id	sid	tid	token	lemma	pos
ajst-392	1	1	academic	academic	ADJ
ajst-392	1	2	journal	journal	NOUN
ajst-392	1	3	of	of	ADP
ajst-392	1	4	science	science	NOUN
ajst-392	1	5	and	and	CCONJ
ajst-392	1	6	technology	technology	NOUN
ajst-392	1	7	issn	issn	NOUN
ajst-392	1	8	:	:	PUNCT
ajst-392	1	9	2771	2771	NUM
ajst-392	1	10	-	-	SYM
ajst-392	1	11	3032	3032	NUM
ajst-392	1	12	|	|	NOUN
ajst-392	1	13	vol	vol	NOUN
ajst-392	1	14	.	.	PROPN
ajst-392	2	1	1	1	NUM
ajst-392	2	2	,	,	PUNCT
ajst-392	2	3	no	no	INTJ
ajst-392	2	4	.	.	NOUN
ajst-392	2	5	3	3	NUM
ajst-392	2	6	,	,	PUNCT
ajst-392	2	7	2022	2022	NUM
ajst-392	2	8	11	11	NUM
ajst-392	2	9	pacap	pacap	NOUN
ajst-392	2	10	improves	improve	VERB
ajst-392	2	11	macrophage	macrophage	ADJ
ajst-392	2	12	m1	m1	NOUN
ajst-392	2	13	polarization	polarization	NOUN
ajst-392	2	14	and	and	CCONJ
ajst-392	2	15	inflammatory	inflammatory	ADJ
ajst-392	2	16	response	response	NOUN
ajst-392	2	17	by	by	ADP
ajst-392	2	18	regulating	regulate	VERB
ajst-392	2	19	nf‐κb	nf‐κb	NOUN
ajst-392	2	20	and	and	CCONJ
ajst-392	2	21	mapks	mapks	NOUN
ajst-392	2	22	pathways	pathways	PROPN
ajst-392	2	23	qian	qian	PROPN
ajst-392	2	24	liu1	liu1	PROPN
ajst-392	2	25	,	,	PUNCT
ajst-392	2	26	2	2	NUM
ajst-392	2	27	,	,	PUNCT
ajst-392	2	28	jixiang	jixiang	PROPN
ajst-392	2	29	dong1	dong1	PROPN
ajst-392	2	30	,	,	PUNCT
ajst-392	2	31	2	2	NUM
ajst-392	2	32	,	,	PUNCT
ajst-392	2	33	jianmin	jianmin	PROPN
ajst-392	2	34	liu1	liu1	PROPN
ajst-392	2	35	,	,	PUNCT
ajst-392	2	36	2	2	NUM
ajst-392	2	37	,	,	PUNCT
ajst-392	2	38	chunyan	chunyan	NOUN
ajst-392	2	39	ji1	ji1	PROPN
ajst-392	2	40	,	,	PUNCT
ajst-392	2	41	2	2	NUM
ajst-392	2	42	,	,	PUNCT
ajst-392	2	43	haiqing	haiqe	VERB
ajst-392	2	44	zhou1	zhou1	NOUN
ajst-392	2	45	,	,	PUNCT
ajst-392	2	46	2	2	NUM
ajst-392	2	47	,	,	PUNCT
ajst-392	2	48	jiaxin	jiaxin	NOUN
ajst-392	2	49	dai1	dai1	PROPN
ajst-392	2	50	,	,	PUNCT
ajst-392	2	51	2	2	NUM
ajst-392	2	52	,	,	PUNCT
ajst-392	2	53	an	an	DET
ajst-392	2	54	hong1	hong1	NOUN
ajst-392	2	55	,	,	PUNCT
ajst-392	2	56	2	2	NUM
ajst-392	2	57	,	,	PUNCT
ajst-392	2	58	yi	yi	PROPN
ajst-392	2	59	ma1	ma1	PROPN
ajst-392	2	60	,	,	PUNCT
ajst-392	2	61	2	2	NUM
ajst-392	2	62	,	,	PUNCT
ajst-392	2	63	*	*	PUNCT
ajst-392	2	64	1institute	1institute	NUM
ajst-392	2	65	of	of	ADP
ajst-392	2	66	biomedicine	biomedicine	NOUN
ajst-392	2	67	,	,	PUNCT
ajst-392	2	68	department	department	NOUN
ajst-392	2	69	of	of	ADP
ajst-392	2	70	cellular	cellular	ADJ
ajst-392	2	71	biology	biology	NOUN
ajst-392	2	72	,	,	PUNCT
ajst-392	2	73	jinan	jinan	PROPN
ajst-392	2	74	university	university	PROPN
ajst-392	2	75	,	,	PUNCT
ajst-392	2	76	guangzhou	guangzhou	PROPN
ajst-392	2	77	,	,	PUNCT
ajst-392	2	78	people	people	NOUN
ajst-392	2	79	’s	’s	PART
ajst-392	2	80	republic	republic	NOUN
ajst-392	2	81	of	of	ADP
ajst-392	2	82	china	china	PROPN
ajst-392	2	83	2national	2national	NUM
ajst-392	2	84	engineering	engineering	NOUN
ajst-392	2	85	research	research	NOUN
ajst-392	2	86	center	center	NOUN
ajst-392	2	87	of	of	ADP
ajst-392	2	88	genetic	genetic	ADJ
ajst-392	2	89	medicine	medicine	NOUN
ajst-392	2	90	,	,	PUNCT
ajst-392	2	91	key	key	ADJ
ajst-392	2	92	laboratory	laboratory	NOUN
ajst-392	2	93	of	of	ADP
ajst-392	2	94	bioengineering	bioengineere	VERB
ajst-392	2	95	medicine	medicine	NOUN
ajst-392	2	96	of	of	ADP
ajst-392	2	97	guangdong	guangdong	PROPN
ajst-392	2	98	province	province	PROPN
ajst-392	2	99	,	,	PUNCT
ajst-392	2	100	jinan	jinan	PROPN
ajst-392	2	101	university	university	PROPN
ajst-392	2	102	,	,	PUNCT
ajst-392	2	103	guangzhou	guangzhou	PROPN
ajst-392	2	104	,	,	PUNCT
ajst-392	2	105	people	people	NOUN
ajst-392	2	106	’s	’s	PART
ajst-392	2	107	republic	republic	NOUN
ajst-392	2	108	of	of	ADP
ajst-392	2	109	china	china	PROPN
ajst-392	2	110	*	*	PUNCT
ajst-392	2	111	corresponding	correspond	VERB
ajst-392	2	112	author	author	NOUN
ajst-392	2	113	:	:	PUNCT
ajst-392	3	1	yi	yi	PROPN
ajst-392	3	2	ma	ma	PROPN
ajst-392	3	3	(	(	PUNCT
ajst-392	3	4	email	email	NOUN
ajst-392	3	5	:	:	PUNCT
ajst-392	3	6	tmayi@jnu.edu.cn	tmayi@jnu.edu.cn	NOUN
ajst-392	3	7	)	)	PUNCT
ajst-392	3	8	abstract	abstract	NOUN
ajst-392	3	9	:	:	PUNCT
ajst-392	3	10	inflammation	inflammation	NOUN
ajst-392	3	11	is	be	AUX
ajst-392	3	12	an	an	DET
ajst-392	3	13	important	important	ADJ
ajst-392	3	14	defense	defense	NOUN
ajst-392	3	15	mechanism	mechanism	NOUN
ajst-392	3	16	evolved	evolve	VERB
ajst-392	3	17	by	by	ADP
ajst-392	3	18	the	the	DET
ajst-392	3	19	host	host	NOUN
ajst-392	3	20	to	to	PART
ajst-392	3	21	defend	defend	VERB
ajst-392	3	22	against	against	ADP
ajst-392	3	23	external	external	ADJ
ajst-392	3	24	threats	threat	NOUN
ajst-392	3	25	.	.	PUNCT
ajst-392	4	1	but	but	CCONJ
ajst-392	4	2	an	an	DET
ajst-392	4	3	excessive	excessive	ADJ
ajst-392	4	4	inflammatory	inflammatory	ADJ
ajst-392	4	5	response	response	NOUN
ajst-392	4	6	can	can	AUX
ajst-392	4	7	lead	lead	VERB
ajst-392	4	8	to	to	ADP
ajst-392	4	9	a	a	DET
ajst-392	4	10	variety	variety	NOUN
ajst-392	4	11	of	of	ADP
ajst-392	4	12	inflammatory	inflammatory	ADJ
ajst-392	4	13	diseases	disease	NOUN
ajst-392	4	14	.	.	PUNCT
ajst-392	5	1	macrophage	macrophage	ADJ
ajst-392	5	2	m1	m1	NOUN
ajst-392	5	3	polarization	polarization	NOUN
ajst-392	5	4	is	be	AUX
ajst-392	5	5	a	a	DET
ajst-392	5	6	key	key	ADJ
ajst-392	5	7	factor	factor	NOUN
ajst-392	5	8	in	in	ADP
ajst-392	5	9	inducing	induce	VERB
ajst-392	5	10	inflammatory	inflammatory	ADJ
ajst-392	5	11	response	response	NOUN
ajst-392	5	12	,	,	PUNCT
ajst-392	5	13	and	and	CCONJ
ajst-392	5	14	inhibiting	inhibit	VERB
ajst-392	5	15	macrophage	macrophage	ADJ
ajst-392	5	16	m1	m1	NOUN
ajst-392	5	17	polarization	polarization	NOUN
ajst-392	5	18	is	be	AUX
ajst-392	5	19	of	of	ADP
ajst-392	5	20	great	great	ADJ
ajst-392	5	21	significance	significance	NOUN
ajst-392	5	22	for	for	ADP
ajst-392	5	23	regulating	regulate	VERB
ajst-392	5	24	inflammatory	inflammatory	ADJ
ajst-392	5	25	diseases	disease	NOUN
ajst-392	5	26	.	.	PUNCT
ajst-392	6	1	pacap	pacap	NOUN
ajst-392	6	2	is	be	AUX
ajst-392	6	3	an	an	DET
ajst-392	6	4	anti	anti	ADJ
ajst-392	6	5	-	-	ADJ
ajst-392	6	6	inflammatory	inflammatory	ADJ
ajst-392	6	7	neuropeptide	neuropeptide	NOUN
ajst-392	6	8	,	,	PUNCT
ajst-392	6	9	but	but	CCONJ
ajst-392	6	10	its	its	PRON
ajst-392	6	11	mechanism	mechanism	NOUN
ajst-392	6	12	of	of	ADP
ajst-392	6	13	action	action	NOUN
ajst-392	6	14	on	on	ADP
ajst-392	6	15	macrophage	macrophage	ADJ
ajst-392	6	16	polarization	polarization	NOUN
ajst-392	6	17	and	and	CCONJ
ajst-392	6	18	inflammatory	inflammatory	ADJ
ajst-392	6	19	responses	response	NOUN
ajst-392	6	20	is	be	AUX
ajst-392	6	21	unclear	unclear	ADJ
ajst-392	6	22	.	.	PUNCT
ajst-392	7	1	the	the	DET
ajst-392	7	2	macrophage	macrophage	ADJ
ajst-392	7	3	m1	m1	PROPN
ajst-392	7	4	polarization	polarization	NOUN
ajst-392	7	5	and	and	CCONJ
ajst-392	7	6	inflammation	inflammation	NOUN
ajst-392	7	7	model	model	NOUN
ajst-392	7	8	was	be	AUX
ajst-392	7	9	constructed	construct	VERB
ajst-392	7	10	using	use	VERB
ajst-392	7	11	lipopolysaccharide	lipopolysaccharide	ADJ
ajst-392	7	12	(	(	PUNCT
ajst-392	7	13	lps	lps	PROPN
ajst-392	7	14	)	)	PUNCT
ajst-392	7	15	,	,	PUNCT
ajst-392	7	16	and	and	CCONJ
ajst-392	7	17	then	then	ADV
ajst-392	7	18	treated	treat	VERB
ajst-392	7	19	with	with	ADP
ajst-392	7	20	pacap	pacap	NOUN
ajst-392	7	21	.	.	PUNCT
ajst-392	8	1	the	the	DET
ajst-392	8	2	results	result	NOUN
ajst-392	8	3	showed	show	VERB
ajst-392	8	4	that	that	SCONJ
ajst-392	8	5	pacap	pacap	NOUN
ajst-392	8	6	significantly	significantly	ADV
ajst-392	8	7	inhibited	inhibit	VERB
ajst-392	8	8	the	the	DET
ajst-392	8	9	lps	lps	PROPN
ajst-392	8	10	-	-	PUNCT
ajst-392	8	11	induced	induce	VERB
ajst-392	8	12	expression	expression	NOUN
ajst-392	8	13	of	of	ADP
ajst-392	8	14	m1	m1	PROPN
ajst-392	8	15	polarization	polarization	NOUN
ajst-392	8	16	marker	marker	NOUN
ajst-392	8	17	genes	gene	NOUN
ajst-392	8	18	and	and	CCONJ
ajst-392	8	19	inflammatory	inflammatory	ADJ
ajst-392	8	20	factors	factor	NOUN
ajst-392	8	21	in	in	ADP
ajst-392	8	22	macrophages	macrophage	NOUN
ajst-392	8	23	,	,	PUNCT
ajst-392	8	24	and	and	CCONJ
ajst-392	8	25	down	down	ADV
ajst-392	8	26	-	-	PUNCT
ajst-392	8	27	regulated	regulate	VERB
ajst-392	8	28	the	the	DET
ajst-392	8	29	phosphorylation	phosphorylation	NOUN
ajst-392	8	30	of	of	ADP
ajst-392	8	31	ikk2	ikk2	PROPN
ajst-392	8	32	/	/	SYM
ajst-392	8	33	iκbα	iκbα	ADV
ajst-392	8	34	/	/	SYM
ajst-392	8	35	nf	nf	NOUN
ajst-392	8	36	-	-	PUNCT
ajst-392	8	37	κb	κb	NOUN
ajst-392	8	38	,	,	PUNCT
ajst-392	8	39	while	while	SCONJ
ajst-392	8	40	pacap	pacap	NOUN
ajst-392	8	41	also	also	ADV
ajst-392	8	42	inhibited	inhibit	VERB
ajst-392	8	43	the	the	DET
ajst-392	8	44	phosphorylation	phosphorylation	NOUN
ajst-392	8	45	of	of	ADP
ajst-392	8	46	jnk	jnk	PROPN
ajst-392	8	47	/	/	SYM
ajst-392	8	48	p38	p38	NOUN
ajst-392	8	49	.	.	PUNCT
ajst-392	9	1	thus	thus	ADV
ajst-392	9	2	，	，	PUNCT
ajst-392	9	3	pacap	pacap	NOUN
ajst-392	9	4	improved	improve	VERB
ajst-392	9	5	lps	lps	PROPN
ajst-392	9	6	-	-	PUNCT
ajst-392	9	7	induced	induce	VERB
ajst-392	9	8	macrophage	macrophage	ADJ
ajst-392	9	9	m1	m1	NOUN
ajst-392	9	10	polarization	polarization	NOUN
ajst-392	9	11	and	and	CCONJ
ajst-392	9	12	inflammatory	inflammatory	ADJ
ajst-392	9	13	response	response	NOUN
ajst-392	9	14	by	by	ADP
ajst-392	9	15	regulating	regulate	VERB
ajst-392	9	16	nf	nf	PROPN
ajst-392	9	17	-	-	PUNCT
ajst-392	9	18	κb	κb	NOUN
ajst-392	9	19	and	and	CCONJ
ajst-392	9	20	mapks	mapks	NOUN
ajst-392	9	21	signaling	signal	VERB
ajst-392	9	22	pathways	pathway	NOUN
ajst-392	9	23	.	.	PUNCT
ajst-392	10	1	keywords	keyword	NOUN
ajst-392	10	2	:	:	PUNCT
ajst-392	10	3	pacap	pacap	NOUN
ajst-392	10	4	,	,	PUNCT
ajst-392	10	5	macrophage	macrophage	ADJ
ajst-392	10	6	m1	m1	NOUN
ajst-392	10	7	polarization	polarization	NOUN
ajst-392	10	8	,	,	PUNCT
ajst-392	10	9	nf	nf	NOUN
ajst-392	10	10	-	-	PUNCT
ajst-392	10	11	κb	κb	NOUN
ajst-392	10	12	,	,	PUNCT
ajst-392	10	13	mapks	mapks	NOUN
ajst-392	10	14	.	.	PROPN
ajst-392	10	15	1	1	NUM
ajst-392	10	16	.	.	X
ajst-392	11	1	introduction	introduction	NOUN
ajst-392	11	2	inflammation	inflammation	NOUN
ajst-392	11	3	is	be	AUX
ajst-392	11	4	an	an	DET
ajst-392	11	5	adaptive	adaptive	ADJ
ajst-392	11	6	defense	defense	NOUN
ajst-392	11	7	mechanism	mechanism	NOUN
ajst-392	11	8	evolved	evolve	VERB
ajst-392	11	9	by	by	ADP
ajst-392	11	10	the	the	DET
ajst-392	11	11	body	body	NOUN
ajst-392	11	12	[	[	X
ajst-392	11	13	1	1	NUM
ajst-392	11	14	]	]	PUNCT
ajst-392	11	15	.	.	PUNCT
ajst-392	12	1	inflammatory	inflammatory	ADJ
ajst-392	12	2	signals	signal	NOUN
ajst-392	12	3	such	such	ADJ
ajst-392	12	4	as	as	ADP
ajst-392	12	5	endotoxin	endotoxin	NOUN
ajst-392	12	6	activate	activate	VERB
ajst-392	12	7	immune	immune	ADJ
ajst-392	12	8	cells	cell	NOUN
ajst-392	12	9	,	,	PUNCT
ajst-392	12	10	initiate	initiate	VERB
ajst-392	12	11	immune	immune	ADJ
ajst-392	12	12	responses	response	NOUN
ajst-392	12	13	,	,	PUNCT
ajst-392	12	14	and	and	CCONJ
ajst-392	12	15	maintain	maintain	VERB
ajst-392	12	16	system	system	NOUN
ajst-392	12	17	homeostasis	homeostasis	NOUN
ajst-392	12	18	[	[	X
ajst-392	12	19	2	2	NUM
ajst-392	12	20	,	,	PUNCT
ajst-392	12	21	3	3	NUM
ajst-392	12	22	]	]	PUNCT
ajst-392	12	23	.	.	PUNCT
ajst-392	13	1	however	however	ADV
ajst-392	13	2	,	,	PUNCT
ajst-392	13	3	excessive	excessive	ADJ
ajst-392	13	4	inflammatory	inflammatory	ADJ
ajst-392	13	5	response	response	NOUN
ajst-392	13	6	will	will	AUX
ajst-392	13	7	damage	damage	VERB
ajst-392	13	8	the	the	DET
ajst-392	13	9	structure	structure	NOUN
ajst-392	13	10	and	and	CCONJ
ajst-392	13	11	function	function	NOUN
ajst-392	13	12	of	of	ADP
ajst-392	13	13	tissues	tissue	NOUN
ajst-392	13	14	,	,	PUNCT
ajst-392	13	15	gradually	gradually	ADV
ajst-392	13	16	form	form	VERB
ajst-392	13	17	chronic	chronic	ADJ
ajst-392	13	18	inflammation	inflammation	NOUN
ajst-392	13	19	characterized	characterize	VERB
ajst-392	13	20	by	by	ADP
ajst-392	13	21	macrophage	macrophage	ADJ
ajst-392	13	22	infiltration	infiltration	NOUN
ajst-392	13	23	,	,	PUNCT
ajst-392	13	24	and	and	CCONJ
ajst-392	13	25	further	further	ADJ
ajst-392	13	26	lead	lead	VERB
ajst-392	13	27	to	to	ADP
ajst-392	13	28	various	various	ADJ
ajst-392	13	29	inflammatory	inflammatory	ADJ
ajst-392	13	30	diseases	disease	NOUN
ajst-392	13	31	such	such	ADJ
ajst-392	13	32	as	as	ADP
ajst-392	13	33	obesity	obesity	NOUN
ajst-392	13	34	[	[	X
ajst-392	13	35	4	4	NUM
ajst-392	13	36	]	]	PUNCT
ajst-392	13	37	.	.	PUNCT
ajst-392	14	1	lipopolysaccharide(lps	lipopolysaccharide(lps	PROPN
ajst-392	14	2	)	)	PUNCT
ajst-392	14	3	is	be	AUX
ajst-392	14	4	a	a	DET
ajst-392	14	5	classic	classic	ADJ
ajst-392	14	6	bacterial	bacterial	ADJ
ajst-392	14	7	endotoxin	endotoxin	NOUN
ajst-392	14	8	and	and	CCONJ
ajst-392	14	9	an	an	DET
ajst-392	14	10	efficient	efficient	ADJ
ajst-392	14	11	inducer	inducer	NOUN
ajst-392	14	12	of	of	ADP
ajst-392	14	13	m1	m1	PROPN
ajst-392	14	14	polarization	polarization	NOUN
ajst-392	14	15	of	of	ADP
ajst-392	14	16	macrophages	macrophage	NOUN
ajst-392	14	17	[	[	X
ajst-392	14	18	5	5	NUM
ajst-392	14	19	]	]	PUNCT
ajst-392	14	20	,	,	PUNCT
ajst-392	14	21	which	which	PRON
ajst-392	14	22	can	can	AUX
ajst-392	14	23	induce	induce	VERB
ajst-392	14	24	the	the	DET
ajst-392	14	25	body	body	NOUN
ajst-392	14	26	to	to	PART
ajst-392	14	27	produce	produce	VERB
ajst-392	14	28	a	a	DET
ajst-392	14	29	non	non	ADJ
ajst-392	14	30	-	-	ADJ
ajst-392	14	31	specific	specific	ADJ
ajst-392	14	32	immune	immune	ADJ
ajst-392	14	33	response	response	NOUN
ajst-392	14	34	,	,	PUNCT
ajst-392	14	35	synthesize	synthesize	VERB
ajst-392	14	36	a	a	DET
ajst-392	14	37	large	large	ADJ
ajst-392	14	38	number	number	NOUN
ajst-392	14	39	of	of	ADP
ajst-392	14	40	inflammatory	inflammatory	ADJ
ajst-392	14	41	mediators	mediator	NOUN
ajst-392	14	42	,	,	PUNCT
ajst-392	14	43	and	and	CCONJ
ajst-392	14	44	trigger	trigger	VERB
ajst-392	14	45	a	a	DET
ajst-392	14	46	systemic	systemic	ADJ
ajst-392	14	47	inflammatory	inflammatory	ADJ
ajst-392	14	48	response	response	NOUN
ajst-392	14	49	.	.	PUNCT
ajst-392	15	1	lps	lps	PROPN
ajst-392	15	2	can	can	AUX
ajst-392	15	3	activate	activate	VERB
ajst-392	15	4	tlr4	tlr4	NOUN
ajst-392	15	5	on	on	ADP
ajst-392	15	6	the	the	DET
ajst-392	15	7	surface	surface	NOUN
ajst-392	15	8	of	of	ADP
ajst-392	15	9	macrophages	macrophage	NOUN
ajst-392	15	10	and	and	CCONJ
ajst-392	15	11	promote	promote	VERB
ajst-392	15	12	nf	nf	ADJ
ajst-392	15	13	-	-	PUNCT
ajst-392	15	14	κb	κb	NOUN
ajst-392	15	15	signaling	signal	VERB
ajst-392	15	16	[	[	X
ajst-392	15	17	6	6	NUM
ajst-392	15	18	,	,	PUNCT
ajst-392	15	19	7	7	NUM
ajst-392	15	20	]	]	PUNCT
ajst-392	15	21	.	.	PUNCT
ajst-392	16	1	in	in	ADP
ajst-392	16	2	the	the	DET
ajst-392	16	3	nf	nf	ADJ
ajst-392	16	4	-	-	PUNCT
ajst-392	16	5	κb	κb	NOUN
ajst-392	16	6	signaling	signal	VERB
ajst-392	16	7	pathway	pathway	NOUN
ajst-392	16	8	,	,	PUNCT
ajst-392	16	9	the	the	DET
ajst-392	16	10	ikk	ikk	PROPN
ajst-392	16	11	complex	complex	NOUN
ajst-392	16	12	can	can	AUX
ajst-392	16	13	regulate	regulate	VERB
ajst-392	16	14	the	the	DET
ajst-392	16	15	activity	activity	NOUN
ajst-392	16	16	of	of	ADP
ajst-392	16	17	downstream	downstream	ADJ
ajst-392	16	18	nf	nf	ADJ
ajst-392	16	19	-	-	PUNCT
ajst-392	16	20	κb	κb	ADJ
ajst-392	16	21	inhibitory	inhibitory	ADJ
ajst-392	16	22	molecules	molecule	NOUN
ajst-392	16	23	(	(	PUNCT
ajst-392	16	24	inhibitor	inhibitor	NOUN
ajst-392	16	25	of	of	ADP
ajst-392	16	26	nf	nf	NOUN
ajst-392	16	27	-	-	PUNCT
ajst-392	16	28	κb	κb	PROPN
ajst-392	16	29	,	,	PUNCT
ajst-392	16	30	iκb	iκb	NOUN
ajst-392	16	31	)	)	PUNCT
ajst-392	17	1	[	[	X
ajst-392	17	2	8	8	NUM
ajst-392	17	3	,	,	PUNCT
ajst-392	17	4	9	9	NUM
ajst-392	17	5	]	]	PUNCT
ajst-392	17	6	.	.	PUNCT
ajst-392	18	1	in	in	ADP
ajst-392	18	2	the	the	DET
ajst-392	18	3	non	non	ADJ
ajst-392	18	4	-	-	ADJ
ajst-392	18	5	stimulated	stimulated	ADJ
ajst-392	18	6	state	state	NOUN
ajst-392	18	7	,	,	PUNCT
ajst-392	18	8	nf	nf	ADJ
ajst-392	18	9	-	-	PUNCT
ajst-392	18	10	κb	κb	PROPN
ajst-392	18	11	binds	bind	VERB
ajst-392	18	12	to	to	ADP
ajst-392	18	13	iκb	iκb	NOUN
ajst-392	18	14	in	in	ADP
ajst-392	18	15	an	an	DET
ajst-392	18	16	inactive	inactive	ADJ
ajst-392	18	17	form	form	NOUN
ajst-392	18	18	and	and	CCONJ
ajst-392	18	19	binds	bind	VERB
ajst-392	18	20	to	to	ADP
ajst-392	18	21	the	the	DET
ajst-392	18	22	cytoplasm	cytoplasm	NOUN
ajst-392	18	23	;	;	PUNCT
ajst-392	18	24	after	after	ADP
ajst-392	18	25	stimulation	stimulation	NOUN
ajst-392	18	26	,	,	PUNCT
ajst-392	18	27	iκb	iκb	NOUN
ajst-392	18	28	is	be	AUX
ajst-392	18	29	phosphorylated	phosphorylate	VERB
ajst-392	18	30	and	and	CCONJ
ajst-392	18	31	degraded	degrade	VERB
ajst-392	18	32	through	through	ADP
ajst-392	18	33	the	the	DET
ajst-392	18	34	proteasome	proteasome	NOUN
ajst-392	18	35	pathway	pathway	NOUN
ajst-392	18	36	,	,	PUNCT
ajst-392	18	37	releasing	release	VERB
ajst-392	18	38	the	the	DET
ajst-392	18	39	inhibitory	inhibitory	ADJ
ajst-392	18	40	effect	effect	NOUN
ajst-392	18	41	on	on	ADP
ajst-392	18	42	nf	nf	NOUN
ajst-392	18	43	-	-	PUNCT
ajst-392	18	44	κb	κb	ADJ
ajst-392	18	45	,	,	PUNCT
ajst-392	18	46	nf	nf	ADJ
ajst-392	18	47	-	-	PUNCT
ajst-392	18	48	κb	κb	ADJ
ajst-392	18	49	p65	p65	NOUN
ajst-392	18	50	/p50	/p50	PUNCT
ajst-392	18	51	heterodimer	heterodimer	PROPN
ajst-392	18	52	translocates	translocate	NOUN
ajst-392	18	53	into	into	ADP
ajst-392	18	54	the	the	DET
ajst-392	18	55	nucleus	nucleus	NOUN
ajst-392	18	56	and	and	CCONJ
ajst-392	18	57	binds	bind	VERB
ajst-392	18	58	to	to	ADP
ajst-392	18	59	the	the	DET
ajst-392	18	60	corresponding	correspond	VERB
ajst-392	18	61	site	site	NOUN
ajst-392	18	62	of	of	ADP
ajst-392	18	63	the	the	DET
ajst-392	18	64	target	target	NOUN
ajst-392	18	65	gene	gene	NOUN
ajst-392	18	66	dna	dna	NOUN
ajst-392	18	67	,	,	PUNCT
ajst-392	18	68	regulates	regulate	VERB
ajst-392	18	69	the	the	DET
ajst-392	18	70	mrna	mrna	PROPN
ajst-392	18	71	transcription	transcription	NOUN
ajst-392	18	72	of	of	ADP
ajst-392	18	73	the	the	DET
ajst-392	18	74	target	target	NOUN
ajst-392	18	75	gene	gene	NOUN
ajst-392	18	76	,	,	PUNCT
ajst-392	18	77	induces	induce	VERB
ajst-392	18	78	the	the	DET
ajst-392	18	79	expression	expression	NOUN
ajst-392	18	80	of	of	ADP
ajst-392	18	81	pro	pro	ADJ
ajst-392	18	82	-	-	ADJ
ajst-392	18	83	inflammatory	inflammatory	ADJ
ajst-392	18	84	factors	factor	NOUN
ajst-392	18	85	,	,	PUNCT
ajst-392	18	86	and	and	CCONJ
ajst-392	18	87	then	then	ADV
ajst-392	18	88	triggers	trigger	VERB
ajst-392	18	89	the	the	DET
ajst-392	18	90	m1	m1	PROPN
ajst-392	18	91	polarization	polarization	NOUN
ajst-392	18	92	of	of	ADP
ajst-392	18	93	macrophages	macrophage	NOUN
ajst-392	18	94	[	[	X
ajst-392	18	95	10	10	NUM
ajst-392	18	96	,	,	PUNCT
ajst-392	18	97	11	11	NUM
ajst-392	18	98	]	]	PUNCT
ajst-392	18	99	.	.	PUNCT
ajst-392	19	1	in	in	ADP
ajst-392	19	2	addition	addition	NOUN
ajst-392	19	3	,	,	PUNCT
ajst-392	19	4	tlr4	tlr4	NOUN
ajst-392	19	5	also	also	ADV
ajst-392	19	6	mediates	mediate	VERB
ajst-392	19	7	the	the	DET
ajst-392	19	8	activation	activation	NOUN
ajst-392	19	9	of	of	ADP
ajst-392	19	10	downstream	downstream	ADJ
ajst-392	19	11	mitogenactivated	mitogenactivate	VERB
ajst-392	19	12	protein	protein	NOUN
ajst-392	19	13	kinase	kinase	PROPN
ajst-392	19	14	(	(	PUNCT
ajst-392	19	15	mapk	mapk	NOUN
ajst-392	19	16	)	)	PUNCT
ajst-392	19	17	family	family	NOUN
ajst-392	19	18	(	(	PUNCT
ajst-392	19	19	jnk	jnk	PROPN
ajst-392	19	20	,	,	PUNCT
ajst-392	19	21	p38	p38	NOUN
ajst-392	19	22	,	,	PUNCT
ajst-392	19	23	etc	etc	X
ajst-392	19	24	.	.	X
ajst-392	19	25	)	)	PUNCT
ajst-392	20	1	[	[	X
ajst-392	20	2	12	12	NUM
ajst-392	20	3	]	]	PUNCT
ajst-392	20	4	.	.	PUNCT
ajst-392	20	5	activated	activate	VERB
ajst-392	20	6	jnk	jnk	PROPN
ajst-392	20	7	and	and	CCONJ
ajst-392	20	8	p38	p38	NOUN
ajst-392	20	9	can	can	AUX
ajst-392	20	10	mediate	mediate	VERB
ajst-392	20	11	the	the	DET
ajst-392	20	12	activity	activity	NOUN
ajst-392	20	13	regulation	regulation	NOUN
ajst-392	20	14	of	of	ADP
ajst-392	20	15	the	the	DET
ajst-392	20	16	downstream	downstream	ADJ
ajst-392	20	17	key	key	ADJ
ajst-392	20	18	transcription	transcription	NOUN
ajst-392	20	19	factor	factor	NOUN
ajst-392	20	20	activating	activate	VERB
ajst-392	20	21	protein-1	protein-1	NUM
ajst-392	20	22	(	(	PUNCT
ajst-392	20	23	ap-1	ap-1	NOUN
ajst-392	20	24	)	)	PUNCT
ajst-392	21	1	[	[	X
ajst-392	21	2	13	13	NUM
ajst-392	21	3	,	,	PUNCT
ajst-392	21	4	14	14	NUM
ajst-392	21	5	]	]	PUNCT
ajst-392	21	6	,	,	PUNCT
ajst-392	21	7	which	which	PRON
ajst-392	21	8	induces	induce	VERB
ajst-392	21	9	the	the	DET
ajst-392	21	10	expression	expression	NOUN
ajst-392	21	11	of	of	ADP
ajst-392	21	12	various	various	ADJ
ajst-392	21	13	proinflammatory	proinflammatory	ADJ
ajst-392	21	14	factors	factor	NOUN
ajst-392	21	15	at	at	ADP
ajst-392	21	16	the	the	DET
ajst-392	21	17	gene	gene	NOUN
ajst-392	21	18	level	level	NOUN
ajst-392	21	19	and	and	CCONJ
ajst-392	21	20	promotes	promote	VERB
ajst-392	21	21	m1	m1	NOUN
ajst-392	21	22	-	-	PUNCT
ajst-392	21	23	type	type	NOUN
ajst-392	21	24	polarization	polarization	NOUN
ajst-392	21	25	of	of	ADP
ajst-392	21	26	macrophages	macrophage	NOUN
ajst-392	21	27	[	[	X
ajst-392	21	28	15	15	NUM
ajst-392	21	29	]	]	PUNCT
ajst-392	21	30	.	.	PUNCT
ajst-392	22	1	this	this	PRON
ajst-392	22	2	suggests	suggest	VERB
ajst-392	22	3	that	that	SCONJ
ajst-392	22	4	targeting	target	VERB
ajst-392	22	5	nf	nf	NOUN
ajst-392	22	6	-	-	PUNCT
ajst-392	22	7	κb	κb	NOUN
ajst-392	22	8	/	/	SYM
ajst-392	22	9	mapks	mapks	NOUN
ajst-392	22	10	may	may	AUX
ajst-392	22	11	improve	improve	VERB
ajst-392	22	12	macrophage	macrophage	ADJ
ajst-392	22	13	-	-	PUNCT
ajst-392	22	14	mediated	mediate	VERB
ajst-392	22	15	inflammatory	inflammatory	ADJ
ajst-392	22	16	responses	response	NOUN
ajst-392	22	17	.	.	PUNCT
ajst-392	23	1	most	most	ADJ
ajst-392	23	2	of	of	ADP
ajst-392	23	3	the	the	DET
ajst-392	23	4	anti	anti	ADJ
ajst-392	23	5	-	-	ADJ
ajst-392	23	6	inflammatory	inflammatory	ADJ
ajst-392	23	7	drugs	drug	NOUN
ajst-392	23	8	currently	currently	ADV
ajst-392	23	9	in	in	ADP
ajst-392	23	10	use	use	NOUN
ajst-392	23	11	have	have	VERB
ajst-392	23	12	obvious	obvious	ADJ
ajst-392	23	13	side	side	NOUN
ajst-392	23	14	effects	effect	NOUN
ajst-392	23	15	,	,	PUNCT
ajst-392	23	16	which	which	PRON
ajst-392	23	17	may	may	AUX
ajst-392	23	18	lead	lead	VERB
ajst-392	23	19	to	to	ADP
ajst-392	23	20	general	general	ADJ
ajst-392	23	21	gastrointestinal	gastrointestinal	ADJ
ajst-392	23	22	toxicity	toxicity	NOUN
ajst-392	23	23	and	and	CCONJ
