id	sid	tid	token	lemma	pos
ajst-6290	1	1	academic	academic	ADJ
ajst-6290	1	2	journal	journal	NOUN
ajst-6290	1	3	of	of	ADP
ajst-6290	1	4	science	science	NOUN
ajst-6290	1	5	and	and	CCONJ
ajst-6290	1	6	technology	technology	NOUN
ajst-6290	1	7	issn	issn	NOUN
ajst-6290	1	8	:	:	PUNCT
ajst-6290	1	9	2771	2771	NUM
ajst-6290	1	10	-	-	SYM
ajst-6290	1	11	3032	3032	NUM
ajst-6290	1	12	|	|	NOUN
ajst-6290	1	13	vol	vol	NOUN
ajst-6290	1	14	.	.	PROPN
ajst-6290	2	1	5	5	NUM
ajst-6290	2	2	,	,	PUNCT
ajst-6290	2	3	no	no	INTJ
ajst-6290	2	4	.	.	NOUN
ajst-6290	2	5	2	2	NUM
ajst-6290	2	6	,	,	PUNCT
ajst-6290	2	7	2023	2023	NUM
ajst-6290	2	8	95	95	NUM
ajst-6290	2	9	synthetic	synthetic	ADJ
ajst-6290	2	10	biology	biology	NOUN
ajst-6290	2	11	:	:	PUNCT
ajst-6290	2	12	from	from	ADP
ajst-6290	2	13	the	the	DET
ajst-6290	2	14	past	past	NOUN
ajst-6290	2	15	to	to	ADP
ajst-6290	2	16	the	the	DET
ajst-6290	2	17	future	future	ADJ
ajst-6290	2	18	fei	fei	PROPN
ajst-6290	2	19	wang1	wang1	PROPN
ajst-6290	2	20	,	,	PUNCT
ajst-6290	2	21	*	*	VERB
ajst-6290	2	22	1	1	NUM
ajst-6290	2	23	simcere	simcere	NOUN
ajst-6290	2	24	pharmaceutical	pharmaceutical	NOUN
ajst-6290	2	25	group	group	NOUN
ajst-6290	2	26	limited	limit	VERB
ajst-6290	2	27	,	,	PUNCT
ajst-6290	2	28	shanghai	shanghai	PROPN
ajst-6290	2	29	,	,	PUNCT
ajst-6290	2	30	china	china	PROPN
ajst-6290	2	31	*	*	PUNCT
ajst-6290	2	32	corresponding	correspond	VERB
ajst-6290	2	33	author	author	NOUN
ajst-6290	2	34	:	:	PUNCT
ajst-6290	2	35	fei	fei	PROPN
ajst-6290	2	36	wang	wang	PROPN
ajst-6290	2	37	(	(	PUNCT
ajst-6290	2	38	email	email	NOUN
ajst-6290	2	39	:	:	PUNCT
ajst-6290	2	40	19210700153@fudan.edu.cn	19210700153@fudan.edu.cn	NUM
ajst-6290	2	41	)	)	PUNCT
ajst-6290	2	42	abstract	abstract	NOUN
ajst-6290	2	43	:	:	PUNCT
ajst-6290	2	44	synthetic	synthetic	ADJ
ajst-6290	2	45	biology	biology	NOUN
ajst-6290	2	46	is	be	AUX
ajst-6290	2	47	a	a	DET
ajst-6290	2	48	highly	highly	ADV
ajst-6290	2	49	promising	promising	ADJ
ajst-6290	2	50	interdisciplinary	interdisciplinary	ADJ
ajst-6290	2	51	field	field	NOUN
ajst-6290	2	52	aimed	aim	VERB
ajst-6290	2	53	at	at	ADP
ajst-6290	2	54	integrating	integrate	VERB
ajst-6290	2	55	knowledge	knowledge	NOUN
ajst-6290	2	56	and	and	CCONJ
ajst-6290	2	57	techniques	technique	NOUN
ajst-6290	2	58	from	from	ADP
ajst-6290	2	59	various	various	ADJ
ajst-6290	2	60	disciplines	discipline	NOUN
ajst-6290	2	61	to	to	PART
ajst-6290	2	62	achieve	achieve	VERB
ajst-6290	2	63	precise	precise	ADJ
ajst-6290	2	64	control	control	NOUN
ajst-6290	2	65	and	and	CCONJ
ajst-6290	2	66	manipulation	manipulation	NOUN
ajst-6290	2	67	of	of	ADP
ajst-6290	2	68	biological	biological	ADJ
ajst-6290	2	69	systems	system	NOUN
ajst-6290	2	70	.	.	PUNCT
ajst-6290	3	1	since	since	SCONJ
ajst-6290	3	2	the	the	DET
ajst-6290	3	3	discovery	discovery	NOUN
ajst-6290	3	4	of	of	ADP
ajst-6290	3	5	dna	dna	PROPN
ajst-6290	3	6	structure	structure	NOUN
ajst-6290	3	7	by	by	ADP
ajst-6290	3	8	watson	watson	PROPN
ajst-6290	3	9	and	and	CCONJ
ajst-6290	3	10	crick	crick	NOUN
ajst-6290	3	11	in	in	ADP
ajst-6290	3	12	1953	1953	NUM
ajst-6290	3	13	,	,	PUNCT
ajst-6290	3	14	synthetic	synthetic	ADJ
ajst-6290	3	15	biology	biology	NOUN
ajst-6290	3	16	has	have	AUX
ajst-6290	3	17	undergone	undergo	VERB
ajst-6290	3	18	rapid	rapid	ADJ
ajst-6290	3	19	development	development	NOUN
ajst-6290	3	20	.	.	PUNCT
ajst-6290	4	1	during	during	ADP
ajst-6290	4	2	this	this	DET
ajst-6290	4	3	time	time	NOUN
ajst-6290	4	4	,	,	PUNCT
ajst-6290	4	5	synthetic	synthetic	ADJ
ajst-6290	4	6	biologists	biologist	NOUN
ajst-6290	4	7	have	have	AUX
ajst-6290	4	8	developed	develop	VERB
ajst-6290	4	9	numerous	numerous	ADJ
ajst-6290	4	10	tools	tool	NOUN
ajst-6290	4	11	and	and	CCONJ
ajst-6290	4	12	technologies	technology	NOUN
ajst-6290	4	13	to	to	PART
ajst-6290	4	14	better	well	ADV
ajst-6290	4	15	understand	understand	VERB
ajst-6290	4	16	biological	biological	ADJ
ajst-6290	4	17	systems	system	NOUN
ajst-6290	4	18	and	and	CCONJ
ajst-6290	4	19	to	to	PART
ajst-6290	4	20	develop	develop	VERB
ajst-6290	4	21	new	new	ADJ
ajst-6290	4	22	methods	method	NOUN
ajst-6290	4	23	for	for	ADP
ajst-6290	4	24	constructing	construct	VERB
ajst-6290	4	25	and	and	CCONJ
ajst-6290	4	26	manipulating	manipulate	VERB
ajst-6290	4	27	these	these	DET
ajst-6290	4	28	systems	system	NOUN
ajst-6290	4	29	.	.	PUNCT
ajst-6290	5	1	initially	initially	ADV
ajst-6290	5	2	,	,	PUNCT
ajst-6290	5	3	synthetic	synthetic	ADJ
ajst-6290	5	4	biology	biology	NOUN
ajst-6290	5	5	research	research	NOUN
ajst-6290	5	6	was	be	AUX
ajst-6290	5	7	mainly	mainly	ADV
ajst-6290	5	8	focused	focus	VERB
ajst-6290	5	9	on	on	ADP
ajst-6290	5	10	genetic	genetic	ADJ
ajst-6290	5	11	engineering	engineering	NOUN
ajst-6290	5	12	,	,	PUNCT
ajst-6290	5	13	with	with	ADP
ajst-6290	5	14	the	the	DET
ajst-6290	5	15	primary	primary	ADJ
ajst-6290	5	16	goal	goal	NOUN
ajst-6290	5	17	of	of	ADP
ajst-6290	5	18	inserting	insert	VERB
ajst-6290	5	19	artificially	artificially	ADV
ajst-6290	5	20	synthesized	synthesize	VERB
ajst-6290	5	21	dna	dna	NOUN
ajst-6290	5	22	into	into	ADP
ajst-6290	5	23	biological	biological	ADJ
ajst-6290	5	24	systems	system	NOUN
ajst-6290	5	25	to	to	PART
ajst-6290	5	26	achieve	achieve	VERB
ajst-6290	5	27	specific	specific	ADJ
ajst-6290	5	28	functions	function	NOUN
ajst-6290	5	29	.	.	PUNCT
ajst-6290	6	1	however	however	ADV
ajst-6290	6	2	,	,	PUNCT
ajst-6290	6	3	over	over	ADP
ajst-6290	6	4	time	time	NOUN
ajst-6290	6	5	,	,	PUNCT
ajst-6290	6	6	this	this	DET
ajst-6290	6	7	field	field	NOUN
ajst-6290	6	8	has	have	AUX
ajst-6290	6	9	become	become	VERB
ajst-6290	6	10	increasingly	increasingly	ADV
ajst-6290	6	11	complex	complex	ADJ
ajst-6290	6	12	,	,	PUNCT
ajst-6290	6	13	and	and	CCONJ
ajst-6290	6	14	researchers	researcher	NOUN
ajst-6290	6	15	have	have	AUX
ajst-6290	6	16	begun	begin	VERB
ajst-6290	6	17	exploring	explore	VERB
ajst-6290	6	18	broader	broad	ADJ
ajst-6290	6	19	issues	issue	NOUN
ajst-6290	6	20	,	,	PUNCT
ajst-6290	6	21	such	such	ADJ
ajst-6290	6	22	as	as	ADP
ajst-6290	6	23	how	how	SCONJ
ajst-6290	6	24	to	to	PART
ajst-6290	6	25	integrate	integrate	VERB
ajst-6290	6	26	biological	biological	ADJ
ajst-6290	6	27	and	and	CCONJ
ajst-6290	6	28	non	non	ADJ
ajst-6290	6	29	-	-	ADJ
ajst-6290	6	30	biological	biological	ADJ
ajst-6290	6	31	systems	system	NOUN
ajst-6290	6	32	and	and	CCONJ
ajst-6290	6	33	how	how	SCONJ
ajst-6290	6	34	to	to	PART
ajst-6290	6	35	use	use	VERB
ajst-6290	6	36	these	these	DET
ajst-6290	6	37	systems	system	NOUN
ajst-6290	6	38	for	for	ADP
ajst-6290	6	39	medical	medical	ADJ
ajst-6290	6	40	and	and	CCONJ
ajst-6290	6	41	environmental	environmental	ADJ
ajst-6290	6	42	applications	application	NOUN
ajst-6290	6	43	.	.	PUNCT
ajst-6290	7	1	in	in	ADP
ajst-6290	7	2	recent	recent	ADJ
ajst-6290	7	3	years	year	NOUN
ajst-6290	7	4	,	,	PUNCT
ajst-6290	7	5	synthetic	synthetic	ADJ
ajst-6290	7	6	biology	biology	NOUN
ajst-6290	7	7	research	research	NOUN
ajst-6290	7	8	has	have	AUX
ajst-6290	7	9	reached	reach	VERB
ajst-6290	7	10	new	new	ADJ
ajst-6290	7	11	heights	height	NOUN
ajst-6290	7	12	,	,	PUNCT
ajst-6290	7	13	involving	involve	VERB
ajst-6290	7	14	the	the	DET
ajst-6290	7	15	construction	construction	NOUN
ajst-6290	7	16	of	of	ADP
ajst-6290	7	17	artificially	artificially	ADV
ajst-6290	7	18	synthesized	synthesize	VERB
ajst-6290	7	19	genomes	genome	NOUN
ajst-6290	7	20	and	and	CCONJ
ajst-6290	7	21	cells	cell	NOUN
ajst-6290	7	22	,	,	PUNCT
ajst-6290	7	23	and	and	CCONJ
ajst-6290	7	24	how	how	SCONJ
ajst-6290	7	25	to	to	PART
ajst-6290	7	26	apply	apply	VERB
ajst-6290	7	27	these	these	DET
ajst-6290	7	28	systems	system	NOUN
ajst-6290	7	29	to	to	ADP
ajst-6290	7	30	medical	medical	ADJ
ajst-6290	7	31	,	,	PUNCT
ajst-6290	7	32	energy	energy	NOUN
ajst-6290	7	33	,	,	PUNCT
ajst-6290	7	34	and	and	CCONJ
ajst-6290	7	35	environmental	environmental	ADJ
ajst-6290	7	36	fields	field	NOUN
ajst-6290	7	37	.	.	PUNCT
ajst-6290	8	1	these	these	DET
ajst-6290	8	2	research	research	NOUN
ajst-6290	8	3	achievements	achievement	NOUN
ajst-6290	8	4	offer	offer	VERB
ajst-6290	8	5	enormous	enormous	ADJ
ajst-6290	8	6	potential	potential	NOUN
ajst-6290	8	7	for	for	ADP
ajst-6290	8	8	treating	treat	VERB
ajst-6290	8	9	diseases	disease	NOUN
ajst-6290	8	10	,	,	PUNCT
ajst-6290	8	11	reducing	reduce	VERB
ajst-6290	8	12	pollution	pollution	NOUN
ajst-6290	8	13	,	,	PUNCT
ajst-6290	8	14	and	and	CCONJ
ajst-6290	8	15	producing	produce	VERB
ajst-6290	8	16	clean	clean	ADJ
ajst-6290	8	17	energy	energy	NOUN
ajst-6290	8	18	.	.	PUNCT
ajst-6290	9	1	in	in	ADP
ajst-6290	9	2	addition	addition	NOUN
ajst-6290	9	3	,	,	PUNCT
ajst-6290	9	4	the	the	DET
ajst-6290	9	5	development	development	NOUN
ajst-6290	9	6	of	of	ADP
ajst-6290	9	7	synthetic	synthetic	ADJ
ajst-6290	9	8	biology	biology	NOUN
ajst-6290	9	9	also	also	ADV
ajst-6290	9	10	involves	involve	VERB
ajst-6290	9	11	artificial	artificial	ADJ
ajst-6290	9	12	intelligence	intelligence	NOUN
ajst-6290	9	13	and	and	CCONJ
ajst-6290	9	14	machine	machine	NOUN
ajst-6290	9	15	learning	learning	NOUN
ajst-6290	9	16	,	,	PUNCT
ajst-6290	9	17	which	which	PRON
ajst-6290	9	18	can	can	AUX
ajst-6290	9	19	help	help	VERB
ajst-6290	9	20	accelerate	accelerate	VERB
ajst-6290	9	21	the	the	DET
ajst-6290	9	22	design	design	NOUN
ajst-6290	9	23	and	and	CCONJ
ajst-6290	9	24	construction	construction	NOUN
ajst-6290	9	25	of	of	ADP
ajst-6290	9	26	biological	biological	ADJ
ajst-6290	9	27	systems	system	NOUN
ajst-6290	9	28	,	,	PUNCT
ajst-6290	9	29	thus	thus	ADV
ajst-6290	9	30	speeding	speed	VERB
ajst-6290	9	31	up	up	ADP
ajst-6290	9	32	the	the	DET
ajst-6290	9	33	progress	progress	NOUN
ajst-6290	9	34	of	of	ADP
ajst-6290	9	35	synthetic	synthetic	ADJ
ajst-6290	9	36	biology	biology	NOUN
ajst-6290	9	37	.	.	PUNCT
ajst-6290	10	1	although	although	SCONJ
ajst-6290	10	2	synthetic	synthetic	ADJ
ajst-6290	10	3	biology	biology	NOUN
ajst-6290	10	4	still	still	ADV
ajst-6290	10	5	faces	face	VERB
ajst-6290	10	6	many	many	ADJ
ajst-6290	10	7	challenges	challenge	NOUN
ajst-6290	10	8	,	,	PUNCT
ajst-6290	10	9	the	the	DET
ajst-6290	10	10	development	development	NOUN
ajst-6290	10	11	prospects	prospect	NOUN
ajst-6290	10	12	of	of	ADP
ajst-6290	10	13	this	this	DET
ajst-6290	10	14	field	field	NOUN
ajst-6290	10	15	are	be	AUX
ajst-6290	10	16	still	still	ADV
ajst-6290	10	17	very	very	ADV
ajst-6290	10	18	promising	promising	ADJ
ajst-6290	10	19	with	with	ADP
ajst-6290	10	20	the	the	DET
ajst-6290	10	21	continuous	continuous	ADJ
ajst-6290	10	22	advancement	advancement	NOUN
ajst-6290	10	23	of	of	ADP
ajst-6290	10	24	technology	technology	NOUN
ajst-6290	10	25	.	.	PUNCT
ajst-6290	11	1	this	this	DET
ajst-6290	11	2	article	article	NOUN
ajst-6290	11	3	aims	aim	VERB
ajst-6290	11	4	to	to	PART
ajst-6290	11	5	provide	provide	VERB
ajst-6290	11	6	an	an	DET
ajst-6290	11	7	overview	overview	NOUN
ajst-6290	11	8	of	of	ADP
ajst-6290	11	9	the	the	DET
ajst-6290	11	10	development	development	NOUN
ajst-6290	11	11	of	of	ADP
ajst-6290	11	12	synthetic	synthetic	ADJ
ajst-6290	11	13	biology	biology	NOUN
ajst-6290	11	14	,	,	PUNCT
ajst-6290	11	15	including	include	VERB
ajst-6290	11	16	its	its	PRON
ajst-6290	11	17	historical	historical	ADJ
ajst-6290	11	18	background	background	NOUN
ajst-6290	11	19	,	,	PUNCT
ajst-6290	11	20	early	early	ADJ
ajst-6290	11	21	development	development	NOUN
ajst-6290	11	22	,	,	PUNCT
ajst-6290	11	23	technological	technological	ADJ
ajst-6290	11	24	advances	advance	NOUN
ajst-6290	11	25	,	,	PUNCT
ajst-6290	11	26	applications	application	NOUN
ajst-6290	11	27	,	,	PUNCT
ajst-6290	11	28	ethical	ethical	ADJ
ajst-6290	11	29	and	and	CCONJ
ajst-6290	11	30	social	social	ADJ
ajst-6290	11	31	impacts	impact	NOUN
ajst-6290	11	32	,	,	PUNCT
ajst-6290	11	33	and	and	CCONJ
ajst-6290	11	34	future	future	ADJ
ajst-6290	11	35	directions	direction	NOUN
ajst-6290	11	36	,	,	PUNCT
ajst-6290	11	37	and	and	CCONJ
ajst-6290	11	38	explore	explore	VERB
ajst-6290	11	39	the	the	DET
ajst-6290	11	40	development	development	NOUN
ajst-6290	11	41	process	process	NOUN
ajst-6290	11	42	of	of	ADP
ajst-6290	11	43	synthetic	synthetic	ADJ
ajst-6290	11	44	biology	biology	NOUN
ajst-6290	11	45	over	over	ADP
ajst-6290	11	46	the	the	DET
ajst-6290	11	47	past	past	ADJ
ajst-6290	11	48	60	60	NUM
ajst-6290	11	49	years	year	NOUN
ajst-6290	11	50	.	.	PUNCT
ajst-6290	12	1	keywords	keyword	NOUN
ajst-6290	12	2	:	:	PUNCT
ajst-6290	12	3	synthetic	synthetic	ADJ
ajst-6290	12	4	biology	biology	NOUN
ajst-6290	12	5	,	,	PUNCT
ajst-6290	12	6	gene	gene	NOUN
ajst-6290	12	7	engineering	engineering	NOUN
ajst-6290	12	8	,	,	PUNCT
ajst-6290	12	9	recombinant	recombinant	ADJ
ajst-6290	12	10	dna	dna	NOUN
ajst-6290	12	11	.	.	PUNCT
ajst-6290	13	1	1	1	X
ajst-6290	13	2	.	.	X
ajst-6290	13	3	introduction	introduction	NOUN
ajst-6290	13	4	synthetic	synthetic	ADJ
ajst-6290	13	5	biology	biology	NOUN
ajst-6290	13	6	is	be	AUX
ajst-6290	13	7	a	a	DET
ajst-6290	13	8	promising	promising	ADJ
ajst-6290	13	9	interdisciplinary	interdisciplinary	ADJ
ajst-6290	13	10	discipline	discipline	NOUN
ajst-6290	13	11	that	that	PRON
ajst-6290	13	12	aims	aim	VERB
ajst-6290	13	13	to	to	PART
ajst-6290	13	14	integrate	integrate	VERB
ajst-6290	13	15	knowledge	knowledge	NOUN
ajst-6290	13	16	and	and	CCONJ
ajst-6290	13	17	technologies	technology	NOUN
ajst-6290	13	18	from	from	ADP
ajst-6290	13	19	different	different	ADJ
ajst-6290	13	20	fields	field	NOUN
ajst-6290	13	21	to	to	PART
ajst-6290	13	22	achieve	achieve	VERB
ajst-6290	13	23	precise	precise	ADJ
ajst-6290	13	24	control	control	NOUN
ajst-6290	13	25	and	and	CCONJ
ajst-6290	13	26	modification	modification	NOUN
ajst-6290	13	27	of	of	ADP
ajst-6290	13	28	living	living	NOUN
ajst-6290	13	29	systems	system	NOUN
ajst-6290	13	30	.	.	PUNCT
ajst-6290	14	1	it	it	PRON
ajst-6290	14	2	combines	combine	VERB
ajst-6290	14	3	theories	theory	NOUN
ajst-6290	14	4	and	and	CCONJ
ajst-6290	14	5	methods	method	NOUN
ajst-6290	14	6	from	from	ADP
ajst-6290	14	7	multiple	multiple	ADJ
ajst-6290	14	8	disciplines	discipline	NOUN
ajst-6290	14	9	,	,	PUNCT
ajst-6290	14	10	including	include	VERB
ajst-6290	14	11	engineering	engineering	NOUN
ajst-6290	14	12	,	,	PUNCT
ajst-6290	14	13	physics	physics	NOUN
ajst-6290	14	14	,	,	PUNCT
ajst-6290	14	15	chemistry	chemistry	NOUN
ajst-6290	14	16	and	and	CCONJ
ajst-6290	14	17	biology	biology	NOUN
ajst-6290	14	18	,	,	PUNCT
ajst-6290	14	19	with	with	ADP
ajst-6290	14	20	the	the	DET
ajst-6290	14	21	aim	aim	NOUN
ajst-6290	14	22	of	of	ADP
ajst-6290	14	23	building	build	VERB
ajst-6290	14	24	artificial	artificial	ADJ
ajst-6290	14	25	biological	biological	ADJ
ajst-6290	14	26	systems	system	NOUN
ajst-6290	14	27	to	to	PART
ajst-6290	14	28	address	address	VERB
ajst-6290	14	29	the	the	DET
ajst-6290	14	30	many	many	ADJ
ajst-6290	14	31	challenges	challenge	NOUN
ajst-6290	14	32	facing	face	VERB
ajst-6290	14	33	human	human	ADJ
ajst-6290	14	34	society	society	NOUN
ajst-6290	14	35	.	.	PUNCT
ajst-6290	15	1	over	over	ADP
ajst-6290	15	2	the	the	DET
ajst-6290	15	3	past	past	ADJ
ajst-6290	15	4	few	few	ADJ
ajst-6290	15	5	decades	decade	NOUN
ajst-6290	15	6	,	,	PUNCT
ajst-6290	15	7	the	the	DET
ajst-6290	15	8	rapid	rapid	ADJ
ajst-6290	15	9	development	development	NOUN
ajst-6290	15	10	of	of	ADP
ajst-6290	15	11	synthetic	synthetic	ADJ
ajst-6290	15	12	biology	biology	NOUN
ajst-6290	15	13	has	have	AUX
ajst-6290	15	14	advanced	advance	VERB
ajst-6290	15	15	human	human	ADJ
ajst-6290	15	16	understanding	understanding	NOUN
ajst-6290	15	17	of	of	ADP
ajst-6290	15	18	the	the	DET
ajst-6290	15	19	nature	nature	NOUN
ajst-6290	15	20	of	of	ADP
ajst-6290	15	21	life	life	NOUN
ajst-6290	15	22	and	and	CCONJ
ajst-6290	15	23	opened	open	VERB
ajst-6290	15	24	up	up	ADP
ajst-6290	15	25	many	many	ADJ
ajst-6290	15	26	new	new	ADJ
ajst-6290	15	27	possibilities	possibility	NOUN
ajst-6290	15	28	in	in	ADP
ajst-6290	15	29	areas	area	NOUN
ajst-6290	15	30	such	such	ADJ
ajst-6290	15	31	as	as	ADP
ajst-6290	15	32	biotechnology	biotechnology	NOUN
ajst-6290	15	33	,	,	PUNCT
ajst-6290	15	34	healthcare	healthcare	NOUN
ajst-6290	15	35	and	and	CCONJ
ajst-6290	15	36	environmental	environmental	ADJ
ajst-6290	15	37	protection	protection	NOUN
ajst-6290	15	38	.	.	PUNCT
ajst-6290	16	1	using	use	VERB
ajst-6290	16	2	engineering	engineering	NOUN
ajst-6290	16	3	ideas	idea	NOUN
ajst-6290	16	4	and	and	CCONJ
ajst-6290	16	5	methods	method	NOUN
ajst-6290	16	6	,	,	PUNCT
ajst-6290	16	7	synthetic	synthetic	ADJ
ajst-6290	16	8	biology	biology	NOUN
ajst-6290	16	9	is	be	AUX
ajst-6290	16	10	dedicated	dedicate	VERB
ajst-6290	16	11	to	to	ADP
ajst-6290	16	12	the	the	DET
ajst-6290	16	13	development	development	NOUN
ajst-6290	16	14	of	of	ADP
ajst-6290	16	15	entirely	entirely	ADV
ajst-6290	16	16	new	new	ADJ
ajst-6290	16	17	biological	biological	ADJ
ajst-6290	16	18	systems	system	NOUN
ajst-6290	16	19	in	in	ADP
ajst-6290	16	20	which	which	PRON
ajst-6290	16	21	specific	specific	ADJ
ajst-6290	16	22	biological	biological	ADJ
ajst-6290	16	23	functions	function	NOUN
ajst-6290	16	24	are	be	AUX
ajst-6290	16	25	integrated	integrate	VERB
ajst-6290	16	26	for	for	ADP
ajst-6290	16	27	a	a	DET
ajst-6290	16	28	variety	variety	NOUN
ajst-6290	16	29	of	of	ADP
ajst-6290	16	30	applications	application	NOUN
ajst-6290	16	31	.	.	PUNCT
ajst-6290	17	1	research	research	NOUN
ajst-6290	17	2	in	in	ADP
ajst-6290	17	3	synthetic	synthetic	ADJ
ajst-6290	17	4	biology	biology	NOUN
ajst-6290	17	5	covers	cover	VERB
ajst-6290	17	6	different	different	ADJ
ajst-6290	17	7	levels	level	NOUN
ajst-6290	17	8	from	from	ADP
ajst-6290	17	9	individual	individual	ADJ
ajst-6290	17	10	cells	cell	NOUN
ajst-6290	17	11	to	to	ADP
ajst-6290	17	12	whole	whole	ADJ
ajst-6290	17	13	ecosystems	ecosystem	NOUN
ajst-6290	17	14	,	,	PUNCT
ajst-6290	17	15	including	include	VERB
ajst-6290	17	16	gene	gene	NOUN
ajst-6290	17	17	regulation	regulation	NOUN
ajst-6290	17	18	,	,	PUNCT
ajst-6290	17	19	metabolic	metabolic	NOUN
ajst-6290	17	20	pathways	pathway	NOUN
ajst-6290	17	21	,	,	PUNCT
ajst-6290	17	22	signaling	signaling	ADJ
ajst-6290	17	23	,	,	PUNCT
ajst-6290	17	24	cellular	cellular	ADJ
ajst-6290	17	25	interactions	interaction	NOUN
ajst-6290	17	26	,	,	PUNCT
ajst-6290	17	27	ecological	ecological	ADJ
ajst-6290	17	28	adaptation	adaptation	NOUN
ajst-6290	17	29	,	,	PUNCT
ajst-6290	17	30	and	and	CCONJ
ajst-6290	17	31	many	many	ADJ
ajst-6290	17	32	other	other	ADJ
ajst-6290	17	33	aspects	aspect	NOUN
ajst-6290	17	34	.	.	PUNCT
ajst-6290	18	1	these	these	DET
ajst-6290	18	2	studies	study	NOUN
ajst-6290	18	3	are	be	AUX
ajst-6290	18	4	not	not	PART
ajst-6290	18	5	only	only	ADV
ajst-6290	18	6	important	important	ADJ
ajst-6290	18	7	for	for	ADP
ajst-6290	18	8	theoretical	theoretical	ADJ
ajst-6290	18	9	research	research	NOUN
ajst-6290	18	10	,	,	PUNCT
ajst-6290	18	11	but	but	CCONJ
ajst-6290	18	12	also	also	ADV
ajst-6290	18	13	provide	provide	VERB
ajst-6290	18	14	new	new	ADJ
ajst-6290	18	15	opportunities	opportunity	NOUN
ajst-6290	18	16	and	and	CCONJ
ajst-6290	18	17	challenges	challenge	NOUN
ajst-6290	18	18	in	in	ADP
ajst-6290	18	19	the	the	DET
ajst-6290	18	20	fields	field	NOUN
ajst-6290	18	21	of	of	ADP
ajst-6290	18	22	biopharmaceuticals	biopharmaceutical	NOUN
ajst-6290	18	23	,	,	PUNCT
ajst-6290	18	24	industrial	industrial	ADJ
ajst-6290	18	25	production	production	NOUN
ajst-6290	18	26	,	,	PUNCT
ajst-6290	18	27	and	and	CCONJ
ajst-6290	18	28	environmental	environmental	ADJ
ajst-6290	18	29	management	management	NOUN
ajst-6290	18	30	.	.	PUNCT
ajst-6290	19	1	the	the	DET
ajst-6290	19	2	purpose	purpose	NOUN
ajst-6290	19	3	of	of	ADP
ajst-6290	19	4	this	this	DET
ajst-6290	19	5	paper	paper	NOUN
ajst-6290	19	6	is	be	AUX
ajst-6290	19	7	to	to	PART
ajst-6290	19	8	outline	outline	VERB
ajst-6290	19	9	the	the	DET
ajst-6290	19	10	development	development	NOUN
ajst-6290	19	11	of	of	ADP
ajst-6290	19	12	synthetic	synthetic	ADJ
ajst-6290	19	13	biology	biology	NOUN
ajst-6290	19	14	,	,	PUNCT
ajst-6290	19	15	including	include	VERB
ajst-6290	19	16	its	its	PRON
ajst-6290	19	17	historical	historical	ADJ
ajst-6290	19	18	background	background	NOUN
ajst-6290	19	19	,	,	PUNCT
ajst-6290	19	20	early	early	ADJ
ajst-6290	19	21	development	development	NOUN
ajst-6290	19	22	,	,	PUNCT
ajst-6290	19	23	technological	technological	ADJ
ajst-6290	19	24	advances	advance	NOUN
ajst-6290	19	25	,	,	PUNCT
ajst-6290	19	26	applications	application	NOUN
ajst-6290	19	27	,	,	PUNCT
ajst-6290	19	28	ethical	ethical	ADJ
ajst-6290	19	29	and	and	CCONJ
ajst-6290	19	30	social	social	ADJ
ajst-6290	19	31	implications	implication	NOUN
ajst-6290	19	32	,	,	PUNCT
ajst-6290	19	33	and	and	CCONJ
ajst-6290	19	34	future	future	ADJ
ajst-6290	19	35	directions	direction	NOUN
ajst-6290	19	36	,	,	PUNCT
ajst-6290	19	37	and	and	CCONJ
ajst-6290	19	38	to	to	PART
ajst-6290	19	39	explore	explore	VERB
ajst-6290	19	40	the	the	DET
ajst-6290	19	41	development	development	NOUN
ajst-6290	19	42	of	of	ADP
ajst-6290	19	43	synthetic	synthetic	ADJ
ajst-6290	19	44	biology	biology	NOUN
ajst-6290	19	45	in	in	ADP
ajst-6290	19	46	the	the	DET
ajst-6290	19	47	past	past	ADJ
ajst-6290	19	48	60	60	NUM
ajst-6290	19	49	years	year	NOUN
ajst-6290	19	50	.	.	PUNCT
ajst-6290	20	1	2	2	X
ajst-6290	20	2	.	.	X
ajst-6290	20	3	early	early	ADJ
ajst-6290	20	4	synthetic	synthetic	ADJ
ajst-6290	20	5	biology	biology	NOUN
ajst-6290	20	6	(	(	PUNCT
ajst-6290	20	7	1960s1990s	1960s1990s	NUM
ajst-6290	20	8	)	)	PUNCT
ajst-6290	20	9	2.1	2.1	NUM
ajst-6290	20	10	.	.	PUNCT
ajst-6290	21	1	origins	origin	NOUN
ajst-6290	21	2	of	of	ADP
ajst-6290	21	3	gene	gene	NOUN
ajst-6290	21	4	synthesis	synthesis	NOUN
ajst-6290	21	5	and	and	CCONJ
ajst-6290	21	6	genetic	genetic	ADJ
ajst-6290	21	7	engineering	engineering	NOUN
ajst-6290	21	8	the	the	DET
ajst-6290	21	9	origins	origin	NOUN
ajst-6290	21	10	of	of	ADP
ajst-6290	21	11	gene	gene	NOUN
ajst-6290	21	12	synthesis	synthesis	NOUN
ajst-6290	21	13	and	and	CCONJ
ajst-6290	21	14	genetic	genetic	ADJ
ajst-6290	21	15	engineering	engineering	NOUN
ajst-6290	21	16	became	become	VERB
ajst-6290	21	17	a	a	DET
ajst-6290	21	18	key	key	ADJ
ajst-6290	21	19	period	period	NOUN
ajst-6290	21	20	in	in	ADP
ajst-6290	21	21	synthetic	synthetic	ADJ
ajst-6290	21	22	biology	biology	NOUN
ajst-6290	21	23	research	research	NOUN
ajst-6290	21	24	from	from	ADP
ajst-6290	21	25	the	the	DET
ajst-6290	21	26	1960s	1960	NOUN
ajst-6290	21	27	to	to	ADP
ajst-6290	21	28	the	the	DET
ajst-6290	21	29	1970s	1970	NOUN
ajst-6290	21	30	.	.	PUNCT
ajst-6290	22	1	in	in	ADP
ajst-6290	22	2	1972	1972	NUM
ajst-6290	22	3	,	,	PUNCT
ajst-6290	22	4	paul	paul	PROPN
ajst-6290	22	5	berg	berg	PROPN
ajst-6290	22	6	and	and	CCONJ
ajst-6290	22	7	stanley	stanley	PROPN
ajst-6290	22	8	cohen	cohen	PROPN
ajst-6290	22	9	and	and	CCONJ
ajst-6290	22	10	others	other	NOUN
ajst-6290	22	11	successfully	successfully	ADV
ajst-6290	22	12	constructed	construct	VERB
ajst-6290	22	13	the	the	DET
ajst-6290	22	14	first	first	ADJ
ajst-6290	22	15	generation	generation	NOUN
ajst-6290	22	16	of	of	ADP
ajst-6290	22	17	genetically	genetically	ADV
ajst-6290	22	18	engineered	engineer	VERB
ajst-6290	22	19	bacteria	bacteria	NOUN
ajst-6290	22	20	by	by	ADP
ajst-6290	22	21	inserting	insert	VERB
ajst-6290	22	22	exogenous	exogenous	ADJ
ajst-6290	22	23	dna	dna	NOUN
ajst-6290	22	24	into	into	ADP
ajst-6290	22	25	the	the	DET
ajst-6290	22	26	chromosomes	chromosome	NOUN
ajst-6290	22	27	of	of	ADP
ajst-6290	22	28	bacteria	bacteria	NOUN
ajst-6290	22	29	[	[	X
ajst-6290	22	30	1	1	NUM
ajst-6290	22	31	]	]	PUNCT
ajst-6290	22	32	.	.	PUNCT
ajst-6290	23	1	this	this	DET
ajst-6290	23	2	landmark	landmark	NOUN
ajst-6290	23	3	experiment	experiment	NOUN
ajst-6290	23	4	not	not	PART
ajst-6290	23	5	only	only	ADV
ajst-6290	23	6	pioneered	pioneer	VERB
ajst-6290	23	7	synthetic	synthetic	ADJ
ajst-6290	23	8	biology	biology	NOUN
ajst-6290	23	9	,	,	PUNCT
ajst-6290	23	10	but	but	CCONJ
ajst-6290	23	11	also	also	ADV
ajst-6290	23	12	revolutionized	revolutionize	VERB
ajst-6290	23	13	the	the	DET
ajst-6290	23	14	field	field	NOUN
ajst-6290	23	15	of	of	ADP
ajst-6290	23	16	genetic	genetic	ADJ
ajst-6290	23	17	engineering	engineering	NOUN
ajst-6290	23	18	.	.	PUNCT
ajst-6290	24	1	the	the	DET
ajst-6290	24	2	development	development	NOUN
ajst-6290	24	3	of	of	ADP
ajst-6290	24	4	gene	gene	NOUN
ajst-6290	24	5	synthesis	synthesis	NOUN
ajst-6290	24	6	and	and	CCONJ
ajst-6290	24	7	genetic	genetic	ADJ
ajst-6290	24	8	engineering	engineering	NOUN
ajst-6290	24	9	has	have	AUX
ajst-6290	24	10	enabled	enable	VERB
ajst-6290	24	11	the	the	DET
ajst-6290	24	12	redesign	redesign	NOUN
ajst-6290	24	13	,	,	PUNCT
ajst-6290	24	14	construction	construction	NOUN
ajst-6290	24	15	and	and	CCONJ
ajst-6290	24	16	modification	modification	NOUN
ajst-6290	24	17	of	of	ADP
ajst-6290	24	18	the	the	DET
ajst-6290	24	19	genetic	genetic	ADJ
ajst-6290	24	20	information	information	NOUN
ajst-6290	24	21	of	of	ADP
ajst-6290	24	22	organisms	organism	NOUN
ajst-6290	24	23	at	at	ADP
ajst-6290	24	24	the	the	DET
ajst-6290	24	25	molecular	molecular	ADJ
ajst-6290	24	26	level	level	NOUN
ajst-6290	24	27	,	,	PUNCT
ajst-6290	24	28	thus	thus	ADV
ajst-6290	24	29	opening	open	VERB
ajst-6290	24	30	up	up	ADP
ajst-6290	24	31	the	the	DET
ajst-6290	24	32	possibility	possibility	NOUN
ajst-6290	24	33	of	of	ADP
ajst-6290	24	34	synthetic	synthetic	ADJ
ajst-6290	24	35	life	life	NOUN
ajst-6290	24	36	.	.	PUNCT
ajst-6290	25	1	this	this	PRON
ajst-6290	25	2	also	also	ADV
ajst-6290	25	3	provides	provide	VERB
ajst-6290	25	4	tremendous	tremendous	ADJ
ajst-6290	25	5	opportunities	opportunity	NOUN
ajst-6290	25	6	and	and	CCONJ
ajst-6290	25	7	challenges	challenge	NOUN
ajst-6290	25	8	for	for	ADP
ajst-6290	25	9	the	the	DET
ajst-6290	25	10	development	development	NOUN
ajst-6290	25	11	of	of	ADP
ajst-6290	25	12	the	the	DET
ajst-6290	25	13	fields	field	NOUN
ajst-6290	25	14	of	of	ADP
ajst-6290	25	15	biotechnology	biotechnology	NOUN
ajst-6290	25	16	,	,	PUNCT
ajst-6290	25	17	medicine	medicine	NOUN
ajst-6290	25	18	and	and	CCONJ
ajst-6290	25	19	agriculture	agriculture	NOUN
ajst-6290	25	20	.	.	PUNCT
ajst-6290	26	1	2.2	2.2	NUM
ajst-6290	26	2	.	.	PUNCT
ajst-6290	27	1	the	the	DET
ajst-6290	27	2	main	main	ADJ
ajst-6290	27	3	research	research	NOUN
ajst-6290	27	4	directions	direction	NOUN
ajst-6290	27	5	of	of	ADP
ajst-6290	27	6	synthetic	synthetic	ADJ
ajst-6290	27	7	biology	biology	NOUN
ajst-6290	27	8	in	in	ADP
ajst-6290	27	9	the	the	DET
ajst-6290	27	10	early	early	ADJ
ajst-6290	27	11	period	period	NOUN
ajst-6290	27	12	from	from	ADP
ajst-6290	27	13	the	the	DET
ajst-6290	27	14	1970s	1970	NOUN
ajst-6290	27	15	to	to	ADP
ajst-6290	27	16	the	the	DET
ajst-6290	27	17	1980s	1980	NOUN
ajst-6290	27	18	,	,	PUNCT
ajst-6290	27	19	the	the	DET
ajst-6290	27	20	research	research	NOUN
ajst-6290	27	21	directions	direction	NOUN
ajst-6290	27	22	of	of	ADP
ajst-6290	27	23	synthetic	synthetic	ADJ
ajst-6290	27	24	biology	biology	NOUN
ajst-6290	27	25	were	be	AUX
ajst-6290	27	26	mainly	mainly	ADV
ajst-6290	27	27	focused	focus	VERB
ajst-6290	27	28	on	on	ADP
ajst-6290	27	29	the	the	DET
ajst-6290	27	30	following	follow	VERB
ajst-6290	27	31	areas	area	NOUN
ajst-6290	27	32	.	.	PUNCT
ajst-6290	28	1	2.2.1	2.2.1	NUM
ajst-6290	28	2	.	.	PUNCT
ajst-6290	29	1	the	the	DET
ajst-6290	29	2	development	development	NOUN
ajst-6290	29	3	and	and	CCONJ
ajst-6290	29	4	application	application	NOUN
ajst-6290	29	5	of	of	ADP
ajst-6290	29	6	recombinant	recombinant	ADJ
ajst-6290	29	7	dna	dna	PROPN
ajst-6290	29	8	technology	technology	NOUN
ajst-6290	29	9	recombinant	recombinant	ADJ
ajst-6290	29	10	dna	dna	NOUN
ajst-6290	29	11	technology	technology	NOUN
ajst-6290	29	12	(	(	PUNCT
ajst-6290	29	13	rdna	rdna	NOUN
ajst-6290	29	14	technology	technology	NOUN
ajst-6290	29	15	)	)	PUNCT
ajst-6290	29	16	is	be	AUX
ajst-6290	29	17	one	one	NUM
ajst-6290	29	18	of	of	ADP
ajst-6290	29	19	the	the	DET
ajst-6290	29	20	core	core	NOUN
