id sid eid entity type admet-144 1 1 10.5599 CARDINAL admet-144 1 2 1 CARDINAL admet-144 1 3 admet & ORG admet-144 1 4 3(1 CARDINAL admet-144 1 5 2015 CARDINAL admet-144 1 6 1 CARDINAL admet-144 1 7 10.5599 CARDINAL admet-144 1 8 issn PERSON admet-144 1 9 1848-7718 DATE admet-144 1 10 julia riede1,2 PERSON admet-144 1 11 kunze1 EVENT admet-144 1 12 jΓΆrg huwyler2 PERSON admet-144 1 13 poller1 PERSON admet-144 1 14 kenichi umehara1 PERSON admet-144 1 15 1 CARDINAL admet-144 1 16 novartis ORG admet-144 1 17 basel GPE admet-144 1 18 switzerland GPE admet-144 1 19 2 CARDINAL admet-144 1 20 university of basel ORG admet-144 1 21 basel GPE admet-144 1 22 switzerland GPE admet-144 2 1 +41-61 CARDINAL admet-144 2 2 november 14, 2014 DATE admet-144 2 3 december 18, 2015 DATE admet-144 2 4 march 31 DATE admet-144 2 5 2015 DATE admet-144 9 1 first ORDINAL admet-144 12 1 ecm ORG admet-144 12 2 1,2 CARDINAL admet-144 13 1 𝐢𝐿𝑖𝑛𝑑 𝑃𝑆𝑒𝑓𝑓 PERSON admet-144 14 1 𝑃𝑆𝑒𝑓𝑓 ORG admet-144 14 2 + 𝑃𝑆𝑒𝑓𝑓 GPE admet-144 14 3 + 𝐢𝐿𝑖𝑛𝑑 PERSON admet-144 14 4 1 CARDINAL admet-144 15 1 al. admet ORG admet-144 15 2 3(1 CARDINAL admet-144 15 3 2015 CARDINAL admet-144 15 4 1 CARDINAL admet-144 15 5 clint PERSON admet-144 15 6 sec ORG admet-144 15 7 clint PERSON admet-144 16 1 pseff PERSON admet-144 17 1 clint PERSON admet-144 17 2 clint ORG admet-144 17 3 sec ORG admet-144 17 4 clint PERSON admet-144 17 5 clint PERSON admet-144 18 1 1 CARDINAL admet-144 20 1 1 CARDINAL admet-144 20 2 four CARDINAL admet-144 21 1 1 CARDINAL admet-144 22 1 1 CARDINAL admet-144 22 2 ecm ORG admet-144 22 3 2 CARDINAL admet-144 23 1 3 CARDINAL admet-144 23 2 ecm ORG admet-144 23 3 4 CARDINAL admet-144 24 1 1 CARDINAL admet-144 24 2 ecm ORG admet-144 24 3 thyat pseff PERSON admet-144 24 4 zero CARDINAL admet-144 24 5 1 CARDINAL admet-144 28 1 𝑃𝑆𝑒𝑓𝑓 ORG admet-144 28 2 + 𝑃𝑆𝑒𝑓𝑓 GPE admet-144 28 3 + 𝐢𝐿𝑖𝑛𝑑 PERSON admet-144 28 4 2 CARDINAL admet-144 28 5 3(1 CARDINAL admet-144 28 6 2015 CARDINAL admet-144 28 7 1 CARDINAL admet-144 28 8 10.5599/admet.3.1.144 3 QUANTITY admet-144 28 9 20.7 CARDINAL admet-144 29 1 1,3 CARDINAL admet-144 30 1 clint PERSON admet-144 30 2 sec ORG admet-144 30 3 clint PERSON admet-144 30 4 hlm ORG admet-144 30 5 incubations PERSON admet-144 35 1 1 CARDINAL admet-144 36 1 2 CARDINAL admet-144 37 1 1 CARDINAL admet-144 37 2 19 CARDINAL admet-144 37 3 ecm ORG admet-144 37 4 fig ORG admet-144 38 1 1 CARDINAL admet-144 39 1 1 CARDINAL admet-144 39 2 4 CARDINAL admet-144 40 1 1 CARDINAL admet-144 42 1 ecm/ecc psinf ORG admet-144 42 2 pas clint PERSON admet-144 42 3 hlm clint PERSON admet-144 