id	sid	tid	token	lemma	pos
ajst-938	1	1	academic	academic	ADJ
ajst-938	1	2	journal	journal	NOUN
ajst-938	1	3	of	of	ADP
ajst-938	1	4	science	science	NOUN
ajst-938	1	5	and	and	CCONJ
ajst-938	1	6	technology	technology	NOUN
ajst-938	1	7	issn	issn	NOUN
ajst-938	1	8	:	:	PUNCT
ajst-938	1	9	2771	2771	NUM
ajst-938	1	10	-	-	SYM
ajst-938	1	11	3032	3032	NUM
ajst-938	1	12	|	|	NOUN
ajst-938	1	13	vol	vol	NOUN
ajst-938	1	14	.	.	PROPN
ajst-938	2	1	2	2	NUM
ajst-938	2	2	,	,	PUNCT
ajst-938	2	3	no	no	INTJ
ajst-938	2	4	.	.	NOUN
ajst-938	2	5	1	1	NUM
ajst-938	2	6	,	,	PUNCT
ajst-938	2	7	2022	2022	NUM
ajst-938	2	8	136	136	NUM
ajst-938	2	9	immunomodulation	immunomodulation	NOUN
ajst-938	2	10	as	as	ADP
ajst-938	2	11	a	a	DET
ajst-938	2	12	treatment	treatment	NOUN
ajst-938	2	13	to	to	ADP
ajst-938	2	14	breast	breast	NOUN
ajst-938	2	15	cancer	cancer	NOUN
ajst-938	2	16	yichen	yichen	PROPN
ajst-938	2	17	gong	gong	PROPN
ajst-938	3	1	shanghai	shanghai	PROPN
ajst-938	3	2	jianping	jianping	PROPN
ajst-938	3	3	high	high	ADJ
ajst-938	3	4	school	school	NOUN
ajst-938	3	5	,	,	PUNCT
ajst-938	3	6	shanghai	shanghai	PROPN
ajst-938	3	7	,	,	PUNCT
ajst-938	3	8	200135	200135	NUM
ajst-938	3	9	,	,	PUNCT
ajst-938	3	10	china	china	PROPN
ajst-938	3	11	abstract	abstract	NOUN
ajst-938	3	12	:	:	PUNCT
ajst-938	3	13	in	in	ADP
ajst-938	3	14	recent	recent	ADJ
ajst-938	3	15	years	year	NOUN
ajst-938	3	16	,	,	PUNCT
ajst-938	3	17	breast	breast	NOUN
ajst-938	3	18	cancer	cancer	NOUN
ajst-938	3	19	has	have	AUX
ajst-938	3	20	been	be	AUX
ajst-938	3	21	the	the	DET
ajst-938	3	22	leading	lead	VERB
ajst-938	3	23	cause	cause	NOUN
ajst-938	3	24	of	of	ADP
ajst-938	3	25	cancer	cancer	NOUN
ajst-938	3	26	death	death	NOUN
ajst-938	3	27	among	among	ADP
ajst-938	3	28	women	woman	NOUN
ajst-938	3	29	.	.	PUNCT
ajst-938	4	1	researchers	researcher	NOUN
ajst-938	4	2	are	be	AUX
ajst-938	4	3	leading	lead	VERB
ajst-938	4	4	studies	study	NOUN
ajst-938	4	5	related	relate	VERB
ajst-938	4	6	to	to	ADP
ajst-938	4	7	the	the	DET
ajst-938	4	8	breast	breast	NOUN
ajst-938	4	9	cancer	cancer	NOUN
ajst-938	4	10	to	to	PART
ajst-938	4	11	help	help	VERB
ajst-938	4	12	with	with	ADP
ajst-938	4	13	progress	progress	NOUN
ajst-938	4	14	of	of	ADP
ajst-938	4	15	our	our	PRON
ajst-938	4	16	understanding	understanding	NOUN
ajst-938	4	17	of	of	ADP
ajst-938	4	18	cancer	cancer	NOUN
ajst-938	4	19	and	and	CCONJ
ajst-938	4	20	exploring	explore	VERB
ajst-938	4	21	more	more	ADV
ajst-938	4	22	efficient	efficient	ADJ
ajst-938	4	23	and	and	CCONJ
ajst-938	4	24	less	less	ADV
ajst-938	4	25	toxic	toxic	ADJ
ajst-938	4	26	therapies	therapy	NOUN
ajst-938	4	27	.	.	PUNCT
ajst-938	5	1	increased	increase	VERB
ajst-938	5	2	public	public	ADJ
ajst-938	5	3	awareness	awareness	NOUN
ajst-938	5	4	and	and	CCONJ
ajst-938	5	5	advances	advance	NOUN
ajst-938	5	6	in	in	ADP
ajst-938	5	7	the	the	DET
ajst-938	5	8	preclinical	preclinical	ADJ
ajst-938	5	9	proof	proof	NOUN
ajst-938	5	10	of	of	ADP
ajst-938	5	11	feasibility	feasibility	NOUN
ajst-938	5	12	and	and	CCONJ
ajst-938	5	13	clinical	clinical	ADJ
ajst-938	5	14	confirmation	confirmation	NOUN
ajst-938	5	15	of	of	ADP
ajst-938	5	16	have	have	AUX
ajst-938	5	17	led	lead	VERB
ajst-938	5	18	to	to	ADP
ajst-938	5	19	earlier	early	ADJ
ajst-938	5	20	diagnosis	diagnosis	NOUN
ajst-938	5	21	and	and	CCONJ
ajst-938	5	22	novel	novel	ADJ
ajst-938	5	23	curative	curative	ADJ
ajst-938	5	24	therapies	therapy	NOUN
ajst-938	5	25	.	.	PUNCT
ajst-938	6	1	immunomodulation	immunomodulation	NOUN
ajst-938	6	2	is	be	AUX
ajst-938	6	3	an	an	DET
ajst-938	6	4	emerging	emerge	VERB
ajst-938	6	5	treatment	treatment	NOUN
ajst-938	6	6	,	,	PUNCT
ajst-938	6	7	which	which	PRON
ajst-938	6	8	enhance	enhance	VERB
ajst-938	6	9	the	the	DET
ajst-938	6	10	immunity	immunity	NOUN
ajst-938	6	11	against	against	ADP
ajst-938	6	12	cancer	cancer	NOUN
ajst-938	6	13	cells	cell	NOUN
ajst-938	6	14	through	through	ADP
ajst-938	6	15	releasing	release	VERB
ajst-938	6	16	various	various	ADJ
ajst-938	6	17	cytokines	cytokine	NOUN
ajst-938	6	18	,	,	PUNCT
ajst-938	6	19	expanding	expand	VERB
ajst-938	6	20	to	to	ADP
ajst-938	6	21	gene	gene	NOUN
ajst-938	6	22	-	-	PUNCT
ajst-938	6	23	based	base	VERB
ajst-938	6	24	treatments	treatment	NOUN
ajst-938	6	25	.	.	PUNCT
ajst-938	7	1	therefore	therefore	ADV
ajst-938	7	2	,	,	PUNCT
ajst-938	7	3	this	this	DET
ajst-938	7	4	work	work	NOUN
ajst-938	7	5	reviews	review	VERB
ajst-938	7	6	the	the	DET
ajst-938	7	7	immunomodulation	immunomodulation	NOUN
ajst-938	7	8	approach	approach	NOUN
ajst-938	7	9	and	and	CCONJ
ajst-938	7	10	its	its	PRON
ajst-938	7	11	potential	potential	ADJ
ajst-938	7	12	application	application	NOUN
ajst-938	7	13	when	when	SCONJ
ajst-938	7	14	combined	combine	VERB
ajst-938	7	15	with	with	ADP
ajst-938	7	16	other	other	ADJ
ajst-938	7	17	therapies	therapy	NOUN
ajst-938	7	18	(	(	PUNCT
ajst-938	7	19	oncolytic	oncolytic	ADJ
ajst-938	7	20	virotherapy	virotherapy	NOUN
ajst-938	7	21	,	,	PUNCT
ajst-938	7	22	radiotherapy	radiotherapy	NOUN
ajst-938	7	23	,	,	PUNCT
ajst-938	7	24	physical	physical	ADJ
ajst-938	7	25	therapy	therapy	NOUN
ajst-938	7	26	)	)	PUNCT
ajst-938	7	27	.	.	PUNCT
ajst-938	8	1	keywords	keyword	NOUN
ajst-938	8	2	:	:	PUNCT
ajst-938	8	3	therapy	therapy	NOUN
ajst-938	8	4	,	,	PUNCT
ajst-938	8	5	breast	breast	NOUN
ajst-938	8	6	cancer	cancer	NOUN
ajst-938	8	7	,	,	PUNCT
ajst-938	8	8	treatment	treatment	NOUN
ajst-938	8	9	,	,	PUNCT
ajst-938	8	10	immunomodulation	immunomodulation	NOUN
ajst-938	8	11	,	,	PUNCT
ajst-938	8	12	immune	immune	ADJ
ajst-938	8	13	therapy	therapy	NOUN
ajst-938	8	14	.	.	PUNCT
ajst-938	9	1	1	1	X
ajst-938	9	2	.	.	X
ajst-938	9	3	introduction	introduction	NOUN
ajst-938	9	4	breast	breast	NOUN
ajst-938	9	5	cancer	cancer	NOUN
ajst-938	9	6	is	be	AUX
ajst-938	9	7	present	present	ADJ
ajst-938	9	8	as	as	ADP
ajst-938	9	9	a	a	DET
ajst-938	9	10	serious	serious	ADJ
ajst-938	9	11	threat	threat	NOUN
ajst-938	9	12	to	to	ADP
ajst-938	9	13	the	the	DET
ajst-938	9	14	health	health	NOUN
ajst-938	9	15	and	and	CCONJ
ajst-938	9	16	well	well	ADV
ajst-938	9	17	-	-	PUNCT
ajst-938	9	18	being	being	NOUN
ajst-938	9	19	of	of	ADP
ajst-938	9	20	women	woman	NOUN
ajst-938	9	21	in	in	ADP
ajst-938	9	22	the	the	DET
ajst-938	9	23	united	united	PROPN
ajst-938	9	24	states	states	PROPN
ajst-938	9	25	,	,	PUNCT
ajst-938	9	26	accounting	account	VERB
ajst-938	9	27	for	for	ADP
ajst-938	9	28	30	30	NUM
ajst-938	9	29	%	%	NOUN
ajst-938	9	30	of	of	ADP
ajst-938	9	31	all	all	DET
ajst-938	9	32	new	new	ADJ
ajst-938	9	33	cancer	cancer	NOUN
ajst-938	9	34	diagnosis	diagnosis	NOUN
ajst-938	9	35	and	and	CCONJ
ajst-938	9	36	almost	almost	ADV
ajst-938	9	37	41,000	41,000	NUM
ajst-938	9	38	deaths	death	NOUN
ajst-938	9	39	every	every	DET
ajst-938	9	40	year	year	NOUN
ajst-938	9	41	[	[	X
ajst-938	9	42	1	1	X
ajst-938	9	43	]	]	PUNCT
ajst-938	9	44	despite	despite	SCONJ
ajst-938	9	45	of	of	ADP
ajst-938	9	46	the	the	DET
ajst-938	9	47	38	38	NUM
ajst-938	9	48	%	%	NOUN
ajst-938	9	49	decrease	decrease	NOUN
ajst-938	9	50	in	in	ADP
ajst-938	9	51	the	the	DET
ajst-938	9	52	death	death	NOUN
ajst-938	9	53	rate	rate	NOUN
ajst-938	9	54	thanks	thank	NOUN
ajst-938	9	55	to	to	ADP
ajst-938	9	56	the	the	DET
ajst-938	9	57	progresses	progress	NOUN
ajst-938	9	58	made	make	VERB
ajst-938	9	59	in	in	ADP
ajst-938	9	60	the	the	DET
ajst-938	9	61	medical	medical	ADJ
ajst-938	9	62	field	field	NOUN
ajst-938	9	63	.	.	PUNCT
ajst-938	10	1	therefore	therefore	ADV
ajst-938	10	2	,	,	PUNCT
ajst-938	10	3	novel	novel	ADJ
ajst-938	10	4	approaches	approach	NOUN
ajst-938	10	5	of	of	ADP
