id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-10	Tam, Kin	Estimating the “First in human” dose – a revisit with particular emphases in oncology drugs	2013	13	.pdf	application/pdf	6300	270	43	Conversion factors of animal doses to human equivalent doses [3] Species To convert animal dose in mg/kg to HED mg/m 2 , multiply by km + To convert animal dose in mg/kg to HED* in mg/kg, either: Divide animal dose by Multiply animal dose by Human 37 Mouse 3 12.3 0.08 Hamster 5 7.4 0.13 There are additional considerations in the design of FIH dose for molecular targeted anticancer compounds.	cache/admet-10.pdf	txt/admet-10.txt