id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-373	Valko, Klara Livia; Teague, Simon P.; Pidgeon, Charles	In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery	2017	25	.pdf	application/pdf	10722	598	65	A balanced potency and chromatographically determined membrane and protein binding (IAM MB/PB) data enable selecting drug discovery compounds for further analysis that have the highest probability to show the desired in vivo distribution behavior for efficacy and reduced chance for toxicity. Recently, it was found that promiscuity (i.e., a discovery compound binding to multiple receptors) showed good correlation to the IAM MB of drug discovery compounds.	cache/admet-373.pdf	txt/admet-373.txt