	5	provide	provide	VERB
ajst-32574	92	6	consistent	consistent	ADJ
ajst-32574	92	7	biological	biological	ADJ
ajst-32574	92	8	evidence	evidence	NOUN
ajst-32574	92	9	from	from	ADP
ajst-32574	92	10	both	both	DET
ajst-32574	92	11	living	live	VERB
ajst-32574	92	12	patients	patient	NOUN
ajst-32574	92	13	and	and	CCONJ
ajst-32574	92	14	cadaveric	cadaveric	ADJ
ajst-32574	92	15	donors	donor	NOUN
ajst-32574	92	16	,	,	PUNCT
ajst-32574	92	17	supporting	support	VERB
ajst-32574	92	18	the	the	DET
ajst-32574	92	19	hypothesis	hypothesis	NOUN
ajst-32574	92	20	that	that	SCONJ
ajst-32574	92	21	low	low	ADJ
ajst-32574	92	22	-	-	PUNCT
ajst-32574	92	23	grade	grade	NOUN
ajst-32574	92	24	persistent	persistent	NOUN
ajst-32574	92	25	ev	ev	NOUN
ajst-32574	92	26	infections	infection	NOUN
ajst-32574	92	27	may	may	AUX
ajst-32574	92	28	act	act	VERB
ajst-32574	92	29	at	at	ADP
ajst-32574	92	30	early	early	ADJ
ajst-32574	92	31	stages	stage	NOUN
ajst-32574	92	32	of	of	ADP
ajst-32574	92	33	t1d	t1d	PROPN
ajst-32574	92	34	pathogenesis	pathogenesis	NOUN
ajst-32574	92	35	.	.	PUNCT
ajst-32574	93	1	compared	compare	VERB
ajst-32574	93	2	to	to	ADP
ajst-32574	93	3	focusing	focus	VERB
ajst-32574	93	4	only	only	ADV
ajst-32574	93	5	on	on	ADP
ajst-32574	93	6	immune	immune	ADJ
ajst-32574	93	7	abnormalities	abnormality	NOUN
ajst-32574	93	8	and	and	CCONJ
ajst-32574	93	9	β	β	NOUN
ajst-32574	93	10	-	-	NOUN
ajst-32574	93	11	cell	cell	NOUN
ajst-32574	93	12	injury	injury	NOUN
ajst-32574	93	13	induced	induce	VERB
ajst-32574	93	14	by	by	ADP
ajst-32574	93	15	extracellular	extracellular	ADJ
ajst-32574	93	16	vesicles	vesicle	NOUN
ajst-32574	93	17	,	,	PUNCT
ajst-32574	93	18	exploring	explore	VERB
ajst-32574	93	19	the	the	DET
ajst-32574	93	20	epigenetic	epigenetic	ADJ
ajst-32574	93	21	responses	response	NOUN
ajst-32574	93	22	triggered	trigger	VERB
ajst-32574	93	23	by	by	ADP
ajst-32574	93	24	ev	ev	NOUN
ajst-32574	93	25	infections	infection	NOUN
ajst-32574	93	26	and	and	CCONJ
ajst-32574	93	27	identifying	identify	VERB
ajst-32574	93	28	corresponding	correspond	VERB
ajst-32574	93	29	molecular	molecular	ADJ
ajst-32574	93	30	biomarkers	biomarker	NOUN
ajst-32574	93	31	may	may	AUX
ajst-32574	93	32	provide	provide	VERB
ajst-32574	93	33	a	a	DET
ajst-32574	93	34	more	more	ADV
ajst-32574	93	35	comprehensive	comprehensive	ADJ
ajst-32574	93	36	understanding	understanding	NOUN
ajst-32574	93	37	of	of	ADP
ajst-32574	93	38	β	β	NOUN
ajst-32574	93	39	-	-	ADJ
ajst-32574	93	40	cell	cell	NOUN
ajst-32574	93	41	regulatory	regulatory	ADJ
ajst-32574	93	42	mechanisms	mechanism	NOUN
ajst-32574	93	43	in	in	ADP
ajst-32574	93	44	t1d	t1d	PROPN
ajst-32574	93	45	.	.	PUNCT
ajst-32574	94	1	such	such	ADJ
ajst-32574	94	2	investigations	investigation	NOUN
ajst-32574	94	3	could	could	AUX
ajst-32574	94	4	also	also	ADV
ajst-32574	94	5	contribute	contribute	VERB
ajst-32574	94	6	to	to	ADP
ajst-32574	94	7	understanding	understand	VERB
ajst-32574	94	8	how	how	SCONJ
ajst-32574	94	9	environmental	environmental	ADJ
ajst-32574	94	10	exposures	exposure	NOUN
ajst-32574	94	11	translate	translate	VERB
ajst-32574	94	12	into	into	ADP
ajst-32574	94	13	epigenetic	epigenetic	ADJ
ajst-32574	94	14	alterations	alteration	NOUN
ajst-32574	94	15	during	during	ADP
ajst-32574	94	16	autoimmune	autoimmune	ADJ
ajst-32574	94	17	processes	process	NOUN
ajst-32574	94	18	.	.	PUNCT
ajst-32574	95	1	3	3	X
ajst-32574	95	2	.	.	X
ajst-32574	95	3	epigenetic	epigenetic	ADJ
ajst-32574	95	4	mechanisms	mechanism	NOUN
ajst-32574	95	5	bridging	bridge	VERB
ajst-32574	95	6	environment	environment	NOUN
ajst-32574	95	7	and	and	CCONJ
ajst-32574	95	8	autoimmunity	autoimmunity	NOUN
ajst-32574	95	9	3.1	3.1	NUM
ajst-32574	95	10	mechanistic	mechanistic	ADJ
ajst-32574	95	11	pathways	pathway	NOUN
ajst-32574	95	12	beyond	beyond	ADP
ajst-32574	95	13	triggering	trigger	VERB
ajst-32574	95	14	immune	immune	ADJ
ajst-32574	95	15	activation	activation	NOUN
ajst-32574	95	16	,	,	PUNCT
ajst-32574	95	17	environmental	environmental	ADJ
ajst-32574	95	18	factors	factor	NOUN
ajst-32574	95	19	may	may	AUX
ajst-32574	95	20	also	also	ADV
ajst-32574	95	21	contribute	contribute	VERB
ajst-32574	95	22	to	to	ADP
ajst-32574	95	23	the	the	DET
ajst-32574	95	24	development	development	NOUN
ajst-32574	95	25	of	of	ADP
ajst-32574	95	26	t1d	t1d	PROPN
ajst-32574	95	27	by	by	ADP
ajst-32574	95	28	influencing	influence	VERB
ajst-32574	95	29	epigenetic	epigenetic	ADJ
ajst-32574	95	30	regulation	regulation	NOUN
ajst-32574	95	31	.	.	PUNCT
ajst-32574	96	1	building	build	VERB
ajst-32574	96	2	on	on	ADP
ajst-32574	96	3	the	the	DET
ajst-32574	96	4	concept	concept	NOUN
ajst-32574	96	5	of	of	ADP
ajst-32574	96	6	gene	gene	NOUN
ajst-32574	96	7	–	–	PUNCT
ajst-32574	96	8	environment	environment	NOUN
ajst-32574	96	9	interaction	interaction	NOUN
ajst-32574	96	10	,	,	PUNCT
ajst-32574	96	11	environmental	environmental	ADJ
ajst-32574	96	12	triggers	trigger	NOUN
ajst-32574	96	13	interface	interface	NOUN
ajst-32574	96	14	with	with	ADP
ajst-32574	96	15	genetic	genetic	ADJ
ajst-32574	96	16	susceptibility	susceptibility	NOUN
ajst-32574	96	17	through	through	ADP
ajst-32574	96	18	epigenetic	epigenetic	ADJ
ajst-32574	96	19	programs	program	NOUN
ajst-32574	96	20	that	that	PRON
ajst-32574	96	21	shape	shape	VERB
ajst-32574	96	22	immune	immune	ADJ
ajst-32574	96	23	tolerance	tolerance	NOUN
ajst-32574	96	24	and	and	CCONJ
ajst-32574	96	25	β	β	NOUN
ajst-32574	96	26	-	-	NOUN
ajst-32574	96	27	cell	cell	NOUN
ajst-32574	96	28	function	function	NOUN
ajst-32574	96	29	.	.	PUNCT
ajst-32574	97	1	nutritional	nutritional	ADJ
ajst-32574	97	2	factors	factor	NOUN
ajst-32574	97	3	such	such	ADJ
ajst-32574	97	4	as	as	ADP
ajst-32574	97	5	vitamin	vitamin	NOUN
ajst-32574	97	6	d	d	NOUN
ajst-32574	97	7	and	and	CCONJ
ajst-32574	97	8	b	b	X
ajst-32574	97	9	-	-	PUNCT
ajst-32574	97	10	vitamins	vitamin	NOUN
ajst-32574	97	11	can	can	AUX
ajst-32574	97	12	modify	modify	VERB
ajst-32574	97	13	dna	dna	PROPN
ajst-32574	97	14	methylation	methylation	NOUN
ajst-32574	97	15	,	,	PUNCT
ajst-32574	97	16	histone	histone	NOUN
ajst-32574	97	17	marks	mark	NOUN
ajst-32574	97	18	,	,	PUNCT
ajst-32574	97	19	and	and	CCONJ
ajst-32574	97	20	microrna	microrna	PROPN
ajst-32574	97	21	expression	expression	NOUN
ajst-32574	97	22	,	,	PUNCT
ajst-32574	97	23	thereby	thereby	ADV
ajst-32574	97	24	affecting	affect	VERB
ajst-32574	97	25	immune	immune	ADJ
ajst-32574	97	26	regulation	regulation	NOUN
ajst-32574	97	27	and	and	CCONJ
ajst-32574	97	28	inflammatory	inflammatory	ADJ
ajst-32574	97	29	balance	balance	NOUN
ajst-32574	97	30	[	[	X
ajst-32574	97	31	24	24	NUM
ajst-32574	97	32	]	]	PUNCT
ajst-32574	97	33	.	.	PUNCT
ajst-32574	98	1	likewise	likewise	ADV
ajst-32574	98	2	,	,	PUNCT
ajst-32574	98	3	viral	viral	ADJ
ajst-32574	98	4	infections	infection	NOUN
ajst-32574	98	5	have	have	AUX
ajst-32574	98	6	been	be	AUX
ajst-32574	98	7	shown	show	VERB
ajst-32574	98	8	to	to	PART
ajst-32574	98	9	induce	induce	VERB
ajst-32574	98	10	persistent	persistent	ADJ
ajst-32574	98	11	epigenetic	epigenetic	ADJ
ajst-32574	98	12	alterations	alteration	NOUN
ajst-32574	98	13	in	in	ADP
ajst-32574	98	14	immune	immune	ADJ
ajst-32574	98	15	and	and	CCONJ
ajst-32574	98	16	pancreatic	pancreatic	ADJ
ajst-32574	98	17	pathways	pathway	NOUN
ajst-32574	98	18	,	,	PUNCT
ajst-32574	98	19	linking	link	VERB
ajst-32574	98	20	acute	acute	ADJ
ajst-32574	98	21	infection	infection	NOUN
ajst-32574	98	22	to	to	ADP
ajst-32574	98	23	long	long	ADJ
ajst-32574	98	24	-	-	PUNCT
ajst-32574	98	25	term	term	NOUN
ajst-32574	98	26	autoimmune	autoimmune	ADJ
ajst-32574	98	27	susceptibility	susceptibility	NOUN
ajst-32574	98	28	[	[	X
ajst-32574	98	29	25	25	NUM
ajst-32574	98	30	]	]	PUNCT
ajst-32574	98	31	.	.	PUNCT
ajst-32574	99	1	collectively	collectively	ADV
ajst-32574	99	2	,	,	PUNCT
ajst-32574	99	3	these	these	DET
ajst-32574	99	4	researches	research	NOUN
ajst-32574	99	5	suggest	suggest	VERB
ajst-32574	99	6	that	that	SCONJ
ajst-32574	99	7	epigenetic	epigenetic	ADJ
ajst-32574	99	8	mechanisms	mechanism	NOUN
ajst-32574	99	9	act	act	VERB
ajst-32574	99	10	as	as	ADP
ajst-32574	99	11	the	the	DET
ajst-32574	99	12	link	link	NOUN
ajst-32574	99	13	between	between	ADP
ajst-32574	99	14	environmental	environmental	ADJ
ajst-32574	99	15	exposures	exposure	NOUN
ajst-32574	99	16	and	and	CCONJ
ajst-32574	99	17	autoimmune	autoimmune	ADJ
ajst-32574	99	18	dysregulation	dysregulation	NOUN
ajst-32574	99	19	,	,	PUNCT
ajst-32574	99	20	providing	provide	VERB
ajst-32574	99	21	new	new	ADJ
ajst-32574	99	22	insights	insight	NOUN
ajst-32574	99	23	and	and	CCONJ
ajst-32574	99	24	mechanistic	mechanistic	ADJ
ajst-32574	99	25	directions	direction	NOUN
ajst-32574	99	26	for	for	ADP
ajst-32574	99	27	future	future	ADJ
ajst-32574	99	28	t1d	t1d	PROPN
ajst-32574	99	29	research	research	NOUN
ajst-32574	99	30	.	.	PUNCT
ajst-32574	100	1	dna	dna	PROPN
ajst-32574	100	2	methylation	methylation	NOUN
ajst-32574	100	3	,	,	PUNCT
ajst-32574	100	4	histone	histone	NOUN
ajst-32574	100	5	modifications	modification	NOUN
ajst-32574	100	6	,	,	PUNCT
ajst-32574	100	7	and	and	CCONJ
ajst-32574	100	8	non	non	ADJ
ajst-32574	100	9	-	-	ADJ
ajst-32574	100	10	coding	code	VERB
ajst-32574	100	11	rna	rna	NOUN
ajst-32574	100	12	are	be	AUX
ajst-32574	100	13	currently	currently	ADV
ajst-32574	100	14	the	the	DET
ajst-32574	100	15	most	most	ADV
ajst-32574	100	16	important	important	ADJ
ajst-32574	100	17	and	and	CCONJ
ajst-32574	100	18	mainstream	mainstream	ADJ
ajst-32574	100	19	research	research	NOUN
ajst-32574	100	20	directions	direction	NOUN
ajst-32574	100	21	in	in	ADP
ajst-32574	100	22	epigenetics	epigenetic	NOUN
ajst-32574	100	23	.	.	PUNCT
ajst-32574	101	1	dna	dna	PROPN
ajst-32574	101	2	methylation	methylation	NOUN
ajst-32574	101	3	is	be	AUX
ajst-32574	101	4	among	among	ADP
ajst-32574	101	5	the	the	DET
ajst-32574	101	6	most	most	ADV
ajst-32574	101	7	widely	widely	ADV
ajst-32574	101	8	studied	study	VERB
ajst-32574	101	9	epigenetic	epigenetic	ADJ
ajst-32574	101	10	alterations	alteration	NOUN
ajst-32574	101	11	in	in	ADP
ajst-32574	101	12	t1d	t1d	PROPN
ajst-32574	101	13	.	.	PUNCT
ajst-32574	102	1	xie	xie	PROPN
ajst-32574	102	2	et	et	PROPN
ajst-32574	102	3	al	al	PROPN
ajst-32574	102	4	.	.	PUNCT
ajst-32574	103	1	[	[	X
ajst-32574	103	2	26	26	NUM
ajst-32574	103	3	]	]	PUNCT
ajst-32574	103	4	highlighted	highlight	VERB
ajst-32574	103	5	abnormal	abnormal	ADJ
ajst-32574	103	6	methylation	methylation	NOUN
ajst-32574	103	7	at	at	ADP
ajst-32574	103	8	immune	immune	ADJ
ajst-32574	103	9	and	and	CCONJ
ajst-32574	103	10	β	β	NOUN
ajst-32574	103	11	-	-	NOUN
ajst-32574	103	12	cell	cell	NOUN
ajst-32574	103	13	-	-	PUNCT
ajst-32574	103	14	related	relate	VERB
ajst-32574	103	15	genes	gene	NOUN
ajst-32574	103	16	such	such	ADJ
ajst-32574	103	17	as	as	ADP
ajst-32574	103	18	hla	hla	PROPN
ajst-32574	103	19	,	,	PUNCT
ajst-32574	103	20	ins	in	NOUN
ajst-32574	103	21	,	,	PUNCT
ajst-32574	103	22	and	and	CCONJ
ajst-32574	103	23	il2ra	il2ra	VERB
ajst-32574	103	24	,	,	PUNCT
ajst-32574	103	25	which	which	PRON
ajst-32574	103	26	may	may	AUX
ajst-32574	103	27	disrupt	disrupt	VERB
ajst-32574	103	28	immune	immune	ADJ
ajst-32574	103	29	tolerance	tolerance	NOUN
ajst-32574	103	30	and	and	CCONJ
ajst-32574	103	31	increase	increase	VERB
ajst-32574	103	32	β	β	NOUN
ajst-32574	103	33	-	-	NOUN
ajst-32574	103	34	cell	cell	NOUN
ajst-32574	103	35	vulnerability	vulnerability	NOUN
ajst-32574	103	36	.	.	PUNCT
ajst-32574	104	1	akil	akil	PROPN
ajst-32574	104	2	et	et	PROPN
ajst-32574	104	3	al	al	PROPN
ajst-32574	104	4	.	.	PUNCT
ajst-32574	105	1	[	[	X
ajst-32574	105	2	27	27	NUM
ajst-32574	105	3	]	]	PUNCT
ajst-32574	105	4	further	far	ADV
ajst-32574	105	5	noted	note	VERB
ajst-32574	105	6	that	that	SCONJ
ajst-32574	105	7	metabolic	metabolic	NOUN
ajst-32574	105	8	cofactors	cofactor	NOUN
ajst-32574	105	9	and	and	CCONJ
ajst-32574	105	10	nutritional	nutritional	ADJ
ajst-32574	105	11	inputs	input	NOUN
ajst-32574	105	12	can	can	AUX
ajst-32574	105	13	influence	influence	VERB
ajst-32574	105	14	these	these	DET
ajst-32574	105	15	methylation	methylation	NOUN
ajst-32574	105	16	patterns	pattern	NOUN
ajst-32574	105	17	,	,	PUNCT
ajst-32574	105	18	leading	lead	VERB
ajst-32574	105	19	to	to	ADP
ajst-32574	105	20	immune	immune	ADJ
ajst-32574	105	21	dysregulation	dysregulation	NOUN
ajst-32574	105	22	and	and	CCONJ
ajst-32574	105	23	providing	provide	VERB
ajst-32574	105	24	potential	potential	ADJ
ajst-32574	105	25	therapeutic	therapeutic	ADJ
ajst-32574	105	26	targets	target	NOUN
ajst-32574	105	27	for	for	ADP
ajst-32574	105	28	restoring	restore	VERB
ajst-32574	105	29	a	a	DET
ajst-32574	105	30	normal	normal	ADJ
ajst-32574	105	31	methylation	methylation	NOUN
ajst-32574	105	32	balance	balance	NOUN
ajst-32574	105	33	.	.	PUNCT
ajst-32574	106	1	histone	histone	NOUN
ajst-32574	106	2	modifications	modification	NOUN
ajst-32574	106	3	also	also	ADV
ajst-32574	106	4	play	play	VERB
ajst-32574	106	5	a	a	DET
ajst-32574	106	6	significant	significant	ADJ
ajst-32574	106	7	role	role	NOUN
ajst-32574	106	8	in	in	ADP
ajst-32574	106	9	shaping	shape	VERB
ajst-32574	106	10	gene	gene	NOUN
ajst-32574	106	11	accessibility	accessibility	NOUN
ajst-32574	106	12	and	and	CCONJ
ajst-32574	106	13	transcriptional	transcriptional	ADJ
ajst-32574	106	14	activity	activity	NOUN
ajst-32574	106	15	.	.	PUNCT
ajst-32574	107	1	xie	xie	PROPN
ajst-32574	107	2	et	et	PROPN
ajst-32574	107	3	al	al	PROPN
ajst-32574	107	4	.	.	PUNCT
ajst-32574	108	1	[	[	X
ajst-32574	108	2	26	26	NUM
ajst-32574	108	3	]	]	PUNCT
ajst-32574	108	4	reported	report	VERB
ajst-32574	108	5	that	that	SCONJ
ajst-32574	108	6	aberrant	aberrant	ADJ
ajst-32574	108	7	acetylation	acetylation	NOUN
ajst-32574	108	8	and	and	CCONJ
ajst-32574	108	9	methylation	methylation	NOUN
ajst-32574	108	10	of	of	ADP
ajst-32574	108	11	histones	histone	NOUN
ajst-32574	108	12	can	can	AUX
ajst-32574	108	13	alter	alter	VERB
ajst-32574	108	14	chromatin	chromatin	NOUN
ajst-32574	108	15	structure	structure	NOUN
ajst-32574	108	16	,	,	PUNCT
ajst-32574	108	17	thereby	thereby	ADV
ajst-32574	108	18	modulating	modulate	VERB
ajst-32574	108	19	immune	immune	ADJ
ajst-32574	108	20	activation	activation	NOUN
ajst-32574	108	21	and	and	CCONJ
ajst-32574	108	22	β	β	NOUN
ajst-32574	108	23	-	-	NOUN
ajst-32574	108	24	cell	cell	NOUN
ajst-32574	108	25	stress	stress	NOUN
ajst-32574	108	26	responses	response	NOUN
ajst-32574	108	27	.	.	PUNCT
ajst-32574	109	1	akil	akil	PROPN
ajst-32574	109	2	et	et	PROPN
ajst-32574	109	3	al	al	PROPN
ajst-32574	109	4	.	.	PUNCT
ajst-32574	110	1	[	[	X
ajst-32574	110	2	27	27	NUM
ajst-32574	110	3	]	]	PUNCT
ajst-32574	110	4	expanded	expand	VERB
ajst-32574	110	5	this	this	DET
ajst-32574	110	6	view	view	NOUN
ajst-32574	110	7	by	by	ADP
ajst-32574	110	8	highlighting	highlight	VERB
ajst-32574	110	9	the	the	DET
ajst-32574	110	10	contribution	contribution	NOUN
ajst-32574	110	11	of	of	ADP
ajst-32574	110	12	histone	histone	NOUN
ajst-32574	110	13	deacetylase	deacetylase	PROPN
ajst-32574	110	14	(	(	PUNCT
ajst-32574	110	15	hdac	hdac	NOUN
ajst-32574	110	16	)	)	PUNCT
ajst-32574	110	17	dysregulation	dysregulation	NOUN
ajst-32574	110	18	in	in	ADP
ajst-32574	110	19	immune	immune	ADJ
ajst-32574	110	20	imbalance	imbalance	NOUN
ajst-32574	110	21	and	and	CCONJ
ajst-32574	110	22	β	β	NOUN
ajst-32574	110	23	-	-	NOUN
ajst-32574	110	24	cell	cell	NOUN
ajst-32574	110	25	apoptosis	apoptosis	NOUN
ajst-32574	110	26	,	,	PUNCT
ajst-32574	110	27	and	and	CCONJ
ajst-32574	110	28	proposed	propose	VERB
ajst-32574	110	29	hdac	hdac	NOUN
ajst-32574	110	30	inhibitors	inhibitor	NOUN
ajst-32574	110	31	as	as	ADP
ajst-32574	110	32	potential	potential	ADJ
ajst-32574	110	33	therapeutic	therapeutic	ADJ
ajst-32574	110	34	candidates	candidate	NOUN
ajst-32574	110	35	.	.	PUNCT
ajst-32574	111	1	non	non	ADJ
ajst-32574	111	2	-	-	ADJ
ajst-32574	111	3	coding	coding	ADJ
ajst-32574	111	4	rnas	rna	NOUN
ajst-32574	111	5	constitute	constitute	VERB
ajst-32574	111	6	another	another	DET
ajst-32574	111	7	layer	layer	NOUN
ajst-32574	111	8	of	of	ADP
ajst-32574	111	9	epigenetic	epigenetic	ADJ
ajst-32574	111	10	regulation	regulation	NOUN
ajst-32574	111	11	.	.	PUNCT
ajst-32574	112	1	xie	xie	PROPN
ajst-32574	112	2	et	et	PROPN
ajst-32574	112	3	al	al	PROPN
ajst-32574	112	4	.	.	PUNCT
ajst-32574	113	1	[	[	X
ajst-32574	113	2	26	26	NUM
ajst-32574	113	3	]	]	PUNCT
ajst-32574	113	4	described	describe	VERB
ajst-32574	113	5	how	how	SCONJ
ajst-32574	113	6	altered	altered	ADJ
ajst-32574	113	7	mirnas	mirna	NOUN
ajst-32574	113	8	,	,	PUNCT
ajst-32574	113	9	such	such	ADJ
ajst-32574	113	10	as	as	ADP
ajst-32574	113	11	mir-21	mir-21	NOUN
ajst-32574	113	12	,	,	PUNCT
ajst-32574	113	13	mir-34a	mir-34a	NOUN
ajst-32574	113	14	,	,	PUNCT
ajst-32574	113	15	and	and	CCONJ
ajst-32574	113	16	mir-146a	mir-146a	ADJ
ajst-32574	113	17	,	,	PUNCT
ajst-32574	113	18	can	can	AUX
ajst-32574	113	19	modulate	modulate	VERB
ajst-32574	113	20	immune	immune	ADJ
ajst-32574	113	21	signaling	signaling	NOUN
ajst-32574	113	22	and	and	CCONJ
ajst-32574	113	23	β	β	NOUN
ajst-32574	113	24	-	-	NOUN
ajst-32574	113	25	cell	cell	NOUN
ajst-32574	113	26	function	function	NOUN
ajst-32574	113	27	,	,	PUNCT
ajst-32574	113	28	promoting	promote	VERB
ajst-32574	113	29	either	either	CCONJ
ajst-32574	113	30	pro	pro	ADJ
ajst-32574	113	31	-	-	ADJ
ajst-32574	113	32	inflammatory	inflammatory	ADJ
ajst-32574	113	33	or	or	CCONJ
ajst-32574	113	34	protective	protective	ADJ
ajst-32574	113	35	responses	response	NOUN
ajst-32574	113	36	.	.	PUNCT
ajst-32574	114	1	akil	akil	PROPN
ajst-32574	114	2	et	et	PROPN
ajst-32574	114	3	al	al	PROPN
ajst-32574	114	4	.	.	PUNCT
ajst-32574	115	1	[	[	X
ajst-32574	115	2	27	27	NUM
ajst-32574	115	3	]	]	PUNCT
ajst-32574	115	4	further	far	ADV
ajst-32574	115	5	proposed	propose	VERB
ajst-32574	115	6	that	that	SCONJ
ajst-32574	115	7	inflammation	inflammation	NOUN
ajst-32574	115	8	-	-	PUNCT
ajst-32574	115	9	induced	induce	VERB
ajst-32574	115	10	disruptions	disruption	NOUN
ajst-32574	115	11	of	of	ADP
ajst-32574	115	12	the	the	DET
ajst-32574	115	13	mirna	mirna	PROPN
ajst-32574	115	14	–	–	PUNCT
ajst-32574	115	15	mrna	mrna	PROPN
ajst-32574	115	16	network	network	NOUN
ajst-32574	115	17	may	may	AUX
ajst-32574	115	18	amplify	amplify	VERB
ajst-32574	115	19	β	β	NOUN
ajst-32574	115	20	-	-	NOUN
ajst-32574	115	21	cell	cell	NOUN
