id	sid	eid	entity	type
admet-337	1	1	10.5599	CARDINAL
admet-337	1	2	186	CARDINAL
admet-337	1	3	admet &	ORG
admet-337	1	4	4(3	CARDINAL
admet-337	1	5	2016	CARDINAL
admet-337	1	6	186	CARDINAL
admet-337	1	7	10.5599	CARDINAL
admet-337	1	8	issn	PERSON
admet-337	1	9	1848-7718	DATE
admet-337	1	10	jonathan r.thompson1	PERSON
admet-337	1	11	smitha p. menon2	PERSON
admet-337	2	1	1	CARDINAL
admet-337	2	2	willms &sue	ORG
admet-337	2	3	wisconsin	GPE
admet-337	2	4	milwaukee	GPE
admet-337	2	5	wi 2	ORG
admet-337	2	6	wisconsin	GPE
admet-337	2	7	milwaukee	GPE
admet-337	2	8	wi 3	ORG
admet-337	2	9	roswell park cancer	ORG
admet-337	2	10	buffalo	GPE
admet-337	2	11	ny	GPE
admet-337	3	1	august 15, 2016	DATE
admet-337	3	2	september 11, 2016	DATE
admet-337	3	3	september 30, 2016	DATE
admet-337	5	1	alk tkis	PERSON
admet-337	5	2	second	ORDINAL
admet-337	7	1	four	CARDINAL
admet-337	7	2	three	CARDINAL
admet-337	7	3	the united states food and drug	GPE
admet-337	7	4	fda	ORG
admet-337	8	1	1.6 million	CARDINAL
admet-337	8	2	annually	DATE
admet-337	8	3	1	CARDINAL
admet-337	9	1	85 %	PERCENT
admet-337	9	2	2	CARDINAL
admet-337	10	1	5-year	DATE
admet-337	10	2	less than 5 %	PERCENT
admet-337	10	3	3	CARDINAL
admet-337	11	1	the past decade	DATE
admet-337	13	1	30-40 %	PERCENT
admet-337	13	2	asian	NORP
admet-337	13	3	10 %	PERCENT
admet-337	13	4	caucasian	NORP
admet-337	13	5	4,5	CARDINAL
admet-337	15	1	3 to 7 %	PERCENT
admet-337	15	2	6	CARDINAL
admet-337	17	1	4(3	CARDINAL
admet-337	17	2	2016	CARDINAL
admet-337	17	3	186	CARDINAL
admet-337	17	4	10.5599	CARDINAL
admet-337	17	5	187	CARDINAL
admet-337	18	1	4 to 12 months	DATE
admet-337	19	1	7	CARDINAL
admet-337	19	2	egfror alk-mutated	PERSON
admet-337	19	3	3 to 4 years or	DATE
admet-337	19	4	11-15	CARDINAL
admet-337	20	1	four	CARDINAL
admet-337	20	2	three	CARDINAL
admet-337	21	1	first	ORDINAL
admet-337	22	1	afatinib	PERSON
admet-337	22	2	second	ORDINAL
admet-337	23	1	third	ORDINAL
admet-337	24	1	crizotinib	PERSON
admet-337	24	2	first	ORDINAL
admet-337	24	3	ceritinib	NORP
admet-337	25	1	alk mutations	PERSON
admet-337	28	1	egf	ORG
admet-337	28	2	tgf-α	ORG
admet-337	29	1	16,17	CARDINAL
admet-337	32	1	the ras/raf/mek/erk	ORG
admet-337	32	2	3	CARDINAL
admet-337	32	3	janus kinase	PERSON
admet-337	33	1	2004	DATE
admet-337	33	2	asian	NORP
admet-337	35	1	7	CARDINAL
admet-337	35	2	18 to 22	CARDINAL
admet-337	36	1	90 %	PERCENT
admet-337	36	2	19	CARDINAL
admet-337	36	3	21	CARDINAL
admet-337	37	1	22	CARDINAL
admet-337	39	1	fda	ORG
admet-337	39	2	egfr tkis	ORG
admet-337	39	3	1	CARDINAL
admet-337	40	1	fda	ORG
admet-337	40	2	november 2004	DATE
admet-337	40	3	second	ORDINAL
admet-337	41	1	2.2 months	DATE
admet-337	41	2	1.8 months	DATE
admet-337	41	3	6.7 months	DATE
admet-337	41	4	4.7 months	DATE
admet-337	41	5	0.71	CARDINAL
admet-337	41	6	25	CARDINAL
admet-337	42	1	fda	ORG
admet-337	42	2	april 2010	DATE
admet-337	42	3	four	CARDINAL
admet-337	43	1	al. admet	ORG
admet-337	43	2	4(3	CARDINAL
admet-337	43	3	2016	CARDINAL
admet-337	43	4	186	CARDINAL
admet-337	43	5	211 188	CARDINAL
admet-337	43	6	889	CARDINAL
admet-337	43	7	first	ORDINAL
admet-337	43	8	12.3 weeks	DATE
admet-337	43	9	11.1 weeks	DATE
admet-337	43	10	0.71	CARDINAL
admet-337	43	11	12 months	DATE
admet-337	43	12	11.1 months	DATE
admet-337	43	13	0.81	CARDINAL
admet-337	44	1	26	CARDINAL
admet-337	45	1	1	CARDINAL
admet-337	45	2	egfr tki	ORG
admet-337	45	3	19	CARDINAL
admet-337	45	4	19	CARDINAL
admet-337	45	5	19 l858r t790	QUANTITY
admet-337	45	6	19 l858r	QUANTITY
admet-337	45	7	first	ORDINAL
admet-337	45	8	first	ORDINAL
admet-337	45	9	first	ORDINAL
admet-337	45	10	second	ORDINAL
admet-337	45	11	ic50	ORG
admet-337	45	12	23	CARDINAL
admet-337	45	13	39	CARDINAL
admet-337	45	14	30	DATE
admet-337	45	15	100	CARDINAL
admet-337	45	16	0.2	CARDINAL
admet-337	45	17	0.2	CARDINAL
admet-337	45	18	9	CARDINAL
admet-337	45	19	12	CARDINAL
admet-337	45	20	ic50	PERSON
admet-337	46	1	22,24	CARDINAL
admet-337	46	2	1600	CARDINAL
admet-337	46	3	10000	CARDINAL
admet-337	46	4	5000	CARDINAL
admet-337	46	5	141	CARDINAL
admet-337	46	6	196	CARDINAL
admet-337	46	7	3	CARDINAL
admet-337	46	8	13	CARDINAL
admet-337	46	9	cyp3a4 & cyp2d6	ORG
admet-337	50	1	michael	PERSON
admet-337	50	2	83 %	PERCENT
admet-337	50	3	1 %	PERCENT
admet-337	50	4	8 %	PERCENT
admet-337	50	5	86%	PERCENT
admet-337	50	6	4%	PERCENT
admet-337	50	7	85%	PERCENT
admet-337	50	8	89%	PERCENT
admet-337	50	9	4%	PERCENT
admet-337	50	10	68 %	PERCENT
admet-337	50	11	2 %	PERCENT
admet-337	50	12	14 %	PERCENT
admet-337	51	1	1	CARDINAL
admet-337	51	2	0.2-1 %	PERCENT
admet-337	52	1	first	ORDINAL
admet-337	54	1	50 %	PERCENT
admet-337	54	2	first	ORDINAL
admet-337	54	3	19	CARDINAL
admet-337	54	4	may 2013	DATE
admet-337	55	1	3	CARDINAL
admet-337	55	2	9.7 months	DATE
admet-337	55	3	5.2 months	DATE
admet-337	55	4	0.37	CARDINAL
admet-337	55	5	4(3	CARDINAL
admet-337	55	6	2016	CARDINAL
admet-337	55	7	186	CARDINAL
admet-337	55	8	10.5599	CARDINAL
admet-337	55	9	189	CARDINAL
admet-337	55	10	first	ORDINAL
admet-337	56	1	27	CARDINAL
admet-337	57	1	first	ORDINAL
admet-337	59	1	61 to 80 %	PERCENT
admet-337	59	2	3	CARDINAL
admet-337	59	3	4	CARDINAL
admet-337	59	4	2 to 13 %	PERCENT
admet-337	61	1	the first 2 weeks	DATE
admet-337	61	2	as late as 2 months	DATE
admet-337	61	3	30	CARDINAL
admet-337	63	1	ten	CARDINAL
admet-337	65	1	21 to 57 %	PERCENT
admet-337	65	2	3	CARDINAL
admet-337	65	3	4	CARDINAL
admet-337	65	4	1-6 %	PERCENT
admet-337	66	1	5 %	PERCENT
admet-337	68	1	19 to 21 %	PERCENT
admet-337	68	2	7-12 %	PERCENT
admet-337	68	3	5-7 %	PERCENT
admet-337	68	4	27 %	PERCENT
admet-337	68	5	14 %	PERCENT
admet-337	68	6	6 %	PERCENT
admet-337	69	1	only 3 to	CARDINAL
admet-337	69	2	11,25,27,28	CARDINAL
admet-337	70	1	6	CARDINAL
admet-337	70	2	7	CARDINAL
admet-337	70	3	cp-358774	ORG
admet-337	70	4	osi	ORG
admet-337	70	5	genentech	ORG
admet-337	71	1	ic50	ORG
admet-337	71	2	2	CARDINAL
admet-337	71	3	ic50	ORG
admet-337	71	4	20	CARDINAL
admet-337	72	1	31	CARDINAL
admet-337	72	2	gak	ORG
admet-337	72	3	slk	ORG
admet-337	72	4	10	CARDINAL
admet-337	73	1	32	CARDINAL
admet-337	74	1	150	CARDINAL
admet-337	74	2	daily	DATE
admet-337	75	1	approximately 4 hours	TIME
admet-337	75	2	232	CARDINAL
admet-337	76	1	33	CARDINAL
admet-337	77	1	60 %	PERCENT
admet-337	77	2	nearly 100 %	PERCENT
admet-337	77	3	34	CARDINAL
admet-337	78	1	at least 1 hour	TIME
admet-337	78	2	at least 2 hours	TIME
admet-337	78	3	35	CARDINAL
admet-337	79	1	van leeuwen et al	PERSON
admet-337	79	2	tki drug-drug interactions	ORG
admet-337	79	3	170	CARDINAL
admet-337	83	1	46 %	PERCENT
admet-337	83	2	61 %	PERCENT
admet-337	85	1	36	CARDINAL
admet-337	86	1	93-95 %	PERCENT
admet-337	86	2	half	CARDINAL
admet-337	86	3	36 hours	TIME
admet-337	87	1	37	CARDINAL
admet-337	88	1	33	CARDINAL
admet-337	90	1	al. admet	ORG
admet-337	90	2	4(3	CARDINAL
admet-337	90	3	2016	CARDINAL
admet-337	90	4	186	CARDINAL
admet-337	90	5	cyp3a4	NORP
admet-337	91	1	24 %	PERCENT
admet-337	91	2	37	CARDINAL
admet-337	93	1	38	CARDINAL
admet-337	94	1	39	CARDINAL
admet-337	95	1	abcg2	PERSON
admet-337	96	1	40	CARDINAL
admet-337	98	1	43	CARDINAL
admet-337	99	1	83 %	PERCENT
admet-337	99	2	less than 2 %	PERCENT
admet-337	99	3	44	CARDINAL
admet-337	100	1	45	CARDINAL
admet-337	102	1	bbb	ORG
admet-337	103	1	bbb	ORG
admet-337	104	1	42	CARDINAL
admet-337	105	1	54 ng	QUANTITY
admet-337	106	1	5.1 %	PERCENT
admet-337	107	1	46	CARDINAL
admet-337	108	1	23	CARDINAL
admet-337	108	2	korean	NORP
admet-337	108	3	150 mg	QUANTITY
admet-337	108	4	daily	DATE
admet-337	108	5	250	CARDINAL
admet-337	108	6	69.6 %	PERCENT
admet-337	108	7	82.6 %	PERCENT
admet-337	108	8	47	CARDINAL
admet-337	109	1	600 mg	QUANTITY
admet-337	109	2	4 days	DATE
admet-337	109	3	300 mg	QUANTITY
admet-337	110	1	2	CARDINAL
admet-337	110	2	46,48,49	CARDINAL
admet-337	112	1	9	CARDINAL
admet-337	112	2	1500	CARDINAL
admet-337	112	3	weekly	DATE
admet-337	113	1	67 %	PERCENT
admet-337	113	2	2.7 months	DATE
admet-337	113	3	12 months	DATE
admet-337	113	4	50	CARDINAL
admet-337	114	1	20	CARDINAL
admet-337	114	2	790	CARDINAL
admet-337	114	3	egfr	PRODUCT
admet-337	115	1	approximately 50 %	PERCENT
admet-337	115	2	51,52	CARDINAL
admet-337	116	1	790	CARDINAL
admet-337	117	1	53	CARDINAL
admet-337	119	1	l858r	PERSON
admet-337	119	2	l858r 148 µm	PERSON
admet-337	119	3	5.9 µm	DATE
admet-337	119	4	5.2	CARDINAL
admet-337	120	1	egfr atp	ORG
admet-337	120	2	atp	ORG
admet-337	121	1	51	CARDINAL
admet-337	122	1	4(3	CARDINAL
admet-337	122	2	2016	CARDINAL
admet-337	122	3	186	CARDINAL
admet-337	122	4	10.5599	CARDINAL
admet-337	122	5	191	CARDINAL
admet-337	122	6	54	CARDINAL
admet-337	123	1	55	CARDINAL
admet-337	124	1	first	ORDINAL
admet-337	124	2	fda	ORG
admet-337	124	3	may 2003	DATE
admet-337	125	1	56	CARDINAL
admet-337	126	1	216	CARDINAL
admet-337	126	2	250 mg	QUANTITY
admet-337	126	3	500 mg	QUANTITY
admet-337	127	1	12 %	PERCENT
admet-337	127	2	250 mg	QUANTITY
admet-337	127	3	9 %	PERCENT
admet-337	127	4	1 year	DATE
admet-337	127	5	25 %	PERCENT
admet-337	127	6	57	CARDINAL
admet-337	130	1	september 2011	DATE
admet-337	130	2	fda	ORG
admet-337	130	3	astrazeneca	ORG
admet-337	130	4	us	GPE
admet-337	131	1	asian	NORP
admet-337	131	2	first	ORDINAL
admet-337	131	3	19	CARDINAL
admet-337	131	4	l858r mutations	PERSON
admet-337	132	1	3 to 5 months	DATE
admet-337	133	1	5861	DATE
admet-337	134	1	the united states	GPE
admet-337	135	1	july 2015	DATE
admet-337	135	2	fda	ORG
admet-337	135	3	first	ORDINAL
admet-337	135	4	19	CARDINAL
admet-337	135	5	l858r egfr	PERSON
admet-337	136	1	first	ORDINAL
admet-337	136	2	caucasian	NORP
admet-337	136	3	19	CARDINAL
admet-337	136	4	l858r egfr	PERSON
admet-337	137	1	106	CARDINAL
admet-337	137	2	69.8 %	PERCENT
admet-337	137	3	9.7 months	DATE
admet-337	137	4	19.2 months	DATE
admet-337	137	5	5	CARDINAL
admet-337	140	1	250	CARDINAL
admet-337	140	2	only 33 %	PERCENT
admet-337	140	3	150	CARDINAL
admet-337	140	4	daily	DATE
admet-337	141	1	250	CARDINAL
admet-337	141	2	500	CARDINAL
admet-337	142	1	62].for	CARDINAL
admet-337	142	2	44 to 77 %	PERCENT
admet-337	142	3	3	CARDINAL