ajst-6290	29	21	technologies	technology	NOUN
ajst-6290	29	22	of	of	ADP
ajst-6290	29	23	synthetic	synthetic	ADJ
ajst-6290	29	24	biology	biology	NOUN
ajst-6290	29	25	.	.	PUNCT
ajst-6290	30	1	by	by	ADP
ajst-6290	30	2	performing	perform	VERB
ajst-6290	30	3	operations	operation	NOUN
ajst-6290	30	4	such	such	ADJ
ajst-6290	30	5	as	as	ADP
ajst-6290	30	6	shearing	shearing	NOUN
ajst-6290	30	7	,	,	PUNCT
ajst-6290	30	8	ligation	ligation	NOUN
ajst-6290	30	9	and	and	CCONJ
ajst-6290	30	10	transfer	transfer	NOUN
ajst-6290	30	11	of	of	ADP
ajst-6290	30	12	dna	dna	PROPN
ajst-6290	30	13	sequences	sequence	NOUN
ajst-6290	30	14	,	,	PUNCT
ajst-6290	30	15	researchers	researcher	NOUN
ajst-6290	30	16	can	can	AUX
ajst-6290	30	17	construct	construct	VERB
ajst-6290	30	18	new	new	ADJ
ajst-6290	30	19	dna	dna	PROPN
ajst-6290	30	20	molecules	molecule	NOUN
ajst-6290	30	21	and	and	CCONJ
ajst-6290	30	22	96	96	NUM
ajst-6290	30	23	insert	insert	VERB
ajst-6290	30	24	them	they	PRON
ajst-6290	30	25	into	into	ADP
ajst-6290	30	26	cells	cell	NOUN
ajst-6290	30	27	.	.	PUNCT
ajst-6290	31	1	the	the	DET
ajst-6290	31	2	advent	advent	NOUN
ajst-6290	31	3	of	of	ADP
ajst-6290	31	4	this	this	DET
ajst-6290	31	5	technology	technology	NOUN
ajst-6290	31	6	has	have	AUX
ajst-6290	31	7	provided	provide	VERB
ajst-6290	31	8	a	a	DET
ajst-6290	31	9	solid	solid	ADJ
ajst-6290	31	10	foundation	foundation	NOUN
ajst-6290	31	11	for	for	ADP
ajst-6290	31	12	fields	field	NOUN
ajst-6290	31	13	such	such	ADJ
ajst-6290	31	14	as	as	ADP
ajst-6290	31	15	genetic	genetic	ADJ
ajst-6290	31	16	engineering	engineering	NOUN
ajst-6290	31	17	and	and	CCONJ
ajst-6290	31	18	gene	gene	NOUN
ajst-6290	31	19	therapy	therapy	NOUN
ajst-6290	31	20	[	[	X
ajst-6290	31	21	2	2	NUM
ajst-6290	31	22	]	]	PUNCT
ajst-6290	31	23	.	.	PUNCT
ajst-6290	32	1	2.2.2	2.2.2	X
ajst-6290	32	2	.	.	PUNCT
ajst-6290	33	1	experiments	experiment	NOUN
ajst-6290	33	2	for	for	ADP
ajst-6290	33	3	the	the	DET
ajst-6290	33	4	synthesis	synthesis	NOUN
ajst-6290	33	5	of	of	ADP
ajst-6290	33	6	peptides	peptide	NOUN
ajst-6290	33	7	and	and	CCONJ
ajst-6290	33	8	proteins	protein	NOUN
ajst-6290	33	9	experiments	experiment	NOUN
ajst-6290	33	10	for	for	ADP
ajst-6290	33	11	synthesizing	synthesize	VERB
ajst-6290	33	12	peptides	peptide	NOUN
ajst-6290	33	13	and	and	CCONJ
ajst-6290	33	14	proteins	protein	NOUN
ajst-6290	33	15	were	be	AUX
ajst-6290	33	16	also	also	ADV
ajst-6290	33	17	one	one	NUM
ajst-6290	33	18	of	of	ADP
ajst-6290	33	19	the	the	DET
ajst-6290	33	20	important	important	ADJ
ajst-6290	33	21	research	research	NOUN
ajst-6290	33	22	directions	direction	NOUN
ajst-6290	33	23	of	of	ADP
ajst-6290	33	24	early	early	ADJ
ajst-6290	33	25	synthetic	synthetic	ADJ
ajst-6290	33	26	biology	biology	NOUN
ajst-6290	33	27	.	.	PUNCT
ajst-6290	34	1	scientists	scientist	NOUN
ajst-6290	34	2	constructed	construct	VERB
ajst-6290	34	3	peptides	peptide	NOUN
ajst-6290	34	4	and	and	CCONJ
ajst-6290	34	5	proteins	protein	NOUN
ajst-6290	34	6	by	by	ADP
ajst-6290	34	7	chemical	chemical	ADJ
ajst-6290	34	8	synthesis	synthesis	NOUN
ajst-6290	34	9	and	and	CCONJ
ajst-6290	34	10	used	use	VERB
ajst-6290	34	11	them	they	PRON
ajst-6290	34	12	in	in	ADP
ajst-6290	34	13	fields	field	NOUN
ajst-6290	34	14	such	such	ADJ
ajst-6290	34	15	as	as	ADP
ajst-6290	34	16	drug	drug	NOUN
ajst-6290	34	17	development	development	NOUN
ajst-6290	34	18	and	and	CCONJ
ajst-6290	34	19	biological	biological	ADJ
ajst-6290	34	20	research	research	NOUN
ajst-6290	34	21	.	.	PUNCT
ajst-6290	35	1	their	their	PRON
ajst-6290	35	2	development	development	NOUN
ajst-6290	35	3	has	have	AUX
ajst-6290	35	4	provided	provide	VERB
ajst-6290	35	5	new	new	ADJ
ajst-6290	35	6	avenues	avenue	NOUN
ajst-6290	35	7	for	for	ADP
ajst-6290	35	8	biopharmaceuticals	biopharmaceutical	NOUN
ajst-6290	35	9	and	and	CCONJ
ajst-6290	35	10	new	new	ADJ
ajst-6290	35	11	means	mean	NOUN
ajst-6290	35	12	for	for	SCONJ
ajst-6290	35	13	researchers	researcher	NOUN
ajst-6290	35	14	to	to	PART
ajst-6290	35	15	probe	probe	VERB
ajst-6290	35	16	deeply	deeply	ADV
ajst-6290	35	17	into	into	ADP
ajst-6290	35	18	the	the	DET
ajst-6290	35	19	structure	structure	NOUN
ajst-6290	35	20	and	and	CCONJ
ajst-6290	35	21	function	function	NOUN
ajst-6290	35	22	of	of	ADP
ajst-6290	35	23	proteins	protein	NOUN
ajst-6290	35	24	[	[	X
ajst-6290	35	25	3	3	NUM
ajst-6290	35	26	]	]	PUNCT
ajst-6290	35	27	.	.	PUNCT
ajst-6290	36	1	2.2.3	2.2.3	X
ajst-6290	36	2	.	.	PUNCT
ajst-6290	37	1	research	research	NOUN
ajst-6290	37	2	on	on	ADP
ajst-6290	37	3	gene	gene	NOUN
ajst-6290	37	4	regulation	regulation	NOUN
ajst-6290	37	5	and	and	CCONJ
ajst-6290	37	6	signal	signal	ADJ
ajst-6290	37	7	transduction	transduction	NOUN
ajst-6290	37	8	gene	gene	NOUN
ajst-6290	37	9	regulation	regulation	NOUN
ajst-6290	37	10	and	and	CCONJ
ajst-6290	37	11	signal	signal	ADJ
ajst-6290	37	12	transduction	transduction	NOUN
ajst-6290	37	13	is	be	AUX
ajst-6290	37	14	another	another	DET
ajst-6290	37	15	important	important	ADJ
ajst-6290	37	16	direction	direction	NOUN
ajst-6290	37	17	of	of	ADP
ajst-6290	37	18	synthetic	synthetic	ADJ
ajst-6290	37	19	biology	biology	NOUN
ajst-6290	37	20	research	research	NOUN
ajst-6290	37	21	.	.	PUNCT
ajst-6290	38	1	through	through	ADP
ajst-6290	38	2	the	the	DET
ajst-6290	38	3	study	study	NOUN
ajst-6290	38	4	of	of	ADP
ajst-6290	38	5	gene	gene	NOUN
ajst-6290	38	6	regulatory	regulatory	ADJ
ajst-6290	38	7	networks	network	NOUN
ajst-6290	38	8	and	and	CCONJ
ajst-6290	38	9	signaling	signal	VERB
ajst-6290	38	10	pathways	pathway	NOUN
ajst-6290	38	11	,	,	PUNCT
ajst-6290	38	12	researchers	researcher	NOUN
ajst-6290	38	13	have	have	AUX
ajst-6290	38	14	gained	gain	VERB
ajst-6290	38	15	insight	insight	NOUN
ajst-6290	38	16	into	into	ADP
ajst-6290	38	17	the	the	DET
ajst-6290	38	18	nature	nature	NOUN
ajst-6290	38	19	and	and	CCONJ
ajst-6290	38	20	laws	law	NOUN
ajst-6290	38	21	of	of	ADP
ajst-6290	38	22	living	living	NOUN
ajst-6290	38	23	systems	system	NOUN
ajst-6290	38	24	and	and	CCONJ
ajst-6290	38	25	provided	provide	VERB
ajst-6290	38	26	new	new	ADJ
ajst-6290	38	27	ways	way	NOUN
ajst-6290	38	28	to	to	PART
ajst-6290	38	29	control	control	VERB
ajst-6290	38	30	and	and	CCONJ
ajst-6290	38	31	exploit	exploit	VERB
ajst-6290	38	32	the	the	DET
ajst-6290	38	33	phenomenon	phenomenon	NOUN
ajst-6290	38	34	of	of	ADP
ajst-6290	38	35	life	life	NOUN
ajst-6290	38	36	[	[	X
ajst-6290	38	37	4	4	NUM
ajst-6290	38	38	]	]	PUNCT
ajst-6290	38	39	.	.	PUNCT
ajst-6290	39	1	2.3	2.3	NUM
ajst-6290	39	2	.	.	PUNCT
ajst-6290	40	1	key	key	ADJ
ajst-6290	40	2	figures	figure	NOUN
ajst-6290	40	3	of	of	ADP
ajst-6290	40	4	early	early	ADJ
ajst-6290	40	5	synthetic	synthetic	ADJ
ajst-6290	40	6	biology	biology	NOUN
ajst-6290	40	7	and	and	CCONJ
ajst-6290	40	8	their	their	PRON
ajst-6290	40	9	contributions	contribution	NOUN
ajst-6290	40	10	in	in	ADP
ajst-6290	40	11	the	the	DET
ajst-6290	40	12	development	development	NOUN
ajst-6290	40	13	of	of	ADP
ajst-6290	40	14	early	early	ADJ
ajst-6290	40	15	synthetic	synthetic	ADJ
ajst-6290	40	16	biology	biology	NOUN
ajst-6290	40	17	,	,	PUNCT
ajst-6290	40	18	paul	paul	PROPN
ajst-6290	40	19	berg	berg	PROPN
ajst-6290	40	20	,	,	PUNCT
ajst-6290	40	21	herbert	herbert	PROPN
ajst-6290	40	22	boyer	boyer	PROPN
ajst-6290	40	23	and	and	CCONJ
ajst-6290	40	24	stanley	stanley	PROPN
ajst-6290	40	25	cohen	cohen	PROPN
ajst-6290	40	26	were	be	AUX
ajst-6290	40	27	among	among	ADP
ajst-6290	40	28	the	the	DET
ajst-6290	40	29	key	key	ADJ
ajst-6290	40	30	figures	figure	NOUN
ajst-6290	40	31	whose	whose	DET
ajst-6290	40	32	contributions	contribution	NOUN
ajst-6290	40	33	laid	lay	VERB
ajst-6290	40	34	the	the	DET
ajst-6290	40	35	foundation	foundation	NOUN
ajst-6290	40	36	for	for	ADP
ajst-6290	40	37	the	the	DET
ajst-6290	40	38	rapid	rapid	ADJ
ajst-6290	40	39	development	development	NOUN
ajst-6290	40	40	of	of	ADP
ajst-6290	40	41	the	the	DET
ajst-6290	40	42	field	field	NOUN
ajst-6290	40	43	.	.	PUNCT
ajst-6290	41	1	2.3.1	2.3.1	X
ajst-6290	41	2	.	.	PUNCT
ajst-6290	42	1	paul	paul	PROPN
ajst-6290	42	2	berg	berg	PROPN
ajst-6290	42	3	paul	paul	PROPN
ajst-6290	42	4	berg	berg	PROPN
ajst-6290	42	5	is	be	AUX
ajst-6290	42	6	considered	consider	VERB
ajst-6290	42	7	to	to	PART
ajst-6290	42	8	be	be	AUX
ajst-6290	42	9	one	one	NUM
ajst-6290	42	10	of	of	ADP
ajst-6290	42	11	the	the	DET
ajst-6290	42	12	founding	found	VERB
ajst-6290	42	13	fathers	father	NOUN
ajst-6290	42	14	of	of	ADP
ajst-6290	42	15	synthetic	synthetic	ADJ
ajst-6290	42	16	biology	biology	NOUN
ajst-6290	42	17	.	.	PUNCT
ajst-6290	43	1	he	he	PRON
ajst-6290	43	2	was	be	AUX
ajst-6290	43	3	one	one	NUM
ajst-6290	43	4	of	of	ADP
ajst-6290	43	5	the	the	DET
ajst-6290	43	6	first	first	ADJ
ajst-6290	43	7	scientists	scientist	NOUN
ajst-6290	43	8	to	to	PART
ajst-6290	43	9	successfully	successfully	ADV
ajst-6290	43	10	implement	implement	VERB
ajst-6290	43	11	the	the	DET
ajst-6290	43	12	technique	technique	NOUN
ajst-6290	43	13	of	of	ADP
ajst-6290	43	14	dna	dna	PROPN
ajst-6290	43	15	recombination	recombination	NOUN
ajst-6290	43	16	,	,	PUNCT
ajst-6290	43	17	which	which	PRON
ajst-6290	43	18	laid	lay	VERB
ajst-6290	43	19	a	a	DET
ajst-6290	43	20	solid	solid	ADJ
ajst-6290	43	21	foundation	foundation	NOUN
ajst-6290	43	22	for	for	ADP
ajst-6290	43	23	the	the	DET
ajst-6290	43	24	development	development	NOUN
ajst-6290	43	25	of	of	ADP
ajst-6290	43	26	genetic	genetic	ADJ
ajst-6290	43	27	engineering	engineering	NOUN
ajst-6290	43	28	and	and	CCONJ
ajst-6290	43	29	synthetic	synthetic	ADJ
ajst-6290	43	30	biology	biology	NOUN
ajst-6290	43	31	.	.	PUNCT
ajst-6290	44	1	in	in	ADP
ajst-6290	44	2	the	the	DET
ajst-6290	44	3	1960s	1960	NOUN
ajst-6290	44	4	,	,	PUNCT
ajst-6290	44	5	berg	berg	PROPN
ajst-6290	44	6	used	use	VERB
ajst-6290	44	7	restriction	restriction	NOUN
ajst-6290	44	8	endonucleases	endonuclease	NOUN
ajst-6290	44	9	and	and	CCONJ
ajst-6290	44	10	dna	dna	NOUN
ajst-6290	44	11	ligases	ligase	NOUN
ajst-6290	44	12	to	to	PART
ajst-6290	44	13	create	create	VERB
ajst-6290	44	14	the	the	DET
ajst-6290	44	15	first	first	ADJ
ajst-6290	44	16	genetically	genetically	ADV
ajst-6290	44	17	recombinant	recombinant	ADJ
ajst-6290	44	18	dna	dna	NOUN
ajst-6290	44	19	molecule	molecule	NOUN
ajst-6290	44	20	by	by	ADP
ajst-6290	44	21	joining	join	VERB
ajst-6290	44	22	two	two	NUM
ajst-6290	44	23	pieces	piece	NOUN
ajst-6290	44	24	of	of	ADP
ajst-6290	44	25	dna	dna	NOUN
ajst-6290	44	26	from	from	ADP
ajst-6290	44	27	different	different	ADJ
ajst-6290	44	28	sources	source	NOUN
ajst-6290	44	29	together	together	ADV
ajst-6290	45	1	[	[	X
ajst-6290	45	2	1	1	NUM
ajst-6290	45	3	]	]	PUNCT
ajst-6290	45	4	.	.	PUNCT
ajst-6290	46	1	this	this	DET
ajst-6290	46	2	achievement	achievement	NOUN
ajst-6290	46	3	allowed	allow	VERB
ajst-6290	46	4	the	the	DET
ajst-6290	46	5	creation	creation	NOUN
ajst-6290	46	6	of	of	ADP
ajst-6290	46	7	entirely	entirely	ADV
ajst-6290	46	8	new	new	ADJ
ajst-6290	46	9	genomes	genome	NOUN
ajst-6290	46	10	by	by	ADP
ajst-6290	46	11	combining	combine	VERB
ajst-6290	46	12	dna	dna	PROPN
ajst-6290	46	13	sequences	sequence	NOUN
ajst-6290	46	14	from	from	ADP
ajst-6290	46	15	different	different	ADJ
ajst-6290	46	16	species	specie	NOUN
ajst-6290	46	17	,	,	PUNCT
ajst-6290	46	18	thus	thus	ADV
ajst-6290	46	19	altering	alter	VERB
ajst-6290	46	20	the	the	DET
ajst-6290	46	21	genetic	genetic	ADJ
ajst-6290	46	22	characteristics	characteristic	NOUN
ajst-6290	46	23	of	of	ADP
ajst-6290	46	24	organisms	organism	NOUN
ajst-6290	46	25	.	.	PUNCT
ajst-6290	47	1	2.3.2	2.3.2	X
ajst-6290	47	2	.	.	PUNCT
ajst-6290	47	3	herbert	herbert	PROPN
ajst-6290	47	4	boyer	boyer	PROPN
ajst-6290	47	5	herbert	herbert	PROPN
ajst-6290	47	6	boyer	boyer	PROPN
ajst-6290	47	7	is	be	AUX
ajst-6290	47	8	another	another	DET
ajst-6290	47	9	one	one	NUM
ajst-6290	47	10	of	of	ADP
ajst-6290	47	11	the	the	DET
ajst-6290	47	12	important	important	ADJ
ajst-6290	47	13	founders	founder	NOUN
ajst-6290	47	14	of	of	ADP
ajst-6290	47	15	synthetic	synthetic	ADJ
ajst-6290	47	16	biology	biology	NOUN
ajst-6290	47	17	.	.	PUNCT
ajst-6290	48	1	together	together	ADV
ajst-6290	48	2	with	with	ADP
ajst-6290	48	3	stanley	stanley	PROPN
ajst-6290	48	4	cohen	cohen	PROPN
ajst-6290	48	5	,	,	PUNCT
ajst-6290	48	6	he	he	PRON
ajst-6290	48	7	worked	work	VERB
ajst-6290	48	8	on	on	ADP
ajst-6290	48	9	recombinant	recombinant	ADJ
ajst-6290	48	10	genetic	genetic	ADJ
ajst-6290	48	11	techniques	technique	NOUN
ajst-6290	48	12	and	and	CCONJ
ajst-6290	48	13	applied	apply	VERB
ajst-6290	48	14	this	this	DET
ajst-6290	48	15	technology	technology	NOUN
ajst-6290	48	16	to	to	ADP
ajst-6290	48	17	the	the	DET
ajst-6290	48	18	construction	construction	NOUN
ajst-6290	48	19	of	of	ADP
ajst-6290	48	20	biomolecules	biomolecule	NOUN
ajst-6290	48	21	with	with	ADP
ajst-6290	48	22	new	new	ADJ
ajst-6290	48	23	functions	function	NOUN
ajst-6290	48	24	.	.	PUNCT
ajst-6290	49	1	this	this	DET
ajst-6290	49	2	research	research	NOUN
ajst-6290	49	3	opened	open	VERB
ajst-6290	49	4	a	a	DET
ajst-6290	49	5	new	new	ADJ
ajst-6290	49	6	chapter	chapter	NOUN
ajst-6290	49	7	in	in	ADP
ajst-6290	49	8	genetic	genetic	ADJ
ajst-6290	49	9	engineering	engineering	NOUN
ajst-6290	49	10	and	and	CCONJ
ajst-6290	49	11	synthetic	synthetic	ADJ
ajst-6290	49	12	biology	biology	NOUN
ajst-6290	49	13	.	.	PUNCT
ajst-6290	50	1	2.3.3	2.3.3	NUM
ajst-6290	50	2	.	.	X
ajst-6290	50	3	stanley	stanley	PROPN
ajst-6290	50	4	cohen	cohen	PROPN
ajst-6290	50	5	stanley	stanley	PROPN
ajst-6290	50	6	cohen	cohen	PROPN
ajst-6290	50	7	is	be	AUX
ajst-6290	50	8	also	also	ADV
ajst-6290	50	9	one	one	NUM
ajst-6290	50	10	of	of	ADP
ajst-6290	50	11	the	the	DET
ajst-6290	50	12	important	important	ADJ
ajst-6290	50	13	founders	founder	NOUN
ajst-6290	50	14	of	of	ADP
ajst-6290	50	15	synthetic	synthetic	ADJ
ajst-6290	50	16	biology	biology	NOUN
ajst-6290	50	17	.	.	PUNCT
ajst-6290	51	1	together	together	ADV
ajst-6290	51	2	with	with	ADP
ajst-6290	51	3	herbert	herbert	PROPN
ajst-6290	51	4	boyer	boyer	PROPN
ajst-6290	51	5	,	,	PUNCT
ajst-6290	51	6	he	he	PRON
ajst-6290	51	7	worked	work	VERB
ajst-6290	51	8	on	on	ADP
ajst-6290	51	9	recombinant	recombinant	ADJ
ajst-6290	51	10	gene	gene	NOUN
ajst-6290	51	11	technology	technology	NOUN
ajst-6290	51	12	and	and	CCONJ
ajst-6290	51	13	applied	apply	VERB
ajst-6290	51	14	this	this	DET
ajst-6290	51	15	technology	technology	NOUN
ajst-6290	51	16	to	to	ADP
ajst-6290	51	17	the	the	DET
ajst-6290	51	18	construction	construction	NOUN
ajst-6290	51	19	of	of	ADP
ajst-6290	51	20	biomolecules	biomolecule	NOUN
ajst-6290	51	21	with	with	ADP
ajst-6290	51	22	new	new	ADJ
ajst-6290	51	23	functions	function	NOUN
ajst-6290	51	24	.	.	PUNCT
ajst-6290	52	1	cohen	cohen	PROPN
ajst-6290	52	2	also	also	ADV
ajst-6290	52	3	developed	develop	VERB
ajst-6290	52	4	a	a	DET
ajst-6290	52	5	gene	gene	NOUN
ajst-6290	52	6	transfer	transfer	NOUN
ajst-6290	52	7	technique	technique	NOUN
ajst-6290	52	8	,	,	PUNCT
ajst-6290	52	9	called	call	VERB
ajst-6290	52	10	"	"	PUNCT
ajst-6290	52	11	transformation	transformation	NOUN
ajst-6290	52	12	"	"	PUNCT
ajst-6290	52	13	,	,	PUNCT
ajst-6290	52	14	which	which	PRON
ajst-6290	52	15	plays	play	VERB
ajst-6290	52	16	an	an	DET
ajst-6290	52	17	important	important	ADJ
ajst-6290	52	18	role	role	NOUN
ajst-6290	52	19	in	in	ADP
ajst-6290	52	20	the	the	DET
ajst-6290	52	21	introduction	introduction	NOUN
ajst-6290	52	22	of	of	ADP
ajst-6290	52	23	dna	dna	PROPN
ajst-6290	52	24	into	into	ADP
ajst-6290	52	25	cells	cell	NOUN
ajst-6290	52	26	[	[	X
ajst-6290	52	27	6	6	NUM
ajst-6290	52	28	]	]	PUNCT
ajst-6290	52	29	.	.	PUNCT
ajst-6290	53	1	the	the	DET
ajst-6290	53	2	results	result	NOUN
ajst-6290	53	3	of	of	ADP
ajst-6290	53	4	cohen	cohen	PROPN
ajst-6290	53	5	and	and	CCONJ
ajst-6290	53	6	boyer	boyer	PROPN
ajst-6290	53	7	laid	lay	VERB
ajst-6290	53	8	the	the	DET
ajst-6290	53	9	foundation	foundation	NOUN
ajst-6290	53	10	for	for	ADP
ajst-6290	53	11	the	the	DET
ajst-6290	53	12	development	development	NOUN
ajst-6290	53	13	of	of	ADP
ajst-6290	53	14	genetic	genetic	ADJ
ajst-6290	53	15	engineering	engineering	NOUN
ajst-6290	53	16	and	and	CCONJ
ajst-6290	53	17	synthetic	synthetic	ADJ
ajst-6290	53	18	biology	biology	NOUN
ajst-6290	53	19	.	.	PUNCT
ajst-6290	54	1	2.3.4	2.3.4	X
ajst-6290	54	2	.	.	PUNCT
ajst-6290	54	3	research	research	NOUN
ajst-6290	54	4	by	by	ADP
ajst-6290	54	5	other	other	ADJ
ajst-6290	54	6	early	early	ADJ
ajst-6290	54	7	synthetic	synthetic	ADJ
ajst-6290	54	8	biologists	biologist	NOUN
ajst-6290	54	9	in	in	ADP
ajst-6290	54	10	addition	addition	NOUN
ajst-6290	54	11	to	to	ADP
ajst-6290	54	12	the	the	DET
ajst-6290	54	13	three	three	NUM
ajst-6290	54	14	key	key	ADJ
ajst-6290	54	15	figures	figure	NOUN
ajst-6290	54	16	mentioned	mention	VERB
ajst-6290	54	17	above	above	ADV
ajst-6290	54	18	,	,	PUNCT
ajst-6290	54	19	other	other	ADJ
ajst-6290	54	20	early	early	ADJ
ajst-6290	54	21	synthetic	synthetic	ADJ
ajst-6290	54	22	biologists	biologist	NOUN
ajst-6290	54	23	made	make	VERB
ajst-6290	54	24	many	many	ADJ
ajst-6290	54	25	important	important	ADJ
ajst-6290	54	26	contributions	contribution	NOUN
ajst-6290	54	27	.	.	PUNCT
ajst-6290	55	1	for	for	ADP
ajst-6290	55	2	example	example	NOUN
ajst-6290	55	3	,	,	PUNCT
ajst-6290	55	4	joseph	joseph	PROPN
ajst-6290	55	5	lederberg	lederberg	PROPN
ajst-6290	55	6	and	and	CCONJ
ajst-6290	55	7	edward	edward	PROPN
ajst-6290	55	8	tatum	tatum	PROPN
ajst-6290	55	9	discovered	discover	VERB
ajst-6290	55	10	the	the	DET
ajst-6290	55	11	phenomenon	phenomenon	NOUN
ajst-6290	55	12	of	of	ADP
ajst-6290	55	13	bacterial	bacterial	ADJ
ajst-6290	55	14	gene	gene	NOUN
ajst-6290	55	15	transfer	transfer	NOUN
ajst-6290	55	16	[	[	X
ajst-6290	55	17	7	7	NUM
ajst-6290	55	18	]	]	PUNCT
ajst-6290	55	19	,	,	PUNCT
ajst-6290	55	20	which	which	PRON
ajst-6290	55	21	provided	provide	VERB
ajst-6290	55	22	an	an	DET
ajst-6290	55	23	important	important	ADJ
ajst-6290	55	24	theoretical	theoretical	ADJ
ajst-6290	55	25	basis	basis	NOUN
ajst-6290	55	26	for	for	ADP
ajst-6290	55	27	later	later	ADJ
ajst-6290	55	28	genetic	genetic	ADJ
ajst-6290	55	29	engineering	engineering	NOUN
ajst-6290	55	30	and	and	CCONJ
ajst-6290	55	31	synthetic	synthetic	ADJ
ajst-6290	55	32	biology	biology	NOUN
ajst-6290	55	33	.	.	PUNCT
ajst-6290	56	1	in	in	ADP
ajst-6290	56	2	addition	addition	NOUN
ajst-6290	56	3	,	,	PUNCT
ajst-6290	56	4	david	david	PROPN
ajst-6290	56	5	blair	blair	PROPN
ajst-6290	56	6	and	and	CCONJ
ajst-6290	56	7	allen	allen	PROPN
ajst-6290	56	8	oppenheim	oppenheim	PROPN
ajst-6290	56	9	also	also	ADV
ajst-6290	56	10	made	make	VERB
ajst-6290	56	11	important	important	ADJ
ajst-6290	56	12	contributions	contribution	NOUN
ajst-6290	56	13	in	in	ADP
ajst-6290	56	14	early	early	ADJ
ajst-6290	56	15	synthetic	synthetic	ADJ
ajst-6290	56	16	biology	biology	NOUN
ajst-6290	56	17	[	[	X
ajst-6290	56	18	8	8	NUM
ajst-6290	56	19	]	]	PUNCT
ajst-6290	56	20	.	.	PUNCT
ajst-6290	57	1	overall	overall	ADV
ajst-6290	57	2	,	,	PUNCT
ajst-6290	57	3	the	the	DET
ajst-6290	57	4	research	research	NOUN
ajst-6290	57	5	in	in	ADP
ajst-6290	57	6	early	early	ADJ
ajst-6290	57	7	synthetic	synthetic	ADJ
ajst-6290	57	8	biology	biology	NOUN
ajst-6290	57	9	laid	lay	VERB
ajst-6290	57	10	the	the	DET
ajst-6290	57	11	foundation	foundation	NOUN
ajst-6290	57	12	for	for	ADP
ajst-6290	57	13	modern	modern	ADJ
ajst-6290	57	14	biotechnology	biotechnology	NOUN
ajst-6290	57	15	and	and	CCONJ
ajst-6290	57	16	had	have	VERB
ajst-6290	57	17	a	a	DET
ajst-6290	57	18	great	great	ADJ
ajst-6290	57	19	impact	impact	NOUN
ajst-6290	57	20	in	in	ADP
ajst-6290	57	21	the	the	DET
ajst-6290	57	22	fields	field	NOUN
ajst-6290	57	23	of	of	ADP
ajst-6290	57	24	medicine	medicine	NOUN
ajst-6290	57	25	,	,	PUNCT
ajst-6290	57	26	agriculture	agriculture	NOUN
ajst-6290	57	27	,	,	PUNCT
ajst-6290	57	28	and	and	CCONJ
ajst-6290	57	29	the	the	DET
ajst-6290	57	30	environment	environment	NOUN
ajst-6290	57	31	.	.	PUNCT
ajst-6290	58	1	3	3	X
ajst-6290	58	2	.	.	X
ajst-6290	58	3	modern	modern	ADJ
ajst-6290	58	4	synthetic	synthetic	ADJ
ajst-6290	58	5	biology	biology	NOUN
ajst-6290	58	6	(	(	PUNCT
ajst-6290	58	7	2000	2000	NUM
ajst-6290	58	8	to	to	PART
ajst-6290	58	9	present	present	VERB
ajst-6290	58	10	)	)	PUNCT
ajst-6290	58	11	3.1	3.1	NUM
ajst-6290	58	12	.	.	PUNCT
ajst-6290	59	1	convergence	convergence	NOUN
ajst-6290	59	2	of	of	ADP
ajst-6290	59	3	systems	system	NOUN
ajst-6290	59	4	biology	biology	NOUN
ajst-6290	59	5	and	and	CCONJ
ajst-6290	59	6	synthetic	synthetic	ADJ
ajst-6290	59	7	biology	biology	NOUN
ajst-6290	59	8	before	before	ADP
ajst-6290	59	9	2000	2000	NUM
ajst-6290	59	10	,	,	PUNCT
ajst-6290	59	11	research	research	NOUN
ajst-6290	59	12	in	in	ADP
ajst-6290	59	13	synthetic	synthetic	ADJ
ajst-6290	59	14	biology	biology	NOUN
ajst-6290	59	15	was	be	AUX
ajst-6290	59	16	mainly	mainly	ADV
ajst-6290	59	17	focused	focus	VERB
ajst-6290	59	18	on	on	ADP
ajst-6290	59	19	constructing	construct	VERB
ajst-6290	59	20	gene	gene	NOUN
ajst-6290	59	21	networks	network	NOUN
ajst-6290	59	22	and	and	CCONJ
ajst-6290	59	23	exploring	explore	VERB
ajst-6290	59	24	the	the	DET
ajst-6290	59	25	regulation	regulation	NOUN
ajst-6290	59	26	of	of	ADP
ajst-6290	59	27	gene	gene	NOUN
ajst-6290	59	28	expression	expression	NOUN
ajst-6290	59	29	.	.	PUNCT
ajst-6290	60	1	and	and	CCONJ
ajst-6290	60	2	since	since	SCONJ
ajst-6290	60	3	2000	2000	NUM
ajst-6290	60	4	,	,	PUNCT
ajst-6290	60	5	with	with	ADP
ajst-6290	60	6	the	the	DET
ajst-6290	60	7	development	development	NOUN
ajst-6290	60	8	of	of	ADP
ajst-6290	60	9	technology	technology	NOUN
ajst-6290	60	10	and	and	CCONJ
ajst-6290	60	11	the	the	DET
ajst-6290	60	12	intersection	intersection	NOUN
ajst-6290	60	13	of	of	ADP
ajst-6290	60	14	disciplines	discipline	NOUN
ajst-6290	60	15	,	,	PUNCT
ajst-6290	60	16	synthetic	synthetic	ADJ
ajst-6290	60	17	biology	biology	NOUN
ajst-6290	60	18	has	have	AUX
ajst-6290	60	19	further	far	ADV
ajst-6290	60	20	expanded	expand	VERB
ajst-6290	60	21	into	into	ADP
ajst-6290	60	22	a	a	DET
ajst-6290	60	23	kind	kind	NOUN
ajst-6290	60	24	of	of	ADP
ajst-6290	60	25	interdisciplinary	interdisciplinary	ADJ
ajst-6290	60	26	research	research	NOUN
ajst-6290	60	27	field	field	NOUN
ajst-6290	60	28	,	,	PUNCT
ajst-6290	60	29	combining	combine	VERB
ajst-6290	60	30	basic	basic	ADJ
ajst-6290	60	31	biology	biology	NOUN
ajst-6290	60	32	,	,	PUNCT
ajst-6290	60	33	engineering	engineering	NOUN
ajst-6290	60	34	and	and	CCONJ
ajst-6290	60	35	computer	computer	NOUN
ajst-6290	60	36	science	science	NOUN
ajst-6290	60	37	,	,	PUNCT
ajst-6290	60	38	and	and	CCONJ
ajst-6290	60	39	becoming	become	VERB
ajst-6290	60	40	a	a	DET
ajst-6290	60	41	frontier	frontier	NOUN
ajst-6290	60	42	area	area	NOUN
ajst-6290	60	43	for	for	ADP
ajst-6290	60	44	constructing	construct	VERB
ajst-6290	60	45	novel	novel	ADJ
ajst-6290	60	46	biological	biological	ADJ
ajst-6290	60	47	systems	system	NOUN
ajst-6290	60	48	and	and	CCONJ
ajst-6290	60	49	exploring	explore	VERB
ajst-6290	60	50	biology	biology	NOUN
ajst-6290	60	51	.	.	PUNCT
ajst-6290	61	1	during	during	ADP
ajst-6290	61	2	this	this	DET
ajst-6290	61	3	period	period	NOUN
ajst-6290	61	4	,	,	PUNCT
ajst-6290	61	5	advances	advance	NOUN
ajst-6290	61	6	in	in	ADP
ajst-6290	61	7	synthetic	synthetic	ADJ
ajst-6290	61	8	biology	biology	NOUN
ajst-6290	61	9	have	have	AUX
ajst-6290	61	10	intertwined	intertwine	VERB
ajst-6290	61	11	with	with	ADP
ajst-6290	61	12	developments	development	NOUN
ajst-6290	61	13	in	in	ADP
ajst-6290	61	14	systems	system	NOUN
ajst-6290	61	15	biology	biology	NOUN
ajst-6290	61	16	,	,	PUNCT
ajst-6290	61	17	resulting	result	VERB
ajst-6290	61	18	in	in	ADP
ajst-6290	61	19	new	new	ADJ
ajst-6290	61	20	research	research	NOUN
ajst-6290	61	21	directions	direction	NOUN
ajst-6290	61	22	and	and	CCONJ
ajst-6290	61	23	approaches	approach	NOUN
ajst-6290	61	24	,	,	PUNCT
ajst-6290	61	25	and	and	CCONJ
ajst-6290	61	26	successful	successful	ADJ
ajst-6290	61	27	applications	application	NOUN
ajst-6290	61	28	have	have	AUX
ajst-6290	61	29	been	be	AUX
ajst-6290	61	30	achieved	achieve	VERB
ajst-6290	61	31	in	in	ADP
ajst-6290	61	32	many	many	ADJ
ajst-6290	61	33	fields	field	NOUN
ajst-6290	61	34	.	.	PUNCT
ajst-6290	62	1	typical	typical	ADJ
ajst-6290	62	2	applications	application	NOUN
ajst-6290	62	3	include	include	VERB
ajst-6290	62	4	:	:	PUNCT
ajst-6290	62	5	synthetic	synthetic	ADJ
ajst-6290	62	6	biological	biological	ADJ
ajst-6290	62	7	systems	system	NOUN
ajst-6290	62	8	:	:	PUNCT
ajst-6290	62	9	the	the	DET
ajst-6290	62	10	combination	combination	NOUN
ajst-6290	62	11	of	of	ADP
ajst-6290	62	12	systems	system	NOUN
ajst-6290	62	13	biology	biology	NOUN
ajst-6290	62	14	and	and	CCONJ
ajst-6290	62	15	synthetic	synthetic	ADJ
ajst-6290	62	16	biology	biology	NOUN
ajst-6290	62	17	has	have	AUX
ajst-6290	62	18	provided	provide	VERB
ajst-6290	62	19	a	a	DET
ajst-6290	62	20	way	way	NOUN
ajst-6290	62	21	to	to	PART
ajst-6290	62	22	artificially	artificially	ADV
ajst-6290	62	23	construct	construct	VERB
ajst-6290	62	24	biological	biological	ADJ
ajst-6290	62	25	systems	system	NOUN
ajst-6290	62	26	,	,	PUNCT
ajst-6290	62	27	i.e.	i.e.	X
ajst-6290	62	28	,	,	PUNCT
ajst-6290	62	29	to	to	PART
ajst-6290	62	30	design	design	VERB
ajst-6290	62	31	and	and	CCONJ
ajst-6290	62	32	construct	construct	VERB
ajst-6290	62	33	artificial	artificial	ADJ
ajst-6290	62	34	biological	biological	ADJ
ajst-6290	62	35	systems	system	NOUN
ajst-6290	62	36	using	use	VERB
ajst-6290	62	37	known	know	VERB
ajst-6290	62	38	metabolic	metabolic	NOUN
ajst-6290	62	39	pathways	pathway	NOUN
ajst-6290	62	40	and	and	CCONJ
ajst-6290	62	41	reaction	reaction	NOUN
ajst-6290	62	42	pathways	pathway	NOUN
ajst-6290	62	43	to	to	PART
ajst-6290	62	44	achieve	achieve	VERB
ajst-6290	62	45	specific	specific	ADJ
ajst-6290	62	46	biological	biological	ADJ
ajst-6290	62	47	functions	function	NOUN
ajst-6290	62	48	.	.	PUNCT
ajst-6290	63	1	for	for	ADP
ajst-6290	63	2	example	example	NOUN
ajst-6290	63	3	,	,	PUNCT
ajst-6290	63	4	researchers	researcher	NOUN
ajst-6290	63	5	have	have	AUX
ajst-6290	63	6	used	use	VERB
ajst-6290	63	7	synthetic	synthetic	ADJ
ajst-6290	63	8	biology	biology	NOUN
ajst-6290	63	9	techniques	technique	NOUN
ajst-6290	63	10	to	to	PART
ajst-6290	63	11	construct	construct	VERB
ajst-6290	63	12	an	an	DET
ajst-6290	63	13	artificial	artificial	ADJ
ajst-6290	63	14	synthetic	synthetic	ADJ
ajst-6290	63	15	biological	biological	ADJ
ajst-6290	63	16	system	system	NOUN
ajst-6290	63	17	that	that	PRON
ajst-6290	63	18	can	can	AUX
ajst-6290	63	19	synthesize	synthesize	VERB
ajst-6290	63	20	high	high	ADJ
ajst-6290	63	21	valueadded	valueadde	VERB
ajst-6290	63	22	compounds	compound	NOUN
ajst-6290	63	23	such	such	ADJ
ajst-6290	63	24	as	as	ADP
ajst-6290	63	25	butene	butene	NOUN
ajst-6290	63	26	and	and	CCONJ
ajst-6290	63	27	butadiene	butadiene	NOUN
ajst-6290	63	28	from	from	ADP
ajst-6290	63	29	simple	simple	ADJ
ajst-6290	63	30	substances	substance	NOUN
ajst-6290	63	31	such	such	ADJ
ajst-6290	63	32	as	as	ADP
ajst-6290	63	33	methane	methane	NOUN
ajst-6290	63	34	and	and	CCONJ
ajst-6290	63	35	carbon	carbon	NOUN
ajst-6290	63	36	dioxide	dioxide	NOUN
ajst-6290	64	1	[	[	X
ajst-6290	64	2	9	9	NUM
ajst-6290	64	3	-	-	SYM
ajst-6290	64	4	11	11	NUM
ajst-6290	64	5	]	]	PUNCT
ajst-6290	64	6	.	.	PUNCT
ajst-6290	65	1	network	network	NOUN
ajst-6290	65	2	controller	controller	NOUN
ajst-6290	65	3	design	design	NOUN
ajst-6290	65	4	:	:	PUNCT
ajst-6290	65	5	synthetic	synthetic	ADJ
ajst-6290	65	6	biology	biology	NOUN
ajst-6290	65	7	techniques	technique	NOUN
ajst-6290	65	8	can	can	AUX
ajst-6290	65	9	be	be	AUX
ajst-6290	65	10	used	use	VERB
ajst-6290	65	11	to	to	PART
ajst-6290	65	12	design	design	VERB
ajst-6290	65	13	and	and	CCONJ
ajst-6290	65	14	construct	construct	VERB
ajst-6290	65	15	gene	gene	NOUN
ajst-6290	65	16	networks	network	NOUN
ajst-6290	65	17	with	with	ADP
