id	sid	tid	token	lemma	pos
ajst-405	1	1	academic	academic	ADJ
ajst-405	1	2	journal	journal	NOUN
ajst-405	1	3	of	of	ADP
ajst-405	1	4	science	science	NOUN
ajst-405	1	5	and	and	CCONJ
ajst-405	1	6	technology	technology	NOUN
ajst-405	1	7	issn	issn	NOUN
ajst-405	1	8	:	:	PUNCT
ajst-405	1	9	2771	2771	NUM
ajst-405	1	10	-	-	SYM
ajst-405	1	11	3032	3032	NUM
ajst-405	1	12	|	|	NOUN
ajst-405	1	13	vol	vol	NOUN
ajst-405	1	14	.	.	PROPN
ajst-405	2	1	1	1	NUM
ajst-405	2	2	,	,	PUNCT
ajst-405	2	3	no	no	INTJ
ajst-405	2	4	.	.	NOUN
ajst-405	2	5	3	3	NUM
ajst-405	2	6	,	,	PUNCT
ajst-405	2	7	2022	2022	NUM
ajst-405	2	8	40	40	NUM
ajst-405	2	9	development	development	NOUN
ajst-405	2	10	and	and	CCONJ
ajst-405	2	11	application	application	NOUN
ajst-405	2	12	of	of	ADP
ajst-405	2	13	suppositories	suppository	NOUN
ajst-405	2	14	in	in	ADP
ajst-405	2	15	modern	modern	ADJ
ajst-405	2	16	pharmaceutics	pharmaceutic	NOUN
ajst-405	2	17	yunqi	yunqi	PROPN
ajst-405	2	18	man	man	PROPN
ajst-405	2	19	,	,	PUNCT
ajst-405	2	20	chengcheng	chengcheng	PROPN
ajst-405	2	21	liu	liu	PROPN
ajst-405	2	22	school	school	PROPN
ajst-405	2	23	of	of	ADP
ajst-405	2	24	shenyang	shenyang	PROPN
ajst-405	2	25	pharmaceutical	pharmaceutical	PROPN
ajst-405	2	26	university	university	PROPN
ajst-405	2	27	,	,	PUNCT
ajst-405	2	28	liaoning	liaoning	NOUN
ajst-405	2	29	117000	117000	NUM
ajst-405	2	30	,	,	PUNCT
ajst-405	2	31	china	china	PROPN
ajst-405	2	32	abstract	abstract	PROPN
ajst-405	2	33	:	:	PUNCT
ajst-405	2	34	suppositories	suppository	NOUN
ajst-405	2	35	have	have	VERB
ajst-405	2	36	a	a	DET
ajst-405	2	37	long	long	ADJ
ajst-405	2	38	history	history	NOUN
ajst-405	2	39	of	of	ADP
ajst-405	2	40	development	development	NOUN
ajst-405	2	41	and	and	CCONJ
ajst-405	2	42	have	have	AUX
ajst-405	2	43	become	become	VERB
ajst-405	2	44	one	one	NUM
ajst-405	2	45	of	of	ADP
ajst-405	2	46	the	the	DET
ajst-405	2	47	commonly	commonly	ADV
ajst-405	2	48	used	use	VERB
ajst-405	2	49	dosage	dosage	NOUN
ajst-405	2	50	forms	form	NOUN
ajst-405	2	51	for	for	ADP
ajst-405	2	52	clinical	clinical	ADJ
ajst-405	2	53	use	use	NOUN
ajst-405	2	54	.	.	PUNCT
ajst-405	3	1	with	with	ADP
ajst-405	3	2	the	the	DET
ajst-405	3	3	continuous	continuous	ADJ
ajst-405	3	4	development	development	NOUN
ajst-405	3	5	of	of	ADP
ajst-405	3	6	formulation	formulation	NOUN
ajst-405	3	7	technology	technology	NOUN
ajst-405	3	8	,	,	PUNCT
ajst-405	3	9	researchers	researcher	NOUN
ajst-405	3	10	have	have	AUX
ajst-405	3	11	developed	develop	VERB
ajst-405	3	12	a	a	DET
ajst-405	3	13	variety	variety	NOUN
ajst-405	3	14	of	of	ADP
ajst-405	3	15	novel	novel	ADJ
ajst-405	3	16	formulations	formulation	NOUN
ajst-405	3	17	,	,	PUNCT
ajst-405	3	18	making	make	VERB
ajst-405	3	19	them	they	PRON
ajst-405	3	20	not	not	PART
ajst-405	3	21	only	only	ADV
ajst-405	3	22	limited	limit	VERB
ajst-405	3	23	to	to	ADP
ajst-405	3	24	topical	topical	ADJ
ajst-405	3	25	medication	medication	NOUN
ajst-405	3	26	,	,	PUNCT
ajst-405	3	27	but	but	CCONJ
ajst-405	3	28	also	also	ADV
ajst-405	3	29	can	can	AUX
ajst-405	3	30	be	be	AUX
ajst-405	3	31	absorbed	absorb	VERB
ajst-405	3	32	by	by	ADP
ajst-405	3	33	the	the	DET
ajst-405	3	34	luminal	luminal	ADJ
ajst-405	3	35	tract	tract	NOUN
ajst-405	3	36	to	to	ADP
ajst-405	3	37	the	the	DET
ajst-405	3	38	blood	blood	NOUN
ajst-405	3	39	to	to	PART
ajst-405	3	40	play	play	VERB
ajst-405	3	41	a	a	DET
ajst-405	3	42	systemic	systemic	ADJ
ajst-405	3	43	role	role	NOUN
ajst-405	3	44	.	.	PUNCT
ajst-405	4	1	this	this	DET
ajst-405	4	2	article	article	NOUN
ajst-405	4	3	mainly	mainly	ADV
ajst-405	4	4	provides	provide	VERB
ajst-405	4	5	a	a	DET
ajst-405	4	6	brief	brief	ADJ
ajst-405	4	7	review	review	NOUN
ajst-405	4	8	of	of	ADP
ajst-405	4	9	the	the	DET
ajst-405	4	10	introduction	introduction	NOUN
ajst-405	4	11	,	,	PUNCT
ajst-405	4	12	matrix	matrix	NOUN
ajst-405	4	13	species	specie	NOUN
ajst-405	4	14	,	,	PUNCT
ajst-405	4	15	characteristics	characteristic	NOUN
ajst-405	4	16	,	,	PUNCT
ajst-405	4	17	and	and	CCONJ
ajst-405	4	18	novel	novel	ADJ
ajst-405	4	19	suppositories	suppository	NOUN
ajst-405	4	20	.	.	PUNCT
ajst-405	5	1	keywords	keyword	NOUN
ajst-405	5	2	:	:	PUNCT
ajst-405	5	3	suppositories	suppository	NOUN
ajst-405	5	4	,	,	PUNCT
ajst-405	5	5	pharmaceutical	pharmaceutical	ADJ
ajst-405	5	6	agents	agent	NOUN
ajst-405	5	7	,	,	PUNCT
ajst-405	5	8	research	research	NOUN
ajst-405	5	9	advances	advance	NOUN
ajst-405	5	10	.	.	PUNCT
ajst-405	6	1	1	1	X
ajst-405	6	2	.	.	X
ajst-405	6	3	embolic	embolic	ADJ
ajst-405	6	4	background	background	NOUN
ajst-405	6	5	introduction	introduction	NOUN
ajst-405	6	6	suppositories	suppository	NOUN
ajst-405	6	7	,	,	PUNCT
ajst-405	6	8	one	one	NUM
ajst-405	6	9	of	of	ADP
ajst-405	6	10	the	the	DET
ajst-405	6	11	common	common	ADJ
ajst-405	6	12	dosage	dosage	NOUN
ajst-405	6	13	forms	form	NOUN
ajst-405	6	14	of	of	ADP
ajst-405	6	15	drugs	drug	NOUN
ajst-405	6	16	,	,	PUNCT
ajst-405	6	17	have	have	VERB
ajst-405	6	18	a	a	DET
ajst-405	6	19	long	long	ADJ
ajst-405	6	20	history	history	NOUN
ajst-405	6	21	in	in	ADP
ajst-405	6	22	china	china	PROPN
ajst-405	6	23	,	,	PUNCT
ajst-405	6	24	and	and	CCONJ
ajst-405	6	25	ear	ear	NOUN
ajst-405	6	26	plugs	plug	NOUN
ajst-405	6	27	,	,	PUNCT
ajst-405	6	28	nasal	nasal	ADJ
ajst-405	6	29	plugs	plug	NOUN
ajst-405	6	30	,	,	PUNCT
ajst-405	6	31	anal	anal	ADJ
ajst-405	6	32	plugs	plug	NOUN
ajst-405	6	33	,	,	PUNCT
ajst-405	6	34	vaginal	vaginal	ADJ
ajst-405	6	35	plugs	plug	NOUN
ajst-405	6	36	,	,	PUNCT
ajst-405	6	37	urethral	urethral	ADJ
ajst-405	6	38	plugs	plug	NOUN
ajst-405	6	39	,	,	PUNCT
ajst-405	6	40	etc	etc	X
ajst-405	6	41	.	.	X
ajst-405	6	42	are	be	AUX
ajst-405	6	43	contained	contain	VERB
ajst-405	6	44	in	in	ADP
ajst-405	6	45	the	the	DET
ajst-405	6	46	compendium	compendium	NOUN
ajst-405	6	47	of	of	ADP
ajst-405	6	48	materia	materia	PROPN
ajst-405	6	49	medica	medica	PROPN
ajst-405	6	50	by	by	ADP
ajst-405	6	51	li	li	PROPN
ajst-405	6	52	shizhen	shizhen	ADV
ajst-405	6	53	in	in	ADP
ajst-405	6	54	the	the	DET
ajst-405	6	55	ming	ming	NOUN
ajst-405	6	56	dynasty	dynasty	NOUN
ajst-405	7	1	[	[	X
ajst-405	7	2	1	1	NUM
ajst-405	7	3	]	]	PUNCT
ajst-405	7	4	.	.	PUNCT
ajst-405	8	1	at	at	ADP
ajst-405	8	2	first	first	ADV
ajst-405	8	3	,	,	PUNCT
ajst-405	8	4	it	it	PRON
ajst-405	8	5	was	be	AUX
ajst-405	8	6	only	only	ADV
ajst-405	8	7	applied	apply	VERB
ajst-405	8	8	for	for	ADP
ajst-405	8	9	topical	topical	ADJ
ajst-405	8	10	use	use	NOUN
ajst-405	8	11	such	such	ADJ
ajst-405	8	12	as	as	ADP
ajst-405	8	13	lubrication	lubrication	NOUN
ajst-405	8	14	,	,	PUNCT
ajst-405	8	15	sterilization	sterilization	NOUN
ajst-405	8	16	,	,	PUNCT
ajst-405	8	17	local	local	ADJ
ajst-405	8	18	anaesthesia	anaesthesia	NOUN
ajst-405	8	19	,	,	PUNCT
ajst-405	8	20	anti	anti	ADJ
ajst-405	8	21	insect	insect	NOUN
ajst-405	8	22	and	and	CCONJ
ajst-405	8	23	convergence	convergence	NOUN
ajst-405	8	24	,	,	PUNCT
ajst-405	8	25	and	and	CCONJ
ajst-405	8	26	later	later	ADV
ajst-405	8	27	with	with	ADP
ajst-405	8	28	the	the	DET
ajst-405	8	29	development	development	NOUN
ajst-405	8	30	of	of	ADP
ajst-405	8	31	technology	technology	NOUN
ajst-405	8	32	,	,	PUNCT
ajst-405	8	33	people	people	NOUN
ajst-405	8	34	have	have	AUX
ajst-405	8	35	found	find	VERB
ajst-405	8	36	that	that	SCONJ
ajst-405	8	37	drugs	drug	NOUN
ajst-405	8	38	in	in	ADP
ajst-405	8	39	suppositories	suppository	NOUN
ajst-405	8	40	can	can	AUX
ajst-405	8	41	exert	exert	VERB
ajst-405	8	42	systemic	systemic	ADJ
ajst-405	8	43	therapeutic	therapeutic	ADJ
ajst-405	8	44	effects	effect	NOUN
ajst-405	8	45	through	through	ADP
ajst-405	8	46	intestinal	intestinal	ADJ
ajst-405	8	47	mucosal	mucosal	NOUN
ajst-405	8	48	absorption	absorption	NOUN
ajst-405	8	49	in	in	ADP
ajst-405	8	50	addition	addition	NOUN
ajst-405	8	51	to	to	ADP
ajst-405	8	52	the	the	DET
ajst-405	8	53	above	above	ADJ
ajst-405	8	54	functions	function	NOUN
ajst-405	8	55	.	.	PUNCT
ajst-405	9	1	with	with	ADP
ajst-405	9	2	the	the	DET
ajst-405	9	3	development	development	NOUN
ajst-405	9	4	of	of	ADP
ajst-405	9	5	pharmaceutics	pharmaceutic	NOUN
ajst-405	9	6	,	,	PUNCT
ajst-405	9	7	so	so	SCONJ
ajst-405	9	8	that	that	SCONJ
ajst-405	9	9	suppositories	suppository	NOUN
ajst-405	9	10	have	have	AUX
ajst-405	9	11	also	also	ADV
ajst-405	9	12	been	be	AUX
ajst-405	9	13	further	far	ADV
ajst-405	9	14	developed	develop	VERB
ajst-405	9	15	.	.	PUNCT
ajst-405	10	1	the	the	DET
ajst-405	10	2	commonly	commonly	ADV
ajst-405	10	3	used	use	VERB
ajst-405	10	4	matrices	matrix	NOUN
ajst-405	10	5	for	for	ADP
ajst-405	10	6	suppositories	suppository	NOUN
ajst-405	10	7	are	be	AUX
ajst-405	10	8	divided	divide	VERB
ajst-405	10	9	into	into	ADP
ajst-405	10	10	an	an	DET
ajst-405	10	11	oily	oily	ADJ
ajst-405	10	12	matrix	matrix	NOUN
ajst-405	10	13	and	and	CCONJ
ajst-405	10	14	a	a	DET
ajst-405	10	15	water	water	NOUN
ajst-405	10	16	-	-	PUNCT
ajst-405	10	17	soluble	soluble	ADJ
ajst-405	10	18	matrix	matrix	NOUN
ajst-405	10	19	.	.	PUNCT
ajst-405	11	1	the	the	DET
ajst-405	11	2	oily	oily	ADJ
ajst-405	11	3	matrix	matrix	NOUN
ajst-405	11	4	cocoa	cocoa	NOUN
ajst-405	11	5	bean	bean	NOUN
ajst-405	11	6	fat	fat	NOUN
ajst-405	11	7	is	be	AUX
ajst-405	11	8	a	a	DET
ajst-405	11	9	solid	solid	ADJ
ajst-405	11	10	fat	fat	NOUN
ajst-405	11	11	that	that	PRON
ajst-405	11	12	is	be	AUX
ajst-405	11	13	stable	stable	ADJ
ajst-405	11	14	,	,	PUNCT
ajst-405	11	15	rapidly	rapidly	ADV
ajst-405	11	16	melts	melt	NOUN
ajst-405	11	17	,	,	PUNCT
ajst-405	11	18	and	and	CCONJ
ajst-405	11	19	is	be	AUX
ajst-405	11	20	non	non	NOUN
ajst-405	11	21	irritating	irritate	VERB
ajst-405	11	22	,	,	PUNCT
ajst-405	11	23	but	but	CCONJ
ajst-405	11	24	is	be	AUX
ajst-405	11	25	used	use	VERB
ajst-405	11	26	less	less	ADV
ajst-405	11	27	often	often	ADV
ajst-405	11	28	because	because	SCONJ
ajst-405	11	29	of	of	ADP
ajst-405	11	30	its	its	PRON
ajst-405	11	31	high	high	ADJ
ajst-405	11	32	price	price	NOUN
ajst-405	11	33	.	.	PUNCT
ajst-405	12	1	the	the	DET
ajst-405	12	2	water	water	NOUN
ajst-405	12	3	-	-	PUNCT
ajst-405	12	4	soluble	soluble	ADJ
ajst-405	12	5	matrix	matrix	NOUN
ajst-405	12	6	is	be	AUX
ajst-405	12	7	mainly	mainly	ADV
ajst-405	12	8	glycerol	glycerol	NOUN
ajst-405	12	9	gelatin	gelatin	NOUN
ajst-405	12	10	and	and	CCONJ
ajst-405	12	11	polyethylene	polyethylene	NOUN
ajst-405	12	12	glycol	glycol	NOUN
ajst-405	12	13	(	(	PUNCT
ajst-405	12	14	peg	peg	NOUN
ajst-405	12	15	)	)	PUNCT
ajst-405	12	16	.	.	PUNCT
ajst-405	13	1	glycerin	glycerin	NOUN
ajst-405	13	2	gelatin	gelatin	NOUN
ajst-405	13	3	systems	system	NOUN
ajst-405	13	4	are	be	AUX
ajst-405	13	5	made	make	VERB
ajst-405	13	6	of	of	ADP
ajst-405	13	7	gelatin	gelatin	NOUN
ajst-405	13	8	,	,	PUNCT
ajst-405	13	9	glycerin	glycerin	NOUN
ajst-405	13	10	and	and	CCONJ
ajst-405	13	11	water	water	NOUN
ajst-405	13	12	,	,	PUNCT
ajst-405	13	13	are	be	AUX
ajst-405	13	14	elastic	elastic	ADJ
ajst-405	13	15	,	,	PUNCT
ajst-405	13	16	do	do	AUX
ajst-405	13	17	not	not	PART
ajst-405	13	18	break	break	VERB
ajst-405	13	19	easily	easily	ADV
ajst-405	13	20	,	,	PUNCT
ajst-405	13	21	can	can	AUX
ajst-405	13	22	slowly	slowly	ADV
ajst-405	13	23	dissolve	dissolve	VERB
ajst-405	13	24	in	in	ADP
ajst-405	13	25	the	the	DET
ajst-405	13	26	secretory	secretory	ADJ
ajst-405	13	27	fluid	fluid	NOUN
ajst-405	13	28	after	after	ADP
ajst-405	13	29	sealing	seal	VERB
ajst-405	13	30	into	into	ADP
ajst-405	13	31	the	the	DET
ajst-405	13	32	lumen	luman	NOUN
ajst-405	13	33	,	,	PUNCT
ajst-405	13	34	and	and	CCONJ
ajst-405	13	35	can	can	AUX
ajst-405	13	36	prolong	prolong	VERB
ajst-405	13	37	the	the	DET
ajst-405	13	38	drug	drug	NOUN
ajst-405	13	39	's	's	PART
ajst-405	13	40	efficacy	efficacy	NOUN
ajst-405	13	41	,	,	PUNCT
ajst-405	13	42	but	but	CCONJ
ajst-405	13	43	the	the	DET
ajst-405	13	44	dissolution	dissolution	NOUN
ajst-405	13	45	rate	rate	NOUN
ajst-405	13	46	changes	change	NOUN
ajst-405	13	47	as	as	ADP
ajst-405	13	48	the	the	DET
ajst-405	13	49	ratio	ratio	NOUN
ajst-405	13	50	between	between	ADP
ajst-405	13	51	gelatin	gelatin	NOUN
ajst-405	13	52	,	,	PUNCT
ajst-405	13	53	glycerin	glycerin	NOUN
ajst-405	13	54	and	and	CCONJ
ajst-405	13	55	water	water	NOUN
ajst-405	13	56	changes	change	NOUN
ajst-405	13	57	,	,	PUNCT
ajst-405	13	58	so	so	CCONJ
ajst-405	13	59	the	the	DET
ajst-405	13	60	preparation	preparation	NOUN
ajst-405	13	61	of	of	ADP
ajst-405	13	62	such	such	ADJ
ajst-405	13	63	suppositories	suppository	NOUN
ajst-405	13	64	requires	require	VERB
ajst-405	13	65	different	different	ADJ
ajst-405	13	66	matrix	matrix	NOUN
ajst-405	13	67	ratios	ratio	NOUN
ajst-405	13	68	depending	depend	VERB
ajst-405	13	69	on	on	ADP
ajst-405	13	70	the	the	DET
ajst-405	13	71	therapeutic	therapeutic	ADJ
ajst-405	13	72	purpose	purpose	NOUN
ajst-405	13	73	.	.	PUNCT
ajst-405	14	1	some	some	DET
ajst-405	14	2	additional	additional	ADJ
ajst-405	14	3	agents	agent	NOUN
ajst-405	14	4	are	be	AUX
ajst-405	14	5	also	also	ADV
ajst-405	14	6	added	add	VERB
ajst-405	14	7	to	to	ADP
ajst-405	14	8	suppositories	suppository	NOUN
ajst-405	14	9	,	,	PUNCT
ajst-405	14	10	and	and	CCONJ
ajst-405	14	11	features	feature	NOUN
ajst-405	14	12	may	may	AUX
ajst-405	14	13	include	include	VERB
ajst-405	14	14	absorption	absorption	NOUN
ajst-405	14	15	enhancers	enhancer	NOUN