ajst-392	23	24	increase	increase	VERB
ajst-392	23	25	the	the	DET
ajst-392	23	26	risk	risk	NOUN
ajst-392	23	27	of	of	ADP
ajst-392	23	28	cardiovascular	cardiovascular	ADJ
ajst-392	23	29	disease	disease	NOUN
ajst-392	23	30	[	[	X
ajst-392	23	31	16	16	NUM
ajst-392	23	32	,	,	PUNCT
ajst-392	23	33	17	17	NUM
ajst-392	23	34	]	]	PUNCT
ajst-392	23	35	.	.	PUNCT
ajst-392	24	1	many	many	ADJ
ajst-392	24	2	drugs	drug	NOUN
ajst-392	24	3	have	have	AUX
ajst-392	24	4	been	be	AUX
ajst-392	24	5	reduced	reduce	VERB
ajst-392	24	6	or	or	CCONJ
ajst-392	24	7	even	even	ADV
ajst-392	24	8	banned	ban	VERB
ajst-392	24	9	from	from	ADP
ajst-392	24	10	clinical	clinical	ADJ
ajst-392	24	11	use	use	NOUN
ajst-392	24	12	due	due	ADP
ajst-392	24	13	to	to	ADP
ajst-392	24	14	obvious	obvious	ADJ
ajst-392	24	15	toxic	toxic	ADJ
ajst-392	24	16	side	side	NOUN
ajst-392	24	17	effects	effect	NOUN
ajst-392	24	18	[	[	X
ajst-392	24	19	18–21	18–21	NUM
ajst-392	24	20	]	]	PUNCT
ajst-392	24	21	.	.	PUNCT
ajst-392	25	1	the	the	DET
ajst-392	25	2	quantity	quantity	NOUN
ajst-392	25	3	and	and	CCONJ
ajst-392	25	4	safety	safety	NOUN
ajst-392	25	5	of	of	ADP
ajst-392	25	6	antiinflammatory	antiinflammatory	NOUN
ajst-392	25	7	drugs	drug	NOUN
ajst-392	25	8	are	be	AUX
ajst-392	25	9	still	still	ADV
ajst-392	25	10	limited	limited	ADJ
ajst-392	25	11	,	,	PUNCT
ajst-392	25	12	so	so	CCONJ
ajst-392	25	13	it	it	PRON
ajst-392	25	14	is	be	AUX
ajst-392	25	15	necessary	necessary	ADJ
ajst-392	25	16	to	to	PART
ajst-392	25	17	develop	develop	VERB
ajst-392	25	18	more	more	ADV
ajst-392	25	19	safe	safe	ADJ
ajst-392	25	20	and	and	CCONJ
ajst-392	25	21	effective	effective	ADJ
ajst-392	25	22	new	new	ADJ
ajst-392	25	23	anti	anti	ADJ
ajst-392	25	24	-	-	ADJ
ajst-392	25	25	inflammatory	inflammatory	ADJ
ajst-392	25	26	drugs	drug	NOUN
ajst-392	25	27	.	.	PUNCT
ajst-392	26	1	pacap	pacap	NOUN
ajst-392	26	2	,	,	PUNCT
ajst-392	26	3	a	a	DET
ajst-392	26	4	neuropeptide	neuropeptide	NOUN
ajst-392	26	5	isolated	isolate	VERB
ajst-392	26	6	from	from	ADP
ajst-392	26	7	the	the	DET
ajst-392	26	8	ovine	ovine	ADJ
ajst-392	26	9	hypothalamus	hypothalamus	NOUN
ajst-392	27	1	[	[	X
ajst-392	27	2	22	22	NUM
ajst-392	27	3	]	]	PUNCT
ajst-392	27	4	,	,	PUNCT
ajst-392	27	5	has	have	VERB
ajst-392	27	6	general	general	ADJ
ajst-392	27	7	anti	anti	ADJ
ajst-392	27	8	-	-	ADJ
ajst-392	27	9	inflammatory	inflammatory	ADJ
ajst-392	27	10	activity	activity	NOUN
ajst-392	27	11	,	,	PUNCT
ajst-392	27	12	but	but	CCONJ
ajst-392	27	13	the	the	DET
ajst-392	27	14	molecular	molecular	ADJ
ajst-392	27	15	mechanism	mechanism	NOUN
ajst-392	27	16	of	of	ADP
ajst-392	27	17	its	its	PRON
ajst-392	27	18	inhibition	inhibition	NOUN
ajst-392	27	19	of	of	ADP
ajst-392	27	20	macrophage	macrophage	ADJ
ajst-392	27	21	m1	m1	NOUN
ajst-392	27	22	polarization	polarization	NOUN
ajst-392	27	23	is	be	AUX
ajst-392	27	24	unclear	unclear	ADJ
ajst-392	27	25	.	.	PUNCT
ajst-392	28	1	therefore	therefore	ADV
ajst-392	28	2	,	,	PUNCT
ajst-392	28	3	this	this	DET
ajst-392	28	4	study	study	NOUN
ajst-392	28	5	verifies	verify	VERB
ajst-392	28	6	the	the	DET
ajst-392	28	7	antiinflammatory	antiinflammatory	NOUN
ajst-392	28	8	effect	effect	NOUN
ajst-392	28	9	of	of	ADP
ajst-392	28	10	pacap	pacap	NOUN
ajst-392	28	11	,	,	PUNCT
ajst-392	28	12	clarifies	clarify	VERB
ajst-392	28	13	the	the	DET
ajst-392	28	14	mechanism	mechanism	NOUN
ajst-392	28	15	of	of	ADP
ajst-392	28	16	pacap	pacap	NOUN
ajst-392	28	17	in	in	ADP
ajst-392	28	18	improving	improve	VERB
ajst-392	28	19	lipopolysaccharide	lipopolysaccharide	ADV
ajst-392	28	20	-	-	PUNCT
ajst-392	28	21	induced	induce	VERB
ajst-392	28	22	macrophage	macrophage	ADJ
ajst-392	28	23	m1	m1	NOUN
ajst-392	28	24	polarization	polarization	NOUN
ajst-392	28	25	and	and	CCONJ
ajst-392	28	26	inflammatory	inflammatory	ADJ
ajst-392	28	27	response	response	NOUN
ajst-392	28	28	,	,	PUNCT
ajst-392	28	29	and	and	CCONJ
ajst-392	28	30	provides	provide	VERB
ajst-392	28	31	new	new	ADJ
ajst-392	28	32	ideas	idea	NOUN
ajst-392	28	33	for	for	ADP
ajst-392	28	34	the	the	DET
ajst-392	28	35	development	development	NOUN
ajst-392	28	36	of	of	ADP
ajst-392	28	37	new	new	ADJ
ajst-392	28	38	antiinflammatory	antiinflammatory	NOUN
ajst-392	28	39	drugs	drug	NOUN
ajst-392	28	40	.	.	PUNCT
ajst-392	29	1	2	2	X
ajst-392	29	2	.	.	X
ajst-392	29	3	materials	material	NOUN
ajst-392	29	4	and	and	CCONJ
ajst-392	29	5	methods	method	NOUN
ajst-392	29	6	2.1	2.1	NUM
ajst-392	29	7	.	.	PUNCT
ajst-392	30	1	cell	cell	NOUN
ajst-392	30	2	culture	culture	NOUN
ajst-392	30	3	mouse	mouse	PROPN
ajst-392	30	4	raw264.7	raw264.7	PROPN
ajst-392	30	5	cells	cell	NOUN
ajst-392	30	6	were	be	AUX
ajst-392	30	7	obtained	obtain	VERB
ajst-392	30	8	from	from	ADP
ajst-392	30	9	wuhan	wuhan	PROPN
ajst-392	30	10	cell	cell	PROPN
ajst-392	30	11	bank	bank	PROPN
ajst-392	30	12	and	and	CCONJ
ajst-392	30	13	cultured	cultured	ADJ
ajst-392	30	14	in	in	ADP
ajst-392	30	15	dulbecco	dulbecco	NOUN
ajst-392	30	16	’s	’s	PART
ajst-392	30	17	modified	modified	PROPN
ajst-392	30	18	eagle	eagle	PROPN
ajst-392	30	19	’s	’s	PART
ajst-392	30	20	medium	medium	ADJ
ajst-392	30	21	(	(	PUNCT
ajst-392	30	22	thermo	thermo	NOUN
ajst-392	30	23	,	,	PUNCT
ajst-392	30	24	ma	ma	PROPN
ajst-392	30	25	,	,	PUNCT
ajst-392	30	26	usa	usa	PROPN
ajst-392	30	27	)	)	PUNCT
ajst-392	30	28	containing	contain	VERB
ajst-392	30	29	10	10	NUM
ajst-392	30	30	%	%	NOUN
ajst-392	30	31	fetal	fetal	ADJ
ajst-392	30	32	bovine	bovine	NOUN
ajst-392	30	33	serum	serum	NOUN
ajst-392	30	34	(	(	PUNCT
ajst-392	30	35	thermo	thermo	NOUN
ajst-392	30	36	,	,	PUNCT
ajst-392	30	37	ma	ma	PROPN
ajst-392	30	38	,	,	PUNCT
ajst-392	30	39	usa	usa	PROPN
ajst-392	30	40	)	)	PUNCT
ajst-392	30	41	,	,	PUNCT
ajst-392	30	42	penicillin	penicillin	NOUN
ajst-392	30	43	(	(	PUNCT
ajst-392	30	44	100	100	NUM
ajst-392	30	45	u	u	NOUN
ajst-392	30	46	/	/	SYM
ajst-392	30	47	ml	ml	NOUN
ajst-392	30	48	)	)	PUNCT
ajst-392	30	49	,	,	PUNCT
ajst-392	30	50	streptomycin	streptomycin	PROPN
ajst-392	30	51	(	(	PUNCT
ajst-392	30	52	100	100	NUM
ajst-392	30	53	μg	μg	NOUN
ajst-392	30	54	/	/	SYM
ajst-392	30	55	ml	ml	NOUN
ajst-392	30	56	)	)	PUNCT
ajst-392	30	57	and	and	CCONJ
ajst-392	30	58	2	2	NUM
ajst-392	30	59	mm	mm	NOUN
ajst-392	30	60	l	l	NOUN
ajst-392	30	61	-	-	NOUN
ajst-392	30	62	glutamine	glutamine	NOUN
ajst-392	30	63	.	.	PUNCT
ajst-392	31	1	cells	cell	NOUN
ajst-392	31	2	were	be	AUX
ajst-392	31	3	cultured	cultured	ADJ
ajst-392	31	4	at	at	ADP
ajst-392	31	5	37	37	NUM
ajst-392	31	6	°	°	ADP
ajst-392	31	7	c	c	NOUN
ajst-392	31	8	in	in	ADP
ajst-392	31	9	a	a	DET
ajst-392	31	10	humidified	humidify	VERB
ajst-392	31	11	atmosphere	atmosphere	NOUN
ajst-392	31	12	containing	contain	VERB
ajst-392	31	13	5	5	NUM
ajst-392	31	14	%	%	NOUN
ajst-392	31	15	co2	co2	NOUN
ajst-392	31	16	.	.	PUNCT
ajst-392	32	1	2.2	2.2	NUM
ajst-392	32	2	.	.	PUNCT
ajst-392	32	3	cell	cell	NOUN
ajst-392	32	4	viability	viability	NOUN
ajst-392	32	5	assay	assay	VERB
ajst-392	32	6	the	the	DET
ajst-392	32	7	effect	effect	NOUN
ajst-392	32	8	of	of	ADP
ajst-392	32	9	pacap	pacap	NOUN
ajst-392	32	10	on	on	ADP
ajst-392	32	11	the	the	DET
ajst-392	32	12	viability	viability	NOUN
ajst-392	32	13	of	of	ADP
ajst-392	32	14	raw264.7	raw264.7	PROPN
ajst-392	32	15	cells	cell	NOUN
ajst-392	32	16	was	be	AUX
ajst-392	32	17	evaluated	evaluate	VERB
ajst-392	32	18	by	by	ADP
ajst-392	32	19	cck-8	cck-8	PUNCT
ajst-392	32	20	method	method	NOUN
ajst-392	32	21	.	.	PUNCT
ajst-392	33	1	the	the	DET
ajst-392	33	2	cells	cell	NOUN
ajst-392	33	3	were	be	AUX
ajst-392	33	4	seeded	seed	VERB
ajst-392	33	5	in	in	ADP
ajst-392	33	6	a	a	DET
ajst-392	33	7	12	12	NUM
ajst-392	33	8	96	96	NUM
ajst-392	33	9	-	-	PUNCT
ajst-392	33	10	well	well	NOUN
ajst-392	33	11	plate	plate	NOUN
ajst-392	33	12	at	at	ADP
ajst-392	33	13	a	a	DET
ajst-392	33	14	density	density	NOUN
ajst-392	33	15	of	of	ADP
ajst-392	33	16	8	8	NUM
ajst-392	33	17	×	×	NOUN
ajst-392	33	18	103	103	NUM
ajst-392	33	19	cells	cell	NOUN
ajst-392	33	20	/	/	SYM
ajst-392	33	21	well	well	ADV
ajst-392	33	22	,	,	PUNCT
ajst-392	33	23	treated	treat	VERB
ajst-392	33	24	with	with	ADP
ajst-392	33	25	different	different	ADJ
ajst-392	33	26	concentrations	concentration	NOUN
ajst-392	33	27	of	of	ADP
ajst-392	33	28	pacap	pacap	NOUN
ajst-392	33	29	for	for	ADP
ajst-392	33	30	24	24	NUM
ajst-392	33	31	h	h	NOUN
ajst-392	33	32	,	,	PUNCT
ajst-392	33	33	and	and	CCONJ
ajst-392	33	34	the	the	DET
ajst-392	33	35	culture	culture	NOUN
ajst-392	33	36	medium	medium	NOUN
ajst-392	33	37	was	be	AUX
ajst-392	33	38	discarded	discard	VERB
ajst-392	33	39	,	,	PUNCT
ajst-392	33	40	and	and	CCONJ
ajst-392	33	41	100	100	NUM
ajst-392	33	42	μl	μl	ADP
ajst-392	33	43	of	of	ADP
ajst-392	33	44	working	work	VERB
ajst-392	33	45	solution	solution	NOUN
ajst-392	33	46	(	(	PUNCT
ajst-392	33	47	containing	contain	VERB
ajst-392	33	48	10	10	NUM
ajst-392	33	49	μl	μl	ADP
ajst-392	33	50	of	of	ADP
ajst-392	33	51	cck-8	cck-8	PUNCT
ajst-392	33	52	reagent	reagent	NOUN
ajst-392	33	53	)	)	PUNCT
ajst-392	33	54	was	be	AUX
ajst-392	33	55	added	add	VERB
ajst-392	33	56	to	to	ADP
ajst-392	33	57	each	each	DET
ajst-392	33	58	well	well	ADV
ajst-392	33	59	.	.	PUNCT
ajst-392	34	1	after	after	SCONJ
ajst-392	34	2	incubation	incubation	NOUN
ajst-392	34	3	at	at	ADP
ajst-392	34	4	37	37	NUM
ajst-392	34	5	℃	℃	PROPN
ajst-392	34	6	for	for	ADP
ajst-392	34	7	60	60	NUM
ajst-392	34	8	-	-	SYM
ajst-392	34	9	120	120	NUM
ajst-392	34	10	min	min	NOUN
ajst-392	34	11	,	,	PUNCT
ajst-392	34	12	the	the	DET
ajst-392	34	13	absorbance	absorbance	NOUN
ajst-392	34	14	at	at	ADP
ajst-392	34	15	450	450	NUM
ajst-392	34	16	nm	nm	NOUN
ajst-392	34	17	was	be	AUX
ajst-392	34	18	detected	detect	VERB
ajst-392	34	19	with	with	ADP
ajst-392	34	20	a	a	DET
ajst-392	34	21	microplate	microplate	NOUN
ajst-392	34	22	reader	reader	NOUN
ajst-392	34	23	(	(	PUNCT
ajst-392	34	24	bio	bio	NOUN
ajst-392	34	25	-	-	PROPN
ajst-392	34	26	rad	rad	PROPN
ajst-392	34	27	,	,	PUNCT
ajst-392	34	28	ca	ca	PROPN
ajst-392	34	29	,	,	PUNCT
ajst-392	34	30	usa	usa	PROPN
ajst-392	34	31	)	)	PUNCT
ajst-392	34	32	.	.	PUNCT
ajst-392	35	1	2.3	2.3	NUM
ajst-392	35	2	.	.	PUNCT
ajst-392	36	1	no	no	DET
ajst-392	36	2	assay	assay	NOUN
ajst-392	36	3	the	the	DET
ajst-392	36	4	operation	operation	NOUN
ajst-392	36	5	was	be	AUX
ajst-392	36	6	carried	carry	VERB
ajst-392	36	7	out	out	ADP
ajst-392	36	8	according	accord	VERB
ajst-392	36	9	to	to	ADP
ajst-392	36	10	the	the	DET
ajst-392	36	11	protocol	protocol	NOUN
ajst-392	36	12	of	of	ADP
ajst-392	36	13	biyuntian	biyuntian	PROPN
ajst-392	36	14	total	total	ADJ
ajst-392	36	15	nitric	nitric	ADJ
ajst-392	36	16	oxide	oxide	NOUN
ajst-392	36	17	detection	detection	NOUN
ajst-392	36	18	kit	kit	NOUN
ajst-392	36	19	(	(	PUNCT
ajst-392	36	20	biyuntian	biyuntian	PROPN
ajst-392	36	21	,	,	PUNCT
ajst-392	36	22	shanghai	shanghai	PROPN
ajst-392	36	23	,	,	PUNCT
ajst-392	36	24	china	china	PROPN
ajst-392	36	25	)	)	PUNCT
ajst-392	36	26	.	.	PUNCT
ajst-392	37	1	2.4	2.4	NUM
ajst-392	37	2	.	.	PUNCT
ajst-392	38	1	rna	rna	NOUN
ajst-392	38	2	extraction	extraction	NOUN
ajst-392	38	3	and	and	CCONJ
ajst-392	38	4	real	real	ADJ
ajst-392	38	5	-	-	PUNCT
ajst-392	38	6	time	time	NOUN
ajst-392	38	7	pcr	pcr	NOUN
ajst-392	38	8	rnaiso	rnaiso	NOUN
ajst-392	38	9	plus	plus	CCONJ
ajst-392	38	10	(	(	PUNCT
ajst-392	38	11	takara	takara	PROPN
ajst-392	38	12	,	,	PUNCT
ajst-392	38	13	kyoto	kyoto	PROPN
ajst-392	38	14	,	,	PUNCT
ajst-392	38	15	japan	japan	PROPN
ajst-392	38	16	)	)	PUNCT
ajst-392	38	17	,	,	PUNCT
ajst-392	38	18	primescript	primescript	NOUN
ajst-392	38	19	rt	rt	PROPN
ajst-392	38	20	reagent	reagent	ADJ
ajst-392	38	21	kit	kit	NOUN
ajst-392	38	22	with	with	ADP
ajst-392	38	23	gdna	gdna	PROPN
ajst-392	38	24	eraser	eraser	NOUN
ajst-392	38	25	(	(	PUNCT
ajst-392	38	26	takara	takara	PROPN
ajst-392	38	27	,	,	PUNCT
ajst-392	38	28	kyoto	kyoto	PROPN
ajst-392	38	29	,	,	PUNCT
ajst-392	38	30	japan	japan	PROPN
ajst-392	38	31	)	)	PUNCT
ajst-392	38	32	were	be	AUX
ajst-392	38	33	used	use	VERB
ajst-392	38	34	to	to	PART
ajst-392	38	35	extract	extract	VERB
ajst-392	38	36	and	and	CCONJ
ajst-392	38	37	reverse	reverse	VERB
ajst-392	38	38	transcribe	transcribe	VERB
ajst-392	38	39	total	total	ADJ
ajst-392	38	40	mrna	mrna	NOUN
ajst-392	38	41	in	in	ADP
ajst-392	38	42	raw264.7	raw264.7	PROPN
ajst-392	38	43	cells	cell	NOUN
ajst-392	38	44	.	.	PUNCT
ajst-392	39	1	and	and	CCONJ
ajst-392	39	2	rt	rt	NOUN
ajst-392	39	3	-	-	PUNCT
ajst-392	39	4	qpcr	qpcr	ADV
ajst-392	39	5	was	be	AUX
ajst-392	39	6	performed	perform	VERB
ajst-392	39	7	.	.	PUNCT
ajst-392	40	1	the	the	DET
ajst-392	40	2	primer	primer	NOUN
ajst-392	40	3	sequences	sequence	NOUN
ajst-392	40	4	for	for	ADP
ajst-392	40	5	each	each	DET
ajst-392	40	6	gene	gene	NOUN
ajst-392	40	7	are	be	AUX
ajst-392	40	8	shown	show	VERB
ajst-392	40	9	below	below	ADP
ajst-392	40	10	:	:	PUNCT
ajst-392	41	1	arg1	arg1	NOUN
ajst-392	41	2	:	:	PUNCT
ajst-392	41	3	forward	forward	ADV
ajst-392	41	4	5	5	NUM
ajst-392	41	5	ccacagtctggcagttggaag-3	ccacagtctggcagttggaag-3	NUM
ajst-392	41	6	and	and	CCONJ
ajst-392	41	7	reverse	reverse	VERB
ajst-392	41	8	5ggttgtcaggggagtgttgatg-3	5ggttgtcaggggagtgttgatg-3	NUM
ajst-392	41	9	;	;	PUNCT
ajst-392	41	10	fizz1	fizz1	X
ajst-392	41	11	:	:	PUNCT
ajst-392	41	12	forward	forward	ADV
ajst-392	41	13	5cctgctgggatgactgcta-3	5cctgctgggatgactgcta-3	NUM
ajst-392	41	14	and	and	CCONJ
ajst-392	41	15	reverse	reverse	VERB
ajst-392	41	16	5tgggttctccacctcttcat-3	5tgggttctccacctcttcat-3	NUM
ajst-392	41	17	;	;	PUNCT
ajst-392	41	18	tnf	tnf	PROPN
ajst-392	41	19	-	-	PUNCT
ajst-392	41	20	α	α	NOUN
ajst-392	41	21	:	:	PUNCT
ajst-392	41	22	forward	forward	ADV
ajst-392	41	23	5aatggcctccctctcatcagtt-3	5aatggcctccctctcatcagtt-3	NUM
ajst-392	41	24	and	and	CCONJ
ajst-392	41	25	reverse	reverse	VERB
ajst-392	41	26	5ccacttggtggtttgctacga-3	5ccacttggtggtttgctacga-3	NUM
ajst-392	41	27	;	;	PUNCT
ajst-392	41	28	nos-2	nos-2	X
ajst-392	41	29	:	:	PUNCT
ajst-392	41	30	forward	forward	ADV
ajst-392	41	31	5aatcttggagcgagttgtgg-3	5aatcttggagcgagttgtgg-3	NUM
ajst-392	41	32	and	and	CCONJ
ajst-392	41	33	reverse	reverse	VERB
ajst-392	41	34	5	5	NUM
ajst-392	41	35	caggaagtaggtgagggcttg-3	caggaagtaggtgagggcttg-3	NOUN
ajst-392	41	36	;	;	PUNCT
ajst-392	41	37	β	β	X
ajst-392	41	38	-	-	PUNCT
ajst-392	41	39	actin	actin	NOUN
ajst-392	41	40	:	:	PUNCT
ajst-392	41	41	forward	forward	ADV
ajst-392	41	42	5	5	NUM
ajst-392	41	43	tgtccaccttccagcagatgt	tgtccaccttccagcagatgt	NOUN
ajst-392	41	44	and	and	CCONJ
ajst-392	41	45	reverse	reverse	VERB
ajst-392	41	46	5	5	NUM
ajst-392	41	47	agctcagtaacagtccgcctaga-3	agctcagtaacagtccgcctaga-3	NOUN
ajst-392	41	48	.	.	PUNCT
ajst-392	42	1	a	a	DET
ajst-392	42	2	real	real	ADJ
ajst-392	42	3	-	-	PUNCT
ajst-392	42	4	time	time	NOUN
ajst-392	42	5	pcr	pcr	ADJ
ajst-392	42	6	machine	machine	NOUN
ajst-392	42	7	was	be	AUX
ajst-392	42	8	used	use	VERB
ajst-392	42	9	and	and	CCONJ
ajst-392	42	10	data	datum	NOUN
ajst-392	42	11	were	be	AUX
ajst-392	42	12	normalized	normalize	VERB
ajst-392	42	13	with	with	ADP
ajst-392	42	14	β	β	NOUN
ajst-392	42	15	-	-	NOUN
ajst-392	42	16	actin	actin	NOUN
ajst-392	42	17	according	accord	VERB
ajst-392	42	18	to	to	ADP
ajst-392	42	19	the	the	DET
ajst-392	42	20	2	2	NUM
ajst-392	42	21	-	-	PUNCT
ajst-392	42	22	δδt	δδt	NOUN
ajst-392	42	23	method	method	NOUN
ajst-392	42	24	.	.	PUNCT
ajst-392	43	1	2.5	2.5	NUM
ajst-392	43	2	.	.	PUNCT
ajst-392	44	1	total	total	ADJ
ajst-392	44	2	protein	protein	NOUN
ajst-392	44	3	extraction	extraction	NOUN
ajst-392	44	4	and	and	CCONJ
ajst-392	44	5	western	western	ADJ
ajst-392	44	6	blot	blot	NOUN
ajst-392	44	7	2	2	NUM
ajst-392	44	8	×	×	NOUN
ajst-392	44	9	106	106	NUM
ajst-392	44	10	cells	cell	NOUN
ajst-392	44	11	were	be	AUX
ajst-392	44	12	lysed	lyse	VERB
ajst-392	44	13	in	in	ADP
ajst-392	44	14	ripa	ripa	ADJ
ajst-392	44	15	lysis	lysis	NOUN
ajst-392	44	16	buffer	buffer	NOUN
ajst-392	44	17	(	(	PUNCT
ajst-392	44	18	biyuntian	biyuntian	PROPN
ajst-392	44	19	,	,	PUNCT
ajst-392	44	20	shanghai	shanghai	PROPN
ajst-392	44	21	,	,	PUNCT
ajst-392	44	22	china	china	PROPN
ajst-392	44	23	)	)	PUNCT
ajst-392	44	24	containing	contain	VERB
ajst-392	44	25	protease	protease	NOUN
ajst-392	44	26	inhibitors	inhibitor	NOUN
ajst-392	44	27	and	and	CCONJ
ajst-392	44	28	phosphatase	phosphatase	ADJ
ajst-392	44	29	inhibitors	inhibitor	NOUN
ajst-392	44	30	.	.	PUNCT
ajst-392	45	1	proteins	protein	NOUN
ajst-392	45	2	were	be	AUX
ajst-392	45	3	separated	separate	VERB
ajst-392	45	4	on	on	ADP
ajst-392	45	5	12	12	NUM
ajst-392	45	6	%	%	NOUN
ajst-392	45	7	sdspage	sdspage	NOUN
ajst-392	45	8	gels	gel	NOUN
ajst-392	45	9	and	and	CCONJ
ajst-392	45	10	transferred	transfer	VERB
ajst-392	45	11	to	to	ADP
ajst-392	45	12	pvdf	pvdf	PROPN
ajst-392	45	13	membranes	membrane	NOUN
ajst-392	45	14	.	.	PUNCT
ajst-392	46	1	blocked	block	VERB
ajst-392	46	2	in	in	ADP
ajst-392	46	3	blocking	block	VERB
ajst-392	46	4	solution	solution	NOUN
ajst-392	46	5	containing	contain	VERB
ajst-392	46	6	5	5	NUM
ajst-392	46	7	%	%	NOUN
ajst-392	46	8	bovine	bovine	NOUN
ajst-392	46	9	serum	serum	NOUN
ajst-392	46	10	albumin	albumin	NOUN
ajst-392	46	11	and	and	CCONJ
ajst-392	46	12	1	1	NUM
ajst-392	46	13	%	%	NOUN
ajst-392	46	14	tween-20	tween-20	PROPN
ajst-392	46	15	for	for	ADP
ajst-392	46	16	2	2	NUM
ajst-392	46	17	h	h	NOUN
ajst-392	46	18	at	at	ADP
ajst-392	46	19	room	room	NOUN
ajst-392	46	20	temperature	temperature	NOUN
ajst-392	46	21	,	,	PUNCT
ajst-392	46	22	incubated	incubate	VERB
ajst-392	46	23	with	with	ADP
ajst-392	46	24	primary	primary	ADJ
ajst-392	46	25	antibody	antibody	NOUN
ajst-392	46	26	diluted	dilute	VERB
ajst-392	46	27	in	in	ADP
ajst-392	46	28	2	2	NUM
ajst-392	46	29	%	%	NOUN
ajst-392	46	30	tbst	tbst	NOUN
ajst-392	46	31	at	at	ADP
ajst-392	46	32	4	4	NUM
ajst-392	46	33	°	°	NOUN
ajst-392	46	34	c	c	NOUN
ajst-392	46	35	overnight	overnight	ADV
ajst-392	46	36	,	,	PUNCT
ajst-392	46	37	and	and	CCONJ
ajst-392	46	38	then	then	ADV
ajst-392	46	39	incubated	incubate	VERB
ajst-392	46	40	with	with	ADP
ajst-392	46	41	hrp	hrp	PROPN
ajst-392	46	42	-	-	PUNCT
ajst-392	46	43	conjugated	conjugate	VERB
ajst-392	46	44	secondary	secondary	ADJ
ajst-392	46	45	antibody	antibody	NOUN
ajst-392	46	46	for	for	ADP
ajst-392	46	47	1	1	NUM
ajst-392	46	48	h	h	NOUN
ajst-392	46	49	at	at	ADP
ajst-392	46	50	room	room	NOUN
ajst-392	46	51	temperature	temperature	NOUN
ajst-392	46	52	.	.	PUNCT
ajst-392	47	1	blots	blot	NOUN
ajst-392	47	2	were	be	AUX
ajst-392	47	3	visualized	visualize	VERB
ajst-392	47	4	by	by	ADP
ajst-392	47	5	ecl	ecl	PROPN
ajst-392	47	6	chemiluminescent	chemiluminescent	PROPN
ajst-392	47	7	solution	solution	NOUN
ajst-392	47	8	(	(	PUNCT
ajst-392	47	9	yeasen	yeasen	PROPN
ajst-392	47	10	,	,	PUNCT
ajst-392	47	11	shanghai	shanghai	PROPN
ajst-392	47	12	,	,	PUNCT
ajst-392	47	13	china	china	PROPN
ajst-392	47	14	)	)	PUNCT
ajst-392	47	15	.	.	PUNCT
ajst-392	48	1	blot	blot	NOUN
ajst-392	48	2	densities	density	NOUN
ajst-392	48	3	were	be	AUX
ajst-392	48	4	quantified	quantify	VERB
ajst-392	48	5	with	with	ADP
ajst-392	48	6	the	the	DET
ajst-392	48	7	software	software	NOUN
ajst-392	48	8	imagej	imagej	ADV
ajst-392	48	9	,	,	PUNCT
ajst-392	48	10	normalized	normalize	VERB
ajst-392	48	11	to	to	ADP
ajst-392	48	12	β	β	NOUN
ajst-392	48	13	-	-	NOUN
ajst-392	48	14	actin	actin	NOUN
ajst-392	48	15	.	.	PUNCT
ajst-392	49	1	the	the	DET
ajst-392	49	2	primary	primary	ADJ
ajst-392	49	3	antibodies	antibody	NOUN
ajst-392	49	4	used	use	VERB
ajst-392	49	5	in	in	ADP
ajst-392	49	6	this	this	DET
ajst-392	49	7	study	study	NOUN
ajst-392	49	8	include	include	VERB
ajst-392	49	9	:	:	PUNCT
ajst-392	49	10	anti	anti	ADJ
ajst-392	49	11	-	-	ADJ
ajst-392	49	12	il-6	il-6	ADJ
ajst-392	49	13	,	,	PUNCT
ajst-392	49	14	anti	anti	ADJ
ajst-392	49	15	-	-	ADJ
ajst-392	49	16	mcp-1	mcp-1	ADJ
ajst-392	49	17	,	,	PUNCT
ajst-392	49	18	anti	anti	ADJ
ajst-392	49	19	-	-	ADJ
ajst-392	49	20	il-1β	il-1β	ADJ
ajst-392	49	21	,	,	PUNCT
ajst-392	49	22	anti	anti	ADJ
ajst-392	49	23	-	-	ADJ
ajst-392	49	24	tnf	tnf	ADJ
ajst-392	49	25	-	-	PUNCT
ajst-392	49	26	α	α	PROPN
ajst-392	49	27	,	,	PUNCT
ajst-392	49	28	anti	anti	ADJ
ajst-392	49	29	-	-	ADJ
ajst-392	49	30	tlr4	tlr4	ADJ
ajst-392	49	31	,	,	PUNCT
ajst-392	49	32	anti	anti	ADJ
ajst-392	49	33	-	-	ADJ
ajst-392	49	34	ikk2	ikk2	ADJ
ajst-392	49	35	,	,	PUNCT
ajst-392	49	36	anti	anti	ADJ
ajst-392	49	37	-	-	ADJ
ajst-392	49	38	p	p	ADJ
ajst-392	49	39	-	-	PUNCT
ajst-392	49	40	ikk2	ikk2	PROPN
ajst-392	49	41	,	,	PUNCT
ajst-392	49	42	anti	anti	ADJ
ajst-392	49	43	-	-	ADJ
ajst-392	49	44	iκbα	iκbα	ADJ
ajst-392	49	45	,	,	PUNCT
ajst-392	49	46	anti	anti	ADJ
ajst-392	49	47	-	-	ADJ
ajst-392	49	48	p	p	ADJ
ajst-392	49	49	-	-	PUNCT
ajst-392	49	50	iκbα	iκbα	NOUN
ajst-392	49	51	,	,	PUNCT
ajst-392	49	52	anti	anti	ADJ
ajst-392	49	53	-	-	ADJ
ajst-392	49	54	p	p	ADJ
ajst-392	49	55	-	-	PUNCT
ajst-392	49	56	nf	nf	NOUN
ajst-392	49	57	-	-	PUNCT
ajst-392	49	58	κb	κb	NOUN
ajst-392	49	59	,	,	PUNCT
ajst-392	49	60	anti	anti	ADJ
ajst-392	49	61	-	-	ADJ
ajst-392	49	62	jnk	jnk	ADJ
ajst-392	49	63	,	,	PUNCT
ajst-392	49	64	anti	anti	ADJ
ajst-392	49	65	-	-	ADJ
ajst-392	49	66	p	p	ADJ
ajst-392	49	67	-	-	PUNCT
ajst-392	49	68	jnk	jnk	NOUN
ajst-392	49	69	,	,	PUNCT
ajst-392	49	70	anti	anti	ADJ
ajst-392	49	71	-	-	ADJ
ajst-392	49	72	p38	p38	ADJ
ajst-392	49	73	,	,	PUNCT
ajst-392	49	74	anti	anti	ADJ
ajst-392	49	75	-	-	ADJ
ajst-392	49	76	p	p	ADJ
ajst-392	49	77	-	-	PUNCT
ajst-392	49	78	p38	p38	NOUN
ajst-392	49	79	,	,	PUNCT
ajst-392	49	80	anti	anti	ADJ
ajst-392	49	81	-	-	ADJ
ajst-392	49	82	β	β	NOUN
ajst-392	49	83	-	-	PUNCT
ajst-392	49	84	actin	actin	NOUN
ajst-392	49	85	were	be	AUX
ajst-392	49	86	obtained	obtain	VERB
ajst-392	49	87	from	from	ADP
ajst-392	49	88	cst	cst	PROPN
ajst-392	49	89	and	and	CCONJ
ajst-392	49	90	santa	santa	PROPN
ajst-392	49	91	cruze	cruze	PROPN
ajst-392	49	92	.	.	PUNCT
ajst-392	50	1	2.6	2.6	NUM
ajst-392	50	2	.	.	PUNCT
ajst-392	51	1	statistics	statistic	NOUN
ajst-392	51	2	all	all	DET
ajst-392	51	3	data	datum	NOUN
ajst-392	51	4	were	be	AUX
ajst-392	51	5	statistically	statistically	ADV
ajst-392	51	6	analyzed	analyze	VERB
ajst-392	51	7	by	by	ADP
ajst-392	51	8	graphpad	graphpad	NOUN
ajst-392	51	9	prism	prism	NOUN
ajst-392	51	10	8	8	NUM
ajst-392	51	11	software	software	NOUN
ajst-392	51	12	,	,	PUNCT
ajst-392	51	13	and	and	CCONJ
ajst-392	51	14	the	the	DET
ajst-392	51	15	results	result	NOUN
ajst-392	51	16	are	be	AUX
ajst-392	51	17	expressed	express	VERB
ajst-392	51	18	as	as	ADP
ajst-392	51	19	mean	mean	PROPN