ajst-938	10	6	breast	breast	NOUN
ajst-938	10	7	cancer	cancer	NOUN
ajst-938	10	8	therapy	therapy	NOUN
ajst-938	10	9	are	be	AUX
ajst-938	10	10	welcomed	welcome	VERB
ajst-938	10	11	that	that	SCONJ
ajst-938	10	12	lower	low	ADJ
ajst-938	10	13	the	the	DET
ajst-938	10	14	chance	chance	NOUN
ajst-938	10	15	of	of	ADP
ajst-938	10	16	relapse	relapse	NOUN
ajst-938	10	17	and	and	CCONJ
ajst-938	10	18	death	death	NOUN
ajst-938	10	19	for	for	ADP
ajst-938	10	20	this	this	DET
ajst-938	10	21	disease	disease	NOUN
ajst-938	10	22	.	.	PUNCT
ajst-938	11	1	in	in	ADP
ajst-938	11	2	recent	recent	ADJ
ajst-938	11	3	years	year	NOUN
ajst-938	11	4	,	,	PUNCT
ajst-938	11	5	mounting	mount	VERB
ajst-938	11	6	evidence	evidence	NOUN
ajst-938	11	7	supports	support	VERB
ajst-938	11	8	a	a	DET
ajst-938	11	9	key	key	ADJ
ajst-938	11	10	role	role	NOUN
ajst-938	11	11	for	for	ADP
ajst-938	11	12	the	the	DET
ajst-938	11	13	immune	immune	ADJ
ajst-938	11	14	system	system	NOUN
ajst-938	11	15	in	in	ADP
ajst-938	11	16	determining	determine	VERB
ajst-938	11	17	response	response	NOUN
ajst-938	11	18	to	to	ADP
ajst-938	11	19	standard	standard	ADJ
ajst-938	11	20	therapy	therapy	NOUN
ajst-938	11	21	and	and	CCONJ
ajst-938	11	22	longterm	longterm	ADJ
ajst-938	11	23	survival	survival	NOUN
ajst-938	11	24	in	in	ADP
ajst-938	11	25	patients	patient	NOUN
ajst-938	11	26	with	with	ADP
ajst-938	11	27	breast	breast	NOUN
ajst-938	11	28	cancer	cancer	NOUN
ajst-938	11	29	.	.	PUNCT
ajst-938	12	1	data	datum	NOUN
ajst-938	12	2	and	and	CCONJ
ajst-938	12	3	the	the	DET
ajst-938	12	4	clinical	clinical	ADJ
ajst-938	12	5	success	success	NOUN
ajst-938	12	6	of	of	ADP
ajst-938	12	7	immunomodulation	immunomodulation	NOUN
ajst-938	12	8	to	to	ADP
ajst-938	12	9	tumors	tumor	NOUN
ajst-938	12	10	have	have	AUX
ajst-938	12	11	reignited	reignite	VERB
ajst-938	12	12	interest	interest	NOUN
ajst-938	12	13	in	in	ADP
ajst-938	12	14	immune	immune	NOUN
ajst-938	12	15	-	-	PUNCT
ajst-938	12	16	based	base	VERB
ajst-938	12	17	strategies	strategy	NOUN
ajst-938	12	18	for	for	ADP
ajst-938	12	19	breast	breast	NOUN
ajst-938	12	20	cancer	cancer	NOUN
ajst-938	12	21	treatment	treatment	NOUN
ajst-938	12	22	.	.	PUNCT
ajst-938	13	1	this	this	DET
ajst-938	13	2	review	review	NOUN
ajst-938	13	3	would	would	AUX
ajst-938	13	4	focus	focus	VERB
ajst-938	13	5	on	on	ADP
ajst-938	13	6	immunomodulation	immunomodulation	NOUN
ajst-938	13	7	,	,	PUNCT
ajst-938	13	8	as	as	ADP
ajst-938	13	9	a	a	DET
ajst-938	13	10	branched	branched	ADJ
ajst-938	13	11	approach	approach	NOUN
ajst-938	13	12	under	under	ADP
ajst-938	13	13	immune	immune	ADJ
ajst-938	13	14	therapy	therapy	NOUN
ajst-938	13	15	,	,	PUNCT
ajst-938	13	16	and	and	CCONJ
ajst-938	13	17	divides	divide	VERB
ajst-938	13	18	it	it	PRON
ajst-938	13	19	into	into	ADP
ajst-938	13	20	two	two	NUM
ajst-938	13	21	parts	part	NOUN
ajst-938	13	22	,	,	PUNCT
ajst-938	13	23	immunomodulation	immunomodulation	NOUN
ajst-938	13	24	being	be	AUX
ajst-938	13	25	used	use	VERB
ajst-938	13	26	as	as	ADP
ajst-938	13	27	a	a	DET
ajst-938	13	28	stand	stand	NOUN
ajst-938	13	29	alone	alone	ADV
ajst-938	13	30	therapy	therapy	NOUN
ajst-938	13	31	and	and	CCONJ
ajst-938	13	32	in	in	ADP
ajst-938	13	33	combination	combination	NOUN
ajst-938	13	34	with	with	ADP
ajst-938	13	35	other	other	ADJ
ajst-938	13	36	therapies	therapy	NOUN
ajst-938	13	37	,	,	PUNCT
ajst-938	13	38	which	which	PRON
ajst-938	13	39	altogether	altogether	ADV
ajst-938	13	40	can	can	AUX
ajst-938	13	41	elicit	elicit	VERB
ajst-938	13	42	a	a	DET
ajst-938	13	43	greater	great	ADJ
ajst-938	13	44	immune	immune	ADJ
ajst-938	13	45	response	response	NOUN
ajst-938	13	46	.	.	PUNCT
ajst-938	14	1	2	2	X
ajst-938	14	2	.	.	X
ajst-938	14	3	stand	stand	VERB
ajst-938	14	4	alone	alone	ADV
ajst-938	14	5	therapy	therapy	NOUN
ajst-938	14	6	2.1	2.1	NUM
ajst-938	14	7	.	.	PUNCT
ajst-938	15	1	ex	ex	PRON
ajst-938	15	2	vivo	vivo	ADJ
ajst-938	15	3	gene	gene	NOUN
ajst-938	15	4	therapy	therapy	NOUN
ajst-938	15	5	basically	basically	ADV
ajst-938	15	6	,	,	PUNCT
ajst-938	15	7	immune	immune	ADJ
ajst-938	15	8	therapy	therapy	NOUN
ajst-938	15	9	relies	rely	VERB
ajst-938	15	10	on	on	ADP
ajst-938	15	11	the	the	DET
ajst-938	15	12	ability	ability	NOUN
ajst-938	15	13	of	of	ADP
ajst-938	15	14	the	the	DET
ajst-938	15	15	immune	immune	ADJ
ajst-938	15	16	system	system	NOUN
ajst-938	15	17	to	to	PART
ajst-938	15	18	identify	identify	VERB
ajst-938	15	19	and	and	CCONJ
ajst-938	15	20	destroy	destroy	VERB
ajst-938	15	21	tumor	tumor	NOUN
ajst-938	15	22	cells	cell	NOUN
ajst-938	15	23	and	and	CCONJ
ajst-938	15	24	to	to	PART
ajst-938	15	25	elicit	elicit	VERB
ajst-938	15	26	a	a	DET
ajst-938	15	27	long	long	ADV
ajst-938	15	28	lasting	last	VERB
ajst-938	15	29	memory	memory	NOUN
ajst-938	15	30	of	of	ADP
ajst-938	15	31	this	this	DET
ajst-938	15	32	interaction	interaction	NOUN
ajst-938	15	33	.	.	PUNCT
ajst-938	16	1	under	under	ADP
ajst-938	16	2	normal	normal	ADJ
ajst-938	16	3	circumstances	circumstance	NOUN
ajst-938	16	4	,	,	PUNCT
ajst-938	16	5	however	however	ADV
ajst-938	16	6	,	,	PUNCT
ajst-938	16	7	the	the	DET
ajst-938	16	8	ability	ability	NOUN
ajst-938	16	9	of	of	ADP
ajst-938	16	10	tumor	tumor	NOUN
ajst-938	16	11	cells	cell	NOUN
ajst-938	16	12	to	to	PART
ajst-938	16	13	trigger	trigger	VERB
ajst-938	16	14	an	an	DET
ajst-938	16	15	effective	effective	ADJ
ajst-938	16	16	immune	immune	ADJ
ajst-938	16	17	response	response	NOUN
ajst-938	16	18	is	be	AUX
ajst-938	16	19	limited	limited	ADJ
ajst-938	16	20	.	.	PUNCT
ajst-938	17	1	the	the	DET
ajst-938	17	2	rather	rather	ADV
ajst-938	17	3	poor	poor	ADJ
ajst-938	17	4	immuno	immuno	NOUN
ajst-938	17	5	-	-	PUNCT
ajst-938	17	6	genicity	genicity	NOUN
ajst-938	17	7	of	of	ADP
ajst-938	17	8	tumor	tumor	NOUN
ajst-938	17	9	cells	cell	NOUN
ajst-938	17	10	results	result	NOUN
ajst-938	17	11	in	in	ADP
ajst-938	17	12	part	part	NOUN
ajst-938	17	13	from	from	ADP
ajst-938	17	14	their	their	PRON
ajst-938	17	15	weak	weak	ADJ
ajst-938	17	16	expression	expression	NOUN
ajst-938	17	17	of	of	ADP
ajst-938	17	18	cytokines	cytokine	NOUN
ajst-938	17	19	that	that	PRON
ajst-938	17	20	could	could	AUX
ajst-938	17	21	allow	allow	VERB
ajst-938	17	22	t	t	NOUN
ajst-938	17	23	-	-	PUNCT
ajst-938	17	24	cell	cell	NOUN
ajst-938	17	25	activation	activation	NOUN
ajst-938	17	26	.	.	PUNCT
ajst-938	18	1	in	in	ADP
ajst-938	18	2	addition	addition	NOUN
ajst-938	18	3	,	,	PUNCT
ajst-938	18	4	tumors	tumor	NOUN
ajst-938	18	5	may	may	AUX
ajst-938	18	6	also	also	ADV
ajst-938	18	7	secrete	secrete	VERB
ajst-938	18	8	immunosuppressive	immunosuppressive	ADJ
ajst-938	18	9	molecules	molecule	NOUN
ajst-938	18	10	,	,	PUNCT
ajst-938	18	11	which	which	PRON
ajst-938	18	12	often	often	ADV
ajst-938	18	13	fail	fail	VERB
ajst-938	18	14	to	to	PART
ajst-938	18	15	express	express	VERB
ajst-938	18	16	cytokines	cytokine	NOUN
ajst-938	18	17	that	that	PRON
ajst-938	18	18	activate	activate	VERB
ajst-938	18	19	local	local	ADJ
ajst-938	18	20	immune	immune	ADJ
ajst-938	18	21	responses	response	NOUN
ajst-938	18	22	[	[	X
ajst-938	18	23	2	2	NUM
ajst-938	18	24	]	]	PUNCT
ajst-938	18	25	.	.	PUNCT
ajst-938	19	1	generally	generally	ADV
ajst-938	19	2	,	,	PUNCT
ajst-938	19	3	a	a	DET
ajst-938	19	4	lack	lack	NOUN
ajst-938	19	5	of	of	ADP
ajst-938	19	6	local	local	ADJ
ajst-938	19	7	cytokines	cytokine	NOUN
ajst-938	19	8	accounts	account	VERB
ajst-938	19	9	for	for	ADP
ajst-938	19	10	this	this	DET
ajst-938	19	11	poor	poor	ADJ
ajst-938	19	12	immuno	immuno	NOUN
ajst-938	19	13	-	-	PUNCT
ajst-938	19	14	genicity	genicity	NOUN
ajst-938	19	15	.	.	PUNCT
ajst-938	20	1	this	this	DET