42 4 hh clint PERSON admet-144 42 5 sec ORG admet-144 42 6 obs fnren ORG admet-144 42 7 lovastatin ORG admet-144 42 8 3/1 CARDINAL admet-144 42 9 165.1 CARDINAL admet-144 42 10 145.5 CARDINAL admet-144 42 11 simvastatin ORG admet-144 42 12 3/1 CARDINAL admet-144 42 13 116.1 297.9 769.2 QUANTITY admet-144 43 1 0.13 0.87 CARDINAL admet-144 43 2 4/2 CARDINAL admet-144 43 3 300.7 CARDINAL admet-144 43 4 110.8 CARDINAL admet-144 43 5 29.2 CARDINAL admet-144 43 6 4/2 CARDINAL admet-144 43 7 229.4 109.3 QUANTITY admet-144 43 8 28.4 CARDINAL admet-144 43 9 18.0 CARDINAL admet-144 43 10 2/2 CARDINAL admet-144 43 11 127.7 CARDINAL admet-144 43 12 13.7 0.03 0.97 QUANTITY admet-144 43 13 2/2 CARDINAL admet-144 43 14 0.0 CARDINAL admet-144 43 15 1568.5 CARDINAL admet-144 43 16 29.6 0.02 CARDINAL admet-144 43 17 cerivastatin PERSON admet-144 43 18 4/2 CARDINAL admet-144 43 19 221.5 243.8 46.9 QUANTITY admet-144 43 20 0.0 0.02 CARDINAL admet-144 43 21 4/2 CARDINAL admet-144 43 22 325.5 CARDINAL admet-144 43 23 146.8 CARDINAL admet-144 43 24 0.0 0.04 7.0 0.00 1.00 pitavastatin QUANTITY admet-144 43 25 4/2 CARDINAL admet-144 43 26 364.3 258.7 17.7 QUANTITY admet-144 43 27 0.0 0.07 3.5 0.00 CARDINAL admet-144 43 28 3/3 CARDINAL admet-144 43 29 32.3 25.4 89.2 QUANTITY admet-144 43 30 31.2 CARDINAL admet-144 43 31 0.10 CARDINAL admet-144 43 32 3/3 CARDINAL admet-144 43 33 3/3 CARDINAL admet-144 43 34 18.4 0.82 CARDINAL admet-144 43 35 0.66 0.04 CARDINAL admet-144 43 36 3/4 CARDINAL admet-144 43 37 41.9 CARDINAL admet-144 43 38 13.5 CARDINAL admet-144 43 39 0.96 CARDINAL admet-144 43 40 4/4 CARDINAL admet-144 43 41 140.4 57.7 64.6 254.4 QUANTITY admet-144 43 42 5.9 0.02 0.69 CARDINAL admet-144 43 43 4/4 CARDINAL admet-144 43 44 0.4 0.66 0.01 CARDINAL admet-144 43 45 4/4 CARDINAL admet-144 43 46 7.0 22.9 22.0 QUANTITY admet-144 43 47 0.0 0.69 MONEY admet-144 43 48 4/4 CARDINAL admet-144 43 49 16.0 18.5 4.1 QUANTITY admet-144 43 50 21.5 0.09 0.6 0.29 0.11 QUANTITY admet-144 43 51 4/4 CARDINAL admet-144 43 52 57.9 36.0 QUANTITY admet-144 43 53 4/4 CARDINAL admet-144 43 54 24.8 1.5 CARDINAL admet-144 43 55 5.7 0.17 CARDINAL admet-144 43 56 4 CARDINAL admet-144 44 1 5,6 CARDINAL admet-144 44 2 1,4,7 CARDINAL admet-144 45 1 ecm PERSON admet-144 45 2 fig ORG admet-144 46 1 1 CARDINAL admet-144 47 1 6 CARDINAL admet-144 47 2 1 or 3 CARDINAL admet-144 47 3 clint ORG admet-144 47 4 hlm ORG admet-144 47 5 sec ORG admet-144 47 6 2 CARDINAL admet-144 49 1 fnren (= clren ORG admet-144 49 2 obs/cltot ORG admet-144 49 3 obs) ORG admet-144 50 1 fnh ORG admet-144 50 2 1fnren CARDINAL