id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-258	Berghausen, Joerg; Seiler, Frank Hans; Gobeau, Nathalie; Faller, Bernard	Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range	2016	19	.pdf	application/pdf	8012	377	56	Since the introduction of the human FaSSIF and FeSSIF media, there is an option to obtain solubility values which are more appropriate as input parameters for PBPK simulations and FaSSIF solubility maybe one of the physico-chemical parameters that is determined as one of the first after a compound is sent out for characterization. As a consequence, due to the significant deviations from the linear fit for many compounds, the estimation of bile salt solubility for individual compounds is regarded as not sufficient to support studying ADMET & DMPK 4(1)	cache/admet-258.pdf	txt/admet-258.txt