id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-2961	Pu, Jiang; Yang, Mei; Zhang, Min; Gao, Ruiqi; Xiao, Yue; Liu, Lingyu; Zhang, Chuanjing; Xu, Wennuo; Li, Kaifang; Feng, Wanyong	Elucidating CYP2D6-driven metabolism and hepatotoxic bioactivation of metoprolol in plateable human and animal hepatocytes: Original scientific paper	2025	16	.pdf	application/pdf	7919	474	40	These values are significantly below the 10 mL min-1 kg-1 threshold for low-clearance compounds and align well with previously reported [20,54] with a low clearance of 2.2 ± 0.7 μL min-1 per million cells in plateable human hepatocytes, correlating with an in vivo clearance of 1.4 mL min-1 kg-1 [20] (or 4.28 μL min-1 per million cells [73]), making the plateable hepatocytes particularly valuable for evaluating low-clearance compounds [74]. Human plateable hepatocytes maintained functional cytochrome P450 enzymes and accurately recapitulated metabolism mediated by human recombinant CYP2D6 enzymes, with principal metabolites exhibiting comparable relative abundance profiles (M10, M13, and M17).	cache/admet-2961.pdf	txt/admet-2961.txt