ajst-938	20	2	problem	problem	NOUN
ajst-938	20	3	can	can	AUX
ajst-938	20	4	be	be	AUX
ajst-938	20	5	addressed	address	VERB
ajst-938	20	6	by	by	ADP
ajst-938	20	7	introducing	introduce	VERB
ajst-938	20	8	immunomodulatory	immunomodulatory	ADJ
ajst-938	20	9	molecules	molecule	NOUN
ajst-938	20	10	or	or	CCONJ
ajst-938	20	11	genes	gene	NOUN
ajst-938	20	12	into	into	ADP
ajst-938	20	13	the	the	DET
ajst-938	20	14	tumor	tumor	NOUN
ajst-938	20	15	.	.	PUNCT
ajst-938	21	1	this	this	DET
ajst-938	21	2	immunomodulatory	immunomodulatory	ADJ
ajst-938	21	3	approach	approach	NOUN
ajst-938	21	4	of	of	ADP
ajst-938	21	5	introducing	introduce	VERB
ajst-938	21	6	cytokines	cytokine	NOUN
ajst-938	21	7	genes	gene	NOUN
ajst-938	21	8	into	into	ADP
ajst-938	21	9	tumor	tumor	NOUN
ajst-938	21	10	cells	cell	NOUN
ajst-938	21	11	is	be	AUX
ajst-938	21	12	called	call	VERB
ajst-938	21	13	ex	ex	PRON
ajst-938	21	14	vivo	vivo	ADJ
ajst-938	21	15	gene	gene	NOUN
ajst-938	21	16	therapy	therapy	NOUN
ajst-938	21	17	.	.	PUNCT
ajst-938	22	1	it	it	PRON
ajst-938	22	2	allows	allow	VERB
ajst-938	22	3	a	a	DET
ajst-938	22	4	sustained	sustained	ADJ
ajst-938	22	5	local	local	ADJ
ajst-938	22	6	release	release	NOUN
ajst-938	22	7	of	of	ADP
ajst-938	22	8	cytokines	cytokine	NOUN
ajst-938	22	9	capable	capable	ADJ
ajst-938	22	10	of	of	ADP
ajst-938	22	11	enhancing	enhance	VERB
ajst-938	22	12	the	the	DET
ajst-938	22	13	intensity	intensity	NOUN
ajst-938	22	14	and	and	CCONJ
ajst-938	22	15	quality	quality	NOUN
ajst-938	22	16	of	of	ADP
ajst-938	22	17	the	the	DET
ajst-938	22	18	immune	immune	ADJ
ajst-938	22	19	response	response	NOUN
ajst-938	22	20	to	to	ADP
ajst-938	22	21	tumor	tumor	NOUN
ajst-938	22	22	.	.	PUNCT
ajst-938	23	1	studies	study	NOUN
ajst-938	23	2	in	in	ADP
ajst-938	23	3	various	various	ADJ
ajst-938	23	4	breast	breast	NOUN
ajst-938	23	5	tumor	tumor	NOUN
ajst-938	23	6	models	model	NOUN
ajst-938	23	7	have	have	AUX
ajst-938	23	8	proved	prove	VERB
ajst-938	23	9	this	this	DET
ajst-938	23	10	sole	sole	ADJ
ajst-938	23	11	immunomodulation	immunomodulation	NOUN
ajst-938	23	12	to	to	PART
ajst-938	23	13	be	be	AUX
ajst-938	23	14	effective	effective	ADJ
ajst-938	23	15	.	.	PUNCT
ajst-938	24	1	they	they	PRON
ajst-938	24	2	show	show	VERB
ajst-938	24	3	that	that	SCONJ
ajst-938	24	4	the	the	DET
ajst-938	24	5	introduction	introduction	NOUN
ajst-938	24	6	into	into	ADP
ajst-938	24	7	hosts	host	NOUN
ajst-938	24	8	of	of	ADP
ajst-938	24	9	tumor	tumor	NOUN
ajst-938	24	10	cells	cell	NOUN
ajst-938	24	11	secreting	secrete	VERB
ajst-938	24	12	cytokines	cytokine	NOUN
ajst-938	24	13	,	,	PUNCT
ajst-938	24	14	such	such	ADJ
ajst-938	24	15	as	as	ADP
ajst-938	24	16	il-1	il-1	X
ajst-938	24	17	,	,	PUNCT
ajst-938	24	18	-2	-2	INTJ
ajst-938	24	19	,	,	PUNCT
ajst-938	24	20	-4	-4	INTJ
ajst-938	24	21	,	,	PUNCT
ajst-938	24	22	-6	-6	INTJ
ajst-938	24	23	,	,	PUNCT
ajst-938	24	24	-7	-7	NOUN
ajst-938	24	25	,	,	PUNCT
ajst-938	24	26	12	12	NUM
ajst-938	24	27	,	,	PUNCT
ajst-938	24	28	-18	-18	PROPN
ajst-938	24	29	,	,	PUNCT
ajst-938	24	30	as	as	ADV
ajst-938	24	31	well	well	ADV
ajst-938	24	32	as	as	ADP
ajst-938	24	33	tnf	tnf	PROPN
ajst-938	24	34	-	-	PUNCT
ajst-938	24	35	α	α	PROPN
ajst-938	24	36	,	,	PUNCT
ajst-938	24	37	g	g	NOUN
ajst-938	24	38	-	-	PUNCT
ajst-938	24	39	csf	csf	NOUN
ajst-938	24	40	,	,	PUNCT
ajst-938	24	41	gm	gm	PROPN
ajst-938	24	42	-	-	PUNCT
ajst-938	24	43	csf	csf	PROPN
ajst-938	24	44	,	,	PUNCT
ajst-938	24	45	or	or	CCONJ
ajst-938	24	46	ifn	ifn	PROPN
ajst-938	24	47	-	-	PUNCT
ajst-938	24	48	γ	γ	NOUN
ajst-938	24	49	,	,	PUNCT
ajst-938	24	50	can	can	AUX
ajst-938	24	51	lead	lead	VERB
ajst-938	24	52	to	to	ADP
ajst-938	24	53	successful	successful	ADJ
ajst-938	24	54	tumor	tumor	NOUN
ajst-938	24	55	rejection	rejection	NOUN
ajst-938	24	56	by	by	ADP
ajst-938	24	57	stimulating	stimulate	VERB
ajst-938	24	58	anti	anti	ADJ
ajst-938	24	59	-	-	ADJ
ajst-938	24	60	tumor	tumor	ADJ
ajst-938	24	61	responses	response	NOUN
ajst-938	24	62	.	.	PUNCT
ajst-938	25	1	rejection	rejection	NOUN
ajst-938	25	2	depends	depend	VERB
ajst-938	25	3	on	on	ADP
ajst-938	25	4	a	a	DET
ajst-938	25	5	high	high	ADJ
ajst-938	25	6	level	level	NOUN
ajst-938	25	7	of	of	ADP
ajst-938	25	8	cytokines	cytokine	NOUN
ajst-938	25	9	production	production	NOUN
ajst-938	25	10	by	by	ADP
ajst-938	25	11	the	the	DET
ajst-938	25	12	gene	gene	NOUN
ajst-938	25	13	-	-	PUNCT
ajst-938	25	14	modified	modify	VERB
ajst-938	25	15	cells	cell	NOUN
ajst-938	25	16	and	and	CCONJ
ajst-938	25	17	is	be	AUX
ajst-938	25	18	due	due	ADJ
ajst-938	25	19	in	in	ADP
ajst-938	25	20	part	part	NOUN
ajst-938	25	21	to	to	ADP
ajst-938	25	22	stimulation	stimulation	NOUN
ajst-938	25	23	of	of	ADP
ajst-938	25	24	host	host	NOUN
ajst-938	25	25	anti	anti	ADJ
ajst-938	25	26	-	-	ADJ
ajst-938	25	27	tumor	tumor	ADJ
ajst-938	25	28	effector	effector	NOUN
ajst-938	25	29	response	response	NOUN
ajst-938	25	30	[	[	X
ajst-938	25	31	3	3	NUM
ajst-938	25	32	,	,	PUNCT
ajst-938	25	33	4	4	NUM
ajst-938	25	34	]	]	PUNCT
ajst-938	25	35	.	.	PUNCT
ajst-938	26	1	in	in	ADP
ajst-938	26	2	some	some	DET
ajst-938	26	3	circumstances	circumstance	NOUN
ajst-938	26	4	,	,	PUNCT
ajst-938	26	5	it	it	PRON
ajst-938	26	6	allowed	allow	VERB
ajst-938	26	7	the	the	DET
ajst-938	26	8	complete	complete	ADJ
ajst-938	26	9	rejection	rejection	NOUN
ajst-938	26	10	of	of	ADP
ajst-938	26	11	tumor	tumor	NOUN
ajst-938	26	12	and	and	CCONJ
ajst-938	26	13	even	even	ADV
ajst-938	26	14	protected	protect	VERB
ajst-938	26	15	the	the	DET
ajst-938	26	16	host	host	NOUN
ajst-938	26	17	against	against	ADP
ajst-938	26	18	subsequent	subsequent	ADJ
ajst-938	26	19	challenge	challenge	NOUN
ajst-938	26	20	with	with	ADP
ajst-938	26	21	unmodified	unmodified	ADJ
ajst-938	26	22	tumor	tumor	NOUN
ajst-938	26	23	cells	cell	NOUN
ajst-938	26	24	[	[	X
ajst-938	26	25	5	5	NUM
ajst-938	26	26	]	]	PUNCT
ajst-938	26	27	.	.	PUNCT
ajst-938	27	1	3	3	X
ajst-938	27	2	.	.	X
ajst-938	27	3	combination	combination	NOUN
ajst-938	27	4	3.1	3.1	NUM
ajst-938	27	5	.	.	PUNCT
ajst-938	28	1	oncolytic	oncolytic	ADJ
ajst-938	28	2	virotherapy	virotherapy	PROPN
ajst-938	28	3	oncolytic	oncolytic	ADJ
ajst-938	28	4	viruses	virus	NOUN
ajst-938	28	5	are	be	AUX
ajst-938	28	6	attenuated	attenuate	VERB
ajst-938	28	7	,	,	PUNCT
ajst-938	28	8	mutated	mutate	VERB
ajst-938	28	9	,	,	PUNCT
ajst-938	28	10	or	or	CCONJ
ajst-938	28	11	benign	benign	ADJ
ajst-938	28	12	viruses	virus	NOUN
ajst-938	28	13	that	that	PRON
ajst-938	28	14	preferentially	preferentially	ADV
ajst-938	28	15	target	target	VERB
ajst-938	28	16	cancer	cancer	NOUN
ajst-938	28	17	cells	cell	NOUN
ajst-938	28	18	and	and	CCONJ
ajst-938	28	19	do	do	AUX
ajst-938	28	20	not	not	PART
ajst-938	28	21	infect	infect	VERB
ajst-938	28	22	normal	normal	ADJ
ajst-938	28	23	,	,	PUNCT
ajst-938	28	24	non	non	ADJ
ajst-938	28	25	-	-	ADJ
ajst-938	28	26	transformed	transform	VERB
ajst-938	28	27	cells	cell	NOUN
ajst-938	28	28	.	.	PUNCT
ajst-938	29	1	therefore	therefore	ADV
ajst-938	29	2	,	,	PUNCT
ajst-938	29	3	the	the	DET
ajst-938	29	4	key	key	ADJ
ajst-938	29	5	desirable	desirable	ADJ
ajst-938	29	6	characteristics	characteristic	NOUN
ajst-938	29	7	of	of	ADP
ajst-938	29	8	oncolytic	oncolytic	ADJ
ajst-938	29	9	viruses	virus	NOUN
ajst-938	29	10	are	be	AUX
ajst-938	29	11	the	the	DET
ajst-938	29	12	specificity	specificity	NOUN
ajst-938	29	13	for	for	ADP
ajst-938	29	14	the	the	DET
ajst-938	29	15	targeted	target	VERB
ajst-938	29	16	cancer	cancer	NOUN
ajst-938	29	17	cells	cell	NOUN
ajst-938	29	18	,	,	PUNCT
ajst-938	29	19	their	their	PRON
ajst-938	29	20	potency	potency	NOUN
