# bib

id: cord-278142-xnkqg4ef
author: Lin, Fang
title: Cobrotoxin could be an effective therapeutic for COVID-19
date: 2020-08-25
extension: .txt
mime: text/plain
words: 1972
sentence: 85
flesch: 37
cache: cache/cord-278142-xnkqg4ef.txt
txt: txt/cord-278142-xnkqg4ef.txt
summary:
  Anti-inflammatory activity: NNAV and α-neurotoxins have strong inhibitory effects on inflammation; thus, they could inhibit the cytokine storm caused by SARS-COV2 infection. Clinical features of patients infected with 2019 novel coronavirus in Wuhan The structural loop II of cobrotoxin is the main binding region for nAChR and epitope in the region is conformation-dependent Cobrotoxin extracted from Naja atra venom relieves arthritis symptoms through anti-inflammation and immunosuppression effects in rat arthritis model Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin Cobrotoxin inhibits NFkappa B activation and target gene expression through reaction with NF-kappa B signal molecules Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress Differential effects of Naja naja atra venom on immune activity Rabies virus infection of IMR-32 human neuroblastoma cells and effect of neurochemical and other agents Peptide derived from cobra venom inhibits HIV infection Modulation of type I interferon system by African swine fever virus Snake venom preparation for drug-resistant human immunodeficiency virus Inhibition of herpes simplex virus replication by cobra alpha-neurotoxoid Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Pathological findings of COVID-19 associated with acute respiratory distress syndrome Clinical and immunological features of severe and moderate coronavirus disease 2019 Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Deep vein thrombosis in hospitalized patients with coronavirus disease 2019 (COVID-19) in Wuhan, China: prevalence, risk factors, and outcome Increased expression of CD8 marker on T-cells in COVID-19 patients A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy A long-form alphaneurotoxin from cobra venom produces potent opioid-independent analgesia Conflict of interest: All authors declare no conflict interest.


id: cord-002006-pwlybr2h
author: Liu, Yuan-yuan
date: 2016-03-14
extension: .txt
mime: text/plain
words: 3924
sentence: 159
flesch: 45
cache: cache/cord-002006-pwlybr2h.txt
txt: txt/cord-002006-pwlybr2h.txt
title:
  Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo

summary:
  At 24 h after transfection, the cells were infected with 100 TCID 50 HTNV 76-118 (100 μL per well), and viral RNA was detected by qRT-PCR at 24 or 48 hour post-infection (hpi) to determine the interference efficiency. DMEM containing 2% FBS was used to maintain the medium after viral infection.


id: cord-012796-wfdt07vs
author: Zhang, Sai-long
date: 2020-01-16
extension: .txt
mime: text/plain
words: 4028
sentence: 174
flesch: 46
cache: cache/cord-012796-wfdt07vs.txt
txt: txt/cord-012796-wfdt07vs.txt
title:
  Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells

summary:
  The breeding strategy for Metrnl −/− mice was described elsewhere [17] . Beclin-1 and LC3-II/I expression levels decreased and p62 expression levels increased in Metrnl −/− mice induced by 3% DSS (Fig. 5a) .


id: cord-012791-dyk5mr1q
author: Zheng, Yong
date: 2019-09-25
extension: .txt
mime: text/plain
words: 4165
sentence: 149
flesch: 39
cache: cache/cord-012791-dyk5mr1q.txt
txt: txt/cord-012791-dyk5mr1q.txt
title:
  Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway

summary:
  However, ICS II abolished these changes, suggesting that ICS II exerts potent antiinflammatory effects, at least partly through modulating the IKK/IκB/NF-κB pathway. Primary rat astrocytes were pretreated with ICS II (5, 10, and 20 μM) or dexamethasone (DXMS, 1 μM) for 1 h, thereafter, treated with LPS for another 24 h. We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in the astrocytes.


id: cord-012716-t19zmvm6
author: Guo, Chen-hong
date: 2020-02-28
extension: .txt
mime: text/plain
words: 5114
sentence: 230
flesch: 44
cache: cache/cord-012716-t19zmvm6.txt
txt: txt/cord-012716-t19zmvm6.txt
title:
  Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin

summary:
  The above results revealed that Dicer knockout can cause progressive neuroinflammation in the SN, which is one of the hallmarks of pathology in PD. Acute application of L-DOPA to Dicer cKO mice relieved PD-like motor impairments We characterized the PD-like behavioral and pathological phenotypes in inducible Dicer cKO mice. In this study, we established an inducible DA neuron-specific Dicer cKO mouse line by crossing floxed Dicer mice (Dicer f/f ) with DAT-icreER mice to obtain DAT-icreER;Dicer f/+ mice, the latter were bred with Dicer f/f mice to produce DAT-icreER;Dicer f/f mice, which we called Dicer cKO mice.


id: cord-012747-s4wf0pix
author: Prehn, Jochen H M
title: Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration
date: 2020-03-06
extension: .txt
mime: text/plain
words: 3479
sentence: 144
flesch: 32
cache: cache/cord-012747-s4wf0pix.txt
txt: txt/cord-012747-s4wf0pix.txt
summary:
  Delivery of angiogenin protein reduces neurodegeneration and delays disease progression in in vitro and in vivo models of ALS and in vitro models of PD. Many of the reported PD ANG variants were predicted to impair angiogenin protein function [38] .


id: cord-013544-x3eyimug
author: Hu, Yue-huai
date: 2020-04-01
extension: .txt
mime: text/plain
words: 4111
sentence: 207
flesch: 50
cache: cache/cord-013544-x3eyimug.txt
txt: txt/cord-013544-x3eyimug.txt
title:
  sFRP1 protects H9c2 cardiac myoblasts from doxorubicin-induced apoptosis by inhibiting the Wnt/PCP-JNK pathway

summary:
  A flow cytometer was used to evaluate the extent of H9c2 cell apoptosis, and the results implied that Dox treatment increased both early and late apoptosis in the cells (Fig. 1f ). The extent of cell apoptosis was assessed with an annexin V/propidium iodide (PI) apoptosis assay kit (BestBio, Shanghai, China).


id: cord-012823-i3yhaagz
author: Zhang, Zhi-hao
date: 2019-11-08
extension: .txt
mime: text/plain
words: 4955
sentence: 208
flesch: 51
cache: cache/cord-012823-i3yhaagz.txt
txt: txt/cord-012823-i3yhaagz.txt
title:
  Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ

summary:
  Treatment with AA group significantly attenuated the increase in BUN and Scr levels. PCA and OPLS-DA score plots of plasma metabolites in the control, UUO and UUO + AA groups are shown in Fig.