ajst-6290	65	18	specific	specific	ADJ
ajst-6290	65	19	functions	function	NOUN
ajst-6290	65	20	,	,	PUNCT
ajst-6290	65	21	while	while	SCONJ
ajst-6290	65	22	systems	system	NOUN
ajst-6290	65	23	biology	biology	NOUN
ajst-6290	65	24	techniques	technique	NOUN
ajst-6290	65	25	can	can	AUX
ajst-6290	65	26	be	be	AUX
ajst-6290	65	27	used	use	VERB
ajst-6290	65	28	to	to	PART
ajst-6290	65	29	study	study	VERB
ajst-6290	65	30	the	the	DET
ajst-6290	65	31	mechanisms	mechanism	NOUN
ajst-6290	65	32	by	by	ADP
ajst-6290	65	33	which	which	PRON
ajst-6290	65	34	these	these	DET
ajst-6290	65	35	networks	network	NOUN
ajst-6290	65	36	operate	operate	VERB
ajst-6290	65	37	.	.	PUNCT
ajst-6290	66	1	by	by	ADP
ajst-6290	66	2	systematically	systematically	ADV
ajst-6290	66	3	studying	study	VERB
ajst-6290	66	4	the	the	DET
ajst-6290	66	5	structural	structural	ADJ
ajst-6290	66	6	and	and	CCONJ
ajst-6290	66	7	dynamic	dynamic	ADJ
ajst-6290	66	8	properties	property	NOUN
ajst-6290	66	9	of	of	ADP
ajst-6290	66	10	these	these	DET
ajst-6290	66	11	gene	gene	NOUN
ajst-6290	66	12	networks	network	NOUN
ajst-6290	66	13	,	,	PUNCT
ajst-6290	66	14	efficient	efficient	ADJ
ajst-6290	66	15	network	network	NOUN
ajst-6290	66	16	controllers	controller	NOUN
ajst-6290	66	17	can	can	AUX
ajst-6290	66	18	be	be	AUX
ajst-6290	66	19	designed	design	VERB
ajst-6290	66	20	to	to	PART
ajst-6290	66	21	achieve	achieve	VERB
ajst-6290	66	22	precise	precise	ADJ
ajst-6290	66	23	control	control	NOUN
ajst-6290	66	24	of	of	ADP
ajst-6290	66	25	biological	biological	ADJ
ajst-6290	66	26	processes	process	NOUN
ajst-6290	66	27	.	.	PUNCT
ajst-6290	67	1	for	for	ADP
ajst-6290	67	2	example	example	NOUN
ajst-6290	67	3	,	,	PUNCT
ajst-6290	67	4	researchers	researcher	NOUN
ajst-6290	67	5	have	have	AUX
ajst-6290	67	6	used	use	VERB
ajst-6290	67	7	this	this	DET
ajst-6290	67	8	approach	approach	NOUN
ajst-6290	67	9	to	to	PART
ajst-6290	67	10	design	design	VERB
ajst-6290	67	11	a	a	DET
ajst-6290	67	12	gene	gene	NOUN
ajst-6290	67	13	network	network	NOUN
ajst-6290	67	14	that	that	PRON
ajst-6290	67	15	can	can	AUX
ajst-6290	67	16	precisely	precisely	ADV
ajst-6290	67	17	control	control	VERB
ajst-6290	67	18	the	the	DET
ajst-6290	67	19	metabolic	metabolic	NOUN
ajst-6290	67	20	pathways	pathway	NOUN
ajst-6290	67	21	of	of	ADP
ajst-6290	67	22	brewer	brewer	NOUN
ajst-6290	67	23	's	's	PART
ajst-6290	67	24	yeast	yeast	NOUN
ajst-6290	67	25	,	,	PUNCT
ajst-6290	67	26	thus	thus	ADV
ajst-6290	67	27	enabling	enable	VERB
ajst-6290	67	28	the	the	DET
ajst-6290	67	29	regulation	regulation	NOUN
ajst-6290	67	30	of	of	ADP
ajst-6290	67	31	ethanol	ethanol	NOUN
ajst-6290	67	32	production	production	NOUN
ajst-6290	67	33	[	[	X
ajst-6290	67	34	12	12	NUM
ajst-6290	67	35	-	-	SYM
ajst-6290	67	36	13	13	NUM
ajst-6290	67	37	]	]	PUNCT
ajst-6290	67	38	.	.	PUNCT
ajst-6290	68	1	metabolic	metabolic	PROPN
ajst-6290	68	2	engineering	engineering	PROPN
ajst-6290	68	3	:	:	PUNCT
ajst-6290	68	4	the	the	DET
ajst-6290	68	5	combination	combination	NOUN
ajst-6290	68	6	of	of	ADP
ajst-6290	68	7	synthetic	synthetic	ADJ
ajst-6290	68	8	biology	biology	NOUN
ajst-6290	68	9	and	and	CCONJ
ajst-6290	68	10	systems	system	NOUN
ajst-6290	68	11	biology	biology	NOUN
ajst-6290	68	12	can	can	AUX
ajst-6290	68	13	also	also	ADV
ajst-6290	68	14	be	be	AUX
ajst-6290	68	15	used	use	VERB
ajst-6290	68	16	to	to	PART
ajst-6290	68	17	achieve	achieve	VERB
ajst-6290	68	18	the	the	DET
ajst-6290	68	19	reconfiguration	reconfiguration	NOUN
ajst-6290	68	20	and	and	CCONJ
ajst-6290	68	21	optimization	optimization	NOUN
ajst-6290	68	22	of	of	ADP
ajst-6290	68	23	metabolic	metabolic	NOUN
ajst-6290	68	24	pathways	pathway	NOUN
ajst-6290	68	25	.	.	PUNCT
ajst-6290	69	1	synthetic	synthetic	ADJ
ajst-6290	69	2	biology	biology	NOUN
ajst-6290	69	3	techniques	technique	NOUN
ajst-6290	69	4	can	can	AUX
ajst-6290	69	5	be	be	AUX
ajst-6290	69	6	used	use	VERB
ajst-6290	69	7	to	to	PART
ajst-6290	69	8	construct	construct	VERB
ajst-6290	69	9	and	and	CCONJ
ajst-6290	69	10	optimize	optimize	VERB
ajst-6290	69	11	metabolic	metabolic	NOUN
ajst-6290	69	12	pathways	pathway	NOUN
ajst-6290	69	13	,	,	PUNCT
ajst-6290	69	14	while	while	SCONJ
ajst-6290	69	15	systems	system	NOUN
ajst-6290	69	16	biology	biology	NOUN
ajst-6290	69	17	techniques	technique	NOUN
ajst-6290	69	18	can	can	AUX
ajst-6290	69	19	be	be	AUX
ajst-6290	69	20	used	use	VERB
ajst-6290	69	21	to	to	PART
ajst-6290	69	22	analyze	analyze	VERB
ajst-6290	69	23	the	the	DET
ajst-6290	69	24	structural	structural	ADJ
ajst-6290	69	25	and	and	CCONJ
ajst-6290	69	26	dynamic	dynamic	ADJ
ajst-6290	69	27	properties	property	NOUN
ajst-6290	69	28	of	of	ADP
ajst-6290	69	29	metabolic	metabolic	NOUN
ajst-6290	69	30	networks	network	NOUN
ajst-6290	69	31	to	to	PART
ajst-6290	69	32	achieve	achieve	VERB
ajst-6290	69	33	fine	fine	ADJ
ajst-6290	69	34	regulation	regulation	NOUN
ajst-6290	69	35	of	of	ADP
ajst-6290	69	36	metabolic	metabolic	NOUN
ajst-6290	69	37	pathways	pathway	NOUN
ajst-6290	69	38	.	.	PUNCT
ajst-6290	70	1	for	for	ADP
ajst-6290	70	2	example	example	NOUN
ajst-6290	70	3	,	,	PUNCT
ajst-6290	70	4	researchers	researcher	NOUN
ajst-6290	70	5	have	have	AUX
ajst-6290	70	6	used	use	VERB
ajst-6290	70	7	this	this	DET
ajst-6290	70	8	approach	approach	NOUN
ajst-6290	70	9	to	to	PART
ajst-6290	70	10	achieve	achieve	VERB
ajst-6290	70	11	optimization	optimization	NOUN
ajst-6290	70	12	of	of	ADP
ajst-6290	70	13	the	the	DET
ajst-6290	70	14	ethanol	ethanol	NOUN
ajst-6290	70	15	metabolic	metabolic	NOUN
ajst-6290	70	16	pathway	pathway	NOUN
ajst-6290	70	17	in	in	ADP
ajst-6290	70	18	brewer	brewer	NOUN
ajst-6290	70	19	's	's	PART
ajst-6290	70	20	yeast	yeast	NOUN
ajst-6290	70	21	,	,	PUNCT
ajst-6290	70	22	resulting	result	VERB
ajst-6290	70	23	in	in	ADP
ajst-6290	70	24	a	a	DET
ajst-6290	70	25	nearly	nearly	ADV
ajst-6290	70	26	10	10	NUM
ajst-6290	70	27	-	-	ADJ
ajst-6290	70	28	fold	fold	ADJ
ajst-6290	70	29	increase	increase	NOUN
ajst-6290	70	30	in	in	ADP
ajst-6290	70	31	ethanol	ethanol	NOUN
ajst-6290	70	32	production	production	NOUN
ajst-6290	70	33	[	[	X
ajst-6290	70	34	14	14	NUM
ajst-6290	70	35	-	-	SYM
ajst-6290	70	36	16	16	NUM
ajst-6290	70	37	]	]	PUNCT
ajst-6290	70	38	.	.	PUNCT
ajst-6290	71	1	3.2	3.2	NUM
ajst-6290	71	2	.	.	PUNCT
ajst-6290	72	1	development	development	NOUN
ajst-6290	72	2	of	of	ADP
ajst-6290	72	3	dna	dna	PROPN
ajst-6290	72	4	synthesis	synthesis	NOUN
ajst-6290	72	5	,	,	PUNCT
ajst-6290	72	6	assembly	assembly	NOUN
ajst-6290	72	7	and	and	CCONJ
ajst-6290	72	8	editing	edit	VERB
ajst-6290	72	9	technologies	technology	NOUN
ajst-6290	72	10	one	one	NUM
ajst-6290	72	11	of	of	ADP
ajst-6290	72	12	the	the	DET
ajst-6290	72	13	important	important	ADJ
ajst-6290	72	14	technological	technological	ADJ
ajst-6290	72	15	advances	advance	NOUN
ajst-6290	72	16	in	in	ADP
ajst-6290	72	17	synthetic	synthetic	ADJ
ajst-6290	72	18	biology	biology	NOUN
ajst-6290	72	19	is	be	AUX
ajst-6290	72	20	the	the	DET
ajst-6290	72	21	development	development	NOUN
ajst-6290	72	22	of	of	ADP
ajst-6290	72	23	dna	dna	PROPN
ajst-6290	72	24	synthesis	synthesis	NOUN
ajst-6290	72	25	,	,	PUNCT
ajst-6290	72	26	assembly	assembly	NOUN
ajst-6290	72	27	and	and	CCONJ
ajst-6290	72	28	editing	editing	NOUN
ajst-6290	72	29	technologies	technology	NOUN
ajst-6290	72	30	.	.	PUNCT
ajst-6290	73	1	the	the	DET
ajst-6290	73	2	advent	advent	NOUN
ajst-6290	73	3	of	of	ADP
ajst-6290	73	4	pcr	pcr	NOUN
ajst-6290	73	5	-	-	PUNCT
ajst-6290	73	6	based	base	VERB
ajst-6290	73	7	dna	dna	NOUN
ajst-6290	73	8	synthesis	synthesis	NOUN
ajst-6290	73	9	techniques	technique	NOUN
ajst-6290	73	10	has	have	AUX
ajst-6290	73	11	made	make	VERB
ajst-6290	73	12	it	it	PRON
ajst-6290	73	13	possible	possible	ADJ
ajst-6290	73	14	to	to	PART
ajst-6290	73	15	synthesize	synthesize	VERB
ajst-6290	73	16	longer	long	ADV
ajst-6290	73	17	97	97	NUM
ajst-6290	73	18	dna	dna	PROPN
ajst-6290	73	19	sequences	sequence	NOUN
ajst-6290	73	20	in	in	ADP
ajst-6290	73	21	a	a	DET
ajst-6290	73	22	short	short	ADJ
ajst-6290	73	23	time	time	NOUN
ajst-6290	73	24	[	[	X
ajst-6290	73	25	17	17	NUM
ajst-6290	73	26	]	]	PUNCT
ajst-6290	73	27	.	.	PUNCT
ajst-6290	74	1	in	in	ADP
ajst-6290	74	2	addition	addition	NOUN
ajst-6290	74	3	,	,	PUNCT
ajst-6290	74	4	dna	dna	PROPN
ajst-6290	74	5	assembly	assembly	NOUN
ajst-6290	74	6	based	base	VERB
ajst-6290	74	7	on	on	ADP
ajst-6290	74	8	pcr	pcr	ADJ
ajst-6290	74	9	technology	technology	NOUN
ajst-6290	74	10	allows	allow	VERB
ajst-6290	74	11	the	the	DET
ajst-6290	74	12	assembly	assembly	NOUN
ajst-6290	74	13	of	of	ADP
ajst-6290	74	14	multiple	multiple	ADJ
ajst-6290	74	15	dna	dna	PROPN
ajst-6290	74	16	fragments	fragment	NOUN
ajst-6290	74	17	into	into	ADP
ajst-6290	74	18	larger	large	ADJ
ajst-6290	74	19	dna	dna	NOUN
ajst-6290	74	20	sequences	sequence	NOUN
ajst-6290	74	21	[	[	X
ajst-6290	74	22	18	18	NUM
ajst-6290	74	23	]	]	PUNCT
ajst-6290	74	24	,	,	PUNCT
ajst-6290	74	25	and	and	CCONJ
ajst-6290	74	26	this	this	DET
ajst-6290	74	27	technology	technology	NOUN
ajst-6290	74	28	facilitates	facilitate	VERB
ajst-6290	74	29	the	the	DET
ajst-6290	74	30	construction	construction	NOUN
ajst-6290	74	31	of	of	ADP
ajst-6290	74	32	synthetic	synthetic	ADJ
ajst-6290	74	33	biological	biological	ADJ
ajst-6290	74	34	systems	system	NOUN
ajst-6290	74	35	.	.	PUNCT
ajst-6290	75	1	there	there	PRON
ajst-6290	75	2	are	be	VERB
ajst-6290	75	3	many	many	ADJ
ajst-6290	75	4	typical	typical	ADJ
ajst-6290	75	5	applications	application	NOUN
ajst-6290	75	6	,	,	PUNCT
ajst-6290	75	7	such	such	ADJ
ajst-6290	75	8	as	as	ADP
ajst-6290	75	9	microbial	microbial	ADJ
ajst-6290	75	10	routes	route	NOUN
ajst-6290	75	11	and	and	CCONJ
ajst-6290	75	12	dual	dual	ADJ
ajst-6290	75	13	enzymatic	enzymatic	ADJ
ajst-6290	75	14	methods	method	NOUN
ajst-6290	75	15	for	for	ADP
ajst-6290	75	16	ergothioneine	ergothioneine	NOUN
ajst-6290	75	17	,	,	PUNCT
ajst-6290	75	18	an	an	DET
ajst-6290	75	19	important	important	ADJ
ajst-6290	75	20	alkaloid	alkaloid	NOUN
ajst-6290	75	21	with	with	ADP
ajst-6290	75	22	a	a	DET
ajst-6290	75	23	wide	wide	ADJ
ajst-6290	75	24	range	range	NOUN
ajst-6290	75	25	of	of	ADP
ajst-6290	75	26	medicinal	medicinal	ADJ
ajst-6290	75	27	uses	use	NOUN
ajst-6290	75	28	.	.	PUNCT
ajst-6290	76	1	the	the	DET
ajst-6290	76	2	biosynthetic	biosynthetic	ADJ
ajst-6290	76	3	routes	route	NOUN
ajst-6290	76	4	of	of	ADP
ajst-6290	76	5	ergothioneine	ergothioneine	NOUN
ajst-6290	76	6	are	be	AUX
ajst-6290	76	7	divided	divide	VERB
ajst-6290	76	8	into	into	ADP
ajst-6290	76	9	two	two	NUM
ajst-6290	76	10	main	main	ADJ
ajst-6290	76	11	types	type	NOUN
ajst-6290	76	12	:	:	PUNCT
ajst-6290	76	13	microbial	microbial	ADJ
ajst-6290	76	14	routes	route	NOUN
ajst-6290	76	15	and	and	CCONJ
ajst-6290	76	16	plant	plant	NOUN
ajst-6290	76	17	routes	route	NOUN
ajst-6290	76	18	.	.	PUNCT
ajst-6290	77	1	the	the	DET
ajst-6290	77	2	microbial	microbial	ADJ
ajst-6290	77	3	route	route	NOUN
ajst-6290	77	4	refers	refer	VERB
ajst-6290	77	5	to	to	ADP
ajst-6290	77	6	the	the	DET
ajst-6290	77	7	biosynthesis	biosynthesis	NOUN
ajst-6290	77	8	of	of	ADP
ajst-6290	77	9	ergothioneine	ergothioneine	NOUN
ajst-6290	77	10	using	use	VERB
ajst-6290	77	11	microorganisms	microorganism	NOUN
ajst-6290	77	12	(	(	PUNCT
ajst-6290	77	13	e.g.	e.g.	ADV
ajst-6290	77	14	fungi	fungus	NOUN
ajst-6290	77	15	)	)	PUNCT
ajst-6290	77	16	.	.	PUNCT
ajst-6290	78	1	the	the	DET
ajst-6290	78	2	main	main	ADJ
ajst-6290	78	3	features	feature	NOUN
ajst-6290	78	4	of	of	ADP
ajst-6290	78	5	this	this	DET
ajst-6290	78	6	route	route	NOUN
ajst-6290	78	7	are	be	AUX
ajst-6290	78	8	high	high	ADJ
ajst-6290	78	9	production	production	NOUN
ajst-6290	78	10	efficiency	efficiency	NOUN
ajst-6290	78	11	,	,	PUNCT
ajst-6290	78	12	short	short	ADJ
ajst-6290	78	13	production	production	NOUN
ajst-6290	78	14	cycle	cycle	NOUN
ajst-6290	78	15	and	and	CCONJ
ajst-6290	78	16	easy	easy	ADJ
ajst-6290	78	17	control	control	NOUN
ajst-6290	78	18	of	of	ADP
ajst-6290	78	19	production	production	NOUN
ajst-6290	78	20	conditions	condition	NOUN
ajst-6290	78	21	.	.	PUNCT
ajst-6290	79	1	specifically	specifically	ADV
ajst-6290	79	2	,	,	PUNCT
ajst-6290	79	3	the	the	DET
ajst-6290	79	4	route	route	NOUN
ajst-6290	79	5	consists	consist	VERB
ajst-6290	79	6	of	of	ADP
ajst-6290	79	7	the	the	DET
ajst-6290	79	8	following	follow	VERB
ajst-6290	79	9	steps	step	NOUN
ajst-6290	79	10	:	:	PUNCT
ajst-6290	79	11	cloning	cloning	NOUN
ajst-6290	79	12	and	and	CCONJ
ajst-6290	79	13	expression	expression	NOUN
ajst-6290	79	14	of	of	ADP
ajst-6290	79	15	ergothioneine	ergothioneine	NOUN
ajst-6290	79	16	genes	gene	NOUN
ajst-6290	79	17	:	:	PUNCT
ajst-6290	79	18	scientists	scientist	NOUN
ajst-6290	79	19	have	have	AUX
ajst-6290	79	20	cloned	clone	VERB
ajst-6290	79	21	relevant	relevant	ADJ
ajst-6290	79	22	genes	gene	NOUN
ajst-6290	79	23	,	,	PUNCT
ajst-6290	79	24	including	include	VERB
ajst-6290	79	25	l	l	NOUN
ajst-6290	79	26	-	-	ADJ
ajst-6290	79	27	tyrosine	tyrosine	ADJ
ajst-6290	79	28	decarboxylase	decarboxylase	NOUN
ajst-6290	79	29	and	and	CCONJ
ajst-6290	79	30	tyrosol	tyrosol	NOUN
ajst-6290	79	31	dehydrogenase	dehydrogenase	NOUN
ajst-6290	79	32	,	,	PUNCT
ajst-6290	79	33	through	through	ADP
ajst-6290	79	34	the	the	DET
ajst-6290	79	35	study	study	NOUN
ajst-6290	79	36	of	of	ADP
ajst-6290	79	37	ergothioneine	ergothioneine	NOUN
ajst-6290	79	38	biosynthesis	biosynthesis	NOUN
ajst-6290	79	39	pathway	pathway	NOUN
ajst-6290	79	40	.	.	PUNCT
ajst-6290	80	1	these	these	DET
ajst-6290	80	2	genes	gene	NOUN
ajst-6290	80	3	,	,	PUNCT
ajst-6290	80	4	when	when	SCONJ
ajst-6290	80	5	expressed	express	VERB
ajst-6290	80	6	in	in	ADP
ajst-6290	80	7	microorganisms	microorganism	NOUN
ajst-6290	80	8	,	,	PUNCT
ajst-6290	80	9	can	can	AUX
ajst-6290	80	10	catalyze	catalyze	VERB
ajst-6290	80	11	the	the	DET
ajst-6290	80	12	production	production	NOUN
ajst-6290	80	13	of	of	ADP
ajst-6290	80	14	ergothioneine	ergothioneine	NOUN
ajst-6290	80	15	by	by	ADP
ajst-6290	80	16	substrates	substrate	NOUN
ajst-6290	80	17	.	.	PUNCT
ajst-6290	81	1	optimization	optimization	NOUN
ajst-6290	81	2	of	of	ADP
ajst-6290	81	3	metabolic	metabolic	NOUN
ajst-6290	81	4	pathways	pathway	NOUN
ajst-6290	81	5	:	:	PUNCT
ajst-6290	81	6	in	in	ADP
ajst-6290	81	7	order	order	NOUN
ajst-6290	81	8	to	to	PART
ajst-6290	81	9	improve	improve	VERB
ajst-6290	81	10	production	production	NOUN
ajst-6290	81	11	efficiency	efficiency	NOUN
ajst-6290	81	12	and	and	CCONJ
ajst-6290	81	13	yield	yield	NOUN
ajst-6290	81	14	,	,	PUNCT
ajst-6290	81	15	scientists	scientist	NOUN
ajst-6290	81	16	have	have	AUX
ajst-6290	81	17	optimized	optimize	VERB
ajst-6290	81	18	the	the	DET
ajst-6290	81	19	metabolic	metabolic	NOUN
ajst-6290	81	20	pathways	pathway	NOUN
ajst-6290	81	21	of	of	ADP
ajst-6290	81	22	microorganisms	microorganism	NOUN
ajst-6290	81	23	.	.	PUNCT
ajst-6290	82	1	these	these	DET
ajst-6290	82	2	optimizations	optimization	NOUN
ajst-6290	82	3	include	include	VERB
ajst-6290	82	4	increasing	increase	VERB
ajst-6290	82	5	substrate	substrate	NOUN
ajst-6290	82	6	supply	supply	NOUN
ajst-6290	82	7	,	,	PUNCT
ajst-6290	82	8	regulating	regulate	VERB
ajst-6290	82	9	metabolic	metabolic	NOUN
ajst-6290	82	10	pathways	pathway	NOUN
ajst-6290	82	11	,	,	PUNCT
ajst-6290	82	12	etc	etc	X
ajst-6290	82	13	.	.	X
ajst-6290	82	14	extraction	extraction	NOUN
ajst-6290	82	15	and	and	CCONJ
ajst-6290	82	16	purification	purification	NOUN
ajst-6290	82	17	of	of	ADP
ajst-6290	82	18	ergothioneine	ergothioneine	NOUN
ajst-6290	82	19	:	:	PUNCT
ajst-6290	82	20	the	the	DET
ajst-6290	82	21	produced	produce	VERB
ajst-6290	82	22	ergothioneine	ergothioneine	NOUN
ajst-6290	82	23	needs	need	VERB
ajst-6290	82	24	to	to	PART
ajst-6290	82	25	be	be	AUX
ajst-6290	82	26	extracted	extract	VERB
ajst-6290	82	27	and	and	CCONJ
ajst-6290	82	28	purified	purified	ADJ
ajst-6290	82	29	.	.	PUNCT
ajst-6290	83	1	these	these	DET
ajst-6290	83	2	steps	step	NOUN
ajst-6290	83	3	include	include	VERB
ajst-6290	83	4	microbial	microbial	ADJ
ajst-6290	83	5	culture	culture	NOUN
ajst-6290	83	6	,	,	PUNCT
ajst-6290	83	7	cell	cell	NOUN
ajst-6290	83	8	rupture	rupture	NOUN
ajst-6290	83	9	,	,	PUNCT
ajst-6290	83	10	extraction	extraction	NOUN
ajst-6290	83	11	,	,	PUNCT
ajst-6290	83	12	distillation	distillation	NOUN
ajst-6290	83	13	,	,	PUNCT
ajst-6290	83	14	etc	etc	X
ajst-6290	83	15	.	.	X
ajst-6290	83	16	compared	compare	VERB
ajst-6290	83	17	to	to	ADP
ajst-6290	83	18	the	the	DET
ajst-6290	83	19	plant	plant	NOUN
ajst-6290	83	20	route	route	NOUN
ajst-6290	83	21	,	,	PUNCT
ajst-6290	83	22	the	the	DET
ajst-6290	83	23	microbial	microbial	ADJ
ajst-6290	83	24	route	route	NOUN
ajst-6290	83	25	is	be	AUX
ajst-6290	83	26	a	a	DET
ajst-6290	83	27	more	more	ADV
ajst-6290	83	28	feasible	feasible	ADJ
ajst-6290	83	29	method	method	NOUN
ajst-6290	83	30	for	for	ADP
ajst-6290	83	31	the	the	DET
ajst-6290	83	32	production	production	NOUN
ajst-6290	83	33	of	of	ADP
ajst-6290	83	34	ergothioneine	ergothioneine	NOUN
ajst-6290	83	35	because	because	SCONJ
ajst-6290	83	36	of	of	ADP
ajst-6290	83	37	its	its	PRON
ajst-6290	83	38	low	low	ADJ
ajst-6290	83	39	production	production	NOUN
ajst-6290	83	40	cost	cost	NOUN
ajst-6290	83	41	,	,	PUNCT
ajst-6290	83	42	high	high	ADJ
ajst-6290	83	43	yield	yield	NOUN
ajst-6290	83	44	,	,	PUNCT
ajst-6290	83	45	and	and	CCONJ
ajst-6290	83	46	easy	easy	ADJ
ajst-6290	83	47	control	control	NOUN
ajst-6290	83	48	of	of	ADP
ajst-6290	83	49	the	the	DET
ajst-6290	83	50	process	process	NOUN
ajst-6290	83	51	conditions	condition	NOUN
ajst-6290	83	52	[	[	X
ajst-6290	83	53	19	19	NUM
ajst-6290	83	54	-	-	SYM
ajst-6290	83	55	20	20	NUM
ajst-6290	83	56	]	]	PUNCT
ajst-6290	83	57	.	.	PUNCT
ajst-6290	84	1	alternatively	alternatively	ADV
ajst-6290	84	2	,	,	PUNCT
ajst-6290	84	3	the	the	DET
ajst-6290	84	4	biosynthesis	biosynthesis	NOUN
ajst-6290	84	5	of	of	ADP
ajst-6290	84	6	ergothioneine	ergothioneine	NOUN
ajst-6290	84	7	can	can	AUX
ajst-6290	84	8	be	be	AUX
ajst-6290	84	9	performed	perform	VERB
ajst-6290	84	10	by	by	ADP
ajst-6290	84	11	a	a	DET
ajst-6290	84	12	dual	dual	ADJ
ajst-6290	84	13	enzyme	enzyme	NOUN
ajst-6290	84	14	method	method	NOUN
ajst-6290	84	15	.	.	PUNCT
ajst-6290	85	1	this	this	DET
ajst-6290	85	2	method	method	NOUN
ajst-6290	85	3	refers	refer	VERB
ajst-6290	85	4	to	to	ADP
ajst-6290	85	5	the	the	DET
ajst-6290	85	6	conversion	conversion	NOUN
ajst-6290	85	7	of	of	ADP
ajst-6290	85	8	the	the	DET
ajst-6290	85	9	substrate	substrate	NOUN
ajst-6290	85	10	to	to	ADP
ajst-6290	85	11	ergothioneine	ergothioneine	NOUN
ajst-6290	85	12	through	through	ADP
ajst-6290	85	13	the	the	DET
ajst-6290	85	14	tandem	tandem	PROPN
ajst-6290	85	15	catalysis	catalysis	NOUN
ajst-6290	85	16	of	of	ADP
ajst-6290	85	17	two	two	NUM
ajst-6290	85	18	enzymes	enzyme	NOUN
ajst-6290	85	19	.	.	PUNCT
ajst-6290	86	1	specifically	specifically	ADV
ajst-6290	86	2	,	,	PUNCT
ajst-6290	86	3	this	this	DET
ajst-6290	86	4	method	method	NOUN
ajst-6290	86	5	includes	include	VERB
ajst-6290	86	6	the	the	DET
ajst-6290	86	7	catalysis	catalysis	NOUN
ajst-6290	86	8	of	of	ADP
ajst-6290	86	9	two	two	NUM
ajst-6290	86	10	enzymes	enzyme	NOUN
ajst-6290	86	11	,	,	PUNCT
ajst-6290	86	12	l	l	NOUN
ajst-6290	86	13	-	-	ADJ
ajst-6290	86	14	tyrosine	tyrosine	ADJ
ajst-6290	86	15	decarboxylase	decarboxylase	NOUN
ajst-6290	86	16	and	and	CCONJ
ajst-6290	86	17	tyrosol	tyrosol	NOUN
ajst-6290	86	18	dehydrogenase	dehydrogenase	NOUN
ajst-6290	86	19	.	.	PUNCT
ajst-6290	87	1	compared	compare	VERB
ajst-6290	87	2	with	with	ADP
ajst-6290	87	3	the	the	DET
ajst-6290	87	4	microbial	microbial	ADJ
ajst-6290	87	5	route	route	NOUN
ajst-6290	87	6	,	,	PUNCT
ajst-6290	87	7	the	the	DET
ajst-6290	87	8	dual	dual	ADJ
ajst-6290	87	9	enzyme	enzyme	NOUN
ajst-6290	87	10	method	method	NOUN
ajst-6290	87	11	has	have	VERB
ajst-6290	87	12	the	the	DET
ajst-6290	87	13	advantages	advantage	NOUN
ajst-6290	87	14	of	of	ADP
ajst-6290	87	15	mild	mild	ADJ
ajst-6290	87	16	reaction	reaction	NOUN
ajst-6290	87	17	conditions	condition	NOUN
ajst-6290	87	18	and	and	CCONJ
ajst-6290	87	19	simple	simple	ADJ
ajst-6290	87	20	operation	operation	NOUN
ajst-6290	87	21	,	,	PUNCT
ajst-6290	87	22	but	but	CCONJ
ajst-6290	87	23	the	the	DET
ajst-6290	87	24	production	production	NOUN
ajst-6290	87	25	efficiency	efficiency	NOUN
ajst-6290	87	26	is	be	AUX
ajst-6290	87	27	low	low	ADJ
ajst-6290	87	28	and	and	CCONJ
ajst-6290	87	29	requires	require	VERB
ajst-6290	87	30	a	a	DET
ajst-6290	87	31	large	large	ADJ
ajst-6290	87	32	amount	amount	NOUN
ajst-6290	87	33	of	of	ADP
ajst-6290	87	34	enzyme	enzyme	NOUN
ajst-6290	87	35	catalysts	catalyst	NOUN
ajst-6290	87	36	and	and	CCONJ
ajst-6290	87	37	substrates	substrate	NOUN
ajst-6290	87	38	.	.	PUNCT
ajst-6290	88	1	recently	recently	ADV
ajst-6290	88	2	,	,	PUNCT
ajst-6290	88	3	the	the	DET
ajst-6290	88	4	gene	gene	NOUN
ajst-6290	88	5	editing	edit	VERB
ajst-6290	88	6	technology	technology	NOUN
ajst-6290	88	7	of	of	ADP
ajst-6290	88	8	crispr	crispr	NOUN
ajst-6290	88	9	-	-	PUNCT
ajst-6290	88	10	cas	cas	NOUN
ajst-6290	88	11	system	system	NOUN
ajst-6290	88	12	has	have	AUX
ajst-6290	88	13	likewise	likewise	ADV
ajst-6290	88	14	become	become	VERB
ajst-6290	88	15	a	a	DET
ajst-6290	88	16	powerful	powerful	ADJ
ajst-6290	88	17	tool	tool	NOUN
ajst-6290	88	18	in	in	ADP
ajst-6290	88	19	synthetic	synthetic	ADJ
ajst-6290	88	20	biology	biology	NOUN
ajst-6290	88	21	to	to	PART
ajst-6290	88	22	precisely	precisely	ADV
ajst-6290	88	23	edit	edit	VERB
ajst-6290	88	24	target	target	NOUN
ajst-6290	88	25	sequences	sequence	NOUN
ajst-6290	88	26	in	in	ADP
ajst-6290	88	27	the	the	DET
ajst-6290	88	28	genome	genome	NOUN
ajst-6290	88	29	and	and	CCONJ
ajst-6290	88	30	has	have	AUX
ajst-6290	88	31	been	be	AUX
ajst-6290	88	32	widely	widely	ADV
ajst-6290	88	33	used	use	VERB
ajst-6290	88	34	in	in	ADP
ajst-6290	88	35	many	many	ADJ
ajst-6290	88	36	fields	field	NOUN
ajst-6290	88	37	[	[	X
ajst-6290	88	38	21	21	NUM
ajst-6290	88	39	]	]	PUNCT
ajst-6290	88	40	.	.	PUNCT
ajst-6290	89	1	3.3	3.3	NUM
ajst-6290	89	2	.	.	PUNCT
ajst-6290	90	1	new	new	ADJ
ajst-6290	90	2	application	application	NOUN
ajst-6290	90	3	areas	area	NOUN
ajst-6290	90	4	of	of	ADP
ajst-6290	90	5	synthetic	synthetic	ADJ
ajst-6290	90	6	biology	biology	NOUN
ajst-6290	90	7	3.3.1	3.3.1	NUM
ajst-6290	90	8	.	.	PUNCT
ajst-6290	90	9	application	application	NOUN
ajst-6290	90	10	of	of	ADP
ajst-6290	90	11	metabolic	metabolic	NOUN
ajst-6290	90	12	engineering	engineering	NOUN
ajst-6290	90	13	and	and	CCONJ
ajst-6290	90	14	biotransformation	biotransformation	NOUN
ajst-6290	90	15	metabolic	metabolic	NOUN
ajst-6290	90	16	engineering	engineering	NOUN
ajst-6290	90	17	and	and	CCONJ
ajst-6290	90	18	biotransformation	biotransformation	NOUN
ajst-6290	90	19	has	have	AUX
ajst-6290	90	20	become	become	VERB
ajst-6290	90	21	a	a	DET
ajst-6290	90	22	hot	hot	ADJ
ajst-6290	90	23	area	area	NOUN
ajst-6290	90	24	in	in	ADP
ajst-6290	90	25	synthetic	synthetic	ADJ
ajst-6290	90	26	biology	biology	NOUN
ajst-6290	90	27	.	.	PUNCT
ajst-6290	91	1	using	use	VERB
ajst-6290	91	2	synthetic	synthetic	ADJ
ajst-6290	91	3	biology	biology	NOUN
ajst-6290	91	4	approaches	approach	NOUN
ajst-6290	91	5	,	,	PUNCT
ajst-6290	91	6	metabolic	metabolic	NOUN
ajst-6290	91	7	pathways	pathway	NOUN
ajst-6290	91	8	can	can	AUX
ajst-6290	91	9	be	be	AUX
ajst-6290	91	10	reconstructed	reconstruct	VERB
ajst-6290	91	11	and	and	CCONJ
ajst-6290	91	12	enzyme	enzyme	NOUN
ajst-6290	91	13	catalysis	catalysis	NOUN
ajst-6290	91	14	can	can	AUX
ajst-6290	91	15	be	be	AUX
ajst-6290	91	16	optimized	optimize	VERB
ajst-6290	91	17	to	to	PART
ajst-6290	91	18	produce	produce	VERB
ajst-6290	91	19	many	many	ADJ
ajst-6290	91	20	novel	novel	ADJ
ajst-6290	91	21	biological	biological	ADJ
ajst-6290	91	22	compounds	compound	NOUN
ajst-6290	91	23	and	and	CCONJ
ajst-6290	91	24	drugs	drug	NOUN
ajst-6290	91	25	.	.	PUNCT
ajst-6290	92	1	amyris	amyris	PROPN
ajst-6290	92	2	is	be	AUX
ajst-6290	92	3	a	a	DET
ajst-6290	92	4	biotechnology	biotechnology	NOUN
ajst-6290	92	5	company	company	NOUN
ajst-6290	92	6	that	that	PRON
ajst-6290	92	7	uses	use	VERB
ajst-6290	92	8	synthetic	synthetic	ADJ
ajst-6290	92	9	biology	biology	NOUN
ajst-6290	92	10	to	to	PART
ajst-6290	92	11	produce	produce	VERB
ajst-6290	92	12	a	a	DET
ajst-6290	92	13	variety	variety	NOUN
ajst-6290	92	14	of	of	ADP
ajst-6290	92	15	high	high	ADJ
ajst-6290	92	16	value	value	NOUN
ajst-6290	92	17	-	-	PUNCT
ajst-6290	92	18	added	add	VERB
ajst-6290	92	19	products	product	NOUN
ajst-6290	92	20	.	.	PUNCT
ajst-6290	93	1	among	among	ADP
ajst-6290	93	2	them	they	PRON
ajst-6290	93	3	is	be	AUX
ajst-6290	93	4	squalane	squalane	NOUN
ajst-6290	93	5	,	,	PUNCT
ajst-6290	93	6	a	a	DET
ajst-6290	93	7	highend	highend	ADJ
ajst-6290	93	8	oil	oil	NOUN
ajst-6290	93	9	used	use	VERB
ajst-6290	93	10	in	in	ADP
ajst-6290	93	11	skin	skin	NOUN
ajst-6290	93	12	care	care	NOUN
ajst-6290	93	13	and	and	CCONJ
ajst-6290	93	14	cosmetics	cosmetic	NOUN
ajst-6290	93	15	,	,	PUNCT
ajst-6290	93	16	which	which	PRON
ajst-6290	93	17	is	be	AUX
ajst-6290	93	18	widely	widely	ADV
ajst-6290	93	19	used	use	VERB
ajst-6290	93	20	for	for	ADP
ajst-6290	93	21	moisturizing	moisturizing	NOUN
ajst-6290	93	22	and	and	CCONJ
ajst-6290	93	23	softening	soften	VERB
ajst-6290	93	24	the	the	DET
ajst-6290	93	25	skin	skin	NOUN
ajst-6290	93	26	.	.	PUNCT
ajst-6290	94	1	traditionally	traditionally	ADV
ajst-6290	94	2	,	,	PUNCT
ajst-6290	94	3	squalane	squalane	NOUN
ajst-6290	94	4	is	be	AUX
ajst-6290	94	5	mainly	mainly	ADV
ajst-6290	94	6	extracted	extract	VERB
ajst-6290	94	7	from	from	ADP
ajst-6290	94	8	shark	shark	NOUN
ajst-6290	94	9	livers	liver	NOUN
ajst-6290	94	10	,	,	PUNCT
ajst-6290	94	11	which	which	PRON
ajst-6290	94	12	not	not	PART
ajst-6290	94	13	only	only	ADV
ajst-6290	94	14	causes	cause	VERB
ajst-6290	94	15	ecological	ecological	ADJ
ajst-6290	94	16	damage	damage	NOUN
ajst-6290	94	17	to	to	ADP
ajst-6290	94	18	sharks	shark	NOUN
ajst-6290	94	19	,	,	PUNCT
ajst-6290	94	20	but	but	CCONJ
ajst-6290	94	21	also	also	ADV
ajst-6290	94	22	makes	make	VERB
ajst-6290	94	23	squalane	squalane	NOUN
ajst-6290	94	24	expensive	expensive	ADJ
ajst-6290	94	25	.	.	PUNCT
ajst-6290	95	1	therefore	therefore	ADV
ajst-6290	95	2	,	,	PUNCT
ajst-6290	95	3	amyris	amyris	PROPN
ajst-6290	95	4	has	have	AUX
ajst-6290	95	5	developed	develop	VERB
ajst-6290	95	6	a	a	DET
ajst-6290	95	7	new	new	ADJ
ajst-6290	95	8	method	method	NOUN
ajst-6290	95	9	for	for	ADP
ajst-6290	95	10	the	the	DET
ajst-6290	95	11	production	production	NOUN
ajst-6290	95	12	of	of	ADP
ajst-6290	95	13	squalane	squalane	NOUN
ajst-6290	95	14	,	,	PUNCT
ajst-6290	95	15	called	call	VERB
ajst-6290	95	16	the	the	DET
ajst-6290	95	17	"	"	PUNCT
ajst-6290	95	18	squalane	squalane	NOUN
ajst-6290	95	19	route	route	NOUN
ajst-6290	95	20	"	"	PUNCT
ajst-6290	96	1	[	[	X
ajst-6290	96	2	22	22	NUM
ajst-6290	96	3	]	]	PUNCT
ajst-6290	96	4	.	.	PUNCT
ajst-6290	97	1	the	the	DET
ajst-6290	97	2	production	production	NOUN
ajst-6290	97	3	process	process	NOUN
ajst-6290	97	4	of	of	ADP
ajst-6290	97	5	this	this	DET
ajst-6290	97	6	route	route	NOUN
ajst-6290	97	7	is	be	AUX
ajst-6290	97	8	based	base	VERB
ajst-6290	97	9	on	on	ADP
ajst-6290	97	10	synthetic	synthetic	ADJ
ajst-6290	97	11	biology	biology	NOUN
ajst-6290	97	12	techniques	technique	NOUN
ajst-6290	97	13	,	,	PUNCT
ajst-6290	97	14	using	use	VERB
ajst-6290	97	15	non	non	ADJ
ajst-6290	97	16	-	-	ADJ
ajst-6290	97	17	pathogenic	pathogenic	ADJ
ajst-6290	97	18	yeast	yeast	NOUN
ajst-6290	97	19	(	(	PUNCT
ajst-6290	97	20	saccharomyces	saccharomyce	NOUN
ajst-6290	97	21	cerevisiae	cerevisiae	NOUN
ajst-6290	97	22	)	)	PUNCT
ajst-6290	97	23	to	to	PART
ajst-6290	97	24	convert	convert	VERB
ajst-6290	97	25	glucose	glucose	NOUN
ajst-6290	97	26	to	to	PART
ajst-6290	97	27	farnesene	farnesene	VERB
ajst-6290	97	28	,	,	PUNCT
ajst-6290	97	29	which	which	PRON
ajst-6290	97	30	is	be	AUX