admet-337	142	4	5	CARDINAL
admet-337	142	5	5 %	PERCENT
admet-337	143	1	ten	CARDINAL
admet-337	144	1	32-47 %	PERCENT
admet-337	144	2	3-5	CARDINAL
admet-337	144	3	1-4 %	PERCENT
admet-337	145	1	3	CARDINAL
admet-337	145	2	4	CARDINAL
admet-337	145	3	up to 11 %	PERCENT
admet-337	146	1	59,60,63,64	CARDINAL
admet-337	147	1	4	CARDINAL
admet-337	148	1	atp	PERSON
admet-337	149	1	250 mg	QUANTITY
admet-337	149	2	daily	DATE
admet-337	150	1	ic50	ORG
admet-337	150	2	0.03-0.1µm	MONEY
admet-337	150	3	egf	ORG
admet-337	150	4	ic50	ORG
admet-337	151	1	56	CARDINAL
admet-337	152	1	al. admet	ORG
admet-337	152	2	4(3	CARDINAL
admet-337	152	3	2016	CARDINAL
admet-337	152	4	186	CARDINAL
admet-337	152	5	211 192	CARDINAL
admet-337	152	6	between 3 and 7 hours	CARDINAL
admet-337	152	7	approximately 60 %	PERCENT
admet-337	153	1	65,66	CARDINAL
admet-337	154	1	66	CARDINAL
admet-337	156	1	90 %	PERCENT
admet-337	156	2	about 1700	CARDINAL
admet-337	157	1	67	CARDINAL
admet-337	159	1	68	CARDINAL
admet-337	161	1	69	CARDINAL
admet-337	162	1	only 4 %	PERCENT
admet-337	163	1	bbb	ORG
admet-337	164	1	8	CARDINAL
admet-337	164	2	3.7+/1.9 ng	QUANTITY
admet-337	164	3	1.13+/-0.36 %	PERCENT
admet-337	165	1	only 1 %	PERCENT
admet-337	165	2	one	CARDINAL
admet-337	166	1	70	CARDINAL
admet-337	168	1	1000 mg	QUANTITY
admet-337	168	2	daily	DATE
admet-337	171	1	71	CARDINAL
admet-337	172	1	52,72	CARDINAL
admet-337	173	1	18	CARDINAL
admet-337	173	2	4 (	PERCENT
admet-337	173	3	22 %	PERCENT
admet-337	174	1	erbb3	GPE
admet-337	175	1	about half	CARDINAL
admet-337	175	2	54,73	CARDINAL
admet-337	176	1	afatinib	PERSON
admet-337	176	2	first	ORDINAL
admet-337	177	1	fda	ORG
admet-337	177	2	july 2013	DATE
admet-337	177	3	first	ORDINAL
admet-337	177	4	19	CARDINAL
admet-337	177	5	l858r	PERSON
admet-337	178	1	3	CARDINAL
admet-337	179	1	345	CARDINAL
admet-337	180	1	56 %	PERCENT
admet-337	180	2	23 %	PERCENT
admet-337	181	1	13.6 months	DATE
admet-337	181	2	6.9 months	DATE
admet-337	181	3	0.47	CARDINAL
admet-337	181	4	95 %	PERCENT
admet-337	181	5	0.34	CARDINAL
admet-337	181	6	0.65	CARDINAL
admet-337	182	1	asian	NORP
admet-337	182	2	non-asian	NORP
admet-337	182	3	non-asian	NORP
admet-337	183	1	74	CARDINAL
admet-337	184	1	6	CARDINAL
admet-337	184	2	first	ORDINAL
admet-337	184	3	afatinib versus cisplatin	PERSON
admet-337	184	4	asian	NORP
admet-337	184	5	75	CARDINAL
admet-337	185	1	6	CARDINAL
admet-337	185	2	19	CARDINAL
admet-337	185	3	l858r	PERSON
admet-337	185	4	76	CARDINAL
admet-337	186	1	iib lux-lung 7	PERSON
admet-337	186	2	first	ORDINAL
admet-337	186	3	gefitinib admet &	ORG
admet-337	186	4	4(3	CARDINAL
admet-337	186	5	2016	CARDINAL
admet-337	186	6	186	CARDINAL
admet-337	186	7	10.5599	CARDINAL
admet-337	186	8	193	CARDINAL
admet-337	186	9	12	CARDINAL
admet-337	186	10	18	DATE
admet-337	186	11	24 months	DATE
admet-337	187	1	77	CARDINAL
admet-337	188	1	afatinib	PERSON
admet-337	188	2	fda	ORG
admet-337	188	3	april 2016	DATE
admet-337	188	4	second	ORDINAL
admet-337	189	1	afatinib	PERSON
admet-337	190	1	8 %	PERCENT
admet-337	190	2	79	CARDINAL
admet-337	191	1	afatinib	PERSON
admet-337	192	1	32 % and 25 %	PERCENT
admet-337	192	2	80	CARDINAL
admet-337	194	1	as high as	CARDINAL
admet-337	194	2	95 %	PERCENT
admet-337	194	3	3	CARDINAL
admet-337	194	4	14 %	PERCENT
admet-337	195	1	89 %	PERCENT
admet-337	195	2	3-5	CARDINAL
admet-337	195	3	16 %	PERCENT
admet-337	195	4	51-72 %	PERCENT
admet-337	195	5	3-5	CARDINAL
admet-337	195	6	8 %	PERCENT
admet-337	197	1	afatinib	PERSON
admet-337	198	1	2992	DATE
admet-337	198	2	boehringer ingelheim	ORG
admet-337	198	3	erbb1	EVENT
admet-337	198	4	erbb4	PERSON
admet-337	199	1	first	ORDINAL
admet-337	200	1	her2	PERSON
admet-337	200	2	erbb4	DATE
admet-337	201	1	81	CARDINAL
admet-337	202	1	afatinib	PERSON
admet-337	202	2	ic50	ORG
admet-337	202	3	l858r	PERSON
admet-337	202	4	100	CARDINAL
admet-337	203	1	80	CARDINAL
admet-337	204	1	afatinib	PERSON
admet-337	205	1	pi3k	PERSON
admet-337	206	1	her2	PERSON
admet-337	208	1	82	CARDINAL
admet-337	209	1	afatinib	PERSON
admet-337	209	2	40 mg	QUANTITY
admet-337	209	3	daily	DATE
admet-337	209	4	2 to 5 hours later	TIME
admet-337	212	1	92 %	PERCENT
admet-337	212	2	half	CARDINAL
admet-337	212	3	37 hours	TIME
admet-337	212	4	83	CARDINAL
admet-337	213	1	afatinib	PERSON
admet-337	214	1	michael	PERSON
admet-337	215	1	89 %	PERCENT
admet-337	215	2	85 %	PERCENT
admet-337	215	3	4 %	PERCENT
admet-337	216	1	84	CARDINAL
admet-337	217	1	afatinib	PERSON
admet-337	219	1	6-12 hours	QUANTITY
admet-337	219	2	85	CARDINAL
admet-337	220	1	15-29 ml/minute/1.73 m2	QUANTITY
admet-337	220	2	30	CARDINAL
admet-337	221	1	canadian	NORP
admet-337	224	1	canadian	NORP
admet-337	224	2	al. admet	ORG
admet-337	224	3	4(3	CARDINAL
admet-337	224	4	2016	CARDINAL
admet-337	224	5	186	CARDINAL
admet-337	226	1	3	CARDINAL
admet-337	226	2	35	CARDINAL
admet-337	226	3	first	ORDINAL
admet-337	227	1	11.1 months	DATE
admet-337	227	2	5.4 months	DATE
admet-337	227	3	0.52	CARDINAL
admet-337	228	1	541	CARDINAL
admet-337	228	2	100	CARDINAL
admet-337	228	3	74 %	PERCENT
admet-337	229	1	thirty-five percent	PERCENT
admet-337	229	2	120 days	DATE
admet-337	230	1	one	CARDINAL
admet-337	230	2	40 mg	QUANTITY
admet-337	230	3	about 1	CARDINAL
admet-337	230	4	86	CARDINAL
admet-337	231	1	42	CARDINAL
admet-337	232	1	47.6 %	PERCENT
admet-337	233	1	first	ORDINAL
admet-337	234	1	her2	PERSON
admet-337	234	2	kras	GPE
admet-337	234	3	nras	GPE
admet-337	234	4	jak2	ORG
admet-337	234	5	lbk1	ORG
admet-337	234	6	87	CARDINAL
admet-337	235	1	stat3	ORG
admet-337	235	2	fgfr1	ORG
admet-337	236	1	88-90	CARDINAL
admet-337	237	1	first	ORDINAL
admet-337	237	2	third	ORDINAL
admet-337	238	1	third	ORDINAL
admet-337	238	2	19	CARDINAL
admet-337	238	3	l858r	PERSON
admet-337	239	1	l858r	PERSON
admet-337	239	2	91	CARDINAL
admet-337	240	1	253	CARDINAL
admet-337	241	1	127	CARDINAL
admet-337	241	2	50.2 %	PERCENT
admet-337	243	1	51 %	PERCENT
admet-337	244	1	61 %	PERCENT
admet-337	244	2	only 21 %	PERCENT
admet-337	245	1	9.6 months	DATE
admet-337	245	2	2.8 months	DATE
admet-337	245	3	12	CARDINAL
admet-337	246	1	201	CARDINAL
admet-337	246	2	58 %	PERCENT
admet-337	247	1	aura2	PERSON
admet-337	247	2	64 %	PERCENT
admet-337	248	1	92	CARDINAL
admet-337	249	1	november 2015	DATE
admet-337	249	2	fda	ORG
admet-337	249	3	osimertinib	PERSON
admet-337	251	1	42 %	PERCENT
admet-337	251	2	only 1 %	PERCENT
admet-337	251	3	3	CARDINAL
admet-337	251	4	4	CARDINAL
admet-337	252	1	41 %	PERCENT
admet-337	252	2	only 0.5 %	PERCENT
admet-337	252	3	3	CARDINAL
admet-337	252	4	4	CARDINAL
admet-337	253	1	only 4 %	PERCENT
admet-337	254	1	2.2 %	PERCENT
admet-337	255	1	4(3	CARDINAL
admet-337	255	2	2016	CARDINAL
admet-337	255	3	186	CARDINAL
admet-337	255	4	10.5599	CARDINAL
admet-337	255	5	195	CARDINAL
admet-337	255	6	1 %	PERCENT
admet-337	257	1	10 %	PERCENT
admet-337	258	1	5.6 %	PERCENT
admet-337	258	2	12,92,93	CARDINAL
admet-337	259	1	n-[2-[2-(dimethylamino)ethyl-methylamino]-4	NORP
admet-337	260	1	azd-9291	DATE
admet-337	262	1	nearly 200-fold	CARDINAL
admet-337	262	2	l858r	PERSON
admet-337	262	3	91	CARDINAL
admet-337	263	1	osimertinib	ORG
admet-337	263	2	her4	GPE
admet-337	263	3	ack1	GPE
admet-337	263	4	94	CARDINAL
admet-337	264	1	80 mg	QUANTITY
admet-337	264	2	daily	DATE
admet-337	266	1	about 14 %	PERCENT
admet-337	266	2	95	CARDINAL
admet-337	267	1	approximately 6 hours	TIME
admet-337	267	2	986	CARDINAL
admet-337	267	3	half	CARDINAL
admet-337	267	4	48 hours	TIME
admet-337	270	1	two	CARDINAL
admet-337	270	2	az7550 and az5104	WORK_OF_ART
admet-337	270	3	91	CARDINAL
admet-337	273	1	osimertinib	PERSON
admet-337	273	2	68 %	PERCENT
admet-337	273	3	14 %	PERCENT
admet-337	273	4	only 2 %	PERCENT
admet-337	274	1	30 ml/min	QUANTITY
admet-337	275	1	94	CARDINAL
admet-337	276	1	10	CARDINAL
admet-337	277	1	aura2	GPE
admet-337	277	2	two	CARDINAL
admet-337	277	3	0.2 and 1 %	PERCENT
admet-337	277	4	94	CARDINAL
admet-337	278	1	two	CARDINAL
admet-337	278	2	80 mg	TIME
admet-337	278	3	daily	DATE
admet-337	278	4	96	CARDINAL
admet-337	279	1	160	CARDINAL
admet-337	279	2	daily	DATE
admet-337	281	1	12	CARDINAL
admet-337	281	2	12-week	DATE
admet-337	281	3	7	CARDINAL
admet-337	281	4	58.3 %	PERCENT
admet-337	281	5	2	CARDINAL
admet-337	281	6	16.7 %	PERCENT
admet-337	281	7	3	CARDINAL
admet-337	282	1	5	CARDINAL
admet-337	282	2	20	CARDINAL
admet-337	282	3	only 2	CARDINAL
admet-337	282	4	80	CARDINAL
admet-337	282	5	daily	DATE
admet-337	283	1	3	CARDINAL
admet-337	283	2	one	CARDINAL
admet-337	283	3	3 days	DATE
admet-337	283	4	80 mg	QUANTITY
admet-337	284	1	97	CARDINAL
admet-337	285	1	797	CARDINAL
admet-337	286	1	98	CARDINAL
admet-337	287	1	c797s	ORG
admet-337	287	2	up to 40 %	PERCENT
admet-337	287	3	99	CARDINAL
admet-337	288	1	al. admet	ORG
admet-337	288	2	4(3	CARDINAL
admet-337	288	3	2016	CARDINAL
admet-337	288	4	186	CARDINAL
admet-337	288	5	211 196	CARDINAL
admet-337	288	6	99	CARDINAL
admet-337	289	1	pc9	GPE
admet-337	289	2	nci	ORG
admet-337	289	3	nras	ORG
admet-337	289	4	kras	ORG
admet-337	290	1	mek	ORG
admet-337	290	2	100	CARDINAL
admet-337	291	1	2	CARDINAL
admet-337	291	2	third	ORDINAL
admet-337	291	3	1482694	DATE
admet-337	291	4	fda	ORG
admet-337	291	5	december 2015	DATE
admet-337	293	1	i/ii hm-emsi-101	EVENT
admet-337	294	1	june 2016	DATE
admet-337	294	2	76	CARDINAL
admet-337	294	3	daily	DATE
admet-337	295	1	62 %	PERCENT
admet-337	295	2	91 %	PERCENT
admet-337	296	1	3	CARDINAL
admet-337	296	2	4	CARDINAL
admet-337	296	3	5 %	PERCENT
admet-337	296	4	3	CARDINAL
admet-337	296	5	4	CARDINAL
admet-337	296	6	101	CARDINAL
admet-337	297	1	1	CARDINAL
admet-337	297	2	first	ORDINAL
admet-337	298	1	102	CARDINAL
admet-337	299	1	second	ORDINAL
admet-337	299	2	first	ORDINAL
admet-337	300	1	pembrolizumab	PERSON
admet-337	300	2	bevacizumab	PERSON
admet-337	300	3	afatinib	PERSON
admet-337	300	4	bi836845	PERSON
admet-337	301	1	2	CARDINAL
admet-337	301	2	egfr tkis	ORG
admet-337	302	1	102	CARDINAL
admet-337	302	2	i/ii	EVENT
admet-337	302	3	62%	PERCENT
admet-337	302	4	91%	PERCENT
admet-337	302	5	ii eluxa 1	ORG
admet-337	302	6	2	CARDINAL
admet-337	302	7	1	CARDINAL
