id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-44	Cabot, Joan Marc; Subirats, Xavier; Fuguet, Elisabet; Rosés, Martí	High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods	2014	9	.pdf	application/pdf	4311	183	57	MeCN % MeCN 0.0 min -> 0% 0.0 min -> 0% 0.5 min -> 0% 0.4 min -> 0% 3.0 min -> 100% 2.5 min -> 100% 3.5 min -> 100% 2.9 min -> 100% 3.7 min -> 0% 3.1 min -> 0% 4.5 min -> 0% 3.8 min -> 0% Injection volume and solvent 3 μL - MeCN/aqueous buffer 0.2 μL - DMSO Similarly to log Do/w scale, CHI values of acidic or basic compounds depend on the ionization degree. ADMET & DMPK 2(2) (2014) 98-106 High throughput determination of log Do/w doi: 10.5599/admet.2.2.44 101 Results and Discussion Measurement of CHIMeCN values by UHPLC The HPLC fast gradient method developed by Valkó and co-workers [3] was transferred to our UHPLC system taking into consideration the column and particle sizes, the flow rate, the injection volume, and the dwell time of the UHPLC instrument.	cache/admet-44.pdf	txt/admet-44.txt