ajst-392	51	20	±	±	NUM
ajst-392	51	21	sem	sem	PROPN
ajst-392	51	22	.	.	PUNCT
ajst-392	52	1	data	datum	NOUN
ajst-392	52	2	analysis	analysis	NOUN
ajst-392	52	3	was	be	AUX
ajst-392	52	4	performed	perform	VERB
ajst-392	52	5	using	use	VERB
ajst-392	52	6	one	one	NUM
ajst-392	52	7	-	-	PUNCT
ajst-392	52	8	way	way	NOUN
ajst-392	52	9	anova	anova	PROPN
ajst-392	52	10	and	and	CCONJ
ajst-392	52	11	independent	independent	ADJ
ajst-392	52	12	samples	sample	NOUN
ajst-392	52	13	t	t	NOUN
ajst-392	52	14	-	-	PUNCT
ajst-392	52	15	test	test	NOUN
ajst-392	52	16	.	.	PUNCT
ajst-392	53	1	differences	difference	NOUN
ajst-392	53	2	were	be	AUX
ajst-392	53	3	considered	consider	VERB
ajst-392	53	4	statistically	statistically	ADV
ajst-392	53	5	significant	significant	ADJ
ajst-392	53	6	when	when	SCONJ
ajst-392	53	7	p<0.05	p<0.05	NOUN
ajst-392	53	8	.	.	PROPN
ajst-392	54	1	3	3	NUM
ajst-392	54	2	.	.	NOUN
ajst-392	54	3	results	result	NOUN
ajst-392	54	4	3.1	3.1	NUM
ajst-392	54	5	.	.	PUNCT
ajst-392	55	1	pacap	pacap	NOUN
ajst-392	55	2	does	do	AUX
ajst-392	55	3	not	not	PART
ajst-392	55	4	impair	impair	VERB
ajst-392	55	5	the	the	DET
ajst-392	55	6	viability	viability	NOUN
ajst-392	55	7	of	of	ADP
ajst-392	55	8	mouse	mouse	NOUN
ajst-392	55	9	raw264.7	raw264.7	NOUN
ajst-392	55	10	cells	cell	NOUN
ajst-392	55	11	pacap	pacap	VERB
ajst-392	55	12	is	be	AUX
ajst-392	55	13	a	a	DET
ajst-392	55	14	multifunctional	multifunctional	ADJ
ajst-392	55	15	neuropeptide	neuropeptide	NOUN
ajst-392	55	16	with	with	ADP
ajst-392	55	17	broad	broad	ADJ
ajst-392	55	18	antiinflammatory	antiinflammatory	NOUN
ajst-392	55	19	effects	effect	NOUN
ajst-392	55	20	.	.	PUNCT
ajst-392	56	1	firstly	firstly	ADV
ajst-392	56	2	,	,	PUNCT
ajst-392	56	3	the	the	DET
ajst-392	56	4	effect	effect	NOUN
ajst-392	56	5	of	of	ADP
ajst-392	56	6	different	different	ADJ
ajst-392	56	7	concentrations	concentration	NOUN
ajst-392	56	8	of	of	ADP
ajst-392	56	9	pacap	pacap	NOUN
ajst-392	56	10	on	on	ADP
ajst-392	56	11	the	the	DET
ajst-392	56	12	viability	viability	NOUN
ajst-392	56	13	of	of	ADP
ajst-392	56	14	raw264.7	raw264.7	PROPN
ajst-392	56	15	cells	cell	NOUN
ajst-392	56	16	was	be	AUX
ajst-392	56	17	detected	detect	VERB
ajst-392	56	18	by	by	ADP
ajst-392	56	19	cck-8	cck-8	PUNCT
ajst-392	56	20	method	method	NOUN
ajst-392	56	21	.	.	PUNCT
ajst-392	57	1	the	the	DET
ajst-392	57	2	results	result	NOUN
ajst-392	57	3	showed	show	VERB
ajst-392	57	4	that	that	SCONJ
ajst-392	57	5	at	at	ADP
ajst-392	57	6	the	the	DET
ajst-392	57	7	concentration	concentration	NOUN
ajst-392	57	8	of	of	ADP
ajst-392	57	9	0.01	0.01	NUM
ajst-392	57	10	μm	μm	NOUN
ajst-392	57	11	,	,	PUNCT
ajst-392	57	12	the	the	DET
ajst-392	57	13	cell	cell	NOUN
ajst-392	57	14	viability	viability	NOUN
ajst-392	57	15	was	be	AUX
ajst-392	57	16	117	117	NUM
ajst-392	57	17	%	%	NOUN
ajst-392	57	18	,	,	PUNCT
ajst-392	57	19	which	which	PRON
ajst-392	57	20	was	be	AUX
ajst-392	57	21	significantly	significantly	ADV
ajst-392	57	22	different	different	ADJ
ajst-392	57	23	from	from	ADP
ajst-392	57	24	the	the	DET
ajst-392	57	25	control	control	NOUN
ajst-392	57	26	group	group	NOUN
ajst-392	57	27	(	(	PUNCT
ajst-392	57	28	fig	fig	NOUN
ajst-392	57	29	.	.	NOUN
ajst-392	58	1	1	1	NUM
ajst-392	58	2	)	)	PUNCT
ajst-392	58	3	(	(	PUNCT
ajst-392	58	4	p<0.05	p<0.05	NOUN
ajst-392	58	5	)	)	PUNCT
ajst-392	58	6	.	.	PUNCT
ajst-392	59	1	with	with	ADP
ajst-392	59	2	the	the	DET
ajst-392	59	3	increase	increase	NOUN
ajst-392	59	4	of	of	ADP
ajst-392	59	5	pacap	pacap	NOUN
ajst-392	59	6	concentration	concentration	NOUN
ajst-392	59	7	,	,	PUNCT
ajst-392	59	8	the	the	DET
ajst-392	59	9	viability	viability	NOUN
ajst-392	59	10	of	of	ADP
ajst-392	59	11	macrophages	macrophage	NOUN
ajst-392	59	12	increased	increase	VERB
ajst-392	59	13	significantly	significantly	ADV
ajst-392	59	14	compared	compare	VERB
ajst-392	59	15	with	with	ADP
ajst-392	59	16	the	the	DET
ajst-392	59	17	normal	normal	ADJ
ajst-392	59	18	control	control	NOUN
ajst-392	59	19	group	group	NOUN
ajst-392	59	20	(	(	PUNCT
ajst-392	59	21	p<0.001	p<0.001	PROPN
ajst-392	59	22	)	)	PUNCT
ajst-392	59	23	,	,	PUNCT
ajst-392	59	24	suggesting	suggest	VERB
ajst-392	59	25	that	that	DET
ajst-392	59	26	pacap	pacap	NOUN
ajst-392	59	27	does	do	AUX
ajst-392	59	28	not	not	PART
ajst-392	59	29	produce	produce	VERB
ajst-392	59	30	cytotoxicity	cytotoxicity	NOUN
ajst-392	59	31	and	and	CCONJ
ajst-392	59	32	has	have	VERB
ajst-392	59	33	a	a	DET
ajst-392	59	34	significant	significant	ADJ
ajst-392	59	35	effect	effect	NOUN
ajst-392	59	36	on	on	ADP
ajst-392	59	37	promoting	promote	VERB
ajst-392	59	38	cell	cell	NOUN
ajst-392	59	39	proliferation	proliferation	NOUN
ajst-392	59	40	in	in	ADP
ajst-392	59	41	the	the	DET
ajst-392	59	42	concentration	concentration	NOUN
ajst-392	59	43	range	range	NOUN
ajst-392	59	44	of	of	ADP
ajst-392	59	45	0.01	0.01	NUM
ajst-392	59	46	-	-	SYM
ajst-392	59	47	10	10	NUM
ajst-392	59	48	μm	μm	NOUN
ajst-392	59	49	.	.	PUNCT
ajst-392	60	1	*	*	PUNCT
ajst-392	60	2	*	*	PUNCT
ajst-392	60	3	ns	ns	NUM
ajst-392	60	4	*	*	NOUN
ajst-392	60	5	*	*	PUNCT
ajst-392	60	6	*	*	PUNCT
ajst-392	60	7	*	*	PUNCT
ajst-392	60	8	*	*	PUNCT
ajst-392	60	9	*	*	PUNCT
ajst-392	60	10	*	*	PUNCT
ajst-392	60	11	*	*	PUNCT
ajst-392	60	12	*	*	PUNCT
ajst-392	60	13	figure	figure	NOUN
ajst-392	60	14	1	1	NUM
ajst-392	60	15	.	.	PUNCT
ajst-392	60	16	cytotoxicity	cytotoxicity	NOUN
ajst-392	60	17	of	of	ADP
ajst-392	60	18	different	different	ADJ
ajst-392	60	19	concentrations	concentration	NOUN
ajst-392	60	20	of	of	ADP
ajst-392	60	21	pacap	pacap	NOUN
ajst-392	60	22	on	on	ADP
ajst-392	60	23	raw264.7	raw264.7	NOUN
ajst-392	60	24	cells	cell	NOUN
ajst-392	60	25	.	.	PUNCT
ajst-392	61	1	raw264.7	raw264.7	NOUN
ajst-392	61	2	cells	cell	NOUN
ajst-392	61	3	were	be	AUX
ajst-392	61	4	treated	treat	VERB
ajst-392	61	5	with	with	ADP
ajst-392	61	6	0.001	0.001	NUM
ajst-392	61	7	-	-	SYM
ajst-392	61	8	10	10	NUM
ajst-392	61	9	μm	μm	NUM
ajst-392	61	10	pacap	pacap	NOUN
ajst-392	61	11	for	for	ADP
ajst-392	61	12	24	24	NUM
ajst-392	61	13	h	h	NOUN
ajst-392	61	14	,	,	PUNCT
ajst-392	61	15	and	and	CCONJ
ajst-392	61	16	cell	cell	NOUN
ajst-392	61	17	viability	viability	NOUN
ajst-392	61	18	was	be	AUX
ajst-392	61	19	determined	determine	VERB
ajst-392	61	20	by	by	ADP
ajst-392	61	21	cck-8	cck-8	PUNCT
ajst-392	61	22	method	method	NOUN
ajst-392	61	23	.	.	PUNCT
ajst-392	62	1	normal	normal	ADJ
ajst-392	62	2	control	control	NOUN
ajst-392	62	3	.	.	PUNCT
ajst-392	63	1	*	*	PUNCT
ajst-392	63	2	*	*	PUNCT
ajst-392	63	3	p<0.01	p<0.01	PROPN
ajst-392	63	4	,	,	PUNCT
ajst-392	63	5	*	*	PUNCT
ajst-392	63	6	*	*	PUNCT
ajst-392	63	7	*	*	PUNCT
ajst-392	63	8	p<0.001，nc	p<0.001，nc	NOUN
ajst-392	63	9	group	group	NOUN
ajst-392	63	10	vs	vs	ADP
ajst-392	63	11	different	different	ADJ
ajst-392	63	12	concentrations	concentration	NOUN
ajst-392	63	13	of	of	ADP
ajst-392	63	14	pacap	pacap	NOUN
ajst-392	63	15	treatment	treatment	NOUN
ajst-392	63	16	groups	group	NOUN
ajst-392	63	17	.	.	PUNCT
ajst-392	64	1	ns	n	VERB
ajst-392	64	2	,	,	PUNCT
ajst-392	64	3	no	no	DET
ajst-392	64	4	significant	significant	ADJ
ajst-392	64	5	difference	difference	NOUN
ajst-392	64	6	.	.	PUNCT
ajst-392	65	1	data	datum	NOUN
ajst-392	65	2	are	be	AUX
ajst-392	65	3	presented	present	VERB
ajst-392	65	4	as	as	ADP
ajst-392	65	5	mean	mean	PROPN
ajst-392	65	6	±	±	NUM
ajst-392	65	7	sem	sem	NOUN
ajst-392	65	8	.	.	PROPN
ajst-392	66	1	3.2	3.2	NUM
ajst-392	66	2	.	.	PUNCT
ajst-392	67	1	pacap	pacap	NOUN
ajst-392	67	2	does	do	AUX
ajst-392	67	3	not	not	PART
ajst-392	67	4	directly	directly	ADV
ajst-392	67	5	cause	cause	VERB
ajst-392	67	6	raw264.7	raw264.7	NOUN
ajst-392	67	7	macrophage	macrophage	ADJ
ajst-392	67	8	polarization	polarization	NOUN
ajst-392	67	9	in	in	ADP
ajst-392	67	10	order	order	NOUN
ajst-392	67	11	to	to	PART
ajst-392	67	12	explore	explore	VERB
ajst-392	67	13	whether	whether	SCONJ
ajst-392	67	14	pacap	pacap	NOUN
ajst-392	67	15	can	can	AUX
ajst-392	67	16	directly	directly	ADV
ajst-392	67	17	induce	induce	VERB
ajst-392	67	18	m1	m1	NOUN
ajst-392	67	19	or	or	CCONJ
ajst-392	67	20	m2	m2	PROPN
ajst-392	67	21	polarization	polarization	NOUN
ajst-392	67	22	of	of	ADP
ajst-392	67	23	raw264.7	raw264.7	NOUN
ajst-392	67	24	cells	cell	NOUN
ajst-392	67	25	,	,	PUNCT
ajst-392	67	26	after	after	ADP
ajst-392	67	27	adding	add	VERB
ajst-392	67	28	different	different	ADJ
ajst-392	67	29	concentrations	concentration	NOUN
ajst-392	67	30	of	of	ADP
ajst-392	67	31	pacap	pacap	NOUN
ajst-392	67	32	for	for	ADP
ajst-392	67	33	24	24	NUM
ajst-392	67	34	h	h	NOUN
ajst-392	67	35	,	,	PUNCT
ajst-392	67	36	the	the	DET
ajst-392	67	37	transcription	transcription	NOUN
ajst-392	67	38	levels	level	NOUN
ajst-392	67	39	of	of	ADP
ajst-392	67	40	m1	m1	PROPN
ajst-392	67	41	and	and	CCONJ
ajst-392	67	42	m2	m2	PROPN
ajst-392	67	43	marker	marker	NOUN
ajst-392	67	44	genes	gene	NOUN
ajst-392	67	45	in	in	ADP
ajst-392	67	46	macrophages	macrophage	NOUN
ajst-392	67	47	were	be	AUX
ajst-392	67	48	detected	detect	VERB
ajst-392	67	49	by	by	ADP
ajst-392	67	50	rt	rt	NOUN
ajst-392	67	51	-	-	PUNCT
ajst-392	67	52	qpcr	qpcr	ADV
ajst-392	67	53	(	(	PUNCT
ajst-392	67	54	fig	fig	NOUN
ajst-392	67	55	.	.	PUNCT
ajst-392	68	1	2a	2a	NUM
ajst-392	68	2	)	)	PUNCT
ajst-392	68	3	.	.	PUNCT
ajst-392	69	1	the	the	DET
ajst-392	69	2	effect	effect	NOUN
ajst-392	69	3	of	of	ADP
ajst-392	69	4	pacap	pacap	NOUN
ajst-392	69	5	on	on	ADP
ajst-392	69	6	the	the	DET
ajst-392	69	7	expression	expression	NOUN
ajst-392	69	8	of	of	ADP
ajst-392	69	9	inflammatory	inflammatory	ADJ
ajst-392	69	10	factors	factor	NOUN
ajst-392	69	11	was	be	AUX
ajst-392	69	12	detected	detect	VERB
ajst-392	69	13	by	by	ADP
ajst-392	69	14	western	western	ADJ
ajst-392	69	15	blot	blot	NOUN
ajst-392	69	16	(	(	PUNCT
ajst-392	69	17	fig	fig	NOUN
ajst-392	69	18	.	.	PUNCT
ajst-392	70	1	2b	2b	NUM
ajst-392	70	2	)	)	PUNCT
ajst-392	70	3	and	and	CCONJ
ajst-392	70	4	no	no	DET
ajst-392	70	5	content	content	NOUN
ajst-392	70	6	in	in	ADP
ajst-392	70	7	cell	cell	NOUN
ajst-392	70	8	culture	culture	NOUN
ajst-392	70	9	medium	medium	NOUN
ajst-392	70	10	(	(	PUNCT
ajst-392	70	11	fig	fig	NOUN
ajst-392	70	12	.	.	PUNCT
ajst-392	71	1	2c	2c	NUM
ajst-392	71	2	)	)	PUNCT
ajst-392	71	3	.	.	PUNCT
ajst-392	72	1	the	the	DET
ajst-392	72	2	results	result	NOUN
ajst-392	72	3	showed	show	VERB
ajst-392	72	4	that	that	SCONJ
ajst-392	72	5	compared	compare	VERB
ajst-392	72	6	with	with	ADP
ajst-392	72	7	the	the	DET
ajst-392	72	8	control	control	NOUN
ajst-392	72	9	group	group	NOUN
ajst-392	72	10	,	,	PUNCT
ajst-392	72	11	there	there	PRON
ajst-392	72	12	were	be	VERB
ajst-392	72	13	no	no	DET
ajst-392	72	14	significant	significant	ADJ
ajst-392	72	15	differences	difference	NOUN
ajst-392	72	16	in	in	ADP
ajst-392	72	17	the	the	DET
ajst-392	72	18	transcription	transcription	NOUN
ajst-392	72	19	levels	level	NOUN
ajst-392	72	20	of	of	ADP
ajst-392	72	21	13	13	NUM
ajst-392	72	22	m1	m1	NOUN
ajst-392	72	23	and	and	CCONJ
ajst-392	72	24	m2	m2	PROPN
ajst-392	72	25	marker	marker	NOUN
ajst-392	72	26	genes	gene	NOUN
ajst-392	72	27	,	,	PUNCT
ajst-392	72	28	the	the	DET
ajst-392	72	29	expression	expression	NOUN
ajst-392	72	30	of	of	ADP
ajst-392	72	31	inflammatory	inflammatory	ADJ
ajst-392	72	32	factors	factor	NOUN
ajst-392	72	33	and	and	CCONJ
ajst-392	72	34	the	the	DET
ajst-392	72	35	no	no	DET
ajst-392	72	36	content	content	NOUN
ajst-392	72	37	in	in	ADP
ajst-392	72	38	the	the	DET
ajst-392	72	39	cell	cell	NOUN
ajst-392	72	40	culture	culture	NOUN
ajst-392	72	41	medium	medium	NOUN
ajst-392	72	42	of	of	ADP
ajst-392	72	43	macrophages	macrophage	NOUN
ajst-392	72	44	treated	treat	VERB
ajst-392	72	45	with	with	ADP
ajst-392	72	46	different	different	ADJ
ajst-392	72	47	concentrations	concentration	NOUN
ajst-392	72	48	of	of	ADP
ajst-392	72	49	pacap	pacap	NOUN
ajst-392	72	50	.	.	PUNCT
ajst-392	73	1	it	it	PRON
ajst-392	73	2	indicated	indicate	VERB
ajst-392	73	3	that	that	SCONJ
ajst-392	73	4	the	the	DET
ajst-392	73	5	m1	m1	PROPN
ajst-392	73	6	or	or	CCONJ
ajst-392	73	7	m2	m2	PROPN
ajst-392	73	8	polarization	polarization	NOUN
ajst-392	73	9	did	do	AUX
ajst-392	73	10	not	not	PART
ajst-392	73	11	occur	occur	VERB
ajst-392	73	12	after	after	SCONJ
ajst-392	73	13	pacap	pacap	NOUN
ajst-392	73	14	directly	directly	ADV
ajst-392	73	15	acted	act	VERB
ajst-392	73	16	on	on	ADP
ajst-392	73	17	raw264.7	raw264.7	PROPN
ajst-392	73	18	cells	cell	NOUN
ajst-392	73	19	.	.	PUNCT
ajst-392	74	1	figure	figure	NOUN
ajst-392	74	2	2	2	NUM
ajst-392	74	3	.	.	PUNCT
ajst-392	74	4	pacap	pacap	NOUN
ajst-392	74	5	does	do	AUX
ajst-392	74	6	not	not	PART
ajst-392	74	7	directly	directly	ADV
ajst-392	74	8	cause	cause	VERB
ajst-392	74	9	raw264.7	raw264.7	NOUN
ajst-392	74	10	macrophage	macrophage	ADJ
ajst-392	74	11	polarization	polarization	NOUN
ajst-392	74	12	.	.	PUNCT
ajst-392	75	1	raw264.7	raw264.7	NOUN
ajst-392	75	2	cells	cell	NOUN
ajst-392	75	3	were	be	AUX
ajst-392	75	4	directly	directly	ADV
ajst-392	75	5	incubated	incubate	VERB
ajst-392	75	6	with	with	ADP
ajst-392	75	7	0.001	0.001	NUM
ajst-392	75	8	-	-	PUNCT
ajst-392	75	9	10μm	10μm	NUM
ajst-392	75	10	pacap	pacap	NOUN
ajst-392	75	11	for	for	ADP
ajst-392	75	12	24h	24h	NOUN
ajst-392	75	13	and	and	CCONJ
ajst-392	75	14	(	(	PUNCT
ajst-392	75	15	a	a	X
ajst-392	75	16	)	)	PUNCT
ajst-392	75	17	m1	m1	PROPN
ajst-392	75	18	and	and	CCONJ
ajst-392	75	19	m2	m2	PROPN
ajst-392	75	20	marker	marker	NOUN
ajst-392	75	21	gene	gene	NOUN
ajst-392	75	22	transcription	transcription	NOUN
ajst-392	75	23	levels	level	NOUN
ajst-392	75	24	were	be	AUX
ajst-392	75	25	detected	detect	VERB
ajst-392	75	26	by	by	ADP
ajst-392	75	27	rt	rt	PROPN
ajst-392	75	28	-	-	PUNCT
ajst-392	75	29	qpcr.(b	qpcr.(b	NOUN
ajst-392	75	30	)	)	PUNCT
ajst-392	75	31	the	the	DET
ajst-392	75	32	expression	expression	NOUN
ajst-392	75	33	of	of	ADP
ajst-392	75	34	inflammatory	inflammatory	ADJ
ajst-392	75	35	factors	factor	NOUN
ajst-392	75	36	were	be	AUX
ajst-392	75	37	detected	detect	VERB
ajst-392	75	38	by	by	ADP
ajst-392	75	39	western	western	ADJ
ajst-392	75	40	blot.(c	blot.(c	NOUN
ajst-392	75	41	)	)	PUNCT
ajst-392	76	1	no	no	DET
ajst-392	76	2	content	content	NOUN
ajst-392	76	3	in	in	ADP
ajst-392	76	4	cell	cell	NOUN
ajst-392	76	5	culture	culture	NOUN
ajst-392	76	6	medium	medium	NOUN
ajst-392	76	7	was	be	AUX
ajst-392	76	8	detected	detect	VERB
ajst-392	76	9	.	.	PUNCT
ajst-392	77	1	nc	nc	PROPN
ajst-392	77	2	group	group	PROPN
ajst-392	77	3	vs	vs	ADP
ajst-392	77	4	different	different	ADJ
ajst-392	77	5	concentrations	concentration	NOUN
ajst-392	77	6	of	of	ADP
ajst-392	77	7	pacap	pacap	NOUN
ajst-392	77	8	treatment	treatment	NOUN
ajst-392	77	9	groups	group	NOUN
ajst-392	77	10	.	.	PUNCT
ajst-392	78	1	data	datum	NOUN
ajst-392	78	2	are	be	AUX
ajst-392	78	3	presented	present	VERB
ajst-392	78	4	as	as	ADP
ajst-392	78	5	mean	mean	PROPN
ajst-392	78	6	±	±	NUM
ajst-392	78	7	sem	sem	NOUN
ajst-392	78	8	.	.	PROPN
ajst-392	79	1	3.3	3.3	NUM
ajst-392	79	2	.	.	PUNCT
ajst-392	80	1	pacap	pacap	PROPN
ajst-392	80	2	improves	improve	VERB
ajst-392	80	3	lps	lps	PROPN
ajst-392	80	4	-	-	PUNCT
ajst-392	80	5	induced	induce	VERB
ajst-392	80	6	m1	m1	NOUN
ajst-392	80	7	polarization	polarization	NOUN
ajst-392	80	8	and	and	CCONJ
ajst-392	80	9	inflammatory	inflammatory	ADJ
ajst-392	80	10	mediator	mediator	NOUN
ajst-392	80	11	expression	expression	NOUN
ajst-392	80	12	in	in	ADP
ajst-392	80	13	raw264.7	raw264.7	PROPN
ajst-392	80	14	cells	cell	NOUN
ajst-392	80	15	to	to	PART
ajst-392	80	16	explore	explore	VERB
ajst-392	80	17	the	the	DET
ajst-392	80	18	effect	effect	NOUN
ajst-392	80	19	of	of	ADP
ajst-392	80	20	pacap	pacap	NOUN
ajst-392	80	21	on	on	ADP
ajst-392	80	22	macrophage	macrophage	ADJ
ajst-392	80	23	m1	m1	PROPN
ajst-392	80	24	polarization	polarization	NOUN
ajst-392	80	25	,	,	PUNCT
ajst-392	80	26	lps	lps	PROPN
ajst-392	80	27	was	be	AUX
ajst-392	80	28	used	use	VERB
ajst-392	80	29	to	to	PART
ajst-392	80	30	construct	construct	VERB
ajst-392	80	31	a	a	DET
ajst-392	80	32	model	model	NOUN
ajst-392	80	33	of	of	ADP
ajst-392	80	34	macrophage	macrophage	ADJ
ajst-392	80	35	m1	m1	NOUN
ajst-392	80	36	polarization	polarization	NOUN
ajst-392	80	37	and	and	CCONJ
ajst-392	80	38	inflammation	inflammation	NOUN
ajst-392	80	39	.	.	PUNCT
ajst-392	81	1	the	the	DET
ajst-392	81	2	effects	effect	NOUN
ajst-392	81	3	of	of	ADP
ajst-392	81	4	0.001	0.001	NUM
ajst-392	81	5	-	-	SYM
ajst-392	81	6	10	10	NUM
ajst-392	81	7	μm	μm	NUM
ajst-392	81	8	pacap	pacap	NOUN
ajst-392	81	9	on	on	ADP
ajst-392	81	10	the	the	DET
ajst-392	81	11	transcription	transcription	NOUN
ajst-392	81	12	of	of	ADP
ajst-392	81	13	m1	m1	PROPN
ajst-392	81	14	polarization	polarization	NOUN
ajst-392	81	15	marker	marker	NOUN
ajst-392	81	16	genes	gene	NOUN
ajst-392	81	17	tnf	tnf	PROPN
ajst-392	81	18	-	-	PUNCT
ajst-392	81	19	α	α	PROPN
ajst-392	81	20	and	and	CCONJ
ajst-392	81	21	nos-2	nos-2	PUNCT
ajst-392	81	22	in	in	ADP
ajst-392	81	23	raw264.7	raw264.7	PROPN
ajst-392	81	24	cells	cell	NOUN
ajst-392	81	25	were	be	AUX
ajst-392	81	26	detected	detect	VERB
ajst-392	81	27	by	by	ADP
ajst-392	81	28	rt	rt	NOUN
ajst-392	81	29	-	-	PUNCT
ajst-392	81	30	qpcr	qpcr	ADV
ajst-392	81	31	(	(	PUNCT
ajst-392	81	32	figure	figure	NOUN
ajst-392	81	33	3a	3a	NUM
ajst-392	81	34	)	)	PUNCT
ajst-392	81	35	,	,	PUNCT
ajst-392	81	36	and	and	CCONJ
ajst-392	81	37	western	western	ADJ
ajst-392	81	38	blot	blot	NOUN
ajst-392	81	39	was	be	AUX
ajst-392	81	40	used	use	VERB
ajst-392	81	41	to	to	PART
ajst-392	81	42	detect	detect	VERB
ajst-392	81	43	the	the	DET
ajst-392	81	44	expression	expression	NOUN
ajst-392	81	45	levels	level	NOUN
ajst-392	81	46	of	of	ADP
ajst-392	81	47	intracellular	intracellular	ADJ
ajst-392	81	48	inflammatory	inflammatory	ADJ
ajst-392	81	49	factors	factor	NOUN
ajst-392	81	50	such	such	ADJ
ajst-392	81	51	as	as	ADP
ajst-392	81	52	tnf	tnf	PROPN
ajst-392	81	53	-	-	PUNCT
ajst-392	81	54	α	α	PROPN
ajst-392	81	55	,	,	PUNCT
ajst-392	81	56	il-6	il-6	NOUN
ajst-392	81	57	,	,	PUNCT
ajst-392	81	58	and	and	CCONJ
ajst-392	81	59	mcp-1	mcp-1	X
ajst-392	81	60	(	(	PUNCT
ajst-392	81	61	fig	fig	NOUN
ajst-392	81	62	.	.	PUNCT
ajst-392	82	1	3b	3b	NUM
ajst-392	82	2	)	)	PUNCT
ajst-392	82	3	and	and	CCONJ
ajst-392	82	4	no	no	DET
ajst-392	82	5	content	content	NOUN
ajst-392	82	6	in	in	ADP
ajst-392	82	7	cell	cell	NOUN
ajst-392	82	8	cultures	culture	NOUN
ajst-392	82	9	(	(	PUNCT
ajst-392	82	10	fig	fig	NOUN
ajst-392	82	11	.	.	PUNCT
ajst-392	83	1	3c	3c	NUM
ajst-392	83	2	)	)	PUNCT
ajst-392	83	3	.	.	PUNCT
ajst-392	84	1	the	the	DET
ajst-392	84	2	results	result	NOUN
ajst-392	84	3	showed	show	VERB
ajst-392	84	4	that	that	SCONJ
ajst-392	84	5	,	,	PUNCT
ajst-392	84	6	at	at	ADP
ajst-392	84	7	the	the	DET
ajst-392	84	8	concentration	concentration	NOUN
ajst-392	84	9	of	of	ADP
ajst-392	84	10	0.1	0.1	NUM
ajst-392	84	11	μm	μm	NOUN
ajst-392	84	12	,	,	PUNCT
ajst-392	84	13	the	the	DET
ajst-392	84	14	inhibitory	inhibitory	ADJ
ajst-392	84	15	effect	effect	NOUN
ajst-392	84	16	of	of	ADP
ajst-392	84	17	pacap	pacap	NOUN
ajst-392	84	18	on	on	ADP
ajst-392	84	19	m1	m1	NOUN
ajst-392	84	20	marker	marker	NOUN
ajst-392	84	21	gene	gene	NOUN
ajst-392	84	22	and	and	CCONJ
ajst-392	84	23	inflammatory	inflammatory	ADJ
ajst-392	84	24	mediators	mediator	NOUN
ajst-392	84	25	such	such	ADJ
ajst-392	84	26	as	as	ADP
ajst-392	84	27	tnf	tnf	PROPN
ajst-392	84	28	-	-	PUNCT
ajst-392	84	29	α	α	PROPN
ajst-392	84	30	,	,	PUNCT
ajst-392	84	31	il-6	il-6	NOUN
ajst-392	84	32	,	,	PUNCT
ajst-392	84	33	mcp-1	mcp-1	NOUN
ajst-392	84	34	,	,	PUNCT
ajst-392	84	35	and	and	CCONJ
ajst-392	84	36	no	no	PRON
ajst-392	84	37	was	be	AUX
ajst-392	84	38	significantly	significantly	ADV
ajst-392	84	39	different	different	ADJ
ajst-392	84	40	from	from	ADP
ajst-392	84	41	that	that	PRON
ajst-392	84	42	of	of	ADP
ajst-392	84	43	the	the	DET
ajst-392	84	44	modeling	modeling	NOUN
ajst-392	84	45	group	group	NOUN
ajst-392	84	46	,	,	PUNCT
ajst-392	84	47	and	and	CCONJ
ajst-392	84	48	there	there	PRON
ajst-392	84	49	were	be	VERB
ajst-392	84	50	no	no	DET
ajst-392	84	51	significant	significant	ADJ
ajst-392	84	52	differences	difference	NOUN
ajst-392	84	53	between	between	ADP
ajst-392	84	54	0.1	0.1	NUM
ajst-392	84	55	μm	μm	NUM
ajst-392	84	56	pacap	pacap	NOUN
ajst-392	84	57	treatment	treatment	NOUN
ajst-392	84	58	group	group	NOUN
ajst-392	84	59	and	and	CCONJ
ajst-392	84	60	1	1	NUM
ajst-392	84	61	μm	μm	NUM
ajst-392	84	62	pacap	pacap	NOUN
ajst-392	84	63	treatment	treatment	NOUN
ajst-392	84	64	group	group	NOUN
ajst-392	84	65	.	.	PUNCT
ajst-392	85	1	therefore	therefore	ADV
ajst-392	85	2	0.1	0.1	NUM
ajst-392	85	3	μm	μm	NOUN
ajst-392	85	4	was	be	AUX
ajst-392	85	5	chosen	choose	VERB
ajst-392	85	6	as	as	ADP
ajst-392	85	7	the	the	DET
ajst-392	85	8	pacap	pacap	NOUN
ajst-392	85	9	concentration	concentration	NOUN
ajst-392	85	10	for	for	ADP
ajst-392	85	11	subsequent	subsequent	ADJ
ajst-392	85	12	experiments	experiment	NOUN
ajst-392	85	13	.	.	PUNCT
ajst-392	86	1	3.4	3.4	NUM
ajst-392	86	2	.	.	PUNCT
ajst-392	86	3	pacap	pacap	PROPN
ajst-392	86	4	inhibits	inhibit	VERB
ajst-392	86	5	macrophage	macrophage	ADJ
ajst-392	86	6	m1	m1	NOUN
ajst-392	86	7	polarization	polarization	NOUN
ajst-392	86	8	and	and	CCONJ
ajst-392	86	9	inflammatory	inflammatory	ADJ
ajst-392	86	10	response	response	NOUN
ajst-392	86	11	by	by	ADP
ajst-392	86	12	specifically	specifically	ADV
ajst-392	86	13	activating	activate	VERB
ajst-392	86	14	pac1	pac1	NOUN
ajst-392	86	15	receptors	receptor	NOUN
ajst-392	86	16	pacap	pacap	NOUN
ajst-392	86	17	has	have	VERB
ajst-392	86	18	three	three	NUM
ajst-392	86	19	receptors	receptor	NOUN
ajst-392	86	20	,	,	PUNCT
ajst-392	86	21	pac1	pac1	NOUN
ajst-392	86	22	,	,	PUNCT
ajst-392	86	23	vpac1	vpac1	NOUN
ajst-392	86	24	and	and	CCONJ
ajst-392	86	25	vpac2	vpac2	PROPN
ajst-392	86	26	.	.	PUNCT
ajst-392	87	1	the	the	DET
ajst-392	87	2	type	type	NOUN
ajst-392	87	3	of	of	ADP
ajst-392	87	4	receptors	receptor	NOUN
ajst-392	87	5	in	in	ADP
ajst-392	87	6	which	which	PRON
ajst-392	87	7	pacap	pacap	NOUN
ajst-392	87	8	exerts	exert	VERB
ajst-392	87	9	its	its	PRON
ajst-392	87	10	antiinflammatory	antiinflammatory	NOUN
ajst-392	87	11	effect	effect	NOUN
ajst-392	87	12	is	be	AUX
ajst-392	87	13	determined	determine	VERB
ajst-392	87	14	by	by	ADP
ajst-392	87	15	using	use	VERB
ajst-392	87	16	receptor	receptor	NOUN
ajst-392	87	17	-	-	PUNCT
ajst-392	87	18	specific	specific	ADJ
ajst-392	87	19	inhibitors	inhibitor	NOUN
ajst-392	87	20	.	.	PUNCT
ajst-392	88	1	after	after	ADP