ajst-32574	115	22	apoptosis	apoptosis	NOUN
ajst-32574	115	23	,	,	PUNCT
ajst-32574	115	24	while	while	SCONJ
ajst-32574	115	25	long	long	ADJ
ajst-32574	115	26	non	non	ADJ
ajst-32574	115	27	-	-	ADJ
ajst-32574	115	28	coding	coding	ADJ
ajst-32574	115	29	rnas	rna	NOUN
ajst-32574	115	30	could	could	AUX
ajst-32574	115	31	fine	fine	ADJ
ajst-32574	115	32	-	-	PUNCT
ajst-32574	115	33	tune	tune	NOUN
ajst-32574	115	34	survival	survival	NOUN
ajst-32574	115	35	and	and	CCONJ
ajst-32574	115	36	stress	stress	NOUN
ajst-32574	115	37	pathways	pathway	NOUN
ajst-32574	115	38	,	,	PUNCT
ajst-32574	115	39	highlighting	highlight	VERB
ajst-32574	115	40	their	their	PRON
ajst-32574	115	41	potential	potential	NOUN
ajst-32574	115	42	as	as	ADP
ajst-32574	115	43	biomarkers	biomarker	NOUN
ajst-32574	115	44	.	.	PUNCT
ajst-32574	116	1	3.2	3.2	NUM
ajst-32574	116	2	empirical	empirical	ADJ
ajst-32574	116	3	evidence	evidence	NOUN
ajst-32574	116	4	much	much	ADJ
ajst-32574	116	5	empirical	empirical	ADJ
ajst-32574	116	6	evidence	evidence	NOUN
ajst-32574	116	7	supports	support	VERB
ajst-32574	116	8	this	this	DET
ajst-32574	116	9	view	view	NOUN
ajst-32574	116	10	.	.	PUNCT
ajst-32574	117	1	čugalj	čugalj	PROPN
ajst-32574	117	2	kern	kern	PROPN
ajst-32574	117	3	et	et	PROPN
ajst-32574	117	4	al	al	PROPN
ajst-32574	117	5	.	.	PUNCT
ajst-32574	118	1	[	[	X
ajst-32574	118	2	28	28	NUM
ajst-32574	118	3	]	]	PUNCT
ajst-32574	118	4	conducted	conduct	VERB
ajst-32574	118	5	an	an	DET
ajst-32574	118	6	epigenomewide	epigenomewide	NOUN
ajst-32574	118	7	dna	dna	PROPN
ajst-32574	118	8	methylation	methylation	NOUN
ajst-32574	118	9	analysis	analysis	NOUN
ajst-32574	118	10	in	in	ADP
ajst-32574	118	11	peripheral	peripheral	ADJ
ajst-32574	118	12	blood	blood	NOUN
ajst-32574	118	13	samples	sample	NOUN
ajst-32574	118	14	from	from	ADP
ajst-32574	118	15	children	child	NOUN
ajst-32574	118	16	and	and	CCONJ
ajst-32574	118	17	adolescents	adolescent	NOUN
ajst-32574	118	18	with	with	ADP
ajst-32574	118	19	recently	recently	ADV
ajst-32574	118	20	diagnosed	diagnose	VERB
ajst-32574	118	21	t1d	t1d	PROPN
ajst-32574	118	22	,	,	PUNCT
ajst-32574	118	23	stratified	stratify	VERB
ajst-32574	118	24	by	by	ADP
ajst-32574	118	25	long	long	ADJ
ajst-32574	118	26	-	-	PUNCT
ajst-32574	118	27	term	term	NOUN
ajst-32574	118	28	glycemic	glycemic	ADJ
ajst-32574	118	29	control	control	NOUN
ajst-32574	118	30	(	(	PUNCT
ajst-32574	118	31	hba1c	hba1c	X
ajst-32574	118	32	<	<	X
ajst-32574	118	33	7	7	NUM
ajst-32574	118	34	%	%	NOUN
ajst-32574	118	35	vs.	vs.	ADP
ajst-32574	118	36	>	>	X
ajst-32574	118	37	8	8	NUM
ajst-32574	118	38	%	%	NOUN
ajst-32574	118	39	)	)	PUNCT
ajst-32574	118	40	.	.	PUNCT
ajst-32574	119	1	using	use	VERB
ajst-32574	119	2	illumina	illumina	PROPN
ajst-32574	119	3	epic	epic	PROPN
ajst-32574	119	4	arrays	array	VERB
ajst-32574	119	5	,	,	PUNCT
ajst-32574	119	6	they	they	PRON
ajst-32574	119	7	identified	identify	VERB
ajst-32574	119	8	more	more	ADJ
ajst-32574	119	9	than	than	ADP
ajst-32574	119	10	8,000	8,000	NUM
ajst-32574	119	11	differentially	differentially	ADV
ajst-32574	119	12	methylated	methylate	VERB
ajst-32574	119	13	cpg	cpg	NOUN
ajst-32574	119	14	sites	site	NOUN
ajst-32574	119	15	annotated	annotate	VERB
ajst-32574	119	16	209	209	NUM
ajst-32574	119	17	to	to	ADP
ajst-32574	119	18	over	over	ADP
ajst-32574	119	19	1,800	1,800	NUM
ajst-32574	119	20	genes	gene	NOUN
ajst-32574	119	21	,	,	PUNCT
ajst-32574	119	22	many	many	ADJ
ajst-32574	119	23	of	of	ADP
ajst-32574	119	24	which	which	PRON
ajst-32574	119	25	were	be	AUX
ajst-32574	119	26	involved	involve	VERB
ajst-32574	119	27	in	in	ADP
ajst-32574	119	28	inflammatory	inflammatory	ADJ
ajst-32574	119	29	signaling	signal	VERB
ajst-32574	119	30	,	,	PUNCT
ajst-32574	119	31	immune	immune	ADJ
ajst-32574	119	32	regulation	regulation	NOUN
ajst-32574	119	33	,	,	PUNCT
ajst-32574	119	34	and	and	CCONJ
ajst-32574	119	35	β	β	X
ajst-32574	119	36	-	-	NOUN
ajst-32574	119	37	cell	cell	NOUN
ajst-32574	119	38	function	function	NOUN
ajst-32574	119	39	.	.	PUNCT
ajst-32574	120	1	these	these	DET
ajst-32574	120	2	findings	finding	NOUN
ajst-32574	120	3	indicate	indicate	VERB
ajst-32574	120	4	that	that	SCONJ
ajst-32574	120	5	even	even	ADV
ajst-32574	120	6	in	in	ADP
ajst-32574	120	7	the	the	DET
ajst-32574	120	8	early	early	ADJ
ajst-32574	120	9	stages	stage	NOUN
ajst-32574	120	10	of	of	ADP
ajst-32574	120	11	disease	disease	NOUN
ajst-32574	120	12	,	,	PUNCT
ajst-32574	120	13	and	and	CCONJ
ajst-32574	120	14	in	in	ADP
ajst-32574	120	15	the	the	DET
ajst-32574	120	16	absence	absence	NOUN
ajst-32574	120	17	of	of	ADP
ajst-32574	120	18	chronic	chronic	ADJ
ajst-32574	120	19	complications	complication	NOUN
ajst-32574	120	20	,	,	PUNCT
ajst-32574	120	21	dysregulated	dysregulate	VERB
ajst-32574	120	22	glycemic	glycemic	ADJ
ajst-32574	120	23	control	control	NOUN
ajst-32574	120	24	is	be	AUX
ajst-32574	120	25	accompanied	accompany	VERB
ajst-32574	120	26	by	by	ADP
ajst-32574	120	27	widespread	widespread	ADJ
ajst-32574	120	28	dna	dna	PROPN
ajst-32574	120	29	methylation	methylation	NOUN
ajst-32574	120	30	alterations	alteration	NOUN
ajst-32574	120	31	that	that	PRON
ajst-32574	120	32	affect	affect	VERB
ajst-32574	120	33	immune	immune	ADJ
ajst-32574	120	34	and	and	CCONJ
ajst-32574	120	35	metabolic	metabolic	NOUN
ajst-32574	120	36	pathways	pathway	NOUN
ajst-32574	120	37	.	.	PUNCT
ajst-32574	121	1	similarly	similarly	ADV
ajst-32574	121	2	,	,	PUNCT
ajst-32574	121	3	paul	paul	PROPN
ajst-32574	121	4	et	et	PROPN
ajst-32574	121	5	al	al	PROPN
ajst-32574	121	6	.	.	PUNCT
ajst-32574	122	1	[	[	X
ajst-32574	122	2	29	29	NUM
ajst-32574	122	3	]	]	PUNCT
ajst-32574	122	4	analyzed	analyze	VERB
ajst-32574	122	5	sorted	sort	VERB
ajst-32574	122	6	t	t	NOUN
ajst-32574	122	7	cells	cell	NOUN
ajst-32574	122	8	,	,	PUNCT
ajst-32574	122	9	b	b	NOUN
ajst-32574	122	10	cells	cell	NOUN
ajst-32574	122	11	,	,	PUNCT
ajst-32574	122	12	and	and	CCONJ
ajst-32574	122	13	monocytes	monocyte	VERB
ajst-32574	122	14	from	from	ADP
ajst-32574	122	15	patients	patient	NOUN
ajst-32574	122	16	with	with	ADP
ajst-32574	122	17	t1d	t1d	PROPN
ajst-32574	122	18	and	and	CCONJ
ajst-32574	122	19	matched	match	VERB
ajst-32574	122	20	controls	control	NOUN
ajst-32574	122	21	and	and	CCONJ
ajst-32574	122	22	found	find	VERB
ajst-32574	122	23	that	that	SCONJ
ajst-32574	122	24	methylation	methylation	NOUN
ajst-32574	122	25	variability	variability	NOUN
ajst-32574	122	26	was	be	AUX
ajst-32574	122	27	significantly	significantly	ADV
ajst-32574	122	28	higher	high	ADJ
ajst-32574	122	29	across	across	ADP
ajst-32574	122	30	these	these	DET
ajst-32574	122	31	immune	immune	ADJ
ajst-32574	122	32	effector	effector	NOUN
ajst-32574	122	33	cell	cell	NOUN
ajst-32574	122	34	types	type	NOUN
ajst-32574	122	35	in	in	ADP
ajst-32574	122	36	t1d	t1d	PROPN
ajst-32574	122	37	.	.	PUNCT
ajst-32574	123	1	twin	twin	PROPN
ajst-32574	123	2	studies	study	NOUN
ajst-32574	123	3	further	far	ADV
ajst-32574	123	4	support	support	VERB
ajst-32574	123	5	these	these	DET
ajst-32574	123	6	associations	association	NOUN
ajst-32574	123	7	.	.	PUNCT
ajst-32574	124	1	stefan	stefan	PROPN
ajst-32574	124	2	et	et	PROPN
ajst-32574	124	3	al	al	PROPN
ajst-32574	124	4	.	.	PUNCT
ajst-32574	125	1	[	[	X
ajst-32574	125	2	30	30	NUM
ajst-32574	125	3	]	]	PUNCT
ajst-32574	125	4	examined	examine	VERB
ajst-32574	125	5	monozygotic	monozygotic	ADJ
ajst-32574	125	6	twin	twin	ADJ
ajst-32574	125	7	pairs	pair	NOUN
ajst-32574	125	8	discordant	discordant	ADJ
ajst-32574	125	9	for	for	ADP
ajst-32574	125	10	t1d	t1d	PROPN
ajst-32574	125	11	and	and	CCONJ
ajst-32574	125	12	detected	detect	VERB
ajst-32574	125	13	reproducible	reproducible	ADJ
ajst-32574	125	14	methylation	methylation	NOUN
ajst-32574	125	15	differences	difference	NOUN
ajst-32574	125	16	across	across	ADP
ajst-32574	125	17	immune	immune	NOUN
ajst-32574	125	18	-	-	PUNCT
ajst-32574	125	19	related	relate	VERB
ajst-32574	125	20	loci	loci	NOUN
ajst-32574	125	21	,	,	PUNCT
ajst-32574	125	22	demonstrating	demonstrate	VERB
ajst-32574	125	23	that	that	SCONJ
ajst-32574	125	24	epigenetic	epigenetic	ADJ
ajst-32574	125	25	divergence	divergence	NOUN
ajst-32574	125	26	can	can	AUX
ajst-32574	125	27	occur	occur	VERB
ajst-32574	125	28	despite	despite	SCONJ
ajst-32574	125	29	identical	identical	ADJ
ajst-32574	125	30	genetic	genetic	ADJ
ajst-32574	125	31	backgrounds	background	NOUN
ajst-32574	125	32	.	.	PUNCT
ajst-32574	126	1	collectively	collectively	ADV
ajst-32574	126	2	,	,	PUNCT
ajst-32574	126	3	these	these	DET
ajst-32574	126	4	findings	finding	NOUN
ajst-32574	126	5	suggest	suggest	VERB
ajst-32574	126	6	a	a	DET
ajst-32574	126	7	relationship	relationship	NOUN
ajst-32574	126	8	between	between	ADP
ajst-32574	126	9	epigenetic	epigenetic	ADJ
ajst-32574	126	10	regulation	regulation	NOUN
ajst-32574	126	11	and	and	CCONJ
ajst-32574	126	12	the	the	DET
ajst-32574	126	13	development	development	NOUN
ajst-32574	126	14	of	of	ADP
ajst-32574	126	15	type	type	NOUN
ajst-32574	126	16	1	1	NUM
ajst-32574	126	17	diabetes	diabetes	NOUN
ajst-32574	126	18	.	.	PUNCT
ajst-32574	127	1	more	more	ADV
ajst-32574	127	2	importantly	importantly	ADV
ajst-32574	127	3	,	,	PUNCT
ajst-32574	127	4	longitudinal	longitudinal	ADJ
ajst-32574	127	5	evidence	evidence	NOUN
ajst-32574	127	6	provides	provide	VERB
ajst-32574	127	7	stronger	strong	ADJ
ajst-32574	127	8	indications	indication	NOUN
ajst-32574	127	9	of	of	ADP
ajst-32574	127	10	causality	causality	NOUN
ajst-32574	127	11	.	.	PUNCT
ajst-32574	128	1	johnson	johnson	PROPN
ajst-32574	128	2	et	et	PROPN
ajst-32574	128	3	al	al	PROPN
ajst-32574	128	4	.	.	PUNCT
ajst-32574	129	1	[	[	X
ajst-32574	129	2	31	31	NUM
ajst-32574	129	3	]	]	PUNCT
ajst-32574	129	4	followed	follow	VERB
ajst-32574	129	5	87	87	NUM
ajst-32574	129	6	children	child	NOUN
ajst-32574	129	7	who	who	PRON
ajst-32574	129	8	later	later	ADV
ajst-32574	129	9	developed	develop	VERB
ajst-32574	129	10	t1d	t1d	PROPN
ajst-32574	129	11	and	and	CCONJ
ajst-32574	129	12	87	87	NUM
ajst-32574	129	13	matched	match	VERB
ajst-32574	129	14	controls	control	NOUN
ajst-32574	129	15	in	in	ADP
ajst-32574	129	16	the	the	DET
ajst-32574	129	17	prospective	prospective	ADJ
ajst-32574	129	18	daisy	daisy	NOUN
ajst-32574	129	19	cohort	cohort	NOUN
ajst-32574	129	20	,	,	PUNCT
ajst-32574	129	21	analyzing	analyze	VERB
ajst-32574	129	22	serial	serial	ADJ
ajst-32574	129	23	blood	blood	NOUN
ajst-32574	129	24	samples	sample	NOUN
ajst-32574	129	25	from	from	ADP
ajst-32574	129	26	birth	birth	NOUN
ajst-32574	129	27	through	through	ADP
ajst-32574	129	28	pre	pre	ADJ
ajst-32574	129	29	-	-	ADJ
ajst-32574	129	30	seroconversion	seroconversion	ADJ
ajst-32574	129	31	stages	stage	NOUN
ajst-32574	129	32	using	use	VERB
ajst-32574	129	33	450	450	NUM
ajst-32574	129	34	k	k	NOUN
ajst-32574	129	35	and	and	CCONJ
ajst-32574	129	36	epic	epic	ADJ
ajst-32574	129	37	methylation	methylation	NOUN
ajst-32574	129	38	arrays	array	VERB
ajst-32574	129	39	.	.	PUNCT
ajst-32574	130	1	they	they	PRON
ajst-32574	130	2	identified	identify	VERB
ajst-32574	130	3	differential	differential	ADJ
ajst-32574	130	4	trajectories	trajectory	NOUN
ajst-32574	130	5	of	of	ADP
ajst-32574	130	6	methylation	methylation	NOUN
ajst-32574	130	7	change	change	NOUN
ajst-32574	130	8	across	across	ADP
ajst-32574	130	9	multiple	multiple	ADJ
ajst-32574	130	10	genomic	genomic	ADJ
ajst-32574	130	11	regions	region	NOUN
ajst-32574	130	12	,	,	PUNCT
ajst-32574	130	13	including	include	VERB
ajst-32574	130	14	hla	hla	PROPN
ajst-32574	130	15	-	-	PUNCT
ajst-32574	130	16	dq	dq	NOUN
ajst-32574	130	17	,	,	PUNCT
ajst-32574	130	18	ins	in	NOUN
ajst-32574	130	19	,	,	PUNCT
ajst-32574	130	20	and	and	CCONJ
ajst-32574	130	21	il2ra	il2ra	VERB
ajst-32574	130	22	,	,	PUNCT
ajst-32574	130	23	long	long	ADV
ajst-32574	130	24	before	before	ADP
ajst-32574	130	25	the	the	DET
ajst-32574	130	26	onset	onset	NOUN
ajst-32574	130	27	of	of	ADP
ajst-32574	130	28	autoantibodies	autoantibody	NOUN
ajst-32574	130	29	or	or	CCONJ
ajst-32574	130	30	clinical	clinical	ADJ
ajst-32574	130	31	symptoms	symptom	NOUN
ajst-32574	130	32	.	.	PUNCT
ajst-32574	131	1	some	some	DET
ajst-32574	131	2	alterations	alteration	NOUN
ajst-32574	131	3	were	be	AUX
ajst-32574	131	4	already	already	ADV
ajst-32574	131	5	detectable	detectable	ADJ
ajst-32574	131	6	at	at	ADP
ajst-32574	131	7	birth	birth	NOUN
ajst-32574	131	8	,	,	PUNCT
ajst-32574	131	9	implying	imply	VERB
ajst-32574	131	10	early	early	ADJ
ajst-32574	131	11	-	-	PUNCT
ajst-32574	131	12	life	life	NOUN
ajst-32574	131	13	epigenetic	epigenetic	ADJ
ajst-32574	131	14	programming	programming	NOUN
ajst-32574	131	15	of	of	ADP
ajst-32574	131	16	immune	immune	ADJ
ajst-32574	131	17	risk	risk	NOUN
ajst-32574	131	18	.	.	PUNCT
ajst-32574	132	1	these	these	DET
ajst-32574	132	2	data	datum	NOUN
ajst-32574	132	3	suggest	suggest	VERB
ajst-32574	132	4	that	that	SCONJ
ajst-32574	132	5	progressive	progressive	ADJ
ajst-32574	132	6	methylation	methylation	NOUN
ajst-32574	132	7	shifts	shift	NOUN
ajst-32574	132	8	compromise	compromise	VERB
ajst-32574	132	9	immune	immune	ADJ
ajst-32574	132	10	tolerance	tolerance	NOUN
ajst-32574	132	11	and	and	CCONJ
ajst-32574	132	12	increase	increase	VERB
ajst-32574	132	13	β	β	NOUN
ajst-32574	132	14	-	-	NOUN
ajst-32574	132	15	cell	cell	NOUN
ajst-32574	132	16	vulnerability	vulnerability	NOUN
ajst-32574	132	17	,	,	PUNCT
ajst-32574	132	18	providing	provide	VERB
ajst-32574	132	19	sufficient	sufficient	ADJ
ajst-32574	132	20	evidence	evidence	NOUN
ajst-32574	132	21	for	for	ADP
ajst-32574	132	22	a	a	DET
ajst-32574	132	23	causal	causal	PROPN
ajst-32574	132	24	association	association	NOUN
ajst-32574	132	25	.	.	PUNCT
ajst-32574	133	1	however	however	ADV
ajst-32574	133	2	,	,	PUNCT
ajst-32574	133	3	most	most	ADJ
ajst-32574	133	4	analyses	analysis	NOUN
ajst-32574	133	5	focus	focus	VERB
ajst-32574	133	6	on	on	ADP
ajst-32574	133	7	single	single	ADJ
ajst-32574	133	8	-	-	PUNCT
ajst-32574	133	9	layer	layer	NOUN
ajst-32574	133	10	methylation	methylation	NOUN
ajst-32574	133	11	data	datum	NOUN
ajst-32574	133	12	and	and	CCONJ
ajst-32574	133	13	peripheral	peripheral	ADJ
ajst-32574	133	14	blood	blood	NOUN
ajst-32574	133	15	samples	sample	NOUN
ajst-32574	133	16	.	.	PUNCT
ajst-32574	134	1	to	to	PART
ajst-32574	134	2	capture	capture	VERB
ajst-32574	134	3	the	the	DET
ajst-32574	134	4	complex	complex	ADJ
ajst-32574	134	5	interactions	interaction	NOUN
ajst-32574	134	6	between	between	ADP
ajst-32574	134	7	epigenetic	epigenetic	ADJ
ajst-32574	134	8	regulation	regulation	NOUN
ajst-32574	134	9	,	,	PUNCT
ajst-32574	134	10	transcriptional	transcriptional	ADJ
ajst-32574	134	11	activity	activity	NOUN
ajst-32574	134	12	,	,	PUNCT
ajst-32574	134	13	and	and	CCONJ
ajst-32574	134	14	metabolic	metabolic	NOUN
ajst-32574	134	15	pathways	pathway	NOUN
ajst-32574	134	16	,	,	PUNCT
ajst-32574	134	17	future	future	ADJ
ajst-32574	134	18	work	work	NOUN
ajst-32574	134	19	could	could	AUX
ajst-32574	134	20	employ	employ	VERB
ajst-32574	134	21	integrated	integrated	ADJ
ajst-32574	134	22	multi	multi	ADJ
ajst-32574	134	23	-	-	ADJ
ajst-32574	134	24	omics	omics	ADJ
ajst-32574	134	25	strategies	strategy	NOUN
ajst-32574	134	26	that	that	PRON
ajst-32574	134	27	reveal	reveal	VERB
ajst-32574	134	28	the	the	DET
ajst-32574	134	29	causal	causal	ADJ
ajst-32574	134	30	mechanisms	mechanism	NOUN
ajst-32574	134	31	underlying	underlie	VERB
ajst-32574	134	32	disease	disease	NOUN
ajst-32574	134	33	progression	progression	NOUN
ajst-32574	134	34	.	.	PUNCT
ajst-32574	135	1	3.3	3.3	NUM
ajst-32574	135	2	muti	muti	NOUN
ajst-32574	135	3	-	-	PUNCT
ajst-32574	135	4	omics	omic	NOUN
ajst-32574	135	5	integration	integration	NOUN
ajst-32574	135	6	to	to	PART
ajst-32574	135	7	explore	explore	VERB
ajst-32574	135	8	causal	causal	ADJ
ajst-32574	135	9	relationships	relationship	NOUN
ajst-32574	135	10	and	and	CCONJ
ajst-32574	135	11	uncover	uncover	VERB
ajst-32574	135	12	the	the	DET
ajst-32574	135	13	mechanisms	mechanism	NOUN
ajst-32574	135	14	related	relate	VERB
ajst-32574	135	15	to	to	ADP
ajst-32574	135	16	epigenetic	epigenetic	ADJ
ajst-32574	135	17	and	and	CCONJ
ajst-32574	135	18	metabolic	metabolic	NOUN
ajst-32574	135	19	regulation	regulation	NOUN
ajst-32574	135	20	,	,	PUNCT
ajst-32574	135	21	integrated	integrate	VERB
ajst-32574	135	22	multi	multi	ADJ
ajst-32574	135	23	-	-	ADJ
ajst-32574	135	24	omics	omics	ADJ
ajst-32574	135	25	approaches	approach	NOUN
ajst-32574	135	26	are	be	AUX
ajst-32574	135	27	increasingly	increasingly	ADV
ajst-32574	135	28	recognized	recognize	VERB
ajst-32574	135	29	as	as	ADP
ajst-32574	135	30	essential	essential	ADJ
ajst-32574	135	31	.	.	PUNCT
ajst-32574	136	1	dna	dna	PROPN
ajst-32574	136	2	methylation	methylation	NOUN
ajst-32574	136	3	,	,	PUNCT
ajst-32574	136	4	histone	histone	NOUN
ajst-32574	136	5	modification	modification	NOUN
ajst-32574	136	6	,	,	PUNCT
ajst-32574	136	7	and	and	CCONJ
ajst-32574	136	8	non	non	ADJ
ajst-32574	136	9	-	-	ADJ
ajst-32574	136	10	coding	coding	ADJ
ajst-32574	136	11	rna	rna	NOUN
ajst-32574	136	12	alterations	alteration	NOUN
ajst-32574	136	13	represent	represent	VERB
ajst-32574	136	14	central	central	ADJ
ajst-32574	136	15	epigenetic	epigenetic	ADJ
ajst-32574	136	16	mechanisms	mechanism	NOUN
ajst-32574	136	17	that	that	PRON
ajst-32574	136	18	drive	drive	VERB
ajst-32574	136	19	immune	immune	ADJ
ajst-32574	136	20	imbalance	imbalance	NOUN
ajst-32574	136	21	and	and	CCONJ
ajst-32574	136	22	β	β	NOUN
ajst-32574	136	23	-	-	NOUN
ajst-32574	136	24	cell	cell	NOUN
ajst-32574	136	25	apoptosis	apoptosis	NOUN
ajst-32574	136	26	in	in	ADP
ajst-32574	136	27	t1d	t1d	PROPN
ajst-32574	136	28	.	.	PUNCT
ajst-32574	137	1	however	however	ADV
ajst-32574	137	2	,	,	PUNCT
ajst-32574	137	3	these	these	DET
ajst-32574	137	4	processes	process	NOUN
ajst-32574	137	5	rarely	rarely	ADV
ajst-32574	137	6	act	act	VERB
ajst-32574	137	7	in	in	ADP
ajst-32574	137	8	isolation	isolation	NOUN
ajst-32574	137	9	.	.	PUNCT
ajst-32574	138	1	single	single	ADJ
ajst-32574	138	2	-	-	PUNCT
ajst-32574	138	3	layer	layer	NOUN
ajst-32574	138	4	analyses	analysis	NOUN
ajst-32574	138	5	can	can	AUX
ajst-32574	138	6	not	not	PART
ajst-32574	138	7	distinguish	distinguish	VERB
ajst-32574	138	8	primary	primary	ADJ
ajst-32574	138	9	regulatory	regulatory	ADJ
ajst-32574	138	10	events	event	NOUN