admet-337	302	8	pembrolizumab	PERSON
admet-337	302	9	bevacizumab	PERSON
admet-337	302	10	afatinib	PERSON
admet-337	302	11	bi836845 asp8273	PERSON
admet-337	303	1	103	CARDINAL
admet-337	303	2	50%	PERCENT
admet-337	303	3	80%	PERCENT
admet-337	303	4	1	CARDINAL
admet-337	303	5	nct02588261) asp8273	MONEY
admet-337	303	6	104	CARDINAL
admet-337	303	7	i/ii	EVENT
admet-337	303	8	55%	PERCENT
admet-337	303	9	86%	PERCENT
admet-337	303	10	i/ii	EVENT
admet-337	303	11	106	CARDINAL
admet-337	304	1	1	CARDINAL
admet-337	304	2	1	CARDINAL
admet-337	305	1	105	CARDINAL
admet-337	305	2	71%	PERCENT
admet-337	305	3	100%	PERCENT
admet-337	306	1	107	CARDINAL
admet-337	306	2	4(3	CARDINAL
admet-337	306	3	2016	CARDINAL
admet-337	306	4	186	CARDINAL
admet-337	306	5	10.5599	CARDINAL
admet-337	306	6	197	CARDINAL
admet-337	306	7	third	ORDINAL
admet-337	306	8	asp8273	ORG
admet-337	306	9	l858r	PERSON
admet-337	306	10	19	CARDINAL
admet-337	307	1	35.5 to 44 %	PERCENT
admet-337	307	2	dcrs	ORG
admet-337	307	3	65 to 91 %	PERCENT
admet-337	307	4	6.7 months to 9.2 months	DATE
admet-337	307	5	103,104	CARDINAL
admet-337	308	1	epitinib	PERSON
admet-337	309	1	3	CARDINAL
admet-337	309	2	2 to 5 %	PERCENT
admet-337	310	1	12	CARDINAL
admet-337	310	2	october 2015	DATE
admet-337	311	1	5	CARDINAL
admet-337	312	1	5	CARDINAL
admet-337	313	1	105	CARDINAL
admet-337	314	1	bbb	ORG
admet-337	315	1	nct02228369	ORG
admet-337	315	2	2	CARDINAL
admet-337	315	3	1	CARDINAL
admet-337	316	1	7.7	CARDINAL
admet-337	316	2	ic50	CARDINAL
admet-337	316	3	106	CARDINAL
admet-337	318	1	egfr tki	ORG
admet-337	318	2	th-4000	CARDINAL
admet-337	319	1	first	ORDINAL
admet-337	320	1	107	CARDINAL
admet-337	321	1	2007	DATE
admet-337	322	1	2p	CARDINAL
admet-337	322	2	6,108	CARDINAL
admet-337	323	1	at least 8	CARDINAL
admet-337	324	1	19	CARDINAL
admet-337	324	2	eml4	DATE
admet-337	324	3	109,110	CARDINAL
admet-337	326	1	eml4	ORDINAL
admet-337	326	2	pi3k/akt	ORG
admet-337	326	3	jak	GPE
admet-337	327	1	6,111	CARDINAL
admet-337	328	1	approximately 3 to 7 %	DATE
admet-337	328	2	112	CARDINAL
admet-337	329	1	three	CARDINAL
admet-337	329	2	3	CARDINAL
admet-337	330	1	alk tkis crizotinib	PERSON
admet-337	330	2	first	ORDINAL
admet-337	330	3	fda	ORG
admet-337	330	4	august 2011	DATE
admet-337	330	5	two	CARDINAL
admet-337	330	6	50 to 60 %	PERCENT
admet-337	330	7	9 months	DATE
admet-337	331	1	113,114	CARDINAL
admet-337	332	1	fda	ORG
admet-337	332	2	november 2013	DATE
admet-337	332	3	1007	DATE
admet-337	333	1	347	CARDINAL
admet-337	333	2	al. admet	ORG
admet-337	333	3	4(3	CARDINAL
admet-337	333	4	2016	CARDINAL
admet-337	333	5	186	CARDINAL
admet-337	333	6	20 %	PERCENT
admet-337	334	1	crizotinib	PERSON
admet-337	334	2	7.7 months	DATE
admet-337	334	3	3.0 months	DATE
admet-337	334	4	0.49	CARDINAL
admet-337	334	5	95 %	PERCENT
admet-337	334	6	0.37-0.64	CARDINAL
admet-337	335	1	115	CARDINAL
admet-337	336	1	first	ORDINAL
admet-337	336	2	1014	CARDINAL
admet-337	336	3	74 %	PERCENT
admet-337	336	4	45 %	PERCENT
admet-337	336	5	10.9	CARDINAL
admet-337	336	6	7 months	DATE
admet-337	336	7	0.45;95 %	PERCENT
admet-337	336	8	0.35-0.60	CARDINAL
admet-337	337	1	116	CARDINAL
admet-337	338	1	3	CARDINAL
admet-337	338	2	alk tki	ORG
admet-337	338	3	alk tki	ORG
admet-337	338	4	crizotinib ceritinib alectinib	PERSON
admet-337	338	5	alk	PERSON
admet-337	338	6	ret	ORG
admet-337	338	7	atp-competitive	PERSON
admet-337	338	8	atp-competitive	ORG
admet-337	338	9	atp-competitive clinical approval	ORG
admet-337	338	10	first	ORDINAL
admet-337	338	11	second	ORDINAL
admet-337	338	12	second	ORDINAL
admet-337	338	13	alk ic50	ORG
admet-337	338	14	3.6	CARDINAL
admet-337	338	15	0.15	CARDINAL
admet-337	338	16	1.9	CARDINAL
admet-337	343	1	63%	PERCENT
admet-337	343	2	53%	PERCENT
admet-337	343	3	22%	PERCENT
admet-337	343	4	2%	PERCENT
admet-337	343	5	92%	PERCENT
admet-337	343	6	68%	PERCENT
admet-337	343	7	1%	PERCENT
admet-337	343	8	98%	PERCENT
admet-337	343	9	84%	PERCENT
admet-337	343	10	1%	PERCENT
admet-337	343	11	0.06-0.26%	PERCENT
admet-337	343	12	80%	PERCENT
admet-337	344	1	csf	PERSON
admet-337	345	1	86%	PERCENT
admet-337	345	2	4	CARDINAL
admet-337	345	3	up to 70 %	PERCENT
admet-337	347	1	1005	CARDINAL
admet-337	348	1	113,116,117	CARDINAL
admet-337	349	1	approximately 50 to	CARDINAL
admet-337	349	2	3	CARDINAL
admet-337	349	3	4	CARDINAL
admet-337	349	4	less than 5 %	PERCENT
admet-337	350	1	3	CARDINAL
admet-337	350	2	4	CARDINAL
admet-337	350	3	up to 15 %	PERCENT
admet-337	351	1	113,116	CARDINAL
admet-337	353	1	one	CARDINAL
admet-337	353	2	84 %	PERCENT
admet-337	353	3	118	CARDINAL
admet-337	354	1	4(3	CARDINAL
admet-337	354	2	2016	CARDINAL
admet-337	354	3	186	CARDINAL
admet-337	354	4	10.5599	CARDINAL
admet-337	354	5	199	CARDINAL
admet-337	355	1	119	CARDINAL
admet-337	356	1	about 5 %	PERCENT
admet-337	356	2	120	CARDINAL
admet-337	357	1	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1	QUANTITY
admet-337	358	1	pf-2341066	NORP
admet-337	358	2	xalkori	GPE
admet-337	358	3	atp	ORG
admet-337	359	1	111	CARDINAL
admet-337	360	1	alk	ORG
admet-337	360	2	npm-alk	ORG
admet-337	360	3	ic50	ORG
admet-337	360	4	between 25 to 50	CARDINAL
admet-337	360	5	ic50	ORG
admet-337	360	6	5 to 20	CARDINAL
admet-337	361	1	121	CARDINAL
admet-337	362	1	ic50	ORG
admet-337	362	2	between 250 to 340	CARDINAL
admet-337	363	1	124,125	CARDINAL
admet-337	364	1	250 mg	QUANTITY
admet-337	366	1	43 %	PERCENT
admet-337	366	2	4 hours	TIME
admet-337	367	1	91 %	PERCENT
admet-337	367	2	1772l	DATE
admet-337	367	3	42 hours	TIME
admet-337	367	4	126	CARDINAL
admet-337	368	1	cyp3a4	NORP
admet-337	368	2	126,127	CARDINAL
admet-337	369	1	15 days	DATE
admet-337	370	1	100	CARDINAL
admet-337	370	2	64.5 l	QUANTITY
admet-337	370	3	60.1 l	QUANTITY
admet-337	370	4	15 and 28 days	DATE
admet-337	371	1	cyp3a4	NORP
admet-337	372	1	128	CARDINAL
admet-337	373	1	63 %	PERCENT
admet-337	373	2	53 %	PERCENT
admet-337	373	3	22 %	PERCENT
admet-337	373	4	2.3 %	PERCENT
admet-337	374	1	126	CARDINAL
admet-337	378	1	29-year-old	DATE
admet-337	378	2	7.5 months	DATE
admet-337	378	3	crizotinib	PERSON
admet-337	379	1	237 ng/ml	QUANTITY
admet-337	379	2	only 0.616 ng/ml	QUANTITY
admet-337	379	3	0.0026	CARDINAL
admet-337	379	4	125	CARDINAL
admet-337	381	1	58-year-old	DATE
admet-337	381	2	crizotinib	PERSON
admet-337	381	3	0.0006	CARDINAL
admet-337	382	1	129	CARDINAL
admet-337	383	1	1005	DATE
admet-337	383	2	1007	DATE
admet-337	383	3	275 (	PERCENT
admet-337	383	4	31 %	PERCENT
admet-337	383	5	888	CARDINAL
admet-337	384	1	56 %	PERCENT
admet-337	384	2	12 weeks	DATE
admet-337	385	1	7 months	DATE
admet-337	386	1	62 %	PERCENT
admet-337	386	2	13.2 months	DATE
admet-337	387	1	20 %	PERCENT
admet-337	387	2	130	CARDINAL
admet-337	388	1	second	ORDINAL
admet-337	389	1	crizotinib grace	PERSON
admet-337	390	1	al. admet	ORG
admet-337	390	2	4(3	CARDINAL
admet-337	390	3	2016	CARDINAL
admet-337	390	4	186	CARDINAL
admet-337	390	5	211 200	CARDINAL
admet-337	391	1	alk	ORG
admet-337	392	1	131,132	CARDINAL
admet-337	393	1	alk	ORG
admet-337	393	2	s1206y	NORP
admet-337	394	1	131,133	CARDINAL
admet-337	395	1	second	ORDINAL
admet-337	395	2	alk tkis	ORG
admet-337	396	1	137	CARDINAL
admet-337	397	1	132	CARDINAL
admet-337	398	1	132	CARDINAL
admet-337	399	1	90	CARDINAL
admet-337	400	1	her2	PERSON
admet-337	400	2	138	CARDINAL
admet-337	401	1	1	CARDINAL
admet-337	401	2	second	ORDINAL
admet-337	402	1	139	CARDINAL
admet-337	403	1	first	ORDINAL
admet-337	403	2	second	ORDINAL
admet-337	403	3	alk tki	ORG
admet-337	403	4	us	GPE
admet-337	404	1	s1206y	NORP
admet-337	405	1	136	CARDINAL
admet-337	406	1	april 2014	DATE
admet-337	406	2	fda	ORG
admet-337	407	1	130	CARDINAL
admet-337	408	1	at least 400	CARDINAL
admet-337	408	2	58 %	PERCENT
admet-337	408	3	56 %	PERCENT
admet-337	409	1	7.0 months	DATE
admet-337	409	2	95 %	PERCENT
admet-337	409	3	5.6 to	CARDINAL
admet-337	409	4	9.5	CARDINAL
admet-337	410	1	14	CARDINAL
admet-337	412	1	14	CARDINAL
admet-337	413	1	246	CARDINAL
admet-337	413	2	58.5 %	PERCENT
admet-337	413	3	9.7 months	DATE
admet-337	413	4	first	ORDINAL
admet-337	413	5	6.1 weeks	DATE
admet-337	413	6	8.2 months	DATE
admet-337	413	7	140	CARDINAL
admet-337	414	1	ascend-2	PERSON
admet-337	414	2	140	CARDINAL
admet-337	415	1	38.6 %	PERCENT
admet-337	415	2	5.7 months	DATE
admet-337	416	1	71.4 %	PERCENT
admet-337	416	2	28 %	PERCENT
admet-337	417	1	5.4 months	DATE
admet-337	417	2	11.3 months	DATE
admet-337	417	3	141	CARDINAL
admet-337	418	1	alk tki-naïve	PERSON
admet-337	419	1	124	CARDINAL
admet-337	420	1	63.7 %	PERCENT
admet-337	420	2	89.5 %	PERCENT
admet-337	420	3	11.1 months	DATE
admet-337	421	1	142	CARDINAL
admet-337	422	1	4(3	CARDINAL
admet-337	422	2	2016	CARDINAL
admet-337	422	3	186	CARDINAL
admet-337	422	4	10.5599	CARDINAL
admet-337	422	5	201	CARDINAL
admet-337	423	1	60 to 80 %	PERCENT
admet-337	423	2	only 5	CARDINAL
admet-337	423	3	3	CARDINAL
admet-337	423	4	4	CARDINAL
admet-337	424	1	approximately 58 %	PERCENT
admet-337	424	2	750	CARDINAL
admet-337	424	3	daily	DATE
admet-337	424	4	at least one	CARDINAL
admet-337	424	5	143	CARDINAL
admet-337	425	1	ceritinib	NORP
admet-337	425	2	only 7 to	DATE
admet-337	425	3	14,140	CARDINAL
admet-337	426	1	less than 5 %	PERCENT
admet-337	427	1	3	CARDINAL
admet-337	427	2	4	CARDINAL
admet-337	427	3	approximately 21 %	PERCENT
admet-337	429	1	ceritinib	NORP
admet-337	429	2	1	CARDINAL
admet-337	429	3	3	CARDINAL
admet-337	429	4	4	CARDINAL
admet-337	429	5	up to 13 %	PERCENT
admet-337	431	1	14,140	CARDINAL
admet-337	432	1	5	CARDINAL
admet-337	432	2	second	ORDINAL
admet-337	434	1	crizotinib	PERSON
admet-337	434	2	136,143	CARDINAL
admet-337	435	1	ic50	ORG
admet-337	435	2	0.15	CARDINAL
admet-337	435	3	ic50 3.6	PRODUCT
admet-337	436	1	ic50	ORG
admet-337	436	2	25	CARDINAL
admet-337	436	3	136,144	CARDINAL
admet-337	437	1	750 mg	QUANTITY
admet-337	437	2	daily	DATE
admet-337	438	1	41 to 43 %	PERCENT
admet-337	440	1	4 to 6 hours	TIME
admet-337	441	1	ceritinib	PERSON
admet-337	441	2	97 %	PERCENT
admet-337	441	3	4230l	DATE
admet-337	441	4	15 days	DATE
admet-337	444	1	ceritinib	PERSON
admet-337	444	2	half	CARDINAL