admet-144 51 1 al. admet ORG admet-144 51 2 3(1 CARDINAL admet-144 51 3 2015 CARDINAL admet-144 51 4 1 CARDINAL admet-144 52 1 1 CARDINAL admet-144 53 1 2 CARDINAL admet-144 54 1 2 CARDINAL admet-144 56 1 8 CARDINAL admet-144 58 1 2 CARDINAL admet-144 59 1 200 CARDINAL admet-144 61 1 2 CARDINAL admet-144 62 1 fig ORG admet-144 63 1 3 CARDINAL admet-144 65 1 3(1 CARDINAL admet-144 65 2 2015 CARDINAL admet-144 65 3 1 CARDINAL admet-144 65 4 10.5599 CARDINAL admet-144 65 5 5 CARDINAL admet-144 65 6 3 CARDINAL admet-144 65 7 1 CARDINAL admet-144 66 1 200 CARDINAL admet-144 67 1 2 CARDINAL admet-144 67 2 fnh ORG admet-144 68 1 40-60 CARDINAL admet-144 68 2 80 % PERCENT admet-144 69 1 4 CARDINAL admet-144 73 1 4 CARDINAL admet-144 73 2 40 CARDINAL admet-144 73 3 fnren GPE admet-144 73 4 20 % PERCENT admet-144 74 1 20% PERCENT admet-144 75 1 4 CARDINAL admet-144 76 1 obs = clh ORG admet-144 76 2 obs + clren ORG admet-144 76 3 1 CARDINAL admet-144 78 1 al. admet ORG admet-144 78 2 3(1 CARDINAL admet-144 78 3 2015 CARDINAL admet-144 78 4 1 CARDINAL admet-144 79 1 2 CARDINAL admet-144 79 2 fnren ORG admet-144 81 1 4 CARDINAL admet-144 82 1 100 CARDINAL admet-144 83 1 200 CARDINAL admet-144 83 2 100-200 QUANTITY admet-144 83 3 100 CARDINAL admet-144 83 4 5 CARDINAL admet-144 86 1 2 CARDINAL admet-144 87 1 between 30-60 CARDINAL admet-144 88 1 2 CARDINAL admet-144 88 2 around 30 ml/(minΒ·kg TIME admet-144 89 1 5 CARDINAL admet-144 90 1 fnmet ORG admet-144 90 2 fnren ORG admet-144 91 1 about 60 CARDINAL admet-144 93 1 1 CARDINAL admet-144 93 2 5 CARDINAL admet-144 95 1 6 CARDINAL admet-144 97 1 3(1 CARDINAL admet-144 97 2 2015 CARDINAL admet-144 97 3 1 CARDINAL admet-144 97 4 10.5599 CARDINAL admet-144 97 5 7 CARDINAL admet-144 98 1 1 CARDINAL admet-144 99 1 2 CARDINAL admet-144 100 1 60 CARDINAL admet-144 101 1 2 CARDINAL admet-144 102 1 5 CARDINAL admet-144 103 1 3-fold CARDINAL admet-144 103 2 β‰ˆ CARDINAL admet-144 105 1 19 CARDINAL admet-144 105 2 four CARDINAL admet-144 105 3 1 CARDINAL admet-144 106 1 6 CARDINAL admet-144 108 1 biopharmaceutics ORG admet-144 109 1 3 CARDINAL admet-144 109 2 1 and 2 CARDINAL admet-144 109 3 8 CARDINAL admet-144 110 1 biopharmaceutics ORG admet-144 110 2 four CARDINAL admet-144 113 1 6 CARDINAL admet-144 114 1 al. admet ORG admet-144 114 2 3(1 CARDINAL admet-144 114 3 2015 CARDINAL admet-144 114 4 1 CARDINAL admet-144 115 1 1 CARDINAL admet-144 116 1 2 CARDINAL admet-144 117 1 7 CARDINAL admet-144 118 1 11 CARDINAL admet-144 118 2 18 CARDINAL admet-144 118 3 two-fold CARDINAL admet-144 119 1 0.92 CARDINAL admet-144 