id	sid	eid	entity	type
admet-437	1	1	10.5599	CARDINAL
admet-437	1	2	212	CARDINAL
admet-437	1	3	admet &	ORG
admet-437	1	4	5(4	CARDINAL
admet-437	1	5	2017	CARDINAL
admet-437	1	6	212	CARDINAL
admet-437	1	7	issn	PERSON
admet-437	1	8	1848-7718	DATE
admet-437	1	9	balakrishna1	PERSON
admet-437	1	10	hiremath2	PERSON
admet-437	1	11	sulochana1	ORG
admet-437	1	12	devaraj v chandrasekhar1	PERSON
admet-437	1	13	mohd zainuddin1	PERSON
admet-437	1	14	bhamidipati1	PERSON
admet-437	1	15	1	CARDINAL
admet-437	1	16	jubilant biosys	PERSON
admet-437	1	17	022	CARDINAL
admet-437	1	18	2	CARDINAL
admet-437	1	19	india	GPE
admet-437	1	20	mullangi.ramesh@jubilantinnovation.com	ORG
admet-437	2	1	9611333488	CARDINAL
admet-437	2	2	september 08, 2017	DATE
admet-437	2	3	october 03, 2017	DATE
admet-437	2	4	december 24, 2017	DATE
admet-437	2	5	erk1	ORG
admet-437	3	1	kras-mutant	ORG
admet-437	8	1	2.67	CARDINAL
admet-437	8	2	10 -6 cm	QUANTITY
admet-437	8	3	3.02	CARDINAL
admet-437	10	1	cyps	ORG
admet-437	11	1	between 10-20 µm	CARDINAL
admet-437	12	1	0.50-0.75	MONEY
admet-437	12	2	2	CARDINAL
admet-437	12	3	half	CARDINAL
admet-437	12	4	1.0-2.5	CARDINAL
admet-437	13	1	6.24 ml	QUANTITY
admet-437	13	2	0.56 l/kg	QUANTITY
admet-437	13	3	1.67 ml/min/kg	QUANTITY
admet-437	13	4	0.36 l/kg	QUANTITY
admet-437	13	5	15.5 ml	QUANTITY
admet-437	13	6	1.61 l/kg	QUANTITY
admet-437	14	1	92 %	PERCENT
admet-437	14	2	34 %	PERCENT
admet-437	15	1	erk1	PERSON
admet-437	15	2	erk2	PERSON
admet-437	15	3	the ras/raf/mek	ORG
admet-437	16	1	1	CARDINAL
admet-437	17	1	ras/raf/mek	ORG
admet-437	18	1	2	CARDINAL
admet-437	19	1	mek	ORG
admet-437	19	2	the ras/raf/mek	ORG
admet-437	19	3	3	CARDINAL
admet-437	20	1	about 90 %	PERCENT
admet-437	20	2	50 %	PERCENT
admet-437	20	3	30 %	PERCENT
admet-437	21	1	4	CARDINAL
admet-437	22	1	http://www.pub.iapchem.org/ojs/index.php/admet/index mailto:mullangi.ramesh@jubilantinnovation.com admet	ORG
admet-437	22	2	5(4	CARDINAL
admet-437	22	3	2017	CARDINAL
admet-437	22	4	212	CARDINAL
admet-437	22	5	10.5599	CARDINAL
admet-437	22	6	213	CARDINAL
admet-437	22	7	mek	ORG
admet-437	23	1	1	CARDINAL
admet-437	23	2	first	ORDINAL
admet-437	24	1	vegfr2	PERSON
admet-437	25	1	5	CARDINAL
admet-437	26	1	6	CARDINAL
admet-437	28	1	9	CARDINAL
admet-437	28	2	mtd	ORG
admet-437	28	3	10	CARDINAL
admet-437	29	1	linear	ORG
admet-437	29	2	up to	QUANTITY
admet-437	29	3	600 mg	QUANTITY
admet-437	29	4	mtd	ORG
admet-437	30	1	7	CARDINAL
admet-437	31	1	1	CARDINAL
admet-437	33	1	sprague	GPE
admet-437	33	2	dawley	GPE
admet-437	34	1	99 %	PERCENT
admet-437	34	2	medkoo biosciences, inc.	ORG
admet-437	34	3	nc	GPE
admet-437	34	4	usa	GPE
admet-437	34	5	new delhi	GPE
admet-437	34	6	india	GPE
admet-437	35	1	gibco®	ORG
admet-437	35	2	inchinnan	GPE
admet-437	35	3	uk	GPE
admet-437	35	4	phenacetin	PERSON
admet-437	35	5	nootkatone	ORG
admet-437	35	6	furafylline	ORG
admet-437	35	7	sigma-aldrich chemie gmbh	ORG
admet-437	35	8	steinheim	GPE
admet-437	35	9	germany	GPE
admet-437	37	1	r. mullangi et	PERSON
admet-437	37	2	al. admet &	ORG
admet-437	37	3	5(4	CARDINAL
admet-437	37	4	2017	CARDINAL