ajst-392	88	2	lps	lps	PROPN
ajst-392	88	3	stimulation	stimulation	NOUN
ajst-392	88	4	of	of	ADP
ajst-392	88	5	cells	cell	NOUN
ajst-392	88	6	,	,	PUNCT
ajst-392	88	7	1	1	NUM
ajst-392	88	8	μm	μm	NOUN
ajst-392	88	9	pg97	pg97	PROPN
ajst-392	88	10	-	-	PUNCT
ajst-392	88	11	269	269	NUM
ajst-392	88	12	,	,	PUNCT
ajst-392	88	13	1	1	NUM
ajst-392	88	14	μm	μm	NOUN
ajst-392	88	15	pg99	pg99	PROPN
ajst-392	88	16	-	-	PUNCT
ajst-392	88	17	465	465	NUM
ajst-392	88	18	,	,	PUNCT
ajst-392	88	19	and	and	CCONJ
ajst-392	88	20	1	1	NUM
ajst-392	88	21	μm	μm	NUM
ajst-392	88	22	max.d4	max.d4	NOUN
ajst-392	88	23	were	be	AUX
ajst-392	88	24	added	add	VERB
ajst-392	88	25	to	to	ADP
ajst-392	88	26	raw264.7	raw264.7	VERB
ajst-392	88	27	cells	cell	NOUN
ajst-392	88	28	for	for	ADP
ajst-392	88	29	pre	pre	NOUN
ajst-392	88	30	-	-	NOUN
ajst-392	88	31	incubation	incubation	NOUN
ajst-392	88	32	for	for	ADP
ajst-392	88	33	30	30	NUM
ajst-392	88	34	min	min	NOUN
ajst-392	88	35	,	,	PUNCT
ajst-392	88	36	and	and	CCONJ
ajst-392	88	37	then	then	ADV
ajst-392	88	38	0.1	0.1	NUM
ajst-392	88	39	μm	μm	NOUN
ajst-392	88	40	pacap	pacap	NOUN
ajst-392	88	41	was	be	AUX
ajst-392	88	42	added	add	VERB
ajst-392	88	43	to	to	PART
ajst-392	88	44	continue	continue	VERB
ajst-392	88	45	the	the	DET
ajst-392	88	46	culture	culture	NOUN
ajst-392	88	47	for	for	ADP
ajst-392	88	48	24	24	NUM
ajst-392	88	49	h	h	NOUN
ajst-392	88	50	,	,	PUNCT
ajst-392	88	51	the	the	DET
ajst-392	88	52	transcription	transcription	NOUN
ajst-392	88	53	levels	level	NOUN
ajst-392	88	54	of	of	ADP
ajst-392	88	55	m1	m1	PROPN
ajst-392	88	56	polarization	polarization	NOUN
ajst-392	88	57	marker	marker	NOUN
ajst-392	88	58	genes	gene	NOUN
ajst-392	88	59	tnf	tnf	PROPN
ajst-392	88	60	-	-	PUNCT
ajst-392	88	61	α	α	PROPN
ajst-392	88	62	and	and	CCONJ
ajst-392	88	63	nos-2	nos-2	PUNCT
ajst-392	88	64	in	in	ADP
ajst-392	88	65	raw264.7	raw264.7	PROPN
ajst-392	88	66	cells	cell	NOUN
ajst-392	88	67	were	be	AUX
ajst-392	88	68	detected	detect	VERB
ajst-392	88	69	by	by	ADP
ajst-392	88	70	rt	rt	NOUN
ajst-392	88	71	-	-	PUNCT
ajst-392	88	72	qpcr	qpcr	ADV
ajst-392	88	73	(	(	PUNCT
ajst-392	88	74	fig	fig	NOUN
ajst-392	88	75	4a),and	4a),and	PROPN
ajst-392	88	76	western	western	ADJ
ajst-392	88	77	blot	blot	NOUN
ajst-392	88	78	was	be	AUX
ajst-392	88	79	used	use	VERB
ajst-392	88	80	to	to	PART
ajst-392	88	81	detect	detect	VERB
ajst-392	88	82	the	the	DET
ajst-392	88	83	expression	expression	NOUN
ajst-392	88	84	levels	level	NOUN
ajst-392	88	85	of	of	ADP
ajst-392	88	86	intracellular	intracellular	ADJ
ajst-392	88	87	inflammatory	inflammatory	ADJ
ajst-392	88	88	factors	factor	NOUN
ajst-392	88	89	such	such	ADJ
ajst-392	88	90	as	as	ADP
ajst-392	88	91	tnf	tnf	PROPN
ajst-392	88	92	-	-	PUNCT
ajst-392	88	93	α	α	PROPN
ajst-392	88	94	,	,	PUNCT
ajst-392	88	95	il-6	il-6	NOUN
ajst-392	88	96	,	,	PUNCT
ajst-392	88	97	mcp-1	mcp-1	NOUN
ajst-392	88	98	,	,	PUNCT
ajst-392	88	99	and	and	CCONJ
ajst-392	88	100	il-1β(figure	il-1β(figure	PROPN
ajst-392	88	101	4b	4b	PROPN
ajst-392	88	102	)	)	PUNCT
ajst-392	88	103	.	.	PUNCT
ajst-392	89	1	the	the	DET
ajst-392	89	2	results	result	NOUN
ajst-392	89	3	showed	show	VERB
ajst-392	89	4	that	that	SCONJ
ajst-392	89	5	pacap	pacap	NOUN
ajst-392	89	6	could	could	AUX
ajst-392	89	7	not	not	PART
ajst-392	89	8	inhibit	inhibit	VERB
ajst-392	89	9	the	the	DET
ajst-392	89	10	m1	m1	PROPN
ajst-392	89	11	polarization	polarization	NOUN
ajst-392	89	12	and	and	CCONJ
ajst-392	89	13	inflammatory	inflammatory	ADJ
ajst-392	89	14	response	response	NOUN
ajst-392	89	15	in	in	ADP
ajst-392	89	16	raw264.7	raw264.7	PROPN
ajst-392	89	17	cells	cell	NOUN
ajst-392	89	18	after	after	ADP
ajst-392	89	19	adding	add	VERB
ajst-392	89	20	pac1	pac1	NOUN
ajst-392	89	21	receptor	receptor	NOUN
ajst-392	89	22	specific	specific	ADJ
ajst-392	89	23	inhibitor	inhibitor	NOUN
ajst-392	89	24	max.d4	max.d4	NOUN
ajst-392	89	25	,	,	PUNCT
ajst-392	89	26	indicating	indicate	VERB
ajst-392	89	27	that	that	SCONJ
ajst-392	89	28	pacap	pacap	NOUN
ajst-392	89	29	exerts	exert	VERB
ajst-392	89	30	anti	anti	ADJ
ajst-392	89	31	-	-	ADJ
ajst-392	89	32	inflammatory	inflammatory	ADJ
ajst-392	89	33	effect	effect	NOUN
ajst-392	89	34	through	through	ADP
ajst-392	89	35	pac1	pac1	NOUN
ajst-392	89	36	receptor	receptor	NOUN
ajst-392	89	37	in	in	ADP
ajst-392	89	38	raw264.7	raw264.7	PROPN
ajst-392	89	39	cells	cell	NOUN
ajst-392	89	40	.	.	PUNCT
ajst-392	90	1	14	14	NUM
ajst-392	90	2	figure	figure	NOUN
ajst-392	90	3	3	3	NUM
ajst-392	90	4	.	.	NOUN
ajst-392	90	5	pacap	pacap	PROPN
ajst-392	90	6	inhibited	inhibit	VERB
ajst-392	90	7	lps	lps	PROPN
ajst-392	90	8	-	-	PUNCT
ajst-392	90	9	induced	induce	VERB
ajst-392	90	10	m1	m1	NOUN
ajst-392	90	11	polarization	polarization	NOUN
ajst-392	90	12	and	and	CCONJ
ajst-392	90	13	inflammatory	inflammatory	ADJ
ajst-392	90	14	mediator	mediator	NOUN
ajst-392	90	15	expression	expression	NOUN
ajst-392	90	16	in	in	ADP
ajst-392	90	17	raw264.7	raw264.7	NOUN
ajst-392	90	18	cells	cell	NOUN
ajst-392	90	19	.	.	PUNCT
ajst-392	91	1	after	after	SCONJ
ajst-392	91	2	lps	lps	PROPN
ajst-392	91	3	stimulation	stimulation	VERB
ajst-392	91	4	12	12	NUM
ajst-392	91	5	h	h	NOUN
ajst-392	91	6	,	,	PUNCT
ajst-392	91	7	0.001	0.001	NUM
ajst-392	91	8	-	-	PUNCT
ajst-392	91	9	10μm	10μm	NUM
ajst-392	91	10	pacap	pacap	NOUN
ajst-392	91	11	was	be	AUX
ajst-392	91	12	treated	treat	VERB
ajst-392	91	13	for	for	ADP
ajst-392	91	14	24h	24h	NOUN
ajst-392	91	15	,	,	PUNCT
ajst-392	91	16	(	(	PUNCT
ajst-392	91	17	a	a	X
ajst-392	91	18	)	)	PUNCT
ajst-392	91	19	m1	m1	PROPN
ajst-392	91	20	and	and	CCONJ
ajst-392	91	21	m2	m2	PROPN
ajst-392	91	22	marker	marker	NOUN
ajst-392	91	23	gene	gene	NOUN
ajst-392	91	24	transcription	transcription	NOUN
ajst-392	91	25	levels	level	NOUN
ajst-392	91	26	were	be	AUX
ajst-392	91	27	detected	detect	VERB
ajst-392	91	28	by	by	ADP
ajst-392	91	29	rt	rt	PROPN
ajst-392	91	30	-	-	PUNCT
ajst-392	91	31	qpcr.(b	qpcr.(b	NOUN
ajst-392	91	32	)	)	PUNCT
ajst-392	91	33	the	the	DET
ajst-392	91	34	expression	expression	NOUN
ajst-392	91	35	of	of	ADP
ajst-392	91	36	inflammatory	inflammatory	ADJ
ajst-392	91	37	factors	factor	NOUN
ajst-392	91	38	were	be	AUX
ajst-392	91	39	detected	detect	VERB
ajst-392	91	40	by	by	ADP
ajst-392	91	41	western	western	ADJ
ajst-392	91	42	blot.(c	blot.(c	NOUN
ajst-392	91	43	)	)	PUNCT
ajst-392	92	1	no	no	DET
ajst-392	92	2	content	content	NOUN
ajst-392	92	3	in	in	ADP
ajst-392	92	4	cell	cell	NOUN
ajst-392	92	5	culture	culture	NOUN
ajst-392	92	6	medium	medium	NOUN
ajst-392	92	7	was	be	AUX
ajst-392	92	8	detected	detect	VERB
ajst-392	92	9	.	.	PUNCT
ajst-392	93	1	#	#	ADJ
ajst-392	93	2	p<0.05	p<0.05	NOUN
ajst-392	93	3	,	,	PUNCT
ajst-392	93	4	#	#	SYM
ajst-392	93	5	#	#	SYM
ajst-392	93	6	p<0.01	p<0.01	PROPN
ajst-392	93	7	,	,	PUNCT
ajst-392	93	8	#	#	SYM
ajst-392	93	9	#	#	SYM
ajst-392	93	10	#	#	ADJ
ajst-392	93	11	p<0.001,lps	p<0.001,lps	ADP
ajst-392	93	12	treatment	treatment	NOUN
ajst-392	93	13	group	group	NOUN
ajst-392	93	14	vs	vs	ADP
ajst-392	93	15	different	different	ADJ
ajst-392	93	16	concentrations	concentration	NOUN
ajst-392	93	17	of	of	ADP
ajst-392	93	18	pacap	pacap	NOUN
ajst-392	93	19	treatment	treatment	NOUN
ajst-392	93	20	groups	group	NOUN
ajst-392	93	21	data	datum	NOUN
ajst-392	93	22	are	be	AUX
ajst-392	93	23	presented	present	VERB
ajst-392	93	24	as	as	ADP
ajst-392	93	25	mean	mean	PROPN
ajst-392	93	26	±	±	NUM
ajst-392	93	27	sem	sem	PROPN
ajst-392	93	28	.	.	PUNCT
ajst-392	94	1	figure	figure	NOUN
ajst-392	94	2	4	4	NUM
ajst-392	94	3	.	.	PUNCT
ajst-392	94	4	pacap	pacap	PROPN
ajst-392	94	5	inhibits	inhibit	VERB
ajst-392	94	6	macrophage	macrophage	ADJ
ajst-392	94	7	m1	m1	NOUN
ajst-392	94	8	polarization	polarization	NOUN
ajst-392	94	9	and	and	CCONJ
ajst-392	94	10	inflammatory	inflammatory	ADJ
ajst-392	94	11	response	response	NOUN
ajst-392	94	12	by	by	ADP
ajst-392	94	13	specifically	specifically	ADV
ajst-392	94	14	activating	activate	VERB
ajst-392	94	15	pac1	pac1	NOUN
ajst-392	94	16	receptors	receptor	NOUN
ajst-392	94	17	.	.	PUNCT
ajst-392	95	1	after	after	SCONJ
ajst-392	95	2	lps	lps	PROPN
ajst-392	95	3	stimulated	stimulate	VERB
ajst-392	95	4	cells	cell	NOUN
ajst-392	95	5	12	12	NUM
ajst-392	95	6	h	h	NOUN
ajst-392	95	7	,	,	PUNCT
ajst-392	95	8	receptor	receptor	NOUN
ajst-392	95	9	-	-	PUNCT
ajst-392	95	10	specific	specific	ADJ
ajst-392	95	11	inhibitors	inhibitor	NOUN
ajst-392	95	12	were	be	AUX
ajst-392	95	13	added	add	VERB
ajst-392	95	14	for	for	ADP
ajst-392	95	15	pre	pre	NOUN
ajst-392	95	16	-	-	NOUN
ajst-392	95	17	incubation	incubation	NOUN
ajst-392	95	18	for	for	ADP
ajst-392	95	19	30	30	NUM
ajst-392	95	20	min	min	NOUN
ajst-392	95	21	,	,	PUNCT
ajst-392	95	22	and	and	CCONJ
ajst-392	95	23	then	then	ADV
ajst-392	95	24	0.1	0.1	NUM
ajst-392	95	25	μm	μm	NOUN
ajst-392	95	26	pacap	pacap	NOUN
ajst-392	95	27	was	be	AUX
ajst-392	95	28	added	add	VERB
ajst-392	95	29	to	to	PART
ajst-392	95	30	continue	continue	VERB
ajst-392	95	31	to	to	PART
ajst-392	95	32	culture	culture	VERB
ajst-392	95	33	for	for	ADP
ajst-392	95	34	24	24	NUM
ajst-392	95	35	h	h	NOUN
ajst-392	95	36	,	,	PUNCT
ajst-392	95	37	(	(	PUNCT
ajst-392	95	38	a	a	X
ajst-392	95	39	)	)	PUNCT
ajst-392	95	40	m1	m1	PROPN
ajst-392	95	41	and	and	CCONJ
ajst-392	95	42	m2	m2	PROPN
ajst-392	95	43	marker	marker	NOUN
ajst-392	95	44	gene	gene	NOUN
ajst-392	95	45	transcription	transcription	NOUN
ajst-392	95	46	levels	level	NOUN
ajst-392	95	47	were	be	AUX
ajst-392	95	48	detected	detect	VERB
ajst-392	95	49	by	by	ADP
ajst-392	95	50	rt	rt	PROPN
ajst-392	95	51	-	-	PUNCT
ajst-392	95	52	qpcr.(b	qpcr.(b	NOUN
ajst-392	95	53	)	)	PUNCT
ajst-392	95	54	the	the	DET
ajst-392	95	55	expression	expression	NOUN
ajst-392	95	56	of	of	ADP
ajst-392	95	57	inflammatory	inflammatory	ADJ
ajst-392	95	58	factors	factor	NOUN
ajst-392	95	59	were	be	AUX
ajst-392	95	60	detected	detect	VERB
ajst-392	95	61	by	by	ADP
ajst-392	95	62	western	western	ADJ
ajst-392	95	63	blot	blot	NOUN
ajst-392	95	64	.	.	PUNCT
ajst-392	96	1	*	*	PUNCT
ajst-392	96	2	*	*	PUNCT
ajst-392	96	3	p<0.01	p<0.01	PROPN
ajst-392	96	4	,	,	PUNCT
ajst-392	96	5	*	*	PUNCT
ajst-392	96	6	*	*	PUNCT
ajst-392	96	7	*	*	PUNCT
ajst-392	96	8	p<0.001	p<0.001	PROPN
ajst-392	96	9	,	,	PUNCT
ajst-392	96	10	nc	nc	PROPN
ajst-392	96	11	vs	vs	ADP
ajst-392	96	12	lps	lps	PROPN
ajst-392	96	13	;	;	PUNCT
ajst-392	96	14	#	#	SYM
ajst-392	96	15	#	#	SYM
ajst-392	96	16	p<0.01	p<0.01	PROPN
ajst-392	96	17	,	,	PUNCT
ajst-392	96	18	#	#	SYM
ajst-392	96	19	#	#	SYM
ajst-392	96	20	#	#	NUM
ajst-392	96	21	p<0.001，lps+pacap	p<0.001，lps+pacap	NOUN
ajst-392	96	22	vs	vs	ADP
ajst-392	96	23	lps	lps	PROPN
ajst-392	96	24	or	or	CCONJ
ajst-392	96	25	lps+pacap+max.d.4	lps+pacap+max.d.4	NOUN
ajst-392	96	26	.	.	PUNCT
ajst-392	97	1	data	datum	NOUN
ajst-392	97	2	are	be	AUX
ajst-392	97	3	presented	present	VERB
ajst-392	97	4	as	as	ADP
ajst-392	97	5	mean	mean	PROPN
ajst-392	97	6	±	±	NUM
ajst-392	97	7	sem	sem	NOUN
ajst-392	97	8	.	.	PROPN
ajst-392	98	1	15	15	NUM
ajst-392	98	2	3.5	3.5	NUM
ajst-392	98	3	.	.	PUNCT
ajst-392	99	1	pacap	pacap	PROPN
ajst-392	99	2	inhibits	inhibit	VERB
ajst-392	99	3	nf	nf	ADJ
ajst-392	99	4	-	-	PUNCT
ajst-392	99	5	κb	κb	NOUN
ajst-392	99	6	signaling	signal	VERB
ajst-392	99	7	pathway	pathway	NOUN
ajst-392	99	8	in	in	ADP
ajst-392	99	9	raw264.7	raw264.7	PROPN
ajst-392	99	10	cells	cell	NOUN
ajst-392	99	11	the	the	DET
ajst-392	99	12	nf	nf	ADJ
ajst-392	99	13	-	-	PUNCT
ajst-392	99	14	κb	κb	NOUN
ajst-392	99	15	signaling	signal	VERB
ajst-392	99	16	pathway	pathway	NOUN
ajst-392	99	17	is	be	AUX
ajst-392	99	18	one	one	NUM
ajst-392	99	19	of	of	ADP
ajst-392	99	20	the	the	DET
ajst-392	99	21	classic	classic	ADJ
ajst-392	99	22	pathways	pathway	NOUN
ajst-392	99	23	activated	activate	VERB
ajst-392	99	24	by	by	ADP
ajst-392	99	25	lps	lps	PROPN
ajst-392	99	26	and	and	CCONJ
ajst-392	99	27	plays	play	VERB
ajst-392	99	28	an	an	DET
ajst-392	99	29	important	important	ADJ
ajst-392	99	30	role	role	NOUN
ajst-392	99	31	in	in	ADP
ajst-392	99	32	mediating	mediate	VERB
ajst-392	99	33	inflammatory	inflammatory	ADJ
ajst-392	99	34	responses	response	NOUN
ajst-392	99	35	,	,	PUNCT
ajst-392	99	36	so	so	SCONJ
ajst-392	99	37	we	we	PRON
ajst-392	99	38	further	far	ADV
ajst-392	99	39	investigated	investigate	VERB
ajst-392	99	40	whether	whether	SCONJ
ajst-392	99	41	pacap	pacap	NOUN
ajst-392	99	42	exerts	exert	VERB
ajst-392	99	43	anti	anti	ADJ
ajst-392	99	44	-	-	ADJ
ajst-392	99	45	inflammatory	inflammatory	ADJ
ajst-392	99	46	activity	activity	NOUN
ajst-392	99	47	by	by	ADP
ajst-392	99	48	regulating	regulate	VERB
ajst-392	99	49	nf	nf	ADJ
ajst-392	99	50	-	-	PUNCT
ajst-392	99	51	κb	κb	NOUN
ajst-392	99	52	signaling	signaling	NOUN
ajst-392	99	53	.	.	PUNCT
ajst-392	100	1	studies	study	NOUN
ajst-392	100	2	have	have	AUX
ajst-392	100	3	shown	show	VERB
ajst-392	100	4	that	that	SCONJ
ajst-392	100	5	nf	nf	ADJ
ajst-392	100	6	-	-	PUNCT
ajst-392	100	7	κb	κb	NOUN
ajst-392	100	8	activity	activity	NOUN
ajst-392	100	9	is	be	AUX
ajst-392	100	10	regulated	regulate	VERB
ajst-392	100	11	by	by	ADP
ajst-392	100	12	the	the	DET
ajst-392	100	13	upstream	upstream	ADJ
ajst-392	100	14	ikk	ikk	PROPN
ajst-392	100	15	complex	complex	NOUN
ajst-392	100	16	and	and	CCONJ
ajst-392	100	17	iκbα	iκbα	NOUN
ajst-392	100	18	.	.	PUNCT
ajst-392	101	1	when	when	SCONJ
ajst-392	101	2	the	the	DET
ajst-392	101	3	inflammatory	inflammatory	ADJ
ajst-392	101	4	reaction	reaction	NOUN
ajst-392	101	5	occurs	occur	VERB
ajst-392	101	6	,	,	PUNCT
ajst-392	101	7	the	the	DET
ajst-392	101	8	ikk	ikk	PROPN
ajst-392	101	9	complex	complex	NOUN
ajst-392	101	10	activates	activate	VERB
ajst-392	101	11	and	and	CCONJ
ajst-392	101	12	phosphorylates	phosphorylate	NOUN
ajst-392	101	13	iκbα	iκbα	ADV
ajst-392	101	14	,	,	PUNCT
ajst-392	101	15	which	which	PRON
ajst-392	101	16	relieves	relieve	VERB
ajst-392	101	17	the	the	DET
ajst-392	101	18	inhibition	inhibition	NOUN
ajst-392	101	19	of	of	ADP
ajst-392	101	20	nf	nf	NOUN
ajst-392	101	21	-	-	PUNCT
ajst-392	101	22	κb	κb	NOUN
ajst-392	101	23	,	,	PUNCT
ajst-392	101	24	and	and	CCONJ
ajst-392	101	25	the	the	DET
ajst-392	101	26	phosphorylation	phosphorylation	NOUN
ajst-392	101	27	of	of	ADP
ajst-392	101	28	nf	nf	NOUN
ajst-392	101	29	-	-	PUNCT
ajst-392	101	30	κb	κb	ADJ
ajst-392	101	31	p65	p65	NOUN
ajst-392	101	32	is	be	AUX
ajst-392	101	33	incorporated	incorporate	VERB
ajst-392	101	34	into	into	ADP
ajst-392	101	35	the	the	DET
ajst-392	101	36	nucleus	nucleus	NOUN
ajst-392	101	37	to	to	PART
ajst-392	101	38	initiate	initiate	VERB
ajst-392	101	39	the	the	DET
ajst-392	101	40	transcription	transcription	NOUN
ajst-392	101	41	of	of	ADP
ajst-392	101	42	target	target	NOUN
ajst-392	101	43	genes	gene	NOUN
ajst-392	101	44	.	.	PUNCT
ajst-392	102	1	therefore	therefore	ADV
ajst-392	102	2	,	,	PUNCT
ajst-392	102	3	we	we	PRON
ajst-392	102	4	detected	detect	VERB
ajst-392	102	5	the	the	DET
ajst-392	102	6	phosphorylation	phosphorylation	NOUN
ajst-392	102	7	levels	level	NOUN
ajst-392	102	8	of	of	ADP
ajst-392	102	9	ikk2	ikk2	PROPN
ajst-392	102	10	,	,	PUNCT
ajst-392	102	11	iκbα	iκbα	ADV
ajst-392	102	12	,	,	PUNCT
ajst-392	102	13	and	and	CCONJ
ajst-392	102	14	nf	nf	X
ajst-392	102	15	-	-	PUNCT
ajst-392	102	16	κb	κb	NOUN
ajst-392	102	17	,	,	PUNCT
ajst-392	102	18	and	and	CCONJ
ajst-392	102	19	the	the	DET
ajst-392	102	20	results	result	NOUN
ajst-392	102	21	showed	show	VERB
ajst-392	102	22	that	that	SCONJ
ajst-392	102	23	the	the	DET
ajst-392	102	24	phosphorylation	phosphorylation	NOUN
ajst-392	102	25	of	of	ADP
ajst-392	102	26	ikk2	ikk2	PROPN
ajst-392	102	27	,	,	PUNCT
ajst-392	102	28	iκbα	iκbα	ADV
ajst-392	102	29	,	,	PUNCT
ajst-392	102	30	and	and	CCONJ
ajst-392	102	31	nf	nf	X
ajst-392	102	32	-	-	PUNCT
ajst-392	102	33	κb	κb	PROPN
ajst-392	102	34	was	be	AUX
ajst-392	102	35	enhanced	enhance	VERB
ajst-392	102	36	after	after	ADP
ajst-392	102	37	lps	lps	PROPN
ajst-392	102	38	stimulation	stimulation	NOUN
ajst-392	102	39	,	,	PUNCT
ajst-392	102	40	and	and	CCONJ
ajst-392	102	41	pacap	pacap	VERB
ajst-392	102	42	significantly	significantly	ADV
ajst-392	102	43	reduced	reduce	VERB
ajst-392	102	44	the	the	DET
ajst-392	102	45	phosphorylation	phosphorylation	NOUN
ajst-392	102	46	levels	level	NOUN
ajst-392	102	47	of	of	ADP
ajst-392	102	48	ikk2	ikk2	PROPN
ajst-392	102	49	,	,	PUNCT
ajst-392	102	50	iκbα	iκbα	ADV
ajst-392	102	51	,	,	PUNCT
ajst-392	102	52	and	and	CCONJ
ajst-392	102	53	nf	nf	X
ajst-392	102	54	-	-	PUNCT
ajst-392	102	55	κb	κb	NOUN
ajst-392	102	56	,	,	PUNCT
ajst-392	102	57	suggesting	suggest	VERB
ajst-392	102	58	that	that	SCONJ
ajst-392	102	59	the	the	DET
ajst-392	102	60	anti	anti	ADJ
ajst-392	102	61	-	-	ADJ
ajst-392	102	62	inflammatory	inflammatory	ADJ
ajst-392	102	63	activity	activity	NOUN
ajst-392	102	64	of	of	ADP
ajst-392	102	65	pacap	pacap	NOUN
ajst-392	102	66	depends	depend	VERB
ajst-392	102	67	on	on	ADP
ajst-392	102	68	the	the	DET
ajst-392	102	69	regulation	regulation	NOUN
ajst-392	102	70	of	of	ADP
ajst-392	102	71	nf	nf	ADJ
ajst-392	102	72	-	-	PUNCT
ajst-392	102	73	κb	κb	NOUN
ajst-392	102	74	signaling	signal	VERB
ajst-392	102	75	pathway	pathway	NOUN
ajst-392	102	76	(	(	PUNCT
ajst-392	102	77	fig	fig	NOUN
ajst-392	102	78	5	5	NUM
ajst-392	102	79	)	)	PUNCT
ajst-392	102	80	.	.	PUNCT
ajst-392	103	1	pacap	pacap	NOUN
ajst-392	103	2	may	may	AUX
ajst-392	103	3	improve	improve	VERB
ajst-392	103	4	lps	lps	PROPN
ajst-392	103	5	-	-	PUNCT
ajst-392	103	6	induced	induce	VERB
ajst-392	103	7	inflammatory	inflammatory	ADJ
ajst-392	103	8	response	response	NOUN
ajst-392	103	9	by	by	ADP
ajst-392	103	10	regulating	regulate	VERB
ajst-392	103	11	tlr4	tlr4	PROPN
ajst-392	103	12	/	/	SYM
ajst-392	103	13	ikk2	ikk2	PROPN
ajst-392	103	14	/	/	PUNCT
ajst-392	103	15	iκbα	iκbα	NOUN
ajst-392	103	16	/	/	SYM
ajst-392	103	17	nf	nf	NOUN
ajst-392	103	18	-	-	PUNCT
ajst-392	103	19	κb	κb	NOUN
ajst-392	103	20	signaling	signal	VERB
ajst-392	103	21	pathway	pathway	NOUN
ajst-392	103	22	.	.	PUNCT
ajst-392	104	1	figure	figure	NOUN
ajst-392	104	2	5	5	NUM
ajst-392	104	3	.	.	PUNCT
ajst-392	104	4	pacap	pacap	PROPN
ajst-392	104	5	inhibited	inhibit	VERB
ajst-392	104	6	lps	lps	PROPN
ajst-392	104	7	-	-	PUNCT
ajst-392	104	8	induced	induce	VERB
ajst-392	104	9	nf	nf	ADJ
ajst-392	104	10	-	-	PUNCT
ajst-392	104	11	κb	κb	NOUN
ajst-392	104	12	signaling	signal	VERB
ajst-392	104	13	pathway	pathway	NOUN
ajst-392	104	14	.	.	PUNCT
ajst-392	105	1	after	after	SCONJ
ajst-392	105	2	lps	lps	PROPN
ajst-392	105	3	stimulation	stimulation	VERB
ajst-392	105	4	12	12	NUM
ajst-392	105	5	h	h	NOUN
ajst-392	105	6	,	,	PUNCT
ajst-392	105	7	the	the	DET
ajst-392	105	8	protein	protein	NOUN
ajst-392	105	9	expressions	expression	NOUN
ajst-392	105	10	of	of	ADP
ajst-392	105	11	ikk2	ikk2	PROPN
ajst-392	105	12	/	/	SYM
ajst-392	105	13	p	p	PROPN
ajst-392	105	14	-	-	PUNCT
ajst-392	105	15	ikk2	ikk2	PROPN
ajst-392	105	16	,	,	PUNCT
ajst-392	105	17	iκbα	iκbα	ADV
ajst-392	105	18	/	/	SYM
ajst-392	105	19	p	p	NOUN
ajst-392	105	20	-	-	PUNCT
ajst-392	105	21	iκbα	iκbα	NOUN
ajst-392	105	22	,	,	PUNCT
ajst-392	105	23	and	and	CCONJ
ajst-392	105	24	p	p	X
ajst-392	105	25	-	-	PUNCT
ajst-392	105	26	p65	p65	NOUN
ajst-392	105	27	were	be	AUX
ajst-392	105	28	detected	detect	VERB
ajst-392	105	29	by	by	ADP
ajst-392	105	30	western	western	ADJ
ajst-392	105	31	blot	blot	NOUN
ajst-392	105	32	.	.	PUNCT
ajst-392	106	1	(	(	PUNCT
ajst-392	106	2	a	a	X
ajst-392	106	3	)	)	PUNCT
ajst-392	106	4	western	western	ADJ
ajst-392	106	5	blot	blot	NOUN
ajst-392	106	6	,	,	PUNCT
ajst-392	106	7	(	(	PUNCT
ajst-392	106	8	b	b	X
ajst-392	106	9	)	)	PUNCT
ajst-392	106	10	blot	blot	NOUN
ajst-392	106	11	quantitative	quantitative	ADJ
ajst-392	106	12	analysis	analysis	NOUN
ajst-392	106	13	.	.	PUNCT
ajst-392	107	1	normalized	normalize	VERB
ajst-392	107	2	by	by	ADP
ajst-392	107	3	relative	relative	ADJ
ajst-392	107	4	intensities	intensity	NOUN
ajst-392	107	5	of	of	ADP
ajst-392	107	6	β	β	NOUN
ajst-392	107	7	-	-	NOUN
ajst-392	107	8	actin	actin	NOUN
ajst-392	107	9	.	.	PUNCT
ajst-392	108	1	*	*	PUNCT
ajst-392	108	2	*	*	PUNCT
ajst-392	108	3	p<0.01	p<0.01	PROPN
ajst-392	108	4	,	,	PUNCT
ajst-392	108	5	*	*	PUNCT
ajst-392	108	6	*	*	PUNCT
ajst-392	108	7	*	*	PUNCT
ajst-392	108	8	p<0.001	p<0.001	PROPN
ajst-392	108	9	,	,	PUNCT
ajst-392	108	10	nc	nc	PROPN
ajst-392	108	11	vs	vs	ADP
ajst-392	108	12	lps	lps	PROPN
ajst-392	108	13	;	;	PUNCT
ajst-392	108	14	#	#	SYM
ajst-392	108	15	#	#	SYM
ajst-392	108	16	p<0.01	p<0.01	PROPN
ajst-392	108	17	,	,	PUNCT
ajst-392	108	18	#	#	SYM
ajst-392	108	19	#	#	SYM
ajst-392	108	20	#	#	NOUN
ajst-392	108	21	p<0.001	p<0.001	NOUN
ajst-392	108	22	,	,	PUNCT
ajst-392	108	23	lps+pacap	lps+pacap	NOUN
ajst-392	108	24	vs	vs	ADP
ajst-392	108	25	lps	lps	PROPN
ajst-392	108	26	or	or	CCONJ
ajst-392	108	27	lps+pacap+max.d.4	lps+pacap+max.d.4	NOUN
ajst-392	108	28	.	.	PUNCT
ajst-392	109	1	data	datum	NOUN
ajst-392	109	2	are	be	AUX
ajst-392	109	3	presented	present	VERB
ajst-392	109	4	as	as	ADP
ajst-392	109	5	mean	mean	PROPN
ajst-392	109	6	±	±	NUM
ajst-392	109	7	sem	sem	NOUN
ajst-392	109	8	.	.	PROPN
ajst-392	110	1	3.6	3.6	NUM
ajst-392	110	2	.	.	PUNCT
ajst-392	111	1	pacap	pacap	PROPN
ajst-392	111	2	inhibits	inhibit	VERB
ajst-392	111	3	the	the	DET
ajst-392	111	4	activation	activation	NOUN
ajst-392	111	5	of	of	ADP
ajst-392	111	6	mapks	mapks	NOUN
ajst-392	111	7	components	component	NOUN
ajst-392	111	8	in	in	ADP
ajst-392	111	9	raw264.7	raw264.7	PROPN
ajst-392	111	10	cells	cell	NOUN
ajst-392	111	11	similarly	similarly	ADV
ajst-392	111	12	,	,	PUNCT
ajst-392	111	13	mitogen	mitogen	NOUN
ajst-392	111	14	-	-	PUNCT
ajst-392	111	15	activated	activate	VERB
ajst-392	111	16	protein	protein	NOUN
ajst-392	111	17	kinase	kinase	PROPN
ajst-392	111	18	family	family	NOUN
ajst-392	111	19	members	member	NOUN
ajst-392	111	20	are	be	AUX
ajst-392	111	21	also	also	ADV
ajst-392	111	22	involved	involve	VERB
ajst-392	111	23	in	in	ADP
ajst-392	111	24	inflammatory	inflammatory	ADJ
ajst-392	111	25	responses	response	NOUN
ajst-392	111	26	.	.	PUNCT
ajst-392	112	1	we	we	PRON
ajst-392	112	2	evaluated	evaluate	VERB
ajst-392	112	3	the	the	DET
ajst-392	112	4	effect	effect	NOUN
ajst-392	112	5	of	of	ADP
ajst-392	112	6	pacap	pacap	NOUN
ajst-392	112	7	on	on	ADP
ajst-392	112	8	lps	lps	PROPN
ajst-392	112	9	-	-	PUNCT
ajst-392	112	10	induced	induce	VERB
ajst-392	112	11	activity	activity	NOUN
ajst-392	112	12	of	of	ADP
ajst-392	112	13	mapks	mapks	NOUN
ajst-392	112	14	in	in	ADP
ajst-392	112	15	raw264.7	raw264.7	PROPN