ajst-6290	97	31	subsequently	subsequently	ADV
ajst-6290	97	32	converted	convert	VERB
ajst-6290	97	33	to	to	ADP
ajst-6290	97	34	squalane	squalane	NOUN
ajst-6290	97	35	.	.	PUNCT
ajst-6290	98	1	this	this	DET
ajst-6290	98	2	process	process	NOUN
ajst-6290	98	3	not	not	PART
ajst-6290	98	4	only	only	ADV
ajst-6290	98	5	avoids	avoid	VERB
ajst-6290	98	6	the	the	DET
ajst-6290	98	7	dependence	dependence	NOUN
ajst-6290	98	8	on	on	ADP
ajst-6290	98	9	sharks	shark	NOUN
ajst-6290	98	10	,	,	PUNCT
ajst-6290	98	11	but	but	CCONJ
ajst-6290	98	12	also	also	ADV
ajst-6290	98	13	enables	enable	VERB
ajst-6290	98	14	the	the	DET
ajst-6290	98	15	large	large	ADJ
ajst-6290	98	16	-	-	PUNCT
ajst-6290	98	17	scale	scale	NOUN
ajst-6290	98	18	production	production	NOUN
ajst-6290	98	19	of	of	ADP
ajst-6290	98	20	high	high	ADJ
ajst-6290	98	21	-	-	PUNCT
ajst-6290	98	22	quality	quality	NOUN
ajst-6290	98	23	squalane	squalane	NOUN
ajst-6290	98	24	,	,	PUNCT
ajst-6290	98	25	thus	thus	ADV
ajst-6290	98	26	reducing	reduce	VERB
ajst-6290	98	27	production	production	NOUN
ajst-6290	98	28	costs	cost	NOUN
ajst-6290	98	29	.	.	PUNCT
ajst-6290	99	1	in	in	ADP
ajst-6290	99	2	addition	addition	NOUN
ajst-6290	99	3	to	to	ADP
ajst-6290	99	4	squalane	squalane	NOUN
ajst-6290	99	5	,	,	PUNCT
ajst-6290	99	6	amyris	amyris	PROPN
ajst-6290	99	7	has	have	AUX
ajst-6290	99	8	produced	produce	VERB
ajst-6290	99	9	a	a	DET
ajst-6290	99	10	variety	variety	NOUN
ajst-6290	99	11	of	of	ADP
ajst-6290	99	12	other	other	ADJ
ajst-6290	99	13	high	high	ADJ
ajst-6290	99	14	value	value	NOUN
ajst-6290	99	15	-	-	PUNCT
ajst-6290	99	16	added	add	VERB
ajst-6290	99	17	chemicals	chemical	NOUN
ajst-6290	99	18	and	and	CCONJ
ajst-6290	99	19	biofuels	biofuel	NOUN
ajst-6290	99	20	through	through	ADP
ajst-6290	99	21	this	this	DET
ajst-6290	99	22	route	route	NOUN
ajst-6290	99	23	,	,	PUNCT
ajst-6290	99	24	which	which	PRON
ajst-6290	99	25	are	be	AUX
ajst-6290	99	26	used	use	VERB
ajst-6290	99	27	in	in	ADP
ajst-6290	99	28	a	a	DET
ajst-6290	99	29	wide	wide	ADJ
ajst-6290	99	30	range	range	NOUN
ajst-6290	99	31	of	of	ADP
ajst-6290	99	32	applications	application	NOUN
ajst-6290	99	33	such	such	ADJ
ajst-6290	99	34	as	as	ADP
ajst-6290	99	35	fragrances	fragrance	NOUN
ajst-6290	99	36	,	,	PUNCT
ajst-6290	99	37	pharmaceuticals	pharmaceutical	NOUN
ajst-6290	99	38	,	,	PUNCT
ajst-6290	99	39	paints	paint	NOUN
ajst-6290	99	40	and	and	CCONJ
ajst-6290	99	41	coatings	coating	NOUN
ajst-6290	99	42	.	.	PUNCT
ajst-6290	100	1	this	this	DET
ajst-6290	100	2	route	route	NOUN
ajst-6290	100	3	has	have	AUX
ajst-6290	100	4	proven	prove	VERB
ajst-6290	100	5	its	its	PRON
ajst-6290	100	6	feasibility	feasibility	NOUN
ajst-6290	100	7	and	and	CCONJ
ajst-6290	100	8	sustainability	sustainability	NOUN
ajst-6290	100	9	in	in	ADP
ajst-6290	100	10	practice	practice	NOUN
ajst-6290	100	11	and	and	CCONJ
ajst-6290	100	12	has	have	AUX
ajst-6290	100	13	become	become	VERB
ajst-6290	100	14	one	one	NUM
ajst-6290	100	15	of	of	ADP
ajst-6290	100	16	the	the	DET
ajst-6290	100	17	representatives	representative	NOUN
ajst-6290	100	18	of	of	ADP
ajst-6290	100	19	new	new	ADJ
ajst-6290	100	20	biotechnologies	biotechnology	NOUN
ajst-6290	100	21	.	.	PUNCT
ajst-6290	101	1	on	on	ADP
ajst-6290	101	2	the	the	DET
ajst-6290	101	3	other	other	ADJ
ajst-6290	101	4	hand	hand	NOUN
ajst-6290	101	5	,	,	PUNCT
ajst-6290	101	6	researchers	researcher	NOUN
ajst-6290	101	7	have	have	AUX
ajst-6290	101	8	succeeded	succeed	VERB
ajst-6290	101	9	in	in	ADP
ajst-6290	101	10	producing	produce	VERB
ajst-6290	101	11	paclitaxel	paclitaxel	ADJ
ajst-6290	101	12	precursors	precursor	NOUN
ajst-6290	101	13	,	,	PUNCT
ajst-6290	101	14	an	an	DET
ajst-6290	101	15	important	important	ADJ
ajst-6290	101	16	anti	anti	ADJ
ajst-6290	101	17	-	-	ADJ
ajst-6290	101	18	cancer	cancer	ADJ
ajst-6290	101	19	drug	drug	NOUN
ajst-6290	101	20	,	,	PUNCT
ajst-6290	101	21	in	in	ADP
ajst-6290	101	22	yields	yield	NOUN
ajst-6290	101	23	of	of	ADP
ajst-6290	101	24	up	up	ADP
ajst-6290	101	25	to	to	PART
ajst-6290	101	26	600	600	NUM
ajst-6290	101	27	mg	mg	NOUN
ajst-6290	101	28	/	/	SYM
ajst-6290	101	29	l	l	NOUN
ajst-6290	101	30	using	use	VERB
ajst-6290	101	31	synthetic	synthetic	ADJ
ajst-6290	101	32	biology	biology	NOUN
ajst-6290	101	33	.	.	PUNCT
ajst-6290	102	1	in	in	ADP
ajst-6290	102	2	addition	addition	NOUN
ajst-6290	102	3	,	,	PUNCT
ajst-6290	102	4	synthetic	synthetic	ADJ
ajst-6290	102	5	biology	biology	NOUN
ajst-6290	102	6	offers	offer	VERB
ajst-6290	102	7	new	new	ADJ
ajst-6290	102	8	ways	way	NOUN
ajst-6290	102	9	to	to	PART
ajst-6290	102	10	produce	produce	VERB
ajst-6290	102	11	environmentally	environmentally	ADV
ajst-6290	102	12	friendly	friendly	ADJ
ajst-6290	102	13	biodiesel	biodiesel	NOUN
ajst-6290	102	14	and	and	CCONJ
ajst-6290	102	15	chemicals	chemical	NOUN
ajst-6290	102	16	[	[	X
ajst-6290	102	17	24	24	NUM
ajst-6290	102	18	-	-	SYM
ajst-6290	102	19	25	25	NUM
ajst-6290	102	20	]	]	PUNCT
ajst-6290	102	21	.	.	PUNCT
ajst-6290	103	1	3.3.2	3.3.2	X
ajst-6290	103	2	.	.	PUNCT
ajst-6290	104	1	research	research	NOUN
ajst-6290	104	2	on	on	ADP
ajst-6290	104	3	synthetic	synthetic	ADJ
ajst-6290	104	4	cells	cell	NOUN
ajst-6290	104	5	and	and	CCONJ
ajst-6290	104	6	biosensors	biosensor	NOUN
ajst-6290	104	7	important	important	ADJ
ajst-6290	104	8	progress	progress	NOUN
ajst-6290	104	9	has	have	AUX
ajst-6290	104	10	also	also	ADV
ajst-6290	104	11	been	be	AUX
ajst-6290	104	12	made	make	VERB
ajst-6290	104	13	in	in	ADP
ajst-6290	104	14	the	the	DET
ajst-6290	104	15	study	study	NOUN
ajst-6290	104	16	of	of	ADP
ajst-6290	104	17	synthetic	synthetic	ADJ
ajst-6290	104	18	cells	cell	NOUN
ajst-6290	104	19	and	and	CCONJ
ajst-6290	104	20	biosensors	biosensor	NOUN
ajst-6290	104	21	.	.	PUNCT
ajst-6290	105	1	by	by	ADP
ajst-6290	105	2	constructing	construct	VERB
ajst-6290	105	3	synthetic	synthetic	ADJ
ajst-6290	105	4	cells	cell	NOUN
ajst-6290	105	5	,	,	PUNCT
ajst-6290	105	6	researchers	researcher	NOUN
ajst-6290	105	7	can	can	AUX
ajst-6290	105	8	deeply	deeply	ADV
ajst-6290	105	9	explore	explore	VERB
ajst-6290	105	10	various	various	ADJ
ajst-6290	105	11	biological	biological	ADJ
ajst-6290	105	12	processes	process	NOUN
ajst-6290	105	13	within	within	ADP
ajst-6290	105	14	cells	cell	NOUN
ajst-6290	105	15	and	and	CCONJ
ajst-6290	105	16	provide	provide	VERB
ajst-6290	105	17	new	new	ADJ
ajst-6290	105	18	ideas	idea	NOUN
ajst-6290	105	19	for	for	ADP
ajst-6290	105	20	future	future	ADJ
ajst-6290	105	21	cell	cell	NOUN
ajst-6290	105	22	engineering	engineering	NOUN
ajst-6290	105	23	and	and	CCONJ
ajst-6290	105	24	medical	medical	ADJ
ajst-6290	105	25	research	research	NOUN
ajst-6290	105	26	.	.	PUNCT
ajst-6290	106	1	for	for	ADP
ajst-6290	106	2	example	example	NOUN
ajst-6290	106	3	,	,	PUNCT
ajst-6290	106	4	synthetic	synthetic	ADJ
ajst-6290	106	5	cells	cell	NOUN
ajst-6290	106	6	can	can	AUX
ajst-6290	106	7	be	be	AUX
ajst-6290	106	8	used	use	VERB
ajst-6290	106	9	to	to	PART
ajst-6290	106	10	produce	produce	VERB
ajst-6290	106	11	drugs	drug	NOUN
ajst-6290	106	12	and	and	CCONJ
ajst-6290	106	13	biochemicals	biochemical	NOUN
ajst-6290	106	14	,	,	PUNCT
ajst-6290	106	15	as	as	ADV
ajst-6290	106	16	well	well	ADV
ajst-6290	106	17	as	as	ADP
ajst-6290	106	18	to	to	PART
ajst-6290	106	19	detect	detect	VERB
ajst-6290	106	20	pollutants	pollutant	NOUN
ajst-6290	106	21	and	and	CCONJ
ajst-6290	106	22	chemicals	chemical	NOUN
ajst-6290	106	23	in	in	ADP
ajst-6290	106	24	the	the	DET
ajst-6290	106	25	environment	environment	NOUN
ajst-6290	106	26	.	.	PUNCT
ajst-6290	107	1	in	in	ADP
ajst-6290	107	2	addition	addition	NOUN
ajst-6290	107	3	,	,	PUNCT
ajst-6290	107	4	biosensors	biosensor	NOUN
ajst-6290	107	5	are	be	AUX
ajst-6290	107	6	new	new	ADJ
ajst-6290	107	7	types	type	NOUN
ajst-6290	107	8	of	of	ADP
ajst-6290	107	9	sensors	sensor	NOUN
ajst-6290	107	10	constructed	construct	VERB
ajst-6290	107	11	by	by	ADP
ajst-6290	107	12	combining	combine	VERB
ajst-6290	107	13	biology	biology	NOUN
ajst-6290	107	14	,	,	PUNCT
ajst-6290	107	15	physics	physics	NOUN
ajst-6290	107	16	,	,	PUNCT
ajst-6290	107	17	chemistry	chemistry	NOUN
ajst-6290	107	18	,	,	PUNCT
ajst-6290	107	19	and	and	CCONJ
ajst-6290	107	20	other	other	ADJ
ajst-6290	107	21	disciplines	discipline	NOUN
ajst-6290	107	22	,	,	PUNCT
ajst-6290	107	23	using	use	VERB
ajst-6290	107	24	the	the	DET
ajst-6290	107	25	properties	property	NOUN
ajst-6290	107	26	of	of	ADP
ajst-6290	107	27	organisms	organism	NOUN
ajst-6290	107	28	that	that	PRON
ajst-6290	107	29	respond	respond	VERB
ajst-6290	107	30	to	to	ADP
ajst-6290	107	31	chemical	chemical	NOUN
ajst-6290	107	32	,	,	PUNCT
ajst-6290	107	33	physical	physical	ADJ
ajst-6290	107	34	,	,	PUNCT
ajst-6290	107	35	and	and	CCONJ
ajst-6290	107	36	biological	biological	ADJ
ajst-6290	107	37	factors	factor	NOUN
ajst-6290	107	38	in	in	ADP
ajst-6290	107	39	the	the	DET
ajst-6290	107	40	environment	environment	NOUN
ajst-6290	107	41	.	.	PUNCT
ajst-6290	108	1	such	such	ADJ
ajst-6290	108	2	sensors	sensor	NOUN
ajst-6290	108	3	have	have	VERB
ajst-6290	108	4	the	the	DET
ajst-6290	108	5	advantages	advantage	NOUN
ajst-6290	108	6	of	of	ADP
ajst-6290	108	7	high	high	ADJ
ajst-6290	108	8	sensitivity	sensitivity	NOUN
ajst-6290	108	9	,	,	PUNCT
ajst-6290	108	10	high	high	ADJ
ajst-6290	108	11	selectivity	selectivity	NOUN
ajst-6290	108	12	,	,	PUNCT
ajst-6290	108	13	and	and	CCONJ
ajst-6290	108	14	fast	fast	ADJ
ajst-6290	108	15	response	response	NOUN
ajst-6290	108	16	,	,	PUNCT
ajst-6290	108	17	and	and	CCONJ
ajst-6290	108	18	can	can	AUX
ajst-6290	108	19	be	be	AUX
ajst-6290	108	20	applied	apply	VERB
ajst-6290	108	21	to	to	ADP
ajst-6290	108	22	environmental	environmental	ADJ
ajst-6290	108	23	monitoring	monitoring	NOUN
ajst-6290	108	24	,	,	PUNCT
ajst-6290	108	25	biomedicine	biomedicine	NOUN
ajst-6290	108	26	,	,	PUNCT
ajst-6290	108	27	and	and	CCONJ
ajst-6290	108	28	other	other	ADJ
ajst-6290	108	29	fields	field	NOUN
ajst-6290	108	30	[	[	PUNCT
ajst-6290	108	31	26	26	NUM
ajst-6290	108	32	-	-	SYM
ajst-6290	108	33	27	27	NUM
ajst-6290	108	34	]	]	PUNCT
ajst-6290	108	35	.	.	PUNCT
ajst-6290	109	1	3.3.3	3.3.3	NUM
ajst-6290	109	2	.	.	PUNCT
ajst-6290	110	1	development	development	NOUN
ajst-6290	110	2	of	of	ADP
ajst-6290	110	3	novel	novel	ADJ
ajst-6290	110	4	biomaterials	biomaterial	NOUN
ajst-6290	110	5	and	and	CCONJ
ajst-6290	110	6	bioenergy	bioenergy	NOUN
ajst-6290	110	7	synthetic	synthetic	NOUN
ajst-6290	110	8	biology	biology	NOUN
ajst-6290	110	9	also	also	ADV
ajst-6290	110	10	provides	provide	VERB
ajst-6290	110	11	new	new	ADJ
ajst-6290	110	12	ideas	idea	NOUN
ajst-6290	110	13	and	and	CCONJ
ajst-6290	110	14	methods	method	NOUN
ajst-6290	110	15	for	for	ADP
ajst-6290	110	16	the	the	DET
ajst-6290	110	17	development	development	NOUN
ajst-6290	110	18	of	of	ADP
ajst-6290	110	19	novel	novel	ADJ
ajst-6290	110	20	biomaterials	biomaterial	NOUN
ajst-6290	110	21	and	and	CCONJ
ajst-6290	110	22	bioenergy	bioenergy	NOUN
ajst-6290	110	23	[	[	X
ajst-6290	110	24	28	28	NUM
ajst-6290	110	25	-	-	SYM
ajst-6290	110	26	29	29	NUM
ajst-6290	110	27	]	]	PUNCT
ajst-6290	110	28	.	.	PUNCT
ajst-6290	111	1	novel	novel	ADJ
ajst-6290	111	2	biomaterials	biomaterial	NOUN
ajst-6290	111	3	with	with	ADP
ajst-6290	111	4	special	special	ADJ
ajst-6290	111	5	properties	property	NOUN
ajst-6290	111	6	can	can	AUX
ajst-6290	111	7	be	be	AUX
ajst-6290	111	8	constructed	construct	VERB
ajst-6290	111	9	using	use	VERB
ajst-6290	111	10	synthetic	synthetic	ADJ
ajst-6290	111	11	biology	biology	NOUN
ajst-6290	111	12	methods	method	NOUN
ajst-6290	111	13	,	,	PUNCT
ajst-6290	111	14	for	for	ADP
ajst-6290	111	15	example	example	NOUN
ajst-6290	111	16	,	,	PUNCT
ajst-6290	111	17	by	by	ADP
ajst-6290	111	18	changing	change	VERB
ajst-6290	111	19	the	the	DET
ajst-6290	111	20	protein	protein	NOUN
ajst-6290	111	21	structure	structure	NOUN
ajst-6290	111	22	,	,	PUNCT
ajst-6290	111	23	materials	material	NOUN
ajst-6290	111	24	with	with	ADP
ajst-6290	111	25	self	self	NOUN
ajst-6290	111	26	-	-	PUNCT
ajst-6290	111	27	healing	healing	NOUN
ajst-6290	111	28	ability	ability	NOUN
ajst-6290	111	29	can	can	AUX
ajst-6290	111	30	be	be	AUX
ajst-6290	111	31	made	make	VERB
ajst-6290	111	32	[	[	X
ajst-6290	111	33	28	28	NUM
ajst-6290	111	34	]	]	PUNCT
ajst-6290	111	35	.	.	PUNCT
ajst-6290	112	1	in	in	ADP
ajst-6290	112	2	addition	addition	NOUN
ajst-6290	112	3	,	,	PUNCT
ajst-6290	112	4	synthetic	synthetic	ADJ
ajst-6290	112	5	biology	biology	NOUN
ajst-6290	112	6	provides	provide	VERB
ajst-6290	112	7	new	new	ADJ
ajst-6290	112	8	ideas	idea	NOUN
ajst-6290	112	9	and	and	CCONJ
ajst-6290	112	10	methods	method	NOUN
ajst-6290	112	11	for	for	ADP
ajst-6290	112	12	the	the	DET
ajst-6290	112	13	development	development	NOUN
ajst-6290	112	14	of	of	ADP
ajst-6290	112	15	bioenergy	bioenergy	NOUN
ajst-6290	112	16	,	,	PUNCT
ajst-6290	112	17	for	for	ADP
ajst-6290	112	18	example	example	NOUN
ajst-6290	112	19	,	,	PUNCT
ajst-6290	112	20	biomass	biomass	NOUN
ajst-6290	112	21	can	can	AUX
ajst-6290	112	22	be	be	AUX
ajst-6290	112	23	converted	convert	VERB
ajst-6290	112	24	into	into	ADP
ajst-6290	112	25	renewable	renewable	ADJ
ajst-6290	112	26	fuels	fuel	NOUN
ajst-6290	112	27	by	by	ADP
ajst-6290	112	28	constructing	construct	VERB
ajst-6290	112	29	new	new	ADJ
ajst-6290	112	30	microorganisms	microorganism	NOUN
ajst-6290	112	31	or	or	CCONJ
ajst-6290	112	32	optimizing	optimize	VERB
ajst-6290	112	33	microbial	microbial	ADJ
ajst-6290	112	34	metabolic	metabolic	NOUN
ajst-6290	112	35	pathways	pathway	NOUN
ajst-6290	113	1	[	[	X
ajst-6290	113	2	29	29	NUM
ajst-6290	113	3	-	-	SYM
ajst-6290	113	4	30	30	NUM
ajst-6290	113	5	]	]	PUNCT
ajst-6290	113	6	.	.	PUNCT
ajst-6290	114	1	currently	currently	ADV
ajst-6290	114	2	,	,	PUNCT
ajst-6290	114	3	synthetic	synthetic	ADJ
ajst-6290	114	4	biology	biology	NOUN
ajst-6290	114	5	has	have	AUX
ajst-6290	114	6	been	be	AUX
ajst-6290	114	7	widely	widely	ADV
ajst-6290	114	8	applied	apply	VERB
ajst-6290	114	9	in	in	ADP
ajst-6290	114	10	many	many	ADJ
ajst-6290	114	11	fields	field	NOUN
ajst-6290	114	12	and	and	CCONJ
ajst-6290	114	13	is	be	AUX
ajst-6290	114	14	continuously	continuously	ADV
ajst-6290	114	15	developing	develop	VERB
ajst-6290	114	16	.	.	PUNCT
ajst-6290	115	1	in	in	ADP
ajst-6290	115	2	the	the	DET
ajst-6290	115	3	future	future	NOUN
ajst-6290	115	4	,	,	PUNCT
ajst-6290	115	5	the	the	DET
ajst-6290	115	6	development	development	NOUN
ajst-6290	115	7	of	of	ADP
ajst-6290	115	8	synthetic	synthetic	ADJ
ajst-6290	115	9	biology	biology	NOUN
ajst-6290	115	10	will	will	AUX
ajst-6290	115	11	face	face	VERB
ajst-6290	115	12	more	more	ADJ
ajst-6290	115	13	challenges	challenge	NOUN
ajst-6290	115	14	and	and	CCONJ
ajst-6290	115	15	opportunities	opportunity	NOUN
ajst-6290	115	16	,	,	PUNCT
ajst-6290	115	17	for	for	ADP
ajst-6290	115	18	example	example	NOUN
ajst-6290	115	19	,	,	PUNCT
ajst-6290	115	20	how	how	SCONJ
ajst-6290	115	21	to	to	PART
ajst-6290	115	22	better	well	ADV
ajst-6290	115	23	control	control	VERB
ajst-6290	115	24	and	and	CCONJ
ajst-6290	115	25	manage	manage	VERB
ajst-6290	115	26	complex	complex	ADJ
ajst-6290	115	27	biological	biological	ADJ
ajst-6290	115	28	systems	system	NOUN
ajst-6290	115	29	and	and	CCONJ
ajst-6290	115	30	how	how	SCONJ
ajst-6290	115	31	to	to	PART
ajst-6290	115	32	cope	cope	VERB
ajst-6290	115	33	with	with	ADP
ajst-6290	115	34	the	the	DET
ajst-6290	115	35	spatial	spatial	ADJ
ajst-6290	115	36	and	and	CCONJ
ajst-6290	115	37	temporal	temporal	ADJ
ajst-6290	115	38	dynamics	dynamic	NOUN
ajst-6290	115	39	of	of	ADP
ajst-6290	115	40	biological	biological	ADJ
ajst-6290	115	41	systems	system	NOUN
ajst-6290	115	42	.	.	PUNCT
ajst-6290	116	1	therefore	therefore	ADV
ajst-6290	116	2	,	,	PUNCT
ajst-6290	116	3	future	future	ADJ
ajst-6290	116	4	research	research	NOUN
ajst-6290	116	5	in	in	ADP
ajst-6290	116	6	synthetic	synthetic	ADJ
ajst-6290	116	7	biology	biology	NOUN
ajst-6290	116	8	will	will	AUX
ajst-6290	116	9	focus	focus	VERB
ajst-6290	116	10	more	more	ADV
ajst-6290	116	11	on	on	ADP
ajst-6290	116	12	interdisciplinary	interdisciplinary	ADJ
ajst-6290	116	13	integration	integration	NOUN
ajst-6290	116	14	and	and	CCONJ
ajst-6290	116	15	innovation	innovation	NOUN
ajst-6290	116	16	to	to	PART
ajst-6290	116	17	build	build	VERB
ajst-6290	116	18	more	more	ADV
ajst-6290	116	19	efficient	efficient	ADJ
ajst-6290	116	20	,	,	PUNCT
ajst-6290	116	21	intelligent	intelligent	ADJ
ajst-6290	116	22	and	and	CCONJ
ajst-6290	116	23	controllable	controllable	ADJ
ajst-6290	116	24	biological	biological	ADJ
ajst-6290	116	25	systems	system	NOUN
ajst-6290	116	26	and	and	CCONJ
ajst-6290	116	27	provide	provide	VERB
ajst-6290	116	28	new	new	ADJ
ajst-6290	116	29	technologies	technology	NOUN
ajst-6290	116	30	and	and	CCONJ
ajst-6290	116	31	solutions	solution	NOUN
ajst-6290	116	32	for	for	ADP
ajst-6290	116	33	the	the	DET
ajst-6290	116	34	sustainable	sustainable	ADJ
ajst-6290	116	35	development	development	NOUN
ajst-6290	116	36	of	of	ADP
ajst-6290	116	37	human	human	ADJ
ajst-6290	116	38	society	society	NOUN
ajst-6290	116	39	.	.	PUNCT
ajst-6290	117	1	3.3.4	3.3.4	X
ajst-6290	117	2	.	.	PUNCT
ajst-6290	117	3	novel	novel	ADJ
ajst-6290	117	4	chemical	chemical	NOUN
ajst-6290	117	5	synthesis	synthesis	NOUN
ajst-6290	117	6	in	in	ADP
ajst-6290	117	7	the	the	DET
ajst-6290	117	8	field	field	NOUN
ajst-6290	117	9	of	of	ADP
ajst-6290	117	10	chemical	chemical	ADJ
ajst-6290	117	11	synthesis	synthesis	NOUN
ajst-6290	117	12	,	,	PUNCT
ajst-6290	117	13	synthetic	synthetic	ADJ
ajst-6290	117	14	biology	biology	NOUN
ajst-6290	117	15	provides	provide	VERB
ajst-6290	117	16	us	we	PRON
ajst-6290	117	17	with	with	ADP
ajst-6290	117	18	a	a	DET
ajst-6290	117	19	green	green	ADJ
ajst-6290	117	20	,	,	PUNCT
ajst-6290	117	21	efficient	efficient	ADJ
ajst-6290	117	22	and	and	CCONJ
ajst-6290	117	23	environmentally	environmentally	ADV
ajst-6290	117	24	friendly	friendly	ADJ
ajst-6290	117	25	method	method	NOUN
ajst-6290	117	26	of	of	ADP
ajst-6290	117	27	biosynthesis	biosynthesis	NOUN
ajst-6290	117	28	,	,	PUNCT
ajst-6290	117	29	i.e.	i.e.	X
ajst-6290	117	30	,	,	PUNCT
ajst-6290	117	31	using	use	VERB
ajst-6290	117	32	microorganisms	microorganism	NOUN
ajst-6290	117	33	or	or	CCONJ
ajst-6290	117	34	cell	cell	NOUN
ajst-6290	117	35	factories	factory	NOUN
ajst-6290	117	36	to	to	PART
ajst-6290	117	37	synthesize	synthesize	VERB
ajst-6290	117	38	chemicals	chemical	NOUN
ajst-6290	117	39	through	through	ADP
ajst-6290	117	40	metabolic	metabolic	NOUN
ajst-6290	117	41	pathways	pathway	NOUN
ajst-6290	117	42	.	.	PUNCT
ajst-6290	118	1	for	for	ADP
ajst-6290	118	2	example	example	NOUN
ajst-6290	118	3	,	,	PUNCT
ajst-6290	118	4	a	a	DET
ajst-6290	118	5	novel	novel	ADJ
ajst-6290	118	6	enzymatic	enzymatic	ADJ
ajst-6290	118	7	route	route	NOUN
ajst-6290	118	8	for	for	ADP
ajst-6290	118	9	pentanediol	pentanediol	NOUN
ajst-6290	118	10	,	,	PUNCT
ajst-6290	118	11	an	an	DET
ajst-6290	118	12	important	important	ADJ
ajst-6290	118	13	organic	organic	ADJ
ajst-6290	118	14	chemical	chemical	NOUN
ajst-6290	118	15	raw	raw	ADJ
ajst-6290	118	16	material	material	NOUN
ajst-6290	118	17	widely	widely	ADV
ajst-6290	118	18	used	use	VERB
ajst-6290	118	19	in	in	ADP
ajst-6290	118	20	polyester	polyester	NOUN
ajst-6290	118	21	,	,	PUNCT
ajst-6290	118	22	polyurethane	polyurethane	NOUN
ajst-6290	118	23	,	,	PUNCT
ajst-6290	118	24	solvents	solvent	NOUN
ajst-6290	118	25	,	,	PUNCT
ajst-6290	118	26	etc	etc	X
ajst-6290	118	27	.	.	X
ajst-6290	118	28	traditional	traditional	ADJ
ajst-6290	118	29	methods	method	NOUN
ajst-6290	118	30	of	of	ADP
ajst-6290	118	31	pentanediol	pentanediol	PROPN
ajst-6290	118	32	synthesis	synthesis	NOUN
ajst-6290	118	33	often	often	ADV
ajst-6290	118	34	require	require	VERB
ajst-6290	118	35	the	the	DET
ajst-6290	118	36	use	use	NOUN
ajst-6290	118	37	of	of	ADP
ajst-6290	118	38	high	high	ADJ
ajst-6290	118	39	temperature	temperature	NOUN
ajst-6290	118	40	,	,	PUNCT
ajst-6290	118	41	high	high	ADJ
ajst-6290	118	42	pressure	pressure	NOUN
ajst-6290	118	43	,	,	PUNCT
ajst-6290	118	44	and	and	CCONJ
ajst-6290	118	45	toxic	toxic	ADJ
ajst-6290	118	46	chemicals	chemical	NOUN
ajst-6290	118	47	,	,	PUNCT
ajst-6290	118	48	which	which	PRON
ajst-6290	118	49	not	not	PART
ajst-6290	118	50	only	only	ADV
ajst-6290	118	51	cause	cause	VERB
ajst-6290	118	52	serious	serious	ADJ
ajst-6290	118	53	environmental	environmental	ADJ
ajst-6290	118	54	pollution	pollution	NOUN
ajst-6290	118	55	,	,	PUNCT
ajst-6290	118	56	but	but	CCONJ
ajst-6290	118	57	98	98	NUM
ajst-6290	118	58	also	also	ADV
ajst-6290	118	59	make	make	VERB
ajst-6290	118	60	it	it	PRON
ajst-6290	118	61	difficult	difficult	ADJ
ajst-6290	118	62	to	to	PART
ajst-6290	118	63	control	control	VERB
ajst-6290	118	64	the	the	DET
ajst-6290	118	65	quality	quality	NOUN
ajst-6290	118	66	of	of	ADP
ajst-6290	118	67	the	the	DET
ajst-6290	118	68	products	product	NOUN
ajst-6290	118	69	.	.	PUNCT
ajst-6290	119	1	compared	compare	VERB
ajst-6290	119	2	with	with	ADP
ajst-6290	119	3	this	this	PRON
ajst-6290	119	4	,	,	PUNCT
ajst-6290	119	5	the	the	DET
ajst-6290	119	6	synthesis	synthesis	NOUN
ajst-6290	119	7	of	of	ADP
ajst-6290	119	8	pentanediol	pentanediol	NOUN
ajst-6290	119	9	using	use	VERB
ajst-6290	119	10	synthetic	synthetic	ADJ
ajst-6290	119	11	biology	biology	NOUN
ajst-6290	119	12	technology	technology	NOUN
ajst-6290	119	13	can	can	AUX
ajst-6290	119	14	not	not	PART
ajst-6290	119	15	only	only	ADV
ajst-6290	119	16	avoid	avoid	VERB
ajst-6290	119	17	the	the	DET
ajst-6290	119	18	above	above	ADJ
ajst-6290	119	19	disadvantages	disadvantage	NOUN
ajst-6290	119	20	,	,	PUNCT
ajst-6290	119	21	but	but	CCONJ
ajst-6290	119	22	also	also	ADV
ajst-6290	119	23	be	be	AUX
ajst-6290	119	24	more	more	ADV
ajst-6290	119	25	environmentally	environmentally	ADV
ajst-6290	119	26	friendly	friendly	ADJ
ajst-6290	119	27	,	,	PUNCT
ajst-6290	119	28	efficient	efficient	ADJ
ajst-6290	119	29	and	and	CCONJ
ajst-6290	119	30	controllable	controllable	ADJ
ajst-6290	119	31	.	.	PUNCT
ajst-6290	120	1	in	in	ADP
ajst-6290	120	2	the	the	DET
ajst-6290	120	3	enzymatic	enzymatic	ADJ
ajst-6290	120	4	route	route	NOUN
ajst-6290	120	5	of	of	ADP
ajst-6290	120	6	pentanediol	pentanediol	NOUN
ajst-6290	120	7	,	,	PUNCT
ajst-6290	120	8	substrate	substrate	NOUN
ajst-6290	120	9	dehydrogenase	dehydrogenase	NOUN
ajst-6290	120	10	and	and	CCONJ
ajst-6290	120	11	reductase	reductase	NOUN
ajst-6290	120	12	are	be	AUX
ajst-6290	120	13	the	the	DET
ajst-6290	120	14	key	key	ADJ
ajst-6290	120	15	catalytic	catalytic	ADJ
ajst-6290	120	16	enzymes	enzyme	NOUN
ajst-6290	120	17	.	.	PUNCT
ajst-6290	121	1	by	by	ADP
ajst-6290	121	2	genetically	genetically	ADV
ajst-6290	121	3	engineering	engineering	NOUN
ajst-6290	121	4	and	and	CCONJ
ajst-6290	121	5	optimizing	optimize	VERB
ajst-6290	121	6	the	the	DET
ajst-6290	121	7	substrate	substrate	NOUN
ajst-6290	121	8	dehydrogenase	dehydrogenase	NOUN
ajst-6290	121	9	and	and	CCONJ
ajst-6290	121	10	reductase	reductase	NOUN
ajst-6290	121	11	,	,	PUNCT
ajst-6290	121	12	the	the	DET
ajst-6290	121	13	catalytic	catalytic	ADJ
ajst-6290	121	14	efficiency	efficiency	NOUN
ajst-6290	121	15	,	,	PUNCT
ajst-6290	121	16	stability	stability	NOUN
ajst-6290	121	17	and	and	CCONJ
ajst-6290	121	18	selectivity	selectivity	NOUN
ajst-6290	121	19	of	of	ADP
ajst-6290	121	20	the	the	DET
ajst-6290	121	21	enzymes	enzyme	NOUN
ajst-6290	121	22	can	can	AUX
ajst-6290	121	23	be	be	AUX
ajst-6290	121	24	improved	improve	VERB
ajst-6290	121	25	,	,	PUNCT
ajst-6290	121	26	thus	thus	ADV
ajst-6290	121	27	enhancing	enhance	VERB
ajst-6290	121	28	the	the	DET
ajst-6290	121	29	yield	yield	NOUN
ajst-6290	121	30	and	and	CCONJ
ajst-6290	121	31	quality	quality	NOUN
ajst-6290	121	32	of	of	ADP
ajst-6290	121	33	pentanediol	pentanediol	NOUN
ajst-6290	121	34	.	.	PUNCT
ajst-6290	122	1	in	in	ADP
ajst-6290	122	2	addition	addition	NOUN
ajst-6290	122	3	,	,	PUNCT
ajst-6290	122	4	the	the	DET
ajst-6290	122	5	metabolic	metabolic	NOUN
ajst-6290	122	6	pathways	pathway	NOUN
ajst-6290	122	7	of	of	ADP
ajst-6290	122	8	microorganisms	microorganism	NOUN
ajst-6290	122	9	can	can	AUX
ajst-6290	122	10	be	be	AUX
ajst-6290	122	11	optimized	optimize	VERB
ajst-6290	122	12	by	by	ADP
ajst-6290	122	13	means	mean	NOUN
ajst-6290	122	14	of	of	ADP
ajst-6290	122	15	systems	system	NOUN
ajst-6290	122	16	biology	biology	NOUN
ajst-6290	122	17	and	and	CCONJ
ajst-6290	122	18	metabolic	metabolic	NOUN
ajst-6290	122	19	engineering	engineering	NOUN
ajst-6290	122	20	to	to	PART
ajst-6290	122	21	improve	improve	VERB
ajst-6290	122	22	substrate	substrate	NOUN
ajst-6290	122	23	utilization	utilization	NOUN
ajst-6290	122	24	and	and	CCONJ
ajst-6290	122	25	further	far	ADV
ajst-6290	122	26	increase	increase	VERB
ajst-6290	122	27	the	the	DET
ajst-6290	122	28	yield	yield	NOUN
ajst-6290	122	29	of	of	ADP
ajst-6290	122	30	pentanediol	pentanediol	NOUN
ajst-6290	122	31	[	[	X
ajst-6290	122	32	23	23	NUM
ajst-6290	122	33	]	]	PUNCT
ajst-6290	122	34	.	.	PUNCT
ajst-6290	123	1	in	in	ADP
ajst-6290	123	2	the	the	DET
ajst-6290	123	3	future	future	NOUN
ajst-6290	123	4	,	,	PUNCT
ajst-6290	123	5	with	with	ADP
ajst-6290	123	6	the	the	DET
ajst-6290	123	7	continuous	continuous	ADJ
ajst-6290	123	8	development	development	NOUN
ajst-6290	123	9	and	and	CCONJ
ajst-6290	123	10	improvement	improvement	NOUN
ajst-6290	123	11	of	of	ADP
ajst-6290	123	12	synthetic	synthetic	ADJ
ajst-6290	123	13	biology	biology	NOUN
ajst-6290	123	14	technology	technology	NOUN
ajst-6290	123	15	,	,	PUNCT
ajst-6290	123	16	the	the	DET
ajst-6290	123	17	production	production	NOUN
ajst-6290	123	18	efficiency	efficiency	NOUN
ajst-6290	123	19	and	and	CCONJ
ajst-6290	123	20	controllability	controllability	NOUN
ajst-6290	123	21	of	of	ADP
ajst-6290	123	22	novel	novel	ADJ
ajst-6290	123	23	chemicals	chemical	NOUN
ajst-6290	123	24	will	will	AUX
ajst-6290	123	25	continue	continue	VERB
ajst-6290	123	26	to	to	PART
ajst-6290	123	27	improve	improve	VERB
ajst-6290	123	28	,	,	PUNCT
ajst-6290	123	29	providing	provide	VERB
ajst-6290	123	30	better	well	ADJ
ajst-6290	123	31	options	option	NOUN
ajst-6290	123	32	for	for	ADP
ajst-6290	123	33	industrial	industrial	ADJ
ajst-6290	123	34	production	production	NOUN
ajst-6290	123	35	and	and	CCONJ
ajst-6290	123	36	environmental	environmental	ADJ
ajst-6290	123	37	protection	protection	NOUN
ajst-6290	123	38	,	,	PUNCT
ajst-6290	123	39	and	and	CCONJ
ajst-6290	123	40	various	various	ADJ
ajst-6290	123	41	innovative	innovative	ADJ
ajst-6290	123	42	applications	application	NOUN
ajst-6290	123	43	and	and	CCONJ
ajst-6290	123	44	research	research	NOUN
ajst-6290	123	45	directions	direction	NOUN
ajst-6290	123	46	will	will	AUX
ajst-6290	123	47	continue	continue	VERB
ajst-6290	123	48	to	to	PART
ajst-6290	123	49	emerge	emerge	VERB
ajst-6290	123	50	in	in	ADP
ajst-6290	123	51	the	the	DET
ajst-6290	123	52	field	field	NOUN
ajst-6290	123	53	of	of	ADP
ajst-6290	123	54	novel	novel	ADJ
ajst-6290	123	55	chemical	chemical	NOUN
ajst-6290	123	56	synthesis	synthesis	NOUN
ajst-6290	123	57	.	.	PUNCT
ajst-6290	124	1	4	4	X
ajst-6290	124	2	.	.	NOUN
ajst-6290	124	3	ethical	ethical	ADJ
ajst-6290	124	4	and	and	CCONJ
ajst-6290	124	5	social	social	ADJ
ajst-6290	124	6	implications	implication	NOUN
ajst-6290	124	7	of	of	ADP
ajst-6290	124	8	synthetic	synthetic	ADJ
ajst-6290	124	9	biology	biology	NOUN
ajst-6290	124	10	synthetic	synthetic	ADJ
ajst-6290	124	11	biology	biology	NOUN
ajst-6290	124	12	is	be	AUX
ajst-6290	124	13	an	an	DET
ajst-6290	124	14	emerging	emerge	VERB
ajst-6290	124	15	discipline	discipline	NOUN
ajst-6290	124	16	full	full	ADJ
ajst-6290	124	17	of	of	ADP
ajst-6290	124	18	challenges	challenge	NOUN
ajst-6290	124	19	and	and	CCONJ
ajst-6290	124	20	opportunities	opportunity	NOUN
ajst-6290	124	21	.	.	PUNCT
ajst-6290	125	1	in	in	ADP
ajst-6290	125	2	addition	addition	NOUN
