id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-335	Honeywell, Richard J.; Avan, Amir; Giovannetti, Elisa; Peters, Godefridus J.	Tissue distribution of crizotinib and gemcitabine combination in a patient-derived orthotopic mouse model of pancreatic cancer	2016	8	.pdf	application/pdf	3647	194	54	In whole blood gemcitabine was about 1.0 µM and crizotinib 2.4 µM in the single treatment, whereas in the combination crizotinib increased the levels of gemcitabine. We determined tissue distribution of gemcitabine, an antimetabolite, and crizotinib, a tyrosine-kinase inhibitor targeted against the anaplastic lymphoma kinase (ALK) and mesenchymal-epithelial transition factor (c-Met) receptors, in a validated orthotopic mouse model for pancreatic cancer.	cache/admet-335.pdf	txt/admet-335.txt