id	sid	tid	token	lemma	pos
admet-1022	1	1	drug	drug	NOUN
admet-1022	1	2	-	-	PUNCT
admet-1022	1	3	like	like	ADJ
admet-1022	1	4	properties	property	NOUN
admet-1022	1	5	and	and	CCONJ
admet-1022	1	6	fraction	fraction	NOUN
admet-1022	1	7	lipophilicity	lipophilicity	NOUN
admet-1022	1	8	index	index	NOUN
admet-1022	1	9	as	as	ADP
admet-1022	1	10	a	a	DET
admet-1022	1	11	combined	combined	ADJ
admet-1022	1	12	metric	metric	ADJ
admet-1022	1	13	doi	doi	NOUN
admet-1022	1	14	:	:	PUNCT
admet-1022	1	15	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	1	16	177	177	NUM
admet-1022	1	17	admet	admet	X
admet-1022	1	18	&	&	CCONJ
admet-1022	1	19	dmpk	dmpk	PROPN
admet-1022	1	20	9(3	9(3	NUM
admet-1022	1	21	)	)	PUNCT
admet-1022	1	22	(	(	PUNCT
admet-1022	1	23	2021	2021	NUM
admet-1022	1	24	)	)	PUNCT
admet-1022	1	25	177	177	NUM
admet-1022	1	26	-	-	SYM
admet-1022	1	27	190	190	NUM
admet-1022	1	28	;	;	PUNCT
admet-1022	1	29	doi	doi	NOUN
admet-1022	1	30	:	:	PUNCT
admet-1022	1	31	https://dx.doi.org/10.5599/admet.1022	https://dx.doi.org/10.5599/admet.1022	NOUN
admet-1022	1	32	open	open	ADJ
admet-1022	1	33	access	access	NOUN
admet-1022	1	34	:	:	PUNCT
admet-1022	1	35	issn	issn	PROPN
admet-1022	1	36	:	:	PUNCT
admet-1022	1	37	1848	1848	NUM
admet-1022	1	38	-	-	SYM
admet-1022	1	39	7718	7718	NUM
admet-1022	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1022	1	41	original	original	ADJ
admet-1022	1	42	scientific	scientific	ADJ
admet-1022	1	43	paper	paper	NOUN
admet-1022	1	44	drug	drug	NOUN
admet-1022	1	45	-	-	PUNCT
admet-1022	1	46	like	like	ADJ
admet-1022	1	47	properties	property	NOUN
admet-1022	1	48	and	and	CCONJ
admet-1022	1	49	fraction	fraction	NOUN
admet-1022	1	50	lipophilicity	lipophilicity	NOUN
admet-1022	1	51	index	index	NOUN
admet-1022	1	52	as	as	ADP
admet-1022	1	53	a	a	DET
admet-1022	1	54	combined	combine	VERB
admet-1022	1	55	metric	metric	ADJ
admet-1022	1	56	anna	anna	NOUN
admet-1022	1	57	tsantili	tsantili	NOUN
admet-1022	1	58	-	-	PUNCT
admet-1022	1	59	kakoulidou1	kakoulidou1	NOUN
admet-1022	1	60	*	*	PUNCT
admet-1022	1	61	and	and	CCONJ
admet-1022	1	62	vassilis	vassilis	PROPN
admet-1022	1	63	j.	j.	PROPN
admet-1022	1	64	demopoulos2	demopoulos2	PROPN
admet-1022	1	65	1	1	NUM
admet-1022	1	66	department	department	NOUN
admet-1022	1	67	of	of	ADP
admet-1022	1	68	pharmaceutical	pharmaceutical	ADJ
admet-1022	1	69	chemistry	chemistry	NOUN
admet-1022	1	70	,	,	PUNCT
admet-1022	1	71	school	school	NOUN
admet-1022	1	72	of	of	ADP
admet-1022	1	73	pharmacy	pharmacy	NOUN
admet-1022	1	74	,	,	PUNCT
admet-1022	1	75	national	national	ADJ
admet-1022	1	76	and	and	CCONJ
admet-1022	1	77	kapodistrian	kapodistrian	ADJ
admet-1022	1	78	university	university	PROPN
admet-1022	1	79	of	of	ADP
admet-1022	1	80	athens	athens	PROPN
admet-1022	1	81	,	,	PUNCT
admet-1022	1	82	panepistimiopolis	panepistimiopolis	PROPN
admet-1022	1	83	,	,	PUNCT
admet-1022	1	84	zografou	zografou	PROPN
admet-1022	1	85	,	,	PUNCT
admet-1022	1	86	157	157	NUM
admet-1022	1	87	71	71	NUM
admet-1022	1	88	athens	athen	NOUN
admet-1022	1	89	,	,	PUNCT
admet-1022	1	90	greece	greece	PROPN
admet-1022	1	91	.	.	PUNCT
admet-1022	2	1	e	e	X
admet-1022	2	2	-	-	NOUN
admet-1022	2	3	mail	mail	NOUN
admet-1022	2	4	:	:	PUNCT
admet-1022	2	5	tsantili@pharm.uoa.gr	tsantili@pharm.uoa.gr	NOUN
admet-1022	2	6	2	2	NUM
admet-1022	2	7	department	department	NOUN
admet-1022	2	8	of	of	ADP
admet-1022	2	9	pharmaceutical	pharmaceutical	ADJ
admet-1022	2	10	chemistry	chemistry	NOUN
admet-1022	2	11	,	,	PUNCT
admet-1022	2	12	school	school	NOUN
admet-1022	2	13	of	of	ADP
admet-1022	2	14	pharmacy	pharmacy	NOUN
admet-1022	2	15	,	,	PUNCT
admet-1022	2	16	aristotle	aristotle	PROPN
admet-1022	2	17	university	university	PROPN
admet-1022	2	18	of	of	ADP
admet-1022	2	19	thessaloniki	thessaloniki	PROPN
admet-1022	2	20	,	,	PUNCT
admet-1022	2	21	54124	54124	NUM
admet-1022	2	22	thessaloniki	thessaloniki	PROPN
admet-1022	2	23	,	,	PUNCT
admet-1022	2	24	greece	greece	PROPN
admet-1022	2	25	.	.	PUNCT
admet-1022	3	1	e	e	X
admet-1022	3	2	-	-	NOUN
admet-1022	3	3	mail	mail	NOUN
admet-1022	3	4	:	:	PUNCT
admet-1022	3	5	vdem@pharm.auth.gr	vdem@pharm.auth.gr	NOUN
admet-1022	3	6	*	*	PUNCT
admet-1022	3	7	corresponding	correspond	VERB
admet-1022	3	8	author	author	NOUN
admet-1022	3	9	received	receive	VERB
admet-1022	3	10	:	:	PUNCT
admet-1022	3	11	june	june	PROPN
admet-1022	3	12	13	13	NUM
admet-1022	3	13	,	,	PUNCT
admet-1022	3	14	2021	2021	NUM
admet-1022	3	15	;	;	PUNCT
admet-1022	3	16	revised	revise	VERB
admet-1022	3	17	:	:	PUNCT
admet-1022	3	18	september	september	PROPN
admet-1022	3	19	30	30	NUM
admet-1022	3	20	,	,	PUNCT
admet-1022	3	21	2021	2021	NUM
admet-1022	3	22	;	;	PUNCT
admet-1022	3	23	published	publish	VERB
admet-1022	3	24	online	online	ADV
admet-1022	3	25	:	:	PUNCT
admet-1022	3	26	october	october	PROPN
admet-1022	3	27	10	10	NUM
admet-1022	3	28	,	,	PUNCT
admet-1022	3	29	2021	2021	NUM
admet-1022	3	30	abstract	abstract	ADJ
admet-1022	3	31	fraction	fraction	NOUN
admet-1022	3	32	lipophicity	lipophicity	NOUN
admet-1022	3	33	index	index	NOUN
admet-1022	3	34	(	(	PUNCT
admet-1022	3	35	fli	fli	NOUN
admet-1022	3	36	)	)	PUNCT
admet-1022	3	37	has	have	AUX
admet-1022	3	38	been	be	AUX
admet-1022	3	39	developed	develop	VERB
admet-1022	3	40	as	as	ADP
admet-1022	3	41	a	a	DET
admet-1022	3	42	composite	composite	ADJ
admet-1022	3	43	drug	drug	NOUN
admet-1022	3	44	-	-	PUNCT
admet-1022	3	45	like	like	ADJ
admet-1022	3	46	metric	metric	ADJ
admet-1022	3	47	combining	combine	VERB
admet-1022	3	48	log	log	NOUN
admet-1022	3	49	p	p	NOUN
admet-1022	3	50	and	and	CCONJ
admet-1022	3	51	log	log	VERB
admet-1022	3	52	d	d	NOUN
admet-1022	3	53	in	in	ADP
admet-1022	3	54	a	a	DET
admet-1022	3	55	weighted	weighted	ADJ
admet-1022	3	56	manner	manner	NOUN
admet-1022	3	57	.	.	PUNCT
admet-1022	4	1	in	in	ADP
admet-1022	4	2	the	the	DET
admet-1022	4	3	present	present	ADJ
admet-1022	4	4	study	study	NOUN
admet-1022	4	5	,	,	PUNCT
admet-1022	4	6	an	an	DET
admet-1022	4	7	extended	extended	ADJ
admet-1022	4	8	data	data	NOUN
admet-1022	4	9	set	set	VERB
admet-1022	4	10	confirmed	confirm	VERB
admet-1022	4	11	the	the	DET
admet-1022	4	12	previously	previously	ADV
admet-1022	4	13	established	establish	VERB
admet-1022	4	14	drug	drug	NOUN
admet-1022	4	15	-	-	PUNCT
admet-1022	4	16	like	like	ADJ
admet-1022	4	17	fli	fli	NOUN
admet-1022	4	18	range	range	NOUN
admet-1022	4	19	0	0	NUM
admet-1022	4	20	-	-	SYM
admet-1022	4	21	8	8	NUM
admet-1022	4	22	using	use	VERB
admet-1022	4	23	two	two	NUM
admet-1022	4	24	calculation	calculation	NOUN
admet-1022	4	25	systems	system	NOUN
admet-1022	4	26	for	for	ADP
admet-1022	4	27	log	log	NOUN
admet-1022	4	28	p	p	X
admet-1022	4	29	/	/	SYM
admet-1022	4	30	log	log	NOUN
admet-1022	4	31	d	d	NOUN
admet-1022	4	32	assessment	assessment	NOUN
admet-1022	4	33	,	,	PUNCT
admet-1022	4	34	the	the	DET
admet-1022	4	35	freeware	freeware	NOUN
admet-1022	4	36	medchem	medchem	NOUN
admet-1022	4	37	designer	designer	NOUN
admet-1022	4	38	and	and	CCONJ
admet-1022	4	39	clogp	clogp	NOUN
admet-1022	4	40	.	.	PUNCT
admet-1022	5	1	the	the	DET
admet-1022	5	2	dataset	dataset	NOUN
admet-1022	5	3	was	be	AUX
admet-1022	5	4	split	split	VERB
admet-1022	5	5	into	into	ADP
admet-1022	5	6	two	two	NUM
admet-1022	5	7	classes	class	NOUN
admet-1022	5	8	according	accord	VERB
admet-1022	5	9	to	to	ADP
admet-1022	5	10	the	the	DET
admet-1022	5	11	percentage	percentage	NOUN
admet-1022	5	12	of	of	ADP
admet-1022	5	13	fraction	fraction	NOUN
admet-1022	5	14	absorbed	absorb	VERB
admet-1022	5	15	(	(	PUNCT
admet-1022	5	16	%	%	INTJ
admet-1022	5	17	fa	fa	NOUN
admet-1022	5	18	)	)	PUNCT
admet-1022	5	19	class	class	NOUN
admet-1022	5	20	1	1	NUM
admet-1022	5	21	including	include	VERB
admet-1022	5	22	drugs	drug	NOUN
admet-1022	5	23	with	with	ADP
admet-1022	5	24	high	high	ADJ
admet-1022	5	25	to	to	PART
admet-1022	5	26	medium	medium	ADJ
admet-1022	5	27	absorption	absorption	NOUN
admet-1022	5	28	levels	level	NOUN
admet-1022	5	29	and	and	CCONJ
admet-1022	5	30	class	class	NOUN
admet-1022	5	31	2	2	NUM
admet-1022	5	32	including	include	VERB
admet-1022	5	33	poorly	poorly	ADV
admet-1022	5	34	absorbed	absorb	VERB
admet-1022	5	35	drugs	drug	NOUN
admet-1022	5	36	.	.	PUNCT
admet-1022	6	1	the	the	DET
admet-1022	6	2	fli	fli	NOUN
admet-1022	6	3	and	and	CCONJ
admet-1022	6	4	fli	fli	NOUN
admet-1022	6	5	-	-	PUNCT
admet-1022	6	6	c	c	NOUN
admet-1022	6	7	(	(	PUNCT
admet-1022	6	8	clogp	clogp	ADJ
admet-1022	6	9	based	base	VERB
admet-1022	6	10	fli	fli	NOUN
admet-1022	6	11	)	)	PUNCT
admet-1022	6	12	drug	drug	NOUN
admet-1022	6	13	-	-	PUNCT
admet-1022	6	14	like	like	ADJ
admet-1022	6	15	range	range	NOUN
admet-1022	6	16	covers	cover	VERB
admet-1022	6	17	92	92	NUM
admet-1022	6	18	%	%	NOUN
admet-1022	6	19	and	and	CCONJ
admet-1022	6	20	91	91	NUM
admet-1022	6	21	%	%	NOUN
admet-1022	6	22	of	of	ADP
admet-1022	6	23	class	class	NOUN
admet-1022	6	24	1	1	NUM
admet-1022	6	25	drugs	drug	NOUN
admet-1022	6	26	,	,	PUNCT
admet-1022	6	27	respectively	respectively	ADV
admet-1022	6	28	.	.	PUNCT
admet-1022	7	1	using	use	VERB
admet-1022	7	2	mlogp	mlogp	NOUN
admet-1022	7	3	,	,	PUNCT
admet-1022	7	4	a	a	DET
admet-1022	7	5	narrower	narrow	ADJ
admet-1022	7	6	drug	drug	NOUN
admet-1022	7	7	-	-	PUNCT
admet-1022	7	8	like	like	ADJ
admet-1022	7	9	fli	fli	ADJ
admet-1022	7	10	-	-	PUNCT
admet-1022	7	11	m	m	PROPN
admet-1022	7	12	range	range	NOUN
admet-1022	7	13	0	0	NUM
admet-1022	7	14	-	-	SYM
admet-1022	7	15	7	7	NUM
admet-1022	7	16	was	be	AUX
admet-1022	7	17	established	establish	VERB
admet-1022	7	18	,	,	PUNCT
admet-1022	7	19	covering	cover	VERB
admet-1022	7	20	91	91	NUM
admet-1022	7	21	%	%	NOUN
admet-1022	7	22	of	of	ADP
admet-1022	7	23	class	class	NOUN
admet-1022	7	24	1	1	NUM
admet-1022	7	25	drugs	drug	NOUN
admet-1022	7	26	.	.	PUNCT
admet-1022	8	1	the	the	DET
admet-1022	8	2	dependence	dependence	NOUN
admet-1022	8	3	of	of	ADP
admet-1022	8	4	the	the	DET
admet-1022	8	5	degree	degree	NOUN
admet-1022	8	6	of	of	ADP
admet-1022	8	7	ionization	ionization	NOUN
admet-1022	8	8	to	to	ADP
admet-1022	8	9	intrinsic	intrinsic	ADJ
admet-1022	8	10	lipophilicity	lipophilicity	NOUN
admet-1022	8	11	within	within	ADP
admet-1022	8	12	the	the	DET
admet-1022	8	13	fli	fli	NOUN
admet-1022	8	14	(	(	PUNCT
admet-1022	8	15	fli	fli	NOUN
admet-1022	8	16	-	-	PUNCT
admet-1022	8	17	c	c	NOUN
admet-1022	8	18	,	,	PUNCT
admet-1022	8	19	fli	fli	NOUN
admet-1022	8	20	-	-	PUNCT
admet-1022	8	21	m	m	NOUN
admet-1022	8	22	)	)	PUNCT
admet-1022	8	23	drug	drug	NOUN
admet-1022	8	24	-	-	PUNCT
admet-1022	8	25	like	like	ADJ
admet-1022	8	26	range	range	NOUN
admet-1022	8	27	as	as	ADV
admet-1022	8	28	well	well	ADV
admet-1022	8	29	as	as	ADP
admet-1022	8	30	the	the	DET
admet-1022	8	31	inter	inter	NOUN
admet-1022	8	32	-	-	NOUN
admet-1022	8	33	relation	relation	NOUN
admet-1022	8	34	between	between	ADP
admet-1022	8	35	the	the	DET
admet-1022	8	36	other	other	ADJ
admet-1022	8	37	ro5	ro5	ADJ
admet-1022	8	38	properties	property	NOUN
admet-1022	8	39	(	(	PUNCT
admet-1022	8	40	mw	mw	PROPN
admet-1022	8	41	,	,	PUNCT
admet-1022	8	42	hd	hd	NOUN
admet-1022	8	43	,	,	PUNCT
admet-1022	8	44	ha	ha	INTJ
admet-1022	8	45	)	)	PUNCT
admet-1022	8	46	was	be	AUX
admet-1022	8	47	explored	explore	VERB
admet-1022	8	48	to	to	PART
admet-1022	8	49	define	define	VERB
admet-1022	8	50	drug	drug	NOUN
admet-1022	8	51	-	-	PUNCT
admet-1022	8	52	like	like	ADJ
admet-1022	8	53	/	/	SYM
admet-1022	8	54	non	non	ADJ
admet-1022	8	55	-	-	ADJ
admet-1022	8	56	drug	drug	ADJ
admet-1022	8	57	-	-	PUNCT
admet-1022	8	58	like	like	ADJ
admet-1022	8	59	combinations	combination	NOUN
admet-1022	8	60	as	as	ADP
admet-1022	8	61	a	a	DET
admet-1022	8	62	safer	safe	ADJ
admet-1022	8	63	alternative	alternative	NOUN
admet-1022	8	64	to	to	ADP
admet-1022	8	65	single	single	ADJ
admet-1022	8	66	properties	property	NOUN
admet-1022	8	67	for	for	ADP
admet-1022	8	68	drug	drug	NOUN
admet-1022	8	69	candidates	candidate	NOUN
admet-1022	8	70	’	'	PUNCT
admet-1022	8	71	prioritization	prioritization	NOUN
admet-1022	8	72	.	.	PUNCT
admet-1022	9	1	in	in	ADP
admet-1022	9	2	this	this	DET
admet-1022	9	3	sense	sense	NOUN
admet-1022	9	4	,	,	PUNCT
admet-1022	9	5	we	we	PRON
admet-1022	9	6	propose	propose	VERB
admet-1022	9	7	a	a	DET
admet-1022	9	8	combined	combine	VERB
admet-1022	9	9	metric	metric	NOUN
admet-1022	9	10	of	of	ADP
admet-1022	9	11	mw	mw	NOUN
admet-1022	9	12	and	and	CCONJ
admet-1022	9	13	the	the	DET
admet-1022	9	14	number	number	NOUN
admet-1022	9	15	of	of	ADP
admet-1022	9	16	polar	polar	ADJ
admet-1022	9	17	atoms	atom	NOUN
admet-1022	9	18	(	(	PUNCT
admet-1022	9	19	mw	mw	PROPN
admet-1022	9	20	/	/	SYM
admet-1022	9	21	no	no	NOUN
admet-1022	9	22	)	)	PUNCT
admet-1022	9	23	to	to	PART
admet-1022	9	24	account	account	VERB
admet-1022	9	25	for	for	ADP
admet-1022	9	26	both	both	DET
admet-1022	9	27	size	size	NOUN
admet-1022	9	28	and	and	CCONJ
admet-1022	9	29	polarity	polarity	NOUN
admet-1022	9	30	.	.	PUNCT
admet-1022	10	1	setting	set	VERB
admet-1022	10	2	the	the	DET
admet-1022	10	3	value	value	NOUN
admet-1022	10	4	50	50	NUM
admet-1022	10	5	as	as	ADP
admet-1022	10	6	cutoff	cutoff	NOUN
admet-1022	10	7	,	,	PUNCT
admet-1022	10	8	a	a	DET
admet-1022	10	9	distinct	distinct	ADJ
admet-1022	10	10	differentiation	differentiation	NOUN
admet-1022	10	11	between	between	ADP
admet-1022	10	12	class	class	NOUN
admet-1022	10	13	1	1	NUM
admet-1022	10	14	and	and	CCONJ
admet-1022	10	15	class	class	NOUN
admet-1022	10	16	2	2	NUM
admet-1022	10	17	drugs	drug	NOUN
admet-1022	10	18	was	be	AUX
admet-1022	10	19	obtained	obtain	VERB
admet-1022	10	20	with	with	ADP
admet-1022	10	21	mw	mw	NOUN
admet-1022	10	22	/	/	SYM
admet-1022	10	23	no>50	no>50	NOUN
admet-1022	10	24	for	for	ADP
admet-1022	10	25	more	more	ADJ
admet-1022	10	26	than	than	ADP
admet-1022	10	27	70	70	NUM
admet-1022	10	28	%	%	NOUN
admet-1022	10	29	of	of	ADP
admet-1022	10	30	class	class	NOUN
admet-1022	10	31	1	1	NUM
admet-1022	10	32	drugs	drug	NOUN
admet-1022	10	33	,	,	PUNCT
admet-1022	10	34	while	while	SCONJ
admet-1022	10	35	the	the	DET
admet-1022	10	36	opposite	opposite	NOUN
admet-1022	10	37	was	be	AUX
admet-1022	10	38	observed	observe	VERB
admet-1022	10	39	for	for	ADP
admet-1022	10	40	class	class	NOUN
admet-1022	10	41	2	2	NUM
admet-1022	10	42	drugs	drug	NOUN
admet-1022	10	43	.	.	PUNCT
admet-1022	11	1	©	©	NOUN
admet-1022	11	2	2021	2021	NUM
admet-1022	11	3	by	by	ADP
admet-1022	11	4	the	the	DET
admet-1022	11	5	authors	author	NOUN
admet-1022	11	6	.	.	PUNCT
admet-1022	12	1	this	this	DET
admet-1022	12	2	article	article	NOUN
admet-1022	12	3	is	be	AUX
admet-1022	12	4	an	an	DET
admet-1022	12	5	open	open	ADJ
admet-1022	12	6	-	-	PUNCT
admet-1022	12	7	access	access	NOUN
admet-1022	12	8	article	article	NOUN
admet-1022	12	9	distributed	distribute	VERB
admet-1022	12	10	under	under	ADP
admet-1022	12	11	the	the	DET
admet-1022	12	12	terms	term	NOUN
admet-1022	12	13	and	and	CCONJ
admet-1022	12	14	conditions	condition	NOUN
admet-1022	12	15	of	of	ADP
admet-1022	12	16	the	the	DET
admet-1022	12	17	creative	creative	ADJ
admet-1022	12	18	commons	common	NOUN
admet-1022	12	19	attribution	attribution	NOUN
admet-1022	12	20	license	license	NOUN
admet-1022	12	21	(	(	PUNCT
admet-1022	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1022	12	23	)	)	PUNCT
admet-1022	12	24	.	.	PUNCT
admet-1022	13	1	keywords	keyword	VERB
admet-1022	13	2	drug	drug	NOUN
admet-1022	13	3	-	-	PUNCT
admet-1022	13	4	likeness	likeness	NOUN
admet-1022	13	5	;	;	PUNCT
admet-1022	13	6	oral	oral	ADJ
admet-1022	13	7	drugs	drug	NOUN
admet-1022	13	8	;	;	PUNCT
admet-1022	13	9	fraction	fraction	NOUN
admet-1022	13	10	lipophilicity	lipophilicity	PROPN
admet-1022	13	11	index	index	NOUN
admet-1022	13	12	;	;	PUNCT
admet-1022	13	13	rule	rule	NOUN
admet-1022	13	14	of	of	ADP
admet-1022	13	15	5	5	NUM
admet-1022	13	16	;	;	PUNCT
admet-1022	13	17	molecular	molecular	ADJ
admet-1022	13	18	weight	weight	NOUN
admet-1022	13	19	;	;	PUNCT
admet-1022	13	20	polar	polar	ADJ
admet-1022	13	21	atoms	atom	NOUN
admet-1022	13	22	introduction	introduction	NOUN
admet-1022	13	23	the	the	DET
admet-1022	13	24	role	role	NOUN
admet-1022	13	25	of	of	ADP
admet-1022	13	26	physicochemical	physicochemical	ADJ
admet-1022	13	27	properties	property	NOUN
admet-1022	13	28	in	in	ADP
admet-1022	13	29	controlling	control	VERB
admet-1022	13	30	the	the	DET
admet-1022	13	31	fate	fate	NOUN
admet-1022	13	32	of	of	ADP
admet-1022	13	33	drug	drug	NOUN
admet-1022	13	34	molecules	molecule	NOUN
admet-1022	13	35	within	within	ADP
admet-1022	13	36	the	the	DET
admet-1022	13	37	organism	organism	NOUN
admet-1022	13	38	and	and	CCONJ
admet-1022	13	39	their	their	PRON
admet-1022	13	40	binding	binding	NOUN
admet-1022	13	41	to	to	ADP
admet-1022	13	42	macromolecules	macromolecule	NOUN
admet-1022	13	43	has	have	AUX
admet-1022	13	44	been	be	AUX
admet-1022	13	45	well	well	ADV
admet-1022	13	46	documented	document	VERB
admet-1022	13	47	.	.	PUNCT
admet-1022	14	1	emphasis	emphasis	NOUN
admet-1022	14	2	has	have	AUX
admet-1022	14	3	been	be	AUX
admet-1022	14	4	given	give	VERB
admet-1022	14	5	to	to	ADP
admet-1022	14	6	lipophilicity	lipophilicity	NOUN
admet-1022	14	7	,	,	PUNCT
admet-1022	14	8	molecular	molecular	ADJ
admet-1022	14	9	size	size	NOUN
admet-1022	14	10	and	and	CCONJ
admet-1022	14	11	polarity	polarity	NOUN
admet-1022	14	12	as	as	ADP
admet-1022	14	13	the	the	DET
admet-1022	14	14	most	most	ADV
admet-1022	14	15	crucial	crucial	ADJ
admet-1022	14	16	properties	property	NOUN
admet-1022	14	17	,	,	PUNCT
admet-1022	14	18	which	which	PRON
admet-1022	14	19	have	have	AUX
admet-1022	14	20	been	be	AUX
admet-1022	14	21	incorporated	incorporate	VERB
admet-1022	14	22	in	in	ADP
admet-1022	14	23	the	the	DET
admet-1022	14	24	majority	majority	NOUN
admet-1022	14	25	of	of	ADP
admet-1022	14	26	the	the	DET
admet-1022	14	27	metrics	metric	NOUN
admet-1022	14	28	used	use	VERB
admet-1022	14	29	to	to	PART
admet-1022	14	30	set	set	VERB
admet-1022	14	31	boundaries	boundary	NOUN
admet-1022	14	32	in	in	ADP
admet-1022	14	33	the	the	DET
admet-1022	14	34	drug	drug	NOUN
admet-1022	14	35	-	-	PUNCT
admet-1022	14	36	like	like	ADJ
admet-1022	14	37	chemical	chemical	NOUN
admet-1022	14	38	space	space	NOUN
admet-1022	14	39	[	[	X
admet-1022	14	40	1,2	1,2	NUM
admet-1022	14	41	]	]	PUNCT
admet-1022	14	42	.	.	PUNCT
admet-1022	15	1	there	there	PRON
admet-1022	15	2	is	be	VERB
admet-1022	15	3	strong	strong	ADJ
admet-1022	15	4	evidence	evidence	NOUN
admet-1022	15	5	that	that	SCONJ
admet-1022	15	6	compounds	compound	VERB
admet-1022	15	7	with	with	ADP
admet-1022	15	8	higher	high	ADJ
admet-1022	15	9	lipophilicity	lipophilicity	NOUN
admet-1022	15	10	and	and	CCONJ
admet-1022	15	11	higher	high	ADJ
admet-1022	15	12	molecular	molecular	ADJ
admet-1022	15	13	weight	weight	NOUN
admet-1022	15	14	,	,	PUNCT
admet-1022	15	15	e.g.	e.g.	ADV
admet-1022	15	16	,	,	PUNCT
admet-1022	15	17	with	with	ADP
admet-1022	15	18	high	high	ADJ
admet-1022	15	19	molecular	molecular	ADJ
admet-1022	15	20	‘	'	PUNCT
admet-1022	15	21	obesity	obesity	NOUN
admet-1022	15	22	’	'	PUNCT
admet-1022	15	23	are	be	AUX
admet-1022	15	24	more	more	ADV
admet-1022	15	25	likely	likely	ADJ
admet-1022	15	26	to	to	PART
admet-1022	15	27	be	be	AUX
admet-1022	15	28	discontinued	discontinue	VERB
admet-1022	15	29	during	during	ADP
admet-1022	15	30	clinical	clinical	ADJ
admet-1022	15	31	development	development	NOUN
admet-1022	15	32	[	[	X
admet-1022	15	33	3	3	NUM
admet-1022	15	34	-	-	SYM
admet-1022	15	35	6	6	NUM
admet-1022	15	36	]	]	PUNCT
admet-1022	15	37	.	.	PUNCT
admet-1022	16	1	they	they	PRON
admet-1022	16	2	are	be	AUX
admet-1022	16	3	associated	associate	VERB
admet-1022	16	4	with	with	ADP
admet-1022	16	5	difficulties	difficulty	NOUN
admet-1022	16	6	in	in	ADP
admet-1022	16	7	oral	oral	ADJ
admet-1022	16	8	absorption	absorption	NOUN
admet-1022	16	9	,	,	PUNCT
admet-1022	16	10	while	while	SCONJ
admet-1022	16	11	they	they	PRON
admet-1022	16	12	are	be	AUX
admet-1022	16	13	considered	consider	VERB
admet-1022	16	14	to	to	PART
admet-1022	16	15	exhibit	exhibit	VERB
admet-1022	16	16	increased	increase	VERB
admet-1022	16	17	‘	'	PUNCT
admet-1022	16	18	promiscuity	promiscuity	NOUN
admet-1022	16	19	’	'	PUNCT
admet-1022	16	20	towards	towards	ADP
admet-1022	16	21	biomacromolecules	biomacromolecule	NOUN
admet-1022	16	22	.	.	PUNCT
admet-1022	17	1	as	as	ADP
admet-1022	17	2	a	a	DET
admet-1022	17	3	result	result	NOUN
admet-1022	17	4	,	,	PUNCT
admet-1022	17	5	they	they	PRON
admet-1022	17	6	may	may	AUX
admet-1022	17	7	lack	lack	VERB
admet-1022	17	8	selectivity	selectivity	NOUN
admet-1022	17	9	,	,	PUNCT
admet-1022	17	10	leading	lead	VERB
admet-1022	17	11	to	to	ADP
admet-1022	17	12	side	side	NOUN
admet-1022	17	13	effects	effect	NOUN
admet-1022	17	14	while	while	SCONJ
admet-1022	17	15	they	they	PRON
admet-1022	17	16	accumulate	accumulate	VERB
admet-1022	17	17	in	in	ADP
admet-1022	17	18	the	the	DET
admet-1022	17	19	organism	organism	NOUN
admet-1022	17	20	,	,	PUNCT
admet-1022	17	21	increasing	increase	VERB
admet-1022	17	22	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	17	23	https://dx.doi.org/10.5599/admet.1022	https://dx.doi.org/10.5599/admet.1022	NOUN
admet-1022	17	24	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1022	17	25	mailto:tsantili@pharm.uoa.gr	mailto:tsantili@pharm.uoa.gr	ADV
admet-1022	17	26	mailto:vdem@pharm.auth.gr	mailto:vdem@pharm.auth.gr	ADP
admet-1022	17	27	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1022	17	28	tsantili	tsantili	NOUN
admet-1022	17	29	-	-	PUNCT
admet-1022	17	30	kakoulidou	kakoulidou	NOUN
admet-1022	17	31	and	and	CCONJ
admet-1022	17	32	demopoulos	demopoulos	PROPN
admet-1022	17	33	admet	admet	PROPN
admet-1022	17	34	&	&	CCONJ
admet-1022	17	35	dmpk	dmpk	PROPN
admet-1022	17	36	9(3	9(3	NUM
admet-1022	17	37	)	)	PUNCT
admet-1022	17	38	(	(	PUNCT
admet-1022	17	39	2021	2021	NUM
admet-1022	17	40	)	)	PUNCT
admet-1022	17	41	177	177	NUM
admet-1022	17	42	-	-	SYM
admet-1022	17	43	190	190	NUM
admet-1022	17	44	178	178	NUM
admet-1022	17	45	non	non	ADJ
admet-1022	17	46	-	-	ADJ
admet-1022	17	47	selective	selective	ADJ
admet-1022	17	48	toxicity	toxicity	NOUN
admet-1022	17	49	.	.	PUNCT
admet-1022	18	1	the	the	DET
admet-1022	18	2	minimal	minimal	ADJ
admet-1022	18	3	hydrophobicity	hydrophobicity	NOUN
admet-1022	18	4	concept	concept	NOUN
admet-1022	18	5	was	be	AUX
admet-1022	18	6	formulated	formulate	VERB
admet-1022	18	7	in	in	ADP
admet-1022	18	8	1987	1987	NUM
admet-1022	18	9	by	by	ADP
admet-1022	18	10	hansch	hansch	PROPN
admet-1022	18	11	et	et	PROPN
admet-1022	18	12	al	al	PROPN
admet-1022	18	13	.	.	PUNCT
admet-1022	19	1	[	[	X
admet-1022	19	2	7	7	NUM
admet-1022	19	3	]	]	PUNCT
admet-1022	19	4	,	,	PUNCT
admet-1022	19	5	who	who	PRON
admet-1022	19	6	suggested	suggest	VERB
admet-1022	19	7	that	that	SCONJ
admet-1022	19	8	molecules	molecule	NOUN
admet-1022	19	9	exert	exert	VERB
admet-1022	19	10	their	their	PRON
admet-1022	19	11	action	action	NOUN
admet-1022	19	12	rather	rather	ADV
admet-1022	19	13	by	by	ADP
admet-1022	19	14	specific	specific	ADJ
admet-1022	19	15	binding	binding	NOUN
admet-1022	19	16	and	and	CCONJ
admet-1022	19	17	not	not	PART
admet-1022	19	18	by	by	ADP
admet-1022	19	19	non	non	ADJ
admet-1022	19	20	-	-	ADJ
admet-1022	19	21	specific	specific	ADJ
admet-1022	19	22	hydrophobic	hydrophobic	NOUN
admet-1022	19	23	interactions	interaction	NOUN
admet-1022	19	24	.	.	PUNCT
admet-1022	20	1	ten	ten	NUM
admet-1022	20	2	years	year	NOUN
admet-1022	20	3	later	later	ADV
admet-1022	20	4	,	,	PUNCT
admet-1022	20	5	the	the	DET
admet-1022	20	6	well	well	ADV
admet-1022	20	7	-	-	PUNCT
admet-1022	20	8	known	know	VERB
admet-1022	20	9	rule	rule	NOUN
admet-1022	20	10	of	of	ADP
admet-1022	20	11	five	five	NUM
admet-1022	20	12	(	(	PUNCT
admet-1022	20	13	ro5	ro5	NOUN
admet-1022	20	14	)	)	PUNCT
admet-1022	20	15	formulated	formulate	VERB
admet-1022	20	16	by	by	ADP
admet-1022	20	17	lipinski	lipinski	PROPN
admet-1022	20	18	for	for	ADP
admet-1022	20	19	compounds	compound	NOUN
admet-1022	20	20	intended	intend	VERB
admet-1022	20	21	for	for	ADP
admet-1022	20	22	oral	oral	ADJ
admet-1022	20	23	administration	administration	NOUN
admet-1022	20	24	[	[	X
admet-1022	20	25	8	8	NUM
admet-1022	20	26	]	]	PUNCT
admet-1022	20	27	suggested	suggest	VERB
admet-1022	20	28	upper	upper	ADJ
admet-1022	20	29	limits	limit	NOUN
admet-1022	20	30	for	for	ADP
admet-1022	20	31	lipophilicity	lipophilicity	NOUN
admet-1022	20	32	(	(	PUNCT
admet-1022	20	33	clogp≤5	clogp≤5	PROPN
admet-1022	20	34	)	)	PUNCT
admet-1022	20	35	,	,	PUNCT
admet-1022	20	36	molecular	molecular	ADJ
admet-1022	20	37	weight	weight	NOUN
admet-1022	20	38	(	(	PUNCT
admet-1022	20	39	mw≤500	mw≤500	PROPN
admet-1022	20	40	)	)	PUNCT
admet-1022	20	41	,	,	PUNCT
admet-1022	20	42	counts	count	NOUN
admet-1022	20	43	of	of	ADP
admet-1022	20	44	hydrogen	hydrogen	NOUN
admet-1022	20	45	bond	bond	NOUN
admet-1022	20	46	donor	donor	NOUN
admet-1022	20	47	(	(	PUNCT
admet-1022	20	48	hd≤5	hd≤5	PROPN
admet-1022	20	49	)	)	PUNCT
admet-1022	20	50	and	and	CCONJ
admet-1022	20	51	acceptor	acceptor	NOUN
admet-1022	20	52	sites	site	NOUN
admet-1022	20	53	(	(	PUNCT
admet-1022	20	54	ha≤10	ha≤10	PROPN
admet-1022	20	55	)	)	PUNCT
admet-1022	20	56	,	,	PUNCT
admet-1022	20	57	the	the	DET
admet-1022	20	58	latter	latter	ADJ
admet-1022	20	59	two	two	NUM
admet-1022	20	60	expressing	express	VERB
admet-1022	20	61	polarity	polarity	NOUN
admet-1022	20	62	.	.	PUNCT
admet-1022	21	1	compounds	compound	NOUN
admet-1022	21	2	violating	violate	VERB
admet-1022	21	3	more	more	ADJ
admet-1022	21	4	than	than	ADP
admet-1022	21	5	two	two	NUM
admet-1022	21	6	of	of	ADP
admet-1022	21	7	the	the	DET
admet-1022	21	8	ro5	ro5	ADJ
admet-1022	21	9	conditions	condition	NOUN
admet-1022	21	10	are	be	AUX
admet-1022	21	11	prone	prone	ADJ
admet-1022	21	12	to	to	ADP
admet-1022	21	13	gastrointestinal	gastrointestinal	ADJ
admet-1022	21	14	absorption	absorption	NOUN
admet-1022	21	15	problems	problem	NOUN
admet-1022	21	16	.	.	PUNCT
admet-1022	22	1	ro5	ro5	ADJ
admet-1022	22	2	as	as	ADV
admet-1022	22	3	well	well	ADV
admet-1022	22	4	as	as	ADP
admet-1022	22	5	limits	limit	NOUN
admet-1022	22	6	or	or	CCONJ
admet-1022	22	7	ranges	range	NOUN
admet-1022	22	8	for	for	ADP
admet-1022	22	9	additional	additional	ADJ
admet-1022	22	10	drug	drug	NOUN
admet-1022	22	11	-	-	PUNCT
admet-1022	22	12	like	like	ADJ
admet-1022	22	13	properties	property	NOUN
admet-1022	22	14	such	such	ADJ
admet-1022	22	15	as	as	ADP
admet-1022	22	16	a	a	DET
admet-1022	22	17	number	number	NOUN
admet-1022	22	18	of	of	ADP
admet-1022	22	19	rotatable	rotatable	ADJ
admet-1022	22	20	bonds	bond	NOUN
admet-1022	22	21	,	,	PUNCT
admet-1022	22	22	polar	polar	ADJ
admet-1022	22	23	surface	surface	NOUN
admet-1022	22	24	area	area	NOUN
admet-1022	22	25	,	,	PUNCT
admet-1022	22	26	or	or	CCONJ
admet-1022	22	27	a	a	DET
admet-1022	22	28	number	number	NOUN
admet-1022	22	29	of	of	ADP
admet-1022	22	30	aromatic	aromatic	ADJ
admet-1022	22	31	rings	ring	NOUN
admet-1022	22	32	[	[	X
admet-1022	22	33	2,9	2,9	NUM
admet-1022	22	34	-	-	SYM
admet-1022	22	35	11	11	NUM
admet-1022	22	36	]	]	PUNCT
admet-1022	22	37	may	may	AUX
admet-1022	22	38	be	be	AUX
admet-1022	22	39	used	use	VERB
admet-1022	22	40	as	as	ADP
admet-1022	22	41	virtual	virtual	ADJ
admet-1022	22	42	screening	screening	NOUN
admet-1022	22	43	filters	filter	NOUN
admet-1022	22	44	in	in	ADP
admet-1022	22	45	early	early	ADJ
admet-1022	22	46	drug	drug	NOUN
admet-1022	22	47	discovery	discovery	NOUN
admet-1022	22	48	.	.	PUNCT
admet-1022	23	1	however	however	ADV
admet-1022	23	2	,	,	PUNCT
admet-1022	23	3	this	this	DET
admet-1022	23	4	strategy	strategy	NOUN
admet-1022	23	5	has	have	AUX
admet-1022	23	6	been	be	AUX
admet-1022	23	7	recently	recently	ADV
admet-1022	23	8	disputed	dispute	VERB
admet-1022	23	9	,	,	PUNCT
admet-1022	23	10	as	as	SCONJ
admet-1022	23	11	there	there	PRON
admet-1022	23	12	is	be	VERB
admet-1022	23	13	an	an	DET
admet-1022	23	14	increasing	increase	VERB
admet-1022	23	15	interest	interest	NOUN
admet-1022	23	16	in	in	ADP
admet-1022	23	17	exploring	explore	VERB
admet-1022	23	18	beyond	beyond	ADP
admet-1022	23	19	the	the	DET
admet-1022	23	20	rule	rule	NOUN
admet-1022	23	21	of	of	ADP
admet-1022	23	22	five	five	NUM
admet-1022	23	23	(	(	PUNCT
admet-1022	23	24	bro5	bro5	NOUN
admet-1022	23	25	)	)	PUNCT
admet-1022	23	26	chemical	chemical	NOUN
admet-1022	23	27	space	space	NOUN
admet-1022	23	28	in	in	ADP
admet-1022	23	29	drug	drug	NOUN
admet-1022	23	30	discovery	discovery	NOUN
admet-1022	24	1	[	[	X
admet-1022	24	2	12,13	12,13	NUM
admet-1022	24	3	]	]	PUNCT
admet-1022	24	4	.	.	PUNCT
admet-1022	25	1	the	the	DET
admet-1022	25	2	concept	concept	NOUN
admet-1022	25	3	of	of	ADP
admet-1022	25	4	drug	drug	NOUN
admet-1022	25	5	-	-	PUNCT
admet-1022	25	6	likeness	likeness	NOUN
admet-1022	25	7	was	be	AUX
admet-1022	25	8	further	far	ADV
admet-1022	25	9	advanced	advanced	ADJ
admet-1022	25	10	to	to	PART
admet-1022	25	11	address	address	VERB
admet-1022	25	12	drug	drug	NOUN
admet-1022	25	13	safety	safety	NOUN
admet-1022	25	14	by	by	ADP
admet-1022	25	15	normalizing	normalize	VERB
admet-1022	25	16	affinity	affinity	NOUN
admet-1022	25	17	to	to	PART
admet-1022	25	18	size	size	NOUN
admet-1022	25	19	or	or	CCONJ
admet-1022	25	20	/	/	SYM
admet-1022	25	21	and	and	CCONJ
admet-1022	25	22	lipophilicity	lipophilicity	NOUN
admet-1022	25	23	,	,	PUNCT
admet-1022	25	24	as	as	SCONJ
admet-1022	25	25	reflected	reflect	VERB
admet-1022	25	26	in	in	ADP
admet-1022	25	27	metrics	metric	NOUN
admet-1022	25	28	like	like	ADP
admet-1022	25	29	ligand	ligand	NOUN
admet-1022	25	30	efficiency	efficiency	NOUN
admet-1022	25	31	(	(	PUNCT
admet-1022	25	32	le	le	X
admet-1022	25	33	)	)	PUNCT
admet-1022	25	34	,	,	PUNCT
admet-1022	25	35	lipophilic	lipophilic	ADJ
admet-1022	25	36	ligand	ligand	NOUN
admet-1022	25	37	efficiency	efficiency	NOUN
admet-1022	25	38	(	(	PUNCT
admet-1022	25	39	lle	lle	PROPN
admet-1022	25	40	)	)	PUNCT
admet-1022	25	41	and	and	CCONJ
admet-1022	25	42	ligand	ligand	NOUN
admet-1022	25	43	efficiency	efficiency	NOUN
admet-1022	25	44	dependent	dependent	ADJ
admet-1022	25	45	lipophilicity	lipophilicity	NOUN
admet-1022	25	46	(	(	PUNCT
admet-1022	25	47	lelp	lelp	NOUN
admet-1022	25	48	)	)	PUNCT
admet-1022	26	1	[	[	X
admet-1022	26	2	1,14	1,14	NUM
admet-1022	26	3	-	-	SYM
admet-1022	26	4	16	16	NUM
admet-1022	26	5	]	]	PUNCT
admet-1022	26	6	.	.	PUNCT
admet-1022	27	1	on	on	ADP
admet-1022	27	2	the	the	DET
admet-1022	27	3	other	other	ADJ
admet-1022	27	4	hand	hand	NOUN
admet-1022	27	5	,	,	PUNCT
admet-1022	27	6	ghose	ghose	PROPN
admet-1022	27	7	et	et	PROPN
admet-1022	27	8	al	al	PROPN
admet-1022	27	9	.	.	PUNCT
admet-1022	28	1	[	[	X
admet-1022	28	2	17	17	NUM
admet-1022	28	3	]	]	AUX
admet-1022	28	4	suggest	suggest	AUX
admet-1022	28	5	qualifying	qualify	VERB
admet-1022	28	6	ranges	range	NOUN
admet-1022	28	7	of	of	ADP
admet-1022	28	8	-0.4	-0.4	NUM
admet-1022	28	9	to	to	ADP
admet-1022	28	10	5.6	5.6	NUM
admet-1022	28	11	for	for	ADP
admet-1022	28	12	log	log	NOUN
admet-1022	28	13	p	p	NOUN
admet-1022	28	14	and	and	CCONJ
admet-1022	28	15	160	160	NUM
admet-1022	28	16	to	to	ADP
admet-1022	28	17	480	480	NUM
admet-1022	28	18	for	for	ADP
admet-1022	28	19	molecular	molecular	ADJ
admet-1022	28	20	weight	weight	NOUN
admet-1022	28	21	as	as	ADP
admet-1022	28	22	filters	filter	NOUN
admet-1022	28	23	for	for	ADP
admet-1022	28	24	drug	drug	NOUN
admet-1022	28	25	-	-	PUNCT
admet-1022	28	26	likeness	likeness	NOUN
admet-1022	28	27	,	,	PUNCT
admet-1022	28	28	thus	thus	ADV
admet-1022	28	29	setting	set	VERB
admet-1022	28	30	lower	low	ADJ
admet-1022	28	31	limits	limit	NOUN
admet-1022	28	32	lipophilicity	lipophilicity	NOUN
admet-1022	28	33	and	and	CCONJ
admet-1022	28	34	size	size	NOUN
admet-1022	28	35	[	[	X
admet-1022	28	36	17	17	NUM
admet-1022	28	37	]	]	PUNCT