ajst-6290	125	3	to	to	ADP
ajst-6290	125	4	technical	technical	ADJ
ajst-6290	125	5	challenges	challenge	NOUN
ajst-6290	125	6	,	,	PUNCT
ajst-6290	125	7	the	the	DET
ajst-6290	125	8	development	development	NOUN
ajst-6290	125	9	of	of	ADP
ajst-6290	125	10	synthetic	synthetic	ADJ
ajst-6290	125	11	biology	biology	NOUN
ajst-6290	125	12	involves	involve	VERB
ajst-6290	125	13	a	a	DET
ajst-6290	125	14	range	range	NOUN
ajst-6290	125	15	of	of	ADP
ajst-6290	125	16	ethical	ethical	ADJ
ajst-6290	125	17	and	and	CCONJ
ajst-6290	125	18	societal	societal	ADJ
ajst-6290	125	19	issues	issue	NOUN
ajst-6290	125	20	,	,	PUNCT
ajst-6290	125	21	including	include	VERB
ajst-6290	125	22	potential	potential	ADJ
ajst-6290	125	23	dangers	danger	NOUN
ajst-6290	125	24	and	and	CCONJ
ajst-6290	125	25	safety	safety	NOUN
ajst-6290	125	26	concerns	concern	NOUN
ajst-6290	125	27	,	,	PUNCT
ajst-6290	125	28	intellectual	intellectual	ADJ
ajst-6290	125	29	property	property	NOUN
ajst-6290	125	30	rights	right	NOUN
ajst-6290	125	31	and	and	CCONJ
ajst-6290	125	32	commercialization	commercialization	NOUN
ajst-6290	125	33	,	,	PUNCT
ajst-6290	125	34	social	social	ADJ
ajst-6290	125	35	and	and	CCONJ
ajst-6290	125	36	cultural	cultural	ADJ
ajst-6290	125	37	implications	implication	NOUN
ajst-6290	125	38	,	,	PUNCT
ajst-6290	125	39	and	and	CCONJ
ajst-6290	125	40	policy	policy	NOUN
ajst-6290	125	41	and	and	CCONJ
ajst-6290	125	42	regulatory	regulatory	ADJ
ajst-6290	125	43	developments	development	NOUN
ajst-6290	125	44	.	.	PUNCT
ajst-6290	126	1	these	these	DET
ajst-6290	126	2	issues	issue	NOUN
ajst-6290	126	3	need	need	VERB
ajst-6290	126	4	to	to	PART
ajst-6290	126	5	be	be	AUX
ajst-6290	126	6	carefully	carefully	ADV
ajst-6290	126	7	considered	consider	VERB
ajst-6290	126	8	and	and	CCONJ
ajst-6290	126	9	explored	explore	VERB
ajst-6290	126	10	in	in	ADP
ajst-6290	126	11	order	order	NOUN
ajst-6290	126	12	to	to	PART
ajst-6290	126	13	ensure	ensure	VERB
ajst-6290	126	14	that	that	SCONJ
ajst-6290	126	15	the	the	DET
ajst-6290	126	16	development	development	NOUN
ajst-6290	126	17	and	and	CCONJ
ajst-6290	126	18	application	application	NOUN
ajst-6290	126	19	of	of	ADP
ajst-6290	126	20	synthetic	synthetic	ADJ
ajst-6290	126	21	biology	biology	NOUN
ajst-6290	126	22	can	can	AUX
ajst-6290	126	23	better	well	ADV
ajst-6290	126	24	benefit	benefit	VERB
ajst-6290	126	25	human	human	ADJ
ajst-6290	126	26	society	society	NOUN
ajst-6290	126	27	.	.	PUNCT
ajst-6290	127	1	4.1	4.1	NUM
ajst-6290	127	2	.	.	PUNCT
ajst-6290	127	3	potential	potential	ADJ
ajst-6290	127	4	dangers	danger	NOUN
ajst-6290	127	5	and	and	CCONJ
ajst-6290	127	6	safety	safety	NOUN
ajst-6290	127	7	issues	issue	NOUN
ajst-6290	127	8	of	of	ADP
ajst-6290	127	9	synthetic	synthetic	ADJ
ajst-6290	127	10	biology	biology	NOUN
ajst-6290	127	11	the	the	DET
ajst-6290	127	12	application	application	NOUN
ajst-6290	127	13	of	of	ADP
ajst-6290	127	14	synthetic	synthetic	ADJ
ajst-6290	127	15	biology	biology	NOUN
ajst-6290	127	16	technology	technology	NOUN
ajst-6290	127	17	may	may	AUX
ajst-6290	127	18	bring	bring	VERB
ajst-6290	127	19	potential	potential	ADJ
ajst-6290	127	20	dangers	danger	NOUN
ajst-6290	127	21	,	,	PUNCT
ajst-6290	127	22	such	such	ADJ
ajst-6290	127	23	as	as	ADP
ajst-6290	127	24	synthesizing	synthesize	VERB
ajst-6290	127	25	pathogens	pathogen	NOUN
ajst-6290	127	26	or	or	CCONJ
ajst-6290	127	27	harmful	harmful	ADJ
ajst-6290	127	28	organisms	organism	NOUN
ajst-6290	127	29	,	,	PUNCT
ajst-6290	127	30	or	or	CCONJ
ajst-6290	127	31	releasing	release	VERB
ajst-6290	127	32	harmful	harmful	ADJ
ajst-6290	127	33	substances	substance	NOUN
ajst-6290	127	34	into	into	ADP
ajst-6290	127	35	the	the	DET
ajst-6290	127	36	environment	environment	NOUN
ajst-6290	127	37	.	.	PUNCT
ajst-6290	128	1	these	these	PRON
ajst-6290	128	2	may	may	AUX
ajst-6290	128	3	pose	pose	VERB
ajst-6290	128	4	hazards	hazard	NOUN
ajst-6290	128	5	to	to	ADP
ajst-6290	128	6	humans	human	NOUN
ajst-6290	128	7	,	,	PUNCT
ajst-6290	128	8	animals	animal	NOUN
ajst-6290	128	9	,	,	PUNCT
ajst-6290	128	10	and	and	CCONJ
ajst-6290	128	11	the	the	DET
ajst-6290	128	12	environment	environment	NOUN
ajst-6290	128	13	,	,	PUNCT
ajst-6290	128	14	and	and	CCONJ
ajst-6290	128	15	therefore	therefore	ADV
ajst-6290	128	16	,	,	PUNCT
ajst-6290	128	17	safety	safety	NOUN
ajst-6290	128	18	measures	measure	NOUN
ajst-6290	128	19	such	such	ADJ
ajst-6290	128	20	as	as	ADP
ajst-6290	128	21	appropriate	appropriate	ADJ
ajst-6290	128	22	biosafety	biosafety	NOUN
ajst-6290	128	23	laboratories	laboratory	NOUN
ajst-6290	128	24	must	must	AUX
ajst-6290	128	25	be	be	AUX
ajst-6290	128	26	established	establish	VERB
ajst-6290	128	27	to	to	PART
ajst-6290	128	28	ensure	ensure	VERB
ajst-6290	128	29	that	that	SCONJ
ajst-6290	128	30	research	research	NOUN
ajst-6290	128	31	and	and	CCONJ
ajst-6290	128	32	applications	application	NOUN
ajst-6290	128	33	of	of	ADP
ajst-6290	128	34	synthetic	synthetic	ADJ
ajst-6290	128	35	biology	biology	NOUN
ajst-6290	128	36	do	do	AUX
ajst-6290	128	37	not	not	PART
ajst-6290	128	38	pose	pose	VERB
ajst-6290	128	39	potential	potential	ADJ
ajst-6290	128	40	threats	threat	NOUN
ajst-6290	128	41	to	to	ADP
ajst-6290	128	42	humans	human	NOUN
ajst-6290	128	43	and	and	CCONJ
ajst-6290	128	44	the	the	DET
ajst-6290	128	45	environment	environment	NOUN
ajst-6290	128	46	.	.	PUNCT
ajst-6290	129	1	in	in	ADP
ajst-6290	129	2	addition	addition	NOUN
ajst-6290	129	3	,	,	PUNCT
ajst-6290	129	4	the	the	DET
ajst-6290	129	5	rapid	rapid	ADJ
ajst-6290	129	6	technological	technological	ADJ
ajst-6290	129	7	development	development	NOUN
ajst-6290	129	8	of	of	ADP
ajst-6290	129	9	synthetic	synthetic	ADJ
ajst-6290	129	10	biology	biology	NOUN
ajst-6290	129	11	makes	make	VERB
ajst-6290	129	12	it	it	PRON
ajst-6290	129	13	difficult	difficult	ADJ
ajst-6290	129	14	to	to	PART
ajst-6290	129	15	assess	assess	VERB
ajst-6290	129	16	the	the	DET
ajst-6290	129	17	risk	risk	NOUN
ajst-6290	129	18	of	of	ADP
ajst-6290	129	19	its	its	PRON
ajst-6290	129	20	application	application	NOUN
ajst-6290	129	21	,	,	PUNCT
ajst-6290	129	22	and	and	CCONJ
ajst-6290	129	23	therefore	therefore	ADV
ajst-6290	129	24	there	there	PRON
ajst-6290	129	25	is	be	VERB
ajst-6290	129	26	a	a	DET
ajst-6290	129	27	need	need	NOUN
ajst-6290	129	28	to	to	PART
ajst-6290	129	29	strengthen	strengthen	VERB
ajst-6290	129	30	the	the	DET
ajst-6290	129	31	related	related	ADJ
ajst-6290	129	32	risk	risk	NOUN
ajst-6290	129	33	assessment	assessment	NOUN
ajst-6290	129	34	and	and	CCONJ
ajst-6290	129	35	management	management	NOUN
ajst-6290	129	36	.	.	PUNCT
ajst-6290	130	1	at	at	ADP
ajst-6290	130	2	the	the	DET
ajst-6290	130	3	same	same	ADJ
ajst-6290	130	4	time	time	NOUN
ajst-6290	130	5	,	,	PUNCT
ajst-6290	130	6	a	a	DET
ajst-6290	130	7	global	global	ADJ
ajst-6290	130	8	regulatory	regulatory	ADJ
ajst-6290	130	9	system	system	NOUN
ajst-6290	130	10	and	and	CCONJ
ajst-6290	130	11	norms	norm	NOUN
ajst-6290	130	12	need	need	VERB
ajst-6290	130	13	to	to	PART
ajst-6290	130	14	be	be	AUX
ajst-6290	130	15	established	establish	VERB
ajst-6290	130	16	to	to	PART
ajst-6290	130	17	ensure	ensure	VERB
ajst-6290	130	18	the	the	DET
ajst-6290	130	19	safety	safety	NOUN
ajst-6290	130	20	and	and	CCONJ
ajst-6290	130	21	sustainability	sustainability	NOUN
ajst-6290	130	22	of	of	ADP
ajst-6290	130	23	synthetic	synthetic	ADJ
ajst-6290	130	24	biology	biology	NOUN
ajst-6290	130	25	.	.	PUNCT
ajst-6290	131	1	4.2	4.2	NUM
ajst-6290	131	2	.	.	PUNCT
ajst-6290	132	1	ethical	ethical	ADJ
ajst-6290	132	2	and	and	CCONJ
ajst-6290	132	3	social	social	ADJ
ajst-6290	132	4	issues	issue	NOUN
ajst-6290	132	5	of	of	ADP
ajst-6290	132	6	synthetic	synthetic	ADJ
ajst-6290	132	7	biology	biology	NOUN
ajst-6290	132	8	the	the	DET
ajst-6290	132	9	rapid	rapid	ADJ
ajst-6290	132	10	development	development	NOUN
ajst-6290	132	11	and	and	CCONJ
ajst-6290	132	12	application	application	NOUN
ajst-6290	132	13	of	of	ADP
ajst-6290	132	14	synthetic	synthetic	ADJ
ajst-6290	132	15	biology	biology	NOUN
ajst-6290	132	16	has	have	AUX
ajst-6290	132	17	also	also	ADV
ajst-6290	132	18	raised	raise	VERB
ajst-6290	132	19	a	a	DET
ajst-6290	132	20	series	series	NOUN
ajst-6290	132	21	of	of	ADP
ajst-6290	132	22	ethical	ethical	ADJ
ajst-6290	132	23	and	and	CCONJ
ajst-6290	132	24	social	social	ADJ
ajst-6290	132	25	issues	issue	NOUN
ajst-6290	132	26	.	.	PUNCT
ajst-6290	133	1	among	among	ADP
ajst-6290	133	2	the	the	DET
ajst-6290	133	3	major	major	ADJ
ajst-6290	133	4	issues	issue	NOUN
ajst-6290	133	5	are	be	AUX
ajst-6290	133	6	intellectual	intellectual	ADJ
ajst-6290	133	7	property	property	NOUN
ajst-6290	133	8	rights	right	NOUN
ajst-6290	133	9	and	and	CCONJ
ajst-6290	133	10	commercialization	commercialization	NOUN
ajst-6290	133	11	.	.	PUNCT
ajst-6290	134	1	with	with	ADP
ajst-6290	134	2	the	the	DET
ajst-6290	134	3	commercialization	commercialization	NOUN
ajst-6290	134	4	and	and	CCONJ
ajst-6290	134	5	industrialization	industrialization	NOUN
ajst-6290	134	6	of	of	ADP
ajst-6290	134	7	synthetic	synthetic	ADJ
ajst-6290	134	8	biology	biology	NOUN
ajst-6290	134	9	technologies	technology	NOUN
ajst-6290	134	10	,	,	PUNCT
ajst-6290	134	11	the	the	DET
ajst-6290	134	12	associated	associated	ADJ
ajst-6290	134	13	intellectual	intellectual	ADJ
ajst-6290	134	14	property	property	NOUN
ajst-6290	134	15	rights	right	NOUN
ajst-6290	134	16	and	and	CCONJ
ajst-6290	134	17	business	business	NOUN
ajst-6290	134	18	models	model	NOUN
ajst-6290	134	19	have	have	AUX
ajst-6290	134	20	become	become	VERB
ajst-6290	134	21	the	the	DET
ajst-6290	134	22	focus	focus	NOUN
ajst-6290	134	23	of	of	ADP
ajst-6290	134	24	discussion	discussion	NOUN
ajst-6290	134	25	among	among	ADP
ajst-6290	134	26	researchers	researcher	NOUN
ajst-6290	134	27	and	and	CCONJ
ajst-6290	134	28	companies	company	NOUN
ajst-6290	134	29	.	.	PUNCT
ajst-6290	135	1	a	a	DET
ajst-6290	135	2	portion	portion	NOUN
ajst-6290	135	3	of	of	ADP
ajst-6290	135	4	the	the	DET
ajst-6290	135	5	population	population	NOUN
ajst-6290	135	6	is	be	AUX
ajst-6290	135	7	concerned	concern	VERB
ajst-6290	135	8	that	that	SCONJ
ajst-6290	135	9	competing	compete	VERB
ajst-6290	135	10	intellectual	intellectual	ADJ
ajst-6290	135	11	property	property	NOUN
ajst-6290	135	12	rights	right	NOUN
ajst-6290	135	13	and	and	CCONJ
ajst-6290	135	14	business	business	NOUN
ajst-6290	135	15	models	model	NOUN
ajst-6290	135	16	may	may	AUX
ajst-6290	135	17	result	result	VERB
ajst-6290	135	18	in	in	ADP
ajst-6290	135	19	some	some	DET
ajst-6290	135	20	research	research	NOUN
ajst-6290	135	21	results	result	NOUN
ajst-6290	135	22	not	not	PART
ajst-6290	135	23	being	be	AUX
ajst-6290	135	24	adequately	adequately	ADV
ajst-6290	135	25	shared	share	VERB
ajst-6290	135	26	and	and	CCONJ
ajst-6290	135	27	utilized	utilize	VERB
ajst-6290	135	28	,	,	PUNCT
ajst-6290	135	29	thus	thus	ADV
ajst-6290	135	30	hindering	hinder	VERB
ajst-6290	135	31	the	the	DET
ajst-6290	135	32	development	development	NOUN
ajst-6290	135	33	and	and	CCONJ
ajst-6290	135	34	application	application	NOUN
ajst-6290	135	35	of	of	ADP
ajst-6290	135	36	synthetic	synthetic	ADJ
ajst-6290	135	37	biology	biology	NOUN
ajst-6290	135	38	.	.	PUNCT
ajst-6290	136	1	in	in	ADP
ajst-6290	136	2	addition	addition	NOUN
ajst-6290	136	3	,	,	PUNCT
ajst-6290	136	4	the	the	DET
ajst-6290	136	5	development	development	NOUN
ajst-6290	136	6	of	of	ADP
ajst-6290	136	7	synthetic	synthetic	ADJ
ajst-6290	136	8	biology	biology	NOUN
ajst-6290	136	9	may	may	AUX
ajst-6290	136	10	also	also	ADV
ajst-6290	136	11	have	have	VERB
ajst-6290	136	12	social	social	ADJ
ajst-6290	136	13	and	and	CCONJ
ajst-6290	136	14	cultural	cultural	ADJ
ajst-6290	136	15	implications	implication	NOUN
ajst-6290	136	16	,	,	PUNCT
ajst-6290	136	17	such	such	ADJ
ajst-6290	136	18	as	as	ADP
ajst-6290	136	19	changes	change	NOUN
ajst-6290	136	20	to	to	ADP
ajst-6290	136	21	the	the	DET
ajst-6290	136	22	environment	environment	NOUN
ajst-6290	136	23	,	,	PUNCT
ajst-6290	136	24	food	food	NOUN
ajst-6290	136	25	,	,	PUNCT
ajst-6290	136	26	and	and	CCONJ
ajst-6290	136	27	medicine	medicine	NOUN
ajst-6290	136	28	,	,	PUNCT
ajst-6290	136	29	and	and	CCONJ
ajst-6290	136	30	may	may	AUX
ajst-6290	136	31	also	also	ADV
ajst-6290	136	32	cause	cause	VERB
ajst-6290	136	33	ethical	ethical	ADJ
ajst-6290	136	34	,	,	PUNCT
ajst-6290	136	35	cultural	cultural	ADJ
ajst-6290	136	36	,	,	PUNCT
ajst-6290	136	37	and	and	CCONJ
ajst-6290	136	38	religious	religious	ADJ
ajst-6290	136	39	controversies	controversy	NOUN
ajst-6290	136	40	.	.	PUNCT
ajst-6290	137	1	for	for	ADP
ajst-6290	137	2	example	example	NOUN
ajst-6290	137	3	,	,	PUNCT
ajst-6290	137	4	synthetic	synthetic	ADJ
ajst-6290	137	5	biology	biology	NOUN
ajst-6290	137	6	may	may	AUX
ajst-6290	137	7	be	be	AUX
ajst-6290	137	8	used	use	VERB
ajst-6290	137	9	to	to	PART
ajst-6290	137	10	produce	produce	VERB
ajst-6290	137	11	large	large	ADJ
ajst-6290	137	12	quantities	quantity	NOUN
ajst-6290	137	13	of	of	ADP
ajst-6290	137	14	human	human	ADJ
ajst-6290	137	15	tissues	tissue	NOUN
ajst-6290	137	16	and	and	CCONJ
ajst-6290	137	17	organs	organ	NOUN
ajst-6290	137	18	,	,	PUNCT
ajst-6290	137	19	which	which	PRON
ajst-6290	137	20	is	be	AUX
ajst-6290	137	21	promising	promise	VERB
ajst-6290	137	22	for	for	ADP
ajst-6290	137	23	the	the	DET
ajst-6290	137	24	medical	medical	ADJ
ajst-6290	137	25	field	field	NOUN
ajst-6290	137	26	,	,	PUNCT
ajst-6290	137	27	but	but	CCONJ
ajst-6290	137	28	also	also	ADV
ajst-6290	137	29	raises	raise	VERB
ajst-6290	137	30	some	some	DET
ajst-6290	137	31	moral	moral	ADJ
ajst-6290	137	32	and	and	CCONJ
ajst-6290	137	33	ethical	ethical	ADJ
ajst-6290	137	34	concerns	concern	NOUN
ajst-6290	137	35	.	.	PUNCT
ajst-6290	138	1	in	in	ADP
ajst-6290	138	2	addition	addition	NOUN
ajst-6290	138	3	,	,	PUNCT
ajst-6290	138	4	some	some	PRON
ajst-6290	138	5	are	be	AUX
ajst-6290	138	6	concerned	concerned	ADJ
ajst-6290	138	7	that	that	SCONJ
ajst-6290	138	8	synthetic	synthetic	ADJ
ajst-6290	138	9	biology	biology	NOUN
ajst-6290	138	10	technologies	technology	NOUN
ajst-6290	138	11	may	may	AUX
ajst-6290	138	12	be	be	AUX
ajst-6290	138	13	used	use	VERB
ajst-6290	138	14	for	for	ADP
ajst-6290	138	15	military	military	ADJ
ajst-6290	138	16	purposes	purpose	NOUN
ajst-6290	138	17	,	,	PUNCT
ajst-6290	138	18	leading	lead	VERB
ajst-6290	138	19	to	to	ADP
ajst-6290	138	20	a	a	DET
ajst-6290	138	21	new	new	ADJ
ajst-6290	138	22	arms	arm	NOUN
ajst-6290	138	23	race	race	NOUN
ajst-6290	138	24	and	and	CCONJ
ajst-6290	138	25	the	the	DET
ajst-6290	138	26	threat	threat	NOUN
ajst-6290	138	27	of	of	ADP
ajst-6290	138	28	weaponization	weaponization	NOUN
ajst-6290	138	29	.	.	PUNCT
ajst-6290	139	1	4.3	4.3	NUM
ajst-6290	139	2	.	.	PUNCT
ajst-6290	139	3	policy	policy	NOUN
ajst-6290	139	4	and	and	CCONJ
ajst-6290	139	5	regulatory	regulatory	ADJ
ajst-6290	139	6	developments	development	NOUN
ajst-6290	139	7	policy	policy	NOUN
ajst-6290	139	8	and	and	CCONJ
ajst-6290	139	9	regulation	regulation	NOUN
ajst-6290	139	10	play	play	VERB
ajst-6290	139	11	a	a	DET
ajst-6290	139	12	crucial	crucial	ADJ
ajst-6290	139	13	role	role	NOUN
ajst-6290	139	14	in	in	ADP
ajst-6290	139	15	the	the	DET
ajst-6290	139	16	development	development	NOUN
ajst-6290	139	17	and	and	CCONJ
ajst-6290	139	18	application	application	NOUN
ajst-6290	139	19	of	of	ADP
ajst-6290	139	20	synthetic	synthetic	ADJ
ajst-6290	139	21	biology	biology	NOUN
ajst-6290	139	22	.	.	PUNCT
ajst-6290	140	1	the	the	DET
ajst-6290	140	2	international	international	ADJ
ajst-6290	140	3	community	community	NOUN
ajst-6290	140	4	needs	need	VERB
ajst-6290	140	5	to	to	PART
ajst-6290	140	6	develop	develop	VERB
ajst-6290	140	7	appropriate	appropriate	ADJ
ajst-6290	140	8	policies	policy	NOUN
ajst-6290	140	9	and	and	CCONJ
ajst-6290	140	10	regulations	regulation	NOUN
ajst-6290	140	11	to	to	PART
ajst-6290	140	12	ensure	ensure	VERB
ajst-6290	140	13	the	the	DET
ajst-6290	140	14	safety	safety	NOUN
ajst-6290	140	15	and	and	CCONJ
ajst-6290	140	16	sustainability	sustainability	NOUN
ajst-6290	140	17	of	of	ADP
ajst-6290	140	18	synthetic	synthetic	ADJ
ajst-6290	140	19	biology	biology	NOUN
ajst-6290	140	20	and	and	CCONJ
ajst-6290	140	21	to	to	PART
ajst-6290	140	22	facilitate	facilitate	VERB
ajst-6290	140	23	its	its	PRON
ajst-6290	140	24	development	development	NOUN
ajst-6290	140	25	and	and	CCONJ
ajst-6290	140	26	application	application	NOUN
ajst-6290	140	27	.	.	PUNCT
ajst-6290	141	1	some	some	PRON
ajst-6290	141	2	of	of	ADP
ajst-6290	141	3	the	the	DET
ajst-6290	141	4	key	key	ADJ
ajst-6290	141	5	issues	issue	NOUN
ajst-6290	141	6	include	include	VERB
ajst-6290	141	7	.	.	PUNCT
ajst-6290	142	1	4.3.1	4.3.1	X
ajst-6290	142	2	.	.	PUNCT
ajst-6290	142	3	policy	policy	NOUN
ajst-6290	142	4	and	and	CCONJ
ajst-6290	142	5	regulation	regulation	NOUN
ajst-6290	142	6	of	of	ADP
ajst-6290	142	7	synthetic	synthetic	ADJ
ajst-6290	142	8	biology	biology	NOUN
ajst-6290	142	9	by	by	ADP
ajst-6290	142	10	the	the	DET
ajst-6290	142	11	international	international	ADJ
ajst-6290	142	12	community	community	NOUN
ajst-6290	142	13	currently	currently	ADV
ajst-6290	142	14	,	,	PUNCT
ajst-6290	142	15	the	the	DET
ajst-6290	142	16	international	international	ADJ
ajst-6290	142	17	community	community	NOUN
ajst-6290	142	18	has	have	AUX
ajst-6290	142	19	begun	begin	VERB
ajst-6290	142	20	to	to	PART
ajst-6290	142	21	explore	explore	VERB
ajst-6290	142	22	the	the	DET
ajst-6290	142	23	policy	policy	NOUN
ajst-6290	142	24	and	and	CCONJ
ajst-6290	142	25	regulation	regulation	NOUN
ajst-6290	142	26	of	of	ADP
ajst-6290	142	27	synthetic	synthetic	ADJ
ajst-6290	142	28	biology	biology	NOUN
ajst-6290	142	29	.	.	PUNCT
ajst-6290	143	1	for	for	ADP
ajst-6290	143	2	example	example	NOUN
ajst-6290	143	3	,	,	PUNCT
ajst-6290	143	4	countries	country	NOUN
ajst-6290	143	5	such	such	ADJ
ajst-6290	143	6	as	as	ADP
ajst-6290	143	7	the	the	DET
ajst-6290	143	8	european	european	PROPN
ajst-6290	143	9	union	union	PROPN
ajst-6290	143	10	,	,	PUNCT
ajst-6290	143	11	the	the	DET
ajst-6290	143	12	united	united	PROPN
ajst-6290	143	13	states	states	PROPN
ajst-6290	143	14	,	,	PUNCT
ajst-6290	143	15	and	and	CCONJ
ajst-6290	143	16	japan	japan	PROPN
ajst-6290	143	17	have	have	AUX
ajst-6290	143	18	established	establish	VERB
ajst-6290	143	19	relevant	relevant	ADJ
ajst-6290	143	20	regulations	regulation	NOUN
ajst-6290	143	21	and	and	CCONJ
ajst-6290	143	22	regulatory	regulatory	ADJ
ajst-6290	143	23	mechanisms	mechanism	NOUN
ajst-6290	143	24	to	to	PART
ajst-6290	143	25	ensure	ensure	VERB
ajst-6290	143	26	the	the	DET
ajst-6290	143	27	safety	safety	NOUN
ajst-6290	143	28	and	and	CCONJ
ajst-6290	143	29	sustainability	sustainability	NOUN
ajst-6290	143	30	of	of	ADP
ajst-6290	143	31	synthetic	synthetic	ADJ
ajst-6290	143	32	biology	biology	NOUN
ajst-6290	143	33	.	.	PUNCT
ajst-6290	144	1	in	in	ADP
ajst-6290	144	2	addition	addition	NOUN
ajst-6290	144	3	,	,	PUNCT
ajst-6290	144	4	some	some	DET
ajst-6290	144	5	international	international	ADJ
ajst-6290	144	6	organizations	organization	NOUN
ajst-6290	144	7	,	,	PUNCT
ajst-6290	144	8	such	such	ADJ
ajst-6290	144	9	as	as	ADP
ajst-6290	144	10	the	the	DET
ajst-6290	144	11	united	united	PROPN
ajst-6290	144	12	nations	nations	PROPN
ajst-6290	144	13	environment	environment	NOUN
ajst-6290	144	14	programme	programme	NOUN
ajst-6290	144	15	and	and	CCONJ
ajst-6290	144	16	the	the	DET
ajst-6290	144	17	convention	convention	NOUN
ajst-6290	144	18	on	on	ADP
ajst-6290	144	19	biological	biological	ADJ
ajst-6290	144	20	diversity	diversity	NOUN
ajst-6290	144	21	,	,	PUNCT
ajst-6290	144	22	have	have	AUX
ajst-6290	144	23	also	also	ADV
ajst-6290	144	24	begun	begin	VERB
ajst-6290	144	25	to	to	PART
ajst-6290	144	26	pay	pay	VERB
ajst-6290	144	27	attention	attention	NOUN
ajst-6290	144	28	to	to	ADP
ajst-6290	144	29	the	the	DET
ajst-6290	144	30	impacts	impact	NOUN
ajst-6290	144	31	and	and	CCONJ
ajst-6290	144	32	potential	potential	ADJ
ajst-6290	144	33	threats	threat	NOUN
ajst-6290	144	34	of	of	ADP
ajst-6290	144	35	synthetic	synthetic	ADJ
ajst-6290	144	36	biology	biology	NOUN
ajst-6290	144	37	and	and	CCONJ
ajst-6290	144	38	actively	actively	ADV
ajst-6290	144	39	carry	carry	VERB
ajst-6290	144	40	out	out	ADP
ajst-6290	144	41	related	related	ADJ
ajst-6290	144	42	work	work	NOUN
ajst-6290	144	43	.	.	PUNCT
ajst-6290	145	1	4.3.2	4.3.2	X
ajst-6290	145	2	.	.	PUNCT
ajst-6290	146	1	self	self	NOUN
ajst-6290	146	2	-	-	PUNCT
ajst-6290	146	3	regulation	regulation	NOUN
ajst-6290	146	4	and	and	CCONJ
ajst-6290	146	5	ethical	ethical	ADJ
ajst-6290	146	6	standards	standard	NOUN
ajst-6290	146	7	for	for	ADP
ajst-6290	146	8	synthetic	synthetic	ADJ
ajst-6290	146	9	biology	biology	NOUN
ajst-6290	146	10	researchers	researcher	NOUN
ajst-6290	146	11	in	in	ADP
ajst-6290	146	12	addition	addition	NOUN
ajst-6290	146	13	to	to	ADP
ajst-6290	146	14	policy	policy	NOUN
ajst-6290	146	15	and	and	CCONJ
ajst-6290	146	16	regulation	regulation	NOUN
ajst-6290	146	17	,	,	PUNCT
ajst-6290	146	18	self	self	NOUN
ajst-6290	146	19	-	-	PUNCT
ajst-6290	146	20	regulation	regulation	NOUN
ajst-6290	146	21	and	and	CCONJ
ajst-6290	146	22	ethical	ethical	ADJ
ajst-6290	146	23	standards	standard	NOUN
ajst-6290	146	24	for	for	ADP
ajst-6290	146	25	synthetic	synthetic	ADJ
ajst-6290	146	26	biology	biology	NOUN
ajst-6290	146	27	researchers	researcher	NOUN
ajst-6290	146	28	are	be	AUX
ajst-6290	146	29	also	also	ADV
ajst-6290	146	30	important	important	ADJ
ajst-6290	146	31	.	.	PUNCT
ajst-6290	147	1	synthetic	synthetic	ADJ
ajst-6290	147	2	biology	biology	NOUN
ajst-6290	147	3	researchers	researcher	NOUN
ajst-6290	147	4	and	and	CCONJ
ajst-6290	147	5	institutions	institution	NOUN
ajst-6290	147	6	need	need	VERB
ajst-6290	147	7	to	to	PART
ajst-6290	147	8	establish	establish	VERB
ajst-6290	147	9	their	their	PRON
ajst-6290	147	10	own	own	ADJ
ajst-6290	147	11	ethical	ethical	ADJ
ajst-6290	147	12	and	and	CCONJ
ajst-6290	147	13	moral	moral	ADJ
ajst-6290	147	14	standards	standard	NOUN
ajst-6290	147	15	to	to	PART
ajst-6290	147	16	ensure	ensure	VERB
ajst-6290	147	17	that	that	SCONJ
ajst-6290	147	18	their	their	PRON
ajst-6290	147	19	research	research	NOUN
ajst-6290	147	20	and	and	CCONJ
ajst-6290	147	21	applications	application	NOUN
ajst-6290	147	22	do	do	AUX
ajst-6290	147	23	not	not	PART
ajst-6290	147	24	pose	pose	VERB
ajst-6290	147	25	potential	potential	ADJ
ajst-6290	147	26	harm	harm	NOUN
ajst-6290	147	27	to	to	ADP
ajst-6290	147	28	humans	human	NOUN
ajst-6290	147	29	and	and	CCONJ
ajst-6290	147	30	the	the	DET
ajst-6290	147	31	environment	environment	NOUN
ajst-6290	147	32	.	.	PUNCT
ajst-6290	148	1	in	in	ADP
ajst-6290	148	2	addition	addition	NOUN
ajst-6290	148	3	,	,	PUNCT
ajst-6290	148	4	researchers	researcher	NOUN
ajst-6290	148	5	and	and	CCONJ
ajst-6290	148	6	institutions	institution	NOUN
ajst-6290	148	7	need	need	VERB
ajst-6290	148	8	to	to	PART
ajst-6290	148	9	actively	actively	ADV
ajst-6290	148	10	communicate	communicate	VERB
ajst-6290	148	11	with	with	ADP
ajst-6290	148	12	the	the	DET
ajst-6290	148	13	public	public	ADJ
ajst-6290	148	14	and	and	CCONJ
ajst-6290	148	15	policy	policy	NOUN
ajst-6290	148	16	makers	maker	NOUN
ajst-6290	148	17	about	about	ADP
ajst-6290	148	18	the	the	DET
ajst-6290	148	19	direction	direction	NOUN
ajst-6290	148	20	and	and	CCONJ
ajst-6290	148	21	scope	scope	NOUN
ajst-6290	148	22	of	of	ADP
ajst-6290	148	23	applications	application	NOUN
ajst-6290	148	24	of	of	ADP
ajst-6290	148	25	synthetic	synthetic	ADJ
ajst-6290	148	26	biology	biology	NOUN
ajst-6290	148	27	in	in	ADP
ajst-6290	148	28	order	order	NOUN
ajst-6290	148	29	to	to	PART
ajst-6290	148	30	promote	promote	VERB
ajst-6290	148	31	its	its	PRON
ajst-6290	148	32	sustainable	sustainable	ADJ
ajst-6290	148	33	development	development	NOUN
ajst-6290	148	34	.	.	PUNCT
ajst-6290	149	1	overall	overall	ADJ
ajst-6290	149	2	,	,	PUNCT
ajst-6290	149	3	synthetic	synthetic	ADJ
ajst-6290	149	4	biology	biology	NOUN
ajst-6290	149	5	is	be	AUX
ajst-6290	149	6	a	a	DET
ajst-6290	149	7	rapidly	rapidly	ADV
ajst-6290	149	8	developing	develop	VERB
ajst-6290	149	9	and	and	CCONJ
ajst-6290	149	10	emerging	emerge	VERB
ajst-6290	149	11	field	field	NOUN
ajst-6290	149	12	with	with	ADP
ajst-6290	149	13	promising	promising	ADJ
ajst-6290	149	14	technologies	technology	NOUN
ajst-6290	149	15	and	and	CCONJ
ajst-6290	149	16	potential	potential	ADJ
ajst-6290	149	17	applications	application	NOUN
ajst-6290	149	18	.	.	PUNCT
ajst-6290	150	1	however	however	ADV
ajst-6290	150	2	,	,	PUNCT
ajst-6290	150	3	at	at	ADP
ajst-6290	150	4	the	the	DET
ajst-6290	150	5	same	same	ADJ
ajst-6290	150	6	time	time	NOUN
ajst-6290	150	7	,	,	PUNCT
ajst-6290	150	8	its	its	PRON
ajst-6290	150	9	potential	potential	ADJ
ajst-6290	150	10	dangers	danger	NOUN
ajst-6290	150	11	and	and	CCONJ
ajst-6290	150	12	safety	safety	NOUN
ajst-6290	150	13	issues	issue	NOUN
ajst-6290	150	14	,	,	PUNCT
ajst-6290	150	15	as	as	ADV
ajst-6290	150	16	well	well	ADV
ajst-6290	150	17	as	as	ADP
ajst-6290	150	18	its	its	PRON
ajst-6290	150	19	ethical	ethical	ADJ
ajst-6290	150	20	,	,	PUNCT
ajst-6290	150	21	social	social	ADJ
ajst-6290	150	22	,	,	PUNCT
ajst-6290	150	23	and	and	CCONJ
ajst-6290	150	24	cultural	cultural	ADJ
ajst-6290	150	25	implications	implication	NOUN
ajst-6290	150	26	,	,	PUNCT
ajst-6290	150	27	need	need	VERB
ajst-6290	150	28	to	to	PART
ajst-6290	150	29	be	be	AUX
ajst-6290	150	30	carefully	carefully	ADV
ajst-6290	150	31	explored	explore	VERB
ajst-6290	150	32	.	.	PUNCT
ajst-6290	151	1	to	to	PART
ajst-6290	151	2	ensure	ensure	VERB
ajst-6290	151	3	the	the	DET
ajst-6290	151	4	safety	safety	NOUN
ajst-6290	151	5	and	and	CCONJ
ajst-6290	151	6	sustainability	sustainability	NOUN
ajst-6290	151	7	of	of	ADP
ajst-6290	151	8	synthetic	synthetic	ADJ
ajst-6290	151	9	biology	biology	NOUN
ajst-6290	151	10	,	,	PUNCT
ajst-6290	151	11	relevant	relevant	ADJ
ajst-6290	151	12	policies	policy	NOUN
ajst-6290	151	13	and	and	CCONJ
ajst-6290	151	14	regulations	regulation	NOUN
ajst-6290	151	15	need	need	VERB
ajst-6290	151	16	to	to	PART
ajst-6290	151	17	be	be	AUX
ajst-6290	151	18	strengthened	strengthen	VERB
ajst-6290	151	19	,	,	PUNCT
ajst-6290	151	20	and	and	CCONJ
ajst-6290	151	21	selfregulation	selfregulation	NOUN
ajst-6290	151	22	and	and	CCONJ
ajst-6290	151	23	ethical	ethical	ADJ
ajst-6290	151	24	standards	standard	NOUN
ajst-6290	151	25	need	need	VERB
ajst-6290	151	26	to	to	PART
ajst-6290	151	27	be	be	AUX
ajst-6290	151	28	established	establish	VERB
ajst-6290	151	29	for	for	ADP
ajst-6290	151	30	its	its	PRON
ajst-6290	151	31	sustainable	sustainable	ADJ
ajst-6290	151	32	development	development	NOUN
ajst-6290	151	33	and	and	CCONJ
ajst-6290	151	34	application	application	NOUN
ajst-6290	151	35	.	.	PUNCT
ajst-6290	152	1	5	5	X
ajst-6290	152	2	.	.	X
ajst-6290	152	3	future	future	ADJ
ajst-6290	152	4	development	development	NOUN
ajst-6290	152	5	of	of	ADP
ajst-6290	152	6	synthetic	synthetic	ADJ
ajst-6290	152	7	biology	biology	NOUN
ajst-6290	152	8	5.1	5.1	NUM
ajst-6290	152	9	.	.	PUNCT
ajst-6290	153	1	future	future	ADJ
ajst-6290	153	2	application	application	NOUN
ajst-6290	153	3	areas	area	NOUN
ajst-6290	153	4	of	of	ADP
ajst-6290	153	5	synthetic	synthetic	ADJ
ajst-6290	153	6	biology	biology	NOUN
ajst-6290	153	7	synthetic	synthetic	ADJ
ajst-6290	153	8	biology	biology	NOUN
ajst-6290	153	9	is	be	AUX
ajst-6290	153	10	a	a	DET
ajst-6290	153	11	rapidly	rapidly	ADV
ajst-6290	153	12	developing	develop	VERB
ajst-6290	153	13	emerging	emerge	VERB
ajst-6290	153	14	discipline	discipline	NOUN
ajst-6290	153	15	,	,	PUNCT
ajst-6290	153	16	and	and	CCONJ
ajst-6290	153	17	its	its	PRON
ajst-6290	153	18	future	future	ADJ
ajst-6290	153	19	development	development	NOUN
ajst-6290	153	20	has	have	VERB
ajst-6290	153	21	a	a	DET
ajst-6290	153	22	broad	broad	ADJ
ajst-6290	153	23	prospect	prospect	NOUN