ajst-405	14	16	,	,	PUNCT
ajst-405	14	17	absorption	absorption	NOUN
ajst-405	14	18	blockers	blocker	NOUN
ajst-405	14	19	,	,	PUNCT
ajst-405	14	20	plasticizers	plasticizer	NOUN
ajst-405	14	21	,	,	PUNCT
ajst-405	14	22	and	and	CCONJ
ajst-405	14	23	others	other	NOUN
ajst-405	14	24	.	.	PUNCT
ajst-405	15	1	in	in	ADP
ajst-405	15	2	the	the	DET
ajst-405	15	3	hope	hope	NOUN
ajst-405	15	4	of	of	ADP
ajst-405	15	5	improving	improve	VERB
ajst-405	15	6	matrix	matrix	NOUN
ajst-405	15	7	stickiness	stickiness	NOUN
ajst-405	15	8	and	and	CCONJ
ajst-405	15	9	increasing	increase	VERB
ajst-405	15	10	drug	drug	NOUN
ajst-405	15	11	efficacy	efficacy	NOUN
ajst-405	15	12	.	.	PUNCT
ajst-405	16	1	preparations	preparation	NOUN
ajst-405	16	2	of	of	ADP
ajst-405	16	3	suppositories	suppository	NOUN
ajst-405	16	4	can	can	AUX
ajst-405	16	5	be	be	AUX
ajst-405	16	6	divided	divide	VERB
ajst-405	16	7	into	into	ADP
ajst-405	16	8	3	3	NUM
ajst-405	16	9	types	type	NOUN
ajst-405	16	10	:	:	PUNCT
ajst-405	16	11	kneading	knead	VERB
ajst-405	16	12	,	,	PUNCT
ajst-405	16	13	cold	cold	ADJ
ajst-405	16	14	pressing	pressing	NOUN
ajst-405	16	15	,	,	PUNCT
ajst-405	16	16	and	and	CCONJ
ajst-405	16	17	hot	hot	ADJ
ajst-405	16	18	dissolving	dissolving	NOUN
ajst-405	16	19	.	.	PUNCT
ajst-405	17	1	general	general	ADJ
ajst-405	17	2	oily	oily	ADJ
ajst-405	17	3	matrices	matrix	NOUN
ajst-405	17	4	employ	employ	VERB
ajst-405	17	5	any	any	PRON
ajst-405	17	6	of	of	ADP
ajst-405	17	7	3	3	NUM
ajst-405	17	8	methods	method	NOUN
ajst-405	17	9	,	,	PUNCT
ajst-405	17	10	while	while	SCONJ
ajst-405	17	11	water	water	NOUN
ajst-405	17	12	-	-	PUNCT
ajst-405	17	13	soluble	soluble	ADJ
ajst-405	17	14	matrices	matrix	NOUN
ajst-405	17	15	mostly	mostly	ADV
ajst-405	17	16	employ	employ	VERB
ajst-405	17	17	hot	hot	ADJ
ajst-405	17	18	-	-	PUNCT
ajst-405	17	19	melt	melt	NOUN
ajst-405	17	20	method	method	NOUN
ajst-405	17	21	[	[	X
ajst-405	17	22	2	2	NUM
ajst-405	17	23	]	]	PUNCT
ajst-405	17	24	.	.	PUNCT
ajst-405	18	1	a	a	DET
ajst-405	18	2	qualified	qualified	ADJ
ajst-405	18	3	suppository	suppository	NOUN
ajst-405	18	4	should	should	AUX
ajst-405	18	5	have	have	VERB
ajst-405	18	6	the	the	DET
ajst-405	18	7	following	follow	VERB
ajst-405	18	8	requirements	requirement	NOUN
ajst-405	18	9	(	(	PUNCT
ajst-405	18	10	1	1	X
ajst-405	18	11	)	)	PUNCT
ajst-405	18	12	the	the	DET
ajst-405	18	13	drug	drug	NOUN
ajst-405	18	14	and	and	CCONJ
ajst-405	18	15	matrix	matrix	NOUN
ajst-405	18	16	should	should	AUX
ajst-405	18	17	be	be	AUX
ajst-405	18	18	mixed	mixed	ADJ
ajst-405	18	19	and	and	CCONJ
ajst-405	18	20	uniform	uniform	ADJ
ajst-405	18	21	,	,	PUNCT
ajst-405	18	22	and	and	CCONJ
ajst-405	18	23	the	the	DET
ajst-405	18	24	external	external	ADJ
ajst-405	18	25	shape	shape	NOUN
ajst-405	18	26	of	of	ADP
ajst-405	18	27	the	the	DET
ajst-405	18	28	suppository	suppository	NOUN
ajst-405	18	29	should	should	AUX
ajst-405	18	30	be	be	AUX
ajst-405	18	31	complete	complete	ADJ
ajst-405	18	32	and	and	CCONJ
ajst-405	18	33	smooth	smooth	ADJ
ajst-405	18	34	,	,	PUNCT
ajst-405	18	35	without	without	ADP
ajst-405	18	36	irritation	irritation	NOUN
ajst-405	18	37	.	.	PUNCT
ajst-405	19	1	(	(	PUNCT
ajst-405	19	2	2	2	X
ajst-405	19	3	)	)	PUNCT
ajst-405	19	4	after	after	ADP
ajst-405	19	5	clogging	clog	VERB
ajst-405	19	6	into	into	ADP
ajst-405	19	7	the	the	DET
ajst-405	19	8	lumen	luman	NOUN
ajst-405	19	9	,	,	PUNCT
ajst-405	19	10	it	it	PRON
ajst-405	19	11	should	should	AUX
ajst-405	19	12	melt	melt	VERB
ajst-405	19	13	,	,	PUNCT
ajst-405	19	14	soften	soften	VERB
ajst-405	19	15	or	or	CCONJ
ajst-405	19	16	dissolve	dissolve	VERB
ajst-405	19	17	,	,	PUNCT
ajst-405	19	18	and	and	CCONJ
ajst-405	19	19	mix	mix	VERB
ajst-405	19	20	with	with	ADP
ajst-405	19	21	the	the	DET
ajst-405	19	22	secretory	secretory	ADJ
ajst-405	19	23	fluid	fluid	NOUN
ajst-405	19	24	to	to	PART
ajst-405	19	25	gradually	gradually	ADV
ajst-405	19	26	release	release	VERB
ajst-405	19	27	the	the	DET
ajst-405	19	28	drug	drug	NOUN
ajst-405	19	29	,	,	PUNCT
ajst-405	19	30	producing	produce	VERB
ajst-405	19	31	local	local	ADJ
ajst-405	19	32	or	or	CCONJ
ajst-405	19	33	systemic	systemic	ADJ
ajst-405	19	34	effects	effect	NOUN
ajst-405	19	35	.	.	PUNCT
ajst-405	20	1	(	(	PUNCT
ajst-405	20	2	3	3	X
ajst-405	20	3	)	)	PUNCT
ajst-405	20	4	suitable	suitable	ADJ
ajst-405	20	5	hardness	hardness	NOUN
ajst-405	20	6	to	to	PART
ajst-405	20	7	avoid	avoid	VERB
ajst-405	20	8	deformation	deformation	NOUN
ajst-405	20	9	during	during	ADP
ajst-405	20	10	packaging	packaging	NOUN
ajst-405	20	11	,	,	PUNCT
ajst-405	20	12	storage	storage	NOUN
ajst-405	20	13	or	or	CCONJ
ajst-405	20	14	use	use	NOUN
ajst-405	20	15	[	[	X
ajst-405	20	16	3	3	NUM
ajst-405	20	17	]	]	PUNCT
ajst-405	20	18	.	.	PUNCT
ajst-405	21	1	for	for	ADP
ajst-405	21	2	systemic	systemic	ADJ
ajst-405	21	3	administration	administration	NOUN
ajst-405	21	4	,	,	PUNCT
ajst-405	21	5	compared	compare	VERB
ajst-405	21	6	with	with	ADP
ajst-405	21	7	oral	oral	ADJ
ajst-405	21	8	preparations	preparation	NOUN
ajst-405	21	9	,	,	PUNCT
ajst-405	21	10	suppositories	suppository	NOUN
ajst-405	21	11	have	have	VERB
ajst-405	21	12	a	a	DET
ajst-405	21	13	relatively	relatively	ADV
ajst-405	21	14	rapid	rapid	ADJ
ajst-405	21	15	absorption	absorption	NOUN
ajst-405	21	16	and	and	CCONJ
ajst-405	21	17	onset	onset	NOUN
ajst-405	21	18	of	of	ADP
ajst-405	21	19	action	action	NOUN
ajst-405	21	20	,	,	PUNCT
ajst-405	21	21	a	a	DET
ajst-405	21	22	small	small	ADJ
ajst-405	21	23	first	first	ADJ
ajst-405	21	24	pass	pass	NOUN
ajst-405	21	25	effect	effect	NOUN
ajst-405	21	26	on	on	ADP
ajst-405	21	27	the	the	DET
ajst-405	21	28	liver	liver	NOUN
ajst-405	21	29	,	,	PUNCT
ajst-405	21	30	and	and	CCONJ
ajst-405	21	31	better	well	ADJ
ajst-405	21	32	efficacy	efficacy	NOUN
ajst-405	21	33	,	,	PUNCT
ajst-405	21	34	but	but	CCONJ
ajst-405	21	35	also	also	ADV
ajst-405	21	36	avoid	avoid	VERB
ajst-405	21	37	irritation	irritation	NOUN
ajst-405	21	38	to	to	ADP
ajst-405	21	39	the	the	DET
ajst-405	21	40	gastrointestinal	gastrointestinal	ADJ
ajst-405	21	41	tract	tract	NOUN
ajst-405	21	42	,	,	PUNCT
ajst-405	21	43	and	and	CCONJ
ajst-405	21	44	are	be	AUX
ajst-405	21	45	more	more	ADV
ajst-405	21	46	convenient	convenient	ADJ
ajst-405	21	47	for	for	ADP
ajst-405	21	48	rectal	rectal	ADJ
ajst-405	21	49	administration	administration	NOUN
ajst-405	21	50	to	to	ADP
ajst-405	21	51	patients	patient	NOUN
ajst-405	21	52	or	or	CCONJ
ajst-405	21	53	children	child	NOUN
ajst-405	21	54	who	who	PRON
ajst-405	21	55	do	do	AUX
ajst-405	21	56	not	not	PART
ajst-405	21	57	adhere	adhere	VERB
ajst-405	21	58	well	well	ADV
ajst-405	21	59	to	to	ADP
ajst-405	21	60	medication	medication	NOUN
ajst-405	21	61	,	,	PUNCT
ajst-405	21	62	therefore	therefore	ADV
ajst-405	21	63	,	,	PUNCT
ajst-405	21	64	suppositories	suppository	NOUN
ajst-405	21	65	have	have	VERB
ajst-405	21	66	obvious	obvious	ADJ
ajst-405	21	67	advantages	advantage	NOUN
ajst-405	21	68	in	in	ADP
ajst-405	21	69	antipyretic	antipyretic	ADJ
ajst-405	21	70	and	and	CCONJ
ajst-405	21	71	pain	pain	NOUN
ajst-405	21	72	relieving	relieve	VERB
ajst-405	21	73	medication	medication	NOUN
ajst-405	21	74	.	.	PUNCT
ajst-405	22	1	also	also	ADV
ajst-405	22	2	suitable	suitable	ADJ
ajst-405	22	3	for	for	ADP
ajst-405	22	4	non	non	PRON
ajst-405	22	5	oral	oral	ADJ
ajst-405	22	6	drugs	drug	NOUN
ajst-405	22	7	and	and	CCONJ
ajst-405	22	8	other	other	ADJ
ajst-405	22	9	advantages	advantage	NOUN
ajst-405	22	10	,	,	PUNCT
ajst-405	22	11	so	so	SCONJ
ajst-405	22	12	that	that	SCONJ
ajst-405	22	13	suppositories	suppository	NOUN
ajst-405	22	14	play	play	VERB
ajst-405	22	15	a	a	DET
ajst-405	22	16	unique	unique	ADJ
ajst-405	22	17	therapeutic	therapeutic	ADJ
ajst-405	22	18	effect	effect	NOUN
ajst-405	22	19	in	in	ADP
ajst-405	22	20	the	the	DET
ajst-405	22	21	treatment	treatment	NOUN
ajst-405	22	22	of	of	ADP
ajst-405	22	23	luminal	luminal	ADJ
ajst-405	22	24	diseases	disease	NOUN
ajst-405	22	25	,	,	PUNCT
ajst-405	22	26	gynecological	gynecological	ADJ
ajst-405	22	27	diseases	disease	NOUN
ajst-405	22	28	,	,	PUNCT
ajst-405	22	29	rectal	rectal	ADJ
ajst-405	22	30	diseases	disease	NOUN
ajst-405	22	31	.	.	PUNCT
ajst-405	23	1	in	in	ADP
ajst-405	23	2	addition	addition	NOUN
ajst-405	23	3	,	,	PUNCT
ajst-405	23	4	compared	compare	VERB
ajst-405	23	5	with	with	ADP
ajst-405	23	6	oral	oral	ADJ
ajst-405	23	7	or	or	CCONJ
ajst-405	23	8	injectable	injectable	ADJ
ajst-405	23	9	administration	administration	NOUN
ajst-405	23	10	,	,	PUNCT
ajst-405	23	11	the	the	DET
ajst-405	23	12	distribution	distribution	NOUN
ajst-405	23	13	of	of	ADP
ajst-405	23	14	drugs	drug	NOUN
ajst-405	23	15	after	after	SCONJ
ajst-405	23	16	the	the	DET
ajst-405	23	17	administration	administration	NOUN
ajst-405	23	18	of	of	ADP
ajst-405	23	19	suppositories	suppository	NOUN
ajst-405	23	20	is	be	AUX
ajst-405	23	21	more	more	ADV
ajst-405	23	22	concentrated	concentrated	ADJ
ajst-405	23	23	,	,	PUNCT
ajst-405	23	24	the	the	DET
ajst-405	23	25	concentration	concentration	NOUN
ajst-405	23	26	of	of	ADP
ajst-405	23	27	drugs	drug	NOUN
ajst-405	23	28	at	at	ADP
ajst-405	23	29	the	the	DET
ajst-405	23	30	lesion	lesion	NOUN
ajst-405	23	31	site	site	NOUN
ajst-405	23	32	is	be	AUX
ajst-405	23	33	high	high	ADJ
ajst-405	23	34	,	,	PUNCT
ajst-405	23	35	the	the	DET
ajst-405	23	36	efficacy	efficacy	NOUN
ajst-405	23	37	is	be	AUX
ajst-405	23	38	improved	improve	VERB
ajst-405	23	39	,	,	PUNCT
ajst-405	23	40	the	the	DET
ajst-405	23	41	drug	drug	NOUN
ajst-405	23	42	is	be	AUX
ajst-405	23	43	less	less	ADV
ajst-405	23	44	distributed	distribute	VERB
ajst-405	23	45	in	in	ADP
ajst-405	23	46	other	other	ADJ
ajst-405	23	47	sites	site	NOUN
ajst-405	23	48	,	,	PUNCT
ajst-405	23	49	and	and	CCONJ
ajst-405	23	50	its	its	PRON
ajst-405	23	51	adverse	adverse	ADJ
ajst-405	23	52	effects	effect	NOUN
ajst-405	23	53	are	be	AUX
ajst-405	23	54	greatly	greatly	ADV
ajst-405	23	55	reduced	reduce	VERB
ajst-405	23	56	.	.	PUNCT
ajst-405	24	1	2	2	X
ajst-405	24	2	.	.	NUM
ajst-405	24	3	types	type	NOUN
ajst-405	24	4	of	of	ADP
ajst-405	24	5	suppositories	suppository	NOUN
ajst-405	24	6	2.1	2.1	NUM
ajst-405	24	7	.	.	PUNCT
ajst-405	25	1	homogeneous	homogeneous	ADJ
ajst-405	25	2	plain	plain	ADJ
ajst-405	25	3	suppositories	suppository	NOUN
ajst-405	25	4	homogeneous	homogeneous	ADJ
ajst-405	25	5	common	common	ADJ
ajst-405	25	6	suppositories	suppository	NOUN
ajst-405	25	7	the	the	DET
ajst-405	25	8	main	main	ADJ
ajst-405	25	9	ones	one	NOUN
ajst-405	25	10	common	common	ADJ
ajst-405	25	11	according	accord	VERB
ajst-405	25	12	to	to	ADP
ajst-405	25	13	their	their	PRON
ajst-405	25	14	route	route	NOUN
ajst-405	25	15	of	of	ADP
ajst-405	25	16	administration	administration	NOUN
ajst-405	25	17	are	be	AUX
ajst-405	25	18	the	the	DET
ajst-405	25	19	anal	anal	ADJ
ajst-405	25	20	and	and	CCONJ
ajst-405	25	21	vaginal	vaginal	ADJ
ajst-405	25	22	ones	one	NOUN
ajst-405	25	23	.	.	PUNCT
ajst-405	26	1	conotruncal	conotruncal	ADJ
ajst-405	26	2	,	,	PUNCT
ajst-405	26	3	torpedo	torpedo	NOUN
ajst-405	26	4	shaped	shape	VERB
ajst-405	26	5	)	)	PUNCT
ajst-405	26	6	are	be	AUX
ajst-405	26	7	common	common	ADJ
ajst-405	26	8	.	.	PUNCT
ajst-405	27	1	among	among	ADP
ajst-405	27	2	them	they	PRON
ajst-405	27	3	,	,	PUNCT
ajst-405	27	4	those	those	PRON
ajst-405	27	5	with	with	ADP
ajst-405	27	6	torpedo	torpedo	NOUN
ajst-405	27	7	shape	shape	NOUN
ajst-405	27	8	are	be	AUX
ajst-405	27	9	more	more	ADV
ajst-405	27	10	able	able	ADJ
ajst-405	27	11	to	to	PART
ajst-405	27	12	adapt	adapt	VERB
ajst-405	27	13	to	to	ADP
ajst-405	27	14	the	the	DET
ajst-405	27	15	contraction	contraction	NOUN
ajst-405	27	16	of	of	ADP
ajst-405	27	17	the	the	DET
ajst-405	27	18	anal	anal	ADJ
ajst-405	27	19	sphincter	sphincter	NOUN
ajst-405	27	20	and	and	CCONJ
ajst-405	27	21	are	be	AUX
ajst-405	27	22	easily	easily	ADV
ajst-405	27	23	introduced	introduce	VERB
ajst-405	27	24	to	to	ADP
ajst-405	27	25	the	the	DET
ajst-405	27	26	rectum	rectum	NOUN
ajst-405	27	27	.	.	PUNCT
ajst-405	28	1	suppositories	suppository	NOUN
ajst-405	28	2	used	use	VERB
ajst-405	28	3	in	in	ADP
ajst-405	28	4	adults	adult	NOUN
ajst-405	28	5	are	be	AUX
ajst-405	28	6	generally	generally	ADV
ajst-405	28	7	about	about	ADV
ajst-405	28	8	2	2	NUM
ajst-405	28	9	g	g	NOUN
ajst-405	28	10	,	,	PUNCT
ajst-405	28	11	with	with	ADP
ajst-405	28	12	a	a	DET
ajst-405	28	13	length	length	NOUN
ajst-405	28	14	of	of	ADP
ajst-405	28	15	3	3	NUM
ajst-405	28	16	to	to	PART
ajst-405	28	17	4	4	NUM
ajst-405	28	18	cm	cm	NOUN
ajst-405	28	19	,	,	PUNCT
ajst-405	28	20	and	and	CCONJ
ajst-405	28	21	in	in	ADP
ajst-405	28	22	children	child	NOUN
ajst-405	28	23	about	about	ADV
ajst-405	28	24	1	1	NUM
ajst-405	28	25	g	g	NOUN
ajst-405	28	26	,	,	PUNCT
ajst-405	28	27	reduced	reduce	VERB
ajst-405	28	28	as	as	ADP
ajst-405	28	29	appropriate	appropriate	ADJ
ajst-405	28	30	for	for	ADP
ajst-405	28	31	age	age	NOUN
ajst-405	28	32	;	;	PUNCT
ajst-405	28	33	the	the	DET
ajst-405	28	34	shape	shape	NOUN
ajst-405	28	35	of	of	ADP
ajst-405	28	36	the	the	DET
ajst-405	28	37	vaginal	vaginal	ADJ
ajst-405	28	38	plug	plug	NOUN
ajst-405	28	39	was	be	AUX
ajst-405	28	40	mainly	mainly	ADV
ajst-405	28	41	spherical	spherical	ADJ
ajst-405	28	42	,	,	PUNCT
ajst-405	28	43	ovoid	ovoid	ADJ