id: cord-012726-1i1mj3jw
author: Chen, Xue-han
title: Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis
date: 2019-06-13
extension: .txt
mime: text/plain
words: 4985
sentence: 214
flesch: 47
cache: cache/cord-012726-1i1mj3jw.txt
txt: txt/cord-012726-1i1mj3jw.txt
summary:
  Because the USP5/c-Maf axis plays a critical role in promoting MM cell proliferation and survival, and interference with USP5 and c-Maf leads to MM cell apoptosis [8] , we next evaluated the effects of mebendazole on MM cell survival and apoptosis. Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model Brain penetration and efficacy of different mebendazole polymorphs in a mouse brain tumor model Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo Predicting new indications for approved drugs using a proteochemometric method Repurposing the antihelmintic mebendazole as a hedgehog inhibitor Comprehensive modeling and discovery of mebendazole as a novel TRAF2-and NCK-interacting kinase inhibitor C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor This work was partly supported by the National Natural Science Foundation of China (81320108023 to XM, 81600171 to ZZ, and 81770215 to BC), the Natural Science Foundation of Jiangsu Higher Education Institutes of China (17KJA180010 to XM),


id: cord-001268-sc0ersky
author: Zhang, Wei-ying
title: Gene expression profiles of human liver cells mediated by hepatitis B virus X protein
date: 2009-04-03
extension: .txt
mime: text/plain
words: 4569
sentence: 210
flesch: 45
cache: cache/cord-001268-sc0ersky.txt
txt: txt/cord-001268-sc0ersky.txt
summary:
  Adhesion of tumor cells to host cell layers and subsequent migration are pivotal steps in cancer invasion and metastasis. key: cord-001268-sc0ersky authors: Zhang, Wei-ying; Xu, Fu-qing; Shan, Chang-liang; Xiang, Rong; Ye, Li-hong; Zhang, Xiao-dong title: Gene expression profiles of human liver cells mediated by hepatitis B virus X protein date: 2009-04-03 journal: Acta Pharmacol Sin DOI: 10.1038/aps.2009.22 sha: doc_id: 1268 cord_uid: sc0ersky AIM: To demonstrate the gene expression profiles mediated by hepatitis B virus X protein (HBx), we characterized the molecular features of pathogenesis associated with HBx in a human liver cell model.


id: cord-012781-e4js9qrs
author: Sun, Qingxue
title: Cancer nanomedicine meets immunotherapy: opportunities and challenges
date: 2020-06-17
extension: .txt
mime: text/plain
words: 3217
sentence: 140
flesch: 30
cache: cache/cord-012781-e4js9qrs.txt
txt: txt/cord-012781-e4js9qrs.txt
summary:
  key: cord-012781-e4js9qrs authors: Sun, Qingxue; Bai, Xiangyang; Sofias, Alexandros Marios; van der Meel, Roy; Ruiz-Hernandez, Eduardo; Storm, Gert; Hennink, Wim E.; De Geest, Bruno; Kiessling, Fabian; Yu, Hai-jun; Lammers, Twan; Shi, Yang title: Cancer nanomedicine meets immunotherapy: opportunities and challenges date: 2020-06-17 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-020-0448-9 sha: doc_id: 12781 cord_uid: e4js9qrs Cancer nanomedicines have shown promise in combination immunotherapy, thus far mostly preclinically but also already in clinical trials. The interplay between cancer nanomedicine and immunotherapy has been demonstrated in multiple preclinical studies [14] .


id: cord-012784-c74jr4ga
author: Zhang, Le-le
title: Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity
date: 2020-02-11
extension: .txt
mime: text/plain
words: 4894
sentence: 220
flesch: 44
cache: cache/cord-012784-c74jr4ga.txt
txt: txt/cord-012784-c74jr4ga.txt
summary:
  NLE treatment inhibited the proliferation of lung cancer cells via G2 phase cell cycle arrest mediated by the downregulation of Cyclin B1 [6] . Compared with the body weights of mice in the control group, NLE treatment did not have an obvious effect on mouse body weight (Fig. 1c) .


id: cord-012828-wsjob1p8
author: Wang, Yan-hang
date: 2019-09-10
extension: .txt
mime: text/plain
words: 4234
sentence: 191
flesch: 36
cache: cache/cord-012828-wsjob1p8.txt
txt: txt/cord-012828-wsjob1p8.txt
title:
  Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway

summary:
  Recently, dopamine receptors have been found to be involved in multiple immunopathological processes and considered as valuable therapeutic targets for inflammation-associated neurologic diseases. By using transcriptomics coupled with bioinformatics analysis, we revealed that isosibiricin treatment mainly affect dopamine receptor signalling pathway.


id: cord-012837-fuwp08qt
author: Lu, Chen-chen
date: 2020-03-17
extension: .txt
mime: text/plain
words: 4956
sentence: 203
flesch: 40
cache: cache/cord-012837-fuwp08qt.txt
txt: txt/cord-012837-fuwp08qt.txt
title:
  Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy

summary:
  Oxidative stress in diabetic nephropathy with early chronic kidney disease Role of the intrarenal renin-angiotensin system in the progression of renal disease Signals from the gut microbiota to distant organs in physiology and disease Unraveling the environmental and genetic interactions in atherosclerosis: central role of the gut microbiota Microbiota and diabetes: an evolving relationship A metagenome-wide association study of gut microbiota in type 2 diabetes Gut metagenome in European women with normal, impaired and diabetic glucose control Diversity of human colonic butyrateproducing bacteria revealed by analysis of the butyryl-CoA:acetate CoAtransferase gene Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome Gut microbiota in human adults with type 2 diabetes differs from nondiabetic adults Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study Toward defining the autoimmune microbiome for type 1 diabetes Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia The neuropharmacology of butyrate: The bread and butter of the microbiota-gutbrain axis? Regulation of inflammation by short chain fatty acids Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation Immunocytochemical localization of Na+ channels in rat kidney medulla Plasma and renal renin concentrations in adult sheep after prenatal betamethasone exposure Progression of renal disease and renal hypertrophy Changes in gut microbiota in the three groups The results of 16S rDNA gene sequencing showed that there were significant differences in the bacterial composition and abundance of gut microbiota between the control and DM groups.


id: cord-012722-ewc2awv1
author: Bian, Yu
date: 2019-10-23
extension: .txt
mime: text/plain
words: 4858
sentence: 204
flesch: 41
cache: cache/cord-012722-ewc2awv1.txt
txt: txt/cord-012722-ewc2awv1.txt
title:
  Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis

summary:
  key: cord-012722-ewc2awv1 authors: Bian, Yu; Li, Xin; Pang, Ping; Hu, Xue-ling; Yu, Shu-ting; Liu, Yi-ning; Li, Xin; Wang, Ning; Wang, Jin-hui; Xiao, Wei; Du, Wei-jie; Yang, Bao-feng title: Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis date: 2019-10-23 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-019-0307-8 sha: doc_id: 12722 cord_uid: ewc2awv1 Pyroptosis is a form of inflammatory cell death that could be driven by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation following myocardial infarction (MI). Pyroptosis is a newly identified form of inflammatory cell death triggered by caspase-1, and it has been reported to be casually linked to a variety of diseases, particularly to cardiomyocyte loss following MI and ischemia/reperfusion [9, 30, 31] .