119 2 1.55 CARDINAL admet-144 121 1 0.76 CARDINAL admet-144 121 2 2.11 CARDINAL admet-144 121 3 0.32 CARDINAL admet-144 121 4 gmfe = PERSON admet-144 121 5 3.56 CARDINAL admet-144 122 1 7 CARDINAL admet-144 122 2 1.71 CARDINAL admet-144 122 3 1.84 CARDINAL admet-144 123 1 7 CARDINAL admet-144 124 1 ecm ORG admet-144 125 1 hlm ORG admet-144 126 1 1 CARDINAL admet-144 126 2 2 DATE admet-144 126 3 3 CARDINAL admet-144 126 4 4 CARDINAL admet-144 126 5 1 CARDINAL admet-144 129 1 7 CARDINAL admet-144 132 1 1 CARDINAL admet-144 132 2 2 CARDINAL admet-144 132 3 3 CARDINAL admet-144 133 1 4 CARDINAL admet-144 134 1 3(1 CARDINAL admet-144 134 2 2015 CARDINAL admet-144 134 3 1 CARDINAL admet-144 134 4 10.5599 CARDINAL admet-144 134 5 9 CARDINAL admet-144 137 1 3 CARDINAL admet-144 137 2 4 CARDINAL admet-144 137 3 1 and 2 CARDINAL admet-144 139 1 8 CARDINAL admet-144 140 1 hlm ORG admet-144 140 2 ecm ORG admet-144 141 1 clint ORG admet-144 141 2 sec ORG admet-144 141 3 clint PERSON admet-144 144 1 1 CARDINAL admet-144 144 2 1,7 CARDINAL admet-144 144 3 1βˆ’ TIME admet-144 145 1 1βˆ’ TIME admet-144 145 2 1βˆ’ 𝑓𝑖 , TIME admet-144 146 1 1βˆ’ 𝑓𝑖 TIME admet-144 146 2 sec ORG admet-144 147 1 zero CARDINAL admet-144 147 2 one CARDINAL admet-144 147 3 3 CARDINAL admet-144 147 4 al. admet ORG admet-144 147 5 3(1 CARDINAL admet-144 147 6 2015 CARDINAL admet-144 147 7 1 CARDINAL admet-144 149 1 2 CARDINAL admet-144 152 1 1 CARDINAL admet-144 152 2 + 1βˆ’ π‘“π‘›β„Ž TIME admet-144 152 3 fh ORG admet-144 152 4 1-clh CARDINAL admet-144 152 5 fh ORG admet-144 152 6 1-clh CARDINAL admet-144 152 7 first ORDINAL admet-144 153 1 fnh ORG admet-144 153 2 1 CARDINAL admet-144 153 3 4 CARDINAL admet-144 153 4 𝑖𝑛𝑑 πΆπΏβ„Ž PERSON admet-144 153 5 5 CARDINAL admet-144 153 6 four CARDINAL admet-144 154 1 fig. DATE admet-144 155 1 9 CARDINAL admet-144 155 2 9 CARDINAL admet-144 155 3 5 CARDINAL admet-144 155 4 four CARDINAL admet-144 155 5 ecm ORG admet-144 157 1 fig PERSON admet-144 158 1 10 CARDINAL admet-144 158 2 3 CARDINAL admet-144 158 3 ecm ORG admet-144 158 4 2 CARDINAL admet-144 158 5 3 CARDINAL admet-144 158 6 ecm ORG admet-144 158 7 4 CARDINAL admet-144 159 1 4 CARDINAL admet-144 160 1 5 CARDINAL admet-144 160 2 90% PERCENT admet-144 160 3 4 CARDINAL admet-144 160 4 5 CARDINAL admet-144 160 5 3(1 CARDINAL admet-144 160 6 2015 CARDINAL admet-144 160 7 1 CARDINAL admet-144 160 8 10.5599 CARDINAL admet-144 160 9 11 CARDINAL admet-144 160 10 sec ORG admet-144 160 11 0.9 CARDINAL admet-144 161 1 10 CARDINAL admet-144 161 2 ecm ORG admet-144 161 3 2 CARDINAL admet-144 163 1 ecm