Erratum to the paper: In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery


doi: 10.5599/admet.568 267 

ADMET & DMPK 6(3) (2018) 267-268; doi: http://dx.doi.org/10.5599/admet.568 

 
Open Access : ISSN : 1848-7718  

http://www.pub.iapchem.org/ojs/index.php/admet/index   

Erratum 

Erratum to the paper: In vitro membrane binding and protein 
binding (IAM MB/PB technology) to estimate in vivo 
distribution: applications in early drug discovery  

Klara Valko*
1
, Simon Teague

2
, Charles Pudgeon

3
 

 
1
Bio-Mimetic Chromatography Ltd, Unit 5B Business & Technology Centre, Stevenage, SG1 2DX Hertfordshire United 

Kingdom  
2
GlaxoSmithKline, Stevenage, United Kingdom  

3
 Independent Researcher, affiliate of Regis Technologies Inc, Morton Grove, IL 60052 USA 

 *Corresponding Author:  E-mail: Klara_Valko@bio-mimetic-chromatofraphy.com; Tel.: +44-7521-989558 

Received: July 11, 2018; Revised: July 12, 2018; Available online: July 15, 2018  

 

 
 
 

The authors of the original paper published with the same title [1] apologize for the error in the plot on 

Figure 5. 

The correct plot, statistics and explanation in Figure 5 on page 25 using the published data in the 

Appendix Table A1 and A2 by equation 3 are shown below. 

“In turn, the volume of distribution of marketed drugs could be modeled by the difference in the 

membrane and the protein binding of compounds as described by Equation 3 and shown in Figure 5 for the 

investigated compounds. There are only 40 compounds that have been included in the training set, the 

majority of the compounds were not included in the original model. That explains that the statistics are 

slightly worse (r
2 

= 0.76; root mean square error = 0.33 in the original model, while here the r
2 

= 0.65 and 

root mean square error = 0.40). “ 

It is considered as an excellent prediction of the in vivo behaviour of the compounds using only two 

measured biomimetic properties, namely the IAM membrane binding and the HSA protein binding (see the 

original paper for details). 

http://www.pub.iapchem.org/ojs/index.php/admet/index
mailto:Klara_Valko@bio-mimetic-chromatofraphy.com


Klara Valko et al.  ADMET & DMPK 6(3) (2018) 267-268 

268  

 
Figure 5. The observed in vivo log Vdss vs the estimated Vdss by the IAM MB/PB Technology® using Equation 3. 

 
 

References 

[1] K. Valko, S. Teague, C. Pudgeon. In vitro membrane binding and protein binding (IAM MB/PB 
technology) to estimate in vivo distribution: applications in early drug discovery. ADMET & DMPK 
5(1) (2017) 14-38. https://dx.doi.org/10.5599/admet.5.1.373  

 
 
 

©2018 by the authors; licensee IAPC, Zagreb, Croatia. This article is an open-access article distributed under the terms and 
conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)  

 

 

 

 

 

https://dx.doi.org/10.5599/admet.5.1.373
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