ajst-392	112	16	cells	cell	NOUN
ajst-392	112	17	.	.	PUNCT
ajst-392	113	1	as	as	SCONJ
ajst-392	113	2	shown	show	VERB
ajst-392	113	3	in	in	ADP
ajst-392	113	4	the	the	DET
ajst-392	113	5	figure	figure	NOUN
ajst-392	113	6	,	,	PUNCT
ajst-392	113	7	the	the	DET
ajst-392	113	8	phosphorylation	phosphorylation	NOUN
ajst-392	113	9	levels	level	NOUN
ajst-392	113	10	of	of	ADP
ajst-392	113	11	p38	p38	NOUN
ajst-392	113	12	and	and	CCONJ
ajst-392	113	13	jnk	jnk	PROPN
ajst-392	113	14	in	in	ADP
ajst-392	113	15	raw264.7	raw264.7	PROPN
ajst-392	113	16	cells	cell	NOUN
ajst-392	113	17	were	be	AUX
ajst-392	113	18	significantly	significantly	ADV
ajst-392	113	19	increased	increase	VERB
ajst-392	113	20	after	after	ADP
ajst-392	113	21	lps	lps	PROPN
ajst-392	113	22	treatment	treatment	NOUN
ajst-392	113	23	,	,	PUNCT
ajst-392	113	24	and	and	CCONJ
ajst-392	113	25	the	the	DET
ajst-392	113	26	phosphorylation	phosphorylation	NOUN
ajst-392	113	27	of	of	ADP
ajst-392	113	28	jnk	jnk	PROPN
ajst-392	113	29	and	and	CCONJ
ajst-392	113	30	p38	p38	NOUN
ajst-392	113	31	was	be	AUX
ajst-392	113	32	down	down	ADV
ajst-392	113	33	-	-	PUNCT
ajst-392	113	34	regulated	regulate	VERB
ajst-392	113	35	after	after	ADP
ajst-392	113	36	pacap	pacap	NOUN
ajst-392	113	37	treatment	treatment	NOUN
ajst-392	113	38	,	,	PUNCT
ajst-392	113	39	but	but	CCONJ
ajst-392	113	40	the	the	DET
ajst-392	113	41	phosphorylation	phosphorylation	NOUN
ajst-392	113	42	of	of	ADP
ajst-392	113	43	erk	erk	PROPN
ajst-392	113	44	was	be	AUX
ajst-392	113	45	not	not	PART
ajst-392	113	46	down	down	ADV
ajst-392	113	47	-	-	PUNCT
ajst-392	113	48	regulated	regulate	VERB
ajst-392	113	49	(	(	PUNCT
ajst-392	113	50	data	datum	NOUN
ajst-392	113	51	not	not	PART
ajst-392	113	52	shown	show	VERB
ajst-392	113	53	)	)	PUNCT
ajst-392	113	54	.	.	PUNCT
ajst-392	114	1	it	it	PRON
ajst-392	114	2	is	be	AUX
ajst-392	114	3	suggested	suggest	VERB
ajst-392	114	4	that	that	SCONJ
ajst-392	114	5	pacap	pacap	NOUN
ajst-392	114	6	exerts	exert	VERB
ajst-392	114	7	anti	anti	ADJ
ajst-392	114	8	-	-	ADJ
ajst-392	114	9	inflammatory	inflammatory	ADJ
ajst-392	114	10	activity	activity	NOUN
ajst-392	114	11	to	to	ADP
ajst-392	114	12	a	a	DET
ajst-392	114	13	certain	certain	ADJ
ajst-392	114	14	extent	extent	NOUN
ajst-392	114	15	by	by	ADP
ajst-392	114	16	selectively	selectively	ADV
ajst-392	114	17	inhibiting	inhibit	VERB
ajst-392	114	18	the	the	DET
ajst-392	114	19	phosphorylation	phosphorylation	NOUN
ajst-392	114	20	of	of	ADP
ajst-392	114	21	jnk	jnk	PROPN
ajst-392	114	22	and	and	CCONJ
ajst-392	114	23	p38	p38	NOUN
ajst-392	114	24	.	.	PUNCT
ajst-392	115	1	16	16	NUM
ajst-392	115	2	figure	figure	NOUN
ajst-392	115	3	6	6	NUM
ajst-392	115	4	.	.	PUNCT
ajst-392	115	5	pacap	pacap	PROPN
ajst-392	115	6	inhibits	inhibit	VERB
ajst-392	115	7	the	the	DET
ajst-392	115	8	phosphorylation	phosphorylation	NOUN
ajst-392	115	9	of	of	ADP
ajst-392	115	10	jnk	jnk	PROPN
ajst-392	115	11	and	and	CCONJ
ajst-392	115	12	p38	p38	NOUN
ajst-392	115	13	in	in	ADP
ajst-392	115	14	raw264.7	raw264.7	NOUN
ajst-392	115	15	cells	cell	NOUN
ajst-392	115	16	.	.	PUNCT
ajst-392	116	1	after	after	SCONJ
ajst-392	116	2	lps	lps	PROPN
ajst-392	116	3	stimulation	stimulation	VERB
ajst-392	116	4	12	12	NUM
ajst-392	116	5	h	h	NOUN
ajst-392	116	6	,	,	PUNCT
ajst-392	116	7	western	western	ADJ
ajst-392	116	8	blot	blot	NOUN
ajst-392	116	9	was	be	AUX
ajst-392	116	10	used	use	VERB
ajst-392	116	11	to	to	PART
ajst-392	116	12	detect	detect	VERB
ajst-392	116	13	the	the	DET
ajst-392	116	14	expression	expression	NOUN
ajst-392	116	15	of	of	ADP
ajst-392	116	16	p38	p38	NOUN
ajst-392	116	17	/	/	SYM
ajst-392	116	18	p	p	NOUN
ajst-392	116	19	-	-	PUNCT
ajst-392	116	20	p38	p38	NOUN
ajst-392	116	21	and	and	CCONJ
ajst-392	116	22	jnk	jnk	PROPN
ajst-392	116	23	/	/	SYM
ajst-392	116	24	p	p	PROPN
ajst-392	116	25	-	-	PUNCT
ajst-392	116	26	jnk	jnk	NOUN
ajst-392	116	27	.	.	PUNCT
ajst-392	117	1	(	(	PUNCT
ajst-392	117	2	a	a	X
ajst-392	117	3	)	)	PUNCT
ajst-392	117	4	western	western	ADJ
ajst-392	117	5	blot	blot	NOUN
ajst-392	117	6	,	,	PUNCT
ajst-392	117	7	(	(	PUNCT
ajst-392	117	8	b	b	X
ajst-392	117	9	)	)	PUNCT
ajst-392	117	10	western	western	ADJ
ajst-392	117	11	blot	blot	NOUN
ajst-392	117	12	quantitative	quantitative	ADJ
ajst-392	117	13	analysis	analysis	NOUN
ajst-392	117	14	.	.	PUNCT
ajst-392	118	1	normalized	normalize	VERB
ajst-392	118	2	by	by	ADP
ajst-392	118	3	relative	relative	ADJ
ajst-392	118	4	intensities	intensity	NOUN
ajst-392	118	5	of	of	ADP
ajst-392	118	6	β	β	NOUN
ajst-392	118	7	-	-	NOUN
ajst-392	118	8	actin	actin	NOUN
ajst-392	118	9	.	.	PUNCT
ajst-392	119	1	*	*	PUNCT
ajst-392	119	2	*	*	PUNCT
ajst-392	119	3	p<0.01	p<0.01	PROPN
ajst-392	119	4	,	,	PUNCT
ajst-392	119	5	*	*	PUNCT
ajst-392	119	6	*	*	PUNCT
ajst-392	119	7	*	*	PUNCT
ajst-392	119	8	p<0.001	p<0.001	PROPN
ajst-392	119	9	,	,	PUNCT
ajst-392	119	10	nc	nc	PROPN
ajst-392	119	11	vs	vs	ADP
ajst-392	119	12	lps	lps	PROPN
ajst-392	119	13	;	;	PUNCT
ajst-392	119	14	#	#	SYM
ajst-392	119	15	#	#	SYM
ajst-392	119	16	p<0.01	p<0.01	PROPN
ajst-392	119	17	,	,	PUNCT
ajst-392	119	18	#	#	SYM
ajst-392	119	19	#	#	SYM
ajst-392	119	20	#	#	NUM
ajst-392	119	21	p<0.001，lps+pacap	p<0.001，lps+pacap	NOUN
ajst-392	119	22	vs	vs	ADP
ajst-392	119	23	lps	lps	PROPN
ajst-392	119	24	or	or	CCONJ
ajst-392	119	25	lps+pacap+max.d4	lps+pacap+max.d4	PROPN
ajst-392	119	26	.	.	PUNCT
ajst-392	120	1	data	datum	NOUN
ajst-392	120	2	are	be	AUX
ajst-392	120	3	presented	present	VERB
ajst-392	120	4	as	as	ADP
ajst-392	120	5	mean	mean	PROPN
ajst-392	120	6	±	±	NUM
ajst-392	120	7	sem	sem	NOUN
ajst-392	120	8	.	.	PROPN
ajst-392	121	1	3.7	3.7	NUM
ajst-392	121	2	.	.	PUNCT
ajst-392	122	1	pacap	pacap	PROPN
ajst-392	122	2	mediates	mediate	VERB
ajst-392	122	3	anti	anti	ADJ
ajst-392	122	4	-	-	ADJ
ajst-392	122	5	inflammatory	inflammatory	ADJ
ajst-392	122	6	effects	effect	NOUN
ajst-392	122	7	through	through	ADP
ajst-392	122	8	the	the	DET
ajst-392	122	9	pac1	pac1	NOUN
ajst-392	122	10	/	/	SYM
ajst-392	122	11	camp	camp	NOUN
ajst-392	122	12	/	/	SYM
ajst-392	122	13	pka	pka	PROPN
ajst-392	122	14	pathway	pathway	NOUN
ajst-392	122	15	pacap	pacap	NOUN
ajst-392	122	16	can	can	AUX
ajst-392	122	17	exert	exert	VERB
ajst-392	122	18	different	different	ADJ
ajst-392	122	19	biological	biological	ADJ
ajst-392	122	20	effects	effect	NOUN
ajst-392	122	21	by	by	ADP
ajst-392	122	22	activating	activate	VERB
ajst-392	122	23	different	different	ADJ
ajst-392	122	24	signal	signal	NOUN
ajst-392	122	25	transduction	transduction	NOUN
ajst-392	122	26	pathways	pathway	NOUN
ajst-392	122	27	.	.	PUNCT
ajst-392	123	1	therefore	therefore	ADV
ajst-392	123	2	,	,	PUNCT
ajst-392	123	3	in	in	ADP
ajst-392	123	4	order	order	NOUN
ajst-392	123	5	to	to	PART
ajst-392	123	6	further	far	ADV
ajst-392	123	7	clarify	clarify	VERB
ajst-392	123	8	the	the	DET
ajst-392	123	9	mechanism	mechanism	NOUN
ajst-392	123	10	of	of	ADP
ajst-392	123	11	pacap	pacap	NOUN
ajst-392	123	12	inhibiting	inhibit	VERB
ajst-392	123	13	the	the	DET
ajst-392	123	14	lpsinduced	lpsinduce	VERB
ajst-392	123	15	nf	nf	INTJ
ajst-392	123	16	-	-	PUNCT
ajst-392	123	17	κb	κb	NOUN
ajst-392	123	18	and	and	CCONJ
ajst-392	123	19	mapks	mapks	NOUN
ajst-392	123	20	pathways	pathway	NOUN
ajst-392	123	21	,	,	PUNCT
ajst-392	123	22	raw264.7	raw264.7	PROPN
ajst-392	123	23	cells	cell	NOUN
ajst-392	123	24	were	be	AUX
ajst-392	123	25	treated	treat	VERB
ajst-392	123	26	with	with	ADP
ajst-392	123	27	0.1	0.1	NUM
ajst-392	123	28	μg	μg	NOUN
ajst-392	123	29	/	/	SYM
ajst-392	123	30	ml	ml	ADP
ajst-392	123	31	lps	lps	PROPN
ajst-392	123	32	for	for	ADP
ajst-392	123	33	12	12	NUM
ajst-392	123	34	h	h	NOUN
ajst-392	123	35	,	,	PUNCT
ajst-392	123	36	and	and	CCONJ
ajst-392	123	37	the	the	DET
ajst-392	123	38	cells	cell	NOUN
ajst-392	123	39	were	be	AUX
ajst-392	123	40	preincubated	preincubate	VERB
ajst-392	123	41	with	with	ADP
ajst-392	123	42	30	30	NUM
ajst-392	123	43	μm	μm	NOUN
ajst-392	123	44	h89	h89	NOUN
ajst-392	123	45	(	(	PUNCT
ajst-392	123	46	camp	camp	NOUN
ajst-392	123	47	/	/	SYM
ajst-392	123	48	pka	pka	PROPN
ajst-392	123	49	pathway	pathway	NOUN
ajst-392	123	50	specific	specific	ADJ
ajst-392	123	51	inhibitor	inhibitor	NOUN
ajst-392	123	52	)	)	PUNCT
ajst-392	123	53	for	for	ADP
ajst-392	123	54	30	30	NUM
ajst-392	123	55	minutes	minute	NOUN
ajst-392	123	56	.	.	PUNCT
ajst-392	124	1	as	as	SCONJ
ajst-392	124	2	shown	show	VERB
ajst-392	124	3	,	,	PUNCT
ajst-392	124	4	the	the	DET
ajst-392	124	5	inhibitory	inhibitory	ADJ
ajst-392	124	6	effect	effect	NOUN
ajst-392	124	7	of	of	ADP
ajst-392	124	8	pacap	pacap	NOUN
ajst-392	124	9	on	on	ADP
ajst-392	124	10	lps	lps	PROPN
ajst-392	124	11	-	-	PUNCT
ajst-392	124	12	induced	induce	VERB
ajst-392	124	13	tlr4	tlr4	NOUN
ajst-392	124	14	expression	expression	NOUN
ajst-392	124	15	and	and	CCONJ
ajst-392	124	16	phosphorylation	phosphorylation	NOUN
ajst-392	124	17	of	of	ADP
ajst-392	124	18	ikk2	ikk2	PROPN
ajst-392	124	19	,	,	PUNCT
ajst-392	124	20	iκbα	iκbα	NOUN
ajst-392	124	21	,	,	PUNCT
ajst-392	124	22	p65	p65	NOUN
ajst-392	124	23	,	,	PUNCT
ajst-392	124	24	jnk	jnk	PROPN
ajst-392	124	25	,	,	PUNCT
ajst-392	124	26	and	and	CCONJ
ajst-392	124	27	p38	p38	NOUN
ajst-392	124	28	was	be	AUX
ajst-392	124	29	counteracted	counteract	VERB
ajst-392	124	30	by	by	ADP
ajst-392	124	31	the	the	DET
ajst-392	124	32	addition	addition	NOUN
ajst-392	124	33	of	of	ADP
ajst-392	124	34	h89(fig	h89(fig	PROPN
ajst-392	124	35	7	7	NUM
ajst-392	124	36	)	)	PUNCT
ajst-392	124	37	.	.	PUNCT
ajst-392	125	1	it	it	PRON
ajst-392	125	2	indicated	indicate	VERB
ajst-392	125	3	that	that	SCONJ
ajst-392	125	4	pacap	pacap	NOUN
ajst-392	125	5	inhibited	inhibit	VERB
ajst-392	125	6	the	the	DET
ajst-392	125	7	m1	m1	PROPN
ajst-392	125	8	polarization	polarization	NOUN
ajst-392	125	9	of	of	ADP
ajst-392	125	10	macrophages	macrophage	NOUN
ajst-392	125	11	and	and	CCONJ
ajst-392	125	12	improved	improve	VERB
ajst-392	125	13	the	the	DET
ajst-392	125	14	inflammatory	inflammatory	ADJ
ajst-392	125	15	response	response	NOUN
ajst-392	125	16	through	through	ADP
ajst-392	125	17	the	the	DET
ajst-392	125	18	pac1	pac1	NOUN
ajst-392	125	19	/	/	SYM
ajst-392	125	20	camp	camp	NOUN
ajst-392	125	21	/	/	SYM
ajst-392	125	22	pka	pka	PROPN
ajst-392	125	23	pathway	pathway	NOUN
ajst-392	125	24	.	.	PUNCT
ajst-392	126	1	figure	figure	NOUN
ajst-392	126	2	7	7	NUM
ajst-392	126	3	.	.	PUNCT
ajst-392	127	1	pacap	pacap	PROPN
ajst-392	127	2	mediates	mediate	VERB
ajst-392	127	3	anti	anti	ADJ
ajst-392	127	4	-	-	ADJ
ajst-392	127	5	inflammatory	inflammatory	ADJ
ajst-392	127	6	effects	effect	NOUN
ajst-392	127	7	through	through	ADP
ajst-392	127	8	the	the	DET
ajst-392	127	9	pac1	pac1	NOUN
ajst-392	127	10	/	/	SYM
ajst-392	127	11	camp	camp	NOUN
ajst-392	127	12	/	/	SYM
ajst-392	127	13	pka	pka	NOUN
ajst-392	127	14	pathway	pathway	NOUN
ajst-392	127	15	.	.	PUNCT
ajst-392	128	1	after	after	ADP
ajst-392	128	2	h89	h89	NOUN
ajst-392	128	3	preincubation	preincubation	NOUN
ajst-392	128	4	,	,	PUNCT
ajst-392	128	5	western	western	ADJ
ajst-392	128	6	blot	blot	NOUN
ajst-392	128	7	was	be	AUX
ajst-392	128	8	used	use	VERB
ajst-392	128	9	to	to	PART
ajst-392	128	10	detect	detect	VERB
ajst-392	128	11	the	the	DET
ajst-392	128	12	phosphorylation	phosphorylation	NOUN
ajst-392	128	13	levels	level	NOUN
ajst-392	128	14	of	of	ADP
ajst-392	128	15	nf	nf	NOUN
ajst-392	128	16	-	-	PUNCT
ajst-392	128	17	κb	κb	NOUN
ajst-392	128	18	and	and	CCONJ
ajst-392	128	19	mapks	mapks	NOUN
ajst-392	128	20	pathway	pathway	NOUN
ajst-392	128	21	proteins	protein	NOUN
ajst-392	128	22	.	.	PUNCT
ajst-392	129	1	(	(	PUNCT
ajst-392	129	2	a	a	X
ajst-392	129	3	)	)	PUNCT
ajst-392	129	4	nf	nf	ADJ
ajst-392	129	5	-	-	PUNCT
ajst-392	129	6	κb	κb	NOUN
ajst-392	129	7	pathway	pathway	NOUN
ajst-392	129	8	protein	protein	NOUN
ajst-392	129	9	bands	band	NOUN
ajst-392	129	10	and	and	CCONJ
ajst-392	129	11	their	their	PRON
ajst-392	129	12	blotting	blot	VERB
ajst-392	129	13	quantitative	quantitative	ADJ
ajst-392	129	14	analysis	analysis	NOUN
ajst-392	129	15	(	(	PUNCT
ajst-392	129	16	b	b	NOUN
ajst-392	129	17	)	)	PUNCT
ajst-392	129	18	mapk	mapk	NOUN
ajst-392	129	19	pathway	pathway	NOUN
ajst-392	129	20	protein	protein	NOUN
ajst-392	129	21	(	(	PUNCT
ajst-392	129	22	jnk	jnk	PROPN
ajst-392	129	23	,	,	PUNCT
ajst-392	129	24	p38	p38	NOUN
ajst-392	129	25	)	)	PUNCT
ajst-392	129	26	bands	band	NOUN
ajst-392	129	27	and	and	CCONJ
ajst-392	129	28	their	their	PRON
ajst-392	129	29	blotting	blot	VERB
ajst-392	129	30	quantitative	quantitative	ADJ
ajst-392	129	31	analysis	analysis	NOUN
ajst-392	129	32	.	.	PUNCT
ajst-392	130	1	*	*	PUNCT
ajst-392	130	2	*	*	PUNCT
ajst-392	130	3	p<0.01	p<0.01	PROPN
ajst-392	130	4	,	,	PUNCT
ajst-392	130	5	*	*	PUNCT
ajst-392	130	6	*	*	PUNCT
ajst-392	130	7	*	*	PUNCT
ajst-392	130	8	p<0.001	p<0.001	PROPN
ajst-392	130	9	,	,	PUNCT
ajst-392	130	10	nc	nc	PROPN
ajst-392	130	11	vs	vs	ADP
ajst-392	130	12	lps	lps	PROPN
ajst-392	130	13	;	;	PUNCT
ajst-392	130	14	#	#	SYM
ajst-392	130	15	#	#	SYM
ajst-392	130	16	p<0.01	p<0.01	PROPN
ajst-392	130	17	,	,	PUNCT
ajst-392	130	18	#	#	SYM
ajst-392	130	19	#	#	SYM
ajst-392	130	20	#	#	NUM
ajst-392	130	21	p<0.001，lps+pacap	p<0.001，lps+pacap	NOUN
ajst-392	130	22	vs	vs	ADP
ajst-392	130	23	lps	lps	PROPN
ajst-392	130	24	.	.	PUNCT
ajst-392	131	1	data	datum	NOUN
ajst-392	131	2	are	be	AUX
ajst-392	131	3	presented	present	VERB
ajst-392	131	4	as	as	ADP
ajst-392	131	5	mean	mean	PROPN
ajst-392	131	6	±	±	NUM
ajst-392	131	7	sem	sem	NOUN
ajst-392	131	8	.	.	PROPN
ajst-392	132	1	17	17	NUM
ajst-392	132	2	4	4	NUM
ajst-392	132	3	.	.	PUNCT
ajst-392	133	1	discussion	discussion	NOUN
ajst-392	133	2	inflammation	inflammation	NOUN
ajst-392	133	3	is	be	AUX
ajst-392	133	4	an	an	DET
ajst-392	133	5	important	important	ADJ
ajst-392	133	6	defense	defense	NOUN
ajst-392	133	7	mechanism	mechanism	NOUN
ajst-392	133	8	for	for	ADP
ajst-392	133	9	the	the	DET
ajst-392	133	10	host	host	NOUN
ajst-392	133	11	to	to	PART
ajst-392	133	12	resist	resist	VERB
ajst-392	133	13	pathogens	pathogen	NOUN
ajst-392	133	14	,	,	PUNCT
ajst-392	133	15	but	but	CCONJ
ajst-392	133	16	excessive	excessive	ADJ
ajst-392	133	17	inflammatory	inflammatory	ADJ
ajst-392	133	18	responses	response	NOUN
ajst-392	133	19	can	can	AUX
ajst-392	133	20	cause	cause	VERB
ajst-392	133	21	damage	damage	NOUN
ajst-392	133	22	to	to	ADP
ajst-392	133	23	tissue	tissue	NOUN
ajst-392	133	24	structure	structure	NOUN
ajst-392	133	25	and	and	CCONJ
ajst-392	133	26	function	function	NOUN
ajst-392	133	27	,	,	PUNCT
ajst-392	133	28	gradually	gradually	ADV
ajst-392	133	29	trigger	trigger	VERB
ajst-392	133	30	chronic	chronic	ADJ
ajst-392	133	31	inflammation	inflammation	NOUN
ajst-392	133	32	,	,	PUNCT
ajst-392	133	33	and	and	CCONJ
ajst-392	133	34	eventually	eventually	ADV
ajst-392	133	35	develop	develop	VERB
ajst-392	133	36	into	into	ADP
ajst-392	133	37	inflammatory	inflammatory	ADJ
ajst-392	133	38	diseases	disease	NOUN
ajst-392	133	39	[	[	X
ajst-392	133	40	2	2	NUM
ajst-392	133	41	]	]	PUNCT
ajst-392	133	42	.	.	PUNCT
ajst-392	134	1	the	the	DET
ajst-392	134	2	m1	m1	PROPN
ajst-392	134	3	polarization	polarization	NOUN
ajst-392	134	4	of	of	ADP
ajst-392	134	5	macrophages	macrophage	NOUN
ajst-392	134	6	is	be	AUX
ajst-392	134	7	an	an	DET
ajst-392	134	8	important	important	ADJ
ajst-392	134	9	cause	cause	NOUN
ajst-392	134	10	of	of	ADP
ajst-392	134	11	many	many	ADJ
ajst-392	134	12	inflammatory	inflammatory	ADJ
ajst-392	134	13	diseases	disease	NOUN
ajst-392	134	14	,	,	PUNCT
ajst-392	134	15	so	so	ADV
ajst-392	134	16	inhibiting	inhibit	VERB
ajst-392	134	17	the	the	DET
ajst-392	134	18	m1	m1	PROPN
ajst-392	134	19	polarization	polarization	NOUN
ajst-392	134	20	of	of	ADP
ajst-392	134	21	macrophages	macrophage	NOUN
ajst-392	134	22	and	and	CCONJ
ajst-392	134	23	reducing	reduce	VERB
ajst-392	134	24	the	the	DET
ajst-392	134	25	inflammatory	inflammatory	ADJ
ajst-392	134	26	response	response	NOUN
ajst-392	134	27	is	be	AUX
ajst-392	134	28	a	a	DET
ajst-392	134	29	potential	potential	ADJ
ajst-392	134	30	strategy	strategy	NOUN
ajst-392	134	31	for	for	ADP
ajst-392	134	32	the	the	DET
ajst-392	134	33	treatment	treatment	NOUN
ajst-392	134	34	of	of	ADP
ajst-392	134	35	inflammatory	inflammatory	ADJ
ajst-392	134	36	diseases	disease	NOUN
ajst-392	134	37	.	.	PUNCT
ajst-392	135	1	lps	lps	PROPN
ajst-392	135	2	can	can	AUX
ajst-392	135	3	induce	induce	VERB
ajst-392	135	4	m1	m1	NOUN
ajst-392	135	5	polarization	polarization	NOUN
ajst-392	135	6	of	of	ADP
ajst-392	135	7	macrophages	macrophage	NOUN
ajst-392	135	8	,	,	PUNCT
ajst-392	135	9	up	up	ADV
ajst-392	135	10	-	-	PUNCT
ajst-392	135	11	regulate	regulate	VERB
ajst-392	135	12	the	the	DET
ajst-392	135	13	expression	expression	NOUN
ajst-392	135	14	of	of	ADP
ajst-392	135	15	inflammatory	inflammatory	ADJ
ajst-392	135	16	mediators	mediator	NOUN
ajst-392	135	17	such	such	ADJ
ajst-392	135	18	as	as	ADP
ajst-392	135	19	tnf	tnf	PROPN
ajst-392	135	20	-	-	PUNCT
ajst-392	135	21	α	α	PROPN
ajst-392	135	22	,	,	PUNCT
ajst-392	135	23	il-6	il-6	NUM
ajst-392	135	24	,	,	PUNCT
ajst-392	135	25	no	no	INTJ
ajst-392	135	26	,	,	PUNCT
ajst-392	135	27	etc	etc	X
ajst-392	135	28	.	.	X
ajst-392	135	29	,	,	PUNCT
ajst-392	135	30	triggering	trigger	VERB
ajst-392	135	31	a	a	DET
ajst-392	135	32	significant	significant	ADJ
ajst-392	135	33	inflammatory	inflammatory	ADJ
ajst-392	135	34	response	response	NOUN
ajst-392	135	35	[	[	X
ajst-392	135	36	23	23	NUM
ajst-392	135	37	]	]	PUNCT
ajst-392	135	38	,	,	PUNCT
ajst-392	135	39	and	and	CCONJ
ajst-392	135	40	proinflammatory	proinflammatory	ADJ
ajst-392	135	41	mediators	mediator	NOUN
ajst-392	135	42	can	can	AUX
ajst-392	135	43	further	far	ADV
ajst-392	135	44	promote	promote	VERB
ajst-392	135	45	tlr4	tlr4	NOUN
ajst-392	135	46	signaling	signal	VERB
ajst-392	135	47	and	and	CCONJ
ajst-392	135	48	aggravate	aggravate	VERB
ajst-392	135	49	the	the	DET
ajst-392	135	50	inflammatory	inflammatory	ADJ
ajst-392	135	51	response	response	NOUN
ajst-392	135	52	.	.	PUNCT
ajst-392	136	1	pituitary	pituitary	ADJ
ajst-392	136	2	adenylate	adenylate	ADJ
ajst-392	136	3	cyclase	cyclase	NOUN
ajst-392	136	4	-	-	PUNCT
ajst-392	136	5	activating	activate	VERB
ajst-392	136	6	polypeptide	polypeptide	ADJ
ajst-392	136	7	(	(	PUNCT
ajst-392	136	8	pacap	pacap	NOUN
ajst-392	136	9	)	)	PUNCT
ajst-392	136	10	is	be	AUX
ajst-392	136	11	a	a	DET
ajst-392	136	12	neuropeptide	neuropeptide	NOUN
ajst-392	136	13	with	with	ADP
ajst-392	136	14	good	good	ADJ
ajst-392	136	15	anti	anti	ADJ
ajst-392	136	16	-	-	ADJ
ajst-392	136	17	inflammatory	inflammatory	ADJ
ajst-392	136	18	effect	effect	NOUN
ajst-392	136	19	,	,	PUNCT
ajst-392	136	20	widely	widely	ADV
ajst-392	136	21	expressed	express	VERB
ajst-392	136	22	in	in	ADP
ajst-392	136	23	mammals	mammal	NOUN
ajst-392	136	24	,	,	PUNCT
ajst-392	136	25	and	and	CCONJ
ajst-392	136	26	its	its	PRON
ajst-392	136	27	amino	amino	NOUN
ajst-392	136	28	acid	acid	NOUN
ajst-392	136	29	sequence	sequence	NOUN
ajst-392	136	30	is	be	AUX
ajst-392	136	31	still	still	ADV
ajst-392	136	32	highly	highly	ADV
ajst-392	136	33	conserved	conserved	ADJ
ajst-392	136	34	in	in	ADP
ajst-392	136	35	long	long	ADJ
ajst-392	136	36	-	-	PUNCT
ajst-392	136	37	term	term	NOUN
ajst-392	136	38	evolution	evolution	NOUN
ajst-392	137	1	[	[	X
ajst-392	137	2	24–26	24–26	NUM
ajst-392	137	3	]	]	PUNCT
ajst-392	137	4	.	.	PUNCT
ajst-392	138	1	the	the	DET
ajst-392	138	2	previous	previous	ADJ
ajst-392	138	3	study	study	NOUN
ajst-392	138	4	of	of	ADP
ajst-392	138	5	our	our	PRON
ajst-392	138	6	group	group	NOUN
ajst-392	138	7	showed	show	VERB
ajst-392	138	8	that	that	SCONJ
ajst-392	138	9	exogenous	exogenous	ADJ
ajst-392	138	10	administration	administration	NOUN
ajst-392	138	11	of	of	ADP
ajst-392	138	12	pacap	pacap	NOUN
ajst-392	138	13	could	could	AUX
ajst-392	138	14	inhibit	inhibit	VERB
ajst-392	138	15	the	the	DET
ajst-392	138	16	inflammatory	inflammatory	ADJ
ajst-392	138	17	response	response	NOUN
ajst-392	138	18	in	in	ADP
ajst-392	138	19	mouse	mouse	NOUN
ajst-392	138	20	gc-2	gc-2	PART
ajst-392	138	21	cells	cell	NOUN
ajst-392	138	22	induced	induce	VERB
ajst-392	138	23	by	by	ADP
ajst-392	138	24	palmitic	palmitic	ADJ
ajst-392	138	25	acid	acid	NOUN
ajst-392	138	26	(	(	PUNCT
ajst-392	138	27	pa	pa	PROPN
ajst-392	138	28	)	)	PUNCT
ajst-392	138	29	,	,	PUNCT
ajst-392	138	30	and	and	CCONJ
ajst-392	138	31	showed	show	VERB
ajst-392	138	32	a	a	DET
ajst-392	138	33	significant	significant	ADJ
ajst-392	138	34	inhibitory	inhibitory	ADJ
ajst-392	138	35	effect	effect	NOUN
ajst-392	138	36	on	on	ADP
ajst-392	138	37	inflammatory	inflammatory	ADJ
ajst-392	138	38	factors	factor	NOUN
ajst-392	138	39	such	such	ADJ
ajst-392	138	40	as	as	ADP
ajst-392	138	41	tnf	tnf	PROPN
ajst-392	138	42	-	-	PUNCT
ajst-392	138	43	α	α	PROPN
ajst-392	138	44	and	and	CCONJ
ajst-392	138	45	il-6	il-6	NOUN
ajst-392	138	46	,	,	PUNCT
ajst-392	138	47	improved	improve	VERB
ajst-392	138	48	the	the	DET
ajst-392	138	49	reproductive	reproductive	ADJ
ajst-392	138	50	impairment	impairment	NOUN
ajst-392	138	51	of	of	ADP
ajst-392	138	52	obese	obese	ADJ
ajst-392	138	53	mice	mouse	NOUN
ajst-392	138	54	;	;	PUNCT
ajst-392	138	55	in	in	ADP
ajst-392	138	56	addition	addition	NOUN
ajst-392	138	57	,	,	PUNCT
ajst-392	138	58	pacap	pacap	NOUN
ajst-392	138	59	could	could	AUX
ajst-392	138	60	improve	improve	VERB
ajst-392	138	61	insulin	insulin	NOUN
ajst-392	138	62	resistance	resistance	NOUN
ajst-392	138	63	and	and	CCONJ
ajst-392	138	64	reduce	reduce	VERB
ajst-392	138	65	the	the	DET
ajst-392	138	66	levels	level	NOUN
ajst-392	138	67	of	of	ADP
ajst-392	138	68	inflammatory	inflammatory	ADJ
ajst-392	138	69	factors	factor	NOUN
ajst-392	138	70	in	in	ADP
ajst-392	138	71	mouse	mouse	NOUN
ajst-392	138	72	tissue	tissue	NOUN
ajst-392	138	73	in	in	ADP
ajst-392	138	74	obese	obese	ADJ
ajst-392	138	75	mice	mouse	NOUN
ajst-392	138	76	fed	feed	VERB
ajst-392	138	77	with	with	ADP
ajst-392	138	78	high	high	ADJ
ajst-392	138	79	-	-	PUNCT
ajst-392	138	80	fat	fat	NOUN
ajst-392	138	81	diet	diet	NOUN
ajst-392	138	82	.	.	PUNCT
ajst-392	139	1	our	our	PRON
ajst-392	139	2	study	study	NOUN
ajst-392	139	3	found	find	VERB
ajst-392	139	4	that	that	SCONJ
ajst-392	139	5	0.1	0.1	NUM
ajst-392	139	6	μm	μm	NOUN
ajst-392	139	7	pacap	pacap	NOUN
ajst-392	139	8	treatment	treatment	NOUN
ajst-392	139	9	can	can	AUX
ajst-392	139	10	significantly	significantly	ADV
ajst-392	139	11	inhibit	inhibit	VERB
ajst-392	139	12	the	the	DET
ajst-392	139	13	transcription	transcription	NOUN