ajst-405	28	44	,	,	PUNCT
ajst-405	28	45	duckbill	duckbill	NOUN
ajst-405	28	46	and	and	CCONJ
ajst-405	28	47	fusiform	fusiform	NOUN
ajst-405	28	48	,	,	PUNCT
ajst-405	28	49	and	and	CCONJ
ajst-405	28	50	each	each	DET
ajst-405	28	51	plug	plug	NOUN
ajst-405	28	52	weighed	weigh	VERB
ajst-405	28	53	2	2	NUM
ajst-405	28	54	-	-	SYM
ajst-405	28	55	5	5	NUM
ajst-405	28	56	g	g	NOUN
ajst-405	28	57	and	and	CCONJ
ajst-405	28	58	measured	measure	VERB
ajst-405	28	59	1.5	1.5	NUM
ajst-405	28	60	-	-	SYM
ajst-405	28	61	2.5	2.5	NUM
ajst-405	28	62	cm	cm	NOUN
ajst-405	28	63	in	in	ADP
ajst-405	28	64	diameter	diameter	NOUN
ajst-405	28	65	.	.	PUNCT
ajst-405	29	1	other	other	ADJ
ajst-405	29	2	suppository	suppository	ADJ
ajst-405	29	3	types	type	NOUN
ajst-405	29	4	are	be	AUX
ajst-405	29	5	urethral	urethral	ADJ
ajst-405	29	6	plugs	plug	NOUN
ajst-405	29	7	,	,	PUNCT
ajst-405	29	8	nasal	nasal	ADJ
ajst-405	29	9	plugs	plug	NOUN
ajst-405	29	10	,	,	PUNCT
ajst-405	29	11	ear	ear	X
ajst-405	29	12	plugs	plug	NOUN
ajst-405	29	13	,	,	PUNCT
ajst-405	29	14	etc	etc	X
ajst-405	29	15	.	.	X
ajst-405	30	1	[	[	X
ajst-405	30	2	4	4	NUM
ajst-405	30	3	]	]	PUNCT
ajst-405	30	4	.	.	PUNCT
ajst-405	31	1	2.2	2.2	NUM
ajst-405	31	2	.	.	PUNCT
ajst-405	31	3	double	double	ADJ
ajst-405	31	4	layered	layered	ADJ
ajst-405	31	5	plugs	plug	NOUN
ajst-405	31	6	common	common	ADJ
ajst-405	31	7	single	single	ADJ
ajst-405	31	8	-	-	PUNCT
ajst-405	31	9	layer	layer	NOUN
ajst-405	31	10	suppositories	suppository	NOUN
ajst-405	31	11	will	will	AUX
ajst-405	31	12	move	move	VERB
ajst-405	31	13	deep	deep	ADV
ajst-405	31	14	to	to	ADP
ajst-405	31	15	the	the	DET
ajst-405	31	16	administration	administration	NOUN
ajst-405	31	17	site	site	NOUN
ajst-405	31	18	upon	upon	SCONJ
ajst-405	31	19	fusion	fusion	NOUN
ajst-405	31	20	,	,	PUNCT
ajst-405	31	21	and	and	CCONJ
ajst-405	31	22	deep	deep	ADJ
ajst-405	31	23	drugs	drug	NOUN
ajst-405	31	24	enter	enter	VERB
ajst-405	31	25	the	the	DET
ajst-405	31	26	liver	liver	NOUN
ajst-405	31	27	via	via	ADP
ajst-405	31	28	the	the	DET
ajst-405	31	29	rectum	rectum	NOUN
ajst-405	31	30	after	after	ADP
ajst-405	31	31	being	be	AUX
ajst-405	31	32	absorbed	absorb	VERB
ajst-405	31	33	intravenously	intravenously	ADV
ajst-405	31	34	,	,	PUNCT
ajst-405	31	35	thus	thus	ADV
ajst-405	31	36	having	have	VERB
ajst-405	31	37	a	a	DET
ajst-405	31	38	first	first	ADJ
ajst-405	31	39	pass	pass	NOUN
ajst-405	31	40	effect	effect	NOUN
ajst-405	31	41	,	,	PUNCT
ajst-405	31	42	affecting	affect	VERB
ajst-405	31	43	the	the	DET
ajst-405	31	44	bioavailability	bioavailability	NOUN
ajst-405	31	45	of	of	ADP
ajst-405	31	46	drugs	drug	NOUN
ajst-405	31	47	.	.	PUNCT
ajst-405	32	1	in	in	ADP
ajst-405	32	2	order	order	NOUN
ajst-405	32	3	to	to	PART
ajst-405	32	4	allow	allow	VERB
ajst-405	32	5	the	the	DET
ajst-405	32	6	effective	effective	ADJ
ajst-405	32	7	absorption	absorption	NOUN
ajst-405	32	8	of	of	ADP
ajst-405	32	9	suppository	suppository	ADJ
ajst-405	32	10	drugs	drug	NOUN
ajst-405	32	11	in	in	ADP
ajst-405	32	12	the	the	DET
ajst-405	32	13	lower	low	ADJ
ajst-405	32	14	rectal	rectal	ADJ
ajst-405	32	15	vein	vein	NOUN
ajst-405	32	16	,	,	PUNCT
ajst-405	32	17	a	a	DET
ajst-405	32	18	double	double	ADJ
ajst-405	32	19	layered	layered	ADJ
ajst-405	32	20	suppository	suppository	NOUN
ajst-405	32	21	composed	compose	VERB
ajst-405	32	22	of	of	ADP
ajst-405	32	23	a	a	DET
ajst-405	32	24	water	water	NOUN
ajst-405	32	25	-	-	PUNCT
ajst-405	32	26	soluble	soluble	ADJ
ajst-405	32	27	matrix	matrix	NOUN
ajst-405	32	28	plug	plug	NOUN
ajst-405	32	29	(	(	PUNCT
ajst-405	32	30	intrarectal	intrarectal	ADJ
ajst-405	32	31	absorption	absorption	NOUN
ajst-405	32	32	of	of	ADP
ajst-405	32	33	secretory	secretory	ADJ
ajst-405	32	34	fluid	fluid	NOUN
ajst-405	32	35	to	to	PART
ajst-405	32	36	form	form	VERB
ajst-405	32	37	a	a	DET
ajst-405	32	38	gel	gel	NOUN
ajst-405	32	39	to	to	PART
ajst-405	32	40	inhibit	inhibit	VERB
ajst-405	32	41	the	the	DET
ajst-405	32	42	diffusion	diffusion	NOUN
ajst-405	32	43	of	of	ADP
ajst-405	32	44	drugs	drug	NOUN
ajst-405	32	45	from	from	ADP
ajst-405	32	46	the	the	DET
ajst-405	32	47	lower	low	ADJ
ajst-405	32	48	rectum	rectum	NOUN
ajst-405	32	49	to	to	ADP
ajst-405	32	50	the	the	DET
ajst-405	32	51	upper	upper	ADJ
ajst-405	32	52	part	part	NOUN
ajst-405	32	53	)	)	PUNCT
ajst-405	32	54	together	together	ADV
ajst-405	32	55	with	with	ADP
ajst-405	32	56	a	a	DET
ajst-405	32	57	drug	drug	NOUN
ajst-405	32	58	containing	contain	VERB
ajst-405	32	59	plug	plug	NOUN
ajst-405	32	60	was	be	AUX
ajst-405	32	61	designed	design	VERB
ajst-405	32	62	.	.	PUNCT
ajst-405	33	1	41	41	NUM
ajst-405	34	1	the	the	DET
ajst-405	34	2	characteristics	characteristic	NOUN
ajst-405	34	3	can	can	AUX
ajst-405	34	4	be	be	AUX
ajst-405	34	5	classified	classify	VERB
ajst-405	34	6	as	as	SCONJ
ajst-405	34	7	follows	follow	VERB
ajst-405	34	8	:	:	PUNCT
ajst-405	34	9	dispersing	disperse	VERB
ajst-405	34	10	two	two	NUM
ajst-405	34	11	or	or	CCONJ
ajst-405	34	12	more	more	ADJ
ajst-405	34	13	drugs	drug	NOUN
ajst-405	34	14	with	with	ADP
ajst-405	34	15	different	different	ADJ
ajst-405	34	16	physicochemical	physicochemical	ADJ
ajst-405	34	17	properties	property	NOUN
ajst-405	34	18	into	into	ADP
ajst-405	34	19	a	a	DET
ajst-405	34	20	lipid	lipid	ADJ
ajst-405	34	21	soluble	soluble	ADJ
ajst-405	34	22	mechanism	mechanism	NOUN
ajst-405	34	23	or	or	CCONJ
ajst-405	34	24	a	a	DET
ajst-405	34	25	water	water	NOUN
ajst-405	34	26	-	-	PUNCT
ajst-405	34	27	soluble	soluble	ADJ
ajst-405	34	28	mechanism	mechanism	NOUN
ajst-405	34	29	,	,	PUNCT
ajst-405	34	30	respectively	respectively	ADV
ajst-405	34	31	,	,	PUNCT
ajst-405	34	32	to	to	PART
ajst-405	34	33	make	make	VERB
ajst-405	34	34	suppositories	suppository	NOUN
ajst-405	34	35	containing	contain	VERB
ajst-405	34	36	upper	upper	ADJ
ajst-405	34	37	and	and	CCONJ
ajst-405	34	38	lower	low	ADJ
ajst-405	34	39	two	two	NUM
ajst-405	34	40	layers	layer	NOUN
ajst-405	34	41	,	,	PUNCT
ajst-405	34	42	facilitating	facilitate	VERB
ajst-405	34	43	drug	drug	NOUN
ajst-405	34	44	absorption	absorption	NOUN
ajst-405	34	45	or	or	CCONJ
ajst-405	34	46	avoiding	avoid	VERB
ajst-405	34	47	compatibility	compatibility	NOUN
ajst-405	34	48	contraindications	contraindication	NOUN
ajst-405	34	49	that	that	PRON
ajst-405	34	50	may	may	AUX
ajst-405	34	51	occur	occur	VERB
ajst-405	34	52	with	with	ADP
ajst-405	34	53	drugs	drug	NOUN
ajst-405	34	54	;	;	PUNCT
ajst-405	34	55	the	the	DET
ajst-405	34	56	upper	upper	ADJ
ajst-405	34	57	and	and	CCONJ
ajst-405	34	58	lower	low	ADJ
ajst-405	34	59	layers	layer	NOUN
ajst-405	34	60	were	be	AUX
ajst-405	34	61	made	make	VERB
ajst-405	34	62	with	with	ADP
ajst-405	34	63	blank	blank	ADJ
ajst-405	34	64	matrix	matrix	NOUN
ajst-405	34	65	and	and	CCONJ
ajst-405	34	66	drug	drug	NOUN
ajst-405	34	67	containing	contain	VERB
ajst-405	34	68	matrix	matrix	NOUN
ajst-405	34	69	,	,	PUNCT
ajst-405	34	70	and	and	CCONJ
ajst-405	34	71	the	the	DET
ajst-405	34	72	upper	upper	ADJ
ajst-405	34	73	layer	layer	NOUN
ajst-405	34	74	of	of	ADP
ajst-405	34	75	blank	blank	ADJ
ajst-405	34	76	matrix	matrix	NOUN
ajst-405	34	77	was	be	AUX
ajst-405	34	78	utilized	utilize	VERB
ajst-405	34	79	to	to	PART
ajst-405	34	80	block	block	VERB
ajst-405	34	81	the	the	DET
ajst-405	34	82	upward	upward	ADJ
ajst-405	34	83	diffusion	diffusion	NOUN
ajst-405	34	84	of	of	ADP
ajst-405	34	85	drugs	drug	NOUN
ajst-405	34	86	,	,	PUNCT
ajst-405	34	87	so	so	SCONJ
ajst-405	34	88	as	as	SCONJ
ajst-405	34	89	to	to	PART
ajst-405	34	90	reduce	reduce	VERB
ajst-405	34	91	the	the	DET
ajst-405	34	92	drug	drug	NOUN
ajst-405	34	93	absorption	absorption	NOUN
ajst-405	34	94	from	from	ADP
ajst-405	34	95	the	the	DET
ajst-405	34	96	superior	superior	ADJ
ajst-405	34	97	rectal	rectal	ADJ
ajst-405	34	98	vena	vena	NOUN
ajst-405	34	99	cava	cava	NOUN
ajst-405	34	100	,	,	PUNCT
ajst-405	34	101	in	in	ADP
ajst-405	34	102	order	order	NOUN
ajst-405	34	103	to	to	PART
ajst-405	34	104	improve	improve	VERB
ajst-405	34	105	the	the	DET
ajst-405	34	106	drug	drug	NOUN
ajst-405	34	107	availability	availability	NOUN
ajst-405	34	108	and	and	CCONJ
ajst-405	34	109	reduce	reduce	VERB
ajst-405	34	110	the	the	DET
ajst-405	34	111	adverse	adverse	ADJ
ajst-405	34	112	effects	effect	NOUN
ajst-405	34	113	of	of	ADP
ajst-405	34	114	drugs	drug	NOUN
ajst-405	34	115	;	;	PUNCT
ajst-405	34	116	a	a	DET
ajst-405	34	117	drug	drug	NOUN
ajst-405	34	118	is	be	AUX
ajst-405	34	119	prepared	prepare	VERB
ajst-405	34	120	as	as	ADP
ajst-405	34	121	upper	upper	ADJ
ajst-405	34	122	and	and	CCONJ
ajst-405	34	123	lower	low	ADJ
ajst-405	34	124	two	two	NUM
ajst-405	34	125	layers	layer	NOUN
ajst-405	34	126	by	by	ADP
ajst-405	34	127	dispersing	disperse	VERB
ajst-405	34	128	in	in	ADP
ajst-405	34	129	a	a	DET
ajst-405	34	130	lipid	lipid	ADJ
ajst-405	34	131	soluble	soluble	ADJ
ajst-405	34	132	matrix	matrix	NOUN
ajst-405	34	133	and	and	CCONJ
ajst-405	34	134	a	a	DET
ajst-405	34	135	water	water	NOUN
ajst-405	34	136	-	-	PUNCT
ajst-405	34	137	soluble	soluble	ADJ
ajst-405	34	138	matrix	matrix	NOUN
ajst-405	34	139	,	,	PUNCT
ajst-405	34	140	respectively	respectively	ADV
ajst-405	34	141	,	,	PUNCT
ajst-405	34	142	which	which	PRON
ajst-405	34	143	enables	enable	VERB
ajst-405	34	144	suppositories	suppository	NOUN
ajst-405	34	145	to	to	PART
ajst-405	34	146	have	have	VERB
ajst-405	34	147	both	both	CCONJ
ajst-405	34	148	immediate	immediate	ADJ
ajst-405	34	149	and	and	CCONJ
ajst-405	34	150	sustained	sustained	ADJ
ajst-405	34	151	release	release	NOUN
ajst-405	34	152	effects	effect	NOUN
ajst-405	34	153	when	when	SCONJ
ajst-405	34	154	used	use	VERB
ajst-405	34	155	;	;	PUNCT
ajst-405	34	156	suppositories	suppository	NOUN
ajst-405	34	157	from	from	ADP
ajst-405	34	158	the	the	DET
ajst-405	34	159	inner	inner	ADJ
ajst-405	34	160	and	and	CCONJ
ajst-405	34	161	outer	outer	ADJ
ajst-405	34	162	bilayers	bilayer	NOUN
ajst-405	34	163	,	,	PUNCT
ajst-405	34	164	since	since	SCONJ
ajst-405	34	165	the	the	DET
ajst-405	34	166	outer	outer	ADJ
ajst-405	34	167	layer	layer	NOUN
ajst-405	34	168	first	first	ADV
ajst-405	34	169	dissolves	dissolve	VERB
ajst-405	34	170	and	and	CCONJ
ajst-405	34	171	then	then	ADV
ajst-405	34	172	the	the	DET
ajst-405	34	173	inner	inner	ADJ
ajst-405	34	174	layer	layer	NOUN
ajst-405	34	175	dissolves	dissolve	VERB
ajst-405	34	176	and	and	CCONJ
ajst-405	34	177	fuses	fuse	NOUN
ajst-405	34	178	,	,	PUNCT
ajst-405	34	179	can	can	AUX
ajst-405	34	180	exert	exert	VERB
ajst-405	34	181	the	the	DET
ajst-405	34	182	effects	effect	NOUN
ajst-405	34	183	of	of	ADP
ajst-405	34	184	both	both	DET
ajst-405	34	185	drugs	drug	NOUN
ajst-405	34	186	.	.	PUNCT
ajst-405	35	1	qiu	qiu	PROPN
ajst-405	35	2	gui	gui	PROPN
ajst-405	35	3	zhou	zhou	PROPN
ajst-405	35	4	et	et	PROPN
ajst-405	35	5	al	al	PROPN
ajst-405	36	1	[	[	X
ajst-405	36	2	5	5	NUM
ajst-405	36	3	]	]	X
ajst-405	36	4	prepared	prepare	VERB
ajst-405	36	5	the	the	DET
ajst-405	36	6	lower	low	ADJ
ajst-405	36	7	pharmaceutical	pharmaceutical	ADJ
ajst-405	36	8	layer	layer	NOUN
ajst-405	36	9	of	of	ADP
ajst-405	36	10	aspirin	aspirin	NOUN
ajst-405	36	11	bilayer	bilayer	NOUN
ajst-405	36	12	suppositories	suppository	NOUN
ajst-405	36	13	by	by	ADP
ajst-405	36	14	mixing	mix	VERB
ajst-405	36	15	fatty	fatty	NOUN
ajst-405	36	16	acid	acid	NOUN
ajst-405	36	17	glycerolipids	glycerolipid	NOUN
ajst-405	36	18	with	with	ADP
ajst-405	36	19	lipid	lipid	ADJ
ajst-405	36	20	soluble	soluble	ADJ
ajst-405	36	21	matrix	matrix	NOUN
ajst-405	36	22	,	,	PUNCT
ajst-405	36	23	and	and	CCONJ
ajst-405	36	24	the	the	DET
ajst-405	36	25	upper	upper	ADJ
ajst-405	36	26	blank	blank	ADJ
ajst-405	36	27	layer	layer	NOUN
ajst-405	36	28	of	of	ADP
ajst-405	36	29	aspirin	aspirin	NOUN
ajst-405	36	30	bilayer	bilayer	NOUN
ajst-405	36	31	suppositories	suppository	NOUN
ajst-405	36	32	was	be	AUX
ajst-405	36	33	prepared	prepare	VERB
ajst-405	36	34	with	with	ADP
ajst-405	36	35	water	water	NOUN
ajst-405	36	36	-	-	PUNCT
ajst-405	36	37	soluble	soluble	ADJ
ajst-405	36	38	matrix	matrix	NOUN
ajst-405	36	39	.	.	PUNCT
ajst-405	37	1	effectively	effectively	ADV
ajst-405	37	2	prevent	prevent	VERB
ajst-405	37	3	the	the	DET
ajst-405	37	4	upward	upward	ADJ
ajst-405	37	5	diffusion	diffusion	NOUN
ajst-405	37	6	of	of	ADP
ajst-405	37	7	drugs	drug	NOUN
ajst-405	37	8	released	release	VERB
ajst-405	37	9	from	from	ADP
ajst-405	37	10	traditional	traditional	ADJ
ajst-405	37	11	aspirin	aspirin	NOUN
ajst-405	37	12	anal	anal	ADJ
ajst-405	37	13	suppositories	suppository	NOUN
ajst-405	37	14	,	,	PUNCT
ajst-405	37	15	avoid	avoid	VERB
ajst-405	37	16	the	the	DET
ajst-405	37	17	absorption	absorption	NOUN
ajst-405	37	18	of	of	ADP
ajst-405	37	19	some	some	DET
ajst-405	37	20	drugs	drug	NOUN
ajst-405	37	21	through	through	ADP
ajst-405	37	22	the	the	DET
ajst-405	37	23	portal	portal	ADJ
ajst-405	37	24	hepatic	hepatic	ADJ
ajst-405	37	25	system	system	NOUN
ajst-405	37	26	,	,	PUNCT
ajst-405	37	27	and	and	CCONJ
ajst-405	37	28	improve	improve	VERB
ajst-405	37	29	the	the	DET
ajst-405	37	30	bioavailability	bioavailability	NOUN
ajst-405	37	31	of	of	ADP
ajst-405	37	32	aspirin	aspirin	NOUN
ajst-405	37	33	.	.	PUNCT
ajst-405	38	1	household	household	PROPN
ajst-405	38	2	juan	juan	PROPN
ajst-405	38	3	zhang	zhang	PROPN
