id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-505	Avdeef, Alex	Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments	2018	35	.pdf	application/pdf	15311	862	65	Conclusion The main objective of the study was to apply simulation methods to represent drug-micelle equilibrium reactions (based on the mass action paradigm), so as to optimize the design of experimental approaches used to assess drug solubility as a function of pH and the amount of added sodium dodecyl sulfate, particularly when applied to cocrystal formulations. A compilation of 101 published SDS k values of mostly poorly-soluble drug molecules was used to develop a prediction model as a function of the drug’s intrinsic solubility, S0, and its calculated H-bond acceptor/donor potential.	cache/admet-505.pdf	txt/admet-505.txt