id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-40	Koumandrakis, Nikolaos; Vertzoni, Maria; Reppas, Christos	Increasing the biorelevance of simulated intestinal fluids for better predictions of drug equilibrium solubility in the fasted upper small intestine	2014	9	.pdf	application/pdf	3833	173	57	This is in line with previous data indicating that luminal proteins may not be important to luminal drug solubility or their global simulation should be done cautiously [3]. In case the active pharmaceutical ingredient (API) is lipophilic, luminal colloidal species (e.g. mixed bile salt micelles) greatly enhance luminal solubility and relevant information is crucial for predictions of drug plasma levels after oral administration of conventional dosage forms, e.g. when physiologically based pharmacokinetic modelling approaches are applied [1].	cache/admet-40.pdf	txt/admet-40.txt