id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-437	Balakrishna, Vinod Anera; Police, Anitha; Hiremath, Rakesh; Raj, Anusha; Sulochana, Suresh P; Chandrasekhar, Devaraj V; Mohd, Zainuddin; Bhamidipati, Ravi Kanth; Mullangi, Ramesh	Preclinical assessment of ulixertinib, a novel ERK1/2 inhibitor	2017	12	.pdf	application/pdf	6033	288	52	However in dogs the oral bioavailability was 34 % and this may be due to high unbound concentrations (fu 0.05 in dog plasma vs 0.001 and 0.003 in mice and rat plasma, respectively) in plasma and extensive metabolism in dogs thus ulixertinib had relatively high plasma clearance. In rats also post oral administration early Tmax of 0.75 h suggesting that ulixertinib has a rapid absorption from gastrointestinal tract.	cache/admet-437.pdf	txt/admet-437.txt