admet-1022	28	38	.	.	PUNCT
admet-1022	29	1	in	in	ADP
admet-1022	29	2	the	the	DET
admet-1022	29	3	above	above	ADJ
admet-1022	29	4	metrics	metric	NOUN
admet-1022	29	5	,	,	PUNCT
admet-1022	29	6	lipophilicity	lipophilicity	NOUN
admet-1022	29	7	is	be	AUX
admet-1022	29	8	expressed	express	VERB
admet-1022	29	9	by	by	ADP
admet-1022	29	10	log	log	NOUN
admet-1022	29	11	p	p	NOUN
admet-1022	29	12	,	,	PUNCT
admet-1022	29	13	which	which	PRON
admet-1022	29	14	corresponds	correspond	VERB
admet-1022	29	15	to	to	ADP
admet-1022	29	16	intrinsic	intrinsic	ADJ
admet-1022	29	17	lipophilicity	lipophilicity	NOUN
admet-1022	29	18	of	of	ADP
admet-1022	29	19	the	the	DET
admet-1022	29	20	neutral	neutral	ADJ
admet-1022	29	21	species	specie	NOUN
admet-1022	29	22	,	,	PUNCT
admet-1022	29	23	ignoring	ignore	VERB
admet-1022	29	24	the	the	DET
admet-1022	29	25	effect	effect	NOUN
admet-1022	29	26	of	of	ADP
admet-1022	29	27	ionization	ionization	NOUN
admet-1022	29	28	in	in	ADP
admet-1022	29	29	the	the	DET
admet-1022	29	30	case	case	NOUN
admet-1022	29	31	of	of	ADP
admet-1022	29	32	drugs	drug	NOUN
admet-1022	29	33	containing	contain	VERB
admet-1022	29	34	ionizable	ionizable	ADJ
admet-1022	29	35	groups	group	NOUN
admet-1022	29	36	.	.	PUNCT
admet-1022	30	1	intrinsic	intrinsic	ADJ
admet-1022	30	2	lipophilicity	lipophilicity	NOUN
admet-1022	30	3	governs	govern	VERB
admet-1022	30	4	hydrophobic	hydrophobic	NOUN
admet-1022	30	5	binding	bind	VERB
admet-1022	30	6	to	to	ADP
admet-1022	30	7	biomacromolecules	biomacromolecule	NOUN
admet-1022	30	8	.	.	PUNCT
admet-1022	31	1	however	however	ADV
admet-1022	31	2	,	,	PUNCT
admet-1022	31	3	permeability	permeability	NOUN
admet-1022	31	4	is	be	AUX
admet-1022	31	5	affected	affect	VERB
admet-1022	31	6	rather	rather	ADV
admet-1022	31	7	by	by	ADP
admet-1022	31	8	apparent	apparent	ADJ
admet-1022	31	9	lipophilicity	lipophilicity	NOUN
admet-1022	31	10	,	,	PUNCT
admet-1022	31	11	log	log	VERB
admet-1022	31	12	d	d	NOUN
admet-1022	31	13	,	,	PUNCT
admet-1022	31	14	as	as	SCONJ
admet-1022	31	15	dictated	dictate	VERB
admet-1022	31	16	by	by	ADP
admet-1022	31	17	the	the	DET
admet-1022	31	18	partition	partition	NOUN
admet-1022	31	19	-	-	PUNCT
admet-1022	31	20	ph	ph	ADJ
admet-1022	31	21	hypothesis	hypothesis	NOUN
admet-1022	31	22	,	,	PUNCT
admet-1022	31	23	although	although	SCONJ
admet-1022	31	24	intrinsic	intrinsic	ADJ
admet-1022	31	25	lipophilicity	lipophilicity	NOUN
admet-1022	31	26	remains	remain	VERB
admet-1022	31	27	the	the	DET
admet-1022	31	28	driving	drive	VERB
admet-1022	31	29	force	force	NOUN
admet-1022	31	30	.	.	PUNCT
admet-1022	32	1	in	in	ADP
admet-1022	32	2	a	a	DET
admet-1022	32	3	retrospective	retrospective	ADJ
admet-1022	32	4	analysis	analysis	NOUN
admet-1022	32	5	of	of	ADP
admet-1022	32	6	human	human	ADJ
admet-1022	32	7	bioavailability	bioavailability	NOUN
admet-1022	32	8	data	datum	NOUN
admet-1022	32	9	,	,	PUNCT
admet-1022	32	10	compounds	compound	VERB
admet-1022	32	11	with	with	ADP
admet-1022	32	12	log	log	NOUN
admet-1022	32	13	d	d	NOUN
admet-1022	32	14	values	value	NOUN
admet-1022	32	15	at	at	ADP
admet-1022	32	16	ph	ph	PROPN
admet-1022	32	17	6.5	6.5	NUM
admet-1022	32	18	in	in	ADP
admet-1022	32	19	the	the	DET
admet-1022	32	20	range	range	NOUN
admet-1022	32	21	of	of	ADP
admet-1022	32	22	-2	-2	NOUN
admet-1022	32	23	to	to	PART
admet-1022	32	24	3	3	NUM
admet-1022	32	25	were	be	AUX
admet-1022	32	26	found	find	VERB
admet-1022	32	27	to	to	PART
admet-1022	32	28	display	display	VERB
admet-1022	32	29	increased	increase	VERB
admet-1022	32	30	bioavailability	bioavailability	NOUN
admet-1022	32	31	[	[	X
admet-1022	32	32	18	18	NUM
admet-1022	32	33	]	]	PUNCT
admet-1022	32	34	.	.	PUNCT
admet-1022	33	1	for	for	ADP
admet-1022	33	2	physiological	physiological	ADJ
admet-1022	33	3	ph	ph	VERB
admet-1022	33	4	,	,	PUNCT
admet-1022	33	5	an	an	DET
admet-1022	33	6	optimum	optimum	ADJ
admet-1022	33	7	log	log	NOUN
admet-1022	33	8	d	d	NOUN
admet-1022	33	9	range	range	NOUN
admet-1022	33	10	between	between	ADP
admet-1022	33	11	1	1	NUM
admet-1022	33	12	-	-	SYM
admet-1022	33	13	3	3	NUM
admet-1022	33	14	has	have	AUX
admet-1022	33	15	been	be	AUX
admet-1022	33	16	proposed	propose	VERB
admet-1022	33	17	[	[	X
admet-1022	33	18	19	19	NUM
admet-1022	33	19	]	]	PUNCT
admet-1022	33	20	,	,	PUNCT
admet-1022	33	21	while	while	SCONJ
admet-1022	33	22	waring	waring	NOUN
admet-1022	33	23	established	establish	VERB
admet-1022	33	24	lower	low	ADJ
admet-1022	33	25	limits	limit	NOUN
admet-1022	33	26	for	for	ADP
admet-1022	33	27	log	log	NOUN
admet-1022	33	28	d7.4	d7.4	PROPN
admet-1022	33	29	in	in	ADP
admet-1022	33	30	a	a	DET
admet-1022	33	31	molecular	molecular	ADJ
admet-1022	33	32	weight	weight	NOUN
admet-1022	33	33	-	-	PUNCT
admet-1022	33	34	dependent	dependent	ADJ
admet-1022	33	35	manner	manner	NOUN
admet-1022	33	36	to	to	PART
admet-1022	33	37	achieve	achieve	VERB
admet-1022	33	38	>	>	PUNCT
admet-1022	33	39	50	50	NUM
admet-1022	33	40	%	%	NOUN
admet-1022	33	41	chance	chance	NOUN
admet-1022	33	42	for	for	ADP
admet-1022	33	43	high	high	ADJ
admet-1022	33	44	permeability	permeability	NOUN
admet-1022	33	45	[	[	X
admet-1022	33	46	20	20	NUM
admet-1022	33	47	]	]	PUNCT
admet-1022	33	48	.	.	PUNCT
admet-1022	34	1	according	accord	VERB
admet-1022	34	2	to	to	ADP
admet-1022	34	3	the	the	DET
admet-1022	34	4	author	author	NOUN
admet-1022	34	5	,	,	PUNCT
admet-1022	34	6	the	the	DET
admet-1022	34	7	log	log	NOUN
admet-1022	34	8	d	d	NOUN
admet-1022	34	9	thresholds	threshold	NOUN
admet-1022	34	10	occur	occur	VERB
admet-1022	34	11	at	at	ADP
admet-1022	34	12	higher	high	ADJ
admet-1022	34	13	values	value	NOUN
admet-1022	34	14	for	for	ADP
admet-1022	34	15	higher	high	ADJ
admet-1022	34	16	molecular	molecular	ADJ
admet-1022	34	17	weight	weight	NOUN
admet-1022	34	18	ranges	range	NOUN
admet-1022	34	19	,	,	PUNCT
admet-1022	34	20	with	with	ADP
admet-1022	34	21	large	large	ADJ
admet-1022	34	22	molecules	molecule	NOUN
admet-1022	34	23	(	(	PUNCT
admet-1022	34	24	mw>500	mw>500	NOUN
admet-1022	34	25	)	)	PUNCT
admet-1022	34	26	necessitating	necessitate	VERB
admet-1022	34	27	log	log	NOUN
admet-1022	34	28	d	d	X
admet-1022	34	29	>	>	X
admet-1022	34	30	4.5	4.5	NUM
admet-1022	34	31	.	.	PUNCT
admet-1022	35	1	analogous	analogous	ADJ
admet-1022	35	2	results	result	NOUN
admet-1022	35	3	on	on	ADP
admet-1022	35	4	the	the	DET
admet-1022	35	5	dependence	dependence	NOUN
admet-1022	35	6	of	of	ADP
admet-1022	35	7	optimal	optimal	ADJ
admet-1022	35	8	log	log	NOUN
admet-1022	35	9	d	d	NOUN
admet-1022	35	10	ranges	range	VERB
admet-1022	35	11	on	on	ADP
admet-1022	35	12	molecular	molecular	ADJ
admet-1022	35	13	weight	weight	NOUN
admet-1022	35	14	were	be	AUX
admet-1022	35	15	also	also	ADV
admet-1022	35	16	reported	report	VERB
admet-1022	35	17	by	by	ADP
admet-1022	35	18	other	other	ADJ
admet-1022	35	19	authors	author	NOUN
admet-1022	35	20	[	[	X
admet-1022	35	21	21	21	NUM
admet-1022	35	22	]	]	PUNCT
admet-1022	35	23	.	.	PUNCT
admet-1022	36	1	the	the	DET
admet-1022	36	2	above	above	ADJ
admet-1022	36	3	suggestions	suggestion	NOUN
admet-1022	36	4	underestimate	underestimate	VERB
admet-1022	36	5	the	the	DET
admet-1022	36	6	role	role	NOUN
admet-1022	36	7	of	of	ADP
admet-1022	36	8	intrinsic	intrinsic	ADJ
admet-1022	36	9	lipophilicity	lipophilicity	NOUN
admet-1022	36	10	,	,	PUNCT
admet-1022	36	11	although	although	SCONJ
admet-1022	36	12	the	the	DET
admet-1022	36	13	dependence	dependence	NOUN
admet-1022	36	14	of	of	ADP
admet-1022	36	15	log	log	NOUN
admet-1022	36	16	d	d	NOUN
admet-1022	36	17	to	to	ADP
admet-1022	36	18	molecular	molecular	ADJ
admet-1022	36	19	weight	weight	NOUN
admet-1022	36	20	in	in	ADP
admet-1022	36	21	waring	waring	NOUN
admet-1022	36	22	’s	’s	PART
admet-1022	36	23	approach	approach	NOUN
admet-1022	36	24	indirectly	indirectly	ADV
admet-1022	36	25	introduces	introduce	VERB
admet-1022	36	26	the	the	DET
admet-1022	36	27	bulk	bulk	ADJ
admet-1022	36	28	component	component	NOUN
admet-1022	36	29	,	,	PUNCT
admet-1022	36	30	which	which	PRON
admet-1022	36	31	is	be	AUX
admet-1022	36	32	related	relate	VERB
admet-1022	36	33	to	to	ADP
admet-1022	36	34	the	the	DET
admet-1022	36	35	hydrophobicity	hydrophobicity	NOUN
admet-1022	36	36	of	of	ADP
admet-1022	36	37	the	the	DET
admet-1022	36	38	molecule	molecule	NOUN
admet-1022	36	39	,	,	PUNCT
admet-1022	36	40	according	accord	VERB
admet-1022	36	41	to	to	ADP
admet-1022	36	42	the	the	DET
admet-1022	36	43	dual	dual	ADJ
admet-1022	36	44	nature	nature	NOUN
admet-1022	36	45	of	of	ADP
admet-1022	36	46	lipophilicity	lipophilicity	NOUN
admet-1022	36	47	[	[	X
admet-1022	36	48	22	22	NUM
admet-1022	36	49	]	]	PUNCT
admet-1022	36	50	.	.	PUNCT
admet-1022	37	1	moreover	moreover	ADV
admet-1022	37	2	,	,	PUNCT
admet-1022	37	3	since	since	SCONJ
admet-1022	37	4	log	log	NOUN
admet-1022	37	5	d	d	NOUN
admet-1022	37	6	values	value	NOUN
admet-1022	37	7	depend	depend	VERB
admet-1022	37	8	on	on	ADP
admet-1022	37	9	log	log	NOUN
admet-1022	37	10	p	p	X
admet-1022	37	11	,	,	PUNCT
admet-1022	37	12	their	their	PRON
admet-1022	37	13	magnitude	magnitude	NOUN
admet-1022	37	14	alone	alone	ADV
admet-1022	37	15	does	do	AUX
admet-1022	37	16	not	not	PART
admet-1022	37	17	provide	provide	VERB
admet-1022	37	18	information	information	NOUN
admet-1022	37	19	of	of	ADP
admet-1022	37	20	the	the	DET
admet-1022	37	21	degree	degree	NOUN
admet-1022	37	22	of	of	ADP
admet-1022	37	23	ionization	ionization	NOUN
admet-1022	37	24	.	.	PUNCT
admet-1022	38	1	a	a	DET
admet-1022	38	2	specific	specific	ADJ
admet-1022	38	3	log	log	NOUN
admet-1022	38	4	d	d	NOUN
admet-1022	38	5	value	value	NOUN
admet-1022	38	6	may	may	AUX
admet-1022	38	7	correspond	correspond	VERB
admet-1022	38	8	to	to	PART
admet-1022	38	9	log	log	VERB
admet-1022	38	10	p	p	NOUN
admet-1022	38	11	values	value	NOUN
admet-1022	38	12	spanning	span	VERB
admet-1022	38	13	within	within	ADP
admet-1022	38	14	3	3	NUM
admet-1022	38	15	log	log	NOUN
admet-1022	38	16	units	unit	NOUN
admet-1022	38	17	,	,	PUNCT
admet-1022	38	18	considering	consider	VERB
admet-1022	38	19	that	that	SCONJ
admet-1022	38	20	this	this	PRON
admet-1022	38	21	is	be	AUX
admet-1022	38	22	the	the	DET
admet-1022	38	23	difference	difference	NOUN
admet-1022	38	24	between	between	ADP
admet-1022	38	25	log	log	NOUN
admet-1022	38	26	p	p	NOUN
admet-1022	38	27	of	of	ADP
admet-1022	38	28	the	the	DET
admet-1022	38	29	neutral	neutral	ADJ
admet-1022	38	30	and	and	CCONJ
admet-1022	38	31	fully	fully	ADV
admet-1022	38	32	ionized	ionized	ADJ
admet-1022	38	33	species	specie	NOUN
admet-1022	38	34	.	.	PUNCT
admet-1022	39	1	recently	recently	ADV
admet-1022	39	2	,	,	PUNCT
admet-1022	39	3	we	we	PRON
admet-1022	39	4	have	have	AUX
admet-1022	39	5	developed	develop	VERB
admet-1022	39	6	a	a	DET
admet-1022	39	7	new	new	ADJ
admet-1022	39	8	metric	metric	NOUN
admet-1022	39	9	for	for	ADP
admet-1022	39	10	assessing	assess	VERB
admet-1022	39	11	oral	oral	ADJ
admet-1022	39	12	drug	drug	NOUN
admet-1022	39	13	-	-	PUNCT
admet-1022	39	14	likeness	likeness	NOUN
admet-1022	39	15	of	of	ADP
admet-1022	39	16	ionizable	ionizable	ADJ
admet-1022	39	17	chemical	chemical	NOUN
admet-1022	39	18	entities	entity	NOUN
admet-1022	39	19	as	as	ADP
admet-1022	39	20	a	a	DET
admet-1022	39	21	weighted	weight	VERB
admet-1022	39	22	combination	combination	NOUN
admet-1022	39	23	of	of	ADP
admet-1022	39	24	both	both	PRON
admet-1022	39	25	log	log	VERB
admet-1022	39	26	p	p	NOUN
admet-1022	39	27	and	and	CCONJ
admet-1022	39	28	log	log	VERB
admet-1022	39	29	d	d	PROPN
admet-1022	39	30	,	,	PUNCT
admet-1022	39	31	considering	consider	VERB
admet-1022	39	32	that	that	SCONJ
admet-1022	39	33	the	the	DET
admet-1022	39	34	two	two	NUM
admet-1022	39	35	measures	measure	NOUN
admet-1022	39	36	have	have	VERB
admet-1022	39	37	a	a	DET
admet-1022	39	38	distinct	distinct	ADJ
admet-1022	39	39	role	role	NOUN
admet-1022	39	40	to	to	PART
admet-1022	39	41	play	play	VERB
admet-1022	39	42	[	[	X
admet-1022	39	43	23,24	23,24	NUM
admet-1022	39	44	]	]	PUNCT
admet-1022	39	45	.	.	PUNCT
admet-1022	40	1	we	we	PRON
admet-1022	40	2	refer	refer	VERB
admet-1022	40	3	to	to	ADP
admet-1022	40	4	this	this	DET
admet-1022	40	5	metric	metric	NOUN
admet-1022	40	6	as	as	ADP
admet-1022	40	7	fraction	fraction	NOUN
admet-1022	40	8	lipophilicity	lipophilicity	NOUN
admet-1022	40	9	index	index	NOUN
admet-1022	40	10	(	(	PUNCT
admet-1022	40	11	fli	fli	NOUN
admet-1022	40	12	)	)	PUNCT
admet-1022	40	13	.	.	PUNCT
admet-1022	41	1	fli	fli	NOUN
admet-1022	41	2	is	be	AUX
admet-1022	41	3	defined	define	VERB
admet-1022	41	4	as	as	ADP
admet-1022	41	5	the	the	DET
admet-1022	41	6	logarithm	logarithm	NOUN
admet-1022	41	7	of	of	ADP
admet-1022	41	8	the	the	DET
admet-1022	41	9	quotient	quotient	NOUN
admet-1022	41	10	of	of	ADP
admet-1022	41	11	partition	partition	NOUN
admet-1022	41	12	coefficients	coefficient	NOUN
admet-1022	41	13	(	(	PUNCT
admet-1022	41	14	p	p	NOUN
admet-1022	41	15	)	)	PUNCT
admet-1022	41	16	and	and	CCONJ
admet-1022	41	17	the	the	DET
admet-1022	41	18	fraction	fraction	NOUN
admet-1022	41	19	of	of	ADP
admet-1022	41	20	the	the	DET
admet-1022	41	21	neutral	neutral	ADJ
admet-1022	41	22	form	form	NOUN
admet-1022	41	23	(	(	PUNCT
admet-1022	41	24	fn	fn	NOUN
admet-1022	41	25	)	)	PUNCT
admet-1022	41	26	at	at	ADP
admet-1022	41	27	a	a	DET
admet-1022	41	28	given	give	VERB
admet-1022	41	29	ph	ph	PROPN
admet-1022	41	30	(	(	PUNCT
admet-1022	41	31	i.e.	i.e.	X
admet-1022	41	32	,	,	PUNCT
admet-1022	41	33	log(p	log(p	PROPN
admet-1022	41	34	/	/	SYM
admet-1022	41	35	fn	fn	NOUN
admet-1022	41	36	)	)	PUNCT
admet-1022	41	37	)	)	PUNCT
admet-1022	41	38	,	,	PUNCT
admet-1022	41	39	which	which	PRON
admet-1022	41	40	upon	upon	SCONJ
admet-1022	41	41	analyzing	analyze	VERB
admet-1022	41	42	log	log	NOUN
admet-1022	41	43	fn	fn	NOUN
admet-1022	41	44	leads	lead	VERB
admet-1022	41	45	to	to	ADP
admet-1022	41	46	equation	equation	NOUN
admet-1022	41	47	1	1	NUM
admet-1022	41	48	:	:	PUNCT
admet-1022	41	49	fli	fli	NOUN
admet-1022	41	50	=	=	SYM
admet-1022	41	51	2log	2log	PROPN
admet-1022	41	52	p	p	NOUN
admet-1022	41	53	-	-	PUNCT
admet-1022	41	54	log	log	NOUN
admet-1022	41	55	d	d	X
admet-1022	41	56	(	(	PUNCT
admet-1022	41	57	1	1	NUM
admet-1022	41	58	)	)	PUNCT
admet-1022	41	59	eq.1	eq.1	PROPN
admet-1022	41	60	was	be	AUX
admet-1022	41	61	further	far	ADV
admet-1022	41	62	modified	modify	VERB
admet-1022	41	63	to	to	ADP
admet-1022	41	64	eq	eq	NOUN
admet-1022	41	65	.	.	PROPN
admet-1022	41	66	2	2	NUM
admet-1022	41	67	by	by	ADP
admet-1022	41	68	considering	consider	VERB
admet-1022	41	69	the	the	DET
admet-1022	41	70	absolute	absolute	ADJ
admet-1022	41	71	value	value	NOUN
admet-1022	41	72	of	of	ADP
admet-1022	41	73	log	log	PROPN
admet-1022	41	74	d.	d.	PROPN
admet-1022	41	75	this	this	DET
admet-1022	41	76	modification	modification	NOUN
admet-1022	41	77	was	be	AUX
admet-1022	41	78	assumed	assume	VERB
admet-1022	41	79	necessary	necessary	ADJ
admet-1022	41	80	since	since	SCONJ
admet-1022	41	81	negative	negative	ADJ
admet-1022	41	82	log	log	NOUN
admet-1022	41	83	d	d	NOUN
admet-1022	41	84	values	value	NOUN
admet-1022	41	85	,	,	PUNCT
admet-1022	41	86	although	although	SCONJ
admet-1022	41	87	unfavorable	unfavorable	ADJ
admet-1022	41	88	for	for	ADP
admet-1022	41	89	absorption	absorption	NOUN
admet-1022	41	90	,	,	PUNCT
admet-1022	41	91	contribute	contribute	VERB
admet-1022	41	92	positively	positively	ADV
admet-1022	41	93	to	to	ADP
admet-1022	41	94	fli	fli	ADJ
admet-1022	41	95	calculation	calculation	NOUN
admet-1022	41	96	shifting	shift	VERB
admet-1022	41	97	the	the	DET
admet-1022	41	98	values	value	NOUN
admet-1022	41	99	to	to	ADP
admet-1022	41	100	the	the	DET
admet-1022	41	101	center	center	NOUN
admet-1022	41	102	of	of	ADP
admet-1022	41	103	the	the	DET
admet-1022	41	104	fli	fli	ADJ
admet-1022	41	105	range	range	NOUN
admet-1022	41	106	.	.	PUNCT
admet-1022	42	1	fli	fli	NOUN
admet-1022	42	2	=	=	SYM
admet-1022	42	3	2log	2log	PROPN
admet-1022	42	4	p	p	NOUN
admet-1022	42	5	│	│	NOUN
admet-1022	42	6	log	log	NOUN
admet-1022	42	7	d	d	NOUN
admet-1022	42	8	│	│	X
admet-1022	42	9	(	(	PUNCT
admet-1022	42	10	2	2	NUM
admet-1022	42	11	)	)	PUNCT
admet-1022	42	12	admet	admet	PROPN
admet-1022	42	13	&	&	CCONJ
admet-1022	42	14	dmpk	dmpk	PROPN
admet-1022	42	15	9(3	9(3	NUM
admet-1022	42	16	)	)	PUNCT
admet-1022	42	17	(	(	PUNCT
admet-1022	42	18	2021	2021	NUM
admet-1022	42	19	)	)	PUNCT
admet-1022	42	20	177	177	NUM
admet-1022	42	21	-	-	SYM
admet-1022	42	22	190	190	NUM
admet-1022	42	23	drug	drug	NOUN
admet-1022	42	24	-	-	PUNCT
admet-1022	42	25	likeness	likeness	NOUN
admet-1022	42	26	and	and	CCONJ
admet-1022	42	27	fraction	fraction	NOUN
admet-1022	42	28	lipophilicity	lipophilicity	PROPN
admet-1022	42	29	index	index	NOUN
admet-1022	42	30	doi	doi	NOUN
admet-1022	42	31	:	:	PUNCT
admet-1022	42	32	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	42	33	179	179	NUM
admet-1022	42	34	the	the	DET
admet-1022	42	35	drug	drug	NOUN
admet-1022	42	36	-	-	PUNCT
admet-1022	42	37	like	like	ADJ
admet-1022	42	38	fli	fli	NOUN
admet-1022	42	39	range	range	NOUN
admet-1022	42	40	0	0	NUM
admet-1022	42	41	-	-	SYM
admet-1022	42	42	8	8	NUM
admet-1022	42	43	,	,	PUNCT
admet-1022	42	44	based	base	VERB
admet-1022	42	45	on	on	ADP
admet-1022	42	46	calculations	calculation	NOUN
admet-1022	42	47	with	with	ADP
admet-1022	42	48	the	the	DET
admet-1022	42	49	medchem	medchem	NOUN
admet-1022	42	50	designer	designer	NOUN
admet-1022	42	51	freeware	freeware	PROPN
admet-1022	42	52	,	,	PUNCT
admet-1022	42	53	was	be	AUX
admet-1022	42	54	found	find	VERB
admet-1022	42	55	to	to	PART
admet-1022	42	56	accommodate	accommodate	VERB
admet-1022	42	57	89	89	NUM
admet-1022	42	58	%	%	NOUN
admet-1022	42	59	of	of	ADP
admet-1022	42	60	drugs	drug	NOUN
admet-1022	42	61	classified	classify	VERB
admet-1022	42	62	as	as	ADP
admet-1022	42	63	highly	highly	ADV
admet-1022	42	64	or	or	CCONJ
admet-1022	42	65	moderately	moderately	ADV
admet-1022	42	66	absorbed	absorb	VERB
admet-1022	42	67	,	,	PUNCT
admet-1022	42	68	with	with	ADP
admet-1022	42	69	the	the	DET
admet-1022	42	70	range	range	NOUN
admet-1022	42	71	5	5	NUM
admet-1022	42	72	to	to	PART
admet-1022	42	73	6	6	NUM
admet-1022	42	74	being	be	AUX
admet-1022	42	75	the	the	DET
admet-1022	42	76	most	most	ADV
admet-1022	42	77	populated	populated	ADJ
admet-1022	42	78	.	.	PUNCT
admet-1022	43	1	there	there	PRON
admet-1022	43	2	is	be	VERB
admet-1022	43	3	a	a	DET
admet-1022	43	4	slight	slight	ADJ
admet-1022	43	5	shift	shift	NOUN
admet-1022	43	6	of	of	ADP
admet-1022	43	7	fli	fli	ADJ
admet-1022	43	8	distribution	distribution	NOUN
admet-1022	43	9	to	to	ADP
admet-1022	43	10	the	the	DET
admet-1022	43	11	upper	upper	ADJ
admet-1022	43	12	limits	limit	NOUN
admet-1022	43	13	of	of	ADP
admet-1022	43	14	the	the	DET
admet-1022	43	15	above	above	ADJ
admet-1022	43	16	range	range	NOUN
admet-1022	43	17	for	for	ADP
admet-1022	43	18	acidic	acidic	ADJ
admet-1022	43	19	compounds	compound	NOUN
admet-1022	43	20	,	,	PUNCT
admet-1022	43	21	which	which	PRON
admet-1022	43	22	is	be	AUX
admet-1022	43	23	restored	restore	VERB
admet-1022	43	24	if	if	SCONJ
admet-1022	43	25	fli@ph5.5	fli@ph5.5	NOUN
admet-1022	43	26	is	be	AUX
admet-1022	43	27	considered	consider	VERB
admet-1022	43	28	.	.	PUNCT
admet-1022	44	1	this	this	PRON
admet-1022	44	2	is	be	AUX
admet-1022	44	3	justified	justify	VERB
admet-1022	44	4	assuming	assume	VERB
admet-1022	44	5	that	that	SCONJ
admet-1022	44	6	absorption	absorption	NOUN
admet-1022	44	7	of	of	ADP
admet-1022	44	8	acids	acid	NOUN
admet-1022	44	9	is	be	AUX
admet-1022	44	10	favored	favor	VERB
admet-1022	44	11	in	in	ADP
admet-1022	44	12	the	the	DET
admet-1022	44	13	upper	upper	ADJ
admet-1022	44	14	part	part	NOUN
admet-1022	44	15	of	of	ADP
admet-1022	44	16	the	the	DET
admet-1022	44	17	intestine	intestine	NOUN
admet-1022	44	18	.	.	PUNCT
admet-1022	45	1	the	the	DET
admet-1022	45	2	same	same	ADJ
admet-1022	45	3	drug	drug	NOUN
admet-1022	45	4	-	-	PUNCT
admet-1022	45	5	like	like	ADJ
admet-1022	45	6	fli	fli	NOUN
admet-1022	45	7	range	range	NOUN
admet-1022	45	8	was	be	AUX
admet-1022	45	9	found	find	VERB
admet-1022	45	10	to	to	PART
admet-1022	45	11	be	be	AUX
admet-1022	45	12	covered	cover	VERB
admet-1022	45	13	by	by	ADP
admet-1022	45	14	73	73	NUM
admet-1022	45	15	%	%	NOUN
admet-1022	45	16	of	of	ADP
admet-1022	45	17	drugs	drug	NOUN
admet-1022	45	18	with	with	ADP
admet-1022	45	19	low	low	ADJ
admet-1022	45	20	absorption	absorption	NOUN
admet-1022	45	21	,	,	PUNCT
admet-1022	45	22	while	while	SCONJ
admet-1022	45	23	fli	fli	ADJ
admet-1022	45	24	distribution	distribution	NOUN
admet-1022	45	25	is	be	AUX
admet-1022	45	26	shifted	shift	VERB
admet-1022	45	27	towards	towards	ADP
admet-1022	45	28	negative	negative	ADJ
admet-1022	45	29	values	value	NOUN
admet-1022	45	30	.	.	PUNCT
admet-1022	46	1	the	the	DET
admet-1022	46	2	present	present	ADJ
admet-1022	46	3	study	study	NOUN
admet-1022	46	4	is	be	AUX
admet-1022	46	5	a	a	DET
admet-1022	46	6	continuation	continuation	NOUN
admet-1022	46	7	of	of	ADP
admet-1022	46	8	our	our	PRON
admet-1022	46	9	previous	previous	ADJ
admet-1022	46	10	investigation	investigation	NOUN
admet-1022	46	11	[	[	X
admet-1022	46	12	23,24	23,24	X
admet-1022	46	13	]	]	PUNCT
admet-1022	46	14	in	in	ADP
admet-1022	46	15	the	the	DET
admet-1022	46	16	aim	aim	NOUN
admet-1022	46	17	to	to	PART
admet-1022	46	18	further	far	ADV
admet-1022	46	19	elaborate	elaborate	VERB
admet-1022	46	20	the	the	DET
admet-1022	46	21	fli	fli	NOUN
admet-1022	46	22	metric	metric	NOUN
admet-1022	46	23	,	,	PUNCT
admet-1022	46	24	extending	extend	VERB
admet-1022	46	25	the	the	DET
admet-1022	46	26	data	datum	NOUN
admet-1022	46	27	set	set	VERB
admet-1022	46	28	to	to	PART
admet-1022	46	29	include	include	VERB
admet-1022	46	30	drugs	drug	NOUN
admet-1022	46	31	approved	approve	VERB
admet-1022	46	32	till	till	SCONJ
admet-1022	46	33	december	december	PROPN
admet-1022	46	34	2020	2020	NUM
admet-1022	46	35	,	,	PUNCT
admet-1022	46	36	as	as	ADV
admet-1022	46	37	well	well	ADV
admet-1022	46	38	as	as	ADP
admet-1022	46	39	a	a	DET
admet-1022	46	40	larger	large	ADJ
admet-1022	46	41	number	number	NOUN
admet-1022	46	42	of	of	ADP
admet-1022	46	43	older	old	ADJ
admet-1022	46	44	drugs	drug	NOUN
admet-1022	46	45	,	,	PUNCT
admet-1022	46	46	while	while	SCONJ
admet-1022	46	47	using	use	VERB
admet-1022	46	48	two	two	NUM
admet-1022	46	49	additional	additional	ADJ
admet-1022	46	50	log	log	NOUN
admet-1022	46	51	p	p	NOUN
admet-1022	46	52	calculation	calculation	NOUN
admet-1022	46	53	systems	system	NOUN
admet-1022	46	54	,	,	PUNCT
admet-1022	46	55	namely	namely	ADV
admet-1022	46	56	clogp	clogp	VERB
admet-1022	46	57	for	for	ADP
admet-1022	46	58	direct	direct	ADJ
admet-1022	46	59	comparison	comparison	NOUN
admet-1022	46	60	with	with	ADP
admet-1022	46	61	lipinski	lipinski	PROPN
admet-1022	46	62	’s	’s	PART
admet-1022	46	63	ro5	ro5	ADJ
admet-1022	46	64	and	and	CCONJ
admet-1022	46	65	mlogp	mlogp	NOUN
admet-1022	46	66	for	for	ADP
admet-1022	46	67	which	which	PRON
admet-1022	46	68	an	an	DET
admet-1022	46	69	upper	upper	ADJ
admet-1022	46	70	limit	limit	NOUN
admet-1022	46	71	4.15	4.15	NUM
admet-1022	46	72	is	be	AUX
admet-1022	46	73	suggested	suggest	VERB
admet-1022	46	74	.	.	PUNCT
admet-1022	47	1	the	the	DET
admet-1022	47	2	dependence	dependence	NOUN
admet-1022	47	3	of	of	ADP
admet-1022	47	4	the	the	DET
admet-1022	47	5	degree	degree	NOUN
admet-1022	47	6	of	of	ADP
admet-1022	47	7	ionization	ionization	NOUN
admet-1022	47	8	to	to	ADP
admet-1022	47	9	intrinsic	intrinsic	ADJ
admet-1022	47	10	lipophilicity	lipophilicity	NOUN
admet-1022	47	11	within	within	ADP
admet-1022	47	12	the	the	DET
admet-1022	47	13	drug	drug	NOUN
admet-1022	47	14	-	-	PUNCT
admet-1022	47	15	like	like	ADJ
admet-1022	47	16	space	space	NOUN
admet-1022	47	17	and	and	CCONJ
admet-1022	47	18	the	the	DET
admet-1022	47	19	inter	inter	NOUN
admet-1022	47	20	-	-	NOUN
admet-1022	47	21	relation	relation	NOUN
admet-1022	47	22	between	between	ADP
admet-1022	47	23	the	the	DET
admet-1022	47	24	ro5	ro5	ADJ
admet-1022	47	25	properties	property	NOUN
admet-1022	47	26	are	be	AUX
admet-1022	47	27	explored	explore	VERB
admet-1022	47	28	to	to	PART
admet-1022	47	29	define	define	VERB
admet-1022	47	30	drug	drug	NOUN
admet-1022	47	31	-	-	PUNCT
admet-1022	47	32	like	like	ADJ
admet-1022	47	33	/	/	SYM
admet-1022	47	34	non	non	ADJ
admet-1022	47	35	-	-	ADJ
admet-1022	47	36	drug	drug	ADJ
admet-1022	47	37	-	-	PUNCT
admet-1022	47	38	like	like	ADJ
admet-1022	47	39	combinations	combination	NOUN
admet-1022	47	40	as	as	ADP
admet-1022	47	41	a	a	DET
admet-1022	47	42	safer	safe	ADJ
admet-1022	47	43	alternative	alternative	NOUN
admet-1022	47	44	to	to	ADP
admet-1022	47	45	single	single	ADJ
admet-1022	47	46	properties	property	NOUN
admet-1022	47	47	for	for	ADP
admet-1022	47	48	drug	drug	NOUN
admet-1022	47	49	candidates	candidate	NOUN
admet-1022	47	50	’	'	PUNCT
admet-1022	47	51	prioritization	prioritization	NOUN
admet-1022	47	52	,	,	PUNCT
admet-1022	47	53	integrating	integrate	VERB
admet-1022	47	54	fli	fli	NOUN
admet-1022	47	55	in	in	ADP
admet-1022	47	56	this	this	DET
admet-1022	47	57	perspective	perspective	NOUN
admet-1022	47	58	.	.	PUNCT
admet-1022	48	1	materials	material	NOUN
admet-1022	48	2	and	and	CCONJ
admet-1022	48	3	methods	method	NOUN
admet-1022	48	4	the	the	DET
admet-1022	48	5	entire	entire	ADJ
admet-1022	48	6	dataset	dataset	NOUN
admet-1022	48	7	comprises	comprise	NOUN
admet-1022	48	8	643	643	NUM
admet-1022	48	9	drugs	drug	NOUN
admet-1022	48	10	,	,	PUNCT
admet-1022	48	11	presented	present	VERB
admet-1022	48	12	in	in	ADP
admet-1022	48	13	table	table	NOUN
admet-1022	48	14	1s	1s	NUM
admet-1022	48	15	,	,	PUNCT
admet-1022	48	16	in	in	ADP
admet-1022	48	17	supplementary	supplementary	ADJ
admet-1022	48	18	material	material	NOUN
admet-1022	48	19	along	along	ADP
admet-1022	48	20	with	with	ADP
admet-1022	48	21	their	their	PRON
admet-1022	48	22	smiles	smile	NOUN
admet-1022	48	23	.	.	PUNCT
admet-1022	49	1	it	it	PRON
admet-1022	49	2	includes	include	VERB
admet-1022	49	3	all	all	DET
admet-1022	49	4	drugs	drug	NOUN
admet-1022	49	5	analyzed	analyze	VERB
admet-1022	49	6	in	in	ADP
admet-1022	49	7	our	our	PRON
admet-1022	49	8	previous	previous	ADJ
admet-1022	49	9	publication	publication	NOUN
admet-1022	49	10	[	[	X
admet-1022	49	11	24	24	NUM
admet-1022	49	12	]	]	PUNCT
admet-1022	49	13	,	,	PUNCT
admet-1022	49	14	drugs	drug	NOUN
admet-1022	49	15	compiled	compile	VERB
admet-1022	49	16	by	by	ADP
admet-1022	49	17	newby	newby	PROPN
admet-1022	49	18	et	et	PROPN
admet-1022	49	19	al	al	PROPN
admet-1022	49	20	.	.	PUNCT
admet-1022	50	1	[	[	X
admet-1022	50	2	25	25	NUM
admet-1022	50	3	]	]	PUNCT
admet-1022	50	4	,	,	PUNCT
admet-1022	50	5	and	and	CCONJ
admet-1022	50	6	later	later	ADV
admet-1022	50	7	generation	generation	NOUN
admet-1022	50	8	drugs	drug	NOUN
admet-1022	50	9	approved	approve	VERB
admet-1022	50	10	in	in	ADP
admet-1022	50	11	2017	2017	NUM
admet-1022	50	12	-	-	SYM
admet-1022	50	13	2020	2020	NUM
admet-1022	50	14	.	.	PUNCT
admet-1022	51	1	all	all	DET
admet-1022	51	2	drugs	drug	NOUN
admet-1022	51	3	included	include	VERB
admet-1022	51	4	in	in	ADP
admet-1022	51	5	the	the	DET
admet-1022	51	6	data	datum	NOUN
admet-1022	51	7	set	set	VERB
admet-1022	51	8	possess	possess	VERB
admet-1022	51	9	ionizable	ionizable	ADJ
admet-1022	51	10	centers	center	NOUN
admet-1022	51	11	and	and	CCONJ
admet-1022	51	12	display	display	VERB
admet-1022	51	13	a	a	DET
admet-1022	51	14	degree	degree	NOUN
admet-1022	51	15	of	of	ADP
admet-1022	51	16	ionization	ionization	NOUN
admet-1022	51	17	at	at	ADP
admet-1022	51	18	ph	ph	PROPN
admet-1022	51	19	7.4	7.4	NUM
admet-1022	51	20	for	for	ADP
admet-1022	51	21	bases	basis	NOUN
admet-1022	51	22	and	and	CCONJ
admet-1022	51	23	ph	ph	VERB
admet-1022	51	24	5.5	5.5	NUM
admet-1022	51	25	for	for	ADP
admet-1022	51	26	acids	acid	NOUN
admet-1022	51	27	higher	high	ADJ
admet-1022	51	28	than	than	ADP
admet-1022	51	29	30	30	NUM
admet-1022	51	30	%	%	NOUN
admet-1022	51	31	,	,	PUNCT
admet-1022	51	32	corresponding	correspond	VERB
admet-1022	51	33	to	to	ADP
admet-1022	51	34	a	a	DET
admet-1022	51	35	difference	difference	NOUN
admet-1022	51	36	δ(log	δ(log	NOUN
admet-1022	51	37	p	p	NOUN
admet-1022	51	38	-	-	PUNCT
admet-1022	51	39	log	log	NOUN
admet-1022	51	40	d	d	NOUN
admet-1022	51	41	)	)	PUNCT
admet-1022	51	42	>	>	X
admet-1022	51	43	0.14	0.14	NUM
admet-1022	51	44	.	.	PUNCT
admet-1022	52	1	depending	depend	VERB
admet-1022	52	2	on	on	ADP
admet-1022	52	3	their	their	PRON
admet-1022	52	4	isoelectric	isoelectric	ADJ
admet-1022	52	5	point	point	NOUN
admet-1022	52	6	,	,	PUNCT
admet-1022	52	7	zwitterions	zwitterion	NOUN
admet-1022	52	8	were	be	AUX
admet-1022	52	9	considered	consider	VERB
admet-1022	52	10	if	if	SCONJ
admet-1022	52	11	log	log	VERB
admet-1022	52	12	dmax	dmax	VERB
admet-1022	52	13	>	>	X
admet-1022	52	14	0.14	0.14	NUM
admet-1022	52	15	than	than	ADP
admet-1022	52	16	log	log	NOUN
admet-1022	52	17	d	d	NOUN
admet-1022	52	18	at	at	ADP
admet-1022	52	19	ph	ph	PROPN
admet-1022	52	20	7.4	7.4	NUM
admet-1022	52	21	or	or	CCONJ
admet-1022	52	22	ph	ph	ADJ
admet-1022	52	23	5.5	5.5	NUM
admet-1022	52	24	.	.	PUNCT
admet-1022	53	1	the	the	DET
admet-1022	53	2	dataset	dataset	NOUN
admet-1022	53	3	is	be	AUX
admet-1022	53	4	split	split	VERB
admet-1022	53	5	into	into	ADP
admet-1022	53	6	two	two	NUM
admet-1022	53	7	classes	class	NOUN
admet-1022	53	8	according	accord	VERB
admet-1022	53	9	to	to	ADP
admet-1022	53	10	their	their	PRON
admet-1022	53	11	fraction	fraction	NOUN
admet-1022	53	12	absorbed	absorb	VERB
admet-1022	53	13	(	(	PUNCT
admet-1022	53	14	%	%	INTJ
admet-1022	53	15	fa	fa	NOUN
admet-1022	53	16	)	)	PUNCT
admet-1022	53	17	taken	take	VERB
admet-1022	53	18	from	from	ADP
admet-1022	53	19	newby	newby	NOUN
admet-1022	53	20	’s	’s	PART
admet-1022	53	21	compilation	compilation	NOUN
admet-1022	54	1	[	[	X
admet-1022	54	2	25	25	NUM
admet-1022	54	3	]	]	PUNCT
admet-1022	54	4	.	.	PUNCT
admet-1022	55	1	fraction	fraction	NOUN
admet-1022	55	2	absorbed	absorb	VERB
admet-1022	55	3	was	be	AUX
admet-1022	55	4	considered	consider	VERB
admet-1022	55	5	more	more	ADV
admet-1022	55	6	appropriate	appropriate	ADJ
admet-1022	55	7	than	than	ADP
admet-1022	55	8	bioavailability	bioavailability	NOUN
admet-1022	55	9	,	,	PUNCT
admet-1022	55	10	used	use	VERB
admet-1022	55	11	in	in	ADP
admet-1022	55	12	our	our	PRON
admet-1022	55	13	previous	previous	ADJ
admet-1022	55	14	publications	publication	NOUN
admet-1022	55	15	,	,	PUNCT
admet-1022	55	16	since	since	SCONJ
admet-1022	55	17	the	the	DET
admet-1022	55	18	latter	latter	ADJ
admet-1022	55	19	is	be	AUX
admet-1022	55	20	a	a	DET
admet-1022	55	21	composite	composite	ADJ
admet-1022	55	22	parameter	parameter	NOUN
admet-1022	55	23	involving	involve	VERB
admet-1022	55	24	several	several	ADJ
admet-1022	55	25	factors	factor	NOUN
admet-1022	55	26	,	,	PUNCT
admet-1022	55	27	such	such	ADJ
admet-1022	55	28	as	as	ADP
admet-1022	55	29	gastrointestinal	gastrointestinal	ADJ
admet-1022	55	30	absorption	absorption	NOUN
admet-1022	55	31	,	,	PUNCT
admet-1022	55	32	chemical	chemical	NOUN
admet-1022	55	33	stability	stability	NOUN
admet-1022	55	34	,	,	PUNCT
admet-1022	55	35	and	and	CCONJ
admet-1022	55	36	the	the	DET
admet-1022	55	37	first	first	ADJ
admet-1022	55	38	-	-	PUNCT
admet-1022	55	39	pass	pass	NOUN
admet-1022	55	40	effect	effect	NOUN
admet-1022	55	41	.	.	PUNCT
admet-1022	56	1	for	for	ADP
admet-1022	56	2	classification	classification	NOUN
admet-1022	56	3	to	to	ADP
admet-1022	56	4	class	class	NOUN
admet-1022	56	5	1	1	NUM
admet-1022	56	6	(	(	PUNCT
admet-1022	56	7	highly	highly	ADV
admet-1022	56	8	and	and	CCONJ
admet-1022	56	9	medium	medium	ADJ
admet-1022	56	10	absorbed	absorb	VERB
admet-1022	56	11	drugs	drug	NOUN
admet-1022	56	12	)	)	PUNCT
admet-1022	56	13	and	and	CCONJ