ajst-405	39	1	[	[	X
ajst-405	39	2	6	6	NUM
ajst-405	39	3	]	]	X
ajst-405	39	4	prepared	prepare	VERB
ajst-405	39	5	as	as	ADP
ajst-405	39	6	double	double	ADJ
ajst-405	39	7	layered	layered	ADJ
ajst-405	39	8	suppositories	suppository	NOUN
ajst-405	39	9	by	by	ADP
ajst-405	39	10	using	use	VERB
ajst-405	39	11	bitter	bitter	ADJ
ajst-405	39	12	bean	bean	NOUN
ajst-405	39	13	extracts	extract	NOUN
ajst-405	39	14	for	for	ADP
ajst-405	39	15	local	local	ADJ
ajst-405	39	16	vaginal	vaginal	ADJ
ajst-405	39	17	delivery	delivery	NOUN
ajst-405	39	18	,	,	PUNCT
ajst-405	39	19	and	and	CCONJ
ajst-405	39	20	used	use	VERB
ajst-405	39	21	the	the	DET
ajst-405	39	22	slow	slow	ADJ
ajst-405	39	23	-	-	PUNCT
ajst-405	39	24	release	release	NOUN
ajst-405	39	25	characteristics	characteristic	NOUN
ajst-405	39	26	of	of	ADP
ajst-405	39	27	double	double	ADJ
ajst-405	39	28	layered	layered	ADJ
ajst-405	39	29	suppositories	suppository	NOUN
ajst-405	39	30	to	to	PART
ajst-405	39	31	prolong	prolong	VERB
ajst-405	39	32	the	the	DET
ajst-405	39	33	retention	retention	NOUN
ajst-405	39	34	time	time	NOUN
ajst-405	39	35	of	of	ADP
ajst-405	39	36	drugs	drug	NOUN
ajst-405	39	37	and	and	CCONJ
ajst-405	39	38	exert	exert	VERB
ajst-405	39	39	long	long	ADV
ajst-405	39	40	-	-	PUNCT
ajst-405	39	41	lasting	last	VERB
ajst-405	39	42	and	and	CCONJ
ajst-405	39	43	stable	stable	ADJ
ajst-405	39	44	drug	drug	NOUN
ajst-405	39	45	effects	effect	NOUN
ajst-405	39	46	,	,	PUNCT
ajst-405	39	47	in	in	ADP
ajst-405	39	48	the	the	DET
ajst-405	39	49	hope	hope	NOUN
ajst-405	39	50	of	of	ADP
ajst-405	39	51	providing	provide	VERB
ajst-405	39	52	a	a	DET
ajst-405	39	53	safe	safe	ADJ
ajst-405	39	54	and	and	CCONJ
ajst-405	39	55	long	long	ADV
ajst-405	39	56	-	-	PUNCT
ajst-405	39	57	acting	act	VERB
ajst-405	39	58	new	new	ADJ
ajst-405	39	59	double	double	ADJ
ajst-405	39	60	layered	layered	ADJ
ajst-405	39	61	suppository	suppository	NOUN
ajst-405	39	62	for	for	ADP
ajst-405	39	63	the	the	DET
ajst-405	39	64	treatment	treatment	NOUN
ajst-405	39	65	of	of	ADP
ajst-405	39	66	gynecological	gynecological	ADJ
ajst-405	39	67	inflammation	inflammation	NOUN
ajst-405	39	68	.	.	PUNCT
ajst-405	40	1	2.3	2.3	NUM
ajst-405	40	2	.	.	PUNCT
ajst-405	41	1	hollow	hollow	ADJ
ajst-405	41	2	plugs	plug	NOUN
ajst-405	41	3	with	with	ADP
ajst-405	41	4	the	the	DET
ajst-405	41	5	development	development	NOUN
ajst-405	41	6	of	of	ADP
ajst-405	41	7	suppositories	suppository	NOUN
ajst-405	41	8	,	,	PUNCT
ajst-405	41	9	tandou	tandou	PROPN
ajst-405	41	10	shanfeng	shanfeng	PROPN
ajst-405	41	11	et	et	PROPN
ajst-405	41	12	al	al	PROPN
ajst-405	41	13	developed	develop	VERB
ajst-405	41	14	hollow	hollow	ADJ
ajst-405	41	15	suppositories	suppository	NOUN
ajst-405	41	16	(	(	PUNCT
ajst-405	41	17	hts	ht	NOUN
ajst-405	41	18	)	)	PUNCT
ajst-405	41	19	in	in	ADP
ajst-405	41	20	1984	1984	NUM
ajst-405	41	21	,	,	PUNCT
ajst-405	41	22	whose	whose	DET
ajst-405	41	23	outer	outer	ADJ
ajst-405	41	24	layer	layer	NOUN
ajst-405	41	25	is	be	AUX
ajst-405	41	26	a	a	DET
ajst-405	41	27	shell	shell	NOUN
ajst-405	41	28	made	make	VERB
ajst-405	41	29	of	of	ADP
ajst-405	41	30	matrix	matrix	NOUN
ajst-405	41	31	and	and	CCONJ
ajst-405	41	32	hollow	hollow	NOUN
ajst-405	41	33	can	can	AUX
ajst-405	41	34	be	be	AUX
ajst-405	41	35	filled	fill	VERB
ajst-405	41	36	with	with	ADP
ajst-405	41	37	drugs	drug	NOUN
ajst-405	41	38	in	in	ADP
ajst-405	41	39	various	various	ADJ
ajst-405	41	40	states	state	NOUN
ajst-405	41	41	such	such	ADJ
ajst-405	41	42	as	as	ADP
ajst-405	41	43	solid	solid	ADJ
ajst-405	41	44	,	,	PUNCT
ajst-405	41	45	liquid	liquid	ADJ
ajst-405	41	46	and	and	CCONJ
ajst-405	41	47	suspended	suspend	VERB
ajst-405	41	48	states	state	NOUN
ajst-405	41	49	,	,	PUNCT
ajst-405	41	50	hts	hts	PROPN
ajst-405	41	51	offers	offer	VERB
ajst-405	41	52	the	the	DET
ajst-405	41	53	possibility	possibility	NOUN
ajst-405	41	54	of	of	ADP
ajst-405	41	55	rectal	rectal	ADJ
ajst-405	41	56	drug	drug	NOUN
ajst-405	41	57	delivery	delivery	NOUN
ajst-405	41	58	for	for	ADP
ajst-405	41	59	many	many	ADJ
ajst-405	41	60	drugs	drug	NOUN
ajst-405	41	61	due	due	ADP
ajst-405	41	62	to	to	ADP
ajst-405	41	63	its	its	PRON
ajst-405	41	64	rapid	rapid	ADJ
ajst-405	41	65	drug	drug	NOUN
ajst-405	41	66	release	release	NOUN
ajst-405	41	67	,	,	PUNCT
ajst-405	41	68	high	high	ADJ
ajst-405	41	69	bioavailability	bioavailability	NOUN
ajst-405	41	70	and	and	CCONJ
ajst-405	41	71	wide	wide	ADJ
ajst-405	41	72	application	application	NOUN
ajst-405	41	73	range	range	NOUN
ajst-405	41	74	compared	compare	VERB
ajst-405	41	75	with	with	ADP
ajst-405	41	76	common	common	ADJ
ajst-405	41	77	suppositories	suppository	NOUN
ajst-405	41	78	.	.	PUNCT
ajst-405	42	1	hollow	hollow	ADJ
ajst-405	42	2	plugs	plug	NOUN
ajst-405	42	3	for	for	ADP
ajst-405	42	4	rectal	rectal	ADJ
ajst-405	42	5	drug	drug	NOUN
ajst-405	42	6	delivery	delivery	NOUN
ajst-405	42	7	improve	improve	VERB
ajst-405	42	8	systemic	systemic	ADJ
ajst-405	42	9	effectiveness	effectiveness	NOUN
ajst-405	42	10	.	.	PUNCT
ajst-405	43	1	previous	previous	ADJ
ajst-405	43	2	data	datum	NOUN
ajst-405	43	3	of	of	ADP
ajst-405	43	4	bioavailability	bioavailability	NOUN
ajst-405	43	5	indicated	indicate	VERB
ajst-405	43	6	that	that	SCONJ
ajst-405	43	7	hollow	hollow	ADJ
ajst-405	43	8	type	type	NOUN
ajst-405	43	9	suppositories	suppository	NOUN
ajst-405	43	10	were	be	AUX
ajst-405	43	11	more	more	ADV
ajst-405	43	12	effective	effective	ADJ
ajst-405	43	13	for	for	ADP
ajst-405	43	14	the	the	DET
ajst-405	43	15	absorption	absorption	NOUN
ajst-405	43	16	of	of	ADP
ajst-405	43	17	part	part	NOUN
ajst-405	43	18	of	of	ADP
ajst-405	43	19	the	the	DET
ajst-405	43	20	drug	drug	NOUN
ajst-405	43	21	compared	compare	VERB
ajst-405	43	22	with	with	ADP
ajst-405	43	23	conventional	conventional	ADJ
ajst-405	43	24	suppositories	suppository	NOUN
ajst-405	43	25	.	.	PUNCT
ajst-405	44	1	haiyu	haiyu	PROPN
ajst-405	44	2	pan	pan	PROPN
ajst-405	45	1	[	[	X
ajst-405	45	2	7	7	NUM
ajst-405	45	3	]	]	PUNCT
ajst-405	45	4	and	and	CCONJ
ajst-405	45	5	others	other	NOUN
ajst-405	45	6	prepare	prepare	VERB
ajst-405	45	7	nimesulide	nimesulide	ADV
ajst-405	45	8	into	into	ADP
ajst-405	45	9	a	a	DET
ajst-405	45	10	hollow	hollow	ADJ
ajst-405	45	11	suppository	suppository	NOUN
ajst-405	45	12	so	so	SCONJ
ajst-405	45	13	that	that	SCONJ
ajst-405	45	14	it	it	PRON
ajst-405	45	15	can	can	AUX
ajst-405	45	16	quickly	quickly	ADV
ajst-405	45	17	reach	reach	VERB
ajst-405	45	18	the	the	DET
ajst-405	45	19	effective	effective	ADJ
ajst-405	45	20	blood	blood	NOUN
ajst-405	45	21	drug	drug	NOUN
ajst-405	45	22	concentration	concentration	NOUN
ajst-405	45	23	and	and	CCONJ
ajst-405	45	24	maintain	maintain	VERB
ajst-405	45	25	the	the	DET
ajst-405	45	26	concentration	concentration	NOUN
ajst-405	45	27	for	for	ADP
ajst-405	45	28	a	a	DET
ajst-405	45	29	long	long	ADJ
ajst-405	45	30	time	time	NOUN
ajst-405	45	31	,	,	PUNCT
ajst-405	45	32	indicating	indicate	VERB
ajst-405	45	33	that	that	SCONJ
ajst-405	45	34	this	this	DET
ajst-405	45	35	hollow	hollow	ADJ
ajst-405	45	36	suppository	suppository	NOUN
ajst-405	45	37	not	not	PART
ajst-405	45	38	only	only	ADV
ajst-405	45	39	enables	enable	VERB
ajst-405	45	40	the	the	DET
ajst-405	45	41	rapid	rapid	ADJ
ajst-405	45	42	onset	onset	NOUN
ajst-405	45	43	of	of	ADP
ajst-405	45	44	drugs	drug	NOUN
ajst-405	45	45	and	and	CCONJ
ajst-405	45	46	maintains	maintain	VERB
ajst-405	45	47	the	the	DET
ajst-405	45	48	treatment	treatment	NOUN
ajst-405	45	49	for	for	ADP
ajst-405	45	50	a	a	DET
ajst-405	45	51	longer	long	ADJ
ajst-405	45	52	time	time	NOUN
ajst-405	45	53	,	,	PUNCT
ajst-405	45	54	but	but	CCONJ
ajst-405	45	55	also	also	ADV
ajst-405	45	56	has	have	VERB
ajst-405	45	57	a	a	DET
ajst-405	45	58	slower	slow	ADJ
ajst-405	45	59	peak	peak	NOUN
ajst-405	45	60	blood	blood	NOUN
ajst-405	45	61	concentration	concentration	NOUN
ajst-405	45	62	and	and	CCONJ
ajst-405	45	63	reduces	reduce	VERB
ajst-405	45	64	drug	drug	NOUN
ajst-405	45	65	toxic	toxic	ADJ
ajst-405	45	66	side	side	NOUN
ajst-405	45	67	effects	effect	NOUN
ajst-405	45	68	.	.	PUNCT
ajst-405	46	1	peng	peng	PROPN
ajst-405	46	2	hao	hao	PROPN
ajst-405	46	3	chen	chen	PROPN
ajst-405	46	4	et	et	PROPN
ajst-405	46	5	al	al	PROPN
ajst-405	47	1	[	[	X
ajst-405	47	2	8	8	NUM
ajst-405	47	3	]	]	PUNCT
ajst-405	47	4	used	use	VERB
ajst-405	47	5	commercially	commercially	ADV
ajst-405	47	6	available	available	ADJ
ajst-405	47	7	pediatric	pediatric	ADJ
ajst-405	47	8	ibuprofen	ibuprofen	NOUN
ajst-405	47	9	plugs	plug	NOUN
ajst-405	47	10	as	as	ADP
ajst-405	47	11	a	a	DET
ajst-405	47	12	control	control	NOUN
ajst-405	47	13	to	to	PART
ajst-405	47	14	investigate	investigate	VERB
ajst-405	47	15	the	the	DET
ajst-405	47	16	in	in	X
ajst-405	47	17	vitro	vitro	X
ajst-405	47	18	dissolution	dissolution	NOUN
ajst-405	47	19	of	of	ADP
ajst-405	47	20	the	the	DET
ajst-405	47	21	self	self	NOUN
ajst-405	47	22	-	-	PUNCT
ajst-405	47	23	made	make	VERB
ajst-405	47	24	hollow	hollow	ADJ
ajst-405	47	25	plugs	plug	NOUN
ajst-405	47	26	.	.	PUNCT
ajst-405	48	1	the	the	DET
ajst-405	48	2	results	result	NOUN
ajst-405	48	3	showed	show	VERB
ajst-405	48	4	that	that	SCONJ
ajst-405	48	5	both	both	DET
ajst-405	48	6	hollow	hollow	ADJ
ajst-405	48	7	plugs	plug	NOUN
ajst-405	48	8	reached	reach	VERB
ajst-405	48	9	dissolution	dissolution	ADJ
ajst-405	48	10	equilibrium	equilibrium	NOUN
ajst-405	48	11	within	within	ADP
ajst-405	48	12	20	20	NUM
ajst-405	48	13	min	min	NOUN
ajst-405	48	14	with	with	ADP
ajst-405	48	15	dissolution	dissolution	NOUN
ajst-405	48	16	rates	rate	NOUN
ajst-405	48	17	greater	great	ADJ
ajst-405	48	18	than	than	ADP
ajst-405	48	19	90	90	NUM
ajst-405	48	20	%	%	NOUN
ajst-405	48	21	;	;	PUNCT
ajst-405	48	22	however	however	ADV
ajst-405	48	23	,	,	PUNCT
ajst-405	48	24	the	the	DET
ajst-405	48	25	dissolution	dissolution	NOUN
ajst-405	48	26	rate	rate	NOUN
ajst-405	48	27	was	be	AUX
ajst-405	48	28	79	79	NUM
ajst-405	48	29	%	%	NOUN
ajst-405	48	30	at	at	ADP
ajst-405	48	31	70	70	NUM
ajst-405	48	32	min	min	NOUN
ajst-405	48	33	,	,	PUNCT
ajst-405	48	34	which	which	PRON
ajst-405	48	35	suggested	suggest	VERB
ajst-405	48	36	that	that	SCONJ
ajst-405	48	37	the	the	DET
ajst-405	48	38	hollow	hollow	ADJ
ajst-405	48	39	plug	plug	NOUN
ajst-405	48	40	could	could	AUX
ajst-405	48	41	achieve	achieve	VERB
ajst-405	48	42	rapid	rapid	ADJ
ajst-405	48	43	drug	drug	NOUN
ajst-405	48	44	release	release	NOUN
ajst-405	48	45	.	.	PUNCT
ajst-405	49	1	2.4	2.4	NUM
ajst-405	49	2	.	.	PUNCT
ajst-405	50	1	microcystic	microcystic	ADJ
ajst-405	50	2	plugs	plug	NOUN
ajst-405	50	3	compared	compare	VERB
ajst-405	50	4	with	with	ADP
ajst-405	50	5	common	common	ADJ
ajst-405	50	6	plugs	plug	NOUN
ajst-405	50	7	,	,	PUNCT
ajst-405	50	8	microcapsule	microcapsule	ADJ
ajst-405	50	9	plugs	plug	NOUN
ajst-405	50	10	have	have	VERB
ajst-405	50	11	the	the	DET
ajst-405	50	12	advantages	advantage	NOUN
ajst-405	50	13	of	of	ADP
ajst-405	50	14	sustained	sustained	ADJ
ajst-405	50	15	release	release	NOUN
ajst-405	50	16	and	and	CCONJ
ajst-405	50	17	low	low	ADJ
ajst-405	50	18	toxicity	toxicity	NOUN
ajst-405	50	19	,	,	PUNCT
ajst-405	50	20	as	as	ADV
ajst-405	50	21	well	well	ADV
ajst-405	50	22	as	as	ADP
ajst-405	50	23	stable	stable	ADJ
ajst-405	50	24	blood	blood	NOUN
ajst-405	50	25	concentration	concentration	NOUN
ajst-405	50	26	and	and	CCONJ
ajst-405	50	27	long	long	ADJ
ajst-405	50	28	maintenance	maintenance	NOUN
ajst-405	50	29	time	time	NOUN
ajst-405	50	30	.	.	PUNCT
ajst-405	51	1	yihua	yihua	X
ajst-405	51	2	yang	yang	PROPN
ajst-405	51	3	et	et	PROPN
ajst-405	51	4	al	al	PROPN
ajst-405	52	1	[	[	X
ajst-405	52	2	9	9	NUM
ajst-405	52	3	]	]	X
ajst-405	52	4	prepared	prepared	ADJ
ajst-405	52	5	naproxen	naproxen	NOUN
ajst-405	52	6	microcapsule	microcapsule	NOUN
ajst-405	52	7	plugs	plug	NOUN
ajst-405	52	8	and	and	CCONJ
ajst-405	52	9	compared	compare	VERB
ajst-405	52	10	the	the	DET
ajst-405	52	11	cumulative	cumulative	ADJ
ajst-405	52	12	drug	drug	NOUN
ajst-405	52	13	release	release	NOUN
ajst-405	52	14	rate	rate	NOUN
ajst-405	52	15	in	in	ADP
ajst-405	52	16	vitro	vitro	X
ajst-405	52	17	with	with	ADP
ajst-405	52	18	naproxen	naproxen	NOUN
ajst-405	52	19	plain	plain	ADJ
ajst-405	52	20	plugs	plug	NOUN
ajst-405	52	21	.	.	PUNCT
ajst-405	53	1	it	it	PRON
ajst-405	53	2	confirmed	confirm	VERB
ajst-405	53	3	that	that	SCONJ
ajst-405	53	4	the	the	DET
ajst-405	53	5	preparation	preparation	NOUN
ajst-405	53	6	process	process	NOUN
ajst-405	53	7	of	of	ADP
ajst-405	53	8	naproxen	naproxen	NOUN
ajst-405	53	9	microcapsules	microcapsule	NOUN
ajst-405	53	10	was	be	AUX
ajst-405	53	11	simple	simple	ADJ
ajst-405	53	12	and	and	CCONJ
ajst-405	53	13	quality	quality	NOUN
ajst-405	53	14	controlled	control	VERB
ajst-405	53	15	,	,	PUNCT
ajst-405	53	16	and	and	CCONJ
ajst-405	53	17	it	it	PRON
ajst-405	53	18	had	have	VERB
ajst-405	53	19	a	a	DET
ajst-405	53	20	better	well	ADJ
ajst-405	53	21	sustained	sustained	ADJ
ajst-405	53	22	effect	effect	NOUN
ajst-405	53	23	.	.	PUNCT
ajst-405	54	1	lei	lei	PROPN
ajst-405	54	2	wang	wang	PROPN
ajst-405	55	1	[	[	X
ajst-405	55	2	10	10	NUM
ajst-405	55	3	]	]	PUNCT
ajst-405	55	4	et	et	NOUN
ajst-405	55	5	al	al	PROPN
ajst-405	55	6	used	use	VERB
ajst-405	55	7	a	a	DET
ajst-405	55	8	reaggregation	reaggregation	NOUN