ajst-6290	153	24	and	and	CCONJ
ajst-6290	153	25	great	great	ADJ
ajst-6290	153	26	potential	potential	NOUN
ajst-6290	153	27	.	.	PUNCT
ajst-6290	154	1	in	in	ADP
ajst-6290	154	2	the	the	DET
ajst-6290	154	3	future	future	NOUN
ajst-6290	154	4	,	,	PUNCT
ajst-6290	154	5	the	the	DET
ajst-6290	154	6	technological	technological	ADJ
ajst-6290	154	7	99	99	NUM
ajst-6290	154	8	development	development	NOUN
ajst-6290	154	9	trends	trend	NOUN
ajst-6290	154	10	of	of	ADP
ajst-6290	154	11	synthetic	synthetic	ADJ
ajst-6290	154	12	biology	biology	NOUN
ajst-6290	154	13	mainly	mainly	ADV
ajst-6290	154	14	include	include	VERB
ajst-6290	154	15	synthetic	synthetic	ADJ
ajst-6290	154	16	genome	genome	NOUN
ajst-6290	154	17	and	and	CCONJ
ajst-6290	154	18	whole	whole	ADJ
ajst-6290	154	19	cell	cell	NOUN
ajst-6290	154	20	simulation	simulation	NOUN
ajst-6290	154	21	with	with	ADP
ajst-6290	154	22	the	the	DET
ajst-6290	154	23	continuous	continuous	ADJ
ajst-6290	154	24	development	development	NOUN
ajst-6290	154	25	of	of	ADP
ajst-6290	154	26	gene	gene	NOUN
ajst-6290	154	27	synthesis	synthesis	NOUN
ajst-6290	154	28	and	and	CCONJ
ajst-6290	154	29	assembly	assembly	NOUN
ajst-6290	154	30	technologies	technology	NOUN
ajst-6290	154	31	,	,	PUNCT
ajst-6290	154	32	people	people	NOUN
ajst-6290	154	33	can	can	AUX
ajst-6290	154	34	construct	construct	VERB
ajst-6290	154	35	and	and	CCONJ
ajst-6290	154	36	modify	modify	VERB
ajst-6290	154	37	cellular	cellular	ADJ
ajst-6290	154	38	genomes	genome	NOUN
ajst-6290	154	39	more	more	ADV
ajst-6290	154	40	freely	freely	ADV
ajst-6290	154	41	.	.	PUNCT
ajst-6290	155	1	whole	whole	ADJ
ajst-6290	155	2	-	-	PUNCT
ajst-6290	155	3	cell	cell	NOUN
ajst-6290	155	4	simulation	simulation	NOUN
ajst-6290	155	5	,	,	PUNCT
ajst-6290	155	6	on	on	ADP
ajst-6290	155	7	the	the	DET
ajst-6290	155	8	other	other	ADJ
ajst-6290	155	9	hand	hand	NOUN
ajst-6290	155	10	,	,	PUNCT
ajst-6290	155	11	can	can	AUX
ajst-6290	155	12	help	help	VERB
ajst-6290	155	13	people	people	NOUN
ajst-6290	155	14	better	well	ADV
ajst-6290	155	15	understand	understand	VERB
ajst-6290	155	16	and	and	CCONJ
ajst-6290	155	17	predict	predict	VERB
ajst-6290	155	18	cellular	cellular	ADJ
ajst-6290	155	19	behavior	behavior	NOUN
ajst-6290	155	20	and	and	CCONJ
ajst-6290	155	21	responses	response	NOUN
ajst-6290	155	22	.	.	PUNCT
ajst-6290	156	1	the	the	DET
ajst-6290	156	2	combination	combination	NOUN
ajst-6290	156	3	of	of	ADP
ajst-6290	156	4	these	these	DET
ajst-6290	156	5	technologies	technology	NOUN
ajst-6290	156	6	will	will	AUX
ajst-6290	156	7	make	make	VERB
ajst-6290	156	8	the	the	DET
ajst-6290	156	9	study	study	NOUN
ajst-6290	156	10	of	of	ADP
ajst-6290	156	11	synthetic	synthetic	ADJ
ajst-6290	156	12	biology	biology	NOUN
ajst-6290	156	13	more	more	ADV
ajst-6290	156	14	efficient	efficient	ADJ
ajst-6290	156	15	and	and	CCONJ
ajst-6290	156	16	accurate	accurate	ADJ
ajst-6290	156	17	.	.	PUNCT
ajst-6290	157	1	biointelligent	biointelligent	ADJ
ajst-6290	157	2	systems	system	NOUN
ajst-6290	157	3	and	and	CCONJ
ajst-6290	157	4	biocomputing	biocomputing	NOUN
ajst-6290	157	5	bio	bio	ADJ
ajst-6290	157	6	-	-	ADJ
ajst-6290	157	7	intelligent	intelligent	ADJ
ajst-6290	157	8	systems	system	NOUN
ajst-6290	157	9	and	and	CCONJ
ajst-6290	157	10	biocomputing	biocomputing	NOUN
ajst-6290	157	11	are	be	AUX
ajst-6290	157	12	another	another	DET
ajst-6290	157	13	important	important	ADJ
ajst-6290	157	14	development	development	NOUN
ajst-6290	157	15	in	in	ADP
ajst-6290	157	16	synthetic	synthetic	ADJ
ajst-6290	157	17	biology	biology	NOUN
ajst-6290	157	18	.	.	PUNCT
ajst-6290	158	1	by	by	ADP
ajst-6290	158	2	building	build	VERB
ajst-6290	158	3	biological	biological	ADJ
ajst-6290	158	4	systems	system	NOUN
ajst-6290	158	5	with	with	ADP
ajst-6290	158	6	intelligent	intelligent	ADJ
ajst-6290	158	7	properties	property	NOUN
ajst-6290	158	8	,	,	PUNCT
ajst-6290	158	9	one	one	PRON
ajst-6290	158	10	can	can	AUX
ajst-6290	158	11	achieve	achieve	VERB
ajst-6290	158	12	more	more	ADV
ajst-6290	158	13	efficient	efficient	ADJ
ajst-6290	158	14	and	and	CCONJ
ajst-6290	158	15	accurate	accurate	ADJ
ajst-6290	158	16	biological	biological	ADJ
ajst-6290	158	17	reactions	reaction	NOUN
ajst-6290	158	18	and	and	CCONJ
ajst-6290	158	19	production	production	NOUN
ajst-6290	158	20	processes	process	NOUN
ajst-6290	158	21	.	.	PUNCT
ajst-6290	159	1	in	in	ADP
ajst-6290	159	2	addition	addition	NOUN
ajst-6290	159	3	,	,	PUNCT
ajst-6290	159	4	biocomputing	biocomputing	NOUN
ajst-6290	159	5	can	can	AUX
ajst-6290	159	6	also	also	ADV
ajst-6290	159	7	help	help	VERB
ajst-6290	159	8	people	people	NOUN
ajst-6290	159	9	better	well	ADV
ajst-6290	159	10	understand	understand	VERB
ajst-6290	159	11	and	and	CCONJ
ajst-6290	159	12	model	model	VERB
ajst-6290	159	13	the	the	DET
ajst-6290	159	14	behavior	behavior	NOUN
ajst-6290	159	15	and	and	CCONJ
ajst-6290	159	16	properties	property	NOUN
ajst-6290	159	17	of	of	ADP
ajst-6290	159	18	living	living	NOUN
ajst-6290	159	19	systems	system	NOUN
ajst-6290	159	20	.	.	PUNCT
ajst-6290	160	1	bioengineering	bioengineering	NOUN
ajst-6290	160	2	and	and	CCONJ
ajst-6290	160	3	manufacturing	manufacturing	NOUN
ajst-6290	160	4	bioengineering	bioengineering	NOUN
ajst-6290	160	5	and	and	CCONJ
ajst-6290	160	6	manufacturing	manufacturing	NOUN
ajst-6290	160	7	is	be	AUX
ajst-6290	160	8	one	one	NUM
ajst-6290	160	9	of	of	ADP
ajst-6290	160	10	the	the	DET
ajst-6290	160	11	most	most	ADV
ajst-6290	160	12	widely	widely	ADV
ajst-6290	160	13	used	use	VERB
ajst-6290	160	14	areas	area	NOUN
ajst-6290	160	15	of	of	ADP
ajst-6290	160	16	synthetic	synthetic	ADJ
ajst-6290	160	17	biology	biology	NOUN
ajst-6290	160	18	.	.	PUNCT
ajst-6290	161	1	in	in	ADP
ajst-6290	161	2	the	the	DET
ajst-6290	161	3	future	future	NOUN
ajst-6290	161	4	,	,	PUNCT
ajst-6290	161	5	as	as	SCONJ
ajst-6290	161	6	biosynthesis	biosynthesis	NOUN
ajst-6290	161	7	and	and	CCONJ
ajst-6290	161	8	manufacturing	manufacturing	NOUN
ajst-6290	161	9	technologies	technology	NOUN
ajst-6290	161	10	continue	continue	VERB
ajst-6290	161	11	to	to	PART
ajst-6290	161	12	develop	develop	VERB
ajst-6290	161	13	,	,	PUNCT
ajst-6290	161	14	humans	human	NOUN
ajst-6290	161	15	will	will	AUX
ajst-6290	161	16	be	be	AUX
ajst-6290	161	17	able	able	ADJ
ajst-6290	161	18	to	to	PART
ajst-6290	161	19	produce	produce	VERB
ajst-6290	161	20	a	a	DET
ajst-6290	161	21	variety	variety	NOUN
ajst-6290	161	22	of	of	ADP
ajst-6290	161	23	biological	biological	ADJ
ajst-6290	161	24	products	product	NOUN
ajst-6290	161	25	,	,	PUNCT
ajst-6290	161	26	including	include	VERB
ajst-6290	161	27	pharmaceuticals	pharmaceutical	NOUN
ajst-6290	161	28	,	,	PUNCT
ajst-6290	161	29	chemicals	chemical	NOUN
ajst-6290	161	30	,	,	PUNCT
ajst-6290	161	31	and	and	CCONJ
ajst-6290	161	32	fuels	fuel	NOUN
ajst-6290	161	33	,	,	PUNCT
ajst-6290	161	34	more	more	ADV
ajst-6290	161	35	efficiently	efficiently	ADV
ajst-6290	161	36	.	.	PUNCT
ajst-6290	162	1	future	future	ADJ
ajst-6290	162	2	applications	application	NOUN
ajst-6290	162	3	of	of	ADP
ajst-6290	162	4	synthetic	synthetic	ADJ
ajst-6290	162	5	biology	biology	NOUN
ajst-6290	162	6	include	include	VERB
ajst-6290	162	7	medical	medical	ADJ
ajst-6290	162	8	and	and	CCONJ
ajst-6290	162	9	biomedical	biomedical	ADJ
ajst-6290	162	10	research	research	NOUN
ajst-6290	162	11	the	the	DET
ajst-6290	162	12	application	application	NOUN
ajst-6290	162	13	of	of	ADP
ajst-6290	162	14	synthetic	synthetic	ADJ
ajst-6290	162	15	biology	biology	NOUN
ajst-6290	162	16	in	in	ADP
ajst-6290	162	17	medical	medical	ADJ
ajst-6290	162	18	and	and	CCONJ
ajst-6290	162	19	biomedical	biomedical	ADJ
ajst-6290	162	20	research	research	NOUN
ajst-6290	162	21	is	be	AUX
ajst-6290	162	22	very	very	ADV
ajst-6290	162	23	promising	promising	ADJ
ajst-6290	162	24	.	.	PUNCT
ajst-6290	163	1	through	through	ADP
ajst-6290	163	2	synthetic	synthetic	ADJ
ajst-6290	163	3	genomic	genomic	NOUN
ajst-6290	163	4	and	and	CCONJ
ajst-6290	163	5	cellular	cellular	ADJ
ajst-6290	163	6	engineering	engineering	NOUN
ajst-6290	163	7	techniques	technique	NOUN
ajst-6290	163	8	,	,	PUNCT
ajst-6290	163	9	people	people	NOUN
ajst-6290	163	10	can	can	AUX
ajst-6290	163	11	achieve	achieve	VERB
ajst-6290	163	12	more	more	ADV
ajst-6290	163	13	efficient	efficient	ADJ
ajst-6290	163	14	and	and	CCONJ
ajst-6290	163	15	precise	precise	ADJ
ajst-6290	163	16	diagnosis	diagnosis	NOUN
ajst-6290	163	17	and	and	CCONJ
ajst-6290	163	18	treatment	treatment	NOUN
ajst-6290	163	19	of	of	ADP
ajst-6290	163	20	diseases	disease	NOUN
ajst-6290	163	21	.	.	PUNCT
ajst-6290	164	1	industrial	industrial	ADJ
ajst-6290	164	2	and	and	CCONJ
ajst-6290	164	3	environmental	environmental	ADJ
ajst-6290	164	4	protection	protection	NOUN
ajst-6290	164	5	synthetic	synthetic	ADJ
ajst-6290	164	6	biology	biology	NOUN
ajst-6290	164	7	also	also	ADV
ajst-6290	164	8	has	have	VERB
ajst-6290	164	9	a	a	DET
ajst-6290	164	10	wide	wide	ADJ
ajst-6290	164	11	range	range	NOUN
ajst-6290	164	12	of	of	ADP
ajst-6290	164	13	promising	promising	ADJ
ajst-6290	164	14	applications	application	NOUN
ajst-6290	164	15	in	in	ADP
ajst-6290	164	16	the	the	DET
ajst-6290	164	17	fields	field	NOUN
ajst-6290	164	18	of	of	ADP
ajst-6290	164	19	industry	industry	NOUN
ajst-6290	164	20	and	and	CCONJ
ajst-6290	164	21	environmental	environmental	ADJ
ajst-6290	164	22	protection	protection	NOUN
ajst-6290	164	23	.	.	PUNCT
ajst-6290	165	1	for	for	ADP
ajst-6290	165	2	example	example	NOUN
ajst-6290	165	3	,	,	PUNCT
ajst-6290	165	4	biosynthesis	biosynthesis	NOUN
ajst-6290	165	5	technologies	technology	NOUN
ajst-6290	165	6	can	can	AUX
ajst-6290	165	7	lead	lead	VERB
ajst-6290	165	8	to	to	ADP
ajst-6290	165	9	more	more	ADV
ajst-6290	165	10	environmentally	environmentally	ADV
ajst-6290	165	11	friendly	friendly	ADJ
ajst-6290	165	12	and	and	CCONJ
ajst-6290	165	13	sustainable	sustainable	ADJ
ajst-6290	165	14	processes	process	NOUN
ajst-6290	165	15	for	for	ADP
ajst-6290	165	16	the	the	DET
ajst-6290	165	17	production	production	NOUN
ajst-6290	165	18	of	of	ADP
ajst-6290	165	19	chemicals	chemical	NOUN
ajst-6290	165	20	and	and	CCONJ
ajst-6290	165	21	materials	material	NOUN
ajst-6290	165	22	.	.	PUNCT
ajst-6290	166	1	agriculture	agriculture	NOUN
ajst-6290	166	2	and	and	CCONJ
ajst-6290	166	3	food	food	NOUN
ajst-6290	166	4	production	production	NOUN
ajst-6290	166	5	in	in	ADP
ajst-6290	166	6	agriculture	agriculture	NOUN
ajst-6290	166	7	and	and	CCONJ
ajst-6290	166	8	food	food	NOUN
ajst-6290	166	9	production	production	NOUN
ajst-6290	166	10	,	,	PUNCT
ajst-6290	166	11	synthetic	synthetic	ADJ
ajst-6290	166	12	biology	biology	NOUN
ajst-6290	166	13	can	can	AUX
ajst-6290	166	14	help	help	VERB
ajst-6290	166	15	people	people	NOUN
ajst-6290	166	16	achieve	achieve	VERB
ajst-6290	166	17	more	more	ADV
ajst-6290	166	18	efficient	efficient	ADJ
ajst-6290	166	19	and	and	CCONJ
ajst-6290	166	20	sustainable	sustainable	ADJ
ajst-6290	166	21	crop	crop	NOUN
ajst-6290	166	22	and	and	CCONJ
ajst-6290	166	23	food	food	NOUN
ajst-6290	166	24	production	production	NOUN
ajst-6290	166	25	to	to	PART
ajst-6290	166	26	meet	meet	VERB
ajst-6290	166	27	the	the	DET
ajst-6290	166	28	needs	need	NOUN
ajst-6290	166	29	of	of	ADP
ajst-6290	166	30	the	the	DET
ajst-6290	166	31	growing	grow	VERB
ajst-6290	166	32	global	global	ADJ
ajst-6290	166	33	population	population	NOUN
ajst-6290	166	34	.	.	PUNCT
ajst-6290	167	1	5.2	5.2	NUM
ajst-6290	167	2	.	.	PUNCT
ajst-6290	167	3	challenges	challenge	NOUN
ajst-6290	167	4	and	and	CCONJ
ajst-6290	167	5	opportunities	opportunity	NOUN
ajst-6290	167	6	for	for	ADP
ajst-6290	167	7	the	the	DET
ajst-6290	167	8	development	development	NOUN
ajst-6290	167	9	of	of	ADP
ajst-6290	167	10	synthetic	synthetic	ADJ
ajst-6290	167	11	biology	biology	NOUN
ajst-6290	167	12	there	there	PRON
ajst-6290	167	13	are	be	VERB
ajst-6290	167	14	both	both	DET
ajst-6290	167	15	opportunities	opportunity	NOUN
ajst-6290	167	16	and	and	CCONJ
ajst-6290	167	17	challenges	challenge	NOUN
ajst-6290	167	18	for	for	ADP
ajst-6290	167	19	the	the	DET
ajst-6290	167	20	future	future	ADJ
ajst-6290	167	21	development	development	NOUN
ajst-6290	167	22	of	of	ADP
ajst-6290	167	23	synthetic	synthetic	ADJ
ajst-6290	167	24	biology	biology	NOUN
ajst-6290	167	25	.	.	PUNCT
ajst-6290	168	1	some	some	PRON
ajst-6290	168	2	of	of	ADP
ajst-6290	168	3	the	the	DET
ajst-6290	168	4	key	key	ADJ
ajst-6290	168	5	issues	issue	NOUN
ajst-6290	168	6	include	include	VERB
ajst-6290	168	7	.	.	PUNCT
ajst-6290	169	1	5.2.1	5.2.1	X
ajst-6290	169	2	.	.	PUNCT
ajst-6290	169	3	scientific	scientific	ADJ
ajst-6290	169	4	and	and	CCONJ
ajst-6290	169	5	technical	technical	ADJ
ajst-6290	169	6	challenges	challenge	NOUN
ajst-6290	169	7	there	there	PRON
ajst-6290	169	8	are	be	VERB
ajst-6290	169	9	still	still	ADV
ajst-6290	169	10	some	some	DET
ajst-6290	169	11	technical	technical	ADJ
ajst-6290	169	12	limitations	limitation	NOUN
ajst-6290	169	13	in	in	ADP
ajst-6290	169	14	synthetic	synthetic	ADJ
ajst-6290	169	15	biology	biology	NOUN
ajst-6290	169	16	.	.	PUNCT
ajst-6290	170	1	chief	chief	NOUN
ajst-6290	170	2	among	among	ADP
ajst-6290	170	3	these	these	PRON
ajst-6290	170	4	is	be	AUX
ajst-6290	170	5	how	how	SCONJ
ajst-6290	170	6	to	to	PART
ajst-6290	170	7	precisely	precisely	ADV
ajst-6290	170	8	design	design	VERB
ajst-6290	170	9	and	and	CCONJ
ajst-6290	170	10	construct	construct	VERB
ajst-6290	170	11	synthetic	synthetic	ADJ
ajst-6290	170	12	biological	biological	ADJ
ajst-6290	170	13	systems	system	NOUN
ajst-6290	170	14	to	to	PART
ajst-6290	170	15	achieve	achieve	VERB
ajst-6290	170	16	the	the	DET
ajst-6290	170	17	desired	desire	VERB
ajst-6290	170	18	results	result	NOUN
ajst-6290	170	19	.	.	PUNCT
ajst-6290	171	1	at	at	ADP
ajst-6290	171	2	present	present	ADJ
ajst-6290	171	3	,	,	PUNCT
ajst-6290	171	4	the	the	DET
ajst-6290	171	5	technology	technology	NOUN
ajst-6290	171	6	of	of	ADP
ajst-6290	171	7	synthetic	synthetic	ADJ
ajst-6290	171	8	biology	biology	NOUN
ajst-6290	171	9	still	still	ADV
ajst-6290	171	10	suffers	suffer	VERB
ajst-6290	171	11	from	from	ADP
ajst-6290	171	12	certain	certain	ADJ
ajst-6290	171	13	errors	error	NOUN
ajst-6290	171	14	and	and	CCONJ
ajst-6290	171	15	uncertainties	uncertainty	NOUN
ajst-6290	171	16	,	,	PUNCT
ajst-6290	171	17	and	and	CCONJ
ajst-6290	171	18	needs	need	VERB
ajst-6290	171	19	to	to	PART
ajst-6290	171	20	be	be	AUX
ajst-6290	171	21	continuously	continuously	ADV
ajst-6290	171	22	improved	improve	VERB
ajst-6290	171	23	and	and	CCONJ
ajst-6290	171	24	optimized	optimize	VERB
ajst-6290	171	25	.	.	PUNCT
ajst-6290	172	1	in	in	ADP
ajst-6290	172	2	addition	addition	NOUN
ajst-6290	172	3	,	,	PUNCT
ajst-6290	172	4	synthetic	synthetic	ADJ
ajst-6290	172	5	biology	biology	NOUN
ajst-6290	172	6	also	also	ADV
ajst-6290	172	7	faces	face	VERB
ajst-6290	172	8	some	some	DET
ajst-6290	172	9	technical	technical	ADJ
ajst-6290	172	10	challenges	challenge	NOUN
ajst-6290	172	11	,	,	PUNCT
ajst-6290	172	12	such	such	ADJ
ajst-6290	172	13	as	as	ADP
ajst-6290	172	14	how	how	SCONJ
ajst-6290	172	15	to	to	PART
ajst-6290	172	16	achieve	achieve	VERB
ajst-6290	172	17	efficient	efficient	ADJ
ajst-6290	172	18	genome	genome	NOUN
ajst-6290	172	19	editing	editing	NOUN
ajst-6290	172	20	and	and	CCONJ
ajst-6290	172	21	synthesis	synthesis	NOUN
ajst-6290	172	22	,	,	PUNCT
ajst-6290	172	23	how	how	SCONJ
ajst-6290	172	24	to	to	PART
ajst-6290	172	25	achieve	achieve	VERB
ajst-6290	172	26	high	high	ADJ
ajst-6290	172	27	-	-	PUNCT
ajst-6290	172	28	throughput	throughput	NOUN
ajst-6290	172	29	genome	genome	NOUN
ajst-6290	172	30	sequencing	sequencing	NOUN
ajst-6290	172	31	and	and	CCONJ
ajst-6290	172	32	data	datum	NOUN
ajst-6290	172	33	analysis	analysis	NOUN
ajst-6290	172	34	,	,	PUNCT
ajst-6290	172	35	and	and	CCONJ
ajst-6290	172	36	so	so	ADV
ajst-6290	172	37	on	on	ADV
ajst-6290	172	38	.	.	PUNCT
ajst-6290	173	1	solving	solve	VERB
ajst-6290	173	2	these	these	DET
ajst-6290	173	3	technical	technical	ADJ
ajst-6290	173	4	challenges	challenge	NOUN
ajst-6290	173	5	requires	require	VERB
ajst-6290	173	6	not	not	PART
ajst-6290	173	7	only	only	ADV
ajst-6290	173	8	the	the	DET
ajst-6290	173	9	efforts	effort	NOUN
ajst-6290	173	10	of	of	ADP
ajst-6290	173	11	technical	technical	ADJ
ajst-6290	173	12	staff	staff	NOUN
ajst-6290	173	13	,	,	PUNCT
ajst-6290	173	14	but	but	CCONJ
ajst-6290	173	15	also	also	ADV
ajst-6290	173	16	the	the	DET
ajst-6290	173	17	support	support	NOUN
ajst-6290	173	18	and	and	CCONJ
ajst-6290	173	19	input	input	NOUN
ajst-6290	173	20	from	from	ADP
ajst-6290	173	21	various	various	ADJ
ajst-6290	173	22	parties	party	NOUN
ajst-6290	173	23	.	.	PUNCT
ajst-6290	174	1	in	in	ADP
ajst-6290	174	2	addition	addition	NOUN
ajst-6290	174	3	to	to	ADP
ajst-6290	174	4	technical	technical	ADJ
ajst-6290	174	5	challenges	challenge	NOUN
ajst-6290	174	6	,	,	PUNCT
ajst-6290	174	7	synthetic	synthetic	ADJ
ajst-6290	174	8	biology	biology	NOUN
ajst-6290	174	9	also	also	ADV
ajst-6290	174	10	faces	face	VERB
ajst-6290	174	11	a	a	DET
ajst-6290	174	12	number	number	NOUN
ajst-6290	174	13	of	of	ADP
ajst-6290	174	14	scientific	scientific	ADJ
ajst-6290	174	15	challenges	challenge	NOUN
ajst-6290	174	16	.	.	PUNCT
ajst-6290	175	1	for	for	ADP
ajst-6290	175	2	example	example	NOUN
ajst-6290	175	3	,	,	PUNCT
ajst-6290	175	4	how	how	SCONJ
ajst-6290	175	5	to	to	PART
ajst-6290	175	6	deeply	deeply	ADV
ajst-6290	175	7	understand	understand	VERB
ajst-6290	175	8	the	the	DET
ajst-6290	175	9	nature	nature	NOUN
ajst-6290	175	10	and	and	CCONJ
ajst-6290	175	11	laws	law	NOUN
ajst-6290	175	12	of	of	ADP
ajst-6290	175	13	living	living	NOUN
ajst-6290	175	14	systems	system	NOUN
ajst-6290	175	15	,	,	PUNCT
ajst-6290	175	16	and	and	CCONJ
ajst-6290	175	17	how	how	SCONJ
ajst-6290	175	18	to	to	PART
ajst-6290	175	19	accurately	accurately	ADV
ajst-6290	175	20	model	model	VERB
ajst-6290	175	21	and	and	CCONJ
ajst-6290	175	22	predict	predict	VERB
ajst-6290	175	23	the	the	DET
ajst-6290	175	24	behavior	behavior	NOUN
ajst-6290	175	25	of	of	ADP
ajst-6290	175	26	biological	biological	ADJ
ajst-6290	175	27	systems	system	NOUN
ajst-6290	175	28	.	.	PUNCT
ajst-6290	176	1	these	these	DET
ajst-6290	176	2	scientific	scientific	ADJ
ajst-6290	176	3	challenges	challenge	NOUN
ajst-6290	176	4	require	require	VERB
ajst-6290	176	5	interdisciplinary	interdisciplinary	ADJ
ajst-6290	176	6	collaboration	collaboration	NOUN
ajst-6290	176	7	and	and	CCONJ
ajst-6290	176	8	joint	joint	ADJ
ajst-6290	176	9	efforts	effort	NOUN
ajst-6290	176	10	to	to	PART
ajst-6290	176	11	solve	solve	VERB
ajst-6290	176	12	.	.	PUNCT
ajst-6290	177	1	5.2.2	5.2.2	X
ajst-6290	177	2	.	.	NOUN
ajst-6290	177	3	social	social	ADJ
ajst-6290	177	4	and	and	CCONJ
ajst-6290	177	5	policy	policy	NOUN
ajst-6290	177	6	challenges	challenge	NOUN
ajst-6290	177	7	with	with	ADP
ajst-6290	177	8	the	the	DET
ajst-6290	177	9	continuous	continuous	ADJ
ajst-6290	177	10	development	development	NOUN
ajst-6290	177	11	of	of	ADP
ajst-6290	177	12	synthetic	synthetic	ADJ
ajst-6290	177	13	biology	biology	NOUN
ajst-6290	177	14	technology	technology	NOUN
ajst-6290	177	15	,	,	PUNCT
ajst-6290	177	16	related	relate	VERB
ajst-6290	177	17	social	social	ADJ
ajst-6290	177	18	and	and	CCONJ
ajst-6290	177	19	policy	policy	NOUN
ajst-6290	177	20	issues	issue	NOUN
ajst-6290	177	21	have	have	AUX
ajst-6290	177	22	emerged	emerge	VERB
ajst-6290	177	23	.	.	PUNCT
ajst-6290	178	1	on	on	ADP
ajst-6290	178	2	the	the	DET
ajst-6290	178	3	one	one	NUM
ajst-6290	178	4	hand	hand	NOUN
ajst-6290	178	5	,	,	PUNCT
ajst-6290	178	6	the	the	DET
ajst-6290	178	7	public	public	NOUN
ajst-6290	178	8	is	be	AUX
ajst-6290	178	9	not	not	PART
ajst-6290	178	10	well	well	ADV
ajst-6290	178	11	informed	informed	ADJ
ajst-6290	178	12	about	about	ADP
ajst-6290	178	13	synthetic	synthetic	ADJ
ajst-6290	178	14	biology	biology	NOUN
ajst-6290	178	15	and	and	CCONJ
ajst-6290	178	16	is	be	AUX
ajst-6290	178	17	prone	prone	ADJ
ajst-6290	178	18	to	to	ADP
ajst-6290	178	19	panic	panic	NOUN
ajst-6290	178	20	and	and	CCONJ
ajst-6290	178	21	concern	concern	NOUN
ajst-6290	178	22	,	,	PUNCT
ajst-6290	178	23	thus	thus	ADV
ajst-6290	178	24	creating	create	VERB
ajst-6290	178	25	barriers	barrier	NOUN
ajst-6290	178	26	to	to	ADP
ajst-6290	178	27	the	the	DET
ajst-6290	178	28	diffusion	diffusion	NOUN
ajst-6290	178	29	and	and	CCONJ
ajst-6290	178	30	application	application	NOUN
ajst-6290	178	31	of	of	ADP
ajst-6290	178	32	the	the	DET
ajst-6290	178	33	technology	technology	NOUN
ajst-6290	178	34	.	.	PUNCT
ajst-6290	179	1	on	on	ADP
ajst-6290	179	2	the	the	DET
ajst-6290	179	3	other	other	ADJ
ajst-6290	179	4	hand	hand	NOUN
ajst-6290	179	5	,	,	PUNCT
ajst-6290	179	6	the	the	DET
ajst-6290	179	7	lack	lack	NOUN
ajst-6290	179	8	of	of	ADP
ajst-6290	179	9	unified	unified	ADJ
ajst-6290	179	10	planning	planning	NOUN
ajst-6290	179	11	and	and	CCONJ
ajst-6290	179	12	regulation	regulation	NOUN
ajst-6290	179	13	of	of	ADP
ajst-6290	179	14	synthetic	synthetic	ADJ
ajst-6290	179	15	biology	biology	NOUN
ajst-6290	179	16	among	among	ADP
ajst-6290	179	17	some	some	DET
ajst-6290	179	18	countries	country	NOUN
ajst-6290	179	19	and	and	CCONJ
ajst-6290	179	20	organizations	organization	NOUN
ajst-6290	179	21	has	have	AUX
ajst-6290	179	22	led	lead	VERB
ajst-6290	179	23	to	to	ADP
ajst-6290	179	24	restrictions	restriction	NOUN
ajst-6290	179	25	on	on	ADP
ajst-6290	179	26	the	the	DET
ajst-6290	179	27	application	application	NOUN
ajst-6290	179	28	and	and	CCONJ
ajst-6290	179	29	development	development	NOUN
ajst-6290	179	30	of	of	ADP
ajst-6290	179	31	the	the	DET
ajst-6290	179	32	technology	technology	NOUN
ajst-6290	179	33	in	in	ADP
ajst-6290	179	34	different	different	ADJ
ajst-6290	179	35	fields	field	NOUN
ajst-6290	179	36	.	.	PUNCT
ajst-6290	180	1	at	at	ADP
ajst-6290	180	2	the	the	DET
ajst-6290	180	3	same	same	ADJ
ajst-6290	180	4	time	time	NOUN
ajst-6290	180	5	,	,	PUNCT
ajst-6290	180	6	there	there	PRON
ajst-6290	180	7	are	be	VERB
ajst-6290	180	8	also	also	ADV
ajst-6290	180	9	some	some	DET
ajst-6290	180	10	ethical	ethical	ADJ
ajst-6290	180	11	and	and	CCONJ
ajst-6290	180	12	moral	moral	ADJ
ajst-6290	180	13	issues	issue	NOUN
ajst-6290	180	14	,	,	PUNCT
ajst-6290	180	15	such	such	ADJ
ajst-6290	180	16	as	as	ADP
ajst-6290	180	17	respect	respect	NOUN
ajst-6290	180	18	for	for	ADP
ajst-6290	180	19	life	life	NOUN
ajst-6290	180	20	and	and	CCONJ
ajst-6290	180	21	human	human	ADJ
ajst-6290	180	22	gene	gene	NOUN
ajst-6290	180	23	editing	editing	NOUN
ajst-6290	180	24	,	,	PUNCT
ajst-6290	180	25	which	which	PRON
ajst-6290	180	26	need	need	VERB
ajst-6290	180	27	sufficient	sufficient	ADJ
ajst-6290	180	28	attention	attention	NOUN
ajst-6290	180	29	and	and	CCONJ
ajst-6290	180	30	discussion	discussion	NOUN
ajst-6290	180	31	.	.	PUNCT
ajst-6290	181	1	5.2.3	5.2.3	X
ajst-6290	181	2	.	.	PUNCT
ajst-6290	181	3	market	market	NOUN
ajst-6290	181	4	and	and	CCONJ
ajst-6290	181	5	commercial	commercial	ADJ
ajst-6290	181	6	opportunities	opportunity	NOUN
ajst-6290	181	7	the	the	DET
ajst-6290	181	8	development	development	NOUN
ajst-6290	181	9	of	of	ADP
ajst-6290	181	10	synthetic	synthetic	ADJ
ajst-6290	181	11	biology	biology	NOUN
ajst-6290	181	12	also	also	ADV
ajst-6290	181	13	brings	bring	VERB
ajst-6290	181	14	great	great	ADJ
ajst-6290	181	15	opportunities	opportunity	NOUN
ajst-6290	181	16	for	for	ADP
ajst-6290	181	17	the	the	DET
ajst-6290	181	18	market	market	NOUN
ajst-6290	181	19	and	and	CCONJ
ajst-6290	181	20	business	business	NOUN
ajst-6290	181	21	.	.	PUNCT
ajst-6290	182	1	on	on	ADP
ajst-6290	182	2	the	the	DET
ajst-6290	182	3	one	one	NUM
ajst-6290	182	4	hand	hand	NOUN
ajst-6290	182	5	,	,	PUNCT
ajst-6290	182	6	the	the	DET
ajst-6290	182	7	technological	technological	ADJ
ajst-6290	182	8	application	application	NOUN
ajst-6290	182	9	of	of	ADP
ajst-6290	182	10	synthetic	synthetic	ADJ
ajst-6290	182	11	biology	biology	NOUN
ajst-6290	182	12	can	can	AUX
ajst-6290	182	13	help	help	VERB
ajst-6290	182	14	companies	company	NOUN
ajst-6290	182	15	improve	improve	VERB
ajst-6290	182	16	production	production	NOUN
ajst-6290	182	17	efficiency	efficiency	NOUN
ajst-6290	182	18	and	and	CCONJ
ajst-6290	182	19	product	product	NOUN
ajst-6290	182	20	quality	quality	NOUN
ajst-6290	182	21	,	,	PUNCT
ajst-6290	182	22	reduce	reduce	VERB
ajst-6290	182	23	costs	cost	NOUN
ajst-6290	182	24	and	and	CCONJ
ajst-6290	182	25	increase	increase	VERB
ajst-6290	182	26	competitiveness	competitiveness	NOUN
ajst-6290	182	27	.	.	PUNCT
ajst-6290	183	1	on	on	ADP
ajst-6290	183	2	the	the	DET
ajst-6290	183	3	other	other	ADJ
ajst-6290	183	4	hand	hand	NOUN
ajst-6290	183	5	,	,	PUNCT
ajst-6290	183	6	the	the	DET
ajst-6290	183	7	technological	technological	ADJ
ajst-6290	183	8	application	application	NOUN
ajst-6290	183	9	of	of	ADP
ajst-6290	183	10	synthetic	synthetic	ADJ
ajst-6290	183	11	biology	biology	NOUN
ajst-6290	183	12	can	can	AUX
ajst-6290	183	13	also	also	ADV
ajst-6290	183	14	help	help	VERB
ajst-6290	183	15	companies	company	NOUN
ajst-6290	183	16	develop	develop	VERB
ajst-6290	183	17	new	new	ADJ
ajst-6290	183	18	products	product	NOUN
ajst-6290	183	19	,	,	PUNCT
ajst-6290	183	20	open	open	VERB
ajst-6290	183	21	up	up	ADP
ajst-6290	183	22	new	new	ADJ
ajst-6290	183	23	markets	market	NOUN
ajst-6290	183	24	and	and	CCONJ
ajst-6290	183	25	expand	expand	VERB
ajst-6290	183	26	their	their	PRON
ajst-6290	183	27	business	business	NOUN
ajst-6290	183	28	fields	field	NOUN
ajst-6290	183	29	.	.	PUNCT
ajst-6290	184	1	at	at	ADP
ajst-6290	184	2	the	the	DET
ajst-6290	184	3	same	same	ADJ
ajst-6290	184	4	time	time	NOUN
ajst-6290	184	5	,	,	PUNCT
ajst-6290	184	6	as	as	ADP
ajst-6290	184	7	the	the	DET
ajst-6290	184	8	technology	technology	NOUN
ajst-6290	184	9	further	further	ADJ
ajst-6290	184	10	matures	mature	NOUN
ajst-6290	184	11	and	and	CCONJ
ajst-6290	184	12	is	be	AUX
ajst-6290	184	13	applied	apply	VERB
ajst-6290	184	14	,	,	PUNCT
ajst-6290	184	15	more	more	ADV
ajst-6290	184	16	innovative	innovative	ADJ
ajst-6290	184	17	enterprises	enterprise	NOUN
ajst-6290	184	18	and	and	CCONJ
ajst-6290	184	19	business	business	NOUN
ajst-6290	184	20	models	model	NOUN
ajst-6290	184	21	will	will	AUX
ajst-6290	184	22	emerge	emerge	VERB
ajst-6290	184	23	to	to	PART
ajst-6290	184	24	promote	promote	VERB
ajst-6290	184	25	the	the	DET
ajst-6290	184	26	rapid	rapid	ADJ
ajst-6290	184	27	promotion	promotion	NOUN
ajst-6290	184	28	and	and	CCONJ
ajst-6290	184	29	implementation	implementation	NOUN
ajst-6290	184	30	of	of	ADP
ajst-6290	184	31	the	the	DET
ajst-6290	184	32	technology	technology	NOUN
ajst-6290	184	33	.	.	PUNCT
ajst-6290	185	1	in	in	ADP
ajst-6290	185	2	general	general	ADJ
ajst-6290	185	3	,	,	PUNCT
ajst-6290	185	4	synthetic	synthetic	ADJ
ajst-6290	185	5	biology	biology	NOUN
ajst-6290	185	6	,	,	PUNCT
ajst-6290	185	7	as	as	ADP
ajst-6290	185	8	an	an	DET
ajst-6290	185	9	emerging	emerge	VERB
ajst-6290	185	10	interdisciplinary	interdisciplinary	ADJ
ajst-6290	185	11	discipline	discipline	NOUN
ajst-6290	185	12	,	,	PUNCT
ajst-6290	185	13	has	have	VERB
ajst-6290	185	14	great	great	ADJ
ajst-6290	185	15	potential	potential	NOUN
ajst-6290	185	16	for	for	ADP
ajst-6290	185	17	development	development	NOUN
ajst-6290	185	18	and	and	CCONJ
ajst-6290	185	19	broad	broad	ADJ
ajst-6290	185	20	application	application	NOUN
ajst-6290	185	21	prospects	prospect	NOUN
ajst-6290	185	22	.	.	PUNCT
ajst-6290	186	1	however	however	ADV
ajst-6290	186	2	,	,	PUNCT
ajst-6290	186	3	there	there	PRON
ajst-6290	186	4	are	be	VERB
ajst-6290	186	5	also	also	ADV
ajst-6290	186	6	ethical	ethical	ADJ
ajst-6290	186	7	,	,	PUNCT
ajst-6290	186	8	social	social	ADJ
ajst-6290	186	9	and	and	CCONJ
ajst-6290	186	10	policy	policy	NOUN
ajst-6290	186	11	challenges	challenge	NOUN
ajst-6290	186	12	,	,	PUNCT
ajst-6290	186	13	which	which	PRON
ajst-6290	186	14	need	need	VERB
ajst-6290	186	15	to	to	PART
ajst-6290	186	16	be	be	AUX
