id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-31	Avdeef, Alex	Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs	2014	13	.pdf	application/pdf	4615	270	57	In addition, the formation of drug aggregates can have significant impact on measured in vitro permeability, since aqueous diffusivity of compounds depends on their size, e.g., as was suggested in the Caco-2 study of retinoic acid in neutral solution [6]. Since salt solubility is a conditional constant, depending on the drug and the specific counterion concentrations, the determination of the thermodynamic solubility product allows for scalability of salt effects across a wide range of concentrations of substituents in formulation research.	cache/admet-31.pdf	txt/admet-31.txt