ajst-32574	138	11	from	from	ADP
ajst-32574	138	12	downstream	downstream	ADJ
ajst-32574	138	13	consequences	consequence	NOUN
ajst-32574	138	14	,	,	PUNCT
ajst-32574	138	15	nor	nor	CCONJ
ajst-32574	138	16	can	can	AUX
ajst-32574	138	17	they	they	PRON
ajst-32574	138	18	reveal	reveal	VERB
ajst-32574	138	19	how	how	SCONJ
ajst-32574	138	20	environmental	environmental	ADJ
ajst-32574	138	21	inputs	input	NOUN
ajst-32574	138	22	are	be	AUX
ajst-32574	138	23	translated	translate	VERB
ajst-32574	138	24	into	into	ADP
ajst-32574	138	25	complex	complex	ADJ
ajst-32574	138	26	molecular	molecular	ADJ
ajst-32574	138	27	outcomes	outcome	NOUN
ajst-32574	138	28	.	.	PUNCT
ajst-32574	139	1	integrating	integrate	VERB
ajst-32574	139	2	genomic	genomic	NOUN
ajst-32574	139	3	,	,	PUNCT
ajst-32574	139	4	epigenomic	epigenomic	ADJ
ajst-32574	139	5	,	,	PUNCT
ajst-32574	139	6	transcriptomic	transcriptomic	ADJ
ajst-32574	139	7	,	,	PUNCT
ajst-32574	139	8	and	and	CCONJ
ajst-32574	139	9	metabolomic	metabolomic	ADJ
ajst-32574	139	10	datasets	dataset	NOUN
ajst-32574	139	11	can	can	AUX
ajst-32574	139	12	delineate	delineate	VERB
ajst-32574	139	13	a	a	DET
ajst-32574	139	14	causal	causal	ADJ
ajst-32574	139	15	cascade	cascade	NOUN
ajst-32574	139	16	,	,	PUNCT
ajst-32574	139	17	progressing	progress	VERB
ajst-32574	139	18	through	through	ADP
ajst-32574	139	19	epigenetic	epigenetic	ADJ
ajst-32574	139	20	modification	modification	NOUN
ajst-32574	139	21	and	and	CCONJ
ajst-32574	139	22	transcriptional	transcriptional	ADJ
ajst-32574	139	23	dysregulation	dysregulation	NOUN
ajst-32574	139	24	,	,	PUNCT
ajst-32574	139	25	and	and	CCONJ
ajst-32574	139	26	culminating	culminate	VERB
ajst-32574	139	27	in	in	ADP
ajst-32574	139	28	metabolic	metabolic	ADJ
ajst-32574	139	29	dysfunction	dysfunction	NOUN
ajst-32574	139	30	.	.	PUNCT
ajst-32574	140	1	such	such	ADJ
ajst-32574	140	2	integration	integration	NOUN
ajst-32574	140	3	is	be	AUX
ajst-32574	140	4	crucial	crucial	ADJ
ajst-32574	140	5	for	for	ADP
ajst-32574	140	6	identifying	identify	VERB
ajst-32574	140	7	the	the	DET
ajst-32574	140	8	key	key	ADJ
ajst-32574	140	9	regulatory	regulatory	ADJ
ajst-32574	140	10	pathways	pathway	NOUN
ajst-32574	140	11	that	that	PRON
ajst-32574	140	12	link	link	VERB
ajst-32574	140	13	immune	immune	ADJ
ajst-32574	140	14	dysregulation	dysregulation	NOUN
ajst-32574	140	15	to	to	ADP
ajst-32574	140	16	β	β	NOUN
ajst-32574	140	17	-	-	NOUN
ajst-32574	140	18	cell	cell	NOUN
ajst-32574	140	19	failure	failure	NOUN
ajst-32574	140	20	and	and	CCONJ
ajst-32574	140	21	for	for	ADP
ajst-32574	140	22	exploring	explore	VERB
ajst-32574	140	23	potential	potential	ADJ
ajst-32574	140	24	therapeutic	therapeutic	ADJ
ajst-32574	140	25	entry	entry	NOUN
ajst-32574	140	26	points	point	NOUN
ajst-32574	140	27	within	within	ADP
ajst-32574	140	28	these	these	DET
ajst-32574	140	29	complex	complex	ADJ
ajst-32574	140	30	networks	network	NOUN
ajst-32574	140	31	.	.	PUNCT
ajst-32574	141	1	[	[	X
ajst-32574	141	2	6	6	NUM
ajst-32574	141	3	]	]	PUNCT
ajst-32574	141	4	based	base	VERB
ajst-32574	141	5	on	on	ADP
ajst-32574	141	6	this	this	DET
ajst-32574	141	7	concept	concept	NOUN
ajst-32574	141	8	,	,	PUNCT
ajst-32574	141	9	codazzi	codazzi	NOUN
ajst-32574	141	10	et	et	NOUN
ajst-32574	141	11	al	al	PROPN
ajst-32574	141	12	.	.	PUNCT
ajst-32574	142	1	[	[	X
ajst-32574	142	2	32	32	NUM
ajst-32574	142	3	]	]	PUNCT
ajst-32574	142	4	conducted	conduct	VERB
ajst-32574	142	5	a	a	DET
ajst-32574	142	6	large	large	ADJ
ajst-32574	142	7	-	-	PUNCT
ajst-32574	142	8	scale	scale	NOUN
ajst-32574	142	9	empirical	empirical	ADJ
ajst-32574	142	10	effort	effort	NOUN
ajst-32574	142	11	to	to	PART
ajst-32574	142	12	integrate	integrate	VERB
ajst-32574	142	13	multi	multi	ADJ
ajst-32574	142	14	-	-	ADJ
ajst-32574	142	15	omics	omics	ADJ
ajst-32574	142	16	data	datum	NOUN
ajst-32574	142	17	in	in	ADP
ajst-32574	142	18	childhood	childhood	NOUN
ajst-32574	142	19	t1d	t1d	PROPN
ajst-32574	142	20	.	.	PUNCT
ajst-32574	143	1	they	they	PRON
ajst-32574	143	2	analyzed	analyze	VERB
ajst-32574	143	3	146	146	NUM
ajst-32574	143	4	newly	newly	ADV
ajst-32574	143	5	diagnosed	diagnose	VERB
ajst-32574	143	6	children	child	NOUN
ajst-32574	143	7	with	with	ADP
ajst-32574	143	8	t1d	t1d	ADJ
ajst-32574	143	9	using	use	VERB
ajst-32574	143	10	an	an	DET
ajst-32574	143	11	integrated	integrated	ADJ
ajst-32574	143	12	approach	approach	NOUN
ajst-32574	143	13	that	that	SCONJ
ajst-32574	143	14	combined	combine	VERB
ajst-32574	143	15	whole	whole	ADJ
ajst-32574	143	16	-	-	PUNCT
ajst-32574	143	17	blood	blood	NOUN
ajst-32574	143	18	transcriptomic	transcriptomic	ADJ
ajst-32574	143	19	profiles	profile	NOUN
ajst-32574	143	20	,	,	PUNCT
ajst-32574	143	21	circulating	circulate	VERB
ajst-32574	143	22	immune	immune	ADJ
ajst-32574	143	23	factors	factor	NOUN
ajst-32574	143	24	,	,	PUNCT
ajst-32574	143	25	and	and	CCONJ
ajst-32574	143	26	serum	serum	NOUN
ajst-32574	143	27	metabolic	metabolic	NOUN
ajst-32574	143	28	hormones	hormone	NOUN
ajst-32574	143	29	through	through	ADP
ajst-32574	143	30	an	an	DET
ajst-32574	143	31	unsupervised	unsupervised	ADJ
ajst-32574	143	32	multi	multi	ADJ
ajst-32574	143	33	-	-	ADJ
ajst-32574	143	34	omics	omics	ADJ
ajst-32574	143	35	factor	factor	NOUN
ajst-32574	143	36	analysis	analysis	NOUN
ajst-32574	143	37	.	.	PUNCT
ajst-32574	144	1	twelve	twelve	NUM
ajst-32574	144	2	latent	latent	NOUN
ajst-32574	144	3	factors	factor	NOUN
ajst-32574	144	4	were	be	AUX
ajst-32574	144	5	identified	identify	VERB
ajst-32574	144	6	,	,	PUNCT
ajst-32574	144	7	capturing	capture	VERB
ajst-32574	144	8	shared	shared	ADJ
ajst-32574	144	9	variation	variation	NOUN
ajst-32574	144	10	across	across	ADP
ajst-32574	144	11	omics	omic	NOUN
ajst-32574	144	12	layers	layer	NOUN
ajst-32574	144	13	.	.	PUNCT
ajst-32574	145	1	however	however	ADV
ajst-32574	145	2	,	,	PUNCT
ajst-32574	145	3	none	none	NOUN
ajst-32574	145	4	successfully	successfully	ADV
ajst-32574	145	5	distinguished	distinguish	VERB
ajst-32574	145	6	clinical	clinical	ADJ
ajst-32574	145	7	subtypes	subtype	NOUN
ajst-32574	145	8	or	or	CCONJ
ajst-32574	145	9	correlated	correlate	VERB
ajst-32574	145	10	with	with	ADP
ajst-32574	145	11	parameters	parameter	NOUN
ajst-32574	145	12	,	,	PUNCT
ajst-32574	145	13	such	such	ADJ
ajst-32574	145	14	as	as	ADP
ajst-32574	145	15	age	age	NOUN
ajst-32574	145	16	,	,	PUNCT
ajst-32574	145	17	hla	hla	NOUN
ajst-32574	145	18	genotype	genotype	NOUN
ajst-32574	145	19	or	or	CCONJ
ajst-32574	145	20	cpeptide	cpeptide	NOUN
ajst-32574	145	21	levels	level	NOUN
ajst-32574	145	22	.	.	PUNCT
ajst-32574	146	1	they	they	PRON
ajst-32574	146	2	concluded	conclude	VERB
ajst-32574	146	3	that	that	SCONJ
ajst-32574	146	4	multi	multi	ADJ
ajst-32574	146	5	-	-	ADJ
ajst-32574	146	6	omics	omics	ADJ
ajst-32574	146	7	approaches	approach	NOUN
ajst-32574	146	8	remain	remain	VERB
ajst-32574	146	9	constrained	constrain	VERB
ajst-32574	146	10	by	by	ADP
ajst-32574	146	11	late	late	ADJ
ajst-32574	146	12	sampling	sampling	NOUN
ajst-32574	146	13	and	and	CCONJ
ajst-32574	146	14	the	the	DET
ajst-32574	146	15	use	use	NOUN
ajst-32574	146	16	of	of	ADP
ajst-32574	146	17	non	non	ADJ
ajst-32574	146	18	-	-	ADJ
ajst-32574	146	19	specific	specific	ADJ
ajst-32574	146	20	tissue	tissue	NOUN
ajst-32574	146	21	.	.	PUNCT
ajst-32574	147	1	because	because	SCONJ
ajst-32574	147	2	blood	blood	NOUN
ajst-32574	147	3	profiles	profile	NOUN
ajst-32574	147	4	at	at	ADP
ajst-32574	147	5	diagnosis	diagnosis	NOUN
ajst-32574	147	6	reflect	reflect	VERB
ajst-32574	147	7	a	a	DET
ajst-32574	147	8	downstream	downstream	ADJ
ajst-32574	147	9	immune	immune	ADJ
ajst-32574	147	10	state	state	NOUN
ajst-32574	147	11	instead	instead	ADV
ajst-32574	147	12	of	of	ADP
ajst-32574	147	13	early	early	ADJ
ajst-32574	147	14	events	event	NOUN
ajst-32574	147	15	,	,	PUNCT
ajst-32574	147	16	future	future	ADJ
ajst-32574	147	17	studies	study	NOUN
ajst-32574	147	18	should	should	AUX
ajst-32574	147	19	focus	focus	VERB
ajst-32574	147	20	on	on	ADP
ajst-32574	147	21	longitudinal	longitudinal	ADJ
ajst-32574	147	22	sampling	sampling	NOUN
ajst-32574	147	23	and	and	CCONJ
ajst-32574	147	24	tissue	tissue	NOUN
ajst-32574	147	25	-	-	PUNCT
ajst-32574	147	26	specific	specific	ADJ
ajst-32574	147	27	analyses	analysis	NOUN
ajst-32574	147	28	to	to	PART
ajst-32574	147	29	uncover	uncover	VERB
ajst-32574	147	30	causal	causal	ADJ
ajst-32574	147	31	relationship	relationship	NOUN
ajst-32574	147	32	.	.	PUNCT
ajst-32574	148	1	these	these	DET
ajst-32574	148	2	methodological	methodological	ADJ
ajst-32574	148	3	limitations	limitation	NOUN
ajst-32574	148	4	underscore	underscore	VERB
ajst-32574	148	5	the	the	DET
ajst-32574	148	6	need	need	NOUN
ajst-32574	148	7	for	for	ADP
ajst-32574	148	8	earlier	early	ADJ
ajst-32574	148	9	and	and	CCONJ
ajst-32574	148	10	tissue	tissue	NOUN
ajst-32574	148	11	-	-	PUNCT
ajst-32574	148	12	specific	specific	ADJ
ajst-32574	148	13	data	datum	NOUN
ajst-32574	148	14	in	in	ADP
ajst-32574	148	15	the	the	DET
ajst-32574	148	16	multi	multi	ADJ
ajst-32574	148	17	-	-	ADJ
ajst-32574	148	18	omics	omics	ADJ
ajst-32574	148	19	design	design	NOUN
ajst-32574	148	20	to	to	PART
ajst-32574	148	21	make	make	VERB
ajst-32574	148	22	epigenetic	epigenetic	ADJ
ajst-32574	148	23	findings	finding	NOUN
ajst-32574	148	24	more	more	ADV
ajst-32574	148	25	relevant	relevant	ADJ
ajst-32574	148	26	for	for	ADP
ajst-32574	148	27	clinical	clinical	ADJ
ajst-32574	148	28	research	research	NOUN
ajst-32574	148	29	.	.	PUNCT
ajst-32574	149	1	the	the	DET
ajst-32574	149	2	application	application	NOUN
ajst-32574	149	3	potential	potential	NOUN
ajst-32574	149	4	of	of	ADP
ajst-32574	149	5	the	the	DET
ajst-32574	149	6	integrative	integrative	ADJ
ajst-32574	149	7	strategies	strategy	NOUN
ajst-32574	149	8	has	have	AUX
ajst-32574	149	9	been	be	AUX
ajst-32574	149	10	further	far	ADV
ajst-32574	149	11	argued	argue	VERB
ajst-32574	149	12	by	by	ADP
ajst-32574	149	13	fyvie	fyvie	PROPN
ajst-32574	149	14	et	et	PROPN
ajst-32574	149	15	al	al	PROPN
ajst-32574	149	16	.	.	PUNCT
ajst-32574	150	1	[	[	X
ajst-32574	150	2	33	33	NUM
ajst-32574	150	3	]	]	PUNCT
ajst-32574	150	4	.	.	PUNCT
ajst-32574	151	1	they	they	PRON
ajst-32574	151	2	discussed	discuss	VERB
ajst-32574	151	3	the	the	DET
ajst-32574	151	4	use	use	NOUN
ajst-32574	151	5	of	of	ADP
ajst-32574	151	6	omics	omic	NOUN
ajst-32574	151	7	-	-	PUNCT
ajst-32574	151	8	based	base	VERB
ajst-32574	151	9	biomarkers	biomarker	NOUN
ajst-32574	151	10	as	as	ADP
ajst-32574	151	11	a	a	DET
ajst-32574	151	12	promising	promising	ADJ
ajst-32574	151	13	way	way	NOUN
ajst-32574	151	14	to	to	PART
ajst-32574	151	15	monitor	monitor	VERB
ajst-32574	151	16	disease	disease	NOUN
ajst-32574	151	17	progression	progression	NOUN
ajst-32574	151	18	and	and	CCONJ
ajst-32574	151	19	treatment	treatment	NOUN
ajst-32574	151	20	response	response	NOUN
ajst-32574	151	21	in	in	ADP
ajst-32574	151	22	t1d	t1d	PROPN
ajst-32574	151	23	.	.	PUNCT
ajst-32574	152	1	examples	example	NOUN
ajst-32574	152	2	include	include	VERB
ajst-32574	152	3	circulating	circulate	VERB
ajst-32574	152	4	micrornas	microrna	NOUN
ajst-32574	152	5	,	,	PUNCT
ajst-32574	152	6	β	β	NOUN
ajst-32574	152	7	-	-	NOUN
ajst-32574	152	8	cell	cell	NOUN
ajst-32574	152	9	-	-	PUNCT
ajst-32574	152	10	derived	derive	VERB
ajst-32574	152	11	cell	cell	NOUN
ajst-32574	152	12	-	-	PUNCT
ajst-32574	152	13	free	free	ADJ
ajst-32574	152	14	210	210	NUM
ajst-32574	152	15	dna	dna	NOUN
ajst-32574	152	16	,	,	PUNCT
ajst-32574	152	17	and	and	CCONJ
ajst-32574	152	18	protein	protein	NOUN
ajst-32574	152	19	marker	marker	NOUN
ajst-32574	152	20	panels	panel	NOUN
ajst-32574	152	21	that	that	PRON
ajst-32574	152	22	can	can	AUX
ajst-32574	152	23	reflect	reflect	VERB
ajst-32574	152	24	β	β	NOUN
ajst-32574	152	25	-	-	NOUN
ajst-32574	152	26	cell	cell	NOUN
ajst-32574	152	27	stress	stress	NOUN
ajst-32574	152	28	and	and	CCONJ
ajst-32574	152	29	immune	immune	ADJ
ajst-32574	152	30	activity	activity	NOUN
ajst-32574	152	31	in	in	ADP
ajst-32574	152	32	real	real	ADJ
ajst-32574	152	33	time	time	NOUN
ajst-32574	152	34	.	.	PUNCT
ajst-32574	153	1	however	however	ADV
ajst-32574	153	2	,	,	PUNCT
ajst-32574	153	3	they	they	PRON
ajst-32574	153	4	also	also	ADV
ajst-32574	153	5	noted	note	VERB
ajst-32574	153	6	that	that	SCONJ
ajst-32574	153	7	current	current	ADJ
ajst-32574	153	8	methods	method	NOUN
ajst-32574	153	9	still	still	ADV
ajst-32574	153	10	face	face	VERB
ajst-32574	153	11	major	major	ADJ
ajst-32574	153	12	technical	technical	ADJ
ajst-32574	153	13	challenges	challenge	NOUN
ajst-32574	153	14	,	,	PUNCT
ajst-32574	153	15	such	such	ADJ
ajst-32574	153	16	as	as	ADP
ajst-32574	153	17	low	low	ADJ
ajst-32574	153	18	detection	detection	NOUN
ajst-32574	153	19	sensitivity	sensitivity	NOUN
ajst-32574	153	20	,	,	PUNCT
ajst-32574	153	21	inconsistent	inconsistent	ADJ
ajst-32574	153	22	results	result	NOUN
ajst-32574	153	23	,	,	PUNCT
ajst-32574	153	24	and	and	CCONJ
ajst-32574	153	25	a	a	DET
ajst-32574	153	26	lack	lack	NOUN
ajst-32574	153	27	of	of	ADP
ajst-32574	153	28	standardized	standardized	ADJ
ajst-32574	153	29	validation	validation	NOUN
ajst-32574	153	30	.	.	PUNCT
ajst-32574	154	1	future	future	ADJ
ajst-32574	154	2	research	research	NOUN
ajst-32574	154	3	integrating	integrate	VERB
ajst-32574	154	4	epigenomic	epigenomic	ADJ
ajst-32574	154	5	,	,	PUNCT
ajst-32574	154	6	transcriptomic	transcriptomic	ADJ
ajst-32574	154	7	,	,	PUNCT
ajst-32574	154	8	proteomic	proteomic	NOUN
ajst-32574	154	9	,	,	PUNCT
ajst-32574	154	10	and	and	CCONJ
ajst-32574	154	11	metabolomic	metabolomic	ADJ
ajst-32574	154	12	data	datum	NOUN
ajst-32574	154	13	may	may	AUX
ajst-32574	154	14	practice	practice	VERB
ajst-32574	154	15	by	by	ADP
ajst-32574	154	16	generating	generate	VERB
ajst-32574	154	17	multiplex	multiplex	PROPN
ajst-32574	154	18	biomarker	biomarker	NOUN
ajst-32574	154	19	panels	panel	NOUN
ajst-32574	154	20	capable	capable	ADJ
ajst-32574	154	21	of	of	ADP
ajst-32574	154	22	early	early	ADJ
ajst-32574	154	23	diagnosis	diagnosis	NOUN
ajst-32574	154	24	,	,	PUNCT
ajst-32574	154	25	patient	patient	ADJ
ajst-32574	154	26	stratification	stratification	NOUN
ajst-32574	154	27	,	,	PUNCT
ajst-32574	154	28	and	and	CCONJ
ajst-32574	154	29	personalized	personalized	ADJ
ajst-32574	154	30	intervention	intervention	NOUN
ajst-32574	154	31	.	.	PUNCT
ajst-32574	155	1	in	in	ADP
ajst-32574	155	2	summary	summary	NOUN
ajst-32574	155	3	,	,	PUNCT
ajst-32574	155	4	multi	multi	ADJ
ajst-32574	155	5	-	-	ADJ
ajst-32574	155	6	omics	omics	ADJ
ajst-32574	155	7	integration	integration	NOUN
ajst-32574	155	8	is	be	AUX
ajst-32574	155	9	both	both	CCONJ
ajst-32574	155	10	a	a	DET
ajst-32574	155	11	technical	technical	ADJ
ajst-32574	155	12	advance	advance	NOUN
ajst-32574	155	13	and	and	CCONJ
ajst-32574	155	14	an	an	DET
ajst-32574	155	15	important	important	ADJ
ajst-32574	155	16	step	step	NOUN
ajst-32574	155	17	toward	toward	ADP
ajst-32574	155	18	connecting	connect	VERB
ajst-32574	155	19	molecular	molecular	ADJ
ajst-32574	155	20	research	research	NOUN
ajst-32574	155	21	with	with	ADP
ajst-32574	155	22	practical	practical	ADJ
ajst-32574	155	23	strategies	strategy	NOUN
ajst-32574	155	24	for	for	ADP
ajst-32574	155	25	early	early	ADJ
ajst-32574	155	26	prevention	prevention	NOUN
ajst-32574	155	27	and	and	CCONJ
ajst-32574	155	28	targeted	target	VERB
ajst-32574	155	29	treatment	treatment	NOUN
ajst-32574	155	30	in	in	ADP
ajst-32574	155	31	t1d	t1d	PROPN
ajst-32574	155	32	.	.	PUNCT
ajst-32574	156	1	4	4	X
ajst-32574	156	2	.	.	X
ajst-32574	156	3	research	research	NOUN
ajst-32574	156	4	outlook	outlook	NOUN
ajst-32574	156	5	although	although	SCONJ
ajst-32574	156	6	research	research	NOUN
ajst-32574	156	7	has	have	AUX
ajst-32574	156	8	explored	explore	VERB
ajst-32574	156	9	the	the	DET
ajst-32574	156	10	environmental	environmental	ADJ
ajst-32574	156	11	and	and	CCONJ
ajst-32574	156	12	epigenetic	epigenetic	ADJ
ajst-32574	156	13	determinants	determinant	NOUN
ajst-32574	156	14	of	of	ADP
ajst-32574	156	15	type	type	NOUN
ajst-32574	156	16	1	1	NUM
ajst-32574	156	17	diabetes	diabetes	NOUN
ajst-32574	156	18	,	,	PUNCT
ajst-32574	156	19	unresolved	unresolved	ADJ
ajst-32574	156	20	issue	issue	NOUN
ajst-32574	156	21	still	still	ADV
ajst-32574	156	22	persists	persist	VERB
ajst-32574	156	23	in	in	ADP
ajst-32574	156	24	understanding	understand	VERB
ajst-32574	156	25	causal	causal	ADJ
ajst-32574	156	26	relationships	relationship	NOUN
ajst-32574	156	27	and	and	CCONJ
ajst-32574	156	28	in	in	ADP
ajst-32574	156	29	integrating	integrate	VERB
ajst-32574	156	30	environmental	environmental	ADJ
ajst-32574	156	31	and	and	CCONJ
ajst-32574	156	32	epigenetic	epigenetic	ADJ
ajst-32574	156	33	perspectives	perspective	NOUN
ajst-32574	156	34	.	.	PUNCT
ajst-32574	157	1	from	from	ADP
ajst-32574	157	2	an	an	DET
ajst-32574	157	3	environmental	environmental	ADJ
ajst-32574	157	4	perspective	perspective	NOUN
ajst-32574	157	5	,	,	PUNCT
ajst-32574	157	6	most	most	ADJ
ajst-32574	157	7	evidence	evidence	NOUN
ajst-32574	157	8	remains	remain	VERB
ajst-32574	157	9	associative	associative	ADJ
ajst-32574	157	10	but	but	CCONJ
ajst-32574	157	11	not	not	PART
ajst-32574	157	12	causal	causal	ADV
ajst-32574	157	13	.	.	PUNCT
ajst-32574	158	1	the	the	DET
ajst-32574	158	2	majority	majority	NOUN
ajst-32574	158	3	of	of	ADP
ajst-32574	158	4	studies	study	NOUN
ajst-32574	158	5	rely	rely	VERB
ajst-32574	158	6	on	on	ADP
ajst-32574	158	7	observational	observational	ADJ
ajst-32574	158	8	or	or	CCONJ
ajst-32574	158	9	cross	cross	ADJ
ajst-32574	158	10	-	-	ADJ
ajst-32574	158	11	sectional	sectional	ADJ
ajst-32574	158	12	designs	design	NOUN
ajst-32574	158	13	that	that	PRON
ajst-32574	158	14	can	can	AUX
ajst-32574	158	15	demonstrate	demonstrate	VERB
ajst-32574	158	16	correlation	correlation	NOUN
ajst-32574	158	17	,	,	PUNCT
ajst-32574	158	18	while	while	SCONJ
ajst-32574	158	19	temporal	temporal	ADJ
ajst-32574	158	20	sequence	sequence	NOUN
ajst-32574	158	21	or	or	CCONJ
ajst-32574	158	22	mechanistic	mechanistic	ADJ
ajst-32574	158	23	linkage	linkage	NOUN
ajst-32574	158	24	is	be	AUX
ajst-32574	158	25	rare	rare	ADJ
ajst-32574	158	26	.	.	PUNCT
ajst-32574	159	1	this	this	DET
ajst-32574	159	2	limitation	limitation	NOUN
ajst-32574	159	3	is	be	AUX
ajst-32574	159	4	evident	evident	ADJ
ajst-32574	159	5	in	in	ADP
ajst-32574	159	6	the	the	DET