ORG admet-144 163 2 3 CARDINAL admet-144 164 1 ecm ORG admet-144 164 2 4 CARDINAL admet-144 165 1 fnh ORG admet-144 166 1 4 CARDINAL admet-144 167 1 about 8-fold CARDINAL admet-144 168 1 10 CARDINAL admet-144 169 1 ecm ORG admet-144 170 1 four CARDINAL admet-144 171 1 1 CARDINAL admet-144 172 1 1 CARDINAL admet-144 173 1 10 CARDINAL admet-144 174 1 static victim drug ddi ORG admet-144 174 2 pravastatin PERSON admet-144 174 3 mrp2 GPE admet-144 174 4 oatp2b1 GPE admet-144 174 5 cyp3a4 NORP admet-144 175 1 5 CARDINAL admet-144 176 1 4 CARDINAL admet-144 177 1 sec ORG admet-144 177 2 0.9 CARDINAL admet-144 178 1 1 CARDINAL admet-144 180 1 4 CARDINAL admet-144 180 2 ecm class 1 and 2 ORG admet-144 181 1 fnren ORG admet-144 181 2 fnh ORG admet-144 181 3 3 CARDINAL admet-144 181 4 mrp2 GPE admet-144 181 5 cyp3a4 PERSON admet-144 181 6 ugt PERSON admet-144 181 7 about 20-fold CARDINAL admet-144 181 8 2.6-fold CARDINAL admet-144 181 9 10 CARDINAL admet-144 183 1 al. admet ORG admet-144 183 2 3(1 CARDINAL admet-144 183 3 2015 CARDINAL admet-144 183 4 1 CARDINAL admet-144 183 5 14 12 CARDINAL admet-144 185 1 5 CARDINAL admet-144 186 1 5 CARDINAL admet-144 186 2 10 CARDINAL admet-144 188 1 4 CARDINAL admet-144 189 1 5 CARDINAL admet-144 189 2 7 CARDINAL admet-144 190 1 11 CARDINAL admet-144 191 1 6 CARDINAL admet-144 192 1 1 CARDINAL admet-144 195 1 1 CARDINAL admet-144 195 2 11 CARDINAL admet-144 195 3 πΆβ„Ž NORP admet-144 196 1 + 𝐢𝐿𝑖𝑛𝑑 PERSON admet-144 196 2 6 CARDINAL admet-144 196 3 3(1 CARDINAL admet-144 196 4 2015 CARDINAL admet-144 196 5 1 CARDINAL admet-144 196 6 10.5599 CARDINAL admet-144 196 7 13 CARDINAL admet-144 197 1 ecm ORG admet-144 197 2 fig. DATE admet-144 198 1 11 CARDINAL admet-144 200 1 cb,u ORG admet-144 200 2 cb ORG admet-144 200 3 ki PERSON admet-144 203 1 2.4 CARDINAL admet-144 203 2 4 CARDINAL admet-144 203 3 about 80-fold CARDINAL admet-144 203 4 ecm PERSON admet-144 203 5 3 CARDINAL admet-144 205 1 1 CARDINAL admet-144 205 2 3 CARDINAL admet-144 205 3 4 CARDINAL admet-144 205 4 2 CARDINAL admet-144 205 5 2 CARDINAL admet-144 207 1 6 CARDINAL admet-144 207 2 cb ORG admet-144 207 3 1 CARDINAL admet-144 207 4 2 CARDINAL admet-144 207 5 u = cb PERSON admet-144 207 6 3 CARDINAL admet-144 207 7 cb ORG admet-144 207 8 4 CARDINAL admet-144 207 9 cb ORG admet-144 207 10 ecm ORG admet-144 210 1 ecm ORG admet-144 213 1 al. admet ORG admet-144 213 2 3(1 CARDINAL admet-144 213 3 2015 CARDINAL admet-144 213 4 1 CARDINAL admet-144 213 5 basel GPE admet-144 213 6 switzerland GPE admet-144 214 1 dr markus zollinger PERSON admet-144 215 1 1 