admet-1022	56	14	class	class	NOUN
admet-1022	56	15	2	2	NUM
admet-1022	56	16	(	(	PUNCT
admet-1022	56	17	poorly	poorly	ADV
admet-1022	56	18	absorbed	absorb	VERB
admet-1022	56	19	drugs	drug	NOUN
admet-1022	56	20	)	)	PUNCT
admet-1022	56	21	,	,	PUNCT
admet-1022	56	22	the	the	DET
admet-1022	56	23	cutoff	cutoff	NOUN
admet-1022	56	24	value	value	NOUN
admet-1022	56	25	was	be	AUX
admet-1022	56	26	set	set	VERB
admet-1022	56	27	at	at	ADP
admet-1022	56	28	45	45	NUM
admet-1022	56	29	%	%	NOUN
admet-1022	56	30	fa	fa	INTJ
admet-1022	56	31	.	.	PUNCT
admet-1022	57	1	drugs	drug	NOUN
admet-1022	57	2	in	in	ADP
admet-1022	57	3	class	class	NOUN
admet-1022	57	4	1	1	NUM
admet-1022	57	5	are	be	AUX
admet-1022	57	6	designated	designate	VERB
admet-1022	57	7	with	with	ADP
admet-1022	57	8	‘	'	PUNCT
admet-1022	57	9	m	m	NOUN
admet-1022	57	10	’	'	PUNCT
admet-1022	57	11	if	if	SCONJ
admet-1022	57	12	%	%	INTJ
admet-1022	57	13	fa	fa	INTJ
admet-1022	57	14	is	be	AUX
admet-1022	57	15	in	in	ADP
admet-1022	57	16	the	the	DET
admet-1022	57	17	range	range	NOUN
admet-1022	57	18	of	of	ADP
admet-1022	57	19	46	46	NUM
admet-1022	57	20	-	-	SYM
admet-1022	57	21	60	60	NUM
admet-1022	57	22	and	and	CCONJ
admet-1022	57	23	with	with	ADP
admet-1022	57	24	‘	'	PUNCT
admet-1022	57	25	h	h	NOUN
admet-1022	57	26	’	'	PUNCT
admet-1022	57	27	if	if	SCONJ
admet-1022	57	28	%	%	INTJ
admet-1022	57	29	fa	fa	INTJ
admet-1022	57	30	is	be	AUX
admet-1022	57	31	higher	high	ADJ
admet-1022	57	32	than	than	ADP
admet-1022	57	33	60	60	NUM
admet-1022	57	34	.	.	PUNCT
admet-1022	58	1	drugs	drug	NOUN
admet-1022	58	2	in	in	ADP
admet-1022	58	3	class	class	NOUN
admet-1022	58	4	2	2	NUM
admet-1022	58	5	are	be	AUX
admet-1022	58	6	designated	designate	VERB
admet-1022	58	7	with	with	ADP
admet-1022	58	8	‘	'	PUNCT
admet-1022	58	9	l	l	NOUN
admet-1022	58	10	’	'	PUNCT
admet-1022	58	11	.	.	PUNCT
admet-1022	59	1	for	for	ADP
admet-1022	59	2	drugs	drug	NOUN
admet-1022	59	3	with	with	ADP
admet-1022	59	4	not	not	PART
admet-1022	59	5	available	available	ADJ
admet-1022	59	6	%	%	INTJ
admet-1022	59	7	fa	fa	INTJ
admet-1022	59	8	in	in	ADP
admet-1022	59	9	ref	ref	NOUN
admet-1022	59	10	[	[	X
admet-1022	59	11	25	25	NUM
admet-1022	59	12	]	]	PUNCT
admet-1022	59	13	,	,	PUNCT
admet-1022	59	14	information	information	NOUN
admet-1022	59	15	on	on	ADP
admet-1022	59	16	absorption	absorption	NOUN
admet-1022	59	17	was	be	AUX
admet-1022	59	18	taken	take	VERB
admet-1022	59	19	from	from	ADP
admet-1022	59	20	drugbank	drugbank	NOUN
admet-1022	59	21	or	or	CCONJ
admet-1022	59	22	other	other	ADJ
admet-1022	59	23	sources	source	NOUN
admet-1022	59	24	,	,	PUNCT
admet-1022	59	25	as	as	SCONJ
admet-1022	59	26	presented	present	VERB
admet-1022	59	27	in	in	ADP
admet-1022	59	28	table	table	NOUN
admet-1022	59	29	1s	1s	NUM
admet-1022	59	30	,	,	PUNCT
admet-1022	59	31	supplementary	supplementary	ADJ
admet-1022	59	32	material	material	NOUN
admet-1022	59	33	.	.	PUNCT
admet-1022	60	1	moreover	moreover	ADV
admet-1022	60	2	,	,	PUNCT
admet-1022	60	3	latest	late	ADJ
admet-1022	60	4	generation	generation	NOUN
admet-1022	60	5	drugs	drug	NOUN
admet-1022	60	6	with	with	ADP
admet-1022	60	7	not	not	PART
admet-1022	60	8	available	available	ADJ
admet-1022	60	9	%	%	INTJ
admet-1022	60	10	fa	fa	PROPN
admet-1022	60	11	data	datum	NOUN
admet-1022	60	12	have	have	AUX
admet-1022	60	13	been	be	AUX
admet-1022	60	14	classified	classify	VERB
admet-1022	60	15	into	into	ADP
admet-1022	60	16	class	class	NOUN
admet-1022	60	17	1	1	NUM
admet-1022	60	18	,	,	PUNCT
admet-1022	60	19	if	if	SCONJ
admet-1022	60	20	they	they	PRON
admet-1022	60	21	are	be	AUX
admet-1022	60	22	administered	administer	VERB
admet-1022	60	23	orally	orally	ADV
admet-1022	60	24	or	or	CCONJ
admet-1022	60	25	to	to	ADP
admet-1022	60	26	class	class	NOUN
admet-1022	60	27	2	2	NUM
admet-1022	60	28	if	if	SCONJ
admet-1022	60	29	other	other	ADJ
admet-1022	60	30	route	route	NOUN
admet-1022	60	31	of	of	ADP
admet-1022	60	32	administration	administration	NOUN
admet-1022	60	33	is	be	AUX
admet-1022	60	34	reported	report	VERB
admet-1022	60	35	.	.	PUNCT
admet-1022	61	1	class	class	NOUN
admet-1022	61	2	1	1	NUM
admet-1022	61	3	comprises	comprise	VERB
admet-1022	61	4	527	527	NUM
admet-1022	61	5	drugs	drug	NOUN
admet-1022	61	6	(	(	PUNCT
admet-1022	61	7	336	336	NUM
admet-1022	61	8	bases	basis	NOUN
admet-1022	61	9	,	,	PUNCT
admet-1022	61	10	178	178	NUM
admet-1022	61	11	acids	acid	NOUN
admet-1022	61	12	and	and	CCONJ
admet-1022	61	13	13	13	NUM
admet-1022	61	14	zwitterions	zwitterion	NOUN
admet-1022	61	15	)	)	PUNCT
admet-1022	61	16	with	with	ADP
admet-1022	61	17	high	high	ADJ
admet-1022	61	18	or	or	CCONJ
admet-1022	61	19	moderate	moderate	ADJ
admet-1022	61	20	absorption	absorption	NOUN
admet-1022	61	21	,	,	PUNCT
admet-1022	61	22	while	while	SCONJ
admet-1022	61	23	class	class	NOUN
admet-1022	61	24	2	2	NUM
admet-1022	61	25	comprises	comprise	VERB
admet-1022	61	26	116	116	NUM
admet-1022	61	27	drugs	drug	NOUN
admet-1022	61	28	(	(	PUNCT
admet-1022	61	29	54	54	NUM
admet-1022	61	30	bases	basis	NOUN
admet-1022	61	31	,	,	PUNCT
admet-1022	61	32	54	54	NUM
admet-1022	61	33	acids	acid	NOUN
admet-1022	61	34	and	and	CCONJ
admet-1022	61	35	8	8	NUM
admet-1022	61	36	zwitterions	zwitterion	NOUN
admet-1022	61	37	)	)	PUNCT
admet-1022	61	38	.	.	PUNCT
admet-1022	62	1	calculation	calculation	NOUN
admet-1022	62	2	of	of	ADP
admet-1022	62	3	fli	fli	ADJ
admet-1022	62	4	partition	partition	NOUN
admet-1022	62	5	coefficients	coefficient	NOUN
admet-1022	62	6	(	(	PUNCT
admet-1022	62	7	logps+	logps+	NOUN
admet-1022	62	8	)	)	PUNCT
admet-1022	62	9	and	and	CCONJ
admet-1022	62	10	distribution	distribution	NOUN
admet-1022	62	11	coefficients	coefficient	NOUN
admet-1022	62	12	at	at	ADP
admet-1022	62	13	physiological	physiological	ADJ
admet-1022	62	14	ph	ph	NOUN
admet-1022	62	15	for	for	ADP
admet-1022	62	16	bases	basis	NOUN
admet-1022	62	17	and	and	CCONJ
admet-1022	62	18	ph	ph	VERB
admet-1022	62	19	5.5	5.5	NUM
admet-1022	62	20	for	for	ADP
admet-1022	62	21	acids	acid	NOUN
admet-1022	62	22	(	(	PUNCT
admet-1022	62	23	logds+	logds+	NOUN
admet-1022	62	24	)	)	PUNCT
admet-1022	62	25	were	be	AUX
admet-1022	62	26	calculated	calculate	VERB
admet-1022	62	27	using	use	VERB
admet-1022	62	28	the	the	DET
admet-1022	62	29	freeware	freeware	NOUN
admet-1022	62	30	medchem	medchem	NOUN
admet-1022	62	31	designer(tm	designer(tm	NOUN
admet-1022	62	32	)	)	PUNCT
admet-1022	62	33	version	version	NOUN
admet-1022	62	34	3.0.0.28	3.0.0.28	NUM
admet-1022	62	35	(	(	PUNCT
admet-1022	62	36	https://www.simulations-plus.com/	https://www.simulations-plus.com/	NOUN
admet-1022	62	37	)	)	PUNCT
admet-1022	62	38	.	.	PUNCT
admet-1022	63	1	the	the	DET
admet-1022	63	2	same	same	ADJ
admet-1022	63	3	program	program	NOUN
admet-1022	63	4	provides	provide	VERB
admet-1022	63	5	log	log	NOUN
admet-1022	63	6	p	p	NOUN
admet-1022	63	7	calculations	calculation	NOUN
admet-1022	63	8	according	accord	VERB
admet-1022	63	9	to	to	ADP
admet-1022	63	10	moriguchi	moriguchi	PROPN
admet-1022	63	11	(	(	PUNCT
admet-1022	63	12	mlogp	mlogp	NOUN
admet-1022	63	13	)	)	PUNCT
admet-1022	64	1	[	[	X
admet-1022	64	2	26	26	NUM
admet-1022	64	3	]	]	PUNCT
admet-1022	64	4	.	.	PUNCT
admet-1022	65	1	for	for	ADP
admet-1022	65	2	direct	direct	ADJ
admet-1022	65	3	comparison	comparison	NOUN
admet-1022	65	4	with	with	ADP
admet-1022	65	5	ro5	ro5	NOUN
admet-1022	65	6	,	,	PUNCT
admet-1022	65	7	the	the	DET
admet-1022	65	8	software	software	NOUN
admet-1022	65	9	clogp	clogp	VERB
admet-1022	65	10	for	for	ADP
admet-1022	65	11	windows	window	NOUN
admet-1022	65	12	v.4.0	v.4.0	X
admet-1022	65	13	[	[	X
admet-1022	65	14	http://www.biobyte.com/	http://www.biobyte.com/	X
admet-1022	65	15	]	]	X
admet-1022	65	16	was	be	AUX
admet-1022	65	17	also	also	ADV
admet-1022	65	18	used	use	VERB
admet-1022	65	19	(	(	PUNCT
admet-1022	65	20	clogp	clogp	ADJ
admet-1022	65	21	)	)	PUNCT
admet-1022	65	22	.	.	PUNCT
admet-1022	66	1	mlogd	mlogd	VERB
admet-1022	66	2	and	and	CCONJ
admet-1022	66	3	clogd	clogd	ADJ
admet-1022	66	4	values	value	NOUN
admet-1022	66	5	were	be	AUX
admet-1022	66	6	assessed	assess	VERB
admet-1022	66	7	considering	consider	VERB
admet-1022	66	8	the	the	DET
admet-1022	66	9	difference	difference	NOUN
admet-1022	66	10	δ(log	δ(log	NOUN
admet-1022	66	11	p	p	NOUN
admet-1022	66	12	–	–	PUNCT
admet-1022	66	13	log	log	NOUN
admet-1022	66	14	d	d	NOUN
admet-1022	66	15	)	)	PUNCT
admet-1022	66	16	generated	generate	VERB
admet-1022	66	17	by	by	ADP
admet-1022	66	18	medchem	medchem	NOUN
admet-1022	66	19	designer	designer	NOUN
admet-1022	66	20	.	.	PUNCT
admet-1022	67	1	δ(log	δ(log	NOUN
admet-1022	67	2	p	p	NOUN
admet-1022	67	3	–	–	PUNCT
admet-1022	67	4	log	log	NOUN
admet-1022	67	5	d	d	NOUN
admet-1022	67	6	)	)	PUNCT
admet-1022	67	7	corresponds	correspond	VERB
admet-1022	67	8	to	to	ADP
admet-1022	67	9	[	[	PUNCT
admet-1022	67	10	log(10±ph	log(10±ph	NOUN
admet-1022	67	11	-	-	PUNCT
admet-1022	67	12	pka)+1	pka)+1	NOUN
admet-1022	67	13	]	]	PUNCT
admet-1022	67	14	and	and	CCONJ
admet-1022	67	15	is	be	AUX
admet-1022	67	16	independent	independent	ADJ
admet-1022	67	17	of	of	ADP
admet-1022	67	18	the	the	DET
admet-1022	67	19	log	log	NOUN
admet-1022	67	20	p	p	NOUN
admet-1022	67	21	calculation	calculation	NOUN
admet-1022	67	22	system	system	NOUN
admet-1022	67	23	.	.	PUNCT
admet-1022	68	1	in	in	ADP
admet-1022	68	2	the	the	DET
admet-1022	68	3	expression	expression	NOUN
admet-1022	68	4	δ(log	δ(log	NOUN
admet-1022	68	5	p	p	NOUN
admet-1022	68	6	–	–	PUNCT
admet-1022	68	7	log	log	NOUN
admet-1022	68	8	d	d	NOUN
admet-1022	68	9	)	)	PUNCT
admet-1022	68	10	,	,	PUNCT
admet-1022	68	11	log	log	PROPN
admet-1022	68	12	d	d	PROPN
admet-1022	68	13	stands	stand	VERB
admet-1022	68	14	for	for	ADP
admet-1022	68	15	log	log	NOUN
admet-1022	68	16	d7.4	d7.4	VERB
admet-1022	68	17	and	and	CCONJ
admet-1022	68	18	log	log	VERB
admet-1022	68	19	d5.5	d5.5	NOUN
admet-1022	68	20	for	for	ADP
admet-1022	68	21	bases	basis	NOUN
admet-1022	68	22	and	and	CCONJ
admet-1022	68	23	acids	acid	NOUN
admet-1022	68	24	,	,	PUNCT
admet-1022	68	25	respectively	respectively	ADV
admet-1022	68	26	.	.	PUNCT
admet-1022	69	1	the	the	DET
admet-1022	69	2	program	program	NOUN
admet-1022	69	3	did	do	AUX
admet-1022	69	4	not	not	PART
admet-1022	69	5	provide	provide	VERB
admet-1022	69	6	calculation	calculation	NOUN
admet-1022	69	7	of	of	ADP
admet-1022	69	8	clogp	clogp	NOUN
admet-1022	69	9	for	for	ADP
admet-1022	69	10	five	five	NUM
admet-1022	69	11	compounds	compound	NOUN
admet-1022	69	12	with	with	ADP
admet-1022	69	13	high	high	ADJ
admet-1022	69	14	mw	mw	X
admet-1022	69	15	(	(	PUNCT
admet-1022	69	16	>	>	NOUN
admet-1022	69	17	1000	1000	NUM
admet-1022	69	18	)	)	PUNCT
admet-1022	69	19	.	.	PUNCT
admet-1022	70	1	for	for	ADP
admet-1022	70	2	these	these	DET
admet-1022	70	3	cases	case	NOUN
admet-1022	70	4	,	,	PUNCT
admet-1022	70	5	clogp	clogp	ADJ
admet-1022	70	6	values	value	NOUN
admet-1022	70	7	were	be	AUX
admet-1022	70	8	predicted	predict	VERB
admet-1022	70	9	using	use	VERB
admet-1022	70	10	eq	eq	ADP
admet-1022	70	11	.	.	PROPN
admet-1022	70	12	3	3	NUM
admet-1022	70	13	which	which	PRON
admet-1022	70	14	reflects	reflect	VERB
admet-1022	70	15	the	the	DET
admet-1022	70	16	correlation	correlation	NOUN
admet-1022	70	17	between	between	ADP
admet-1022	70	18	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	70	19	https://www.simulations-plus.com/	https://www.simulations-plus.com/	ADJ
admet-1022	70	20	https://www.simulations-plus.com/	https://www.simulations-plus.com/	ADJ
admet-1022	70	21	http://www.biobyte.com/	http://www.biobyte.com/	ADJ
admet-1022	70	22	tsantili	tsantili	NOUN
admet-1022	70	23	-	-	PUNCT
admet-1022	70	24	kakoulidou	kakoulidou	NOUN
admet-1022	70	25	and	and	CCONJ
admet-1022	70	26	demopoulos	demopoulos	PROPN
admet-1022	70	27	admet	admet	PROPN
admet-1022	70	28	&	&	CCONJ
admet-1022	70	29	dmpk	dmpk	PROPN
admet-1022	70	30	9(3	9(3	NUM
admet-1022	70	31	)	)	PUNCT
admet-1022	70	32	(	(	PUNCT
admet-1022	70	33	2021	2021	NUM
admet-1022	70	34	)	)	PUNCT
admet-1022	70	35	177	177	NUM
admet-1022	70	36	-	-	SYM
admet-1022	70	37	190	190	NUM
admet-1022	70	38	180	180	NUM
admet-1022	70	39	clogp	clogp	NOUN
admet-1022	70	40	and	and	CCONJ
admet-1022	70	41	logps+	logps+	NOUN
admet-1022	70	42	values	value	NOUN
admet-1022	70	43	.	.	PUNCT
admet-1022	71	1	clogp=1.021(±0.014)logps+	clogp=1.021(±0.014)logps+	NOUN
admet-1022	71	2	+	+	NOUN
admet-1022	71	3	0.014(±0.045	0.014(±0.045	NUM
admet-1022	71	4	)	)	PUNCT
admet-1022	71	5	(	(	PUNCT
admet-1022	71	6	3	3	X
admet-1022	71	7	)	)	PUNCT
admet-1022	71	8	n=626	n=626	PROPN
admet-1022	71	9	r=0.948	r=0.948	NOUN
admet-1022	71	10	s=0.678	s=0.678	NOUN
admet-1022	71	11	equation	equation	NOUN
admet-1022	71	12	3	3	NUM
admet-1022	71	13	practically	practically	ADV
admet-1022	71	14	corresponds	correspond	VERB
admet-1022	71	15	to	to	ADP
admet-1022	71	16	1:1	1:1	NUM
admet-1022	71	17	correlation	correlation	NOUN
admet-1022	71	18	.	.	PUNCT
admet-1022	72	1	the	the	DET
admet-1022	72	2	mean	mean	ADJ
admet-1022	72	3	difference	difference	NOUN
admet-1022	72	4	δ(clogp	δ(clogp	NOUN
admet-1022	72	5	log	log	NOUN
admet-1022	72	6	ps+	ps+	NOUN
admet-1022	72	7	)	)	PUNCT
admet-1022	72	8	is	be	AUX
admet-1022	72	9	0.07	0.07	NUM
admet-1022	72	10	,	,	PUNCT
admet-1022	72	11	although	although	SCONJ
admet-1022	72	12	larger	large	ADJ
admet-1022	72	13	deviations	deviation	NOUN
admet-1022	72	14	are	be	AUX
admet-1022	72	15	observed	observe	VERB
admet-1022	72	16	in	in	ADP
admet-1022	72	17	individual	individual	ADJ
admet-1022	72	18	cases	case	NOUN
admet-1022	72	19	(	(	PUNCT
admet-1022	72	20	table	table	NOUN
admet-1022	72	21	1s	1s	NUM
admet-1022	72	22	,	,	PUNCT
admet-1022	72	23	supplementary	supplementary	ADJ
admet-1022	72	24	material	material	NOUN
admet-1022	72	25	)	)	PUNCT
admet-1022	72	26	.	.	PUNCT
admet-1022	73	1	eq	eq	ADP
admet-1022	73	2	.	.	PROPN
admet-1022	73	3	3	3	NUM
admet-1022	73	4	was	be	AUX
admet-1022	73	5	generated	generate	VERB
admet-1022	73	6	upon	upon	SCONJ
admet-1022	73	7	exclusion	exclusion	NOUN
admet-1022	73	8	of	of	ADP
admet-1022	73	9	16	16	NUM
admet-1022	73	10	drugs	drug	NOUN
admet-1022	73	11	with	with	ADP
admet-1022	73	12	a	a	DET
admet-1022	73	13	high	high	ADJ
admet-1022	73	14	difference	difference	NOUN
admet-1022	73	15	,	,	PUNCT
admet-1022	73	16	│	│	X
admet-1022	73	17	δ(clogp	δ(clogp	NOUN
admet-1022	73	18	logps+	logps+	NOUN
admet-1022	73	19	)	)	PUNCT
admet-1022	73	20	│	│	X
admet-1022	73	21	>	>	X
admet-1022	74	1	2	2	X
admet-1022	74	2	.	.	X
admet-1022	75	1	all	all	DET
admet-1022	75	2	lipophilicity	lipophilicity	NOUN
admet-1022	75	3	data	datum	NOUN
admet-1022	75	4	are	be	AUX
admet-1022	75	5	presented	present	VERB
admet-1022	75	6	in	in	ADP
admet-1022	75	7	table	table	NOUN
admet-1022	75	8	1s	1s	NUM
admet-1022	75	9	,	,	PUNCT
admet-1022	75	10	supplementary	supplementary	ADJ
admet-1022	75	11	material	material	NOUN
admet-1022	75	12	.	.	PUNCT
admet-1022	76	1	in	in	ADP
admet-1022	76	2	the	the	DET
admet-1022	76	3	same	same	ADJ
admet-1022	76	4	table	table	NOUN
admet-1022	76	5	,	,	PUNCT
admet-1022	76	6	molecular	molecular	ADJ
admet-1022	76	7	weight	weight	NOUN
admet-1022	76	8	(	(	PUNCT
admet-1022	76	9	mw	mw	NOUN
admet-1022	76	10	)	)	PUNCT
admet-1022	76	11	,	,	PUNCT
admet-1022	76	12	number	number	NOUN
admet-1022	76	13	of	of	ADP
admet-1022	76	14	hydrogen	hydrogen	NOUN
admet-1022	76	15	bond	bond	NOUN
admet-1022	76	16	donor	donor	NOUN
admet-1022	76	17	(	(	PUNCT
admet-1022	76	18	hd	hd	NOUN
admet-1022	76	19	)	)	PUNCT
admet-1022	76	20	and	and	CCONJ
admet-1022	76	21	acceptor	acceptor	NOUN
admet-1022	76	22	sites	site	NOUN
admet-1022	76	23	(	(	PUNCT
admet-1022	76	24	ha	ha	INTJ
admet-1022	76	25	)	)	PUNCT
admet-1022	76	26	,	,	PUNCT
admet-1022	76	27	designated	designate	VERB
admet-1022	76	28	as	as	ADP
admet-1022	76	29	[	[	X
admet-1022	76	30	n+o	n+o	NUM
admet-1022	76	31	]	]	X
admet-1022	76	32	,	,	PUNCT
admet-1022	76	33	as	as	ADV
admet-1022	76	34	well	well	ADV
admet-1022	76	35	as	as	ADP
admet-1022	76	36	ro5	ro5	ADJ
admet-1022	76	37	violation	violation	NOUN
admet-1022	76	38	scores	score	NOUN
admet-1022	76	39	,	,	PUNCT
admet-1022	76	40	are	be	AUX
admet-1022	76	41	provided	provide	VERB
admet-1022	76	42	.	.	PUNCT
admet-1022	77	1	mw	mw	X
admet-1022	77	2	,	,	PUNCT
admet-1022	77	3	hd	hd	NOUN
admet-1022	77	4	and	and	CCONJ
admet-1022	77	5	[	[	X
admet-1022	77	6	n+o	n+o	X
admet-1022	77	7	]	]	X
admet-1022	77	8	were	be	AUX
admet-1022	77	9	calculated	calculate	VERB
admet-1022	77	10	by	by	ADP
admet-1022	77	11	medchem	medchem	NOUN
admet-1022	77	12	designer	designer	NOUN
admet-1022	77	13	.	.	PUNCT
admet-1022	78	1	ro5	ro5	ADJ
admet-1022	78	2	are	be	AUX
admet-1022	78	3	labeled	label	VERB
admet-1022	78	4	according	accord	VERB
admet-1022	78	5	to	to	ADP
admet-1022	78	6	log	log	VERB
admet-1022	78	7	p	p	NOUN
admet-1022	78	8	calculation	calculation	NOUN
admet-1022	78	9	systems	system	NOUN
admet-1022	78	10	as	as	ADP
admet-1022	78	11	scorero5	scorero5	PROPN
admet-1022	78	12	/	/	SYM
admet-1022	78	13	logps+	logps+	PROPN
admet-1022	78	14	,	,	PUNCT
admet-1022	78	15	scorero5	scorero5	PROPN
admet-1022	78	16	/	/	SYM
admet-1022	78	17	clogp	clogp	NOUN
admet-1022	78	18	and	and	CCONJ
admet-1022	78	19	scorero5	scorero5	PROPN
admet-1022	78	20	/	/	SYM
admet-1022	78	21	mlogp	mlogp	NOUN
admet-1022	78	22	,	,	PUNCT
admet-1022	78	23	respectively	respectively	ADV
admet-1022	78	24	.	.	PUNCT
admet-1022	79	1	calculations	calculation	NOUN
admet-1022	79	2	of	of	ADP
admet-1022	79	3	ro5	ro5	ADJ
admet-1022	79	4	scores	score	NOUN
admet-1022	79	5	have	have	AUX
admet-1022	79	6	been	be	AUX
admet-1022	79	7	performed	perform	VERB
admet-1022	79	8	manually	manually	ADV
admet-1022	79	9	for	for	ADP
admet-1022	79	10	the	the	DET
admet-1022	79	11	first	first	ADJ
admet-1022	79	12	two	two	NUM
admet-1022	79	13	,	,	PUNCT
admet-1022	79	14	while	while	SCONJ
admet-1022	79	15	medchem	medchem	NOUN
admet-1022	79	16	designer	designer	NOUN
admet-1022	79	17	has	have	AUX
admet-1022	79	18	provided	provide	VERB
admet-1022	79	19	scorero5	scorero5	PROPN
admet-1022	79	20	/	/	SYM
admet-1022	79	21	mlogp	mlogp	NOUN
admet-1022	79	22	.	.	PUNCT
admet-1022	80	1	fli	fli	ADJ
admet-1022	80	2	values	value	NOUN
admet-1022	80	3	were	be	AUX
admet-1022	80	4	calculated	calculate	VERB
admet-1022	80	5	according	accord	VERB
admet-1022	80	6	to	to	ADP
admet-1022	80	7	eq	eq	NOUN
admet-1022	80	8	.	.	PROPN
admet-1022	80	9	2	2	NUM
admet-1022	80	10	for	for	ADP
admet-1022	80	11	ph=7.4	ph=7.4	NOUN
admet-1022	80	12	for	for	ADP
admet-1022	80	13	bases	basis	NOUN
admet-1022	80	14	and	and	CCONJ
admet-1022	80	15	ph=5.5	ph=5.5	NOUN
admet-1022	80	16	for	for	ADP
admet-1022	80	17	acids	acid	NOUN
admet-1022	80	18	.	.	PUNCT
admet-1022	81	1	fli	fli	ADJ
admet-1022	81	2	values	value	NOUN
admet-1022	81	3	of	of	ADP
admet-1022	81	4	zwitterions	zwitterion	NOUN
admet-1022	81	5	were	be	AUX
admet-1022	81	6	calculated	calculate	VERB
admet-1022	81	7	either	either	CCONJ
admet-1022	81	8	at	at	ADP
admet-1022	81	9	ph	ph	PROPN
admet-1022	81	10	7.4	7.4	NUM
admet-1022	81	11	or	or	CCONJ
admet-1022	81	12	at	at	ADP
admet-1022	81	13	ph	ph	ADJ
admet-1022	81	14	5.5	5.5	NUM
admet-1022	81	15	according	accord	VERB
admet-1022	81	16	to	to	ADP
admet-1022	81	17	their	their	PRON
admet-1022	81	18	isoelectric	isoelectric	ADJ
admet-1022	81	19	point	point	NOUN
admet-1022	81	20	.	.	PUNCT
admet-1022	82	1	fli	fli	PROPN
admet-1022	82	2	-	-	PUNCT
admet-1022	82	3	c	c	PROPN
admet-1022	82	4	and	and	CCONJ
admet-1022	82	5	fli	fli	NOUN
admet-1022	82	6	-	-	NOUN
admet-1022	82	7	m	m	PROPN
admet-1022	82	8	were	be	AUX
admet-1022	82	9	calculated	calculate	VERB
admet-1022	82	10	using	use	VERB
admet-1022	82	11	the	the	DET
admet-1022	82	12	corresponding	correspond	VERB
admet-1022	82	13	clogp	clogp	ADJ
admet-1022	82	14	/	/	SYM
admet-1022	82	15	clogd	clogd	ADJ
admet-1022	82	16	and	and	CCONJ
admet-1022	82	17	mlogp	mlogp	NOUN
admet-1022	82	18	/	/	SYM
admet-1022	82	19	mlogd	mlogd	ADJ
admet-1022	82	20	values	value	NOUN
admet-1022	82	21	.	.	PUNCT
admet-1022	83	1	fli	fli	NOUN
admet-1022	83	2	,	,	PUNCT
admet-1022	83	3	fli	fli	NOUN
admet-1022	83	4	-	-	PUNCT
admet-1022	83	5	c	c	NOUN
admet-1022	83	6	and	and	CCONJ
admet-1022	83	7	fli	fli	NOUN
admet-1022	83	8	-	-	NOUN
admet-1022	83	9	m	m	NOUN
admet-1022	83	10	are	be	AUX
admet-1022	83	11	included	include	VERB
admet-1022	83	12	in	in	ADP
admet-1022	83	13	table	table	NOUN
admet-1022	83	14	1s	1s	NUM
admet-1022	83	15	,	,	PUNCT
admet-1022	83	16	supplementary	supplementary	ADJ
admet-1022	83	17	material	material	NOUN
admet-1022	83	18	.	.	PUNCT
admet-1022	84	1	statistical	statistical	ADJ
admet-1022	84	2	analysis	analysis	NOUN
admet-1022	84	3	the	the	DET
admet-1022	84	4	program	program	NOUN
admet-1022	84	5	statistica	statistica	NOUN
admet-1022	84	6	7.1	7.1	NUM
admet-1022	84	7	,	,	PUNCT
admet-1022	84	8	copyright	copyright	PROPN
admet-1022	84	9	©	©	PROPN
admet-1022	84	10	statsoft	statsoft	PROPN
admet-1022	84	11	inc	inc	PROPN
admet-1022	84	12	.	.	PROPN
admet-1022	84	13	1984	1984	NUM
admet-1022	84	14	-	-	SYM
admet-1022	84	15	2006	2006	NUM
admet-1022	84	16	,	,	PUNCT
admet-1022	84	17	2300	2300	NUM
admet-1022	84	18	east	east	PROPN
admet-1022	84	19	14th	14th	PROPN
admet-1022	84	20	street	street	NOUN
admet-1022	84	21	,	,	PUNCT
admet-1022	84	22	tulsa	tulsa	PROPN
admet-1022	84	23	,	,	PUNCT
admet-1022	84	24	ok	ok	PROPN
admet-1022	84	25	74104	74104	NUM
admet-1022	84	26	,	,	PUNCT
admet-1022	84	27	usa	usa	PROPN
admet-1022	84	28	was	be	AUX
admet-1022	84	29	used	use	VERB
admet-1022	84	30	for	for	ADP
admet-1022	84	31	statistical	statistical	ADJ
admet-1022	84	32	analysis	analysis	NOUN
admet-1022	84	33	and	and	CCONJ
admet-1022	84	34	histograms	histogram	NOUN
admet-1022	84	35	’	'	PUNCT
admet-1022	84	36	construction	construction	NOUN
admet-1022	84	37	.	.	PUNCT
admet-1022	85	1	results	result	NOUN
admet-1022	85	2	and	and	CCONJ
admet-1022	85	3	discussion	discussion	NOUN
admet-1022	85	4	data	datum	NOUN
admet-1022	85	5	overview	overview	VERB
admet-1022	85	6	the	the	DET
admet-1022	85	7	property	property	NOUN
admet-1022	85	8	overview	overview	NOUN
admet-1022	85	9	of	of	ADP
admet-1022	85	10	the	the	DET
admet-1022	85	11	drugs	drug	NOUN
admet-1022	85	12	considered	consider	VERB
admet-1022	85	13	in	in	ADP
admet-1022	85	14	the	the	DET
admet-1022	85	15	present	present	ADJ
admet-1022	85	16	study	study	NOUN
admet-1022	85	17	is	be	AUX
admet-1022	85	18	shown	show	VERB
admet-1022	85	19	in	in	ADP
admet-1022	85	20	table	table	NOUN
admet-1022	85	21	1	1	NUM
admet-1022	85	22	(	(	PUNCT
admet-1022	85	23	supplementary	supplementary	ADJ
admet-1022	85	24	tables	table	NOUN
admet-1022	85	25	)	)	PUNCT
admet-1022	85	26	.	.	PUNCT
admet-1022	86	1	mean	mean	VERB
admet-1022	86	2	logps+	logps+	PROPN
admet-1022	86	3	,	,	PUNCT
admet-1022	86	4	clogp	clogp	ADJ
admet-1022	86	5	and	and	CCONJ
admet-1022	86	6	mlogp	mlogp	ADJ
admet-1022	86	7	values	value	NOUN
admet-1022	86	8	are	be	AUX
admet-1022	86	9	2.63	2.63	NUM
admet-1022	86	10	,	,	PUNCT
admet-1022	86	11	2.68	2.68	NUM
admet-1022	86	12	and	and	CCONJ
admet-1022	86	13	2.02	2.02	NUM
admet-1022	86	14	,	,	PUNCT
admet-1022	86	15	respectively	respectively	ADV
admet-1022	86	16	,	,	PUNCT
admet-1022	86	17	while	while	SCONJ
admet-1022	86	18	mean	mean	VERB
admet-1022	86	19	mw	mw	X
admet-1022	86	20	is	be	AUX
admet-1022	86	21	372.5	372.5	NUM
admet-1022	86	22	.	.	PUNCT
admet-1022	87	1	clear	clear	ADJ
admet-1022	87	2	differentiation	differentiation	NOUN
admet-1022	87	3	in	in	ADP
admet-1022	87	4	the	the	DET
admet-1022	87	5	mean	mean	ADJ
admet-1022	87	6	values	value	NOUN
admet-1022	87	7	is	be	AUX
admet-1022	87	8	observed	observe	VERB
admet-1022	87	9	between	between	ADP
admet-1022	87	10	class	class	NOUN
admet-1022	87	11	1	1	NUM
admet-1022	87	12	and	and	CCONJ
admet-1022	87	13	2	2	NUM
admet-1022	87	14	drugs	drug	NOUN
admet-1022	87	15	.	.	PUNCT
admet-1022	88	1	class	class	NOUN
admet-1022	88	2	1	1	NUM
admet-1022	88	3	drugs	drug	NOUN
admet-1022	88	4	display	display	VERB
admet-1022	88	5	higher	high	ADJ
admet-1022	88	6	mean	mean	NOUN
admet-1022	88	7	lipophilicity	lipophilicity	NOUN
admet-1022	88	8	and	and	CCONJ
admet-1022	88	9	lower	low	ADJ
admet-1022	88	10	mean	mean	ADJ
admet-1022	88	11	mw	mw	NOUN
admet-1022	88	12	,	,	PUNCT
admet-1022	88	13	while	while	SCONJ
admet-1022	88	14	the	the	DET
admet-1022	88	15	opposite	opposite	NOUN
admet-1022	88	16	is	be	AUX
admet-1022	88	17	found	find	VERB
admet-1022	88	18	for	for	ADP
admet-1022	88	19	class	class	NOUN
admet-1022	88	20	2	2	NUM
admet-1022	88	21	.	.	PUNCT
admet-1022	89	1	moreover	moreover	ADV
admet-1022	89	2	,	,	PUNCT
admet-1022	89	3	class	class	NOUN
admet-1022	89	4	2	2	NUM
admet-1022	89	5	drugs	drug	NOUN
admet-1022	89	6	possess	possess	VERB
admet-1022	89	7	a	a	DET
admet-1022	89	8	considerably	considerably	ADV
admet-1022	89	9	higher	high	ADJ
admet-1022	89	10	number	number	NOUN
admet-1022	89	11	of	of	ADP
admet-1022	89	12	hydrogen	hydrogen	NOUN
admet-1022	89	13	bond	bond	NOUN
admet-1022	89	14	donor	donor	NOUN
admet-1022	89	15	(	(	PUNCT
admet-1022	89	16	hd	hd	NOUN
admet-1022	89	17	)	)	PUNCT
admet-1022	89	18	and	and	CCONJ
admet-1022	89	19	acceptor	acceptor	NOUN
admet-1022	89	20	sites	site	NOUN
admet-1022	89	21	(	(	PUNCT
admet-1022	89	22	[	[	X
admet-1022	89	23	n+o	n+o	NUM
admet-1022	89	24	]	]	X
admet-1022	89	25	)	)	PUNCT
admet-1022	89	26	.	.	PUNCT
admet-1022	90	1	for	for	ADP
admet-1022	90	2	class	class	NOUN
admet-1022	90	3	1	1	NUM
admet-1022	90	4	drugs	drug	NOUN
admet-1022	90	5	,	,	PUNCT
admet-1022	90	6	high	high	ADJ
admet-1022	90	7	mw	mw	X
admet-1022	90	8	is	be	AUX
admet-1022	90	9	associated	associate	VERB
admet-1022	90	10	with	with	ADP
admet-1022	90	11	polar	polar	ADJ
admet-1022	90	12	atoms	atom	NOUN
admet-1022	90	13	[	[	X
admet-1022	90	14	n	n	NOUN
admet-1022	90	15	+	+	X
admet-1022	90	16	o	o	X
admet-1022	90	17	]	]	X
admet-1022	90	18	up	up	ADP
admet-1022	90	19	to	to	ADP
admet-1022	90	20	15	15	NUM
admet-1022	90	21	,	,	PUNCT
admet-1022	90	22	while	while	SCONJ
admet-1022	90	23	in	in	ADP
admet-1022	90	24	class	class	NOUN
admet-1022	90	25	2	2	NUM
admet-1022	90	26	,	,	PUNCT
admet-1022	90	27	large	large	ADJ
admet-1022	90	28	molecules	molecule	NOUN
admet-1022	90	29	possess	possess	VERB
admet-1022	90	30	up	up	ADP
admet-1022	90	31	to	to	PART
admet-1022	90	32	33	33	NUM
admet-1022	90	33	polar	polar	ADJ
admet-1022	90	34	atoms	atom	NOUN
admet-1022	90	35	and	and	CCONJ
admet-1022	90	36	lower	low	ADJ
admet-1022	90	37	log	log	NOUN
admet-1022	90	38	p	p	NOUN
admet-1022	90	39	values	value	NOUN
admet-1022	90	40	.	.	PUNCT
admet-1022	91	1	it	it	PRON
admet-1022	91	2	should	should	AUX
admet-1022	91	3	be	be	AUX
admet-1022	91	4	noted	note	VERB
admet-1022	91	5	that	that	SCONJ
admet-1022	91	6	mean	mean	INTJ
admet-1022	91	7	log	log	VERB
admet-1022	91	8	p	p	NOUN
admet-1022	91	9	and	and	CCONJ
admet-1022	91	10	mw	mw	ADJ
admet-1022	91	11	values	value	NOUN
admet-1022	91	12	for	for	ADP
admet-1022	91	13	class	class	NOUN
admet-1022	91	14	1	1	NUM
admet-1022	91	15	are	be	AUX
admet-1022	91	16	considerably	considerably	ADV
admet-1022	91	17	higher	high	ADJ
admet-1022	91	18	than	than	ADP
admet-1022	91	19	those	those	PRON
admet-1022	91	20	reported	report	VERB
admet-1022	91	21	for	for	ADP
admet-1022	91	22	1791	1791	NUM
admet-1022	91	23	oral	oral	ADJ
admet-1022	91	24	drugs	drug	NOUN
admet-1022	91	25	of	of	ADP
admet-1022	91	26	the	the	DET
admet-1022	91	27	chembl	chembl	NOUN
admet-1022	91	28	database	database	NOUN
admet-1022	91	29	-including	-include	VERB
admet-1022	91	30	both	both	CCONJ
admet-1022	91	31	neutral	neutral	ADJ
admet-1022	91	32	and	and	CCONJ
admet-1022	91	33	ionizable	ionizable	ADJ
admet-1022	91	34	molecules	molecule	NOUN
admet-1022	91	35	which	which	PRON
admet-1022	91	36	are	be	AUX
admet-1022	91	37	close	close	ADJ
admet-1022	91	38	to	to	ADP
admet-1022	91	39	2.5	2.5	NUM
admet-1022	91	40	and	and	CCONJ
admet-1022	91	41	333	333	NUM
admet-1022	91	42	,	,	PUNCT
admet-1022	91	43	respectively	respectively	ADV
admet-1022	91	44	[	[	X
admet-1022	91	45	27,28	27,28	NOUN
admet-1022	91	46	]	]	X
admet-1022	91	47	.	.	PUNCT
admet-1022	92	1	as	as	ADV
admet-1022	92	2	also	also	ADV
admet-1022	92	3	commented	comment	VERB
admet-1022	92	4	in	in	ADP
admet-1022	92	5	our	our	PRON
admet-1022	92	6	previous	previous	ADJ
admet-1022	92	7	publication	publication	NOUN
admet-1022	92	8	[	[	X
admet-1022	92	9	24	24	NUM
admet-1022	92	10	]	]	PUNCT
admet-1022	92	11	,	,	PUNCT
admet-1022	92	12	there	there	PRON
admet-1022	92	13	is	be	VERB
admet-1022	92	14	a	a	DET
admet-1022	92	15	shift	shift	NOUN
admet-1022	92	16	towards	towards	ADP
admet-1022	92	17	higher	high	ADJ
admet-1022	92	18	log	log	NOUN
admet-1022	92	19	p	p	NOUN
admet-1022	92	20	and	and	CCONJ
admet-1022	92	21	mw	mw	NOUN
admet-1022	92	22	for	for	ADP
admet-1022	92	23	drugs	drug	NOUN
admet-1022	92	24	approved	approve	VERB
admet-1022	92	25	after	after	ADP
admet-1022	92	26	2000	2000	NUM
admet-1022	92	27	,	,	PUNCT
admet-1022	92	28	which	which	PRON
admet-1022	92	29	display	display	NOUN
admet-1022	92	30	mean	mean	VERB
admet-1022	92	31	logps+/clogp	logps+/clogp	NOUN
admet-1022	92	32	and	and	CCONJ
admet-1022	92	33	mw	mw	ADJ
admet-1022	92	34	values	value	NOUN
admet-1022	92	35	3.34/3.42	3.34/3.42	NUM
admet-1022	92	36	and	and	CCONJ
admet-1022	92	37	430.9	430.9	NUM
admet-1022	92	38	respectively	respectively	ADV
admet-1022	92	39	.	.	PUNCT
admet-1022	93	1	in	in	ADP
admet-1022	93	2	particular	particular	ADJ
admet-1022	93	3	,	,	PUNCT
admet-1022	93	4	for	for	ADP
admet-1022	93	5	drugs	drug	NOUN
admet-1022	93	6	approved	approve	VERB
admet-1022	93	7	between	between	ADP
admet-1022	93	8	2000	2000	NUM
admet-1022	93	9	-	-	SYM
admet-1022	93	10	2009	2009	NUM
admet-1022	93	11	mean	mean	NOUN
admet-1022	93	12	logps+/clogp	logps+/clogp	NOUN
admet-1022	93	13	/	/	SYM
admet-1022	93	14	mlogp	mlogp	NOUN
admet-1022	93	15	and	and	CCONJ
admet-1022	93	16	mw	mw	PROPN
admet-1022	93	17	are	be	AUX
admet-1022	93	18	3.39/3.38/2.71	3.39/3.38/2.71	NUM
admet-1022	93	19	and	and	CCONJ
admet-1022	93	20	365.1	365.1	NUM
admet-1022	93	21	,	,	PUNCT
admet-1022	93	22	respectively	respectively	ADV
admet-1022	93	23	,	,	PUNCT
admet-1022	93	24	while	while	SCONJ
admet-1022	93	25	a	a	DET
admet-1022	93	26	further	further	ADJ
admet-1022	93	27	increase	increase	NOUN
admet-1022	93	28	in	in	ADP
admet-1022	93	29	mean	mean	NOUN
admet-1022	93	30	mw	mw	VERB
admet-1022	93	31	to	to	ADP
admet-1022	93	32	465.1	465.1	NUM
admet-1022	93	33	is	be	AUX
admet-1022	93	34	observed	observe	VERB
admet-1022	93	35	for	for	ADP
admet-1022	93	36	drugs	drug	NOUN
admet-1022	93	37	approved	approve	VERB
admet-1022	93	38	in	in	ADP
admet-1022	93	39	the	the	DET
admet-1022	93	40	last	last	ADJ
admet-1022	93	41	decade	decade	NOUN
admet-1022	93	42	(	(	PUNCT
admet-1022	93	43	2010	2010	NUM
admet-1022	93	44	-	-	SYM
admet-1022	93	45	2020	2020	NUM
admet-1022	93	46	)	)	PUNCT
admet-1022	93	47	.	.	PUNCT
admet-1022	94	1	for	for	ADP
admet-1022	94	2	drugs	drug	NOUN
admet-1022	94	3	before	before	ADP
admet-1022	94	4	2000	2000	NUM
admet-1022	94	5	,	,	PUNCT
admet-1022	94	6	descriptive	descriptive	ADJ
admet-1022	94	7	statistics	statistic	NOUN
admet-1022	94	8	show	show	VERB
admet-1022	94	9	mean	mean	VERB
admet-1022	94	10	logps+	logps+	ADP
admet-1022	94	11	clogp	clogp	NOUN
admet-1022	94	12	and	and	CCONJ
admet-1022	94	13	mlogp	mlogp	NOUN
admet-1022	94	14	2.40	2.40	NUM
admet-1022	94	15	,	,	PUNCT
admet-1022	94	16	2.44	2.44	NUM
admet-1022	94	17	and	and	CCONJ
admet-1022	94	18	1.88	1.88	NUM
admet-1022	94	19	respectively	respectively	ADV
admet-1022	94	20	and	and	CCONJ
admet-1022	94	21	a	a	DET
admet-1022	94	22	mean	mean	NOUN
admet-1022	94	23	mw	mw	NOUN
admet-1022	94	24	equal	equal	ADJ
admet-1022	94	25	to	to	ADP
admet-1022	94	26	353.5	353.5	NUM
admet-1022	94	27	.	.	PUNCT
admet-1022	95	1	more	more	ADJ