admet-337	444	3	41 hours	TIME
admet-337	444	4	88.5	CARDINAL
admet-337	444	5	one	CARDINAL
admet-337	444	6	33.2l	CARDINAL
admet-337	445	1	92.3 %	PERCENT
admet-337	445	2	68 %	PERCENT
admet-337	446	1	143,144	CARDINAL
admet-337	449	1	80 %	PERCENT
admet-337	450	1	5	CARDINAL
admet-337	450	2	6	CARDINAL
admet-337	450	3	2	CARDINAL
admet-337	450	4	3	CARDINAL
admet-337	450	5	141	CARDINAL
admet-337	451	1	80 %	PERCENT
admet-337	451	2	2	CARDINAL
admet-337	451	3	ceritinib	NORP
admet-337	452	1	142	CARDINAL
admet-337	453	1	csf	PERSON
admet-337	454	1	10	CARDINAL
admet-337	454	2	7.5 months	DATE
admet-337	455	1	11	CARDINAL
admet-337	455	2	10	CARDINAL
admet-337	455	3	5	CARDINAL
admet-337	455	4	11	CARDINAL
admet-337	456	1	3	CARDINAL
admet-337	456	2	1	CARDINAL
admet-337	456	3	1	CARDINAL
admet-337	456	4	al. admet	ORG
admet-337	456	5	4(3	CARDINAL
admet-337	456	6	2016	CARDINAL
admet-337	456	7	186	CARDINAL
admet-337	457	1	f1174v	ORG
admet-337	458	1	two	CARDINAL
admet-337	458	2	s1206y	NORP
admet-337	460	1	145	CARDINAL
admet-337	461	1	second	ORDINAL
admet-337	461	2	alk tki	ORG
admet-337	462	1	146,147	CARDINAL
admet-337	463	1	japanese	NORP
admet-337	463	2	alk tki	ORG
admet-337	463	3	300 mg	QUANTITY
admet-337	463	4	93.5 %	PERCENT
admet-337	464	1	148	CARDINAL
admet-337	465	1	600	CARDINAL
admet-337	465	2	daily	DATE
admet-337	465	3	55 %	PERCENT
admet-337	465	4	149	CARDINAL
admet-337	466	1	december 2015	DATE
admet-337	466	2	fda	ORG
admet-337	467	1	87	CARDINAL
admet-337	467	2	48	CARDINAL
admet-337	468	1	150	CARDINAL
admet-337	469	1	j-alex	ORG
admet-337	469	2	american	NORP
admet-337	469	3	annual	DATE
admet-337	470	1	207	CARDINAL
admet-337	470	2	japanese	NORP
admet-337	470	3	alk tki naïve	PERSON
admet-337	470	4	300 mg	QUANTITY
admet-337	470	5	daily	DATE
admet-337	470	6	crizotinib 250 mg	PRODUCT
admet-337	470	7	daily	DATE
admet-337	471	1	0.34	CARDINAL
admet-337	471	2	99.6826 %	PERCENT
admet-337	471	3	0.17-0.70	CARDINAL
admet-337	472	1	95 %	PERCENT
admet-337	472	2	20.3	CARDINAL
admet-337	472	3	10.2 months	DATE
admet-337	472	4	95 %	PERCENT
admet-337	472	5	8.2-12	CARDINAL
admet-337	473	1	151	CARDINAL
admet-337	476	1	approximately 30 %	PERCENT
admet-337	476	2	1-2	CARDINAL
admet-337	477	1	1-2	QUANTITY
admet-337	477	2	13-36 %	PERCENT
admet-337	478	1	3	CARDINAL
admet-337	478	2	4	CARDINAL
admet-337	478	3	less than 5 %	PERCENT
admet-337	478	4	5 to 6 %	PERCENT
admet-337	479	1	one	CARDINAL
admet-337	480	1	36 %	PERCENT
admet-337	480	2	16 %	PERCENT
admet-337	481	1	2 to 9 %	PERCENT
admet-337	481	2	148-150	CARDINAL
admet-337	482	1	9-ethyl-6,6-dimethyl-8-(4	QUANTITY
admet-337	483	1	alecensa	PERSON
admet-337	483	2	roche	ORG
admet-337	484	1	ic50	ORG
admet-337	484	2	1.9	CARDINAL
admet-337	484	3	ic50	ORG
admet-337	484	4	3.0	CARDINAL
admet-337	485	1	20	CARDINAL
admet-337	485	2	152	CARDINAL
admet-337	486	1	ret	ORG
admet-337	486	2	ic50	ORG
admet-337	486	3	4.8	CARDINAL
admet-337	486	4	ret	ORG
admet-337	486	5	153	CARDINAL
admet-337	487	1	600 mg	QUANTITY
admet-337	487	2	daily	DATE
admet-337	488	1	154	CARDINAL
admet-337	490	1	44 %	PERCENT
admet-337	491	1	m4	ORG
admet-337	491	2	246 ng	QUANTITY
admet-337	491	3	45 %	PERCENT
admet-337	491	4	7 days	DATE
admet-337	492	1	fed	ORG
admet-337	492	2	37 %	PERCENT
admet-337	492	3	4(3	CARDINAL
admet-337	492	4	2016	CARDINAL
admet-337	492	5	186	CARDINAL
admet-337	492	6	10.5599	CARDINAL
admet-337	492	7	203	CARDINAL
admet-337	492	8	3-fold	CARDINAL
admet-337	492	9	154	CARDINAL
admet-337	493	1	4,016	CARDINAL
admet-337	493	2	m4	PRODUCT
admet-337	494	1	alectinib	PERSON
admet-337	494	2	81.9l	CARDINAL
admet-337	494	3	217	CARDINAL
admet-337	494	4	m4.	GPE
admet-337	495	1	84 %	PERCENT
admet-337	495	2	6 %	PERCENT
admet-337	495	3	m4	ORG
admet-337	495	4	148,149,154	CARDINAL
admet-337	498	1	154	CARDINAL
admet-337	500	1	one	CARDINAL
admet-337	500	2	21	CARDINAL
admet-337	501	1	12 (57 %	PERCENT
admet-337	502	1	21	CARDINAL
admet-337	502	2	52 %	PERCENT
admet-337	502	3	six (29 %	PERCENT
admet-337	502	4	five (24 %	PERCENT
admet-337	503	1	90 %	PERCENT
admet-337	504	1	four	CARDINAL
admet-337	504	2	two	CARDINAL
admet-337	505	1	600 mg	QUANTITY
admet-337	505	2	daily	DATE
admet-337	505	3	2.69	CARDINAL
admet-337	505	4	3.12	CARDINAL
admet-337	505	5	ic50	PRODUCT
admet-337	505	6	1.9	CARDINAL
admet-337	506	1	149	CARDINAL
admet-337	507	1	japanese	NORP
admet-337	507	2	15	CARDINAL
admet-337	507	3	12	CARDINAL
admet-337	509	1	3	CARDINAL
admet-337	509	2	2	CARDINAL
admet-337	509	3	more than 300 days	DATE
admet-337	509	4	148	CARDINAL
admet-337	510	1	16	CARDINAL
admet-337	511	1	100 %	PERCENT
admet-337	511	2	75 %	PERCENT
admet-337	512	1	four (25 %	PERCENT
admet-337	512	2	eight (50 %	PERCENT
admet-337	513	1	11.1 months	DATE
admet-337	514	1	150	CARDINAL
admet-337	516	1	4	CARDINAL
admet-337	520	1	155	CARDINAL
admet-337	522	1	136	CARDINAL
admet-337	523	1	137	CARDINAL
admet-337	525	1	5 month	DATE
admet-337	525	2	156	CARDINAL
admet-337	526	1	second	ORDINAL
admet-337	526	2	alk tkis	ORG
admet-337	527	1	al. admet	ORG
admet-337	527	2	4(3	CARDINAL
admet-337	527	3	2016	CARDINAL
admet-337	527	4	186	CARDINAL
admet-337	527	5	211 204	CARDINAL
admet-337	527	6	4	CARDINAL
admet-337	528	1	157	CARDINAL
admet-337	528	2	ceritinib	NORP
admet-337	528	3	lorlatinib	PERSON
admet-337	528	4	jh-viii-157-02	PERSON
admet-337	528	5	ceritinib	NORP
admet-337	528	6	lorlatinib	PERSON
admet-337	528	7	jh-viii-157-02	PERSON
admet-337	528	8	lorlatinib i1171t/n	PERSON
admet-337	528	9	s1206y	NORP
admet-337	528	10	ceritinib	NORP
admet-337	528	11	lorlatinib	PERSON
admet-337	528	12	jh-viii-157-02	PERSON
admet-337	528	13	c1156y alectinib	PERSON
admet-337	528	14	ceritinib	NORP
admet-337	528	15	jh-viii-157-02	PERSON
admet-337	529	1	lorlatinib	PERSON
admet-337	529	2	jh-viii-157-02	PERSON
admet-337	529	3	g1202r brigatinib	PERSON
admet-337	529	4	lorlatinib	PERSON
admet-337	529	5	jh-viii-157-02	PERSON
admet-337	529	6	5	CARDINAL
admet-337	529	7	second	ORDINAL
admet-337	530	1	ic50	ORG
admet-337	530	2	1.9	CARDINAL
admet-337	530	3	161	CARDINAL
admet-337	531	1	163	CARDINAL
admet-337	532	1	74 %	PERCENT
admet-337	532	2	13.4 months	DATE
admet-337	532	3	163	CARDINAL
admet-337	534	1	december 2015	DATE
admet-337	534	2	222	CARDINAL
admet-337	534	3	90 mg	QUANTITY
admet-337	534	4	180 mg/day	QUANTITY
admet-337	535	1	46 %	PERCENT
admet-337	535	2	8.8 months	DATE
admet-337	535	3	90 mg/day	QUANTITY
admet-337	535	4	54 %	PERCENT
admet-337	535	5	11.1 months	DATE
admet-337	535	6	180 mg	QUANTITY
admet-337	536	1	3	CARDINAL
admet-337	536	2	cpk	GPE
admet-337	536	3	8 %	PERCENT
admet-337	536	4	3 %	PERCENT
admet-337	537	1	7 days	DATE
admet-337	539	1	162	CARDINAL
admet-337	540	1	lorlatinib	PERSON
admet-337	540	2	third	ORDINAL
admet-337	541	1	54	CARDINAL
admet-337	541	2	50 %	PERCENT
admet-337	541	3	44 %	PERCENT
admet-337	541	4	22 %	PERCENT
admet-337	542	1	164	CARDINAL
admet-337	543	1	3	CARDINAL
admet-337	543	2	4	CARDINAL
admet-337	543	3	9 %	PERCENT
admet-337	546	1	alk	ORG
admet-337	546	2	160	CARDINAL
admet-337	547	1	alk	ORG
admet-337	548	1	i/ii	PRODUCT
admet-337	548	2	6	CARDINAL
admet-337	548	3	at least 200	CARDINAL
admet-337	548	4	x-396	DATE
admet-337	548	5	83 %	PERCENT
admet-337	549	1	4(3	CARDINAL
admet-337	549	2	2016	CARDINAL
admet-337	549	3	186	CARDINAL
admet-337	549	4	10.5599	CARDINAL
admet-337	549	5	205	CARDINAL
admet-337	550	1	165	CARDINAL
admet-337	550	2	44 %	PERCENT
admet-337	550	3	15	CARDINAL
admet-337	551	1	166	CARDINAL
admet-337	551	2	5	CARDINAL
admet-337	552	1	alk tkis	PERSON
admet-337	553	1	162,163	CARDINAL
admet-337	553	2	alk egfr alk l1196m	PERSON
admet-337	553	3	74%	PERCENT
admet-337	553	4	13.4	CARDINAL
admet-337	553	5	orr 46-54%	PERSON
admet-337	554	1	164	CARDINAL
admet-337	554	2	orr	PERSON
admet-337	554	3	50%	PERCENT
admet-337	554	4	44%	PERCENT
admet-337	554	5	x-396	DATE
admet-337	555	1	165	CARDINAL
admet-337	555	2	alk crizotinib-resistance	PERSON
admet-337	555	3	i/ii	EVENT
admet-337	555	4	n=6	PERSON
admet-337	555	5	83%	PERCENT
admet-337	556	1	166	CARDINAL
admet-337	556	2	44%	PERCENT
admet-337	557	1	169	CARDINAL
admet-337	557	2	trkc	ORG
admet-337	557	3	1	CARDINAL
admet-337	558	1	168	CARDINAL
admet-337	558	2	trkc	ORG
admet-337	558	3	120 mg	QUANTITY
admet-337	558	4	orr 3	PERSON
admet-337	558	5	120 mg	QUANTITY
admet-337	558	6	orr 5	PERSON
admet-337	558	7	9	CARDINAL
admet-337	558	8	i/ii	EVENT
admet-337	558	9	trkc	GPE
admet-337	559	1	mprip	PERSON
admet-337	559	2	cd74	PRODUCT
admet-337	559	3	up to 3 %	PERCENT
admet-337	560	1	167	CARDINAL
admet-337	561	1	3	CARDINAL
admet-337	561	2	the 120mg	PRODUCT
admet-337	561	3	daily	DATE
admet-337	561	4	5	CARDINAL
admet-337	561	5	9	CARDINAL
admet-337	561	6	168	CARDINAL
admet-337	563	1	169	CARDINAL
admet-337	564	1	ntrk1, ntrk2, ntrk3	ORG
admet-337	564	2	alk	PERSON
admet-337	565	1	alk tkis	PERSON
admet-337	565	2	pembrolizumab	PERSON
admet-337	566	1	second	ORDINAL
admet-337	566	2	second	ORDINAL
admet-337	567	1	171-173	CARDINAL
admet-337	568	1	nivolumab	PERSON
admet-337	568	2	first	ORDINAL
admet-337	568	3	174,175	CARDINAL
admet-337	570	1	alk tkis	PERSON
admet-337	572	1	al. admet	ORG
admet-337	572	2	4(3	CARDINAL
admet-337	572	3	2016	CARDINAL
admet-337	572	4	186	CARDINAL
admet-337	572	5	211 206	CARDINAL
admet-337	572	6	057	CARDINAL
admet-337	572	7	keynote-010	PERSON
admet-337	572	8	pembrolizumab	PERSON
admet-337	573	1	171,173	CARDINAL
admet-337	574	1	176,177	CARDINAL
admet-337	575	1	alk-mutated nsclcs	ORG
admet-337	576	1	178	CARDINAL
admet-337	577	1	egfr tki	PRODUCT
admet-337	578	1	tatton	PERSON
admet-337	578	2	34	CARDINAL
admet-337	579	1	2016	CARDINAL
admet-337	579	2	european	NORP
admet-337	579	3	31	CARDINAL
admet-337	580	1	64.5 %	PERCENT
admet-337	580	2	3/4	CARDINAL
admet-337	580	3	14.7 %	PERCENT
admet-337	580	4	182	CARDINAL
admet-337	585	1	egfr tkis	PERSON
admet-337	587	1	alk tkis	PERSON
admet-337	590	1	1	CARDINAL
admet-337	590	2	s. mcguire	PERSON
admet-337	590	3	2014	DATE
admet-337	591	1	geneva	GPE
admet-337	591	2	switzerland	GPE
admet-337	591	3	2015	DATE
admet-337	592	1	adv.	ORG
admet-337	593	1	nutr	GPE
admet-337	593	2	7 (	PERCENT
admet-337	593	3	2016	CARDINAL