ajst-405	55	9	method	method	NOUN
ajst-405	55	10	to	to	PART
ajst-405	55	11	prepare	prepare	VERB
ajst-405	55	12	acetaminophen	acetaminophen	NOUN
ajst-405	55	13	(	(	PUNCT
ajst-405	55	14	aap	aap	PROPN
ajst-405	55	15	)	)	PUNCT
ajst-405	55	16	microcapsules	microcapsule	NOUN
ajst-405	55	17	and	and	CCONJ
ajst-405	55	18	investigated	investigate	VERB
ajst-405	55	19	its	its	PRON
ajst-405	55	20	in	in	X
ajst-405	55	21	vitro	vitro	X
ajst-405	55	22	drug	drug	NOUN
ajst-405	55	23	release	release	NOUN
ajst-405	55	24	behavior	behavior	NOUN
ajst-405	55	25	.	.	PUNCT
ajst-405	56	1	the	the	DET
ajst-405	56	2	prepared	prepare	VERB
ajst-405	56	3	composite	composite	ADJ
ajst-405	56	4	microcapsule	microcapsule	NOUN
ajst-405	56	5	plugs	plug	NOUN
ajst-405	56	6	have	have	VERB
ajst-405	56	7	better	well	ADJ
ajst-405	56	8	drug	drug	NOUN
ajst-405	56	9	release	release	NOUN
ajst-405	56	10	characteristics	characteristic	NOUN
ajst-405	56	11	compared	compare	VERB
ajst-405	56	12	with	with	ADP
ajst-405	56	13	common	common	ADJ
ajst-405	56	14	suppositories	suppository	NOUN
ajst-405	56	15	.	.	PUNCT
ajst-405	57	1	2.5	2.5	NUM
ajst-405	57	2	.	.	PUNCT
ajst-405	58	1	effervescent	effervescent	ADJ
ajst-405	58	2	plugs	plug	NOUN
ajst-405	58	3	in	in	ADP
ajst-405	58	4	comparison	comparison	NOUN
ajst-405	58	5	with	with	ADP
ajst-405	58	6	common	common	ADJ
ajst-405	58	7	suppositories	suppository	NOUN
ajst-405	58	8	,	,	PUNCT
ajst-405	58	9	effervescent	effervescent	ADJ
ajst-405	58	10	suppositories	suppository	NOUN
ajst-405	58	11	are	be	AUX
ajst-405	58	12	particularly	particularly	ADV
ajst-405	58	13	suitable	suitable	ADJ
ajst-405	58	14	for	for	ADP
ajst-405	58	15	gynaecological	gynaecological	ADJ
ajst-405	58	16	diseases	disease	NOUN
ajst-405	58	17	because	because	SCONJ
ajst-405	58	18	they	they	PRON
ajst-405	58	19	can	can	AUX
ajst-405	58	20	produce	produce	VERB
ajst-405	58	21	large	large	ADJ
ajst-405	58	22	quantities	quantity	NOUN
ajst-405	58	23	of	of	ADP
ajst-405	58	24	foam	foam	NOUN
ajst-405	58	25	after	after	ADP
ajst-405	58	26	disintegration	disintegration	NOUN
ajst-405	58	27	,	,	PUNCT
ajst-405	58	28	thus	thus	ADV
ajst-405	58	29	increasing	increase	VERB
ajst-405	58	30	the	the	DET
ajst-405	58	31	contact	contact	NOUN
ajst-405	58	32	area	area	NOUN
ajst-405	58	33	between	between	ADP
ajst-405	58	34	the	the	DET
ajst-405	58	35	drug	drug	NOUN
ajst-405	58	36	and	and	CCONJ
ajst-405	58	37	the	the	DET
ajst-405	58	38	lesion	lesion	NOUN
ajst-405	58	39	site	site	NOUN
ajst-405	58	40	and	and	CCONJ
ajst-405	58	41	better	well	ADV
ajst-405	58	42	exerting	exert	VERB
ajst-405	58	43	their	their	PRON
ajst-405	58	44	efficacy	efficacy	NOUN
ajst-405	58	45	.	.	PUNCT
ajst-405	59	1	jun	jun	PROPN
ajst-405	59	2	yong	yong	PROPN
ajst-405	59	3	jiang	jiang	PROPN
ajst-405	60	1	[	[	X
ajst-405	60	2	11	11	NUM
ajst-405	60	3	]	]	PUNCT
ajst-405	60	4	et	et	PROPN
ajst-405	60	5	al	al	PROPN
ajst-405	60	6	.	.	PROPN
ajst-405	60	7	,	,	PUNCT
ajst-405	60	8	used	use	VERB
ajst-405	60	9	semi	semi	ADV
ajst-405	60	10	synthetic	synthetic	ADJ
ajst-405	60	11	fatty	fatty	NOUN
ajst-405	60	12	acid	acid	NOUN
ajst-405	60	13	glycerides	glyceride	NOUN
ajst-405	60	14	as	as	ADP
ajst-405	60	15	suppository	suppository	ADJ
ajst-405	60	16	matrix	matrix	NOUN
ajst-405	60	17	,	,	PUNCT
ajst-405	60	18	sodium	sodium	NOUN
ajst-405	60	19	bicarbonate	bicarbonate	NOUN
ajst-405	60	20	,	,	PUNCT
ajst-405	60	21	citric	citric	ADJ
ajst-405	60	22	acid	acid	NOUN
ajst-405	60	23	as	as	ADP
ajst-405	60	24	foaming	foaming	NOUN
ajst-405	60	25	agent	agent	NOUN
ajst-405	60	26	,	,	PUNCT
ajst-405	60	27	danazol	danazol	ADJ
ajst-405	60	28	as	as	ADP
ajst-405	60	29	main	main	ADJ
ajst-405	60	30	drug	drug	NOUN
ajst-405	60	31	,	,	PUNCT
ajst-405	60	32	to	to	PART
ajst-405	60	33	prepare	prepare	VERB
ajst-405	60	34	effervetory	effervetory	ADJ
ajst-405	60	35	plugs	plug	NOUN
ajst-405	60	36	,	,	PUNCT
ajst-405	60	37	and	and	CCONJ
ajst-405	60	38	the	the	DET
ajst-405	60	39	produced	produce	VERB
ajst-405	60	40	foam	foam	NOUN
ajst-405	60	41	prolonged	prolong	VERB
ajst-405	60	42	the	the	DET
ajst-405	60	43	drug	drug	NOUN
ajst-405	60	44	action	action	NOUN
ajst-405	60	45	time	time	NOUN
ajst-405	60	46	with	with	ADP
ajst-405	60	47	mucosa	mucosa	NOUN
ajst-405	60	48	as	as	ADV
ajst-405	60	49	well	well	ADV
ajst-405	60	50	as	as	ADP
ajst-405	60	51	contact	contact	NOUN
ajst-405	60	52	area	area	NOUN
ajst-405	60	53	,	,	PUNCT
ajst-405	60	54	increased	increase	VERB
ajst-405	60	55	the	the	DET
ajst-405	60	56	drug	drug	NOUN
ajst-405	60	57	concentration	concentration	NOUN
ajst-405	60	58	in	in	ADP
ajst-405	60	59	local	local	ADJ
ajst-405	60	60	tissue	tissue	NOUN
ajst-405	60	61	,	,	PUNCT
ajst-405	60	62	and	and	CCONJ
ajst-405	60	63	then	then	ADV
ajst-405	60	64	enhanced	enhance	VERB
ajst-405	60	65	the	the	DET
ajst-405	60	66	drug	drug	NOUN
ajst-405	60	67	therapeutic	therapeutic	ADJ
ajst-405	60	68	effect	effect	NOUN
ajst-405	60	69	.	.	PUNCT
ajst-405	61	1	kai	kai	PROPN
ajst-405	61	2	li	li	PROPN
ajst-405	61	3	zhang	zhang	PROPN
ajst-405	61	4	and	and	CCONJ
ajst-405	61	5	others	other	NOUN
ajst-405	61	6	[	[	X
ajst-405	61	7	12	12	NUM
ajst-405	61	8	]	]	PUNCT
ajst-405	61	9	used	use	VERB
ajst-405	61	10	povidone	povidone	NOUN
ajst-405	61	11	iodine	iodine	NOUN
ajst-405	61	12	,	,	PUNCT
ajst-405	61	13	sodium	sodium	NOUN
ajst-405	61	14	bicarbonate	bicarbonate	NOUN
ajst-405	61	15	,	,	PUNCT
ajst-405	61	16	citrate	citrate	NOUN
ajst-405	61	17	and	and	CCONJ
ajst-405	61	18	duckbill	duckbill	NOUN
ajst-405	61	19	shaped	shape	VERB
ajst-405	61	20	suppository	suppository	ADJ
ajst-405	61	21	molding	molding	NOUN
ajst-405	61	22	to	to	PART
ajst-405	61	23	prepare	prepare	VERB
ajst-405	61	24	povidone	povidone	NOUN
ajst-405	61	25	iodophore	iodophore	NOUN
ajst-405	61	26	plug	plug	NOUN
ajst-405	61	27	,	,	PUNCT
ajst-405	61	28	and	and	CCONJ
ajst-405	61	29	it	it	PRON
ajst-405	61	30	was	be	AUX
ajst-405	61	31	found	find	VERB
ajst-405	61	32	that	that	SCONJ
ajst-405	61	33	the	the	DET
ajst-405	61	34	preparation	preparation	NOUN
ajst-405	61	35	process	process	NOUN
ajst-405	61	36	of	of	ADP
ajst-405	61	37	povidone	povidone	NOUN
ajst-405	61	38	iodophore	iodophore	ADJ
ajst-405	61	39	plug	plug	NOUN
ajst-405	61	40	was	be	AUX
ajst-405	61	41	simple	simple	ADJ
ajst-405	61	42	,	,	PUNCT
ajst-405	61	43	stable	stable	ADJ
ajst-405	61	44	and	and	CCONJ
ajst-405	61	45	convenient	convenient	ADJ
ajst-405	61	46	for	for	ADP
ajst-405	61	47	quality	quality	NOUN
ajst-405	61	48	control	control	NOUN
ajst-405	61	49	,	,	PUNCT
ajst-405	61	50	which	which	PRON
ajst-405	61	51	did	do	AUX
ajst-405	61	52	not	not	PART
ajst-405	61	53	affect	affect	VERB
ajst-405	61	54	the	the	DET
ajst-405	61	55	iodine	iodine	NOUN
ajst-405	61	56	content	content	NOUN
ajst-405	61	57	when	when	SCONJ
ajst-405	61	58	stored	store	VERB
ajst-405	61	59	at	at	ADP
ajst-405	61	60	low	low	ADJ
ajst-405	61	61	temperature	temperature	NOUN
ajst-405	61	62	and	and	CCONJ
ajst-405	61	63	had	have	VERB
ajst-405	61	64	a	a	DET
ajst-405	61	65	long	long	ADJ
ajst-405	61	66	validity	validity	NOUN
ajst-405	61	67	period	period	NOUN
ajst-405	61	68	of	of	ADP
ajst-405	61	69	432d	432d	NUM
ajst-405	61	70	.	.	PUNCT
ajst-405	62	1	2.6	2.6	NUM
ajst-405	62	2	.	.	PUNCT
ajst-405	63	1	sponge	sponge	NOUN
ajst-405	63	2	plugs	plug	NOUN
ajst-405	63	3	compared	compare	VERB
ajst-405	63	4	with	with	ADP
ajst-405	63	5	common	common	ADJ
ajst-405	63	6	suppositories	suppository	NOUN
ajst-405	63	7	,	,	PUNCT
ajst-405	63	8	sponge	sponge	NOUN
ajst-405	63	9	suppositories	suppository	NOUN
ajst-405	63	10	can	can	AUX
ajst-405	63	11	be	be	AUX
ajst-405	63	12	persistently	persistently	ADV
ajst-405	63	13	dispersed	disperse	VERB
ajst-405	63	14	on	on	ADP
ajst-405	63	15	the	the	DET
ajst-405	63	16	mucosal	mucosal	NOUN
ajst-405	63	17	surface	surface	NOUN
ajst-405	63	18	of	of	ADP
ajst-405	63	19	the	the	DET
ajst-405	63	20	luminal	luminal	ADJ
ajst-405	63	21	tract	tract	NOUN
ajst-405	63	22	,	,	PUNCT
ajst-405	63	23	avoid	avoid	VERB
ajst-405	63	24	the	the	DET
ajst-405	63	25	deficiency	deficiency	NOUN
ajst-405	63	26	of	of	ADP
ajst-405	63	27	loss	loss	NOUN
ajst-405	63	28	due	due	ADP
ajst-405	63	29	to	to	ADP
ajst-405	63	30	matrix	matrix	NOUN
ajst-405	63	31	melting	melting	NOUN
ajst-405	63	32	,	,	PUNCT
ajst-405	63	33	and	and	CCONJ
ajst-405	63	34	maintain	maintain	VERB
ajst-405	63	35	their	their	PRON
ajst-405	63	36	efficacy	efficacy	NOUN
ajst-405	63	37	for	for	ADP
ajst-405	63	38	a	a	DET
ajst-405	63	39	long	long	ADJ
ajst-405	63	40	time	time	NOUN
ajst-405	63	41	,	,	PUNCT
ajst-405	63	42	which	which	PRON
ajst-405	63	43	is	be	AUX
ajst-405	63	44	generally	generally	ADV
ajst-405	63	45	vaginal	vaginal	ADJ
ajst-405	63	46	.	.	PUNCT
ajst-405	64	1	the	the	DET
ajst-405	64	2	common	common	ADJ
ajst-405	64	3	matrix	matrix	NOUN
ajst-405	64	4	is	be	AUX
ajst-405	64	5	gelatin	gelatin	NOUN
ajst-405	64	6	,	,	PUNCT
ajst-405	64	7	and	and	CCONJ
ajst-405	64	8	the	the	DET
ajst-405	64	9	produced	produce	VERB
ajst-405	64	10	suppositories	suppository	NOUN
ajst-405	64	11	can	can	AUX
ajst-405	64	12	be	be	AUX
ajst-405	64	13	enzymatically	enzymatically	ADV
ajst-405	64	14	absorbed	absorb	VERB
ajst-405	64	15	in	in	ADP
ajst-405	64	16	vivo	vivo	NOUN
ajst-405	64	17	for	for	ADP
ajst-405	64	18	convenient	convenient	ADJ
ajst-405	64	19	use	use	NOUN
ajst-405	64	20	.	.	PUNCT
ajst-405	65	1	a	a	DET
ajst-405	65	2	sponge	sponge	NOUN
ajst-405	65	3	vaginal	vaginal	ADJ
ajst-405	65	4	plug	plug	NOUN
ajst-405	65	5	of	of	ADP
ajst-405	65	6	tinidazole	tinidazole	NOUN
ajst-405	65	7	developed	develop	VERB
ajst-405	65	8	by	by	ADP
ajst-405	65	9	meng	meng	PROPN
ajst-405	65	10	shengmen	shengmen	PROPN
ajst-405	65	11	et	et	PROPN
ajst-405	65	12	al	al	PROPN
ajst-405	65	13	.	.	PUNCT
ajst-405	66	1	[	[	X
ajst-405	66	2	13	13	NUM
ajst-405	66	3	]	]	PUNCT
ajst-405	66	4	and	and	CCONJ
ajst-405	66	5	in	in	ADP
ajst-405	66	6	vitro	vitro	X
ajst-405	66	7	tests	test	NOUN
ajst-405	66	8	proved	prove	VERB
ajst-405	66	9	that	that	SCONJ
ajst-405	66	10	it	it	PRON
ajst-405	66	11	had	have	VERB
ajst-405	66	12	a	a	DET
ajst-405	66	13	slow	slow	ADJ
ajst-405	66	14	-	-	PUNCT
ajst-405	66	15	release	release	NOUN
ajst-405	66	16	effect	effect	NOUN
ajst-405	66	17	;	;	PUNCT
ajst-405	66	18	clinical	clinical	ADJ
ajst-405	66	19	observations	observation	NOUN
ajst-405	66	20	have	have	AUX
ajst-405	66	21	shown	show	VERB
ajst-405	66	22	that	that	SCONJ
ajst-405	66	23	this	this	DET
ajst-405	66	24	formulation	formulation	NOUN
ajst-405	66	25	has	have	VERB
ajst-405	66	26	high	high	ADJ
ajst-405	66	27	efficacy	efficacy	NOUN
ajst-405	66	28	,	,	PUNCT
ajst-405	66	29	short	short	ADJ
ajst-405	66	30	treatment	treatment	NOUN
ajst-405	66	31	duration	duration	NOUN
ajst-405	66	32	and	and	CCONJ
ajst-405	66	33	little	little	ADJ
ajst-405	66	34	side	side	NOUN
ajst-405	66	35	effects	effect	NOUN
ajst-405	66	36	,	,	PUNCT
ajst-405	66	37	and	and	CCONJ
ajst-405	66	38	it	it	PRON
ajst-405	66	39	is	be	AUX
ajst-405	66	40	of	of	ADP
ajst-405	66	41	value	value	NOUN
ajst-405	66	42	for	for	ADP
ajst-405	66	43	widespread	widespread	ADJ
ajst-405	66	44	use	use	NOUN
ajst-405	66	45	.	.	PUNCT
ajst-405	67	1	xu	xu	PROPN
ajst-405	68	1	ziyou	ziyou	PROPN
ajst-405	68	2	et	et	PROPN
ajst-405	68	3	al	al	PROPN
ajst-405	69	1	[	[	X
ajst-405	69	2	14	14	NUM
ajst-405	69	3	]	]	PUNCT
ajst-405	69	4	demonstrated	demonstrate	VERB
ajst-405	69	5	that	that	SCONJ
ajst-405	69	6	compared	compare	VERB
ajst-405	69	7	with	with	ADP
ajst-405	69	8	metronidazole	metronidazole	NOUN
ajst-405	69	9	suppositories	suppository	NOUN
ajst-405	69	10	based	base	VERB
ajst-405	69	11	on	on	ADP
ajst-405	69	12	polyethylene	polyethylene	NOUN
ajst-405	69	13	glycol	glycol	NOUN
ajst-405	69	14	,	,	PUNCT
ajst-405	69	15	metronidazole	metronidazole	NOUN
ajst-405	69	16	vaginal	vaginal	ADJ
ajst-405	69	17	sponge	sponge	NOUN
ajst-405	69	18	suppositories	suppository	NOUN
ajst-405	69	19	based	base	VERB
ajst-405	69	20	on	on	ADP
ajst-405	69	21	polyether	polyether	ADJ
ajst-405	69	22	type	type	NOUN
ajst-405	69	23	polyurethane	polyurethane	NOUN
ajst-405	69	24	foam	foam	NOUN
ajst-405	69	25	were	be	AUX
ajst-405	69	26	long	long	ADV
ajst-405	69	27	-	-	PUNCT
ajst-405	69	28	lasting	last	VERB
ajst-405	69	29	,	,	PUNCT
ajst-405	69	30	safe	safe	ADJ
ajst-405	69	31	,	,	PUNCT
ajst-405	69	32	and	and	CCONJ
ajst-405	69	33	convenient	convenient	ADJ
ajst-405	69	34	to	to	PART
ajst-405	69	35	use	use	VERB
ajst-405	69	36	.	.	PUNCT
ajst-405	70	1	2.7	2.7	NUM
ajst-405	70	2	.	.	PUNCT
ajst-405	71	1	no	no	DET
ajst-405	71	2	thrombolytic	thrombolytic	ADJ
ajst-405	71	3	agent	agent	NOUN
ajst-405	71	4	thrombolysis	thrombolysis	NOUN
ajst-405	71	5	insoluble	insoluble	ADJ
ajst-405	71	6	suppositories	suppository	NOUN
ajst-405	71	7	,	,	PUNCT
ajst-405	71	8	which	which	PRON
ajst-405	71	9	are	be	AUX
ajst-405	71	10	neither	neither	CCONJ
ajst-405	71	11	dissolved	dissolve	VERB
ajst-405	71	12	nor	nor	CCONJ
ajst-405	71	13	disintegrated	disintegrate	VERB
ajst-405	71	14	in	in	ADP
ajst-405	71	15	the	the	DET
ajst-405	71	16	rectum	rectum	NOUN
ajst-405	71	17	,	,	PUNCT
ajst-405	71	18	exert	exert	VERB
ajst-405	71	19	their	their	PRON
ajst-405	71	20	efficacy	efficacy	NOUN
ajst-405	71	21	by	by	ADP
ajst-405	71	22	absorbing	absorb	VERB