admet-437	38	1	212	CARDINAL
admet-437	39	1	0.5 mg	QUANTITY
admet-437	39	2	1 μm	CARDINAL
admet-437	39	3	1 μm	CARDINAL
admet-437	40	1	20	CARDINAL
admet-437	40	2	10 mm	QUANTITY
admet-437	40	3	8	CARDINAL
admet-437	41	1	0	CARDINAL
admet-437	41	2	30 min	TIME
admet-437	41	3	8	CARDINAL
admet-437	42	1	200	CARDINAL
admet-437	42	2	200 ng	QUANTITY
admet-437	42	3	0	CARDINAL
admet-437	42	4	5	DATE
admet-437	42	5	15	DATE
admet-437	43	1	3000	CARDINAL
admet-437	43	2	5424r	DATE
admet-437	43	3	germany	GPE
admet-437	43	4	15 min	DATE
admet-437	45	1	1 million	CARDINAL
admet-437	46	1	100	CARDINAL
admet-437	46	2	0	CARDINAL
admet-437	46	3	30	DATE
admet-437	46	4	60	DATE
admet-437	46	5	120	CARDINAL
admet-437	46	6	180 min	QUANTITY
admet-437	46	7	3 μm	CARDINAL
admet-437	47	1	3 μm	CARDINAL
admet-437	47	2	9	CARDINAL
admet-437	48	1	37 °	QUANTITY
admet-437	48	2	5 min	TIME
admet-437	49	1	200	CARDINAL
admet-437	49	2	200 ng	QUANTITY
admet-437	50	1	3000	CARDINAL
admet-437	50	2	5424r	DATE
admet-437	50	3	germany	GPE
admet-437	50	4	15 min	DATE
admet-437	53	1	24	CARDINAL
admet-437	53	2	millipore	PERSON
admet-437	53	3	billerica	GPE
admet-437	53	4	ma, usa	ORG
admet-437	53	5	80,000	CARDINAL
admet-437	54	1	21 to 22 days	DATE
admet-437	56	1	500 ω cm2	QUANTITY
admet-437	57	1	digoxin	PERSON
admet-437	57	2	5 µm	CARDINAL
admet-437	57	3	10	CARDINAL
admet-437	58	1	10 µm	DATE
admet-437	58	2	0.05 %	PERCENT
admet-437	60	1	11	CARDINAL
admet-437	61	1	100	CARDINAL
admet-437	61	2	0	CARDINAL
admet-437	61	3	60 min	QUANTITY
admet-437	61	4	200 ng	QUANTITY
admet-437	61	5	4000	CARDINAL
admet-437	61	6	5424r	DATE
admet-437	61	7	germany	GPE
admet-437	61	8	10 min	DATE
admet-437	62	1	100	CARDINAL
admet-437	62	2	12	CARDINAL
admet-437	63	1	3 µm	DATE
admet-437	64	1	150	CARDINAL
admet-437	64	2	first half	DATE
admet-437	64	3	96	CARDINAL
admet-437	65	1	150	CARDINAL
admet-437	65	2	100	CARDINAL
admet-437	65	3	mm admet & dmpk	ORG
admet-437	65	4	5(4	CARDINAL
admet-437	65	5	2017	CARDINAL
admet-437	65	6	212	CARDINAL
admet-437	65	7	10.5599	CARDINAL
admet-437	65	8	215	CARDINAL
admet-437	65	9	7.4	CARDINAL
admet-437	65	10	the second half	DATE
admet-437	65	11	96	CARDINAL
admet-437	66	1	37 ± 1 °	QUANTITY
admet-437	66	2	4.5	CARDINAL
admet-437	66	3	120	CARDINAL
admet-437	71	1	gibco®	ORG
admet-437	71	2	inchinnan	GPE
admet-437	71	3	uk	GPE
admet-437	71	4	1a2	CARDINAL
admet-437	71	5	2c9	CARDINAL
admet-437	71	6	2c19	CARDINAL
admet-437	72	1	300	CARDINAL
admet-437	72	2	66.7	CARDINAL
admet-437	72	3	7.4	CARDINAL
admet-437	73	1	0.1	CARDINAL
admet-437	73	2	0.25	CARDINAL
admet-437	73	3	0.5 mg/ml	QUANTITY
admet-437	73	4	cyp1a2	ORG
admet-437	73	5	2c9	CARDINAL
admet-437	73	6	2c19	CARDINAL
admet-437	73	7	10	CARDINAL
admet-437	73	8	0.9	CARDINAL
admet-437	73	9	0.1 %	PERCENT
admet-437	74	1	37 ± 1 °	QUANTITY
admet-437	74	2	5 min	TIME
admet-437	75	1	30	CARDINAL
admet-437	75	2	10 mm	QUANTITY
admet-437	76	1	13	CARDINAL
admet-437	77	1	10 min	TIME
admet-437	77	2	300	CARDINAL
admet-437	78	1	2c9	CARDINAL
admet-437	78	2	2c19	CARDINAL
admet-437	78	3	cyp1a2	ORG
admet-437	79	1	rhcyp	PERSON
admet-437	80	1	cyp1a2	ORG
admet-437	80	2	2b6	CARDINAL