ajst-32574	159	7	two	two	NUM
ajst-32574	159	8	most	most	ADV
ajst-32574	159	9	representative	representative	ADJ
ajst-32574	159	10	environmental	environmental	ADJ
ajst-32574	159	11	factors	factor	NOUN
ajst-32574	159	12	:	:	PUNCT
ajst-32574	159	13	vitamin	vitamin	NOUN
ajst-32574	159	14	d	d	NOUN
ajst-32574	159	15	and	and	CCONJ
ajst-32574	159	16	enterovirus	enterovirus	NOUN
ajst-32574	159	17	infection	infection	NOUN
ajst-32574	159	18	.	.	PUNCT
ajst-32574	160	1	the	the	DET
ajst-32574	160	2	former	former	ADJ
ajst-32574	160	3	shows	show	VERB
ajst-32574	160	4	a	a	DET
ajst-32574	160	5	high	high	ADJ
ajst-32574	160	6	prevalence	prevalence	NOUN
ajst-32574	160	7	of	of	ADP
ajst-32574	160	8	deficiency	deficiency	NOUN
ajst-32574	160	9	and	and	CCONJ
ajst-32574	160	10	broad	broad	ADJ
ajst-32574	160	11	epidemiological	epidemiological	ADJ
ajst-32574	160	12	coverage	coverage	NOUN
ajst-32574	160	13	but	but	CCONJ
ajst-32574	160	14	lacks	lack	VERB
ajst-32574	160	15	consistent	consistent	ADJ
ajst-32574	160	16	causal	causal	ADJ
ajst-32574	160	17	confirmation	confirmation	NOUN
ajst-32574	160	18	,	,	PUNCT
ajst-32574	160	19	whereas	whereas	SCONJ
ajst-32574	160	20	the	the	DET
ajst-32574	160	21	latter	latter	ADJ
ajst-32574	160	22	displays	display	VERB
ajst-32574	160	23	a	a	DET
ajst-32574	160	24	much	much	ADV
ajst-32574	160	25	stronger	strong	ADJ
ajst-32574	160	26	and	and	CCONJ
ajst-32574	160	27	more	more	ADV
ajst-32574	160	28	reproducible	reproducible	ADJ
ajst-32574	160	29	association	association	NOUN
ajst-32574	160	30	with	with	ADP
ajst-32574	160	31	t1d	t1d	PROPN
ajst-32574	160	32	,	,	PUNCT
ajst-32574	160	33	yet	yet	CCONJ
ajst-32574	160	34	still	still	ADV
ajst-32574	160	35	exists	exist	VERB
ajst-32574	160	36	molecular	molecular	ADJ
ajst-32574	160	37	mechanisms	mechanism	NOUN
ajst-32574	160	38	incompletely	incompletely	ADV
ajst-32574	160	39	resolved	resolve	VERB
ajst-32574	160	40	.	.	PUNCT
ajst-32574	161	1	these	these	DET
ajst-32574	161	2	two	two	NUM
ajst-32574	161	3	examples	example	NOUN
ajst-32574	161	4	represent	represent	VERB
ajst-32574	161	5	most	most	ADJ
ajst-32574	161	6	of	of	ADP
ajst-32574	161	7	the	the	DET
ajst-32574	161	8	studied	study	VERB
ajst-32574	161	9	links	link	NOUN
ajst-32574	161	10	between	between	ADP
ajst-32574	161	11	environmental	environmental	ADJ
ajst-32574	161	12	exposures	exposure	NOUN
ajst-32574	161	13	and	and	CCONJ
ajst-32574	161	14	t1d	t1d	NOUN
ajst-32574	161	15	.	.	PUNCT
ajst-32574	162	1	they	they	PRON
ajst-32574	162	2	highlight	highlight	VERB
ajst-32574	162	3	the	the	DET
ajst-32574	162	4	current	current	ADJ
ajst-32574	162	5	state	state	NOUN
ajst-32574	162	6	of	of	ADP
ajst-32574	162	7	the	the	DET
ajst-32574	162	8	field	field	NOUN
ajst-32574	162	9	,	,	PUNCT
ajst-32574	162	10	which	which	PRON
ajst-32574	162	11	is	be	AUX
ajst-32574	162	12	characterized	characterize	VERB
ajst-32574	162	13	by	by	ADP
ajst-32574	162	14	an	an	DET
ajst-32574	162	15	abundance	abundance	NOUN
ajst-32574	162	16	of	of	ADP
ajst-32574	162	17	associative	associative	ADJ
ajst-32574	162	18	evidence	evidence	NOUN
ajst-32574	162	19	but	but	CCONJ
ajst-32574	162	20	still	still	ADV
ajst-32574	162	21	lacks	lack	VERB
ajst-32574	162	22	direct	direct	ADJ
ajst-32574	162	23	causal	causal	ADJ
ajst-32574	162	24	validation	validation	NOUN
ajst-32574	162	25	.	.	PUNCT
ajst-32574	163	1	in	in	ADP
ajst-32574	163	2	this	this	DET
ajst-32574	163	3	sense	sense	NOUN
ajst-32574	163	4	,	,	PUNCT
ajst-32574	163	5	vitamin	vitamin	NOUN
ajst-32574	163	6	d	d	NOUN
ajst-32574	163	7	and	and	CCONJ
ajst-32574	163	8	enterovirus	enterovirus	NOUN
ajst-32574	163	9	together	together	ADV
ajst-32574	163	10	illustrate	illustrate	VERB
ajst-32574	163	11	that	that	PRON
ajst-32574	163	12	current	current	ADJ
ajst-32574	163	13	environmental	environmental	ADJ
ajst-32574	163	14	research	research	NOUN
ajst-32574	163	15	on	on	ADP
ajst-32574	163	16	t1d	t1d	PROPN
ajst-32574	163	17	requires	require	VERB
ajst-32574	163	18	more	more	ADV
ajst-32574	163	19	longitudinal	longitudinal	ADJ
ajst-32574	163	20	and	and	CCONJ
ajst-32574	163	21	experimental	experimental	ADJ
ajst-32574	163	22	studies	study	NOUN
ajst-32574	163	23	to	to	PART
ajst-32574	163	24	establish	establish	VERB
ajst-32574	163	25	clear	clear	ADJ
ajst-32574	163	26	causal	causal	ADJ
ajst-32574	163	27	relationships	relationship	NOUN
ajst-32574	163	28	.	.	PUNCT
ajst-32574	164	1	from	from	ADP
ajst-32574	164	2	the	the	DET
ajst-32574	164	3	epigenetic	epigenetic	ADJ
ajst-32574	164	4	perspective	perspective	NOUN
ajst-32574	164	5	,	,	PUNCT
ajst-32574	164	6	the	the	DET
ajst-32574	164	7	principal	principal	ADJ
ajst-32574	164	8	limitation	limitation	NOUN
ajst-32574	164	9	is	be	AUX
ajst-32574	164	10	the	the	DET
ajst-32574	164	11	lack	lack	NOUN
ajst-32574	164	12	of	of	ADP
ajst-32574	164	13	connection	connection	NOUN
ajst-32574	164	14	between	between	ADP
ajst-32574	164	15	environmental	environmental	ADJ
ajst-32574	164	16	exposures	exposure	NOUN
ajst-32574	164	17	,	,	PUNCT
ajst-32574	164	18	molecular	molecular	ADJ
ajst-32574	164	19	regulation	regulation	NOUN
ajst-32574	164	20	,	,	PUNCT
ajst-32574	164	21	and	and	CCONJ
ajst-32574	164	22	immune	immune	ADJ
ajst-32574	164	23	or	or	CCONJ
ajst-32574	164	24	β	β	NOUN
ajst-32574	164	25	-	-	NOUN
ajst-32574	164	26	cell	cell	NOUN
ajst-32574	164	27	outcomes	outcome	NOUN
ajst-32574	164	28	.	.	PUNCT
ajst-32574	165	1	as	as	SCONJ
ajst-32574	165	2	emphasized	emphasize	VERB
ajst-32574	165	3	by	by	ADP
ajst-32574	165	4	xie	xie	PROPN
ajst-32574	165	5	et	et	PROPN
ajst-32574	165	6	al	al	PROPN
ajst-32574	165	7	.	.	PUNCT
ajst-32574	166	1	[	[	X
ajst-32574	166	2	26	26	NUM
ajst-32574	166	3	]	]	PUNCT
ajst-32574	166	4	,	,	PUNCT
ajst-32574	166	5	although	although	SCONJ
ajst-32574	166	6	environmental	environmental	ADJ
ajst-32574	166	7	cues	cue	NOUN
ajst-32574	166	8	can	can	AUX
ajst-32574	166	9	reshape	reshape	VERB
ajst-32574	166	10	gene	gene	NOUN
ajst-32574	166	11	expression	expression	NOUN
ajst-32574	166	12	through	through	ADP
ajst-32574	166	13	epigenetic	epigenetic	ADJ
ajst-32574	166	14	mechanisms	mechanism	NOUN
ajst-32574	166	15	,	,	PUNCT
ajst-32574	166	16	the	the	DET
ajst-32574	166	17	basic	basic	ADJ
ajst-32574	166	18	molecular	molecular	ADJ
ajst-32574	166	19	pathways	pathway	NOUN
ajst-32574	166	20	remain	remain	AUX
ajst-32574	166	21	poorly	poorly	ADV
ajst-32574	166	22	understood	understand	VERB
ajst-32574	166	23	.	.	PUNCT
ajst-32574	167	1	minniakhmetov	minniakhmetov	NOUN
ajst-32574	167	2	et	et	PROPN
ajst-32574	167	3	al	al	PROPN
ajst-32574	167	4	.	.	PUNCT
ajst-32574	168	1	[	[	X
ajst-32574	168	2	6	6	NUM
ajst-32574	168	3	]	]	PUNCT
ajst-32574	168	4	similarly	similarly	ADV
ajst-32574	168	5	indicate	indicate	VERB
ajst-32574	168	6	that	that	SCONJ
ajst-32574	168	7	epigenetic	epigenetic	ADJ
ajst-32574	168	8	studies	study	NOUN
ajst-32574	168	9	in	in	ADP
ajst-32574	168	10	t1d	t1d	PROPN
ajst-32574	168	11	remain	remain	VERB
ajst-32574	168	12	fragmented	fragmented	ADJ
ajst-32574	168	13	,	,	PUNCT
ajst-32574	168	14	with	with	ADP
ajst-32574	168	15	most	most	ADJ
ajst-32574	168	16	investigations	investigation	NOUN
ajst-32574	168	17	focusing	focus	VERB
ajst-32574	168	18	on	on	ADP
ajst-32574	168	19	either	either	CCONJ
ajst-32574	168	20	genetic	genetic	ADJ
ajst-32574	168	21	or	or	CCONJ
ajst-32574	168	22	epigenetic	epigenetic	ADJ
ajst-32574	168	23	aspects	aspect	NOUN
ajst-32574	168	24	independently	independently	ADV
ajst-32574	168	25	,	,	PUNCT
ajst-32574	168	26	rather	rather	ADV
ajst-32574	168	27	than	than	ADP
ajst-32574	168	28	combining	combine	VERB
ajst-32574	168	29	these	these	DET
ajst-32574	168	30	layers	layer	NOUN
ajst-32574	168	31	into	into	ADP
ajst-32574	168	32	a	a	DET
ajst-32574	168	33	unified	unified	ADJ
ajst-32574	168	34	framework	framework	NOUN
ajst-32574	168	35	.	.	PUNCT
ajst-32574	169	1	overcoming	overcome	VERB
ajst-32574	169	2	these	these	DET
ajst-32574	169	3	limitations	limitation	NOUN
ajst-32574	169	4	will	will	AUX
ajst-32574	169	5	require	require	VERB
ajst-32574	169	6	clearer	clear	ADJ
ajst-32574	169	7	methods	method	NOUN
ajst-32574	169	8	and	and	CCONJ
ajst-32574	169	9	more	more	ADV
ajst-32574	169	10	practical	practical	ADJ
ajst-32574	169	11	research	research	NOUN
ajst-32574	169	12	designs	design	NOUN
ajst-32574	169	13	.	.	PUNCT
ajst-32574	170	1	to	to	PART
ajst-32574	170	2	strengthen	strengthen	VERB
ajst-32574	170	3	causal	causal	ADJ
ajst-32574	170	4	evidence	evidence	NOUN
ajst-32574	170	5	,	,	PUNCT
ajst-32574	170	6	future	future	ADJ
ajst-32574	170	7	work	work	NOUN
ajst-32574	170	8	should	should	AUX
ajst-32574	170	9	focus	focus	VERB
ajst-32574	170	10	more	more	ADV
ajst-32574	170	11	on	on	ADP
ajst-32574	170	12	longitudinal	longitudinal	ADJ
ajst-32574	170	13	cohort	cohort	NOUN
ajst-32574	170	14	studies	study	NOUN
ajst-32574	170	15	.	.	PUNCT
ajst-32574	171	1	such	such	ADJ
ajst-32574	171	2	studies	study	NOUN
ajst-32574	171	3	can	can	AUX
ajst-32574	171	4	record	record	VERB
ajst-32574	171	5	when	when	SCONJ
ajst-32574	171	6	environmental	environmental	ADJ
ajst-32574	171	7	exposures	exposure	NOUN
ajst-32574	171	8	occur	occur	VERB
ajst-32574	171	9	,	,	PUNCT
ajst-32574	171	10	how	how	SCONJ
ajst-32574	171	11	they	they	PRON
ajst-32574	171	12	affect	affect	VERB
ajst-32574	171	13	epigenetic	epigenetic	ADJ
ajst-32574	171	14	changes	change	NOUN
ajst-32574	171	15	,	,	PUNCT
ajst-32574	171	16	and	and	CCONJ
ajst-32574	171	17	when	when	SCONJ
ajst-32574	171	18	autoimmune	autoimmune	ADJ
ajst-32574	171	19	reactions	reaction	NOUN
ajst-32574	171	20	begin	begin	VERB
ajst-32574	171	21	.	.	PUNCT
ajst-32574	172	1	this	this	DET
ajst-32574	172	2	approach	approach	NOUN
ajst-32574	172	3	would	would	AUX
ajst-32574	172	4	enable	enable	VERB
ajst-32574	172	5	the	the	DET
ajst-32574	172	6	identification	identification	NOUN
ajst-32574	172	7	of	of	ADP
ajst-32574	172	8	triggers	trigger	NOUN
ajst-32574	172	9	from	from	ADP
ajst-32574	172	10	consequences	consequence	NOUN
ajst-32574	172	11	and	and	CCONJ
ajst-32574	172	12	the	the	DET
ajst-32574	172	13	detection	detection	NOUN
ajst-32574	172	14	of	of	ADP
ajst-32574	172	15	early	early	ADJ
ajst-32574	172	16	molecular	molecular	ADJ
ajst-32574	172	17	changes	change	NOUN
ajst-32574	172	18	that	that	PRON
ajst-32574	172	19	occur	occur	VERB
ajst-32574	172	20	before	before	SCONJ
ajst-32574	172	21	β	β	NOUN
ajst-32574	172	22	-	-	NOUN
ajst-32574	172	23	cell	cell	NOUN
ajst-32574	172	24	autoimmunity	autoimmunity	NOUN
ajst-32574	172	25	develops	develop	VERB
ajst-32574	172	26	.	.	PUNCT
ajst-32574	173	1	at	at	ADP
ajst-32574	173	2	the	the	DET
ajst-32574	173	3	same	same	ADJ
ajst-32574	173	4	time	time	NOUN
ajst-32574	173	5	,	,	PUNCT
ajst-32574	173	6	multi	multi	ADJ
ajst-32574	173	7	-	-	ADJ
ajst-32574	173	8	omics	omics	ADJ
ajst-32574	173	9	approaches	approach	NOUN
ajst-32574	173	10	are	be	AUX
ajst-32574	173	11	useful	useful	ADJ
ajst-32574	173	12	for	for	ADP
ajst-32574	173	13	linking	link	VERB
ajst-32574	173	14	different	different	ADJ
ajst-32574	173	15	biological	biological	ADJ
ajst-32574	173	16	layers	layer	NOUN
ajst-32574	173	17	and	and	CCONJ
ajst-32574	173	18	explaining	explain	VERB
ajst-32574	173	19	how	how	SCONJ
ajst-32574	173	20	environmental	environmental	ADJ
ajst-32574	173	21	factors	factor	NOUN
ajst-32574	173	22	lead	lead	VERB
ajst-32574	173	23	to	to	ADP
ajst-32574	173	24	immune	immune	ADJ
ajst-32574	173	25	changes	change	NOUN
ajst-32574	173	26	.	.	PUNCT
ajst-32574	174	1	as	as	ADP
ajst-32574	174	2	minniakhmetov	minniakhmetov	NOUN
ajst-32574	174	3	et	et	PROPN
ajst-32574	174	4	al	al	PROPN
ajst-32574	174	5	.	.	PUNCT
ajst-32574	175	1	[	[	X
ajst-32574	175	2	6	6	NUM
ajst-32574	175	3	]	]	PUNCT
ajst-32574	175	4	pointed	point	VERB
ajst-32574	175	5	out	out	ADP
ajst-32574	175	6	,	,	PUNCT
ajst-32574	175	7	combining	combine	VERB
ajst-32574	175	8	genomic	genomic	NOUN
ajst-32574	175	9	,	,	PUNCT
ajst-32574	175	10	epigenomic	epigenomic	ADJ
ajst-32574	175	11	,	,	PUNCT
ajst-32574	175	12	transcriptomic	transcriptomic	ADJ
ajst-32574	175	13	,	,	PUNCT
ajst-32574	175	14	and	and	CCONJ
ajst-32574	175	15	metabolomic	metabolomic	ADJ
ajst-32574	175	16	data	datum	NOUN
ajst-32574	175	17	can	can	AUX
ajst-32574	175	18	reveal	reveal	VERB
ajst-32574	175	19	the	the	DET
ajst-32574	175	20	mechanisms	mechanism	NOUN
ajst-32574	175	21	of	of	ADP
ajst-32574	175	22	interaction	interaction	NOUN
ajst-32574	175	23	between	between	ADP
ajst-32574	175	24	environmental	environmental	ADJ
ajst-32574	175	25	exposures	exposure	NOUN
ajst-32574	175	26	and	and	CCONJ
ajst-32574	175	27	genetic	genetic	ADJ
ajst-32574	175	28	risk	risk	NOUN
ajst-32574	175	29	,	,	PUNCT
ajst-32574	175	30	thereby	thereby	ADV
ajst-32574	175	31	reshaping	reshape	VERB
ajst-32574	175	32	immune	immune	ADJ
ajst-32574	175	33	and	and	CCONJ
ajst-32574	175	34	metabolic	metabolic	NOUN
ajst-32574	175	35	pathways	pathway	NOUN
ajst-32574	175	36	.	.	PUNCT
ajst-32574	176	1	using	use	VERB
ajst-32574	176	2	these	these	DET
ajst-32574	176	3	integrative	integrative	ADJ
ajst-32574	176	4	methods	method	NOUN
ajst-32574	176	5	in	in	ADP
ajst-32574	176	6	well	well	ADV
ajst-32574	176	7	-	-	PUNCT
ajst-32574	176	8	defined	define	VERB
ajst-32574	176	9	cohorts	cohort	NOUN
ajst-32574	176	10	will	will	AUX
ajst-32574	176	11	help	help	AUX
ajst-32574	176	12	identify	identify	VERB
ajst-32574	176	13	shared	share	VERB
ajst-32574	176	14	molecular	molecular	ADJ
ajst-32574	176	15	pathways	pathway	NOUN
ajst-32574	176	16	that	that	PRON
ajst-32574	176	17	explain	explain	VERB
ajst-32574	176	18	the	the	DET
ajst-32574	176	19	difference	difference	NOUN
ajst-32574	176	20	of	of	ADP
ajst-32574	176	21	disease	disease	NOUN
ajst-32574	176	22	developments	development	NOUN
ajst-32574	176	23	among	among	ADP
ajst-32574	176	24	individuals	individual	NOUN
ajst-32574	176	25	.	.	PUNCT
ajst-32574	177	1	moreover	moreover	ADV
ajst-32574	177	2	,	,	PUNCT
ajst-32574	177	3	turning	turn	VERB
ajst-32574	177	4	molecular	molecular	ADJ
ajst-32574	177	5	findings	finding	NOUN
ajst-32574	177	6	into	into	ADP
ajst-32574	177	7	functional	functional	ADJ
ajst-32574	177	8	understanding	understanding	NOUN
ajst-32574	177	9	is	be	AUX
ajst-32574	177	10	also	also	ADV
ajst-32574	177	11	essential	essential	ADJ
ajst-32574	177	12	.	.	PUNCT
ajst-32574	178	1	promising	promise	VERB
ajst-32574	178	2	epigenetic	epigenetic	ADJ
ajst-32574	178	3	targets	target	NOUN
ajst-32574	178	4	should	should	AUX
ajst-32574	178	5	be	be	AUX
ajst-32574	178	6	tested	test	VERB
ajst-32574	178	7	in	in	ADP
ajst-32574	178	8	both	both	PRON
ajst-32574	178	9	cell	cell	NOUN
ajst-32574	178	10	and	and	CCONJ
ajst-32574	178	11	animal	animal	NOUN
ajst-32574	178	12	models	model	NOUN
ajst-32574	178	13	,	,	PUNCT
ajst-32574	178	14	and	and	CCONJ
ajst-32574	178	15	techniques	technique	NOUN
ajst-32574	178	16	such	such	ADJ
ajst-32574	178	17	as	as	ADP
ajst-32574	178	18	targeted	target	VERB
ajst-32574	178	19	epigenetic	epigenetic	ADJ
ajst-32574	178	20	editing	editing	NOUN
ajst-32574	178	21	or	or	CCONJ
ajst-32574	178	22	pharmacologic	pharmacologic	ADJ
ajst-32574	178	23	intervention	intervention	NOUN
ajst-32574	178	24	can	can	AUX
ajst-32574	178	25	be	be	AUX
ajst-32574	178	26	used	use	VERB
ajst-32574	178	27	to	to	PART
ajst-32574	178	28	confirm	confirm	VERB
ajst-32574	178	29	their	their	PRON
ajst-32574	178	30	causal	causal	ADJ
ajst-32574	178	31	relation	relation	NOUN
ajst-32574	178	32	.	.	PUNCT
ajst-32574	179	1	focusing	focus	VERB
ajst-32574	179	2	on	on	ADP
ajst-32574	179	3	longitudinal	longitudinal	ADJ
ajst-32574	179	4	studies	study	NOUN
ajst-32574	179	5	,	,	PUNCT
ajst-32574	179	6	multi	multi	ADJ
ajst-32574	179	7	-	-	ADJ
ajst-32574	179	8	omics	omics	ADJ
ajst-32574	179	9	integration	integration	NOUN
ajst-32574	179	10	,	,	PUNCT
ajst-32574	179	11	and	and	CCONJ
ajst-32574	179	12	functional	functional	ADJ
ajst-32574	179	13	validation	validation	NOUN
ajst-32574	179	14	together	together	ADV
ajst-32574	179	15	provides	provide	VERB
ajst-32574	179	16	a	a	DET
ajst-32574	179	17	clear	clear	ADJ
ajst-32574	179	18	direction	direction	NOUN
ajst-32574	179	19	for	for	ADP
ajst-32574	179	20	turning	turn	VERB
ajst-32574	179	21	associative	associative	ADJ
ajst-32574	179	22	results	result	NOUN
ajst-32574	179	23	into	into	ADP
ajst-32574	179	24	real	real	ADV
ajst-32574	179	25	mechanistic	mechanistic	ADJ
ajst-32574	179	26	and	and	CCONJ
ajst-32574	179	27	clinically	clinically	ADV
ajst-32574	179	28	useful	useful	ADJ
ajst-32574	179	29	insights	insight	NOUN
ajst-32574	179	30	in	in	ADP
ajst-32574	179	31	t1d	t1d	PROPN
ajst-32574	179	32	research	research	NOUN
ajst-32574	179	33	.	.	PUNCT
ajst-32574	180	1	future	future	ADJ
ajst-32574	180	2	progress	progress	NOUN
ajst-32574	180	3	in	in	ADP
ajst-32574	180	4	this	this	DET
ajst-32574	180	5	field	field	NOUN
ajst-32574	180	6	depends	depend	VERB
ajst-32574	180	7	on	on	ADP
ajst-32574	180	8	turning	turn	VERB
ajst-32574	180	9	molecular	molecular	ADJ
ajst-32574	180	10	discoveries	discovery	NOUN
ajst-32574	180	11	into	into	ADP
ajst-32574	180	12	practical	practical	ADJ
ajst-32574	180	13	biomarkers	biomarker	NOUN
ajst-32574	180	14	and	and	CCONJ
ajst-32574	180	15	treatments	treatment	NOUN
ajst-32574	180	16	.	.	PUNCT
ajst-32574	181	1	finding	find	VERB
ajst-32574	181	2	reliable	reliable	ADJ
ajst-32574	181	3	early	early	ADJ
ajst-32574	181	4	-	-	PUNCT
ajst-32574	181	5	stage	stage	NOUN
ajst-32574	181	6	biomarkers	biomarker	NOUN
ajst-32574	181	7	is	be	AUX
ajst-32574	181	8	especially	especially	ADV
ajst-32574	181	9	important	important	ADJ
ajst-32574	181	10	for	for	ADP
ajst-32574	181	11	predicting	predict	VERB
ajst-32574	181	12	risk	risk	NOUN
ajst-32574	181	13	,	,	PUNCT
ajst-32574	181	14	211	211	NUM
ajst-32574	181	15	tracking	tracking	NOUN
ajst-32574	181	16	disease	disease	NOUN
ajst-32574	181	17	progression	progression	NOUN
ajst-32574	181	18	,	,	PUNCT
ajst-32574	181	19	and	and	CCONJ
ajst-32574	181	20	evaluating	evaluate	VERB
ajst-32574	181	21	the	the	DET
ajst-32574	181	22	basic	basic	ADJ
ajst-32574	181	23	mechanism	mechanism	NOUN
ajst-32574	181	24	of	of	ADP
ajst-32574	181	25	therapies	therapy	NOUN
ajst-32574	181	26	.	.	PUNCT
ajst-32574	182	1	as	as	SCONJ
ajst-32574	182	2	indicated	indicate	VERB
ajst-32574	182	3	by	by	ADP
ajst-32574	182	4	fyvie	fyvie	NOUN
ajst-32574	182	5	and	and	CCONJ
ajst-32574	182	6	gillespie	gillespie	NOUN