ajst-405	71	23	moisture	moisture	NOUN
ajst-405	71	24	that	that	PRON
ajst-405	71	25	gradually	gradually	ADV
ajst-405	71	26	swells	swell	VERB
ajst-405	71	27	,	,	PUNCT
ajst-405	71	28	slowly	slowly	ADV
ajst-405	71	29	releasing	release	VERB
ajst-405	71	30	the	the	DET
ajst-405	71	31	drug	drug	NOUN
ajst-405	71	32	.	.	PUNCT
ajst-405	72	1	a	a	DET
ajst-405	72	2	long	long	ADV
ajst-405	72	3	-	-	PUNCT
ajst-405	72	4	acting	act	VERB
ajst-405	72	5	lidocaine	lidocaine	NOUN
ajst-405	72	6	plug	plug	NOUN
ajst-405	72	7	developed	develop	VERB
ajst-405	72	8	by	by	ADP
ajst-405	72	9	the	the	DET
ajst-405	72	10	inveresk	inveresk	PROPN
ajst-405	72	11	institute	institute	PROPN
ajst-405	72	12	in	in	ADP
ajst-405	72	13	the	the	DET
ajst-405	72	14	united	united	PROPN
ajst-405	72	15	kingdom	kingdom	PROPN
ajst-405	72	16	,	,	PUNCT
ajst-405	72	17	using	use	VERB
ajst-405	72	18	hydroxypropyl	hydroxypropyl	NOUN
ajst-405	72	19	methylcellulose	methylcellulose	NOUN
ajst-405	72	20	of	of	ADP
ajst-405	72	21	relative	relative	ADJ
ajst-405	72	22	molecular	molecular	ADJ
ajst-405	72	23	mass	mass	NOUN
ajst-405	72	24	200000	200000	NUM
ajst-405	72	25	as	as	ADP
ajst-405	72	26	matrix	matrix	NOUN
ajst-405	72	27	and	and	CCONJ
ajst-405	72	28	25	25	NUM
ajst-405	72	29	%	%	NOUN
ajst-405	72	30	drug	drug	NOUN
ajst-405	72	31	release	release	NOUN
ajst-405	72	32	in	in	ADP
ajst-405	72	33	1	1	NUM
ajst-405	72	34	h	h	NOUN
ajst-405	72	35	and	and	CCONJ
ajst-405	72	36	65	65	NUM
ajst-405	72	37	%	%	NOUN
ajst-405	72	38	drug	drug	NOUN
ajst-405	72	39	release	release	NOUN
ajst-405	72	40	in	in	ADP
ajst-405	72	41	4	4	NUM
ajst-405	72	42	h	h	NOUN
ajst-405	72	43	,	,	PUNCT
ajst-405	72	44	could	could	AUX
ajst-405	72	45	maintain	maintain	VERB
ajst-405	72	46	effective	effective	ADJ
ajst-405	72	47	blood	blood	NOUN
ajst-405	72	48	concentration	concentration	NOUN
ajst-405	72	49	for	for	ADP
ajst-405	72	50	up	up	ADP
ajst-405	72	51	to	to	PART
ajst-405	72	52	24	24	NUM
ajst-405	72	53	h	h	NOUN
ajst-405	73	1	[	[	X
ajst-405	73	2	15	15	NUM
ajst-405	73	3	]	]	PUNCT
ajst-405	73	4	.	.	PUNCT
ajst-405	74	1	2.8	2.8	NUM
ajst-405	74	2	.	.	PUNCT
ajst-405	74	3	gel	gel	NOUN
ajst-405	74	4	suppository	suppository	NOUN
ajst-405	74	5	plugs	plug	NOUN
ajst-405	74	6	compared	compare	VERB
ajst-405	74	7	with	with	ADP
ajst-405	74	8	common	common	ADJ
ajst-405	74	9	suppositories	suppository	NOUN
ajst-405	74	10	,	,	PUNCT
ajst-405	74	11	the	the	DET
ajst-405	74	12	foreign	foreign	ADJ
ajst-405	74	13	body	body	NOUN
ajst-405	74	14	42	42	NUM
ajst-405	74	15	sensation	sensation	NOUN
ajst-405	74	16	generated	generate	VERB
ajst-405	74	17	after	after	SCONJ
ajst-405	74	18	the	the	DET
ajst-405	74	19	incorporation	incorporation	NOUN
ajst-405	74	20	of	of	ADP
ajst-405	74	21	suppositories	suppository	NOUN
ajst-405	74	22	into	into	ADP
ajst-405	74	23	the	the	DET
ajst-405	74	24	body	body	NOUN
ajst-405	74	25	cavity	cavity	NOUN
ajst-405	74	26	can	can	AUX
ajst-405	74	27	be	be	AUX
ajst-405	74	28	avoided	avoid	VERB
ajst-405	74	29	due	due	ADP
ajst-405	74	30	to	to	ADP
ajst-405	74	31	the	the	DET
ajst-405	74	32	fact	fact	NOUN
ajst-405	74	33	that	that	SCONJ
ajst-405	74	34	the	the	DET
ajst-405	74	35	gels	gel	NOUN
ajst-405	74	36	have	have	AUX
ajst-405	74	37	a	a	DET
ajst-405	74	38	special	special	ADJ
ajst-405	74	39	adhesive	adhesive	ADJ
ajst-405	74	40	force	force	NOUN
ajst-405	74	41	to	to	ADP
ajst-405	74	42	the	the	DET
ajst-405	74	43	biological	biological	ADJ
ajst-405	74	44	mucosa	mucosa	NOUN
ajst-405	74	45	,	,	PUNCT
ajst-405	74	46	which	which	PRON
ajst-405	74	47	can	can	AUX
ajst-405	74	48	prolong	prolong	VERB
ajst-405	74	49	the	the	DET
ajst-405	74	50	retention	retention	NOUN
ajst-405	74	51	and	and	CCONJ
ajst-405	74	52	release	release	VERB
ajst-405	74	53	time	time	NOUN
ajst-405	74	54	of	of	ADP
ajst-405	74	55	drugs	drug	NOUN
ajst-405	74	56	to	to	PART
ajst-405	74	57	promote	promote	VERB
ajst-405	74	58	the	the	DET
ajst-405	74	59	absorption	absorption	NOUN
ajst-405	74	60	of	of	ADP
ajst-405	74	61	drugs	drug	NOUN
ajst-405	74	62	and	and	CCONJ
ajst-405	74	63	improve	improve	VERB
ajst-405	74	64	the	the	DET
ajst-405	74	65	bioavailability	bioavailability	NOUN
ajst-405	74	66	of	of	ADP
ajst-405	74	67	drugs	drug	NOUN
ajst-405	74	68	.	.	PUNCT
ajst-405	75	1	huoshinmei	huoshinmei	PROPN
ajst-405	76	1	[	[	X
ajst-405	76	2	16	16	NUM
ajst-405	76	3	]	]	PUNCT
ajst-405	76	4	used	use	VERB
ajst-405	76	5	white	white	ADJ
ajst-405	76	6	clear	clear	ADJ
ajst-405	76	7	gelatinous	gelatinous	ADJ
ajst-405	76	8	semi	semi	ADJ
ajst-405	76	9	-	-	ADJ
ajst-405	76	10	solid	solid	ADJ
ajst-405	76	11	water	water	NOUN
ajst-405	76	12	-	-	PUNCT
ajst-405	76	13	soluble	soluble	ADJ
ajst-405	76	14	gel	gel	NOUN
ajst-405	76	15	composite	composite	ADJ
ajst-405	76	16	tinidazole	tinidazole	NOUN
ajst-405	76	17	hydrogel	hydrogel	NOUN
ajst-405	76	18	plugs	plug	NOUN
ajst-405	76	19	fabricated	fabricate	VERB
ajst-405	76	20	from	from	ADP
ajst-405	76	21	tinidazole	tinidazole	NOUN
ajst-405	76	22	,	,	PUNCT
ajst-405	76	23	chlorhexidine	chlorhexidine	NOUN
ajst-405	76	24	acetate	acetate	NOUN
ajst-405	76	25	,	,	PUNCT
ajst-405	76	26	clotrimazole	clotrimazole	NOUN
ajst-405	76	27	with	with	ADP
ajst-405	76	28	matrix	matrix	NOUN
ajst-405	76	29	poloxamer	poloxamer	NOUN
ajst-405	76	30	p407	p407	PROPN
ajst-405	76	31	,	,	PUNCT
ajst-405	76	32	carbomer	carbomer	NOUN
ajst-405	76	33	and	and	CCONJ
ajst-405	76	34	other	other	ADJ
ajst-405	76	35	excipients	excipient	NOUN
ajst-405	76	36	processed	process	VERB
ajst-405	76	37	by	by	ADP
ajst-405	76	38	advanced	advanced	ADJ
ajst-405	76	39	processes	process	NOUN
ajst-405	76	40	to	to	PART
ajst-405	76	41	improve	improve	VERB
ajst-405	76	42	the	the	DET
ajst-405	76	43	traditional	traditional	ADJ
ajst-405	76	44	suppositories	suppository	NOUN
ajst-405	76	45	'	'	PART
ajst-405	76	46	inability	inability	NOUN
ajst-405	76	47	of	of	ADP
ajst-405	76	48	sustained	sustained	ADJ
ajst-405	76	49	and	and	CCONJ
ajst-405	76	50	constant	constant	ADJ
ajst-405	76	51	drug	drug	NOUN
ajst-405	76	52	release	release	NOUN
ajst-405	76	53	and	and	CCONJ
ajst-405	76	54	susceptibility	susceptibility	NOUN
ajst-405	76	55	to	to	ADP
ajst-405	76	56	body	body	NOUN
ajst-405	76	57	temperature	temperature	NOUN
ajst-405	76	58	,	,	PUNCT
ajst-405	76	59	which	which	PRON
ajst-405	76	60	resulted	result	VERB
ajst-405	76	61	in	in	ADP
ajst-405	76	62	liquid	liquid	NOUN
ajst-405	76	63	like	like	ADP
ajst-405	76	64	efflux	efflux	NOUN
ajst-405	76	65	of	of	ADP
ajst-405	76	66	matrix	matrix	NOUN
ajst-405	76	67	after	after	ADP
ajst-405	76	68	thawing	thaw	VERB
ajst-405	76	69	and	and	CCONJ
ajst-405	76	70	contaminated	contaminate	VERB
ajst-405	76	71	clothing	clothing	NOUN
ajst-405	76	72	.	.	PUNCT
ajst-405	77	1	the	the	DET
ajst-405	77	2	compound	compound	NOUN
ajst-405	77	3	tinidazole	tinidazole	PROPN
ajst-405	77	4	hydrogel	hydrogel	NOUN
ajst-405	77	5	plug	plug	NOUN
ajst-405	77	6	has	have	VERB
ajst-405	77	7	a	a	DET
ajst-405	77	8	high	high	ADJ
ajst-405	77	9	local	local	ADJ
ajst-405	77	10	concentration	concentration	NOUN
ajst-405	77	11	in	in	ADP
ajst-405	77	12	the	the	DET
ajst-405	77	13	vagina	vagina	NOUN
ajst-405	77	14	after	after	ADP
ajst-405	77	15	use	use	NOUN
ajst-405	77	16	,	,	PUNCT
ajst-405	77	17	no	no	DET
ajst-405	77	18	adverse	adverse	ADJ
ajst-405	77	19	effects	effect	NOUN
ajst-405	77	20	have	have	AUX
ajst-405	77	21	been	be	AUX
ajst-405	77	22	reported	report	VERB
ajst-405	77	23	at	at	ADP
ajst-405	77	24	this	this	DET
ajst-405	77	25	time	time	NOUN
ajst-405	77	26	,	,	PUNCT
ajst-405	77	27	and	and	CCONJ
ajst-405	77	28	it	it	PRON
ajst-405	77	29	can	can	AUX
ajst-405	77	30	be	be	AUX
ajst-405	77	31	released	release	VERB
ajst-405	77	32	continuously	continuously	ADV
ajst-405	77	33	in	in	ADP
ajst-405	77	34	a	a	DET
ajst-405	77	35	stable	stable	ADJ
ajst-405	77	36	manner	manner	NOUN
ajst-405	77	37	to	to	PART
ajst-405	77	38	achieve	achieve	VERB
ajst-405	77	39	sustained	sustained	ADJ
ajst-405	77	40	release	release	NOUN
ajst-405	77	41	.	.	PUNCT
ajst-405	78	1	2.9	2.9	NUM
ajst-405	78	2	.	.	PUNCT
ajst-405	78	3	sustained	sustain	VERB
ajst-405	78	4	release	release	NOUN
ajst-405	78	5	thrombus	thrombus	NOUN
ajst-405	78	6	sustained	sustain	VERB
ajst-405	78	7	release	release	NOUN
ajst-405	78	8	suppositories	suppository	NOUN
ajst-405	78	9	,	,	PUNCT
ajst-405	78	10	suppositories	suppository	NOUN
ajst-405	78	11	made	make	VERB
ajst-405	78	12	by	by	ADP
ajst-405	78	13	encapsulating	encapsulate	VERB
ajst-405	78	14	drugs	drug	NOUN
ajst-405	78	15	into	into	ADP
ajst-405	78	16	a	a	DET
ajst-405	78	17	plastic	plastic	ADJ
ajst-405	78	18	insoluble	insoluble	ADJ
ajst-405	78	19	polymeric	polymeric	ADJ
ajst-405	78	20	material	material	NOUN
ajst-405	78	21	,	,	PUNCT
ajst-405	78	22	do	do	AUX
ajst-405	78	23	not	not	PART
ajst-405	78	24	dissolve	dissolve	VERB
ajst-405	78	25	at	at	ADP
ajst-405	78	26	the	the	DET
ajst-405	78	27	site	site	NOUN
ajst-405	78	28	of	of	ADP
ajst-405	78	29	administration	administration	NOUN
ajst-405	78	30	,	,	PUNCT
ajst-405	78	31	the	the	DET
ajst-405	78	32	drug	drug	NOUN
ajst-405	78	33	must	must	AUX
ajst-405	78	34	first	first	ADV
ajst-405	78	35	diffuse	diffuse	VERB
ajst-405	78	36	out	out	ADP
ajst-405	78	37	of	of	ADP
ajst-405	78	38	the	the	DET
ajst-405	78	39	insoluble	insoluble	ADJ
ajst-405	78	40	matrix	matrix	NOUN
ajst-405	78	41	and	and	CCONJ
ajst-405	78	42	slowly	slowly	ADV
ajst-405	78	43	release	release	VERB
ajst-405	78	44	the	the	DET
ajst-405	78	45	drug	drug	NOUN
ajst-405	78	46	through	through	ADP
ajst-405	78	47	the	the	DET
ajst-405	78	48	dissolving	dissolve	VERB
ajst-405	78	49	effect	effect	NOUN
ajst-405	78	50	of	of	ADP
ajst-405	78	51	mucosal	mucosal	ADJ
ajst-405	78	52	fluid	fluid	NOUN
ajst-405	78	53	,	,	PUNCT
ajst-405	78	54	so	so	SCONJ
ajst-405	78	55	as	as	SCONJ
ajst-405	78	56	to	to	PART
ajst-405	78	57	play	play	VERB
ajst-405	78	58	a	a	DET
ajst-405	78	59	retarding	retard	VERB
ajst-405	78	60	role	role	NOUN
ajst-405	78	61	in	in	ADP
ajst-405	78	62	the	the	DET
ajst-405	78	63	dissolution	dissolution	NOUN
ajst-405	78	64	and	and	CCONJ
ajst-405	78	65	release	release	NOUN
ajst-405	78	66	of	of	ADP
ajst-405	78	67	the	the	DET
ajst-405	78	68	drug	drug	NOUN
ajst-405	78	69	[	[	X
ajst-405	78	70	17	17	NUM
ajst-405	78	71	]	]	PUNCT
ajst-405	78	72	.	.	PUNCT
ajst-405	79	1	in	in	ADP
ajst-405	79	2	the	the	DET
ajst-405	79	3	development	development	NOUN
ajst-405	79	4	of	of	ADP
ajst-405	79	5	indomethacin	indomethacin	PROPN
ajst-405	79	6	sustainedrelease	sustainedrelease	PROPN
ajst-405	79	7	suppository	suppository	PROPN
ajst-405	79	8	and	and	CCONJ
ajst-405	79	9	determination	determination	NOUN
ajst-405	79	10	of	of	ADP
ajst-405	79	11	its	its	PRON
ajst-405	79	12	bioavailability	bioavailability	NOUN
ajst-405	79	13	,	,	PUNCT
ajst-405	79	14	it	it	PRON
ajst-405	79	15	was	be	AUX
ajst-405	79	16	found	find	VERB
ajst-405	79	17	that	that	SCONJ
ajst-405	79	18	this	this	DET
ajst-405	79	19	formulation	formulation	NOUN
ajst-405	79	20	exhibited	exhibit	VERB
ajst-405	79	21	reduced	reduce	VERB
ajst-405	79	22	peak	peak	NOUN
ajst-405	79	23	concentration	concentration	NOUN
ajst-405	79	24	,	,	PUNCT
ajst-405	79	25	prolonged	prolong	VERB
ajst-405	79	26	time	time	NOUN
ajst-405	79	27	to	to	PART
ajst-405	79	28	peak	peak	VERB
ajst-405	79	29	,	,	PUNCT
ajst-405	79	30	and	and	CCONJ
ajst-405	79	31	distinct	distinct	ADJ
ajst-405	79	32	sustainedrelease	sustainedrelease	PROPN
ajst-405	79	33	profile	profile	NOUN
ajst-405	79	34	compared	compare	VERB
ajst-405	79	35	with	with	ADP
ajst-405	79	36	common	common	ADJ
ajst-405	79	37	suppositories	suppository	NOUN
ajst-405	79	38	[	[	X
ajst-405	79	39	18	18	NUM
ajst-405	79	40	]	]	PUNCT
ajst-405	79	41	.	.	PUNCT
ajst-405	80	1	he	he	PRON
ajst-405	80	2	xin	xin	PROPN
ajst-405	80	3	et	et	PROPN
ajst-405	80	4	al	al	PROPN
ajst-405	80	5	.	.	PUNCT
ajst-405	81	1	[	[	X
ajst-405	81	2	19	19	NUM
ajst-405	81	3	]	]	PUNCT
ajst-405	81	4	used	use	VERB
ajst-405	81	5	metronidazole	metronidazole	NOUN
ajst-405	81	6	and	and	CCONJ
ajst-405	81	7	miconazole	miconazole	NOUN
ajst-405	81	8	nitrate	nitrate	NOUN
ajst-405	81	9	as	as	ADP
ajst-405	81	10	the	the	DET
ajst-405	81	11	main	main	ADJ
ajst-405	81	12	drugs	drug	NOUN
ajst-405	81	13	,	,	PUNCT
ajst-405	81	14	hydroxypropyl	hydroxypropyl	VERB
ajst-405	81	15	methylcellulose	methylcellulose	NOUN
ajst-405	81	16	as	as	ADP
ajst-405	81	17	the	the	DET
ajst-405	81	18	backbone	backbone	NOUN
ajst-405	81	19	material	material	NOUN
ajst-405	81	20	,	,	PUNCT
ajst-405	81	21	and	and	CCONJ
ajst-405	81	22	used	use	VERB
ajst-405	81	23	hot	hot	ADJ
ajst-405	81	24	-	-	PUNCT
ajst-405	81	25	melt	melt	NOUN
ajst-405	81	26	method	method	NOUN
ajst-405	81	27	to	to	PART
ajst-405	81	28	prepare	prepare	VERB
ajst-405	81	29	sustained	sustain	VERB
ajst-405	81	30	-	-	PUNCT
ajst-405	81	31	release	release	NOUN
ajst-405	81	32	suppositories	suppository	NOUN
ajst-405	81	33	,	,	PUNCT
ajst-405	81	34	which	which	PRON
ajst-405	81	35	compared	compare	VERB
ajst-405	81	36	with	with	ADP
ajst-405	81	37	common	common	ADJ
ajst-405	81	38	suppositories	suppository	NOUN
ajst-405	81	39	can	can	AUX
ajst-405	81	40	not	not	PART
ajst-405	81	41	only	only	ADV
ajst-405	81	42	prolong	prolong	VERB
ajst-405	81	43	the	the	DET
ajst-405	81	44	drug	drug	NOUN