ajst-938	29	21	to	to	PART
ajst-938	29	22	induce	induce	VERB
ajst-938	29	23	cell	cell	NOUN
ajst-938	29	24	death	death	NOUN
ajst-938	29	25	and	and	CCONJ
ajst-938	29	26	safety	safety	NOUN
ajst-938	29	27	to	to	PART
ajst-938	29	28	avoid	avoid	VERB
ajst-938	29	29	adverse	adverse	ADJ
ajst-938	29	30	reactions	reaction	NOUN
ajst-938	29	31	and	and	CCONJ
ajst-938	29	32	reversion	reversion	NOUN
ajst-938	29	33	[	[	X
ajst-938	29	34	6	6	NUM
ajst-938	29	35	]	]	PUNCT
ajst-938	29	36	.	.	PUNCT
ajst-938	30	1	it	it	PRON
ajst-938	30	2	is	be	AUX
ajst-938	30	3	true	true	ADJ
ajst-938	30	4	that	that	SCONJ
ajst-938	30	5	there	there	PRON
ajst-938	30	6	are	be	VERB
ajst-938	30	7	numerous	numerous	ADJ
ajst-938	30	8	naturally	naturally	ADV
ajst-938	30	9	occurring	occur	VERB
ajst-938	30	10	oncolytic	oncolytic	ADJ
ajst-938	30	11	viruses	virus	NOUN
ajst-938	30	12	exist	exist	VERB
ajst-938	30	13	in	in	ADP
ajst-938	30	14	our	our	PRON
ajst-938	30	15	body	body	NOUN
ajst-938	30	16	,	,	PUNCT
ajst-938	30	17	but	but	CCONJ
ajst-938	30	18	recently	recently	ADV
ajst-938	30	19	more	more	ADJ
ajst-938	30	20	researchers	researcher	NOUN
ajst-938	30	21	are	be	AUX
ajst-938	30	22	revolving	revolve	VERB
ajst-938	30	23	around	around	ADP
ajst-938	30	24	genetically	genetically	ADV
ajst-938	30	25	modified	modify	VERB
ajst-938	30	26	viruses	virus	NOUN
ajst-938	30	27	to	to	PART
ajst-938	30	28	improve	improve	VERB
ajst-938	30	29	their	their	PRON
ajst-938	30	30	safety	safety	NOUN
ajst-938	30	31	,	,	PUNCT
ajst-938	30	32	specificity	specificity	NOUN
ajst-938	30	33	,	,	PUNCT
ajst-938	30	34	immunogenicity	immunogenicity	NOUN
ajst-938	30	35	,	,	PUNCT
ajst-938	30	36	oncolytic	oncolytic	ADJ
ajst-938	30	37	potency	potency	NOUN
ajst-938	30	38	,	,	PUNCT
ajst-938	30	39	and	and	CCONJ
ajst-938	30	40	drugability	drugability	NOUN
ajst-938	31	1	[	[	X
ajst-938	31	2	6	6	NUM
ajst-938	31	3	]	]	PUNCT
ajst-938	31	4	.	.	PUNCT
ajst-938	32	1	and	and	CCONJ
ajst-938	32	2	this	this	DET
ajst-938	32	3	improvement	improvement	NOUN
ajst-938	32	4	is	be	AUX
ajst-938	32	5	attained	attain	VERB
ajst-938	32	6	by	by	ADP
ajst-938	32	7	combining	combine	VERB
ajst-938	32	8	clinical	clinical	ADJ
ajst-938	32	9	related	related	ADJ
ajst-938	32	10	oncolytic	oncolytic	ADJ
ajst-938	32	11	viruses	virus	NOUN
ajst-938	32	12	with	with	ADP
ajst-938	32	13	one	one	NUM
ajst-938	32	14	or	or	CCONJ
ajst-938	32	15	more	more	ADJ
ajst-938	32	16	immunomodulating	immunomodulating	ADJ
ajst-938	32	17	factors	factor	NOUN
ajst-938	32	18	,	,	PUNCT
ajst-938	32	19	letting	let	VERB
ajst-938	32	20	oncolytic	oncolytic	ADJ
ajst-938	32	21	viruses	virus	NOUN
ajst-938	32	22	be	be	AUX
ajst-938	32	23	genetically	genetically	ADV
ajst-938	32	24	modified	modify	VERB
ajst-938	32	25	.	.	PUNCT
ajst-938	33	1	an	an	DET
ajst-938	33	2	example	example	NOUN
ajst-938	33	3	of	of	ADP
ajst-938	33	4	this	this	DET
ajst-938	33	5	combination	combination	NOUN
ajst-938	33	6	is	be	AUX
ajst-938	33	7	the	the	DET
ajst-938	33	8	granulocyte	granulocyte	ADJ
ajst-938	33	9	macrophage	macrophage	NOUN
ajst-938	33	10	—	—	PUNCT
ajst-938	33	11	colony	colony	NOUN
ajst-938	33	12	stimulating	stimulate	VERB
ajst-938	33	13	factor	factor	NOUN
ajst-938	33	14	(	(	PUNCT
ajst-938	33	15	gm	gm	NOUN
ajst-938	33	16	-	-	PUNCT
ajst-938	33	17	csf	csf	NOUN
ajst-938	33	18	)	)	PUNCT
ajst-938	33	19	and	and	CCONJ
ajst-938	33	20	oncolytic	oncolytic	ADJ
ajst-938	33	21	viruses	virus	NOUN
ajst-938	33	22	.	.	PUNCT
ajst-938	34	1	using	use	VERB
ajst-938	34	2	oncolytic	oncolytic	ADJ
ajst-938	34	3	viruses	virus	NOUN
ajst-938	34	4	engineered	engineer	VERB
ajst-938	34	5	to	to	PART
ajst-938	34	6	express	express	VERB
ajst-938	34	7	cytokines	cytokine	NOUN
ajst-938	34	8	to	to	PART
ajst-938	34	9	increase	increase	VERB
ajst-938	34	10	the	the	DET
ajst-938	34	11	number	number	NOUN
ajst-938	34	12	of	of	ADP
ajst-938	34	13	antigen	antigen	NOUN
ajst-938	34	14	presenting	present	VERB
ajst-938	34	15	cells	cell	NOUN
ajst-938	34	16	at	at	ADP
ajst-938	34	17	the	the	DET
ajst-938	34	18	tumor	tumor	NOUN
ajst-938	34	19	site	site	NOUN
ajst-938	34	20	is	be	AUX
ajst-938	34	21	proved	prove	VERB
ajst-938	34	22	to	to	PART
ajst-938	34	23	be	be	AUX
ajst-938	34	24	a	a	DET
ajst-938	34	25	solid	solid	ADJ
ajst-938	34	26	strategy	strategy	NOUN
ajst-938	34	27	to	to	PART
ajst-938	34	28	enhance	enhance	VERB
ajst-938	34	29	the	the	DET
ajst-938	34	30	anti	anti	ADJ
ajst-938	34	31	-	-	ADJ
ajst-938	34	32	tumor	tumor	ADJ
ajst-938	34	33	effect	effect	NOUN
ajst-938	34	34	of	of	ADP
ajst-938	34	35	oncolytic	oncolytic	ADJ
ajst-938	34	36	viruses	virus	NOUN
ajst-938	34	37	.	.	PUNCT
ajst-938	35	1	t	t	PROPN
ajst-938	35	2	-	-	PUNCT
ajst-938	35	3	vec	vec	PROPN
ajst-938	35	4	,	,	PUNCT
ajst-938	35	5	an	an	DET
ajst-938	35	6	attenuated	attenuate	VERB
ajst-938	35	7	herpes	herpe	NOUN
ajst-938	35	8	simplex	simplex	NOUN
ajst-938	35	9	virus	virus	NOUN
ajst-938	35	10	incorporating	incorporate	VERB
ajst-938	35	11	a	a	DET
ajst-938	35	12	gm	gm	NOUN
ajst-938	35	13	-	-	PUNCT
ajst-938	35	14	csf	csf	ADJ
ajst-938	35	15	trans	trans	PROPN
ajst-938	35	16	gene	gene	NOUN
ajst-938	35	17	,	,	PUNCT
ajst-938	35	18	was	be	AUX
ajst-938	35	19	granted	grant	VERB
ajst-938	35	20	marketing	marketing	NOUN
ajst-938	35	21	approval	approval	NOUN
ajst-938	35	22	by	by	ADP
ajst-938	35	23	fda	fda	PROPN
ajst-938	35	24	and	and	CCONJ
ajst-938	35	25	ema	ema	PROPN
ajst-938	35	26	in	in	ADP
ajst-938	35	27	2015	2015	NUM
ajst-938	35	28	for	for	ADP
ajst-938	35	29	it	it	PRON
ajst-938	35	30	therapy	therapy	NOUN
ajst-938	35	31	in	in	ADP
ajst-938	35	32	patients	patient	NOUN
ajst-938	35	33	with	with	ADP
ajst-938	35	34	stage	stage	NOUN
ajst-938	35	35	3	3	NUM
ajst-938	35	36	and	and	CCONJ
ajst-938	35	37	4	4	NUM
ajst-938	35	38	melanoma	melanoma	NOUN
ajst-938	35	39	[	[	X
ajst-938	35	40	7	7	NUM
ajst-938	35	41	]	]	PUNCT
ajst-938	35	42	.	.	PUNCT
ajst-938	36	1	similarly	similarly	ADV
ajst-938	36	2	,	,	PUNCT
ajst-938	36	3	a	a	DET
ajst-938	36	4	vaccinia	vaccinia	NOUN
ajst-938	36	5	virus	virus	NOUN
ajst-938	36	6	engineered	engineer	VERB
ajst-938	36	7	to	to	PART
ajst-938	36	8	express	express	VERB
ajst-938	36	9	gm	gm	PROPN
ajst-938	36	10	-	-	PUNCT
ajst-938	36	11	csf	csf	PROPN
ajst-938	36	12	,	,	PUNCT
ajst-938	36	13	jx-594	jx-594	NOUN
ajst-938	36	14	,	,	PUNCT
ajst-938	36	15	has	have	AUX
ajst-938	36	16	been	be	AUX
ajst-938	36	17	shown	show	VERB
ajst-938	36	18	to	to	PART
ajst-938	36	19	have	have	VERB
ajst-938	36	20	an	an	DET
ajst-938	36	21	enhanced	enhance	VERB
ajst-938	36	22	capability	capability	NOUN
ajst-938	36	23	in	in	ADP
ajst-938	36	24	selectively	selectively	ADV
ajst-938	36	25	targeting	target	VERB
ajst-938	36	26	and	and	CCONJ
ajst-938	36	27	replicating	replicate	VERB
ajst-938	36	28	in	in	ADP
ajst-938	36	29	tumor	tumor	NOUN
ajst-938	36	30	cells	cell	NOUN
ajst-938	36	31	and	and	CCONJ
ajst-938	36	32	has	have	VERB
ajst-938	36	33	anti	anti	ADJ
ajst-938	36	34	-	-	ADJ
ajst-938	36	35	tumor	tumor	ADJ
ajst-938	36	36	efficacy	efficacy	NOUN
ajst-938	36	37	in	in	ADP
ajst-938	36	38	both	both	CCONJ
ajst-938	36	39	a	a	DET
ajst-938	36	40	preclinical	preclinical	ADJ
ajst-938	36	41	and	and	CCONJ
ajst-938	36	42	clinical	clinical	ADJ
ajst-938	36	43	setting	setting	NOUN
ajst-938	36	44	[	[	X
ajst-938	36	45	8	8	NUM
ajst-938	36	46	]	]	SYM
ajst-938	36	47	.	.	PUNCT
ajst-938	37	1	3.2	3.2	NUM
ajst-938	37	2	.	.	PUNCT
ajst-938	37	3	radiotherapy	radiotherapy	NOUN
ajst-938	37	4	currently	currently	ADV
ajst-938	37	5	,	,	PUNCT
ajst-938	37	6	radiotherapy	radiotherapy	NOUN
ajst-938	37	7	is	be	AUX
ajst-938	37	8	the	the	DET
