id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-159	Bates, Christopher A; Fu, Sherleen; Ysselstein, Daniel; Rochet, Jean-Christophe; Zheng, Wei	Expression and Transport of a-Synuclein at the Blood-Cerebrospinal Fluid Barrier and Effects of Manganese Exposure	2015	19	.pdf	application/pdf	8693	478	64	The changes in a-Syn signals in Z310 cells after Mn exposure may reflect a direct interaction of Mn with a- Syn. The data presented in this report suggest that 1) a-Syn is naturally expressed in choroid plexus tissues, particularly within epithelial cells; it is also present in the immortalized choroidal epithelial Z310 cell line; 2) treatment of plexus cells with Mn or Cu induces a-Syn accumulation within the BCB; 3) Mn exposure does not significantly alter a-Syn production at the transcriptional level; 4) in the test tube, incubation of a-Syn with Mn or Cu causes the aggregation of a-Syn; and 5) while Mn exposure does not affect the transport of a-Syn across the BCSFB monolayer, it increases a-Syn uptake by a primary culture of choroidal epithelial cells.	cache/admet-159.pdf	txt/admet-159.txt