admet-337	593	4	418	CARDINAL
admet-337	594	1	2	CARDINAL
admet-337	594	2	k.d. miller	PERSON
admet-337	594	3	a. jemal	PERSON
admet-337	595	1	j. clin	PERSON
admet-337	596	1	66	CARDINAL
admet-337	596	2	2016	CARDINAL
admet-337	596	3	7-30	DATE
admet-337	597	1	3	CARDINAL
admet-337	597	2	k. chansky	PERSON
admet-337	597	3	j.p.	PERSON
admet-337	597	4	j.j. crowley	PERSON
admet-337	598	1	j. thorac	PERSON
admet-337	600	1	4 (	PERCENT
admet-337	600	2	2009	DATE
admet-337	600	3	792	CARDINAL
admet-337	601	1	4	CARDINAL
admet-337	601	2	p.a. janne	PERSON
admet-337	601	3	j.c. lee	PERSON
admet-337	601	4	1497-1500	CARDINAL
admet-337	602	1	5	CARDINAL
admet-337	602	2	j.y.	ORG
admet-337	602	3	douillard	PERSON
admet-337	602	4	m. cobo	PERSON
admet-337	604	1	j. cancer	PERSON
admet-337	605	1	110	CARDINAL
admet-337	605	2	2014	DATE
admet-337	605	3	55	CARDINAL
admet-337	606	1	6	CARDINAL
admet-337	606	2	y.l. choi	GPE
admet-337	606	3	m. enomoto	PERSON
admet-337	606	4	448	CARDINAL
admet-337	606	5	2007	DATE
admet-337	606	6	561	CARDINAL
admet-337	607	1	7	CARDINAL
admet-337	607	2	k. cetin	PERSON
admet-337	607	3	d.s. ettinger	PERSON
admet-337	607	4	hei	ORG
admet-337	607	5	c.d. o'malley	PERSON
admet-337	607	6	clin	PERSON
admet-337	609	1	3 (2011	DATE
admet-337	609	2	139	CARDINAL
admet-337	610	1	8	CARDINAL
admet-337	610	2	scagliotti	NORP
admet-337	610	3	p. parikh	PERSON
admet-337	610	4	j. von pawel	PERSON
admet-337	611	1	j. clin	PERSON
admet-337	612	1	oncol.	DATE
admet-337	613	1	26	CARDINAL
admet-337	613	2	3543-3551	DATE
admet-337	614	1	9	CARDINAL
admet-337	614	2	patel	PERSON
admet-337	614	3	m.a.	GPE
admet-337	614	4	socinski	PERSON
admet-337	614	5	e.b. garon	PERSON
admet-337	615	1	j. clin	PERSON
admet-337	616	1	oncol.	DATE
admet-337	617	1	2013) 4349-4357	DATE
admet-337	618	1	10	CARDINAL
admet-337	618	2	n. thatcher	PERSON
admet-337	618	3	hirsch	PERSON
admet-337	620	1	16	CARDINAL
admet-337	620	2	763	CARDINAL
admet-337	621	1	11	CARDINAL
admet-337	621	2	wu	PERSON
admet-337	621	3	c. zhou	PERSON
admet-337	621	4	c.k. liam	PERSON
admet-337	621	5	ann	PERSON
admet-337	622	1	oncol.	DATE
admet-337	623	1	26	CARDINAL
admet-337	623	2	1883-1889	DATE
admet-337	624	1	12	CARDINAL
admet-337	624	2	p.a. janne	PERSON
admet-337	624	3	j.c. yang	PERSON
admet-337	624	4	d.w.	PERSON
admet-337	625	1	kim	PERSON
admet-337	626	1	j. med	PERSON
admet-337	627	1	372	CARDINAL
admet-337	627	2	2015	CARDINAL
admet-337	627	3	1689	CARDINAL
admet-337	627	4	1699	CARDINAL
admet-337	628	1	4(3	CARDINAL
admet-337	628	2	2016	CARDINAL
admet-337	628	3	186	CARDINAL
admet-337	628	4	10.5599	CARDINAL
admet-337	628	5	207	CARDINAL
admet-337	628	6	13	CARDINAL
admet-337	628	7	l.v. sequist	ORG
admet-337	628	8	j.c. soria	PERSON
admet-337	628	9	j.w.	GPE
admet-337	628	10	goldman	ORG
admet-337	629	1	j. med	PERSON
admet-337	630	1	2015;372:1700	CARDINAL
admet-337	631	1	14	CARDINAL
admet-337	631	2	shaw	ORG
admet-337	631	3	d.w.	PERSON
admet-337	632	1	kim	PERSON
admet-337	632	2	r. mehra	PERSON
admet-337	633	1	j. med.	PERSON
admet-337	634	1	370	CARDINAL
admet-337	634	2	2014	DATE
admet-337	634	3	1189-1197	CARDINAL
admet-337	635	1	15	CARDINAL
admet-337	635	2	d.s. tan	PERSON
admet-337	635	3	clin	PERSON
admet-337	637	1	21	CARDINAL
admet-337	637	2	2745-2752	CARDINAL
admet-337	638	1	16	CARDINAL
admet-337	638	2	s. cohen	PERSON
admet-337	638	3	dev. biol	PERSON
admet-337	639	1	12	CARDINAL
admet-337	639	2	1965	DATE
admet-337	639	3	394	CARDINAL
admet-337	640	1	17	CARDINAL
admet-337	640	2	j. mendelsohn	PERSON
admet-337	640	3	j. baselga	PERSON
admet-337	640	4	19 (2000	CARDINAL
admet-337	640	5	6550-6565	DATE
admet-337	641	1	18	CARDINAL
admet-337	641	2	parker	GPE
admet-337	641	3	m.d. waterfield	PERSON
admet-337	641	4	311	CARDINAL
admet-337	641	5	1984	DATE
admet-337	641	6	483	CARDINAL
admet-337	642	1	19	CARDINAL
admet-337	642	2	m. scaltriti	PERSON
admet-337	642	3	j. baselga	PERSON
admet-337	642	4	clin	PERSON
admet-337	644	1	12 (2006	DATE
admet-337	644	2	5268-5272	DATE
admet-337	645	1	20	CARDINAL
admet-337	645	2	lynch	GPE
admet-337	645	3	d.w. bell	ORG
admet-337	645	4	r. sordella	PERSON
admet-337	646	1	j. med.	PERSON
admet-337	647	1	350	CARDINAL
admet-337	647	2	2004	DATE
admet-337	648	1	21	CARDINAL
admet-337	648	2	w. pao	PERSON
admet-337	648	3	miller	ORG
admet-337	648	4	m. zakowski	PERSON
admet-337	650	1	acad	ORG
admet-337	651	1	sci. u.s.a.	ORG
admet-337	652	1	101	CARDINAL
admet-337	652	2	2004	DATE
admet-337	652	3	13306-13311	DATE
admet-337	653	1	22	CARDINAL
admet-337	653	2	sharma	ORG
admet-337	653	3	d.w. bell	PERSON
admet-337	653	4	j. settleman	PERSON
admet-337	653	5	d.a. haber	PERSON
admet-337	653	6	nat	DATE
admet-337	654	1	7 (2007	DATE
admet-337	654	2	169	CARDINAL
admet-337	655	1	23	CARDINAL
admet-337	655	2	h. yasuda	PERSON
admet-337	655	3	t. tani	GPE
admet-337	656	1	6 (	PERCENT
admet-337	656	2	38789-38803	DATE
admet-337	657	1	24	CARDINAL
admet-337	657	2	costa	GPE
admet-337	657	3	s.t. schumer	PERSON
admet-337	657	4	d.g.	PERSON
admet-337	657	5	s. kobayashi	PERSON
admet-337	657	6	j. clin	PERSON
admet-337	658	1	oncol.	DATE
admet-337	659	1	26	CARDINAL
admet-337	660	1	1184-6	CARDINAL
admet-337	661	1	25	CARDINAL
admet-337	661	2	j. rodrigues pereira	PERSON
admet-337	662	1	j. med	PERSON
admet-337	663	1	353	CARDINAL
admet-337	663	2	2005	DATE
admet-337	663	3	123	CARDINAL
admet-337	664	1	26	CARDINAL
admet-337	664	2	f. cappuzzo	PERSON
admet-337	664	3	l. stelmakh	PERSON
admet-337	666	1	11	CARDINAL
admet-337	666	2	2010	DATE
admet-337	666	3	521	CARDINAL
admet-337	667	1	27	CARDINAL
admet-337	667	2	r. rosell	PERSON
admet-337	667	3	e. carcereny	PERSON
admet-337	667	4	r. gervais	PERSON
admet-337	669	1	13	CARDINAL
admet-337	669	2	2012	DATE
admet-337	669	3	239	CARDINAL
admet-337	670	1	28	CARDINAL
admet-337	670	2	c. zhou	PERSON
admet-337	670	3	y.l. wu	PERSON
admet-337	670	4	g. chen	PERSON
admet-337	672	1	12 (2011	DATE
admet-337	672	2	735	CARDINAL
admet-337	673	1	29	CARDINAL
admet-337	673	2	wu	PERSON
admet-337	673	3	c. zhou	PERSON
admet-337	673	4	c.k. liam	PERSON
admet-337	673	5	ann	PERSON
admet-337	674	1	oncol.	DATE
admet-337	675	1	26	CARDINAL
admet-337	675	2	1883-1889	DATE
admet-337	676	1	30	CARDINAL
admet-337	676	2	r. lima	PERSON
admet-337	676	3	a. moreira	PERSON
admet-337	677	1	j. dermatol	PERSON
admet-337	678	1	19	CARDINAL
admet-337	678	2	2009	DATE
admet-337	678	3	248	CARDINAL
admet-337	679	1	31	CARDINAL
admet-337	679	2	carey	PERSON
admet-337	679	3	a.j. garton	PERSON
admet-337	679	4	m.s. romero	PERSON
admet-337	680	1	66	CARDINAL
admet-337	680	2	8163-8171	DATE
admet-337	681	1	32	CARDINAL
admet-337	681	2	n. yamamoto	PERSON
admet-337	681	3	m. honma	PERSON
admet-337	682	1	80	CARDINAL
admet-337	683	1	2011	DATE
admet-337	683	2	466	CARDINAL
admet-337	684	1	33	CARDINAL
admet-337	684	2	johnson	PERSON
admet-337	684	3	m. cohen	PERSON
admet-337	684	4	r. sridhara	PERSON
admet-337	685	1	clin	PERSON
admet-337	687	1	11 (2005	DATE
admet-337	687	2	6414-6421	DATE
admet-337	688	1	34	CARDINAL
admet-337	688	2	m. ranson	PERSON
admet-337	688	3	h. shaw	PERSON
admet-337	688	4	j. wolf	PERSON
admet-337	690	1	66	CARDINAL
admet-337	690	2	2010	DATE
admet-337	690	3	53	CARDINAL
admet-337	691	1	35	CARDINAL
admet-337	691	2	j. ling	PERSON
admet-337	691	3	s. fettner	PERSON
admet-337	691	4	b.l. lum	PERSON
admet-337	691	5	m. riek	PERSON
admet-337	691	6	a. rakhit	PERSON
admet-337	692	1	19 (2008	DATE
admet-337	692	2	209	CARDINAL
admet-337	693	1	36	CARDINAL
admet-337	693	2	van leeuwen	PERSON
admet-337	693	3	r. peric	PERSON
admet-337	693	4	k.g.	GPE
admet-337	694	1	j. clin	PERSON
admet-337	695	1	oncol.	DATE
admet-337	696	1	34	CARDINAL
admet-337	696	2	2016	CARDINAL
admet-337	697	1	37	CARDINAL
admet-337	697	2	s.m. eppler	GPE
admet-337	697	3	j. wolf	PERSON
admet-337	697	4	clin	PERSON
admet-337	700	1	80 (2006	DATE
admet-337	700	2	136	CARDINAL
admet-337	701	1	38	CARDINAL
admet-337	701	2	b. blanchet	PERSON
admet-337	701	3	f. goldwasser	PERSON
admet-337	702	1	j. med.	PERSON
admet-337	703	1	2011	DATE
admet-337	703	2	379	CARDINAL
admet-337	704	1	39	CARDINAL
admet-337	704	2	p. haluska	PERSON
admet-337	704	3	l. rosen	PERSON
admet-337	706	1	69	CARDINAL
admet-337	706	2	2012	DATE
admet-337	706	3	605	CARDINAL
admet-337	707	1	40	CARDINAL
admet-337	707	2	s. marchetti	PERSON
admet-337	707	3	n.a. de vries	ORG
admet-337	710	1	7 (2008	DATE
admet-337	710	2	2280-2287	CARDINAL
admet-337	711	1	41	CARDINAL
admet-337	711	2	a. hamada	PERSON
admet-337	711	3	j. sasaki	PERSON
admet-337	711	4	s. saeki	PERSON
admet-337	711	5	13	DATE
admet-337	711	6	2012	DATE
admet-337	711	7	615-624	CARDINAL
admet-337	712	1	42	CARDINAL
admet-337	713	1	clin	PERSON
admet-337	714	1	pharmacokinet	PERSON
admet-337	715	1	52	CARDINAL
admet-337	715	2	2013	DATE
admet-337	715	3	593	CARDINAL
admet-337	716	1	43	CARDINAL
admet-337	716	2	j. li	PERSON
admet-337	716	3	m. zhao	PERSON
admet-337	716	4	m. hidalgo	PERSON
admet-337	716	5	clin	GPE
admet-337	718	1	13 (2007	DATE
admet-337	718	2	3731-3737	CARDINAL
admet-337	719	1	44	CARDINAL
admet-337	719	2	j. ling	PERSON
admet-337	719	3	k.a. johnson	PERSON
admet-337	719	4	z. miao	PERSON
admet-337	720	1	dispos	PERSON
admet-337	721	1	34 (2006	DATE
admet-337	721	2	420	CARDINAL
admet-337	722	1	45	CARDINAL
admet-337	722	2	k. masago	PERSON
admet-337	722	3	m. fukudo	PERSON
admet-337	723	1	j. thorac	PERSON
admet-337	724	1	oncol.	DATE
admet-337	725	1	5	CARDINAL
admet-337	725	2	2010	DATE
admet-337	725	3	601	CARDINAL
admet-337	726	1	46	CARDINAL
admet-337	726	2	k. masago	PERSON
admet-337	726	3	m. fukudo	PERSON
admet-337	727	1	j. thorac	PERSON
admet-337	728	1	oncol.	DATE
admet-337	729	1	5	CARDINAL
admet-337	729	2	2010	DATE
admet-337	729	3	950	CARDINAL
admet-337	730	1	47	CARDINAL
admet-337	730	2	kim	PERSON
admet-337	730	3	d.h. lee	PERSON
admet-337	731	1	65	CARDINAL
admet-337	731	2	2009	DATE
admet-337	731	3	351	CARDINAL
admet-337	732	1	48	CARDINAL
admet-337	732	2	n. dhruva	PERSON
admet-337	732	3	m.a.	PERSON
admet-337	732	4	socinski	PERSON
admet-337	732	5	j. clin	PERSON
admet-337	733	1	oncol.	DATE
admet-337	734	1	27	CARDINAL
admet-337	734	2	2009	DATE
