id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-1437	Bonhoeffer, Bastian; Kordikowski, Andreas; John, Edgar; Juhnke, Michael	Numerical modelling of the dissolution of drug nanocrystals and its application to industrial product development	2022	35	.pdf	application/pdf	16829	872	41	The numerical model was then applied to selected industrially relevant in vivo and in vitro scenarios to predict in silico the dissolution in a closed system considering the interplay between input parameters: drug nanocrystal particle size distribution, drug amount, dissolution media and related volume, and output parameters: apparent solubility, remaining drug particle size distribution if any and drug fraction dissolved, all time-resolved up to equilibrium condition. In silico dissolution studies were conducted with the numerical model for selected in vivo and in vitro scenarios to simulate the complex interplay between drug nanocrystal particle size distribution, drug amount, dissolution media and volume, and resulting temporal progression of concentration during dissolution up to equilibrium state as well as remaining drug particle size distribution, if any.	cache/admet-1437.pdf	txt/admet-1437.txt