ajst-938	37	9	frontline	frontline	NOUN
ajst-938	37	10	therapy	therapy	NOUN
ajst-938	37	11	for	for	ADP
ajst-938	37	12	approximately	approximately	ADV
ajst-938	37	13	50	50	NUM
ajst-938	37	14	%	%	NOUN
ajst-938	37	15	of	of	ADP
ajst-938	37	16	all	all	DET
ajst-938	37	17	patients	patient	NOUN
ajst-938	37	18	with	with	ADP
ajst-938	37	19	newly	newly	ADV
ajst-938	37	20	diagnosed	diagnose	VERB
ajst-938	37	21	137	137	NUM
ajst-938	37	22	cancer	cancer	NOUN
ajst-938	37	23	,	,	PUNCT
ajst-938	37	24	alone	alone	ADJ
ajst-938	37	25	or	or	CCONJ
ajst-938	37	26	in	in	ADP
ajst-938	37	27	combination	combination	NOUN
ajst-938	37	28	with	with	ADP
ajst-938	37	29	surgery	surgery	NOUN
ajst-938	37	30	or	or	CCONJ
ajst-938	37	31	chemotherapy	chemotherapy	NOUN
ajst-938	37	32	[	[	X
ajst-938	37	33	9	9	NUM
ajst-938	37	34	]	]	PUNCT
ajst-938	37	35	.	.	PUNCT
ajst-938	38	1	recent	recent	ADJ
ajst-938	38	2	advances	advance	NOUN
ajst-938	38	3	in	in	ADP
ajst-938	38	4	radiotherapy	radiotherapy	NOUN
ajst-938	38	5	technologies	technology	NOUN
ajst-938	38	6	and	and	CCONJ
ajst-938	38	7	approaches	approach	NOUN
ajst-938	38	8	have	have	AUX
ajst-938	38	9	focused	focus	VERB
ajst-938	38	10	on	on	ADP
ajst-938	38	11	limiting	limit	VERB
ajst-938	38	12	toxicity	toxicity	NOUN
ajst-938	38	13	and	and	CCONJ
ajst-938	38	14	on	on	ADP
ajst-938	38	15	achieving	achieve	VERB
ajst-938	38	16	greater	great	ADJ
ajst-938	38	17	therapeutic	therapeutic	ADJ
ajst-938	38	18	effectiveness	effectiveness	NOUN
ajst-938	38	19	.	.	PUNCT
ajst-938	39	1	the	the	DET
ajst-938	39	2	radiation	radiation	NOUN
ajst-938	39	3	comes	come	VERB
ajst-938	39	4	principally	principally	ADV
ajst-938	39	5	in	in	ADP
ajst-938	39	6	x	x	PROPN
ajst-938	39	7	rays	ray	NOUN
ajst-938	39	8	that	that	PRON
ajst-938	39	9	causes	cause	VERB
ajst-938	39	10	the	the	DET
ajst-938	39	11	induction	induction	NOUN
ajst-938	39	12	of	of	ADP
ajst-938	39	13	dna	dna	PROPN
ajst-938	39	14	damage	damage	NOUN
ajst-938	39	15	,	,	PUNCT
ajst-938	39	16	which	which	PRON
ajst-938	39	17	can	can	AUX
ajst-938	39	18	result	result	VERB
ajst-938	39	19	in	in	ADP
ajst-938	39	20	tumor	tumor	NOUN
ajst-938	39	21	cell	cell	NOUN
ajst-938	39	22	death	death	NOUN
ajst-938	39	23	.	.	PUNCT
ajst-938	40	1	while	while	SCONJ
ajst-938	40	2	radiotherapy	radiotherapy	NOUN
ajst-938	40	3	is	be	AUX
ajst-938	40	4	extensively	extensively	ADV
ajst-938	40	5	used	use	VERB
ajst-938	40	6	to	to	PART
ajst-938	40	7	treat	treat	VERB
ajst-938	40	8	localized	localized	ADJ
ajst-938	40	9	cancer	cancer	NOUN
ajst-938	40	10	,	,	PUNCT
ajst-938	40	11	improved	improve	VERB
ajst-938	40	12	understanding	understanding	NOUN
ajst-938	40	13	of	of	ADP
ajst-938	40	14	its	its	PRON
ajst-938	40	15	effects	effect	NOUN
ajst-938	40	16	on	on	ADP
ajst-938	40	17	the	the	DET
ajst-938	40	18	immune	immune	ADJ
ajst-938	40	19	system	system	NOUN
ajst-938	40	20	has	have	AUX
ajst-938	40	21	increased	increase	VERB
ajst-938	40	22	interest	interest	NOUN
ajst-938	40	23	in	in	ADP
ajst-938	40	24	its	its	PRON
ajst-938	40	25	potential	potential	ADJ
ajst-938	40	26	systemic	systemic	ADJ
ajst-938	40	27	effects	effect	NOUN
ajst-938	40	28	,	,	PUNCT
ajst-938	40	29	particularly	particularly	ADV
ajst-938	40	30	in	in	ADP
ajst-938	40	31	combination	combination	NOUN
ajst-938	40	32	with	with	ADP
ajst-938	40	33	checkpoint	checkpoint	NOUN
ajst-938	40	34	inhibitors	inhibitor	NOUN
ajst-938	40	35	such	such	ADJ
ajst-938	40	36	as	as	ADP
ajst-938	40	37	anti	anti	ADJ
ajst-938	40	38	-	-	ADJ
ajst-938	40	39	pd1	pd1	NOUN
ajst-938	40	40	.	.	PUNCT
ajst-938	41	1	the	the	DET
ajst-938	41	2	majority	majority	NOUN
ajst-938	41	3	of	of	ADP
ajst-938	41	4	patients	patient	NOUN
ajst-938	41	5	either	either	CCONJ
ajst-938	41	6	do	do	AUX
ajst-938	41	7	not	not	PART
ajst-938	41	8	respond	respond	VERB
ajst-938	41	9	or	or	CCONJ
ajst-938	41	10	develop	develop	VERB
ajst-938	41	11	resistance	resistance	NOUN
ajst-938	41	12	to	to	ADP
ajst-938	41	13	monotherapy	monotherapy	NOUN
ajst-938	41	14	over	over	ADP
ajst-938	41	15	time	time	NOUN
ajst-938	41	16	.	.	PUNCT
ajst-938	42	1	therefore	therefore	ADV
ajst-938	42	2	,	,	PUNCT
ajst-938	42	3	the	the	DET
ajst-938	42	4	efficacy	efficacy	NOUN
ajst-938	42	5	of	of	ADP
ajst-938	42	6	ox40	ox40	PROPN
ajst-938	42	7	stimulation	stimulation	NOUN
ajst-938	42	8	as	as	ADP
ajst-938	42	9	an	an	DET
ajst-938	42	10	alternative	alternative	ADJ
ajst-938	42	11	immunomodulating	immunomodulate	VERB
ajst-938	42	12	approach	approach	NOUN
ajst-938	42	13	in	in	ADP
ajst-938	42	14	combination	combination	NOUN
ajst-938	42	15	with	with	ADP
ajst-938	42	16	radiotherapy	radiotherapy	NOUN
ajst-938	42	17	is	be	AUX
ajst-938	42	18	investigated	investigate	VERB
ajst-938	42	19	.	.	PUNCT
ajst-938	43	1	the	the	DET
ajst-938	43	2	investigators	investigator	NOUN
ajst-938	43	3	hypothesize	hypothesize	VERB
ajst-938	43	4	that	that	PRON
ajst-938	43	5	sbrt	sbrt	PROPN
ajst-938	43	6	directed	direct	VERB
ajst-938	43	7	at	at	ADP
ajst-938	43	8	metastatic	metastatic	ADJ
ajst-938	43	9	breast	breast	NOUN
ajst-938	43	10	cancer	cancer	NOUN
ajst-938	43	11	lesions	lesion	NOUN
ajst-938	43	12	will	will	AUX
ajst-938	43	13	result	result	VERB
ajst-938	43	14	in	in	ADP
ajst-938	43	15	a	a	DET
ajst-938	43	16	systemic	systemic	ADJ
ajst-938	43	17	anti	anti	ADJ
ajst-938	43	18	-	-	ADJ
ajst-938	43	19	tumor	tumor	ADJ
ajst-938	43	20	immune	immune	ADJ
ajst-938	43	21	system	system	NOUN
ajst-938	43	22	response	response	NOUN
ajst-938	43	23	.	.	PUNCT
ajst-938	44	1	this	this	DET
ajst-938	44	2	amplified	amplify	VERB
ajst-938	44	3	and	and	CCONJ
ajst-938	44	4	directed	direct	VERB
ajst-938	44	5	immune	immune	ADJ
ajst-938	44	6	response	response	NOUN
ajst-938	44	7	could	could	AUX
ajst-938	44	8	result	result	VERB
ajst-938	44	9	in	in	ADP
ajst-938	44	10	antitumor	antitumor	PROPN
ajst-938	44	11	responses	response	NOUN
ajst-938	44	12	[	[	X
ajst-938	44	13	10	10	NUM
ajst-938	44	14	]	]	PUNCT
ajst-938	44	15	.	.	PUNCT
ajst-938	45	1	3.3	3.3	NUM
ajst-938	45	2	.	.	PUNCT
ajst-938	46	1	physical	physical	ADJ
ajst-938	46	2	therapy	therapy	NOUN
ajst-938	46	3	the	the	DET
ajst-938	46	4	basic	basic	ADJ
ajst-938	46	5	mechanism	mechanism	NOUN
ajst-938	46	6	of	of	ADP
ajst-938	46	7	physical	physical	ADJ
ajst-938	46	8	therapy	therapy	NOUN
ajst-938	46	9	is	be	AUX
ajst-938	46	10	to	to	PART
ajst-938	46	11	induce	induce	VERB
ajst-938	46	12	a	a	DET
ajst-938	46	13	local	local	ADJ
ajst-938	46	14	acute	acute	NOUN
ajst-938	46	15	trauma	trauma	NOUN
ajst-938	46	16	at	at	ADP
ajst-938	46	17	the	the	DET
ajst-938	46	18	tumor	tumor	NOUN
ajst-938	46	19	site	site	NOUN
ajst-938	46	20	,	,	PUNCT
ajst-938	46	21	thereby	thereby	ADV
ajst-938	46	22	inducing	induce	VERB
ajst-938	46	23	the	the	DET
ajst-938	46	24	release	release	NOUN
ajst-938	46	25	of	of	ADP
ajst-938	46	26	antigen	antigen	NOUN
ajst-938	46	27	presenting	present	VERB
ajst-938	46	28	cells	cell	NOUN
ajst-938	46	29	,	,	PUNCT
ajst-938	46	30	aim	aim	VERB
ajst-938	46	31	to	to	PART
ajst-938	46	32	initiate	initiate	VERB
ajst-938	46	33	an	an	DET
ajst-938	46	34	innate	innate	ADJ
ajst-938	46	35	immune	immune	ADJ
ajst-938	46	36	response	response	NOUN
ajst-938	46	37	targeting	target	VERB
ajst-938	46	38	both	both	DET
ajst-938	46	39	the	the	DET
ajst-938	46	40	treated	treat	VERB
ajst-938	46	41	lesion	lesion	NOUN
ajst-938	46	42	as	as	ADV
ajst-938	46	43	well	well	ADV
ajst-938	46	44	as	as	ADP
ajst-938	46	45	distinct	distinct	ADJ
ajst-938	46	46	lesions	lesion	NOUN
ajst-938	46	47	[	[	X
ajst-938	46	48	11	11	NUM
ajst-938	46	49	]	]	PUNCT
ajst-938	46	50	.	.	PUNCT
ajst-938	47	1	in	in	ADP
ajst-938	47	2	the	the	DET