admet-437	80	3	2c9	CARDINAL
admet-437	80	4	2c19	CARDINAL
admet-437	80	5	3a4	CARDINAL
admet-437	80	6	gibco®	ORG
admet-437	80	7	inchinnan	GPE
admet-437	80	8	uk	GPE
admet-437	81	1	0.1 μm	QUANTITY
admet-437	81	2	50	CARDINAL
admet-437	81	3	66.7 mm	QUANTITY
admet-437	81	4	7.4	CARDINAL
admet-437	81	5	1 ml	QUANTITY
admet-437	82	1	20	CARDINAL
admet-437	82	2	180	CARDINAL
admet-437	82	3	0	CARDINAL
admet-437	82	4	5	DATE
admet-437	82	5	15	DATE
admet-437	82	6	30	DATE
admet-437	82	7	60 min	QUANTITY
admet-437	82	8	37 ± 1 °	QUANTITY
admet-437	83	1	200 ng	QUANTITY
admet-437	84	1	3000	CARDINAL
admet-437	84	2	5424r	DATE
admet-437	84	3	germany	GPE
admet-437	84	4	4 °	QUANTITY
admet-437	84	5	20 min	TIME
admet-437	85	1	supernatants	PERSON
admet-437	87	1	control incubations	ORG
admet-437	87	2	15	CARDINAL
admet-437	89	1	tween-80	DATE
admet-437	89	2	0.5 %	PERCENT
admet-437	91	1	this tween-80	DATE
admet-437	92	1	0.5 %	PERCENT
admet-437	93	1	10 mg/ml	QUANTITY
admet-437	94	1	10 ml/kg	QUANTITY
admet-437	96	1	10 %	PERCENT
admet-437	96	2	10 %	PERCENT
admet-437	96	3	r. mullangi et	PERSON
admet-437	96	4	al. admet &	ORG
admet-437	96	5	5(4	CARDINAL
admet-437	96	6	2017	CARDINAL
admet-437	97	1	212	CARDINAL
admet-437	97	2	1:1	CARDINAL
admet-437	97	3	80 %	PERCENT
admet-437	98	1	10 ml/kg	QUANTITY
admet-437	98	2	2 ml/kg	QUANTITY
admet-437	99	1	iaec	ORG
admet-437	100	1	sprague	GPE
admet-437	100	2	dawley rats (~7-8 weeks old	ORG
admet-437	100	3	10 weeks old	DATE
admet-437	100	4	hyderabad	GPE
admet-437	100	5	india	GPE
admet-437	101	1	7 days	DATE
admet-437	101	2	altromin spezialfutter gmbh & co.	ORG
admet-437	103	1	20	CARDINAL
admet-437	103	2	d-32791	ORG
admet-437	103	3	lage	GPE
admet-437	103	4	germany	GPE
admet-437	104	1	4	CARDINAL
admet-437	104	2	12	CARDINAL
admet-437	104	3	sprague	GPE
admet-437	104	4	dawley rats	ORG
admet-437	105	1	2	CARDINAL
admet-437	106	1	iaec	ORG
admet-437	106	2	telangana	GPE
admet-437	106	3	india	GPE
admet-437	107	1	~1.0-1.5 year old	DATE
admet-437	107	2	18-28 °	TIME
admet-437	107	3	30-70 %	PERCENT
admet-437	107	4	one week	DATE
admet-437	108	1	12	CARDINAL
admet-437	109	1	4	CARDINAL
admet-437	110	1	sprague	GPE
admet-437	110	2	dawley	GPE
admet-437	111	1	two	CARDINAL
admet-437	111	2	12	CARDINAL
admet-437	111	3	4	CARDINAL
admet-437	111	4	one week	DATE
admet-437	112	1	1 mg/kg	QUANTITY
admet-437	112	2	2	CARDINAL
admet-437	112	3	10 mg/kg	QUANTITY
admet-437	113	1	100	CARDINAL
admet-437	113	2	500	CARDINAL
admet-437	113	3	0.12	CARDINAL
admet-437	113	4	0.25	CARDINAL
admet-437	113	5	0.5	CARDINAL
admet-437	113	6	1	CARDINAL
admet-437	113	7	2	DATE
admet-437	113	8	4	DATE
admet-437	113	9	8	DATE
admet-437	113	10	24	CARDINAL
admet-437	113	11	0.25	CARDINAL
admet-437	113	12	0.5	CARDINAL
admet-437	113	13	1	CARDINAL
admet-437	113	14	2	DATE
admet-437	113	15	4	DATE
admet-437	113	16	8	DATE
admet-437	113	17	10	DATE
admet-437	114	1	5 min	TIME
admet-437	114	2	14000	CARDINAL
admet-437	114	3	heraeus	GPE
admet-437	114	4	germany	GPE
admet-437	114	5	4 °	QUANTITY
admet-437	115	1	kyoto	GPE
admet-437	115	2	japan	GPE
admet-437	115	3	sil series lc system	GPE
