id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-144	Camenisch, Gian; Riede, Julia; Kunze, Annett; Huwyler, Jörg; Poller, Birk; Umehara, Kenichi	The extended clearance model and its use for the interpretation of hepatobiliary elimination data	2015	14	.pdf	application/pdf	5537	218	40	Keywords extended clearance concept classification system; hepatic elimination; passive permeability; transporters Extended clearance model Historically, hepatic clearance models assumed that (i) the unbound drug concentration in blood is determining the hepatic clearance (metabolism and/or biliary excretion) and that (ii) there is no membrane transport barrier limiting access to the enzymes or transporters in the hepatocyte. Hepatic versus non-hepatic elimination Figure 2 (panel C) illustrates the relationship between passive sinusoidal uptake (PSinf,pas) and the observed (in vivo) fractional contribution of hepatic clearance to overall drug elimination fnh.	cache/admet-144.pdf	txt/admet-144.txt