id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-661	Vasoya, Jaydip M.; Shah, Ankita V.; Serajuddin, Abu T.M.	Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH	2019	24	.pdf	application/pdf	12459	508	47	When excess amounts of fumaric acid and succinic acid cocrystals were dissolved in water, pH values of the saturated solutions were, respectively, 4.1 and 4.2, and the solubilities of cocrystals were, respectively, 2.6 and 1.5 mg/mL (as ketoconazole equivalents). Since pHh=0 values for fumaric acid and succinic acid cocrystals at this pH were, respectively, 4.53 and 4.67, where the drug solubility is expected to be much higher than that at the pHh=0 of free base (pH 7.05), it is expected that dissolution rates of cocrystals at pH 7 would also be much higher than that of the free base.	cache/admet-661.pdf	txt/admet-661.txt