admet-437	115	4	lc-20	GPE
admet-437	115	5	sil-htc	ORG
admet-437	115	6	10	CARDINAL
admet-437	115	7	atlantis	PRODUCT
admet-437	115	8	50	CARDINAL
admet-437	115	9	4.6 mm	QUANTITY
admet-437	115	10	3	CARDINAL
admet-437	115	11	ireland	GPE
admet-437	115	12	uk	GPE
admet-437	115	13	40 °	QUANTITY
admet-437	116	1	0.2 %	PERCENT
admet-437	116	2	10 %	PERCENT
admet-437	116	3	90 %	PERCENT
admet-437	116	4	0.1	CARDINAL
admet-437	116	5	100 %	PERCENT
admet-437	116	6	2.9-4.0 min	QUANTITY
admet-437	116	7	10 %	PERCENT
admet-437	116	8	90 %	PERCENT
admet-437	117	1	0.8 ml/min	QUANTITY
admet-437	117	2	50 %	PERCENT
admet-437	118	1	api-4000	DATE
admet-437	118	2	toronto	GPE
admet-437	118	3	canada	GPE
admet-437	118	4	5(4	CARDINAL
admet-437	118	5	2017	CARDINAL
admet-437	118	6	212	CARDINAL
admet-437	118	7	10.5599	CARDINAL
admet-437	118	8	217	CARDINAL
admet-437	118	9	450 °	QUANTITY
admet-437	118	10	5500	CARDINAL
admet-437	119	1	gs1, gs2	ORG
admet-437	119	2	30	CARDINAL
admet-437	119	3	35	DATE
admet-437	119	4	40	DATE
admet-437	119	5	6	CARDINAL
admet-437	120	1	81	CARDINAL
admet-437	120	2	10	DATE
admet-437	120	3	49	DATE
admet-437	120	4	15	CARDINAL
admet-437	120	5	80	CARDINAL
admet-437	120	6	10	DATE
admet-437	120	7	29	DATE
admet-437	120	8	14	CARDINAL
admet-437	121	1	433	CARDINAL
admet-437	121	2	262	CARDINAL
admet-437	121	3	180	CARDINAL
admet-437	121	4	110	CARDINAL
admet-437	123	1	150 msec	QUANTITY
admet-437	124	1	50	CARDINAL
admet-437	124	2	200	CARDINAL
admet-437	124	3	1:1	CARDINAL
admet-437	124	4	200 ng	QUANTITY
admet-437	124	5	14,000	CARDINAL
admet-437	124	6	5 min	DATE
admet-437	124	7	5424r	DATE
admet-437	124	8	germany	GPE
admet-437	124	9	5 °	QUANTITY
admet-437	125	1	125	CARDINAL
admet-437	125	2	5	CARDINAL
admet-437	125	3	16	CARDINAL
admet-437	126	1	1.05	CARDINAL
admet-437	127	1	3.14	CARDINAL
admet-437	127	2	1048	CARDINAL
admet-437	127	3	1747 ng	QUANTITY
admet-437	129	1	67 %	PERCENT
admet-437	129	2	qc	LOC
admet-437	129	3	85-115 %	PERCENT
admet-437	129	4	less than 50 %	PERCENT
admet-437	129	5	qc	LOC
admet-437	131	1	7.0	CARDINAL
admet-437	133	1	i.v.	PERSON
admet-437	135	1	100	CARDINAL
admet-437	135	2	1	CARDINAL
admet-437	136	1	2	CARDINAL
admet-437	137	1	clint	PERSON
admet-437	138	1	3	CARDINAL
admet-437	139	1	r.	NORP
admet-437	139	2	al. admet &	ORG
admet-437	139	3	5(4	CARDINAL
admet-437	139	4	2017	CARDINAL
admet-437	139	5	212	CARDINAL
admet-437	140	1	1	CARDINAL
admet-437	140	2	1 µm	CARDINAL
admet-437	140	3	clint	PERSON
admet-437	140	4	44.5	CARDINAL
admet-437	140	5	19.3 27.7	CARDINAL
admet-437	140	6	16.4	CARDINAL
admet-437	140	7	5.7 7.6	CARDINAL
admet-437	140	8	35.5	CARDINAL
admet-437	140	9	13.3 9.1	CARDINAL
admet-437	140	10	12.8	CARDINAL
admet-437	140	11	9.8 5.4	CARDINAL
admet-437	140	12	2	CARDINAL
admet-437	140	13	3 µm	CARDINAL
admet-437	140	14	clint	PERSON
admet-437	140	15	(ml/min/kg	QUANTITY
admet-437	140	16	79	CARDINAL
admet-437	140	17	27	CARDINAL
admet-437	140	18	410 1.7 7.1	QUANTITY
admet-437	140	19	76 73	DATE
admet-437	140	20	9.1 16.4	CARDINAL
admet-437	140	21	37	CARDINAL
admet-437	140	22	2.3 5.0	CARDINAL
admet-437	140	23	3	CARDINAL