ajst-938	47	3	category	category	NOUN
ajst-938	47	4	of	of	ADP
ajst-938	47	5	physical	physical	ADJ
ajst-938	47	6	therapy	therapy	NOUN
ajst-938	47	7	,	,	PUNCT
ajst-938	47	8	electrochemotherapy	electrochemotherapy	NOUN
ajst-938	47	9	is	be	AUX
ajst-938	47	10	most	most	ADV
ajst-938	47	11	frequently	frequently	ADV
ajst-938	47	12	playing	play	VERB
ajst-938	47	13	a	a	DET
ajst-938	47	14	complimentary	complimentary	ADJ
ajst-938	47	15	role	role	NOUN
ajst-938	47	16	with	with	ADP
ajst-938	47	17	immunomodulatry	immunomodulatry	NOUN
ajst-938	47	18	therapy	therapy	NOUN
ajst-938	47	19	.	.	PUNCT
ajst-938	48	1	electrochemotherapy	electrochemotherapy	NOUN
ajst-938	48	2	(	(	PUNCT
ajst-938	48	3	ect	ect	X
ajst-938	48	4	)	)	PUNCT
ajst-938	48	5	is	be	AUX
ajst-938	48	6	based	base	VERB
ajst-938	48	7	on	on	ADP
ajst-938	48	8	the	the	DET
ajst-938	48	9	local	local	ADJ
ajst-938	48	10	application	application	NOUN
ajst-938	48	11	of	of	ADP
ajst-938	48	12	electric	electric	ADJ
ajst-938	48	13	pulses	pulse	NOUN
ajst-938	48	14	to	to	PART
ajst-938	48	15	deliver	deliver	VERB
ajst-938	48	16	chemotherapeutic	chemotherapeutic	ADJ
ajst-938	48	17	drugs	drug	NOUN
ajst-938	48	18	at	at	ADP
ajst-938	48	19	the	the	DET
ajst-938	48	20	tumor	tumor	NOUN
ajst-938	48	21	site	site	NOUN
ajst-938	48	22	.	.	PUNCT
ajst-938	49	1	this	this	DET
ajst-938	49	2	reversible	reversible	ADJ
ajst-938	49	3	electroporation	electroporation	NOUN
ajst-938	49	4	enhances	enhance	VERB
ajst-938	49	5	the	the	DET
ajst-938	49	6	drug	drug	NOUN
ajst-938	49	7	uptake	uptake	ADJ
ajst-938	49	8	by	by	ADP
ajst-938	49	9	increasing	increase	VERB
ajst-938	49	10	the	the	DET
ajst-938	49	11	permeability	permeability	NOUN
ajst-938	49	12	of	of	ADP
ajst-938	49	13	the	the	DET
ajst-938	49	14	cell	cell	NOUN
ajst-938	49	15	membrane	membrane	NOUN
ajst-938	49	16	.	.	PUNCT
ajst-938	50	1	thereby	thereby	ADV
ajst-938	50	2	potentiating	potentiate	VERB
ajst-938	50	3	the	the	DET
ajst-938	50	4	cytotoxicity	cytotoxicity	NOUN
ajst-938	50	5	of	of	ADP
ajst-938	50	6	non	non	ADJ
ajst-938	50	7	-	-	ADJ
ajst-938	50	8	permeant	permeant	ADJ
ajst-938	50	9	chemotherapeutic	chemotherapeutic	ADJ
ajst-938	50	10	drugs	drug	NOUN
ajst-938	50	11	,	,	PUNCT
ajst-938	50	12	such	such	ADJ
ajst-938	50	13	as	as	ADP
ajst-938	50	14	bleomycin	bleomycin	NOUN
ajst-938	50	15	and	and	CCONJ
ajst-938	50	16	cisplatin	cisplatin	NOUN
ajst-938	50	17	[	[	X
ajst-938	50	18	12,13	12,13	NUM
ajst-938	50	19	]	]	PUNCT
ajst-938	50	20	.	.	PUNCT
ajst-938	51	1	the	the	DET
ajst-938	51	2	cytotoxicity	cytotoxicity	NOUN
ajst-938	51	3	of	of	ADP
ajst-938	51	4	ect	ect	ADJ
ajst-938	51	5	acts	act	NOUN
ajst-938	51	6	on	on	ADP
ajst-938	51	7	the	the	DET
ajst-938	51	8	whole	whole	ADJ
ajst-938	51	9	micro	micro	PROPN
ajst-938	51	10	environment	environment	NOUN
ajst-938	51	11	and	and	CCONJ
ajst-938	51	12	therefore	therefore	ADV
ajst-938	51	13	targets	target	VERB
ajst-938	51	14	directly	directly	ADV
ajst-938	51	15	the	the	DET
ajst-938	51	16	tumor	tumor	NOUN
ajst-938	51	17	cells	cell	NOUN
ajst-938	51	18	as	as	ADV
ajst-938	51	19	well	well	ADV
ajst-938	51	20	as	as	ADP
ajst-938	51	21	the	the	DET
ajst-938	51	22	interwoven	interwoven	ADJ
ajst-938	51	23	stromal	stromal	ADJ
ajst-938	51	24	and	and	CCONJ
ajst-938	51	25	endothelial	endothelial	ADJ
ajst-938	51	26	cells	cell	NOUN
ajst-938	51	27	lining	line	VERB
ajst-938	51	28	the	the	DET
ajst-938	51	29	tumor	tumor	NOUN
ajst-938	51	30	microvasculature	microvasculature	NOUN
ajst-938	51	31	.	.	PUNCT
ajst-938	52	1	the	the	DET
ajst-938	52	2	cell	cell	NOUN
ajst-938	52	3	death	death	NOUN
ajst-938	52	4	induced	induce	VERB
ajst-938	52	5	in	in	ADP
ajst-938	52	6	these	these	DET
ajst-938	52	7	endothelial	endothelial	ADJ
ajst-938	52	8	cells	cell	NOUN
ajst-938	52	9	leads	lead	VERB
ajst-938	52	10	to	to	ADP
ajst-938	52	11	the	the	DET
ajst-938	52	12	abrogation	abrogation	NOUN
ajst-938	52	13	of	of	ADP
ajst-938	52	14	tumor	tumor	NOUN
ajst-938	52	15	blood	blood	NOUN
ajst-938	52	16	flow	flow	NOUN
ajst-938	52	17	thereby	thereby	ADV
ajst-938	52	18	impairing	impair	VERB
ajst-938	52	19	the	the	DET
ajst-938	52	20	viability	viability	NOUN
ajst-938	52	21	of	of	ADP
ajst-938	52	22	tumor	tumor	NOUN
ajst-938	52	23	cells	cell	NOUN
ajst-938	52	24	surrounding	surround	VERB
ajst-938	52	25	the	the	DET
ajst-938	52	26	vessels	vessel	NOUN
ajst-938	52	27	.	.	PUNCT
ajst-938	53	1	this	this	PRON
ajst-938	53	2	results	result	VERB
ajst-938	53	3	in	in	ADP
ajst-938	53	4	a	a	DET
ajst-938	53	5	massive	massive	ADJ
ajst-938	53	6	release	release	NOUN
ajst-938	53	7	of	of	ADP
ajst-938	53	8	tumor	tumor	NOUN
ajst-938	53	9	associated	associate	VERB
ajst-938	53	10	antigens	antigen	NOUN
ajst-938	53	11	inducing	induce	VERB
ajst-938	53	12	a	a	DET
ajst-938	53	13	systemic	systemic	ADJ
ajst-938	53	14	immune	immune	ADJ
ajst-938	53	15	reaction	reaction	NOUN
ajst-938	53	16	.	.	PUNCT
ajst-938	54	1	this	this	DET
ajst-938	54	2	immune	immune	ADJ
ajst-938	54	3	response	response	NOUN
ajst-938	54	4	can	can	AUX
ajst-938	54	5	be	be	AUX
ajst-938	54	6	enhanced	enhance	VERB
ajst-938	54	7	when	when	SCONJ
ajst-938	54	8	ect	ect	X
ajst-938	54	9	is	be	AUX
ajst-938	54	10	combined	combine	VERB
ajst-938	54	11	with	with	ADP
ajst-938	54	12	other	other	ADJ
ajst-938	54	13	immunomodulatory	immunomodulatory	ADJ
ajst-938	54	14	factors	factor	NOUN
ajst-938	54	15	,	,	PUNCT
ajst-938	54	16	improving	improve	VERB
ajst-938	54	17	the	the	DET
ajst-938	54	18	antigen	antigen	ADJ
ajst-938	54	19	presentation	presentation	NOUN
ajst-938	54	20	and	and	CCONJ
ajst-938	54	21	survival	survival	NOUN
ajst-938	54	22	of	of	ADP
ajst-938	54	23	effector	effector	NOUN
ajst-938	54	24	t	t	PROPN
ajst-938	54	25	cells	cell	NOUN
ajst-938	54	26	,	,	PUNCT
ajst-938	54	27	such	such	ADJ
ajst-938	54	28	as	as	ADP
ajst-938	54	29	il-2	il-2	NOUN
ajst-938	54	30	,	,	PUNCT
ajst-938	54	31	il-12	il-12	NOUN
ajst-938	54	32	,	,	PUNCT
ajst-938	54	33	gm	gm	PROPN
ajst-938	54	34	-	-	PUNCT
ajst-938	54	35	csf	csf	PROPN
ajst-938	54	36	,	,	PUNCT
ajst-938	54	37	and	and	CCONJ
ajst-938	54	38	tnf	tnf	PROPN
ajst-938	54	39	-	-	PUNCT
ajst-938	54	40	α	α	PROPN
ajst-938	55	1	[	[	X
ajst-938	55	2	13	13	NUM
ajst-938	55	3	]	]	PUNCT
ajst-938	55	4	.	.	PUNCT
ajst-938	56	1	it	it	PRON
ajst-938	56	2	has	have	AUX
ajst-938	56	3	been	be	AUX
ajst-938	56	4	shown	show	VERB
ajst-938	56	5	that	that	SCONJ
ajst-938	56	6	frequent	frequent	ADJ
ajst-938	56	7	administration	administration	NOUN
ajst-938	56	8	of	of	ADP
ajst-938	56	9	ect	ect	PROPN
ajst-938	56	10	led	lead	VERB
ajst-938	56	11	to	to	ADP
ajst-938	56	12	an	an	DET
ajst-938	56	13	increase	increase	NOUN
ajst-938	56	14	in	in	ADP
ajst-938	56	15	the	the	DET
ajst-938	56	16	rate	rate	NOUN
ajst-938	56	17	of	of	ADP
ajst-938	56	18	complete	complete	ADJ
ajst-938	56	19	remissions	remission	NOUN
ajst-938	56	20	in	in	ADP
ajst-938	56	21	breast	breast	NOUN
ajst-938	56	22	cancer	cancer	NOUN
ajst-938	56	23	patients	patient	NOUN
ajst-938	56	24	[	[	X
ajst-938	56	25	14	14	NUM
ajst-938	56	26	]	]	PUNCT
ajst-938	56	27	.	.	PUNCT
ajst-938	57	1	4	4	X
ajst-938	57	2	.	.	X
ajst-938	57	3	conclusions	conclusion	NOUN
ajst-938	57	4	to	to	PART
ajst-938	57	5	sum	sum	VERB
ajst-938	57	6	up	up	ADP
ajst-938	57	7	,	,	PUNCT
ajst-938	57	8	in	in	ADP
ajst-938	57	9	addition	addition	NOUN
ajst-938	57	10	to	to	ADP
ajst-938	57	11	immunomodulation	immunomodulation	NOUN
ajst-938	57	12	acting	act	VERB
ajst-938	57	13	as	as	ADP
ajst-938	57	14	a	a	DET
ajst-938	57	15	mono	mono	NOUN
ajst-938	57	16	approach	approach	NOUN
ajst-938	57	17	,	,	PUNCT
ajst-938	57	18	by	by	ADP
ajst-938	57	19	combining	combine	VERB