ajst-405	81	45	efficacy	efficacy	NOUN
ajst-405	81	46	and	and	CCONJ
ajst-405	81	47	reduce	reduce	VERB
ajst-405	81	48	the	the	DET
ajst-405	81	49	administration	administration	NOUN
ajst-405	81	50	frequency	frequency	NOUN
ajst-405	81	51	,	,	PUNCT
ajst-405	81	52	but	but	CCONJ
ajst-405	81	53	also	also	ADV
ajst-405	81	54	flatten	flatten	VERB
ajst-405	81	55	the	the	DET
ajst-405	81	56	release	release	NOUN
ajst-405	81	57	of	of	ADP
ajst-405	81	58	drugs	drug	NOUN
ajst-405	81	59	,	,	PUNCT
ajst-405	81	60	and	and	CCONJ
ajst-405	81	61	can	can	AUX
ajst-405	81	62	maintain	maintain	VERB
ajst-405	81	63	effective	effective	ADJ
ajst-405	81	64	drug	drug	NOUN
ajst-405	81	65	concentrations	concentration	NOUN
ajst-405	81	66	to	to	PART
ajst-405	81	67	maintain	maintain	VERB
ajst-405	81	68	treatment	treatment	NOUN
ajst-405	81	69	.	.	PUNCT
ajst-405	82	1	references	reference	NOUN
ajst-405	82	2	[	[	X
ajst-405	82	3	1	1	NUM
ajst-405	82	4	]	]	PUNCT
ajst-405	82	5	minzh	minzh	PROPN
ajst-405	82	6	sun	sun	PROPN
ajst-405	82	7	,	,	PUNCT
ajst-405	82	8	jianzhi	jianzhi	PROPN
ajst-405	82	9	zhao	zhao	PROPN
ajst-405	82	10	,	,	PUNCT
ajst-405	82	11	xiuqin	xiuqin	PROPN
ajst-405	82	12	li	li	PROPN
ajst-405	82	13	,	,	PUNCT
ajst-405	82	14	guike	guike	PROPN
ajst-405	82	15	li	li	PROPN
ajst-405	82	16	,	,	PUNCT
ajst-405	82	17	xiumei	xiumei	PROPN
ajst-405	82	18	wu	wu	PROPN
ajst-405	82	19	,	,	PUNCT
ajst-405	82	20	chenggui	chenggui	PROPN
ajst-405	82	21	zhang	zhang	PROPN
ajst-405	82	22	,	,	PUNCT
ajst-405	82	23	pengfei	pengfei	PROPN
ajst-405	82	24	gao	gao	PROPN
ajst-405	82	25	and	and	CCONJ
ajst-405	82	26	miao	miao	NOUN
ajst-405	82	27	he	he	PRON
ajst-405	82	28	development	development	NOUN
ajst-405	82	29	and	and	CCONJ
ajst-405	82	30	application	application	NOUN
ajst-405	82	31	of	of	ADP
ajst-405	82	32	suppositories	suppository	NOUN
ajst-405	82	33	[	[	X
ajst-405	82	34	j	j	X
ajst-405	82	35	]	]	X
ajst-405	82	36	guangzhou	guangzhou	PROPN
ajst-405	82	37	chemicals	chemical	NOUN
ajst-405	82	38	,	,	PUNCT
ajst-405	82	39	2016	2016	NUM
ajst-405	82	40	,	,	PUNCT
ajst-405	82	41	44	44	NUM
ajst-405	82	42	(	(	PUNCT
ajst-405	82	43	13	13	NUM
ajst-405	82	44	):	):	PUNCT
ajst-405	82	45	1	1	NUM
ajst-405	82	46	-	-	SYM
ajst-405	82	47	3	3	NUM
ajst-405	82	48	+	+	NUM
ajst-405	82	49	28	28	NUM
ajst-405	82	50	.	.	PUNCT
ajst-405	83	1	[	[	X
ajst-405	83	2	2	2	X
ajst-405	83	3	]	]	X
ajst-405	83	4	yang	yang	PROPN
ajst-405	83	5	na	na	PROPN
ajst-405	83	6	,	,	PUNCT
ajst-405	83	7	wu	wu	PROPN
ajst-405	83	8	kong	kong	PROPN
ajst-405	83	9	yun	yun	PROPN
ajst-405	83	10	,	,	PUNCT
ajst-405	83	11	liang	liang	PROPN
ajst-405	83	12	guang	guang	PROPN
ajst-405	83	13	yi	yi	PROPN
ajst-405	83	14	,	,	PUNCT
ajst-405	83	15	jin	jin	PROPN
ajst-405	83	16	feng	feng	PROPN
ajst-405	83	17	yun	yun	PROPN
ajst-405	83	18	,	,	PUNCT
ajst-405	83	19	huang	huang	PROPN
ajst-405	83	20	y	y	PROPN
ajst-405	83	21	qi	qi	PROPN
ajst-405	83	22	,	,	PUNCT
ajst-405	83	23	chen	chen	PROPN
ajst-405	83	24	jw	jw	PROPN
ajst-405	83	25	development	development	PROPN
ajst-405	83	26	of	of	ADP
ajst-405	83	27	suppositories	suppository	NOUN
ajst-405	83	28	[	[	X
ajst-405	83	29	j	j	X
ajst-405	83	30	]	]	X
ajst-405	83	31	school	school	NOUN
ajst-405	83	32	journal	journal	NOUN
ajst-405	83	33	(	(	PUNCT
ajst-405	83	34	natural	natural	ADJ
ajst-405	83	35	science	science	NOUN
ajst-405	83	36	edition	edition	NOUN
ajst-405	83	37	)	)	PUNCT
ajst-405	83	38	,	,	PUNCT
ajst-405	83	39	2007	2007	NUM
ajst-405	83	40	,	,	PUNCT
ajst-405	83	41	(	(	PUNCT
ajst-405	83	42	04	04	NUM
ajst-405	83	43	):	):	PUNCT
ajst-405	83	44	45	45	NUM
ajst-405	83	45	-	-	SYM
ajst-405	83	46	49	49	NUM
ajst-405	83	47	.	.	PUNCT
ajst-405	84	1	[	[	X
ajst-405	84	2	3	3	X
ajst-405	84	3	]	]	X
ajst-405	84	4	lei	lei	PROPN
ajst-405	84	5	liu	liu	PROPN
ajst-405	84	6	,	,	PUNCT
ajst-405	84	7	yunyun	yunyun	PROPN
ajst-405	84	8	qu	qu	PROPN
ajst-405	84	9	overview	overview	NOUN
ajst-405	84	10	and	and	CCONJ
ajst-405	84	11	application	application	NOUN
ajst-405	84	12	progress	progress	NOUN
ajst-405	84	13	of	of	ADP
ajst-405	84	14	chinese	chinese	ADJ
ajst-405	84	15	herbal	herbal	ADJ
ajst-405	84	16	suppositories	suppository	NOUN
ajst-405	84	17	[	[	X
ajst-405	84	18	j	j	X
ajst-405	84	19	]	]	X
ajst-405	84	20	heilongjiang	heilongjiang	PROPN
ajst-405	84	21	medicine	medicine	NOUN
ajst-405	84	22	,	,	PUNCT
ajst-405	84	23	2010	2010	NUM
ajst-405	84	24	,	,	PUNCT
ajst-405	84	25	23	23	NUM
ajst-405	84	26	(	(	PUNCT
ajst-405	84	27	01	01	NUM
ajst-405	84	28	):	):	PUNCT
ajst-405	84	29	98	98	NUM
ajst-405	84	30	-	-	SYM
ajst-405	84	31	100	100	NUM
ajst-405	84	32	doi:10.14035	doi:10.14035	NOUN
ajst-405	84	33	/	/	SYM
ajst-405	84	34	j.cnki	j.cnki	PROPN
ajst-405	84	35	.	.	PUNCT
ajst-405	85	1	hljyy	hljyy	PROPN
ajst-405	85	2	.	.	PUNCT
ajst-405	86	1	2010.01.011	2010.01.011	NUM
ajst-405	86	2	.	.	PUNCT
ajst-405	87	1	[	[	X
ajst-405	87	2	4	4	NUM
ajst-405	87	3	]	]	X
ajst-405	87	4	donde	donde	X
ajst-405	87	5	cai	cai	PROPN
ajst-405	87	6	a	a	DET
ajst-405	87	7	review	review	NOUN
ajst-405	87	8	of	of	ADP
ajst-405	87	9	traditional	traditional	ADJ
ajst-405	87	10	chinese	chinese	ADJ
ajst-405	87	11	medicine	medicine	NOUN
ajst-405	87	12	suppositories	suppository	NOUN
ajst-405	87	13	application	application	NOUN
ajst-405	87	14	[	[	X
ajst-405	87	15	j	j	X
ajst-405	87	16	]	]	X
ajst-405	87	17	journal	journal	PROPN
ajst-405	87	18	of	of	ADP
ajst-405	87	19	hubei	hubei	PROPN
ajst-405	87	20	academy	academy	PROPN
ajst-405	87	21	of	of	ADP
ajst-405	87	22	traditional	traditional	ADJ
ajst-405	87	23	chinese	chinese	ADJ
ajst-405	87	24	medicine	medicine	NOUN
ajst-405	87	25	,	,	PUNCT
ajst-405	87	26	2005	2005	NUM
ajst-405	87	27	(	(	PUNCT
ajst-405	87	28	04	04	NUM
ajst-405	87	29	):	):	PUNCT
ajst-405	87	30	58	58	NUM
ajst-405	87	31	-	-	SYM
ajst-405	87	32	60	60	NUM
ajst-405	87	33	.	.	PUNCT
ajst-405	88	1	[	[	X
ajst-405	88	2	5	5	NUM
ajst-405	88	3	]	]	PUNCT
ajst-405	88	4	qiu	qiu	PROPN
ajst-405	88	5	gui	gui	PROPN
ajst-405	88	6	zhou	zhou	PROPN
ajst-405	88	7	,	,	PUNCT
ajst-405	88	8	zeng	zeng	PROPN
ajst-405	88	9	hong	hong	PROPN
ajst-405	88	10	,	,	PUNCT
ajst-405	88	11	bing	bing	VERB
ajst-405	88	12	liu	liu	PROPN
ajst-405	88	13	preparation	preparation	NOUN
ajst-405	88	14	process	process	NOUN
ajst-405	88	15	of	of	ADP
ajst-405	88	16	aspirin	aspirin	NOUN
ajst-405	88	17	upper	upper	ADJ
ajst-405	88	18	and	and	CCONJ
ajst-405	88	19	lower	low	ADJ
ajst-405	88	20	bilayer	bilayer	NOUN
ajst-405	88	21	suppositories	suppository	NOUN
ajst-405	88	22	with	with	ADP
ajst-405	88	23	different	different	ADJ
ajst-405	88	24	matrix	matrix	NOUN
ajst-405	88	25	properties	property	NOUN
ajst-405	88	26	to	to	PART
ajst-405	88	27	explore	explore	VERB
ajst-405	88	28	[	[	X
ajst-405	88	29	j	j	X
ajst-405	88	30	]	]	X
ajst-405	88	31	jing	jing	PROPN
ajst-405	88	32	gang	gang	PROPN
ajst-405	88	33	shan	shan	PROPN
ajst-405	88	34	university	university	PROPN
ajst-405	88	35	journal	journal	NOUN
ajst-405	88	36	(	(	PUNCT
ajst-405	88	37	natural	natural	ADJ
ajst-405	88	38	science	science	NOUN
ajst-405	88	39	edition	edition	NOUN
ajst-405	88	40	)	)	PUNCT
ajst-405	88	41	,	,	PUNCT
ajst-405	88	42	2015	2015	NUM
ajst-405	88	43	,	,	PUNCT
ajst-405	88	44	36	36	NUM
ajst-405	88	45	(	(	PUNCT
ajst-405	88	46	04	04	NUM
ajst-405	88	47	):	):	PUNCT
ajst-405	88	48	9497	9497	NUM
ajst-405	88	49	.	.	PUNCT
ajst-405	89	1	[	[	X
ajst-405	89	2	6	6	NUM
ajst-405	89	3	]	]	PUNCT
ajst-405	89	4	youjuan	youjuan	NOUN
ajst-405	89	5	zhang	zhang	PROPN
ajst-405	89	6	preliminary	preliminary	ADJ
ajst-405	89	7	pharmaceutical	pharmaceutical	ADJ
ajst-405	89	8	studies	study	NOUN
ajst-405	89	9	on	on	ADP
ajst-405	89	10	bitter	bitter	ADJ
ajst-405	89	11	bean	bean	NOUN
ajst-405	89	12	alkaloid	alkaloid	PROPN
ajst-405	89	13	bilayer	bilayer	NOUN
ajst-405	89	14	suppositories	suppository	NOUN
ajst-405	89	15	[	[	X
ajst-405	89	16	d	d	X
ajst-405	89	17	]	]	X
ajst-405	89	18	chengdu	chengdu	PROPN
ajst-405	89	19	university	university	PROPN
ajst-405	89	20	of	of	ADP
ajst-405	89	21	traditional	traditional	ADJ
ajst-405	89	22	chinese	chinese	ADJ
ajst-405	89	23	medicine	medicine	NOUN
ajst-405	89	24	,	,	PUNCT
ajst-405	89	25	2016	2016	NUM
ajst-405	89	26	.	.	PUNCT
ajst-405	90	1	[	[	X
ajst-405	90	2	7	7	X
ajst-405	90	3	]	]	X
ajst-405	90	4	haiyu	haiyu	PROPN
ajst-405	90	5	pan	pan	PROPN
ajst-405	90	6	,	,	PUNCT
ajst-405	90	7	epicardia	epicardia	PROPN
ajst-405	90	8	meng	meng	PROPN
ajst-405	90	9	,	,	PUNCT
ajst-405	90	10	chunyan	chunyan	PROPN
ajst-405	90	11	liu	liu	PROPN
ajst-405	90	12	nimesulide	nimesulide	PROPN
ajst-405	90	13	suppository	suppository	PROPN
ajst-405	90	14	and	and	CCONJ
ajst-405	90	15	hollow	hollow	ADJ
ajst-405	90	16	suppository	suppository	NOUN
ajst-405	90	17	were	be	AUX
ajst-405	90	18	developed	develop	VERB
ajst-405	90	19	[	[	X
ajst-405	90	20	j	j	X
ajst-405	90	21	]	]	X
ajst-405	90	22	china	china	PROPN
ajst-405	90	23	pharm	pharm	PROPN
ajst-405	90	24	.	.	PUNCT
ajst-405	91	1	,	,	PUNCT
ajst-405	92	1	2006	2006	NUM
ajst-405	92	2	(	(	PUNCT
ajst-405	92	3	04	04	NUM
ajst-405	92	4	):	):	PUNCT
ajst-405	92	5	220	220	NUM
ajst-405	92	6	-	-	SYM
ajst-405	92	7	222	222	NUM
ajst-405	92	8	.	.	PUNCT
ajst-405	93	1	[	[	X
ajst-405	93	2	8	8	NUM
ajst-405	93	3	]	]	X
ajst-405	93	4	chen	chen	PROPN
ajst-405	93	5	penghao	penghao	PROPN
ajst-405	93	6	,	,	PUNCT
ajst-405	93	7	jiao	jiao	PROPN
ajst-405	93	8	j1	j1	PROPN
ajst-405	93	9	,	,	PUNCT
ajst-405	93	10	wang	wang	PROPN
ajst-405	93	11	chenxi	chenxi	PROPN
ajst-405	93	12	,	,	PUNCT
ajst-405	93	13	sui	sui	PROPN
ajst-405	93	14	xiaoyu	xiaoyu	PROPN
ajst-405	93	15	,	,	PUNCT
ajst-405	93	16	jiang	jiang	PROPN
ajst-405	93	17	fan	fan	PROPN
ajst-405	93	18	preparation	preparation	PROPN
ajst-405	93	19	and	and	CCONJ
ajst-405	93	20	quality	quality	NOUN
ajst-405	93	21	evaluation	evaluation	NOUN
ajst-405	93	22	of	of	ADP
ajst-405	93	23	hollow	hollow	ADJ
ajst-405	93	24	suppositories	suppository	NOUN
ajst-405	93	25	of	of	ADP
ajst-405	93	26	ibuprofen	ibuprofen	NOUN
ajst-405	93	27	for	for	ADP
ajst-405	93	28	pediatric	pediatric	ADJ
ajst-405	93	29	use	use	NOUN
ajst-405	93	30	[	[	X
ajst-405	93	31	j	j	X
ajst-405	93	32	]	]	X
ajst-405	93	33	chinese	chinese	ADJ
ajst-405	93	34	journal	journal	PROPN
ajst-405	93	35	of	of	ADP
ajst-405	93	36	pharmaceutical	pharmaceutical	NOUN
ajst-405	93	37	industry	industry	NOUN
ajst-405	93	38	,	,	PUNCT
ajst-405	93	39	2016	2016	NUM
ajst-405	93	40	,	,	PUNCT
ajst-405	93	41	47	47	NUM
ajst-405	93	42	(	(	PUNCT
ajst-405	93	43	10	10	NUM
ajst-405	93	44	):	):	PUNCT
ajst-405	93	45	1280	1280	NUM
ajst-405	93	46	-	-	SYM
ajst-405	93	47	1283	1283	NUM
ajst-405	93	48	doi:10.16522	doi:10.16522	NOUN
ajst-405	93	49	/	/	SYM
ajst-405	93	50	j.cnki	j.cnki	PROPN
ajst-405	93	51	.	.	PUNCT
ajst-405	94	1	cjph	cjph	PROPN
ajst-405	94	2	.	.	PUNCT
ajst-405	95	1	2016.10.016	2016.10.016	NUM
ajst-405	95	2	.	.	PUNCT
ajst-405	96	1	[	[	X
ajst-405	96	2	9	9	NUM
ajst-405	96	3	]	]	PUNCT
ajst-405	96	4	demin	demin	NOUN
ajst-405	96	5	wu	wu	PROPN
ajst-405	96	6	preparation	preparation	NOUN
ajst-405	96	7	and	and	CCONJ
ajst-405	96	8	quality	quality	NOUN
ajst-405	96	9	standard	standard	ADJ
ajst-405	96	10	study	study	NOUN
ajst-405	96	11	of	of	ADP
ajst-405	96	12	glucosamine	glucosamine	NOUN
ajst-405	96	13	plain	plain	ADJ
ajst-405	96	14	suppositories	suppository	NOUN
ajst-405	96	15	and	and	CCONJ
ajst-405	96	16	hollow	hollow	ADJ
ajst-405	96	17	suppositories	suppository	NOUN
ajst-405	96	18	[	[	X
ajst-405	96	19	d	d	X
ajst-405	96	20	]	]	X
ajst-405	96	21	anhui	anhui	PROPN
ajst-405	96	22	medical	medical	PROPN
ajst-405	96	23	university	university	PROPN
ajst-405	96	24	,	,	PUNCT
ajst-405	96	25	2013	2013	NUM
ajst-405	96	26	.	.	PUNCT
ajst-405	97	1	[	[	X
ajst-405	97	2	10	10	NUM
ajst-405	97	3	]	]	X
ajst-405	97	4	sheng	sheng	PROPN
ajst-405	97	5	male	male	PROPN
ajst-405	97	6	meng	meng	PROPN
ajst-405	97	7	,	,	PUNCT
ajst-405	97	8	qiu	qiu	PROPN
ajst-405	97	9	wang	wang	PROPN
ajst-405	97	10	,	,	PUNCT
ajst-405	97	11	yang	yang	PROPN
ajst-405	97	12	liu	liu	PROPN
ajst-405	97	13	,	,	PUNCT
ajst-405	97	14	wan	wan	PROPN
ajst-405	97	15	yu	yu	PROPN
ajst-405	97	16	feng	feng	PROPN
ajst-405	97	17	development	development	PROPN
ajst-405	97	18	and	and	CCONJ
ajst-405	97	19	clinical	clinical	ADJ
ajst-405	97	20	application	application	NOUN
ajst-405	97	21	of	of	ADP
ajst-405	97	22	a	a	DET
ajst-405	97	23	sponge	sponge	NOUN
ajst-405	97	24	vaginal	vaginal	ADJ
ajst-405	97	25	plug	plug	NOUN
ajst-405	97	26	of	of	ADP
ajst-405	97	27	tinidazole	tinidazole	NOUN
ajst-405	97	28	[	[	X
ajst-405	97	29	j	j	X
ajst-405	97	30	]	]	X
ajst-405	97	31	chinese	chinese	ADJ
ajst-405	97	32	journal	journal	PROPN
ajst-405	97	33	of	of	ADP
ajst-405	97	34	antibiotics	antibiotic	NOUN
ajst-405	97	35	,	,	PUNCT
ajst-405	97	36	2003	2003	NUM
ajst-405	97	37	(	(	PUNCT
ajst-405	97	38	06	06	NUM
ajst-405	97	39	):	):	PUNCT
ajst-405	97	40	376377	376377	NUM
ajst-405	97	41	.	.	PUNCT
ajst-405	98	1	[	[	X
ajst-405	98	2	11	11	NUM
ajst-405	98	3	]	]	PUNCT
ajst-405	98	4	xu	xu	PROPN
ajst-405	98	5	zya	zya	PROPN
ajst-405	98	6	,	,	PUNCT
ajst-405	98	7	chen	chen	PROPN
ajst-405	98	8	jiyue	jiyue	PROPN
ajst-405	98	9	,	,	PUNCT
ajst-405	98	10	li	li	PROPN
ajst-405	98	11	qiyun	qiyun	PROPN
ajst-405	98	12	,	,	PUNCT
ajst-405	98	13	shu	shu	PROPN
ajst-405	98	14	wei	wei	PROPN
ajst-405	98	15	,	,	PUNCT