admet-1022	95	2	to	to	ADP
admet-1022	95	3	the	the	DET
admet-1022	95	4	point	point	NOUN
admet-1022	95	5	,	,	PUNCT
admet-1022	95	6	a	a	DET
admet-1022	95	7	tendency	tendency	NOUN
admet-1022	95	8	to	to	PART
admet-1022	95	9	increase	increase	VERB
admet-1022	95	10	the	the	DET
admet-1022	95	11	number	number	NOUN
admet-1022	95	12	of	of	ADP
admet-1022	95	13	polar	polar	ADJ
admet-1022	95	14	atoms	atom	NOUN
admet-1022	95	15	is	be	AUX
admet-1022	95	16	evident	evident	ADJ
admet-1022	95	17	after	after	ADP
admet-1022	95	18	2000	2000	NUM
admet-1022	95	19	(	(	PUNCT
admet-1022	95	20	table	table	NOUN
admet-1022	95	21	1	1	NUM
admet-1022	95	22	,	,	PUNCT
admet-1022	95	23	supplementary	supplementary	ADJ
admet-1022	95	24	tables	table	NOUN
admet-1022	95	25	)	)	PUNCT
admet-1022	95	26	.	.	PUNCT
admet-1022	96	1	analogous	analogous	ADJ
admet-1022	96	2	findings	finding	NOUN
admet-1022	96	3	are	be	AUX
admet-1022	96	4	reported	report	VERB
admet-1022	96	5	by	by	ADP
admet-1022	96	6	hann	hann	PROPN
admet-1022	96	7	and	and	CCONJ
admet-1022	96	8	keserü	keserü	VERB
admet-1022	97	1	[	[	X
admet-1022	97	2	29	29	NUM
admet-1022	97	3	]	]	PUNCT
admet-1022	97	4	and	and	CCONJ
admet-1022	97	5	shulz	shulz	VERB
admet-1022	98	1	[	[	X
admet-1022	98	2	30	30	NUM
admet-1022	98	3	]	]	PUNCT
admet-1022	98	4	,	,	PUNCT
admet-1022	98	5	who	who	PRON
admet-1022	98	6	outlined	outline	VERB
admet-1022	98	7	property	property	NOUN
admet-1022	98	8	differences	difference	NOUN
admet-1022	98	9	between	between	ADP
admet-1022	98	10	target	target	NOUN
admet-1022	98	11	classes	class	NOUN
admet-1022	98	12	and	and	CCONJ
admet-1022	98	13	companies	company	NOUN
admet-1022	98	14	,	,	PUNCT
admet-1022	98	15	suggesting	suggest	VERB
admet-1022	98	16	apparently	apparently	ADV
admet-1022	98	17	different	different	ADJ
admet-1022	98	18	requirements	requirement	NOUN
admet-1022	98	19	of	of	ADP
admet-1022	98	20	the	the	DET
admet-1022	98	21	expanding	expand	VERB
admet-1022	98	22	target	target	NOUN
admet-1022	98	23	space	space	NOUN
admet-1022	98	24	.	.	PUNCT
admet-1022	99	1	this	this	PRON
admet-1022	99	2	is	be	AUX
admet-1022	99	3	,	,	PUNCT
admet-1022	99	4	for	for	ADP
admet-1022	99	5	instance	instance	NOUN
admet-1022	99	6	,	,	PUNCT
admet-1022	99	7	the	the	DET
admet-1022	99	8	case	case	NOUN
admet-1022	99	9	of	of	ADP
admet-1022	99	10	pparγ	pparγ	ADJ
admet-1022	99	11	agonists	agonist	NOUN
admet-1022	99	12	[	[	X
admet-1022	99	13	31	31	NUM
admet-1022	99	14	]	]	PUNCT
admet-1022	99	15	or	or	CCONJ
admet-1022	99	16	protease	protease	NOUN
admet-1022	99	17	inhibitors	inhibitor	NOUN
admet-1022	99	18	[	[	X
admet-1022	99	19	32	32	NUM
admet-1022	99	20	]	]	PUNCT
admet-1022	99	21	,	,	PUNCT
admet-1022	99	22	indicating	indicate	VERB
admet-1022	99	23	that	that	SCONJ
admet-1022	99	24	drug	drug	NOUN
admet-1022	99	25	-	-	PUNCT
admet-1022	99	26	like	like	ADJ
admet-1022	99	27	properties	property	NOUN
admet-1022	99	28	should	should	AUX
admet-1022	99	29	be	be	AUX
admet-1022	99	30	adapted	adapt	VERB
admet-1022	99	31	over	over	ADP
admet-1022	99	32	time	time	NOUN
admet-1022	99	33	.	.	PUNCT
admet-1022	100	1	admet	admet	PROPN
admet-1022	100	2	&	&	CCONJ
admet-1022	100	3	dmpk	dmpk	PROPN
admet-1022	100	4	9(3	9(3	NUM
admet-1022	100	5	)	)	PUNCT
admet-1022	100	6	(	(	PUNCT
admet-1022	100	7	2021	2021	NUM
admet-1022	100	8	)	)	PUNCT
admet-1022	100	9	177	177	NUM
admet-1022	100	10	-	-	SYM
admet-1022	100	11	190	190	NUM
admet-1022	100	12	drug	drug	NOUN
admet-1022	100	13	-	-	PUNCT
admet-1022	100	14	likeness	likeness	NOUN
admet-1022	100	15	and	and	CCONJ
admet-1022	100	16	fraction	fraction	NOUN
admet-1022	100	17	lipophilicity	lipophilicity	PROPN
admet-1022	100	18	index	index	NOUN
admet-1022	100	19	doi	doi	NOUN
admet-1022	100	20	:	:	PUNCT
admet-1022	100	21	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	100	22	181	181	NUM
admet-1022	100	23	exploring	explore	VERB
admet-1022	100	24	drug	drug	NOUN
admet-1022	100	25	-	-	PUNCT
admet-1022	100	26	like	like	ADJ
admet-1022	100	27	properties	property	NOUN
admet-1022	100	28	inter	inter	NOUN
admet-1022	100	29	-	-	NOUN
admet-1022	100	30	relation	relation	NOUN
admet-1022	100	31	as	as	SCONJ
admet-1022	100	32	aforementioned	aforementione	VERB
admet-1022	100	33	,	,	PUNCT
admet-1022	100	34	log	log	NOUN
admet-1022	100	35	d	d	NOUN
admet-1022	100	36	values	value	NOUN
admet-1022	100	37	per	per	X
admet-1022	100	38	se	se	ADV
admet-1022	100	39	do	do	AUX
admet-1022	100	40	not	not	PART
admet-1022	100	41	give	give	VERB
admet-1022	100	42	information	information	NOUN
admet-1022	100	43	about	about	ADP
admet-1022	100	44	ionization	ionization	NOUN
admet-1022	100	45	if	if	SCONJ
admet-1022	100	46	log	log	PROPN
admet-1022	100	47	p	p	NOUN
admet-1022	100	48	is	be	AUX
admet-1022	100	49	not	not	PART
admet-1022	100	50	considered	consider	VERB
admet-1022	100	51	.	.	PUNCT
admet-1022	101	1	to	to	PART
admet-1022	101	2	explore	explore	VERB
admet-1022	101	3	ionization	ionization	NOUN
admet-1022	101	4	throughout	throughout	ADP
admet-1022	101	5	the	the	DET
admet-1022	101	6	logps+	logps+	PROPN
admet-1022	101	7	range	range	NOUN
admet-1022	101	8	,	,	PUNCT
admet-1022	101	9	the	the	DET
admet-1022	101	10	difference	difference	NOUN
admet-1022	101	11	δ(log	δ(log	NOUN
admet-1022	101	12	p	p	NOUN
admet-1022	101	13	–	–	PUNCT
admet-1022	101	14	log	log	NOUN
admet-1022	101	15	d	d	NOUN
admet-1022	101	16	)	)	PUNCT
admet-1022	101	17	was	be	AUX
admet-1022	101	18	compared	compare	VERB
admet-1022	101	19	to	to	ADP
admet-1022	101	20	two	two	NUM
admet-1022	101	21	logps+	logps+	NOUN
admet-1022	101	22	levels	level	NOUN
admet-1022	101	23	,	,	PUNCT
admet-1022	101	24	above	above	ADV
admet-1022	101	25	and	and	CCONJ
admet-1022	101	26	below	below	ADP
admet-1022	101	27	the	the	DET
admet-1022	101	28	drug	drug	NOUN
admet-1022	101	29	-	-	PUNCT
admet-1022	101	30	like	like	ADJ
admet-1022	101	31	limit	limit	NOUN
admet-1022	101	32	of	of	ADP
admet-1022	101	33	five	five	NUM
admet-1022	101	34	.	.	PUNCT
admet-1022	102	1	it	it	PRON
admet-1022	102	2	was	be	AUX
admet-1022	102	3	found	find	VERB
admet-1022	102	4	that	that	SCONJ
admet-1022	102	5	maximum	maximum	ADJ
admet-1022	102	6	δ(log	δ(log	NOUN
admet-1022	102	7	p	p	NOUN
admet-1022	102	8	–	–	PUNCT
admet-1022	102	9	log	log	NOUN
admet-1022	102	10	d	d	NOUN
admet-1022	102	11	)	)	PUNCT
admet-1022	102	12	,	,	PUNCT
admet-1022	102	13	e.g.	e.g.	ADV
admet-1022	102	14	maximum	maximum	ADJ
admet-1022	102	15	ionization	ionization	NOUN
admet-1022	102	16	,	,	PUNCT
admet-1022	102	17	is	be	AUX
admet-1022	102	18	differentiated	differentiate	VERB
admet-1022	102	19	between	between	ADP
admet-1022	102	20	the	the	DET
admet-1022	102	21	two	two	NUM
admet-1022	102	22	logps+	logps+	NOUN
admet-1022	102	23	levels	level	NOUN
admet-1022	102	24	in	in	ADP
admet-1022	102	25	both	both	DET
admet-1022	102	26	class	class	NOUN
admet-1022	102	27	1	1	NUM
admet-1022	102	28	and	and	CCONJ
admet-1022	102	29	class	class	NOUN
admet-1022	102	30	2	2	NUM
admet-1022	102	31	,	,	PUNCT
admet-1022	102	32	with	with	ADP
admet-1022	102	33	reduced	reduced	ADJ
admet-1022	102	34	ionization	ionization	NOUN
admet-1022	102	35	for	for	ADP
admet-1022	102	36	highly	highly	ADV
admet-1022	102	37	lipophilic	lipophilic	ADJ
admet-1022	102	38	drugs	drug	NOUN
admet-1022	102	39	(	(	PUNCT
admet-1022	102	40	table	table	NOUN
admet-1022	102	41	2	2	NUM
admet-1022	102	42	,	,	PUNCT
admet-1022	102	43	supplementary	supplementary	ADJ
admet-1022	102	44	tables	table	NOUN
admet-1022	102	45	)	)	PUNCT
admet-1022	102	46	.	.	PUNCT
admet-1022	103	1	the	the	DET
admet-1022	103	2	ionization	ionization	NOUN
admet-1022	103	3	pattern	pattern	NOUN
admet-1022	103	4	according	accord	VERB
admet-1022	103	5	to	to	ADP
admet-1022	103	6	logps+	logps+	PROPN
admet-1022	103	7	boundaries	boundary	NOUN
admet-1022	103	8	is	be	AUX
admet-1022	103	9	provided	provide	VERB
admet-1022	103	10	in	in	ADP
admet-1022	103	11	figure	figure	NOUN
admet-1022	103	12	1	1	NUM
admet-1022	103	13	.	.	PUNCT
admet-1022	104	1	the	the	DET
admet-1022	104	2	log	log	NOUN
admet-1022	104	3	p	p	NOUN
admet-1022	104	4	dependent	dependent	ADJ
admet-1022	104	5	ionization	ionization	NOUN
admet-1022	104	6	will	will	AUX
admet-1022	104	7	be	be	AUX
admet-1022	104	8	further	far	ADV
admet-1022	104	9	discussed	discuss	VERB
admet-1022	104	10	in	in	ADP
admet-1022	104	11	relation	relation	NOUN
admet-1022	104	12	to	to	ADP
admet-1022	104	13	the	the	DET
admet-1022	104	14	fli	fli	PROPN
admet-1022	104	15	concept	concept	NOUN
admet-1022	104	16	.	.	PUNCT
admet-1022	105	1	figure	figure	NOUN
admet-1022	105	2	1	1	NUM
admet-1022	105	3	.	.	PUNCT
admet-1022	105	4	ionization	ionization	NOUN
admet-1022	105	5	pattern	pattern	NOUN
admet-1022	105	6	for	for	ADP
admet-1022	105	7	drugs	drug	NOUN
admet-1022	105	8	with	with	ADP
admet-1022	105	9	logps	logps	NOUN
admet-1022	105	10	+	+	CCONJ
admet-1022	105	11	≤5	≤5	X
admet-1022	105	12	(	(	PUNCT
admet-1022	105	13	left	left	ADJ
admet-1022	105	14	)	)	PUNCT
admet-1022	105	15	and	and	CCONJ
admet-1022	105	16	logps	logps	NOUN
admet-1022	106	1	+	+	CCONJ
admet-1022	106	2	>	>	SYM
admet-1022	106	3	5	5	NUM
admet-1022	106	4	(	(	PUNCT
admet-1022	106	5	right	right	ADJ
admet-1022	106	6	)	)	PUNCT
admet-1022	106	7	for	for	ADP
admet-1022	106	8	class	class	NOUN
admet-1022	106	9	1	1	NUM
admet-1022	106	10	drugs	drug	NOUN
admet-1022	106	11	,	,	PUNCT
admet-1022	106	12	ionization	ionization	NOUN
admet-1022	106	13	is	be	AUX
admet-1022	106	14	observed	observe	VERB
admet-1022	106	15	to	to	PART
admet-1022	106	16	be	be	AUX
admet-1022	106	17	also	also	ADV
admet-1022	106	18	size	size	NOUN
admet-1022	106	19	-	-	PUNCT
admet-1022	106	20	dependent	dependent	ADJ
admet-1022	106	21	.	.	PUNCT
admet-1022	107	1	setting	set	VERB
admet-1022	107	2	a	a	DET
admet-1022	107	3	discriminant	discriminant	NOUN
admet-1022	107	4	at	at	ADP
admet-1022	107	5	mw=600	mw=600	ADJ
admet-1022	107	6	reduced	reduced	ADJ
admet-1022	107	7	ionization	ionization	NOUN
admet-1022	107	8	is	be	AUX
admet-1022	107	9	observed	observe	VERB
admet-1022	107	10	for	for	ADP
admet-1022	107	11	drugs	drug	NOUN
admet-1022	107	12	with	with	ADP
admet-1022	107	13	mw>600	mw>600	NUM
admet-1022	107	14	with	with	ADP
admet-1022	107	15	maximum	maximum	ADJ
admet-1022	107	16	δ(log	δ(log	NOUN
admet-1022	107	17	p	p	NOUN
admet-1022	107	18	–	–	PUNCT
admet-1022	107	19	log	log	NOUN
admet-1022	107	20	d	d	NOUN
admet-1022	107	21	)	)	PUNCT
admet-1022	107	22	equal	equal	ADJ
admet-1022	107	23	to	to	ADP
admet-1022	107	24	1.75	1.75	NUM
admet-1022	107	25	,	,	PUNCT
admet-1022	107	26	while	while	SCONJ
admet-1022	107	27	for	for	ADP
admet-1022	107	28	drugs	drug	NOUN
admet-1022	107	29	with	with	ADP
admet-1022	107	30	mw<600	mw<600	NOUN
admet-1022	107	31	,	,	PUNCT
admet-1022	107	32	maximum	maximum	ADJ
admet-1022	107	33	δ(log	δ(log	NOUN
admet-1022	107	34	p	p	NOUN
admet-1022	107	35	–	–	PUNCT
admet-1022	107	36	log	log	NOUN
admet-1022	107	37	d	d	NOUN
admet-1022	107	38	)	)	PUNCT
admet-1022	107	39	is	be	AUX
admet-1022	107	40	3.49	3.49	NUM
admet-1022	107	41	.	.	PUNCT
admet-1022	108	1	the	the	DET
admet-1022	108	2	analogous	analogous	ADJ
admet-1022	108	3	situation	situation	NOUN
admet-1022	108	4	is	be	AUX
admet-1022	108	5	observed	observe	VERB
admet-1022	108	6	for	for	ADP
admet-1022	108	7	class	class	NOUN
admet-1022	108	8	2	2	NUM
admet-1022	108	9	drugs	drug	NOUN
admet-1022	108	10	,	,	PUNCT
admet-1022	108	11	although	although	SCONJ
admet-1022	108	12	higher	high	ADJ
admet-1022	108	13	ionization	ionization	NOUN
admet-1022	108	14	is	be	AUX
admet-1022	108	15	generally	generally	ADV
admet-1022	108	16	observed	observe	VERB
admet-1022	108	17	with	with	ADP
admet-1022	108	18	maximum	maximum	ADJ
admet-1022	108	19	δ(log	δ(log	NOUN
admet-1022	108	20	p	p	NOUN
admet-1022	108	21	–	–	PUNCT
admet-1022	108	22	log	log	NOUN
admet-1022	108	23	d	d	NOUN
admet-1022	108	24	)	)	PUNCT
admet-1022	108	25	values	value	NOUN
admet-1022	108	26	2.31	2.31	NUM
admet-1022	108	27	and	and	CCONJ
admet-1022	108	28	4.89	4.89	NUM
admet-1022	108	29	for	for	ADP
admet-1022	108	30	mw>600	mw>600	NUM
admet-1022	108	31	and	and	CCONJ
admet-1022	108	32	mw<600	mw<600	NOUN
admet-1022	108	33	,	,	PUNCT
admet-1022	108	34	respectively	respectively	ADV
admet-1022	108	35	(	(	PUNCT
admet-1022	108	36	table	table	NOUN
admet-1022	108	37	2	2	NUM
admet-1022	108	38	,	,	PUNCT
admet-1022	108	39	supplementary	supplementary	ADJ
admet-1022	108	40	tables	table	NOUN
admet-1022	108	41	)	)	PUNCT
admet-1022	108	42	.	.	PUNCT
admet-1022	109	1	figure	figure	NOUN
admet-1022	109	2	2	2	NUM
admet-1022	109	3	shows	show	VERB
admet-1022	109	4	the	the	DET
admet-1022	109	5	different	different	ADJ
admet-1022	109	6	ionization	ionization	NOUN
admet-1022	109	7	levels	level	NOUN
admet-1022	109	8	according	accord	VERB
admet-1022	109	9	to	to	ADP
admet-1022	109	10	mw	mw	NOUN
admet-1022	109	11	for	for	ADP
admet-1022	109	12	class	class	NOUN
admet-1022	109	13	1	1	NUM
admet-1022	109	14	and	and	CCONJ
admet-1022	109	15	class	class	NOUN
admet-1022	109	16	2	2	NUM
admet-1022	109	17	separately	separately	ADV
admet-1022	109	18	.	.	PUNCT
admet-1022	110	1	figure	figure	NOUN
admet-1022	110	2	2	2	NUM
admet-1022	110	3	.	.	PUNCT
admet-1022	110	4	mw	mw	VERB
admet-1022	110	5	dependent	dependent	ADJ
admet-1022	110	6	ionization	ionization	NOUN
admet-1022	110	7	levels	level	NOUN
admet-1022	110	8	for	for	ADP
admet-1022	110	9	class	class	NOUN
admet-1022	110	10	1	1	NUM
admet-1022	110	11	and	and	CCONJ
admet-1022	110	12	class	class	NOUN
admet-1022	110	13	2	2	NUM
admet-1022	110	14	.	.	PUNCT
admet-1022	111	1	(	(	PUNCT
admet-1022	111	2	xaxis	xaxis	PROPN
admet-1022	111	3	is	be	AUX
admet-1022	111	4	in	in	ADP
admet-1022	111	5	different	different	ADJ
admet-1022	111	6	scale	scale	NOUN
admet-1022	111	7	to	to	PART
admet-1022	111	8	avoid	avoid	VERB
admet-1022	111	9	compressing	compress	VERB
admet-1022	111	10	of	of	ADP
admet-1022	111	11	the	the	DET
admet-1022	111	12	histograms	histogram	NOUN
admet-1022	111	13	in	in	ADP
admet-1022	111	14	class	class	NOUN
admet-1022	111	15	1	1	NUM
admet-1022	111	16	,	,	PUNCT
admet-1022	111	17	which	which	PRON
admet-1022	111	18	does	do	AUX
admet-1022	111	19	not	not	PART
admet-1022	111	20	contain	contain	VERB
admet-1022	111	21	drugs	drug	NOUN
admet-1022	111	22	with	with	ADP
admet-1022	111	23	very	very	ADV
admet-1022	111	24	high	high	ADJ
admet-1022	111	25	molecular	molecular	ADJ
admet-1022	111	26	weight	weight	NOUN
admet-1022	111	27	,	,	PUNCT
admet-1022	111	28	as	as	SCONJ
admet-1022	111	29	it	it	PRON
admet-1022	111	30	is	be	AUX
admet-1022	111	31	the	the	DET
admet-1022	111	32	case	case	NOUN
admet-1022	111	33	for	for	ADP
admet-1022	111	34	class	class	NOUN
admet-1022	111	35	2	2	NUM
admet-1022	111	36	drugs	drug	NOUN
admet-1022	111	37	)	)	PUNCT
admet-1022	111	38	.	.	PUNCT
admet-1022	112	1	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	112	2	tsantili	tsantili	NOUN
admet-1022	112	3	-	-	PUNCT
admet-1022	112	4	kakoulidou	kakoulidou	NOUN
admet-1022	112	5	and	and	CCONJ
admet-1022	112	6	demopoulos	demopoulos	PROPN
admet-1022	112	7	admet	admet	PROPN
admet-1022	112	8	&	&	CCONJ
admet-1022	112	9	dmpk	dmpk	PROPN
admet-1022	112	10	9(3	9(3	NUM
admet-1022	112	11	)	)	PUNCT
admet-1022	112	12	(	(	PUNCT
admet-1022	112	13	2021	2021	NUM
admet-1022	112	14	)	)	PUNCT
admet-1022	112	15	177	177	NUM
admet-1022	112	16	-	-	SYM
admet-1022	112	17	190	190	NUM
admet-1022	112	18	182	182	NUM
admet-1022	112	19	regarding	regard	VERB
admet-1022	112	20	log	log	NOUN
admet-1022	112	21	d	d	NOUN
admet-1022	112	22	,	,	PUNCT
admet-1022	112	23	there	there	PRON
admet-1022	112	24	is	be	VERB
admet-1022	112	25	a	a	DET
admet-1022	112	26	tendency	tendency	NOUN
admet-1022	112	27	to	to	PART
admet-1022	112	28	increase	increase	VERB
admet-1022	112	29	with	with	ADP
admet-1022	112	30	mw	mw	NOUN
admet-1022	112	31	.	.	PROPN
admet-1022	112	32	however	however	ADV
admet-1022	112	33	,	,	PUNCT
admet-1022	112	34	this	this	DET
admet-1022	112	35	trend	trend	NOUN
admet-1022	112	36	is	be	AUX
admet-1022	112	37	not	not	PART
admet-1022	112	38	followed	follow	VERB
admet-1022	112	39	for	for	ADP
admet-1022	112	40	drugs	drug	NOUN
admet-1022	112	41	with	with	ADP
admet-1022	112	42	mw>600	mw>600	NUM
admet-1022	112	43	and	and	CCONJ
admet-1022	112	44	very	very	ADV
admet-1022	112	45	hydrophilic	hydrophilic	ADJ
admet-1022	112	46	drugs	drug	NOUN
admet-1022	112	47	(	(	PUNCT
admet-1022	112	48	figure	figure	NOUN
admet-1022	112	49	3a	3a	NUM
admet-1022	112	50	)	)	PUNCT
admet-1022	112	51	.	.	PUNCT
admet-1022	113	1	for	for	ADP
admet-1022	113	2	large	large	ADJ
admet-1022	113	3	molecules	molecule	NOUN
admet-1022	113	4	,	,	PUNCT
admet-1022	113	5	this	this	PRON
admet-1022	113	6	is	be	AUX
admet-1022	113	7	due	due	ADJ
admet-1022	113	8	to	to	ADP
admet-1022	113	9	a	a	DET
admet-1022	113	10	higher	high	ADJ
admet-1022	113	11	number	number	NOUN
admet-1022	113	12	of	of	ADP
admet-1022	113	13	polar	polar	ADJ
admet-1022	113	14	atoms	atom	NOUN
admet-1022	113	15	[	[	X
admet-1022	113	16	n	n	NOUN
admet-1022	113	17	+	+	X
admet-1022	113	18	o	o	NOUN
admet-1022	113	19	]	]	X
admet-1022	113	20	,	,	PUNCT
admet-1022	113	21	which	which	PRON
admet-1022	113	22	contribute	contribute	VERB
admet-1022	113	23	negatively	negatively	ADV
admet-1022	113	24	to	to	PART
admet-1022	113	25	log	log	VERB
admet-1022	113	26	p	p	NOUN
admet-1022	113	27	and	and	CCONJ
admet-1022	113	28	,	,	PUNCT
admet-1022	113	29	thereupon	thereupon	ADV
admet-1022	113	30	to	to	PART
admet-1022	113	31	log	log	VERB
admet-1022	113	32	d	d	NOUN
admet-1022	113	33	values	value	NOUN
admet-1022	113	34	(	(	PUNCT
admet-1022	113	35	figure	figure	NOUN
admet-1022	113	36	3b	3b	NUM
admet-1022	113	37	)	)	PUNCT
admet-1022	113	38	.	.	PUNCT
admet-1022	114	1	in	in	ADP
admet-1022	114	2	particular	particular	ADJ
admet-1022	114	3	,	,	PUNCT
admet-1022	114	4	for	for	ADP
admet-1022	114	5	class	class	NOUN
admet-1022	114	6	2	2	NUM
admet-1022	114	7	drugs	drug	NOUN
admet-1022	114	8	,	,	PUNCT
admet-1022	114	9	there	there	PRON
admet-1022	114	10	is	be	VERB
admet-1022	114	11	a	a	DET
admet-1022	114	12	correlation	correlation	NOUN
admet-1022	114	13	with	with	ADP
admet-1022	114	14	r=0.860	r=0.860	NOUN
admet-1022	114	15	between	between	ADP
admet-1022	114	16	mw	mw	NOUN
admet-1022	114	17	and	and	CCONJ
admet-1022	114	18	the	the	DET
admet-1022	114	19	number	number	NOUN
admet-1022	114	20	of	of	ADP
admet-1022	114	21	polar	polar	ADJ
admet-1022	114	22	atoms	atom	NOUN
admet-1022	114	23	[	[	X
admet-1022	114	24	n+o	n+o	NUM
admet-1022	114	25	]	]	X
admet-1022	114	26	(	(	PUNCT
admet-1022	114	27	figure	figure	NOUN
admet-1022	114	28	3c	3c	NUM
admet-1022	114	29	)	)	PUNCT
admet-1022	114	30	.	.	PUNCT
admet-1022	115	1	figure	figure	VERB
admet-1022	115	2	3	3	NUM
admet-1022	115	3	.	.	PUNCT
admet-1022	116	1	a	a	DET
admet-1022	116	2	:	:	PUNCT
admet-1022	116	3	plot	plot	NOUN
admet-1022	116	4	of	of	ADP
admet-1022	116	5	mw	mw	X
admet-1022	116	6	versus	versus	ADP
admet-1022	116	7	logps	logps	NOUN
admet-1022	116	8	+	+	CCONJ
admet-1022	116	9	and	and	CCONJ
admet-1022	116	10	logds	logds	PROPN
admet-1022	116	11	+	+	CCONJ
admet-1022	116	12	for	for	ADP
admet-1022	116	13	the	the	DET
admet-1022	116	14	entire	entire	ADJ
admet-1022	116	15	set	set	NOUN
admet-1022	116	16	.	.	PUNCT
admet-1022	117	1	b	b	X
admet-1022	117	2	,	,	PUNCT
admet-1022	117	3	c	c	NOUN
admet-1022	117	4	:	:	PUNCT
admet-1022	117	5	plot	plot	NOUN
admet-1022	117	6	of	of	ADP
admet-1022	117	7	mw	mw	X
admet-1022	117	8	versus	versus	ADP
admet-1022	117	9	the	the	DET
admet-1022	117	10	number	number	NOUN
admet-1022	117	11	of	of	ADP
admet-1022	117	12	polar	polar	ADJ
admet-1022	117	13	atoms	atom	NOUN
admet-1022	117	14	[	[	X
admet-1022	117	15	n+o	n+o	X
admet-1022	117	16	]	]	X
admet-1022	117	17	for	for	ADP
admet-1022	117	18	the	the	DET
admet-1022	117	19	entire	entire	ADJ
admet-1022	117	20	set	set	NOUN
admet-1022	117	21	and	and	CCONJ
admet-1022	117	22	class	class	NOUN
admet-1022	117	23	2	2	NUM
admet-1022	117	24	drugs	drug	NOUN
admet-1022	117	25	respectively	respectively	ADV
admet-1022	117	26	.	.	PUNCT
admet-1022	118	1	drugs	drug	NOUN
admet-1022	118	2	beyond	beyond	ADP
admet-1022	118	3	the	the	DET
admet-1022	118	4	drug	drug	NOUN
admet-1022	118	5	-	-	PUNCT
admet-1022	118	6	like	like	ADJ
admet-1022	118	7	limits	limit	NOUN
admet-1022	118	8	recently	recently	ADV
admet-1022	118	9	,	,	PUNCT
admet-1022	118	10	there	there	PRON
admet-1022	118	11	has	have	AUX
admet-1022	118	12	been	be	AUX
admet-1022	118	13	an	an	DET
admet-1022	118	14	increased	increase	VERB
admet-1022	118	15	interest	interest	NOUN
admet-1022	118	16	in	in	ADP
admet-1022	118	17	the	the	DET
admet-1022	118	18	development	development	NOUN
admet-1022	118	19	of	of	ADP
admet-1022	118	20	drugs	drug	NOUN
admet-1022	118	21	beyond	beyond	ADP
admet-1022	118	22	the	the	DET
admet-1022	118	23	rule	rule	NOUN
admet-1022	118	24	of	of	ADP
admet-1022	118	25	five	five	NUM
admet-1022	118	26	(	(	PUNCT
admet-1022	118	27	bro5	bro5	PROPN
admet-1022	118	28	)	)	PUNCT
admet-1022	118	29	,	,	PUNCT
admet-1022	118	30	especially	especially	ADV
admet-1022	118	31	in	in	ADP
admet-1022	118	32	the	the	DET
admet-1022	118	33	area	area	NOUN
admet-1022	118	34	of	of	ADP
admet-1022	118	35	oncology	oncology	NOUN
admet-1022	118	36	and	and	CCONJ
admet-1022	118	37	direct	direct	ADJ
admet-1022	118	38	-	-	PUNCT
admet-1022	118	39	acting	act	VERB
admet-1022	118	40	antivirals	antiviral	NOUN
admet-1022	118	41	(	(	PUNCT
admet-1022	118	42	daa	daa	NOUN
admet-1022	118	43	)	)	PUNCT
admet-1022	119	1	[	[	X
admet-1022	119	2	13	13	NUM
admet-1022	119	3	]	]	PUNCT
admet-1022	119	4	.	.	PUNCT
admet-1022	120	1	in	in	ADP
admet-1022	120	2	this	this	DET
admet-1022	120	3	aspect	aspect	NOUN
admet-1022	120	4	we	we	PRON
admet-1022	120	5	explored	explore	VERB
admet-1022	120	6	violations	violation	NOUN
admet-1022	120	7	of	of	ADP
admet-1022	120	8	ro5	ro5	NOUN
admet-1022	120	9	based	base	VERB
admet-1022	120	10	on	on	ADP
admet-1022	120	11	logps+	logps+	PROPN
admet-1022	120	12	(	(	PUNCT
admet-1022	120	13	scorero5	scorero5	PROPN
admet-1022	120	14	/	/	SYM
admet-1022	120	15	logps+	logps+	NOUN
admet-1022	120	16	)	)	PUNCT
admet-1022	120	17	,	,	PUNCT
admet-1022	120	18	clogp	clogp	ADJ
admet-1022	120	19	(	(	PUNCT
admet-1022	120	20	scorero5	scorero5	NOUN
admet-1022	120	21	/	/	SYM
admet-1022	120	22	clogp	clogp	NOUN
admet-1022	120	23	)	)	PUNCT
admet-1022	120	24	and	and	CCONJ
admet-1022	120	25	mlogp	mlogp	PROPN
admet-1022	120	26	(	(	PUNCT
admet-1022	120	27	scorero5	scorero5	PROPN
admet-1022	120	28	/	/	SYM
admet-1022	120	29	mlogp	mlogp	NOUN
admet-1022	120	30	)	)	PUNCT
admet-1022	120	31	classifying	classify	VERB
admet-1022	120	32	drugs	drug	NOUN
admet-1022	120	33	to	to	ADP
admet-1022	120	34	those	those	PRON
admet-1022	120	35	approved	approve	VERB
admet-1022	120	36	after	after	ADP
admet-1022	120	37	or	or	CCONJ
admet-1022	120	38	before	before	ADP
admet-1022	120	39	2000	2000	NUM
admet-1022	120	40	.	.	PUNCT
admet-1022	121	1	as	as	SCONJ
admet-1022	121	2	shown	show	VERB
admet-1022	121	3	in	in	ADP
admet-1022	121	4	figure	figure	NOUN
admet-1022	121	5	4	4	NUM
admet-1022	121	6	,	,	PUNCT
admet-1022	121	7	there	there	PRON
admet-1022	121	8	is	be	VERB
admet-1022	121	9	a	a	DET
admet-1022	121	10	considerable	considerable	ADJ
admet-1022	121	11	increase	increase	NOUN
admet-1022	121	12	in	in	ADP
admet-1022	121	13	the	the	DET
admet-1022	121	14	percentage	percentage	NOUN
admet-1022	121	15	of	of	ADP
admet-1022	121	16	drugs	drug	NOUN
admet-1022	121	17	with	with	ADP
admet-1022	121	18	more	more	ADJ
admet-1022	121	19	than	than	ADP
admet-1022	121	20	two	two	NUM
admet-1022	121	21	violations	violation	NOUN
admet-1022	121	22	after	after	ADP
admet-1022	121	23	2000	2000	NUM
admet-1022	121	24	with	with	ADP
admet-1022	121	25	20	20	NUM
admet-1022	121	26	,	,	PUNCT
admet-1022	121	27	18	18	NUM
admet-1022	121	28	and	and	CCONJ
admet-1022	121	29	14	14	NUM
admet-1022	121	30	%	%	NOUN
admet-1022	121	31	according	accord	VERB
admet-1022	121	32	to	to	ADP
admet-1022	121	33	logps+	logps+	ADP
admet-1022	121	34	,	,	PUNCT
admet-1022	121	35	clogp	clogp	ADJ
admet-1022	121	36	and	and	CCONJ
admet-1022	121	37	mlogp	mlogp	NOUN
admet-1022	121	38	systems	system	NOUN
admet-1022	121	39	,	,	PUNCT
admet-1022	121	40	respectively	respectively	ADV
admet-1022	121	41	,	,	PUNCT
admet-1022	121	42	compared	compare	VERB
admet-1022	121	43	to	to	ADP
admet-1022	121	44	the	the	DET
admet-1022	121	45	corresponding	correspond	VERB
admet-1022	121	46	8	8	NUM
admet-1022	121	47	,	,	PUNCT
admet-1022	121	48	8	8	NUM
admet-1022	121	49	and	and	CCONJ
admet-1022	121	50	7	7	NUM
admet-1022	121	51	%	%	NOUN
admet-1022	121	52	before	before	ADP
admet-1022	121	53	2000	2000	NUM
admet-1022	121	54	(	(	PUNCT
admet-1022	121	55	figure	figure	NOUN
admet-1022	121	56	4	4	NUM
admet-1022	121	57	)	)	PUNCT
admet-1022	121	58	.	.	PUNCT
admet-1022	122	1	if	if	SCONJ
admet-1022	122	2	we	we	PRON
admet-1022	122	3	focus	focus	VERB
admet-1022	122	4	on	on	ADP
admet-1022	122	5	class	class	NOUN
admet-1022	122	6	1	1	NUM
admet-1022	122	7	drugs	drug	NOUN
admet-1022	122	8	approved	approve	VERB
admet-1022	122	9	after	after	ADP
admet-1022	122	10	2000	2000	NUM
admet-1022	122	11	,	,	PUNCT
admet-1022	122	12	the	the	DET
admet-1022	122	13	bro5	bro5	NOUN
admet-1022	122	14	cases	case	NOUN
admet-1022	122	15	are	be	AUX
admet-1022	122	16	16	16	NUM
admet-1022	122	17	,	,	PUNCT
admet-1022	122	18	15	15	NUM
admet-1022	122	19	and	and	CCONJ
admet-1022	122	20	10	10	NUM
admet-1022	122	21	%	%	NOUN
admet-1022	122	22	,	,	PUNCT
admet-1022	122	23	respectively	respectively	ADV
admet-1022	122	24	(	(	PUNCT
admet-1022	122	25	figure	figure	NOUN
admet-1022	122	26	not	not	PART
admet-1022	122	27	shown	show	VERB
admet-1022	122	28	)	)	PUNCT
admet-1022	122	29	.	.	PUNCT
admet-1022	123	1	nevertheless	nevertheless	ADV
admet-1022	123	2	,	,	PUNCT
admet-1022	123	3	there	there	PRON
admet-1022	123	4	is	be	VERB
admet-1022	123	5	still	still	ADV
admet-1022	123	6	a	a	DET
admet-1022	123	7	considerable	considerable	ADJ
admet-1022	123	8	differentiation	differentiation	NOUN
admet-1022	123	9	in	in	ADP
admet-1022	123	10	the	the	DET
admet-1022	123	11	distribution	distribution	NOUN
admet-1022	123	12	of	of	ADP
admet-1022	123	13	ro5	ro5	ADJ
admet-1022	123	14	violations	violation	NOUN
admet-1022	123	15	between	between	ADP
admet-1022	123	16	class	class	NOUN
admet-1022	123	17	1	1	NUM
admet-1022	123	18	and	and	CCONJ
admet-1022	123	19	class	class	NOUN
admet-1022	123	20	2	2	NUM
admet-1022	123	21	drugs	drug	NOUN
admet-1022	123	22	.	.	PUNCT
admet-1022	124	1	for	for	ADP
admet-1022	124	2	class	class	NOUN
admet-1022	124	3	1	1	NUM
admet-1022	124	4	,	,	PUNCT
admet-1022	124	5	82	82	NUM
admet-1022	124	6	,	,	PUNCT
admet-1022	124	7	79	79	NUM
admet-1022	124	8	and	and	CCONJ
admet-1022	124	9	84	84	NUM
admet-1022	124	10	%	%	NOUN
admet-1022	124	11	of	of	ADP
admet-1022	124	12	the	the	DET
admet-1022	124	13	drugs	drug	NOUN
admet-1022	124	14	show	show	VERB
admet-1022	124	15	0	0	NUM
admet-1022	124	16	violations	violation	NOUN
admet-1022	124	17	,	,	PUNCT
admet-1022	124	18	respectively	respectively	ADV
admet-1022	124	19	,	,	PUNCT
admet-1022	124	20	11,15	11,15	NUM
admet-1022	124	21	and	and	CCONJ
admet-1022	124	22	11	11	NUM
admet-1022	124	23	%	%	NOUN
admet-1022	124	24	display	display	VERB
admet-1022	124	25	one	one	NUM
admet-1022	124	26	violation	violation	NOUN
admet-1022	124	27	and	and	CCONJ
admet-1022	124	28	only	only	ADV
admet-1022	124	29	6	6	NUM
admet-1022	124	30	,	,	PUNCT
admet-1022	124	31	5	5	NUM
admet-1022	124	32	and	and	CCONJ
admet-1022	124	33	4	4	NUM
admet-1022	124	34	%	%	NOUN
admet-1022	124	35	have	have	AUX
admet-1022	124	36	higher	high	ADJ
admet-1022	124	37	than	than	ADP
admet-1022	124	38	two	two	NUM
admet-1022	124	39	violations	violation	NOUN
admet-1022	124	40	.	.	PUNCT
admet-1022	125	1	for	for	ADP
admet-1022	125	2	class	class	NOUN
admet-1022	125	3	2	2	NUM
admet-1022	125	4	drugs	drug	NOUN
admet-1022	125	5	,	,	PUNCT
admet-1022	125	6	zero	zero	NUM
admet-1022	125	7	violation	violation	NOUN
admet-1022	125	8	is	be	AUX
admet-1022	125	9	displayed	display	VERB
admet-1022	125	10	for	for	ADP
admet-1022	125	11	48	48	NUM
admet-1022	125	12	,	,	PUNCT
admet-1022	125	13	47	47	NUM
admet-1022	125	14	and	and	CCONJ
admet-1022	125	15	48	48	NUM
admet-1022	125	16	%	%	NOUN
admet-1022	125	17	,	,	PUNCT
admet-1022	125	18	respectively	respectively	ADV
admet-1022	125	19	,	,	PUNCT
admet-1022	125	20	while	while	SCONJ
admet-1022	125	21	33	33	NUM
admet-1022	125	22	,	,	PUNCT
admet-1022	125	23	31	31	NUM
admet-1022	125	24	and	and	CCONJ
admet-1022	125	25	29	29	NUM
admet-1022	125	26	%	%	NOUN
admet-1022	125	27	showed	show	VERB
admet-1022	125	28	higher	high	ADJ
admet-1022	125	29	than	than	ADP
admet-1022	125	30	2	2	NUM
admet-1022	125	31	.	.	PUNCT
admet-1022	126	1	in	in	ADP
admet-1022	126	2	figure	figure	NOUN
admet-1022	126	3	5	5	NUM
admet-1022	126	4	the	the	DET
admet-1022	126	5	distribution	distribution	NOUN
admet-1022	126	6	of	of	ADP
admet-1022	126	7	violations	violation	NOUN
admet-1022	126	8	in	in	ADP
admet-1022	126	9	classes	class	NOUN
admet-1022	126	10	1	1	NUM
admet-1022	126	11	and	and	CCONJ
admet-1022	126	12	2	2	NUM
admet-1022	126	13	are	be	AUX
admet-1022	126	14	displayed	display	VERB
admet-1022	126	15	as	as	ADP
admet-1022	126	16	bars	bar	NOUN
admet-1022	126	17	(	(	PUNCT
admet-1022	126	18	left	left	ADJ
admet-1022	126	19	)	)	PUNCT
admet-1022	126	20	,	,	PUNCT
admet-1022	126	21	and	and	CCONJ
admet-1022	126	22	in	in	ADP
admet-1022	126	23	the	the	DET
admet-1022	126	24	case	case	NOUN
admet-1022	126	25	of	of	ADP
admet-1022	126	26	scorero5	scorero5	PROPN
admet-1022	126	27	/	/	SYM
admet-1022	126	28	logps+	logps+	NOUN
admet-1022	126	29	as	as	ADP
admet-1022	126	30	pies	pie	NOUN
admet-1022	126	31	(	(	PUNCT
admet-1022	126	32	right	right	ADJ
admet-1022	126	33	)	)	PUNCT
admet-1022	126	34	.	.	PUNCT
admet-1022	127	1	admet	admet	PROPN
admet-1022	127	2	&	&	CCONJ
admet-1022	127	3	dmpk	dmpk	PROPN
admet-1022	127	4	9(3	9(3	NUM
admet-1022	127	5	)	)	PUNCT
admet-1022	127	6	(	(	PUNCT
admet-1022	127	7	2021	2021	NUM
admet-1022	127	8	)	)	PUNCT
admet-1022	127	9	177	177	NUM
admet-1022	127	10	-	-	SYM
admet-1022	127	11	190	190	NUM
admet-1022	127	12	drug	drug	NOUN
admet-1022	127	13	-	-	PUNCT
admet-1022	127	14	likeness	likeness	NOUN
admet-1022	127	15	and	and	CCONJ
admet-1022	127	16	fraction	fraction	NOUN
admet-1022	127	17	lipophilicity	lipophilicity	PROPN
admet-1022	127	18	index	index	NOUN
admet-1022	127	19	doi	doi	NOUN
admet-1022	127	20	:	:	PUNCT
admet-1022	127	21	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	127	22	183	183	NUM
admet-1022	127	23	figure	figure	NOUN
admet-1022	127	24	4	4	NUM
admet-1022	127	25	.	.	NOUN
admet-1022	127	26	number	number	NOUN
admet-1022	127	27	of	of	ADP
admet-1022	127	28	polar	polar	ADJ
admet-1022	127	29	atoms	atom	NOUN
admet-1022	127	30	[	[	X
admet-1022	127	31	n+o	n+o	X
admet-1022	127	32	]	]	PUNCT
admet-1022	127	33	according	accord	VERB
admet-1022	127	34	to	to	ADP
admet-1022	127	35	mw	mw	ADJ
admet-1022	127	36	levels	level	NOUN
admet-1022	127	37	for	for	ADP
admet-1022	127	38	class	class	NOUN
admet-1022	127	39	1	1	NUM
admet-1022	127	40	and	and	CCONJ
admet-1022	127	41	class	class	NOUN
admet-1022	127	42	2	2	NUM
admet-1022	127	43	drugs	drug	NOUN
admet-1022	127	44	.	.	PUNCT
admet-1022	128	1	figure	figure	NOUN
admet-1022	128	2	5	5	NUM
admet-1022	128	3	.	.	PUNCT
admet-1022	129	1	distribution	distribution	NOUN
admet-1022	129	2	of	of	ADP
admet-1022	129	3	ro5	ro5	ADJ
admet-1022	129	4	violations	violation	NOUN
admet-1022	129	5	in	in	ADP
admet-1022	129	6	class	class	NOUN
admet-1022	129	7	1	1	NUM
admet-1022	129	8	and	and	CCONJ
admet-1022	129	9	class	class	NOUN
admet-1022	129	10	2	2	NUM
admet-1022	129	11	drugs	drug	NOUN
admet-1022	129	12	based	base	VERB
admet-1022	129	13	on	on	ADP
admet-1022	129	14	logps	logps	NOUN