ajst-32574	183	1	[	[	X
ajst-32574	183	2	33	33	NUM
ajst-32574	183	3	]	]	PUNCT
ajst-32574	183	4	,	,	PUNCT
ajst-32574	183	5	biomarker	biomarker	NOUN
ajst-32574	183	6	panels	panel	NOUN
ajst-32574	183	7	that	that	PRON
ajst-32574	183	8	combine	combine	VERB
ajst-32574	183	9	genomic	genomic	ADJ
ajst-32574	183	10	,	,	PUNCT
ajst-32574	183	11	epigenomic	epigenomic	ADJ
ajst-32574	183	12	,	,	PUNCT
ajst-32574	183	13	transcriptomic	transcriptomic	ADJ
ajst-32574	183	14	,	,	PUNCT
ajst-32574	183	15	and	and	CCONJ
ajst-32574	183	16	metabolic	metabolic	NOUN
ajst-32574	183	17	data	datum	NOUN
ajst-32574	183	18	could	could	AUX
ajst-32574	183	19	detect	detect	VERB
ajst-32574	183	20	molecular	molecular	ADJ
ajst-32574	183	21	changes	change	NOUN
ajst-32574	183	22	that	that	PRON
ajst-32574	183	23	occur	occur	VERB
ajst-32574	183	24	before	before	SCONJ
ajst-32574	183	25	symptoms	symptom	NOUN
ajst-32574	183	26	appear	appear	VERB
ajst-32574	183	27	,	,	PUNCT
ajst-32574	183	28	thereby	thereby	ADV
ajst-32574	183	29	enabling	enable	VERB
ajst-32574	183	30	earlier	early	ADV
ajst-32574	183	31	and	and	CCONJ
ajst-32574	183	32	more	more	ADV
ajst-32574	183	33	precise	precise	ADJ
ajst-32574	183	34	disease	disease	NOUN
ajst-32574	183	35	staging	staging	NOUN
ajst-32574	183	36	.	.	PUNCT
ajst-32574	184	1	equally	equally	ADV
ajst-32574	184	2	important	important	ADJ
ajst-32574	184	3	is	be	AUX
ajst-32574	184	4	the	the	DET
ajst-32574	184	5	transition	transition	NOUN
ajst-32574	184	6	from	from	ADP
ajst-32574	184	7	association	association	NOUN
ajst-32574	184	8	studies	study	NOUN
ajst-32574	184	9	toward	toward	ADP
ajst-32574	184	10	causal	causal	ADJ
ajst-32574	184	11	and	and	CCONJ
ajst-32574	184	12	mechanistic	mechanistic	ADJ
ajst-32574	184	13	research	research	NOUN
ajst-32574	184	14	.	.	PUNCT
ajst-32574	185	1	combining	combine	VERB
ajst-32574	185	2	longitudinal	longitudinal	ADJ
ajst-32574	185	3	designs	design	NOUN
ajst-32574	185	4	with	with	ADP
ajst-32574	185	5	multi	multi	ADJ
ajst-32574	185	6	-	-	ADJ
ajst-32574	185	7	omics	omics	ADJ
ajst-32574	185	8	analysis	analysis	NOUN
ajst-32574	185	9	can	can	AUX
ajst-32574	185	10	not	not	PART
ajst-32574	185	11	only	only	ADV
ajst-32574	185	12	clarify	clarify	VERB
ajst-32574	185	13	how	how	SCONJ
ajst-32574	185	14	environmental	environmental	ADJ
ajst-32574	185	15	exposures	exposure	NOUN
ajst-32574	185	16	and	and	CCONJ
ajst-32574	185	17	epigenetic	epigenetic	ADJ
ajst-32574	185	18	regulation	regulation	NOUN
ajst-32574	185	19	contribute	contribute	VERB
ajst-32574	185	20	to	to	ADP
ajst-32574	185	21	autoimmunity	autoimmunity	NOUN
ajst-32574	185	22	but	but	CCONJ
ajst-32574	185	23	also	also	ADV
ajst-32574	185	24	reveal	reveal	VERB
ajst-32574	185	25	modifiable	modifiable	ADJ
ajst-32574	185	26	nodes	node	NOUN
ajst-32574	185	27	for	for	ADP
ajst-32574	185	28	intervention	intervention	NOUN
ajst-32574	185	29	.	.	PUNCT
ajst-32574	186	1	understanding	understand	VERB
ajst-32574	186	2	these	these	DET
ajst-32574	186	3	mechanisms	mechanism	NOUN
ajst-32574	186	4	will	will	AUX
ajst-32574	186	5	also	also	ADV
ajst-32574	186	6	support	support	VERB
ajst-32574	186	7	the	the	DET
ajst-32574	186	8	development	development	NOUN
ajst-32574	186	9	of	of	ADP
ajst-32574	186	10	new	new	ADJ
ajst-32574	186	11	drugs	drug	NOUN
ajst-32574	186	12	and	and	CCONJ
ajst-32574	186	13	diagnostic	diagnostic	ADJ
ajst-32574	186	14	innovations	innovation	NOUN
ajst-32574	186	15	,	,	PUNCT
ajst-32574	186	16	for	for	ADP
ajst-32574	186	17	instance	instance	NOUN
ajst-32574	186	18	,	,	PUNCT
ajst-32574	186	19	by	by	ADP
ajst-32574	186	20	finding	find	VERB
ajst-32574	186	21	molecular	molecular	ADJ
ajst-32574	186	22	targets	target	NOUN
ajst-32574	186	23	that	that	PRON
ajst-32574	186	24	could	could	AUX
ajst-32574	186	25	prevent	prevent	VERB
ajst-32574	186	26	β	β	NOUN
ajst-32574	186	27	-	-	ADJ
ajst-32574	186	28	cell	cell	NOUN
ajst-32574	186	29	destruction	destruction	NOUN
ajst-32574	186	30	or	or	CCONJ
ajst-32574	186	31	slow	slow	ADJ
ajst-32574	186	32	disease	disease	NOUN
ajst-32574	186	33	progression	progression	NOUN
ajst-32574	186	34	.	.	PUNCT
ajst-32574	187	1	furthermore	furthermore	ADV
ajst-32574	187	2	,	,	PUNCT
ajst-32574	187	3	achieving	achieve	VERB
ajst-32574	187	4	these	these	DET
ajst-32574	187	5	goals	goal	NOUN
ajst-32574	187	6	will	will	AUX
ajst-32574	187	7	require	require	VERB
ajst-32574	187	8	broad	broad	ADJ
ajst-32574	187	9	collaboration	collaboration	NOUN
ajst-32574	187	10	and	and	CCONJ
ajst-32574	187	11	the	the	DET
ajst-32574	187	12	development	development	NOUN
ajst-32574	187	13	of	of	ADP
ajst-32574	187	14	ethically	ethically	ADV
ajst-32574	187	15	responsible	responsible	ADJ
ajst-32574	187	16	research	research	NOUN
ajst-32574	187	17	infrastructures	infrastructure	NOUN
ajst-32574	187	18	.	.	PUNCT
ajst-32574	188	1	large	large	ADJ
ajst-32574	188	2	,	,	PUNCT
ajst-32574	188	3	multi	multi	ADJ
ajst-32574	188	4	-	-	ADJ
ajst-32574	188	5	center	center	ADJ
ajst-32574	188	6	studies	study	NOUN
ajst-32574	188	7	with	with	ADP
ajst-32574	188	8	standardized	standardized	ADJ
ajst-32574	188	9	methods	method	NOUN
ajst-32574	188	10	,	,	PUNCT
ajst-32574	188	11	open	open	ADJ
ajst-32574	188	12	data	datum	NOUN
ajst-32574	188	13	sharing	sharing	NOUN
ajst-32574	188	14	,	,	PUNCT
ajst-32574	188	15	and	and	CCONJ
ajst-32574	188	16	strong	strong	ADJ
ajst-32574	188	17	ethical	ethical	ADJ
ajst-32574	188	18	review	review	NOUN
ajst-32574	188	19	are	be	AUX
ajst-32574	188	20	essential	essential	ADJ
ajst-32574	188	21	to	to	PART
ajst-32574	188	22	ensure	ensure	VERB
ajst-32574	188	23	reproducibility	reproducibility	NOUN
ajst-32574	188	24	and	and	CCONJ
ajst-32574	188	25	safety	safety	NOUN
ajst-32574	188	26	.	.	PUNCT
ajst-32574	189	1	collectively	collectively	ADV
ajst-32574	189	2	,	,	PUNCT
ajst-32574	189	3	these	these	DET
ajst-32574	189	4	efforts	effort	NOUN
ajst-32574	189	5	can	can	AUX
ajst-32574	189	6	accelerate	accelerate	VERB
ajst-32574	189	7	the	the	DET
ajst-32574	189	8	shift	shift	NOUN
ajst-32574	189	9	from	from	ADP
ajst-32574	189	10	descriptive	descriptive	ADJ
ajst-32574	189	11	association	association	NOUN
ajst-32574	189	12	studies	study	NOUN
ajst-32574	189	13	toward	toward	ADP
ajst-32574	189	14	building	build	VERB
ajst-32574	189	15	a	a	DET
ajst-32574	189	16	mechanistic	mechanistic	ADJ
ajst-32574	189	17	foundation	foundation	NOUN
ajst-32574	189	18	for	for	ADP
ajst-32574	189	19	prevention	prevention	NOUN
ajst-32574	189	20	and	and	CCONJ
ajst-32574	189	21	therapy	therapy	NOUN
ajst-32574	189	22	.	.	PUNCT
ajst-32574	190	1	5	5	X
ajst-32574	190	2	.	.	X
ajst-32574	190	3	conclusion	conclusion	NOUN
ajst-32574	190	4	type	type	NOUN
ajst-32574	190	5	1	1	NUM
ajst-32574	190	6	diabetes	diabetes	NOUN
ajst-32574	190	7	arises	arise	VERB
ajst-32574	190	8	from	from	ADP
ajst-32574	190	9	a	a	DET
ajst-32574	190	10	multifactorial	multifactorial	ADJ
ajst-32574	190	11	interplay	interplay	NOUN
ajst-32574	190	12	of	of	ADP
ajst-32574	190	13	genetic	genetic	ADJ
ajst-32574	190	14	predisposition	predisposition	NOUN
ajst-32574	190	15	,	,	PUNCT
ajst-32574	190	16	environmental	environmental	ADJ
ajst-32574	190	17	exposures	exposure	NOUN
ajst-32574	190	18	,	,	PUNCT
ajst-32574	190	19	and	and	CCONJ
ajst-32574	190	20	epigenetic	epigenetic	ADJ
ajst-32574	190	21	regulation	regulation	NOUN
ajst-32574	190	22	.	.	PUNCT
ajst-32574	191	1	this	this	DET
ajst-32574	191	2	review	review	NOUN
ajst-32574	191	3	highlights	highlight	VERB
ajst-32574	191	4	how	how	SCONJ
ajst-32574	191	5	vitamin	vitamin	NOUN
ajst-32574	191	6	d	d	NOUN
ajst-32574	191	7	deficiency	deficiency	NOUN
ajst-32574	191	8	and	and	CCONJ
ajst-32574	191	9	enterovirus	enterovirus	NOUN
ajst-32574	191	10	infection	infection	NOUN
ajst-32574	191	11	,	,	PUNCT
ajst-32574	191	12	two	two	NUM
ajst-32574	191	13	prototypical	prototypical	ADJ
ajst-32574	191	14	environmental	environmental	ADJ
ajst-32574	191	15	triggers	trigger	NOUN
ajst-32574	191	16	,	,	PUNCT
ajst-32574	191	17	shape	shape	VERB
ajst-32574	191	18	immune	immune	ADJ
ajst-32574	191	19	tolerance	tolerance	NOUN
ajst-32574	191	20	and	and	CCONJ
ajst-32574	191	21	β	β	NOUN
ajst-32574	191	22	-	-	NOUN
ajst-32574	191	23	cell	cell	NOUN
ajst-32574	191	24	vulnerability	vulnerability	NOUN
ajst-32574	191	25	through	through	ADP
ajst-32574	191	26	immunological	immunological	ADJ
ajst-32574	191	27	and	and	CCONJ
ajst-32574	191	28	molecular	molecular	ADJ
ajst-32574	191	29	pathways	pathway	NOUN
ajst-32574	191	30	.	.	PUNCT
ajst-32574	192	1	although	although	SCONJ
ajst-32574	192	2	vitamin	vitamin	NOUN
ajst-32574	192	3	d	d	NOUN
ajst-32574	192	4	is	be	AUX
ajst-32574	192	5	more	more	ADV
ajst-32574	192	6	closely	closely	ADV
ajst-32574	192	7	associated	associate	VERB
ajst-32574	192	8	epidemiologically	epidemiologically	NOUN
ajst-32574	192	9	and	and	CCONJ
ajst-32574	192	10	enteroviruses	enterovirus	NOUN
ajst-32574	192	11	show	show	VERB
ajst-32574	192	12	stronger	strong	ADJ
ajst-32574	192	13	causal	causal	ADJ
ajst-32574	192	14	evidence	evidence	NOUN
ajst-32574	192	15	,	,	PUNCT
ajst-32574	192	16	both	both	PRON
ajst-32574	192	17	ultimately	ultimately	ADV
ajst-32574	192	18	point	point	VERB
ajst-32574	192	19	toward	toward	ADP
ajst-32574	192	20	the	the	DET
ajst-32574	192	21	same	same	ADJ
ajst-32574	192	22	principle	principle	NOUN
ajst-32574	192	23	that	that	SCONJ
ajst-32574	192	24	environmental	environmental	ADJ
ajst-32574	192	25	stimuli	stimulus	NOUN
ajst-32574	192	26	can	can	AUX
ajst-32574	192	27	reprogram	reprogram	VERB
ajst-32574	192	28	immune	immune	ADJ
ajst-32574	192	29	and	and	CCONJ
ajst-32574	192	30	metabolic	metabolic	NOUN
ajst-32574	192	31	networks	network	NOUN
ajst-32574	192	32	beyond	beyond	ADP
ajst-32574	192	33	the	the	DET
ajst-32574	192	34	genome	genome	NOUN
ajst-32574	192	35	itself	itself	PRON
ajst-32574	192	36	.	.	PUNCT
ajst-32574	193	1	epigenetic	epigenetic	ADJ
ajst-32574	193	2	research	research	NOUN
ajst-32574	193	3	has	have	AUX
ajst-32574	193	4	revealed	reveal	VERB
ajst-32574	193	5	that	that	SCONJ
ajst-32574	193	6	dna	dna	PROPN
ajst-32574	193	7	methylation	methylation	NOUN
ajst-32574	193	8	,	,	PUNCT
ajst-32574	193	9	histone	histone	NOUN
ajst-32574	193	10	modification	modification	NOUN
ajst-32574	193	11	,	,	PUNCT
ajst-32574	193	12	and	and	CCONJ
ajst-32574	193	13	non	non	ADJ
ajst-32574	193	14	-	-	ADJ
ajst-32574	193	15	coding	coding	ADJ
ajst-32574	193	16	rna	rna	NOUN
ajst-32574	193	17	dysregulation	dysregulation	NOUN
ajst-32574	193	18	form	form	NOUN
ajst-32574	193	19	the	the	DET
ajst-32574	193	20	molecular	molecular	ADJ
ajst-32574	193	21	bridge	bridge	NOUN
ajst-32574	193	22	,	,	PUNCT
ajst-32574	193	23	connecting	connect	VERB
ajst-32574	193	24	these	these	DET
ajst-32574	193	25	exposures	exposure	NOUN
ajst-32574	193	26	with	with	ADP
ajst-32574	193	27	autoimmune	autoimmune	ADJ
ajst-32574	193	28	pathogenesis	pathogenesis	NOUN
ajst-32574	193	29	.	.	PUNCT
ajst-32574	194	1	longitudinal	longitudinal	ADJ
ajst-32574	194	2	and	and	CCONJ
ajst-32574	194	3	twin	twin	ADJ
ajst-32574	194	4	studies	study	NOUN
ajst-32574	194	5	further	far	ADV
ajst-32574	194	6	indicate	indicate	VERB
ajst-32574	194	7	that	that	SCONJ
ajst-32574	194	8	such	such	ADJ
ajst-32574	194	9	epigenetic	epigenetic	ADJ
ajst-32574	194	10	signatures	signature	NOUN
ajst-32574	194	11	may	may	AUX
ajst-32574	194	12	precede	precede	VERB
ajst-32574	194	13	clinical	clinical	ADJ
ajst-32574	194	14	onset	onset	NOUN
ajst-32574	194	15	,	,	PUNCT
ajst-32574	194	16	suggesting	suggest	VERB
ajst-32574	194	17	their	their	PRON
ajst-32574	194	18	potential	potential	NOUN
ajst-32574	194	19	as	as	ADP
ajst-32574	194	20	predictive	predictive	ADJ
ajst-32574	194	21	biomarkers	biomarker	NOUN
ajst-32574	194	22	.	.	PUNCT
ajst-32574	195	1	nevertheless	nevertheless	ADV
ajst-32574	195	2	,	,	PUNCT
ajst-32574	195	3	most	most	ADJ
ajst-32574	195	4	current	current	ADJ
ajst-32574	195	5	studies	study	NOUN
ajst-32574	195	6	remain	remain	VERB
ajst-32574	195	7	fragmentary	fragmentary	ADJ
ajst-32574	195	8	,	,	PUNCT
ajst-32574	195	9	often	often	ADV
ajst-32574	195	10	limited	limit	VERB
ajst-32574	195	11	to	to	ADP
ajst-32574	195	12	single	single	ADJ
ajst-32574	195	13	-	-	PUNCT
ajst-32574	195	14	layer	layer	NOUN
ajst-32574	195	15	analyses	analysis	NOUN
ajst-32574	195	16	.	.	PUNCT
ajst-32574	196	1	integrative	integrative	ADJ
ajst-32574	196	2	multi	multi	ADJ
ajst-32574	196	3	-	-	ADJ
ajst-32574	196	4	omics	omics	ADJ
ajst-32574	196	5	approaches	approach	NOUN
ajst-32574	196	6	that	that	PRON
ajst-32574	196	7	link	link	VERB
ajst-32574	196	8	genome	genome	NOUN
ajst-32574	196	9	,	,	PUNCT
ajst-32574	196	10	epigenome	epigenome	NOUN
ajst-32574	196	11	,	,	PUNCT
ajst-32574	196	12	transcriptome	transcriptome	NOUN
ajst-32574	196	13	,	,	PUNCT
ajst-32574	196	14	and	and	CCONJ
ajst-32574	196	15	metabolome	metabolome	NOUN
ajst-32574	196	16	will	will	AUX
ajst-32574	196	17	be	be	AUX
ajst-32574	196	18	essential	essential	ADJ
ajst-32574	196	19	to	to	PART
ajst-32574	196	20	delineate	delineate	VERB
ajst-32574	196	21	causal	causal	ADJ
ajst-32574	196	22	cascades	cascade	NOUN
ajst-32574	196	23	and	and	CCONJ
ajst-32574	196	24	identify	identify	VERB
ajst-32574	196	25	actionable	actionable	ADJ
ajst-32574	196	26	molecular	molecular	ADJ
ajst-32574	196	27	nodes	node	NOUN
ajst-32574	196	28	.	.	PUNCT
ajst-32574	197	1	in	in	ADP
ajst-32574	197	2	summary	summary	NOUN
ajst-32574	197	3	,	,	PUNCT
ajst-32574	197	4	understanding	understand	VERB
ajst-32574	197	5	the	the	DET
ajst-32574	197	6	mechanisms	mechanism	NOUN
ajst-32574	197	7	by	by	ADP
ajst-32574	197	8	which	which	PRON
ajst-32574	197	9	environmental	environmental	ADJ
ajst-32574	197	10	and	and	CCONJ
ajst-32574	197	11	epigenetic	epigenetic	ADJ
ajst-32574	197	12	factors	factor	NOUN
ajst-32574	197	13	shape	shape	VERB
ajst-32574	197	14	immune	immune	ADJ
ajst-32574	197	15	tolerance	tolerance	NOUN
ajst-32574	197	16	and	and	CCONJ
ajst-32574	197	17	β	β	NOUN
ajst-32574	197	18	-	-	NOUN
ajst-32574	197	19	cell	cell	NOUN
ajst-32574	197	20	resilience	resilience	NOUN
ajst-32574	197	21	represents	represent	VERB
ajst-32574	197	22	a	a	DET
ajst-32574	197	23	significant	significant	ADJ
ajst-32574	197	24	step	step	NOUN
ajst-32574	197	25	toward	toward	ADP
ajst-32574	197	26	uncovering	uncover	VERB
ajst-32574	197	27	the	the	DET
ajst-32574	197	28	mechanisms	mechanism	NOUN
ajst-32574	197	29	of	of	ADP
ajst-32574	197	30	t1d	t1d	PROPN
ajst-32574	197	31	.	.	PUNCT
ajst-32574	198	1	integrating	integrate	VERB
ajst-32574	198	2	longitudinal	longitudinal	ADJ
ajst-32574	198	3	and	and	CCONJ
ajst-32574	198	4	multi	multi	ADJ
ajst-32574	198	5	-	-	ADJ
ajst-32574	198	6	omics	omic	NOUN
ajst-32574	198	7	studies	study	NOUN
ajst-32574	198	8	will	will	AUX
ajst-32574	198	9	not	not	PART
ajst-32574	198	10	only	only	ADV
ajst-32574	198	11	advance	advance	VERB
ajst-32574	198	12	mechanistic	mechanistic	ADJ
ajst-32574	198	13	insight	insight	NOUN
ajst-32574	198	14	but	but	CCONJ
ajst-32574	198	15	also	also	ADV
ajst-32574	198	16	support	support	VERB
ajst-32574	198	17	the	the	DET
ajst-32574	198	18	development	development	NOUN
ajst-32574	198	19	of	of	ADP
ajst-32574	198	20	predictive	predictive	ADJ
ajst-32574	198	21	biomarkers	biomarker	NOUN
ajst-32574	198	22	and	and	CCONJ
ajst-32574	198	23	targeted	target	VERB
ajst-32574	198	24	preventive	preventive	ADJ
ajst-32574	198	25	strategies	strategy	NOUN
ajst-32574	198	26	for	for	ADP
ajst-32574	198	27	this	this	DET
ajst-32574	198	28	autoimmune	autoimmune	ADJ
ajst-32574	198	29	disease	disease	NOUN
ajst-32574	198	30	.	.	PUNCT
ajst-32574	199	1	references	reference	NOUN
ajst-32574	199	2	[	[	X
ajst-32574	199	3	1	1	NUM
ajst-32574	199	4	]	]	X
ajst-32574	199	5	noble	noble	ADJ
ajst-32574	199	6	,	,	PUNCT
ajst-32574	199	7	janelle	janelle	PROPN
ajst-32574	199	8	a.	a.	NOUN
ajst-32574	199	9	“	"	PUNCT
ajst-32574	199	10	fifty	fifty	NUM
ajst-32574	199	11	years	year	NOUN
ajst-32574	199	12	of	of	ADP
ajst-32574	199	13	hla	hla	NOUN
ajst-32574	199	14	-	-	PUNCT
ajst-32574	199	15	associated	associate	VERB
ajst-32574	199	16	type	type	NOUN
ajst-32574	199	17	1	1	NUM
ajst-32574	199	18	diabetes	diabetes	NOUN
ajst-32574	199	19	risk	risk	NOUN
ajst-32574	199	20	:	:	PUNCT
ajst-32574	199	21	history	history	NOUN
ajst-32574	199	22	,	,	PUNCT
ajst-32574	199	23	current	current	ADJ
ajst-32574	199	24	knowledge	knowledge	NOUN
ajst-32574	199	25	,	,	PUNCT
ajst-32574	199	26	and	and	CCONJ
ajst-32574	199	27	future	future	ADJ
ajst-32574	199	28	directions	direction	NOUN
ajst-32574	199	29	.	.	PUNCT
ajst-32574	199	30	”	"	PUNCT
ajst-32574	200	1	frontiers	frontier	NOUN
ajst-32574	200	2	in	in	ADP
ajst-32574	200	3	immunology	immunology	NOUN
ajst-32574	200	4	15	15	NUM
ajst-32574	200	5	(	(	PUNCT
ajst-32574	200	6	2024	2024	NUM
ajst-32574	200	7	):	):	PUNCT
ajst-32574	200	8	1457213	1457213	NUM
ajst-32574	200	9	.	.	PUNCT
ajst-32574	201	1	https://doi.org/	https://doi.org/	NOUN
ajst-32574	201	2	10	10	NUM
ajst-32574	201	3	.	.	PUNCT
ajst-32574	202	1	3389/	3389/	NUM
ajst-32574	202	2	fimmu	fimmu	NOUN
ajst-32574	202	3	.	.	PUNCT
ajst-32574	203	1	2024	2024	NUM
ajst-32574	203	2	.	.	PUNCT
ajst-32574	204	1	1457213	1457213	NUM
ajst-32574	204	2	.	.	PUNCT
ajst-32574	205	1	[	[	X
ajst-32574	205	2	2	2	NUM
ajst-32574	205	3	]	]	X
ajst-32574	205	4	noble	noble	ADJ
ajst-32574	205	5	,	,	PUNCT
ajst-32574	205	6	janelle	janelle	PROPN
ajst-32574	205	7	a.	a.	NOUN
ajst-32574	205	8	,	,	PUNCT
ajst-32574	205	9	and	and	CCONJ
ajst-32574	205	10	ana	ana	PROPN
ajst-32574	205	11	m.	m.	NOUN
ajst-32574	205	12	valdes	valde	NOUN
ajst-32574	205	13	.	.	PUNCT
ajst-32574	206	1	“	"	PUNCT
ajst-32574	206	2	genetics	genetic	NOUN
ajst-32574	206	3	of	of	ADP
ajst-32574	206	4	the	the	DET
ajst-32574	206	5	hla	hla	PROPN
ajst-32574	206	6	region	region	NOUN
ajst-32574	206	7	in	in	ADP
ajst-32574	206	8	the	the	DET
ajst-32574	206	9	prediction	prediction	NOUN
ajst-32574	206	10	of	of	ADP
ajst-32574	206	11	type	type	NOUN
ajst-32574	206	12	1	1	NUM
ajst-32574	206	13	diabetes	diabetes	NOUN
ajst-32574	206	14	.	.	PUNCT
ajst-32574	206	15	”	"	PUNCT
ajst-32574	207	1	current	current	ADJ
ajst-32574	207	2	diabetes	diabetes	NOUN
ajst-32574	207	3	reports	report	VERB
ajst-32574	207	4	11	11	NUM
ajst-32574	207	5	,	,	PUNCT
ajst-32574	207	6	no	no	INTJ
ajst-32574	207	7	.	.	NOUN
ajst-32574	207	8	6	6	NUM
ajst-32574	207	9	(	(	PUNCT