admet-337	734	3	2	CARDINAL
admet-337	735	1	49	CARDINAL
admet-337	735	2	a. hata	PERSON
admet-337	735	3	r. kaji	PERSON
admet-337	735	4	s. fujita	PERSON
admet-337	735	5	n. katakami	PERSON
admet-337	735	6	j. thorac	PERSON
admet-337	737	1	6 (2011	DATE
admet-337	737	2	653	CARDINAL
admet-337	738	1	50	CARDINAL
admet-337	738	2	g.r. oxnard	PERSON
admet-337	738	3	m.g. kris	GPE
admet-337	739	1	13 (2011	DATE
admet-337	740	1	51	CARDINAL
admet-337	740	2	k.e	DATE
admet-337	740	3	mengwasser, a.v. toms	ORG
admet-337	742	1	acad	ORG
admet-337	743	1	sci. u.s.a.	ORG
admet-337	744	1	105	CARDINAL
admet-337	744	2	2008	DATE
admet-337	744	3	2070-2075	CARDINAL
admet-337	745	1	52	CARDINAL
admet-337	745	2	w. pao	PERSON
admet-337	745	3	v.a. miller	ORG
admet-337	745	4	k.a. politi	PERSON
admet-337	746	1	plos med	PERSON
admet-337	747	1	2005	DATE
admet-337	747	2	2	CARDINAL
admet-337	748	1	53	CARDINAL
admet-337	748	2	j. stamos	PERSON
admet-337	748	3	m.x .sliwkowski	PERSON
admet-337	748	4	c. eigenbrot	PERSON
admet-337	748	5	j. biol	PERSON
admet-337	750	1	277	CARDINAL
admet-337	750	2	2002	DATE
admet-337	750	3	46265-46272	DATE
admet-337	751	1	54	CARDINAL
admet-337	751	2	j. bean	PERSON
admet-337	751	3	c. brennan	PERSON
admet-337	751	4	j.y.	GPE
admet-337	753	1	acad	ORG
admet-337	754	1	sci. u.s.a.	ORG
admet-337	755	1	104	CARDINAL
admet-337	755	2	2007	DATE
admet-337	755	3	20932-20937	DATE
admet-337	756	1	55	CARDINAL
admet-337	756	2	m.j.	PERSON
admet-337	756	3	niederst, j.k.	ORG
admet-337	756	4	lennerz	PERSON
admet-337	756	5	j. thorac	PERSON
admet-337	757	1	oncol.	DATE
admet-337	758	1	11	CARDINAL
admet-337	758	2	2016	DATE
admet-337	759	1	grace dy et	PERSON
admet-337	759	2	al. admet	ORG
admet-337	759	3	4(3	CARDINAL
admet-337	759	4	2016	CARDINAL
admet-337	759	5	186	CARDINAL
admet-337	759	6	56	CARDINAL
admet-337	759	7	cohen	PERSON
admet-337	759	8	g.a. williams	PERSON
admet-337	759	9	r. sridhara	PERSON
admet-337	760	1	clin	PERSON
admet-337	762	1	10 (2004	DATE
admet-337	762	2	1212	CARDINAL
admet-337	763	1	57	CARDINAL
admet-337	763	2	m.g. kris	PERSON
admet-337	763	3	r.b. natale	PERSON
admet-337	763	4	r.s. herbst	PERSON
admet-337	763	5	jama 290	PERSON
admet-337	763	6	2003	DATE
admet-337	763	7	2149-2158	CARDINAL
admet-337	764	1	58	CARDINAL
admet-337	764	2	y.l. wu	PERSON
admet-337	764	3	s. thongprasert	PERSON
admet-337	765	1	j. med	PERSON
admet-337	766	1	361	CARDINAL
admet-337	766	2	2009	DATE
admet-337	766	3	947	CARDINAL
admet-337	767	1	59	CARDINAL
admet-337	767	2	s. morita	PERSON
admet-337	769	1	11	CARDINAL
admet-337	769	2	2010	DATE
admet-337	769	3	121	CARDINAL
admet-337	770	1	60	CARDINAL
admet-337	770	2	m. maemondo, a. inoue	PERSON
admet-337	770	3	k. kobayashi	PERSON
admet-337	771	1	j. med	PERSON
admet-337	772	1	362	CARDINAL
admet-337	772	2	2010	DATE
admet-337	772	3	2380-2388	QUANTITY
admet-337	773	1	61	CARDINAL
admet-337	773	2	han	NORP
admet-337	773	3	k. park	GPE
admet-337	773	4	s.w	GPE
admet-337	773	5	kim	PERSON
admet-337	774	1	j. clin	PERSON
admet-337	775	1	oncol.	DATE
admet-337	776	1	30	CARDINAL
admet-337	776	2	2012	DATE
admet-337	776	3	1122-1128	CARDINAL
admet-337	777	1	62	CARDINAL
admet-337	777	2	s. hong	PERSON
admet-337	777	3	n. li	PERSON
admet-337	777	4	sci.	ORG
admet-337	777	5	5 (	PERCENT
admet-337	777	6	2015) 10648	DATE
admet-337	778	1	63	CARDINAL
admet-337	778	2	m. fukuoka	PERSON
admet-337	778	3	s. yano	PERSON
admet-337	778	4	g. giaccone	PERSON
admet-337	779	1	j. clin	PERSON
admet-337	780	1	oncol.	DATE
admet-337	781	1	2003	DATE
admet-337	781	2	2237	CARDINAL
admet-337	782	1	64	CARDINAL
admet-337	782	2	douillard	PERSON
admet-337	782	3	m. cobo	PERSON
admet-337	784	1	j. cancer	PERSON
admet-337	785	1	110	CARDINAL
admet-337	785	2	2014	DATE
admet-337	785	3	55	CARDINAL
admet-337	786	1	65	CARDINAL
admet-337	786	2	a. laight	PERSON
admet-337	786	3	l. stafford	PERSON
admet-337	787	1	clin	PERSON
admet-337	788	1	pharmacokinet	PERSON
admet-337	789	1	40 (2001	DATE
admet-337	789	2	297	CARDINAL
admet-337	790	1	66	CARDINAL
admet-337	790	2	h.c.	GPE
admet-337	790	3	r.p. smith	ORG
admet-337	790	4	a. laight	PERSON
admet-337	791	1	clin	PERSON
admet-337	792	1	pharmacokinet	PERSON
admet-337	793	1	44 (2005	DATE
admet-337	793	2	1165-1177	CARDINAL
admet-337	794	1	67	CARDINAL
admet-337	794	2	j. li	PERSON
admet-337	794	3	j. brahmer	PERSON
admet-337	794	4	w. messersmith	PERSON
admet-337	794	5	m. hidalgo	PERSON
admet-337	794	6	s.d. baker	PERSON
admet-337	796	1	24 (2006	DATE
admet-337	796	2	291	CARDINAL
admet-337	797	1	68	CARDINAL
admet-337	797	2	a.d. mccormick	PERSON
admet-337	797	3	a. millar	PERSON
admet-337	797	4	g.s. miles	PERSON
admet-337	797	5	p.j. phillips	ORG
admet-337	797	6	35 (2005	DATE
admet-337	797	7	39	CARDINAL
admet-337	798	1	69	CARDINAL
admet-337	798	2	s.p.	GPE
admet-337	798	3	m.p. spence	ORG
admet-337	799	1	xenobiotica 36 (	FAC
admet-337	799	2	29	CARDINAL
admet-337	800	1	70	CARDINAL
admet-337	800	2	k. masago	PERSON
admet-337	800	3	s. masuda	PERSON
admet-337	803	1	70	CARDINAL
admet-337	803	2	2012	DATE
admet-337	803	3	399	CARDINAL
admet-337	804	1	71	CARDINAL
admet-337	804	2	a.j. holmes	PERSON
admet-337	804	3	n. lindeman	PERSON
admet-337	805	1	j. clin	PERSON
admet-337	806	1	oncol.	DATE
admet-337	807	1	24 (2006	DATE
admet-337	808	1	72	CARDINAL
admet-337	808	2	s. kobayashi	PERSON
admet-337	808	3	t.j. boggon	PERSON
admet-337	808	4	t. dayaram	PERSON
admet-337	809	1	j. med	PERSON
admet-337	810	1	352	CARDINAL
admet-337	810	2	2005	DATE
admet-337	810	3	786	CARDINAL
admet-337	811	1	73	CARDINAL
admet-337	811	2	j.a. engelman	ORG
admet-337	811	3	k. zejnullahu	PERSON
admet-337	811	4	t. mitsudomi	GPE
admet-337	811	5	316	DATE
admet-337	811	6	2007	DATE
admet-337	811	7	1039-1043	CARDINAL
admet-337	812	1	74	CARDINAL
admet-337	812	2	l.v.	ORG
admet-337	812	3	j.c. yang	PERSON
admet-337	812	4	n. yamamoto	PERSON
admet-337	812	5	j. clin	PERSON
admet-337	813	1	oncol.	DATE
admet-337	814	1	2013	DATE
admet-337	814	2	3327-3334	CARDINAL
admet-337	815	1	75	CARDINAL
admet-337	815	2	wu	PERSON
admet-337	815	3	c. zhou	PERSON
admet-337	815	4	c.p. hu	PERSON
admet-337	817	1	15	CARDINAL
admet-337	817	2	2014	DATE
admet-337	817	3	213	CARDINAL
admet-337	818	1	76	CARDINAL
admet-337	818	2	yang	PERSON
admet-337	818	3	y.l. wu	PERSON
admet-337	818	4	m. schuler	PERSON
admet-337	819	1	16	CARDINAL
admet-337	819	2	2015	CARDINAL
admet-337	819	3	141	CARDINAL
admet-337	820	1	77	CARDINAL
admet-337	820	2	k. park	PERSON
admet-337	820	3	k. o'byrne	PERSON
admet-337	822	1	17	CARDINAL
admet-337	822	2	2016	CARDINAL
admet-337	822	3	577	CARDINAL
admet-337	823	1	soria	PERSON
admet-337	823	2	e. felip	PERSON
admet-337	823	3	m. cobo	PERSON
admet-337	825	1	16	CARDINAL
admet-337	825	2	897	CARDINAL
admet-337	826	1	79	CARDINAL
admet-337	826	2	n. katakami	PERSON
admet-337	826	3	s. atagi	PERSON
admet-337	826	4	k. goto	PERSON
admet-337	827	1	j. clin	PERSON
admet-337	828	1	oncol.	DATE
admet-337	829	1	2013	DATE
admet-337	829	2	3335-3341	CARDINAL
admet-337	830	1	80	CARDINAL
admet-337	830	2	y.y. janjigian	PERSON
admet-337	830	3	e.f. smit	GPE
admet-337	832	1	4 (2014	DATE
admet-337	832	2	1036	CARDINAL
admet-337	833	1	81	CARDINAL
admet-337	833	2	f. solca	PERSON
admet-337	833	3	g. dahl	PERSON
admet-337	833	4	a. zoephel	PERSON
admet-337	834	1	j. pharmacol	ORG
admet-337	837	1	343	CARDINAL
admet-337	837	2	2012	DATE
admet-337	837	3	342	CARDINAL
admet-337	838	1	82	CARDINAL
admet-337	838	2	d. li	PERSON
admet-337	838	3	l. ambrogio	PERSON
admet-337	838	4	t. shimamura	PERSON
admet-337	838	5	27 (2008) 4702-4711	DATE
admet-337	839	1	83	CARDINAL
admet-337	839	2	s. wind	PERSON
admet-337	839	3	m. schmid	PERSON
admet-337	839	4	j. erhardt	PERSON
admet-337	839	5	r.g.	GPE
admet-337	839	6	clin	PERSON
admet-337	840	1	52	CARDINAL
admet-337	840	2	1101-1109	DATE
admet-337	841	1	84	CARDINAL
admet-337	841	2	k. marzin	PERSON
admet-337	841	3	h. narjes	PERSON
admet-337	843	1	69	CARDINAL
admet-337	843	2	2012	DATE
admet-337	843	3	1051-1061	CARDINAL
admet-337	844	1	85	CARDINAL
admet-337	844	2	t. giessmann	GPE
admet-337	844	3	a. jungnik	PERSON
admet-337	845	1	clin	PERSON
admet-337	847	1	34	CARDINAL
admet-337	847	2	2014	DATE
admet-337	847	3	173	CARDINAL
admet-337	848	1	86	CARDINAL
admet-337	848	2	a. tufman	PERSON
admet-337	848	3	t. wehler	PERSON
admet-337	849	1	j. thorac	PERSON
admet-337	850	1	oncol.	DATE
admet-337	851	1	10 (	PERCENT
admet-337	851	2	156	CARDINAL
admet-337	852	1	87	CARDINAL
admet-337	852	2	wu	PERSON
admet-337	852	3	y.n. liu	PERSON
admet-337	852	4	m.f. tsai	PERSON
admet-337	853	1	7	CARDINAL
admet-337	853	2	12404-12413	DATE
admet-337	854	1	88	CARDINAL
admet-337	854	2	kim	PERSON
admet-337	854	3	o.j. kwon	PERSON
admet-337	854	4	y.k.	GPE
admet-337	854	5	hong	GPE
admet-337	856	1	11	CARDINAL
admet-337	856	2	2012	DATE
admet-337	856	3	2254	CARDINAL
admet-337	857	1	89	CARDINAL
admet-337	857	2	k. azuma	PERSON
admet-337	857	3	a. kawahara	PERSON
admet-337	857	4	k. sonoda	PERSON
admet-337	858	1	5	CARDINAL
admet-337	859	1	90	CARDINAL
admet-337	859	2	s. huang	PERSON
admet-337	859	3	s. benavente	PERSON
admet-337	859	4	e.a. armstrong, c. li	PERSON
admet-337	859	5	d.l. wheeler	PERSON
admet-337	860	1	71 (2011) 70717079	DATE
admet-337	861	1	91	CARDINAL
admet-337	861	2	s.e. ashton	GPE
admet-337	861	3	s. ghiorghiu	PERSON
admet-337	862	1	4 (2014	DATE
admet-337	862	2	1046-1061	CARDINAL
admet-337	863	1	92	CARDINAL
admet-337	863	2	r. lawrence	PERSON
admet-337	864	1	j. thorac	PERSON
admet-337	865	1	oncol.	DATE
admet-337	866	1	10 (	PERCENT
admet-337	867	1	93	CARDINAL
admet-337	867	2	j. yang	PERSON
admet-337	867	3	s.s.	PERSON
admet-337	867	4	ramalingam	GPE
admet-337	867	5	p.a. janne	GPE
admet-337	867	6	m. cantarini	PERSON
admet-337	867	7	t. mitsudomi	GPE
admet-337	867	8	j. thorac	PERSON
admet-337	868	1	oncol.	DATE
admet-337	869	1	11	CARDINAL
admet-337	869	2	2016	DATE
admet-337	871	1	94	CARDINAL
admet-337	871	2	76	CARDINAL
admet-337	871	3	2016	CARDINAL
admet-337	871	4	263	CARDINAL
admet-337	872	1	95	CARDINAL
admet-337	872	2	k.h. brown	PERSON
admet-337	872	3	kim	PERSON
admet-337	873	1	77	CARDINAL
admet-337	873	2	2016	CARDINAL
admet-337	873	3	767	CARDINAL