ajst-6290	186	17	widely	widely	ADV
ajst-6290	186	18	emphasized	emphasize	VERB
ajst-6290	186	19	and	and	CCONJ
ajst-6290	186	20	discussed	discuss	VERB
ajst-6290	186	21	.	.	PUNCT
ajst-6290	187	1	6	6	X
ajst-6290	187	2	.	.	X
ajst-6290	187	3	conclusion	conclusion	NOUN
ajst-6290	187	4	6.1	6.1	NUM
ajst-6290	187	5	.	.	PUNCT
ajst-6290	188	1	review	review	NOUN
ajst-6290	188	2	of	of	ADP
ajst-6290	188	3	the	the	DET
ajst-6290	188	4	development	development	NOUN
ajst-6290	188	5	of	of	ADP
ajst-6290	188	6	synthetic	synthetic	ADJ
ajst-6290	188	7	biology	biology	NOUN
ajst-6290	188	8	synthetic	synthetic	ADJ
ajst-6290	188	9	biology	biology	NOUN
ajst-6290	188	10	,	,	PUNCT
ajst-6290	188	11	as	as	ADP
ajst-6290	188	12	an	an	DET
ajst-6290	188	13	emerging	emerge	VERB
ajst-6290	188	14	discipline	discipline	NOUN
ajst-6290	188	15	,	,	PUNCT
ajst-6290	188	16	has	have	AUX
ajst-6290	188	17	had	have	VERB
ajst-6290	188	18	a	a	DET
ajst-6290	188	19	short	short	ADJ
ajst-6290	188	20	but	but	CCONJ
ajst-6290	188	21	turbulent	turbulent	ADJ
ajst-6290	188	22	history	history	NOUN
ajst-6290	188	23	of	of	ADP
ajst-6290	188	24	development	development	NOUN
ajst-6290	188	25	.	.	PUNCT
ajst-6290	189	1	since	since	SCONJ
ajst-6290	189	2	its	its	PRON
ajst-6290	189	3	rise	rise	NOUN
ajst-6290	189	4	in	in	ADP
ajst-6290	189	5	the	the	DET
ajst-6290	189	6	early	early	ADJ
ajst-6290	189	7	2000s	2000s	NUM
ajst-6290	189	8	,	,	PUNCT
ajst-6290	189	9	it	it	PRON
ajst-6290	189	10	has	have	AUX
ajst-6290	189	11	been	be	AUX
ajst-6290	189	12	developing	develop	VERB
ajst-6290	189	13	rapidly	rapidly	ADV
ajst-6290	189	14	in	in	ADP
ajst-6290	189	15	recent	recent	ADJ
ajst-6290	189	16	years	year	NOUN
ajst-6290	189	17	,	,	PUNCT
ajst-6290	189	18	attracting	attract	VERB
ajst-6290	189	19	the	the	DET
ajst-6290	189	20	participation	participation	NOUN
ajst-6290	189	21	of	of	ADP
ajst-6290	189	22	a	a	DET
ajst-6290	189	23	large	large	ADJ
ajst-6290	189	24	number	number	NOUN
ajst-6290	189	25	of	of	ADP
ajst-6290	189	26	research	research	NOUN
ajst-6290	189	27	institutions	institution	NOUN
ajst-6290	189	28	and	and	CCONJ
ajst-6290	189	29	enterprises	enterprise	NOUN
ajst-6290	189	30	,	,	PUNCT
ajst-6290	189	31	and	and	CCONJ
ajst-6290	189	32	has	have	AUX
ajst-6290	189	33	become	become	VERB
ajst-6290	189	34	another	another	DET
ajst-6290	189	35	technology	technology	NOUN
ajst-6290	189	36	and	and	CCONJ
ajst-6290	189	37	discipline	discipline	NOUN
ajst-6290	189	38	field	field	NOUN
ajst-6290	189	39	that	that	PRON
ajst-6290	189	40	has	have	AUX
ajst-6290	189	41	overturned	overturn	VERB
ajst-6290	189	42	traditional	traditional	ADJ
ajst-6290	189	43	human	human	ADJ
ajst-6290	189	44	perceptions	perception	NOUN
ajst-6290	189	45	after	after	ADP
ajst-6290	189	46	computer	computer	NOUN
ajst-6290	189	47	science	science	NOUN
ajst-6290	189	48	,	,	PUNCT
ajst-6290	189	49	information	information	NOUN
ajst-6290	189	50	technology	technology	NOUN
ajst-6290	189	51	and	and	CCONJ
ajst-6290	189	52	biotechnology	biotechnology	NOUN
ajst-6290	189	53	.	.	PUNCT
ajst-6290	190	1	6.2	6.2	NUM
ajst-6290	190	2	.	.	PUNCT
ajst-6290	191	1	current	current	ADJ
ajst-6290	191	2	status	status	NOUN
ajst-6290	191	3	and	and	CCONJ
ajst-6290	191	4	future	future	ADJ
ajst-6290	191	5	development	development	NOUN
ajst-6290	191	6	prospects	prospect	NOUN
ajst-6290	191	7	of	of	ADP
ajst-6290	191	8	synthetic	synthetic	ADJ
ajst-6290	191	9	biology	biology	NOUN
ajst-6290	191	10	in	in	ADP
ajst-6290	191	11	just	just	ADV
ajst-6290	191	12	a	a	DET
ajst-6290	191	13	few	few	ADJ
ajst-6290	191	14	decades	decade	NOUN
ajst-6290	191	15	,	,	PUNCT
ajst-6290	191	16	synthetic	synthetic	ADJ
ajst-6290	191	17	biology	biology	NOUN
ajst-6290	191	18	has	have	AUX
ajst-6290	191	19	achieved	achieve	VERB
ajst-6290	191	20	a	a	DET
ajst-6290	191	21	leapfrog	leapfrog	ADJ
ajst-6290	191	22	development	development	NOUN
ajst-6290	191	23	from	from	ADP
ajst-6290	191	24	basic	basic	ADJ
ajst-6290	191	25	research	research	NOUN
ajst-6290	191	26	to	to	ADP
ajst-6290	191	27	application	application	NOUN
ajst-6290	191	28	development	development	NOUN
ajst-6290	191	29	,	,	PUNCT
ajst-6290	191	30	promoting	promote	VERB
ajst-6290	191	31	the	the	DET
ajst-6290	191	32	development	development	NOUN
ajst-6290	191	33	of	of	ADP
ajst-6290	191	34	life	life	NOUN
ajst-6290	191	35	science	science	NOUN
ajst-6290	191	36	,	,	PUNCT
ajst-6290	191	37	engineering	engineering	NOUN
ajst-6290	191	38	,	,	PUNCT
ajst-6290	191	39	information	information	NOUN
ajst-6290	191	40	science	science	NOUN
ajst-6290	191	41	and	and	CCONJ
ajst-6290	191	42	other	other	ADJ
ajst-6290	191	43	multidisciplinary	multidisciplinary	ADJ
ajst-6290	191	44	fields	field	NOUN
ajst-6290	191	45	,	,	PUNCT
ajst-6290	191	46	and	and	CCONJ
ajst-6290	191	47	becoming	become	VERB
ajst-6290	191	48	an	an	DET
ajst-6290	191	49	important	important	ADJ
ajst-6290	191	50	part	part	NOUN
ajst-6290	191	51	of	of	ADP
ajst-6290	191	52	the	the	DET
ajst-6290	191	53	scientific	scientific	ADJ
ajst-6290	191	54	and	and	CCONJ
ajst-6290	191	55	technological	technological	ADJ
ajst-6290	191	56	revolution	revolution	NOUN
ajst-6290	191	57	in	in	ADP
ajst-6290	191	58	the	the	DET
ajst-6290	191	59	new	new	ADJ
ajst-6290	191	60	era	era	NOUN
ajst-6290	191	61	.	.	PUNCT
ajst-6290	192	1	in	in	ADP
ajst-6290	192	2	the	the	DET
ajst-6290	192	3	future	future	NOUN
ajst-6290	192	4	,	,	PUNCT
ajst-6290	192	5	with	with	ADP
ajst-6290	192	6	the	the	DET
ajst-6290	192	7	continuous	continuous	ADJ
ajst-6290	192	8	innovation	innovation	NOUN
ajst-6290	192	9	of	of	ADP
ajst-6290	192	10	technology	technology	NOUN
ajst-6290	192	11	and	and	CCONJ
ajst-6290	192	12	the	the	DET
ajst-6290	192	13	expansion	expansion	NOUN
ajst-6290	192	14	of	of	ADP
ajst-6290	192	15	application	application	NOUN
ajst-6290	192	16	fields	field	NOUN
ajst-6290	192	17	,	,	PUNCT
ajst-6290	192	18	synthetic	synthetic	ADJ
ajst-6290	192	19	biology	biology	NOUN
ajst-6290	192	20	will	will	AUX
ajst-6290	192	21	continue	continue	VERB
ajst-6290	192	22	to	to	PART
ajst-6290	192	23	play	play	VERB
ajst-6290	192	24	an	an	DET
ajst-6290	192	25	important	important	ADJ
ajst-6290	192	26	role	role	NOUN
ajst-6290	192	27	in	in	ADP
ajst-6290	192	28	medicine	medicine	NOUN
ajst-6290	192	29	,	,	PUNCT
ajst-6290	192	30	industry	industry	NOUN
ajst-6290	192	31	,	,	PUNCT
ajst-6290	192	32	agriculture	agriculture	NOUN
ajst-6290	192	33	,	,	PUNCT
ajst-6290	192	34	environmental	environmental	ADJ
ajst-6290	192	35	protection	protection	NOUN
ajst-6290	192	36	and	and	CCONJ
ajst-6290	192	37	other	other	ADJ
ajst-6290	192	38	fields	field	NOUN
ajst-6290	192	39	,	,	PUNCT
ajst-6290	192	40	bringing	bring	VERB
ajst-6290	192	41	more	more	ADJ
ajst-6290	192	42	benefits	benefit	NOUN
ajst-6290	192	43	to	to	ADP
ajst-6290	192	44	human	human	ADJ
ajst-6290	192	45	production	production	NOUN
ajst-6290	192	46	and	and	CCONJ
ajst-6290	192	47	health	health	NOUN
ajst-6290	192	48	.	.	PUNCT
ajst-6290	193	1	100	100	NUM
ajst-6290	193	2	6.3	6.3	NUM
ajst-6290	193	3	.	.	PUNCT
ajst-6290	194	1	the	the	DET
ajst-6290	194	2	importance	importance	NOUN
ajst-6290	194	3	and	and	CCONJ
ajst-6290	194	4	impact	impact	NOUN
ajst-6290	194	5	of	of	ADP
ajst-6290	194	6	synthetic	synthetic	ADJ
ajst-6290	194	7	biology	biology	NOUN
ajst-6290	194	8	on	on	ADP
ajst-6290	194	9	society	society	NOUN
ajst-6290	194	10	and	and	CCONJ
ajst-6290	194	11	ecosystem	ecosystem	NOUN
ajst-6290	194	12	6.3.1	6.3.1	NUM
ajst-6290	194	13	.	.	PUNCT
ajst-6290	195	1	synthetic	synthetic	ADJ
ajst-6290	195	2	biology	biology	NOUN
ajst-6290	195	3	's	's	PART
ajst-6290	195	4	contribution	contribution	NOUN
ajst-6290	195	5	to	to	ADP
ajst-6290	195	6	scientific	scientific	ADJ
ajst-6290	195	7	and	and	CCONJ
ajst-6290	195	8	technological	technological	ADJ
ajst-6290	195	9	progress	progress	NOUN
ajst-6290	195	10	the	the	DET
ajst-6290	195	11	rapid	rapid	ADJ
ajst-6290	195	12	development	development	NOUN
ajst-6290	195	13	of	of	ADP
ajst-6290	195	14	synthetic	synthetic	ADJ
ajst-6290	195	15	biology	biology	NOUN
ajst-6290	195	16	has	have	AUX
ajst-6290	195	17	promoted	promote	VERB
ajst-6290	195	18	the	the	DET
ajst-6290	195	19	cross	cross	NOUN
ajst-6290	195	20	-	-	NOUN
ajst-6290	195	21	fertilization	fertilization	NOUN
ajst-6290	195	22	of	of	ADP
ajst-6290	195	23	many	many	ADJ
ajst-6290	195	24	fields	field	NOUN
ajst-6290	195	25	,	,	PUNCT
ajst-6290	195	26	such	such	ADJ
ajst-6290	195	27	as	as	ADP
ajst-6290	195	28	life	life	NOUN
ajst-6290	195	29	science	science	NOUN
ajst-6290	195	30	,	,	PUNCT
ajst-6290	195	31	computer	computer	NOUN
ajst-6290	195	32	science	science	NOUN
ajst-6290	195	33	,	,	PUNCT
ajst-6290	195	34	physics	physics	NOUN
ajst-6290	195	35	,	,	PUNCT
ajst-6290	195	36	and	and	CCONJ
ajst-6290	195	37	chemistry	chemistry	NOUN
ajst-6290	195	38	,	,	PUNCT
ajst-6290	195	39	and	and	CCONJ
ajst-6290	195	40	has	have	AUX
ajst-6290	195	41	facilitated	facilitate	VERB
ajst-6290	195	42	the	the	DET
ajst-6290	195	43	progress	progress	NOUN
ajst-6290	195	44	of	of	ADP
ajst-6290	195	45	science	science	NOUN
ajst-6290	195	46	and	and	CCONJ
ajst-6290	195	47	technology	technology	NOUN
ajst-6290	195	48	.	.	PUNCT
ajst-6290	196	1	synthetic	synthetic	ADJ
ajst-6290	196	2	biology	biology	NOUN
ajst-6290	196	3	has	have	AUX
ajst-6290	196	4	provided	provide	VERB
ajst-6290	196	5	us	we	PRON
ajst-6290	196	6	with	with	ADP
ajst-6290	196	7	new	new	ADJ
ajst-6290	196	8	perspectives	perspective	NOUN
ajst-6290	196	9	and	and	CCONJ
ajst-6290	196	10	tools	tool	NOUN
ajst-6290	196	11	to	to	PART
ajst-6290	196	12	deeply	deeply	ADV
ajst-6290	196	13	understand	understand	VERB
ajst-6290	196	14	the	the	DET
ajst-6290	196	15	nature	nature	NOUN
ajst-6290	196	16	and	and	CCONJ
ajst-6290	196	17	laws	law	NOUN
ajst-6290	196	18	of	of	ADP
ajst-6290	196	19	living	living	NOUN
ajst-6290	196	20	systems	system	NOUN
ajst-6290	196	21	,	,	PUNCT
ajst-6290	196	22	as	as	ADV
ajst-6290	196	23	well	well	ADV
ajst-6290	196	24	as	as	ADP
ajst-6290	196	25	new	new	ADJ
ajst-6290	196	26	ideas	idea	NOUN
ajst-6290	196	27	and	and	CCONJ
ajst-6290	196	28	methods	method	NOUN
ajst-6290	196	29	to	to	PART
ajst-6290	196	30	solve	solve	VERB
ajst-6290	196	31	more	more	ADV
ajst-6290	196	32	scientific	scientific	ADJ
ajst-6290	196	33	and	and	CCONJ
ajst-6290	196	34	social	social	ADJ
ajst-6290	196	35	problems	problem	NOUN
ajst-6290	196	36	.	.	PUNCT
ajst-6290	197	1	6.3.2	6.3.2	X
ajst-6290	197	2	.	.	PUNCT
ajst-6290	198	1	impact	impact	NOUN
ajst-6290	198	2	of	of	ADP
ajst-6290	198	3	synthetic	synthetic	ADJ
ajst-6290	198	4	biology	biology	NOUN
ajst-6290	198	5	on	on	ADP
ajst-6290	198	6	economic	economic	ADJ
ajst-6290	198	7	and	and	CCONJ
ajst-6290	198	8	industrial	industrial	ADJ
ajst-6290	198	9	development	development	NOUN
ajst-6290	198	10	the	the	DET
ajst-6290	198	11	rapid	rapid	ADJ
ajst-6290	198	12	development	development	NOUN
ajst-6290	198	13	of	of	ADP
ajst-6290	198	14	synthetic	synthetic	ADJ
ajst-6290	198	15	biology	biology	NOUN
ajst-6290	198	16	has	have	AUX
ajst-6290	198	17	led	lead	VERB
ajst-6290	198	18	to	to	ADP
ajst-6290	198	19	the	the	DET
ajst-6290	198	20	emergence	emergence	NOUN
ajst-6290	198	21	of	of	ADP
ajst-6290	198	22	many	many	ADJ
ajst-6290	198	23	new	new	ADJ
ajst-6290	198	24	industries	industry	NOUN
ajst-6290	198	25	and	and	CCONJ
ajst-6290	198	26	technologies	technology	NOUN
ajst-6290	198	27	,	,	PUNCT
ajst-6290	198	28	such	such	ADJ
ajst-6290	198	29	as	as	ADP
ajst-6290	198	30	synthetic	synthetic	ADJ
ajst-6290	198	31	biology	biology	NOUN
ajst-6290	198	32	drugs	drug	NOUN
ajst-6290	198	33	,	,	PUNCT
ajst-6290	198	34	biomanufacturing	biomanufacturing	NOUN
ajst-6290	198	35	,	,	PUNCT
ajst-6290	198	36	and	and	CCONJ
ajst-6290	198	37	bioenergy	bioenergy	NOUN
ajst-6290	198	38	.	.	PUNCT
ajst-6290	199	1	the	the	DET
ajst-6290	199	2	development	development	NOUN
ajst-6290	199	3	of	of	ADP
ajst-6290	199	4	synthetic	synthetic	ADJ
ajst-6290	199	5	biology	biology	NOUN
ajst-6290	199	6	also	also	ADV
ajst-6290	199	7	provides	provide	VERB
ajst-6290	199	8	more	more	ADJ
ajst-6290	199	9	economic	economic	ADJ
ajst-6290	199	10	growth	growth	NOUN
ajst-6290	199	11	points	point	NOUN
ajst-6290	199	12	and	and	CCONJ
ajst-6290	199	13	innovation	innovation	NOUN
ajst-6290	199	14	drivers	driver	NOUN
ajst-6290	199	15	for	for	ADP
ajst-6290	199	16	the	the	DET
ajst-6290	199	17	sustainable	sustainable	ADJ
ajst-6290	199	18	development	development	NOUN
ajst-6290	199	19	of	of	ADP
ajst-6290	199	20	society	society	NOUN
ajst-6290	199	21	.	.	PUNCT
ajst-6290	200	1	6.3.3	6.3.3	X
ajst-6290	200	2	.	.	PUNCT
ajst-6290	201	1	challenges	challenge	NOUN
ajst-6290	201	2	and	and	CCONJ
ajst-6290	201	3	opportunities	opportunity	NOUN
ajst-6290	201	4	of	of	ADP
ajst-6290	201	5	synthetic	synthetic	ADJ
ajst-6290	201	6	biology	biology	NOUN
ajst-6290	201	7	for	for	ADP
ajst-6290	201	8	human	human	ADJ
ajst-6290	201	9	and	and	CCONJ
ajst-6290	201	10	ecological	ecological	ADJ
ajst-6290	201	11	environment	environment	NOUN
ajst-6290	201	12	the	the	DET
ajst-6290	201	13	rapid	rapid	ADJ
ajst-6290	201	14	development	development	NOUN
ajst-6290	201	15	of	of	ADP
ajst-6290	201	16	synthetic	synthetic	ADJ
ajst-6290	201	17	biology	biology	NOUN
ajst-6290	201	18	has	have	AUX
ajst-6290	201	19	also	also	ADV
ajst-6290	201	20	brought	bring	VERB
ajst-6290	201	21	some	some	DET
ajst-6290	201	22	new	new	ADJ
ajst-6290	201	23	challenges	challenge	NOUN
ajst-6290	201	24	and	and	CCONJ
ajst-6290	201	25	opportunities	opportunity	NOUN
ajst-6290	201	26	.	.	PUNCT
ajst-6290	202	1	the	the	DET
ajst-6290	202	2	application	application	NOUN
ajst-6290	202	3	of	of	ADP
ajst-6290	202	4	synthetic	synthetic	ADJ
ajst-6290	202	5	biology	biology	NOUN
ajst-6290	202	6	technology	technology	NOUN
ajst-6290	202	7	needs	need	VERB
ajst-6290	202	8	to	to	PART
ajst-6290	202	9	take	take	VERB
ajst-6290	202	10	into	into	ADP
ajst-6290	202	11	account	account	NOUN
ajst-6290	202	12	the	the	DET
ajst-6290	202	13	safety	safety	NOUN
ajst-6290	202	14	and	and	CCONJ
ajst-6290	202	15	interests	interest	NOUN
ajst-6290	202	16	of	of	ADP
ajst-6290	202	17	human	human	ADJ
ajst-6290	202	18	and	and	CCONJ
ajst-6290	202	19	ecological	ecological	ADJ
ajst-6290	202	20	environment	environment	NOUN
ajst-6290	202	21	,	,	PUNCT
ajst-6290	202	22	and	and	CCONJ
ajst-6290	202	23	needs	need	VERB
ajst-6290	202	24	to	to	PART
ajst-6290	202	25	follow	follow	VERB
ajst-6290	202	26	scientific	scientific	ADJ
ajst-6290	202	27	,	,	PUNCT
ajst-6290	202	28	ethical	ethical	ADJ
ajst-6290	202	29	and	and	CCONJ
ajst-6290	202	30	moral	moral	ADJ
ajst-6290	202	31	standards	standard	NOUN
ajst-6290	202	32	.	.	PUNCT
ajst-6290	203	1	at	at	ADP
ajst-6290	203	2	the	the	DET
ajst-6290	203	3	same	same	ADJ
ajst-6290	203	4	time	time	NOUN
ajst-6290	203	5	,	,	PUNCT
ajst-6290	203	6	synthetic	synthetic	ADJ
ajst-6290	203	7	biology	biology	NOUN
ajst-6290	203	8	also	also	ADV
ajst-6290	203	9	provides	provide	VERB
ajst-6290	203	10	new	new	ADJ
ajst-6290	203	11	opportunities	opportunity	NOUN
ajst-6290	203	12	and	and	CCONJ
ajst-6290	203	13	solutions	solution	NOUN
ajst-6290	203	14	to	to	ADP
ajst-6290	203	15	many	many	ADJ
ajst-6290	203	16	problems	problem	NOUN
ajst-6290	203	17	facing	face	VERB
ajst-6290	203	18	humans	human	NOUN
ajst-6290	203	19	and	and	CCONJ
ajst-6290	203	20	the	the	DET
ajst-6290	203	21	ecological	ecological	ADJ
ajst-6290	203	22	environment	environment	NOUN
ajst-6290	203	23	.	.	PUNCT
ajst-6290	204	1	in	in	ADP
ajst-6290	204	2	conclusion	conclusion	NOUN
ajst-6290	204	3	,	,	PUNCT
ajst-6290	204	4	synthetic	synthetic	ADJ
ajst-6290	204	5	biology	biology	NOUN
ajst-6290	204	6	is	be	AUX
ajst-6290	204	7	a	a	DET
ajst-6290	204	8	rapidly	rapidly	ADV
ajst-6290	204	9	evolving	evolve	VERB
ajst-6290	204	10	discipline	discipline	NOUN
ajst-6290	204	11	that	that	PRON
ajst-6290	204	12	provides	provide	VERB
ajst-6290	204	13	us	we	PRON
ajst-6290	204	14	with	with	ADP
ajst-6290	204	15	many	many	ADJ
ajst-6290	204	16	new	new	ADJ
ajst-6290	204	17	opportunities	opportunity	NOUN
ajst-6290	204	18	and	and	CCONJ
ajst-6290	204	19	challenges	challenge	NOUN
ajst-6290	204	20	.	.	PUNCT
ajst-6290	205	1	we	we	PRON
ajst-6290	205	2	expect	expect	VERB
ajst-6290	205	3	that	that	SCONJ
ajst-6290	205	4	synthetic	synthetic	ADJ
ajst-6290	205	5	biology	biology	NOUN
ajst-6290	205	6	will	will	AUX
ajst-6290	205	7	continue	continue	VERB
ajst-6290	205	8	to	to	PART
ajst-6290	205	9	develop	develop	VERB
ajst-6290	205	10	at	at	ADP
ajst-6290	205	11	a	a	DET
ajst-6290	205	12	high	high	ADJ
ajst-6290	205	13	rate	rate	NOUN
ajst-6290	205	14	in	in	ADP
ajst-6290	205	15	the	the	DET
ajst-6290	205	16	future	future	NOUN
ajst-6290	205	17	,	,	PUNCT
ajst-6290	205	18	providing	provide	VERB
ajst-6290	205	19	us	we	PRON
ajst-6290	205	20	with	with	ADP
ajst-6290	205	21	more	more	ADJ
ajst-6290	205	22	real	real	ADJ
ajst-6290	205	23	-	-	PUNCT
ajst-6290	205	24	world	world	NOUN
ajst-6290	205	25	solutions	solution	NOUN
ajst-6290	205	26	to	to	ADP
ajst-6290	205	27	problems	problem	NOUN
ajst-6290	205	28	and	and	CCONJ
ajst-6290	205	29	a	a	DET
ajst-6290	205	30	deeper	deep	ADJ
ajst-6290	205	31	understanding	understanding	NOUN
ajst-6290	205	32	of	of	ADP
ajst-6290	205	33	basic	basic	ADJ
ajst-6290	205	34	research	research	NOUN
ajst-6290	205	35	in	in	ADP
ajst-6290	205	36	biology	biology	NOUN
ajst-6290	205	37	.	.	PUNCT
ajst-6290	206	1	references	reference	NOUN
ajst-6290	206	2	[	[	X
ajst-6290	206	3	1	1	NUM
ajst-6290	206	4	]	]	PUNCT
ajst-6290	206	5	berg	berg	PROPN
ajst-6290	206	6	,	,	PUNCT
ajst-6290	206	7	p.	p.	PROPN
ajst-6290	206	8	,	,	PUNCT
ajst-6290	206	9	&	&	CCONJ
ajst-6290	206	10	cohen	cohen	PROPN
ajst-6290	206	11	,	,	PUNCT
ajst-6290	206	12	s.	s.	PROPN
ajst-6290	206	13	n.	n.	PROPN
ajst-6290	206	14	(	(	PUNCT
ajst-6290	206	15	1972	1972	NUM
ajst-6290	206	16	)	)	PUNCT
ajst-6290	206	17	.	.	PUNCT
ajst-6290	207	1	some	some	DET
ajst-6290	207	2	recombinant	recombinant	ADJ
ajst-6290	207	3	dna	dna	NOUN
ajst-6290	207	4	molecules	molecule	NOUN
ajst-6290	207	5	derived	derive	VERB
ajst-6290	207	6	from	from	ADP
ajst-6290	207	7	the	the	DET
ajst-6290	207	8	joining	joining	NOUN
ajst-6290	207	9	of	of	ADP
ajst-6290	207	10	dna	dna	PROPN
ajst-6290	207	11	fragments	fragment	NOUN
ajst-6290	207	12	from	from	ADP
ajst-6290	207	13	different	different	ADJ
ajst-6290	207	14	sources	source	NOUN
ajst-6290	207	15	.	.	PUNCT
ajst-6290	208	1	proceedings	proceeding	NOUN
ajst-6290	208	2	of	of	ADP
ajst-6290	208	3	the	the	DET
ajst-6290	208	4	national	national	PROPN
ajst-6290	208	5	academy	academy	PROPN
ajst-6290	208	6	of	of	ADP
ajst-6290	208	7	sciences	sciences	PROPN
ajst-6290	208	8	of	of	ADP
ajst-6290	208	9	the	the	DET
ajst-6290	208	10	united	united	PROPN
ajst-6290	208	11	states	states	PROPN
ajst-6290	208	12	of	of	ADP
ajst-6290	208	13	america	america	PROPN
ajst-6290	208	14	,	,	PUNCT
ajst-6290	208	15	69(12	69(12	NOUN
ajst-6290	208	16	)	)	PUNCT
ajst-6290	208	17	,	,	PUNCT
ajst-6290	208	18	3440	3440	NUM
ajst-6290	208	19	-	-	SYM
ajst-6290	208	20	3444	3444	NUM
ajst-6290	208	21	.	.	PUNCT
ajst-6290	209	1	[	[	X
ajst-6290	209	2	2	2	NUM
ajst-6290	209	3	]	]	X
ajst-6290	209	4	berg	berg	PROPN
ajst-6290	209	5	p	p	X
ajst-6290	209	6	,	,	PUNCT
ajst-6290	209	7	baltimore	baltimore	PROPN
ajst-6290	209	8	d	d	PROPN
ajst-6290	209	9	,	,	PUNCT
ajst-6290	209	10	boyer	boyer	PROPN
ajst-6290	209	11	hw	hw	PROPN
ajst-6290	209	12	,	,	PUNCT
ajst-6290	209	13	et	et	PROPN
ajst-6290	209	14	al	al	PROPN
ajst-6290	209	15	.	.	PUNCT
ajst-6290	209	16	potential	potential	ADJ
ajst-6290	209	17	biohazards	biohazard	NOUN
ajst-6290	209	18	of	of	ADP
ajst-6290	209	19	recombinant	recombinant	ADJ
ajst-6290	209	20	dna	dna	PROPN
ajst-6290	209	21	molecules[j	molecules[j	PROPN
ajst-6290	209	22	]	]	PUNCT
ajst-6290	209	23	.	.	PUNCT
ajst-6290	210	1	science	science	NOUN
ajst-6290	210	2	,	,	PUNCT
ajst-6290	210	3	1974	1974	NUM
ajst-6290	210	4	,	,	PUNCT
ajst-6290	210	5	185(4148	185(4148	NUM
ajst-6290	210	6	):	):	PUNCT
ajst-6290	210	7	303	303	NUM
ajst-6290	210	8	-	-	SYM
ajst-6290	210	9	306	306	NUM
ajst-6290	210	10	.	.	PUNCT
ajst-6290	211	1	[	[	X
ajst-6290	211	2	3	3	X
ajst-6290	211	3	]	]	X
ajst-6290	211	4	kent	kent	PROPN
ajst-6290	211	5	sb	sb	PROPN
ajst-6290	211	6	,	,	PUNCT
ajst-6290	211	7	hood	hood	NOUN
ajst-6290	211	8	le	le	X
ajst-6290	211	9	.	.	PUNCT
ajst-6290	212	1	chemistry	chemistry	NOUN
ajst-6290	212	2	of	of	ADP
ajst-6290	212	3	peptide	peptide	ADJ
ajst-6290	212	4	synthesis[j	synthesis[j	PROPN
ajst-6290	212	5	]	]	PUNCT
ajst-6290	212	6	.	.	PUNCT
ajst-6290	213	1	annu	annu	PROPN
ajst-6290	213	2	rev	rev	VERB
ajst-6290	213	3	biochem	biochem	PROPN
ajst-6290	213	4	,	,	PUNCT
ajst-6290	213	5	1992	1992	NUM
ajst-6290	213	6	,	,	PUNCT
ajst-6290	213	7	61(1	61(1	NOUN
ajst-6290	213	8	):	):	PUNCT
ajst-6290	213	9	397	397	NUM
ajst-6290	213	10	-	-	SYM
ajst-6290	213	11	416	416	NUM
ajst-6290	213	12	.	.	PUNCT
ajst-6290	214	1	[	[	X
ajst-6290	214	2	4	4	X
ajst-6290	214	3	]	]	PUNCT
ajst-6290	214	4	ptashne	ptashne	PROPN
ajst-6290	214	5	m.	m.	VERB
ajst-6290	214	6	a	a	DET
ajst-6290	214	7	genetic	genetic	ADJ
ajst-6290	214	8	switch	switch	NOUN
ajst-6290	214	9	:	:	PUNCT
ajst-6290	214	10	phage	phage	NOUN
ajst-6290	214	11	λ	λ	X
ajst-6290	214	12	revisited[m	revisited[m	X
ajst-6290	214	13	]	]	PUNCT
ajst-6290	214	14	.	.	PUNCT
ajst-6290	215	1	cold	cold	ADJ
ajst-6290	215	2	spring	spring	PROPN
ajst-6290	215	3	harbor	harbor	PROPN
ajst-6290	215	4	laboratory	laboratory	PROPN
ajst-6290	215	5	press	press	PROPN
ajst-6290	215	6	,	,	PUNCT
ajst-6290	215	7	2004	2004	NUM
ajst-6290	215	8	.	.	PUNCT
ajst-6290	216	1	[	[	X
ajst-6290	216	2	5	5	NUM
ajst-6290	216	3	]	]	X
ajst-6290	216	4	boyer	boyer	PROPN
ajst-6290	216	5	,	,	PUNCT
ajst-6290	216	6	h.	h.	PROPN
ajst-6290	216	7	w.	w.	PROPN
ajst-6290	216	8	,	,	PUNCT
ajst-6290	216	9	&	&	CCONJ
ajst-6290	216	10	cohen	cohen	PROPN
ajst-6290	216	11	,	,	PUNCT
ajst-6290	216	12	s.	s.	PROPN
ajst-6290	216	13	n.	n.	PROPN
ajst-6290	216	14	(	(	PUNCT
ajst-6290	216	15	1973	1973	NUM
ajst-6290	216	16	)	)	PUNCT
ajst-6290	216	17	.	.	PUNCT
ajst-6290	217	1	dna	dna	PROPN
ajst-6290	217	2	restriction	restriction	NOUN
ajst-6290	217	3	and	and	CCONJ
ajst-6290	217	4	modification	modification	NOUN
ajst-6290	217	5	mechanisms	mechanism	NOUN
ajst-6290	217	6	in	in	ADP
ajst-6290	217	7	bacteria	bacteria	NOUN
ajst-6290	217	8	.	.	PUNCT
ajst-6290	218	1	annual	annual	ADJ
ajst-6290	218	2	review	review	NOUN
ajst-6290	218	3	of	of	ADP
ajst-6290	218	4	microbiology	microbiology	NOUN
ajst-6290	218	5	,	,	PUNCT
ajst-6290	218	6	27(1	27(1	NUM
ajst-6290	218	7	)	)	PUNCT
ajst-6290	218	8	,	,	PUNCT
ajst-6290	218	9	115–138	115–138	NUM
ajst-6290	218	10	.	.	PUNCT
ajst-6290	219	1	[	[	X
ajst-6290	219	2	6	6	NUM
ajst-6290	219	3	]	]	X
ajst-6290	219	4	cohen	cohen	PROPN
ajst-6290	219	5	,	,	PUNCT
ajst-6290	219	6	s.	s.	PROPN
ajst-6290	219	7	n.	n.	PROPN
ajst-6290	219	8	(	(	PUNCT
ajst-6290	219	9	1973	1973	NUM
ajst-6290	219	10	)	)	PUNCT
ajst-6290	219	11	.	.	PUNCT
ajst-6290	220	1	dna	dna	PROPN
ajst-6290	220	2	cloning	cloning	NOUN
ajst-6290	220	3	:	:	PUNCT
ajst-6290	220	4	a	a	DET
ajst-6290	220	5	personal	personal	ADJ
ajst-6290	220	6	view	view	NOUN
ajst-6290	220	7	after	after	ADP
ajst-6290	220	8	40	40	NUM
ajst-6290	220	9	years	year	NOUN
ajst-6290	220	10	.	.	PUNCT
ajst-6290	221	1	proceedings	proceeding	NOUN
ajst-6290	221	2	of	of	ADP
ajst-6290	221	3	the	the	DET
ajst-6290	221	4	national	national	PROPN
ajst-6290	221	5	academy	academy	PROPN
ajst-6290	221	6	of	of	ADP
ajst-6290	221	7	sciences	sciences	PROPN
ajst-6290	221	8	of	of	ADP
ajst-6290	221	9	the	the	DET
ajst-6290	221	10	united	united	PROPN
ajst-6290	221	11	states	states	PROPN
ajst-6290	221	12	of	of	ADP
ajst-6290	221	13	america	america	PROPN
ajst-6290	221	14	,	,	PUNCT
ajst-6290	221	15	110(39	110(39	NUM
ajst-6290	221	16	)	)	PUNCT
ajst-6290	221	17	,	,	PUNCT
ajst-6290	221	18	15521–15529	15521–15529	NUM
ajst-6290	221	19	.	.	PUNCT
ajst-6290	222	1	[	[	X
ajst-6290	222	2	7	7	NUM
ajst-6290	222	3	]	]	X
ajst-6290	222	4	lederberg	lederberg	PROPN
ajst-6290	222	5	,	,	PUNCT
ajst-6290	222	6	j.	j.	PROPN
ajst-6290	222	7	and	and	CCONJ
ajst-6290	222	8	e.	e.	PROPN
ajst-6290	222	9	l.	l.	PROPN
ajst-6290	222	10	tatum	tatum	PROPN
ajst-6290	222	11	.	.	PUNCT
ajst-6290	223	1	"	"	PUNCT
ajst-6290	223	2	gene	gene	NOUN
ajst-6290	223	3	recombination	recombination	NOUN
ajst-6290	223	4	in	in	ADP
ajst-6290	223	5	escherichia	escherichia	NOUN
ajst-6290	223	6	coli	coli	NOUN
ajst-6290	223	7	.	.	PUNCT
ajst-6290	223	8	"	"	PUNCT
ajst-6290	224	1	nature	nature	NOUN
ajst-6290	224	2	,	,	PUNCT
ajst-6290	224	3	vol	vol	NOUN
ajst-6290	224	4	.	.	PROPN
ajst-6290	224	5	158	158	NUM
ajst-6290	224	6	,	,	PUNCT
ajst-6290	224	7	no	no	INTJ
ajst-6290	224	8	.	.	NOUN
ajst-6290	224	9	4016	4016	NUM
ajst-6290	224	10	,	,	PUNCT
ajst-6290	224	11	1946	1946	NUM
ajst-6290	224	12	,	,	PUNCT
ajst-6290	224	13	pp	pp	ADJ
ajst-6290	224	14	.	.	PUNCT
ajst-6290	224	15	558558	558558	NUM
ajst-6290	224	16	.	.	PUNCT
ajst-6290	225	1	[	[	X
ajst-6290	225	2	8	8	NUM
ajst-6290	225	3	]	]	X
ajst-6290	225	4	blair	blair	PROPN
ajst-6290	225	5	,	,	PUNCT
ajst-6290	225	6	d.	d.	PROPN
ajst-6290	225	7	"	"	PUNCT
ajst-6290	225	8	synthetic	synthetic	ADJ
ajst-6290	225	9	biology	biology	NOUN
ajst-6290	225	10	,	,	PUNCT
ajst-6290	225	11	then	then	ADV
ajst-6290	225	12	and	and	CCONJ
ajst-6290	225	13	now	now	ADV
ajst-6290	225	14	.	.	PUNCT
ajst-6290	225	15	"	"	PUNCT
ajst-6290	225	16	journal	journal	NOUN
ajst-6290	225	17	of	of	ADP
ajst-6290	225	18	the	the	DET
ajst-6290	225	19	history	history	NOUN
ajst-6290	225	20	of	of	ADP
ajst-6290	225	21	biology	biology	NOUN
ajst-6290	225	22	,	,	PUNCT
ajst-6290	225	23	vol	vol	NOUN
ajst-6290	225	24	.	.	PROPN
ajst-6290	225	25	48	48	NUM
ajst-6290	225	26	,	,	PUNCT
ajst-6290	225	27	no	no	INTJ
ajst-6290	225	28	.	.	NOUN
ajst-6290	225	29	2	2	NUM
ajst-6290	225	30	,	,	PUNCT
ajst-6290	225	31	2015	2015	NUM
ajst-6290	225	32	,	,	PUNCT
ajst-6290	225	33	pp	pp	ADJ
ajst-6290	225	34	.	.	PUNCT
ajst-6290	226	1	153	153	NUM
ajst-6290	226	2	-	-	SYM
ajst-6290	226	3	176	176	NUM
ajst-6290	226	4	.	.	PUNCT
ajst-6290	227	1	[	[	X
ajst-6290	227	2	9	9	NUM
ajst-6290	227	3	]	]	X
ajst-6290	227	4	yan	yan	PROPN
ajst-6290	227	5	,	,	PUNCT
ajst-6290	227	6	y.	y.	PROPN
ajst-6290	227	7	,	,	PUNCT
ajst-6290	227	8	liao	liao	PROPN
ajst-6290	227	9	,	,	PUNCT
ajst-6290	227	10	j.c	j.c	PROPN
ajst-6290	227	11	.	.	PROPN
ajst-6290	227	12	,	,	PUNCT
ajst-6290	227	13	and	and	CCONJ
ajst-6290	227	14	engineering	engineering	NOUN
ajst-6290	227	15	metabolic	metabolic	NOUN
ajst-6290	227	16	systems	system	NOUN
ajst-6290	227	17	for	for	ADP
ajst-6290	227	18	production	production	NOUN
ajst-6290	227	19	of	of	ADP
ajst-6290	227	20	advanced	advanced	ADJ
ajst-6290	227	21	biofuels	biofuel	NOUN
ajst-6290	227	22	.	.	PUNCT
ajst-6290	228	1	trends	trend	NOUN
ajst-6290	228	2	biotechnol	biotechnol	VERB
ajst-6290	228	3	.	.	PUNCT
ajst-6290	229	1	2016	2016	NUM
ajst-6290	229	2	,	,	PUNCT
ajst-6290	229	3	34(7	34(7	NUM
ajst-6290	229	4	):	):	PUNCT
ajst-6290	229	5	492	492	NUM
ajst-6290	229	6	-	-	SYM
ajst-6290	229	7	501	501	NUM
ajst-6290	229	8	.	.	PUNCT
ajst-6290	230	1	[	[	X
ajst-6290	230	2	10	10	NUM
ajst-6290	230	3	]	]	X
ajst-6290	230	4	liang	liang	PROPN
ajst-6290	230	5	,	,	PUNCT
ajst-6290	230	6	x.	x.	PROPN
ajst-6290	230	7	,	,	PUNCT
ajst-6290	230	8	liu	liu	PROPN
ajst-6290	230	9	,	,	PUNCT
ajst-6290	230	10	r.	r.	PROPN
ajst-6290	230	11	,	,	PUNCT
ajst-6290	230	12	and	and	CCONJ
ajst-6290	230	13	chen	chen	PROPN
ajst-6290	230	14	,	,	PUNCT
ajst-6290	230	15	j.	j.	PROPN
ajst-6290	230	16	synthetic	synthetic	ADJ
ajst-6290	230	17	biology	biology	NOUN
ajst-6290	230	18	and	and	CCONJ
ajst-6290	230	19	metabolic	metabolic	NOUN
ajst-6290	230	20	engineering	engineering	NOUN
ajst-6290	230	21	of	of	ADP
ajst-6290	230	22	corynebacterium	corynebacterium	NOUN
ajst-6290	230	23	glutamicum	glutamicum	PROPN
ajst-6290	230	24	for	for	ADP
ajst-6290	230	25	bio	bio	NOUN