ajst-32574	207	10	2011	2011	NUM
ajst-32574	207	11	):	):	PUNCT
ajst-32574	207	12	533–42	533–42	NUM
ajst-32574	207	13	.	.	PUNCT
ajst-32574	208	1	https://doi.org/10.1007/s11892-011-0223-x	https://doi.org/10.1007/s11892-011-0223-x	NOUN
ajst-32574	208	2	.	.	PUNCT
ajst-32574	209	1	[	[	X
ajst-32574	209	2	3	3	NUM
ajst-32574	209	3	]	]	X
ajst-32574	209	4	jerram	jerram	PROPN
ajst-32574	209	5	,	,	PUNCT
ajst-32574	209	6	samuel	samuel	PROPN
ajst-32574	209	7	t.	t.	PROPN
ajst-32574	209	8	,	,	PUNCT
ajst-32574	209	9	and	and	CCONJ
ajst-32574	209	10	richard	richard	PROPN
ajst-32574	209	11	david	david	PROPN
ajst-32574	209	12	leslie	leslie	PROPN
ajst-32574	209	13	.	.	PUNCT
ajst-32574	210	1	“	"	PUNCT
ajst-32574	210	2	the	the	DET
ajst-32574	210	3	genetic	genetic	ADJ
ajst-32574	210	4	architecture	architecture	NOUN
ajst-32574	210	5	of	of	ADP
ajst-32574	210	6	type	type	NOUN
ajst-32574	210	7	1	1	NUM
ajst-32574	210	8	diabetes	diabetes	NOUN
ajst-32574	210	9	.	.	PUNCT
ajst-32574	210	10	”	"	PUNCT
ajst-32574	211	1	genes	gene	NOUN
ajst-32574	211	2	8	8	NUM
ajst-32574	211	3	,	,	PUNCT
ajst-32574	211	4	no	no	INTJ
ajst-32574	211	5	.	.	NOUN
ajst-32574	211	6	8	8	NUM
ajst-32574	211	7	(	(	PUNCT
ajst-32574	211	8	2017	2017	NUM
ajst-32574	211	9	):	):	PUNCT
ajst-32574	211	10	209	209	NUM
ajst-32574	211	11	.	.	PUNCT
ajst-32574	212	1	https://doi.org/10.3390/genes8080209	https://doi.org/10.3390/genes8080209	ADJ
ajst-32574	212	2	.	.	PUNCT
ajst-32574	213	1	[	[	X
ajst-32574	213	2	4	4	NUM
ajst-32574	213	3	]	]	PUNCT
ajst-32574	213	4	triolo	triolo	NOUN
ajst-32574	213	5	,	,	PUNCT
ajst-32574	213	6	taylor	taylor	PROPN
ajst-32574	213	7	m.	m.	NOUN
ajst-32574	213	8	,	,	PUNCT
ajst-32574	213	9	alexandra	alexandra	PROPN
ajst-32574	213	10	fouts	fouts	PROPN
ajst-32574	213	11	,	,	PUNCT
ajst-32574	213	12	laura	laura	PROPN
ajst-32574	213	13	pyle	pyle	PROPN
ajst-32574	213	14	,	,	PUNCT
ajst-32574	213	15	liping	liping	PROPN
ajst-32574	213	16	yu	yu	PROPN
ajst-32574	213	17	,	,	PUNCT
ajst-32574	213	18	peter	peter	PROPN
ajst-32574	213	19	a.	a.	PROPN
ajst-32574	213	20	gottlieb	gottlieb	PROPN
ajst-32574	213	21	,	,	PUNCT
ajst-32574	213	22	and	and	CCONJ
ajst-32574	213	23	andrea	andrea	PROPN
ajst-32574	213	24	k.	k.	PROPN
ajst-32574	213	25	steck	steck	PROPN
ajst-32574	213	26	.	.	PUNCT
ajst-32574	214	1	“	"	PUNCT
ajst-32574	214	2	identical	identical	ADJ
ajst-32574	214	3	and	and	CCONJ
ajst-32574	214	4	nonidentical	nonidentical	ADJ
ajst-32574	214	5	twins	twin	NOUN
ajst-32574	214	6	:	:	PUNCT
ajst-32574	214	7	risk	risk	NOUN
ajst-32574	214	8	and	and	CCONJ
ajst-32574	214	9	factors	factor	NOUN
ajst-32574	214	10	involved	involve	VERB
ajst-32574	214	11	in	in	ADP
ajst-32574	214	12	development	development	NOUN
ajst-32574	214	13	of	of	ADP
ajst-32574	214	14	islet	islet	NOUN
ajst-32574	214	15	autoimmunity	autoimmunity	NOUN
ajst-32574	214	16	and	and	CCONJ
ajst-32574	214	17	type	type	NOUN
ajst-32574	214	18	1	1	NUM
ajst-32574	214	19	diabetes	diabetes	NOUN
ajst-32574	214	20	.	.	PUNCT
ajst-32574	214	21	”	"	PUNCT
ajst-32574	215	1	diabetes	diabete	NOUN
ajst-32574	215	2	care	care	VERB
ajst-32574	215	3	42	42	NUM
ajst-32574	215	4	,	,	PUNCT
ajst-32574	215	5	no	no	INTJ
ajst-32574	215	6	.	.	NOUN
ajst-32574	215	7	2	2	NUM
ajst-32574	215	8	(	(	PUNCT
ajst-32574	215	9	2019	2019	NUM
ajst-32574	215	10	):	):	PUNCT
ajst-32574	215	11	192–99	192–99	NUM
ajst-32574	215	12	.	.	PUNCT
ajst-32574	216	1	https://doi.org/10.2337/dc18-0288	https://doi.org/10.2337/dc18-0288	ADJ
ajst-32574	216	2	.	.	PUNCT
ajst-32574	217	1	[	[	X
ajst-32574	217	2	5	5	NUM
ajst-32574	217	3	]	]	X
ajst-32574	217	4	rewers	rewer	NOUN
ajst-32574	217	5	,	,	PUNCT
ajst-32574	217	6	marian	marian	PROPN
ajst-32574	217	7	,	,	PUNCT
ajst-32574	217	8	daniel	daniel	PROPN
ajst-32574	217	9	agardh	agardh	PROPN
ajst-32574	217	10	,	,	PUNCT
ajst-32574	217	11	suzanne	suzanne	PROPN
ajst-32574	217	12	bennett	bennett	PROPN
ajst-32574	217	13	johnson	johnson	PROPN
ajst-32574	217	14	,	,	PUNCT
ajst-32574	217	15	et	et	PROPN
ajst-32574	217	16	al	al	PROPN
ajst-32574	217	17	.	.	PUNCT
ajst-32574	218	1	“	"	PUNCT
ajst-32574	218	2	unfolding	unfold	VERB
ajst-32574	218	3	the	the	DET
ajst-32574	218	4	mystery	mystery	NOUN
ajst-32574	218	5	of	of	ADP
ajst-32574	218	6	autoimmunity	autoimmunity	NOUN
ajst-32574	218	7	:	:	PUNCT
ajst-32574	218	8	the	the	DET
ajst-32574	218	9	environmental	environmental	ADJ
ajst-32574	218	10	determinants	determinant	NOUN
ajst-32574	218	11	of	of	ADP
ajst-32574	218	12	diabetes	diabetes	NOUN
ajst-32574	218	13	in	in	ADP
ajst-32574	218	14	the	the	DET
ajst-32574	218	15	young	young	ADJ
ajst-32574	218	16	(	(	PUNCT
ajst-32574	218	17	teddy	teddy	PROPN
ajst-32574	218	18	)	)	PUNCT
ajst-32574	218	19	study	study	NOUN
ajst-32574	218	20	.	.	PUNCT
ajst-32574	218	21	”	"	PUNCT
ajst-32574	219	1	diabetes	diabetes	NOUN
ajst-32574	219	2	care	care	VERB
ajst-32574	219	3	48	48	NUM
ajst-32574	219	4	,	,	PUNCT
ajst-32574	219	5	no	no	INTJ
ajst-32574	219	6	.	.	NOUN
ajst-32574	219	7	7	7	NUM
ajst-32574	219	8	(	(	PUNCT
ajst-32574	219	9	2025	2025	NUM
ajst-32574	219	10	):	):	PUNCT
ajst-32574	219	11	1125–35	1125–35	NUM
ajst-32574	219	12	.	.	PUNCT
ajst-32574	220	1	https://doi.org/10.2337/dc24-2886	https://doi.org/10.2337/dc24-2886	PROPN
ajst-32574	220	2	.	.	PUNCT
ajst-32574	221	1	212	212	NUM
ajst-32574	222	1	[	[	SYM
ajst-32574	222	2	6	6	NUM
ajst-32574	222	3	]	]	X
ajst-32574	222	4	minniakhmetov	minniakhmetov	NOUN
ajst-32574	222	5	,	,	PUNCT
ajst-32574	222	6	ildar	ildar	PROPN
ajst-32574	222	7	,	,	PUNCT
ajst-32574	222	8	bulat	bulat	PROPN
ajst-32574	222	9	yalaev	yalaev	PROPN
ajst-32574	222	10	,	,	PUNCT
ajst-32574	222	11	rita	rita	PROPN
ajst-32574	222	12	khusainova	khusainova	PROPN
ajst-32574	222	13	,	,	PUNCT
ajst-32574	222	14	et	et	PROPN
ajst-32574	222	15	al	al	PROPN
ajst-32574	222	16	.	.	PUNCT
ajst-32574	223	1	“	"	PUNCT
ajst-32574	223	2	genetic	genetic	ADJ
ajst-32574	223	3	and	and	CCONJ
ajst-32574	223	4	epigenetic	epigenetic	ADJ
ajst-32574	223	5	aspects	aspect	NOUN
ajst-32574	223	6	of	of	ADP
ajst-32574	223	7	type	type	NOUN
ajst-32574	223	8	1	1	NUM
ajst-32574	223	9	diabetes	diabetes	NOUN
ajst-32574	223	10	mellitus	mellitus	NOUN
ajst-32574	223	11	:	:	PUNCT
ajst-32574	223	12	modern	modern	ADJ
ajst-32574	223	13	view	view	NOUN
ajst-32574	223	14	on	on	ADP
ajst-32574	223	15	the	the	DET
ajst-32574	223	16	problem	problem	NOUN
ajst-32574	223	17	.	.	PUNCT
ajst-32574	223	18	”	"	PUNCT
ajst-32574	223	19	biomedicines	biomedicine	VERB
ajst-32574	223	20	12	12	NUM
ajst-32574	223	21	,	,	PUNCT
ajst-32574	223	22	no	no	INTJ
ajst-32574	223	23	.	.	NOUN
ajst-32574	223	24	2	2	NUM
ajst-32574	223	25	(	(	PUNCT
ajst-32574	223	26	2024	2024	NUM
ajst-32574	223	27	):	):	PUNCT
ajst-32574	223	28	399	399	NUM
ajst-32574	223	29	.	.	PUNCT
ajst-32574	224	1	https://	https://	PROPN
ajst-32574	224	2	doi	doi	PROPN
ajst-32574	224	3	.	.	PUNCT
ajst-32574	225	1	org/	org/	NOUN
ajst-32574	225	2	10.3390	10.3390	NUM
ajst-32574	225	3	/	/	SYM
ajst-32574	225	4	biomedicines12020399	biomedicines12020399	PROPN
ajst-32574	225	5	.	.	PUNCT
ajst-32574	226	1	[	[	X
ajst-32574	226	2	7	7	NUM
ajst-32574	226	3	]	]	SYM
ajst-32574	226	4	yang	yang	PROPN
ajst-32574	226	5	,	,	PUNCT
ajst-32574	226	6	xin	xin	PROPN
ajst-32574	226	7	,	,	PUNCT
ajst-32574	226	8	min	min	NOUN
ajst-32574	226	9	chai	chai	NOUN
ajst-32574	226	10	,	,	PUNCT
ajst-32574	226	11	and	and	CCONJ
ajst-32574	226	12	meng	meng	PROPN
ajst-32574	226	13	lin	lin	PROPN
ajst-32574	226	14	.	.	PUNCT
ajst-32574	227	1	“	"	PUNCT
ajst-32574	227	2	proportion	proportion	NOUN
ajst-32574	227	3	of	of	ADP
ajst-32574	227	4	vitamin	vitamin	NOUN
ajst-32574	227	5	d	d	NOUN
ajst-32574	227	6	deficiency	deficiency	NOUN
ajst-32574	227	7	in	in	ADP
ajst-32574	227	8	children	child	NOUN
ajst-32574	227	9	/	/	SYM
ajst-32574	227	10	adolescents	adolescent	NOUN
ajst-32574	227	11	with	with	ADP
ajst-32574	227	12	type	type	NOUN
ajst-32574	227	13	1	1	NUM
ajst-32574	227	14	diabetes	diabete	NOUN
ajst-32574	227	15	:	:	PUNCT
ajst-32574	227	16	a	a	DET
ajst-32574	227	17	systematic	systematic	ADJ
ajst-32574	227	18	review	review	NOUN
ajst-32574	227	19	and	and	CCONJ
ajst-32574	227	20	meta	meta	ADJ
ajst-32574	227	21	-	-	PUNCT
ajst-32574	227	22	analysis	analysis	NOUN
ajst-32574	227	23	.	.	PUNCT
ajst-32574	227	24	”	"	PUNCT
ajst-32574	228	1	bmc	bmc	ADJ
ajst-32574	228	2	pediatrics	pediatric	NOUN
ajst-32574	228	3	24	24	NUM
ajst-32574	228	4	,	,	PUNCT
ajst-32574	228	5	no	no	INTJ
ajst-32574	228	6	.	.	NOUN
ajst-32574	228	7	1	1	NUM
ajst-32574	228	8	(	(	PUNCT
ajst-32574	228	9	2024	2024	NUM
ajst-32574	228	10	):	):	PUNCT
ajst-32574	228	11	192	192	NUM
ajst-32574	228	12	.	.	PUNCT
ajst-32574	228	13	https://doi.org/10.1186/s12887-024-04683-5	https://doi.org/10.1186/s12887-024-04683-5	NUM
ajst-32574	228	14	.	.	PUNCT
ajst-32574	229	1	[	[	X
ajst-32574	229	2	8	8	NUM
ajst-32574	229	3	]	]	X
ajst-32574	229	4	daskalopoulou	daskalopoulou	NOUN
ajst-32574	229	5	,	,	PUNCT
ajst-32574	229	6	maria	maria	PROPN
ajst-32574	229	7	,	,	PUNCT
ajst-32574	229	8	magdalini	magdalini	VERB
ajst-32574	229	9	pylli	pylli	NOUN
ajst-32574	229	10	,	,	PUNCT
ajst-32574	229	11	and	and	CCONJ
ajst-32574	229	12	konstantinos	konstantinos	PROPN
ajst-32574	229	13	giannakou	giannakou	PROPN
ajst-32574	229	14	.	.	PUNCT
ajst-32574	230	1	“	"	PUNCT
ajst-32574	230	2	vitamin	vitamin	NOUN
ajst-32574	230	3	d	d	NOUN
ajst-32574	230	4	deficiency	deficiency	NOUN
ajst-32574	230	5	as	as	ADP
ajst-32574	230	6	a	a	DET
ajst-32574	230	7	possible	possible	ADJ
ajst-32574	230	8	cause	cause	NOUN
ajst-32574	230	9	of	of	ADP
ajst-32574	230	10	type	type	NOUN
ajst-32574	230	11	1	1	NUM
ajst-32574	230	12	diabetes	diabetes	NOUN
ajst-32574	230	13	in	in	ADP
ajst-32574	230	14	children	child	NOUN
ajst-32574	230	15	and	and	CCONJ
ajst-32574	230	16	adolescents	adolescent	NOUN
ajst-32574	230	17	up	up	ADP
ajst-32574	230	18	to	to	PART
ajst-32574	230	19	15	15	NUM
ajst-32574	230	20	years	year	NOUN
ajst-32574	230	21	old	old	ADJ
ajst-32574	230	22	:	:	PUNCT
ajst-32574	230	23	a	a	DET
ajst-32574	230	24	systematic	systematic	ADJ
ajst-32574	230	25	review	review	NOUN
ajst-32574	230	26	.	.	PUNCT
ajst-32574	230	27	”	"	PUNCT
ajst-32574	231	1	the	the	DET
ajst-32574	231	2	review	review	NOUN
ajst-32574	231	3	of	of	ADP
ajst-32574	231	4	diabetic	diabetic	ADJ
ajst-32574	231	5	studies	study	NOUN
ajst-32574	231	6	:	:	PUNCT
ajst-32574	231	7	rds	rd	VERB
ajst-32574	231	8	18	18	NUM
ajst-32574	231	9	,	,	PUNCT
ajst-32574	231	10	no	no	INTJ
ajst-32574	231	11	.	.	NOUN
ajst-32574	231	12	2	2	NUM
ajst-32574	231	13	(	(	PUNCT
ajst-32574	231	14	2022	2022	NUM
ajst-32574	231	15	):	):	PUNCT
ajst-32574	231	16	58–67	58–67	NUM
ajst-32574	231	17	.	.	PUNCT
ajst-32574	232	1	https://doi.org/10.1900/rds.2022.18.58	https://doi.org/10.1900/rds.2022.18.58	PROPN
ajst-32574	232	2	.	.	PUNCT
ajst-32574	233	1	[	[	X
ajst-32574	233	2	9	9	NUM
ajst-32574	233	3	]	]	SYM
ajst-32574	233	4	nascimento	nascimento	PROPN
ajst-32574	233	5	,	,	PUNCT
ajst-32574	233	6	bárbara	bárbara	PROPN
ajst-32574	233	7	folino	folino	PROPN
ajst-32574	233	8	,	,	PUNCT
ajst-32574	233	9	carolina	carolina	PROPN
ajst-32574	233	10	f.	f.	PROPN
ajst-32574	233	11	f.	f.	PROPN
ajst-32574	233	12	moreira	moreira	PROPN
ajst-32574	233	13	,	,	PUNCT
ajst-32574	233	14	eliana	eliana	PROPN
ajst-32574	233	15	r.	r.	PROPN
ajst-32574	233	16	da	da	PROPN
ajst-32574	233	17	fonseca	fonseca	PROPN
ajst-32574	233	18	,	,	PUNCT
ajst-32574	233	19	et	et	PROPN
ajst-32574	233	20	al	al	PROPN
ajst-32574	233	21	.	.	PUNCT
ajst-32574	234	1	“	"	PUNCT
ajst-32574	234	2	effects	effect	NOUN
ajst-32574	234	3	of	of	ADP
ajst-32574	234	4	vitamin	vitamin	NOUN
ajst-32574	234	5	d	d	NOUN
ajst-32574	234	6	supplementation	supplementation	NOUN
ajst-32574	234	7	on	on	ADP
ajst-32574	234	8	glycemic	glycemic	ADJ
ajst-32574	234	9	control	control	NOUN
ajst-32574	234	10	of	of	ADP
ajst-32574	234	11	children	child	NOUN
ajst-32574	234	12	and	and	CCONJ
ajst-32574	234	13	adolescents	adolescent	NOUN
ajst-32574	234	14	with	with	ADP
ajst-32574	234	15	type	type	NOUN
ajst-32574	234	16	1	1	NUM
ajst-32574	234	17	diabetes	diabetes	NOUN
ajst-32574	234	18	mellitus	mellitus	NOUN
ajst-32574	234	19	:	:	PUNCT
ajst-32574	234	20	a	a	DET
ajst-32574	234	21	systematic	systematic	ADJ
ajst-32574	234	22	review	review	NOUN
ajst-32574	234	23	.	.	PUNCT
ajst-32574	234	24	”	"	PUNCT
ajst-32574	235	1	journal	journal	NOUN
ajst-32574	235	2	of	of	ADP
ajst-32574	235	3	pediatric	pediatric	ADJ
ajst-32574	235	4	endocrinology	endocrinology	NOUN
ajst-32574	235	5	&	&	CCONJ
ajst-32574	235	6	metabolism	metabolism	NOUN
ajst-32574	235	7	:	:	PUNCT
ajst-32574	235	8	jpem	jpem	VERB
ajst-32574	235	9	35	35	NUM
ajst-32574	235	10	,	,	PUNCT
ajst-32574	235	11	no	no	NOUN
ajst-32574	235	12	.	.	NOUN
ajst-32574	235	13	8	8	NUM
ajst-32574	235	14	(	(	PUNCT
ajst-32574	235	15	2022	2022	NUM
ajst-32574	235	16	):	):	PUNCT
ajst-32574	235	17	973–88	973–88	NUM
ajst-32574	235	18	.	.	PUNCT
ajst-32574	236	1	https://doi.org/10.1515/jpem-2022-0044	https://doi.org/10.1515/jpem-2022-0044	PROPN
ajst-32574	236	2	.	.	PUNCT
ajst-32574	237	1	[	[	X
ajst-32574	237	2	10	10	NUM
ajst-32574	237	3	]	]	X
ajst-32574	237	4	manousaki	manousaki	NOUN
ajst-32574	237	5	,	,	PUNCT
ajst-32574	237	6	despoina	despoina	PROPN
ajst-32574	237	7	,	,	PUNCT
ajst-32574	237	8	adil	adil	PROPN
ajst-32574	237	9	harroud	harroud	PROPN
ajst-32574	237	10	,	,	PUNCT
ajst-32574	237	11	ruth	ruth	PROPN
ajst-32574	237	12	e.	e.	PROPN
ajst-32574	237	13	mitchell	mitchell	PROPN
ajst-32574	237	14	,	,	PUNCT
ajst-32574	237	15	et	et	PROPN
ajst-32574	237	16	al	al	PROPN
ajst-32574	237	17	.	.	PUNCT
ajst-32574	238	1	“	"	PUNCT
ajst-32574	238	2	vitamin	vitamin	NOUN
ajst-32574	238	3	d	d	NOUN
ajst-32574	238	4	levels	level	NOUN
ajst-32574	238	5	and	and	CCONJ
ajst-32574	238	6	risk	risk	NOUN
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ajst-32574	238	8	type	type	NOUN
ajst-32574	238	9	1	1	NUM
ajst-32574	238	10	diabetes	diabetes	NOUN
ajst-32574	238	11	:	:	PUNCT
ajst-32574	238	12	a	a	DET
ajst-32574	238	13	mendelian	mendelian	ADJ
ajst-32574	238	14	randomization	randomization	NOUN
ajst-32574	238	15	study	study	NOUN
ajst-32574	238	16	.	.	PUNCT
ajst-32574	238	17	”	"	PUNCT
ajst-32574	239	1	plos	plos	PROPN
ajst-32574	239	2	medicine	medicine	NOUN
ajst-32574	239	3	18	18	NUM
ajst-32574	239	4	,	,	PUNCT
ajst-32574	239	5	no	no	INTJ
ajst-32574	239	6	.	.	NOUN
ajst-32574	239	7	2	2	NUM
ajst-32574	239	8	(	(	PUNCT
ajst-32574	239	9	2021	2021	NUM
ajst-32574	239	10	):	):	PUNCT
ajst-32574	239	11	e1003536	e1003536	NOUN
ajst-32574	239	12	.	.	PUNCT
ajst-32574	240	1	https://	https://	PROPN
ajst-32574	240	2	doi	doi	PROPN
ajst-32574	240	3	.	.	PUNCT
ajst-32574	241	1	org/	org/	NOUN
ajst-32574	241	2	10.1371	10.1371	NUM
ajst-32574	241	3	/	/	SYM
ajst-32574	241	4	journal.pmed.1003536	journal.pmed.1003536	PROPN
ajst-32574	241	5	.	.	PUNCT
ajst-32574	242	1	[	[	X
ajst-32574	242	2	11	11	NUM
ajst-32574	242	3	]	]	X
ajst-32574	242	4	durá	durá	NOUN
ajst-32574	242	5	-	-	PUNCT
ajst-32574	242	6	travé	travé	NOUN
ajst-32574	242	7	,	,	PUNCT
ajst-32574	242	8	teodoro	teodoro	NOUN
ajst-32574	242	9	,	,	PUNCT
ajst-32574	242	10	and	and	CCONJ
ajst-32574	242	11	fidel	fidel	PROPN
ajst-32574	242	12	gallinas	gallina	NOUN
ajst-32574	242	13	-	-	PUNCT
ajst-32574	242	14	victoriano	victoriano	NOUN
ajst-32574	242	15	.	.	PUNCT
ajst-32574	243	1	“	"	PUNCT
ajst-32574	243	2	type	type	NOUN
ajst-32574	243	3	1	1	NUM
ajst-32574	243	4	diabetes	diabetes	NOUN
ajst-32574	243	5	mellitus	mellitus	NOUN
ajst-32574	243	6	and	and	CCONJ
ajst-32574	243	7	vitamin	vitamin	PROPN
ajst-32574	243	8	d.	d.	PROPN
ajst-32574	243	9	”	"	PUNCT
ajst-32574	243	10	international	international	ADJ
ajst-32574	243	11	journal	journal	NOUN
ajst-32574	243	12	of	of	ADP
ajst-32574	243	13	molecular	molecular	ADJ
ajst-32574	243	14	sciences	science	NOUN
ajst-32574	243	15	26	26	NUM
ajst-32574	243	16	,	,	PUNCT
ajst-32574	243	17	no	no	INTJ
ajst-32574	243	18	.	.	NOUN
ajst-32574	243	19	10	10	NUM
ajst-32574	243	20	(	(	PUNCT
ajst-32574	243	21	2025	2025	NUM
ajst-32574	243	22	):	):	PUNCT
ajst-32574	243	23	4593	4593	NUM
ajst-32574	243	24	.	.	PUNCT
ajst-32574	244	1	https://doi.org/	https://doi.org/	PROPN
ajst-32574	244	2	10.3390/	10.3390/	NUM
ajst-32574	244	3	ijms	ijm	VERB
ajst-32574	244	4	26104593	26104593	NUM
ajst-32574	244	5	.	.	PUNCT
ajst-32574	245	1	[	[	X
ajst-32574	245	2	12	12	NUM
ajst-32574	245	3	]	]	PUNCT
ajst-32574	245	4	he	he	PRON
ajst-32574	245	5	,	,	PUNCT
ajst-32574	245	6	lian	lian	ADJ
ajst-32574	245	7	-	-	PUNCT
ajst-32574	245	8	ping	ping	NOUN
ajst-32574	245	9	,	,	PUNCT
ajst-32574	245	10	yu	yu	PROPN
ajst-32574	245	11	-	-	PROPN
ajst-32574	245	12	xin	xin	PROPN
ajst-32574	245	13	song	song	PROPN
ajst-32574	245	14	,	,	PUNCT
ajst-32574	245	15	ting	ting	PROPN
ajst-32574	245	16	zhu	zhu	PROPN
ajst-32574	245	17	,	,	PUNCT
ajst-32574	245	18	wei	wei	PROPN
ajst-32574	245	19	gu	gu	PROPN
ajst-32574	245	20	,	,	PUNCT
ajst-32574	245	21	and	and	CCONJ
ajst-32574	245	22	chang	chang	PROPN
ajst-32574	245	23	-	-	PUNCT
ajst-32574	245	24	wei	wei	PROPN
ajst-32574	245	25	liu	liu	PROPN
ajst-32574	245	26	.	.	PUNCT
ajst-32574	246	1	“	"	PUNCT
ajst-32574	246	2	progress	progress	NOUN
ajst-32574	246	3	in	in	ADP
ajst-32574	246	4	the	the	DET
ajst-32574	246	5	relationship	relationship	NOUN
ajst-32574	246	6	between	between	ADP
ajst-32574	246	7	vitamin	vitamin	NOUN
ajst-32574	246	8	d	d	NOUN
ajst-32574	246	9	deficiency	deficiency	NOUN
ajst-32574	246	10	and	and	CCONJ
ajst-32574	246	11	the	the	DET
ajst-32574	246	12	incidence	incidence	NOUN
ajst-32574	246	13	of	of	ADP
ajst-32574	246	14	type	type	NOUN
ajst-32574	246	15	1	1	NUM
ajst-32574	246	16	diabetes	diabetes	NOUN
ajst-32574	246	17	mellitus	mellitus	NOUN
ajst-32574	246	18	in	in	ADP
ajst-32574	246	19	children	child	NOUN
ajst-32574	246	20	.	.	PUNCT
ajst-32574	246	21	”	"	PUNCT
ajst-32574	247	1	journal	journal	NOUN
ajst-32574	247	2	of	of	ADP
ajst-32574	247	3	diabetes	diabetes	NOUN
ajst-32574	247	4	research	research	VERB
ajst-32574	247	5	2022	2022	NUM
ajst-32574	247	6	(	(	PUNCT
ajst-32574	247	7	2022	2022	NUM
ajst-32574	247	8	):	):	PUNCT
ajst-32574	247	9	5953562	5953562	NUM
ajst-32574	247	10	.	.	PUNCT
ajst-32574	248	1	https://doi.org/10.1155/2022/5953562	https://doi.org/10.1155/2022/5953562	ADJ
ajst-32574	248	2	.	.	PUNCT
ajst-32574	249	1	[	[	X
ajst-32574	249	2	13	13	NUM
ajst-32574	249	3	]	]	SYM
ajst-32574	249	4	mazur	mazur	PROPN