id: cord-012769-clbqckj2
author: Yan, You-you
date: 2020-02-11
extension: .txt
mime: text/plain
words: 3766
sentence: 166
flesch: 38
cache: cache/cord-012769-clbqckj2.txt
txt: txt/cord-012769-clbqckj2.txt
title:
  A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells

summary:
  Pancreatic cancer genomes: implications for clinical management and therapeutic development Pancreatic cancer chemoresistance to gemcitabine Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to Navitoclax Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models Structure-guided design of pyridoclax derivatives based on Noxa/Mcl-1 interaction mode Mcl-1 phosphorylation without degradation mediates sensitivity to HDAC inhibitors by liberating BH3-only proteins Therapeutic developments in pancreatic cancer: current and future perspectives New iridoids from the roots of Valeriana dioscoridis Sm Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells Anti-invasion and antimetastasis effects of Valjatrate E via reduction of matrix metalloproteinases expression and suppression of MAPK/ERK signaling pathway Jatamanvaltrate P induces cell cycle arrest, apoptosis and autophagy in human breast cancer cells in vitro and in vivo Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine PUMA and BIM are required for oncogene inactivation-induced apoptosis Found in translation: How preclinical research is guiding the clinical development of the BCL2-selective inhibitor Venetoclax Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells Chemical constituents from Valeriana polystachya Smith and evaluation of their effects on the acetylcholinesterase and prolyl oligopeptidase activities Valepotriates from the roots and rhizomes of Valeriana jatamansi Jones as novel N-type calcium channel antagonists Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway Hydrogen sulfide donating ent-kaurane and spirolactone-type 6,7-seco-ent-kaurane derivatives: design, synthesis and antiproliferative properties l-Serine protects mouse hippocampal neuronal HT22cells against oxidative stress-mediated mitochondrial damage and apoptotic cell death Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9 The novel microRNA hsa-miR-CHA1 regulates cell proliferation and apoptosis in human lung cancer by targeting XIAP LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression Low-molecular-mass hyaluronan induces pulmonary inflammation by up-regulation of Mcl-1 to inhibit neutrophil apoptosis via PI3K/ Akt1 pathway BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199 Targeted inhibition of PI3Kalpha/delta is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1 Conflict of interest: The authors declare no conflicts of interest. Herein, we obtained a series of valepotriate derivatives and aimed to explore candidate compounds with potent anticancer activity against pancreatic cancer cells.


id: cord-012767-h5gv9g62
author: Wei, Xiao-min
date: 2020-03-09
extension: .txt
mime: text/plain
words: 4332
sentence: 196
flesch: 45
cache: cache/cord-012767-h5gv9g62.txt
txt: txt/cord-012767-h5gv9g62.txt
title:
  Protein tyrosine phosphatase L1 represses endothelial-mesenchymal transition by inhibiting IL-1β/NF-κB/Snail signaling

summary:
  However, the regulatory role and underlying molecular mechanisms of PTPL1 in PH, a disorder attributed necessarily to EnMT of vascular endothelial cells, are not clearly elucidated. Therefore, PTPL1 may attenuate NF-κB signaling by dephosphorylating IκBα and increasing its half-life in vascular endothelial cells.


id: cord-012753-cu6qcen9
author: Qi, Fei-long
date: 2020-05-28
extension: .txt
mime: text/plain
words: 3787
sentence: 157
flesch: 25
cache: cache/cord-012753-cu6qcen9.txt
txt: txt/cord-012753-cu6qcen9.txt
title:
  Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells

summary:
  [9] ; (2) tumor antigens that are heterogeneous and have high mutation rates make surrounding immune cells unable to recognize and kill tumor cells [10] ; and (3) tumor cells have low immunogenicity and are not easily recognized by antigenpresenting cells (APCs) Therefore, the intrinsic immune system cannot clear tumor cells in the same manner that it eliminates ordinary foreign substances.


id: cord-338901-1kzy7rts
author: Li, Heng
title: Overview of therapeutic drug research for COVID-19 in China
date: 2020-06-17
extension: .txt
mime: text/plain
words: 5106
sentence: 212
flesch: 44
cache: cache/cord-338901-1kzy7rts.txt
txt: txt/cord-338901-1kzy7rts.txt
summary:
  Molecular basis of ribavirin resistance Comparative effectiveness of aerosolized versus oral ribavirin for the treatment of respiratory syncytial virus infections: a single-center retrospective cohort study and review of the literature Ideal oral combinations to eradicate HCV: the role of ribavirin A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS) Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak Ribavirin and interferonbeta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Use of chloroquine in viral diseases Effects of chloroquine on viral infections: an old drug against today's diseases? Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Evidence for a common evolutionary origin of coronavirus spike protein receptor-binding subunits Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Progress in antiviral therapy of new coronavirus pneumonia Arbidol as a broad-spectrum antiviral: an update Arbidol: a broad-spectrum antiviral compound that blocks viral fusion The synthetic antiviral drug arbidol inhibits globally prevalent pathogenic viruses Comparison of inhibitory effects of arbidol and Lianhuaqingwen Capsules on Middle East respiratory syndrome coronavirus in vitro and in vivo Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment Dancing with chemical formulae of antivirals: a personal account Dancing with chemical formulae of antivirals: A panoramic view (Part 2) Mechanism of action of T-705 against influenza virus. In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Structural basis of receptor recognition by SARS-CoV-2 Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV Nucleotide analogues as inhibitors of viral polymerases SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor


id: cord-012840-tgcrg5db
author: Liu, Hao-chen
date: 2020-01-13
extension: .txt
mime: text/plain
words: 5666
sentence: 306
flesch: 51
cache: cache/cord-012840-tgcrg5db.txt
txt: txt/cord-012840-tgcrg5db.txt
title:
  PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats

summary:
  PKPD modeling of predictors for adverse effects and overall survival in sunitinib-treated patients with GIST Cardiovascular and renal toxicity during angiogenesis inhibition: clinical and mechanistic aspects Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study The use of 24-h ambulatory blood pressure monitoring (ABPM) during the first cycle of sunitinib improves the diagnostic accuracy and management of hypertension in patients with advanced renal cancer Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress Rho kinase inhibition mitigates sunitinib-induced rise in arterial pressure and renal vascular resistance but not increased renal sodium reabsorption The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system Renal soluble guanylate cyclase is downregulated in sunitinib-induced hypertension Maximum value of home blood pressure a novel indicator of target organ damage in hypertension Assessment and management of bloodpressure variability PKPD modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as predictors of tumor dynamics and overall survival following sunitinib treatment in GIST Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels Greater sensitivity of blood pressure than renal toxicity to tyrosine kinase receptor inhibition with sunitinib Impaired endothelium-dependent vasodilation does not initiate the development of sunitinib-associated hypertension Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats Determination of sunitinib in human plasma using liquid chromatography coupled with mass spectrometry Sunitinib LC-MS/MS assay in mouse plasma and brain tissue: application in CNS distribution studies Nitrite and nitrate determinations in plasma -a critical-evaluation Pharmacokinetics, distribution, and metabolism of C-14 sunitinib in rats, monkeys, and humans Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction Polymorphisms in endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) predict sunitinib-induced hypertension Endothelin inhibits thick ascending limb chloride flux via ET(B) receptor-mediated NO release Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans A reliable index for the prognostic significance of blood pressure variability Drug surveillance study of amlodipine in patients with hypertension not controlled with drug therapy: NORCON study Macitentan: entry-intohumans study with a new endothelin receptor antagonist Receptor tyrosine kinase inhibition, hypertension, and proteinuria: is endothelin the smoking gun? Role of endothelin-1 in clinical hypertension: 20 years on Systemic therapies for malignant pheochromocytoma and paraganglioma can exacerbate hypertension Molecular basis of hypertension side effects induced by sunitinib In the previous studies, sunitinib and antihypertensive agents were administered simultaneously, which may have yielded dramatic fluctuations in blood pressure; e.g., the antihypertensive treatment proposed by Witte et al. doubled blood pressure fluctuation levels compared to that in subjects that did not receive antihypertensive treatment.


