id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-142	Wakuda, Hirokazu; Miyauchi, Shino; Maruyama, Kana; Kagota, Satomi; Nakamura, Kazuki; Umegaki, Keizo; Yamada, Shizuo; Shinozuka, Kazumasa	Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation	2015	7	.pdf	application/pdf	2717	210	63	Changes in the fluorescence of residual rhodamine 123, a marker of P-gp activity, in the apical region of Caco-2 cells were measured in the presence of MAPK pathway inhibitors using time-lapse confocal laser scanning microscopy at 0, 10, 20, 30, and 60 min. Significant differences were observed between the fluorescence levels of control cells and cells treated with SB203580 for 20, 30, or 60 min. In the present study, we evaluated the effects of MAPK pathway inhibitors (SB203580, competitive p38α and β inhibitor; CMPD-1, non-competitive p38α inhibitor; SB239063, competitive p38α and β specific inhibitor; SP600125, competitive JNK 1, 2, 3 inhibitor; FR180204, competitive ERK1/2 inhibitor) on the ADMET & DMPK 3(1)	cache/admet-142.pdf	txt/admet-142.txt