admet-1022	129	15	+	+	CCONJ
admet-1022	129	16	and	and	CCONJ
admet-1022	129	17	clogp	clogp	ADJ
admet-1022	129	18	.	.	PUNCT
admet-1022	130	1	violations	violation	NOUN
admet-1022	130	2	are	be	AUX
admet-1022	130	3	presented	present	VERB
admet-1022	130	4	in	in	ADP
admet-1022	130	5	detail	detail	NOUN
admet-1022	130	6	and	and	CCONJ
admet-1022	130	7	compared	compare	VERB
admet-1022	130	8	to	to	ADP
admet-1022	130	9	the	the	DET
admet-1022	130	10	corresponding	corresponding	ADJ
admet-1022	130	11	%	%	INTJ
admet-1022	130	12	fa	fa	PROPN
admet-1022	130	13	levels	level	NOUN
admet-1022	130	14	in	in	ADP
admet-1022	130	15	table	table	NOUN
admet-1022	130	16	3	3	NUM
admet-1022	130	17	(	(	PUNCT
admet-1022	130	18	suppl	suppl	PROPN
admet-1022	130	19	.	.	PUNCT
admet-1022	130	20	tables	table	NOUN
admet-1022	130	21	)	)	PUNCT
admet-1022	130	22	,	,	PUNCT
admet-1022	130	23	also	also	ADV
admet-1022	130	24	considering	consider	VERB
admet-1022	130	25	low	low	ADJ
admet-1022	130	26	lipophilicity	lipophilicity	NOUN
admet-1022	130	27	limits	limit	NOUN
admet-1022	130	28	,	,	PUNCT
admet-1022	130	29	namely	namely	ADV
admet-1022	130	30	log	log	VERB
admet-1022	130	31	p	p	NOUN
admet-1022	130	32	≤	≤	NOUN
admet-1022	130	33	-0.4	-0.4	NUM
admet-1022	130	34	,	,	PUNCT
admet-1022	130	35	the	the	DET
admet-1022	130	36	minimum	minimum	ADJ
admet-1022	130	37	value	value	NOUN
admet-1022	130	38	suggested	suggest	VERB
admet-1022	130	39	by	by	ADP
admet-1022	130	40	ghose	ghose	PROPN
admet-1022	130	41	et	et	PROPN
admet-1022	130	42	al	al	PROPN
admet-1022	130	43	.	.	PUNCT
admet-1022	131	1	[	[	X
admet-1022	131	2	17	17	NUM
admet-1022	131	3	]	]	PUNCT
admet-1022	131	4	and	and	CCONJ
admet-1022	131	5	log	log	VERB
admet-1022	131	6	p	p	PROPN
admet-1022	131	7	≤	≤	PROPN
admet-1022	131	8	-1	-1	PUNCT
admet-1022	131	9	,	,	PUNCT
admet-1022	131	10	set	set	VERB
admet-1022	131	11	in	in	ADP
admet-1022	131	12	this	this	DET
admet-1022	131	13	paper	paper	NOUN
admet-1022	131	14	as	as	ADP
admet-1022	131	15	a	a	DET
admet-1022	131	16	more	more	ADV
admet-1022	131	17	determinative	determinative	ADJ
admet-1022	131	18	limit	limit	NOUN
admet-1022	131	19	for	for	ADP
admet-1022	131	20	oral	oral	ADJ
admet-1022	131	21	absorption	absorption	NOUN
admet-1022	131	22	.	.	PUNCT
admet-1022	132	1	47	47	NUM
admet-1022	132	2	drugs	drug	NOUN
admet-1022	132	3	display	display	VERB
admet-1022	132	4	logps+<-0.4	logps+<-0.4	PUNCT
admet-1022	132	5	,	,	PUNCT
admet-1022	132	6	27	27	NUM
admet-1022	132	7	out	out	ADP
admet-1022	132	8	of	of	ADP
admet-1022	132	9	them	they	PRON
admet-1022	132	10	with	with	ADP
admet-1022	132	11	additional	additional	ADJ
admet-1022	132	12	violations	violation	NOUN
admet-1022	132	13	of	of	ADP
admet-1022	132	14	the	the	DET
admet-1022	132	15	ro5	ro5	ADJ
admet-1022	132	16	drug	drug	NOUN
admet-1022	132	17	-	-	PUNCT
admet-1022	132	18	like	like	ADJ
admet-1022	132	19	limits	limit	NOUN
admet-1022	132	20	.	.	PUNCT
admet-1022	133	1	eleven	eleven	NUM
admet-1022	133	2	drugs	drug	NOUN
admet-1022	133	3	(	(	PUNCT
admet-1022	133	4	55	55	NUM
admet-1022	133	5	%	%	NOUN
admet-1022	133	6	)	)	PUNCT
admet-1022	133	7	out	out	ADP
admet-1022	133	8	of	of	ADP
admet-1022	133	9	the	the	DET
admet-1022	133	10	20	20	NUM
admet-1022	133	11	with	with	ADP
admet-1022	133	12	no	no	DET
admet-1022	133	13	other	other	ADJ
admet-1022	133	14	ro5	ro5	ADJ
admet-1022	133	15	violations	violation	NOUN
admet-1022	133	16	and	and	CCONJ
admet-1022	133	17	20	20	NUM
admet-1022	133	18	drugs	drug	NOUN
admet-1022	133	19	with	with	ADP
admet-1022	133	20	additional	additional	ADJ
admet-1022	133	21	ro5	ro5	ADJ
admet-1022	133	22	violations	violation	NOUN
admet-1022	133	23	(	(	PUNCT
admet-1022	133	24	74	74	NUM
admet-1022	133	25	%	%	NOUN
admet-1022	133	26	)	)	PUNCT
admet-1022	133	27	have	have	VERB
admet-1022	133	28	low	low	ADJ
admet-1022	133	29	absorption	absorption	NOUN
admet-1022	133	30	.	.	PUNCT
admet-1022	134	1	if	if	SCONJ
admet-1022	134	2	the	the	DET
admet-1022	134	3	cutoff	cutoff	NOUN
admet-1022	134	4	value	value	NOUN
admet-1022	134	5	is	be	AUX
admet-1022	134	6	set	set	VERB
admet-1022	134	7	to	to	ADP
admet-1022	134	8	logps+	logps+	ADP
admet-1022	134	9	<	<	X
admet-1022	134	10	-1	-1	PROPN
admet-1022	134	11	,	,	PUNCT
admet-1022	134	12	the	the	DET
admet-1022	134	13	percentage	percentage	NOUN
admet-1022	134	14	of	of	ADP
admet-1022	134	15	low	low	ADJ
admet-1022	134	16	%	%	NOUN
admet-1022	134	17	fa	fa	NOUN
admet-1022	134	18	increases	increase	VERB
admet-1022	134	19	to	to	ADP
admet-1022	134	20	66.7	66.7	NUM
admet-1022	134	21	%	%	NOUN
admet-1022	134	22	(	(	PUNCT
admet-1022	134	23	8	8	NUM
admet-1022	134	24	out	out	ADP
admet-1022	134	25	of	of	ADP
admet-1022	134	26	12	12	NUM
admet-1022	134	27	drugs	drug	NOUN
admet-1022	134	28	)	)	PUNCT
admet-1022	134	29	and	and	CCONJ
admet-1022	134	30	82	82	NUM
admet-1022	134	31	%	%	NOUN
admet-1022	134	32	(	(	PUNCT
admet-1022	134	33	14	14	NUM
admet-1022	134	34	out	out	ADP
admet-1022	134	35	of	of	ADP
admet-1022	134	36	17	17	NUM
admet-1022	134	37	)	)	PUNCT
admet-1022	134	38	for	for	ADP
admet-1022	134	39	drugs	drug	NOUN
admet-1022	134	40	without	without	ADP
admet-1022	134	41	additional	additional	ADJ
admet-1022	134	42	ro5	ro5	ADJ
admet-1022	134	43	violations	violation	NOUN
admet-1022	134	44	.	.	PUNCT
admet-1022	135	1	looking	look	VERB
admet-1022	135	2	at	at	ADP
admet-1022	135	3	the	the	DET
admet-1022	135	4	upper	upper	ADJ
admet-1022	135	5	extreme	extreme	NOUN
admet-1022	135	6	,	,	PUNCT
admet-1022	135	7	67	67	NUM
admet-1022	135	8	drugs	drug	NOUN
admet-1022	135	9	have	have	AUX
admet-1022	135	10	logps+>5	logps+>5	VERB
admet-1022	135	11	.	.	PUNCT
admet-1022	136	1	among	among	ADP
admet-1022	136	2	them	they	PRON
admet-1022	136	3	,	,	PUNCT
admet-1022	136	4	only	only	ADV
admet-1022	136	5	eight	eight	NUM
admet-1022	136	6	drugs	drug	NOUN
admet-1022	136	7	(	(	PUNCT
admet-1022	136	8	12	12	NUM
admet-1022	136	9	%	%	NOUN
admet-1022	136	10	)	)	PUNCT
admet-1022	136	11	have	have	VERB
admet-1022	136	12	low	low	ADJ
admet-1022	136	13	%	%	NOUN
admet-1022	136	14	fa	fa	NOUN
admet-1022	136	15	.	.	PUNCT
admet-1022	137	1	considering	consider	VERB
admet-1022	137	2	the	the	DET
admet-1022	137	3	total	total	ADJ
admet-1022	137	4	population	population	NOUN
admet-1022	137	5	of	of	ADP
admet-1022	137	6	class	class	NOUN
admet-1022	137	7	2	2	NUM
admet-1022	137	8	,	,	PUNCT
admet-1022	137	9	33	33	NUM
admet-1022	137	10	drugs	drug	NOUN
admet-1022	137	11	(	(	PUNCT
admet-1022	137	12	28	28	NUM
admet-1022	137	13	%	%	NOUN
admet-1022	137	14	)	)	PUNCT
admet-1022	137	15	are	be	AUX
admet-1022	137	16	more	more	ADV
admet-1022	137	17	hydrophilic	hydrophilic	ADJ
admet-1022	137	18	(	(	PUNCT
admet-1022	137	19	logps+<-0.4	logps+<-0.4	ADJ
admet-1022	137	20	)	)	PUNCT
admet-1022	137	21	,	,	PUNCT
admet-1022	137	22	while	while	SCONJ
admet-1022	137	23	only	only	ADV
admet-1022	137	24	8	8	NUM
admet-1022	137	25	(	(	PUNCT
admet-1022	137	26	6.9	6.9	NUM
admet-1022	137	27	%	%	NOUN
admet-1022	137	28	)	)	PUNCT
admet-1022	137	29	exceed	exceed	VERB
admet-1022	137	30	the	the	DET
admet-1022	137	31	ro5	ro5	ADJ
admet-1022	137	32	log	log	NOUN
admet-1022	137	33	p	p	NOUN
admet-1022	137	34	limit	limit	NOUN
admet-1022	137	35	,	,	PUNCT
admet-1022	137	36	indicating	indicate	VERB
admet-1022	137	37	that	that	SCONJ
admet-1022	137	38	high	high	ADJ
admet-1022	137	39	lipophilicity	lipophilicity	NOUN
admet-1022	137	40	is	be	AUX
admet-1022	137	41	rather	rather	ADV
admet-1022	137	42	overrated	overrate	VERB
admet-1022	137	43	as	as	ADP
admet-1022	137	44	an	an	DET
admet-1022	137	45	issue	issue	NOUN
admet-1022	137	46	for	for	ADP
admet-1022	137	47	oral	oral	ADJ
admet-1022	137	48	absorption	absorption	NOUN
admet-1022	137	49	.	.	PUNCT
admet-1022	138	1	regarding	regard	VERB
admet-1022	138	2	molecular	molecular	ADJ
admet-1022	138	3	weight	weight	NOUN
admet-1022	138	4	,	,	PUNCT
admet-1022	138	5	80	80	NUM
admet-1022	138	6	drugs	drug	NOUN
admet-1022	138	7	exceed	exceed	VERB
admet-1022	138	8	the	the	DET
admet-1022	138	9	limit	limit	NOUN
admet-1022	138	10	value	value	NOUN
admet-1022	138	11	of	of	ADP
admet-1022	138	12	500	500	NUM
admet-1022	138	13	,	,	PUNCT
admet-1022	138	14	39	39	NUM
admet-1022	138	15	out	out	ADP
admet-1022	138	16	of	of	ADP
admet-1022	138	17	them	they	PRON
admet-1022	138	18	(	(	PUNCT
admet-1022	138	19	48.7	48.7	NUM
admet-1022	138	20	%	%	NOUN
admet-1022	138	21	)	)	PUNCT
admet-1022	138	22	showing	show	VERB
admet-1022	138	23	low	low	ADJ
admet-1022	138	24	%	%	NOUN
admet-1022	138	25	fa	fa	NOUN
admet-1022	138	26	.	.	PUNCT
admet-1022	139	1	among	among	ADP
admet-1022	139	2	20	20	NUM
admet-1022	139	3	drugs	drug	NOUN
admet-1022	139	4	with	with	ADP
admet-1022	139	5	twofold	twofold	NOUN
admet-1022	139	6	logps+/mw	logps+/mw	ADJ
admet-1022	139	7	violations	violation	NOUN
admet-1022	139	8	,	,	PUNCT
admet-1022	139	9	four	four	NUM
admet-1022	139	10	(	(	PUNCT
admet-1022	139	11	20	20	NUM
admet-1022	139	12	%	%	NOUN
admet-1022	139	13	)	)	PUNCT
admet-1022	139	14	have	have	VERB
admet-1022	139	15	low	low	ADJ
admet-1022	139	16	absorption	absorption	NOUN
admet-1022	139	17	.	.	PUNCT
admet-1022	140	1	on	on	ADP
admet-1022	140	2	the	the	DET
admet-1022	140	3	other	other	ADJ
admet-1022	140	4	hand	hand	NOUN
admet-1022	140	5	,	,	PUNCT
admet-1022	140	6	among	among	ADP
admet-1022	140	7	the	the	DET
admet-1022	140	8	13	13	NUM
admet-1022	140	9	drugs	drug	NOUN
admet-1022	140	10	with	with	ADP
admet-1022	140	11	logps+<-0.4	logps+<-0.4	NOUN
admet-1022	140	12	and	and	CCONJ
admet-1022	140	13	mw>500	mw>500	PROPN
admet-1022	140	14	,	,	PUNCT
admet-1022	140	15	12	12	NUM
admet-1022	140	16	(	(	PUNCT
admet-1022	140	17	92	92	NUM
admet-1022	140	18	%	%	NOUN
admet-1022	140	19	)	)	PUNCT
admet-1022	140	20	and	and	CCONJ
admet-1022	140	21	all	all	DET
admet-1022	140	22	ten	ten	NUM
admet-1022	140	23	drugs	drug	NOUN
admet-1022	140	24	with	with	ADP
admet-1022	140	25	logps+<-1	logps+<-1	NOUN
admet-1022	140	26	and	and	CCONJ
admet-1022	140	27	mw	mw	ADJ
admet-1022	140	28	>	>	SYM
admet-1022	140	29	500	500	NUM
admet-1022	140	30	display	display	NOUN
admet-1022	140	31	low	low	ADJ
admet-1022	140	32	absorption	absorption	NOUN
admet-1022	140	33	.	.	PUNCT
admet-1022	141	1	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	141	2	tsantili	tsantili	NOUN
admet-1022	141	3	-	-	PUNCT
admet-1022	141	4	kakoulidou	kakoulidou	NOUN
admet-1022	141	5	and	and	CCONJ
admet-1022	141	6	demopoulos	demopoulos	PROPN
admet-1022	141	7	admet	admet	PROPN
admet-1022	141	8	&	&	CCONJ
admet-1022	141	9	dmpk	dmpk	PROPN
admet-1022	141	10	9(3	9(3	NUM
admet-1022	141	11	)	)	PUNCT
admet-1022	141	12	(	(	PUNCT
admet-1022	141	13	2021	2021	NUM
admet-1022	141	14	)	)	PUNCT
admet-1022	141	15	177	177	NUM
admet-1022	141	16	-	-	SYM
admet-1022	141	17	190	190	NUM
admet-1022	141	18	184	184	NUM
admet-1022	141	19	an	an	DET
admet-1022	141	20	analogous	analogous	ADJ
admet-1022	141	21	pattern	pattern	NOUN
admet-1022	141	22	is	be	AUX
admet-1022	141	23	observed	observe	VERB
admet-1022	141	24	if	if	SCONJ
admet-1022	141	25	clogp	clogp	ADJ
admet-1022	141	26	or	or	CCONJ
admet-1022	141	27	mlogp	mlogp	NOUN
admet-1022	141	28	is	be	AUX
admet-1022	141	29	used	use	VERB
admet-1022	141	30	instead	instead	ADV
admet-1022	141	31	of	of	ADP
admet-1022	141	32	logps+	logps+	PROPN
admet-1022	141	33	(	(	PUNCT
admet-1022	141	34	table	table	NOUN
admet-1022	141	35	3	3	NUM
admet-1022	141	36	,	,	PUNCT
admet-1022	141	37	supplementary	supplementary	ADJ
admet-1022	141	38	tables	table	NOUN
admet-1022	141	39	)	)	PUNCT
admet-1022	141	40	,	,	PUNCT
admet-1022	141	41	although	although	SCONJ
admet-1022	141	42	the	the	DET
admet-1022	141	43	cases	case	NOUN
admet-1022	141	44	are	be	AUX
admet-1022	141	45	not	not	PART
admet-1022	141	46	always	always	ADV
admet-1022	141	47	overlapping	overlap	VERB
admet-1022	141	48	.	.	PUNCT
admet-1022	142	1	these	these	DET
admet-1022	142	2	findings	finding	NOUN
admet-1022	142	3	indicate	indicate	VERB
admet-1022	142	4	that	that	SCONJ
admet-1022	142	5	high	high	ADJ
admet-1022	142	6	mw	mw	NOUN
admet-1022	142	7	in	in	ADP
admet-1022	142	8	combination	combination	NOUN
admet-1022	142	9	with	with	ADP
admet-1022	142	10	polarity	polarity	NOUN
admet-1022	142	11	is	be	AUX
admet-1022	142	12	more	more	ADV
admet-1022	142	13	crucial	crucial	ADJ
admet-1022	142	14	than	than	ADP
admet-1022	142	15	high	high	ADJ
admet-1022	142	16	lipophilicity	lipophilicity	NOUN
admet-1022	142	17	for	for	ADP
admet-1022	142	18	absorption	absorption	NOUN
admet-1022	142	19	difficulties	difficulty	NOUN
admet-1022	142	20	.	.	PUNCT
admet-1022	143	1	more	more	ADJ
admet-1022	143	2	to	to	ADP
admet-1022	143	3	the	the	DET
admet-1022	143	4	point	point	NOUN
admet-1022	143	5	,	,	PUNCT
admet-1022	143	6	considering	consider	VERB
admet-1022	143	7	hydrogen	hydrogen	NOUN
admet-1022	143	8	bonding	bonding	NOUN
admet-1022	143	9	potential	potential	NOUN
admet-1022	143	10	,	,	PUNCT
admet-1022	143	11	among	among	ADP
admet-1022	143	12	the	the	DET
admet-1022	143	13	22	22	NUM
admet-1022	143	14	drugs	drug	NOUN
admet-1022	143	15	with	with	ADP
admet-1022	143	16	violations	violation	NOUN
admet-1022	143	17	of	of	ADP
admet-1022	143	18	both	both	PRON
admet-1022	143	19	hydrogen	hydrogen	NOUN
admet-1022	143	20	bond	bond	NOUN
admet-1022	143	21	donor	donor	NOUN
admet-1022	143	22	and	and	CCONJ
admet-1022	143	23	acceptor	acceptor	NOUN
admet-1022	143	24	sites	site	NOUN
admet-1022	143	25	(	(	PUNCT
admet-1022	143	26	hd+[n+o	hd+[n+o	PROPN
admet-1022	143	27	]	]	X
admet-1022	143	28	)	)	PUNCT
admet-1022	143	29	20	20	NUM
admet-1022	143	30	(	(	PUNCT
admet-1022	143	31	91	91	NUM
admet-1022	143	32	%	%	NOUN
admet-1022	143	33	)	)	PUNCT
admet-1022	143	34	show	show	VERB
admet-1022	143	35	low	low	ADJ
admet-1022	143	36	absorption	absorption	NOUN
admet-1022	143	37	.	.	PUNCT
admet-1022	144	1	fraction	fraction	NOUN
admet-1022	144	2	lipophilicity	lipophilicity	PROPN
admet-1022	144	3	index	index	NOUN
admet-1022	144	4	(	(	PUNCT
admet-1022	144	5	fli	fli	NOUN
admet-1022	144	6	)	)	PUNCT
admet-1022	144	7	in	in	ADP
admet-1022	144	8	our	our	PRON
admet-1022	144	9	previous	previous	ADJ
admet-1022	144	10	investigation	investigation	NOUN
admet-1022	144	11	[	[	X
admet-1022	144	12	24	24	NUM
admet-1022	144	13	]	]	PUNCT
admet-1022	144	14	the	the	DET
admet-1022	144	15	drug	drug	NOUN
admet-1022	144	16	-	-	PUNCT
admet-1022	144	17	like	like	ADJ
admet-1022	144	18	fli	fli	NOUN
admet-1022	144	19	range	range	NOUN
admet-1022	144	20	0	0	NUM
admet-1022	144	21	-	-	SYM
admet-1022	144	22	8	8	NUM
admet-1022	144	23	has	have	AUX
admet-1022	144	24	been	be	AUX
admet-1022	144	25	suggested	suggest	VERB
admet-1022	144	26	,	,	PUNCT
admet-1022	144	27	covering	cover	VERB
admet-1022	144	28	89	89	NUM
admet-1022	144	29	%	%	NOUN
admet-1022	144	30	of	of	ADP
admet-1022	144	31	the	the	DET
admet-1022	144	32	drugs	drug	NOUN
admet-1022	144	33	with	with	ADP
admet-1022	144	34	satisfactory	satisfactory	ADJ
admet-1022	144	35	absorption	absorption	NOUN
admet-1022	144	36	.	.	PUNCT
admet-1022	145	1	this	this	DET
admet-1022	145	2	range	range	NOUN
admet-1022	145	3	was	be	AUX
admet-1022	145	4	found	find	VERB
admet-1022	145	5	to	to	PART
admet-1022	145	6	cover	cover	VERB
admet-1022	145	7	73	73	NUM
admet-1022	145	8	%	%	NOUN
admet-1022	145	9	of	of	ADP
admet-1022	145	10	the	the	DET
admet-1022	145	11	drugs	drug	NOUN
admet-1022	145	12	with	with	ADP
admet-1022	145	13	lower	low	ADJ
admet-1022	145	14	absorption	absorption	NOUN
admet-1022	145	15	,	,	PUNCT
admet-1022	145	16	with	with	SCONJ
admet-1022	145	17	the	the	DET
admet-1022	145	18	distribution	distribution	NOUN
admet-1022	145	19	shifted	shift	VERB
admet-1022	145	20	towards	towards	ADP
admet-1022	145	21	negative	negative	ADJ
admet-1022	145	22	fli	fli	ADJ
admet-1022	145	23	values	value	NOUN
admet-1022	145	24	.	.	PUNCT
admet-1022	146	1	the	the	DET
admet-1022	146	2	above	above	ADJ
admet-1022	146	3	findings	finding	NOUN
admet-1022	146	4	were	be	AUX
admet-1022	146	5	further	far	ADV
admet-1022	146	6	supported	support	VERB
admet-1022	146	7	by	by	ADP
admet-1022	146	8	the	the	DET
admet-1022	146	9	extended	extend	VERB
admet-1022	146	10	data	datum	NOUN
admet-1022	146	11	set	set	VERB
admet-1022	146	12	in	in	ADP
admet-1022	146	13	the	the	DET
admet-1022	146	14	present	present	ADJ
admet-1022	146	15	study	study	NOUN
admet-1022	146	16	,	,	PUNCT
admet-1022	146	17	with	with	ADP
admet-1022	146	18	92	92	NUM
admet-1022	146	19	%	%	NOUN
admet-1022	146	20	of	of	ADP
admet-1022	146	21	class	class	NOUN
admet-1022	146	22	1	1	NUM
admet-1022	146	23	drugs	drug	NOUN
admet-1022	146	24	lying	lie	VERB
admet-1022	146	25	within	within	ADP
admet-1022	146	26	the	the	DET
admet-1022	146	27	fli	fli	ADJ
admet-1022	146	28	range	range	NOUN
admet-1022	146	29	0	0	NUM
admet-1022	146	30	-	-	SYM
admet-1022	146	31	8	8	NUM
admet-1022	146	32	.	.	NOUN
admet-1022	146	33	6	6	NUM
admet-1022	146	34	%	%	NOUN
admet-1022	146	35	have	have	VERB
admet-1022	146	36	negative	negative	ADJ
admet-1022	146	37	fli	fli	ADJ
admet-1022	146	38	values	value	NOUN
admet-1022	146	39	and	and	CCONJ
admet-1022	146	40	1	1	NUM
admet-1022	146	41	%	%	NOUN
admet-1022	146	42	fli	fli	NOUN
admet-1022	146	43	values	value	NOUN
admet-1022	146	44	>	>	X
admet-1022	146	45	8	8	X
admet-1022	146	46	.	.	PUNCT
admet-1022	147	1	most	most	ADV
admet-1022	147	2	populated	populated	ADJ
admet-1022	147	3	is	be	AUX
admet-1022	147	4	the	the	DET
admet-1022	147	5	fli	fli	ADJ
admet-1022	147	6	range	range	NOUN
admet-1022	147	7	2	2	NUM
admet-1022	147	8	-	-	SYM
admet-1022	147	9	6	6	NUM
admet-1022	147	10	,	,	PUNCT
admet-1022	147	11	covering	cover	VERB
admet-1022	147	12	66	66	NUM
admet-1022	147	13	%	%	NOUN
admet-1022	147	14	of	of	ADP
admet-1022	147	15	the	the	DET
admet-1022	147	16	drugs	drug	NOUN
admet-1022	147	17	.	.	PUNCT
admet-1022	148	1	for	for	ADP
admet-1022	148	2	class	class	NOUN
admet-1022	148	3	2	2	NUM
admet-1022	148	4	drugs	drug	NOUN
admet-1022	148	5	the	the	DET
admet-1022	148	6	fli	fli	PROPN
admet-1022	148	7	range	range	NOUN
admet-1022	148	8	0	0	NUM
admet-1022	148	9	-	-	SYM
admet-1022	148	10	8	8	NUM
admet-1022	148	11	is	be	AUX
admet-1022	148	12	covered	cover	VERB
admet-1022	148	13	by	by	ADP
admet-1022	148	14	56	56	NUM
admet-1022	148	15	%	%	NOUN
admet-1022	148	16	of	of	ADP
admet-1022	148	17	the	the	DET
admet-1022	148	18	drugs	drug	NOUN
admet-1022	148	19	and	and	CCONJ
admet-1022	148	20	34	34	NUM
admet-1022	148	21	%	%	NOUN
admet-1022	148	22	are	be	AUX
admet-1022	148	23	within	within	ADP
admet-1022	148	24	the	the	DET
admet-1022	148	25	range	range	NOUN
admet-1022	148	26	2	2	NUM
admet-1022	148	27	-	-	SYM
admet-1022	148	28	6	6	NUM
admet-1022	148	29	.	.	NOUN
admet-1022	148	30	1	1	NUM
admet-1022	148	31	%	%	NOUN
admet-1022	148	32	have	have	VERB
admet-1022	148	33	fli	fli	NOUN
admet-1022	148	34	values	value	NOUN
admet-1022	148	35	>	>	X
admet-1022	148	36	8	8	NUM
admet-1022	148	37	,	,	PUNCT
admet-1022	148	38	while	while	SCONJ
admet-1022	148	39	42	42	NUM
admet-1022	148	40	%	%	NOUN
admet-1022	148	41	have	have	VERB
admet-1022	148	42	negative	negative	ADJ
admet-1022	148	43	fli	fli	ADJ
admet-1022	148	44	values	value	NOUN
admet-1022	148	45	(	(	PUNCT
admet-1022	148	46	figure	figure	NOUN
admet-1022	148	47	6	6	NUM
admet-1022	148	48	)	)	PUNCT
admet-1022	148	49	.	.	PUNCT
admet-1022	149	1	the	the	DET
admet-1022	149	2	substantially	substantially	ADV
admet-1022	149	3	lower	low	ADJ
admet-1022	149	4	coverage	coverage	NOUN
admet-1022	149	5	of	of	ADP
admet-1022	149	6	the	the	DET
admet-1022	149	7	drug	drug	NOUN
admet-1022	149	8	-	-	PUNCT
admet-1022	149	9	like	like	ADJ
admet-1022	149	10	fli	fli	NOUN
admet-1022	149	11	range	range	NOUN
admet-1022	149	12	by	by	ADP
admet-1022	149	13	class	class	NOUN
admet-1022	149	14	2	2	NUM
admet-1022	149	15	drugs	drug	NOUN
admet-1022	149	16	,	,	PUNCT
admet-1022	149	17	compared	compare	VERB
admet-1022	149	18	to	to	ADP
admet-1022	149	19	our	our	PRON
admet-1022	149	20	previous	previous	ADJ
admet-1022	149	21	report	report	NOUN
admet-1022	149	22	[	[	X
admet-1022	149	23	24	24	NUM
admet-1022	149	24	]	]	PUNCT
admet-1022	149	25	,	,	PUNCT
admet-1022	149	26	should	should	AUX
admet-1022	149	27	be	be	AUX
admet-1022	149	28	attributed	attribute	VERB
admet-1022	149	29	to	to	ADP
admet-1022	149	30	the	the	DET
admet-1022	149	31	use	use	NOUN
admet-1022	149	32	of	of	ADP
admet-1022	149	33	%	%	INTJ
admet-1022	149	34	fa	fa	INTJ
admet-1022	149	35	in	in	ADP
admet-1022	149	36	this	this	DET
admet-1022	149	37	study	study	NOUN
admet-1022	149	38	instead	instead	ADV
admet-1022	149	39	of	of	ADP
admet-1022	149	40	the	the	DET
admet-1022	149	41	more	more	ADV
admet-1022	149	42	complex	complex	ADJ
admet-1022	149	43	bioavailability	bioavailability	NOUN
admet-1022	149	44	.	.	PUNCT
admet-1022	150	1	analogous	analogous	ADJ
admet-1022	150	2	results	result	NOUN
admet-1022	150	3	are	be	AUX
admet-1022	150	4	obtained	obtain	VERB
admet-1022	150	5	using	use	VERB
admet-1022	150	6	fli	fli	PROPN
admet-1022	150	7	-	-	PUNCT
admet-1022	150	8	c	c	NOUN
admet-1022	150	9	,	,	PUNCT
admet-1022	150	10	which	which	PRON
admet-1022	150	11	is	be	AUX
admet-1022	150	12	based	base	VERB
admet-1022	150	13	on	on	ADP
admet-1022	150	14	clogp	clogp	NOUN
admet-1022	150	15	.	.	PUNCT
admet-1022	151	1	the	the	DET
admet-1022	151	2	fli	fli	PROPN
admet-1022	151	3	-	-	PUNCT
admet-1022	151	4	c	c	NOUN
admet-1022	151	5	drug	drug	NOUN
admet-1022	151	6	-	-	PUNCT
admet-1022	151	7	like	like	ADJ
admet-1022	151	8	range	range	NOUN
admet-1022	151	9	0	0	NUM
admet-1022	151	10	-	-	SYM
admet-1022	151	11	8	8	NUM
admet-1022	151	12	is	be	AUX
admet-1022	151	13	covered	cover	VERB
admet-1022	151	14	by	by	ADP
admet-1022	151	15	91	91	NUM
admet-1022	151	16	%	%	NOUN
admet-1022	151	17	of	of	ADP
admet-1022	151	18	class	class	NOUN
admet-1022	151	19	1	1	NUM
admet-1022	151	20	drugs	drug	NOUN
admet-1022	151	21	,	,	PUNCT
admet-1022	151	22	61	61	NUM
admet-1022	151	23	%	%	NOUN
admet-1022	151	24	being	be	AUX
admet-1022	151	25	within	within	ADP
admet-1022	151	26	the	the	DET
admet-1022	151	27	range	range	NOUN
admet-1022	151	28	2	2	NUM
admet-1022	151	29	-	-	SYM
admet-1022	151	30	6	6	NUM
admet-1022	151	31	.	.	PUNCT
admet-1022	152	1	for	for	ADP
admet-1022	152	2	class	class	NOUN
admet-1022	152	3	2	2	NUM
admet-1022	152	4	the	the	DET
admet-1022	152	5	range	range	NOUN
admet-1022	152	6	0	0	NUM
admet-1022	152	7	-	-	SYM
admet-1022	152	8	8	8	NUM
admet-1022	152	9	is	be	AUX
admet-1022	152	10	covered	cover	VERB
admet-1022	152	11	by	by	ADP
admet-1022	152	12	51	51	NUM
admet-1022	152	13	%	%	NOUN
admet-1022	152	14	of	of	ADP
admet-1022	152	15	the	the	DET
admet-1022	152	16	drugs	drug	NOUN
admet-1022	152	17	,	,	PUNCT
admet-1022	152	18	while	while	SCONJ
admet-1022	152	19	46	46	NUM
admet-1022	152	20	%	%	NOUN
admet-1022	152	21	have	have	VERB
admet-1022	152	22	negative	negative	ADJ
admet-1022	152	23	fli	fli	ADJ
admet-1022	152	24	-	-	PUNCT
admet-1022	152	25	c	c	NOUN
admet-1022	152	26	values	value	NOUN
admet-1022	152	27	(	(	PUNCT
admet-1022	152	28	figure	figure	NOUN
admet-1022	152	29	7	7	NUM
admet-1022	152	30	)	)	PUNCT
admet-1022	152	31	.	.	PUNCT
admet-1022	153	1	based	base	VERB
admet-1022	153	2	on	on	ADP
admet-1022	153	3	the	the	DET
admet-1022	153	4	relatively	relatively	ADV
admet-1022	153	5	lower	low	ADJ
admet-1022	153	6	mlogp	mlogp	ADJ
admet-1022	153	7	values	value	NOUN
admet-1022	153	8	,	,	PUNCT
admet-1022	153	9	fli	fli	ADJ
admet-1022	153	10	-	-	NOUN
admet-1022	153	11	m	m	PROPN
admet-1022	153	12	shapes	shape	VERB
admet-1022	153	13	a	a	DET
admet-1022	153	14	narrower	narrow	ADJ
admet-1022	153	15	drug	drug	NOUN
admet-1022	153	16	-	-	PUNCT
admet-1022	153	17	like	like	ADJ
admet-1022	153	18	range	range	NOUN
admet-1022	153	19	between	between	ADP
admet-1022	153	20	0	0	NUM
admet-1022	153	21	-	-	SYM
admet-1022	153	22	7	7	NUM
admet-1022	153	23	,	,	PUNCT
admet-1022	153	24	covering	cover	VERB
admet-1022	153	25	91	91	NUM
admet-1022	153	26	%	%	NOUN
admet-1022	153	27	of	of	ADP
admet-1022	153	28	class	class	NOUN
admet-1022	153	29	1	1	NUM
admet-1022	153	30	drugs	drug	NOUN
admet-1022	153	31	with	with	ADP
admet-1022	153	32	most	most	ADV
admet-1022	153	33	populated	populate	VERB
admet-1022	153	34	the	the	DET
admet-1022	153	35	region	region	NOUN
admet-1022	153	36	3	3	NUM
admet-1022	153	37	-	-	SYM
admet-1022	153	38	5	5	NUM
admet-1022	153	39	(	(	PUNCT
admet-1022	153	40	46	46	NUM
admet-1022	153	41	%	%	NOUN
admet-1022	153	42	)	)	PUNCT
admet-1022	153	43	.	.	PUNCT
admet-1022	154	1	for	for	ADP
admet-1022	154	2	class	class	NOUN
admet-1022	154	3	2	2	NUM
admet-1022	154	4	drugs	drug	NOUN
admet-1022	154	5	,	,	PUNCT
admet-1022	154	6	53	53	NUM
admet-1022	154	7	%	%	NOUN
admet-1022	154	8	are	be	AUX
admet-1022	154	9	within	within	ADP
admet-1022	154	10	the	the	DET
admet-1022	154	11	range	range	NOUN
admet-1022	154	12	0	0	NUM
admet-1022	154	13	-	-	SYM
admet-1022	154	14	7	7	NUM
admet-1022	154	15	and	and	CCONJ
admet-1022	154	16	45	45	NUM
admet-1022	154	17	%	%	NOUN
admet-1022	154	18	have	have	VERB
admet-1022	154	19	negative	negative	ADJ
admet-1022	154	20	values	value	NOUN
admet-1022	154	21	(	(	PUNCT
admet-1022	154	22	figure	figure	NOUN
admet-1022	154	23	8)	8)	NUM
admet-1022	154	24	.	.	PUNCT
admet-1022	155	1	it	it	PRON
admet-1022	155	2	is	be	AUX
admet-1022	155	3	evident	evident	ADJ
admet-1022	155	4	that	that	SCONJ
admet-1022	155	5	fli	fli	NOUN
admet-1022	155	6	,	,	PUNCT
admet-1022	155	7	fli	fli	NOUN
admet-1022	155	8	-	-	PUNCT
admet-1022	155	9	c	c	NOUN
admet-1022	155	10	and	and	CCONJ
admet-1022	155	11	fli	fli	NOUN
admet-1022	155	12	-	-	PUNCT
admet-1022	155	13	m	m	AUX
admet-1022	155	14	based	base	VERB
admet-1022	155	15	on	on	ADP
admet-1022	155	16	different	different	ADJ
admet-1022	155	17	calculation	calculation	NOUN
admet-1022	155	18	systems	system	NOUN
admet-1022	155	19	show	show	VERB
admet-1022	155	20	the	the	DET
admet-1022	155	21	same	same	ADJ
admet-1022	155	22	performance	performance	NOUN
admet-1022	155	23	,	,	PUNCT
admet-1022	155	24	although	although	SCONJ
admet-1022	155	25	in	in	SCONJ
admet-1022	155	26	fli	fli	PROPN
admet-1022	155	27	-	-	PROPN
admet-1022	155	28	m	m	VERB
admet-1022	155	29	the	the	DET
admet-1022	155	30	drug	drug	NOUN
admet-1022	155	31	-	-	PUNCT
admet-1022	155	32	like	like	ADJ
admet-1022	155	33	range	range	NOUN
admet-1022	155	34	is	be	AUX
admet-1022	155	35	compressed	compress	VERB
admet-1022	155	36	,	,	PUNCT
admet-1022	155	37	in	in	ADP
admet-1022	155	38	agreement	agreement	NOUN
admet-1022	155	39	with	with	ADP
admet-1022	155	40	the	the	DET
admet-1022	155	41	lower	low	ADJ
admet-1022	155	42	mlogp	mlogp	ADJ
admet-1022	155	43	upper	upper	ADJ
admet-1022	155	44	limit	limit	NOUN
admet-1022	155	45	.	.	PUNCT
admet-1022	156	1	thus	thus	ADV
admet-1022	156	2	,	,	PUNCT
admet-1022	156	3	in	in	ADP
admet-1022	156	4	the	the	DET
admet-1022	156	5	next	next	ADJ
admet-1022	156	6	section	section	NOUN
admet-1022	156	7	,	,	PUNCT
admet-1022	156	8	fli	fli	NOUN
admet-1022	156	9	and	and	CCONJ
admet-1022	156	10	fli	fli	NOUN
admet-1022	156	11	-	-	NOUN
admet-1022	156	12	m	m	NOUN
admet-1022	156	13	are	be	AUX
admet-1022	156	14	considered	consider	VERB
admet-1022	156	15	for	for	ADP
admet-1022	156	16	further	further	ADJ
admet-1022	156	17	discussion	discussion	NOUN
admet-1022	156	18	.	.	PUNCT
admet-1022	157	1	figure	figure	VERB
admet-1022	157	2	6	6	NUM
admet-1022	157	3	.	.	PUNCT
admet-1022	158	1	fli	fli	ADJ
admet-1022	158	2	distribution	distribution	NOUN
admet-1022	158	3	for	for	ADP
admet-1022	158	4	class	class	NOUN
admet-1022	158	5	1	1	NUM
admet-1022	158	6	and	and	CCONJ
admet-1022	158	7	class	class	NOUN
admet-1022	158	8	2	2	NUM
admet-1022	158	9	drugs	drug	NOUN
admet-1022	158	10	as	as	ADP
admet-1022	158	11	histograms	histogram	NOUN
admet-1022	158	12	(	(	PUNCT
admet-1022	158	13	left	left	ADJ
admet-1022	158	14	)	)	PUNCT
admet-1022	158	15	and	and	CCONJ
admet-1022	158	16	pie	pie	NOUN
admet-1022	158	17	charts	chart	NOUN
admet-1022	158	18	(	(	PUNCT
admet-1022	158	19	right	right	NOUN
admet-1022	158	20	)	)	PUNCT
admet-1022	158	21	.	.	PUNCT
admet-1022	159	1	admet	admet	PROPN
admet-1022	159	2	&	&	CCONJ
admet-1022	159	3	dmpk	dmpk	PROPN
admet-1022	159	4	9(3	9(3	NUM
admet-1022	159	5	)	)	PUNCT
admet-1022	159	6	(	(	PUNCT
admet-1022	159	7	2021	2021	NUM
admet-1022	159	8	)	)	PUNCT
admet-1022	159	9	177	177	NUM
admet-1022	159	10	-	-	SYM
admet-1022	159	11	190	190	NUM
admet-1022	159	12	drug	drug	NOUN
admet-1022	159	13	-	-	PUNCT
admet-1022	159	14	likeness	likeness	NOUN
admet-1022	159	15	and	and	CCONJ
admet-1022	159	16	fraction	fraction	NOUN
admet-1022	159	17	lipophilicity	lipophilicity	PROPN
admet-1022	159	18	index	index	NOUN
admet-1022	159	19	doi	doi	NOUN
admet-1022	159	20	:	:	PUNCT
admet-1022	159	21	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	159	22	185	185	NUM
admet-1022	159	23	figure	figure	NOUN
admet-1022	159	24	7	7	NUM
admet-1022	159	25	.	.	PUNCT
admet-1022	160	1	fli	fli	ADJ
admet-1022	160	2	-	-	PUNCT
admet-1022	160	3	c	c	NOUN
admet-1022	160	4	distribution	distribution	NOUN
admet-1022	160	5	for	for	ADP
admet-1022	160	6	class	class	NOUN
admet-1022	160	7	1	1	NUM
admet-1022	160	8	and	and	CCONJ
admet-1022	160	9	class	class	NOUN
admet-1022	160	10	2	2	NUM
admet-1022	160	11	drugs	drug	NOUN
admet-1022	160	12	as	as	ADP
admet-1022	160	13	histograms	histogram	NOUN
admet-1022	160	14	(	(	PUNCT
admet-1022	160	15	left	left	ADJ
admet-1022	160	16	)	)	PUNCT
admet-1022	160	17	and	and	CCONJ
admet-1022	160	18	pie	pie	NOUN
admet-1022	160	19	charts	chart	NOUN
admet-1022	160	20	(	(	PUNCT
admet-1022	160	21	right	right	ADJ
admet-1022	160	22	)	)	PUNCT
admet-1022	160	23	.	.	PUNCT
admet-1022	161	1	figure	figure	VERB
admet-1022	161	2	8	8	NUM
admet-1022	161	3	.	.	PUNCT
admet-1022	162	1	fli	fli	ADJ
admet-1022	162	2	-	-	PUNCT
admet-1022	162	3	m	m	NOUN
admet-1022	162	4	distribution	distribution	NOUN
admet-1022	162	5	for	for	ADP
admet-1022	162	6	class	class	NOUN
admet-1022	162	7	1	1	NUM
admet-1022	162	8	and	and	CCONJ
admet-1022	162	9	class	class	NOUN
admet-1022	162	10	2	2	NUM
admet-1022	162	11	drugs	drug	NOUN
admet-1022	162	12	as	as	ADP
admet-1022	162	13	histograms	histogram	NOUN
admet-1022	162	14	(	(	PUNCT
admet-1022	162	15	left	left	ADJ
admet-1022	162	16	)	)	PUNCT
admet-1022	162	17	and	and	CCONJ
admet-1022	162	18	pie	pie	NOUN
admet-1022	162	19	charts	chart	NOUN
admet-1022	162	20	(	(	PUNCT
admet-1022	162	21	right	right	NOUN
admet-1022	162	22	)	)	PUNCT
admet-1022	162	23	.	.	PUNCT
admet-1022	163	1	fli	fli	NOUN
admet-1022	163	2	as	as	ADP
admet-1022	163	3	a	a	DET
admet-1022	163	4	combined	combine	VERB
admet-1022	163	5	metric	metric	ADJ
admet-1022	163	6	comparison	comparison	NOUN
admet-1022	163	7	with	with	ADP
admet-1022	163	8	ro5	ro5	NOUN
admet-1022	163	9	considering	consider	VERB
admet-1022	163	10	ionizable	ionizable	ADJ
admet-1022	163	11	drugs	drug	NOUN
admet-1022	163	12	,	,	PUNCT
admet-1022	163	13	the	the	DET
admet-1022	163	14	drug	drug	NOUN
admet-1022	163	15	-	-	PUNCT
admet-1022	163	16	like	like	ADJ
admet-1022	163	17	fli	fli	NOUN
admet-1022	163	18	range	range	NOUN
admet-1022	163	19	0	0	NUM
admet-1022	163	20	-	-	SYM
admet-1022	163	21	8	8	NUM
admet-1022	163	22	expands	expand	VERB
admet-1022	163	23	the	the	DET
admet-1022	163	24	lipophilicity	lipophilicity	NOUN
admet-1022	163	25	cutoff	cutoff	NOUN
admet-1022	163	26	values	value	NOUN
admet-1022	163	27	beyond	beyond	ADP
admet-1022	163	28	5	5	NUM
admet-1022	163	29	(	(	PUNCT
admet-1022	163	30	or	or	CCONJ
admet-1022	163	31	4.15	4.15	NUM
admet-1022	163	32	for	for	ADP
admet-1022	163	33	mlogp	mlogp	NOUN
admet-1022	163	34	)	)	PUNCT
admet-1022	163	35	.	.	PUNCT
admet-1022	164	1	in	in	ADP
admet-1022	164	2	fact	fact	NOUN
admet-1022	164	3	,	,	PUNCT
admet-1022	164	4	log	log	VERB
admet-1022	164	5	p	p	NOUN
admet-1022	164	6	values	value	NOUN
admet-1022	164	7	(	(	PUNCT
admet-1022	164	8	logps+	logps+	NOUN
admet-1022	164	9	or	or	CCONJ
admet-1022	164	10	clogp	clogp	ADJ