ajst-405	98	16	wu	wu	PROPN
ajst-405	98	17	wy	wy	PROPN
ajst-405	98	18	an	an	DET
ajst-405	98	19	experimental	experimental	ADJ
ajst-405	98	20	study	study	NOUN
ajst-405	98	21	of	of	ADP
ajst-405	98	22	metronidazole	metronidazole	NOUN
ajst-405	98	23	gelfoam	gelfoam	NOUN
ajst-405	98	24	vaginal	vaginal	ADJ
ajst-405	98	25	suppositories	suppository	NOUN
ajst-405	98	26	[	[	X
ajst-405	98	27	j	j	X
ajst-405	98	28	]	]	X
ajst-405	98	29	journal	journal	NOUN
ajst-405	98	30	of	of	ADP
ajst-405	98	31	chinese	chinese	ADJ
ajst-405	98	32	hospital	hospital	NOUN
ajst-405	98	33	pharmacy	pharmacy	NOUN
ajst-405	98	34	,	,	PUNCT
ajst-405	98	35	1994	1994	NUM
ajst-405	98	36	(	(	PUNCT
ajst-405	98	37	09	09	NUM
ajst-405	98	38	):	):	PUNCT
ajst-405	98	39	387	387	NUM
ajst-405	98	40	-	-	SYM
ajst-405	98	41	389	389	NUM
ajst-405	98	42	+	+	NUM
ajst-405	98	43	430	430	NUM
ajst-405	98	44	.	.	PUNCT
ajst-405	99	1	[	[	X
ajst-405	99	2	12	12	NUM
ajst-405	99	3	]	]	X
ajst-405	99	4	yihua	yihua	PROPN
ajst-405	99	5	yang	yang	PROPN
ajst-405	99	6	,	,	PUNCT
ajst-405	99	7	yi	yi	PROPN
ajst-405	99	8	liu	liu	PROPN
ajst-405	99	9	,	,	PUNCT
ajst-405	99	10	ziming	zime	VERB
ajst-405	99	11	zhao	zhao	NOUN
ajst-405	99	12	,	,	PUNCT
ajst-405	99	13	yaling	yaling	NOUN
ajst-405	99	14	song	song	NOUN
ajst-405	99	15	,	,	PUNCT
ajst-405	99	16	jie	jie	PROPN
ajst-405	99	17	wang	wang	PROPN
ajst-405	99	18	,	,	PUNCT
ajst-405	99	19	jiale	jiale	PROPN
ajst-405	99	20	yin	yin	PROPN
ajst-405	99	21	preparation	preparation	NOUN
ajst-405	99	22	of	of	ADP
ajst-405	99	23	naproxen	naproxen	PROPN
ajst-405	99	24	microcapsule	microcapsule	NOUN
ajst-405	99	25	plugs	plug	NOUN
ajst-405	99	26	and	and	CCONJ
ajst-405	99	27	their	their	PRON
ajst-405	99	28	quality	quality	NOUN
ajst-405	99	29	control	control	NOUN
ajst-405	99	30	[	[	X
ajst-405	99	31	j	j	X
ajst-405	99	32	]	]	X
ajst-405	99	33	pharmacy	pharmacy	NOUN
ajst-405	99	34	,	,	PUNCT
ajst-405	99	35	china	china	PROPN
ajst-405	99	36	,	,	PUNCT
ajst-405	99	37	2011	2011	NUM
ajst-405	99	38	,	,	PUNCT
ajst-405	99	39	22	22	NUM
ajst-405	99	40	(	(	PUNCT
ajst-405	99	41	25	25	NUM
ajst-405	99	42	):	):	PUNCT
ajst-405	99	43	2363	2363	NUM
ajst-405	99	44	-	-	SYM
ajst-405	99	45	2365	2365	NUM
ajst-405	99	46	.	.	PUNCT
ajst-405	100	1	[	[	X
ajst-405	100	2	13	13	NUM
ajst-405	100	3	]	]	X
ajst-405	100	4	lei	lei	PROPN
ajst-405	100	5	wang	wang	PROPN
ajst-405	100	6	,	,	PUNCT
ajst-405	100	7	sihai	sihai	PROPN
ajst-405	100	8	ding	ding	PROPN
ajst-405	100	9	,	,	PUNCT
ajst-405	100	10	xiuru	xiuru	PROPN
ajst-405	100	11	liu	liu	PROPN
ajst-405	100	12	,	,	PUNCT
ajst-405	100	13	yu	yu	PROPN
ajst-405	100	14	jie	jie	PROPN
ajst-405	100	15	niu	niu	PROPN
ajst-405	100	16	and	and	CCONJ
ajst-405	100	17	cuiyan	cuiyan	PROPN
ajst-405	100	18	han	han	PROPN
ajst-405	100	19	preparation	preparation	NOUN
ajst-405	100	20	and	and	CCONJ
ajst-405	100	21	in	in	ADP
ajst-405	100	22	vitro	vitro	X
ajst-405	100	23	release	release	NOUN
ajst-405	100	24	profile	profile	NOUN
ajst-405	100	25	of	of	ADP
ajst-405	100	26	paracetamol	paracetamol	NOUN
ajst-405	100	27	compounded	compound	VERB
ajst-405	100	28	microcapsule	microcapsule	NOUN
ajst-405	100	29	sustained	sustain	VERB
ajst-405	100	30	release	release	NOUN
ajst-405	100	31	plugs	plug	NOUN
ajst-405	100	32	[	[	X
ajst-405	100	33	j	j	X
ajst-405	100	34	]	]	X
ajst-405	100	35	journal	journal	NOUN
ajst-405	100	36	of	of	ADP
ajst-405	100	37	chinese	chinese	ADJ
ajst-405	100	38	hospital	hospital	NOUN
ajst-405	100	39	pharmacy	pharmacy	NOUN
ajst-405	100	40	,	,	PUNCT
ajst-405	100	41	2016,36	2016,36	NUM
ajst-405	100	42	(	(	PUNCT
ajst-405	100	43	09	09	NUM
ajst-405	100	44	):	):	PUNCT
ajst-405	100	45	714	714	NUM
ajst-405	100	46	-	-	SYM
ajst-405	100	47	718	718	NUM
ajst-405	100	48	doi:10.13286	doi:10.13286	NOUN
ajst-405	100	49	/	/	SYM
ajst-405	100	50	j.cnki	j.cnki	PROPN
ajst-405	100	51	.	.	PUNCT
ajst-405	101	1	chinhosppharmacyj	chinhosppharmacyj	NOUN
ajst-405	101	2	.	.	PUNCT
ajst-405	102	1	2016.09.04	2016.09.04	NUM
ajst-405	102	2	.	.	PUNCT
ajst-405	103	1	[	[	X
ajst-405	103	2	14	14	NUM
ajst-405	103	3	]	]	X
ajst-405	103	4	junyong	junyong	PROPN
ajst-405	103	5	jiang	jiang	PROPN
ajst-405	103	6	,	,	PUNCT
ajst-405	103	7	yanan	yanan	PROPN
ajst-405	103	8	zhou	zhou	PROPN
ajst-405	103	9	,	,	PUNCT
ajst-405	103	10	chuanbin	chuanbin	NOUN
ajst-405	103	11	gu	gu	NOUN
ajst-405	103	12	and	and	CCONJ
ajst-405	103	13	xiaogui	xiaogui	PROPN
ajst-405	103	14	pan	pan	PROPN
ajst-405	103	15	preparation	preparation	NOUN
ajst-405	103	16	and	and	CCONJ
ajst-405	103	17	quality	quality	NOUN
ajst-405	103	18	control	control	NOUN
ajst-405	103	19	of	of	ADP
ajst-405	103	20	danazol	danazol	ADJ
ajst-405	103	21	effervescent	effervescent	ADJ
ajst-405	103	22	plugs	plug	NOUN
ajst-405	103	23	[	[	X
ajst-405	103	24	j	j	X
ajst-405	103	25	]	]	X
ajst-405	103	26	pharmacy	pharmacy	NOUN
ajst-405	103	27	,	,	PUNCT
ajst-405	103	28	china	china	PROPN
ajst-405	103	29	,	,	PUNCT
ajst-405	103	30	2004	2004	NUM
ajst-405	103	31	(	(	PUNCT
ajst-405	103	32	07	07	NUM
ajst-405	103	33	):	):	PUNCT
ajst-405	103	34	26	26	NUM
ajst-405	103	35	-	-	SYM
ajst-405	103	36	27	27	NUM
ajst-405	103	37	.	.	PUNCT
ajst-405	104	1	[	[	X
ajst-405	104	2	15	15	NUM
ajst-405	104	3	]	]	X
ajst-405	104	4	kai	kai	PROPN
ajst-405	104	5	li	li	PROPN
ajst-405	104	6	zhang	zhang	PROPN
ajst-405	104	7	,	,	PUNCT
ajst-405	104	8	cheng	cheng	PROPN
ajst-405	104	9	li	li	PROPN
ajst-405	104	10	,	,	PUNCT
ajst-405	104	11	chun	chun	PROPN
ajst-405	104	12	zhi	zhi	PROPN
ajst-405	104	13	yang	yang	PROPN
ajst-405	104	14	,	,	PUNCT
ajst-405	104	15	yi	yi	PROPN
ajst-405	104	16	jian	jian	PROPN
ajst-405	104	17	zhang	zhang	PROPN
ajst-405	104	18	,	,	PUNCT
ajst-405	104	19	shi	shi	PROPN
ajst-405	104	20	liang	liang	PROPN
ajst-405	104	21	liao	liao	PROPN
ajst-405	104	22	and	and	CCONJ
ajst-405	104	23	feng	feng	PROPN
ajst-405	104	24	feng	feng	PROPN
ajst-405	104	25	ming	ming	PROPN
ajst-405	104	26	preparation	preparation	PROPN
ajst-405	104	27	and	and	CCONJ
ajst-405	104	28	quality	quality	NOUN
ajst-405	104	29	control	control	NOUN
ajst-405	104	30	of	of	ADP
ajst-405	104	31	povidone	povidone	NOUN
ajst-405	104	32	iodophore	iodophore	ADJ
ajst-405	104	33	suppositories	suppository	NOUN
ajst-405	104	34	[	[	X
ajst-405	104	35	j	j	X
ajst-405	104	36	]	]	X
ajst-405	104	37	str	str	VERB
ajst-405	104	38	pharm	pharm	PROPN
ajst-405	104	39	.	.	PUNCT
ajst-405	104	40	,	,	PUNCT
ajst-405	104	41	2014	2014	NUM
ajst-405	104	42	,	,	PUNCT
ajst-405	104	43	26	26	NUM
ajst-405	104	44	(	(	PUNCT
ajst-405	104	45	06	06	NUM
ajst-405	104	46	):	):	PUNCT
ajst-405	104	47	25	25	NUM
ajst-405	104	48	-	-	SYM
ajst-405	104	49	27	27	NUM
ajst-405	104	50	.	.	PUNCT
ajst-405	105	1	[	[	X
ajst-405	105	2	16	16	NUM
ajst-405	105	3	]	]	X
ajst-405	105	4	chen	chen	PROPN
ajst-405	105	5	xm	xm	PROPN
ajst-405	105	6	,	,	PUNCT
ajst-405	105	7	sun	sun	PROPN
ajst-405	105	8	wd	wd	PROPN
ajst-405	105	9	,	,	PUNCT
ajst-405	105	10	gao	gao	PROPN
ajst-405	105	11	xli	xli	PROPN
ajst-405	105	12	overview	overview	NOUN
ajst-405	105	13	of	of	ADP
ajst-405	105	14	rectal	rectal	ADJ
ajst-405	105	15	suppository	suppository	ADJ
ajst-405	105	16	studies	study	NOUN
ajst-405	105	17	[	[	X
ajst-405	105	18	j	j	X
ajst-405	105	19	]	]	X
ajst-405	105	20	northwest	northwest	PROPN
ajst-405	105	21	j	j	PROPN
ajst-405	105	22	pharm	pharm	PROPN
ajst-405	105	23	.	.	PUNCT
ajst-405	105	24	,	,	PUNCT
ajst-405	105	25	2004	2004	NUM
ajst-405	105	26	(	(	PUNCT
ajst-405	105	27	03	03	NUM
ajst-405	105	28	):	):	PUNCT
ajst-405	105	29	143	143	NUM
ajst-405	105	30	-	-	SYM
ajst-405	105	31	144	144	NUM
ajst-405	105	32	.	.	PUNCT
ajst-405	106	1	[	[	X
ajst-405	106	2	17	17	NUM
ajst-405	106	3	]	]	X
ajst-405	106	4	huoxiaomei	huoxiaomei	PROPN
ajst-405	106	5	,	,	PUNCT
ajst-405	106	6	yangui	yangui	PROPN
ajst-405	106	7	li	li	PROPN
ajst-405	106	8	,	,	PUNCT
ajst-405	106	9	jinghong	jinghong	PROPN
ajst-405	106	10	qu	qu	PROPN
ajst-405	106	11	in	in	ADP
ajst-405	106	12	vitro	vitro	X
ajst-405	106	13	release	release	NOUN
ajst-405	106	14	profile	profile	NOUN
ajst-405	106	15	of	of	ADP
ajst-405	106	16	compound	compound	NOUN
ajst-405	106	17	tinidazole	tinidazole	NOUN
ajst-405	106	18	hydrogel	hydrogel	NOUN
ajst-405	106	19	plugs	plug	VERB
ajst-405	106	20	[	[	X
ajst-405	106	21	j	j	X
ajst-405	106	22	]	]	X
ajst-405	106	23	shanxi	shanxi	PROPN
ajst-405	106	24	medical	medical	PROPN
ajst-405	106	25	journal	journal	PROPN
ajst-405	106	26	,	,	PUNCT
ajst-405	106	27	2012	2012	NUM
ajst-405	106	28	,	,	PUNCT
ajst-405	106	29	41	41	NUM
ajst-405	106	30	(	(	PUNCT
ajst-405	106	31	11	11	NUM
ajst-405	106	32	):	):	PUNCT
ajst-405	106	33	1159	1159	NUM
ajst-405	106	34	-	-	SYM
ajst-405	106	35	1160	1160	NUM
ajst-405	106	36	.	.	PUNCT
ajst-405	107	1	[	[	X
ajst-405	107	2	18	18	NUM
ajst-405	107	3	]	]	X
ajst-405	107	4	shexiang	shexiang	PROPN
ajst-405	107	5	li	li	PROPN
ajst-405	107	6	,	,	PUNCT
ajst-405	107	7	xiaolun	xiaolun	PROPN
ajst-405	107	8	liu	liu	PROPN
ajst-405	107	9	,	,	PUNCT
ajst-405	107	10	qiang	qiang	PROPN
ajst-405	107	11	bao	bao	PROPN
ajst-405	107	12	,	,	PUNCT
ajst-405	107	13	zhengguo	zhengguo	PROPN
ajst-405	107	14	xiao	xiao	PROPN
ajst-405	107	15	novel	novel	PROPN
ajst-405	107	16	suppository	suppository	ADJ
ajst-405	107	17	preparation	preparation	NOUN
ajst-405	107	18	process	process	NOUN
ajst-405	107	19	and	and	CCONJ
ajst-405	107	20	its	its	PRON
ajst-405	107	21	pharmacokinetic	pharmacokinetic	ADJ
ajst-405	107	22	characterization	characterization	NOUN
ajst-405	107	23	progress	progress	NOUN
ajst-405	107	24	[	[	X
ajst-405	107	25	j	j	X
ajst-405	107	26	]	]	X
ajst-405	107	27	china	china	PROPN
ajst-405	107	28	pharmaceutical	pharmaceutical	PROPN
ajst-405	107	29	,	,	PUNCT
ajst-405	107	30	2013	2013	NUM
ajst-405	107	31	,	,	PUNCT
ajst-405	107	32	27	27	NUM
ajst-405	107	33	(	(	PUNCT
ajst-405	107	34	07	07	NUM
ajst-405	107	35	):	):	PUNCT
ajst-405	107	36	740	740	NUM
ajst-405	107	37	-	-	SYM
ajst-405	107	38	744	744	NUM
ajst-405	107	39	doi:10.16153	doi:10.16153	NOUN
ajst-405	107	40	/	/	SYM
ajst-405	107	41	j.1002	j.1002	NOUN
ajst-405	107	42	-	-	PUNCT
ajst-405	107	43	7777.2013.07.002	7777.2013.07.002	NOUN
ajst-405	107	44	.	.	PUNCT
ajst-405	108	1	[	[	X
ajst-405	108	2	19	19	NUM
ajst-405	108	3	]	]	PUNCT
ajst-405	108	4	yongshun	yongshun	PROPN
ajst-405	108	5	chen	chen	PROPN
ajst-405	108	6	,	,	PUNCT
ajst-405	108	7	fang	fang	PROPN
ajst-405	108	8	chen	chen	PROPN
ajst-405	108	9	,	,	PUNCT
ajst-405	108	10	fang	fang	PROPN
ajst-405	108	11	chen	chen	PROPN
ajst-405	108	12	,	,	PUNCT
ajst-405	108	13	shih	shih	PROPN
ajst-405	108	14	ming	ming	PROPN
ajst-405	108	15	du	du	PROPN
ajst-405	108	16	,	,	PUNCT
ajst-405	108	17	qibin	qibin	NOUN
ajst-405	108	18	wang	wang	PROPN
ajst-405	108	19	development	development	PROPN
ajst-405	108	20	of	of	ADP
ajst-405	108	21	sustained	sustained	ADJ
ajst-405	108	22	release	release	NOUN
ajst-405	108	23	plugs	plug	NOUN
ajst-405	108	24	for	for	ADP
ajst-405	108	25	indomethacin	indomethacin	NOUN
ajst-405	108	26	and	and	CCONJ
ajst-405	108	27	determination	determination	NOUN
ajst-405	108	28	of	of	ADP
ajst-405	108	29	its	its	PRON
ajst-405	108	30	bioavailability	bioavailability	NOUN
ajst-405	108	31	[	[	X
ajst-405	108	32	j	j	X
ajst-405	108	33	]	]	X
ajst-405	108	34	journal	journal	NOUN
ajst-405	108	35	of	of	ADP
ajst-405	108	36	chinese	chinese	ADJ
ajst-405	108	37	hospital	hospital	NOUN
ajst-405	108	38	pharmacy	pharmacy	NOUN
ajst-405	108	39	,	,	PUNCT
ajst-405	108	40	2009	2009	NUM
ajst-405	108	41	,	,	PUNCT
ajst-405	108	42	29	29	NUM
ajst-405	108	43	(	(	PUNCT
ajst-405	108	44	04	04	NUM
ajst-405	108	45	):	):	PUNCT
ajst-405	108	46	296	296	NUM
ajst-405	108	47	-	-	SYM
ajst-405	108	48	299	299	NUM
ajst-405	108	49	.	.	PUNCT
ajst-405	109	1	[	[	X
ajst-405	109	2	20	20	NUM
ajst-405	109	3	]	]	PUNCT
ajst-405	109	4	he	he	PRON
ajst-405	109	5	xin	xin	PROPN
ajst-405	109	6	,	,	PUNCT
ajst-405	109	7	shi	shi	PROPN
ajst-405	109	8	chun	chun	PROPN
ajst-405	109	9	wei	wei	PROPN
ajst-405	109	10	,	,	PUNCT
ajst-405	109	11	zhang	zhang	PROPN
ajst-405	109	12	chuang	chuang	PROPN
ajst-405	109	13	,	,	PUNCT
ajst-405	109	14	liu	liu	PROPN
ajst-405	109	15	xueting	xueting	PROPN
ajst-405	109	16	,	,	PUNCT
ajst-405	109	17	ming	ming	PROPN
ajst-405	109	18	ming	ming	PROPN
ajst-405	109	19	ma	ma	PROPN
ajst-405	109	20	,	,	PUNCT
ajst-405	109	21	meng	meng	PROPN
ajst-405	109	22	yao	yao	PROPN
ajst-405	109	23	du	du	PROPN
ajst-405	109	24	preparation	preparation	NOUN
ajst-405	109	25	and	and	CCONJ
ajst-405	109	26	in	in	ADP
ajst-405	109	27	vitro	vitro	X
ajst-405	109	28	release	release	NOUN
ajst-405	109	29	profile	profile	NOUN
ajst-405	109	30	of	of	ADP
ajst-405	109	31	compound	compound	NOUN
ajst-405	109	32	metronidazole	metronidazole	NOUN
ajst-405	109	33	sustained	sustain	VERB
ajst-405	109	34	release	release	NOUN
ajst-405	109	35	thrombus	thrombus	NOUN
ajst-405	109	36	[	[	X
ajst-405	109	37	j	j	X
ajst-405	109	38	]	]	X
ajst-405	109	39	pharmacy	pharmacy	NOUN
ajst-405	109	40	,	,	PUNCT
ajst-405	109	41	china	china	PROPN
ajst-405	109	42	,	,	PUNCT
ajst-405	109	43	2011	2011	NUM
ajst-405	109	44	,	,	PUNCT
ajst-405	109	45	22	22	NUM
ajst-405	109	46	(	(	PUNCT
ajst-405	109	47	09	09	NUM
ajst-405	109	48	):	):	PUNCT
ajst-405	109	49	834	834	NUM
ajst-405	109	50	-	-	SYM
ajst-405	109	51	836	836	NUM
ajst-405	109	52	.	.	PUNCT