admet-437	140	24	10 -6 cm/sec	QUANTITY
admet-437	140	25	10	CARDINAL
admet-437	140	26	2.67 3.02	CARDINAL
admet-437	140	27	5.0	CARDINAL
admet-437	140	28	10.5	CARDINAL
admet-437	140	29	0.001	CARDINAL
admet-437	140	30	0.003	CARDINAL
admet-437	140	31	0.050	CARDINAL
admet-437	142	1	ic50	ORG
admet-437	142	2	3a4	CARDINAL
admet-437	142	3	2c9	CARDINAL
admet-437	142	4	2c19	CARDINAL
admet-437	142	5	cyp1a2	ORG
admet-437	142	6	ic50	ORG
admet-437	142	7	20	CARDINAL
admet-437	142	8	3a4	CARDINAL
admet-437	142	9	two	CARDINAL
admet-437	143	1	cyp1a2	ORG
admet-437	143	2	2c9	CARDINAL
admet-437	143	3	2c19	CARDINAL
admet-437	143	4	ic50	ORG
admet-437	143	5	20 µm	CARDINAL
admet-437	144	1	4	CARDINAL
admet-437	145	1	5(4	CARDINAL
admet-437	145	2	2017	CARDINAL
admet-437	145	3	212	CARDINAL
admet-437	145	4	10.5599	CARDINAL
admet-437	145	5	219	CARDINAL
admet-437	145	6	two	CARDINAL
admet-437	145	7	1 and 10	DATE
admet-437	147	1	4	CARDINAL
admet-437	148	1	ic50	ORG
admet-437	148	2	ic50	PRODUCT
admet-437	148	3	cyp2c19	CARDINAL
admet-437	148	4	20 >20	CARDINAL
admet-437	148	5	20	CARDINAL
admet-437	148	6	0.12 nt	MONEY
admet-437	148	7	0.72	CARDINAL
admet-437	149	1	1.02	CARDINAL
admet-437	149	2	0.58	CARDINAL
admet-437	149	3	cyp1a2	ORG
admet-437	149	4	2b6	CARDINAL
admet-437	149	5	2c9	CARDINAL
admet-437	149	6	2c19	CARDINAL
admet-437	149	7	3a4	CARDINAL
admet-437	149	8	cyp1a2	ORG
admet-437	149	9	2c9	CARDINAL
admet-437	149	10	2c19	CARDINAL
admet-437	149	11	3a4	CARDINAL
admet-437	151	1	6	CARDINAL
admet-437	152	1	2a	CARDINAL
admet-437	152	2	2b	CARDINAL
admet-437	153	1	5	CARDINAL
admet-437	154	1	10 mg/kg	QUANTITY
admet-437	156	1	1 mg/kg	QUANTITY
admet-437	159	1	2	CARDINAL
admet-437	159	2	10 mg/kg	QUANTITY
admet-437	159	3	1 mg/kg	QUANTITY
admet-437	159	4	 s.d	PERSON
admet-437	159	5	12	CARDINAL
admet-437	159	6	sprague	GPE
admet-437	159	7	dawley rats	ORG
admet-437	159	8	 s.d	PERSON
admet-437	159	9	4	CARDINAL
admet-437	159	10	2	CARDINAL
admet-437	160	1	al. admet &	ORG
admet-437	160	2	5(4	CARDINAL
admet-437	160	3	2017	CARDINAL
admet-437	160	4	212	CARDINAL
admet-437	160	5	1 mg/kg	QUANTITY
admet-437	161	1	6.24 ml/min/kg	QUANTITY
admet-437	162	1	7 %	PERCENT
admet-437	164	1	0.56 l/kg	QUANTITY
admet-437	164	2	38	CARDINAL
admet-437	164	3	0.015 l/kg	QUANTITY
admet-437	165	1	17	CARDINAL
admet-437	166	1	1.04	CARDINAL
admet-437	166	2	0.5	CARDINAL
admet-437	167	1	2.06	CARDINAL
admet-437	167	2	1.04	CARDINAL
admet-437	168	1	auc0-	GPE
admet-437	168	2	24460	DATE
admet-437	169	1	10 mg/kg	QUANTITY
admet-437	169	2	92 %	PERCENT
admet-437	169	3	5	CARDINAL
admet-437	170	1	5	CARDINAL
admet-437	170	2	1 and 10 mg/kg	QUANTITY
admet-437	170	3	adm	ORG
admet-437	171	1	dose	PERSON
admet-437	173	1	1.0	CARDINAL
admet-437	173	2	6.24 0.56	CARDINAL
admet-437	173	3	10	CARDINAL
admet-437	173	4	0.50	CARDINAL
admet-437	173	5	2.06	CARDINAL
admet-437	173	6	----91.6 sprague dawley rats	ORG
admet-437	173	7	1.0	CARDINAL
admet-437	173	8	± 1812	DATE
admet-437	173	9	2.52 ±	MONEY
admet-437	173	10	1.0 1091	CARDINAL
admet-437	173	11	15.5 1.61	CARDINAL
admet-437	173	12	10 3687	CARDINAL
admet-437	173	13	2.00 1.29	QUANTITY