admet-1022	164	11	)	)	PUNCT
admet-1022	164	12	expand	expand	VERB
admet-1022	164	13	to	to	ADP
admet-1022	164	14	7.7	7.7	NUM
admet-1022	164	15	,	,	PUNCT
admet-1022	164	16	provided	provide	VERB
admet-1022	164	17	that	that	SCONJ
admet-1022	164	18	the	the	DET
admet-1022	164	19	compounds	compound	NOUN
admet-1022	164	20	do	do	AUX
admet-1022	164	21	not	not	PART
admet-1022	164	22	exhibit	exhibit	VERB
admet-1022	164	23	higher	high	ADJ
admet-1022	164	24	ionization	ionization	NOUN
admet-1022	164	25	than	than	ADP
admet-1022	164	26	50	50	NUM
admet-1022	164	27	%	%	NOUN
admet-1022	164	28	(	(	PUNCT
admet-1022	164	29	considering	consider	VERB
admet-1022	164	30	that	that	SCONJ
admet-1022	164	31	at	at	ADP
admet-1022	164	32	50	50	NUM
admet-1022	164	33	%	%	NOUN
admet-1022	164	34	ionization	ionization	NOUN
admet-1022	164	35	,	,	PUNCT
admet-1022	164	36	lipophilicity	lipophilicity	NOUN
admet-1022	164	37	decreases	decrease	VERB
admet-1022	164	38	by	by	ADP
admet-1022	164	39	0.3	0.3	NUM
admet-1022	164	40	log	log	NOUN
admet-1022	164	41	units	unit	NOUN
admet-1022	164	42	)	)	PUNCT
admet-1022	164	43	or	or	CCONJ
admet-1022	164	44	to	to	ADP
admet-1022	164	45	slightly	slightly	ADV
admet-1022	164	46	higher	high	ADJ
admet-1022	164	47	(	(	PUNCT
admet-1022	164	48	7.87	7.87	NUM
admet-1022	164	49	)	)	PUNCT
admet-1022	164	50	if	if	SCONJ
admet-1022	164	51	30	30	NUM
admet-1022	164	52	%	%	NOUN
admet-1022	164	53	ionization	ionization	NOUN
admet-1022	164	54	is	be	AUX
admet-1022	164	55	considered	consider	VERB
admet-1022	164	56	.	.	PUNCT
admet-1022	165	1	for	for	ADP
admet-1022	165	2	mlogp	mlogp	NOUN
admet-1022	165	3	the	the	DET
admet-1022	165	4	upper	upper	ADJ
admet-1022	165	5	limits	limit	NOUN
admet-1022	165	6	expand	expand	VERB
admet-1022	165	7	to	to	ADP
admet-1022	165	8	6.7	6.7	NUM
admet-1022	165	9	or	or	CCONJ
admet-1022	165	10	6.87	6.87	NUM
admet-1022	165	11	.	.	PUNCT
admet-1022	166	1	such	such	ADJ
admet-1022	166	2	hard	hard	ADJ
admet-1022	166	3	limit	limit	NOUN
admet-1022	166	4	values	value	NOUN
admet-1022	166	5	are	be	AUX
admet-1022	166	6	not	not	PART
admet-1022	166	7	realistic	realistic	ADJ
admet-1022	166	8	for	for	ADP
admet-1022	166	9	the	the	DET
admet-1022	166	10	design	design	NOUN
admet-1022	166	11	of	of	ADP
admet-1022	166	12	new	new	ADJ
admet-1022	166	13	drugs	drug	NOUN
admet-1022	166	14	.	.	PUNCT
admet-1022	167	1	our	our	PRON
admet-1022	167	2	proposition	proposition	NOUN
admet-1022	167	3	is	be	AUX
admet-1022	167	4	to	to	PART
admet-1022	167	5	think	think	VERB
admet-1022	167	6	in	in	ADP
admet-1022	167	7	terms	term	NOUN
admet-1022	167	8	of	of	ADP
admet-1022	167	9	combinations	combination	NOUN
admet-1022	167	10	of	of	ADP
admet-1022	167	11	properties	property	NOUN
admet-1022	167	12	rather	rather	ADV
admet-1022	167	13	than	than	ADP
admet-1022	167	14	single	single	ADJ
admet-1022	167	15	properties	property	NOUN
admet-1022	167	16	.	.	PUNCT
admet-1022	168	1	in	in	ADP
admet-1022	168	2	this	this	DET
admet-1022	168	3	aspect	aspect	NOUN
admet-1022	168	4	,	,	PUNCT
admet-1022	168	5	fli	fli	NOUN
admet-1022	168	6	represents	represent	VERB
admet-1022	168	7	a	a	DET
admet-1022	168	8	weighted	weight	VERB
admet-1022	168	9	combination	combination	NOUN
admet-1022	168	10	of	of	ADP
admet-1022	168	11	log	log	NOUN
admet-1022	168	12	p	p	PROPN
admet-1022	168	13	with	with	ADP
admet-1022	168	14	log	log	PROPN
admet-1022	168	15	d	d	PROPN
admet-1022	168	16	,	,	PUNCT
admet-1022	168	17	suggesting	suggest	VERB
admet-1022	168	18	reduced	reduce	VERB
admet-1022	168	19	ionization	ionization	NOUN
admet-1022	168	20	for	for	ADP
admet-1022	168	21	drugs	drug	NOUN
admet-1022	168	22	at	at	ADP
admet-1022	168	23	the	the	DET
admet-1022	168	24	upper	upper	ADJ
admet-1022	168	25	lipophilicity	lipophilicity	NOUN
admet-1022	168	26	extremes	extreme	NOUN
admet-1022	168	27	.	.	PUNCT
admet-1022	169	1	on	on	ADP
admet-1022	169	2	the	the	DET
admet-1022	169	3	other	other	ADJ
admet-1022	169	4	hand	hand	NOUN
admet-1022	169	5	,	,	PUNCT
admet-1022	169	6	low	low	ADJ
admet-1022	169	7	log	log	NOUN
admet-1022	169	8	p	p	NOUN
admet-1022	169	9	and	and	CCONJ
admet-1022	169	10	log	log	NOUN
admet-1022	169	11	d	d	NOUN
admet-1022	169	12	values	value	NOUN
admet-1022	169	13	leading	lead	VERB
admet-1022	169	14	to	to	ADP
admet-1022	169	15	negative	negative	ADJ
admet-1022	169	16	fli	fli	ADJ
admet-1022	169	17	values	value	NOUN
admet-1022	169	18	are	be	AUX
admet-1022	169	19	more	more	ADV
admet-1022	169	20	discriminating	discriminating	ADJ
admet-1022	169	21	for	for	ADP
admet-1022	169	22	low	low	ADJ
admet-1022	169	23	absorption	absorption	NOUN
admet-1022	169	24	levels	level	NOUN
admet-1022	169	25	.	.	PUNCT
admet-1022	170	1	in	in	ADP
admet-1022	170	2	figure	figure	NOUN
admet-1022	170	3	9	9	NUM
admet-1022	170	4	,	,	PUNCT
admet-1022	170	5	the	the	DET
admet-1022	170	6	fli	fli	ADJ
admet-1022	170	7	values	value	NOUN
admet-1022	170	8	inside	inside	ADP
admet-1022	170	9	the	the	DET
admet-1022	170	10	drug	drug	NOUN
admet-1022	170	11	-	-	PUNCT
admet-1022	170	12	like	like	ADJ
admet-1022	170	13	range	range	NOUN
admet-1022	170	14	along	along	ADP
admet-1022	170	15	with	with	ADP
admet-1022	170	16	the	the	DET
admet-1022	170	17	associated	associated	ADJ
admet-1022	170	18	δ(log	δ(log	NOUN
admet-1022	170	19	p	p	NOUN
admet-1022	170	20	–	–	PUNCT
admet-1022	170	21	log	log	NOUN
admet-1022	170	22	d	d	NOUN
admet-1022	170	23	)	)	PUNCT
admet-1022	170	24	levels	level	NOUN
admet-1022	170	25	for	for	ADP
admet-1022	170	26	class	class	NOUN
admet-1022	170	27	1	1	NUM
admet-1022	170	28	drugs	drug	NOUN
admet-1022	170	29	are	be	AUX
admet-1022	170	30	presented	present	VERB
admet-1022	170	31	.	.	PUNCT
admet-1022	171	1	for	for	ADP
admet-1022	171	2	drugs	drug	NOUN
admet-1022	171	3	with	with	ADP
admet-1022	171	4	logps+>5	logps+>5	ADJ
admet-1022	171	5	δ(log	δ(log	PROPN
admet-1022	171	6	p	p	NOUN
admet-1022	171	7	–	–	PUNCT
admet-1022	171	8	log	log	NOUN
admet-1022	171	9	d	d	NOUN
admet-1022	171	10	)	)	PUNCT
admet-1022	171	11	values	value	NOUN
admet-1022	171	12	do	do	AUX
admet-1022	171	13	not	not	PART
admet-1022	171	14	exceed	exceed	VERB
admet-1022	171	15	2.7	2.7	NUM
admet-1022	171	16	,	,	PUNCT
admet-1022	171	17	with	with	ADP
admet-1022	171	18	most	most	ADJ
admet-1022	171	19	drugs	drug	NOUN
admet-1022	171	20	showing	show	VERB
admet-1022	171	21	δ(log	δ(log	NOUN
admet-1022	171	22	p	p	NOUN
admet-1022	171	23	–	–	PUNCT
admet-1022	171	24	log	log	NOUN
admet-1022	171	25	d)<2	d)<2	PROPN
admet-1022	171	26	.	.	PUNCT
admet-1022	172	1	although	although	SCONJ
admet-1022	172	2	the	the	DET
admet-1022	172	3	majority	majority	NOUN
admet-1022	172	4	for	for	ADP
admet-1022	172	5	class	class	NOUN
admet-1022	172	6	1	1	NUM
admet-1022	172	7	drugs	drug	NOUN
admet-1022	172	8	with	with	ADP
admet-1022	172	9	logps+≤5	logps+≤5	NOUN
admet-1022	172	10	has	have	VERB
admet-1022	172	11	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	172	12	tsantili	tsantili	NOUN
admet-1022	172	13	-	-	PUNCT
admet-1022	172	14	kakoulidou	kakoulidou	NOUN
admet-1022	172	15	and	and	CCONJ
admet-1022	172	16	demopoulos	demopoulos	PROPN
admet-1022	172	17	admet	admet	PROPN
admet-1022	172	18	&	&	CCONJ
admet-1022	172	19	dmpk	dmpk	PROPN
admet-1022	172	20	9(3	9(3	NUM
admet-1022	172	21	)	)	PUNCT
admet-1022	172	22	(	(	PUNCT
admet-1022	172	23	2021	2021	NUM
admet-1022	172	24	)	)	PUNCT
admet-1022	172	25	177	177	NUM
admet-1022	172	26	-	-	SYM
admet-1022	172	27	190	190	NUM
admet-1022	172	28	186	186	NUM
admet-1022	172	29	also	also	ADV
admet-1022	172	30	δ(log	δ(log	NOUN
admet-1022	172	31	p	p	NOUN
admet-1022	172	32	–	–	PUNCT
admet-1022	172	33	log	log	PROPN
admet-1022	172	34	d)<2	d)<2	PROPN
admet-1022	172	35	,	,	PUNCT
admet-1022	172	36	67	67	NUM
admet-1022	172	37	drugs	drug	NOUN
admet-1022	172	38	show	show	VERB
admet-1022	172	39	higher	high	ADJ
admet-1022	172	40	ionization	ionization	NOUN
admet-1022	172	41	.	.	PUNCT
admet-1022	173	1	similarly	similarly	ADV
admet-1022	173	2	,	,	PUNCT
admet-1022	173	3	no	no	DET
admet-1022	173	4	class	class	NOUN
admet-1022	173	5	1	1	NUM
admet-1022	173	6	drugs	drug	NOUN
admet-1022	173	7	with	with	ADP
admet-1022	173	8	mlogp	mlogp	PROPN
admet-1022	173	9	>	>	X
admet-1022	173	10	4.15	4.15	NUM
admet-1022	173	11	have	have	VERB
admet-1022	173	12	δ(log	δ(log	NOUN
admet-1022	173	13	p	p	NOUN
admet-1022	173	14	–	–	PUNCT
admet-1022	173	15	log	log	NOUN
admet-1022	173	16	d)>2.5	d)>2.5	NOUN
admet-1022	173	17	,	,	PUNCT
admet-1022	173	18	while	while	SCONJ
admet-1022	173	19	for	for	ADP
admet-1022	173	20	14	14	NUM
admet-1022	173	21	drugs	drug	NOUN
admet-1022	173	22	with	with	ADP
admet-1022	173	23	mlogp≤4.15	mlogp≤4.15	NOUN
admet-1022	173	24	δ(log	δ(log	PROPN
admet-1022	173	25	p	p	NOUN
admet-1022	173	26	–	–	PUNCT
admet-1022	173	27	log	log	NOUN
admet-1022	173	28	d	d	NOUN
admet-1022	173	29	)	)	PUNCT
admet-1022	173	30	exceeds	exceed	VERB
admet-1022	173	31	2.5	2.5	NUM
admet-1022	173	32	.	.	PUNCT
admet-1022	174	1	figure	figure	NOUN
admet-1022	174	2	9	9	NUM
admet-1022	174	3	.	.	PUNCT
admet-1022	175	1	left	leave	VERB
admet-1022	175	2	:	:	PUNCT
admet-1022	175	3	ionization	ionization	NOUN
admet-1022	175	4	pattern	pattern	NOUN
admet-1022	175	5	for	for	ADP
admet-1022	175	6	class	class	NOUN
admet-1022	175	7	1	1	NUM
admet-1022	175	8	drugs	drug	NOUN
admet-1022	175	9	,	,	PUNCT
admet-1022	175	10	according	accord	VERB
admet-1022	175	11	to	to	ADP
admet-1022	175	12	fli	fli	NOUN
admet-1022	175	13	levels	level	NOUN
admet-1022	175	14	within	within	ADP
admet-1022	175	15	the	the	DET
admet-1022	175	16	drug	drug	NOUN
admet-1022	175	17	-	-	PUNCT
admet-1022	175	18	like	like	ADJ
admet-1022	175	19	range	range	NOUN
admet-1022	175	20	,	,	PUNCT
admet-1022	175	21	for	for	ADP
admet-1022	175	22	subsets	subset	NOUN
admet-1022	175	23	including	include	VERB
admet-1022	175	24	drugs	drug	NOUN
admet-1022	175	25	with	with	ADP
admet-1022	175	26	logps	logps	NOUN
admet-1022	175	27	+	+	CCONJ
admet-1022	175	28	>	>	SYM
admet-1022	175	29	5	5	NUM
admet-1022	175	30	and	and	CCONJ
admet-1022	175	31	logps	logps	NOUN
admet-1022	175	32	+	+	CCONJ
admet-1022	175	33	≤5	≤5	VERB
admet-1022	175	34	respectively	respectively	ADV
admet-1022	175	35	.	.	PUNCT
admet-1022	176	1	right	right	ADJ
admet-1022	176	2	:	:	PUNCT
admet-1022	176	3	ionization	ionization	NOUN
admet-1022	176	4	pattern	pattern	NOUN
admet-1022	176	5	for	for	ADP
admet-1022	176	6	class	class	NOUN
admet-1022	176	7	1	1	NUM
admet-1022	176	8	drugs	drug	NOUN
admet-1022	176	9	,	,	PUNCT
admet-1022	176	10	according	accord	VERB
admet-1022	176	11	to	to	ADP
admet-1022	176	12	fli	fli	ADJ
admet-1022	176	13	-	-	PUNCT
admet-1022	176	14	m	m	PROPN
admet-1022	176	15	levels	level	NOUN
admet-1022	176	16	within	within	ADP
admet-1022	176	17	the	the	DET
admet-1022	176	18	drug	drug	NOUN
admet-1022	176	19	-	-	PUNCT
admet-1022	176	20	like	like	ADJ
admet-1022	176	21	range	range	NOUN
admet-1022	176	22	,	,	PUNCT
admet-1022	176	23	for	for	ADP
admet-1022	176	24	subsets	subset	NOUN
admet-1022	176	25	including	include	VERB
admet-1022	176	26	drugs	drug	NOUN
admet-1022	176	27	with	with	ADP
admet-1022	176	28	logps	logps	NOUN
admet-1022	176	29	+	+	CCONJ
admet-1022	176	30	>	>	X
admet-1022	176	31	4.15	4.15	NUM
admet-1022	176	32	and	and	CCONJ
admet-1022	176	33	logps	logps	NOUN
admet-1022	176	34	+	+	CCONJ
admet-1022	176	35	≤4.15	≤4.15	NOUN
admet-1022	176	36	respectively	respectively	ADV
admet-1022	176	37	.	.	PUNCT
admet-1022	177	1	in	in	ADP
admet-1022	177	2	figure	figure	NOUN
admet-1022	177	3	10	10	NUM
admet-1022	177	4	,	,	PUNCT
admet-1022	177	5	the	the	DET
admet-1022	177	6	combination	combination	NOUN
admet-1022	177	7	of	of	ADP
admet-1022	177	8	fli	fli	NOUN
admet-1022	177	9	and	and	CCONJ
admet-1022	177	10	rule	rule	NOUN
admet-1022	177	11	of	of	ADP
admet-1022	177	12	five	five	NUM
admet-1022	177	13	(	(	PUNCT
admet-1022	177	14	scorero5	scorero5	PROPN
admet-1022	177	15	/	/	SYM
admet-1022	177	16	logps+	logps+	NOUN
admet-1022	177	17	)	)	PUNCT
admet-1022	177	18	is	be	AUX
admet-1022	177	19	shown	show	VERB
admet-1022	177	20	for	for	ADP
admet-1022	177	21	class	class	NOUN
admet-1022	177	22	1	1	NUM
admet-1022	177	23	and	and	CCONJ
admet-1022	177	24	the	the	DET
admet-1022	177	25	subset	subset	NOUN
admet-1022	177	26	,	,	PUNCT
admet-1022	177	27	including	include	VERB
admet-1022	177	28	fli	fli	ADJ
admet-1022	177	29	values	value	NOUN
admet-1022	177	30	inside	inside	ADP
admet-1022	177	31	the	the	DET
admet-1022	177	32	drug	drug	NOUN
admet-1022	177	33	-	-	PUNCT
admet-1022	177	34	like	like	ADJ
admet-1022	177	35	range	range	NOUN
admet-1022	177	36	for	for	ADP
admet-1022	177	37	class	class	NOUN
admet-1022	177	38	2	2	NUM
admet-1022	177	39	and	and	CCONJ
admet-1022	177	40	the	the	DET
admet-1022	177	41	subset	subset	NOUN
admet-1022	177	42	including	include	VERB
admet-1022	177	43	drugs	drug	NOUN
admet-1022	177	44	outside	outside	ADP
admet-1022	177	45	the	the	DET
admet-1022	177	46	drug	drug	NOUN
admet-1022	177	47	-	-	PUNCT
admet-1022	177	48	like	like	ADJ
admet-1022	177	49	range	range	NOUN
admet-1022	177	50	.	.	PUNCT
admet-1022	178	1	it	it	PRON
admet-1022	178	2	is	be	AUX
admet-1022	178	3	shown	show	VERB
admet-1022	178	4	that	that	SCONJ
admet-1022	178	5	25	25	NUM
admet-1022	178	6	drugs	drug	NOUN
admet-1022	178	7	(	(	PUNCT
admet-1022	178	8	5.2	5.2	NUM
admet-1022	178	9	%	%	NOUN
admet-1022	178	10	)	)	PUNCT
admet-1022	178	11	in	in	ADP
admet-1022	178	12	class	class	NOUN
admet-1022	178	13	1	1	NUM
admet-1022	178	14	drug	drug	NOUN
admet-1022	178	15	-	-	PUNCT
admet-1022	178	16	like	like	ADJ
admet-1022	178	17	subset	subset	NOUN
admet-1022	178	18	(	(	PUNCT
admet-1022	178	19	figure	figure	NOUN
admet-1022	178	20	10b	10b	NOUN
admet-1022	178	21	)	)	PUNCT
admet-1022	178	22	display	display	NOUN
admet-1022	178	23	more	more	ADV
admet-1022	178	24	than	than	ADP
admet-1022	178	25	twofold	twofold	ADJ
admet-1022	178	26	ro5	ro5	ADJ
admet-1022	178	27	violation	violation	NOUN
admet-1022	178	28	,	,	PUNCT
admet-1022	178	29	12	12	NUM
admet-1022	178	30	out	out	ADP
admet-1022	178	31	of	of	ADP
admet-1022	178	32	them	they	PRON
admet-1022	178	33	involving	involve	VERB
admet-1022	178	34	logps+	logps+	PROPN
admet-1022	178	35	and	and	CCONJ
admet-1022	178	36	mw	mw	PROPN
admet-1022	178	37	.	.	PROPN
admet-1022	178	38	considering	consider	VERB
admet-1022	178	39	the	the	DET
admet-1022	178	40	fli	fli	PROPN
admet-1022	178	41	metric	metric	NOUN
admet-1022	178	42	,	,	PUNCT
admet-1022	178	43	these	these	DET
admet-1022	178	44	12	12	NUM
admet-1022	178	45	drugs	drug	NOUN
admet-1022	178	46	would	would	AUX
admet-1022	178	47	not	not	PART
admet-1022	178	48	receive	receive	VERB
admet-1022	178	49	a	a	DET
admet-1022	178	50	second	second	ADJ
admet-1022	178	51	alert	alert	NOUN
admet-1022	178	52	,	,	PUNCT
admet-1022	178	53	and	and	CCONJ
admet-1022	178	54	thus	thus	ADV
admet-1022	178	55	they	they	PRON
admet-1022	178	56	would	would	AUX
admet-1022	178	57	not	not	PART
admet-1022	178	58	be	be	AUX
admet-1022	178	59	considered	consider	VERB
admet-1022	178	60	bro5	bro5	NOUN
admet-1022	178	61	drugs	drug	NOUN
admet-1022	178	62	.	.	PUNCT
admet-1022	179	1	on	on	ADP
admet-1022	179	2	the	the	DET
admet-1022	179	3	other	other	ADJ
admet-1022	179	4	hand	hand	NOUN
admet-1022	179	5	,	,	PUNCT
admet-1022	179	6	33	33	NUM
admet-1022	179	7	drugs	drug	NOUN
admet-1022	179	8	(	(	PUNCT
admet-1022	179	9	28	28	NUM
admet-1022	179	10	%	%	NOUN
admet-1022	179	11	)	)	PUNCT
admet-1022	179	12	of	of	ADP
admet-1022	179	13	class	class	NOUN
admet-1022	179	14	2	2	NUM
admet-1022	179	15	(	(	PUNCT
admet-1022	179	16	figure	figure	NOUN
admet-1022	179	17	10d	10d	NUM
admet-1022	179	18	)	)	PUNCT
admet-1022	179	19	show	show	VERB
admet-1022	179	20	none	none	NOUN
admet-1022	179	21	or	or	CCONJ
admet-1022	179	22	one	one	NUM
admet-1022	179	23	ro5	ro5	ADJ
admet-1022	179	24	violation	violation	NOUN
admet-1022	179	25	.	.	PUNCT
admet-1022	180	1	however	however	ADV
admet-1022	180	2	,	,	PUNCT
admet-1022	180	3	in	in	ADP
admet-1022	180	4	terms	term	NOUN
admet-1022	180	5	of	of	ADP
admet-1022	180	6	their	their	PRON
admet-1022	180	7	fli	fli	ADJ
admet-1022	180	8	values	value	NOUN
admet-1022	180	9	,	,	PUNCT
admet-1022	180	10	a	a	DET
admet-1022	180	11	warning	warning	NOUN
admet-1022	180	12	should	should	AUX
admet-1022	180	13	be	be	AUX
admet-1022	180	14	set	set	VERB
admet-1022	180	15	for	for	ADP
admet-1022	180	16	these	these	DET
admet-1022	180	17	drugs	drug	NOUN
admet-1022	180	18	according	accord	VERB
admet-1022	180	19	to	to	ADP
admet-1022	180	20	this	this	DET
admet-1022	180	21	metric	metric	NOUN
admet-1022	180	22	.	.	PUNCT
admet-1022	181	1	considering	consider	VERB
admet-1022	181	2	fli	fli	PROPN
admet-1022	181	3	-	-	PUNCT
admet-1022	181	4	m	m	PROPN
admet-1022	181	5	,	,	PUNCT
admet-1022	181	6	16	16	NUM
admet-1022	181	7	class	class	NOUN
admet-1022	181	8	1	1	NUM
admet-1022	181	9	drugs	drug	NOUN
admet-1022	181	10	within	within	ADP
admet-1022	181	11	the	the	DET
admet-1022	181	12	drug	drug	NOUN
admet-1022	181	13	-	-	PUNCT
admet-1022	181	14	like	like	ADJ
admet-1022	181	15	range	range	NOUN
admet-1022	181	16	(	(	PUNCT
admet-1022	181	17	figure	figure	NOUN
admet-1022	181	18	11b	11b	NOUN
admet-1022	181	19	)	)	PUNCT
admet-1022	181	20	show	show	VERB
admet-1022	181	21	the	the	DET
admet-1022	181	22	twofold	twofold	ADJ
admet-1022	181	23	violation	violation	NOUN
admet-1022	181	24	of	of	ADP
admet-1022	181	25	the	the	DET
admet-1022	181	26	corresponding	corresponding	ADJ
admet-1022	181	27	ro5	ro5	ADJ
admet-1022	181	28	score	score	NOUN
admet-1022	181	29	,	,	PUNCT
admet-1022	181	30	5	5	NUM
admet-1022	181	31	of	of	ADP
admet-1022	181	32	them	they	PRON
admet-1022	181	33	involving	involve	VERB
admet-1022	181	34	mlogp	mlogp	NOUN
admet-1022	181	35	>	>	NOUN
admet-1022	181	36	4.15	4.15	NUM
admet-1022	181	37	.	.	PUNCT
admet-1022	182	1	on	on	ADP
admet-1022	182	2	the	the	DET
admet-1022	182	3	other	other	ADJ
admet-1022	182	4	hand	hand	NOUN
admet-1022	182	5	,	,	PUNCT
admet-1022	182	6	there	there	PRON
admet-1022	182	7	should	should	AUX
admet-1022	182	8	be	be	AUX
admet-1022	182	9	a	a	DET
admet-1022	182	10	warning	warning	NOUN
admet-1022	182	11	for	for	ADP
admet-1022	182	12	37	37	NUM
admet-1022	182	13	drugs	drug	NOUN
admet-1022	182	14	of	of	ADP
admet-1022	182	15	class	class	NOUN
admet-1022	182	16	2	2	NUM
admet-1022	182	17	outside	outside	ADP
admet-1022	182	18	the	the	DET
admet-1022	182	19	drug	drug	NOUN
admet-1022	182	20	-	-	PUNCT
admet-1022	182	21	like	like	ADJ
admet-1022	182	22	range	range	NOUN
admet-1022	182	23	,	,	PUNCT
admet-1022	182	24	although	although	SCONJ
admet-1022	182	25	they	they	PRON
admet-1022	182	26	show	show	VERB
admet-1022	182	27	0	0	NUM
admet-1022	182	28	or	or	CCONJ
admet-1022	182	29	1	1	NUM
admet-1022	182	30	ro5	ro5	ADJ
admet-1022	182	31	violation	violation	NOUN
admet-1022	182	32	(	(	PUNCT
admet-1022	182	33	figure	figure	NOUN
admet-1022	182	34	11d	11d	NOUN
admet-1022	182	35	)	)	PUNCT
admet-1022	182	36	.	.	PUNCT
admet-1022	183	1	considering	consider	VERB
admet-1022	183	2	the	the	DET
admet-1022	183	3	merits	merit	NOUN
admet-1022	183	4	of	of	ADP
admet-1022	183	5	fli	fli	NOUN
admet-1022	183	6	as	as	ADP
admet-1022	183	7	a	a	DET
admet-1022	183	8	composite	composite	ADJ
admet-1022	183	9	metric	metric	NOUN
admet-1022	183	10	and	and	CCONJ
admet-1022	183	11	in	in	ADP
admet-1022	183	12	the	the	DET
admet-1022	183	13	light	light	NOUN
admet-1022	183	14	of	of	ADP
admet-1022	183	15	the	the	DET
admet-1022	183	16	combination	combination	NOUN
admet-1022	183	17	mentioned	mention	VERB
admet-1022	183	18	above	above	ADP
admet-1022	183	19	of	of	ADP
admet-1022	183	20	high	high	ADJ
admet-1022	183	21	mw	mw	NOUN
admet-1022	183	22	with	with	ADP
admet-1022	183	23	high	high	ADJ
admet-1022	183	24	polarity	polarity	NOUN
admet-1022	183	25	as	as	ADP
admet-1022	183	26	a	a	DET
admet-1022	183	27	crucial	crucial	ADJ
admet-1022	183	28	issue	issue	NOUN
admet-1022	183	29	for	for	ADP
admet-1022	183	30	low	low	ADJ
admet-1022	183	31	absorption	absorption	NOUN
admet-1022	183	32	,	,	PUNCT
admet-1022	183	33	we	we	PRON
admet-1022	183	34	go	go	VERB
admet-1022	183	35	a	a	DET
admet-1022	183	36	step	step	NOUN
admet-1022	183	37	further	far	ADV
admet-1022	183	38	to	to	PART
admet-1022	183	39	propose	propose	VERB
admet-1022	183	40	the	the	DET
admet-1022	183	41	normalization	normalization	NOUN
admet-1022	183	42	of	of	ADP
admet-1022	183	43	mw	mw	NUM
admet-1022	183	44	to	to	ADP
admet-1022	183	45	the	the	DET
admet-1022	183	46	number	number	NOUN
admet-1022	183	47	of	of	ADP
admet-1022	183	48	polar	polar	ADJ
admet-1022	183	49	atoms	atom	NOUN
admet-1022	183	50	[	[	X
admet-1022	183	51	n+o	n+o	NUM
admet-1022	183	52	]	]	X
admet-1022	183	53	.	.	PUNCT
admet-1022	184	1	the	the	DET
admet-1022	184	2	term	term	NOUN
admet-1022	184	3	mw	mw	VERB
admet-1022	184	4	/	/	SYM
admet-1022	184	5	no	no	NOUN
admet-1022	184	6	is	be	AUX
admet-1022	184	7	calculated	calculate	VERB
admet-1022	184	8	according	accord	VERB
admet-1022	184	9	to	to	ADP
admet-1022	184	10	the	the	DET
admet-1022	184	11	expression	expression	NOUN
admet-1022	184	12	mw/(1+[n+o	mw/(1+[n+o	NOUN
admet-1022	184	13	]	]	NOUN
admet-1022	184	14	)	)	PUNCT
admet-1022	184	15	,	,	PUNCT
admet-1022	184	16	where	where	SCONJ
admet-1022	184	17	1	1	NUM
admet-1022	184	18	stands	stand	VERB
admet-1022	184	19	to	to	PART
admet-1022	184	20	avoid	avoid	VERB
admet-1022	184	21	division	division	NOUN
admet-1022	184	22	by	by	ADP
admet-1022	184	23	0	0	NUM
admet-1022	184	24	in	in	ADP
admet-1022	184	25	the	the	DET
admet-1022	184	26	case	case	NOUN
admet-1022	184	27	of	of	ADP
admet-1022	184	28	compounds	compound	NOUN
admet-1022	184	29	that	that	PRON
admet-1022	184	30	lack	lack	VERB
admet-1022	184	31	n	n	NOUN
admet-1022	184	32	and	and	CCONJ
admet-1022	184	33	o	o	NOUN
admet-1022	184	34	atoms	atom	NOUN
admet-1022	184	35	.	.	PUNCT
admet-1022	185	1	considering	consider	VERB
admet-1022	185	2	the	the	DET
admet-1022	185	3	distribution	distribution	NOUN
admet-1022	185	4	of	of	ADP
admet-1022	185	5	mw	mw	PROPN
admet-1022	185	6	/	/	SYM
admet-1022	185	7	no	no	NOUN
admet-1022	185	8	in	in	ADP
admet-1022	185	9	classes	class	NOUN
admet-1022	185	10	1	1	NUM
admet-1022	185	11	and	and	CCONJ
admet-1022	185	12	2	2	NUM
admet-1022	185	13	(	(	PUNCT
admet-1022	185	14	figure	figure	NOUN
admet-1022	185	15	not	not	PART
admet-1022	185	16	shown	show	VERB
admet-1022	185	17	)	)	PUNCT
admet-1022	185	18	,	,	PUNCT
admet-1022	185	19	a	a	DET
admet-1022	185	20	discriminant	discriminant	ADJ
admet-1022	185	21	value	value	NOUN
admet-1022	185	22	of	of	ADP
admet-1022	185	23	50	50	NUM
admet-1022	185	24	is	be	AUX
admet-1022	185	25	set	set	VERB
admet-1022	185	26	to	to	PART
admet-1022	185	27	differentiate	differentiate	VERB
admet-1022	185	28	the	the	DET
admet-1022	185	29	two	two	NUM
admet-1022	185	30	classes	class	NOUN
admet-1022	185	31	.	.	PUNCT
admet-1022	186	1	for	for	ADP
admet-1022	186	2	class	class	NOUN
admet-1022	186	3	1	1	NUM
admet-1022	186	4	,	,	PUNCT
admet-1022	186	5	the	the	DET
admet-1022	186	6	majority	majority	NOUN
admet-1022	186	7	(	(	PUNCT
admet-1022	186	8	72	72	NUM
admet-1022	186	9	%	%	NOUN
admet-1022	186	10	)	)	PUNCT
admet-1022	186	11	of	of	ADP
admet-1022	186	12	drugs	drug	NOUN
admet-1022	186	13	display	display	VERB
admet-1022	186	14	mw	mw	PROPN
admet-1022	186	15	/	/	SYM
admet-1022	186	16	no>50	no>50	ADP
admet-1022	186	17	,	,	PUNCT
admet-1022	186	18	while	while	SCONJ
admet-1022	186	19	the	the	DET
admet-1022	186	20	opposite	opposite	NOUN
admet-1022	186	21	occurs	occur	VERB
admet-1022	186	22	for	for	ADP
admet-1022	186	23	class	class	NOUN
admet-1022	186	24	2	2	NUM
admet-1022	186	25	drugs	drug	NOUN
admet-1022	186	26	,	,	PUNCT
admet-1022	186	27	with	with	ADP
admet-1022	186	28	75	75	NUM
admet-1022	186	29	%	%	NOUN
admet-1022	186	30	showing	show	VERB
admet-1022	186	31	mw	mw	NOUN
admet-1022	186	32	/	/	SYM
admet-1022	186	33	no≤50	no≤50	PROPN
admet-1022	186	34	(	(	PUNCT
admet-1022	186	35	figure	figure	NOUN
admet-1022	186	36	12	12	NUM
admet-1022	186	37	)	)	PUNCT
admet-1022	186	38	.	.	PUNCT
admet-1022	187	1	admet	admet	PROPN
admet-1022	187	2	&	&	CCONJ
admet-1022	187	3	dmpk	dmpk	PROPN
admet-1022	187	4	9(3	9(3	NUM
admet-1022	187	5	)	)	PUNCT
admet-1022	187	6	(	(	PUNCT
admet-1022	187	7	2021	2021	NUM
admet-1022	187	8	)	)	PUNCT
admet-1022	187	9	177	177	NUM
admet-1022	187	10	-	-	SYM
admet-1022	187	11	190	190	NUM
admet-1022	187	12	drug	drug	NOUN
admet-1022	187	13	-	-	PUNCT
admet-1022	187	14	likeness	likeness	NOUN
admet-1022	187	15	and	and	CCONJ
admet-1022	187	16	fraction	fraction	NOUN
admet-1022	187	17	lipophilicity	lipophilicity	PROPN
admet-1022	187	18	index	index	NOUN
admet-1022	187	19	doi	doi	NOUN
admet-1022	187	20	:	:	PUNCT
admet-1022	187	21	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	187	22	187	187	NUM
admet-1022	187	23	figure	figure	NOUN
admet-1022	187	24	10	10	NUM
admet-1022	187	25	.	.	PUNCT
admet-1022	188	1	rule	rule	NOUN
admet-1022	188	2	of	of	ADP
admet-1022	188	3	5	5	NUM
admet-1022	188	4	violations	violation	NOUN
admet-1022	188	5	according	accord	VERB
admet-1022	188	6	to	to	ADP
admet-1022	188	7	fli	fli	NOUN
admet-1022	188	8	levels	level	NOUN
admet-1022	188	9	.	.	PUNCT
admet-1022	189	1	a	a	DET
admet-1022	189	2	:	:	PUNCT
admet-1022	189	3	class	class	NOUN
admet-1022	189	4	1	1	NUM
admet-1022	189	5	,	,	PUNCT
admet-1022	189	6	b	b	NOUN
admet-1022	189	7	:	:	PUNCT
admet-1022	189	8	class	class	NOUN
admet-1022	189	9	1	1	NUM
admet-1022	189	10	subsetdrugs	subsetdrug	NOUN
admet-1022	189	11	inside	inside	ADP
admet-1022	189	12	the	the	DET
admet-1022	189	13	drug	drug	NOUN
admet-1022	189	14	-	-	PUNCT
admet-1022	189	15	like	like	ADJ
admet-1022	189	16	fli	fli	NOUN
admet-1022	189	17	range	range	NOUN
admet-1022	189	18	,	,	PUNCT
admet-1022	189	19	c	c	NOUN
admet-1022	189	20	:	:	PUNCT
admet-1022	189	21	class	class	NOUN
admet-1022	189	22	2	2	NUM
admet-1022	189	23	,	,	PUNCT
admet-1022	189	24	d	d	NOUN
admet-1022	189	25	:	:	PUNCT
admet-1022	189	26	class	class	NOUN
admet-1022	189	27	2	2	NUM
admet-1022	189	28	,	,	PUNCT
admet-1022	189	29	subsetdrugs	subsetdrug	NOUN
admet-1022	189	30	outside	outside	ADP
admet-1022	189	31	the	the	DET
admet-1022	189	32	drug	drug	NOUN
admet-1022	189	33	-	-	PUNCT
admet-1022	189	34	like	like	ADJ
admet-1022	189	35	fli	fli	NOUN
admet-1022	189	36	range	range	NOUN
admet-1022	189	37	.	.	PUNCT
admet-1022	190	1	figure	figure	NOUN
admet-1022	190	2	11	11	NUM
admet-1022	190	3	.	.	PUNCT
admet-1022	191	1	rule	rule	NOUN
admet-1022	191	2	of	of	ADP
admet-1022	191	3	5	5	NUM
admet-1022	191	4	violations	violation	NOUN
admet-1022	191	5	according	accord	VERB
admet-1022	191	6	to	to	ADP
admet-1022	191	7	fli	fli	ADJ
admet-1022	191	8	-	-	PUNCT
admet-1022	191	9	m	m	PROPN
admet-1022	191	10	levels	level	NOUN
admet-1022	191	11	.	.	PUNCT
admet-1022	192	1	a	a	DET
admet-1022	192	2	:	:	PUNCT
admet-1022	192	3	class	class	NOUN
admet-1022	192	4	1	1	NUM
admet-1022	192	5	,	,	PUNCT
admet-1022	192	6	b	b	NOUN
admet-1022	192	7	:	:	PUNCT
admet-1022	192	8	class	class	NOUN
admet-1022	192	9	1	1	NUM
admet-1022	192	10	subsetdrugs	subsetdrug	NOUN
admet-1022	192	11	inside	inside	ADP
admet-1022	192	12	the	the	DET
admet-1022	192	13	drug	drug	NOUN
admet-1022	192	14	-	-	PUNCT
admet-1022	192	15	like	like	ADJ
admet-1022	192	16	fli	fli	ADJ
admet-1022	192	17	-	-	PUNCT
admet-1022	192	18	m	m	NOUN
admet-1022	192	19	range	range	NOUN
admet-1022	192	20	,	,	PUNCT
admet-1022	192	21	c	c	X
admet-1022	192	22	:	:	PUNCT
admet-1022	192	23	class	class	NOUN
admet-1022	192	24	2	2	NUM
admet-1022	192	25	,	,	PUNCT
admet-1022	192	26	d	d	NOUN
admet-1022	192	27	:	:	PUNCT
admet-1022	192	28	class	class	NOUN
admet-1022	192	29	2	2	NUM
admet-1022	192	30	,	,	PUNCT
admet-1022	192	31	subsetdrugs	subsetdrug	NOUN
admet-1022	192	32	outside	outside	ADP
admet-1022	192	33	the	the	DET
admet-1022	192	34	drug	drug	NOUN
admet-1022	192	35	-	-	PUNCT
admet-1022	192	36	like	like	ADJ
admet-1022	192	37	fli	fli	ADJ
admet-1022	192	38	-	-	PUNCT
admet-1022	192	39	m	m	NOUN
admet-1022	192	40	range	range	NOUN
admet-1022	192	41	.	.	PUNCT
admet-1022	193	1	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	193	2	tsantili	tsantili	NOUN
admet-1022	193	3	-	-	PUNCT
admet-1022	193	4	kakoulidou	kakoulidou	NOUN
admet-1022	193	5	and	and	CCONJ
admet-1022	193	6	demopoulos	demopoulos	PROPN
admet-1022	193	7	admet	admet	PROPN
admet-1022	193	8	&	&	CCONJ
admet-1022	193	9	dmpk	dmpk	PROPN
admet-1022	193	10	9(3	9(3	NUM
admet-1022	193	11	)	)	PUNCT
admet-1022	193	12	(	(	PUNCT
admet-1022	193	13	2021	2021	NUM
admet-1022	193	14	)	)	PUNCT
admet-1022	193	15	177	177	NUM
admet-1022	193	16	-	-	SYM
admet-1022	193	17	190	190	NUM
admet-1022	193	18	188	188	NUM
admet-1022	193	19	figure	figure	NOUN
admet-1022	193	20	12	12	NUM
admet-1022	193	21	.	.	PUNCT
admet-1022	194	1	pie	pie	NOUN
admet-1022	194	2	charts	chart	NOUN
admet-1022	194	3	of	of	ADP
admet-1022	194	4	the	the	DET
admet-1022	194	5	distribution	distribution	NOUN
admet-1022	194	6	of	of	ADP
admet-1022	194	7	mw	mw	PROPN
admet-1022	194	8	/	/	SYM
admet-1022	194	9	no	no	NOUN
admet-1022	194	10	for	for	ADP
admet-1022	194	11	class	class	NOUN
admet-1022	194	12	1	1	NUM
admet-1022	194	13	and	and	CCONJ
admet-1022	194	14	class	class	NOUN
admet-1022	194	15	2	2	NUM
admet-1022	194	16	drugs	drug	NOUN
admet-1022	194	17	.	.	PUNCT
admet-1022	195	1	conclusions	conclusion	NOUN
admet-1022	195	2	the	the	DET
admet-1022	195	3	previously	previously	ADV
admet-1022	195	4	established	establish	VERB
admet-1022	195	5	drug	drug	NOUN
admet-1022	195	6	-	-	PUNCT
admet-1022	195	7	like	like	ADJ
admet-1022	195	8	fli	fli	NOUN
admet-1022	195	9	range	range	NOUN
admet-1022	195	10	0	0	NUM
admet-1022	195	11	-	-	SYM
admet-1022	195	12	8	8	NUM
admet-1022	195	13	is	be	AUX
admet-1022	195	14	confirmed	confirm	VERB
admet-1022	195	15	using	use	VERB
admet-1022	195	16	an	an	DET
admet-1022	195	17	extended	extended	ADJ
admet-1022	195	18	dataset	dataset	NOUN
admet-1022	195	19	,	,	PUNCT
admet-1022	195	20	covering	cover	VERB
admet-1022	195	21	93	93	NUM
admet-1022	195	22	%	%	NOUN
admet-1022	195	23	of	of	ADP
admet-1022	195	24	highly	highly	ADV
admet-1022	195	25	to	to	PART
admet-1022	195	26	moderately	moderately	ADV
admet-1022	195	27	absorbed	absorb	VERB
admet-1022	195	28	drugs	drug	NOUN
admet-1022	195	29	.	.	PUNCT
admet-1022	196	1	application	application	NOUN
admet-1022	196	2	of	of	ADP
admet-1022	196	3	three	three	NUM
admet-1022	196	4	different	different	ADJ
admet-1022	196	5	methods	method	NOUN
admet-1022	196	6	,	,	PUNCT
admet-1022	196	7	medchem	medchem	NOUN
admet-1022	196	8	designer	designer	NOUN
admet-1022	196	9	,	,	PUNCT
admet-1022	196	10	clogp	clogp	ADJ
admet-1022	196	11	and	and	CCONJ
admet-1022	196	12	mlogp	mlogp	NOUN
admet-1022	196	13	for	for	ADP
admet-1022	196	14	lipophilicity	lipophilicity	NOUN
admet-1022	196	15	assessment	assessment	NOUN
admet-1022	196	16	in	in	ADP
admet-1022	196	17	fli	fli	PROPN
admet-1022	196	18	generation	generation	NOUN
admet-1022	196	19	,	,	PUNCT
admet-1022	196	20	supported	support	VERB
admet-1022	196	21	the	the	DET
admet-1022	196	22	robustness	robustness	NOUN
admet-1022	196	23	of	of	ADP
admet-1022	196	24	the	the	DET
admet-1022	196	25	results	result	NOUN
admet-1022	196	26	while	while	SCONJ
admet-1022	196	27	showing	show	VERB
admet-1022	196	28	that	that	SCONJ
admet-1022	196	29	the	the	DET
admet-1022	196	30	metric	metric	NOUN
admet-1022	196	31	is	be	AUX
admet-1022	196	32	overall	overall	ADV
admet-1022	196	33	independent	independent	ADJ
admet-1022	196	34	of	of	ADP
admet-1022	196	35	log	log	NOUN
admet-1022	196	36	p	p	NOUN
admet-1022	196	37	calculation	calculation	NOUN
admet-1022	196	38	system	system	NOUN
admet-1022	196	39	.	.	PUNCT
admet-1022	197	1	however	however	ADV
admet-1022	197	2	,	,	PUNCT
admet-1022	197	3	the	the	DET
admet-1022	197	4	fli	fli	NOUN
admet-1022	197	5	-	-	PUNCT
admet-1022	197	6	m	m	PROPN
admet-1022	197	7	values	value	NOUN