ajst-32574	249	5	,	,	PUNCT
ajst-32574	249	6	artur	artur	PROPN
ajst-32574	249	7	,	,	PUNCT
ajst-32574	249	8	paulina	paulina	PROPN
ajst-32574	249	9	frączek	frączek	PROPN
ajst-32574	249	10	,	,	PUNCT
ajst-32574	249	11	and	and	CCONJ
ajst-32574	249	12	jacek	jacek	PROPN
ajst-32574	249	13	tabarkiewicz	tabarkiewicz	PROPN
ajst-32574	249	14	.	.	PUNCT
ajst-32574	250	1	“	"	PUNCT
ajst-32574	250	2	vitamin	vitamin	NOUN
ajst-32574	250	3	d	d	NOUN
ajst-32574	250	4	as	as	ADP
ajst-32574	250	5	a	a	DET
ajst-32574	250	6	nutri	nutri	ADJ
ajst-32574	250	7	-	-	ADJ
ajst-32574	250	8	epigenetic	epigenetic	ADJ
ajst-32574	250	9	factor	factor	NOUN
ajst-32574	250	10	in	in	ADP
ajst-32574	250	11	autoimmunity	autoimmunity	NOUN
ajst-32574	250	12	—	—	PUNCT
ajst-32574	250	13	a	a	DET
ajst-32574	250	14	review	review	NOUN
ajst-32574	250	15	of	of	ADP
ajst-32574	250	16	current	current	ADJ
ajst-32574	250	17	research	research	NOUN
ajst-32574	250	18	and	and	CCONJ
ajst-32574	250	19	reports	report	NOUN
ajst-32574	250	20	on	on	ADP
ajst-32574	250	21	vitamin	vitamin	NOUN
ajst-32574	250	22	d	d	NOUN
ajst-32574	250	23	deficiency	deficiency	NOUN
ajst-32574	250	24	in	in	ADP
ajst-32574	250	25	autoimmune	autoimmune	ADJ
ajst-32574	250	26	diseases	disease	NOUN
ajst-32574	250	27	.	.	PUNCT
ajst-32574	250	28	”	"	PUNCT
ajst-32574	250	29	nutrients	nutrient	NOUN
ajst-32574	250	30	14	14	NUM
ajst-32574	250	31	,	,	PUNCT
ajst-32574	250	32	no	no	INTJ
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ajst-32574	250	34	20	20	NUM
ajst-32574	250	35	(	(	PUNCT
ajst-32574	250	36	2022	2022	NUM
ajst-32574	250	37	):	):	PUNCT
ajst-32574	250	38	4286	4286	NUM
ajst-32574	250	39	.	.	PUNCT
ajst-32574	251	1	https://doi.org/10.3390/nu14204286	https://doi.org/10.3390/nu14204286	ADJ
ajst-32574	251	2	.	.	PUNCT
ajst-32574	252	1	[	[	X
ajst-32574	252	2	14	14	NUM
ajst-32574	252	3	]	]	PUNCT
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ajst-32574	252	5	,	,	PUNCT
ajst-32574	252	6	cecília	cecília	PROPN
ajst-32574	252	7	,	,	PUNCT
ajst-32574	252	8	alexandra	alexandra	PROPN
ajst-32574	252	9	machado	machado	PROPN
ajst-32574	252	10	,	,	PUNCT
ajst-32574	252	11	bruno	bruno	PROPN
ajst-32574	252	12	sarmento	sarmento	PROPN
ajst-32574	252	13	,	,	PUNCT
ajst-32574	252	14	and	and	CCONJ
ajst-32574	252	15	francisco	francisco	PROPN
ajst-32574	252	16	miguel	miguel	PROPN
ajst-32574	252	17	gama	gama	PROPN
ajst-32574	252	18	.	.	PUNCT
ajst-32574	253	1	“	"	PUNCT
ajst-32574	253	2	the	the	DET
ajst-32574	253	3	roles	role	NOUN
ajst-32574	253	4	of	of	ADP
ajst-32574	253	5	vitamin	vitamin	NOUN
ajst-32574	253	6	d	d	NOUN
ajst-32574	253	7	and	and	CCONJ
ajst-32574	253	8	cathelicidin	cathelicidin	VERB
ajst-32574	253	9	in	in	ADP
ajst-32574	253	10	type	type	NOUN
ajst-32574	253	11	1	1	NUM
ajst-32574	253	12	diabetes	diabetes	NOUN
ajst-32574	253	13	susceptibility	susceptibility	NOUN
ajst-32574	253	14	.	.	PUNCT
ajst-32574	253	15	”	"	PUNCT
ajst-32574	254	1	endocrine	endocrine	ADJ
ajst-32574	254	2	connections	connection	NOUN
ajst-32574	254	3	10	10	NUM
ajst-32574	254	4	,	,	PUNCT
ajst-32574	254	5	no	no	INTJ
ajst-32574	254	6	.	.	NOUN
ajst-32574	254	7	1	1	NUM
ajst-32574	254	8	(	(	PUNCT
ajst-32574	254	9	2021	2021	NUM
ajst-32574	254	10	):	):	PUNCT
ajst-32574	254	11	r1–12	r1–12	VERB
ajst-32574	254	12	.	.	PUNCT
ajst-32574	255	1	https://doi.org/10.1530/ec-20-0484	https://doi.org/10.1530/ec-20-0484	X
ajst-32574	255	2	.	.	PUNCT
ajst-32574	256	1	[	[	X
ajst-32574	256	2	15	15	NUM
ajst-32574	256	3	]	]	X
ajst-32574	256	4	hyöty	hyöty	PROPN
ajst-32574	256	5	,	,	PUNCT
ajst-32574	256	6	heikki	heikki	PROPN
ajst-32574	256	7	,	,	PUNCT
ajst-32574	256	8	jutta	jutta	PROPN
ajst-32574	256	9	e.	e.	PROPN
ajst-32574	256	10	laiho	laiho	PROPN
ajst-32574	256	11	,	,	PUNCT
ajst-32574	256	12	and	and	CCONJ
ajst-32574	256	13	suvi	suvi	PROPN
ajst-32574	256	14	m.	m.	NOUN
ajst-32574	256	15	virtanen	virtanen	NOUN
ajst-32574	256	16	.	.	PUNCT
ajst-32574	257	1	“	"	PUNCT
ajst-32574	257	2	environmental	environmental	ADJ
ajst-32574	257	3	factors	factor	NOUN
ajst-32574	257	4	in	in	ADP
ajst-32574	257	5	type	type	NOUN
ajst-32574	257	6	1	1	NUM
ajst-32574	257	7	diabetes	diabetes	NOUN
ajst-32574	257	8	.	.	PUNCT
ajst-32574	257	9	”	"	PUNCT
ajst-32574	258	1	cold	cold	ADJ
ajst-32574	258	2	spring	spring	NOUN
ajst-32574	258	3	harbor	harbor	NOUN
ajst-32574	258	4	perspectives	perspective	NOUN
ajst-32574	258	5	in	in	ADP
ajst-32574	258	6	medicine	medicine	NOUN
ajst-32574	258	7	,	,	PUNCT
ajst-32574	258	8	november	november	PROPN
ajst-32574	258	9	25	25	NUM
ajst-32574	258	10	,	,	PUNCT
ajst-32574	258	11	2024	2024	NUM
ajst-32574	258	12	,	,	PUNCT
ajst-32574	258	13	a041590	a041590	NOUN
ajst-32574	258	14	.	.	NOUN
ajst-32574	258	15	https://doi.org/	https://doi.org/	PROPN
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ajst-32574	258	17	cshperspect	cshperspect	ADJ
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ajst-32574	259	1	a041590	a041590	VERB
ajst-32574	259	2	.	.	PUNCT
ajst-32574	260	1	[	[	X
ajst-32574	260	2	16	16	NUM
ajst-32574	260	3	]	]	SYM
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ajst-32574	260	10	,	,	PUNCT
ajst-32574	260	11	zhen	zhen	PROPN
ajst-32574	260	12	zhang	zhang	PROPN
ajst-32574	260	13	,	,	PUNCT
ajst-32574	260	14	xiaolin	xiaolin	PROPN
ajst-32574	260	15	dai	dai	PROPN
ajst-32574	260	16	,	,	PUNCT
ajst-32574	260	17	yili	yili	PROPN
ajst-32574	260	18	zhang	zhang	PROPN
ajst-32574	260	19	,	,	PUNCT
ajst-32574	260	20	and	and	CCONJ
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ajst-32574	260	23	.	.	PUNCT
ajst-32574	261	1	“	"	PUNCT
ajst-32574	261	2	association	association	NOUN
ajst-32574	261	3	between	between	ADP
ajst-32574	261	4	enterovirus	enterovirus	NOUN
ajst-32574	261	5	infection	infection	NOUN
ajst-32574	261	6	and	and	CCONJ
ajst-32574	261	7	clinical	clinical	ADJ
ajst-32574	261	8	type	type	NOUN
ajst-32574	261	9	1	1	NUM
ajst-32574	261	10	diabetes	diabetes	NOUN
ajst-32574	261	11	mellitus	mellitus	NOUN
ajst-32574	261	12	:	:	PUNCT
ajst-32574	261	13	systematic	systematic	ADJ
ajst-32574	261	14	review	review	NOUN
ajst-32574	261	15	and	and	CCONJ
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ajst-32574	261	17	-	-	PUNCT
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ajst-32574	261	19	of	of	ADP
ajst-32574	261	20	observational	observational	ADJ
ajst-32574	261	21	studies	study	NOUN
ajst-32574	261	22	.	.	PUNCT
ajst-32574	261	23	”	"	PUNCT
ajst-32574	262	1	epidemiology	epidemiology	NOUN
ajst-32574	262	2	and	and	CCONJ
ajst-32574	262	3	infection	infection	NOUN
ajst-32574	262	4	150	150	NUM
ajst-32574	262	5	(	(	PUNCT
ajst-32574	262	6	december	december	PROPN
ajst-32574	262	7	2021	2021	NUM
ajst-32574	262	8	):	):	PUNCT
ajst-32574	262	9	e23	e23	NOUN
ajst-32574	262	10	.	.	PUNCT
ajst-32574	263	1	https://doi	https://doi	PROPN
ajst-32574	263	2	.	.	PUNCT
ajst-32574	264	1	org/10	org/10	PROPN
ajst-32574	264	2	.	.	PUNCT
ajst-32574	265	1	1017/	1017/	NUM
ajst-32574	265	2	s0950268821002442	s0950268821002442	NOUN
ajst-32574	265	3	.	.	PUNCT
ajst-32574	266	1	[	[	X
ajst-32574	266	2	17	17	NUM
ajst-32574	266	3	]	]	X
ajst-32574	266	4	wang	wang	PROPN
ajst-32574	266	5	,	,	PUNCT
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ajst-32574	266	7	,	,	PUNCT
ajst-32574	266	8	fei	fei	PROPN
ajst-32574	266	9	ye	ye	PROPN
ajst-32574	266	10	,	,	PUNCT
ajst-32574	266	11	yong	yong	PROPN
ajst-32574	266	12	chen	chen	PROPN
ajst-32574	266	13	,	,	PUNCT
ajst-32574	266	14	et	et	PROPN
ajst-32574	266	15	al	al	PROPN
ajst-32574	266	16	.	.	PUNCT
ajst-32574	266	17	“	"	PUNCT
ajst-32574	266	18	association	association	NOUN
ajst-32574	266	19	between	between	ADP
ajst-32574	266	20	enterovirus	enterovirus	NOUN
ajst-32574	266	21	infection	infection	NOUN
ajst-32574	266	22	and	and	CCONJ
ajst-32574	266	23	type	type	NOUN
ajst-32574	266	24	1	1	NUM
ajst-32574	266	25	diabetes	diabetes	NOUN
ajst-32574	266	26	risk	risk	NOUN
ajst-32574	266	27	:	:	PUNCT
ajst-32574	266	28	a	a	DET
ajst-32574	266	29	meta	meta	ADJ
ajst-32574	266	30	-	-	PUNCT
ajst-32574	266	31	analysis	analysis	NOUN
ajst-32574	266	32	of	of	ADP
ajst-32574	266	33	38	38	NUM
ajst-32574	266	34	case	case	NOUN
ajst-32574	266	35	-	-	PUNCT
ajst-32574	266	36	control	control	NOUN
ajst-32574	266	37	studies	study	NOUN
ajst-32574	266	38	.	.	PUNCT
ajst-32574	266	39	”	"	PUNCT
ajst-32574	266	40	frontiers	frontier	NOUN
ajst-32574	266	41	in	in	ADP
ajst-32574	266	42	endocrinology	endocrinology	NOUN
ajst-32574	266	43	12	12	NUM
ajst-32574	266	44	(	(	PUNCT
ajst-32574	266	45	2021	2021	NUM
ajst-32574	266	46	):	):	PUNCT
ajst-32574	266	47	706964	706964	NUM
ajst-32574	266	48	.	.	PUNCT
ajst-32574	267	1	https://	https://	PROPN
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ajst-32574	267	3	.	.	PUNCT
ajst-32574	268	1	[	[	X
ajst-32574	268	2	18	18	NUM
ajst-32574	268	3	]	]	PUNCT
ajst-32574	268	4	alves	alves	PROPN
ajst-32574	268	5	abrantes	abrantes	PROPN
ajst-32574	268	6	,	,	PUNCT
ajst-32574	268	7	jayra	jayra	PROPN
ajst-32574	268	8	juliana	juliana	PROPN
ajst-32574	268	9	paiva	paiva	PROPN
ajst-32574	268	10	,	,	PUNCT
ajst-32574	268	11	jenner	jenner	PROPN
ajst-32574	268	12	chrystian	chrystian	PROPN
ajst-32574	268	13	veríssimo	veríssimo	PROPN
ajst-32574	268	14	de	de	PROPN
ajst-32574	268	15	azevedo	azevedo	PROPN
ajst-32574	268	16	,	,	PUNCT
ajst-32574	268	17	fernando	fernando	PROPN
ajst-32574	268	18	liberalino	liberalino	PROPN
ajst-32574	268	19	fernandes	fernandes	PROPN
ajst-32574	268	20	,	,	PUNCT
ajst-32574	268	21	et	et	PROPN
ajst-32574	268	22	al	al	PROPN
ajst-32574	268	23	.	.	PUNCT
ajst-32574	269	1	“	"	PUNCT
ajst-32574	269	2	viruses	virus	NOUN
ajst-32574	269	3	as	as	ADP
ajst-32574	269	4	a	a	DET
ajst-32574	269	5	potential	potential	ADJ
ajst-32574	269	6	environmental	environmental	ADJ
ajst-32574	269	7	trigger	trigger	NOUN
ajst-32574	269	8	of	of	ADP
ajst-32574	269	9	type	type	NOUN
ajst-32574	269	10	1	1	NUM
ajst-32574	269	11	diabetes	diabetes	NOUN
ajst-32574	269	12	mellitus	mellitus	NOUN
ajst-32574	269	13	(	(	PUNCT
ajst-32574	269	14	review	review	NOUN
ajst-32574	269	15	)	)	PUNCT
ajst-32574	269	16	.	.	PUNCT
ajst-32574	269	17	”	"	PUNCT
ajst-32574	270	1	biomedical	biomedical	ADJ
ajst-32574	270	2	reports	report	NOUN
ajst-32574	270	3	20	20	NUM
ajst-32574	270	4	,	,	PUNCT
ajst-32574	270	5	no	no	INTJ
ajst-32574	270	6	.	.	NOUN
ajst-32574	270	7	5	5	NUM
ajst-32574	270	8	(	(	PUNCT
ajst-32574	270	9	2024	2024	NUM
ajst-32574	270	10	):	):	PUNCT
ajst-32574	270	11	81	81	NUM
ajst-32574	270	12	.	.	PUNCT
ajst-32574	270	13	https://doi.org/10.3892/br.2024.1770	https://doi.org/10.3892/br.2024.1770	NOUN
ajst-32574	270	14	.	.	PUNCT
ajst-32574	271	1	[	[	X
ajst-32574	271	2	19	19	NUM
ajst-32574	271	3	]	]	X
ajst-32574	271	4	lloyd	lloyd	PROPN
ajst-32574	271	5	,	,	PUNCT
ajst-32574	271	6	richard	richard	PROPN
ajst-32574	271	7	e.	e.	PROPN
ajst-32574	271	8	,	,	PUNCT
ajst-32574	271	9	manasi	manasi	PROPN
ajst-32574	271	10	tamhankar	tamhankar	NOUN
ajst-32574	271	11	,	,	PUNCT
ajst-32574	271	12	and	and	CCONJ
ajst-32574	271	13	åke	åke	ADP
ajst-32574	271	14	lernmark	lernmark	NOUN
ajst-32574	271	15	.	.	PUNCT
ajst-32574	272	1	“	"	PUNCT
ajst-32574	272	2	enteroviruses	enterovirus	NOUN
ajst-32574	272	3	and	and	CCONJ
ajst-32574	272	4	type	type	NOUN
ajst-32574	272	5	1	1	NUM
ajst-32574	272	6	diabetes	diabetes	NOUN
ajst-32574	272	7	:	:	PUNCT
ajst-32574	272	8	multiple	multiple	ADJ
ajst-32574	272	9	mechanisms	mechanism	NOUN
ajst-32574	272	10	and	and	CCONJ
ajst-32574	272	11	factors	factor	NOUN
ajst-32574	272	12	?	?	PUNCT
ajst-32574	272	13	”	"	PUNCT
ajst-32574	272	14	annual	annual	ADJ
ajst-32574	272	15	review	review	NOUN
ajst-32574	272	16	of	of	ADP
ajst-32574	272	17	medicine	medicine	NOUN
ajst-32574	272	18	73	73	NUM
ajst-32574	272	19	(	(	PUNCT
ajst-32574	272	20	january	january	PROPN
ajst-32574	272	21	2022	2022	NUM
ajst-32574	272	22	):	):	PUNCT
ajst-32574	272	23	483–99	483–99	NUM
ajst-32574	272	24	.	.	PUNCT
ajst-32574	272	25	https://doi.org/	https://doi.org/	PROPN
ajst-32574	272	26	10	10	NUM
ajst-32574	272	27	.	.	PUNCT
ajst-32574	272	28	1146	1146	NUM
ajst-32574	272	29	/	/	SYM
ajst-32574	272	30	annurev	annurev	NOUN
ajst-32574	272	31	-	-	PUNCT
ajst-32574	272	32	med-042320	med-042320	NOUN
ajst-32574	272	33	-	-	PUNCT
ajst-32574	272	34	015952	015952	NUM
ajst-32574	272	35	.	.	PUNCT
ajst-32574	273	1	[	[	X
ajst-32574	273	2	20	20	NUM
ajst-32574	273	3	]	]	SYM
ajst-32574	273	4	yu	yu	PROPN
ajst-32574	273	5	,	,	PUNCT
ajst-32574	273	6	yueyang	yueyang	PROPN
ajst-32574	273	7	,	,	PUNCT
ajst-32574	273	8	mengyin	mengyin	PROPN
ajst-32574	273	9	li	li	PROPN
ajst-32574	273	10	,	,	PUNCT
ajst-32574	273	11	yuxuan	yuxuan	PROPN
ajst-32574	273	12	zhao	zhao	PROPN
ajst-32574	273	13	,	,	PUNCT
ajst-32574	273	14	et	et	PROPN
ajst-32574	273	15	al	al	PROPN
ajst-32574	273	16	.	.	PUNCT
ajst-32574	273	17	“	"	PUNCT
ajst-32574	273	18	immune	immune	ADJ
ajst-32574	273	19	cell	cell	NOUN
ajst-32574	273	20	-	-	PUNCT
ajst-32574	273	21	derived	derive	VERB
ajst-32574	273	22	extracellular	extracellular	ADJ
ajst-32574	273	23	vesicular	vesicular	ADJ
ajst-32574	273	24	micrornas	microrna	NOUN
ajst-32574	273	25	induce	induce	VERB
ajst-32574	273	26	pancreatic	pancreatic	ADJ
ajst-32574	273	27	beta	beta	NOUN
ajst-32574	273	28	cell	cell	NOUN
ajst-32574	273	29	apoptosis	apoptosis	NOUN
ajst-32574	273	30	.	.	PUNCT
ajst-32574	273	31	”	"	PUNCT
ajst-32574	273	32	heliyon	heliyon	NOUN
ajst-32574	273	33	8	8	NUM
ajst-32574	273	34	,	,	PUNCT
ajst-32574	273	35	no	no	INTJ
ajst-32574	273	36	.	.	NOUN
ajst-32574	273	37	12	12	NUM
ajst-32574	273	38	(	(	PUNCT
ajst-32574	273	39	2022	2022	NUM
ajst-32574	273	40	):	):	PUNCT
ajst-32574	273	41	e11995	e11995	NOUN
ajst-32574	273	42	.	.	PROPN
ajst-32574	273	43	https://doi.org/	https://doi.org/	PROPN
ajst-32574	273	44	10.1016/	10.1016/	NUM
ajst-32574	273	45	j.	j.	PROPN
ajst-32574	273	46	heliyon	heliyon	PROPN
ajst-32574	273	47	.	.	PUNCT
ajst-32574	274	1	2022	2022	NUM
ajst-32574	274	2	.	.	PUNCT
ajst-32574	275	1	e11995	e11995	VERB
ajst-32574	275	2	.	.	PUNCT
ajst-32574	276	1	[	[	X
ajst-32574	276	2	21	21	NUM
ajst-32574	276	3	]	]	X
ajst-32574	276	4	rodriguez	rodriguez	NOUN
ajst-32574	276	5	-	-	PUNCT
ajst-32574	276	6	calvo	calvo	PROPN
ajst-32574	276	7	,	,	PUNCT
ajst-32574	276	8	teresa	teresa	PROPN
ajst-32574	276	9	,	,	PUNCT
ajst-32574	276	10	jutta	jutta	PROPN
ajst-32574	276	11	e.	e.	PROPN
ajst-32574	276	12	laiho	laiho	PROPN
ajst-32574	276	13	,	,	PUNCT
ajst-32574	276	14	maarit	maarit	PROPN
ajst-32574	276	15	oikarinen	oikarinen	PROPN
ajst-32574	276	16	,	,	PUNCT
ajst-32574	276	17	et	et	PROPN
ajst-32574	276	18	al	al	PROPN
ajst-32574	276	19	.	.	PUNCT
ajst-32574	276	20	“	"	PUNCT
ajst-32574	276	21	enterovirus	enterovirus	NOUN
ajst-32574	276	22	vp1	vp1	NOUN
ajst-32574	276	23	protein	protein	NOUN
ajst-32574	276	24	and	and	CCONJ
ajst-32574	276	25	hla	hla	PROPN
ajst-32574	276	26	class	class	NOUN
ajst-32574	276	27	i	i	PROPN
ajst-32574	276	28	hyperexpression	hyperexpression	NOUN
ajst-32574	276	29	in	in	ADP
ajst-32574	276	30	pancreatic	pancreatic	ADJ
ajst-32574	276	31	islet	islet	NOUN
ajst-32574	276	32	cells	cell	NOUN
ajst-32574	276	33	of	of	ADP
ajst-32574	276	34	organ	organ	NOUN
ajst-32574	276	35	donors	donor	NOUN
ajst-32574	276	36	with	with	ADP
ajst-32574	276	37	type	type	NOUN
ajst-32574	276	38	1	1	NUM
ajst-32574	276	39	diabetes	diabetes	NOUN
ajst-32574	276	40	.	.	PUNCT
ajst-32574	276	41	”	"	PUNCT
ajst-32574	277	1	diabetologia	diabetologia	NOUN
ajst-32574	277	2	68	68	NUM
ajst-32574	277	3	,	,	PUNCT
ajst-32574	277	4	no	no	INTJ
ajst-32574	277	5	.	.	NOUN
ajst-32574	277	6	6	6	NUM
ajst-32574	277	7	(	(	PUNCT
ajst-32574	277	8	2025	2025	NUM
ajst-32574	277	9	):	):	PUNCT
ajst-32574	277	10	1197–210	1197–210	NOUN
ajst-32574	277	11	.	.	PUNCT
ajst-32574	278	1	https://doi.org/10.1007/s00125-025-06384-9	https://doi.org/10.1007/s00125-025-06384-9	NUM
ajst-32574	278	2	.	.	PUNCT
ajst-32574	279	1	213	213	NUM
ajst-32574	279	2	[	[	SYM
ajst-32574	279	3	22	22	NUM
ajst-32574	279	4	]	]	X
ajst-32574	279	5	oikarinen	oikarinen	NOUN
ajst-32574	279	6	,	,	PUNCT
ajst-32574	279	7	sami	sami	PROPN
ajst-32574	279	8	,	,	PUNCT
ajst-32574	279	9	lars	lars	PROPN
ajst-32574	279	10	krogvold	krogvold	PROPN
ajst-32574	279	11	,	,	PUNCT
ajst-32574	279	12	bjørn	bjørn	PROPN
ajst-32574	279	13	edwin	edwin	PROPN
ajst-32574	279	14	,	,	PUNCT
ajst-32574	279	15	et	et	PROPN
ajst-32574	279	16	al	al	PROPN
ajst-32574	279	17	.	.	PUNCT
ajst-32574	280	1	“	"	PUNCT
ajst-32574	280	2	characterisation	characterisation	NOUN
ajst-32574	280	3	of	of	ADP
ajst-32574	280	4	enterovirus	enterovirus	NOUN
ajst-32574	280	5	rna	rna	NOUN
ajst-32574	280	6	detected	detect	VERB
ajst-32574	280	7	in	in	ADP
ajst-32574	280	8	the	the	DET
ajst-32574	280	9	pancreas	pancrea	NOUN
ajst-32574	280	10	and	and	CCONJ
ajst-32574	280	11	other	other	ADJ
ajst-32574	280	12	specimens	specimen	NOUN
ajst-32574	280	13	of	of	ADP
ajst-32574	280	14	live	live	ADJ
ajst-32574	280	15	patients	patient	NOUN
ajst-32574	280	16	with	with	ADP
ajst-32574	280	17	newly	newly	ADV
ajst-32574	280	18	diagnosed	diagnose	VERB
ajst-32574	280	19	type	type	NOUN
ajst-32574	280	20	1	1	NUM
ajst-32574	280	21	diabetes	diabetes	NOUN
ajst-32574	280	22	in	in	ADP
ajst-32574	280	23	the	the	DET
ajst-32574	280	24	divid	divid	PROPN
ajst-32574	280	25	study	study	NOUN
ajst-32574	280	26	.	.	PUNCT
ajst-32574	280	27	”	"	PUNCT
ajst-32574	281	1	diabetologia	diabetologia	NOUN
ajst-32574	281	2	64	64	NUM
ajst-32574	281	3	,	,	PUNCT
ajst-32574	281	4	no	no	INTJ
ajst-32574	281	5	.	.	NOUN
ajst-32574	281	6	11	11	NUM
ajst-32574	281	7	(	(	PUNCT
ajst-32574	281	8	2021	2021	NUM
ajst-32574	281	9	):	):	PUNCT
ajst-32574	281	10	2491–501	2491–501	NOUN
ajst-32574	281	11	.	.	PUNCT
ajst-32574	282	1	https://doi.org/10.1007/s00125-021-05525-0	https://doi.org/10.1007/s00125-021-05525-0	NUM
ajst-32574	282	2	.	.	PUNCT
ajst-32574	283	1	[	[	X
ajst-32574	283	2	23	23	NUM
ajst-32574	283	3	]	]	X
ajst-32574	283	4	laiho	laiho	PROPN
ajst-32574	283	5	,	,	PUNCT
ajst-32574	283	6	jutta	jutta	PROPN
ajst-32574	283	7	e.	e.	PROPN
ajst-32574	283	8	,	,	PUNCT
ajst-32574	283	9	sami	sami	PROPN
ajst-32574	283	10	oikarinen	oikarinen	PROPN
ajst-32574	283	11	,	,	PUNCT
ajst-32574	283	12	sofia	sofia	PROPN
ajst-32574	283	13	morfopoulou	morfopoulou	PROPN
ajst-32574	283	14	,	,	PUNCT
ajst-32574	283	15	et	et	PROPN
ajst-32574	283	16	al	al	PROPN
ajst-32574	283	17	.	.	PUNCT
ajst-32574	284	1	“	"	PUNCT
ajst-32574	284	2	detection	detection	NOUN
ajst-32574	284	3	of	of	ADP
ajst-32574	284	4	enterovirus	enterovirus	NOUN
ajst-32574	284	5	rna	rna	NOUN
ajst-32574	284	6	in	in	ADP
ajst-32574	284	7	pancreas	pancrea	NOUN
ajst-32574	284	8	and	and	CCONJ
ajst-32574	284	9	lymphoid	lymphoid	ADJ
ajst-32574	284	10	tissues	tissue	NOUN
ajst-32574	284	11	of	of	ADP
ajst-32574	284	12	organ	organ	NOUN
ajst-32574	284	13	donors	donor	NOUN
ajst-32574	284	14	with	with	ADP
ajst-32574	284	15	type	type	NOUN
ajst-32574	284	16	1	1	NUM
ajst-32574	284	17	diabetes	diabetes	NOUN
ajst-32574	284	18	.	.	PUNCT
ajst-32574	284	19	”	"	PUNCT
ajst-32574	285	1	diabetologia	diabetologia	NOUN
ajst-32574	285	2	68	68	NUM
ajst-32574	285	3	,	,	PUNCT
ajst-32574	285	4	no	no	INTJ
ajst-32574	285	5	.	.	NOUN
ajst-32574	285	6	6	6	NUM
ajst-32574	285	7	(	(	PUNCT
ajst-32574	285	8	2025	2025	NUM
ajst-32574	285	9	):	):	PUNCT
ajst-32574	285	10	1211–25	1211–25	NUM
ajst-32574	285	11	.	.	PUNCT
ajst-32574	286	1	https://doi.org/10.1007/s00125-025-06359-w	https://doi.org/10.1007/s00125-025-06359-w	NOUN
ajst-32574	286	2	.	.	PUNCT
ajst-32574	287	1	[	[	X
ajst-32574	287	2	24	24	NUM
ajst-32574	287	3	]	]	X
ajst-32574	287	4	kohil	kohil	PROPN
ajst-32574	287	5	,	,	PUNCT
ajst-32574	287	6	amira	amira	PROPN
ajst-32574	287	7	,	,	PUNCT
ajst-32574	287	8	maha	maha	PROPN
ajst-32574	287	9	al	al	PROPN
ajst-32574	287	10	-	-	PROPN
ajst-32574	287	11	asmakh	asmakh	PROPN
ajst-32574	287	12	,	,	PUNCT
ajst-32574	287	13	mashael	mashael	PROPN
ajst-32574	287	14	al	al	PROPN
ajst-32574	287	15	-	-	PUNCT
ajst-32574	287	16	shafai	shafai	PROPN
ajst-32574	287	17	,	,	PUNCT
ajst-32574	287	18	and	and	CCONJ
ajst-32574	287	19	annalisa	annalisa	PROPN
ajst-32574	287	20	terranegra	terranegra	PROPN
ajst-32574	287	21	.	.	PUNCT
ajst-32574	288	1	“	"	PUNCT
ajst-32574	288	2	the	the	DET
ajst-32574	288	3	interplay	interplay	NOUN
ajst-32574	288	4	between	between	ADP
ajst-32574	288	5	diet	diet	NOUN
ajst-32574	288	6	and	and	CCONJ
ajst-32574	288	7	the	the	DET
ajst-32574	288	8	epigenome	epigenome	NOUN
ajst-32574	288	9	in	in	ADP
ajst-32574	288	10	the	the	DET
ajst-32574	288	11	pathogenesis	pathogenesis	NOUN
ajst-32574	288	12	of	of	ADP
ajst-32574	288	13	type-1	type-1	PROPN
ajst-32574	288	14	diabetes	diabete	NOUN
ajst-32574	288	15	.	.	PUNCT
ajst-32574	288	16	”	"	PUNCT
ajst-32574	288	17	frontiers	frontier	NOUN
ajst-32574	288	18	in	in	ADP
ajst-32574	288	19	nutrition	nutrition	NOUN
ajst-32574	288	20	7	7	NUM
ajst-32574	288	21	(	(	PUNCT
ajst-32574	288	22	2020	2020	NUM
ajst-32574	288	23	):	):	PUNCT
ajst-32574	288	24	612115	612115	NUM
ajst-32574	288	25	.	.	PUNCT
ajst-32574	289	1	https://doi.org/10.3389/fnut.2020.612115	https://doi.org/10.3389/fnut.2020.612115	PROPN
ajst-32574	289	2	.	.	PUNCT
ajst-32574	290	1	[	[	X
ajst-32574	290	2	25	25	NUM
ajst-32574	290	3	]	]	X
ajst-32574	290	4	mittal	mittal	ADJ
ajst-32574	290	5	,	,	PUNCT
ajst-32574	290	6	rahul	rahul	PROPN
ajst-32574	290	7	,	,	PUNCT
ajst-32574	290	8	nathanael	nathanael	PROPN
ajst-32574	290	9	camick	camick	PROPN
ajst-32574	290	10	,	,	PUNCT
ajst-32574	290	11	joana	joana	PROPN
ajst-32574	290	12	r.	r.	PROPN
ajst-32574	290	13	n.	n.	PROPN
ajst-32574	290	14	lemos	lemos	PROPN
ajst-32574	290	15	,	,	PUNCT
ajst-32574	290	16	and	and	CCONJ
ajst-32574	290	17	khemraj	khemraj	ADJ
ajst-32574	290	18	hirani	hirani	NOUN
ajst-32574	290	19	.	.	PUNCT
ajst-32574	291	1	“	"	PUNCT
ajst-32574	291	2	gene	gene	NOUN
ajst-32574	291	3	-	-	PUNCT
ajst-32574	291	4	environment	environment	NOUN
ajst-32574	291	5	interaction	interaction	NOUN
ajst-32574	291	6	in	in	ADP
ajst-32574	291	7	the	the	DET
ajst-32574	291	8	pathophysiology	pathophysiology	NOUN
ajst-32574	291	9	of	of	ADP
ajst-32574	291	10	type	type	NOUN
ajst-32574	291	11	1	1	NUM
ajst-32574	291	12	diabetes	diabetes	NOUN
ajst-32574	291	13	.	.	PUNCT
ajst-32574	291	14	”	"	PUNCT
ajst-32574	291	15	frontiers	frontier	NOUN
ajst-32574	291	16	in	in	ADP
ajst-32574	291	17	endocrinology	endocrinology	NOUN
ajst-32574	291	18	15	15	NUM
ajst-32574	291	19	(	(	PUNCT
ajst-32574	291	20	january	january	PROPN
ajst-32574	291	21	2024	2024	NUM
ajst-32574	291	22	):	):	PUNCT
ajst-32574	291	23	1335435	1335435	NUM
ajst-32574	291	24	.	.	PUNCT
ajst-32574	292	1	https://doi.org/10.3389/fendo.2024.1335435	https://doi.org/10.3389/fendo.2024.1335435	PROPN
ajst-32574	292	2	.	.	PUNCT
ajst-32574	293	1	[	[	X
ajst-32574	293	2	26	26	NUM
ajst-32574	293	3	]	]	X
ajst-32574	293	4	xie	xie	PROPN
ajst-32574	293	5	,	,	PUNCT
ajst-32574	293	6	zhiguo	zhiguo	PROPN
ajst-32574	293	7	,	,	PUNCT
ajst-32574	293	8	christopher	christopher	PROPN
ajst-32574	293	9	chang	chang	PROPN
ajst-32574	293	10	,	,	PUNCT
ajst-32574	293	11	gan	gan	PROPN
ajst-32574	293	12	huang	huang	PROPN
ajst-32574	293	13	,	,	PUNCT
ajst-32574	293	14	and	and	CCONJ
ajst-32574	293	15	zhiguang	zhiguang	PROPN
ajst-32574	293	16	zhou	zhou	PROPN
ajst-32574	293	17	.	.	PUNCT
ajst-32574	294	1	“	"	PUNCT
ajst-32574	294	2	the	the	DET
ajst-32574	294	3	role	role	NOUN
ajst-32574	294	4	of	of	ADP
ajst-32574	294	5	epigenetics	epigenetic	NOUN
ajst-32574	294	6	in	in	ADP
ajst-32574	294	7	type	type	NOUN
ajst-32574	294	8	1	1	NUM
ajst-32574	294	9	diabetes	diabetes	NOUN
ajst-32574	294	10	.	.	PUNCT
ajst-32574	294	11	”	"	PUNCT
ajst-32574	295	1	advances	advance	NOUN
ajst-32574	295	2	in	in	ADP
ajst-32574	295	3	experimental	experimental	ADJ
ajst-32574	295	4	medicine	medicine	NOUN
ajst-32574	295	5	and	and	CCONJ
ajst-32574	295	6	biology	biology	NOUN
ajst-32574	295	7	1253	1253	NUM
ajst-32574	295	8	(	(	PUNCT
ajst-32574	295	9	2020	2020	NUM
ajst-32574	295	10	):	):	PUNCT
ajst-32574	295	11	223–57	223–57	NUM
ajst-32574	295	12	.	.	PUNCT
ajst-32574	296	1	https://doi.org/10	https://doi.org/10	PROPN
ajst-32574	296	2	.	.	PUNCT
ajst-32574	297	1	1007/	1007/	NUM
ajst-32574	297	2	978	978	NUM
ajst-32574	297	3	-	-	SYM
ajst-32574	297	4	981	981	NUM
ajst-32574	297	5	-	-	PUNCT
ajst-32574	297	6	15	15	NUM
ajst-32574	297	7	-	-	PUNCT
ajst-32574	297	8	3449	3449	NUM
ajst-32574	297	9	-	-	PUNCT
ajst-32574	297	10	2_9	2_9	NUM
ajst-32574	297	11	.	.	PUNCT
ajst-32574	298	1	[	[	X
ajst-32574	298	2	27	27	NUM
ajst-32574	298	3	]	]	X
ajst-32574	298	4	akil	akil	NOUN
ajst-32574	298	5	,	,	PUNCT
ajst-32574	298	6	ammira	ammira	PROPN
ajst-32574	298	7	-	-	PUNCT
ajst-32574	298	8	sarah	sarah	PROPN
ajst-32574	298	9	al	al	PROPN
ajst-32574	298	10	-	-	PUNCT
ajst-32574	298	11	shabeeb	shabeeb	PROPN
ajst-32574	298	12	,	,	PUNCT
ajst-32574	298	13	laila	laila	PROPN
ajst-32574	298	14	f.	f.	PROPN
ajst-32574	298	15	jerman	jerman	PROPN
ajst-32574	298	16	,	,	PUNCT
ajst-32574	298	17	esraa	esraa	PROPN
ajst-32574	298	18	yassin	yassin	PROPN
ajst-32574	298	19	,	,	PUNCT
ajst-32574	298	20	sujitha	sujitha	PROPN
ajst-32574	298	21	s.	s.	PROPN
ajst-32574	298	22	padmajeya	padmajeya	PROPN
ajst-32574	298	23	,	,	PUNCT
ajst-32574	298	24	alya	alya	PROPN
ajst-32574	298	25	al	al	PROPN
ajst-32574	298	26	-	-	PUNCT
ajst-32574	298	27	kurbi	kurbi	PROPN
ajst-32574	298	28	,	,	PUNCT
ajst-32574	298	29	and	and	CCONJ
ajst-32574	298	30	khalid	khalid	PROPN
ajst-32574	298	31	a.	a.	PROPN
ajst-32574	298	32	fakhro	fakhro	PROPN
ajst-32574	298	33	.	.	PUNCT
ajst-32574	299	1	“	"	PUNCT
ajst-32574	299	2	reading	read	VERB
ajst-32574	299	3	between	between	ADP
ajst-32574	299	4	the	the	DET
ajst-32574	299	5	(	(	PUNCT
ajst-32574	299	6	genetic	genetic	ADJ
ajst-32574	299	7	)	)	PUNCT
ajst-32574	299	8	lines	line	NOUN
ajst-32574	299	9	:	:	PUNCT
ajst-32574	299	10	how	how	SCONJ
ajst-32574	299	11	epigenetics	epigenetic	NOUN
ajst-32574	299	12	is	be	AUX
ajst-32574	299	13	unlocking	unlock	VERB
ajst-32574	299	14	novel	novel	ADJ
ajst-32574	299	15	therapies	therapy	NOUN
ajst-32574	299	16	for	for	ADP
ajst-32574	299	17	type	type	NOUN
ajst-32574	299	18	1	1	NUM
ajst-32574	299	19	diabetes	diabetes	NOUN
ajst-32574	299	20	.	.	PUNCT
ajst-32574	299	21	”	"	PUNCT
ajst-32574	299	22	cells	cell	NOUN
ajst-32574	299	23	9	9	NUM
ajst-32574	299	24	,	,	PUNCT
ajst-32574	299	25	no	no	INTJ
ajst-32574	299	26	.	.	NOUN
ajst-32574	299	27	11	11	NUM
ajst-32574	299	28	(	(	PUNCT
ajst-32574	299	29	2020	2020	NUM
ajst-32574	299	30	):	):	PUNCT
ajst-32574	299	31	2403	2403	NUM
ajst-32574	299	32	.	.	PUNCT
ajst-32574	300	1	https://doi.org/10.3390/cells9112403	https://doi.org/10.3390/cells9112403	NOUN
ajst-32574	300	2	.	.	PUNCT
ajst-32574	301	1	[	[	X
ajst-32574	301	2	28	28	NUM
ajst-32574	301	3	]	]	X
ajst-32574	301	4	čugalj	čugalj	PROPN
ajst-32574	301	5	kern	kern	PROPN
ajst-32574	301	6	,	,	PUNCT
ajst-32574	301	7	barbara	barbara	PROPN
ajst-32574	301	8	,	,	PUNCT
ajst-32574	301	9	jernej	jernej	PROPN
ajst-32574	301	10	kovač	kovač	PROPN
ajst-32574	301	11	,	,	PUNCT
ajst-32574	301	12	robert	robert	PROPN
ajst-32574	301	13	šket	šket	PROPN
ajst-32574	301	14	,	,	PUNCT
ajst-32574	301	15	et	et	PROPN
ajst-32574	301	16	al	al	PROPN
ajst-32574	301	17	.	.	PUNCT
ajst-32574	302	1	“	"	PUNCT
ajst-32574	302	2	exploring	explore	VERB
ajst-32574	302	3	early	early	ADJ
ajst-32574	302	4	dna	dna	PROPN
ajst-32574	302	5	methylation	methylation	NOUN
ajst-32574	302	6	alterations	alteration	NOUN
ajst-32574	302	7	in	in	ADP
ajst-32574	302	8	type	type	NOUN
ajst-32574	302	9	1	1	NUM
ajst-32574	302	10	diabetes	diabete	NOUN
ajst-32574	302	11	:	:	PUNCT
ajst-32574	302	12	implications	implication	NOUN
ajst-32574	302	13	of	of	ADP
ajst-32574	302	14	glycemic	glycemic	ADJ
ajst-32574	302	15	control	control	NOUN
ajst-32574	302	16	.	.	PUNCT
ajst-32574	302	17	”	"	PUNCT
ajst-32574	302	18	frontiers	frontier	NOUN
ajst-32574	302	19	in	in	ADP
ajst-32574	302	20	endocrinology	endocrinology	NOUN
ajst-32574	302	21	15	15	NUM
ajst-32574	302	22	(	(	PUNCT
ajst-32574	302	23	2024	2024	NUM
ajst-32574	302	24	):	):	PUNCT
ajst-32574	302	25	1416433	1416433	NUM
ajst-32574	302	26	.	.	PUNCT
ajst-32574	303	1	https://doi.org/10.3389/fendo.2024.1416433	https://doi.org/10.3389/fendo.2024.1416433	NOUN
ajst-32574	303	2	.	.	PUNCT
ajst-32574	304	1	[	[	X
ajst-32574	304	2	29	29	NUM
ajst-32574	304	3	]	]	X
ajst-32574	304	4	paul	paul	PROPN
ajst-32574	304	5	,	,	PUNCT
ajst-32574	304	6	dirk	dirk	PROPN
ajst-32574	304	7	s.	s.	PROPN
ajst-32574	304	8	,	,	PUNCT
ajst-32574	304	9	andrew	andrew	PROPN
ajst-32574	304	10	e.	e.	PROPN
ajst-32574	304	11	teschendorff	teschendorff	PROPN
ajst-32574	304	12	,	,	PUNCT
ajst-32574	304	13	mary	mary	PROPN
ajst-32574	304	14	a.	a.	PROPN
ajst-32574	304	15	n.	n.	PROPN
ajst-32574	304	16	dang	dang	PROPN
ajst-32574	304	17	,	,	PUNCT
ajst-32574	304	18	et	et	PROPN
ajst-32574	304	19	al	al	PROPN
ajst-32574	304	20	.	.	PUNCT
ajst-32574	304	21	“	"	PUNCT
ajst-32574	304	22	increased	increase	VERB
ajst-32574	304	23	dna	dna	PROPN
ajst-32574	304	24	methylation	methylation	NOUN
ajst-32574	304	25	variability	variability	NOUN
ajst-32574	304	26	in	in	ADP
ajst-32574	304	27	type	type	NOUN
ajst-32574	304	28	1	1	NUM
ajst-32574	304	29	diabetes	diabetes	NOUN
ajst-32574	304	30	across	across	ADP
ajst-32574	304	31	three	three	NUM
ajst-32574	304	32	immune	immune	ADJ
ajst-32574	304	33	effector	effector	NOUN
ajst-32574	304	34	cell	cell	NOUN
ajst-32574	304	35	types	type	NOUN
ajst-32574	304	36	.	.	PUNCT
ajst-32574	304	37	”	"	PUNCT
ajst-32574	305	1	nature	nature	NOUN
ajst-32574	305	2	communications	communication	NOUN
ajst-32574	305	3	7	7	NUM
ajst-32574	305	4	(	(	PUNCT
ajst-32574	305	5	november	november	PROPN
ajst-32574	305	6	2016	2016	NUM
ajst-32574	305	7	):	):	PUNCT
ajst-32574	305	8	13555	13555	NUM
ajst-32574	305	9	.	.	PUNCT
ajst-32574	306	1	https://doi.org/10.1038/ncomms13555	https://doi.org/10.1038/ncomms13555	NOUN
ajst-32574	306	2	.	.	PUNCT
ajst-32574	307	1	[	[	X
ajst-32574	307	2	30	30	NUM
ajst-32574	307	3	]	]	X
ajst-32574	307	4	stefan	stefan	PROPN
ajst-32574	307	5	,	,	PUNCT
ajst-32574	307	6	mihaela	mihaela	PROPN
ajst-32574	307	7	,	,	PUNCT
ajst-32574	307	8	weijia	weijia	X
ajst-32574	307	9	zhang	zhang	PROPN
ajst-32574	307	10	,	,	PUNCT
ajst-32574	307	11	erlinda	erlinda	PROPN
ajst-32574	307	12	concepcion	concepcion	PROPN
ajst-32574	307	13	,	,	PUNCT
ajst-32574	307	14	zhengzi	zhengzi	NOUN
ajst-32574	307	15	yi	yi	NOUN
ajst-32574	307	16	,	,	PUNCT
ajst-32574	307	17	and	and	CCONJ
ajst-32574	307	18	yaron	yaron	PROPN
ajst-32574	307	19	tomer	tomer	PROPN
ajst-32574	307	20	.	.	PUNCT
ajst-32574	308	1	“	"	PUNCT
ajst-32574	308	2	dna	dna	PROPN
ajst-32574	308	3	methylation	methylation	NOUN
ajst-32574	308	4	profiles	profile	NOUN
ajst-32574	308	5	in	in	ADP
ajst-32574	308	6	type	type	NOUN
ajst-32574	308	7	1	1	NUM
ajst-32574	308	8	diabetes	diabetes	NOUN
ajst-32574	308	9	twins	twin	NOUN
ajst-32574	308	10	point	point	VERB
ajst-32574	308	11	to	to	ADP
ajst-32574	308	12	strong	strong	ADJ
ajst-32574	308	13	epigenetic	epigenetic	ADJ
ajst-32574	308	14	effects	effect	NOUN
ajst-32574	308	15	on	on	ADP
ajst-32574	308	16	etiology	etiology	NOUN
ajst-32574	308	17	.	.	PUNCT
ajst-32574	308	18	”	"	PUNCT
ajst-32574	309	1	journal	journal	NOUN
ajst-32574	309	2	of	of	ADP
ajst-32574	309	3	autoimmunity	autoimmunity	NOUN
ajst-32574	309	4	50	50	NUM
ajst-32574	309	5	(	(	PUNCT
ajst-32574	309	6	may	may	PROPN
ajst-32574	309	7	2014	2014	NUM
ajst-32574	309	8	):	):	PUNCT
ajst-32574	309	9	33–37	33–37	NUM
ajst-32574	309	10	.	.	PUNCT
ajst-32574	310	1	https://doi.org/10.1016/j.jaut.2013.10.001	https://doi.org/10.1016/j.jaut.2013.10.001	PROPN
ajst-32574	310	2	.	.	PUNCT
ajst-32574	311	1	[	[	X
ajst-32574	311	2	31	31	NUM
ajst-32574	311	3	]	]	X
ajst-32574	311	4	johnson	johnson	PROPN
ajst-32574	311	5	,	,	PUNCT
ajst-32574	311	6	randi	randi	PROPN
ajst-32574	311	7	k.	k.	PROPN
ajst-32574	311	8	,	,	PUNCT
ajst-32574	311	9	lauren	lauren	PROPN
ajst-32574	311	10	a.	a.	PROPN
ajst-32574	311	11	vanderlinden	vanderlinden	PROPN
ajst-32574	311	12	,	,	PUNCT
ajst-32574	311	13	fran	fran	PROPN
ajst-32574	311	14	dong	dong	PROPN
ajst-32574	311	15	,	,	PUNCT
ajst-32574	311	16	et	et	PROPN
ajst-32574	311	17	al	al	PROPN
ajst-32574	311	18	.	.	PUNCT
ajst-32574	312	1	“	"	PUNCT
ajst-32574	312	2	longitudinal	longitudinal	ADJ
ajst-32574	312	3	dna	dna	PROPN
ajst-32574	312	4	methylation	methylation	NOUN
ajst-32574	312	5	differences	difference	NOUN
ajst-32574	312	6	precede	precede	VERB
ajst-32574	312	7	type	type	NOUN
ajst-32574	312	8	1	1	NUM
ajst-32574	312	9	diabetes	diabetes	NOUN
ajst-32574	312	10	.	.	PUNCT
ajst-32574	312	11	”	"	PUNCT
ajst-32574	313	1	scientific	scientific	ADJ
ajst-32574	313	2	reports	report	NOUN
ajst-32574	313	3	10	10	NUM
ajst-32574	313	4	,	,	PUNCT
ajst-32574	313	5	no	no	INTJ
ajst-32574	313	6	.	.	NOUN
ajst-32574	313	7	1	1	NUM
ajst-32574	313	8	(	(	PUNCT
ajst-32574	313	9	2020	2020	NUM
ajst-32574	313	10	):	):	PUNCT
ajst-32574	313	11	3721	3721	NUM
ajst-32574	313	12	.	.	PUNCT
ajst-32574	314	1	https://doi.org/10	https://doi.org/10	PROPN
ajst-32574	314	2	.	.	PUNCT
ajst-32574	315	1	1038/	1038/	NUM
ajst-32574	315	2	s41598	s41598	PROPN
ajst-32574	315	3	-	-	PUNCT
ajst-32574	315	4	020	020	NUM
ajst-32574	315	5	-	-	PUNCT
ajst-32574	315	6	60758	60758	NUM
ajst-32574	315	7	-	-	PUNCT
ajst-32574	315	8	0	0	NUM
ajst-32574	315	9	.	.	PUNCT
ajst-32574	316	1	[	[	X
ajst-32574	316	2	32	32	NUM
ajst-32574	316	3	]	]	SYM
ajst-32574	316	4	codazzi	codazzi	NOUN
ajst-32574	316	5	,	,	PUNCT
ajst-32574	316	6	valentina	valentina	PROPN
ajst-32574	316	7	,	,	PUNCT
ajst-32574	316	8	nicola	nicola	PROPN
ajst-32574	316	9	baldoni	baldoni	PROPN
ajst-32574	316	10	,	,	PUNCT
ajst-32574	316	11	giulia	giulia	PROPN
ajst-32574	316	12	m.	m.	PROPN
ajst-32574	316	13	scotti	scotti	PROPN
ajst-32574	316	14	,	,	PUNCT
ajst-32574	316	15	et	et	PROPN
ajst-32574	316	16	al	al	PROPN
ajst-32574	316	17	.	.	PUNCT
ajst-32574	317	1	“	"	PUNCT
ajst-32574	317	2	a	a	DET
ajst-32574	317	3	multi	multi	ADJ
ajst-32574	317	4	-	-	ADJ
ajst-32574	317	5	omics	omics	ADJ
ajst-32574	317	6	integration	integration	NOUN
ajst-32574	317	7	approach	approach	NOUN
ajst-32574	317	8	relying	rely	VERB
ajst-32574	317	9	on	on	ADP
ajst-32574	317	10	circulating	circulate	VERB
ajst-32574	317	11	factors	factor	NOUN
ajst-32574	317	12	does	do	AUX
ajst-32574	317	13	not	not	PART
ajst-32574	317	14	discern	discern	VERB
ajst-32574	317	15	subtypes	subtype	NOUN
ajst-32574	317	16	of	of	ADP
ajst-32574	317	17	childhood	childhood	NOUN
ajst-32574	317	18	type	type	NOUN
ajst-32574	317	19	1	1	NUM
ajst-32574	317	20	diabetes	diabetes	NOUN
ajst-32574	317	21	.	.	PUNCT
ajst-32574	317	22	”	"	PUNCT
ajst-32574	318	1	communications	communication	NOUN
ajst-32574	318	2	medicine	medicine	NOUN
ajst-32574	318	3	5	5	NUM
ajst-32574	318	4	,	,	PUNCT
ajst-32574	318	5	no	no	INTJ
ajst-32574	318	6	.	.	NOUN
ajst-32574	318	7	1	1	NUM
ajst-32574	318	8	(	(	PUNCT
ajst-32574	318	9	2025	2025	NUM
ajst-32574	318	10	):	):	PUNCT
ajst-32574	318	11	201	201	NUM
ajst-32574	318	12	.	.	PUNCT
ajst-32574	319	1	https://doi.org/10.1038/s43856-025-00922-7	https://doi.org/10.1038/s43856-025-00922-7	PROPN
ajst-32574	319	2	.	.	PUNCT
ajst-32574	320	1	[	[	X
ajst-32574	320	2	33	33	NUM
ajst-32574	320	3	]	]	X
ajst-32574	320	4	fyvie	fyvie	PROPN
ajst-32574	320	5	,	,	PUNCT
ajst-32574	320	6	maxwell	maxwell	PROPN
ajst-32574	320	7	j.	j.	PROPN
ajst-32574	320	8	,	,	PUNCT
ajst-32574	320	9	and	and	CCONJ
ajst-32574	320	10	kathleen	kathleen	PROPN
ajst-32574	320	11	m.	m.	PROPN
ajst-32574	320	12	gillespie	gillespie	PROPN
ajst-32574	320	13	.	.	PUNCT
ajst-32574	321	1	“	"	PUNCT
ajst-32574	321	2	the	the	DET
ajst-32574	321	3	importance	importance	NOUN
ajst-32574	321	4	of	of	ADP
ajst-32574	321	5	biomarker	biomarker	NOUN
ajst-32574	321	6	development	development	NOUN
ajst-32574	321	7	for	for	ADP
ajst-32574	321	8	monitoring	monitor	VERB
ajst-32574	321	9	type	type	NOUN
ajst-32574	321	10	1	1	NUM
ajst-32574	321	11	diabetes	diabetes	NOUN
ajst-32574	321	12	progression	progression	NOUN
ajst-32574	321	13	rate	rate	NOUN
ajst-32574	321	14	and	and	CCONJ
ajst-32574	321	15	therapeutic	therapeutic	ADJ
ajst-32574	321	16	responsiveness	responsiveness	NOUN
ajst-32574	321	17	.	.	PUNCT
ajst-32574	321	18	”	"	PUNCT
ajst-32574	321	19	frontiers	frontier	NOUN
ajst-32574	321	20	in	in	ADP
ajst-32574	321	21	immunology	immunology	NOUN
ajst-32574	321	22	14	14	NUM
ajst-32574	321	23	(	(	PUNCT
ajst-32574	321	24	2023	2023	NUM
ajst-32574	321	25	):	):	PUNCT
ajst-32574	321	26	1158278	1158278	NUM
ajst-32574	321	27	.	.	PUNCT
ajst-32574	322	1	https://doi.org/10.3389/fimmu.2023.1158278	https://doi.org/10.3389/fimmu.2023.1158278	PROPN
ajst-32574	322	2	.	.	PUNCT