id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-341	Maddi, Srinivas; Akkireddy, Ravi; Lenkalapelly, Srinivas; Srivastava, Pratima; Boruwa, Joshodeep; Deb, Chandra; Chowdhury, Arnab Roy; Jeyaraj, Duraiswamy A.; Reddy, Ramana; Reddy, Premkumar; Maniar, Manoj; Bansal, Sachin; Gupta, Jang B.	Preclinical formulation for the pharmacokinetics and efficacy of GBO-006, a selective polo like kinase 2 (PLK2) inhibitor for the treatment of triple negative breast cancer	2016	13	.pdf	application/pdf	6089	290	61	Other pharmacokinetic variables, including the total plasma clearance (CL), steady-state volume of distribution (Vss), and oral bioavailability (%F) were also calculated. IV PO Dose (mg/kg) 2 5 CL (mL/min/Kg) 77 - thalf (h) 0.5 - Vdss (L/kg) 1.7 - MRT last (h) 0.4 - Cmax, PO (ng/mL) - 64 Tmax, PO (h) - 0.25 AUC0-24h (ng h /mL), IV/PO 431 25 Bioavailability (%F) 2 1 10 100 1.000 10.000 0 2 4 6 8 10 12 P la sm a C o cn e tr at io n (n g/ m L) Time (h) IV PO Srinivas Maddi et al.	cache/admet-341.pdf	txt/admet-341.txt