ajst-6290	230	26	-	-	PUNCT
ajst-6290	230	27	based	base	VERB
ajst-6290	230	28	production	production	NOUN
ajst-6290	230	29	of	of	ADP
ajst-6290	230	30	chemicals	chemical	NOUN
ajst-6290	230	31	.	.	PUNCT
ajst-6290	231	1	j.	j.	PROPN
ajst-6290	231	2	ind	ind	PROPN
ajst-6290	231	3	.	.	PUNCT
ajst-6290	232	1	microbiol	microbiol	PROPN
ajst-6290	232	2	.	.	PUNCT
ajst-6290	233	1	biotechnol	biotechnol	PROPN
ajst-6290	233	2	.	.	PUNCT
ajst-6290	234	1	2020	2020	NUM
ajst-6290	234	2	,	,	PUNCT
ajst-6290	234	3	47(6	47(6	NUM
ajst-6290	234	4	):	):	PUNCT
ajst-6290	234	5	365	365	NUM
ajst-6290	234	6	-	-	SYM
ajst-6290	234	7	379	379	NUM
ajst-6290	234	8	.	.	PUNCT
ajst-6290	235	1	[	[	X
ajst-6290	235	2	11	11	NUM
ajst-6290	235	3	]	]	X
ajst-6290	235	4	singh	singh	PROPN
ajst-6290	235	5	,	,	PUNCT
ajst-6290	235	6	r.	r.	PROPN
ajst-6290	235	7	,	,	PUNCT
ajst-6290	235	8	kumar	kumar	PROPN
ajst-6290	235	9	,	,	PUNCT
ajst-6290	235	10	v.	v.	PROPN
ajst-6290	235	11	,	,	PUNCT
ajst-6290	235	12	singh	singh	PROPN
ajst-6290	235	13	,	,	PUNCT
ajst-6290	235	14	r.p	r.p	PROPN
ajst-6290	235	15	.	.	PROPN
ajst-6290	235	16	,	,	PUNCT
ajst-6290	235	17	and	and	CCONJ
ajst-6290	235	18	gupta	gupta	PROPN
ajst-6290	235	19	,	,	PUNCT
ajst-6290	235	20	n.	n.	NOUN
ajst-6290	235	21	synthetic	synthetic	ADJ
ajst-6290	235	22	biology	biology	NOUN
ajst-6290	235	23	in	in	ADP
ajst-6290	235	24	the	the	DET
ajst-6290	235	25	development	development	NOUN
ajst-6290	235	26	of	of	ADP
ajst-6290	235	27	microbial	microbial	ADJ
ajst-6290	235	28	biocatalysts	biocatalyst	NOUN
ajst-6290	235	29	for	for	ADP
ajst-6290	235	30	the	the	DET
ajst-6290	235	31	production	production	NOUN
ajst-6290	235	32	of	of	ADP
ajst-6290	235	33	biofuels	biofuel	NOUN
ajst-6290	235	34	and	and	CCONJ
ajst-6290	235	35	value	value	NOUN
ajst-6290	235	36	-	-	PUNCT
ajst-6290	235	37	added	add	VERB
ajst-6290	235	38	chemicals	chemical	NOUN
ajst-6290	235	39	.	.	PUNCT
ajst-6290	236	1	biotechnol	biotechnol	PROPN
ajst-6290	236	2	.	.	PUNCT
ajst-6290	237	1	lett	lett	PROPN
ajst-6290	237	2	.	.	PROPN
ajst-6290	237	3	2021	2021	NUM
ajst-6290	237	4	,	,	PUNCT
ajst-6290	237	5	43(1	43(1	NUM
ajst-6290	237	6	):	):	PUNCT
ajst-6290	237	7	43	43	NUM
ajst-6290	237	8	-	-	SYM
ajst-6290	237	9	62	62	NUM
ajst-6290	237	10	.	.	PUNCT
ajst-6290	238	1	[	[	X
ajst-6290	238	2	12	12	NUM
ajst-6290	238	3	]	]	X
ajst-6290	238	4	lee	lee	PROPN
ajst-6290	238	5	,	,	PUNCT
ajst-6290	238	6	s.y	s.y	PROPN
ajst-6290	238	7	.	.	PROPN
ajst-6290	238	8	,	,	PUNCT
ajst-6290	238	9	kim	kim	PROPN
ajst-6290	238	10	,	,	PUNCT
ajst-6290	238	11	h.u	h.u	PROPN
ajst-6290	238	12	.	.	PROPN
ajst-6290	238	13	,	,	PUNCT
ajst-6290	238	14	and	and	CCONJ
ajst-6290	238	15	chae	chae	PROPN
ajst-6290	238	16	,	,	PUNCT
ajst-6290	238	17	t.u	t.u	PROPN
ajst-6290	238	18	.	.	PROPN
ajst-6290	238	19	cho	cho	PROPN
ajst-6290	238	20	j.s	j.s	PROPN
ajst-6290	238	21	.	.	PROPN
ajst-6290	238	22	metabolic	metabolic	PROPN
ajst-6290	238	23	engineering	engineering	NOUN
ajst-6290	238	24	of	of	ADP
ajst-6290	238	25	microorganisms	microorganism	NOUN
ajst-6290	238	26	:	:	PUNCT
ajst-6290	238	27	general	general	ADJ
ajst-6290	238	28	strategies	strategy	NOUN
ajst-6290	238	29	and	and	CCONJ
ajst-6290	238	30	drug	drug	NOUN
ajst-6290	238	31	production	production	NOUN
ajst-6290	238	32	.	.	PUNCT
ajst-6290	239	1	drug	drug	NOUN
ajst-6290	239	2	discov	discov	NOUN
ajst-6290	239	3	.	.	PUNCT
ajst-6290	240	1	today	today	NOUN
ajst-6290	240	2	2009	2009	NUM
ajst-6290	240	3	,	,	PUNCT
ajst-6290	240	4	14(15	14(15	PROPN
ajst-6290	240	5	-	-	SYM
ajst-6290	240	6	16	16	NUM
ajst-6290	240	7	):	):	PUNCT
ajst-6290	240	8	78	78	NUM
ajst-6290	240	9	-	-	SYM
ajst-6290	240	10	88	88	NUM
ajst-6290	240	11	.	.	PUNCT
ajst-6290	241	1	[	[	X
ajst-6290	241	2	13	13	NUM
ajst-6290	241	3	]	]	X
ajst-6290	241	4	xiao	xiao	PROPN
ajst-6290	241	5	,	,	PUNCT
ajst-6290	241	6	y.	y.	PROPN
ajst-6290	241	7	,	,	PUNCT
ajst-6290	241	8	bowen	bowen	PROPN
ajst-6290	241	9	,	,	PUNCT
ajst-6290	241	10	c.h	c.h	PROPN
ajst-6290	241	11	.	.	PROPN
ajst-6290	241	12	,	,	PUNCT
ajst-6290	241	13	and	and	CCONJ
ajst-6290	241	14	liu	liu	PROPN
ajst-6290	241	15	,	,	PUNCT
ajst-6290	241	16	d.	d.	PROPN
ajst-6290	241	17	exploiting	exploit	VERB
ajst-6290	241	18	nongenetic	nongenetic	ADJ
ajst-6290	241	19	cellto	cellto	NOUN
ajst-6290	241	20	-	-	PUNCT
ajst-6290	241	21	cell	cell	NOUN
ajst-6290	241	22	variation	variation	NOUN
ajst-6290	241	23	for	for	ADP
ajst-6290	241	24	enhanced	enhanced	ADJ
ajst-6290	241	25	biosynthesis	biosynthesis	NOUN
ajst-6290	241	26	.	.	PUNCT
ajst-6290	242	1	nat	nat	NOUN
ajst-6290	242	2	.	.	PUNCT
ajst-6290	243	1	chem	chem	PROPN
ajst-6290	243	2	.	.	PUNCT
ajst-6290	244	1	biol	biol	PROPN
ajst-6290	244	2	.	.	PUNCT
ajst-6290	245	1	2016	2016	NUM
ajst-6290	245	2	,	,	PUNCT
ajst-6290	245	3	12(5	12(5	NUM
ajst-6290	245	4	):	):	PUNCT
ajst-6290	245	5	339	339	NUM
ajst-6290	245	6	-	-	SYM
ajst-6290	245	7	344	344	NUM
ajst-6290	245	8	.	.	PUNCT
ajst-6290	246	1	[	[	X
ajst-6290	246	2	14	14	NUM
ajst-6290	246	3	]	]	SYM
ajst-6290	246	4	kocharin	kocharin	NOUN
ajst-6290	246	5	,	,	PUNCT
ajst-6290	246	6	k.	k.	PROPN
ajst-6290	246	7	,	,	PUNCT
ajst-6290	246	8	chen	chen	PROPN
ajst-6290	246	9	,	,	PUNCT
ajst-6290	246	10	y.	y.	PROPN
ajst-6290	246	11	,	,	PUNCT
ajst-6290	246	12	and	and	CCONJ
ajst-6290	246	13	siewers	siewer	NOUN
ajst-6290	246	14	,	,	PUNCT
ajst-6290	246	15	v.	v.	ADP
ajst-6290	246	16	engineering	engineering	NOUN
ajst-6290	246	17	of	of	ADP
ajst-6290	246	18	saccharomyces	saccharomyce	NOUN
ajst-6290	246	19	cerevisiae	cerevisiae	NOUN
ajst-6290	246	20	for	for	ADP
ajst-6290	246	21	the	the	DET
ajst-6290	246	22	production	production	NOUN
ajst-6290	246	23	of	of	ADP
ajst-6290	246	24	isobutanol	isobutanol	ADJ
ajst-6290	246	25	and	and	CCONJ
ajst-6290	246	26	3	3	NUM
ajst-6290	246	27	-	-	PUNCT
ajst-6290	246	28	methyl-1	methyl-1	NOUN
ajst-6290	246	29	-	-	PUNCT
ajst-6290	246	30	butanol	butanol	NOUN
ajst-6290	246	31	.	.	PUNCT
ajst-6290	246	32	appl	appl	PROPN
ajst-6290	246	33	.	.	PUNCT
ajst-6290	247	1	microbiol	microbiol	PROPN
ajst-6290	247	2	.	.	PUNCT
ajst-6290	248	1	biotechnol	biotechnol	PROPN
ajst-6290	248	2	.	.	PUNCT
ajst-6290	249	1	2013	2013	NUM
ajst-6290	249	2	,	,	PUNCT
ajst-6290	249	3	97(19	97(19	NUM
ajst-6290	249	4	):	):	PUNCT
ajst-6290	249	5	7121	7121	NUM
ajst-6290	249	6	-	-	SYM
ajst-6290	249	7	7130	7130	NUM
ajst-6290	249	8	.	.	PUNCT
ajst-6290	250	1	[	[	X
ajst-6290	250	2	15	15	NUM
ajst-6290	250	3	]	]	X
ajst-6290	250	4	liu	liu	PROPN
ajst-6290	250	5	,	,	PUNCT
ajst-6290	250	6	j.j	j.j	PROPN
ajst-6290	250	7	.	.	PROPN
ajst-6290	250	8	,	,	PUNCT
ajst-6290	250	9	zhang	zhang	PROPN
ajst-6290	250	10	,	,	PUNCT
ajst-6290	250	11	w.	w.	PROPN
ajst-6290	250	12	,	,	PUNCT
ajst-6290	250	13	and	and	CCONJ
ajst-6290	250	14	du	du	PROPN
ajst-6290	250	15	,	,	PUNCT
ajst-6290	250	16	g.c	g.c	PROPN
ajst-6290	250	17	.	.	PROPN
ajst-6290	250	18	metabolic	metabolic	PROPN
ajst-6290	250	19	engineering	engineering	NOUN
ajst-6290	250	20	of	of	ADP
ajst-6290	250	21	saccharomyces	saccharomyce	NOUN
ajst-6290	250	22	cerevisiae	cerevisiae	NOUN
ajst-6290	250	23	for	for	ADP
ajst-6290	250	24	efficient	efficient	ADJ
ajst-6290	250	25	production	production	NOUN
ajst-6290	250	26	of	of	ADP
ajst-6290	250	27	1hexadecanol	1hexadecanol	NUM
ajst-6290	250	28	.	.	PUNCT
ajst-6290	250	29	metab	metab	PROPN
ajst-6290	250	30	.	.	PUNCT
ajst-6290	251	1	eng	eng	PROPN
ajst-6290	251	2	.	.	PROPN
ajst-6290	251	3	2016	2016	NUM
ajst-6290	251	4	,	,	PUNCT
ajst-6290	251	5	36	36	NUM
ajst-6290	251	6	:	:	SYM
ajst-6290	251	7	33	33	NUM
ajst-6290	251	8	-	-	SYM
ajst-6290	251	9	41	41	NUM
ajst-6290	251	10	.	.	PUNCT
ajst-6290	252	1	[	[	X
ajst-6290	252	2	16	16	NUM
ajst-6290	252	3	]	]	X
ajst-6290	252	4	wang	wang	PROPN
ajst-6290	252	5	,	,	PUNCT
ajst-6290	252	6	y.	y.	PROPN
ajst-6290	252	7	,	,	PUNCT
ajst-6290	252	8	chen	chen	PROPN
ajst-6290	252	9	,	,	PUNCT
ajst-6290	252	10	j.	j.	PROPN
ajst-6290	252	11	,	,	PUNCT
ajst-6290	252	12	and	and	CCONJ
ajst-6290	252	13	shen	shen	PROPN
ajst-6290	252	14	,	,	PUNCT
ajst-6290	252	15	y.	y.	PROPN
ajst-6290	252	16	engineering	engineering	NOUN
ajst-6290	252	17	saccharomyces	saccharomyce	NOUN
ajst-6290	252	18	cerevisiae	cerevisiae	NOUN
ajst-6290	252	19	for	for	ADP
ajst-6290	252	20	high	high	ADJ
ajst-6290	252	21	-	-	PUNCT
ajst-6290	252	22	level	level	NOUN
ajst-6290	252	23	synthesis	synthesis	NOUN
ajst-6290	252	24	of	of	ADP
ajst-6290	252	25	fatty	fatty	ADJ
ajst-6290	252	26	acids	acid	NOUN
ajst-6290	252	27	and	and	CCONJ
ajst-6290	252	28	derived	derived	ADJ
ajst-6290	252	29	products	product	NOUN
ajst-6290	252	30	.	.	PUNCT
ajst-6290	253	1	metab	metab	PROPN
ajst-6290	253	2	.	.	PUNCT
ajst-6290	254	1	eng	eng	PROPN
ajst-6290	254	2	.	.	PROPN
ajst-6290	254	3	2016	2016	NUM
ajst-6290	254	4	,	,	PUNCT
ajst-6290	254	5	38	38	NUM
ajst-6290	254	6	:	:	SYM
ajst-6290	254	7	85	85	NUM
ajst-6290	254	8	-	-	SYM
ajst-6290	254	9	93	93	NUM
ajst-6290	254	10	.	.	PUNCT
ajst-6290	255	1	[	[	X
ajst-6290	255	2	17	17	NUM
ajst-6290	255	3	]	]	X
ajst-6290	255	4	zhang	zhang	PROPN
ajst-6290	255	5	,	,	PUNCT
ajst-6290	255	6	y.	y.	PROPN
ajst-6290	255	7	,	,	PUNCT
ajst-6290	255	8	werling	werling	NOUN
ajst-6290	255	9	,	,	PUNCT
ajst-6290	255	10	u.	u.	PROPN
ajst-6290	255	11	,	,	PUNCT
ajst-6290	255	12	&	&	CCONJ
ajst-6290	255	13	edelmann	edelmann	PROPN
ajst-6290	255	14	,	,	PUNCT
ajst-6290	255	15	w.	w.	NOUN
ajst-6290	255	16	(	(	PUNCT
ajst-6290	255	17	2015	2015	NUM
ajst-6290	255	18	)	)	PUNCT
ajst-6290	255	19	.	.	PUNCT
ajst-6290	256	1	slice	slice	NOUN
ajst-6290	256	2	:	:	PUNCT
ajst-6290	256	3	a	a	DET
ajst-6290	256	4	novel	novel	ADJ
ajst-6290	256	5	bacterial	bacterial	ADJ
ajst-6290	256	6	cell	cell	NOUN
ajst-6290	256	7	extract	extract	NOUN
ajst-6290	256	8	-	-	PUNCT
ajst-6290	256	9	based	base	VERB
ajst-6290	256	10	dna	dna	NOUN
ajst-6290	256	11	cloning	cloning	NOUN
ajst-6290	256	12	method	method	NOUN
ajst-6290	256	13	.	.	PUNCT
ajst-6290	257	1	nucleic	nucleic	ADJ
ajst-6290	257	2	acids	acid	NOUN
ajst-6290	257	3	research	research	NOUN
ajst-6290	257	4	,	,	PUNCT
ajst-6290	257	5	44(8	44(8	NOUN
ajst-6290	257	6	)	)	PUNCT
ajst-6290	257	7	,	,	PUNCT
ajst-6290	257	8	e71	e71	NOUN
ajst-6290	257	9	-	-	PUNCT
ajst-6290	257	10	e71	e71	NOUN
ajst-6290	257	11	.	.	PUNCT
ajst-6290	258	1	[	[	X
ajst-6290	258	2	18	18	NUM
ajst-6290	258	3	]	]	X
ajst-6290	258	4	gibson	gibson	PROPN
ajst-6290	258	5	,	,	PUNCT
ajst-6290	258	6	d.	d.	PROPN
ajst-6290	258	7	g.	g.	PROPN
ajst-6290	258	8	,	,	PUNCT
ajst-6290	258	9	young	young	PROPN
ajst-6290	258	10	,	,	PUNCT
ajst-6290	258	11	l.	l.	PROPN
ajst-6290	258	12	,	,	PUNCT
ajst-6290	258	13	chuang	chuang	PROPN
ajst-6290	258	14	,	,	PUNCT
ajst-6290	258	15	r.	r.	PROPN
ajst-6290	258	16	y.	y.	PROPN
ajst-6290	258	17	,	,	PUNCT
ajst-6290	258	18	venter	venter	PROPN
ajst-6290	258	19	,	,	PUNCT
ajst-6290	258	20	j.	j.	PROPN
ajst-6290	258	21	c.	c.	PROPN
ajst-6290	258	22	,	,	PUNCT
ajst-6290	258	23	hutchison	hutchison	PROPN
ajst-6290	258	24	iii	iii	PROPN
ajst-6290	258	25	,	,	PUNCT
ajst-6290	258	26	c.	c.	PROPN
ajst-6290	258	27	a.	a.	PROPN
ajst-6290	258	28	,	,	PUNCT
ajst-6290	258	29	&	&	CCONJ
ajst-6290	258	30	smith	smith	PROPN
ajst-6290	258	31	,	,	PUNCT
ajst-6290	258	32	h.	h.	PROPN
ajst-6290	258	33	o.	o.	PROPN
ajst-6290	258	34	(	(	PUNCT
ajst-6290	258	35	2009	2009	NUM
ajst-6290	258	36	)	)	PUNCT
ajst-6290	258	37	.	.	PUNCT
ajst-6290	259	1	enzymatic	enzymatic	ADJ
ajst-6290	259	2	assembly	assembly	NOUN
ajst-6290	259	3	of	of	ADP
ajst-6290	259	4	dna	dna	PROPN
ajst-6290	259	5	molecules	molecule	NOUN
ajst-6290	259	6	up	up	ADP
ajst-6290	259	7	to	to	ADP
ajst-6290	259	8	several	several	ADJ
ajst-6290	259	9	hundred	hundred	NUM
ajst-6290	259	10	kilobases	kilobase	NOUN
ajst-6290	259	11	.	.	PUNCT
ajst-6290	260	1	nature	nature	NOUN
ajst-6290	260	2	methods	method	NOUN
ajst-6290	260	3	,	,	PUNCT
ajst-6290	260	4	6(5	6(5	NUM
ajst-6290	260	5	)	)	PUNCT
ajst-6290	260	6	,	,	PUNCT
ajst-6290	260	7	343	343	NUM
ajst-6290	260	8	-	-	SYM
ajst-6290	260	9	345	345	NUM
ajst-6290	260	10	.	.	PUNCT
ajst-6290	261	1	[	[	X
ajst-6290	261	2	19	19	NUM
ajst-6290	261	3	]	]	X
ajst-6290	261	4	huang	huang	PROPN
ajst-6290	261	5	,	,	PUNCT
ajst-6290	261	6	t.	t.	PROPN
ajst-6290	261	7	,	,	PUNCT
ajst-6290	261	8	li	li	PROPN
ajst-6290	261	9	,	,	PUNCT
ajst-6290	261	10	g.	g.	PROPN
ajst-6290	261	11	,	,	PUNCT
ajst-6290	261	12	tian	tian	PROPN
ajst-6290	261	13	,	,	PUNCT
ajst-6290	261	14	y.	y.	PROPN
ajst-6290	261	15	,	,	PUNCT
ajst-6290	261	16	chen	chen	PROPN
ajst-6290	261	17	,	,	PUNCT
ajst-6290	261	18	w.	w.	PROPN
ajst-6290	261	19	,	,	PUNCT
ajst-6290	261	20	and	and	CCONJ
ajst-6290	261	21	li	li	PROPN
ajst-6290	261	22	,	,	PUNCT
ajst-6290	261	23	y.	y.	PROPN
ajst-6290	261	24	(	(	PUNCT
ajst-6290	261	25	2018	2018	NUM
ajst-6290	261	26	)	)	PUNCT
ajst-6290	261	27	.	.	PUNCT
ajst-6290	261	28	advances	advance	NOUN
ajst-6290	261	29	in	in	ADP
ajst-6290	261	30	microbial	microbial	ADJ
ajst-6290	261	31	synthesis	synthesis	NOUN
ajst-6290	261	32	of	of	ADP
ajst-6290	261	33	tyrosine	tyrosine	NOUN
ajst-6290	261	34	and	and	CCONJ
ajst-6290	261	35	its	its	PRON
ajst-6290	261	36	potential	potential	ADJ
ajst-6290	261	37	applications	application	NOUN
ajst-6290	261	38	.	.	PUNCT
ajst-6290	262	1	crit	crit	PROPN
ajst-6290	262	2	.	.	PUNCT
ajst-6290	263	1	rev	rev	PROPN
ajst-6290	263	2	.	.	PROPN
ajst-6290	263	3	biotechnol	biotechnol	PROPN
ajst-6290	263	4	.	.	PUNCT
ajst-6290	264	1	38	38	NUM
ajst-6290	264	2	,	,	PUNCT
ajst-6290	264	3	1057	1057	NUM
ajst-6290	264	4	-	-	SYM
ajst-6290	264	5	1072	1072	NUM
ajst-6290	264	6	.	.	PUNCT
ajst-6290	265	1	[	[	X
ajst-6290	265	2	20	20	NUM
ajst-6290	265	3	]	]	X
ajst-6290	265	4	zhou	zhou	PROPN
ajst-6290	265	5	,	,	PUNCT
ajst-6290	265	6	l.	l.	PROPN
ajst-6290	265	7	,	,	PUNCT
ajst-6290	265	8	zeng	zeng	PROPN
ajst-6290	265	9	,	,	PUNCT
ajst-6290	265	10	j.	j.	PROPN
ajst-6290	265	11	,	,	PUNCT
ajst-6290	265	12	wang	wang	PROPN
ajst-6290	265	13	,	,	PUNCT
ajst-6290	265	14	m.	m.	NOUN
ajst-6290	265	15	,	,	PUNCT
ajst-6290	265	16	and	and	CCONJ
ajst-6290	265	17	wei	wei	PROPN
ajst-6290	265	18	,	,	PUNCT
ajst-6290	265	19	d.	d.	PROPN
ajst-6290	265	20	(	(	PUNCT
ajst-6290	265	21	2015	2015	NUM
ajst-6290	265	22	)	)	PUNCT
ajst-6290	265	23	.	.	PUNCT
ajst-6290	266	1	heterologous	heterologous	ADJ
ajst-6290	266	2	expression	expression	NOUN
ajst-6290	266	3	of	of	ADP
ajst-6290	266	4	a	a	DET
ajst-6290	266	5	deacetylaszalactone	deacetylaszalactone	NOUN
ajst-6290	266	6	-	-	PUNCT
ajst-6290	266	7	producing	produce	VERB
ajst-6290	266	8	gene	gene	NOUN
ajst-6290	266	9	from	from	ADP
ajst-6290	266	10	aspergillus	aspergillus	PROPN
ajst-6290	266	11	terreus	terreus	NOUN
ajst-6290	266	12	in	in	ADP
ajst-6290	266	13	aspergillus	aspergillus	NOUN
ajst-6290	266	14	nidulans	nidulan	NOUN
ajst-6290	266	15	.	.	PUNCT
ajst-6290	267	1	biotechnol	biotechnol	PROPN
ajst-6290	267	2	.	.	PUNCT
ajst-6290	268	1	lett	lett	PROPN
ajst-6290	268	2	.	.	PUNCT
ajst-6290	269	1	37	37	NUM
ajst-6290	269	2	,	,	PUNCT
ajst-6290	269	3	977	977	NUM
ajst-6290	269	4	-	-	SYM
ajst-6290	269	5	983	983	NUM
ajst-6290	269	6	.	.	PUNCT
ajst-6290	270	1	[	[	X
ajst-6290	270	2	21	21	NUM
ajst-6290	270	3	]	]	X
ajst-6290	270	4	cong	cong	PROPN
ajst-6290	270	5	,	,	PUNCT
ajst-6290	270	6	l.	l.	PROPN
ajst-6290	270	7	,	,	PUNCT
ajst-6290	270	8	ran	run	VERB
ajst-6290	270	9	,	,	PUNCT
ajst-6290	270	10	f.	f.	PROPN
ajst-6290	270	11	a.	a.	PROPN
ajst-6290	270	12	,	,	PUNCT
ajst-6290	270	13	cox	cox	PROPN
ajst-6290	270	14	,	,	PUNCT
ajst-6290	270	15	d.	d.	PROPN
ajst-6290	270	16	,	,	PUNCT
ajst-6290	270	17	lin	lin	PROPN
ajst-6290	270	18	,	,	PUNCT
ajst-6290	270	19	s.	s.	PROPN
ajst-6290	270	20	,	,	PUNCT
ajst-6290	270	21	barretto	barretto	PROPN
ajst-6290	270	22	,	,	PUNCT
ajst-6290	270	23	r.	r.	PROPN
ajst-6290	270	24	,	,	PUNCT
ajst-6290	270	25	habib	habib	PROPN
ajst-6290	270	26	,	,	PUNCT
ajst-6290	270	27	n.	n.	NOUN
ajst-6290	270	28	,	,	PUNCT
ajst-6290	270	29	...	...	PUNCT
ajst-6290	270	30	&	&	CCONJ
ajst-6290	270	31	zhang	zhang	PROPN
ajst-6290	270	32	,	,	PUNCT
ajst-6290	270	33	f.	f.	PROPN
ajst-6290	270	34	(	(	PUNCT
ajst-6290	270	35	2013	2013	NUM
ajst-6290	270	36	)	)	PUNCT
ajst-6290	270	37	.	.	PUNCT
ajst-6290	271	1	multiplex	multiplex	PROPN
ajst-6290	271	2	genome	genome	NOUN
ajst-6290	271	3	engineering	engineering	NOUN
ajst-6290	271	4	using	use	VERB
ajst-6290	271	5	crispr	crispr	ADJ
ajst-6290	271	6	/	/	SYM
ajst-6290	271	7	cas	cas	NOUN
ajst-6290	271	8	systems	system	NOUN
ajst-6290	271	9	.	.	PUNCT
ajst-6290	272	1	science	science	NOUN
ajst-6290	272	2	,	,	PUNCT
ajst-6290	272	3	339(6121	339(6121	NUM
ajst-6290	272	4	)	)	PUNCT
ajst-6290	272	5	,	,	PUNCT
ajst-6290	272	6	819	819	NUM
ajst-6290	272	7	-	-	SYM
ajst-6290	272	8	823	823	NUM
ajst-6290	272	9	.	.	PUNCT
ajst-6290	273	1	[	[	X
ajst-6290	273	2	22	22	NUM
ajst-6290	273	3	]	]	X
ajst-6290	273	4	keasling	keasling	NOUN
ajst-6290	273	5	,	,	PUNCT
ajst-6290	273	6	j.	j.	PROPN
ajst-6290	273	7	d.	d.	PROPN
ajst-6290	273	8	,	,	PUNCT
ajst-6290	273	9	paddon	paddon	PROPN
ajst-6290	273	10	,	,	PUNCT
ajst-6290	273	11	c.	c.	PROPN
ajst-6290	273	12	j.	j.	PROPN
ajst-6290	273	13	,	,	PUNCT
ajst-6290	273	14	&	&	CCONJ
ajst-6290	273	15	keasling	keasling	PROPN
ajst-6290	273	16	,	,	PUNCT
ajst-6290	273	17	j.	j.	PROPN
ajst-6290	273	18	d.	d.	PROPN
ajst-6290	273	19	(	(	PUNCT
ajst-6290	273	20	2006	2006	NUM
ajst-6290	273	21	)	)	PUNCT
ajst-6290	273	22	.	.	PUNCT
ajst-6290	274	1	production	production	NOUN
ajst-6290	274	2	of	of	ADP
ajst-6290	274	3	the	the	DET
ajst-6290	274	4	antimalarial	antimalarial	ADJ
ajst-6290	274	5	drug	drug	NOUN
ajst-6290	274	6	precursor	precursor	NOUN
ajst-6290	274	7	artemisinic	artemisinic	VERB
ajst-6290	274	8	acid	acid	NOUN
ajst-6290	274	9	in	in	ADP
ajst-6290	274	10	engineered	engineer	VERB
ajst-6290	274	11	yeast	yeast	NOUN
ajst-6290	274	12	.	.	PUNCT
ajst-6290	275	1	science	science	NOUN
ajst-6290	275	2	,	,	PUNCT
ajst-6290	275	3	307(5714	307(5714	NUM
ajst-6290	275	4	)	)	PUNCT
ajst-6290	275	5	,	,	PUNCT
ajst-6290	275	6	1464	1464	NUM
ajst-6290	275	7	-	-	SYM
ajst-6290	275	8	1468	1468	NUM
ajst-6290	275	9	.	.	PUNCT
ajst-6290	276	1	doi:10.1126	doi:10.1126	PROPN
ajst-6290	276	2	/	/	SYM
ajst-6290	276	3	science.1105404	science.1105404	PROPN
ajst-6290	276	4	[	[	X
ajst-6290	276	5	23	23	NUM
ajst-6290	276	6	]	]	X
ajst-6290	276	7	jeong	jeong	PROPN
ajst-6290	276	8	,	,	PUNCT
ajst-6290	276	9	d.-e	d.-e	PROPN
ajst-6290	276	10	.	.	PUNCT
ajst-6290	276	11	,	,	PUNCT
ajst-6290	276	12	park	park	PROPN
ajst-6290	276	13	,	,	PUNCT
ajst-6290	276	14	s.	s.	PROPN
ajst-6290	276	15	j.	j.	PROPN
ajst-6290	276	16	,	,	PUNCT
ajst-6290	276	17	pan	pan	PROPN
ajst-6290	276	18	,	,	PUNCT
ajst-6290	276	19	j.	j.	PROPN
ajst-6290	276	20	g.	g.	PROPN
ajst-6290	276	21	,	,	PUNCT
ajst-6290	276	22	&	&	CCONJ
ajst-6290	276	23	kim	kim	PROPN
ajst-6290	276	24	,	,	PUNCT
ajst-6290	276	25	y.	y.	PROPN
ajst-6290	276	26	h.	h.	PROPN
ajst-6290	276	27	(	(	PUNCT
ajst-6290	276	28	2012	2012	NUM
ajst-6290	276	29	)	)	PUNCT
ajst-6290	276	30	.	.	PUNCT
ajst-6290	277	1	microbial	microbial	ADJ
ajst-6290	277	2	production	production	NOUN
ajst-6290	277	3	of	of	ADP
ajst-6290	277	4	1,5	1,5	NUM
ajst-6290	277	5	-	-	PUNCT
ajst-6290	277	6	pentanediol	pentanediol	NOUN
ajst-6290	277	7	via	via	ADP
ajst-6290	277	8	reduction	reduction	NOUN
ajst-6290	277	9	of	of	ADP
ajst-6290	277	10	2ketoglutarate	2ketoglutarate	NUM
ajst-6290	277	11	coupled	couple	VERB
ajst-6290	277	12	with	with	ADP
ajst-6290	277	13	acetoin	acetoin	ADJ
ajst-6290	277	14	reduction	reduction	NOUN
ajst-6290	277	15	.	.	PUNCT
ajst-6290	278	1	applied	apply	VERB
ajst-6290	278	2	and	and	CCONJ
ajst-6290	278	3	environmental	environmental	ADJ
ajst-6290	278	4	microbiology	microbiology	NOUN
ajst-6290	278	5	,	,	PUNCT
ajst-6290	278	6	78(15	78(15	PROPN
ajst-6290	278	7	)	)	PUNCT
ajst-6290	278	8	,	,	PUNCT
ajst-6290	278	9	5494	5494	NUM
ajst-6290	278	10	-	-	SYM
ajst-6290	278	11	5502	5502	NUM
ajst-6290	278	12	.	.	PUNCT
ajst-6290	279	1	doi:10.1128	doi:10.1128	NOUN
ajst-6290	279	2	/	/	SYM
ajst-6290	279	3	aem.01037	aem.01037	NOUN
ajst-6290	279	4	-	-	SYM
ajst-6290	279	5	12	12	NUM
ajst-6290	279	6	[	[	SYM
ajst-6290	279	7	24	24	NUM
ajst-6290	279	8	]	]	SYM
ajst-6290	279	9	keasling	keasling	NOUN
ajst-6290	279	10	,	,	PUNCT
ajst-6290	279	11	j.	j.	PROPN
ajst-6290	279	12	d.	d.	PROPN
ajst-6290	279	13	(	(	PUNCT
ajst-6290	279	14	2010	2010	NUM
ajst-6290	279	15	)	)	PUNCT
ajst-6290	279	16	.	.	PUNCT
ajst-6290	280	1	manufacturing	manufacture	VERB
ajst-6290	280	2	molecules	molecule	NOUN
ajst-6290	280	3	through	through	ADP
ajst-6290	280	4	metabolic	metabolic	NOUN
ajst-6290	280	5	engineering	engineering	NOUN
ajst-6290	280	6	.	.	PUNCT
ajst-6290	281	1	science	science	NOUN
ajst-6290	281	2	,	,	PUNCT
ajst-6290	281	3	330(6009	330(6009	NUM
ajst-6290	281	4	)	)	PUNCT
ajst-6290	281	5	,	,	PUNCT
ajst-6290	281	6	1355	1355	NUM
ajst-6290	281	7	-	-	SYM
ajst-6290	281	8	1358	1358	NUM
ajst-6290	281	9	.	.	PUNCT
ajst-6290	282	1	[	[	X
ajst-6290	282	2	25	25	NUM
ajst-6290	282	3	]	]	X
ajst-6290	282	4	leonard	leonard	PROPN
ajst-6290	282	5	,	,	PUNCT
ajst-6290	282	6	e.	e.	PROPN
ajst-6290	282	7	,	,	PUNCT
ajst-6290	282	8	lim	lim	PROPN
ajst-6290	282	9	,	,	PUNCT
ajst-6290	282	10	k.	k.	PROPN
ajst-6290	282	11	h.	h.	PROPN
ajst-6290	282	12	,	,	PUNCT
ajst-6290	282	13	&	&	CCONJ
ajst-6290	282	14	koffas	koffas	PROPN
ajst-6290	282	15	,	,	PUNCT
ajst-6290	282	16	m.	m.	NOUN
ajst-6290	282	17	a.	a.	NOUN
ajst-6290	282	18	(	(	PUNCT
ajst-6290	282	19	2007	2007	NUM
ajst-6290	282	20	)	)	PUNCT
ajst-6290	282	21	.	.	PUNCT
ajst-6290	283	1	engineering	engineer	VERB
ajst-6290	283	2	central	central	ADJ
ajst-6290	283	3	metabolic	metabolic	NOUN
ajst-6290	283	4	pathways	pathway	NOUN
ajst-6290	283	5	for	for	ADP
ajst-6290	283	6	high	high	ADJ
ajst-6290	283	7	-	-	PUNCT
ajst-6290	283	8	level	level	NOUN
ajst-6290	283	9	flavonoid	flavonoid	NOUN
ajst-6290	283	10	production	production	NOUN
ajst-6290	283	11	in	in	ADP
ajst-6290	283	12	escherichia	escherichia	NOUN
ajst-6290	283	13	coli	coli	NOUN
ajst-6290	283	14	.	.	PUNCT
ajst-6290	284	1	applied	apply	VERB
ajst-6290	284	2	and	and	CCONJ
ajst-6290	284	3	environmental	environmental	ADJ
ajst-6290	284	4	microbiology	microbiology	NOUN
ajst-6290	284	5	,	,	PUNCT
ajst-6290	284	6	73(13	73(13	PROPN
ajst-6290	284	7	)	)	PUNCT
ajst-6290	284	8	,	,	PUNCT
ajst-6290	284	9	3877	3877	NUM
ajst-6290	284	10	-	-	SYM
ajst-6290	284	11	3886	3886	NUM
ajst-6290	284	12	.	.	PUNCT
ajst-6290	285	1	[	[	X
ajst-6290	285	2	26	26	NUM
ajst-6290	285	3	]	]	X
ajst-6290	285	4	brenner	brenner	NOUN
ajst-6290	285	5	,	,	PUNCT
ajst-6290	285	6	k.	k.	PROPN
ajst-6290	285	7	,	,	PUNCT
ajst-6290	285	8	karig	karig	PROPN
ajst-6290	285	9	,	,	PUNCT
ajst-6290	285	10	d.	d.	PROPN
ajst-6290	285	11	k.	k.	PROPN
ajst-6290	285	12	,	,	PUNCT
ajst-6290	285	13	weiss	weiss	PROPN
ajst-6290	285	14	,	,	PUNCT
ajst-6290	285	15	r.	r.	PROPN
ajst-6290	285	16	,	,	PUNCT
ajst-6290	285	17	&	&	CCONJ
ajst-6290	285	18	arnold	arnold	PROPN
ajst-6290	285	19	,	,	PUNCT
ajst-6290	285	20	f.	f.	PROPN
ajst-6290	285	21	h.	h.	PROPN
ajst-6290	285	22	(	(	PUNCT
ajst-6290	285	23	2007	2007	NUM
ajst-6290	285	24	)	)	PUNCT
ajst-6290	285	25	.	.	PUNCT
ajst-6290	286	1	engineered	engineer	VERB
ajst-6290	286	2	bidirectional	bidirectional	ADJ
ajst-6290	286	3	communication	communication	NOUN
ajst-6290	286	4	mediates	mediate	VERB
ajst-6290	286	5	a	a	DET
ajst-6290	286	6	consensus	consensus	NOUN
ajst-6290	286	7	in	in	ADP
ajst-6290	286	8	a	a	DET
ajst-6290	286	9	microbial	microbial	ADJ
ajst-6290	286	10	biofilm	biofilm	NOUN
ajst-6290	286	11	consortium	consortium	NOUN
ajst-6290	286	12	.	.	PUNCT
ajst-6290	287	1	proceedings	proceeding	NOUN
ajst-6290	287	2	of	of	ADP
ajst-6290	287	3	the	the	DET
ajst-6290	287	4	national	national	PROPN
ajst-6290	287	5	academy	academy	PROPN
ajst-6290	287	6	of	of	ADP
ajst-6290	287	7	sciences	sciences	PROPN
ajst-6290	287	8	,	,	PUNCT
ajst-6290	287	9	104(38	104(38	NUM
ajst-6290	287	10	)	)	PUNCT
ajst-6290	287	11	,	,	PUNCT
ajst-6290	287	12	17300	17300	NUM
ajst-6290	287	13	-	-	SYM
ajst-6290	287	14	17304	17304	NUM
ajst-6290	287	15	.	.	PUNCT
ajst-6290	288	1	101	101	NUM
ajst-6290	288	2	[	[	SYM
ajst-6290	288	3	27	27	NUM
ajst-6290	288	4	]	]	X
ajst-6290	288	5	kortmann	kortmann	PROPN
ajst-6290	288	6	,	,	PUNCT
ajst-6290	288	7	h.	h.	PROPN
ajst-6290	288	8	,	,	PUNCT
ajst-6290	288	9	scrima	scrima	PROPN
ajst-6290	288	10	,	,	PUNCT
ajst-6290	288	11	a.	a.	NOUN
ajst-6290	288	12	,	,	PUNCT
ajst-6290	288	13	&	&	CCONJ
ajst-6290	288	14	plum	plum	PROPN
ajst-6290	288	15	,	,	PUNCT
ajst-6290	288	16	g.	g.	PROPN
ajst-6290	288	17	(	(	PUNCT
ajst-6290	288	18	2011	2011	NUM
ajst-6290	288	19	)	)	PUNCT
ajst-6290	288	20	.	.	PUNCT
ajst-6290	289	1	synthetic	synthetic	ADJ
ajst-6290	289	2	biology	biology	NOUN
ajst-6290	289	3	approaches	approach	VERB
ajst-6290	289	4	in	in	ADP
ajst-6290	289	5	cancer	cancer	NOUN
ajst-6290	289	6	research	research	NOUN
ajst-6290	289	7	.	.	PUNCT
ajst-6290	290	1	journal	journal	NOUN
ajst-6290	290	2	of	of	ADP
ajst-6290	290	3	cellular	cellular	ADJ
ajst-6290	290	4	and	and	CCONJ
ajst-6290	290	5	molecular	molecular	ADJ
ajst-6290	290	6	medicine	medicine	NOUN
ajst-6290	290	7	,	,	PUNCT
ajst-6290	290	8	15(2	15(2	NUM
ajst-6290	290	9	)	)	PUNCT
ajst-6290	290	10	,	,	PUNCT
ajst-6290	290	11	241	241	NUM
ajst-6290	290	12	-	-	SYM
ajst-6290	290	13	247	247	NUM
ajst-6290	290	14	.	.	PUNCT
ajst-6290	291	1	[	[	X
ajst-6290	291	2	28	28	NUM
ajst-6290	291	3	]	]	X
ajst-6290	291	4	chao	chao	PROPN
ajst-6290	291	5	r	r	PROPN
ajst-6290	291	6	,	,	PUNCT
ajst-6290	291	7	yuan	yuan	PROPN
ajst-6290	291	8	y	y	PROPN
ajst-6290	291	9	,	,	PUNCT
ajst-6290	291	10	zhao	zhao	PROPN
ajst-6290	291	11	h.	h.	PROPN
ajst-6290	292	1	recent	recent	ADJ
ajst-6290	292	2	advances	advance	NOUN
ajst-6290	292	3	in	in	ADP
ajst-6290	292	4	dna	dna	PROPN
ajst-6290	292	5	assembly	assembly	NOUN
ajst-6290	292	6	technologies	technology	NOUN
ajst-6290	292	7	.	.	PUNCT
ajst-6290	293	1	fems	fems	PROPN
ajst-6290	293	2	yeast	yeast	NOUN
ajst-6290	293	3	research	research	NOUN
ajst-6290	293	4	.	.	PUNCT
ajst-6290	294	1	2015;15(1):1	2015;15(1):1	NUM
ajst-6290	294	2	-	-	SYM
ajst-6290	294	3	9	9	NUM
ajst-6290	294	4	.	.	PUNCT
ajst-6290	295	1	[	[	X
ajst-6290	295	2	29	29	NUM
ajst-6290	295	3	]	]	X
ajst-6290	295	4	schmidt	schmidt	PROPN
ajst-6290	295	5	m	m	PROPN
ajst-6290	295	6	,	,	PUNCT
ajst-6290	295	7	pei	pei	PROPN
ajst-6290	295	8	l	l	PROPN
ajst-6290	295	9	,	,	PUNCT
ajst-6290	295	10	synatschke	synatschke	PROPN
ajst-6290	295	11	cv	cv	PROPN
ajst-6290	295	12	,	,	PUNCT
ajst-6290	295	13	et	et	PROPN
ajst-6290	295	14	al	al	PROPN
ajst-6290	295	15	.	.	PUNCT
ajst-6290	296	1	dna	dna	PROPN
ajst-6290	296	2	-	-	PUNCT
ajst-6290	296	3	based	base	VERB
ajst-6290	296	4	architectures	architecture	NOUN
ajst-6290	296	5	for	for	ADP
ajst-6290	296	6	advanced	advanced	ADJ
ajst-6290	296	7	applications	application	NOUN
ajst-6290	296	8	.	.	PUNCT
ajst-6290	297	1	chemical	chemical	ADJ
ajst-6290	297	2	society	society	NOUN
ajst-6290	297	3	reviews	review	NOUN
ajst-6290	297	4	.	.	PUNCT
ajst-6290	298	1	2018;47(17):6480	2018;47(17):6480	NUM
ajst-6290	298	2	-	-	SYM
ajst-6290	298	3	6516	6516	NUM
ajst-6290	298	4	.	.	PUNCT
ajst-6290	299	1	[	[	X
ajst-6290	299	2	30	30	NUM
ajst-6290	299	3	]	]	X
ajst-6290	299	4	delebecque	delebecque	ADJ
ajst-6290	299	5	cj	cj	NOUN
ajst-6290	299	6	,	,	PUNCT
ajst-6290	299	7	lindner	lindner	PROPN
ajst-6290	299	8	ab	ab	PROPN
ajst-6290	299	9	,	,	PUNCT
ajst-6290	299	10	silver	silver	PROPN
ajst-6290	299	11	pa	pa	PROPN
ajst-6290	299	12	,	,	PUNCT
ajst-6290	299	13	aldaye	aldaye	PROPN
ajst-6290	299	14	fa	fa	PROPN
ajst-6290	299	15	.	.	PROPN
ajst-6290	299	16	organization	organization	NOUN
ajst-6290	299	17	of	of	ADP
ajst-6290	299	18	intracellular	intracellular	ADJ
ajst-6290	299	19	reactions	reaction	NOUN
ajst-6290	299	20	with	with	ADP
ajst-6290	299	21	rationally	rationally	ADV
ajst-6290	299	22	designed	design	VERB
ajst-6290	299	23	rna	rna	NOUN
ajst-6290	299	24	assem	assem	NOUN
ajst-6290	299	25	.	.	PUNCT