admet-337	874	1	96	CARDINAL
admet-337	874	2	b. ricciuti	PERSON
admet-337	874	3	r. chiari	PERSON
admet-337	875	1	clin	PERSON
admet-337	876	1	2016	CARDINAL
admet-337	876	2	683	CARDINAL
admet-337	877	1	4(3	CARDINAL
admet-337	877	2	2016	CARDINAL
admet-337	877	3	186	CARDINAL
admet-337	877	4	10.5599	CARDINAL
admet-337	877	5	209	CARDINAL
admet-337	877	6	97	CARDINAL
admet-337	877	7	yang	PERSON
admet-337	877	8	d.w.	PERSON
admet-337	878	1	kim	PERSON
admet-337	878	2	s.w	GPE
admet-337	878	3	kim	PERSON
admet-337	879	1	american	NORP
admet-337	879	2	annual	DATE
admet-337	879	3	2016	DATE
admet-337	880	1	98	CARDINAL
admet-337	880	2	tian	GPE
admet-337	880	3	a.e.	PERSON
admet-337	880	4	jama oncol	PERSON
admet-337	881	1	1 (	CARDINAL
admet-337	881	2	982	CARDINAL
admet-337	882	1	99	CARDINAL
admet-337	882	2	c.p.	GPE
admet-337	882	3	e. felip	PERSON
admet-337	882	4	nat	PERSON
admet-337	884	1	21	CARDINAL
admet-337	884	2	2015	CARDINAL
admet-337	884	3	560	CARDINAL
admet-337	885	1	100	CARDINAL
admet-337	885	2	c.a. eberlein	PERSON
admet-337	885	3	d. stetson	PERSON
admet-337	885	4	a.a.	GPE
admet-337	886	1	75 (	PERCENT
admet-337	886	2	2489	CARDINAL
admet-337	887	1	101	CARDINAL
admet-337	887	2	k. park	GPE
admet-337	887	3	j.s. lee	PERSON
admet-337	887	4	j.y.	GPE
admet-337	887	5	han	NORP
admet-337	888	1	j. thorac	PERSON
admet-337	890	1	2016;11	CARDINAL
admet-337	890	2	s113-0864(16)30243-x.	PRODUCT
admet-337	890	3	2016	CARDINAL
admet-337	891	1	102	CARDINAL
admet-337	891	2	k. park	GPE
admet-337	891	3	j.y.	GPE
admet-337	891	4	han	NORP
admet-337	891	5	d.w. kim	PERSON
admet-337	892	1	j. thorac	PERSON
admet-337	894	1	2016;11	CARDINAL
admet-337	895	1	2016	CARDINAL
admet-337	896	1	103	CARDINAL
admet-337	896	2	a. spira	PERSON
admet-337	896	3	l. horn	GPE
admet-337	896	4	asp8273 300 mg	PRODUCT
admet-337	896	5	1	CARDINAL
admet-337	897	1	american	NORP
admet-337	897	2	annual	DATE
admet-337	897	3	2016	DATE
admet-337	898	1	104	CARDINAL
admet-337	898	2	j.c. yang	PERSON
admet-337	898	3	n. leighl	PERSON
admet-337	898	4	1	CARDINAL
admet-337	898	5	third	ORDINAL
admet-337	898	6	m. american	PERSON
admet-337	898	7	annual	DATE
admet-337	898	8	2016	DATE
admet-337	899	1	105	CARDINAL
admet-337	899	2	q. zhou	PERSON
admet-337	899	3	b. gan	PERSON
admet-337	899	4	l. yuan	PERSON
admet-337	900	1	egfr tki epitinib	PRODUCT
admet-337	900	2	egfrm+	GPE
admet-337	901	1	american	NORP
admet-337	901	2	annual	DATE
admet-337	901	3	2016	DATE
admet-337	902	1	106	CARDINAL
admet-337	903	1	kim	PERSON
admet-337	903	2	j.c. yang	PERSON
admet-337	903	3	k. chen	PERSON
admet-337	903	4	bbb	ORG
admet-337	904	1	american	NORP
admet-337	904	2	annual	DATE
admet-337	904	3	2015	DATE
admet-337	905	1	107	CARDINAL
admet-337	905	2	s. liu	PERSON
admet-337	905	3	c. aggarwal	PERSON
admet-337	905	4	c. brzezniak	PERSON
admet-337	905	5	2	CARDINAL
admet-337	905	6	american	NORP
admet-337	905	7	annual	DATE
admet-337	905	8	2016	DATE
admet-337	906	1	108	CARDINAL
admet-337	906	2	k. rikova	PERSON
admet-337	906	3	a. guo	PERSON
admet-337	906	4	q. zeng	PERSON
admet-337	906	5	131	CARDINAL
admet-337	906	6	2007	DATE
admet-337	906	7	1190-1203	DATE
admet-337	907	1	109	CARDINAL
admet-337	907	2	h. balke-want	PERSON
admet-337	907	3	f. malchers	PERSON
admet-337	907	4	clin	PERSON
admet-337	909	1	18	CARDINAL
admet-337	909	2	2012	DATE
admet-337	909	3	4682	CARDINAL
admet-337	910	1	110	CARDINAL
admet-337	910	2	r. bayliss	PERSON
admet-337	910	3	j. choi	PERSON
admet-337	910	4	d.a. fennell	PERSON
admet-337	910	5	richards mw	PERSON
admet-337	910	6	sci	ORG
admet-337	911	1	73	CARDINAL
admet-337	911	2	2016	CARDINAL
admet-337	911	3	1209	CARDINAL
admet-337	912	1	111	CARDINAL
admet-337	912	2	shaw	PERSON
admet-337	912	3	b. solomon	PERSON
admet-337	912	4	clin	PERSON
admet-337	914	1	17 (2011	DATE
admet-337	914	2	2081	CARDINAL
admet-337	915	1	112	CARDINAL
admet-337	915	2	kwak	GPE
admet-337	915	3	y.j	GPE
admet-337	915	4	bang	GPE
admet-337	915	5	d.r.	GPE
admet-337	916	1	j. med	PERSON
admet-337	917	1	363	CARDINAL
admet-337	917	2	2010	DATE
admet-337	917	3	1693-1703	DATE
admet-337	918	1	113	CARDINAL
admet-337	918	2	d.r. camidge	GPE
admet-337	918	3	y.j	GPE
admet-337	918	4	kwak	PERSON
admet-337	919	1	13	CARDINAL
admet-337	919	2	2012	DATE
admet-337	919	3	1011-1019	DATE
admet-337	920	1	114	CARDINAL
admet-337	920	2	d.w. kim	PERSON
admet-337	920	3	g.j.	GPE
admet-337	920	4	riely	GPE
admet-337	921	1	1005	DATE
admet-337	922	1	american	NORP
admet-337	922	2	annual	DATE
admet-337	922	3	2011	DATE
admet-337	923	1	115	CARDINAL
admet-337	923	2	shaw	ORG
admet-337	923	3	d.w. kim	PERSON
admet-337	923	4	k. nakagawa	PERSON
admet-337	924	1	j. med	PERSON
admet-337	925	1	368	CARDINAL
admet-337	925	2	2013	DATE
admet-337	925	3	2385-2394	DATE
admet-337	926	1	116	CARDINAL
admet-337	926	2	solomon	PERSON
admet-337	926	3	t. mok	PERSON
admet-337	926	4	d.w.	PERSON
admet-337	927	1	kim	PERSON
admet-337	928	1	j. med	PERSON
admet-337	929	1	371	CARDINAL
admet-337	929	2	2014	DATE
admet-337	929	3	2167-2177	DATE
admet-337	930	1	117	CARDINAL
admet-337	930	2	r. salgia	PERSON
admet-337	930	3	b.j	GPE
admet-337	930	4	solomon	PERSON
admet-337	930	5	a.t. shaw	PERSON
admet-337	931	1	alk)-positive	NORP
admet-337	932	1	american	NORP
admet-337	932	2	annual	DATE
admet-337	932	3	2012	DATE
admet-337	933	1	118	CARDINAL
admet-337	933	2	weickhardt	PERSON
admet-337	933	3	r.c.	PERSON
admet-337	933	4	w.t. purcell	PERSON
admet-337	933	5	119	CARDINAL
admet-337	933	6	2013	DATE
admet-337	933	7	2383-2390	DATE
admet-337	934	1	119	CARDINAL
admet-337	934	2	i. okamoto	PERSON
admet-337	934	3	m. miyazaki	PERSON
admet-337	934	4	s. shimizu	PERSON
admet-337	934	5	m. kitaichi	PERSON
admet-337	934	6	k. nakagawa	PERSON
admet-337	934	7	j. clin	PERSON
admet-337	935	1	oncol.	DATE
admet-337	936	1	2013	DATE
admet-337	937	1	120	CARDINAL
admet-337	937	2	w.p. tong	PERSON
admet-337	937	3	m. azada	PERSON
admet-337	937	4	c. siwak-tapp	PERSON
admet-337	937	5	j. dy	PERSON
admet-337	937	6	j.a.	PERSON
admet-337	937	7	stiber	DATE
admet-337	937	8	119	CARDINAL
admet-337	937	9	2013) 1969-1975	DATE
admet-337	938	1	121	CARDINAL
admet-337	938	2	q. li	PERSON
admet-337	938	3	j.h. lee	PERSON
admet-337	940	1	67	CARDINAL
admet-337	940	2	2007	DATE
admet-337	940	3	4408-4417	DATE
admet-337	941	1	122	CARDINAL
admet-337	941	2	christensen	PERSON
admet-337	941	3	h.y. zou	PERSON
admet-337	941	4	m.e. arango	ORG
admet-337	943	1	6 (	PERCENT
admet-337	943	2	2007	DATE
admet-337	944	1	123	CARDINAL
admet-337	944	2	m. tran-dube	PERSON
admet-337	944	3	h. shen	PERSON
admet-337	944	4	j. med	PERSON
admet-337	945	1	54 (2011) 6342-6363	DATE
admet-337	946	1	124	CARDINAL
admet-337	946	2	a.j.	PERSON
admet-337	946	3	iafrate	ORG
admet-337	946	4	n.s.	GPE
admet-337	948	1	68	CARDINAL
admet-337	948	2	3389	CARDINAL
admet-337	949	1	125	CARDINAL
admet-337	949	2	d.b. costa	ORG
admet-337	949	3	s. kobayashi	PERSON
admet-337	949	4	s.s. pandya	PERSON
admet-337	950	1	j. clin	PERSON
admet-337	951	1	oncol.	DATE
admet-337	952	1	29 (2011	DATE
admet-337	953	1	e443-5	CARDINAL
admet-337	954	1	grace dy et	PERSON
admet-337	954	2	al. admet	ORG
admet-337	954	3	4(3	CARDINAL
admet-337	954	4	2016	CARDINAL
admet-337	954	5	186	CARDINAL
admet-337	955	1	126	CARDINAL
admet-337	955	2	crizotinib	PERSON
admet-337	957	1	new york	GPE
admet-337	957	2	ny: pfizer inc.	ORG
admet-337	957	3	2012	DATE
admet-337	958	1	127	CARDINAL
admet-337	958	2	m.p. curran	PERSON
admet-337	958	3	72	CARDINAL
admet-337	958	4	2012	DATE
admet-337	958	5	99	CARDINAL
admet-337	959	1	128	CARDINAL
admet-337	959	2	c. li	PERSON
admet-337	959	3	c. alvey	PERSON
admet-337	959	4	a. bello	PERSON
admet-337	959	5	k.d.	GPE
admet-337	959	6	wilner	PERSON
admet-337	959	7	w. tan	PERSON
admet-337	960	1	pharmacokinetics	PERSON
admet-337	961	1	american	NORP
admet-337	961	2	annual	DATE
admet-337	961	3	2011	DATE
admet-337	962	1	129	CARDINAL
admet-337	962	2	g. lunardi	PERSON
admet-337	963	1	j. thorac	PERSON
admet-337	964	1	oncol.	DATE
admet-337	965	1	10 (	PERCENT
admet-337	965	2	e26	CARDINAL
admet-337	966	1	130	CARDINAL
admet-337	966	2	costa	GPE
admet-337	966	3	a.t. shaw	PERSON
admet-337	966	4	s.h. ou	PERSON
admet-337	967	1	j. clin	PERSON
admet-337	968	1	oncol.	DATE
admet-337	969	1	33	CARDINAL
admet-337	969	2	1881-1888	DATE
admet-337	970	1	131	CARDINAL
admet-337	970	2	y.l. choi	GPE
admet-337	970	3	m. soda	PERSON
admet-337	970	4	y. yamashita	ORG
admet-337	971	1	j. med	PERSON
admet-337	972	1	363	CARDINAL
admet-337	972	2	2010	DATE
admet-337	972	3	1734-1739	DATE
admet-337	973	1	132	CARDINAL
admet-337	973	2	a.b.	GPE
admet-337	973	3	d.l. aisner	ORG
admet-337	974	1	clin	PERSON
admet-337	976	1	18	CARDINAL
admet-337	976	2	2012	DATE
admet-337	976	3	1472-1482	CARDINAL
admet-337	977	1	133	CARDINAL
admet-337	977	2	t. sasaki	GPE
admet-337	977	3	j. koivunen	PERSON
admet-337	977	4	a. ogino	PERSON
admet-337	978	1	71 (2011) 6051-6060	DATE
admet-337	979	1	134	CARDINAL
admet-337	979	2	s. kim	PERSON
admet-337	979	3	kim	PERSON
admet-337	979	4	d.w. kim	PERSON
admet-337	980	1	j. thorac	PERSON
admet-337	982	1	8 (2013	DATE
admet-337	982	2	415	CARDINAL
admet-337	983	1	135	CARDINAL
admet-337	983	2	d. huang	PERSON
admet-337	983	3	d.w. kim	PERSON
admet-337	983	4	a. kotsakis	PERSON
admet-337	983	5	102	CARDINAL
admet-337	983	6	2013	DATE
admet-337	983	7	157	CARDINAL
admet-337	984	1	136	CARDINAL
admet-337	984	2	l. friboulet	PERSON
admet-337	984	3	n. li	PERSON
admet-337	984	4	r. katayama	PERSON
admet-337	986	1	4 (2014	DATE
admet-337	986	2	662	CARDINAL
admet-337	987	1	137	CARDINAL
admet-337	987	2	ignatius ou	PERSON
admet-337	987	3	m. azada	PERSON
admet-337	987	4	d.j. hsiang	PERSON
admet-337	988	1	j. thorac	PERSON
admet-337	989	1	oncol.	DATE
admet-337	990	1	2014	DATE
admet-337	990	2	549	CARDINAL
admet-337	991	1	138	CARDINAL
admet-337	991	2	j. sang	PERSON
admet-337	991	3	j. acquaviva	PERSON
admet-337	991	4	j.c. friedland	PERSON
admet-337	993	1	3 (2013	DATE
admet-337	993	2	430	CARDINAL
admet-337	994	1	139	CARDINAL
admet-337	994	2	n.t. mcdonald	PERSON
admet-337	994	3	h. chen	PERSON
admet-337	995	1	nat	PERSON
admet-337	997	1	20 (2014	DATE