admet-437	173	14	1 mg/kg	QUANTITY
admet-437	174	1	1.67 ml	QUANTITY
admet-437	174	2	3 %	PERCENT
admet-437	175	1	0.36 l/kg	QUANTITY
admet-437	176	1	2.52	CARDINAL
admet-437	176	2	0.75	CARDINAL
admet-437	177	1	auc0-	GPE
admet-437	177	2	98421 ng*h/ml	QUANTITY
admet-437	178	1	2.02	CARDINAL
admet-437	178	2	half	CARDINAL
admet-437	179	1	10 mg/kg	QUANTITY
admet-437	179	2	98 %	PERCENT
admet-437	179	3	5	CARDINAL
admet-437	180	1	1 mg/kg	QUANTITY
admet-437	181	1	15.5 ml	QUANTITY
admet-437	181	2	~50	ORG
admet-437	183	1	1.61 l/kg	QUANTITY
admet-437	184	1	1.21	CARDINAL
admet-437	184	2	1442 ng/ml	QUANTITY
admet-437	184	3	2.00	CARDINAL
admet-437	185	1	auc0-	GPE
admet-437	185	2	3687	DATE
admet-437	186	1	1.29	CARDINAL
admet-437	186	2	10 mg/kg	QUANTITY
admet-437	186	3	34 %	PERCENT
admet-437	186	4	5	CARDINAL
admet-437	187	1	5(4	CARDINAL
admet-437	187	2	2017	CARDINAL
admet-437	187	3	212	CARDINAL
admet-437	187	4	10.5599	CARDINAL
admet-437	187	5	221	CARDINAL
admet-437	187	6	ras/raf/mek	ORG
admet-437	187	7	2	CARDINAL
admet-437	187	8	mek	ORG
admet-437	187	9	ras/raf/mek	ORG
admet-437	187	10	18	CARDINAL
admet-437	188	1	mek	ORG
admet-437	189	1	3	CARDINAL
admet-437	190	1	mek	ORG
admet-437	192	1	6	CARDINAL
admet-437	194	1	linear	ORG
admet-437	194	2	up to	QUANTITY
admet-437	194	3	600 mg	QUANTITY
admet-437	194	4	mtd	ORG
admet-437	194	5	7	CARDINAL
admet-437	200	1	19	CARDINAL
admet-437	201	1	2.67 x	QUANTITY
admet-437	201	2	10-6 cm	QUANTITY
admet-437	201	3	sec	ORG
admet-437	201	4	8.09	CARDINAL
admet-437	201	5	10 -6 cm	QUANTITY
admet-437	202	1	ic50	ORG
admet-437	202	2	greater than 20	CARDINAL
admet-437	205	1	two	CARDINAL
admet-437	205	2	92 %	PERCENT
admet-437	206	1	34 %	PERCENT
admet-437	206	2	0.001	CARDINAL
admet-437	206	3	0.003	CARDINAL
admet-437	208	1	50	CARDINAL
admet-437	208	2	3.0	CARDINAL
admet-437	208	3	7.0 %	PERCENT
admet-437	208	4	hbf	ORG
admet-437	209	1	devoid of drug-drug interactions liability	ORG
admet-437	211	1	r. mullangi et	PERSON
admet-437	211	2	al. admet &	ORG
admet-437	211	3	5(4	CARDINAL
admet-437	211	4	2017	CARDINAL
admet-437	211	5	212	CARDINAL
admet-437	211	6	222	CARDINAL
admet-437	211	7	1	CARDINAL
admet-437	211	8	a. akinleye	PERSON
admet-437	211	9	m. furqan	PERSON
admet-437	211	10	n. mukhi	PERSON
admet-437	211	11	p. ravella	PERSON
admet-437	211	12	d. liu	PERSON
admet-437	212	1	mek	PERSON
admet-437	212	2	bedside.	ORG
admet-437	213	1	journal of hematology &	ORG
admet-437	213	2	6	CARDINAL
admet-437	213	3	27	DATE
admet-437	214	1	2	CARDINAL
admet-437	214	2	p. crespo	PERSON
admet-437	216	1	2010	DATE
admet-437	216	2	674	CARDINAL
admet-437	217	1	3	CARDINAL
admet-437	217	2	m. warthaka	PERSON
admet-437	217	3	c.h.	PERSON
admet-437	217	4	adelmann	ORG
admet-437	217	5	t.s. kaoud	PERSON
admet-437	217	6	r. edupuganti	PERSON
admet-437	217	7	yan	PERSON
admet-437	217	8	w.h. johnson jr,	PERSON
admet-437	217	9	s. ferguson	PERSON
admet-437	217	10	c.d. tavares	PERSON
admet-437	217	11	l.j. pence	ORG
admet-437	217	12	anslyn	PERSON
admet-437	217	13	p. ren	PERSON
admet-437	217	14	k.y. tsai	PERSON
admet-437	217	15	k.n. dalby	GPE
admet-437	219	1	acs medicinal chemistry	ORG