ajst-392	139	14	level	level	NOUN
ajst-392	139	15	of	of	ADP
ajst-392	139	16	lps	lps	PROPN
ajst-392	139	17	-	-	PUNCT
ajst-392	139	18	induced	induce	VERB
ajst-392	139	19	macrophage	macrophage	ADJ
ajst-392	139	20	m1	m1	PROPN
ajst-392	139	21	polarization	polarization	NOUN
ajst-392	139	22	markers	marker	VERB
ajst-392	139	23	tnf	tnf	PROPN
ajst-392	139	24	-	-	PUNCT
ajst-392	139	25	α	α	PROPN
ajst-392	139	26	and	and	CCONJ
ajst-392	139	27	nos2	nos2	PROPN
ajst-392	139	28	gene	gene	NOUN
ajst-392	139	29	,	,	PUNCT
ajst-392	139	30	significantly	significantly	ADV
ajst-392	139	31	down	down	ADV
ajst-392	139	32	-	-	PUNCT
ajst-392	139	33	regulate	regulate	VERB
ajst-392	139	34	the	the	DET
ajst-392	139	35	expression	expression	NOUN
ajst-392	139	36	of	of	ADP
ajst-392	139	37	inflammatory	inflammatory	ADJ
ajst-392	139	38	factors	factor	NOUN
ajst-392	139	39	such	such	ADJ
ajst-392	139	40	as	as	ADP
ajst-392	139	41	il-6	il-6	NUM
ajst-392	139	42	,	,	PUNCT
ajst-392	139	43	il-1β	il-1β	PROPN
ajst-392	139	44	,	,	PUNCT
ajst-392	139	45	mcp-1	mcp-1	NOUN
ajst-392	139	46	,	,	PUNCT
ajst-392	139	47	and	and	CCONJ
ajst-392	139	48	tnf	tnf	PROPN
ajst-392	139	49	-	-	PUNCT
ajst-392	139	50	α	α	PROPN
ajst-392	139	51	(	(	PUNCT
ajst-392	139	52	fig	fig	NOUN
ajst-392	139	53	3).the	3).the	DET
ajst-392	139	54	above	above	ADJ
ajst-392	139	55	results	result	NOUN
ajst-392	139	56	were	be	AUX
ajst-392	139	57	consistent	consistent	ADJ
ajst-392	139	58	with	with	ADP
ajst-392	139	59	the	the	DET
ajst-392	139	60	ones	one	NOUN
ajst-392	139	61	our	our	PRON
ajst-392	139	62	group	group	NOUN
ajst-392	139	63	previously	previously	ADV
ajst-392	139	64	found	find	VERB
ajst-392	139	65	,	,	PUNCT
ajst-392	139	66	confirming	confirm	VERB
ajst-392	139	67	that	that	SCONJ
ajst-392	139	68	pacap	pacap	NOUN
ajst-392	139	69	has	have	VERB
ajst-392	139	70	significant	significant	ADJ
ajst-392	139	71	anti	anti	ADJ
ajst-392	139	72	-	-	ADJ
ajst-392	139	73	inflammatory	inflammatory	ADJ
ajst-392	139	74	activity	activity	NOUN
ajst-392	139	75	.	.	PUNCT
ajst-392	140	1	then	then	ADV
ajst-392	140	2	,	,	PUNCT
ajst-392	140	3	the	the	DET
ajst-392	140	4	mechanism	mechanism	NOUN
ajst-392	140	5	of	of	ADP
ajst-392	140	6	pacap	pacap	NOUN
ajst-392	140	7	in	in	ADP
ajst-392	140	8	inhibiting	inhibit	VERB
ajst-392	140	9	m1	m1	NOUN
ajst-392	140	10	polarization	polarization	NOUN
ajst-392	140	11	and	and	CCONJ
ajst-392	140	12	inflammatory	inflammatory	ADJ
ajst-392	140	13	response	response	NOUN
ajst-392	140	14	was	be	AUX
ajst-392	140	15	further	far	ADV
ajst-392	140	16	explored	explore	VERB
ajst-392	140	17	.	.	PUNCT
ajst-392	141	1	pacap	pacap	VERB
ajst-392	141	2	receptor	receptor	NOUN
ajst-392	141	3	-	-	PUNCT
ajst-392	141	4	specific	specific	ADJ
ajst-392	141	5	inhibitors	inhibitor	NOUN
ajst-392	141	6	were	be	AUX
ajst-392	141	7	used	use	VERB
ajst-392	141	8	to	to	PART
ajst-392	141	9	block	block	VERB
ajst-392	141	10	receptor	receptor	NOUN
ajst-392	141	11	function	function	NOUN
ajst-392	141	12	to	to	PART
ajst-392	141	13	identify	identify	VERB
ajst-392	141	14	the	the	DET
ajst-392	141	15	type	type	NOUN
ajst-392	141	16	of	of	ADP
ajst-392	141	17	receptor	receptor	NOUN
ajst-392	141	18	that	that	PRON
ajst-392	141	19	pacap	pacap	NOUN
ajst-392	141	20	exerts	exert	VERB
ajst-392	141	21	anti	anti	ADJ
ajst-392	141	22	-	-	ADJ
ajst-392	141	23	inflammatory	inflammatory	ADJ
ajst-392	141	24	effects	effect	NOUN
ajst-392	141	25	in	in	ADP
ajst-392	141	26	raw264.7	raw264.7	NOUN
ajst-392	141	27	cells	cell	NOUN
ajst-392	141	28	.	.	PUNCT
ajst-392	142	1	the	the	DET
ajst-392	142	2	experimental	experimental	ADJ
ajst-392	142	3	results	result	NOUN
ajst-392	142	4	showed	show	VERB
ajst-392	142	5	that	that	SCONJ
ajst-392	142	6	after	after	ADP
ajst-392	142	7	the	the	DET
ajst-392	142	8	addition	addition	NOUN
ajst-392	142	9	of	of	ADP
ajst-392	142	10	max.d4	max.d4	NOUN
ajst-392	142	11	,	,	PUNCT
ajst-392	142	12	the	the	DET
ajst-392	142	13	pac1	pac1	NOUN
ajst-392	142	14	receptor	receptor	NOUN
ajst-392	142	15	was	be	AUX
ajst-392	142	16	specifically	specifically	ADV
ajst-392	142	17	bound	bind	VERB
ajst-392	142	18	,	,	PUNCT
ajst-392	142	19	so	so	SCONJ
ajst-392	142	20	that	that	DET
ajst-392	142	21	pacap	pacap	NOUN
ajst-392	142	22	could	could	AUX
ajst-392	142	23	no	no	ADV
ajst-392	142	24	longer	long	ADV
ajst-392	142	25	bind	bind	VERB
ajst-392	142	26	to	to	ADP
ajst-392	142	27	the	the	DET
ajst-392	142	28	receptor	receptor	NOUN
ajst-392	142	29	,	,	PUNCT
ajst-392	142	30	blocking	block	VERB
ajst-392	142	31	the	the	DET
ajst-392	142	32	signal	signal	ADJ
ajst-392	142	33	transduction	transduction	NOUN
ajst-392	142	34	of	of	ADP
ajst-392	142	35	pacap	pacap	NOUN
ajst-392	142	36	,	,	PUNCT
ajst-392	142	37	its	its	PRON
ajst-392	142	38	inhibitory	inhibitory	ADJ
ajst-392	142	39	effect	effect	NOUN
ajst-392	142	40	on	on	ADP
ajst-392	142	41	lpsinduced	lpsinduced	ADJ
ajst-392	142	42	expression	expression	NOUN
ajst-392	142	43	of	of	ADP
ajst-392	142	44	inflammatory	inflammatory	ADJ
ajst-392	142	45	genes	gene	NOUN
ajst-392	142	46	and	and	CCONJ
ajst-392	142	47	inflammatory	inflammatory	ADJ
ajst-392	142	48	factors	factor	NOUN
ajst-392	142	49	was	be	AUX
ajst-392	142	50	abolished(fig	abolished(fig	PROPN
ajst-392	142	51	4b	4b	PROPN
ajst-392	142	52	)	)	PUNCT
ajst-392	142	53	.	.	PUNCT
ajst-392	143	1	this	this	PRON
ajst-392	143	2	suggests	suggest	VERB
ajst-392	143	3	that	that	SCONJ
ajst-392	143	4	pacap	pacap	NOUN
ajst-392	143	5	inhibits	inhibit	VERB
ajst-392	143	6	m1	m1	PROPN
ajst-392	143	7	polarization	polarization	NOUN
ajst-392	143	8	of	of	ADP
ajst-392	143	9	macrophages	macrophage	NOUN
ajst-392	143	10	by	by	ADP
ajst-392	143	11	specifically	specifically	ADV
ajst-392	143	12	activating	activate	VERB
ajst-392	143	13	pac1	pac1	NOUN
ajst-392	143	14	receptors	receptor	NOUN
ajst-392	143	15	and	and	CCONJ
ajst-392	143	16	improves	improve	VERB
ajst-392	143	17	the	the	DET
ajst-392	143	18	inflammatory	inflammatory	ADJ
ajst-392	143	19	response	response	NOUN
ajst-392	143	20	.	.	PUNCT
ajst-392	144	1	studies	study	NOUN
ajst-392	144	2	have	have	AUX
ajst-392	144	3	shown	show	VERB
ajst-392	144	4	that	that	SCONJ
ajst-392	144	5	the	the	DET
ajst-392	144	6	activation	activation	NOUN
ajst-392	144	7	of	of	ADP
ajst-392	144	8	nf	nf	NOUN
ajst-392	144	9	-	-	PUNCT
ajst-392	144	10	κb	κb	NOUN
ajst-392	144	11	and	and	CCONJ
ajst-392	144	12	mapks	mapks	NOUN
ajst-392	144	13	pathways	pathway	NOUN
ajst-392	144	14	are	be	AUX
ajst-392	144	15	both	both	PRON
ajst-392	144	16	key	key	ADJ
ajst-392	144	17	events	event	NOUN
ajst-392	144	18	in	in	ADP
ajst-392	144	19	the	the	DET
ajst-392	144	20	inflammatory	inflammatory	ADJ
ajst-392	144	21	response	response	NOUN
ajst-392	144	22	,	,	PUNCT
ajst-392	144	23	and	and	CCONJ
ajst-392	144	24	they	they	PRON
ajst-392	144	25	play	play	VERB
ajst-392	144	26	a	a	DET
ajst-392	144	27	key	key	ADJ
ajst-392	144	28	role	role	NOUN
ajst-392	144	29	in	in	ADP
ajst-392	144	30	the	the	DET
ajst-392	144	31	regulation	regulation	NOUN
ajst-392	144	32	of	of	ADP
ajst-392	144	33	macrophage	macrophage	ADJ
ajst-392	144	34	behavior	behavior	NOUN
ajst-392	144	35	and	and	CCONJ
ajst-392	144	36	amplifying	amplify	VERB
ajst-392	144	37	inflammatory	inflammatory	ADJ
ajst-392	144	38	signals	signal	NOUN
ajst-392	144	39	[	[	X
ajst-392	144	40	27	27	NUM
ajst-392	144	41	]	]	PUNCT
ajst-392	144	42	.	.	PUNCT
ajst-392	145	1	interfering	interfere	VERB
ajst-392	145	2	with	with	ADP
ajst-392	145	3	nf	nf	ADJ
ajst-392	145	4	-	-	PUNCT
ajst-392	145	5	κb	κb	NOUN
ajst-392	145	6	and	and	CCONJ
ajst-392	145	7	mapks	mapks	NOUN
ajst-392	145	8	pathways	pathway	NOUN
ajst-392	145	9	can	can	AUX
ajst-392	145	10	improve	improve	VERB
ajst-392	145	11	inflammation	inflammation	NOUN
ajst-392	145	12	to	to	ADP
ajst-392	145	13	varying	vary	VERB
ajst-392	145	14	degrees	degree	NOUN
ajst-392	145	15	[	[	X
ajst-392	145	16	28	28	NUM
ajst-392	145	17	,	,	PUNCT
ajst-392	145	18	29	29	NUM
ajst-392	145	19	]	]	PUNCT
ajst-392	145	20	.	.	PUNCT
ajst-392	146	1	therefore	therefore	ADV
ajst-392	146	2	,	,	PUNCT
ajst-392	146	3	we	we	PRON
ajst-392	146	4	further	far	ADV
ajst-392	146	5	explored	explore	VERB
ajst-392	146	6	the	the	DET
ajst-392	146	7	effect	effect	NOUN
ajst-392	146	8	of	of	ADP
ajst-392	146	9	pacap	pacap	NOUN
ajst-392	146	10	on	on	ADP
ajst-392	146	11	the	the	DET
ajst-392	146	12	signaling	signaling	NOUN
ajst-392	146	13	of	of	ADP
ajst-392	146	14	nf	nf	NOUN
ajst-392	146	15	-	-	PUNCT
ajst-392	146	16	κb	κb	NOUN
ajst-392	146	17	and	and	CCONJ
ajst-392	146	18	mapks	mapks	NOUN
ajst-392	146	19	pathways	pathway	NOUN
ajst-392	146	20	in	in	ADP
ajst-392	146	21	the	the	DET
ajst-392	146	22	inflammatory	inflammatory	ADJ
ajst-392	146	23	response	response	NOUN
ajst-392	146	24	.	.	PUNCT
ajst-392	147	1	the	the	DET
ajst-392	147	2	results	result	NOUN
ajst-392	147	3	showed	show	VERB
ajst-392	147	4	that	that	SCONJ
ajst-392	147	5	pacap	pacap	NOUN
ajst-392	147	6	could	could	AUX
ajst-392	147	7	significantly	significantly	ADV
ajst-392	147	8	downregulate	downregulate	VERB
ajst-392	147	9	the	the	DET
ajst-392	147	10	expression	expression	NOUN
ajst-392	147	11	of	of	ADP
ajst-392	147	12	tlr4	tlr4	NOUN
ajst-392	147	13	and	and	CCONJ
ajst-392	147	14	the	the	DET
ajst-392	147	15	phosphorylation	phosphorylation	NOUN
ajst-392	147	16	of	of	ADP
ajst-392	147	17	ikk2	ikk2	PROPN
ajst-392	147	18	,	,	PUNCT
ajst-392	147	19	iκbα	iκbα	ADV
ajst-392	147	20	,	,	PUNCT
ajst-392	147	21	and	and	CCONJ
ajst-392	147	22	nf	nf	X
ajst-392	147	23	-	-	PUNCT
ajst-392	147	24	κb	κb	NOUN
ajst-392	147	25	(	(	PUNCT
ajst-392	147	26	fig	fig	NOUN
ajst-392	147	27	.	.	PUNCT
ajst-392	148	1	5a	5a	NUM
ajst-392	148	2	)	)	PUNCT
ajst-392	148	3	.	.	PUNCT
ajst-392	149	1	similarly	similarly	ADV
ajst-392	149	2	,	,	PUNCT
ajst-392	149	3	studies	study	NOUN
ajst-392	149	4	have	have	AUX
ajst-392	149	5	shown	show	VERB
ajst-392	149	6	that	that	SCONJ
ajst-392	149	7	the	the	DET
ajst-392	149	8	activation	activation	NOUN
ajst-392	149	9	of	of	ADP
ajst-392	149	10	ikk	ikk	PROPN
ajst-392	149	11	and	and	CCONJ
ajst-392	149	12	nf	nf	NOUN
ajst-392	149	13	-	-	PUNCT
ajst-392	149	14	κb	κb	NOUN
ajst-392	149	15	in	in	ADP
ajst-392	149	16	obese	obese	ADJ
ajst-392	149	17	mice	mouse	NOUN
ajst-392	149	18	is	be	AUX
ajst-392	149	19	inhibited	inhibit	VERB
ajst-392	149	20	,	,	PUNCT
ajst-392	149	21	and	and	CCONJ
ajst-392	149	22	tissue	tissue	NOUN
ajst-392	149	23	inflammation	inflammation	NOUN
ajst-392	149	24	is	be	AUX
ajst-392	149	25	improved	improve	VERB
ajst-392	149	26	when	when	SCONJ
ajst-392	149	27	salicylic	salicylic	ADJ
ajst-392	149	28	acid	acid	NOUN
ajst-392	149	29	is	be	AUX
ajst-392	149	30	administered	administer	VERB
ajst-392	149	31	exogenously	exogenously	ADV
ajst-392	149	32	[	[	X
ajst-392	149	33	30	30	NUM
ajst-392	149	34	]	]	PUNCT
ajst-392	149	35	.	.	PUNCT
ajst-392	150	1	the	the	DET
ajst-392	150	2	phosphorylation	phosphorylation	NOUN
ajst-392	150	3	of	of	ADP
ajst-392	150	4	jnk	jnk	PROPN
ajst-392	150	5	,	,	PUNCT
ajst-392	150	6	p38	p38	NOUN
ajst-392	150	7	and	and	CCONJ
ajst-392	150	8	erk	erk	PROPN
ajst-392	150	9	was	be	AUX
ajst-392	150	10	strongly	strongly	ADV
ajst-392	150	11	induced	induce	VERB
ajst-392	150	12	by	by	ADP
ajst-392	150	13	lps	lps	PROPN
ajst-392	150	14	in	in	ADP
ajst-392	150	15	raw264.7	raw264.7	PROPN
ajst-392	150	16	cells	cell	NOUN
ajst-392	150	17	,	,	PUNCT
ajst-392	150	18	which	which	PRON
ajst-392	150	19	was	be	AUX
ajst-392	150	20	consistent	consistent	ADJ
ajst-392	150	21	with	with	ADP
ajst-392	150	22	the	the	DET
ajst-392	150	23	mainstream	mainstream	NOUN
ajst-392	150	24	research	research	NOUN
ajst-392	150	25	results	result	NOUN
ajst-392	150	26	.	.	PUNCT
ajst-392	151	1	pacap	pacap	NOUN
ajst-392	151	2	can	can	AUX
ajst-392	151	3	inhibit	inhibit	VERB
ajst-392	151	4	the	the	DET
ajst-392	151	5	phosphorylation	phosphorylation	NOUN
ajst-392	151	6	of	of	ADP
ajst-392	151	7	jnk	jnk	PROPN
ajst-392	151	8	and	and	CCONJ
ajst-392	151	9	p38	p38	NOUN
ajst-392	151	10	,	,	PUNCT
ajst-392	151	11	but	but	CCONJ
ajst-392	151	12	has	have	VERB
ajst-392	151	13	no	no	DET
ajst-392	151	14	inhibitory	inhibitory	ADJ
ajst-392	151	15	effect	effect	NOUN
ajst-392	151	16	on	on	ADP
ajst-392	151	17	the	the	DET
ajst-392	151	18	phosphorylation	phosphorylation	NOUN
ajst-392	151	19	of	of	ADP
ajst-392	151	20	erk	erk	PROPN
ajst-392	151	21	,	,	PUNCT
ajst-392	151	22	which	which	PRON
ajst-392	151	23	is	be	AUX
ajst-392	151	24	consistent	consistent	ADJ
ajst-392	151	25	with	with	ADP
ajst-392	151	26	the	the	DET
ajst-392	151	27	results	result	NOUN
ajst-392	151	28	of	of	ADP
ajst-392	151	29	dziarski	dziarski	NOUN
ajst-392	152	1	[	[	X
ajst-392	152	2	31	31	NUM
ajst-392	152	3	]	]	PUNCT
ajst-392	152	4	.	.	PUNCT
ajst-392	153	1	it	it	PRON
ajst-392	153	2	indicated	indicate	VERB
ajst-392	153	3	that	that	SCONJ
ajst-392	153	4	pacap	pacap	NOUN
ajst-392	153	5	exerts	exert	VERB
ajst-392	153	6	antiinflammatory	antiinflammatory	NOUN
ajst-392	153	7	effect	effect	NOUN
ajst-392	153	8	by	by	ADP
ajst-392	153	9	selectively	selectively	ADV
ajst-392	153	10	inhibiting	inhibit	VERB
ajst-392	153	11	jnk	jnk	NOUN
ajst-392	153	12	and	and	CCONJ
ajst-392	153	13	p38	p38	NOUN
ajst-392	153	14	.	.	PUNCT
ajst-392	154	1	pacap	pacap	NOUN
ajst-392	154	2	can	can	AUX
ajst-392	154	3	trigger	trigger	VERB
ajst-392	154	4	a	a	DET
ajst-392	154	5	dramatic	dramatic	ADJ
ajst-392	154	6	increase	increase	NOUN
ajst-392	154	7	in	in	ADP
ajst-392	154	8	camp	camp	NOUN
ajst-392	154	9	levels	level	NOUN
ajst-392	154	10	.	.	PUNCT
ajst-392	155	1	studies	study	NOUN
ajst-392	155	2	have	have	AUX
ajst-392	155	3	shown	show	VERB
ajst-392	155	4	that	that	SCONJ
ajst-392	155	5	the	the	DET
ajst-392	155	6	increase	increase	NOUN
ajst-392	155	7	of	of	ADP
ajst-392	155	8	camp	camp	NOUN
ajst-392	155	9	level	level	NOUN
ajst-392	155	10	has	have	VERB
ajst-392	155	11	an	an	DET
ajst-392	155	12	important	important	ADJ
ajst-392	155	13	effect	effect	NOUN
ajst-392	155	14	on	on	ADP
ajst-392	155	15	regulating	regulate	VERB
ajst-392	155	16	the	the	DET
ajst-392	155	17	expression	expression	NOUN
ajst-392	155	18	of	of	ADP
ajst-392	155	19	inos	ino	NOUN
ajst-392	155	20	and	and	CCONJ
ajst-392	155	21	its	its	PRON
ajst-392	155	22	product	product	NOUN
ajst-392	155	23	no	no	ADV
ajst-392	155	24	in	in	ADP
ajst-392	155	25	mouse	mouse	NOUN
ajst-392	155	26	macrophages	macrophage	NOUN
ajst-392	155	27	[	[	X
ajst-392	155	28	32	32	NUM
ajst-392	155	29	,	,	PUNCT
ajst-392	155	30	33	33	NUM
ajst-392	155	31	]	]	PUNCT
ajst-392	155	32	.	.	PUNCT
ajst-392	156	1	therefore	therefore	ADV
ajst-392	156	2	,	,	PUNCT
ajst-392	156	3	in	in	ADP
ajst-392	156	4	order	order	NOUN
ajst-392	156	5	to	to	PART
ajst-392	156	6	clarify	clarify	VERB
ajst-392	156	7	the	the	DET
ajst-392	156	8	pathway	pathway	NOUN
ajst-392	156	9	by	by	ADP
ajst-392	156	10	which	which	PRON
ajst-392	156	11	the	the	DET
ajst-392	156	12	downstream	downstream	ADJ
ajst-392	156	13	components	component	NOUN
ajst-392	156	14	of	of	ADP
ajst-392	156	15	pacap	pacap	PROPN
ajst-392	156	16	inhibit	inhibit	VERB
ajst-392	156	17	nf	nf	PROPN
ajst-392	156	18	-	-	PUNCT
ajst-392	156	19	κb	κb	NOUN
ajst-392	156	20	and	and	CCONJ
ajst-392	156	21	mapks	mapks	NOUN
ajst-392	156	22	,	,	PUNCT
ajst-392	156	23	we	we	PRON
ajst-392	156	24	pretreated	pretreate	VERB
ajst-392	156	25	the	the	DET
ajst-392	156	26	cells	cell	NOUN
ajst-392	156	27	with	with	ADP
ajst-392	156	28	the	the	DET
ajst-392	156	29	camp	camp	NOUN
ajst-392	156	30	/	/	SYM
ajst-392	156	31	pka	pka	NOUN
ajst-392	156	32	-	-	PUNCT
ajst-392	156	33	specific	specific	ADJ
ajst-392	156	34	pathway	pathway	NOUN
ajst-392	156	35	inhibitor	inhibitor	NOUN
ajst-392	156	36	h89	h89	PROPN
ajst-392	156	37	.	.	PUNCT
ajst-392	157	1	the	the	DET
ajst-392	157	2	results	result	NOUN
ajst-392	157	3	showed	show	VERB
ajst-392	157	4	that	that	SCONJ
ajst-392	157	5	the	the	DET
ajst-392	157	6	inhibitory	inhibitory	ADJ
ajst-392	157	7	effect	effect	NOUN
ajst-392	157	8	of	of	ADP
ajst-392	157	9	pacap	pacap	NOUN
ajst-392	157	10	on	on	ADP
ajst-392	157	11	nf	nf	NOUN
ajst-392	157	12	-	-	PUNCT
ajst-392	157	13	κb	κb	NOUN
ajst-392	157	14	and	and	CCONJ
ajst-392	157	15	mapks	mapks	NOUN
ajst-392	157	16	signaling	signal	VERB
ajst-392	157	17	pathway	pathway	NOUN
ajst-392	157	18	was	be	AUX
ajst-392	157	19	affected	affect	VERB
ajst-392	157	20	attenuated	attenuate	VERB
ajst-392	157	21	,	,	PUNCT
ajst-392	157	22	indicating	indicate	VERB
ajst-392	157	23	that	that	SCONJ
ajst-392	157	24	pacap	pacap	NOUN
ajst-392	157	25	acts	act	VERB
ajst-392	157	26	on	on	ADP
ajst-392	157	27	raw264.7	raw264.7	NOUN
ajst-392	157	28	macrophages	macrophage	NOUN
ajst-392	157	29	by	by	ADP
ajst-392	157	30	activating	activate	VERB
ajst-392	157	31	the	the	DET
ajst-392	157	32	pac1	pac1	NOUN
ajst-392	157	33	/	/	SYM
ajst-392	157	34	camp	camp	NOUN
ajst-392	157	35	/	/	SYM
ajst-392	157	36	pka	pka	NOUN
ajst-392	157	37	pathway	pathway	NOUN
ajst-392	157	38	to	to	PART
ajst-392	157	39	inhibit	inhibit	VERB
ajst-392	157	40	the	the	DET
ajst-392	157	41	nf	nf	NOUN
ajst-392	157	42	-	-	PUNCT
ajst-392	157	43	κb	κb	NOUN
ajst-392	157	44	and	and	CCONJ
ajst-392	157	45	mapks	mapks	NOUN
ajst-392	157	46	pathways	pathway	NOUN
ajst-392	157	47	,	,	PUNCT
ajst-392	157	48	thereby	thereby	ADV
ajst-392	157	49	inhibiting	inhibit	VERB
ajst-392	157	50	m1	m1	NOUN
ajst-392	157	51	polarization	polarization	NOUN
ajst-392	157	52	and	and	CCONJ
ajst-392	157	53	inflammation	inflammation	NOUN
ajst-392	157	54	.	.	PUNCT
ajst-392	158	1	fig	fig	NOUN
ajst-392	158	2	8	8	NUM
ajst-392	158	3	pacap	pacap	NOUN
ajst-392	158	4	inhibiting	inhibit	VERB
ajst-392	158	5	macrophage	macrophage	ADJ
ajst-392	158	6	m1	m1	NOUN
ajst-392	158	7	polarization	polarization	NOUN
ajst-392	158	8	and	and	CCONJ
ajst-392	158	9	inflammatory	inflammatory	ADJ
ajst-392	158	10	response	response	NOUN
ajst-392	158	11	by	by	ADP
ajst-392	158	12	regulating	regulate	VERB
ajst-392	158	13	the	the	DET
ajst-392	158	14	nf	nf	NOUN
ajst-392	158	15	-	-	PUNCT
ajst-392	158	16	κb	κb	NOUN
ajst-392	158	17	and	and	CCONJ
ajst-392	158	18	mapks	mapks	NOUN
ajst-392	158	19	signaling	signal	VERB
ajst-392	158	20	pathways	pathway	NOUN
ajst-392	158	21	.	.	PUNCT
ajst-392	159	1	18	18	NUM
ajst-392	159	2	5	5	NUM
ajst-392	159	3	.	.	PUNCT
ajst-392	159	4	conclusion	conclusion	NOUN
ajst-392	159	5	previously	previously	ADV
ajst-392	159	6	,	,	PUNCT
ajst-392	159	7	the	the	DET
ajst-392	159	8	anti	anti	ADJ
ajst-392	159	9	-	-	ADJ
ajst-392	159	10	inflammatory	inflammatory	ADJ
ajst-392	159	11	ability	ability	NOUN
ajst-392	159	12	of	of	ADP
ajst-392	159	13	pacap	pacap	NOUN
ajst-392	159	14	was	be	AUX
ajst-392	159	15	mostly	mostly	ADV
ajst-392	159	16	reported	report	VERB
ajst-392	159	17	in	in	ADP
ajst-392	159	18	hepatocytes	hepatocyte	NOUN
ajst-392	159	19	,	,	PUNCT
ajst-392	159	20	nerve	nerve	NOUN
ajst-392	159	21	cells	cell	NOUN
ajst-392	159	22	and	and	CCONJ
ajst-392	159	23	other	other	ADJ
ajst-392	159	24	cells	cell	NOUN
ajst-392	159	25	,	,	PUNCT
ajst-392	159	26	and	and	CCONJ
ajst-392	159	27	the	the	DET
ajst-392	159	28	anti	anti	ADJ
ajst-392	159	29	-	-	ADJ
ajst-392	159	30	inflammatory	inflammatory	ADJ
ajst-392	159	31	effect	effect	NOUN
ajst-392	159	32	and	and	CCONJ
ajst-392	159	33	mechanism	mechanism	NOUN
ajst-392	159	34	of	of	ADP
ajst-392	159	35	pacap	pacap	NOUN
ajst-392	159	36	in	in	ADP
ajst-392	159	37	lps	lps	PROPN
ajst-392	159	38	-	-	PUNCT
ajst-392	159	39	induced	induce	VERB
ajst-392	159	40	raw264.7	raw264.7	NOUN
ajst-392	159	41	cells	cell	NOUN
ajst-392	159	42	were	be	AUX
ajst-392	159	43	not	not	PART
ajst-392	159	44	clear	clear	ADJ
ajst-392	159	45	.	.	PUNCT
ajst-392	160	1	in	in	ADP
ajst-392	160	2	this	this	DET
ajst-392	160	3	study	study	NOUN
ajst-392	160	4	,	,	PUNCT
ajst-392	160	5	we	we	PRON
ajst-392	160	6	report	report	VERB
ajst-392	160	7	the	the	DET
ajst-392	160	8	anti	anti	ADJ
ajst-392	160	9	-	-	ADJ
ajst-392	160	10	inflammatory	inflammatory	ADJ
ajst-392	160	11	effect	effect	NOUN
ajst-392	160	12	and	and	CCONJ
ajst-392	160	13	possible	possible	ADJ
ajst-392	160	14	mechanism	mechanism	NOUN
ajst-392	160	15	of	of	ADP
ajst-392	160	16	pacap	pacap	NOUN
ajst-392	160	17	on	on	ADP
ajst-392	160	18	lps	lps	PROPN
ajst-392	160	19	-	-	PUNCT
ajst-392	160	20	induced	induce	VERB
ajst-392	160	21	m1	m1	NOUN
ajst-392	160	22	polarization	polarization	NOUN
ajst-392	160	23	and	and	CCONJ
ajst-392	160	24	inflammatory	inflammatory	ADJ
ajst-392	160	25	response	response	NOUN
ajst-392	160	26	in	in	ADP
ajst-392	160	27	raw264.7	raw264.7	NOUN
ajst-392	160	28	cells	cell	NOUN
ajst-392	160	29	.	.	PUNCT
ajst-392	161	1	as	as	ADP
ajst-392	161	2	a	a	DET
ajst-392	161	3	highly	highly	ADV
ajst-392	161	4	safe	safe	ADJ
ajst-392	161	5	neuropeptide	neuropeptide	NOUN
ajst-392	161	6	,	,	PUNCT
ajst-392	161	7	pacap	pacap	NOUN
ajst-392	161	8	can	can	AUX
ajst-392	161	9	target	target	VERB
ajst-392	161	10	key	key	ADJ
ajst-392	161	11	molecules	molecule	NOUN
ajst-392	161	12	of	of	ADP
ajst-392	161	13	the	the	DET
ajst-392	161	14	inflammatory	inflammatory	ADJ
ajst-392	161	15	pathway	pathway	NOUN
ajst-392	161	16	,	,	PUNCT
ajst-392	161	17	regulate	regulate	VERB
ajst-392	161	18	macrophage	macrophage	ADJ
ajst-392	161	19	m1	m1	NOUN
ajst-392	161	20	polarization	polarization	NOUN
ajst-392	161	21	and	and	CCONJ
ajst-392	161	22	inflammatory	inflammatory	ADJ
ajst-392	161	23	response	response	NOUN
ajst-392	161	24	,	,	PUNCT
ajst-392	161	25	and	and	CCONJ
ajst-392	161	26	provide	provide	VERB
ajst-392	161	27	an	an	DET
ajst-392	161	28	effective	effective	ADJ
ajst-392	161	29	strategy	strategy	NOUN
ajst-392	161	30	for	for	ADP
ajst-392	161	31	the	the	DET
ajst-392	161	32	treatment	treatment	NOUN
ajst-392	161	33	of	of	ADP
ajst-392	161	34	inflammatory	inflammatory	ADJ
ajst-392	161	35	diseases	disease	NOUN
ajst-392	161	36	and	and	CCONJ
ajst-392	161	37	the	the	DET
ajst-392	161	38	development	development	NOUN
ajst-392	161	39	of	of	ADP
ajst-392	161	40	new	new	ADJ
ajst-392	161	41	multi	multi	ADJ
ajst-392	161	42	-	-	ADJ
ajst-392	161	43	targeted	target	VERB
ajst-392	161	44	anti	anti	ADJ
ajst-392	161	45	-	-	ADJ
ajst-392	161	46	inflammatory	inflammatory	ADJ
ajst-392	161	47	drugs	drug	NOUN
ajst-392	161	48	.	.	PUNCT
ajst-392	162	1	acknowledgment	acknowledgment	NOUN
ajst-392	162	2	this	this	DET
ajst-392	162	3	study	study	NOUN
ajst-392	162	4	was	be	AUX
ajst-392	162	5	supported	support	VERB
ajst-392	162	6	by	by	ADP
ajst-392	162	7	the	the	DET
ajst-392	162	8	national	national	ADJ
ajst-392	162	9	natural	natural	PROPN