admet-337	997	2	1027-1034	CARDINAL
admet-337	998	1	140	CARDINAL
admet-337	998	2	e. felip	PERSON
admet-337	998	3	s. orlov	PERSON
admet-337	998	4	k. park	PERSON
admet-337	998	5	2014	DATE
admet-337	999	1	141	CARDINAL
admet-337	999	2	d.r.	GPE
admet-337	999	3	a.t. shaw	PERSON
admet-337	999	4	ascend-2	PERSON
admet-337	1000	1	american	NORP
admet-337	1000	2	annual	DATE
admet-337	1000	3	2015	DATE
admet-337	1001	1	142	CARDINAL
admet-337	1001	2	e. felip	PERSON
admet-337	1001	3	s. orlov	PERSON
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admet-337	1002	1	ascend-3	PERSON
admet-337	1003	1	american	NORP
admet-337	1003	2	annual	DATE
admet-337	1003	3	2015	DATE
admet-337	1004	1	143	CARDINAL
admet-337	1006	1	east hanover	GPE
admet-337	1006	2	nj	ORG
admet-337	1006	3	2014	DATE
admet-337	1007	1	144	CARDINAL
admet-337	1007	2	w. pei	PERSON
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admet-337	1008	1	j. med	PERSON
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admet-337	1009	2	2013	DATE
admet-337	1009	3	5675	CARDINAL
admet-337	1010	1	145	CARDINAL
admet-337	1010	2	l. friboulet	PERSON
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admet-337	1011	2	annual	DATE
admet-337	1011	3	2014	DATE
admet-337	1012	1	146	CARDINAL
admet-337	1012	2	t. kodama	PERSON
admet-337	1012	3	t. tsukaguchi	GPE
admet-337	1012	4	m. yoshida	PERSON
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admet-337	1013	1	351	CARDINAL
admet-337	1013	2	2014	DATE
admet-337	1013	3	215	CARDINAL
admet-337	1014	1	147	CARDINAL
admet-337	1014	2	h. sakamoto	PERSON
admet-337	1014	3	t. tsukaguchi	GPE
admet-337	1014	4	s. hiroshima	PERSON
admet-337	1015	1	19 (2011	DATE
admet-337	1015	2	679	CARDINAL
admet-337	1016	1	148	CARDINAL
admet-337	1016	2	k. kiura	PERSON
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admet-337	1018	2	590	CARDINAL
admet-337	1019	1	149	CARDINAL
admet-337	1019	2	gadgeel	PERSON
admet-337	1019	3	l. gandhi	PERSON
admet-337	1019	4	g.j.	GPE
admet-337	1021	1	15	CARDINAL
admet-337	1021	2	1119-1128	DATE
admet-337	1022	1	150	CARDINAL
admet-337	1022	2	shaw	PERSON
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admet-337	1024	3	234	CARDINAL
admet-337	1025	1	151	CARDINAL
admet-337	1025	2	t. hida	PERSON
admet-337	1025	3	m. kondo	PERSON
admet-337	1025	4	alectinib	PERSON
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admet-337	1026	1	american	NORP
admet-337	1026	2	annual	DATE
admet-337	1026	3	2016	DATE
admet-337	1027	1	152	CARDINAL
admet-337	1027	2	k. kinoshita	PERSON
admet-337	1027	3	k. asoh	PERSON
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admet-337	1029	1	20	CARDINAL
admet-337	1029	2	2012	DATE
admet-337	1029	3	1271-1280	CARDINAL
admet-337	1030	1	153	CARDINAL
admet-337	1030	2	t. kodama	PERSON
admet-337	1030	3	t. tsukaguchi	GPE
admet-337	1030	4	y. satoh	PERSON
admet-337	1033	1	13	CARDINAL
admet-337	1033	2	2014	DATE
admet-337	1034	1	154	CARDINAL
admet-337	1036	1	basel	GPE
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admet-337	1036	3	roche	ORG
admet-337	1036	4	2015	DATE
admet-337	1037	1	155	CARDINAL
admet-337	1037	2	r. katayama	PERSON
admet-337	1037	3	l. friboulet	PERSON
admet-337	1037	4	s. koike	PERSON
admet-337	1037	5	clin	PERSON
admet-337	1039	1	20 (2014	DATE
admet-337	1039	2	5686-5696	DATE
admet-337	1040	1	156	CARDINAL
admet-337	1040	2	s. takashi	PERSON
admet-337	1040	3	t. mitsuhiro	GPE
admet-337	1040	4	i. yukito	PERSON
admet-337	1040	5	j.t horac	PERSON
admet-337	1041	1	oncol.	DATE
admet-337	1043	1	157	CARDINAL
admet-337	1043	2	l. friboulet	PERSON
admet-337	1043	3	d.p. kodack	GPE
admet-337	1045	1	28	CARDINAL
admet-337	1045	2	70-81	CARDINAL
admet-337	1046	1	158	CARDINAL
admet-337	1046	2	m. ceccon	PERSON
admet-337	1046	3	c. gambacorti-passerini	PERSON
admet-337	1046	4	l. mologni	PERSON
admet-337	1047	1	4 (2015	CARDINAL
admet-337	1047	2	953	CARDINAL
admet-337	1048	1	4(3	CARDINAL
admet-337	1048	2	2016	CARDINAL
admet-337	1048	3	186	CARDINAL
admet-337	1048	4	10.5599	CARDINAL
admet-337	1048	5	211	CARDINAL
admet-337	1048	6	159	CARDINAL
admet-337	1048	7	hatcher	PERSON
admet-337	1048	8	m. bahcall	PERSON
admet-337	1048	9	h.g.	GPE
admet-337	1049	1	j. med	PERSON
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admet-337	1050	2	2015	CARDINAL
admet-337	1051	1	160	CARDINAL
admet-337	1051	2	shaw	PERSON
admet-337	1051	3	l. friboulet	PERSON
admet-337	1051	4	i. leshchiner	PERSON
admet-337	1052	1	j. med	PERSON
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admet-337	1053	2	2016	CARDINAL
admet-337	1053	3	54	CARDINAL
admet-337	1054	1	161	CARDINAL
admet-337	1054	2	huang	PERSON
admet-337	1054	3	s. liu	PERSON
admet-337	1054	4	d. zou	PERSON
admet-337	1054	5	j. med	PERSON
admet-337	1055	1	59	CARDINAL
admet-337	1055	2	2016	CARDINAL
admet-337	1055	3	4948-4964	DATE
admet-337	1056	1	162	CARDINAL
admet-337	1056	2	kim	PERSON
admet-337	1056	3	m. tiseo	PERSON
admet-337	1056	4	m.j. ahn	PERSON
admet-337	1056	5	crz)-refractory	NORP
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admet-337	1056	7	2	CARDINAL
admet-337	1057	1	american	NORP
admet-337	1057	2	annual	DATE
admet-337	1057	3	2016	DATE
admet-337	1058	1	163	CARDINAL
admet-337	1058	2	l.a.	GPE
admet-337	1058	3	bazhenova	GPE
admet-337	1058	4	r. salgia	PERSON
admet-337	1058	5	first	ORDINAL
admet-337	1059	1	american	NORP
admet-337	1059	2	annual	DATE
admet-337	1059	3	2013	DATE
admet-337	1060	1	164	CARDINAL
admet-337	1060	2	solomon	PERSON
admet-337	1060	3	e. felip	PERSON
admet-337	1061	1	american	NORP
admet-337	1061	2	annual	DATE
admet-337	1061	3	2016	DATE
admet-337	1062	1	165	CARDINAL
admet-337	1062	2	j. infante	PERSON
admet-337	1062	3	g.r.	PERSON
admet-337	1063	1	x-396	DATE
admet-337	1064	1	american	NORP
admet-337	1064	2	annual	DATE
admet-337	1064	3	2014	DATE
admet-337	1065	1	166	CARDINAL
admet-337	1065	2	m. maitland	PERSON
admet-337	1065	3	s.h. ou,	PERSON
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admet-337	1065	5	1	CARDINAL
admet-337	1066	1	american	NORP
admet-337	1066	2	annual	DATE
admet-337	1066	3	2014	DATE
admet-337	1067	1	167	CARDINAL
admet-337	1067	2	a. vaishnavi	PERSON
admet-337	1067	3	m. capelletti	PERSON
admet-337	1067	4	a.t. le	ORG
admet-337	1068	1	nat	PERSON
admet-337	1070	1	19	CARDINAL
admet-337	1070	2	1469-1472	DATE
admet-337	1071	1	168	CARDINAL
admet-337	1071	2	j.c. sachdev	PERSON
admet-337	1071	3	m.m.	PERSON
admet-337	1071	4	1/2a	DATE
admet-337	1071	5	alk	ORG
admet-337	1072	1	american	NORP
admet-337	1072	2	annual	DATE
admet-337	1072	3	2015	DATE
admet-337	1073	1	169	CARDINAL
admet-337	1073	2	f. de braud	PERSON
admet-337	1073	3	m. niger	PERSON
admet-337	1073	4	s. damian	PERSON
admet-337	1073	5	first	ORDINAL
admet-337	1074	1	american	NORP
admet-337	1074	2	annual	DATE
admet-337	1074	3	2016	DATE
admet-337	1075	1	170	CARDINAL
admet-337	1075	2	r. van leeuwen	PERSON
admet-337	1075	3	t. van gelder	PERSON
admet-337	1075	4	r. mathijssen	PERSON
admet-337	1077	1	15	CARDINAL
admet-337	1077	2	2014	DATE
admet-337	1077	3	315	CARDINAL
admet-337	1078	1	171	CARDINAL
admet-337	1078	2	j. brahmer	PERSON
admet-337	1078	3	k. reckamp	PERSON
admet-337	1079	1	j. med	PERSON
admet-337	1080	1	373	CARDINAL
admet-337	1080	2	2015	CARDINAL
admet-337	1080	3	123	CARDINAL
admet-337	1081	1	172	CARDINAL
admet-337	1081	2	h. borghaei	PERSON
admet-337	1081	3	l. paz-ares	PERSON
admet-337	1081	4	l. horn	PERSON
admet-337	1082	1	j. med	PERSON
admet-337	1083	1	373	CARDINAL
admet-337	1083	2	2015	CARDINAL
admet-337	1083	3	1627-39	DATE
admet-337	1084	1	173	CARDINAL
admet-337	1084	2	r. herbst	PERSON
admet-337	1084	3	d. kim	PERSON
admet-337	1085	1	387	CARDINAL
admet-337	1085	2	2016	CARDINAL
admet-337	1085	3	1540-50	DATE
admet-337	1086	1	174	CARDINAL
admet-337	1086	2	s. gettinger	PERSON
admet-337	1086	3	n. rizvi	PERSON
admet-337	1086	4	l. chow	PERSON
admet-337	1087	1	j. clin	PERSON
admet-337	1088	1	oncol.	DATE
admet-337	1089	1	34	CARDINAL
admet-337	1089	2	2016	CARDINAL
admet-337	1089	3	2980	CARDINAL
admet-337	1090	1	175	CARDINAL
admet-337	1090	2	n. rizvi	PERSON
admet-337	1090	3	m. hellmann	PERSON
admet-337	1090	4	j. brahmer	PERSON
admet-337	1091	1	j. clin	PERSON
admet-337	1092	1	oncol.	DATE
admet-337	1093	1	34	CARDINAL
admet-337	1093	2	2016	CARDINAL
admet-337	1093	3	2969	CARDINAL
admet-337	1094	1	176	CARDINAL
admet-337	1094	2	a. snyder	PERSON
admet-337	1094	3	v. marakov	PERSON
admet-337	1095	1	j. med	PERSON
admet-337	1096	1	371	CARDINAL
admet-337	1096	2	2014	DATE
admet-337	1096	3	2189	CARDINAL
admet-337	1097	1	177	CARDINAL
admet-337	1097	2	n. rizvi	PERSON
admet-337	1097	3	m. hellmann	PERSON
admet-337	1097	4	a. snyder	PERSON
admet-337	1097	5	348	CARDINAL
admet-337	1097	6	2015	CARDINAL
admet-337	1097	7	124	CARDINAL
admet-337	1098	1	178	CARDINAL
admet-337	1098	2	e. akbay	PERSON
admet-337	1098	3	s. koyama	PERSON
admet-337	1098	4	j. carretero	PERSON
admet-337	1099	1	3 (2013	DATE
admet-337	1099	2	1355-63	DATE
admet-337	1100	1	179	CARDINAL
admet-337	1100	2	n. chen	PERSON
admet-337	1100	3	w. fang	PERSON
admet-337	1100	4	j. zhan	PERSON
admet-337	1101	1	j. thorac	PERSON
admet-337	1102	1	oncol.	DATE
admet-337	1103	1	10 (	PERCENT
admet-337	1103	2	910	CARDINAL
admet-337	1104	1	180	CARDINAL
admet-337	1104	2	k. ota	PERSON
admet-337	1104	3	k. azuma	PERSON
admet-337	1104	4	a. kawahara	PERSON
admet-337	1105	1	clin	PERSON
admet-337	1107	1	21	CARDINAL
admet-337	1107	2	2015	CARDINAL
admet-337	1107	3	4014-21	DATE
admet-337	1108	1	181	CARDINAL
admet-337	1108	2	s. hong	PERSON
admet-337	1108	3	n. chen	PERSON
admet-337	1108	4	w. fang	PERSON
admet-337	1108	5	5 (	PERCENT
admet-337	1108	6	2015	DATE
admet-337	1109	1	182	CARDINAL
admet-337	1109	2	m. ahn	PERSON
admet-337	1109	3	j. yang	PERSON
admet-337	1109	4	h. yu	PERSON
admet-337	1109	5	durvalumab	PERSON
admet-337	1109	6	tatton	PERSON
admet-337	1110	1	european	NORP
admet-337	1110	2	2016	DATE
admet-337	1111	1	2016	DATE
admet-337	1111	2	iapc	ORG
admet-337	1111	3	zagreb	GPE
admet-337	1111	4	croatia	GPE
admet-337	1112	1	http://creativecommons.org/licenses/by/3.0/	ORG
admet-337	1112	2	http://creativecommons.org/licenses/by/3.0/	ORG