admet-437	219	2	5	CARDINAL
admet-437	219	3	2015	CARDINAL
admet-437	219	4	47	CARDINAL
admet-437	220	1	4	CARDINAL
admet-437	221	1	ras oncogenes	ORG
admet-437	222	1	49	CARDINAL
admet-437	222	2	1989	DATE
admet-437	222	3	4682-4689	CARDINAL
admet-437	223	1	5	CARDINAL
admet-437	223	2	w.j.	PERSON
admet-437	223	3	ding	PERSON
admet-437	223	4	w.p. tao	PERSON
admet-437	223	5	t. zeng	PERSON
admet-437	223	6	j.j. deng	PERSON
admet-437	223	7	h.b. lei	PERSON
admet-437	223	8	w. ge	PERSON
admet-437	225	1	9	CARDINAL
admet-437	225	2	10955-10962	DATE
admet-437	226	1	6	CARDINAL
admet-437	226	2	b. furey	PERSON
admet-437	226	3	j. roix	PERSON
admet-437	226	4	w. markland	PERSON
admet-437	226	5	r. hoover	GPE
admet-437	226	6	a. aronov	PERSON
admet-437	226	7	m. hale	PERSON
admet-437	226	8	g. chen	PERSON
admet-437	226	9	g. martinezbotella	PERSON
admet-437	226	10	r. alargova	PERSON
admet-437	226	11	b.	PERSON
admet-437	226	12	d. sorrell	PERSON
admet-437	226	13	k. meshaw	PERSON
admet-437	226	14	p. shapiro	PERSON
admet-437	226	15	m. j. wick	PERSON
admet-437	226	16	c. benes	PERSON
admet-437	226	17	m. garnett	PERSON
admet-437	226	18	g. decrescenzo	PERSON
admet-437	226	19	m. namchuk	PERSON
admet-437	226	20	s. saha	PERSON
admet-437	226	21	d.j. welsch	PERSON
admet-437	228	1	75	CARDINAL
admet-437	230	1	7	CARDINAL
admet-437	230	2	f. janku	PERSON
admet-437	230	3	a.w.	GPE
admet-437	230	4	m.r. patel	PERSON
admet-437	230	5	sullivan	PERSON
admet-437	230	6	k. flaherty	PERSON
admet-437	230	7	r.d. carvajal	PERSON
admet-437	230	8	varghese	PERSON
admet-437	230	9	d.j. lee wong	PERSON
admet-437	230	10	m. sznol	PERSON
admet-437	230	11	j.a.	GPE
admet-437	230	12	sosman	ORG
admet-437	230	13	a. wang-gillam	PERSON
admet-437	230	14	h.a. burris	PERSON
admet-437	230	15	a. ribas	PERSON
admet-437	230	16	s.p. patel	PERSON
admet-437	230	17	d.j. welsch	GPE
admet-437	230	18	s. saha	PERSON
admet-437	231	1	first	ORDINAL
admet-437	231	2	1/2	CARDINAL
admet-437	232	1	2015	CARDINAL
admet-437	233	1	8	CARDINAL
admet-437	234	1	twenty-nine	CARDINAL
admet-437	234	2	half	CARDINAL
admet-437	235	1	27 (1999	DATE
admet-437	235	2	1350-1359	CARDINAL
admet-437	236	1	9	CARDINAL
admet-437	236	2	mcginnity	PERSON
admet-437	236	3	m.g.	PERSON
admet-437	236	4	r.a.	ORG
admet-437	236	5	urbanowicz	PERSON
admet-437	236	6	r.j. riley	PERSON
admet-437	238	1	32 (2004	DATE
admet-437	238	2	1247-1253	DATE
admet-437	239	1	10	CARDINAL
admet-437	239	2	z. wang	PERSON
admet-437	239	3	c.e.	GPE
admet-437	239	4	k.h. leung	PERSON
admet-437	239	5	j. pang	PERSON
admet-437	241	1	35	CARDINAL
admet-437	241	2	71	CARDINAL
admet-437	242	1	11	CARDINAL
admet-437	242	2	p.v.	GPE
admet-437	242	3	han	NORP
admet-437	242	4	s. chong	PERSON
admet-437	244	1	aaps 8 (2006	DATE
admet-437	245	1	12	CARDINAL
admet-437	245	2	i. kariv	PERSON
admet-437	245	3	h. cao	PERSON
admet-437	245	4	k.r. oldenburg	GPE
admet-437	247	1	90 (2001	DATE
admet-437	248	1	580	CARDINAL
admet-437	249	1	13	CARDINAL
admet-437	249	2	r.s obach	PERSON
admet-437	249	3	r.l.	PERSON
admet-437	249	4	walsky	PERSON
admet-437	249	5	k. venkatakrishnan	PERSON
admet-437	249	6	e.a. gaman	ORG