ajst-938	57	20	oncolytic	oncolytic	ADJ
ajst-938	57	21	virotherapy	virotherapy	NOUN
ajst-938	57	22	,	,	PUNCT
ajst-938	57	23	radiotherapy	radiotherapy	NOUN
ajst-938	57	24	and	and	CCONJ
ajst-938	57	25	electrochemotherapy	electrochemotherapy	NOUN
ajst-938	57	26	with	with	ADP
ajst-938	57	27	the	the	DET
ajst-938	57	28	local	local	ADJ
ajst-938	57	29	introduction	introduction	NOUN
ajst-938	57	30	of	of	ADP
ajst-938	57	31	immunomodulatory	immunomodulatory	ADJ
ajst-938	57	32	factors	factor	NOUN
ajst-938	57	33	,	,	PUNCT
ajst-938	57	34	both	both	PRON
ajst-938	57	35	can	can	AUX
ajst-938	57	36	be	be	AUX
ajst-938	57	37	achieved	achieve	VERB
ajst-938	57	38	in	in	ADP
ajst-938	57	39	potent	potent	ADJ
ajst-938	57	40	immune	immune	ADJ
ajst-938	57	41	response	response	NOUN
ajst-938	57	42	.	.	PUNCT
ajst-938	58	1	references	reference	NOUN
ajst-938	58	2	[	[	X
ajst-938	58	3	1	1	NUM
ajst-938	58	4	]	]	PUNCT
ajst-938	58	5	siegel	siegel	PROPN
ajst-938	58	6	rl	rl	PROPN
ajst-938	58	7	,	,	PUNCT
ajst-938	58	8	miller	miller	PROPN
ajst-938	58	9	kd	kd	PROPN
ajst-938	58	10	,	,	PUNCT
ajst-938	58	11	jemal	jemal	ADJ
ajst-938	58	12	a.	a.	NOUN
ajst-938	58	13	cancer	cancer	PROPN
ajst-938	58	14	statistics	statistic	NOUN
ajst-938	58	15	,	,	PUNCT
ajst-938	58	16	2017	2017	NUM
ajst-938	58	17	.	.	PUNCT
ajst-938	59	1	ca	can	AUX
ajst-938	59	2	cancer	cancer	PROPN
ajst-938	59	3	j	j	PROPN
ajst-938	59	4	clin	clin	PROPN
ajst-938	59	5	2017	2017	NUM
ajst-938	59	6	;	;	PUNCT
ajst-938	59	7	67	67	NUM
ajst-938	59	8	:	:	PUNCT
ajst-938	59	9	7–30	7–30	NOUN
ajst-938	59	10	.	.	PUNCT
ajst-938	60	1	[	[	X
ajst-938	60	2	2	2	NUM
ajst-938	60	3	]	]	X
ajst-938	60	4	leroy	leroy	PROPN
ajst-938	60	5	,	,	PUNCT
ajst-938	60	6	p.	p.	PROPN
ajst-938	60	7	,	,	PUNCT
ajst-938	60	8	et	et	PROPN
ajst-938	60	9	al	al	PROPN
ajst-938	60	10	.	.	PROPN
ajst-938	60	11	1998	1998	NUM
ajst-938	60	12	.	.	PUNCT
ajst-938	61	1	cancer	cancer	NOUN
ajst-938	61	2	immunotherapy	immunotherapy	NOUN
ajst-938	61	3	by	by	ADP
ajst-938	61	4	direct	direct	ADJ
ajst-938	61	5	in	in	ADP
ajst-938	61	6	vivo	vivo	ADJ
ajst-938	61	7	transfer	transfer	NOUN
ajst-938	61	8	of	of	ADP
ajst-938	61	9	immunomodulatory	immunomodulatory	ADJ
ajst-938	61	10	genes	gene	NOUN
ajst-938	61	11	.	.	PUNCT
ajst-938	62	1	res	re	NOUN
ajst-938	62	2	.	.	PUNCT
ajst-938	62	3	immunol	immunol	NOUN
ajst-938	62	4	.	.	PUNCT
ajst-938	63	1	149:681	149:681	NUM
ajst-938	63	2	–	–	PUNCT
ajst-938	63	3	684	684	NUM
ajst-938	63	4	.	.	PUNCT
ajst-938	64	1	[	[	X
ajst-938	64	2	3	3	X
ajst-938	64	3	]	]	X
ajst-938	64	4	fearon	fearon	PROPN
ajst-938	64	5	,	,	PUNCT
ajst-938	64	6	e.r	e.r	PROPN
ajst-938	64	7	.	.	PROPN
ajst-938	64	8	,	,	PUNCT
ajst-938	64	9	et	et	PROPN
ajst-938	64	10	al	al	PROPN
ajst-938	64	11	.	.	PROPN
ajst-938	64	12	1990	1990	NUM
ajst-938	64	13	.	.	PUNCT
ajst-938	65	1	interleukin-2	interleukin-2	NUM
ajst-938	65	2	production	production	NOUN
ajst-938	65	3	by	by	ADP
ajst-938	65	4	tumor	tumor	NOUN
ajst-938	65	5	cells	cell	NOUN
ajst-938	65	6	bypasses	bypass	VERB
ajst-938	65	7	t	t	PROPN
ajst-938	65	8	helper	helper	NOUN
ajst-938	65	9	function	function	NOUN
ajst-938	65	10	in	in	ADP
ajst-938	65	11	the	the	DET
ajst-938	65	12	generation	generation	NOUN
ajst-938	65	13	of	of	ADP
ajst-938	65	14	an	an	DET
ajst-938	65	15	antitumor	antitumor	PROPN
ajst-938	65	16	response	response	NOUN
ajst-938	65	17	.	.	PUNCT
ajst-938	66	1	cell	cell	NOUN
ajst-938	66	2	.	.	PUNCT
ajst-938	67	1	60:397–403	60:397–403	NOUN
ajst-938	67	2	.	.	PUNCT
ajst-938	68	1	[	[	X
ajst-938	68	2	4	4	NUM
ajst-938	68	3	]	]	X
ajst-938	68	4	viret	viret	ADJ
ajst-938	68	5	,	,	PUNCT
ajst-938	68	6	c.	c.	PROPN
ajst-938	68	7	,	,	PUNCT
ajst-938	68	8	and	and	CCONJ
ajst-938	68	9	lindemann	lindemann	PROPN
ajst-938	68	10	,	,	PUNCT
ajst-938	68	11	a.	a.	PROPN
ajst-938	68	12	1997	1997	NUM
ajst-938	68	13	.	.	PUNCT
ajst-938	69	1	tumor	tumor	NOUN
ajst-938	69	2	immunotherapy	immunotherapy	NOUN
ajst-938	69	3	by	by	ADP
ajst-938	69	4	vaccination	vaccination	NOUN
ajst-938	69	5	with	with	ADP
ajst-938	69	6	cytokine	cytokine	ADJ
ajst-938	69	7	gene	gene	NOUN
ajst-938	69	8	transfected	transfecte	VERB
ajst-938	69	9	cells	cell	NOUN
ajst-938	69	10	.	.	PUNCT
ajst-938	70	1	int	int	NOUN
ajst-938	70	2	.	.	PUNCT
ajst-938	71	1	rev	rev	PROPN
ajst-938	71	2	.	.	PROPN
ajst-938	71	3	immunol	immunol	NOUN
ajst-938	71	4	.	.	PUNCT
ajst-938	72	1	14:193–212	14:193–212	NUM
ajst-938	72	2	.	.	PUNCT
ajst-938	73	1	[	[	X
ajst-938	73	2	5	5	NUM
ajst-938	73	3	]	]	X
ajst-938	73	4	golumbek	golumbek	NOUN
ajst-938	73	5	,	,	PUNCT
ajst-938	73	6	p.t	p.t	PROPN
ajst-938	73	7	.	.	PROPN
ajst-938	73	8	,	,	PUNCT
ajst-938	73	9	et	et	PROPN
ajst-938	73	10	al	al	PROPN
ajst-938	73	11	.	.	PROPN
ajst-938	73	12	1991	1991	NUM
ajst-938	73	13	.	.	PUNCT
ajst-938	74	1	treatment	treatment	NOUN
ajst-938	74	2	of	of	ADP
ajst-938	74	3	established	establish	VERB
ajst-938	74	4	renal	renal	ADJ
ajst-938	74	5	cancer	cancer	NOUN
ajst-938	74	6	by	by	ADP
ajst-938	74	7	tumor	tumor	NOUN
ajst-938	74	8	cells	cell	NOUN
ajst-938	74	9	engineered	engineer	VERB
ajst-938	74	10	to	to	PART
ajst-938	74	11	secrete	secrete	VERB
ajst-938	74	12	interleukin-4	interleukin-4	PROPN
ajst-938	74	13	.	.	PUNCT
ajst-938	75	1	science	science	NOUN
ajst-938	75	2	.	.	PUNCT
ajst-938	76	1	254:713–716	254:713–716	NOUN
ajst-938	76	2	.	.	PUNCT
ajst-938	77	1	[	[	X
ajst-938	77	2	6	6	X
ajst-938	77	3	]	]	X
ajst-938	77	4	maroun	maroun	PROPN
ajst-938	77	5	j	j	PROPN
ajst-938	77	6	,	,	PUNCT
ajst-938	77	7	munoz	munoz	PROPN
ajst-938	77	8	-	-	PUNCT
ajst-938	77	9	alia	alia	PROPN
ajst-938	77	10	m	m	PROPN
ajst-938	77	11	,	,	PUNCT
ajst-938	77	12	ammayappan	ammayappan	VERB
ajst-938	77	13	a	a	PRON
ajst-938	77	14	,	,	PUNCT
ajst-938	77	15	schulze	schulze	NOUN
ajst-938	77	16	a	a	X
ajst-938	77	17	,	,	PUNCT
ajst-938	77	18	peng	peng	PROPN
ajst-938	77	19	kw	kw	PROPN
ajst-938	77	20	,	,	PUNCT
ajst-938	77	21	russell	russell	PROPN
ajst-938	77	22	s.	s.	PROPN
ajst-938	77	23	designing	designing	PROPN
ajst-938	77	24	and	and	CCONJ
ajst-938	77	25	building	building	NOUN
ajst-938	77	26	oncolytic	oncolytic	ADJ
ajst-938	77	27	viruses	virus	NOUN
ajst-938	77	28	.	.	PUNCT
ajst-938	78	1	future	future	ADJ
ajst-938	78	2	virol	virol	NOUN
ajst-938	78	3	.	.	PUNCT
ajst-938	79	1	(	(	PUNCT
ajst-938	79	2	2017	2017	NUM
ajst-938	79	3	)	)	PUNCT
ajst-938	79	4	12:193–213	12:193–213	PROPN
ajst-938	79	5	.	.	PUNCT
ajst-938	80	1	doi	doi	NOUN
ajst-938	80	2	:	:	PUNCT
ajst-938	80	3	10.2217	10.2217	NUM
ajst-938	80	4	/	/	SYM
ajst-938	80	5	fvl-2016	fvl-2016	NOUN
ajst-938	80	6	-	-	PUNCT
ajst-938	80	7	0129	0129	NUM
ajst-938	81	1	[	[	X
ajst-938	81	2	7	7	X
ajst-938	81	3	]	]	X
ajst-938	81	4	poh	poh	PROPN
ajst-938	81	5	a.	a.	PROPN
ajst-938	81	6	first	first	PROPN
ajst-938	81	7	oncolytic	oncolytic	ADJ
ajst-938	81	8	viral	viral	ADJ
ajst-938	81	9	therapy	therapy	NOUN
ajst-938	81	10	for	for	ADP
ajst-938	81	11	melanoma	melanoma	NOUN
ajst-938	81	12	.	.	PUNCT
ajst-938	82	1	cancer	cancer	NOUN
ajst-938	82	2	discov	discov	NOUN
ajst-938	82	3	.	.	PUNCT
ajst-938	83	1	(	(	PUNCT
ajst-938	83	2	2016	2016	NUM
ajst-938	83	3	)	)	PUNCT
ajst-938	83	4	6:6	6:6	NUM
ajst-938	83	5	.	.	PUNCT
ajst-938	83	6	doi	doi	NOUN
ajst-938	83	7	:	:	PUNCT
ajst-938	83	8	10.1158/2159	10.1158/2159	NUM
ajst-938	83	9	-	-	PUNCT
ajst-938	83	10	8290.cd	8290.cd	NUM
ajst-938	83	11	-	-	PUNCT
ajst-938	83	12	nb2015	nb2015	PROPN
ajst-938	83	13	-	-	PUNCT
ajst-938	83	14	158	158	NUM
ajst-938	84	1	[	[	X
ajst-938	84	2	8	8	NUM
ajst-938	84	3	]	]	X
ajst-938	84	4	parato	parato	PROPN
ajst-938	84	5	ka	ka	PROPN
ajst-938	84	6	,	,	PUNCT
ajst-938	84	7	breitbach	breitbach	PROPN
ajst-938	84	8	cj	cj	NOUN
ajst-938	84	9	,	,	PUNCT
ajst-938	84	10	le	le	X
ajst-938	84	11	boeuf	boeuf	PROPN
ajst-938	84	12	f	f	PROPN
ajst-938	84	13	,	,	PUNCT
ajst-938	84	14	wang	wang	PROPN
ajst-938	84	15	j	j	PROPN
ajst-938	84	16	,	,	PUNCT
ajst-938	84	17	storbeck	storbeck	PROPN
ajst-938	84	18	c	c	AUX
ajst-938	84	19	,	,	PUNCT
ajst-938	84	20	ilkow	ilkow	VERB
ajst-938	84	21	c	c	NOUN
ajst-938	84	22	,	,	PUNCT
ajst-938	84	23	et	et	PROPN
ajst-938	84	24	al	al	PROPN
ajst-938	84	25	.	.	PUNCT
ajst-938	85	1	the	the	DET
ajst-938	85	2	oncolytic	oncolytic	ADJ
ajst-938	85	3	poxvirus	poxvirus	ADJ
ajst-938	85	4	jx-594	jx-594	NOUN
ajst-938	85	5	selectively	selectively	ADV
ajst-938	85	6	replicates	replicate	VERB
ajst-938	85	7	in	in	ADP
ajst-938	85	8	and	and	CCONJ
ajst-938	85	9	destroys	destroy	VERB
ajst-938	85	10	cancer	cancer	NOUN
ajst-938	85	11	cells	cell	NOUN
ajst-938	85	12	driven	drive	VERB
ajst-938	85	13	by	by	ADP
ajst-938	85	14	genetic	genetic	ADJ
ajst-938	85	15	pathways	pathway	NOUN
ajst-938	85	16	commonly	commonly	ADV
ajst-938	85	17	activated	activate	VERB
ajst-938	85	18	in	in	ADP
ajst-938	85	19	cancers	cancer	NOUN
ajst-938	85	20	.	.	PUNCT
ajst-938	86	1	mol	mol	ADP
ajst-938	86	2	ther	ther	ADV
ajst-938	86	3	.	.	PUNCT
ajst-938	87	1	(	(	PUNCT
ajst-938	87	2	2012	2012	NUM
ajst-938	87	3	)	)	PUNCT
ajst-938	87	4	20:749–58	20:749–58	PROPN
ajst-938	87	5	.	.	PUNCT
ajst-938	88	1	doi	doi	NOUN
ajst-938	88	2	:	:	PUNCT
ajst-938	88	3	10.1038	10.1038	NUM
ajst-938	88	4	/	/	SYM
ajst-938	88	5	mt.2011.276	mt.2011.276	NOUN
ajst-938	89	1	[	[	X
ajst-938	89	2	9	9	NUM
ajst-938	89	3	]	]	X
ajst-938	89	4	jaffray	jaffray	X
ajst-938	89	5	da	da	PROPN
ajst-938	89	6	.	.	PUNCT
ajst-938	89	7	image	image	NOUN
ajst-938	89	8	-	-	PUNCT
ajst-938	89	9	guided	guide	VERB
ajst-938	89	10	radiotherapy	radiotherapy	NOUN
ajst-938	89	11	:	:	PUNCT
ajst-938	89	12	from	from	ADP
ajst-938	89	13	current	current	ADJ
ajst-938	89	14	concept	concept	NOUN
ajst-938	89	15	to	to	ADP
ajst-938	89	16	future	future	ADJ
ajst-938	89	17	perspectives	perspective	NOUN
ajst-938	89	18	.	.	PUNCT
ajst-938	90	1	nat	nat	PROPN
ajst-938	90	2	rev	rev	VERB
ajst-938	90	3	clin	clin	PROPN
ajst-938	90	4	oncol	oncol	PROPN
ajst-938	90	5	.	.	PUNCT
ajst-938	91	1	(	(	PUNCT
ajst-938	91	2	2012	2012	NUM
ajst-938	91	3	)	)	PUNCT
ajst-938	92	1	9:688–99	9:688–99	PROPN
ajst-938	92	2	.	.	PUNCT
ajst-938	92	3	doi	doi	NOUN
ajst-938	92	4	:	:	PUNCT
ajst-938	92	5	10.1038	10.1038	NUM
ajst-938	92	6	/	/	SYM
ajst-938	92	7	nrclinonc.2012.194	nrclinonc.2012.194	PROPN
ajst-938	93	1	[	[	X
ajst-938	93	2	10	10	NUM
ajst-938	93	3	]	]	PUNCT
ajst-938	93	4	nct01642290	nct01642290	NOUN
ajst-938	94	1	[	[	X
ajst-938	94	2	11	11	NUM
ajst-938	94	3	]	]	PUNCT
ajst-938	94	4	locy	locy	PROPN
ajst-938	94	5	h	h	PROPN
ajst-938	94	6	,	,	PUNCT
ajst-938	94	7	de	de	PROPN
ajst-938	94	8	mey	mey	PROPN
ajst-938	94	9	s	s	PROPN
ajst-938	94	10	,	,	PUNCT
ajst-938	94	11	de	de	PROPN
ajst-938	94	12	mey	mey	PROPN
ajst-938	94	13	w	w	PROPN
ajst-938	94	14	,	,	PUNCT
ajst-938	94	15	de	de	PROPN
ajst-938	94	16	ridder	ridder	PROPN
ajst-938	94	17	m	m	PROPN
ajst-938	94	18	,	,	PUNCT
ajst-938	94	19	thielemans	thielemans	PROPN
ajst-938	94	20	k	k	PROPN
ajst-938	94	21	,	,	PUNCT
ajst-938	94	22	maenhout	maenhout	ADP
ajst-938	94	23	sk	sk	PROPN
ajst-938	94	24	.	.	PROPN
ajst-938	94	25	immunomodulation	immunomodulation	NOUN
ajst-938	94	26	of	of	ADP
ajst-938	94	27	the	the	DET
ajst-938	94	28	tumor	tumor	NOUN
ajst-938	94	29	microenvironment	microenvironment	NOUN
ajst-938	94	30	:	:	PUNCT
ajst-938	94	31	turn	turn	VERB
ajst-938	94	32	foe	foe	NOUN
ajst-938	94	33	into	into	ADP
ajst-938	94	34	friend	friend	NOUN
ajst-938	94	35	.	.	PUNCT
ajst-938	95	1	front	front	ADJ
ajst-938	95	2	immunol	immunol	NOUN
ajst-938	95	3	.	.	PUNCT
ajst-938	96	1	2018	2018	NUM
ajst-938	96	2	dec	dec	PROPN
ajst-938	96	3	11;9:2909	11;9:2909	PROPN
ajst-938	96	4	.	.	PUNCT
ajst-938	97	1	doi	doi	NOUN
ajst-938	97	2	:	:	PUNCT
ajst-938	97	3	10.3389	10.3389	NUM
ajst-938	97	4	/	/	SYM
ajst-938	97	5	fimmu.2018.02909	fimmu.2018.02909	PROPN
ajst-938	97	6	.	.	PUNCT
ajst-938	98	1	pmid	pmid	NOUN
ajst-938	98	2	:	:	PUNCT
ajst-938	98	3	30619273	30619273	NUM
ajst-938	98	4	;	;	PUNCT
ajst-938	98	5	pmcid	pmcid	NOUN
ajst-938	98	6	:	:	PUNCT
ajst-938	98	7	pmc6297829	pmc6297829	ADV
ajst-938	98	8	.	.	PUNCT
ajst-938	99	1	[	[	X
ajst-938	99	2	12	12	NUM
ajst-938	99	3	]	]	X
ajst-938	99	4	sersa	sersa	NOUN
ajst-938	99	5	g	g	PROPN
ajst-938	99	6	,	,	PUNCT
ajst-938	99	7	miklavcic	miklavcic	VERB
ajst-938	99	8	d.	d.	PROPN
ajst-938	99	9	electrochemotherapy	electrochemotherapy	PROPN
ajst-938	99	10	of	of	ADP
ajst-938	99	11	tumours	tumours	PROPN
ajst-938	99	12	.	.	PUNCT
ajst-938	100	1	j	j	PROPN
ajst-938	100	2	vis	vis	X
ajst-938	100	3	exp	exp	PROPN
ajst-938	100	4	.	.	PUNCT
ajst-938	100	5	(	(	PUNCT
ajst-938	100	6	2008	2008	NUM
ajst-938	100	7	)	)	PUNCT
ajst-938	100	8	22:1038	22:1038	X
ajst-938	100	9	.	.	PUNCT
ajst-938	101	1	doi	doi	NOUN
ajst-938	101	2	:	:	PUNCT
ajst-938	102	1	10.3791/1038	10.3791/1038	NUM
ajst-938	102	2	[	[	X
ajst-938	102	3	13	13	NUM
ajst-938	102	4	]	]	X
ajst-938	102	5	sersa	sersa	NOUN
ajst-938	102	6	g	g	PROPN
ajst-938	102	7	,	,	PUNCT
ajst-938	102	8	miklavcic	miklavcic	NOUN
ajst-938	102	9	d	d	NOUN
ajst-938	102	10	,	,	PUNCT
ajst-938	102	11	cemazar	cemazar	NOUN
ajst-938	102	12	m	m	PROPN
ajst-938	102	13	,	,	PUNCT
ajst-938	102	14	rudolf	rudolf	PROPN
ajst-938	102	15	z	z	PROPN
ajst-938	102	16	,	,	PUNCT
ajst-938	102	17	pucihar	pucihar	ADJ
ajst-938	102	18	g	g	NOUN
ajst-938	102	19	,	,	PUNCT
ajst-938	102	20	snoj	snoj	VERB
ajst-938	102	21	m.	m.	NOUN
ajst-938	102	22	electrochemotherapy	electrochemotherapy	NOUN
ajst-938	102	23	in	in	ADP
ajst-938	102	24	treatment	treatment	NOUN
ajst-938	102	25	of	of	ADP
ajst-938	102	26	tumours	tumour	NOUN
ajst-938	102	27	.	.	PUNCT
ajst-938	103	1	eur	eur	PROPN
ajst-938	103	2	j	j	PROPN
ajst-938	103	3	surg	surg	PROPN
ajst-938	103	4	.	.	PUNCT
ajst-938	104	1	(	(	PUNCT
ajst-938	104	2	2007	2007	NUM
ajst-938	104	3	)	)	PUNCT
ajst-938	104	4	34:232–43	34:232–43	NOUN
ajst-938	104	5	.	.	PUNCT
ajst-938	105	1	doi	doi	NOUN
ajst-938	105	2	:	:	PUNCT
ajst-938	105	3	10.1016	10.1016	NUM
ajst-938	105	4	/	/	SYM
ajst-938	105	5	j.ejso.2007.05.016	j.ejso.2007.05.016	PROPN
ajst-938	106	1	[	[	X
ajst-938	106	2	14	14	NUM
ajst-938	106	3	]	]	PUNCT
ajst-938	106	4	schmidt	schmidt	PROPN
ajst-938	106	5	g	g	PROPN
ajst-938	106	6	,	,	PUNCT
ajst-938	106	7	juhasz	juhasz	NOUN
ajst-938	106	8	-	-	PUNCT
ajst-938	106	9	boss	boss	NOUN
ajst-938	106	10	i	i	NOUN
ajst-938	106	11	,	,	PUNCT
ajst-938	106	12	solomayer	solomayer	NOUN
ajst-938	106	13	e	e	PROPN
ajst-938	106	14	-	-	PROPN
ajst-938	106	15	f	f	PROPN
ajst-938	106	16	,	,	PUNCT
ajst-938	106	17	herr	herr	PROPN
ajst-938	106	18	d.	d.	PROPN
ajst-938	106	19	electrochemotherapy	electrochemotherapy	PROPN
ajst-938	106	20	in	in	ADP
ajst-938	106	21	breast	breast	NOUN
ajst-938	106	22	cancer	cancer	NOUN
ajst-938	106	23	:	:	PUNCT
ajst-938	106	24	a	a	DET
ajst-938	106	25	review	review	NOUN
ajst-938	106	26	of	of	ADP
ajst-938	106	27	references	reference	NOUN
ajst-938	106	28	.	.	PUNCT
ajst-938	107	1	geburtshilfe	geburtshilfe	VERB
ajst-938	107	2	frauenheilkd	frauenheilkd	NOUN
ajst-938	107	3	(	(	PUNCT
ajst-938	107	4	2014	2014	NUM
ajst-938	107	5	)	)	PUNCT
ajst-938	107	6	74:557–62	74:557–62	NOUN
ajst-938	107	7	.	.	PUNCT
ajst-938	108	1	doi	doi	NOUN
ajst-938	108	2	:	:	PUNCT
ajst-938	108	3	10.1055	10.1055	NUM
ajst-938	108	4	/	/	SYM
ajst-938	108	5	s0034	s0034	NOUN
ajst-938	108	6	-	-	PUNCT
ajst-938	108	7	1368538	1368538	NUM