ajst-392	162	10	science	science	PROPN
ajst-392	162	11	foundation	foundation	PROPN
ajst-392	162	12	of	of	ADP
ajst-392	162	13	china	china	PROPN
ajst-392	162	14	(	(	PUNCT
ajst-392	162	15	no	no	INTJ
ajst-392	162	16	.	.	NOUN
ajst-392	162	17	82073748	82073748	NUM
ajst-392	162	18	and	and	CCONJ
ajst-392	162	19	81741130	81741130	NUM
ajst-392	162	20	)	)	PUNCT
ajst-392	162	21	;	;	PUNCT
ajst-392	162	22	the	the	DET
ajst-392	162	23	guang	guang	PROPN
ajst-392	162	24	-	-	PUNCT
ajst-392	162	25	dong	dong	PROPN
ajst-392	162	26	basic	basic	ADJ
ajst-392	162	27	and	and	CCONJ
ajst-392	162	28	applied	apply	VERB
ajst-392	162	29	basic	basic	ADJ
ajst-392	162	30	research	research	NOUN
ajst-392	162	31	foundation	foundation	NOUN
ajst-392	162	32	(	(	PUNCT
ajst-392	162	33	no	no	INTJ
ajst-392	162	34	.	.	PUNCT
ajst-392	163	1	2019a1515011866	2019a1515011866	NOUN
ajst-392	163	2	and	and	CCONJ
ajst-392	163	3	2021a1515010993	2021a1515010993	NUM
ajst-392	163	4	)	)	PUNCT
ajst-392	163	5	;	;	PUNCT
ajst-392	163	6	guangdong	guangdong	PROPN
ajst-392	163	7	science	science	PROPN
ajst-392	163	8	and	and	CCONJ
ajst-392	163	9	technology	technology	NOUN
ajst-392	163	10	innovation	innovation	NOUN
ajst-392	163	11	strategy	strategy	NOUN
ajst-392	163	12	special	special	ADJ
ajst-392	163	13	fund	fund	NOUN
ajst-392	163	14	(	(	PUNCT
ajst-392	163	15	international	international	ADJ
ajst-392	163	16	science	science	NOUN
ajst-392	163	17	and	and	CCONJ
ajst-392	163	18	technology	technology	NOUN
ajst-392	163	19	cooperation	cooperation	NOUN
ajst-392	163	20	projects	project	NOUN
ajst-392	163	21	,	,	PUNCT
ajst-392	163	22	no	no	INTJ
ajst-392	163	23	.	.	PUNCT
ajst-392	164	1	2021a0505030034	2021a0505030034	NUM
ajst-392	164	2	)	)	PUNCT
ajst-392	164	3	.	.	PUNCT
ajst-392	165	1	references	reference	NOUN
ajst-392	165	2	[	[	X
ajst-392	165	3	1	1	NUM
ajst-392	165	4	]	]	PUNCT
ajst-392	165	5	straub	straub	PROPN
ajst-392	165	6	s	s	PROPN
ajst-392	165	7	g	g	NOUN
ajst-392	165	8	,	,	PUNCT
ajst-392	165	9	sharp	sharp	ADJ
ajst-392	165	10	g	g	PROPN
ajst-392	165	11	w.	w.	PROPN
ajst-392	165	12	a	a	DET
ajst-392	165	13	wortmannin	wortmannin	NOUN
ajst-392	165	14	-	-	PUNCT
ajst-392	165	15	sensitive	sensitive	ADJ
ajst-392	165	16	signal	signal	NOUN
ajst-392	165	17	transduction	transduction	NOUN
ajst-392	165	18	pathway	pathway	NOUN
ajst-392	165	19	is	be	AUX
ajst-392	165	20	involved	involve	VERB
ajst-392	165	21	in	in	ADP
ajst-392	165	22	the	the	DET
ajst-392	165	23	stimulation	stimulation	NOUN
ajst-392	165	24	of	of	ADP
ajst-392	165	25	insulin	insulin	NOUN
ajst-392	165	26	release	release	NOUN
ajst-392	165	27	by	by	ADP
ajst-392	165	28	vasoactive	vasoactive	ADJ
ajst-392	165	29	intestinal	intestinal	ADJ
ajst-392	165	30	polypeptide	polypeptide	ADJ
ajst-392	165	31	and	and	CCONJ
ajst-392	165	32	pituitary	pituitary	ADJ
ajst-392	165	33	adenylate	adenylate	ADJ
ajst-392	165	34	cyclase	cyclase	NOUN
ajst-392	165	35	-	-	PUNCT
ajst-392	165	36	activating	activate	VERB
ajst-392	165	37	polypeptide[j	polypeptide[j	NOUN
ajst-392	165	38	]	]	PUNCT
ajst-392	165	39	.	.	PUNCT
ajst-392	166	1	j	j	PROPN
ajst-392	166	2	biol	biol	PROPN
ajst-392	166	3	chem	chem	NOUN
ajst-392	166	4	,	,	PUNCT
ajst-392	166	5	1996	1996	NUM
ajst-392	166	6	,	,	PUNCT
ajst-392	166	7	271(3	271(3	NUM
ajst-392	166	8	):	):	PUNCT
ajst-392	166	9	1660	1660	NUM
ajst-392	166	10	-	-	SYM
ajst-392	166	11	1668	1668	NUM
ajst-392	166	12	.	.	PUNCT
ajst-392	167	1	[	[	X
ajst-392	167	2	2	2	NUM
ajst-392	167	3	]	]	X
ajst-392	167	4	atri	atri	PROPN
ajst-392	167	5	c	c	PROPN
ajst-392	167	6	,	,	PUNCT
ajst-392	167	7	guerfali	guerfali	PROPN
ajst-392	167	8	f	f	PROPN
ajst-392	167	9	z	z	PROPN
ajst-392	167	10	,	,	PUNCT
ajst-392	167	11	laouini	laouini	PROPN
ajst-392	167	12	d.	d.	PROPN
ajst-392	167	13	role	role	NOUN
ajst-392	167	14	of	of	ADP
ajst-392	167	15	human	human	ADJ
ajst-392	167	16	macrophage	macrophage	ADJ
ajst-392	167	17	polarization	polarization	NOUN
ajst-392	167	18	in	in	ADP
ajst-392	167	19	inflammation	inflammation	NOUN
ajst-392	167	20	during	during	ADP
ajst-392	167	21	infectious	infectious	ADJ
ajst-392	167	22	diseases[j	diseases[j	NOUN
ajst-392	167	23	]	]	PUNCT
ajst-392	167	24	.	.	PUNCT
ajst-392	168	1	int	int	PROPN
ajst-392	168	2	j	j	PROPN
ajst-392	168	3	mol	mol	ADP
ajst-392	168	4	sci	sci	PROPN
ajst-392	168	5	,	,	PUNCT
ajst-392	168	6	2018	2018	NUM
ajst-392	168	7	,	,	PUNCT
ajst-392	168	8	19(6	19(6	NUM
ajst-392	168	9	)	)	PUNCT
ajst-392	168	10	.	.	PUNCT
ajst-392	169	1	[	[	X
ajst-392	169	2	3	3	X
ajst-392	169	3	]	]	X
ajst-392	169	4	chen	chen	PROPN
ajst-392	169	5	x	x	PROPN
ajst-392	169	6	,	,	PUNCT
ajst-392	169	7	liu	liu	PROPN
ajst-392	169	8	y	y	PROPN
ajst-392	169	9	,	,	PUNCT
ajst-392	169	10	gao	gao	PROPN
ajst-392	169	11	y	y	PROPN
ajst-392	169	12	,	,	PUNCT
ajst-392	169	13	et	et	PROPN
ajst-392	169	14	al	al	PROPN
ajst-392	169	15	.	.	PUNCT
ajst-392	170	1	the	the	DET
ajst-392	170	2	roles	role	NOUN
ajst-392	170	3	of	of	ADP
ajst-392	170	4	macrophage	macrophage	ADJ
ajst-392	170	5	polarization	polarization	NOUN
ajst-392	170	6	in	in	ADP
ajst-392	170	7	the	the	DET
ajst-392	170	8	host	host	NOUN
ajst-392	170	9	immune	immune	ADJ
ajst-392	170	10	response	response	NOUN
ajst-392	170	11	to	to	ADP
ajst-392	170	12	sepsis[j	sepsis[j	PROPN
ajst-392	170	13	]	]	PUNCT
ajst-392	170	14	.	.	PUNCT
ajst-392	171	1	int	int	PROPN
ajst-392	171	2	immunopharmacol	immunopharmacol	PROPN
ajst-392	171	3	,	,	PUNCT
ajst-392	171	4	2021	2021	NUM
ajst-392	171	5	,	,	PUNCT
ajst-392	171	6	96	96	NUM
ajst-392	171	7	:	:	SYM
ajst-392	171	8	107791	107791	NUM
ajst-392	171	9	.	.	PUNCT
ajst-392	172	1	[	[	X
ajst-392	172	2	4	4	X
ajst-392	172	3	]	]	X
ajst-392	172	4	li	li	PROPN
ajst-392	172	5	c	c	PROPN
ajst-392	172	6	,	,	PUNCT
ajst-392	172	7	xu	xu	PROPN
ajst-392	172	8	m	m	VERB
ajst-392	172	9	m	m	PROPN
ajst-392	172	10	,	,	PUNCT
ajst-392	172	11	wang	wang	PROPN
ajst-392	172	12	k	k	PROPN
ajst-392	172	13	,	,	PUNCT
ajst-392	172	14	et	et	PROPN
ajst-392	172	15	al	al	PROPN
ajst-392	172	16	.	.	PUNCT
ajst-392	172	17	macrophage	macrophage	ADJ
ajst-392	172	18	polarization	polarization	NOUN
ajst-392	172	19	and	and	CCONJ
ajst-392	172	20	meta	meta	NOUN
ajst-392	172	21	-	-	PUNCT
ajst-392	172	22	inflammation[j	inflammation[j	NOUN
ajst-392	172	23	]	]	PUNCT
ajst-392	172	24	.	.	PUNCT
ajst-392	173	1	transl	transl	PROPN
ajst-392	173	2	res	re	NOUN
ajst-392	173	3	,	,	PUNCT
ajst-392	173	4	2018	2018	NUM
ajst-392	173	5	,	,	PUNCT
ajst-392	173	6	191	191	NUM
ajst-392	173	7	:	:	SYM
ajst-392	173	8	29	29	NUM
ajst-392	173	9	-	-	SYM
ajst-392	173	10	44	44	NUM
ajst-392	173	11	.	.	PUNCT
ajst-392	174	1	[	[	X
ajst-392	174	2	5	5	X
ajst-392	174	3	]	]	X
ajst-392	174	4	billiau	billiau	NOUN
ajst-392	174	5	a	a	PRON
ajst-392	174	6	,	,	PUNCT
ajst-392	174	7	matthys	matthys	PROPN
ajst-392	174	8	p.	p.	PROPN
ajst-392	174	9	interferon	interferon	PROPN
ajst-392	174	10	-	-	PUNCT
ajst-392	174	11	gamma	gamma	NOUN
ajst-392	174	12	:	:	PUNCT
ajst-392	174	13	a	a	DET
ajst-392	174	14	historical	historical	ADJ
ajst-392	174	15	perspective[j	perspective[j	NOUN
ajst-392	174	16	]	]	PUNCT
ajst-392	174	17	.	.	PUNCT
ajst-392	175	1	cytokine	cytokine	ADJ
ajst-392	175	2	growth	growth	NOUN
ajst-392	175	3	factor	factor	NOUN
ajst-392	175	4	rev	rev	VERB
ajst-392	175	5	,	,	PUNCT
ajst-392	175	6	2009	2009	NUM
ajst-392	175	7	,	,	PUNCT
ajst-392	175	8	20(2	20(2	NUM
ajst-392	175	9	):	):	PUNCT
ajst-392	175	10	97113	97113	NUM
ajst-392	175	11	.	.	PUNCT
ajst-392	176	1	[	[	X
ajst-392	176	2	6	6	NUM
ajst-392	176	3	]	]	X
ajst-392	176	4	fujioka	fujioka	PROPN
ajst-392	176	5	s	s	PROPN
ajst-392	176	6	,	,	PUNCT
ajst-392	176	7	niu	niu	PROPN
ajst-392	176	8	j	j	PROPN
ajst-392	176	9	,	,	PUNCT
ajst-392	176	10	schmidt	schmidt	PROPN
ajst-392	176	11	c	c	PROPN
ajst-392	176	12	,	,	PUNCT
ajst-392	176	13	et	et	PROPN
ajst-392	176	14	al	al	PROPN
ajst-392	176	15	.	.	PROPN
ajst-392	176	16	nf	nf	PROPN
ajst-392	176	17	-	-	PUNCT
ajst-392	176	18	kappab	kappab	NOUN
ajst-392	176	19	and	and	CCONJ
ajst-392	176	20	ap-1	ap-1	ADV
ajst-392	176	21	connection	connection	NOUN
ajst-392	176	22	:	:	PUNCT
ajst-392	176	23	mechanism	mechanism	NOUN
ajst-392	176	24	of	of	ADP
ajst-392	176	25	nf	nf	ADJ
ajst-392	176	26	-	-	PUNCT
ajst-392	176	27	kappab	kappab	NOUN
ajst-392	176	28	-	-	PUNCT
ajst-392	176	29	dependent	dependent	ADJ
ajst-392	176	30	regulation	regulation	NOUN
ajst-392	176	31	of	of	ADP
ajst-392	176	32	ap-1	ap-1	PROPN
ajst-392	176	33	activity[j	activity[j	PROPN
ajst-392	176	34	]	]	PUNCT
ajst-392	176	35	.	.	PUNCT
ajst-392	177	1	mol	mol	ADP
ajst-392	177	2	cell	cell	NOUN
ajst-392	177	3	biol	biol	NOUN
ajst-392	177	4	,	,	PUNCT
ajst-392	177	5	2004	2004	NUM
ajst-392	177	6	,	,	PUNCT
ajst-392	177	7	24(17	24(17	NUM
ajst-392	177	8	):	):	PUNCT
ajst-392	177	9	7806	7806	NUM
ajst-392	177	10	-	-	SYM
ajst-392	177	11	7819	7819	NUM
ajst-392	177	12	.	.	PUNCT
ajst-392	178	1	[	[	X
ajst-392	178	2	7	7	X
ajst-392	178	3	]	]	X
ajst-392	178	4	akira	akira	PROPN
ajst-392	178	5	s	s	PROPN
ajst-392	178	6	,	,	PUNCT
ajst-392	178	7	uematsu	uematsu	PROPN
ajst-392	178	8	s	s	PROPN
ajst-392	178	9	,	,	PUNCT
ajst-392	178	10	takeuchi	takeuchi	PROPN
ajst-392	178	11	o.	o.	PROPN
ajst-392	178	12	pathogen	pathogen	PROPN
ajst-392	178	13	recognition	recognition	NOUN
ajst-392	178	14	and	and	CCONJ
ajst-392	178	15	innate	innate	VERB
ajst-392	178	16	immunity[j	immunity[j	NOUN
ajst-392	178	17	]	]	PUNCT
ajst-392	178	18	.	.	PUNCT
ajst-392	179	1	cell	cell	NOUN
ajst-392	179	2	,	,	PUNCT
ajst-392	179	3	2006	2006	NUM
ajst-392	179	4	,	,	PUNCT
ajst-392	179	5	124(4	124(4	NUM
ajst-392	179	6	):	):	PUNCT
ajst-392	179	7	783	783	NUM
ajst-392	179	8	-	-	SYM
ajst-392	179	9	801	801	NUM
ajst-392	179	10	.	.	PUNCT
ajst-392	180	1	[	[	X
ajst-392	180	2	8	8	X
ajst-392	180	3	]	]	PUNCT
ajst-392	180	4	brockman	brockman	PROPN
ajst-392	180	5	j	j	PROPN
ajst-392	180	6	a	a	PROPN
ajst-392	180	7	,	,	PUNCT
ajst-392	180	8	scherer	scherer	PROPN
ajst-392	180	9	d	d	PROPN
ajst-392	180	10	c	c	PROPN
ajst-392	180	11	,	,	PUNCT
ajst-392	180	12	mckinsey	mckinsey	PROPN
ajst-392	180	13	t	t	PROPN
ajst-392	180	14	a	a	PROPN
ajst-392	180	15	,	,	PUNCT
ajst-392	180	16	et	et	PROPN
ajst-392	180	17	al	al	PROPN
ajst-392	180	18	.	.	PUNCT
ajst-392	180	19	coupling	coupling	NOUN
ajst-392	180	20	of	of	ADP
ajst-392	180	21	a	a	DET
ajst-392	180	22	signal	signal	ADJ
ajst-392	180	23	response	response	NOUN
ajst-392	180	24	domain	domain	NOUN
ajst-392	180	25	in	in	ADP
ajst-392	180	26	i	i	PROPN
ajst-392	180	27	kappa	kappa	PROPN
ajst-392	181	1	b	b	X
ajst-392	181	2	alpha	alpha	NOUN
ajst-392	181	3	to	to	ADP
ajst-392	181	4	multiple	multiple	ADJ
ajst-392	181	5	pathways	pathway	NOUN
ajst-392	181	6	for	for	ADP
ajst-392	181	7	nf	nf	NOUN
ajst-392	181	8	-	-	PUNCT
ajst-392	181	9	kappa	kappa	PROPN
ajst-392	181	10	b	b	PROPN
ajst-392	181	11	activation[j	activation[j	PROPN
ajst-392	181	12	]	]	PUNCT
ajst-392	181	13	.	.	PUNCT
ajst-392	182	1	mol	mol	ADP
ajst-392	182	2	cell	cell	NOUN
ajst-392	182	3	biol	biol	NOUN
ajst-392	182	4	,	,	PUNCT
ajst-392	182	5	1995	1995	NUM
ajst-392	182	6	,	,	PUNCT
ajst-392	182	7	15(5	15(5	NUM
ajst-392	182	8	):	):	PUNCT
ajst-392	182	9	2809	2809	NUM
ajst-392	182	10	-	-	SYM
ajst-392	182	11	2818	2818	NUM
ajst-392	182	12	.	.	PUNCT
ajst-392	183	1	[	[	X
ajst-392	183	2	9	9	NUM
ajst-392	183	3	]	]	SYM
ajst-392	183	4	brown	brown	ADJ
ajst-392	183	5	k	k	NOUN
ajst-392	183	6	,	,	PUNCT
ajst-392	183	7	gerstberger	gerstberger	PROPN
ajst-392	183	8	s	s	PROPN
ajst-392	183	9	,	,	PUNCT
ajst-392	183	10	carlson	carlson	PROPN
ajst-392	183	11	l	l	PROPN
ajst-392	183	12	,	,	PUNCT
ajst-392	183	13	et	et	PROPN
ajst-392	183	14	al	al	PROPN
ajst-392	183	15	.	.	PROPN
ajst-392	183	16	control	control	PROPN
ajst-392	183	17	of	of	ADP
ajst-392	183	18	i	i	PRON
ajst-392	183	19	kappa	kappa	VERB
ajst-392	183	20	balpha	balpha	PROPN
ajst-392	183	21	proteolysis	proteolysis	NOUN
ajst-392	183	22	by	by	ADP
ajst-392	183	23	site	site	NOUN
ajst-392	183	24	-	-	PUNCT
ajst-392	183	25	specific	specific	ADJ
ajst-392	183	26	,	,	PUNCT
ajst-392	183	27	signal	signal	NOUN
ajst-392	183	28	-	-	PUNCT
ajst-392	183	29	induced	induce	VERB
ajst-392	183	30	phosphorylation[j	phosphorylation[j	NOUN
ajst-392	183	31	]	]	PUNCT
ajst-392	183	32	.	.	PUNCT
ajst-392	184	1	science	science	NOUN
ajst-392	184	2	,	,	PUNCT
ajst-392	184	3	1995	1995	NUM
ajst-392	184	4	,	,	PUNCT
ajst-392	184	5	267(5203	267(5203	NUM
ajst-392	184	6	):	):	PUNCT
ajst-392	184	7	1485	1485	NUM
ajst-392	184	8	-	-	SYM
ajst-392	184	9	1488	1488	NUM
ajst-392	184	10	.	.	PUNCT
ajst-392	185	1	[	[	X
ajst-392	185	2	10	10	NUM
ajst-392	185	3	]	]	X
ajst-392	185	4	tugal	tugal	PROPN
ajst-392	185	5	d	d	PROPN
ajst-392	185	6	,	,	PUNCT
ajst-392	185	7	liao	liao	PROPN
ajst-392	185	8	x	x	PROPN
ajst-392	185	9	,	,	PUNCT
ajst-392	185	10	jain	jain	PROPN
ajst-392	185	11	m	m	PROPN
ajst-392	185	12	k.	k.	PROPN
ajst-392	185	13	transcriptional	transcriptional	PROPN
ajst-392	185	14	control	control	NOUN
ajst-392	185	15	of	of	ADP
ajst-392	185	16	macrophage	macrophage	ADJ
ajst-392	185	17	polarization[j	polarization[j	NOUN
ajst-392	185	18	]	]	PUNCT
ajst-392	185	19	.	.	PUNCT
ajst-392	186	1	arterioscler	arterioscler	PROPN
ajst-392	186	2	thromb	thromb	PROPN
ajst-392	186	3	vasc	vasc	PROPN
ajst-392	186	4	biol	biol	PROPN
ajst-392	186	5	,	,	PUNCT
ajst-392	186	6	2013	2013	NUM
ajst-392	186	7	,	,	PUNCT
ajst-392	186	8	33(6	33(6	NUM
ajst-392	186	9	):	):	PUNCT
ajst-392	186	10	1135	1135	NUM
ajst-392	186	11	-	-	SYM
ajst-392	186	12	1144	1144	NUM
ajst-392	186	13	.	.	PUNCT
ajst-392	187	1	[	[	X
ajst-392	187	2	11	11	NUM
ajst-392	187	3	]	]	X
ajst-392	187	4	verstrepen	verstrepen	ADJ
ajst-392	187	5	l	l	NOUN
ajst-392	187	6	,	,	PUNCT
ajst-392	187	7	bekaert	bekaert	PROPN
ajst-392	187	8	t	t	PROPN
ajst-392	187	9	,	,	PUNCT
ajst-392	187	10	chau	chau	NOUN
ajst-392	187	11	t	t	PROPN
ajst-392	187	12	l	l	PROPN
ajst-392	187	13	,	,	PUNCT
ajst-392	187	14	et	et	PROPN
ajst-392	187	15	al	al	PROPN
ajst-392	187	16	.	.	PROPN
ajst-392	188	1	tlr-4	tlr-4	ADP
ajst-392	188	2	,	,	PUNCT
ajst-392	188	3	il-1r	il-1r	PROPN
ajst-392	188	4	and	and	CCONJ
ajst-392	188	5	tnf	tnf	PROPN
ajst-392	188	6	-	-	PUNCT
ajst-392	188	7	r	r	NOUN
ajst-392	188	8	signaling	signal	VERB
ajst-392	188	9	to	to	ADP
ajst-392	188	10	nf	nf	ADJ
ajst-392	188	11	-	-	PUNCT
ajst-392	188	12	kappab	kappab	NOUN
ajst-392	188	13	:	:	PUNCT
ajst-392	188	14	variations	variation	NOUN
ajst-392	188	15	on	on	ADP
ajst-392	188	16	a	a	DET
ajst-392	188	17	common	common	ADJ
ajst-392	188	18	theme[j	theme[j	NOUN
ajst-392	188	19	]	]	PUNCT
ajst-392	188	20	.	.	PUNCT
ajst-392	189	1	cell	cell	NOUN
ajst-392	189	2	mol	mol	ADP
ajst-392	189	3	life	life	PROPN
ajst-392	189	4	sci	sci	PROPN
ajst-392	189	5	,	,	PUNCT
ajst-392	189	6	2008	2008	NUM
ajst-392	189	7	,	,	PUNCT
ajst-392	189	8	65(19	65(19	NUM
ajst-392	189	9	):	):	PUNCT
ajst-392	189	10	2964	2964	NUM
ajst-392	189	11	-	-	SYM
ajst-392	189	12	2978	2978	NUM
ajst-392	189	13	.	.	PUNCT
ajst-392	190	1	[	[	X
ajst-392	190	2	12	12	NUM
ajst-392	190	3	]	]	SYM
ajst-392	190	4	tabas	tabas	PROPN
ajst-392	190	5	i	i	PROPN
ajst-392	190	6	,	,	PUNCT
ajst-392	190	7	bornfeldt	bornfeldt	PROPN
ajst-392	190	8	k	k	PROPN
ajst-392	190	9	e.	e.	PROPN
ajst-392	190	10	macrophage	macrophage	PROPN
ajst-392	190	11	phenotype	phenotype	NOUN
ajst-392	190	12	and	and	CCONJ
ajst-392	190	13	function	function	NOUN
ajst-392	190	14	in	in	ADP
ajst-392	190	15	different	different	ADJ
ajst-392	190	16	stages	stage	NOUN
ajst-392	190	17	of	of	ADP
ajst-392	190	18	atherosclerosis[j	atherosclerosis[j	NOUN
ajst-392	190	19	]	]	PUNCT
ajst-392	190	20	.	.	PUNCT
ajst-392	191	1	circ	circ	PROPN
ajst-392	191	2	res	re	NOUN
ajst-392	191	3	,	,	PUNCT
ajst-392	191	4	2016	2016	NUM
ajst-392	191	5	,	,	PUNCT
ajst-392	191	6	118(4	118(4	NUM
ajst-392	191	7	):	):	PUNCT
ajst-392	191	8	653	653	NUM
ajst-392	191	9	-	-	SYM
ajst-392	191	10	667	667	NUM
ajst-392	191	11	.	.	PUNCT
ajst-392	192	1	[	[	X
ajst-392	192	2	13	13	NUM
ajst-392	192	3	]	]	PUNCT
ajst-392	192	4	erdèlyi	erdèlyi	PROPN
ajst-392	192	5	k	k	PROPN
ajst-392	192	6	,	,	PUNCT
ajst-392	192	7	kiss	kiss	VERB
ajst-392	192	8	a	a	DET
ajst-392	192	9	,	,	PUNCT
ajst-392	192	10	bakondi	bakondi	NOUN
ajst-392	192	11	e	e	NOUN
ajst-392	192	12	,	,	PUNCT
ajst-392	192	13	et	et	PROPN
ajst-392	192	14	al	al	PROPN
ajst-392	192	15	.	.	PROPN
ajst-392	193	1	gallotannin	gallotannin	PROPN
ajst-392	193	2	inhibits	inhibit	VERB
ajst-392	193	3	the	the	DET
ajst-392	193	4	expression	expression	NOUN
ajst-392	193	5	of	of	ADP
ajst-392	193	6	chemokines	chemokine	NOUN
ajst-392	193	7	and	and	CCONJ
ajst-392	193	8	inflammatory	inflammatory	ADJ
ajst-392	193	9	cytokines	cytokine	NOUN
ajst-392	193	10	in	in	ADP
ajst-392	193	11	a549	a549	PROPN
ajst-392	193	12	cells[j	cells[j	PROPN
ajst-392	193	13	]	]	PUNCT
ajst-392	193	14	.	.	PUNCT
ajst-392	194	1	mol	mol	ADP
ajst-392	194	2	pharmacol	pharmacol	PROPN
ajst-392	194	3	,	,	PUNCT
ajst-392	194	4	2005	2005	NUM
ajst-392	194	5	,	,	PUNCT
ajst-392	194	6	68(3	68(3	NUM
ajst-392	194	7	):	):	PUNCT
ajst-392	194	8	895	895	NUM
ajst-392	194	9	-	-	SYM
ajst-392	194	10	904	904	NUM
ajst-392	194	11	.	.	PUNCT
ajst-392	195	1	[	[	X
ajst-392	195	2	14	14	NUM
ajst-392	195	3	]	]	X
ajst-392	195	4	karin	karin	PROPN
ajst-392	195	5	m.	m.	NOUN
ajst-392	195	6	the	the	DET
ajst-392	195	7	regulation	regulation	NOUN
ajst-392	195	8	of	of	ADP
ajst-392	195	9	ap-1	ap-1	ADP
ajst-392	195	10	activity	activity	NOUN
ajst-392	195	11	by	by	ADP
ajst-392	195	12	mitogen	mitogen	NOUN
ajst-392	195	13	-	-	PUNCT
ajst-392	195	14	activated	activate	VERB
ajst-392	195	15	protein	protein	NOUN
ajst-392	195	16	kinases[j	kinases[j	NOUN
ajst-392	195	17	]	]	PUNCT
ajst-392	195	18	.	.	PUNCT
ajst-392	196	1	j	j	PROPN
ajst-392	196	2	biol	biol	PROPN
ajst-392	196	3	chem	chem	NOUN
ajst-392	196	4	,	,	PUNCT
ajst-392	196	5	1995	1995	NUM
ajst-392	196	6	,	,	PUNCT
ajst-392	196	7	270(28	270(28	NUM
ajst-392	196	8	):	):	PUNCT
ajst-392	196	9	16483	16483	NUM
ajst-392	196	10	-	-	SYM
ajst-392	196	11	16486	16486	NUM
ajst-392	196	12	.	.	PUNCT
ajst-392	197	1	[	[	X
ajst-392	197	2	15	15	NUM
ajst-392	197	3	]	]	X
ajst-392	197	4	karin	karin	PROPN
ajst-392	197	5	m	m	PROPN
ajst-392	197	6	,	,	PUNCT
ajst-392	197	7	liu	liu	PROPN
ajst-392	197	8	z	z	PROPN
ajst-392	197	9	,	,	PUNCT
ajst-392	197	10	zandi	zandi	PROPN
ajst-392	197	11	e.	e.	PROPN
ajst-392	197	12	ap-1	ap-1	PROPN
ajst-392	197	13	function	function	PROPN
ajst-392	197	14	and	and	CCONJ
ajst-392	197	15	regulation[j	regulation[j	PROPN
ajst-392	197	16	]	]	PUNCT
ajst-392	197	17	.	.	PUNCT
ajst-392	198	1	curr	curr	PROPN
ajst-392	198	2	opin	opin	NOUN
ajst-392	198	3	cell	cell	NOUN
ajst-392	198	4	biol	biol	NOUN
ajst-392	198	5	,	,	PUNCT
ajst-392	198	6	1997	1997	NUM
ajst-392	198	7	,	,	PUNCT
ajst-392	198	8	9(2	9(2	NUM
ajst-392	198	9	):	):	PUNCT
ajst-392	198	10	240	240	NUM
ajst-392	198	11	-	-	SYM
ajst-392	198	12	246	246	NUM
ajst-392	198	13	.	.	PUNCT
ajst-392	199	1	[	[	X
ajst-392	199	2	16	16	NUM
ajst-392	199	3	]	]	PUNCT
ajst-392	199	4	williams	williams	PROPN
ajst-392	199	5	g	g	PROPN
ajst-392	199	6	w.	w.	PROPN
ajst-392	199	7	an	an	DET
ajst-392	199	8	update	update	NOUN
ajst-392	199	9	on	on	ADP
ajst-392	199	10	nonsteroidal	nonsteroidal	NOUN
ajst-392	199	11	anti	anti	ADJ
ajst-392	199	12	-	-	ADJ
ajst-392	199	13	inflammatory	inflammatory	ADJ
ajst-392	199	14	drugs	drug	NOUN
ajst-392	199	15	and	and	CCONJ
ajst-392	199	16	cyclooxygenase-2	cyclooxygenase-2	NUM
ajst-392	199	17	inhibitors[j	inhibitors[j	NOUN
ajst-392	199	18	]	]	PUNCT
ajst-392	199	19	.	.	PUNCT
ajst-392	200	1	curr	curr	PROPN
ajst-392	200	2	pain	pain	PROPN
ajst-392	200	3	headache	headache	PROPN
ajst-392	200	4	rep	rep	PROPN
ajst-392	200	5	,	,	PUNCT
ajst-392	200	6	2005	2005	NUM
ajst-392	200	7	,	,	PUNCT
ajst-392	200	8	9(6	9(6	NUM
ajst-392	200	9	):	):	PUNCT
ajst-392	200	10	377	377	NUM
ajst-392	200	11	-	-	SYM
ajst-392	200	12	389	389	NUM
ajst-392	200	13	.	.	PUNCT
ajst-392	201	1	[	[	X
ajst-392	201	2	17	17	NUM
ajst-392	201	3	]	]	X
ajst-392	201	4	walter	walter	PROPN
ajst-392	201	5	m	m	PROPN
ajst-392	201	6	f	f	PROPN
ajst-392	201	7	,	,	PUNCT
ajst-392	201	8	jacob	jacob	PROPN
ajst-392	201	9	r	r	PROPN
ajst-392	201	10	f	f	PROPN
ajst-392	201	11	,	,	PUNCT
ajst-392	201	12	day	day	NOUN
ajst-392	201	13	c	c	PROPN
ajst-392	201	14	a	a	X
ajst-392	201	15	,	,	PUNCT
ajst-392	201	16	et	et	PROPN
ajst-392	201	17	al	al	PROPN
ajst-392	201	18	.	.	PROPN
ajst-392	201	19	sulfone	sulfone	NOUN
ajst-392	201	20	cox-2	cox-2	ADP
ajst-392	201	21	inhibitors	inhibitor	NOUN
ajst-392	201	22	increase	increase	VERB
ajst-392	201	23	susceptibility	susceptibility	NOUN
ajst-392	201	24	of	of	ADP
ajst-392	201	25	human	human	ADJ
ajst-392	201	26	ldl	ldl	NOUN
ajst-392	201	27	and	and	CCONJ
ajst-392	201	28	plasma	plasma	NOUN
ajst-392	201	29	to	to	PART
ajst-392	201	30	oxidative	oxidative	ADJ
ajst-392	201	31	modification	modification	NOUN
ajst-392	201	32	:	:	PUNCT
ajst-392	201	33	comparison	comparison	NOUN
ajst-392	201	34	to	to	PART
ajst-392	201	35	sulfonamide	sulfonamide	VERB
ajst-392	201	36	cox-2	cox-2	ADJ
ajst-392	201	37	inhibitors	inhibitor	NOUN
ajst-392	201	38	and	and	CCONJ
ajst-392	201	39	nsaids[j	nsaids[j	NOUN
ajst-392	201	40	]	]	PUNCT
ajst-392	201	41	.	.	PUNCT
ajst-392	202	1	atherosclerosis	atherosclerosis	NOUN
ajst-392	202	2	,	,	PUNCT
ajst-392	202	3	2004	2004	NUM
ajst-392	202	4	,	,	PUNCT
ajst-392	202	5	177(2	177(2	NUM
ajst-392	202	6	):	):	PUNCT
ajst-392	202	7	235	235	NUM
ajst-392	202	8	-	-	SYM
ajst-392	202	9	243	243	NUM
ajst-392	202	10	.	.	PUNCT
ajst-392	203	1	[	[	X
ajst-392	203	2	18	18	NUM
ajst-392	203	3	]	]	PUNCT
ajst-392	203	4	traversa	traversa	PROPN
ajst-392	203	5	g	g	PROPN
ajst-392	203	6	,	,	PUNCT
ajst-392	203	7	bianchi	bianchi	NOUN
ajst-392	203	8	c	c	AUX
ajst-392	203	9	,	,	PUNCT
ajst-392	203	10	da	da	PROPN
ajst-392	203	11	cas	cas	PROPN
ajst-392	203	12	r	r	PROPN
ajst-392	203	13	,	,	PUNCT
ajst-392	203	14	et	et	PROPN
ajst-392	203	15	al	al	PROPN
ajst-392	203	16	.	.	PROPN
ajst-392	203	17	cohort	cohort	PROPN
ajst-392	203	18	study	study	NOUN
ajst-392	203	19	of	of	ADP
ajst-392	203	20	hepatotoxicity	hepatotoxicity	NOUN
ajst-392	203	21	associated	associate	VERB
ajst-392	203	22	with	with	ADP
ajst-392	203	23	nimesulide	nimesulide	NOUN
ajst-392	203	24	and	and	CCONJ
ajst-392	203	25	other	other	ADJ
ajst-392	203	26	nonsteroidal	nonsteroidal	ADJ
ajst-392	203	27	anti	anti	ADJ
ajst-392	203	28	-	-	ADJ
ajst-392	203	29	inflammatory	inflammatory	ADJ
ajst-392	203	30	drugs[j	drugs[j	NOUN
ajst-392	203	31	]	]	PUNCT
ajst-392	203	32	.	.	PUNCT
ajst-392	204	1	bmj	bmj	PROPN
ajst-392	204	2	,	,	PUNCT