admet-437	249	7	j.b.	PERSON
admet-437	249	8	houston	GPE
admet-437	249	9	l.m. tremaine	PERSON
admet-437	251	1	316	DATE
admet-437	251	2	2006	DATE
admet-437	251	3	336	CARDINAL
admet-437	252	1	14	CARDINAL
admet-437	252	2	einolf	PERSON
admet-437	252	3	r. evers	PERSON
admet-437	252	4	g. kumar	PERSON
admet-437	252	5	d. moore	PERSON
admet-437	252	6	s. ripp	PERSON
admet-437	252	7	j. silva	PERSON
admet-437	252	8	v. sinha	PERSON
admet-437	252	9	m. sinz	PERSON
admet-437	252	10	a. skerjanec	PERSON
admet-437	253	1	america	GPE
admet-437	254	1	37	DATE
admet-437	254	2	2009	DATE
admet-437	254	3	1350-1359	CARDINAL
admet-437	255	1	15	CARDINAL
admet-437	255	2	harper	PERSON
admet-437	255	3	p.j. brassil.	ORG
admet-437	257	1	aaps 10 (2008	DATE
admet-437	257	2	200	CARDINAL
admet-437	258	1	5(4	CARDINAL
admet-437	258	2	2017	CARDINAL
admet-437	258	3	212	CARDINAL
admet-437	258	4	10.5599	CARDINAL
admet-437	258	5	223	CARDINAL
admet-437	259	1	16	CARDINAL
admet-437	259	2	r. kumar	PERSON
admet-437	259	3	p.s. suresh	PERSON
admet-437	259	4	g. rudresh	PERSON
admet-437	259	5	m. zainuddin	PERSON
admet-437	259	6	dewang	GPE
admet-437	259	7	r.r. kethiri	PERSON
admet-437	259	8	s. rajagopal	PERSON
admet-437	259	9	r. mullangi	PERSON
admet-437	261	1	125	CARDINAL
admet-437	261	2	2016	CARDINAL
admet-437	261	3	140	CARDINAL
admet-437	262	1	17	CARDINAL
admet-437	262	2	t. morris	ORG
admet-437	263	1	10	CARDINAL
admet-437	263	2	1993	DATE
admet-437	263	3	1093	CARDINAL
admet-437	264	1	18	CARDINAL
admet-437	264	2	flaherty	ORG
admet-437	264	3	j.r. infante	PERSON
admet-437	264	4	a. daud	PERSON
admet-437	264	5	r. gonzalez	PERSON
admet-437	264	6	r.f. kefford	PERSON
admet-437	264	7	j. sosman	PERSON
admet-437	264	8	o. hamid	PERSON
admet-437	264	9	l. schuchter	PERSON
admet-437	264	10	j. cebon	PERSON
admet-437	264	11	n. ibrahim	PERSON
admet-437	264	12	r. kudchadkar	PERSON
admet-437	264	13	h.a.	PERSON
admet-437	264	14	3rd	ORDINAL
admet-437	264	15	g. falchook,	PERSON
admet-437	264	16	a. algazi	PERSON
admet-437	264	17	k. lewis	PERSON
admet-437	264	18	g.v. long	PERSON
admet-437	264	19	i. puzanov	PERSON
admet-437	264	20	p. lebowitz	PERSON
admet-437	264	21	a. singh	PERSON
admet-437	264	22	s. little	ORG
admet-437	264	23	a. allred	PERSON
admet-437	264	24	d. ouellet	PERSON
admet-437	264	25	kim	PERSON
admet-437	264	26	k. patel	PERSON
admet-437	264	27	j. weber	PERSON
admet-437	264	28	mek	ORG
admet-437	264	29	v600	ORG
admet-437	265	1	new england journal	ORG
admet-437	265	2	367	CARDINAL
admet-437	265	3	2012	DATE
admet-437	265	4	1694	CARDINAL
admet-437	266	1	19	CARDINAL
admet-437	266	2	chan	GPE
admet-437	266	3	s. lowes	GPE
admet-437	266	4	b.h.	GPE
admet-437	266	5	hirst	ORG
admet-437	267	1	the abcs of drug transport	ORG
admet-437	268	1	european journal of pharmaceutical sciences	ORG
admet-437	268	2	21 (2004	DATE
admet-437	268	3	25	CARDINAL
admet-437	269	1	2017	CARDINAL
admet-437	269	2	iapc	ORG
admet-437	269	3	zagreb	GPE
admet-437	269	4	croatia	GPE
admet-437	270	1	http://creativecommons.org/licenses/by/3.0/	ORG
admet-437	270	2	http://creativecommons.org/licenses/by/3.0/	ORG