id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
admet-841	Abrami, Michela; Grassi, Lucia; Di Vittorio, Rosario; Hasa, Dritan; Perissutti, Beatrice; Voinovich, Dario; Grassi, Gabriele; Colombo, Italo; Grassi, Mario	Dissolution of an ensemble of differently shaped poly-dispersed drug particles undergoing solubility reduction: mathematical modelling	2020	17	.pdf	application/pdf	9698	487	57	Additionally, due to the relevance in the pharmaceutical field, theorists started considering also possible variation of solubility occurring upon dissolution, whose kinetics, as later discussed, essentially depends on the surface available for dissolution, on mass transport resistance occurring at, and around, the solid/liquid interface and on drug solubility in the liquid phase.  min min( )m sD C k C C         n (4) C(ξmax) = Cb (5) http://dx.doi.org/10.5599/admet.841 Mario Grassi et al. ADMET & DMPK 8(3) (2020) 297-313 300 where  is the one dimensional spatial coordinate, (max -min) is the thickness of the unstirred layer (), n is the surface normal versor, Cs is drug solubility in the dissolution liquid while km is the interface mass transfer coefficient mainly depending on the dissolution surface wetting properties and representing dissolution step 1.	cache/admet-841.pdf	txt/admet-841.txt