ajst-392	204	3	2003	2003	NUM
ajst-392	204	4	,	,	PUNCT
ajst-392	204	5	327(7405	327(7405	NUM
ajst-392	204	6	):	):	PUNCT
ajst-392	204	7	18	18	NUM
ajst-392	204	8	-	-	SYM
ajst-392	204	9	22	22	NUM
ajst-392	204	10	.	.	PUNCT
ajst-392	205	1	[	[	X
ajst-392	205	2	19	19	NUM
ajst-392	205	3	]	]	X
ajst-392	205	4	zhou	zhou	PROPN
ajst-392	205	5	l	l	PROPN
ajst-392	205	6	,	,	PUNCT
ajst-392	205	7	pang	pang	NOUN
ajst-392	205	8	x	x	PRON
ajst-392	205	9	,	,	PUNCT
ajst-392	205	10	jiang	jiang	PROPN
ajst-392	205	11	j	j	PROPN
ajst-392	205	12	,	,	PUNCT
ajst-392	205	13	et	et	PROPN
ajst-392	205	14	al	al	PROPN
ajst-392	205	15	.	.	PROPN
ajst-392	205	16	nimesulide	nimesulide	PROPN
ajst-392	205	17	and	and	CCONJ
ajst-392	205	18	4'hydroxynimesulide	4'hydroxynimesulide	NUM
ajst-392	205	19	as	as	SCONJ
ajst-392	205	20	bile	bile	NOUN
ajst-392	205	21	acid	acid	NOUN
ajst-392	205	22	transporters	transporter	NOUN
ajst-392	205	23	inhibitors	inhibitor	NOUN
ajst-392	205	24	are	be	AUX
ajst-392	205	25	contributory	contributory	NOUN
ajst-392	205	26	factors	factor	NOUN
ajst-392	205	27	for	for	ADP
ajst-392	205	28	drug	drug	NOUN
ajst-392	205	29	-	-	PUNCT
ajst-392	205	30	induced	induce	VERB
ajst-392	205	31	cholestasis[j	cholestasis[j	PROPN
ajst-392	205	32	]	]	PUNCT
ajst-392	205	33	.	.	PUNCT
ajst-392	206	1	drug	drug	NOUN
ajst-392	206	2	metab	metab	PROPN
ajst-392	206	3	dispos	dispos	PROPN
ajst-392	206	4	,	,	PUNCT
ajst-392	206	5	2017	2017	NUM
ajst-392	206	6	,	,	PUNCT
ajst-392	206	7	45(5	45(5	NUM
ajst-392	206	8	):	):	PUNCT
ajst-392	206	9	441	441	NUM
ajst-392	206	10	-	-	SYM
ajst-392	206	11	448	448	NUM
ajst-392	206	12	.	.	PUNCT
ajst-392	207	1	[	[	X
ajst-392	207	2	20	20	NUM
ajst-392	207	3	]	]	PUNCT
ajst-392	207	4	mcadam	mcadam	PROPN
ajst-392	207	5	b	b	PROPN
ajst-392	207	6	f	f	PROPN
ajst-392	207	7	,	,	PUNCT
ajst-392	207	8	catella	catella	PROPN
ajst-392	207	9	-	-	PUNCT
ajst-392	207	10	lawson	lawson	PROPN
ajst-392	207	11	f	f	PROPN
ajst-392	207	12	,	,	PUNCT
ajst-392	207	13	mardini	mardini	VERB
ajst-392	207	14	i	i	PRON
ajst-392	207	15	a	a	X
ajst-392	207	16	,	,	PUNCT
ajst-392	207	17	et	et	PROPN
ajst-392	207	18	al	al	PROPN
ajst-392	207	19	.	.	PUNCT
ajst-392	207	20	systemic	systemic	ADJ
ajst-392	207	21	biosynthesis	biosynthesis	NOUN
ajst-392	207	22	of	of	ADP
ajst-392	207	23	prostacyclin	prostacyclin	NOUN
ajst-392	207	24	by	by	ADP
ajst-392	207	25	cyclooxygenase	cyclooxygenase	NOUN
ajst-392	207	26	(	(	PUNCT
ajst-392	207	27	cox)-2	cox)-2	PROPN
ajst-392	207	28	:	:	PUNCT
ajst-392	207	29	the	the	DET
ajst-392	207	30	human	human	ADJ
ajst-392	207	31	pharmacology	pharmacology	NOUN
ajst-392	207	32	of	of	ADP
ajst-392	207	33	a	a	DET
ajst-392	207	34	selective	selective	ADJ
ajst-392	207	35	inhibitor	inhibitor	NOUN
ajst-392	207	36	of	of	ADP
ajst-392	207	37	cox-2[j	cox-2[j	NOUN
ajst-392	207	38	]	]	PUNCT
ajst-392	207	39	.	.	PUNCT
ajst-392	208	1	proc	proc	PROPN
ajst-392	208	2	natl	natl	PROPN
ajst-392	208	3	acad	acad	PROPN
ajst-392	208	4	sci	sci	PROPN
ajst-392	208	5	u	u	PROPN
ajst-392	208	6	s	s	PROPN
ajst-392	208	7	a	a	PRON
ajst-392	208	8	,	,	PUNCT
ajst-392	208	9	1999	1999	NUM
ajst-392	208	10	,	,	PUNCT
ajst-392	208	11	96(1	96(1	NUM
ajst-392	208	12	):	):	PUNCT
ajst-392	208	13	272	272	NUM
ajst-392	208	14	-	-	SYM
ajst-392	208	15	277	277	NUM
ajst-392	208	16	.	.	PUNCT
ajst-392	209	1	[	[	X
ajst-392	209	2	21	21	NUM
ajst-392	209	3	]	]	PUNCT
ajst-392	209	4	chiolero	chiolero	NOUN
ajst-392	209	5	a	a	DET
ajst-392	209	6	,	,	PUNCT
ajst-392	209	7	maillard	maillard	NOUN
ajst-392	209	8	m	m	VERB
ajst-392	209	9	p	p	NOUN
ajst-392	209	10	,	,	PUNCT
ajst-392	209	11	burnier	burnier	ADJ
ajst-392	209	12	m.	m.	NOUN
ajst-392	209	13	cardiovascular	cardiovascular	ADJ
ajst-392	209	14	hazard	hazard	NOUN
ajst-392	209	15	of	of	ADP
ajst-392	209	16	selective	selective	ADJ
ajst-392	209	17	cox-2	cox-2	ADJ
ajst-392	209	18	inhibitors	inhibitor	NOUN
ajst-392	209	19	:	:	PUNCT
ajst-392	209	20	myth	myth	NOUN
ajst-392	209	21	or	or	CCONJ
ajst-392	209	22	reality?[j	reality?[j	NOUN
ajst-392	209	23	]	]	PUNCT
ajst-392	209	24	.	.	PUNCT
ajst-392	210	1	expert	expert	NOUN
ajst-392	210	2	opin	opin	NOUN
ajst-392	210	3	drug	drug	NOUN
ajst-392	210	4	saf	saf	PROPN
ajst-392	210	5	,	,	PUNCT
ajst-392	210	6	2002	2002	NUM
ajst-392	210	7	,	,	PUNCT
ajst-392	210	8	1(1	1(1	NUM
ajst-392	210	9	):	):	PUNCT
ajst-392	210	10	45	45	NUM
ajst-392	210	11	-	-	SYM
ajst-392	210	12	52	52	NUM
ajst-392	210	13	.	.	PUNCT
ajst-392	211	1	[	[	X
ajst-392	211	2	22	22	NUM
ajst-392	211	3	]	]	PUNCT
ajst-392	211	4	gomariz	gomariz	NOUN
ajst-392	211	5	r	r	NOUN
ajst-392	211	6	p	p	NOUN
ajst-392	211	7	,	,	PUNCT
ajst-392	211	8	juarranz	juarranz	PROPN
ajst-392	211	9	y	y	PROPN
ajst-392	211	10	,	,	PUNCT
ajst-392	211	11	abad	abad	PROPN
ajst-392	211	12	c	c	X
ajst-392	211	13	,	,	PUNCT
ajst-392	211	14	et	et	PROPN
ajst-392	211	15	al	al	PROPN
ajst-392	211	16	.	.	PROPN
ajst-392	211	17	vip	vip	NOUN
ajst-392	211	18	-	-	PUNCT
ajst-392	211	19	pacap	pacap	NOUN
ajst-392	211	20	system	system	NOUN
ajst-392	211	21	in	in	ADP
ajst-392	211	22	immunity	immunity	NOUN
ajst-392	211	23	:	:	PUNCT
ajst-392	211	24	new	new	ADJ
ajst-392	211	25	insights	insight	NOUN
ajst-392	211	26	for	for	ADP
ajst-392	211	27	multitarget	multitarget	NOUN
ajst-392	211	28	therapy[j	therapy[j	NOUN
ajst-392	211	29	]	]	PUNCT
ajst-392	211	30	.	.	PUNCT
ajst-392	212	1	ann	ann	PROPN
ajst-392	212	2	n	n	PROPN
ajst-392	212	3	y	y	PROPN
ajst-392	212	4	acad	acad	PROPN
ajst-392	212	5	sci	sci	PROPN
ajst-392	212	6	,	,	PUNCT
ajst-392	212	7	2006	2006	NUM
ajst-392	212	8	,	,	PUNCT
ajst-392	212	9	1070	1070	NUM
ajst-392	212	10	:	:	PUNCT
ajst-392	212	11	51	51	NUM
ajst-392	212	12	-	-	SYM
ajst-392	212	13	74	74	NUM
ajst-392	212	14	.	.	PUNCT
ajst-392	213	1	[	[	X
ajst-392	213	2	23	23	NUM
ajst-392	213	3	]	]	X
ajst-392	213	4	dong	dong	PROPN
ajst-392	213	5	d	d	PROPN
ajst-392	213	6	,	,	PUNCT
ajst-392	213	7	zhou	zhou	PROPN
ajst-392	213	8	n	n	PROPN
ajst-392	213	9	n	n	CCONJ
ajst-392	213	10	,	,	PUNCT
ajst-392	213	11	liu	liu	PROPN
ajst-392	213	12	r	r	PROPN
ajst-392	213	13	x	x	PROPN
ajst-392	213	14	,	,	PUNCT
ajst-392	213	15	et	et	PROPN
ajst-392	213	16	al	al	PROPN
ajst-392	213	17	.	.	PUNCT
ajst-392	213	18	sarsasapogenin	sarsasapogenin	PROPN
ajst-392	213	19	-	-	PUNCT
ajst-392	213	20	aa13	aa13	PROPN
ajst-392	213	21	inhibits	inhibit	VERB
ajst-392	213	22	lps	lps	PROPN
ajst-392	213	23	-	-	PUNCT
ajst-392	213	24	induced	induce	VERB
ajst-392	213	25	inflammatory	inflammatory	ADJ
ajst-392	213	26	responses	response	NOUN
ajst-392	213	27	in	in	ADP
ajst-392	213	28	macrophage	macrophage	ADJ
ajst-392	213	29	cells	cell	NOUN
ajst-392	213	30	in	in	ADP
ajst-392	213	31	vitro	vitro	X
ajst-392	213	32	and	and	CCONJ
ajst-392	213	33	relieves	relieve	VERB
ajst-392	213	34	dimethylbenzene	dimethylbenzene	NOUN
ajst-392	213	35	-	-	PUNCT
ajst-392	213	36	induced	induce	VERB
ajst-392	213	37	ear	ear	NOUN
ajst-392	213	38	edema	edema	NOUN
ajst-392	213	39	in	in	ADP
ajst-392	213	40	mice[j	mice[j	PROPN
ajst-392	213	41	]	]	PUNCT
ajst-392	213	42	.	.	PUNCT
ajst-392	214	1	acta	acta	PROPN
ajst-392	214	2	pharmacol	pharmacol	PROPN
ajst-392	214	3	sin	sin	NOUN
ajst-392	214	4	,	,	PUNCT
ajst-392	214	5	2017	2017	NUM
ajst-392	214	6	,	,	PUNCT
ajst-392	214	7	38(5	38(5	NUM
ajst-392	214	8	):	):	PUNCT
ajst-392	214	9	699	699	NUM
ajst-392	214	10	-	-	SYM
ajst-392	214	11	709	709	NUM
ajst-392	214	12	.	.	PUNCT
ajst-392	215	1	[	[	X
ajst-392	215	2	24	24	NUM
ajst-392	215	3	]	]	X
ajst-392	215	4	kimura	kimura	NOUN
ajst-392	215	5	c	c	NOUN
ajst-392	215	6	,	,	PUNCT
ajst-392	215	7	ohkubo	ohkubo	VERB
ajst-392	215	8	s	s	NOUN
ajst-392	215	9	,	,	PUNCT
ajst-392	215	10	ogi	ogi	PROPN
ajst-392	215	11	k	k	PROPN
ajst-392	215	12	,	,	PUNCT
ajst-392	215	13	et	et	PROPN
ajst-392	215	14	al	al	PROPN
ajst-392	215	15	.	.	PUNCT
ajst-392	216	1	a	a	DET
ajst-392	216	2	novel	novel	NOUN
ajst-392	216	3	peptide	peptide	NOUN
ajst-392	216	4	which	which	PRON
ajst-392	216	5	stimulates	stimulate	VERB
ajst-392	216	6	adenylate	adenylate	ADJ
ajst-392	216	7	cyclase	cyclase	NOUN
ajst-392	216	8	:	:	PUNCT
ajst-392	216	9	molecular	molecular	ADJ
ajst-392	216	10	cloning	cloning	NOUN
ajst-392	216	11	and	and	CCONJ
ajst-392	216	12	characterization	characterization	NOUN
ajst-392	216	13	of	of	ADP
ajst-392	216	14	the	the	DET
ajst-392	216	15	ovine	ovine	ADJ
ajst-392	216	16	and	and	CCONJ
ajst-392	216	17	human	human	PROPN
ajst-392	216	18	cdnas[j	cdnas[j	PROPN
ajst-392	216	19	]	]	PROPN
ajst-392	216	20	.	.	PUNCT
ajst-392	217	1	biochem	biochem	PROPN
ajst-392	217	2	biophys	biophys	PROPN
ajst-392	217	3	res	re	NOUN
ajst-392	217	4	commun	commun	PROPN
ajst-392	217	5	,	,	PUNCT
ajst-392	217	6	1990	1990	NUM
ajst-392	217	7	,	,	PUNCT
ajst-392	217	8	166(1	166(1	NUM
ajst-392	217	9	):	):	PUNCT
ajst-392	217	10	81	81	NUM
ajst-392	217	11	-	-	SYM
ajst-392	217	12	89	89	NUM
ajst-392	217	13	.	.	PUNCT
ajst-392	218	1	[	[	X
ajst-392	218	2	25	25	NUM
ajst-392	218	3	]	]	X
ajst-392	218	4	ogi	ogi	PROPN
ajst-392	218	5	k	k	PROPN
ajst-392	218	6	,	,	PUNCT
ajst-392	218	7	kimura	kimura	NOUN
ajst-392	218	8	c	c	NOUN
ajst-392	218	9	,	,	PUNCT
ajst-392	218	10	onda	onda	PROPN
ajst-392	218	11	h	h	PROPN
ajst-392	218	12	,	,	PUNCT
ajst-392	218	13	et	et	PROPN
ajst-392	218	14	al	al	PROPN
ajst-392	218	15	.	.	PROPN
ajst-392	218	16	molecular	molecular	ADJ
ajst-392	218	17	cloning	cloning	NOUN
ajst-392	218	18	and	and	CCONJ
ajst-392	218	19	characterization	characterization	NOUN
ajst-392	218	20	of	of	ADP
ajst-392	218	21	cdna	cdna	PROPN
ajst-392	218	22	for	for	ADP
ajst-392	218	23	the	the	DET
ajst-392	218	24	precursor	precursor	NOUN
ajst-392	218	25	of	of	ADP
ajst-392	218	26	rat	rat	NOUN
ajst-392	218	27	pituitary	pituitary	ADJ
ajst-392	218	28	adenylate	adenylate	ADJ
ajst-392	218	29	cyclase	cyclase	NOUN
ajst-392	218	30	activating	activate	VERB
ajst-392	218	31	polypeptide	polypeptide	ADJ
ajst-392	218	32	(	(	PUNCT
ajst-392	218	33	pacap)[j	pacap)[j	NOUN
ajst-392	218	34	]	]	PUNCT
ajst-392	218	35	.	.	PUNCT
ajst-392	219	1	biochem	biochem	PROPN
ajst-392	219	2	biophys	biophys	PROPN
ajst-392	219	3	res	re	NOUN
ajst-392	219	4	commun	commun	PROPN
ajst-392	219	5	,	,	PUNCT
ajst-392	219	6	1990	1990	NUM
ajst-392	219	7	,	,	PUNCT
ajst-392	219	8	173(3	173(3	NUM
ajst-392	219	9	):	):	PUNCT
ajst-392	219	10	1271	1271	NUM
ajst-392	219	11	-	-	SYM
ajst-392	219	12	1279	1279	NUM
ajst-392	219	13	.	.	PUNCT
ajst-392	220	1	[	[	X
ajst-392	220	2	26	26	NUM
ajst-392	220	3	]	]	X
ajst-392	220	4	chartrel	chartrel	NOUN
ajst-392	220	5	n	n	CCONJ
ajst-392	220	6	,	,	PUNCT
ajst-392	220	7	tonon	tonon	PROPN
ajst-392	220	8	m	m	NOUN
ajst-392	220	9	c	c	NOUN
ajst-392	220	10	,	,	PUNCT
ajst-392	220	11	vaudry	vaudry	ADJ
ajst-392	220	12	h	h	NOUN
ajst-392	220	13	,	,	PUNCT
ajst-392	220	14	et	et	PROPN
ajst-392	220	15	al	al	PROPN
ajst-392	220	16	.	.	PROPN
ajst-392	220	17	primary	primary	ADJ
ajst-392	220	18	structure	structure	NOUN
ajst-392	220	19	of	of	ADP
ajst-392	220	20	frog	frog	ADJ
ajst-392	220	21	pituitary	pituitary	ADJ
ajst-392	220	22	adenylate	adenylate	ADJ
ajst-392	220	23	cyclase	cyclase	NOUN
ajst-392	220	24	-	-	PUNCT
ajst-392	220	25	activating	activate	VERB
ajst-392	220	26	polypeptide	polypeptide	ADJ
ajst-392	220	27	(	(	PUNCT
ajst-392	220	28	pacap	pacap	NOUN
ajst-392	220	29	)	)	PUNCT
ajst-392	220	30	and	and	CCONJ
ajst-392	220	31	effects	effect	NOUN
ajst-392	220	32	of	of	ADP
ajst-392	220	33	ovine	ovine	ADJ
ajst-392	220	34	pacap	pacap	NOUN
ajst-392	220	35	on	on	ADP
ajst-392	220	36	frog	frog	NOUN
ajst-392	220	37	pituitary[j	pituitary[j	NOUN
ajst-392	220	38	]	]	PUNCT
ajst-392	220	39	.	.	PUNCT
ajst-392	221	1	endocrinology	endocrinology	NOUN
ajst-392	221	2	,	,	PUNCT
ajst-392	221	3	1991	1991	NUM
ajst-392	221	4	,	,	PUNCT
ajst-392	221	5	129(6	129(6	NUM
ajst-392	221	6	):	):	PUNCT
ajst-392	221	7	3367	3367	NUM
ajst-392	221	8	-	-	SYM
ajst-392	221	9	3371	3371	NUM
ajst-392	221	10	.	.	PUNCT
ajst-392	222	1	[	[	X
ajst-392	222	2	27	27	NUM
ajst-392	222	3	]	]	X
ajst-392	222	4	doyle	doyle	PROPN
ajst-392	222	5	s	s	PROPN
ajst-392	222	6	l	l	NOUN
ajst-392	222	7	,	,	PUNCT
ajst-392	222	8	o'neill	o'neill	PROPN
ajst-392	222	9	l	l	NOUN
ajst-392	222	10	a.	a.	NOUN
ajst-392	222	11	toll	toll	NOUN
ajst-392	222	12	-	-	PUNCT
ajst-392	222	13	like	like	ADJ
ajst-392	222	14	receptors	receptor	NOUN
ajst-392	222	15	:	:	PUNCT
ajst-392	222	16	from	from	ADP
ajst-392	222	17	the	the	DET
ajst-392	222	18	discovery	discovery	NOUN
ajst-392	222	19	of	of	ADP
ajst-392	222	20	nfkappab	nfkappab	NOUN
ajst-392	222	21	to	to	ADP
ajst-392	222	22	new	new	ADJ
ajst-392	222	23	insights	insight	NOUN
ajst-392	222	24	into	into	ADP
ajst-392	222	25	transcriptional	transcriptional	ADJ
ajst-392	222	26	regulations	regulation	NOUN
ajst-392	222	27	in	in	ADP
ajst-392	222	28	innate	innate	ADJ
ajst-392	222	29	immunity[j	immunity[j	PROPN
ajst-392	222	30	]	]	PUNCT
ajst-392	222	31	.	.	PUNCT
ajst-392	222	32	biochem	biochem	PROPN
ajst-392	222	33	pharmacol	pharmacol	PROPN
ajst-392	222	34	,	,	PUNCT
ajst-392	222	35	2006	2006	NUM
ajst-392	222	36	,	,	PUNCT
ajst-392	222	37	72(9	72(9	NUM
ajst-392	222	38	):	):	PUNCT
ajst-392	222	39	11021113	11021113	NUM
ajst-392	222	40	.	.	PUNCT
ajst-392	223	1	[	[	X
ajst-392	223	2	28	28	NUM
ajst-392	223	3	]	]	X
ajst-392	223	4	zhu	zhu	PROPN
ajst-392	223	5	t	t	PROPN
ajst-392	223	6	,	,	PUNCT
ajst-392	223	7	wang	wang	PROPN
ajst-392	224	1	d	d	PROPN
ajst-392	224	2	x	x	PROPN
ajst-392	224	3	,	,	PUNCT
ajst-392	224	4	zhang	zhang	PROPN
ajst-392	224	5	w	w	PROPN
ajst-392	224	6	,	,	PUNCT
ajst-392	224	7	et	et	PROPN
ajst-392	224	8	al	al	PROPN
ajst-392	224	9	.	.	PUNCT
ajst-392	225	1	andrographolide	andrographolide	ADJ
ajst-392	225	2	protects	protect	VERB
ajst-392	225	3	against	against	ADP
ajst-392	225	4	lps	lps	PROPN
ajst-392	225	5	-	-	PUNCT
ajst-392	225	6	induced	induce	VERB
ajst-392	225	7	acute	acute	ADJ
ajst-392	225	8	lung	lung	NOUN
ajst-392	225	9	injury	injury	NOUN
ajst-392	225	10	by	by	ADP
ajst-392	225	11	inactivation	inactivation	NOUN
ajst-392	225	12	of	of	ADP
ajst-392	225	13	nfκb[j	nfκb[j	NOUN
ajst-392	225	14	]	]	PUNCT
ajst-392	225	15	.	.	PUNCT
ajst-392	226	1	plos	plos	PROPN
ajst-392	226	2	one	one	NUM
ajst-392	226	3	,	,	PUNCT
ajst-392	226	4	2013	2013	NUM
ajst-392	226	5	,	,	PUNCT
ajst-392	226	6	8(2	8(2	NUM
ajst-392	226	7	):	):	PUNCT
ajst-392	226	8	e56407	e56407	NOUN
ajst-392	226	9	.	.	PUNCT
ajst-392	227	1	[	[	X
ajst-392	227	2	29	29	NUM
ajst-392	227	3	]	]	X
ajst-392	227	4	zhu	zhu	PROPN
ajst-392	227	5	t	t	PROPN
ajst-392	227	6	,	,	PUNCT
ajst-392	227	7	wu	wu	PROPN
ajst-392	227	8	x	x	PROPN
ajst-392	227	9	l	l	PROPN
ajst-392	227	10	,	,	PUNCT
ajst-392	227	11	zhang	zhang	PROPN
ajst-392	227	12	w	w	PROPN
ajst-392	227	13	,	,	PUNCT
ajst-392	227	14	et	et	PROPN
ajst-392	227	15	al	al	PROPN
ajst-392	227	16	.	.	PUNCT
ajst-392	227	17	glucagon	glucagon	PROPN
ajst-392	227	18	like	like	ADP
ajst-392	227	19	peptide-1	peptide-1	PROPN
ajst-392	227	20	(	(	PUNCT
ajst-392	227	21	glp1	glp1	NOUN
ajst-392	227	22	)	)	PUNCT
ajst-392	227	23	modulates	modulate	VERB
ajst-392	227	24	ova	ova	NOUN
ajst-392	227	25	-	-	PUNCT
ajst-392	227	26	induced	induce	VERB
ajst-392	227	27	airway	airway	NOUN
ajst-392	227	28	inflammation	inflammation	NOUN
ajst-392	227	29	and	and	CCONJ
ajst-392	227	30	mucus	mucus	NOUN
ajst-392	227	31	secretion	secretion	NOUN
ajst-392	227	32	involving	involve	VERB
ajst-392	227	33	a	a	DET
ajst-392	227	34	protein	protein	NOUN
ajst-392	227	35	kinase	kinase	NOUN
ajst-392	227	36	a	a	DET
ajst-392	227	37	(	(	PUNCT
ajst-392	227	38	pka)-dependent	pka)-dependent	NOUN
ajst-392	227	39	nuclear	nuclear	ADJ
ajst-392	227	40	19	19	NUM
ajst-392	227	41	factor	factor	NOUN
ajst-392	227	42	-	-	PUNCT
ajst-392	227	43	κb	κb	PROPN
ajst-392	227	44	(	(	PUNCT
ajst-392	227	45	nf	nf	NOUN
ajst-392	227	46	-	-	PUNCT
ajst-392	227	47	κb	κb	NOUN
ajst-392	227	48	)	)	PUNCT
ajst-392	227	49	signaling	signal	VERB
ajst-392	227	50	pathway	pathway	NOUN
ajst-392	227	51	in	in	ADP
ajst-392	227	52	mice[j	mice[j	PROPN
ajst-392	227	53	]	]	PUNCT
ajst-392	227	54	.	.	PUNCT
ajst-392	228	1	int	int	PROPN
ajst-392	228	2	j	j	PROPN
ajst-392	228	3	mol	mol	ADP
ajst-392	228	4	sci	sci	PROPN
ajst-392	228	5	,	,	PUNCT
ajst-392	228	6	2015	2015	NUM
ajst-392	228	7	,	,	PUNCT
ajst-392	228	8	16(9	16(9	NUM
ajst-392	228	9	):	):	PUNCT
ajst-392	228	10	20195	20195	NUM
ajst-392	228	11	-	-	SYM
ajst-392	228	12	20211	20211	NUM
ajst-392	228	13	.	.	PUNCT
ajst-392	229	1	[	[	X
ajst-392	229	2	30	30	NUM
ajst-392	229	3	]	]	X
ajst-392	229	4	yin	yin	PROPN
ajst-392	229	5	m	m	PROPN
ajst-392	229	6	j	j	PROPN
ajst-392	229	7	,	,	PUNCT
ajst-392	229	8	yamamoto	yamamoto	PROPN
ajst-392	229	9	y	y	PROPN
ajst-392	229	10	,	,	PUNCT
ajst-392	229	11	gaynor	gaynor	PROPN
ajst-392	229	12	r	r	PROPN
ajst-392	229	13	b.	b.	PROPN
ajst-392	229	14	the	the	DET
ajst-392	229	15	anti	anti	ADJ
ajst-392	229	16	-	-	ADJ
ajst-392	229	17	inflammatory	inflammatory	ADJ
ajst-392	229	18	agents	agent	NOUN
ajst-392	229	19	aspirin	aspirin	NOUN
ajst-392	229	20	and	and	CCONJ
ajst-392	229	21	salicylate	salicylate	NOUN
ajst-392	229	22	inhibit	inhibit	VERB
ajst-392	229	23	the	the	DET
ajst-392	229	24	activity	activity	NOUN
ajst-392	229	25	of	of	ADP
ajst-392	229	26	i(kappa)b	i(kappa)b	PROPN
ajst-392	229	27	kinase	kinase	NOUN
ajst-392	229	28	-	-	PUNCT
ajst-392	229	29	beta[j	beta[j	NOUN
ajst-392	229	30	]	]	PUNCT
ajst-392	229	31	.	.	PUNCT
ajst-392	230	1	nature	nature	NOUN
ajst-392	230	2	,	,	PUNCT
ajst-392	230	3	1998	1998	NUM
ajst-392	230	4	,	,	PUNCT
ajst-392	230	5	396(6706	396(6706	NUM
ajst-392	230	6	):	):	PUNCT
ajst-392	230	7	77	77	NUM
ajst-392	230	8	-	-	SYM
ajst-392	230	9	80	80	NUM
ajst-392	230	10	.	.	PUNCT
ajst-392	231	1	[	[	X
ajst-392	231	2	31	31	NUM
ajst-392	231	3	]	]	X
ajst-392	231	4	dziarski	dziarski	ADJ
ajst-392	231	5	r	r	NOUN
ajst-392	231	6	,	,	PUNCT
ajst-392	231	7	jin	jin	NOUN
ajst-392	231	8	y	y	PROPN
ajst-392	231	9	p	p	PROPN
ajst-392	231	10	,	,	PUNCT
ajst-392	231	11	gupta	gupta	PROPN
ajst-392	231	12	d.	d.	PROPN
ajst-392	231	13	differential	differential	PROPN
ajst-392	231	14	activation	activation	NOUN
ajst-392	231	15	of	of	ADP
ajst-392	231	16	extracellular	extracellular	ADJ
ajst-392	231	17	signal	signal	NOUN
ajst-392	231	18	-	-	PUNCT
ajst-392	231	19	regulated	regulate	VERB
ajst-392	231	20	kinase	kinase	NOUN
ajst-392	231	21	(	(	PUNCT
ajst-392	231	22	erk	erk	PROPN
ajst-392	231	23	)	)	PUNCT
ajst-392	231	24	1	1	NUM
ajst-392	231	25	,	,	PUNCT
ajst-392	231	26	erk2	erk2	NOUN
ajst-392	231	27	,	,	PUNCT
ajst-392	231	28	p38	p38	NOUN
ajst-392	231	29	,	,	PUNCT
ajst-392	231	30	and	and	CCONJ
ajst-392	231	31	cjun	cjun	PROPN
ajst-392	231	32	nh2	nh2	PROPN
ajst-392	231	33	-	-	PUNCT
ajst-392	231	34	terminal	terminal	PROPN
ajst-392	231	35	kinase	kinase	PROPN
ajst-392	231	36	mitogen	mitogen	PROPN
ajst-392	231	37	-	-	PUNCT
ajst-392	231	38	activated	activate	VERB
ajst-392	231	39	protein	protein	NOUN
ajst-392	231	40	kinases	kinase	NOUN
ajst-392	231	41	by	by	ADP
ajst-392	231	42	bacterial	bacterial	ADJ
ajst-392	231	43	peptidoglycan[j	peptidoglycan[j	PROPN
ajst-392	231	44	]	]	PUNCT
ajst-392	231	45	.	.	PUNCT
ajst-392	232	1	j	j	PROPN
ajst-392	232	2	infect	infect	VERB
ajst-392	232	3	dis	dis	PROPN
ajst-392	232	4	,	,	PUNCT
ajst-392	232	5	1996	1996	NUM
ajst-392	232	6	,	,	PUNCT
ajst-392	232	7	174(4	174(4	NUM
ajst-392	232	8	):	):	PUNCT
ajst-392	232	9	777	777	NUM
ajst-392	232	10	-	-	SYM
ajst-392	232	11	785	785	NUM
ajst-392	232	12	.	.	PUNCT
ajst-392	233	1	[	[	X
ajst-392	233	2	32	32	NUM
ajst-392	233	3	]	]	X
ajst-392	233	4	chang	chang	PROPN
ajst-392	233	5	s	s	PROPN
ajst-392	233	6	y	y	PROPN
ajst-392	233	7	,	,	PUNCT
ajst-392	233	8	kim	kim	PROPN
ajst-392	233	9	d	d	PROPN
ajst-392	233	10	b	b	PROPN
ajst-392	233	11	,	,	PUNCT
ajst-392	233	12	ryu	ryu	PROPN
ajst-392	233	13	g	g	PROPN
ajst-392	233	14	r	r	PROPN
ajst-392	233	15	,	,	PUNCT
ajst-392	233	16	et	et	PROPN
ajst-392	233	17	al	al	PROPN
ajst-392	233	18	.	.	PROPN
ajst-392	234	1	exendin-4	exendin-4	PROPN
ajst-392	234	2	inhibits	inhibit	VERB
ajst-392	234	3	inos	ino	NOUN
ajst-392	234	4	expression	expression	NOUN
ajst-392	234	5	at	at	ADP
ajst-392	234	6	the	the	DET
ajst-392	234	7	protein	protein	NOUN
ajst-392	234	8	level	level	NOUN
ajst-392	234	9	in	in	ADP
ajst-392	234	10	lps	lps	PROPN
ajst-392	234	11	-	-	PUNCT
ajst-392	234	12	stimulated	stimulate	VERB
ajst-392	234	13	raw264.7	raw264.7	NOUN
ajst-392	234	14	macrophage	macrophage	NOUN
ajst-392	234	15	by	by	ADP
ajst-392	234	16	the	the	DET
ajst-392	234	17	activation	activation	NOUN
ajst-392	234	18	of	of	ADP
ajst-392	234	19	camp	camp	NOUN
ajst-392	234	20	/	/	SYM
ajst-392	234	21	pka	pka	PROPN
ajst-392	234	22	pathway[j	pathway[j	NOUN
ajst-392	234	23	]	]	PUNCT
ajst-392	234	24	.	.	PUNCT
ajst-392	235	1	j	j	PROPN
ajst-392	235	2	cell	cell	PROPN
ajst-392	235	3	biochem	biochem	PROPN
ajst-392	235	4	,	,	PUNCT
ajst-392	235	5	2013	2013	NUM
ajst-392	235	6	,	,	PUNCT
ajst-392	235	7	114(4	114(4	NUM
ajst-392	235	8	):	):	PUNCT
ajst-392	235	9	844	844	NUM
ajst-392	235	10	-	-	SYM
ajst-392	235	11	853	853	NUM
ajst-392	235	12	.	.	PUNCT
ajst-392	236	1	[	[	X
ajst-392	236	2	33	33	NUM
ajst-392	236	3	]	]	PUNCT
ajst-392	236	4	koide	koide	NOUN
ajst-392	236	5	n	n	SYM
ajst-392	236	6	,	,	PUNCT
ajst-392	236	7	sugiyama	sugiyama	PROPN
ajst-392	236	8	t	t	PROPN
ajst-392	236	9	,	,	PUNCT
ajst-392	236	10	mori	mori	PROPN
ajst-392	237	1	i	i	PRON
ajst-392	237	2	,	,	PUNCT
ajst-392	237	3	et	et	PROPN
ajst-392	237	4	al	al	PROPN
ajst-392	237	5	.	.	PUNCT
ajst-392	238	1	c2	c2	PROPN
ajst-392	238	2	-	-	PUNCT
ajst-392	238	3	ceramide	ceramide	NOUN
ajst-392	238	4	inhibits	inhibit	VERB
ajst-392	238	5	lpsinduced	lpsinduce	VERB
ajst-392	238	6	nitric	nitric	ADJ
ajst-392	238	7	oxide	oxide	NOUN
ajst-392	238	8	production	production	NOUN
ajst-392	238	9	in	in	ADP
ajst-392	238	10	raw	raw	ADJ
ajst-392	238	11	264.7	264.7	NUM
ajst-392	238	12	macrophage	macrophage	ADJ
ajst-392	238	13	cells	cell	NOUN
ajst-392	238	14	through	through	ADP
ajst-392	238	15	down	down	ADV
ajst-392	238	16	-	-	PUNCT
ajst-392	238	17	regulating	regulate	VERB
ajst-392	238	18	the	the	DET
ajst-392	238	19	activation	activation	NOUN
ajst-392	238	20	of	of	ADP
ajst-392	238	21	akt[j	akt[j	NOUN
ajst-392	238	22	]	]	PUNCT
ajst-392	238	23	.	.	PUNCT
ajst-392	239	1	j	j	PROPN
ajst-392	239	2	endotoxin	endotoxin	PROPN
ajst-392	239	3	res	re	NOUN
ajst-392	239	4	,	,	PUNCT
ajst-392	239	5	2003	2003	NUM
ajst-392	239	6	,	,	PUNCT
ajst-392	239	7	9(2	9(2	NUM
ajst-392	239	8	):	):	PUNCT
ajst-392	239	9	85	85	NUM
ajst-392	239	10	-	-	SYM
ajst-392	239	11	90	90	NUM
ajst-392	239	12	.	.	PUNCT