CARDINAL admet-144 215 2 k. umehara, PERSON admet-144 215 3 biopharmaceutics & drug ORG admet-144 215 4 33 DATE admet-144 215 5 2012 DATE admet-144 215 6 179-1940 DATE admet-144 216 1 2 CARDINAL admet-144 216 2 h. sato PERSON admet-144 216 3 annual DATE admet-144 216 4 45 DATE admet-144 216 5 689723 DATE admet-144 217 1 3 CARDINAL admet-144 217 2 g. camenisch PERSON admet-144 217 3 29 CARDINAL admet-144 217 4 2012 DATE admet-144 217 5 603 CARDINAL admet-144 218 1 4 CARDINAL admet-144 218 2 a. kunze PERSON admet-144 218 3 b. poller PERSON admet-144 218 4 j. huwyler PERSON admet-144 218 5 g. camenisch PERSON admet-144 219 1 5 CARDINAL admet-144 219 2 d. mcginnity PERSON admet-144 219 3 m. soars PERSON admet-144 219 4 r. urbanowicz PERSON admet-144 219 5 r. riley PERSON admet-144 219 6 32 (2004 DATE admet-144 219 7 1247-1253 DATE admet-144 220 1 6 CARDINAL admet-144 220 2 e. turlizzi PERSON admet-144 220 3 zanelli PERSON admet-144 220 4 j. houston PERSON admet-144 220 5 european journal of pharmaceutical sciences ORG admet-144 220 6 45 DATE admet-144 220 7 2012 DATE admet-144 220 8 574 CARDINAL admet-144 221 1 7 CARDINAL admet-144 221 2 a. kunze PERSON admet-144 221 3 j. huwyler PERSON admet-144 221 4 b. poller PERSON admet-144 221 5 h. gutmann PERSON admet-144 221 6 g. camenisch PERSON admet-144 221 7 103 CARDINAL admet-144 221 8 2014 DATE admet-144 221 9 994 CARDINAL admet-144 222 1 8 CARDINAL admet-144 222 2 l. benet PERSON admet-144 222 3 g. amidon PERSON admet-144 222 4 d. barends PERSON admet-144 222 5 h. lennernas PERSON admet-144 222 6 j. polli PERSON admet-144 222 7 v. shah PERSON admet-144 222 8 s. stavchansky PERSON admet-144 222 9 l. yu PERSON admet-144 222 10 25 CARDINAL admet-144 222 11 483 CARDINAL admet-144 223 1 9 CARDINAL admet-144 223 2 m. chiba PERSON admet-144 223 3 11 CARDINAL admet-144 223 4 2009 DATE admet-144 223 5 262 CARDINAL admet-144 224 1 10 CARDINAL admet-144 224 2 h. rawden PERSON admet-144 224 3 n. hakooz PERSON admet-144 224 4 j. houston PERSON admet-144 224 5 33 (2005 DATE admet-144 224 6 1852-1858 DATE admet-144 225 1 11 CARDINAL admet-144 225 2 k. maeda PERSON admet-144 225 3 k. ikejiri PERSON admet-144 225 4 k. yoshida PERSON admet-144 225 5 t. horie PERSON admet-144 225 6 biopharmaceutics & drug ORG admet-144 225 7 34 CARDINAL admet-144 225 8 2013 DATE admet-144 225 9 45 CARDINAL admet-144 226 1 2015 DATE admet-144 226 2 iapc ORG admet-144 226 3 zagreb GPE admet-144 226 4 croatia GPE admet-144 227 1 http://creativecommons.org/licenses/by/3.0/ ORG admet-144 227 2 http://creativecommons.org/licenses/by/3.0/ ORG