admet-1022	197	8	generated	generate	VERB
admet-1022	197	9	by	by	ADP
admet-1022	197	10	mlogp	mlogp	NOUN
admet-1022	197	11	,	,	PUNCT
admet-1022	197	12	which	which	PRON
admet-1022	197	13	is	be	AUX
admet-1022	197	14	associated	associate	VERB
admet-1022	197	15	with	with	ADP
admet-1022	197	16	a	a	DET
admet-1022	197	17	lower	low	ADJ
admet-1022	197	18	drug	drug	NOUN
admet-1022	197	19	-	-	PUNCT
admet-1022	197	20	like	like	ADJ
admet-1022	197	21	upper	upper	ADJ
admet-1022	197	22	limit	limit	NOUN
admet-1022	197	23	,	,	PUNCT
admet-1022	197	24	shape	shape	VERB
admet-1022	197	25	a	a	DET
admet-1022	197	26	narrower	narrow	ADJ
admet-1022	197	27	drug	drug	NOUN
admet-1022	197	28	-	-	PUNCT
admet-1022	197	29	like	like	ADJ
admet-1022	197	30	range	range	NOUN
admet-1022	197	31	between	between	ADP
admet-1022	197	32	0	0	NUM
admet-1022	197	33	-	-	SYM
admet-1022	197	34	7	7	NUM
admet-1022	197	35	,	,	PUNCT
admet-1022	197	36	covering	cover	VERB
admet-1022	197	37	91	91	NUM
admet-1022	197	38	%	%	NOUN
admet-1022	197	39	of	of	ADP
admet-1022	197	40	class	class	NOUN
admet-1022	197	41	1	1	NUM
admet-1022	197	42	drugs	drug	NOUN
admet-1022	197	43	.	.	PUNCT
admet-1022	198	1	fli	fli	PROPN
admet-1022	198	2	tolerates	tolerate	VERB
admet-1022	198	3	higher	high	ADJ
admet-1022	198	4	log	log	VERB
admet-1022	198	5	p	p	NOUN
admet-1022	198	6	values	value	NOUN
admet-1022	198	7	for	for	ADP
admet-1022	198	8	drugs	drug	NOUN
admet-1022	198	9	,	,	PUNCT
admet-1022	198	10	provided	provide	VERB
admet-1022	198	11	that	that	SCONJ
admet-1022	198	12	ionization	ionization	NOUN
admet-1022	198	13	is	be	AUX
admet-1022	198	14	limited	limited	ADJ
admet-1022	198	15	.	.	PUNCT
admet-1022	199	1	it	it	PRON
admet-1022	199	2	offers	offer	VERB
admet-1022	199	3	the	the	DET
admet-1022	199	4	option	option	NOUN
admet-1022	199	5	to	to	PART
admet-1022	199	6	explore	explore	VERB
admet-1022	199	7	a	a	DET
admet-1022	199	8	wider	wide	ADJ
admet-1022	199	9	chemical	chemical	NOUN
admet-1022	199	10	space	space	NOUN
admet-1022	199	11	for	for	ADP
admet-1022	199	12	drug	drug	NOUN
admet-1022	199	13	discovery	discovery	NOUN
admet-1022	199	14	,	,	PUNCT
admet-1022	199	15	notwithstanding	notwithstanding	ADP
admet-1022	199	16	the	the	DET
admet-1022	199	17	disadvantages	disadvantage	NOUN
admet-1022	199	18	of	of	ADP
admet-1022	199	19	high	high	ADJ
admet-1022	199	20	lipophilicity	lipophilicity	NOUN
admet-1022	199	21	regarding	regard	VERB
admet-1022	199	22	other	other	ADJ
admet-1022	199	23	issues	issue	NOUN
admet-1022	199	24	,	,	PUNCT
admet-1022	199	25	like	like	ADP
admet-1022	199	26	promiscuity	promiscuity	NOUN
admet-1022	199	27	,	,	PUNCT
admet-1022	199	28	extensive	extensive	ADJ
admet-1022	199	29	metabolism	metabolism	NOUN
admet-1022	199	30	or	or	CCONJ
admet-1022	199	31	toxicity	toxicity	NOUN
admet-1022	199	32	.	.	PUNCT
admet-1022	200	1	on	on	ADP
admet-1022	200	2	the	the	DET
admet-1022	200	3	other	other	ADJ
admet-1022	200	4	hand	hand	NOUN
admet-1022	200	5	,	,	PUNCT
admet-1022	200	6	negative	negative	ADJ
admet-1022	200	7	fli	fli	ADJ
admet-1022	200	8	values	value	NOUN
admet-1022	200	9	minimize	minimize	VERB
admet-1022	200	10	the	the	DET
admet-1022	200	11	chances	chance	NOUN
admet-1022	200	12	for	for	ADP
admet-1022	200	13	oral	oral	ADJ
admet-1022	200	14	absorption	absorption	NOUN
admet-1022	200	15	.	.	PUNCT
admet-1022	201	1	the	the	DET
admet-1022	201	2	merit	merit	NOUN
admet-1022	201	3	of	of	ADP
admet-1022	201	4	fli	fli	NOUN
admet-1022	201	5	lies	lie	VERB
admet-1022	201	6	in	in	ADP
admet-1022	201	7	the	the	DET
admet-1022	201	8	fact	fact	NOUN
admet-1022	201	9	that	that	SCONJ
admet-1022	201	10	it	it	PRON
admet-1022	201	11	is	be	AUX
admet-1022	201	12	a	a	DET
admet-1022	201	13	combined	combined	ADJ
admet-1022	201	14	metric	metric	NOUN
admet-1022	201	15	of	of	ADP
admet-1022	201	16	lipophilicity	lipophilicity	NOUN
admet-1022	201	17	and	and	CCONJ
admet-1022	201	18	ionization	ionization	NOUN
admet-1022	201	19	and	and	CCONJ
admet-1022	201	20	provides	provide	VERB
admet-1022	201	21	more	more	ADJ
admet-1022	201	22	information	information	NOUN
admet-1022	201	23	on	on	ADP
admet-1022	201	24	drug	drug	NOUN
admet-1022	201	25	characteristics	characteristic	NOUN
admet-1022	201	26	while	while	SCONJ
admet-1022	201	27	‘	'	PUNCT
admet-1022	201	28	softening	soften	VERB
admet-1022	201	29	’	'	PUNCT
admet-1022	201	30	the	the	DET
admet-1022	201	31	hard	hard	ADJ
admet-1022	201	32	limits	limit	NOUN
admet-1022	201	33	.	.	PUNCT
admet-1022	202	1	we	we	PRON
admet-1022	202	2	,	,	PUNCT
admet-1022	202	3	therefore	therefore	ADV
admet-1022	202	4	,	,	PUNCT
admet-1022	202	5	suggest	suggest	VERB
admet-1022	202	6	that	that	SCONJ
admet-1022	202	7	a	a	DET
admet-1022	202	8	combination	combination	NOUN
admet-1022	202	9	of	of	ADP
admet-1022	202	10	metrics	metric	NOUN
admet-1022	202	11	may	may	AUX
admet-1022	202	12	be	be	AUX
admet-1022	202	13	preferable	preferable	ADJ
admet-1022	202	14	to	to	ADP
admet-1022	202	15	single	single	ADJ
admet-1022	202	16	properties	property	NOUN
admet-1022	202	17	.	.	PUNCT
admet-1022	203	1	in	in	ADP
admet-1022	203	2	this	this	DET
admet-1022	203	3	sense	sense	NOUN
admet-1022	203	4	and	and	CCONJ
admet-1022	203	5	considering	consider	VERB
admet-1022	203	6	the	the	DET
admet-1022	203	7	crucial	crucial	ADJ
admet-1022	203	8	two	two	NUM
admet-1022	203	9	-	-	PUNCT
admet-1022	203	10	fold	fold	ADJ
admet-1022	203	11	violation	violation	NOUN
admet-1022	203	12	including	include	VERB
admet-1022	203	13	mw	mw	PROPN
admet-1022	203	14	and	and	CCONJ
admet-1022	203	15	[	[	X
admet-1022	203	16	n+o	n+o	NUM
admet-1022	203	17	]	]	X
admet-1022	203	18	,	,	PUNCT
admet-1022	203	19	we	we	PRON
admet-1022	203	20	propose	propose	VERB
admet-1022	203	21	a	a	DET
admet-1022	203	22	combined	combine	VERB
admet-1022	203	23	metric	metric	NOUN
admet-1022	203	24	of	of	ADP
admet-1022	203	25	mw	mw	NOUN
admet-1022	203	26	and	and	CCONJ
admet-1022	203	27	the	the	DET
admet-1022	203	28	number	number	NOUN
admet-1022	203	29	of	of	ADP
admet-1022	203	30	polar	polar	ADJ
admet-1022	203	31	atoms	atom	NOUN
admet-1022	203	32	[	[	X
admet-1022	203	33	mw	mw	X
admet-1022	203	34	/	/	SYM
admet-1022	203	35	no	no	NOUN
admet-1022	203	36	]	]	PUNCT
admet-1022	203	37	to	to	PART
admet-1022	203	38	account	account	VERB
admet-1022	203	39	for	for	ADP
admet-1022	203	40	both	both	DET
admet-1022	203	41	size	size	NOUN
admet-1022	203	42	and	and	CCONJ
admet-1022	203	43	polarity	polarity	NOUN
admet-1022	203	44	.	.	PUNCT
admet-1022	204	1	exploration	exploration	NOUN
admet-1022	204	2	of	of	ADP
admet-1022	204	3	mw	mw	PROPN
admet-1022	204	4	/	/	SYM
admet-1022	204	5	no	no	PROPN
admet-1022	204	6	will	will	AUX
admet-1022	204	7	follow	follow	VERB
admet-1022	204	8	in	in	ADP
admet-1022	204	9	future	future	ADJ
admet-1022	204	10	investigations	investigation	NOUN
admet-1022	204	11	.	.	PUNCT
admet-1022	205	1	conflict	conflict	NOUN
admet-1022	205	2	of	of	ADP
admet-1022	205	3	interest	interest	NOUN
admet-1022	205	4	:	:	PUNCT
admet-1022	205	5	authors	author	NOUN
admet-1022	205	6	claim	claim	VERB
admet-1022	205	7	no	no	DET
admet-1022	205	8	conflict	conflict	NOUN
admet-1022	205	9	of	of	ADP
admet-1022	205	10	interest	interest	NOUN
admet-1022	205	11	.	.	PUNCT
admet-1022	206	1	references	reference	NOUN
admet-1022	206	2	[	[	X
admet-1022	206	3	1	1	NUM
admet-1022	206	4	]	]	X
admet-1022	206	5	p.d	p.d	PROPN
admet-1022	206	6	.	.	PROPN
admet-1022	206	7	leeson	leeson	PROPN
admet-1022	206	8	,	,	PUNCT
admet-1022	206	9	b.	b.	PROPN
admet-1022	206	10	springthorpe	springthorpe	PROPN
admet-1022	206	11	.	.	PUNCT
admet-1022	207	1	the	the	DET
admet-1022	207	2	influence	influence	NOUN
admet-1022	207	3	of	of	ADP
admet-1022	207	4	drug	drug	NOUN
admet-1022	207	5	-	-	PUNCT
admet-1022	207	6	like	like	ADJ
admet-1022	207	7	concepts	concept	NOUN
admet-1022	207	8	on	on	ADP
admet-1022	207	9	decision	decision	NOUN
admet-1022	207	10	-	-	PUNCT
admet-1022	207	11	making	making	NOUN
admet-1022	207	12	in	in	ADP
admet-1022	207	13	medicinal	medicinal	ADJ
admet-1022	207	14	chemistry	chemistry	NOUN
admet-1022	207	15	.	.	PUNCT
admet-1022	208	1	nature	nature	NOUN
admet-1022	208	2	reviews	review	VERB
admet-1022	208	3	drug	drug	NOUN
admet-1022	208	4	discovery	discovery	NOUN
admet-1022	208	5	11	11	NUM
admet-1022	208	6	(	(	PUNCT
admet-1022	208	7	2007	2007	NUM
admet-1022	208	8	)	)	PUNCT
admet-1022	208	9	881	881	NUM
admet-1022	208	10	-	-	SYM
admet-1022	208	11	90	90	NUM
admet-1022	208	12	.	.	PUNCT
admet-1022	208	13	https://doi.org/10.1038/nrd2445	https://doi.org/10.1038/nrd2445	NOUN
admet-1022	208	14	.	.	PUNCT
admet-1022	209	1	[	[	X
admet-1022	209	2	2	2	NUM
admet-1022	209	3	]	]	PUNCT
admet-1022	209	4	i.	i.	NOUN
admet-1022	209	5	yusof	yusof	PROPN
admet-1022	209	6	,	,	PUNCT
admet-1022	209	7	m.d	m.d	PROPN
admet-1022	209	8	.	.	PROPN
admet-1022	209	9	segall	segall	PROPN
admet-1022	209	10	.	.	PUNCT
admet-1022	210	1	considering	consider	VERB
admet-1022	210	2	the	the	DET
admet-1022	210	3	impact	impact	NOUN
admet-1022	210	4	drug	drug	NOUN
admet-1022	210	5	-	-	PUNCT
admet-1022	210	6	like	like	ADJ
admet-1022	210	7	properties	property	NOUN
admet-1022	210	8	have	have	VERB
admet-1022	210	9	on	on	ADP
admet-1022	210	10	the	the	DET
admet-1022	210	11	chance	chance	NOUN
admet-1022	210	12	of	of	ADP
admet-1022	210	13	success	success	NOUN
admet-1022	210	14	.	.	PUNCT
admet-1022	211	1	drug	drug	NOUN
admet-1022	211	2	discovery	discovery	PROPN
admet-1022	211	3	today	today	NOUN
admet-1022	211	4	18	18	NUM
admet-1022	211	5	(	(	PUNCT
admet-1022	211	6	2013	2013	NUM
admet-1022	211	7	)	)	PUNCT
admet-1022	211	8	659	659	NUM
admet-1022	211	9	-	-	SYM
admet-1022	211	10	666	666	NUM
admet-1022	211	11	.	.	PUNCT
admet-1022	212	1	https://doi.org/10.1016/j.drudis.2013.02.008	https://doi.org/10.1016/j.drudis.2013.02.008	PROPN
admet-1022	212	2	.	.	PUNCT
admet-1022	213	1	[	[	X
admet-1022	213	2	3	3	NUM
admet-1022	213	3	]	]	PUNCT
admet-1022	213	4	m.	m.	NOUN
admet-1022	213	5	wenlock	wenlock	PROPN
admet-1022	213	6	,	,	PUNCT
admet-1022	213	7	r.p	r.p	PROPN
admet-1022	213	8	.	.	PROPN
admet-1022	213	9	austin	austin	PROPN
admet-1022	213	10	,	,	PUNCT
admet-1022	213	11	p.	p.	PROPN
admet-1022	213	12	barton	barton	PROPN
admet-1022	213	13	,	,	PUNCT
admet-1022	213	14	a.m.	a.m.	PROPN
admet-1022	213	15	davis	davis	PROPN
admet-1022	213	16	,	,	PUNCT
admet-1022	213	17	p.d	p.d	PROPN
admet-1022	213	18	.	.	PROPN
admet-1022	213	19	leeson	leeson	PROPN
admet-1022	213	20	.	.	PUNCT
admet-1022	214	1	a	a	DET
admet-1022	214	2	comparison	comparison	NOUN
admet-1022	214	3	of	of	ADP
admet-1022	214	4	physiochemical	physiochemical	ADJ
admet-1022	214	5	property	property	NOUN
admet-1022	214	6	profiles	profile	NOUN
admet-1022	214	7	of	of	ADP
admet-1022	214	8	development	development	NOUN
admet-1022	214	9	and	and	CCONJ
admet-1022	214	10	marketed	market	VERB
admet-1022	214	11	oral	oral	ADJ
admet-1022	214	12	drugs	drug	NOUN
admet-1022	214	13	.	.	PUNCT
admet-1022	215	1	journal	journal	NOUN
admet-1022	215	2	of	of	ADP
admet-1022	215	3	medicinal	medicinal	ADJ
admet-1022	215	4	chemistry	chemistry	NOUN
admet-1022	215	5	46	46	NUM
admet-1022	215	6	(	(	PUNCT
admet-1022	215	7	2003	2003	NUM
admet-1022	215	8	)	)	PUNCT
admet-1022	215	9	1250–1256	1250–1256	NUM
admet-1022	215	10	.	.	PUNCT
admet-1022	216	1	https://doi.org/10.1021/jm021053p	https://doi.org/10.1021/jm021053p	PROPN
admet-1022	216	2	.	.	PUNCT
admet-1022	217	1	[	[	X
admet-1022	217	2	4	4	NUM
admet-1022	217	3	]	]	X
admet-1022	217	4	m.m	m.m	PROPN
admet-1022	217	5	.	.	PROPN
admet-1022	217	6	hann	hann	PROPN
admet-1022	217	7	.	.	PUNCT
admet-1022	218	1	molecular	molecular	ADJ
admet-1022	218	2	obesity	obesity	NOUN
admet-1022	218	3	,	,	PUNCT
admet-1022	218	4	potency	potency	NOUN
admet-1022	218	5	and	and	CCONJ
admet-1022	218	6	other	other	ADJ
admet-1022	218	7	addictions	addiction	NOUN
admet-1022	218	8	in	in	ADP
admet-1022	218	9	drug	drug	NOUN
admet-1022	218	10	discovery	discovery	NOUN
admet-1022	218	11	.	.	PUNCT
admet-1022	219	1	medicinal	medicinal	ADJ
admet-1022	219	2	chemistry	chemistry	NOUN
admet-1022	219	3	communications	communication	NOUN
admet-1022	219	4	2	2	NUM
admet-1022	219	5	(	(	PUNCT
admet-1022	219	6	2011	2011	NUM
admet-1022	219	7	)	)	PUNCT
admet-1022	219	8	349	349	NUM
admet-1022	219	9	-	-	SYM
admet-1022	219	10	355	355	NUM
admet-1022	219	11	.	.	PUNCT
admet-1022	220	1	https://doi.org/10.1039/c1md00017a	https://doi.org/10.1039/c1md00017a	PROPN
admet-1022	220	2	.	.	PUNCT
admet-1022	221	1	[	[	X
admet-1022	221	2	5	5	NUM
admet-1022	221	3	]	]	PUNCT
admet-1022	221	4	s.	s.	PROPN
admet-1022	221	5	mignani	mignani	PROPN
admet-1022	221	6	,	,	PUNCT
admet-1022	221	7	s.	s.	PROPN
admet-1022	221	8	huber	huber	PROPN
admet-1022	221	9	,	,	PUNCT
admet-1022	221	10	h.	h.	PROPN
admet-1022	221	11	tomás	tomás	PROPN
admet-1022	221	12	j.	j.	PROPN
admet-1022	221	13	rodrigues	rodrigues	PROPN
admet-1022	221	14	,	,	PUNCT
admet-1022	221	15	j.p	j.p	PROPN
admet-1022	221	16	.	.	PROPN
admet-1022	221	17	majoral	majoral	PROPN
admet-1022	221	18	.	.	PUNCT
admet-1022	222	1	compound	compound	VERB
admet-1022	222	2	high	high	ADJ
admet-1022	222	3	-	-	PUNCT
admet-1022	222	4	quality	quality	NOUN
admet-1022	222	5	criteria	criterion	NOUN
admet-1022	222	6	:	:	PUNCT
admet-1022	222	7	a	a	DET
admet-1022	222	8	new	new	ADJ
admet-1022	222	9	vision	vision	NOUN
admet-1022	222	10	to	to	PART
admet-1022	222	11	guide	guide	VERB
admet-1022	222	12	the	the	DET
admet-1022	222	13	development	development	NOUN
admet-1022	222	14	of	of	ADP
admet-1022	222	15	drugs	drug	NOUN
admet-1022	222	16	,	,	PUNCT
admet-1022	222	17	current	current	ADJ
admet-1022	222	18	situation	situation	NOUN
admet-1022	222	19	.	.	PUNCT
admet-1022	223	1	drug	drug	NOUN
admet-1022	223	2	discovery	discovery	PROPN
admet-1022	223	3	today	today	NOUN
admet-1022	223	4	21	21	NUM
admet-1022	223	5	(	(	PUNCT
admet-1022	223	6	2016	2016	NUM
admet-1022	223	7	)	)	PUNCT
admet-1022	223	8	573	573	NUM
admet-1022	223	9	-	-	SYM
admet-1022	223	10	584	584	NUM
admet-1022	223	11	.	.	PUNCT
admet-1022	224	1	https://doi.org/10.1016/j.drudis.2016.01.005	https://doi.org/10.1016/j.drudis.2016.01.005	PROPN
admet-1022	224	2	.	.	PUNCT
admet-1022	225	1	[	[	X
admet-1022	225	2	6	6	NUM
admet-1022	225	3	]	]	PUNCT
admet-1022	225	4	s.	s.	PROPN
admet-1022	225	5	wang	wang	PROPN
admet-1022	225	6	,	,	PUNCT
admet-1022	225	7	g.	g.	PROPN
admet-1022	225	8	dong	dong	PROPN
admet-1022	225	9	,	,	PUNCT
admet-1022	225	10	c.	c.	PROPN
admet-1022	225	11	sheng	sheng	PROPN
admet-1022	225	12	.	.	PUNCT
admet-1022	226	1	structural	structural	ADJ
admet-1022	226	2	simplification	simplification	NOUN
admet-1022	226	3	:	:	PUNCT
admet-1022	226	4	an	an	DET
admet-1022	226	5	efficient	efficient	ADJ
admet-1022	226	6	strategy	strategy	NOUN
admet-1022	226	7	in	in	ADP
admet-1022	226	8	lead	lead	ADJ
admet-1022	226	9	optimization	optimization	NOUN
admet-1022	226	10	.	.	PUNCT
admet-1022	227	1	acta	acta	PROPN
admet-1022	227	2	pharmaceutica	pharmaceutica	PROPN
admet-1022	227	3	sinica	sinica	PROPN
admet-1022	227	4	b	b	PROPN
admet-1022	227	5	9	9	NUM
admet-1022	227	6	(	(	PUNCT
admet-1022	227	7	2019	2019	NUM
admet-1022	227	8	)	)	PUNCT
admet-1022	227	9	880	880	NUM
admet-1022	227	10	-	-	PUNCT
admet-1022	227	11	901	901	NUM
admet-1022	227	12	https://doi.org/10.1016/j.apsb.2019.05.004	https://doi.org/10.1016/j.apsb.2019.05.004	NOUN
admet-1022	227	13	.	.	PUNCT
admet-1022	228	1	https://doi.org/10.1038/nrd2445	https://doi.org/10.1038/nrd2445	PROPN
admet-1022	228	2	https://doi.org/10.1016/j.drudis.2013.02.008	https://doi.org/10.1016/j.drudis.2013.02.008	PROPN
admet-1022	228	3	https://doi.org/10.1021/jm021053p	https://doi.org/10.1021/jm021053p	VERB
admet-1022	228	4	https://doi.org/10.1039/c1md00017a	https://doi.org/10.1039/c1md00017a	PUNCT
admet-1022	228	5	https://doi.org/10.1016/j.drudis.2016.01.005	https://doi.org/10.1016/j.drudis.2016.01.005	PROPN
admet-1022	228	6	https://doi.org/10.1016/j.apsb.2019.05.004	https://doi.org/10.1016/j.apsb.2019.05.004	PROPN
admet-1022	228	7	admet	admet	PROPN
admet-1022	228	8	&	&	CCONJ
admet-1022	228	9	dmpk	dmpk	PROPN
admet-1022	228	10	9(3	9(3	NUM
admet-1022	228	11	)	)	PUNCT
admet-1022	228	12	(	(	PUNCT
admet-1022	228	13	2021	2021	NUM
admet-1022	228	14	)	)	PUNCT
admet-1022	228	15	177	177	NUM
admet-1022	228	16	-	-	SYM
admet-1022	228	17	190	190	NUM
admet-1022	228	18	drug	drug	NOUN
admet-1022	228	19	-	-	PUNCT
admet-1022	228	20	likeness	likeness	NOUN
admet-1022	228	21	and	and	CCONJ
admet-1022	228	22	fraction	fraction	NOUN
admet-1022	228	23	lipophilicity	lipophilicity	PROPN
admet-1022	228	24	index	index	NOUN
admet-1022	228	25	doi	doi	NOUN
admet-1022	228	26	:	:	PUNCT
admet-1022	228	27	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	NOUN
admet-1022	228	28	189	189	NUM
admet-1022	228	29	[	[	X
admet-1022	228	30	7	7	NUM
admet-1022	228	31	]	]	X
admet-1022	228	32	c.	c.	PROPN
admet-1022	228	33	hansch	hansch	PROPN
admet-1022	228	34	,	,	PUNCT
admet-1022	228	35	j.	j.	PROPN
admet-1022	228	36	p.	p.	PROPN
admet-1022	228	37	bjorkroth	bjorkroth	PROPN
admet-1022	228	38	,	,	PUNCT
admet-1022	229	1	a.	a.	PROPN
admet-1022	229	2	leo	leo	PROPN
admet-1022	229	3	.	.	PROPN
admet-1022	229	4	hydrophobicity	hydrophobicity	PROPN
admet-1022	229	5	and	and	CCONJ
admet-1022	229	6	central	central	ADJ
admet-1022	229	7	nervous	nervous	ADJ
admet-1022	229	8	system	system	NOUN
admet-1022	229	9	agents	agent	NOUN
admet-1022	229	10	:	:	PUNCT
admet-1022	229	11	on	on	ADP
admet-1022	229	12	the	the	DET
admet-1022	229	13	principle	principle	NOUN
admet-1022	229	14	of	of	ADP
admet-1022	229	15	minimal	minimal	ADJ
admet-1022	229	16	hydrophobicity	hydrophobicity	NOUN
admet-1022	229	17	in	in	ADP
admet-1022	229	18	drug	drug	NOUN
admet-1022	229	19	design	design	NOUN
admet-1022	229	20	.	.	PUNCT
admet-1022	230	1	journal	journal	NOUN
admet-1022	230	2	of	of	ADP
admet-1022	230	3	pharmaceutical	pharmaceutical	PROPN
admet-1022	230	4	sciences	science	NOUN
admet-1022	230	5	76	76	NUM
admet-1022	230	6	(	(	PUNCT
admet-1022	230	7	1987	1987	NUM
admet-1022	230	8	)	)	PUNCT
admet-1022	230	9	66	66	NUM
admet-1022	230	10	-	-	SYM
admet-1022	230	11	687	687	NUM
admet-1022	230	12	.	.	PUNCT
admet-1022	231	1	https://doi.org/10.1002/jps.2600760902	https://doi.org/10.1002/jps.2600760902	VERB
admet-1022	231	2	.	.	PUNCT
admet-1022	232	1	[	[	X
admet-1022	232	2	8	8	NUM
admet-1022	232	3	]	]	X
admet-1022	232	4	c.a	c.a	PROPN
admet-1022	232	5	.	.	PROPN
admet-1022	232	6	lipinski	lipinski	PROPN
admet-1022	232	7	,	,	PUNCT
admet-1022	232	8	f.	f.	PROPN
admet-1022	232	9	lombardo	lombardo	PROPN
admet-1022	232	10	,	,	PUNCT
admet-1022	232	11	b.w	b.w	PROPN
admet-1022	232	12	.	.	PROPN
admet-1022	232	13	dominy	dominy	PROPN
admet-1022	232	14	,	,	PUNCT
admet-1022	232	15	p.j	p.j	PROPN
admet-1022	232	16	.	.	PROPN
admet-1022	232	17	feeney	feeney	PROPN
admet-1022	232	18	.	.	PUNCT
admet-1022	233	1	experimental	experimental	ADJ
admet-1022	233	2	and	and	CCONJ
admet-1022	233	3	computational	computational	ADJ
admet-1022	233	4	approaches	approach	NOUN
admet-1022	233	5	to	to	PART
admet-1022	233	6	estimate	estimate	VERB
admet-1022	233	7	solubility	solubility	NOUN
admet-1022	233	8	and	and	CCONJ
admet-1022	233	9	permeability	permeability	NOUN
admet-1022	233	10	in	in	ADP
admet-1022	233	11	drug	drug	NOUN
admet-1022	233	12	discovery	discovery	NOUN
admet-1022	233	13	and	and	CCONJ
admet-1022	233	14	development	development	NOUN
admet-1022	233	15	settings	setting	NOUN
admet-1022	233	16	.	.	PUNCT
admet-1022	234	1	advanced	advanced	ADJ
admet-1022	234	2	drug	drug	NOUN
admet-1022	234	3	delivery	delivery	NOUN
admet-1022	234	4	reviews	review	VERB
admet-1022	234	5	46	46	NUM
admet-1022	234	6	(	(	PUNCT
admet-1022	234	7	1997	1997	NUM
admet-1022	234	8	)	)	PUNCT
admet-1022	234	9	3	3	NUM
admet-1022	234	10	-	-	SYM
admet-1022	234	11	26	26	NUM
admet-1022	234	12	.	.	PUNCT
admet-1022	235	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	ADJ
admet-1022	235	2	.	.	PUNCT
admet-1022	236	1	[	[	X
admet-1022	236	2	9	9	NUM
admet-1022	236	3	]	]	X
admet-1022	236	4	d.f	d.f	PROPN
admet-1022	236	5	.	.	PROPN
admet-1022	236	6	veber	veber	PROPN
admet-1022	236	7	,	,	PUNCT
admet-1022	236	8	s.r	s.r	PROPN
admet-1022	236	9	.	.	PROPN
admet-1022	236	10	johnson	johnson	PROPN
admet-1022	236	11	,	,	PUNCT
admet-1022	236	12	h.-y	h.-y	NOUN
admet-1022	236	13	.	.	PUNCT
admet-1022	237	1	cheng	cheng	PROPN
admet-1022	237	2	,	,	PUNCT
admet-1022	237	3	b.r	b.r	PROPN
admet-1022	237	4	.	.	PROPN
admet-1022	237	5	smith	smith	PROPN
admet-1022	237	6	,	,	PUNCT
admet-1022	237	7	k.w.ward	k.w.ward	PROPN
admet-1022	237	8	,	,	PUNCT
admet-1022	237	9	k.d	k.d	PROPN
admet-1022	237	10	.	.	PROPN
admet-1022	237	11	kopple	kopple	PROPN
admet-1022	237	12	.	.	PUNCT
admet-1022	238	1	molecular	molecular	ADJ
admet-1022	238	2	properties	property	NOUN
admet-1022	238	3	that	that	PRON
admet-1022	238	4	influence	influence	VERB
admet-1022	238	5	the	the	DET
admet-1022	238	6	oral	oral	ADJ
admet-1022	238	7	bioavailability	bioavailability	NOUN
admet-1022	238	8	of	of	ADP
admet-1022	238	9	drug	drug	NOUN
admet-1022	238	10	candidates	candidate	NOUN
admet-1022	238	11	.	.	PUNCT
admet-1022	239	1	journal	journal	NOUN
admet-1022	239	2	of	of	ADP
admet-1022	239	3	medicinal	medicinal	ADJ
admet-1022	239	4	chemistry	chemistry	NOUN
admet-1022	239	5	45	45	NUM
admet-1022	239	6	(	(	PUNCT
admet-1022	239	7	2002	2002	NUM
admet-1022	239	8	)	)	PUNCT
admet-1022	239	9	26152623	26152623	NUM
admet-1022	239	10	.	.	PUNCT
admet-1022	240	1	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	NOUN
admet-1022	240	2	.	.	PUNCT
admet-1022	241	1	[	[	X
admet-1022	241	2	10	10	NUM
admet-1022	241	3	]	]	X
admet-1022	241	4	t.i	t.i	PROPN
admet-1022	241	5	.	.	PROPN
admet-1022	241	6	oprea	oprea	PROPN
admet-1022	241	7	.	.	PUNCT
admet-1022	242	1	current	current	ADJ
admet-1022	242	2	trends	trend	NOUN
admet-1022	242	3	in	in	ADP
admet-1022	242	4	lead	lead	ADJ
admet-1022	242	5	discovery	discovery	NOUN
admet-1022	242	6	:	:	PUNCT
admet-1022	242	7	are	be	AUX
admet-1022	242	8	we	we	PRON
admet-1022	242	9	looking	look	VERB
admet-1022	242	10	for	for	ADP
admet-1022	242	11	the	the	DET
admet-1022	242	12	appropriate	appropriate	ADJ
admet-1022	242	13	properties	property	NOUN
admet-1022	242	14	?	?	PUNCT
admet-1022	243	1	journal	journal	NOUN
admet-1022	243	2	of	of	ADP
admet-1022	243	3	computer	computer	NOUN
admet-1022	243	4	-	-	PUNCT
admet-1022	243	5	aided	aid	VERB
admet-1022	243	6	molecular	molecular	ADJ
admet-1022	243	7	design	design	NOUN
admet-1022	243	8	16	16	NUM
admet-1022	243	9	(	(	PUNCT
admet-1022	243	10	2002	2002	NUM
admet-1022	243	11	)	)	PUNCT
admet-1022	243	12	325	325	NUM
admet-1022	243	13	-	-	SYM
admet-1022	243	14	334	334	NUM
admet-1022	243	15	.	.	PUNCT
admet-1022	244	1	https://doi.org/10.1023/a:1020877402759	https://doi.org/10.1023/a:1020877402759	NOUN
admet-1022	244	2	.	.	PUNCT
admet-1022	245	1	[	[	X
admet-1022	245	2	11	11	NUM
admet-1022	245	3	]	]	X
admet-1022	245	4	t.j	t.j	PROPN
admet-1022	245	5	.	.	PROPN
admet-1022	245	6	ritchie	ritchie	PROPN
admet-1022	245	7	,	,	PUNCT
admet-1022	245	8	s.	s.	PROPN
admet-1022	245	9	j.	j.	PROPN
admet-1022	245	10	f.	f.	PROPN
admet-1022	245	11	macdonald	macdonald	PROPN
admet-1022	245	12	.	.	PUNCT
admet-1022	246	1	how	how	SCONJ
admet-1022	246	2	drug	drug	NOUN
admet-1022	246	3	-	-	PUNCT
admet-1022	246	4	like	like	NOUN
admet-1022	246	5	are	be	AUX
admet-1022	246	6	'	'	PUNCT
admet-1022	246	7	ugly	ugly	ADJ
admet-1022	246	8	'	'	PUNCT
admet-1022	246	9	drugs	drug	NOUN
admet-1022	246	10	:	:	PUNCT
admet-1022	246	11	do	do	AUX
admet-1022	246	12	drug	drug	NOUN
admet-1022	246	13	-	-	PUNCT
admet-1022	246	14	likeness	likeness	NOUN
admet-1022	246	15	metrics	metric	NOUN
admet-1022	246	16	predict	predict	VERB
admet-1022	246	17	adme	adme	NOUN
admet-1022	246	18	behaviour	behaviour	NOUN
admet-1022	246	19	in	in	ADP
admet-1022	246	20	humans	human	NOUN
admet-1022	246	21	?	?	PUNCT
admet-1022	247	1	drug	drug	NOUN
admet-1022	247	2	discovery	discovery	PROPN
admet-1022	247	3	today	today	NOUN
admet-1022	247	4	19	19	NUM
admet-1022	247	5	(	(	PUNCT
admet-1022	247	6	2014	2014	NUM
admet-1022	247	7	)	)	PUNCT
admet-1022	247	8	489	489	NUM
admet-1022	247	9	-	-	SYM
admet-1022	247	10	495	495	NUM
admet-1022	247	11	.	.	PUNCT
admet-1022	248	1	https://doi.org/10.1016/j.drudis.2014.01.007	https://doi.org/10.1016/j.drudis.2014.01.007	NOUN
admet-1022	248	2	.	.	PUNCT
admet-1022	249	1	[	[	X
admet-1022	249	2	12	12	NUM
admet-1022	249	3	]	]	X
admet-1022	249	4	s.	s.	PROPN
admet-1022	249	5	pathania	pathania	PROPN
admet-1022	249	6	,	,	PUNCT
admet-1022	249	7	p.k	p.k	PROPN
admet-1022	249	8	.	.	PROPN
admet-1022	249	9	singh	singh	PROPN
admet-1022	249	10	.	.	PUNCT
admet-1022	250	1	analyzing	analyze	VERB
admet-1022	250	2	fda	fda	PROPN
admet-1022	250	3	-	-	PUNCT
admet-1022	250	4	approved	approve	VERB
admet-1022	250	5	drugs	drug	NOUN
admet-1022	250	6	for	for	ADP
admet-1022	250	7	compliance	compliance	NOUN
admet-1022	250	8	of	of	ADP
admet-1022	250	9	pharmacokinetic	pharmacokinetic	ADJ
admet-1022	250	10	principles	principle	NOUN
admet-1022	250	11	:	:	PUNCT
admet-1022	250	12	should	should	AUX
admet-1022	250	13	there	there	PRON
admet-1022	250	14	be	be	AUX
admet-1022	250	15	a	a	DET
admet-1022	250	16	critical	critical	ADJ
admet-1022	250	17	screening	screening	NOUN
admet-1022	250	18	parameter	parameter	NOUN
admet-1022	250	19	in	in	ADP
admet-1022	250	20	drug	drug	NOUN
admet-1022	250	21	designing	design	VERB
admet-1022	250	22	protocols	protocol	NOUN
admet-1022	250	23	?	?	PUNCT
admet-1022	250	24	,	,	PUNCT
admet-1022	250	25	expert	expert	ADJ
admet-1022	250	26	opinion	opinion	NOUN
admet-1022	250	27	on	on	ADP
admet-1022	250	28	drug	drug	NOUN
admet-1022	250	29	metabolism	metabolism	NOUN
admet-1022	250	30	&	&	CCONJ
admet-1022	250	31	toxicology	toxicology	NOUN
admet-1022	250	32	17	17	NUM
admet-1022	250	33	(	(	PUNCT
admet-1022	250	34	2021	2021	NUM
admet-1022	250	35	)	)	PUNCT
admet-1022	250	36	4	4	NUM
admet-1022	250	37	,	,	PUNCT
admet-1022	250	38	351	351	NUM
admet-1022	250	39	-	-	SYM
admet-1022	250	40	354	354	NUM
admet-1022	250	41	.	.	PUNCT
admet-1022	251	1	https://doi.org/10.1080/17425255.2021.1865309	https://doi.org/10.1080/17425255.2021.1865309	PROPN
admet-1022	251	2	.	.	PUNCT
admet-1022	252	1	[	[	X
admet-1022	252	2	13	13	NUM
admet-1022	252	3	]	]	X
admet-1022	252	4	d.a	d.a	PROPN
admet-1022	252	5	.	.	PROPN
admet-1022	252	6	degoey	degoey	PROPN
admet-1022	252	7	,	,	PUNCT
admet-1022	252	8	h	h	PROPN
admet-1022	252	9	-	-	PUNCT
admet-1022	252	10	j	j	PROPN
admet-1022	252	11	chen	chen	PROPN
admet-1022	252	12	,	,	PUNCT
admet-1022	252	13	p.	p.	PROPN
admet-1022	252	14	b.	b.	PROPN
admet-1022	252	15	cox	cox	PROPN
admet-1022	252	16	,	,	PUNCT
admet-1022	252	17	m.	m.	PROPN
admet-1022	252	18	d.	d.	PROPN
admet-1022	252	19	wendt	wendt	PROPN
admet-1022	252	20	.	.	PUNCT
admet-1022	253	1	beyond	beyond	ADP
admet-1022	253	2	the	the	DET
admet-1022	253	3	rule	rule	NOUN
admet-1022	253	4	of	of	ADP
admet-1022	253	5	5	5	NUM
admet-1022	253	6	:	:	PUNCT
admet-1022	253	7	lessons	lesson	NOUN
admet-1022	253	8	learned	learn	VERB
admet-1022	253	9	from	from	ADP
admet-1022	253	10	abbvie	abbvie	PROPN
admet-1022	253	11	’s	’s	PART
admet-1022	253	12	drugs	drug	NOUN
admet-1022	253	13	and	and	CCONJ
admet-1022	253	14	compound	compound	NOUN
admet-1022	253	15	collection	collection	NOUN
admet-1022	253	16	journal	journal	NOUN
admet-1022	253	17	of	of	ADP
admet-1022	253	18	medicinal	medicinal	ADJ
admet-1022	253	19	chemistry	chemistry	NOUN
admet-1022	253	20	61	61	NUM
admet-1022	253	21	(	(	PUNCT
admet-1022	253	22	2018	2018	NUM
admet-1022	253	23	)	)	PUNCT
admet-1022	253	24	2636−2651	2636−2651	NUM
admet-1022	253	25	.	.	PUNCT
admet-1022	254	1	https://doi.org/10.1021/acs.jmedchem.7b00717	https://doi.org/10.1021/acs.jmedchem.7b00717	ADJ
admet-1022	254	2	.	.	PUNCT
admet-1022	255	1	[	[	X
admet-1022	255	2	14	14	NUM
admet-1022	255	3	]	]	X
admet-1022	255	4	a.l	a.l	PROPN
admet-1022	255	5	.	.	PROPN
admet-1022	255	6	hopkins	hopkins	PROPN
admet-1022	255	7	,	,	PUNCT
admet-1022	255	8	c.r	c.r	PROPN
admet-1022	255	9	.	.	PROPN
admet-1022	255	10	groom	groom	PROPN
admet-1022	255	11	,	,	PUNCT
admet-1022	255	12	a.	a.	PROPN
admet-1022	255	13	alex	alex	PROPN
admet-1022	255	14	.	.	PROPN
admet-1022	255	15	ligand	ligand	PROPN
admet-1022	255	16	efficiency	efficiency	NOUN
admet-1022	255	17	:	:	PUNCT
admet-1022	255	18	a	a	DET
admet-1022	255	19	useful	useful	ADJ
admet-1022	255	20	metric	metric	NOUN
admet-1022	255	21	for	for	ADP
admet-1022	255	22	lead	lead	ADJ
admet-1022	255	23	selection	selection	NOUN
admet-1022	255	24	.	.	PUNCT
admet-1022	256	1	drug	drug	NOUN
admet-1022	256	2	discovery	discovery	PROPN
admet-1022	256	3	today	today	NOUN
admet-1022	256	4	9	9	NUM
admet-1022	256	5	(	(	PUNCT
admet-1022	256	6	2004	2004	NUM
admet-1022	256	7	)	)	PUNCT
admet-1022	256	8	430	430	NUM
admet-1022	256	9	-	-	SYM
admet-1022	256	10	431	431	NUM
admet-1022	256	11	.	.	PUNCT
admet-1022	257	1	https://doi.org/10.1016/s1359-6446(04)03069-7	https://doi.org/10.1016/s1359-6446(04)03069-7	NOUN
admet-1022	257	2	.	.	PUNCT
admet-1022	258	1	[	[	X
admet-1022	258	2	15	15	NUM
admet-1022	258	3	]	]	X
admet-1022	258	4	a.l	a.l	PROPN
admet-1022	258	5	.	.	PROPN
admet-1022	258	6	hopkins	hopkins	PROPN
admet-1022	258	7	,	,	PUNCT
admet-1022	258	8	g.m	g.m	PROPN
admet-1022	258	9	.	.	PROPN
admet-1022	258	10	keserü	keserü	PROPN
admet-1022	258	11	,	,	PUNCT
admet-1022	258	12	p.d	p.d	PROPN
admet-1022	258	13	.	.	PROPN
admet-1022	258	14	leeson	leeson	PROPN
admet-1022	258	15	,	,	PUNCT
admet-1022	258	16	d.c	d.c	PROPN
admet-1022	258	17	.	.	PROPN
admet-1022	258	18	rees	rees	PROPN
admet-1022	258	19	,	,	PUNCT
admet-1022	258	20	c.m	c.m	PROPN
admet-1022	258	21	.	.	PROPN
admet-1022	258	22	reynolds	reynolds	PROPN
admet-1022	258	23	.	.	PUNCT
admet-1022	259	1	the	the	DET
admet-1022	259	2	role	role	NOUN
admet-1022	259	3	of	of	ADP
admet-1022	259	4	ligand	ligand	ADJ
admet-1022	259	5	efficiency	efficiency	NOUN
admet-1022	259	6	metrics	metric	NOUN
admet-1022	259	7	in	in	ADP
admet-1022	259	8	drug	drug	NOUN
admet-1022	259	9	discovery	discovery	NOUN
admet-1022	259	10	.	.	PUNCT
admet-1022	260	1	nature	nature	NOUN
admet-1022	260	2	reviews	review	VERB
admet-1022	260	3	drug	drug	NOUN
admet-1022	260	4	discovery	discovery	NOUN
admet-1022	260	5	13	13	NUM
admet-1022	260	6	(	(	PUNCT
admet-1022	260	7	2014	2014	NUM
admet-1022	260	8	)	)	PUNCT
admet-1022	260	9	105	105	NUM
admet-1022	260	10	-	-	SYM
admet-1022	260	11	121	121	NUM
admet-1022	260	12	.	.	PUNCT
admet-1022	261	1	https://doi.org/10.1038/nrd4163	https://doi.org/10.1038/nrd4163	PROPN
admet-1022	261	2	.	.	PUNCT
admet-1022	262	1	[	[	X
admet-1022	262	2	16	16	NUM
admet-1022	262	3	]	]	X
admet-1022	262	4	g.m.keserű	g.m.keserű	PROPN
admet-1022	262	5	,	,	PUNCT
admet-1022	262	6	g.m	g.m	PROPN
admet-1022	262	7	.	.	PROPN
admet-1022	262	8	makara	makara	PROPN
admet-1022	262	9	.	.	PUNCT
admet-1022	263	1	the	the	DET
admet-1022	263	2	influence	influence	NOUN
admet-1022	263	3	of	of	ADP
admet-1022	263	4	lead	lead	ADJ
admet-1022	263	5	discovery	discovery	NOUN
admet-1022	263	6	strategies	strategy	NOUN
admet-1022	263	7	on	on	ADP
admet-1022	263	8	the	the	DET
admet-1022	263	9	properties	property	NOUN
admet-1022	263	10	of	of	ADP
admet-1022	263	11	drug	drug	NOUN
admet-1022	263	12	candidates	candidate	NOUN
admet-1022	263	13	.	.	PUNCT
admet-1022	264	1	nature	nature	NOUN
admet-1022	264	2	reviews	review	VERB
admet-1022	264	3	drug	drug	NOUN
admet-1022	264	4	discovery	discovery	NOUN
admet-1022	264	5	8	8	NUM
admet-1022	264	6	(	(	PUNCT
admet-1022	264	7	2009	2009	NUM
admet-1022	264	8	)	)	PUNCT
admet-1022	264	9	203	203	NUM
admet-1022	264	10	-	-	SYM
admet-1022	264	11	12	12	NUM
admet-1022	264	12	.	.	PUNCT
admet-1022	265	1	https://doi.org/10.1038/nrd2796	https://doi.org/10.1038/nrd2796	PRON