id: cord-012770-wvf8swyj
author: Sun, Shu-zhen
date: 2019-09-12
extension: .txt
mime: text/plain
words: 5378
sentence: 236
flesch: 45
cache: cache/cord-012770-wvf8swyj.txt
txt: txt/cord-012770-wvf8swyj.txt
title:
  β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK(1/2)-NF-κB signal pathway in murine hearts

summary:
  Therefore, β-arrestins have emerged as key regulators of cellular functions [6] , including controlling GPCRdependent chemotactic signals in immune cells during inflammatory reactions. Due to their various biochemical functions in the regulation of critical physiological and pathophysiological processes, including inflammation, β-arrestins have become a drug target in human diseases, such as heart failure.


id: cord-012723-2bbd30ud
author: Wu, Lei
title: Endothelin-1 enhances acid-sensing ion channel currents in rat primary sensory neurons
date: 2020-02-27
extension: .txt
mime: text/plain
words: 5843
sentence: 270
flesch: 51
cache: cache/cord-012723-2bbd30ud.txt
txt: txt/cord-012723-2bbd30ud.txt
summary:
  Since both endothelin receptors and ASICs are distributed in DRG neurons, we hypothesized that there may be an interaction between endothelin receptors and ASICs in the same DRG neuron. In current-clamp recording, pre-application with ET-1 (30 nM) significantly increased acid-evoked firing in rat DRG neurons.


id: cord-012758-18c1rxg8
author: Wu, Xiao-li
title: Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury
date: 2020-02-27
extension: .txt
mime: text/plain
words: 5969
sentence: 303
flesch: 52
cache: cache/cord-012758-18c1rxg8.txt
txt: txt/cord-012758-18c1rxg8.txt
summary:
  Melatonin protects against ischemic brain injury by pleiotropic mechanisms, including anti-oxidation, anti-inflammation, anti-apoptosis and the reduction of autophagic cell death In addition, the recent discoveries that MT agonists attenuate ischemic brain injury further shed light on MTs as promising drug targets for stroke therapy [15, 16] .


id: cord-012768-9fvumvdc
author: Chen, Bao-yi
date: 2020-03-05
extension: .txt
mime: text/plain
words: 6104
sentence: 253
flesch: 41
cache: cache/cord-012768-9fvumvdc.txt
txt: txt/cord-012768-9fvumvdc.txt
title:
  SGK1 mediates the hypotonic protective effect against H(2)O(2)-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway

summary:
  Hypotonic challenge prevents the loss of MMP and the release of Cyt-c via SGK1 H 2 O 2 -induced apoptosis is regulated by the loss of MMP. The results showed that increased SGK1 prevented H 2 O 2 -induced apoptosis in BASMCs.


id: cord-012834-h9lrtecc
author: Yu, Hai-tao
date: 2019-11-25
extension: .txt
mime: text/plain
words: 5723
sentence: 223
flesch: 43
cache: cache/cord-012834-h9lrtecc.txt
txt: txt/cord-012834-h9lrtecc.txt
title:
  Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

summary:
  Zn reduces ECT Cd uptake as an MT-independent protection from Cd toxicity Cd and Zn are known to compete for cellular uptake via metal transporters and therefore Zn inhibition of Cd uptake could function as an MT-independent mechanism to reduce Cd toxicity. We confirmed the adaptive role of HO-1 related to ECT Cd toxicity using an HO-1 inhibitor (ZnPP), which increased ECT sensitivity to Cd toxicity.


id: cord-329011-spiuqngp
author: Huang, Yuan
date: 2020-08-03
extension: .txt
mime: text/plain
words: 6074
sentence: 236
flesch: 45
cache: cache/cord-329011-spiuqngp.txt
txt: txt/cord-329011-spiuqngp.txt
title:
  Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

summary:
  In addition, the SARS-CoV-2 S CTD binding interface has more residues that directly interact with the receptor ACE2 than does SARS-RBD (21 versus 17), and a larger surface area is buried with SARS-CoV-2 S CTD in complex with ACE2 than with SARS S RBD. The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex Site-specific glycan analysis of the SARS-CoV-2 spike Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein Coronavirus membrane fusion mechanism offers a potential target for antiviral development Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity Structural and functional basis of SARS-CoV-2 entry by using human ACE2 Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells Heptad repeat sequences are located adjacent to hydrophobic regions in several types of virus fusion glycoproteins Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus Peptide-based membrane fusion inhibitors targeting HCoV-229E spike protein HR1 and HR2 domains Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors


id: cord-012720-eoovm5gh
author: Liu, Qi
date: 2020-01-14
extension: .txt
mime: text/plain
words: 6081
sentence: 268
flesch: 38
cache: cache/cord-012720-eoovm5gh.txt
txt: txt/cord-012720-eoovm5gh.txt
title:
  Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway

summary:
  The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis Diverse functions of VDUP1 in cell proliferation, differentiation, and diseases Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases Macrophage migration inhibitory factor interacts with thioredoxin-interacting protein and induces NF-κB activity Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses Vitamin D3 upregulated protein 1 suppresses TNF-α-induced NF-κB activation in hepatocarcinogenesis Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production Decreased expression of thioredoxin interacting protein mRNA in inflamed colonic mucosa in patients with ulcerative colitis Epidemiology of inflammatory bowel diseases from west to east Inflammatory bowel disease: clinical aspects and established and evolving therapies Herbal medicine in the treatment of ulcerative colitis Cerebral sinus thrombosis occurring in a patient with ulcerative colitis treated with the Chinese herbal medicine YanNan BaiYao Huangqin-Tang and ingredients in modulating the pathogenesis of ulcerative colitis Wogonoside induces growth inhibition and cell cycle arrest via promoting the expression and binding activity of GATA-1 in chronic myelogenous leukemia cells New therapeutic aspects of flavones: the anticancer properties of scutellaria and its main active constituents wogonin, baicalein and baicalin Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury Puerarin inhibits hyperglycemiainduced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway Animal models of intestinal inflammation: ineffective communication between coalition members Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome Diversity of intestinal macrophages in inflammatory bowel diseases Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation Apoptosisassociated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn's disease (CD), in Chinese Han population Inflammasomes and intestinal inflammation Structure and interdomain dynamics of apoptosis-associated specklike protein containing a CARD (ASC) Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme Canonical and non-canonical activation of NLRP3 inflammasome at the crossroad between immune tolerance and intestinal inflammation Inflammasomes: mechanism of action, role in disease, and therapeutics Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation QL and RZ contributed to the animal experiments, cell experiments, and data analysis. It was shown that oroxindin reduced NLRP3 inflammasome protein expression in LPS-stimulated THP-1 cells (Fig. 5a) .


id: cord-012838-23odny3f
author: Lai, Qiong
date: 2020-03-02
extension: .txt
mime: text/plain
words: 6463
sentence: 283
flesch: 41
cache: cache/cord-012838-23odny3f.txt
txt: txt/cord-012838-23odny3f.txt
title:
  Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies

summary:
  Principal component and orthogonal partial least squares discriminant analyses of serum and urine samples Principal component analysis (PCA) was used to perform unsupervised data analysis on the sham, model and SA groups. The OPLS-DA model was constructed to determine the distinction of metabolic patterns between the model group and SA group in both the positive and negative ion modes.


id: cord-013717-e0cai9j3
author: Fusi, Fabio
date: 2020-03-04
extension: .txt
mime: text/plain
words: 7179
sentence: 267
flesch: 45
cache: cache/cord-013717-e0cai9j3.txt
txt: txt/cord-013717-e0cai9j3.txt
title:
  Ritanserin blocks Ca(V)1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies

summary:
  Therefore, patch-clamp, functional, and moleculardocking analyses of ritanserin effects were performed on rat tail arteries. Ritanserin concentration-dependently shifted the voltage dependence of the steady-state inactivation curve to more negative potentials (K(i) = 1.58 µM) without affecting the slope of inactivation and the activation curve, and decreased I(Ca1.2) progressively during repetitive (1 Hz) step depolarizations (use-dependent block).


id: cord-300445-qzu4gz2d
author: Zhang, Xiao-lei
date: 2020-09-23
extension: .txt
mime: text/plain
words: 7259
sentence: 315
flesch: 34
cache: cache/cord-300445-qzu4gz2d.txt
txt: txt/cord-300445-qzu4gz2d.txt
title:
  Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives

summary:
  Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Later, under a limited emergency-use authorization from the FDA, hydroxychloroquine in combination with azithromycin was used to treat COVID-19 patients in the USA, although the mechanisms of the anti-COVID-19 effects remain unclear.


id: cord-012682-7goljir4
author: Yuan, Meng
title: N-myristoylation: from cell biology to translational medicine
date: 2020-03-18
extension: .txt
mime: text/plain
words: 7201
sentence: 279
flesch: 33
cache: cache/cord-012682-7goljir4.txt
txt: txt/cord-012682-7goljir4.txt
summary:
  Protein lipidation in cell signaling and diseases: function, regulation, and therapeutic opportunities Protein lipidation SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2 Protein lysine acylation and cysteine succination by intermediates of energy metabolism Protein myristoylation in health and disease Cholesterol sensitivity of endogenous and myristoylated Akt Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis Inhibition of enterovirus VP4 myristoylation is a potential antiviral strategy for hand, foot and mouth disease N-Terminal region of the catalytic domain of human Nmyristoyltransferase 1 acts as an inhibitory module HIV-1 production is specifically associated with human NMT1 long form in human Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction Fatty acids regulate germline Sex determination through ACS-4-dependent myristoylation Comparison of myristoyl-CoA: protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation Nmyristoyltransferase 1 is essential in early mouse development Protein kinase C coordinates histone H3 phosphorylation and acetylation Molecular determinants of the myristoyl-electrostatic switch of MARCKS Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching Structure and membrane interaction of myristoylated ARF1 Sequestration of the membranetargeting myristoyl group of recoverin in the calcium-free state Myristoylation-dependent N-terminal cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cellular extracts A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes C-terminal 15 kDa fragment of cytoskeletal actin is posttranslationally N-myristoylated upon caspase-mediated cleavage and targeted to mitochondria N-Terminally myristoylated ras proteins require palmitoylation or a polybasic domain for plasmamembrane localization Membrane localization of a rice calcium-dependent protein kinase (CDPK) is mediated by myristoylation and palmitoylation Myristoylationdependent palmitoylation of the receptor tyrosine kinase adaptor FRS2alpha G proteinmembrane interactions I: Galphai1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization Identification and characterization of protein N-myristoylation occurring on four human mitochondrial proteins, SAMM50, TOMM40, MIC19, and MIC25 Role of N-myristoylation in stability and subcellular localization of the CLPABP protein Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment N-Myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system Aggregation of lipid-anchored full-length H-Ras in lipid bilayers: simulations with the MARTINI force field A dimerization function in the intrinsically disordered N-terminal region of Src A myristoyl-binding site in the SH3 domain modulates c-Src membrane anchoring Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin A myristoyl switch regulates membrane binding of HIV-1 Gag Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction Heme oxygenase 2 binds myristate to regulate retrovirus assembly and TLR4 signaling A glycine-specific Ndegron pathway mediates the quality control of protein N-myristoylation Myristoylation and membrane binding regulate c-Src stability and kinase activity ABA inhibits myristoylation and induces shuttling of the RGLG1 E3 ligase to promote nuclear degradation of PP2CA A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis A myristoyl/phosphotyrosine switch regulates c-Abl beta-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMPactivated protein kinase (AMPK) N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation Exploring protein myristoylation in Toxoplasma gondii Liberated PKA Catalytic subunits associate with the membrane via myristoylation to preferentially phosphorylate membrane substrates Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members Potential role of N-myristoyltransferase in cancer Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog Myristic acid increases the activity of dihydroceramide Delta 4-desaturase 1 through its Nterminal myristoylation Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion Myristoylation of human LanC-like Protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin Effects of L-histidine and its structural analogues on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity Expression and activity of N-myristoyltransferase in lung inflammation of cattle and its role in neutrophil apoptosis Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-gammaproducing gamma delta T cells Myristoylation: an important protein modification in the immune response N-myristoylation of AMPK controls T cell inflammatory function The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX Novel analogs of D-e-MAPP and B13.


id: cord-012035-rhpfpku9
author: Zhong, Hui-hai
title: TRAIL-based gene delivery and therapeutic strategies
date: 2019-08-23
extension: .txt
mime: text/plain
words: 8766
sentence: 359
flesch: 35
cache: cache/cord-012035-rhpfpku9.txt
txt: txt/cord-012035-rhpfpku9.txt
summary:
  Codelivery of pTRAIL and monensin using dualtargeting and stimuli-responsive self-assembling nanocomposites TRAIL and chemotherapeutic drugs in cancer therapy Evaluation of efficiency of modified polypropylenimine (PPI) with alkyl chains as non-viral vectors used in co-delivery of doxorubicin and TRAIL plasmid In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer Gene and doxorubicin codelivery system for targeting therapy of glioma Choline-derivate-modified nanoparticles for brain-targeting gene delivery Choline transporter-targeting and codelivery system for glioma therapy Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo MSC-delivered soluble TRAIL and paclitaxel as novel combinatory treatment for pancreatic adenocarcinoma In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus Is TRAIL the holy grail of cancer therapy? SAHA (vorinostat) facilitates functional polymer-based gene transfection via upregulation of ROS and synergizes with TRAIL gene delivery for cancer therapy Histone deacetylase inhibitor panobinostat potentiates the anti-cancer effects of mesenchymal stem cell-based sTRAIL gene therapy against malignant glioma Synergistic antitumor effects of CDK inhibitor SNS032 and an oncolytic adenovirus coexpressing TRAIL and Smac in pancreatic cancer Combination of AAV-TRAIL with miR-221-Zip therapeutic strategy overcomes the resistance to TRAIL induced apoptosis in liver cancer Competing interests: The authors declare no competing interests. DR5 is the highest affinity receptor Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling Getting TRAIL back on track for cancer therapy Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosisinducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody(R) targeting the DR5 receptor Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous nonsmall-cell lung cancer Trailing TRAIL resistance: novel targets for TRAIL sensitization in cancer cells TRAIL and apoptosis induction by TNF-family death receptors Nanocarriers for TRAIL delivery: driving TRAIL back on track for cancer therapy Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene Membrane-bound Fas ligand only is essential for Fas-induced apoptosis Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells Polymers for gene delivery across length scales Overcoming gene-delivery hurdles: physiological considerations for nonviral vectors Adenoviralmediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: first evidence in preclinical hepatocellular carcinoma Non-viral vectors for gene-based therapy Design and development of polymers for gene delivery Nonviral vectors for gene delivery Barriers to nonviral gene delivery Progress in developing cationic vectors for non-viral systemic gene therapy against cancer A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Toxicity of cationic lipids and cationic polymers in gene delivery New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment The use of myristic acid as a ligand of polyethylenimine/DNA nanoparticles for targeted gene therapy of glioblastoma A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy Poly-gamma-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery Nano-structural effects on gene transfection: large, botryoid-shaped nanoparticles enhance DNA delivery via macropinocytosis and effective dissociation Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing Esterase-activated chargereversal polymer for fibroblast-exempt cancer gene therapy Enzyme-responsive charge-reversal polymer-mediated effective gene therapy for intraperitoneal tumors Sandwich-type Au-PEI/DNA/PEI-Dexa nanocomplex for nucleus-targeted gene delivery in vitro and in vivo Nanoparticlemediated target delivery of TRAIL as gene therapy for glioblastoma Antitumor effect of human TRAIL on adenoid cystic carcinoma using magnetic nanoparticle-mediated gene expression Discovery of dendrimers and dendritic polymers: a brief historical perspective Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma Therapeutic efficacy of intravenously administered transferrin-conjugated dendriplexes on prostate carcinomas Regression of prostate tumors after intravenous administration of lactoferrinbearing polypropylenimine dendriplexes encoding TNF-alpha, TRAIL, and interleukin-12 A self-assembled coumarin-anchored dendrimer for efficient gene delivery and light-responsive drug delivery Triazine-modified dendrimer for efficient TRAIL gene therapy in osteosarcoma Modified PAMAM vehicles for effective TRAIL gene delivery to colon adenocarcinoma: in vitro and in vivo evaluation Peptide-guided gene delivery Development of a genetically engineered biomimetic vector for targeted gene transfer to breast cancer cells Intratracheal administration of a nanoparticle-based therapy with the angiotensin II type 2 receptor gene attenuates lung cancer growth PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma Advancing nonviral gene delivery: lipid-and surfactant-based nanoparticle design strategies A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA Targeting tumor-associated fibroblasts for therapeutic delivery in desmoplastic tumors A multifunctional nanocarrier for efficient TRAIL-based gene therapy against hepatocellular carcinoma with desmoplasia in mice core-shell nanoparticles-based gene delivery for treatment of aggressive melanoma Multifunctional nucleus-targeting nanoparticles with ultra-high gene transfection efficiency for in vivo gene therapy Minimal criteria for defining multipotent mesenchymal stromal cells Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies How do mesenchymal stromal cells exert their therapeutic benefit?


id: cord-314714-ehxxvenb
author: Pang, Xiaocong
title: Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication
date: 2020-06-24
extension: .txt
mime: text/plain
words: 1226
sentence: 40
flesch: 30
cache: cache/cord-314714-ehxxvenb.txt
txt: txt/cord-314714-ehxxvenb.txt
summary:
  Currently, phase I (NCT00886353) and phase II (NCT01597635) clinical studies with a recombinant version of the catalytic ectodomain of human ACE2 (GSK2586881) have been successfully completed, providing safety and efficacy for ARDS treatment [25, 26] . key: cord-314714-ehxxvenb authors: Pang, Xiaocong; Cui, Yimin; Zhu, Yizhun title: Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication date: 2020-06-24 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-020-0430-6 sha: doc_id: 314714 cord_uid: ehxxvenb nan cardiovascular disease through modulating ACE2 activation and expression to increase Ang 1-7 production and improve vascular function [17] .


id: cord-012795-6m88m81v
author: Yu, Hai-jun
title: Nanomedicine and cancer immunotherapy
date: 2020-05-28
extension: .txt
mime: text/plain
words: 1839
sentence: 68
flesch: 23
cache: cache/cord-012795-6m88m81v.txt
txt: txt/cord-012795-6m88m81v.txt
summary:
  The prime aim for the special issue is to deliver both high-impact review and research articles to the wide international readership regarding the most recent progress in nano-immunotherapy as well as the approaches for enhancing the efficacy of cancer immunotherapy. Therefore, cancer immunotherapy is considered as an effective treatment modality to eliminate primary and metastatic tumors as well as to establish immunological memory.


id: cord-012778-yr8zuvw9
author: Zhang, Lei
date: 2019-08-06
extension: .txt
mime: text/plain
words: 5060
sentence: 212
flesch: 41
cache: cache/cord-012778-yr8zuvw9.txt
txt: txt/cord-012778-yr8zuvw9.txt
title:
  Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China

summary:
  All of these evaluation results indicated good predictability of the final models. Typical drug efficacy values According to the final model parameters, we examined the efficacy values of the three antipsychotics at 26, 52, 78, 104, 130, and 156 weeks and simulated the typical efficacy-time curves (Fig. 3a) . The CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) schizophrenia study conducted by the National Institute of Mental Health (NIMH) is the most wellknown comparative study of the effectiveness of antipsychotic drugs [10, 11] .


id: cord-012771-3ukffdmq
author: Xu, Deng-qiu
title: The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis
date: 2020-01-14
extension: .txt
mime: text/plain
words: 4700
sentence: 212
flesch: 38
cache: cache/cord-012771-3ukffdmq.txt
txt: txt/cord-012771-3ukffdmq.txt
summary:
  Thus, catalpol improves skeletal muscle mitochondrial function by activating AMPK-mediated mitochondrial biogenesis. As we reported previously, catalpol improved skeletal muscle mitochondrial function [25] .


id: cord-012760-p6fdc191
author: Liu, Can-zhao
date: 2019-09-04
extension: .txt
mime: text/plain
words: 4329
sentence: 171
flesch: 33
cache: cache/cord-012760-p6fdc191.txt
txt: txt/cord-012760-p6fdc191.txt
title:
  Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

summary:
  Endophilin A2 regulates the expression of TMEM16A protein Next, to evaluate how endophilin A2 modulates TMEM16A CaCC activity in smooth muscle cells, we determined the mRNA and protein levels of TMEM16A with overexpression or knockdown of endophilin A2. Upregulation of TMEM16A ubiquitination by endophilin A2 as a prerequisite for selective autophagy-mediated degradation In our study, we showed that angiotensin II induced a decrease in TMEM16A protein in BASMCs.


id: cord-012826-72mz834w
author: Xu, Zhen-dong
date: 2019-10-23
extension: .txt
mime: text/plain
words: 4798
sentence: 194
flesch: 43
cache: cache/cord-012826-72mz834w.txt
txt: txt/cord-012826-72mz834w.txt
title:
  Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy

summary:
  Propofol at clinical concentrations (10 µM) significantly induces the release of more Ca 2+ from the ER into the cytosol in ATG5 −/− cells than in WT cells via the activation of inositol-1,4,5-trisphosphate receptor (InsP 3 R) and/or ryanodine receptor (RyR) calcium channels, favoring cell survival and proliferation The role of autophagy during the early neonatal starvation period Atg5 is essential for the development and survival of innate lymphocytes Involvement of autophagy in NK cell development and function Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium Calcium homeostasis and ER stress in control of autophagy in cancer cells Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB *P < 0.05, **P < 0.01, or ***P < 0.001, respectively General anesthetics and autophagy ZD Xu et al. (200 µM) decreased the total cell numbers more significantly in ATG5 −/− cells than in WT cells (Fig. 2a-c) .


id: cord-012785-d53k16ow
author: Zhang, Shi-rong
date: 2020-02-17
extension: .txt
mime: text/plain
words: 5033
sentence: 197
flesch: 46
cache: cache/cord-012785-d53k16ow.txt
txt: txt/cord-012785-d53k16ow.txt
title:
  Chalcomoracin inhibits cell proliferation and increases sensitivity to radiotherapy in human non-small cell lung cancer cells via inducing endoplasmic reticulum stress-mediated paraptosis

summary:
  Studies have revealed that natural products can sensitize cancer cells to radiation therapy [23, 24] . This evidence indicates that CMR kills cancer cells through paraptosis.


id: cord-012754-yp66g40r
author: Zhang, Na
date: 2020-01-13
extension: .txt
mime: text/plain
words: 5047
sentence: 231
flesch: 50
cache: cache/cord-012754-yp66g40r.txt
txt: txt/cord-012754-yp66g40r.txt
title:
  A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression

summary:
  These results suggest that IMB-S7 inhibits HSCs activation and liver fibrosis through Sp1-integrin αv signaling, and IMB-S7 may be a promising candidate to combat hepatic fibrosis in the future. Liver fibrosis, which is characterized by excessive extracellular matrix (ECM) deposition resulting from chronic liver injury of different etiologies, represents a major health problem worldwide.


id: cord-012688-d0m23sgk
author: Zheng, Xu-yong
date: 2020-04-27
extension: .txt
mime: text/plain
words: 5439
sentence: 251
flesch: 50
cache: cache/cord-012688-d0m23sgk.txt
txt: txt/cord-012688-d0m23sgk.txt
title:
  Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy

summary:
  In conclusion, this study demonstrates that MyD88 inhibitor LM9 exerts protective effects against obesity-induced cardiomyopathy, suggesting LM9 to be a promising therapeutic candidate drug for the obesity-related cardiac complications. Due to the obesity process, ongoing chronic inflammation causes infiltration of inflammatory cells and progressive changes in tissue destruction and remodeling [3, 12] .


id: cord-012806-pjehkeh9
author: Zhou, Zhong-yan
title: Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo
date: 2019-09-12
extension: .txt
mime: text/plain
words: 4989
sentence: 228
flesch: 48
cache: cache/cord-012806-pjehkeh9.txt
txt: txt/cord-012806-pjehkeh9.txt
summary:
  Timo AIII treatment also significantly inhibited VEGF-triggered phosphorylation of VEGFR2, Akt, and ERK1/2 in HUVECs. key: cord-012806-pjehkeh9 authors: Zhou, Zhong-yan; Zhao, Wai-rong; Xiao, Ying; Zhou, Xiang-ming; Huang, Chen; Shi, Wen-ting; Zhang, Jing; Ye, Qing; Chen, Xin-lin; Tang, Jing-yi title: Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo date: 2019-09-12 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-019-0291-z sha: doc_id: 12806 cord_uid: pjehkeh9 Timosaponin AIII (Timo AIII) is a natural steroidal saponin isolated from the traditional Chinese herb Anemarrhena asphodeloides Bge with proved effectiveness in the treatment of numerous cancers.


id: cord-012822-8t6qg5fp
author: Papoutsis, Konstantinos
date: 2020-02-05
extension: .txt
mime: text/plain
words: 5491
sentence: 192
flesch: 30
cache: cache/cord-012822-8t6qg5fp.txt
txt: txt/cord-012822-8t6qg5fp.txt
title:
  Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans

summary:
  Phenotypes per group Study groups and subcategorization along with baseline characteristics have been previously described [9] . Similarly, RL2 tissue levels were increased in comparison to MMP2, MMP9, and eNOS levels (P < 0.05).


id: cord-013601-y8pc4qfc
author: Zhou, Bo-ya
date: 2020-04-23
extension: .txt
mime: text/plain
words: 6163
sentence: 253
flesch: 42
cache: cache/cord-013601-y8pc4qfc.txt
txt: txt/cord-013601-y8pc4qfc.txt
title:
  Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization

summary:
  Sorafenib, a potent TKI targeting VEGFR2 and PDGFRβ, has been shown to effectively inhibit keloid cell proliferation, migration, invasion, and collagen production [5] . It has been shown that the keloid mechanism involves multiple signaling pathways, such as VEGF, PDGF, FGF, and TGF-β, but there has been no report on a drug that could target more than three growth factors among the studies on drugs targeting keloid cell behavior [5, 14, 15] .


id: cord-012818-zr4xw3ph
author: Zhang, Ying-ying
date: 2020-02-12
extension: .txt
mime: text/plain
words: 6290
sentence: 231
flesch: 26
cache: cache/cord-012818-zr4xw3ph.txt
txt: txt/cord-012818-zr4xw3ph.txt
title:
  A comparative pharmacogenomic analysis of three classic TCM prescriptions for coronary heart disease based on molecular network modeling

summary:
  Nat Rev Cardiol Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism? Salivary lysozyme and prevalent coronary heart disease: possible effects of oral health on endothelial dysfunction Assessing salivary C-reactive protein: longitudinal associations with systemic inflammation and cardiovascular disease risk in women exposed to intimate partner violence Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases Effect of bile acid sequestrants on the risk of cardiovascular events: a mendelian randomization analysis The association of bile acid excretion and atherosclerotic coronary artery disease Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1 Emerging regulators of vascular smooth muscle cell function in the development and progression of atherosclerosis Shared risk factors in cardiovascular disease and cancer Transfer of IP(3) through gap junctions is critical, but not sufficient, for the spread of apoptosis Cx43 phosphorylation on S279/ 282 and intercellular communication are regulated by IP3/IP3 receptor signaling Cardiovascular actions of insulin Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells Insulin and myocardial blood flow Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats Insulin attenuates agonistmediated calcium mobilization in cultured rat vascular smooth muscle cells Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity ABC transporters, atherosclerosis and inflammation Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets Vascular lipases, inflammation and atherosclerosis Glycerolipid metabolism and signaling in health and disease Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis Vitamin D and cardiovascular disease Vitamin C and heart health: a review based on findings from epidemiologic studies Homocysteine, folate and vitamin b12 in patients with coronary heart disease Comprehensive plasma metabolomic analyses of atherosclerotic progression reveal alterations in glycerophospholipid and sphingolipid metabolism in apolipoprotein E-deficient mice Association between local atherosclerosis and renal cell carcinomas Risk factors for coronary heart disease in type II diabetes mellitus Insulin resistance implications for type II diabetes mellitus and coronary heart disease Multi-hierarchical profiling: an emerging and quantitative approach to characterizing diverse biological networks Network biology: understanding the cell's functional organization A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs key: cord-012818-zr4xw3ph authors: Zhang, Ying-ying; Zhao, Zi-de; Kong, Peng-yun; Gao, Lin; Yu, Ya-nan; Liu, Jun; Wang, Peng-qian; Li, Bing; Zhang, Xiao-xu; Yang, Li-qiang; Wang, Zhong title: A comparative pharmacogenomic analysis of three classic TCM prescriptions for coronary heart disease based on molecular network modeling date: 2020-02-12 journal: Acta Pharmacol Sin DOI: 10.1038/s41401-019-0352-3 sha: doc_id: 12818 cord_uid: zr4xw3ph Traditional Chinese medicine (TCM) has evolved over several thousands of years, which has been shown to be efficacious in the treatment of ischemic heart disease.


id: cord-012802-xm2ftrw2
author: Zhao, Wu-li
date: 2020-01-13
extension: .txt
mime: text/plain
words: 7551
sentence: 273
flesch: 46
cache: cache/cord-012802-xm2ftrw2.txt
txt: txt/cord-012802-xm2ftrw2.txt
title:
  The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation

summary:
  These results showed that IMB-HDC possessed a stronger anticancer effect compared with its parent sophoridinol. IMB-HDC induces cell apoptosis via the mitochondria-mediated apoptotic pathway Cell apoptosis was assessed by flow cytometric analysis, and the results showed that IMB-HDC could extensively induce HCT-8 cells apoptosis in a dose-dependent manner, and at lower concentrations of 1 μM and 2 μM, the total apoptotic cells were 10.04% and 40% of the untreated cells, respectively, and at the higher concentration of 4 μM, the ratio was up to 65% (Fig. 2a) , indicating that IMB-HDC plays its anticancer role in apoptosis inducement. To evaluate the effect of IMB-HDC on tumor cells, 5 μM IMB-HDC was added into the human colon carcinoma cell HCT-8, and cell morphology was observed at 3, 7, and


id: cord-013567-qnp65w53
author: Cheng, Qiao-qiao
date: 2020-03-12
extension: .txt
mime: text/plain
words: 7187
sentence: 313
flesch: 38
cache: cache/cord-013567-qnp65w53.txt
txt: txt/cord-013567-qnp65w53.txt
title:
  Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction

summary:
  Measurement of real-time mitochondrial respiration in living H9c2 cells using a Seahorse XFe96 Extracellular Flux Analyzer showed that mitochondrial respiration in H9c2 cells, including basal respiration, maximal respiration, and ATP production, was strongly inhibited by H 2 O 2 treatment. In the present study, the protective effects of GAS on H9c2 cells against ischemia–reperfusion (IR)-like injury were found to be related to decreasing of oxidative stress.


id: cord-013591-goaokk04
author: Ren, Si-yu
date: 2020-03-18
extension: .txt
mime: text/plain
words: 7190
sentence: 251
flesch: 23
cache: cache/cord-013591-goaokk04.txt
txt: txt/cord-013591-goaokk04.txt
title:
  Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors

summary:
  The review explains the endocannabinoid system and eventually discusses two key types of enzyme inhibitors of the ECS: FAAH inhibitors and MAGL inhibitors. To produce antidepressant or anxiolytic effects, FAAH inhibitors may alter the response of the HPA axis and modulate its function, while MAGL inhibitors may be beneficial in suppressing CNS inflammation, thus ameliorating the depression or anxiety caused by different physiological mechanisms


id: cord-012773-wtgk2d68
author: Xu, Ming-ming
title: Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
date: 2019-10-04
extension: .txt
mime: text/plain
words: 10786
sentence: 411
flesch: 37
cache: cache/cord-012773-wtgk2d68.txt
txt: txt/cord-012773-wtgk2d68.txt
summary:
  A known modulator of α-syn aggregation, anle138b (20) , was found to exhibit a significant increase in fluorescence upon binding to α-syn fibrils with high affinity (K d = 190 nM) As a main metabolite of green tea polyphenols, protocatechuic acid (48) is able to inhibit α-syn aggregation, disaggregate preformed α-syn fibrils and protect PC12 cells from toxicity caused by α-syn aggregates [133] .


id: cord-278523-djjtgbh6
author: Zhou, Bei-xian
date: 2020-06-05
extension: .txt
mime: text/plain
words: 11767
sentence: 500
flesch: 45
cache: cache/cord-278523-djjtgbh6.txt
txt: txt/cord-278523-djjtgbh6.txt
title:
  β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling

summary:
  We confirmed the anti-apoptotic effect of βsitosterol by measuring the active caspase-3 and its substrate PARP, observing that these products were found in cells transfected with vRNA but not in those treated with β-sitosterol Fig. 4 (continued) β-Sitosterol ameliorates IAV-induced inflammation and ALI BX Zhou (Fig. 5b) . Moreover, β-sitosterol treatment attenuated RIG-I-mediated apoptotic injury of alveolar epithelial cells (AEC) via downregulation of pro-apoptotic factors.


# ent

id: cord-012773-wtgk2d68
sid: 381
eid: 2
type: ORG
entity:
  niger de soemmering avec quelques déductions relatives à la pathogénie des troubles du tonus musculaire et de la maladie de parkinson