admet-1022	265	2	.	.	PUNCT
admet-1022	266	1	[	[	X
admet-1022	266	2	17	17	NUM
admet-1022	266	3	]	]	X
admet-1022	266	4	a.k	a.k	PROPN
admet-1022	266	5	.	.	PROPN
admet-1022	266	6	ghose	ghose	PROPN
admet-1022	266	7	,	,	PUNCT
admet-1022	266	8	v.n	v.n	PROPN
admet-1022	266	9	.	.	PROPN
admet-1022	266	10	viswanadhan	viswanadhan	PROPN
admet-1022	266	11	,	,	PUNCT
admet-1022	266	12	j.j	j.j	PROPN
admet-1022	266	13	.	.	PROPN
admet-1022	266	14	wendoloski	wendoloski	PROPN
admet-1022	266	15	.	.	PUNCT
admet-1022	267	1	a	a	DET
admet-1022	267	2	knowledge	knowledge	NOUN
admet-1022	267	3	-	-	PUNCT
admet-1022	267	4	based	base	VERB
admet-1022	267	5	approach	approach	NOUN
admet-1022	267	6	in	in	ADP
admet-1022	267	7	designing	design	VERB
admet-1022	267	8	combinatorial	combinatorial	ADJ
admet-1022	267	9	or	or	CCONJ
admet-1022	267	10	medicinal	medicinal	ADJ
admet-1022	267	11	chemistry	chemistry	NOUN
admet-1022	267	12	libraries	library	NOUN
admet-1022	267	13	for	for	ADP
admet-1022	267	14	drug	drug	NOUN
admet-1022	267	15	discovery	discovery	NOUN
admet-1022	267	16	.	.	PUNCT
admet-1022	268	1	1	1	X
admet-1022	268	2	.	.	X
admet-1022	268	3	a	a	DET
admet-1022	268	4	qualitative	qualitative	ADJ
admet-1022	268	5	and	and	CCONJ
admet-1022	268	6	quantitative	quantitative	ADJ
admet-1022	268	7	characterization	characterization	NOUN
admet-1022	268	8	of	of	ADP
admet-1022	268	9	known	know	VERB
admet-1022	268	10	drug	drug	NOUN
admet-1022	268	11	databases	database	NOUN
admet-1022	268	12	.	.	PUNCT
admet-1022	269	1	journal	journal	NOUN
admet-1022	269	2	of	of	ADP
admet-1022	269	3	combinatorial	combinatorial	ADJ
admet-1022	269	4	chemistry	chemistry	NOUN
admet-1022	269	5	1	1	NUM
admet-1022	269	6	(	(	PUNCT
admet-1022	269	7	1999	1999	NUM
admet-1022	269	8	)	)	PUNCT
admet-1022	269	9	55	55	NUM
admet-1022	269	10	-	-	SYM
admet-1022	269	11	68	68	NUM
admet-1022	269	12	.	.	PUNCT
admet-1022	270	1	https://doi.org/10.1021/cc9800071	https://doi.org/10.1021/cc9800071	ADJ
admet-1022	270	2	.	.	PUNCT
admet-1022	271	1	[	[	X
admet-1022	271	2	18	18	NUM
admet-1022	271	3	]	]	PUNCT
admet-1022	271	4	f.yoshida	f.yoshida	NUM
admet-1022	271	5	,	,	PUNCT
admet-1022	271	6	j.g	j.g	PROPN
admet-1022	271	7	.	.	PROPN
admet-1022	271	8	topliss	topliss	PROPN
admet-1022	271	9	.	.	PUNCT
admet-1022	271	10	qsar	qsar	NOUN
admet-1022	271	11	model	model	NOUN
admet-1022	271	12	for	for	ADP
admet-1022	271	13	drug	drug	NOUN
admet-1022	271	14	human	human	ADJ
admet-1022	271	15	oral	oral	ADJ
admet-1022	271	16	bioavailability	bioavailability	NOUN
admet-1022	271	17	.	.	PUNCT
admet-1022	272	1	journal	journal	PROPN
admet-1022	272	2	of	of	ADP
admet-1022	272	3	medicinal	medicinal	ADJ
admet-1022	272	4	chemistry	chemistry	NOUN
admet-1022	272	5	43	43	NUM
admet-1022	272	6	(	(	PUNCT
admet-1022	272	7	2000	2000	NUM
admet-1022	272	8	)	)	PUNCT
admet-1022	272	9	2575	2575	NUM
admet-1022	272	10	-	-	SYM
admet-1022	272	11	85	85	NUM
admet-1022	272	12	.	.	PUNCT
admet-1022	273	1	https://doi.org/10.1021/jm0000564	https://doi.org/10.1021/jm0000564	ADP
admet-1022	273	2	.	.	PUNCT
admet-1022	274	1	[	[	X
admet-1022	274	2	19	19	NUM
admet-1022	274	3	]	]	X
admet-1022	274	4	j.e.a	j.e.a	ADJ
admet-1022	274	5	,	,	PUNCT
admet-1022	274	6	comer	comer	NOUN
admet-1022	274	7	.	.	PUNCT
admet-1022	274	8	drug	drug	NOUN
admet-1022	274	9	bioavailability	bioavailability	NOUN
admet-1022	274	10	:	:	PUNCT
admet-1022	274	11	estimation	estimation	NOUN
admet-1022	274	12	of	of	ADP
admet-1022	274	13	solubility	solubility	NOUN
admet-1022	274	14	,	,	PUNCT
admet-1022	274	15	permeability	permeability	NOUN
admet-1022	274	16	,	,	PUNCT
admet-1022	274	17	absorption	absorption	NOUN
admet-1022	274	18	and	and	CCONJ
admet-1022	274	19	bioavailability	bioavailability	NOUN
admet-1022	274	20	methods	method	NOUN
admet-1022	274	21	and	and	CCONJ
admet-1022	274	22	principles	principle	NOUN
admet-1022	274	23	in	in	ADP
admet-1022	274	24	medicinal	medicinal	ADJ
admet-1022	274	25	chemistry	chemistry	NOUN
admet-1022	274	26	,	,	PUNCT
admet-1022	274	27	h.van	h.van	PROPN
admet-1022	274	28	de	de	X
admet-1022	274	29	waterbeemd	waterbeemd	PROPN
admet-1022	274	30	,	,	PUNCT
admet-1022	274	31	h.	h.	PROPN
admet-1022	274	32	lennernäs	lennernäs	PROPN
admet-1022	274	33	,	,	PUNCT
admet-1022	274	34	p.	p.	PROPN
admet-1022	274	35	artursson	artursson	PROPN
admet-1022	274	36	eds	eds	PROPN
admet-1022	274	37	,	,	PUNCT
admet-1022	274	38	wiley	wiley	PROPN
admet-1022	274	39	vch	vch	PROPN
admet-1022	274	40	,	,	PUNCT
admet-1022	274	41	weinheim	weinheim	PROPN
admet-1022	274	42	,	,	PUNCT
admet-1022	274	43	2003	2003	NUM
admet-1022	274	44	.	.	PUNCT
admet-1022	275	1	p.	p.	NOUN
admet-1022	275	2	21	21	NUM
admet-1022	275	3	-	-	SYM
admet-1022	275	4	45	45	NUM
admet-1022	275	5	.	.	PUNCT
admet-1022	276	1	https://doi.org/10.1002/3527601473.ch2	https://doi.org/10.1002/3527601473.ch2	NOUN
admet-1022	276	2	.	.	PUNCT
admet-1022	277	1	[	[	X
admet-1022	277	2	20	20	NUM
admet-1022	277	3	]	]	X
admet-1022	277	4	m.j	m.j	PROPN
admet-1022	277	5	.	.	PROPN
admet-1022	277	6	waring	waring	NOUN
admet-1022	277	7	.	.	PUNCT
admet-1022	278	1	defining	define	VERB
admet-1022	278	2	optimum	optimum	ADJ
admet-1022	278	3	lipophilicity	lipophilicity	NOUN
admet-1022	278	4	and	and	CCONJ
admet-1022	278	5	molecular	molecular	ADJ
admet-1022	278	6	weight	weight	NOUN
admet-1022	278	7	ranges	range	VERB
admet-1022	278	8	for	for	ADP
admet-1022	278	9	drug	drug	NOUN
admet-1022	278	10	candidatesmolecular	candidatesmolecular	VERB
admet-1022	278	11	weight	weight	NOUN
admet-1022	278	12	dependent	dependent	ADJ
admet-1022	278	13	lower	low	ADJ
admet-1022	278	14	logd	logd	NOUN
admet-1022	278	15	limits	limit	NOUN
admet-1022	278	16	based	base	VERB
admet-1022	278	17	on	on	ADP
admet-1022	278	18	permeability	permeability	NOUN
admet-1022	278	19	.	.	PUNCT
admet-1022	279	1	biorganic	biorganic	ADJ
admet-1022	279	2	medicinal	medicinal	ADJ
admet-1022	279	3	chemistry	chemistry	NOUN
admet-1022	279	4	letters	letter	NOUN
admet-1022	279	5	19	19	NUM
admet-1022	279	6	(	(	PUNCT
admet-1022	279	7	2009	2009	NUM
admet-1022	279	8	)	)	PUNCT
admet-1022	279	9	2844	2844	NUM
admet-1022	279	10	-	-	SYM
admet-1022	279	11	2851	2851	NUM
admet-1022	279	12	.	.	PUNCT
admet-1022	280	1	https://doi.org/10.1016/j.bmcl.2009.03.109	https://doi.org/10.1016/j.bmcl.2009.03.109	VERB
admet-1022	280	2	.	.	PUNCT
admet-1022	281	1	[	[	X
admet-1022	281	2	21	21	NUM
admet-1022	281	3	]	]	X
admet-1022	281	4	g.	g.	PROPN
admet-1022	281	5	camenisch	camenisch	PROPN
admet-1022	281	6	,	,	PUNCT
admet-1022	281	7	j.	j.	PROPN
admet-1022	281	8	alsenz	alsenz	PROPN
admet-1022	281	9	,	,	PUNCT
admet-1022	281	10	h.	h.	PROPN
admet-1022	281	11	van	van	PROPN
admet-1022	281	12	de	de	PROPN
admet-1022	281	13	waterbeemd	waterbeemd	PROPN
admet-1022	281	14	,	,	PUNCT
admet-1022	281	15	g.	g.	PROPN
admet-1022	281	16	folkers	folker	NOUN
admet-1022	281	17	.	.	PUNCT
admet-1022	282	1	estimation	estimation	NOUN
admet-1022	282	2	of	of	ADP
admet-1022	282	3	permeability	permeability	NOUN
admet-1022	282	4	by	by	ADP
admet-1022	282	5	passive	passive	ADJ
admet-1022	282	6	diffusion	diffusion	NOUN
admet-1022	282	7	through	through	ADP
admet-1022	282	8	caco-2	caco-2	NUM
admet-1022	282	9	cell	cell	NOUN
admet-1022	282	10	monolayers	monolayer	NOUN
admet-1022	282	11	using	use	VERB
admet-1022	282	12	the	the	DET
admet-1022	282	13	drugs	drug	NOUN
admet-1022	282	14	’	'	PUNCT
admet-1022	282	15	lipophilicity	lipophilicity	NOUN
admet-1022	282	16	and	and	CCONJ
admet-1022	282	17	molecular	molecular	ADJ
admet-1022	282	18	weight	weight	NOUN
admet-1022	282	19	.	.	PUNCT
admet-1022	283	1	european	european	ADJ
admet-1022	283	2	journal	journal	PROPN
admet-1022	283	3	of	of	ADP
admet-1022	283	4	pharmaceutical	pharmaceutical	PROPN
admet-1022	283	5	sciences	science	NOUN
admet-1022	283	6	6	6	NUM
admet-1022	283	7	(	(	PUNCT
admet-1022	283	8	1998	1998	NUM
admet-1022	283	9	)	)	PUNCT
admet-1022	284	1	313–319	313–319	NUM
admet-1022	284	2	.	.	PUNCT
admet-1022	285	1	https://doi.org/10.1016/s09280987(97)10019-7	https://doi.org/10.1016/s09280987(97)10019-7	NOUN
admet-1022	285	2	.	.	PUNCT
admet-1022	286	1	[	[	X
admet-1022	286	2	22	22	NUM
admet-1022	286	3	]	]	SYM
admet-1022	286	4	b.testa	b.testa	ADJ
admet-1022	286	5	,	,	PUNCT
admet-1022	286	6	p.-a	p.-a	NOUN
admet-1022	286	7	.	.	PUNCT
admet-1022	287	1	carrupt	carrupt	PROPN
admet-1022	287	2	,	,	PUNCT
admet-1022	287	3	p.	p.	PROPN
admet-1022	287	4	gaillard	gaillard	PROPN
admet-1022	287	5	,	,	PUNCT
admet-1022	287	6	and	and	CCONJ
admet-1022	287	7	r.-s	r.-	NOUN
admet-1022	287	8	.	.	PUNCT
admet-1022	288	1	tsai	tsai	PROPN
admet-1022	288	2	,	,	PUNCT
admet-1022	288	3	r.-s	r.-	NOUN
admet-1022	288	4	.	.	PUNCT
admet-1022	289	1	intramolecular	intramolecular	ADJ
admet-1022	289	2	interactions	interaction	NOUN
admet-1022	289	3	encoded	encode	VERB
admet-1022	289	4	in	in	ADP
admet-1022	289	5	lipophilicity	lipophilicity	NOUN
admet-1022	289	6	:	:	PUNCT
admet-1022	289	7	their	their	PRON
admet-1022	289	8	nature	nature	NOUN
admet-1022	289	9	and	and	CCONJ
admet-1022	289	10	significance	significance	NOUN
admet-1022	289	11	.	.	PUNCT
admet-1022	290	1	v.	v.	ADP
admet-1022	290	2	pliska	pliska	PROPN
admet-1022	290	3	,	,	PUNCT
admet-1022	290	4	b.testa	b.testa	ADJ
admet-1022	290	5	,	,	PUNCT
admet-1022	290	6	and	and	CCONJ
admet-1022	290	7	h.	h.	PROPN
admet-1022	290	8	van	van	PROPN
admet-1022	290	9	de	de	PROPN
admet-1022	290	10	waterbeemd	waterbeemd	PROPN
admet-1022	290	11	,	,	PUNCT
admet-1022	290	12	h.	h.	PROPN
admet-1022	290	13	eds	eds	PROPN
admet-1022	290	14	.	.	PUNCT
admet-1022	291	1	lipophilicity	lipophilicity	NOUN
admet-1022	291	2	in	in	ADP
admet-1022	291	3	drug	drug	NOUN
admet-1022	291	4	action	action	NOUN
admet-1022	291	5	and	and	CCONJ
admet-1022	291	6	toxicology	toxicology	NOUN
admet-1022	291	7	.	.	PUNCT
admet-1022	292	1	weinheim	weinheim	PROPN
admet-1022	292	2	:	:	PUNCT
admet-1022	292	3	vch	vch	PROPN
admet-1022	292	4	,	,	PUNCT
admet-1022	292	5	1995	1995	NUM
admet-1022	292	6	pp	pp	NOUN
admet-1022	292	7	.	.	PUNCT
admet-1022	293	1	49	49	NUM
admet-1022	293	2	-	-	SYM
admet-1022	293	3	71	71	NUM
admet-1022	293	4	.	.	PUNCT
admet-1022	294	1	[	[	X
admet-1022	294	2	23	23	NUM
admet-1022	294	3	]	]	PUNCT
admet-1022	294	4	a.	a.	NOUN
admet-1022	294	5	tsantili	tsantili	NOUN
admet-1022	294	6	-	-	PUNCT
admet-1022	294	7	kakoulidou	kakoulidou	NOUN
admet-1022	294	8	,	,	PUNCT
admet-1022	294	9	m.	m.	NOUN
admet-1022	294	10	chatzopoulou	chatzopoulou	PROPN
admet-1022	294	11	,	,	PUNCT
admet-1022	294	12	and	and	CCONJ
admet-1022	294	13	v.	v.	PROPN
admet-1022	294	14	j.	j.	PROPN
admet-1022	294	15	demopoulos	demopoulos	PROPN
admet-1022	294	16	.	.	PUNCT
admet-1022	295	1	fraction	fraction	NOUN
admet-1022	295	2	lipophilicity	lipophilicity	PROPN
admet-1022	295	3	index	index	NOUN
admet-1022	295	4	(	(	PUNCT
admet-1022	295	5	fli	fli	NOUN
admet-1022	295	6	):	):	PUNCT
admet-1022	295	7	a	a	DET
admet-1022	295	8	metric	metric	NOUN
admet-1022	295	9	for	for	ADP
admet-1022	295	10	assessing	assess	VERB
admet-1022	295	11	oral	oral	ADJ
admet-1022	295	12	drug	drug	NOUN
admet-1022	295	13	-	-	PUNCT
admet-1022	295	14	likeness	likeness	NOUN
admet-1022	295	15	of	of	ADP
admet-1022	295	16	ionizable	ionizable	ADJ
admet-1022	295	17	chemical	chemical	ADJ
admet-1022	295	18	entities	entity	NOUN
admet-1022	295	19	.	.	PUNCT
admet-1022	296	1	international	international	ADJ
admet-1022	296	2	journal	journal	NOUN
admet-1022	296	3	of	of	ADP
admet-1022	296	4	quantitative	quantitative	ADJ
admet-1022	296	5	structure	structure	NOUN
admet-1022	296	6	-	-	PUNCT
admet-1022	296	7	property	property	NOUN
admet-1022	296	8	relationships	relationship	NOUN
admet-1022	296	9	.	.	PUNCT
admet-1022	297	1	4	4	NUM
admet-1022	297	2	(	(	PUNCT
admet-1022	297	3	2019	2019	NUM
admet-1022	297	4	)	)	PUNCT
admet-1022	297	5	41	41	NUM
admet-1022	297	6	-	-	SYM
admet-1022	297	7	66	66	NUM
admet-1022	297	8	.	.	PUNCT
admet-1022	298	1	https://doi.org/10.4018/ijqspr.2019010104	https://doi.org/10.4018/ijqspr.2019010104	PROPN
admet-1022	298	2	.	.	PUNCT
admet-1022	299	1	https://doi.org/10.5599/admet.1022	https://doi.org/10.5599/admet.1022	X
admet-1022	300	1	https://doi.org/10.1002/jps.2600760902	https://doi.org/10.1002/jps.2600760902	PROPN
admet-1022	300	2	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
admet-1022	300	3	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	PROPN
admet-1022	300	4	https://www.ncbi.nlm.nih.gov/pubmed/12489682	https://www.ncbi.nlm.nih.gov/pubmed/12489682	NOUN
admet-1022	300	5	https://link.springer.com/journal/10822	https://link.springer.com/journal/10822	NOUN
admet-1022	300	6	https://link.springer.com/journal/10822	https://link.springer.com/journal/10822	NOUN
admet-1022	300	7	https://doi.org/10.1023/a:1020877402759	https://doi.org/10.1023/a:1020877402759	PROPN
admet-1022	300	8	https://doi.org/10.1016/j.drudis.2014.01.007	https://doi.org/10.1016/j.drudis.2014.01.007	VERB
admet-1022	300	9	https://doi.org/10.1016/j.drudis.2014.01.007	https://doi.org/10.1016/j.drudis.2014.01.007	NOUN
admet-1022	300	10	https://doi.org/10.1080/17425255.2021.1865309	https://doi.org/10.1080/17425255.2021.1865309	PROPN
admet-1022	301	1	https://doi.org/10.1021/acs.jmedchem.7b00717	https://doi.org/10.1021/acs.jmedchem.7b00717	PRON
admet-1022	301	2	https://doi.org/10.1016/s1359-6446(04)03069-7	https://doi.org/10.1016/s1359-6446(04)03069-7	NOUN
admet-1022	301	3	https://doi.org/10.1038/nrd4163	https://doi.org/10.1038/nrd4163	PROPN
admet-1022	301	4	https://doi.org/10.1038/nrd4163	https://doi.org/10.1038/nrd4163	PROPN
admet-1022	301	5	https://doi.org/10.1038/nrd2796	https://doi.org/10.1038/nrd2796	ADV
admet-1022	301	6	https://doi.org/10.1021/cc9800071	https://doi.org/10.1021/cc9800071	X
admet-1022	301	7	https://doi.org/10.1021/jm0000564	https://doi.org/10.1021/jm0000564	NUM
admet-1022	301	8	https://onlinelibrary.wiley.com/action/dosearch?contribauthorstored=lennern%c3%a4s%2c+hans	https://onlinelibrary.wiley.com/action/dosearch?contribauthorstored=lennern%c3%a4s%2c+han	NOUN
admet-1022	301	9	https://onlinelibrary.wiley.com/action/dosearch?contribauthorstored=artursson%2c+per	https://onlinelibrary.wiley.com/action/dosearch?contribauthorstored=artursson%2c+per	ADP
admet-1022	301	10	https://doi.org/10.1002/3527601473.ch2	https://doi.org/10.1002/3527601473.ch2	PROPN
admet-1022	301	11	https://doi.org/10.1016/j.bmcl.2009.03.109	https://doi.org/10.1016/j.bmcl.2009.03.109	VERB
admet-1022	301	12	https://doi.org/10.1016/s0928-0987(97)10019-7	https://doi.org/10.1016/s0928-0987(97)10019-7	PROPN
admet-1022	301	13	https://doi.org/10.1016/s0928-0987(97)10019-7	https://doi.org/10.1016/s0928-0987(97)10019-7	PROPN
admet-1022	301	14	https://doi.org/10.4018/ijqspr.2019010104	https://doi.org/10.4018/ijqspr.2019010104	PROPN
admet-1022	301	15	https://doi.org/10.4018/ijqspr.2019010104	https://doi.org/10.4018/ijqspr.2019010104	NOUN
admet-1022	301	16	tsantili	tsantili	NOUN
admet-1022	301	17	-	-	PUNCT
admet-1022	301	18	kakoulidou	kakoulidou	NOUN
admet-1022	301	19	and	and	CCONJ
admet-1022	301	20	demopoulos	demopoulos	PROPN
admet-1022	301	21	admet	admet	PROPN
admet-1022	301	22	&	&	CCONJ
admet-1022	301	23	dmpk	dmpk	PROPN
admet-1022	301	24	9(3	9(3	NUM
admet-1022	301	25	)	)	PUNCT
admet-1022	301	26	(	(	PUNCT
admet-1022	301	27	2021	2021	NUM
admet-1022	301	28	)	)	PUNCT
admet-1022	301	29	177	177	NUM
admet-1022	301	30	-	-	SYM
admet-1022	301	31	190	190	NUM
admet-1022	301	32	190	190	NUM
admet-1022	301	33	[	[	X
admet-1022	301	34	24	24	NUM
admet-1022	301	35	]	]	PUNCT
admet-1022	301	36	a.	a.	NOUN
admet-1022	301	37	tsantili	tsantili	NOUN
admet-1022	301	38	-	-	PUNCT
admet-1022	301	39	kakoulidou	kakoulidou	NOUN
admet-1022	301	40	,	,	PUNCT
admet-1022	301	41	v.j	v.j	PROPN
admet-1022	301	42	.	.	PROPN
admet-1022	301	43	demopoulos	demopoulos	PROPN
admet-1022	301	44	.	.	PUNCT
admet-1022	302	1	fraction	fraction	NOUN
admet-1022	302	2	lipophilicity	lipophilicity	PROPN
admet-1022	302	3	index	index	NOUN
admet-1022	302	4	(	(	PUNCT
admet-1022	302	5	fli	fli	NOUN
admet-1022	302	6	)	)	PUNCT
admet-1022	302	7	.	.	PUNCT
admet-1022	303	1	a	a	DET
admet-1022	303	2	drug	drug	NOUN
admet-1022	303	3	-	-	PUNCT
admet-1022	303	4	like	like	ADJ
admet-1022	303	5	metric	metric	NOUN
admet-1022	303	6	for	for	ADP
admet-1022	303	7	orally	orally	ADV
admet-1022	303	8	administered	administer	VERB
admet-1022	303	9	ionizable	ionizable	ADJ
admet-1022	303	10	drugs	drug	NOUN
admet-1022	303	11	.	.	PUNCT
admet-1022	304	1	sar	sar	PROPN
admet-1022	304	2	and	and	CCONJ
admet-1022	304	3	qsar	qsar	VERB
admet-1022	304	4	in	in	ADP
admet-1022	304	5	environmental	environmental	ADJ
admet-1022	304	6	research	research	NOUN
admet-1022	304	7	.	.	PUNCT
admet-1022	305	1	30	30	NUM
admet-1022	305	2	(	(	PUNCT
admet-1022	305	3	2019	2019	NUM
admet-1022	305	4	)	)	PUNCT
admet-1022	305	5	643	643	NUM
admet-1022	305	6	-	-	SYM
admet-1022	305	7	653	653	NUM
admet-1022	305	8	.	.	PUNCT
admet-1022	306	1	https://doi.org/10.1080/1062936x.2019.1653363	https://doi.org/10.1080/1062936x.2019.1653363	PROPN
admet-1022	306	2	.	.	PUNCT
admet-1022	307	1	[	[	X
admet-1022	307	2	25	25	NUM
admet-1022	307	3	]	]	PUNCT
admet-1022	307	4	d.	d.	PROPN
admet-1022	307	5	newby	newby	PROPN
admet-1022	307	6	,	,	PUNCT
admet-1022	307	7	a.a	a.a	PROPN
admet-1022	307	8	.	.	PROPN
admet-1022	307	9	freitas	freitas	PROPN
admet-1022	307	10	,	,	PUNCT
admet-1022	307	11	t.	t.	NOUN
admet-1022	307	12	ghafourian	ghafourian	NOUN
admet-1022	307	13	.	.	PUNCT
admet-1022	308	1	decision	decision	NOUN
admet-1022	308	2	trees	tree	NOUN
admet-1022	308	3	to	to	PART
admet-1022	308	4	characterise	characterise	VERB
admet-1022	308	5	the	the	DET
admet-1022	308	6	roles	role	NOUN
admet-1022	308	7	of	of	ADP
admet-1022	308	8	permeability	permeability	NOUN
admet-1022	308	9	and	and	CCONJ
admet-1022	308	10	solubility	solubility	NOUN
admet-1022	308	11	on	on	ADP
admet-1022	308	12	the	the	DET
admet-1022	308	13	prediction	prediction	NOUN
admet-1022	308	14	of	of	ADP
admet-1022	308	15	oral	oral	ADJ
admet-1022	308	16	absorption	absorption	NOUN
admet-1022	308	17	european	european	PROPN
admet-1022	308	18	journal	journal	PROPN
admet-1022	308	19	of	of	ADP
admet-1022	308	20	medicinal	medicinal	ADJ
admet-1022	308	21	chemistry	chemistry	NOUN
admet-1022	308	22	.	.	PUNCT
admet-1022	309	1	90	90	NUM
admet-1022	309	2	(	(	PUNCT
admet-1022	309	3	2015	2015	NUM
admet-1022	309	4	)	)	PUNCT
admet-1022	309	5	751	751	NUM
admet-1022	309	6	-	-	SYM
admet-1022	309	7	65	65	NUM
admet-1022	309	8	.	.	PUNCT
admet-1022	310	1	https://doi.org/10.1016/j.ejmech.2014.12.006	https://doi.org/10.1016/j.ejmech.2014.12.006	NOUN
admet-1022	310	2	.	.	PUNCT
admet-1022	311	1	[	[	X
admet-1022	311	2	26	26	NUM
admet-1022	311	3	]	]	PUNCT
admet-1022	311	4	i.	i.	NOUN
admet-1022	311	5	moriguchi	moriguchi	PROPN
admet-1022	311	6	,	,	PUNCT
admet-1022	311	7	s.hirono	s.hirono	PROPN
admet-1022	311	8	,	,	PUNCT
admet-1022	311	9	q.	q.	PROPN
admet-1022	311	10	liu	liu	PROPN
admet-1022	311	11	,	,	PUNCT
admet-1022	311	12	i.	i.	PROPN
admet-1022	311	13	nakagome	nakagome	PROPN
admet-1022	311	14	,	,	PUNCT
admet-1022	311	15	y.matsushita	y.matsushita	PROPN
admet-1022	311	16	.	.	PUNCT
admet-1022	312	1	simple	simple	ADJ
admet-1022	312	2	method	method	NOUN
admet-1022	312	3	of	of	ADP
admet-1022	312	4	calculating	calculate	VERB
admet-1022	312	5	octanol	octanol	NOUN
admet-1022	312	6	/	/	SYM
admet-1022	312	7	water	water	NOUN
admet-1022	312	8	partition	partition	NOUN
admet-1022	312	9	coefficient	coefficient	NOUN
admet-1022	312	10	.	.	PUNCT
admet-1022	313	1	chemical	chemical	PROPN
admet-1022	313	2	&	&	CCONJ
admet-1022	313	3	pharmaceutical	pharmaceutical	PROPN
admet-1022	313	4	bulletin	bulletin	NOUN
admet-1022	313	5	40	40	NUM
admet-1022	313	6	(	(	PUNCT
admet-1022	313	7	1992	1992	NUM
admet-1022	313	8	)	)	PUNCT
admet-1022	313	9	127	127	NUM
admet-1022	313	10	-	-	SYM
admet-1022	313	11	130	130	NUM
admet-1022	313	12	.	.	PUNCT
admet-1022	314	1	https://doi.org/10.1248/cpb.40.127	https://doi.org/10.1248/cpb.40.127	NOUN
admet-1022	314	2	.	.	PUNCT
admet-1022	315	1	[	[	X
admet-1022	315	2	27	27	NUM
admet-1022	315	3	]	]	X
admet-1022	315	4	m.p.gleeson	m.p.gleeson	NOUN
admet-1022	315	5	p	p	PROPN
admet-1022	315	6	,	,	PUNCT
admet-1022	315	7	a.	a.	PROPN
admet-1022	315	8	hersey	hersey	PROPN
admet-1022	315	9	,	,	PUNCT
admet-1022	315	10	d.	d.	PROPN
admet-1022	315	11	montanari	montanari	PROPN
admet-1022	315	12	,	,	PUNCT
admet-1022	315	13	j.	j.	PROPN
admet-1022	315	14	overington	overington	PROPN
admet-1022	315	15	.	.	PUNCT
admet-1022	316	1	probing	probe	VERB
admet-1022	316	2	the	the	DET
admet-1022	316	3	links	link	NOUN
admet-1022	316	4	between	between	ADP
admet-1022	316	5	in	in	ADP
admet-1022	316	6	vitro	vitro	X
admet-1022	316	7	potency	potency	NOUN
admet-1022	316	8	,	,	PUNCT
admet-1022	316	9	admet	admet	PROPN
admet-1022	316	10	and	and	CCONJ
admet-1022	316	11	physicochemical	physicochemical	ADJ
admet-1022	316	12	parameters	parameter	NOUN
admet-1022	316	13	.	.	PUNCT
admet-1022	317	1	nature	nature	NOUN
admet-1022	317	2	reviews	review	VERB
admet-1022	317	3	drug	drug	NOUN
admet-1022	317	4	discovery	discovery	NOUN
admet-1022	317	5	.	.	PUNCT
admet-1022	318	1	3	3	NUM
admet-1022	318	2	(	(	PUNCT
admet-1022	318	3	2011	2011	NUM
admet-1022	318	4	)	)	PUNCT
admet-1022	318	5	197	197	NUM
admet-1022	318	6	-	-	SYM
admet-1022	318	7	208	208	NUM
admet-1022	318	8	.	.	PUNCT
admet-1022	319	1	https://doi.org/10.1038/nrd3367	https://doi.org/10.1038/nrd3367	X
admet-1022	319	2	.	.	PUNCT
admet-1022	320	1	[	[	X
admet-1022	320	2	28	28	NUM
admet-1022	320	3	]	]	X
admet-1022	320	4	h.a	h.a	PROPN
admet-1022	320	5	.	.	PROPN
admet-1022	320	6	zhong	zhong	PROPN
admet-1022	320	7	,	,	PUNCT
admet-1022	320	8	v.	v.	ADP
admet-1022	320	9	mashinson	mashinson	PROPN
admet-1022	320	10	,	,	PUNCT
admet-1022	320	11	t.a	t.a	PROPN
admet-1022	320	12	.	.	PROPN
admet-1022	320	13	woolman	woolman	PROPN
admet-1022	320	14	,	,	PUNCT
admet-1022	320	15	m.	m.	NOUN
admet-1022	320	16	zha	zha	PROPN
admet-1022	320	17	.	.	PUNCT
admet-1022	321	1	understanding	understand	VERB
admet-1022	321	2	the	the	DET
admet-1022	321	3	molecular	molecular	ADJ
admet-1022	321	4	properties	property	NOUN
admet-1022	321	5	and	and	CCONJ
admet-1022	321	6	metabolism	metabolism	NOUN
admet-1022	321	7	of	of	ADP
admet-1022	321	8	top	top	ADJ
admet-1022	321	9	prescribed	prescribed	ADJ
admet-1022	321	10	drugs	drug	NOUN
admet-1022	321	11	.	.	PUNCT
admet-1022	322	1	current	current	ADJ
admet-1022	322	2	topics	topic	NOUN
admet-1022	322	3	in	in	ADP
admet-1022	322	4	medicinal	medicinal	ADJ
admet-1022	322	5	chemistry	chemistry	NOUN
admet-1022	322	6	.	.	PUNCT
admet-1022	323	1	13	13	NUM
admet-1022	323	2	(	(	PUNCT
admet-1022	323	3	2013	2013	NUM
admet-1022	323	4	)	)	PUNCT
admet-1022	323	5	1290	1290	NUM
admet-1022	323	6	-	-	SYM
admet-1022	323	7	1307	1307	NUM
admet-1022	323	8	.	.	PUNCT
admet-1022	324	1	https://doi.org/10.2174/15680266113139990034	https://doi.org/10.2174/15680266113139990034	NOUN
admet-1022	324	2	.	.	PUNCT
admet-1022	325	1	[	[	X
admet-1022	325	2	29	29	NUM
admet-1022	325	3	]	]	PUNCT
admet-1022	325	4	m.	m.	NOUN
admet-1022	325	5	hann	hann	PROPN
admet-1022	325	6	,	,	PUNCT
admet-1022	325	7	g.	g.	PROPN
admet-1022	325	8	keserü	keserü	PROPN
admet-1022	325	9	.	.	PUNCT
admet-1022	326	1	finding	find	VERB
admet-1022	326	2	the	the	DET
admet-1022	326	3	sweet	sweet	ADJ
admet-1022	326	4	spot	spot	NOUN
admet-1022	326	5	:	:	PUNCT
admet-1022	326	6	the	the	DET
admet-1022	326	7	role	role	NOUN
admet-1022	326	8	of	of	ADP
admet-1022	326	9	nature	nature	NOUN
admet-1022	326	10	and	and	CCONJ
admet-1022	326	11	nurture	nurture	VERB
admet-1022	326	12	in	in	ADP
admet-1022	326	13	medicinal	medicinal	ADJ
admet-1022	326	14	chemistry	chemistry	NOUN
admet-1022	326	15	.	.	PUNCT
admet-1022	327	1	nature	nature	NOUN
admet-1022	327	2	reviews	review	VERB
admet-1022	327	3	drug	drug	NOUN
admet-1022	327	4	discovery	discovery	NOUN
admet-1022	327	5	11	11	NUM
admet-1022	327	6	(	(	PUNCT
admet-1022	327	7	2012	2012	NUM
admet-1022	327	8	)	)	PUNCT
admet-1022	327	9	355–365	355–365	NUM
admet-1022	327	10	.	.	PUNCT
admet-1022	328	1	https://doi.org/10.1038/nrd3701	https://doi.org/10.1038/nrd3701	X
admet-1022	328	2	.	.	PUNCT
admet-1022	329	1	[	[	X
admet-1022	329	2	30	30	NUM
admet-1022	329	3	]	]	PUNCT
admet-1022	329	4	m.	m.	NOUN
admet-1022	329	5	shulz	shulz	PROPN
admet-1022	329	6	.	.	PUNCT
admet-1022	330	1	two	two	NUM
admet-1022	330	2	decades	decade	NOUN
admet-1022	330	3	under	under	ADP
admet-1022	330	4	the	the	DET
admet-1022	330	5	influence	influence	NOUN
admet-1022	330	6	of	of	ADP
admet-1022	330	7	the	the	DET
admet-1022	330	8	rule	rule	NOUN
admet-1022	330	9	of	of	ADP
admet-1022	330	10	five	five	NUM
admet-1022	330	11	and	and	CCONJ
admet-1022	330	12	the	the	DET
admet-1022	330	13	changing	change	VERB
admet-1022	330	14	properties	property	NOUN
admet-1022	330	15	of	of	ADP
admet-1022	330	16	approved	approve	VERB
admet-1022	330	17	oral	oral	ADJ
admet-1022	330	18	drugs	drug	NOUN
admet-1022	330	19	.	.	PUNCT
admet-1022	331	1	journal	journal	NOUN
admet-1022	331	2	of	of	ADP
admet-1022	331	3	medicinal	medicinal	ADJ
admet-1022	331	4	chemistry	chemistry	NOUN
admet-1022	331	5	62	62	NUM
admet-1022	331	6	(	(	PUNCT
admet-1022	331	7	2019	2019	NUM
admet-1022	331	8	)	)	PUNCT
admet-1022	331	9	1701–1714	1701–1714	NUM
admet-1022	331	10	.	.	PUNCT
admet-1022	332	1	https://doi.org/10.1021/acs.jmedchem.8b00686	https://doi.org/10.1021/acs.jmedchem.8b00686	X
admet-1022	332	2	.	.	PUNCT
admet-1022	333	1	[	[	X
admet-1022	333	2	31	31	NUM
admet-1022	333	3	]	]	PUNCT
admet-1022	333	4	t.	t.	NOUN
admet-1022	333	5	vallianatou	vallianatou	PROPN
admet-1022	333	6	,	,	PUNCT
admet-1022	333	7	c.	c.	PROPN
admet-1022	333	8	giaginis	giaginis	PROPN
admet-1022	333	9	,	,	PUNCT
admet-1022	333	10	a.	a.	NOUN
admet-1022	333	11	tsantili	tsantili	NOUN
admet-1022	333	12	-	-	PUNCT
admet-1022	333	13	kakoulidou	kakoulidou	NOUN
admet-1022	333	14	.	.	PUNCT
admet-1022	334	1	the	the	DET
admet-1022	334	2	impact	impact	NOUN
admet-1022	334	3	of	of	ADP
admet-1022	334	4	physicochemical	physicochemical	ADJ
admet-1022	334	5	and	and	CCONJ
admet-1022	334	6	molecular	molecular	ADJ
admet-1022	334	7	properties	property	NOUN
admet-1022	334	8	in	in	ADP
admet-1022	334	9	drug	drug	NOUN
admet-1022	334	10	design	design	NOUN
admet-1022	334	11	:	:	PUNCT
admet-1022	334	12	navigation	navigation	NOUN
admet-1022	334	13	in	in	ADP
admet-1022	334	14	the	the	DET
admet-1022	334	15	"	"	PUNCT
admet-1022	334	16	drug	drug	NOUN
admet-1022	334	17	-	-	PUNCT
admet-1022	334	18	like	like	ADJ
admet-1022	334	19	"	"	PUNCT
admet-1022	334	20	chemical	chemical	ADJ
admet-1022	334	21	space	space	NOUN
admet-1022	334	22	.	.	PUNCT
admet-1022	335	1	advances	advance	NOUN
admet-1022	335	2	in	in	ADP
admet-1022	335	3	experimental	experimental	ADJ
admet-1022	335	4	medicine	medicine	NOUN
admet-1022	335	5	and	and	CCONJ
admet-1022	335	6	biology	biology	NOUN
admet-1022	335	7	822	822	NUM
admet-1022	335	8	(	(	PUNCT
admet-1022	335	9	2015	2015	NUM
admet-1022	335	10	)	)	PUNCT
admet-1022	335	11	187	187	NUM
admet-1022	335	12	-	-	SYM
admet-1022	335	13	94	94	NUM
admet-1022	335	14	.	.	PUNCT
admet-1022	336	1	https://doi.org/10.1007/978-3-319-08927-0_21	https://doi.org/10.1007/978-3-319-08927-0_21	X
admet-1022	336	2	.	.	PUNCT
admet-1022	337	1	[	[	X
admet-1022	337	2	32	32	NUM
admet-1022	337	3	]	]	SYM
admet-1022	337	4	m.vieth	m.vieth	PROPN
admet-1022	337	5	,	,	PUNCT
admet-1022	337	6	j.j.sutherland	j.j.sutherland	NOUN
admet-1022	337	7	.	.	PUNCT
admet-1022	338	1	dependence	dependence	NOUN
admet-1022	338	2	of	of	ADP
admet-1022	338	3	molecular	molecular	ADJ
admet-1022	338	4	properties	property	NOUN
admet-1022	338	5	on	on	ADP
admet-1022	338	6	proteomic	proteomic	ADJ
admet-1022	338	7	family	family	NOUN
admet-1022	338	8	for	for	ADP
admet-1022	338	9	marketed	market	VERB
admet-1022	338	10	oral	oral	ADJ
admet-1022	338	11	drugs	drug	NOUN
admet-1022	338	12	.	.	PUNCT
admet-1022	339	1	journal	journal	NOUN
admet-1022	339	2	of	of	ADP
admet-1022	339	3	medicinal	medicinal	ADJ
admet-1022	339	4	chemistry	chemistry	NOUN
admet-1022	339	5	49	49	NUM
admet-1022	339	6	(	(	PUNCT
admet-1022	339	7	2006	2006	NUM
admet-1022	339	8	)	)	PUNCT
admet-1022	339	9	3451−3453	3451−3453	NUM
admet-1022	339	10	.	.	PUNCT
admet-1022	340	1	https://doi.org/10.1021/jm0603825	https://doi.org/10.1021/jm0603825	X
admet-1022	340	2	.	.	PUNCT
admet-1022	341	1	©	©	PROPN
admet-1022	341	2	2021	2021	NUM
admet-1022	341	3	by	by	ADP
admet-1022	341	4	the	the	DET
admet-1022	341	5	authors	author	NOUN
admet-1022	341	6	;	;	PUNCT
admet-1022	341	7	licensee	licensee	PROPN
admet-1022	341	8	iapc	iapc	PROPN
admet-1022	341	9	,	,	PUNCT
admet-1022	341	10	zagreb	zagreb	PROPN
admet-1022	341	11	,	,	PUNCT
admet-1022	341	12	croatia	croatia	PROPN
admet-1022	341	13	.	.	PUNCT
admet-1022	342	1	this	this	DET
admet-1022	342	2	article	article	NOUN
admet-1022	342	3	is	be	AUX
admet-1022	342	4	an	an	DET
admet-1022	342	5	open	open	ADJ
admet-1022	342	6	-	-	PUNCT
admet-1022	342	7	access	access	NOUN
admet-1022	342	8	article	article	NOUN
admet-1022	342	9	distributed	distribute	VERB
admet-1022	342	10	under	under	ADP
admet-1022	342	11	the	the	DET
admet-1022	342	12	terms	term	NOUN
admet-1022	342	13	and	and	CCONJ
admet-1022	342	14	conditions	condition	NOUN
admet-1022	342	15	of	of	ADP
admet-1022	342	16	the	the	DET
admet-1022	342	17	creative	creative	ADJ
admet-1022	342	18	commons	common	NOUN
admet-1022	342	19	attribution	attribution	NOUN
admet-1022	342	20	license	license	NOUN
admet-1022	342	21	(	(	PUNCT
admet-1022	342	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1022	342	23	)	)	PUNCT
admet-1022	342	24	https://www.tandfonline.com/toc/gsar20/current	https://www.tandfonline.com/toc/gsar20/current	PROPN
admet-1022	342	25	https://doi.org/10.1080/1062936x.2019.1653363	https://doi.org/10.1080/1062936x.2019.1653363	VERB
admet-1022	342	26	https://doi.org/10.1016/j.ejmech.2014.12.006	https://doi.org/10.1016/j.ejmech.2014.12.006	ADJ
admet-1022	342	27	https://doi.org/10.1248/cpb.40.127	https://doi.org/10.1248/cpb.40.127	NOUN
admet-1022	342	28	https://www.ncbi.nlm.nih.gov/pubmed/?term=montanari%20d%5bauthor%5d&cauthor=true&cauthor_uid=21358739	https://www.ncbi.nlm.nih.gov/pubmed/?term=montanari%20d%5bauthor%5d&cauthor=true&cauthor_uid=21358739	PROPN
admet-1022	342	29	https://www.ncbi.nlm.nih.gov/pubmed/?term=overington%20j%5bauthor%5d&cauthor=true&cauthor_uid=21358739	https://www.ncbi.nlm.nih.gov/pubmed/?term=overington%20j%5bauthor%5d&cauthor=true&cauthor_uid=21358739	X
admet-1022	343	1	https://doi.org/10.1038/nrd3367	https://doi.org/10.1038/nrd3367	X
admet-1022	344	1	http://www.ncbi.nlm.nih.gov/pubmed/?term=zhong%20ha%5bauthor%5d&cauthor=true&cauthor_uid=23675936	http://www.ncbi.nlm.nih.gov/pubmed/?term=zhong%20ha%5bauthor%5d&cauthor=true&cauthor_uid=23675936	INTJ
admet-1022	344	2	https://doi.org/10.2174/15680266113139990034	https://doi.org/10.2174/15680266113139990034	PRON
admet-1022	344	3	https://doi.org/10.1038/nrd3701	https://doi.org/10.1038/nrd3701	INTJ
admet-1022	345	1	https://doi.org/10.1021/acs.jmedchem.8b00686	https://doi.org/10.1021/acs.jmedchem.8b00686	PROPN
admet-1022	345	2	https://doi.org/10.1021/acs.jmedchem.8b00686	https://doi.org/10.1021/acs.jmedchem.8b00686	PROPN
admet-1022	345	3	https://pubmed.ncbi.nlm.nih.gov/25416989/	https://pubmed.ncbi.nlm.nih.gov/25416989/	PROPN
admet-1022	345	4	https://pubmed.ncbi.nlm.nih.gov/25416989/	https://pubmed.ncbi.nlm.nih.gov/25416989/	PROPN
admet-1022	345	5	https://doi.org/10.1007/978-3-319-08927-0_21	https://doi.org/10.1007/978-3-319-08927-0_21	PROPN
admet-1022	345	6	https://doi.org/10.1021/jm0603825	https://doi.org/10.1021/jm0603825	PRON
admet-1022	345	7	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN