id	sid	tid	token	lemma	pos
admet-1034	1	1	cδlog	cδlog	PROPN
admet-1034	1	2	kwiam	kwiam	PROPN
admet-1034	1	3	:	:	PUNCT
admet-1034	1	4	can	can	AUX
admet-1034	1	5	we	we	PRON
admet-1034	1	6	afford	afford	VERB
admet-1034	1	7	estimation	estimation	NOUN
admet-1034	1	8	of	of	ADP
admet-1034	1	9	small	small	ADJ
admet-1034	1	10	molecules	molecule	NOUN
admet-1034	1	11	’	'	PUNCT
admet-1034	1	12	blood	blood	NOUN
admet-1034	1	13	-	-	PUNCT
admet-1034	1	14	brain	brain	NOUN
admet-1034	1	15	barrier	barrier	NOUN
admet-1034	1	16	passage	passage	NOUN
admet-1034	1	17	based	base	VERB
admet-1034	1	18	upon	upon	SCONJ
admet-1034	1	19	in	in	ADP
admet-1034	1	20	silico	silico	NOUN
admet-1034	1	21	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	1	22	?	?	PUNCT
admet-1034	2	1	doi	doi	NOUN
admet-1034	2	2	:	:	PUNCT
admet-1034	2	3	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	2	4	267	267	NUM
admet-1034	2	5	admet	admet	X
admet-1034	2	6	&	&	CCONJ
admet-1034	2	7	dmpk	dmpk	PROPN
admet-1034	2	8	9(4	9(4	PROPN
admet-1034	2	9	)	)	PUNCT
admet-1034	2	10	(	(	PUNCT
admet-1034	2	11	2021	2021	NUM
admet-1034	2	12	)	)	PUNCT
admet-1034	2	13	267	267	NUM
admet-1034	2	14	-	-	SYM
admet-1034	2	15	281	281	NUM
admet-1034	2	16	;	;	PUNCT
admet-1034	2	17	doi	doi	NOUN
admet-1034	2	18	:	:	PUNCT
admet-1034	2	19	https://doi.org/10.5599/admet.1034	https://doi.org/10.5599/admet.1034	VERB
admet-1034	2	20	open	open	ADJ
admet-1034	2	21	access	access	NOUN
admet-1034	2	22	:	:	PUNCT
admet-1034	2	23	issn	issn	PROPN
admet-1034	2	24	:	:	PUNCT
admet-1034	2	25	1848	1848	NUM
admet-1034	2	26	-	-	SYM
admet-1034	2	27	7718	7718	NUM
admet-1034	2	28	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1034	2	29	original	original	ADJ
admet-1034	2	30	scientific	scientific	ADJ
admet-1034	2	31	paper	paper	NOUN
admet-1034	2	32	cδlog	cδlog	NOUN
admet-1034	2	33	kw	kw	PROPN
admet-1034	2	34	iam	iam	PROPN
admet-1034	2	35	:	:	PUNCT
admet-1034	2	36	can	can	AUX
admet-1034	2	37	we	we	PRON
admet-1034	2	38	afford	afford	VERB
admet-1034	2	39	estimation	estimation	NOUN
admet-1034	2	40	of	of	ADP
admet-1034	2	41	small	small	ADJ
admet-1034	2	42	molecules	molecule	NOUN
admet-1034	2	43	’	'	PUNCT
admet-1034	2	44	bloodbrain	bloodbrain	NOUN
admet-1034	2	45	barrier	barrier	NOUN
admet-1034	2	46	passage	passage	NOUN
admet-1034	2	47	based	base	VERB
admet-1034	2	48	upon	upon	SCONJ
admet-1034	2	49	in	in	ADP
admet-1034	2	50	silico	silico	NOUN
admet-1034	2	51	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	2	52	?	?	PUNCT
admet-1034	3	1	lucia	lucia	PROPN
admet-1034	3	2	grumetto1	grumetto1	PROPN
admet-1034	3	3	,	,	PUNCT
admet-1034	3	4	giacomo	giacomo	PROPN
admet-1034	3	5	russo2	russo2	PROPN
admet-1034	3	6	*	*	PROPN
admet-1034	3	7	1	1	NUM
admet-1034	3	8	pharm	pharm	NOUN
admet-1034	3	9	-	-	PUNCT
admet-1034	3	10	analysis	analysis	NOUN
admet-1034	3	11	&	&	CCONJ
admet-1034	3	12	bio	bio	PROPN
admet-1034	3	13	-	-	ADJ
admet-1034	3	14	pharm	pharm	ADJ
admet-1034	3	15	laboratory	laboratory	NOUN
admet-1034	3	16	,	,	PUNCT
admet-1034	3	17	department	department	NOUN
admet-1034	3	18	of	of	ADP
admet-1034	3	19	pharmacy	pharmacy	NOUN
admet-1034	3	20	,	,	PUNCT
admet-1034	3	21	school	school	NOUN
admet-1034	3	22	of	of	ADP
admet-1034	3	23	medicine	medicine	NOUN
admet-1034	3	24	and	and	CCONJ
admet-1034	3	25	surgery	surgery	NOUN
admet-1034	3	26	,	,	PUNCT
admet-1034	3	27	university	university	NOUN
admet-1034	3	28	of	of	ADP
admet-1034	3	29	naples	naples	PROPN
admet-1034	3	30	federico	federico	PROPN
admet-1034	3	31	ii	ii	PROPN
admet-1034	3	32	,	,	PUNCT
admet-1034	3	33	via	via	ADP
admet-1034	3	34	d.	d.	PROPN
admet-1034	3	35	montesano	montesano	PROPN
admet-1034	3	36	,	,	PUNCT
admet-1034	3	37	49	49	NUM
admet-1034	3	38	,	,	PUNCT
admet-1034	3	39	i-80131	i-80131	PROPN
admet-1034	3	40	,	,	PUNCT
admet-1034	3	41	naples	naples	PROPN
admet-1034	3	42	,	,	PUNCT
admet-1034	3	43	italy	italy	PROPN
admet-1034	3	44	.	.	PROPN
admet-1034	3	45	2	2	NUM
admet-1034	3	46	school	school	NOUN
admet-1034	3	47	of	of	ADP
admet-1034	3	48	applied	apply	VERB
admet-1034	3	49	sciences	science	NOUN
admet-1034	3	50	,	,	PUNCT
admet-1034	3	51	sighthill	sighthill	NOUN
admet-1034	3	52	campus	campus	PROPN
admet-1034	3	53	,	,	PUNCT
admet-1034	3	54	edinburgh	edinburgh	PROPN
admet-1034	3	55	napier	napier	PROPN
admet-1034	3	56	university	university	PROPN
admet-1034	3	57	,	,	PUNCT
admet-1034	3	58	9	9	NUM
admet-1034	3	59	sighthill	sighthill	NOUN
admet-1034	3	60	ct	ct	PROPN
admet-1034	3	61	,	,	PUNCT
admet-1034	3	62	eh11	eh11	PROPN
admet-1034	3	63	4bn	4bn	PROPN
admet-1034	3	64	edinburgh	edinburgh	PROPN
admet-1034	3	65	,	,	PUNCT
admet-1034	3	66	united	united	ADJ
admet-1034	3	67	kingdom	kingdom	PROPN
admet-1034	3	68	.	.	PUNCT
admet-1034	4	1	*	*	PUNCT
admet-1034	4	2	corresponding	correspond	VERB
admet-1034	4	3	author	author	NOUN
admet-1034	4	4	:	:	PUNCT
admet-1034	4	5	e	e	NOUN
admet-1034	4	6	-	-	NOUN
admet-1034	4	7	mail	mail	NOUN
admet-1034	4	8	:	:	PUNCT
admet-1034	4	9	g.russo@napier.ac.uk	g.russo@napier.ac.uk	VERB
admet-1034	4	10	;	;	PUNCT
admet-1034	4	11	tel	tel	PROPN
admet-1034	4	12	.	.	PUNCT
admet-1034	4	13	:	:	PUNCT
admet-1034	4	14	+44	+44	PROPN
admet-1034	4	15	(	(	PUNCT
admet-1034	4	16	0	0	NUM
admet-1034	4	17	)	)	PUNCT
admet-1034	4	18	131	131	NUM
admet-1034	4	19	455	455	NUM
admet-1034	4	20	3464	3464	NUM
admet-1034	4	21	;	;	PUNCT
admet-1034	4	22	fax	fax	NOUN
admet-1034	4	23	:	:	PUNCT
admet-1034	4	24	+44	+44	PROPN
admet-1034	4	25	(	(	PUNCT
admet-1034	4	26	0	0	NUM
admet-1034	4	27	)	)	PUNCT
admet-1034	4	28	131	131	NUM
admet-1034	4	29	455	455	NUM
admet-1034	4	30	3555	3555	NUM
admet-1034	4	31	received	receive	VERB
admet-1034	4	32	:	:	PUNCT
admet-1034	4	33	june	june	PROPN
admet-1034	4	34	27	27	NUM
admet-1034	4	35	,	,	PUNCT
admet-1034	4	36	2021	2021	NUM
admet-1034	4	37	;	;	PUNCT
admet-1034	4	38	revised	revise	VERB
admet-1034	4	39	:	:	PUNCT
admet-1034	4	40	november	november	PROPN
admet-1034	4	41	27	27	NUM
admet-1034	4	42	,	,	PUNCT
admet-1034	4	43	2021	2021	NUM
admet-1034	4	44	;	;	PUNCT
admet-1034	4	45	published	publish	VERB
admet-1034	4	46	:	:	PUNCT
admet-1034	4	47	december	december	PROPN
admet-1034	4	48	15	15	NUM
admet-1034	4	49	,	,	PUNCT
admet-1034	4	50	2021	2021	NUM
admet-1034	4	51	abstract	abstract	ADJ
admet-1034	4	52	56	56	NUM
admet-1034	4	53	compounds	compound	NOUN
admet-1034	4	54	,	,	PUNCT
admet-1034	4	55	whose	whose	DET
admet-1034	4	56	log	log	NOUN
admet-1034	4	57	bb	bb	NOUN
admet-1034	4	58	values	value	NOUN
admet-1034	4	59	were	be	AUX
admet-1034	4	60	known	know	VERB
admet-1034	4	61	from	from	ADP
admet-1034	4	62	the	the	DET
admet-1034	4	63	scientific	scientific	ADJ
admet-1034	4	64	literature	literature	NOUN
admet-1034	4	65	,	,	PUNCT
admet-1034	4	66	were	be	AUX
admet-1034	4	67	considered	consider	VERB
admet-1034	4	68	and	and	CCONJ
admet-1034	4	69	their	their	PRON
admet-1034	4	70	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	4	71	values	value	NOUN
admet-1034	4	72	were	be	AUX
admet-1034	4	73	calculated	calculate	VERB
admet-1034	4	74	in	in	ADP
admet-1034	4	75	silico	silico	NOUN
admet-1034	4	76	.	.	PUNCT
admet-1034	5	1	these	these	DET
admet-1034	5	2	values	value	NOUN
admet-1034	5	3	,	,	PUNCT
admet-1034	5	4	along	along	ADP
admet-1034	5	5	with	with	ADP
admet-1034	5	6	either	either	CCONJ
admet-1034	5	7	experimentally	experimentally	ADV
admet-1034	5	8	determined	determine	VERB
admet-1034	5	9	or	or	CCONJ
admet-1034	5	10	calculated	calculate	VERB
admet-1034	5	11	lipophilicity	lipophilicity	NOUN
admet-1034	5	12	values	value	NOUN
admet-1034	5	13	,	,	PUNCT
admet-1034	5	14	were	be	AUX
admet-1034	5	15	used	use	VERB
admet-1034	5	16	to	to	PART
admet-1034	5	17	extract	extract	VERB
admet-1034	5	18	cδ	cδ	NOUN
admet-1034	5	19	/	/	SYM
admet-1034	5	20	δ’log	δ’log	NOUN
admet-1034	5	21	kw	kw	PROPN
admet-1034	5	22	iam	iam	PROPN
admet-1034	5	23	parameters	parameter	NOUN
admet-1034	5	24	.	.	PUNCT
admet-1034	6	1	cδ	cδ	VERB
admet-1034	6	2	/	/	SYM
admet-1034	6	3	δ’log	δ’log	NOUN
admet-1034	6	4	kw	kw	PROPN
admet-1034	6	5	iam	iam	PROPN
admet-1034	6	6	values	value	NOUN
admet-1034	6	7	were	be	AUX
admet-1034	6	8	found	find	VERB
admet-1034	6	9	inversely	inversely	ADV
admet-1034	6	10	related	relate	VERB
admet-1034	6	11	to	to	ADP
admet-1034	6	12	data	datum	NOUN
admet-1034	6	13	of	of	ADP
admet-1034	6	14	blood	blood	NOUN
admet-1034	6	15	-	-	PUNCT
admet-1034	6	16	brain	brain	NOUN
admet-1034	6	17	barrier	barrier	NOUN
admet-1034	6	18	passage	passage	NOUN
admet-1034	6	19	,	,	PUNCT
admet-1034	6	20	especially	especially	ADV
admet-1034	6	21	in	in	ADP
admet-1034	6	22	the	the	DET
admet-1034	6	23	<	<	X
admet-1034	6	24	-0.20	-0.20	NUM
admet-1034	6	25	log	log	NOUN
admet-1034	6	26	bb	bb	NUM
admet-1034	6	27	range	range	NOUN
admet-1034	6	28	and	and	CCONJ
admet-1034	6	29	on	on	ADP
admet-1034	6	30	the	the	DET
admet-1034	6	31	iam.pc.dd2	iam.pc.dd2	PROPN
admet-1034	6	32	phase	phase	NOUN
admet-1034	6	33	(	(	PUNCT
admet-1034	6	34	r	r	NOUN
admet-1034	6	35	2	2	NUM
admet-1034	6	36	=	=	SYM
admet-1034	6	37	0.79	0.79	NUM
admet-1034	6	38	)	)	PUNCT
admet-1034	6	39	.	.	PUNCT
admet-1034	7	1	in	in	ADP
admet-1034	7	2	multiple	multiple	ADJ
admet-1034	7	3	linear	linear	PROPN
admet-1034	7	4	regression	regression	NOUN
admet-1034	7	5	,	,	PUNCT
admet-1034	7	6	satisfactory	satisfactory	ADJ
admet-1034	7	7	statistic	statistic	NOUN
admet-1034	7	8	models	model	NOUN
admet-1034	7	9	(	(	PUNCT
admet-1034	7	10	r	r	NOUN
admet-1034	7	11	2	2	NUM
admet-1034	7	12	(	(	PUNCT
admet-1034	7	13	n-1	n-1	NUM
admet-1034	7	14	)	)	PUNCT
admet-1034	7	15	=	=	SYM
admet-1034	7	16	0.76	0.76	NUM
admet-1034	7	17	)	)	PUNCT
admet-1034	7	18	,	,	PUNCT
admet-1034	7	19	based	base	VERB
admet-1034	7	20	on	on	ADP
admet-1034	7	21	c/’log	c/’log	PROPN
admet-1034	7	22	kw	kw	PRON
admet-1034	7	23	iam.mg	iam.mg	PROPN
admet-1034	7	24	along	along	ADP
admet-1034	7	25	with	with	ADP
admet-1034	7	26	other	other	ADJ
admet-1034	7	27	in	in	ADP
admet-1034	7	28	silico	silico	NOUN
admet-1034	7	29	calculated	calculate	VERB
admet-1034	7	30	descriptors	descriptor	NOUN
admet-1034	7	31	,	,	PUNCT
admet-1034	7	32	were	be	AUX
admet-1034	7	33	achieved	achieve	VERB
admet-1034	7	34	.	.	PUNCT
admet-1034	8	1	this	this	DET
admet-1034	8	2	method	method	NOUN
admet-1034	8	3	brings	bring	VERB
admet-1034	8	4	the	the	DET
admet-1034	8	5	potential	potential	NOUN
admet-1034	8	6	to	to	PART
admet-1034	8	7	be	be	AUX
admet-1034	8	8	applied	apply	VERB
admet-1034	8	9	,	,	PUNCT
admet-1034	8	10	along	along	ADP
admet-1034	8	11	with	with	ADP
admet-1034	8	12	other	other	ADJ
admet-1034	8	13	methodologies	methodology	NOUN
admet-1034	8	14	,	,	PUNCT
admet-1034	8	15	to	to	PART
admet-1034	8	16	filter	filter	VERB
admet-1034	8	17	out	out	ADP
admet-1034	8	18	solutes	solute	NOUN
admet-1034	8	19	whose	whose	DET
admet-1034	8	20	bbb	bbb	NOUN
admet-1034	8	21	permeation	permeation	NOUN
admet-1034	8	22	is	be	AUX
admet-1034	8	23	foreseen	foresee	VERB
admet-1034	8	24	to	to	PART
admet-1034	8	25	be	be	AUX
admet-1034	8	26	substandard	substandard	ADJ
admet-1034	8	27	,	,	PUNCT
admet-1034	8	28	thus	thus	ADV
admet-1034	8	29	allowing	allow	VERB
admet-1034	8	30	pharmaceutical	pharmaceutical	ADJ
admet-1034	8	31	companies	company	NOUN
admet-1034	8	32	/	/	SYM
admet-1034	8	33	research	research	NOUN
admet-1034	8	34	institutes	institute	NOUN
admet-1034	8	35	to	to	PART
admet-1034	8	36	focus	focus	VERB
admet-1034	8	37	on	on	ADP
admet-1034	8	38	candidates	candidate	NOUN
admet-1034	8	39	that	that	PRON
admet-1034	8	40	are	be	AUX
admet-1034	8	41	more	more	ADV
admet-1034	8	42	likely	likely	ADJ
admet-1034	8	43	to	to	PART
admet-1034	8	44	concentrate	concentrate	VERB
admet-1034	8	45	in	in	ADP
admet-1034	8	46	the	the	DET
admet-1034	8	47	brain	brain	NOUN
admet-1034	8	48	.	.	PUNCT
admet-1034	9	1	©	©	NOUN
admet-1034	9	2	2021	2021	NUM
admet-1034	9	3	by	by	ADP
admet-1034	9	4	the	the	DET
admet-1034	9	5	authors	author	NOUN
admet-1034	9	6	.	.	PUNCT
admet-1034	10	1	this	this	DET
admet-1034	10	2	article	article	NOUN
admet-1034	10	3	is	be	AUX
admet-1034	10	4	an	an	DET
admet-1034	10	5	open	open	ADJ
admet-1034	10	6	-	-	PUNCT
admet-1034	10	7	access	access	NOUN
admet-1034	10	8	article	article	NOUN
admet-1034	10	9	distributed	distribute	VERB
admet-1034	10	10	under	under	ADP
admet-1034	10	11	the	the	DET
admet-1034	10	12	terms	term	NOUN
admet-1034	10	13	and	and	CCONJ
admet-1034	10	14	conditions	condition	NOUN
admet-1034	10	15	of	of	ADP
admet-1034	10	16	the	the	DET
admet-1034	10	17	creative	creative	ADJ
admet-1034	10	18	commons	common	NOUN
admet-1034	10	19	attribution	attribution	NOUN
admet-1034	10	20	license	license	NOUN
admet-1034	10	21	(	(	PUNCT
admet-1034	10	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1034	10	23	)	)	PUNCT
admet-1034	10	24	.	.	PUNCT
admet-1034	11	1	keywords	keyword	NOUN
admet-1034	11	2	immobilized	immobilize	VERB
admet-1034	11	3	artificial	artificial	ADJ
admet-1034	11	4	membrane	membrane	NOUN
admet-1034	11	5	;	;	PUNCT
admet-1034	11	6	biochromatography	biochromatography	NOUN
admet-1034	11	7	;	;	PUNCT
admet-1034	11	8	blood	blood	NOUN
admet-1034	11	9	brain	brain	NOUN
admet-1034	11	10	barrier	barrier	NOUN
admet-1034	11	11	;	;	PUNCT
admet-1034	11	12	brain	brain	NOUN
admet-1034	11	13	targeting	targeting	NOUN
admet-1034	11	14	;	;	PUNCT
admet-1034	11	15	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	11	16	.	.	PUNCT
admet-1034	12	1	introduction	introduction	NOUN
admet-1034	12	2	combinatorial	combinatorial	ADJ
admet-1034	12	3	chemistry	chemistry	NOUN
admet-1034	12	4	involves	involve	VERB
admet-1034	12	5	the	the	DET
admet-1034	12	6	generation	generation	NOUN
admet-1034	12	7	of	of	ADP
admet-1034	12	8	a	a	DET
admet-1034	12	9	large	large	ADJ
admet-1034	12	10	array	array	NOUN
admet-1034	12	11	of	of	ADP
admet-1034	12	12	structurally	structurally	ADV
admet-1034	12	13	diverse	diverse	ADJ
admet-1034	12	14	compounds	compound	NOUN
admet-1034	12	15	,	,	PUNCT
admet-1034	12	16	i.e.	i.e.	X
admet-1034	12	17	,	,	PUNCT
admet-1034	12	18	a	a	DET
admet-1034	12	19	chemical	chemical	NOUN
admet-1034	12	20	library	library	NOUN
admet-1034	12	21	,	,	PUNCT
admet-1034	12	22	through	through	ADP
admet-1034	12	23	systematic	systematic	ADJ
admet-1034	12	24	,	,	PUNCT
admet-1034	12	25	repetitive	repetitive	ADJ
admet-1034	12	26	and	and	CCONJ
admet-1034	12	27	covalent	covalent	ADJ
admet-1034	12	28	linkage	linkage	NOUN
admet-1034	12	29	of	of	ADP
admet-1034	12	30	various	various	ADJ
admet-1034	12	31	“	"	PUNCT
admet-1034	12	32	building	building	NOUN
admet-1034	12	33	blocks	block	NOUN
admet-1034	12	34	”	"	PUNCT
admet-1034	13	1	[	[	X
admet-1034	13	2	1	1	NUM
admet-1034	13	3	]	]	PUNCT
admet-1034	13	4	.	.	PUNCT
admet-1034	14	1	this	this	DET
admet-1034	14	2	technique	technique	NOUN
admet-1034	14	3	can	can	AUX
admet-1034	14	4	be	be	AUX
admet-1034	14	5	exploited	exploit	VERB
admet-1034	14	6	in	in	ADP
admet-1034	14	7	parallel	parallel	NOUN
admet-1034	14	8	,	,	PUNCT
admet-1034	14	9	delivering	deliver	VERB
admet-1034	14	10	hundreds	hundred	NOUN
admet-1034	14	11	,	,	PUNCT
admet-1034	14	12	if	if	SCONJ
admet-1034	14	13	not	not	PART
admet-1034	14	14	thousands	thousand	NOUN
admet-1034	14	15	,	,	PUNCT
admet-1034	14	16	of	of	ADP
admet-1034	14	17	molecules	molecule	NOUN
admet-1034	14	18	of	of	ADP
admet-1034	14	19	pharmaceutical	pharmaceutical	ADJ
admet-1034	14	20	interest	interest	NOUN
admet-1034	14	21	in	in	ADP
admet-1034	14	22	a	a	DET
admet-1034	14	23	handful	handful	NOUN
admet-1034	14	24	of	of	ADP
admet-1034	14	25	hours	hour	NOUN
admet-1034	14	26	.	.	PUNCT
admet-1034	15	1	while	while	SCONJ
admet-1034	15	2	the	the	DET
admet-1034	15	3	organic	organic	ADJ
admet-1034	15	4	synthesis	synthesis	NOUN
admet-1034	15	5	throughput	throughput	NOUN
admet-1034	15	6	has	have	AUX
admet-1034	15	7	expanded	expand	VERB
admet-1034	15	8	so	so	ADV
admet-1034	15	9	noticeably	noticeably	ADV
admet-1034	15	10	in	in	ADP
admet-1034	15	11	recent	recent	ADJ
admet-1034	15	12	years	year	NOUN
admet-1034	15	13	,	,	PUNCT
admet-1034	15	14	screening	screen	VERB
admet-1034	15	15	methodologies	methodology	NOUN
admet-1034	15	16	are	be	AUX
admet-1034	15	17	still	still	ADV
admet-1034	15	18	lagging	lag	VERB
admet-1034	15	19	behind	behind	ADV
admet-1034	15	20	,	,	PUNCT
admet-1034	15	21	instead	instead	ADV
admet-1034	15	22	[	[	X
admet-1034	15	23	2	2	NUM
admet-1034	15	24	]	]	PUNCT
admet-1034	15	25	.	.	PUNCT
admet-1034	16	1	indeed	indeed	ADV
admet-1034	16	2	,	,	PUNCT
admet-1034	16	3	most	most	ADJ
admet-1034	16	4	of	of	ADP
admet-1034	16	5	the	the	DET
admet-1034	16	6	testing	testing	NOUN
admet-1034	16	7	still	still	ADV
admet-1034	16	8	requires	require	VERB
admet-1034	16	9	animal	animal	NOUN
admet-1034	16	10	models	model	NOUN
admet-1034	16	11	that	that	PRON
admet-1034	16	12	have	have	VERB
admet-1034	16	13	the	the	DET
admet-1034	16	14	undeniable	undeniable	ADJ
admet-1034	16	15	advantage	advantage	NOUN
admet-1034	16	16	of	of	ADP
admet-1034	16	17	mirroring	mirror	VERB
admet-1034	16	18	more	more	ADV
admet-1034	16	19	closely	closely	ADV
admet-1034	16	20	the	the	DET
admet-1034	16	21	complexity	complexity	NOUN
admet-1034	16	22	of	of	ADP
admet-1034	16	23	human	human	ADJ
admet-1034	16	24	beings	being	NOUN
admet-1034	16	25	than	than	ADP
admet-1034	16	26	cells	cell	NOUN
admet-1034	16	27	.	.	PUNCT
admet-1034	17	1	however	however	ADV
admet-1034	17	2	,	,	PUNCT
admet-1034	17	3	animal	animal	NOUN
admet-1034	17	4	models	model	NOUN
admet-1034	17	5	are	be	AUX
admet-1034	17	6	facing	face	VERB
admet-1034	17	7	criticism	criticism	NOUN
admet-1034	17	8	from	from	ADP
admet-1034	17	9	the	the	DET
admet-1034	17	10	public	public	NOUN
admet-1034	17	11	since	since	SCONJ
admet-1034	17	12	they	they	PRON
admet-1034	17	13	often	often	ADV
admet-1034	17	14	require	require	VERB
admet-1034	17	15	the	the	DET
admet-1034	17	16	sacrifice	sacrifice	NOUN
admet-1034	17	17	of	of	ADP
admet-1034	17	18	vertebrates	vertebrate	NOUN
admet-1034	17	19	[	[	X
admet-1034	17	20	3	3	NUM
admet-1034	17	21	]	]	PUNCT
admet-1034	17	22	and	and	CCONJ
admet-1034	17	23	heavily	heavily	ADV
admet-1034	17	24	impact	impact	VERB
admet-1034	17	25	the	the	DET
admet-1034	17	26	environment	environment	NOUN
admet-1034	17	27	due	due	ADP
admet-1034	17	28	to	to	ADP
admet-1034	17	29	the	the	DET
admet-1034	17	30	huge	huge	ADJ
admet-1034	17	31	number	number	NOUN
admet-1034	17	32	of	of	ADP
admet-1034	17	33	carcasses	carcass	NOUN
admet-1034	17	34	to	to	PART
admet-1034	17	35	dispose	dispose	VERB
admet-1034	17	36	of	of	ADP
admet-1034	17	37	.	.	PUNCT
admet-1034	18	1	the	the	DET
admet-1034	18	2	assessment	assessment	NOUN
admet-1034	18	3	of	of	ADP
admet-1034	18	4	the	the	DET
admet-1034	18	5	ability	ability	NOUN
admet-1034	18	6	of	of	ADP
admet-1034	18	7	a	a	DET
admet-1034	18	8	drug	drug	NOUN
admet-1034	18	9	to	to	PART
admet-1034	18	10	cross	cross	VERB
admet-1034	18	11	the	the	DET
admet-1034	18	12	biological	biological	ADJ
admet-1034	18	13	membranes	membrane	NOUN
admet-1034	18	14	in	in	ADP
admet-1034	18	15	the	the	DET
admet-1034	18	16	early	early	ADJ
admet-1034	18	17	stages	stage	NOUN
admet-1034	18	18	of	of	ADP
admet-1034	18	19	its	its	PRON
admet-1034	18	20	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	ADJ
admet-1034	18	21	https://doi.org/10.5599/admet.1034	https://doi.org/10.5599/admet.1034	NOUN
admet-1034	18	22	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1034	18	23	mailto:g.russo@napier.ac.uk	mailto:g.russo@napier.ac.uk	X
admet-1034	18	24	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1034	18	25	grumetto	grumetto	PROPN
admet-1034	18	26	and	and	CCONJ
admet-1034	18	27	russo	russo	PROPN
admet-1034	18	28	admet	admet	PROPN
admet-1034	18	29	&	&	CCONJ
admet-1034	18	30	dmpk	dmpk	PROPN
admet-1034	18	31	9(4	9(4	PROPN
admet-1034	18	32	)	)	PUNCT
admet-1034	18	33	(	(	PUNCT
admet-1034	18	34	2021	2021	NUM
admet-1034	18	35	)	)	PUNCT
admet-1034	19	1	267	267	NUM
admet-1034	19	2	-	-	SYM
admet-1034	19	3	281	281	NUM
admet-1034	19	4	268	268	NUM
admet-1034	19	5	development	development	NOUN
admet-1034	19	6	plays	play	VERB
admet-1034	19	7	a	a	DET
admet-1034	19	8	pivotal	pivotal	ADJ
admet-1034	19	9	role	role	NOUN
admet-1034	19	10	in	in	ADP
admet-1034	19	11	pharmaceutical	pharmaceutical	ADJ
admet-1034	19	12	industrial	industrial	ADJ
admet-1034	19	13	research	research	NOUN
admet-1034	19	14	.	.	PUNCT
admet-1034	20	1	notably	notably	ADV
admet-1034	20	2	,	,	PUNCT
admet-1034	20	3	the	the	DET
admet-1034	20	4	development	development	NOUN
admet-1034	20	5	of	of	ADP
admet-1034	20	6	drugs	drug	NOUN
admet-1034	20	7	acting	act	VERB
admet-1034	20	8	toward	toward	ADP
admet-1034	20	9	the	the	DET
admet-1034	20	10	central	central	ADJ
admet-1034	20	11	nervous	nervous	ADJ
admet-1034	20	12	system	system	NOUN
admet-1034	20	13	(	(	PUNCT
admet-1034	20	14	cns	cns	NOUN
admet-1034	20	15	)	)	PUNCT
admet-1034	20	16	has	have	VERB
admet-1034	20	17	poorer	poor	ADJ
admet-1034	20	18	success	success	NOUN
admet-1034	20	19	rates	rate	NOUN
admet-1034	20	20	and	and	CCONJ
admet-1034	20	21	requires	require	VERB
admet-1034	20	22	longer	long	ADJ
admet-1034	20	23	times	time	NOUN
admet-1034	20	24	than	than	ADP
admet-1034	20	25	non	non	ADJ
admet-1034	20	26	-	-	ADJ
admet-1034	20	27	cns	cns	ADJ
admet-1034	20	28	drugs	drug	NOUN
admet-1034	20	29	[	[	X
admet-1034	20	30	4	4	NUM
admet-1034	20	31	]	]	PUNCT
admet-1034	20	32	.	.	PUNCT
admet-1034	21	1	this	this	PRON
admet-1034	21	2	occurs	occur	VERB
admet-1034	21	3	due	due	ADP
admet-1034	21	4	to	to	ADP
admet-1034	21	5	the	the	DET
admet-1034	21	6	complexity	complexity	NOUN
admet-1034	21	7	of	of	ADP
admet-1034	21	8	the	the	DET
admet-1034	21	9	blood	blood	NOUN
admet-1034	21	10	-	-	PUNCT
admet-1034	21	11	brain	brain	NOUN
admet-1034	21	12	barrier	barrier	NOUN
admet-1034	21	13	(	(	PUNCT
admet-1034	21	14	bbb	bbb	NOUN
admet-1034	21	15	)	)	PUNCT
admet-1034	21	16	.	.	PUNCT
admet-1034	22	1	in	in	ADP
admet-1034	22	2	fact	fact	NOUN
admet-1034	22	3	,	,	PUNCT
admet-1034	22	4	in	in	ADP
admet-1034	22	5	a	a	DET
admet-1034	22	6	healthy	healthy	ADJ
admet-1034	22	7	brain	brain	NOUN
admet-1034	22	8	,	,	PUNCT
admet-1034	22	9	the	the	DET
admet-1034	22	10	bbb	bbb	PROPN
admet-1034	22	11	plays	play	VERB
admet-1034	22	12	a	a	DET
admet-1034	22	13	crucial	crucial	ADJ
admet-1034	22	14	role	role	NOUN
admet-1034	22	15	in	in	ADP
admet-1034	22	16	protecting	protect	VERB
admet-1034	22	17	normal	normal	ADJ
admet-1034	22	18	brain	brain	NOUN
admet-1034	22	19	functions	function	NOUN
admet-1034	22	20	from	from	ADP
admet-1034	22	21	potentially	potentially	ADV
admet-1034	22	22	harmful	harmful	ADJ
admet-1034	22	23	compounds	compound	NOUN
admet-1034	22	24	occurring	occur	VERB
admet-1034	22	25	in	in	ADP
admet-1034	22	26	the	the	DET
admet-1034	22	27	bloodstream	bloodstream	NOUN
admet-1034	22	28	[	[	X
admet-1034	22	29	5	5	NUM
admet-1034	22	30	]	]	PUNCT
admet-1034	22	31	.	.	PUNCT
admet-1034	23	1	strategies	strategy	NOUN
admet-1034	23	2	for	for	ADP
admet-1034	23	3	brain	brain	NOUN
admet-1034	23	4	drug	drug	NOUN
admet-1034	23	5	delivery	delivery	NOUN
admet-1034	23	6	have	have	AUX
admet-1034	23	7	developed	develop	VERB
admet-1034	23	8	in	in	ADP
admet-1034	23	9	the	the	DET
admet-1034	23	10	last	last	ADJ
admet-1034	23	11	decades	decade	NOUN
admet-1034	23	12	,	,	PUNCT
admet-1034	23	13	and	and	CCONJ
admet-1034	23	14	various	various	ADJ
admet-1034	23	15	techniques	technique	NOUN
admet-1034	23	16	are	be	AUX
admet-1034	23	17	available	available	ADJ
admet-1034	23	18	to	to	PART
admet-1034	23	19	study	study	VERB
admet-1034	23	20	the	the	DET
admet-1034	23	21	bbb	bbb	PROPN
admet-1034	23	22	's	's	PART
admet-1034	23	23	role	role	NOUN
admet-1034	23	24	in	in	ADP
admet-1034	23	25	drug	drug	NOUN
admet-1034	23	26	uptake	uptake	NOUN
admet-1034	23	27	.	.	PUNCT
admet-1034	24	1	these	these	PRON
admet-1034	24	2	include	include	VERB
admet-1034	24	3	in	in	ADP
admet-1034	24	4	vivo	vivo	NOUN
admet-1034	24	5	,	,	PUNCT
admet-1034	24	6	in	in	ADP
admet-1034	24	7	vitro	vitro	X
admet-1034	24	8	[	[	X
admet-1034	24	9	6	6	NUM
admet-1034	24	10	]	]	PUNCT
admet-1034	24	11	and	and	CCONJ
admet-1034	24	12	in	in	ADP
admet-1034	24	13	situ	situ	ADJ
admet-1034	24	14	techniques	technique	NOUN
admet-1034	24	15	[	[	X
admet-1034	24	16	7	7	NUM
admet-1034	24	17	]	]	PUNCT
admet-1034	24	18	.	.	PUNCT
admet-1034	25	1	separation	separation	NOUN
admet-1034	25	2	science	science	NOUN
admet-1034	25	3	offers	offer	VERB
admet-1034	25	4	valuable	valuable	ADJ
admet-1034	25	5	alternatives	alternative	NOUN
admet-1034	25	6	to	to	ADP
admet-1034	25	7	animal	animal	NOUN
admet-1034	25	8	testing	testing	NOUN
admet-1034	25	9	that	that	PRON
admet-1034	25	10	can	can	AUX
admet-1034	25	11	provide	provide	VERB
admet-1034	25	12	effectiveness	effectiveness	NOUN
admet-1034	25	13	in	in	ADP
admet-1034	25	14	the	the	DET
admet-1034	25	15	drug	drug	NOUN
admet-1034	25	16	discovery	discovery	NOUN
admet-1034	25	17	/	/	SYM
admet-1034	25	18	drug	drug	NOUN
admet-1034	25	19	development	development	NOUN
admet-1034	25	20	pipeline	pipeline	NOUN
admet-1034	25	21	as	as	ADP
admet-1034	25	22	biomimetic	biomimetic	ADJ
admet-1034	25	23	liquid	liquid	ADJ
admet-1034	25	24	chromatography	chromatography	NOUN
admet-1034	25	25	[	[	X
admet-1034	25	26	8	8	NUM
admet-1034	25	27	-	-	SYM
admet-1034	25	28	11	11	NUM
admet-1034	25	29	]	]	PUNCT
admet-1034	25	30	,	,	PUNCT
admet-1034	25	31	performed	perform	VERB
admet-1034	25	32	employing	employ	VERB
admet-1034	25	33	stationary	stationary	ADJ
admet-1034	25	34	phases	phase	NOUN
admet-1034	25	35	emulating	emulate	VERB
admet-1034	25	36	biological	biological	ADJ
admet-1034	25	37	components	component	NOUN
admet-1034	25	38	or	or	CCONJ
admet-1034	25	39	using	use	VERB
admet-1034	25	40	mobile	mobile	ADJ
admet-1034	25	41	phase	phase	NOUN
admet-1034	25	42	ingredients	ingredient	NOUN
admet-1034	25	43	simulating	simulate	VERB
admet-1034	25	44	physiological	physiological	ADJ
admet-1034	25	45	environments	environment	NOUN
admet-1034	25	46	.	.	PUNCT
admet-1034	26	1	a	a	DET
admet-1034	26	2	consistent	consistent	ADJ
admet-1034	26	3	branch	branch	NOUN
admet-1034	26	4	of	of	ADP
admet-1034	26	5	this	this	PRON
admet-1034	26	6	is	be	AUX
admet-1034	26	7	represented	represent	VERB
admet-1034	26	8	by	by	ADP
admet-1034	26	9	liquid	liquid	ADJ
admet-1034	26	10	chromatography	chromatography	NOUN
admet-1034	26	11	(	(	PUNCT
admet-1034	26	12	lc	lc	PROPN
admet-1034	26	13	)	)	PUNCT
admet-1034	26	14	conducted	conduct	VERB
admet-1034	26	15	on	on	ADP
admet-1034	26	16	stationary	stationary	ADJ
admet-1034	26	17	phases	phase	NOUN
admet-1034	26	18	based	base	VERB
admet-1034	26	19	on	on	ADP
admet-1034	26	20	immobilized	immobilized	ADJ
admet-1034	26	21	artificial	artificial	ADJ
admet-1034	26	22	membranes	membrane	NOUN
admet-1034	26	23	(	(	PUNCT
admet-1034	26	24	iam	iam	PROPN
admet-1034	26	25	)	)	PUNCT
admet-1034	26	26	.	.	PUNCT
admet-1034	27	1	iam	iam	PROPN
admet-1034	27	2	phases	phase	NOUN
admet-1034	27	3	are	be	AUX
admet-1034	27	4	based	base	VERB
admet-1034	27	5	on	on	ADP
admet-1034	27	6	membrane	membrane	NOUN
admet-1034	27	7	phospholipid	phospholipid	NOUN
admet-1034	27	8	analogs	analog	NOUN
admet-1034	27	9	covalently	covalently	ADV
admet-1034	27	10	bound	bind	VERB
admet-1034	27	11	to	to	ADP
admet-1034	27	12	aminopropyl	aminopropyl	PROPN
admet-1034	27	13	silica	silica	NOUN
admet-1034	27	14	[	[	X
admet-1034	27	15	7,12,13	7,12,13	NUM
admet-1034	27	16	]	]	PUNCT
admet-1034	27	17	.	.	PUNCT
admet-1034	28	1	some	some	PRON
admet-1034	28	2	of	of	ADP
admet-1034	28	3	these	these	DET
admet-1034	28	4	phases	phase	NOUN
admet-1034	28	5	are	be	AUX
admet-1034	28	6	available	available	ADJ
admet-1034	28	7	commercially	commercially	ADV
admet-1034	28	8	as	as	ADP
admet-1034	28	9	iam.pc.mg	iam.pc.mg	PROPN
admet-1034	28	10	and	and	CCONJ
admet-1034	28	11	iam.pc.dd2	iam.pc.dd2	PROPN
admet-1034	28	12	.	.	PUNCT
admet-1034	29	1	both	both	DET
admet-1034	29	2	these	these	DET
admet-1034	29	3	support	support	NOUN
admet-1034	29	4	phosphatidylcholine	phosphatidylcholine	NOUN
admet-1034	29	5	analogs	analog	NOUN
admet-1034	29	6	(	(	PUNCT
admet-1034	29	7	pc	pc	NOUN
admet-1034	29	8	)	)	PUNCT
admet-1034	29	9	,	,	PUNCT
admet-1034	29	10	but	but	CCONJ
admet-1034	29	11	they	they	PRON
admet-1034	29	12	differ	differ	VERB
admet-1034	29	13	from	from	ADP
admet-1034	29	14	each	each	DET
admet-1034	29	15	other	other	ADJ
admet-1034	29	16	in	in	ADP
admet-1034	29	17	the	the	DET
admet-1034	29	18	end	end	NOUN
admet-1034	29	19	-	-	PUNCT
admet-1034	29	20	capping	capping	NOUN
admet-1034	29	21	of	of	ADP
admet-1034	29	22	the	the	DET
admet-1034	29	23	free	free	ADJ
admet-1034	29	24	aminopropyl	aminopropyl	PROPN
admet-1034	29	25	moieties	moiety	NOUN
admet-1034	29	26	,	,	PUNCT
admet-1034	29	27	which	which	PRON
admet-1034	29	28	is	be	AUX
admet-1034	29	29	performed	perform	VERB
admet-1034	29	30	with	with	ADP
admet-1034	29	31	methyl	methyl	NOUN
admet-1034	29	32	glycolate	glycolate	NOUN
admet-1034	29	33	(	(	PUNCT
admet-1034	29	34	mg	mg	PROPN
admet-1034	29	35	)	)	PUNCT
admet-1034	29	36	or	or	CCONJ
admet-1034	29	37	with	with	ADP
admet-1034	29	38	c3	c3	PROPN
admet-1034	29	39	or	or	CCONJ
admet-1034	29	40	c10	c10	PROPN
admet-1034	29	41	anhydrides	anhydride	NOUN
admet-1034	29	42	(	(	PUNCT
admet-1034	29	43	dd2	dd2	PROPN
admet-1034	29	44	)	)	PUNCT
admet-1034	29	45	.	.	PUNCT
admet-1034	30	1	in	in	ADP
admet-1034	30	2	recent	recent	ADJ
admet-1034	30	3	years	year	NOUN
admet-1034	30	4	,	,	PUNCT
admet-1034	30	5	we	we	PRON
admet-1034	30	6	parameterized	parameterize	VERB
admet-1034	30	7	the	the	DET
admet-1034	30	8	excess	excess	NOUN
admet-1034	30	9	of	of	ADP
admet-1034	30	10	the	the	DET
admet-1034	30	11	polar	polar	ADJ
admet-1034	30	12	/	/	SYM
admet-1034	30	13	electrostatic	electrostatic	ADJ
admet-1034	30	14	interactions	interaction	NOUN
admet-1034	30	15	occurring	occur	VERB
admet-1034	30	16	between	between	ADP
admet-1034	30	17	drugs	drug	NOUN
admet-1034	30	18	and	and	CCONJ
admet-1034	30	19	biological	biological	ADJ
admet-1034	30	20	membranes	membrane	NOUN
admet-1034	30	21	as	as	ADP
admet-1034	30	22	δlog	δlog	PROPN
admet-1034	30	23	kw	kw	PROPN
admet-1034	30	24	iam	iam	PROPN
admet-1034	31	1	[	[	X
admet-1034	31	2	14	14	NUM
admet-1034	31	3	-	-	SYM
admet-1034	31	4	19	19	NUM
admet-1034	31	5	]	]	PUNCT
admet-1034	31	6	.	.	PUNCT
admet-1034	32	1	δlog	δlog	PROPN
admet-1034	32	2	kw	kw	PROPN
admet-1034	32	3	iam	iam	PROPN
admet-1034	32	4	is	be	AUX
admet-1034	32	5	obtained	obtain	VERB
admet-1034	32	6	by	by	ADP
admet-1034	32	7	combining	combine	VERB
admet-1034	32	8	n	n	CCONJ
admet-1034	32	9	-	-	PUNCT
admet-1034	32	10	octanol	octanol	NOUN
admet-1034	32	11	/	/	SYM
admet-1034	32	12	water	water	NOUN
admet-1034	32	13	lipophilicity	lipophilicity	NOUN
admet-1034	32	14	with	with	ADP
admet-1034	32	15	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	32	16	,	,	PUNCT
admet-1034	32	17	i.e.	i.e.	X
admet-1034	32	18	,	,	PUNCT
admet-1034	32	19	the	the	DET
admet-1034	32	20	affinity	affinity	NOUN
admet-1034	32	21	of	of	ADP
admet-1034	32	22	the	the	DET
admet-1034	32	23	compound	compound	NOUN
admet-1034	32	24	for	for	ADP
admet-1034	32	25	the	the	DET
admet-1034	32	26	iam	iam	PROPN
admet-1034	32	27	phases	phase	NOUN
admet-1034	32	28	measured	measure	VERB
admet-1034	32	29	as	as	ADP
admet-1034	32	30	a	a	DET
admet-1034	32	31	retention	retention	NOUN
admet-1034	32	32	factor	factor	NOUN
admet-1034	32	33	extrapolated	extrapolate	VERB
admet-1034	32	34	at	at	ADP
admet-1034	32	35	100	100	NUM
admet-1034	32	36	%	%	NOUN
admet-1034	32	37	of	of	ADP
admet-1034	32	38	aqueous	aqueous	ADJ
admet-1034	32	39	phase	phase	NOUN
admet-1034	32	40	(	(	PUNCT
admet-1034	32	41	kw	kw	PROPN
admet-1034	32	42	iam	iam	PROPN
admet-1034	32	43	)	)	PUNCT
admet-1034	33	1	[	[	X
admet-1034	33	2	20	20	NUM
admet-1034	33	3	]	]	PUNCT
admet-1034	33	4	.	.	PUNCT
admet-1034	34	1	this	this	PRON
admet-1034	34	2	represents	represent	VERB
admet-1034	34	3	the	the	DET
admet-1034	34	4	difference	difference	NOUN
admet-1034	34	5	between	between	ADP
admet-1034	34	6	the	the	DET
admet-1034	34	7	logarithm	logarithm	NOUN
admet-1034	34	8	of	of	ADP
admet-1034	34	9	the	the	DET
admet-1034	34	10	chromatographic	chromatographic	ADJ
admet-1034	34	11	retention	retention	NOUN
admet-1034	34	12	factor	factor	NOUN
admet-1034	34	13	(	(	PUNCT
admet-1034	34	14	log	log	PROPN
admet-1034	34	15	kw	kw	PROPN
admet-1034	34	16	iam	iam	PROPN
admet-1034	34	17	)	)	PUNCT
admet-1034	34	18	measured	measure	VERB
admet-1034	34	19	for	for	ADP
admet-1034	34	20	each	each	DET
admet-1034	34	21	analyte	analyte	NOUN
admet-1034	34	22	,	,	PUNCT
admet-1034	34	23	i.e.	i.e.	X
admet-1034	34	24	,	,	PUNCT
admet-1034	34	25	the	the	DET
admet-1034	34	26	experimentally	experimentally	ADV
admet-1034	34	27	determined	determine	VERB
admet-1034	34	28	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	34	29	,	,	PUNCT
admet-1034	34	30	and	and	CCONJ
admet-1034	34	31	the	the	DET
admet-1034	34	32	value	value	NOUN
admet-1034	34	33	expected	expect	VERB
admet-1034	34	34	for	for	ADP
admet-1034	34	35	a	a	DET
admet-1034	34	36	neutral	neutral	ADJ
admet-1034	34	37	isolipophilic	isolipophilic	ADJ
admet-1034	34	38	molecule	molecule	NOUN
admet-1034	34	39	that	that	PRON
admet-1034	34	40	is	be	AUX
admet-1034	34	41	estimated	estimate	VERB
admet-1034	34	42	by	by	ADP
admet-1034	34	43	correlative	correlative	ADJ
admet-1034	34	44	equations	equation	NOUN
admet-1034	34	45	.	.	PUNCT
admet-1034	35	1	δlog	δlog	PROPN
admet-1034	35	2	kw	kw	PROPN
admet-1034	35	3	iam	iam	PROPN
admet-1034	35	4	values	value	NOUN
admet-1034	35	5	were	be	AUX
admet-1034	35	6	inversely	inversely	ADV
admet-1034	35	7	related	relate	VERB
admet-1034	35	8	to	to	ADP
admet-1034	35	9	the	the	DET
admet-1034	35	10	drug	drug	NOUN
admet-1034	35	11	passage	passage	NOUN
admet-1034	35	12	of	of	ADP
admet-1034	35	13	complex	complex	ADJ
admet-1034	35	14	biological	biological	ADJ
admet-1034	35	15	barriers	barrier	NOUN
admet-1034	35	16	,	,	PUNCT
admet-1034	35	17	such	such	ADJ
admet-1034	35	18	as	as	ADP
admet-1034	35	19	the	the	DET
admet-1034	35	20	bbb	bbb	NOUN
admet-1034	35	21	and	and	CCONJ
admet-1034	35	22	the	the	DET
admet-1034	35	23	intestinal	intestinal	ADJ
admet-1034	35	24	wall	wall	NOUN
admet-1034	36	1	[	[	X
admet-1034	36	2	13,17,18	13,17,18	NUM
admet-1034	36	3	]	]	PUNCT
admet-1034	36	4	.	.	PUNCT
admet-1034	37	1	the	the	DET
admet-1034	37	2	increasing	increase	VERB
admet-1034	37	3	need	need	NOUN
admet-1034	37	4	for	for	ADP
admet-1034	37	5	high	high	ADJ
admet-1034	37	6	-	-	PUNCT
admet-1034	37	7	throughput	throughput	NOUN
admet-1034	37	8	drug	drug	NOUN
admet-1034	37	9	discovery	discovery	NOUN
admet-1034	37	10	methods	method	NOUN
admet-1034	37	11	has	have	AUX
admet-1034	37	12	provided	provide	VERB
admet-1034	37	13	several	several	ADJ
admet-1034	37	14	in	in	ADP
admet-1034	37	15	silico	silico	NOUN
admet-1034	37	16	models	model	NOUN
admet-1034	37	17	of	of	ADP
admet-1034	37	18	bbb	bbb	PROPN
admet-1034	37	19	permeation	permeation	NOUN
admet-1034	37	20	based	base	VERB
admet-1034	37	21	on	on	ADP
admet-1034	37	22	in	in	ADP
admet-1034	37	23	vivo	vivo	ADJ
admet-1034	37	24	log	log	NOUN
admet-1034	37	25	bb	bb	NUM
admet-1034	37	26	values	value	NOUN
admet-1034	37	27	[	[	X
admet-1034	37	28	21,22	21,22	X
admet-1034	37	29	]	]	X
admet-1034	37	30	.	.	PUNCT
admet-1034	38	1	log	log	NOUN
admet-1034	38	2	bb	bb	PROPN
admet-1034	38	3	is	be	AUX
admet-1034	38	4	generally	generally	ADV
admet-1034	38	5	measured	measure	VERB
admet-1034	38	6	on	on	ADP
admet-1034	38	7	murine	murine	ADJ
admet-1034	38	8	models	model	NOUN
admet-1034	38	9	and	and	CCONJ
admet-1034	38	10	is	be	AUX
admet-1034	38	11	still	still	ADV
admet-1034	38	12	nowadays	nowadays	ADV
admet-1034	38	13	considered	consider	VERB
admet-1034	38	14	as	as	ADP
admet-1034	38	15	a	a	DET
admet-1034	38	16	solid	solid	ADJ
admet-1034	38	17	indication	indication	NOUN
admet-1034	38	18	for	for	ADP
admet-1034	38	19	bbb	bbb	PROPN
admet-1034	38	20	delivery	delivery	NOUN
admet-1034	39	1	[	[	X
admet-1034	39	2	23	23	NUM
admet-1034	39	3	]	]	PUNCT
admet-1034	39	4	.	.	PUNCT
admet-1034	40	1	log	log	NOUN
admet-1034	40	2	bb	bb	PROPN
admet-1034	40	3	is	be	AUX
admet-1034	40	4	defined	define	VERB
admet-1034	40	5	as	as	ADP
admet-1034	40	6	(	(	PUNCT
admet-1034	40	7	eq	eq	NOUN
admet-1034	40	8	.	.	NOUN
admet-1034	40	9	1	1	NUM
admet-1034	40	10	):	):	PUNCT
admet-1034	40	11	log	log	NOUN
admet-1034	40	12	bb	bb	NOUN
admet-1034	40	13	=	=	NOUN
admet-1034	40	14	log	log	NOUN
admet-1034	40	15	𝐶brain	𝐶brain	PROPN
admet-1034	40	16	𝐶blood	𝐶blood	PROPN
admet-1034	40	17	(	(	PUNCT
admet-1034	40	18	1	1	NUM
admet-1034	40	19	)	)	PUNCT
admet-1034	40	20	in	in	ADP
admet-1034	40	21	which	which	DET
admet-1034	40	22	cbrain	cbrain	NOUN
admet-1034	40	23	is	be	AUX
admet-1034	40	24	the	the	DET
admet-1034	40	25	concentration	concentration	NOUN
admet-1034	40	26	that	that	PRON
admet-1034	40	27	the	the	DET
admet-1034	40	28	analyte	analyte	NOUN
admet-1034	40	29	realizes	realize	VERB
admet-1034	40	30	in	in	ADP
admet-1034	40	31	the	the	DET
admet-1034	40	32	brain	brain	NOUN
admet-1034	40	33	tissues	tissue	NOUN
admet-1034	40	34	,	,	PUNCT
admet-1034	40	35	and	and	CCONJ
admet-1034	40	36	cblood	cblood	NOUN
admet-1034	40	37	is	be	AUX
admet-1034	40	38	the	the	DET
admet-1034	40	39	concentration	concentration	NOUN
admet-1034	40	40	that	that	PRON
admet-1034	40	41	it	it	PRON
admet-1034	40	42	achieves	achieve	VERB
admet-1034	40	43	in	in	ADP
admet-1034	40	44	the	the	DET
admet-1034	40	45	blood	blood	NOUN
admet-1034	40	46	.	.	PUNCT
admet-1034	41	1	the	the	PRON
admet-1034	41	2	in	in	ADP
admet-1034	41	3	silico	silico	NOUN
admet-1034	41	4	models	model	NOUN
admet-1034	41	5	bring	bring	VERB
admet-1034	41	6	the	the	DET
admet-1034	41	7	advantages	advantage	NOUN
admet-1034	41	8	of	of	ADP
admet-1034	41	9	being	be	AUX
admet-1034	41	10	much	much	ADV
admet-1034	41	11	faster	fast	ADJ
admet-1034	41	12	to	to	PART
admet-1034	41	13	perform	perform	VERB
admet-1034	41	14	and	and	CCONJ
admet-1034	41	15	applicable	applicable	ADJ
admet-1034	41	16	to	to	ADP
admet-1034	41	17	molecules	molecule	NOUN
admet-1034	41	18	that	that	PRON
admet-1034	41	19	are	be	AUX
admet-1034	41	20	not	not	PART
admet-1034	41	21	yet	yet	ADV
admet-1034	41	22	synthesized	synthesize	VERB
admet-1034	41	23	and/or	and/or	CCONJ
admet-1034	41	24	not	not	PART
admet-1034	41	25	easily	easily	ADV
admet-1034	41	26	detectable	detectable	ADJ
admet-1034	41	27	.	.	PUNCT
admet-1034	42	1	back	back	ADV
admet-1034	42	2	in	in	ADP
admet-1034	42	3	2017	2017	NUM
admet-1034	42	4	,	,	PUNCT
admet-1034	42	5	we	we	PRON
admet-1034	42	6	developed	develop	VERB
admet-1034	42	7	some	some	DET
admet-1034	42	8	statistical	statistical	ADJ
admet-1034	42	9	models	model	NOUN
admet-1034	42	10	to	to	PART
admet-1034	42	11	predict	predict	VERB
admet-1034	42	12	the	the	DET
admet-1034	42	13	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	42	14	of	of	ADP
admet-1034	42	15	small	small	ADJ
admet-1034	42	16	molecules	molecule	NOUN
admet-1034	42	17	based	base	VERB
admet-1034	42	18	on	on	ADP
admet-1034	42	19	more	more	ADJ
admet-1034	42	20	than	than	ADP
admet-1034	42	21	200	200	NUM
admet-1034	42	22	individual	individual	ADJ
admet-1034	42	23	measurements	measurement	NOUN
admet-1034	42	24	performed	perform	VERB
admet-1034	42	25	in	in	ADP
admet-1034	42	26	our	our	PRON
admet-1034	42	27	laboratories	laboratory	NOUN
admet-1034	42	28	.	.	PUNCT
admet-1034	43	1	this	this	PRON
admet-1034	43	2	also	also	ADV
admet-1034	43	3	materialized	materialize	VERB
admet-1034	43	4	in	in	ADP
admet-1034	43	5	an	an	DET
admet-1034	43	6	online	online	ADJ
admet-1034	43	7	service	service	NOUN
admet-1034	43	8	,	,	PUNCT
admet-1034	43	9	namely	namely	ADV
admet-1034	43	10	log	log	VERB
admet-1034	43	11	kw	kw	NOUN
admet-1034	43	12	iam.mg/dd2	iam.mg/dd2	PROPN
admet-1034	43	13	calculator	calculator	NOUN
admet-1034	43	14	,	,	PUNCT
admet-1034	43	15	offering	offer	VERB
admet-1034	43	16	the	the	DET
admet-1034	43	17	opportunity	opportunity	NOUN
admet-1034	43	18	to	to	PART
admet-1034	43	19	predict	predict	VERB
admet-1034	43	20	the	the	DET
admet-1034	43	21	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	43	22	of	of	ADP
admet-1034	43	23	all	all	DET
admet-1034	43	24	compounds	compound	NOUN
admet-1034	43	25	included	include	VERB
admet-1034	43	26	in	in	ADP
admet-1034	43	27	pubchem	pubchem	NOUN
admet-1034	43	28	collection	collection	NOUN
admet-1034	43	29	as	as	ADP
admet-1034	43	30	log	log	PROPN
admet-1034	43	31	kw	kw	PROPN
admet-1034	43	32	iam	iam	PROPN
admet-1034	43	33	on	on	ADP
admet-1034	43	34	both	both	DET
admet-1034	43	35	mg	mg	PROPN
admet-1034	43	36	and	and	CCONJ
admet-1034	43	37	dd2	dd2	PROPN
admet-1034	43	38	chromatographic	chromatographic	ADJ
admet-1034	43	39	columns	column	NOUN
admet-1034	43	40	[	[	X
admet-1034	43	41	24	24	NUM
admet-1034	43	42	]	]	PUNCT
admet-1034	43	43	.	.	PUNCT
admet-1034	44	1	in	in	ADP
admet-1034	44	2	the	the	DET
admet-1034	44	3	present	present	ADJ
admet-1034	44	4	study	study	NOUN
admet-1034	44	5	,	,	PUNCT
admet-1034	44	6	we	we	PRON
admet-1034	44	7	aim	aim	VERB
admet-1034	44	8	at	at	ADP
admet-1034	44	9	applying	apply	VERB
admet-1034	44	10	these	these	DET
admet-1034	44	11	statistical	statistical	ADJ
admet-1034	44	12	models	model	NOUN
admet-1034	44	13	to	to	PART
admet-1034	44	14	calculate	calculate	VERB
admet-1034	44	15	the	the	DET
admet-1034	44	16	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	44	17	of	of	ADP
admet-1034	44	18	a	a	DET
admet-1034	44	19	dataset	dataset	NOUN
admet-1034	44	20	of	of	ADP
admet-1034	44	21	compounds	compound	NOUN
admet-1034	44	22	whose	whose	DET
admet-1034	44	23	log	log	NOUN
admet-1034	44	24	bb	bb	NOUN
admet-1034	44	25	is	be	AUX
admet-1034	44	26	known	know	VERB
admet-1034	44	27	from	from	ADP
admet-1034	44	28	the	the	DET
admet-1034	44	29	scientific	scientific	ADJ
admet-1034	44	30	literature	literature	NOUN
admet-1034	44	31	and	and	CCONJ
admet-1034	44	32	from	from	ADP
admet-1034	44	33	there	there	ADV
admet-1034	44	34	to	to	PART
admet-1034	44	35	estimate	estimate	VERB
admet-1034	44	36	δlog	δlog	PROPN
admet-1034	44	37	kw	kw	PROPN
admet-1034	44	38	iam	iam	PROPN
admet-1034	44	39	,	,	PUNCT
admet-1034	44	40	based	base	VERB
admet-1034	44	41	either	either	CCONJ
admet-1034	44	42	on	on	ADP
admet-1034	44	43	experimentally	experimentally	ADV
admet-1034	44	44	determined	determine	VERB
admet-1034	44	45	or	or	CCONJ
admet-1034	44	46	calculated	calculate	VERB
admet-1034	44	47	lipophilicity	lipophilicity	NOUN
admet-1034	44	48	values	value	NOUN
admet-1034	44	49	.	.	PUNCT
admet-1034	45	1	our	our	PRON
admet-1034	45	2	goal	goal	NOUN
admet-1034	45	3	is	be	AUX
admet-1034	45	4	to	to	PART
admet-1034	45	5	evaluate	evaluate	VERB
admet-1034	45	6	whether	whether	SCONJ
admet-1034	45	7	these	these	DET
admet-1034	45	8	parameters	parameter	NOUN
admet-1034	45	9	calculated	calculate	VERB
admet-1034	45	10	in	in	ADP
admet-1034	45	11	silico	silico	NOUN
admet-1034	45	12	,	,	PUNCT
admet-1034	45	13	therefore	therefore	ADV
admet-1034	45	14	called	call	VERB
admet-1034	45	15	from	from	ADP
admet-1034	45	16	here	here	ADV
admet-1034	45	17	on	on	ADP
admet-1034	45	18	cδlog	cδlog	PROPN
admet-1034	45	19	kw	kw	PROPN
admet-1034	45	20	iam	iam	PROPN
admet-1034	45	21	,	,	PUNCT
admet-1034	45	22	can	can	AUX
admet-1034	45	23	offer	offer	VERB
admet-1034	45	24	effectiveness	effectiveness	NOUN
admet-1034	45	25	in	in	ADP
admet-1034	45	26	screening	screen	VERB
admet-1034	45	27	libraries	library	NOUN
admet-1034	45	28	of	of	ADP
admet-1034	45	29	compounds	compound	NOUN
admet-1034	45	30	for	for	ADP
admet-1034	45	31	their	their	PRON
admet-1034	45	32	potential	potential	NOUN
admet-1034	45	33	to	to	PART
admet-1034	45	34	reach	reach	VERB
admet-1034	45	35	the	the	DET
admet-1034	45	36	brain	brain	NOUN
admet-1034	45	37	.	.	PUNCT
admet-1034	46	1	if	if	SCONJ
admet-1034	46	2	so	so	ADV
admet-1034	46	3	,	,	PUNCT
admet-1034	46	4	we	we	PRON
admet-1034	46	5	will	will	AUX
admet-1034	46	6	look	look	VERB
admet-1034	46	7	at	at	ADP
admet-1034	46	8	ways	way	NOUN
admet-1034	46	9	to	to	PART
admet-1034	46	10	implement	implement	VERB
admet-1034	46	11	these	these	DET
admet-1034	46	12	procedures	procedure	NOUN
admet-1034	46	13	in	in	ADP
admet-1034	46	14	the	the	DET
admet-1034	46	15	drug	drug	NOUN
admet-1034	46	16	discovery	discovery	NOUN
admet-1034	46	17	/	/	SYM
admet-1034	46	18	development	development	NOUN
admet-1034	46	19	industrial	industrial	ADJ
admet-1034	46	20	programs	program	NOUN
admet-1034	46	21	.	.	PUNCT
admet-1034	47	1	admet	admet	PROPN
admet-1034	47	2	&	&	CCONJ
admet-1034	47	3	dmpk	dmpk	PROPN
admet-1034	47	4	9(4	9(4	PROPN
admet-1034	47	5	)	)	PUNCT
admet-1034	47	6	(	(	PUNCT
admet-1034	47	7	2021	2021	NUM
admet-1034	47	8	)	)	PUNCT
admet-1034	47	9	267	267	NUM
admet-1034	47	10	-	-	SYM
admet-1034	47	11	281	281	NUM
admet-1034	47	12	bbb	bbb	PROPN
admet-1034	47	13	passage	passage	NOUN
admet-1034	47	14	based	base	VERB
admet-1034	47	15	on	on	ADP
admet-1034	47	16	in	in	ADP
admet-1034	47	17	silico	silico	NOUN
admet-1034	47	18	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	47	19	doi	doi	NOUN
admet-1034	47	20	:	:	PUNCT
admet-1034	47	21	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	47	22	269	269	NUM
admet-1034	47	23	experimental	experimental	ADJ
admet-1034	47	24	data	datum	NOUN
admet-1034	47	25	collection	collection	NOUN
admet-1034	47	26	experimental	experimental	ADJ
admet-1034	47	27	lipophilicity	lipophilicity	NOUN
admet-1034	47	28	values	value	NOUN
admet-1034	47	29	were	be	AUX
admet-1034	47	30	collected	collect	VERB
admet-1034	47	31	from	from	ADP
admet-1034	47	32	the	the	DET
admet-1034	47	33	scientific	scientific	ADJ
admet-1034	47	34	literature	literature	NOUN
admet-1034	47	35	.	.	PUNCT
admet-1034	48	1	specifically	specifically	ADV
admet-1034	48	2	,	,	PUNCT
admet-1034	48	3	all	all	DET
admet-1034	48	4	the	the	DET
admet-1034	48	5	log	log	NOUN
admet-1034	48	6	p	p	NOUN
admet-1034	48	7	values	value	NOUN
admet-1034	48	8	were	be	AUX
admet-1034	48	9	taken	take	VERB
admet-1034	48	10	from	from	ADP
admet-1034	48	11	pubchem	pubchem	NOUN
admet-1034	48	12	but	but	CCONJ
admet-1034	48	13	those	those	PRON
admet-1034	48	14	of	of	ADP
admet-1034	48	15	nevirapine	nevirapine	ADJ
admet-1034	48	16	and	and	CCONJ
admet-1034	48	17	thioxolone	thioxolone	NOUN
admet-1034	48	18	,	,	PUNCT
admet-1034	48	19	which	which	PRON
admet-1034	48	20	were	be	AUX
admet-1034	48	21	taken	take	VERB
admet-1034	48	22	from	from	ADP
admet-1034	48	23	the	the	DET
admet-1034	48	24	literature	literature	NOUN
admet-1034	48	25	[	[	X
admet-1034	48	26	25	25	NUM
admet-1034	48	27	]	]	PUNCT
admet-1034	48	28	.	.	PUNCT
admet-1034	49	1	calculated	calculate	VERB
admet-1034	49	2	log	log	NOUN
admet-1034	49	3	p	p	NOUN
admet-1034	49	4	values	value	NOUN
admet-1034	49	5	were	be	AUX
admet-1034	49	6	obtained	obtain	VERB
admet-1034	49	7	by	by	ADP
admet-1034	49	8	either	either	DET
admet-1034	49	9	alogps	alogps	PROPN
admet-1034	50	1	[	[	X
admet-1034	50	2	26	26	NUM
admet-1034	50	3	]	]	PUNCT
admet-1034	50	4	or	or	CCONJ
admet-1034	50	5	by	by	ADP
admet-1034	50	6	marvinsketch	marvinsketch	NOUN
admet-1034	50	7	[	[	X
admet-1034	50	8	27	27	NUM
admet-1034	50	9	]	]	PUNCT
admet-1034	50	10	.	.	PUNCT
admet-1034	51	1	for	for	ADP
admet-1034	51	2	acidic	acidic	ADJ
admet-1034	51	3	compounds	compound	NOUN
admet-1034	51	4	,	,	PUNCT
admet-1034	51	5	whose	whose	DET
admet-1034	51	6	’log	’log	INTJ
admet-1034	51	7	kw	kw	INTJ
admet-1034	51	8	iam	iam	PROPN
admet-1034	51	9	but	but	CCONJ
admet-1034	51	10	not	not	PART
admet-1034	51	11	their	their	PRON
admet-1034	51	12	log	log	PROPN
admet-1034	51	13	kw	kw	PROPN
admet-1034	51	14	iam	iam	PROPN
admet-1034	51	15	were	be	AUX
admet-1034	51	16	previously	previously	ADV
admet-1034	51	17	found	find	VERB
admet-1034	51	18	related	relate	VERB
admet-1034	51	19	to	to	PART
admet-1034	51	20	log	log	VERB
admet-1034	51	21	bb	bb	NUM
admet-1034	51	22	,	,	PUNCT
admet-1034	51	23	log	log	NOUN
admet-1034	51	24	d7.4	d7.4	NOUN
admet-1034	51	25	values	value	NOUN
admet-1034	51	26	were	be	AUX
admet-1034	51	27	again	again	ADV
admet-1034	51	28	calculated	calculate	VERB
admet-1034	51	29	by	by	ADP
admet-1034	51	30	marvinsketch	marvinsketch	NOUN
admet-1034	51	31	software	software	NOUN
admet-1034	51	32	[	[	X
admet-1034	51	33	27	27	NUM
admet-1034	51	34	]	]	PUNCT
admet-1034	51	35	.	.	PUNCT
admet-1034	52	1	log	log	NOUN
admet-1034	52	2	bb	bb	NUM
admet-1034	52	3	values	value	NOUN
admet-1034	52	4	were	be	AUX
admet-1034	52	5	taken	take	VERB
admet-1034	52	6	from	from	ADP
admet-1034	52	7	the	the	DET
admet-1034	52	8	literature	literature	NOUN
admet-1034	52	9	[	[	X
admet-1034	52	10	28	28	NUM
admet-1034	52	11	]	]	PUNCT
admet-1034	52	12	.	.	PUNCT
admet-1034	53	1	c/’log	c/’log	PROPN
admet-1034	53	2	kw	kw	PROPN
admet-1034	53	3	iam	iam	PROPN
admet-1034	53	4	values	value	VERB
admet-1034	53	5	calculation	calculation	NOUN
admet-1034	53	6	c/’log	c/’log	PROPN
admet-1034	53	7	kw	kw	PROPN
admet-1034	53	8	iam	iam	PROPN
admet-1034	53	9	values	value	NOUN
admet-1034	53	10	were	be	AUX
admet-1034	53	11	calculated	calculate	VERB
admet-1034	53	12	from	from	ADP
admet-1034	53	13	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	53	14	values	value	NOUN
admet-1034	53	15	estimated	estimate	VERB
admet-1034	53	16	in	in	ADP
admet-1034	53	17	silico	silico	NOUN
admet-1034	53	18	according	accord	VERB
admet-1034	53	19	to	to	ADP
admet-1034	53	20	a	a	DET
admet-1034	53	21	procedure	procedure	NOUN
admet-1034	53	22	we	we	PRON
admet-1034	53	23	developed	develop	VERB
admet-1034	53	24	in	in	ADP
admet-1034	53	25	2017	2017	NUM
admet-1034	53	26	[	[	X
admet-1034	53	27	24	24	NUM
admet-1034	53	28	]	]	PUNCT
admet-1034	53	29	.	.	PUNCT
admet-1034	54	1	in	in	ADP
admet-1034	54	2	brief	brief	NOUN
admet-1034	54	3	,	,	PUNCT
admet-1034	54	4	the	the	DET
admet-1034	54	5	best	good	ADJ
admet-1034	54	6	relationships	relationship	NOUN
admet-1034	54	7	were	be	AUX
admet-1034	54	8	found	find	VERB
admet-1034	54	9	to	to	PART
admet-1034	54	10	be	be	AUX
admet-1034	54	11	:	:	PUNCT
admet-1034	54	12	log	log	VERB
admet-1034	54	13	kw	kw	INTJ
admet-1034	54	14	iam.mg	iam.mg	PROPN
admet-1034	55	1	=	=	PUNCT
admet-1034	55	2	-0.1405	-0.1405	X
admet-1034	55	3	(	(	PUNCT
admet-1034	55	4	0.1282	0.1282	ADJ
admet-1034	55	5	)	)	PUNCT
admet-1034	55	6	+	+	NUM
admet-1034	55	7	0.4401(0.0297)milogp	0.4401(0.0297)milogp	NOUN
admet-1034	56	1	+	+	CCONJ
admet-1034	56	2	0.0536	0.0536	NUM
admet-1034	56	3	(	(	PUNCT
admet-1034	56	4	0.0057)heavy	0.0057)heavy	NOUN
admet-1034	56	5	atoms	atom	NOUN
admet-1034	56	6	0.0833	0.0833	NUM
admet-1034	56	7	(	(	PUNCT
admet-1034	56	8	0.0201)hlbm	0.0201)hlbm	NOUN
admet-1034	56	9	0.0435(0.0144)rotatable	0.0435(0.0144)rotatable	ADJ
admet-1034	56	10	bonds	bond	NOUN
admet-1034	56	11	(	(	PUNCT
admet-1034	56	12	2	2	X
admet-1034	56	13	)	)	PUNCT
admet-1034	56	14	n=204	n=204	NOUN
admet-1034	56	15	r2	r2	NOUN
admet-1034	56	16	=	=	SYM
admet-1034	56	17	0.81	0.81	NUM
admet-1034	56	18	q2	q2	NOUN
admet-1034	56	19	=	=	SYM
admet-1034	56	20	0.80	0.80	NUM
admet-1034	56	21	se	se	X
admet-1034	56	22	=	=	NOUN
admet-1034	56	23	0.438	0.438	NUM
admet-1034	56	24	f4,199	f4,199	NOUN
admet-1034	56	25	=	=	SYM
admet-1034	56	26	213.92	213.92	NUM
admet-1034	56	27	p<1.0	p<1.0	NOUN
admet-1034	56	28	10	10	NUM
admet-1034	56	29	-	-	SYM
admet-1034	56	30	8	8	NUM
admet-1034	56	31	pc	pc	NOUN
admet-1034	56	32	=	=	SYM
admet-1034	56	33	39.403	39.403	NUM
admet-1034	56	34	and	and	CCONJ
admet-1034	56	35	log	log	VERB
admet-1034	56	36	kw	kw	INTJ
admet-1034	56	37	iam.dd2	iam.dd2	ADV
admet-1034	56	38	=	=	NUM
admet-1034	56	39	-2.3989	-2.3989	ADJ
admet-1034	56	40	(	(	PUNCT
admet-1034	56	41	0.2812	0.2812	NOUN
admet-1034	56	42	)	)	PUNCT
admet-1034	56	43	+	+	NUM
admet-1034	56	44	0.4936(0.0379)milogp	0.4936(0.0379)milogp	NOUN
admet-1034	56	45	+	+	CCONJ
admet-1034	56	46	0.4354	0.4354	NUM
admet-1034	56	47	(	(	PUNCT
admet-1034	56	48	0.0470)volume	0.0470)volume	X
admet-1034	56	49	diameter	diameter	NOUN
admet-1034	56	50	0.0640	0.0640	NUM
admet-1034	56	51	(	(	PUNCT
admet-1034	56	52	0.0226)hlbpsa	0.0226)hlbpsa	NOUN
admet-1034	56	53	0.0497(0.0173)rotatable	0.0497(0.0173)rotatable	ADJ
admet-1034	56	54	bonds	bond	NOUN
admet-1034	56	55	(	(	PUNCT
admet-1034	56	56	3	3	X
admet-1034	56	57	)	)	PUNCT
admet-1034	56	58	n=160	n=160	PROPN
admet-1034	56	59	r2	r2	NOUN
admet-1034	56	60	=	=	SYM
admet-1034	56	61	0.85	0.85	NUM
admet-1034	56	62	q2	q2	NOUN
admet-1034	56	63	=	=	SYM
admet-1034	56	64	0.84	0.84	NUM
admet-1034	56	65	se	se	X
admet-1034	57	1	=	=	NOUN
admet-1034	57	2	0.459	0.459	NUM
admet-1034	57	3	f4,155	f4,155	PROPN
admet-1034	57	4	=	=	SYM
admet-1034	57	5	212.94	212.94	NUM
admet-1034	57	6	p<1.0	p<1.0	NOUN
admet-1034	57	7	10	10	NUM
admet-1034	57	8	-	-	SYM
admet-1034	57	9	8	8	NUM
admet-1034	57	10	pc	pc	NOUN
admet-1034	57	11	=	=	NOUN
admet-1034	57	12	33.974	33.974	NUM
admet-1034	57	13	a	a	DET
admet-1034	57	14	detailed	detailed	ADJ
admet-1034	57	15	explanation	explanation	NOUN
admet-1034	57	16	of	of	ADP
admet-1034	57	17	the	the	DET
admet-1034	57	18	main	main	ADJ
admet-1034	57	19	descriptors	descriptor	NOUN
admet-1034	57	20	,	,	PUNCT
admet-1034	57	21	along	along	ADP
admet-1034	57	22	with	with	ADP
admet-1034	57	23	relevant	relevant	ADJ
admet-1034	57	24	references	reference	NOUN
admet-1034	57	25	,	,	PUNCT
admet-1034	57	26	is	be	AUX
admet-1034	57	27	reported	report	VERB
admet-1034	57	28	in	in	ADP
admet-1034	57	29	supporting	support	VERB
admet-1034	57	30	information	information	NOUN
admet-1034	57	31	(	(	PUNCT
admet-1034	57	32	table	table	NOUN
admet-1034	57	33	s1	s1	NOUN
admet-1034	57	34	)	)	PUNCT
admet-1034	57	35	.	.	PUNCT
admet-1034	58	1	in	in	ADP
admet-1034	58	2	these	these	DET
admet-1034	58	3	equations	equation	NOUN
admet-1034	58	4	,	,	PUNCT
admet-1034	58	5	n	n	X
admet-1034	58	6	is	be	AUX
admet-1034	58	7	the	the	DET
admet-1034	58	8	number	number	NOUN
admet-1034	58	9	of	of	ADP
admet-1034	58	10	data	datum	NOUN
admet-1034	58	11	considered	consider	VERB
admet-1034	58	12	to	to	PART
admet-1034	58	13	derive	derive	VERB
admet-1034	58	14	the	the	DET
admet-1034	58	15	regression	regression	NOUN
admet-1034	58	16	equation	equation	NOUN
admet-1034	58	17	,	,	PUNCT
admet-1034	58	18	r2	r2	PROPN
admet-1034	58	19	is	be	AUX
admet-1034	58	20	the	the	DET
admet-1034	58	21	square	square	NOUN
admet-1034	58	22	of	of	ADP
admet-1034	58	23	the	the	DET
admet-1034	58	24	correlation	correlation	NOUN
admet-1034	58	25	coefficient	coefficient	NOUN
admet-1034	58	26	,	,	PUNCT
admet-1034	58	27	se	se	X
admet-1034	58	28	is	be	AUX
admet-1034	58	29	the	the	DET
admet-1034	58	30	standard	standard	ADJ
admet-1034	58	31	error	error	NOUN
admet-1034	58	32	of	of	ADP
admet-1034	58	33	the	the	DET
admet-1034	58	34	estimate	estimate	NOUN
admet-1034	58	35	,	,	PUNCT
admet-1034	58	36	f	f	PROPN
admet-1034	58	37	(	(	PUNCT
admet-1034	58	38	the	the	DET
admet-1034	58	39	subscripts	subscript	NOUN
admet-1034	58	40	are	be	AUX
admet-1034	58	41	the	the	DET
admet-1034	58	42	degrees	degree	NOUN
admet-1034	58	43	of	of	ADP
admet-1034	58	44	freedom	freedom	NOUN
admet-1034	58	45	and	and	CCONJ
admet-1034	58	46	the	the	DET
admet-1034	58	47	number	number	NOUN
admet-1034	58	48	of	of	ADP
admet-1034	58	49	variables	variable	NOUN
admet-1034	58	50	)	)	PUNCT
admet-1034	58	51	is	be	AUX
admet-1034	58	52	the	the	DET
admet-1034	58	53	fisher	fisher	PROPN
admet-1034	58	54	statistic	statistic	NOUN
admet-1034	58	55	of	of	ADP
admet-1034	58	56	the	the	DET
admet-1034	58	57	regression	regression	NOUN
admet-1034	58	58	,	,	PUNCT
admet-1034	58	59	p	p	NOUN
admet-1034	58	60	is	be	AUX
admet-1034	58	61	the	the	DET
admet-1034	58	62	observed	observe	VERB
admet-1034	58	63	significance	significance	NOUN
admet-1034	58	64	level	level	NOUN
admet-1034	58	65	,	,	PUNCT
admet-1034	58	66	i.e.	i.e.	X
admet-1034	58	67	,	,	PUNCT
admet-1034	58	68	the	the	DET
admet-1034	58	69	probability	probability	NOUN
admet-1034	58	70	of	of	ADP
admet-1034	58	71	obtaining	obtain	VERB
admet-1034	58	72	a	a	DET
admet-1034	58	73	result	result	NOUN
admet-1034	58	74	equal	equal	ADJ
admet-1034	58	75	to	to	ADP
admet-1034	58	76	or	or	CCONJ
admet-1034	58	77	“	"	PUNCT
admet-1034	58	78	more	more	ADV
admet-1034	58	79	extreme	extreme	ADJ
admet-1034	58	80	”	"	PUNCT
admet-1034	58	81	than	than	ADP
admet-1034	58	82	what	what	PRON
admet-1034	58	83	was	be	AUX
admet-1034	58	84	observed	observe	VERB
admet-1034	58	85	,	,	PUNCT
admet-1034	58	86	and	and	CCONJ
admet-1034	58	87	pc	pc	NOUN
admet-1034	58	88	is	be	AUX
admet-1034	58	89	the	the	DET
admet-1034	58	90	amemiya	amemiya	NOUN
admet-1034	58	91	predictive	predictive	ADJ
admet-1034	58	92	criterion	criterion	NOUN
admet-1034	58	93	of	of	ADP
admet-1034	58	94	the	the	DET
admet-1034	58	95	regression	regression	NOUN
admet-1034	58	96	.	.	PUNCT
admet-1034	59	1	the	the	DET
admet-1034	59	2	hydrophilic	hydrophilic	ADJ
admet-1034	59	3	-	-	PUNCT
admet-1034	59	4	lipophilic	lipophilic	ADJ
admet-1034	59	5	balance	balance	NOUN
admet-1034	59	6	(	(	PUNCT
admet-1034	59	7	hlb	hlb	PROPN
admet-1034	59	8	)	)	PUNCT
admet-1034	59	9	can	can	AUX
admet-1034	59	10	be	be	AUX
admet-1034	59	11	taken	take	VERB
admet-1034	59	12	into	into	ADP
admet-1034	59	13	account	account	NOUN
admet-1034	59	14	by	by	ADP
admet-1034	59	15	the	the	DET
admet-1034	59	16	methods	method	NOUN
admet-1034	59	17	by	by	ADP
admet-1034	59	18	griffin	griffin	NOUN
admet-1034	60	1	[	[	X
admet-1034	60	2	29	29	NUM
admet-1034	60	3	]	]	PUNCT
admet-1034	60	4	(	(	PUNCT
admet-1034	60	5	hlbg	hlbg	NOUN
admet-1034	60	6	)	)	PUNCT
admet-1034	60	7	,	,	PUNCT
admet-1034	60	8	davies	davy	NOUN
admet-1034	60	9	[	[	X
admet-1034	60	10	30	30	NUM
admet-1034	60	11	]	]	PUNCT
admet-1034	60	12	(	(	PUNCT
admet-1034	60	13	hlbd	hlbd	NOUN
admet-1034	60	14	)	)	PUNCT
admet-1034	60	15	,	,	PUNCT
admet-1034	60	16	and	and	CCONJ
admet-1034	60	17	taking	take	VERB
admet-1034	60	18	into	into	ADP
admet-1034	60	19	account	account	NOUN
admet-1034	60	20	the	the	DET
admet-1034	60	21	steric	steric	ADJ
admet-1034	60	22	effects	effect	NOUN
admet-1034	60	23	(	(	PUNCT
admet-1034	60	24	hlbpsa	hlbpsa	NOUN
admet-1034	60	25	)	)	PUNCT
admet-1034	60	26	,	,	PUNCT
admet-1034	60	27	not	not	PART
admet-1034	60	28	considered	consider	VERB
admet-1034	60	29	by	by	ADP
admet-1034	60	30	the	the	DET
admet-1034	60	31	two	two	NUM
admet-1034	60	32	approaches	approach	NOUN
admet-1034	60	33	.	.	PUNCT
admet-1034	61	1	hlbpsa	hlbpsa	PROPN
admet-1034	61	2	is	be	AUX
admet-1034	61	3	defined	define	VERB
admet-1034	61	4	as	as	SCONJ
admet-1034	61	5	follows	follow	VERB
admet-1034	61	6	:	:	PUNCT
admet-1034	61	7	hlbpsa=20⋅psa	hlbpsa=20⋅psa	NOUN
admet-1034	61	8	/	/	SYM
admet-1034	61	9	surface	surface	NOUN
admet-1034	61	10	where	where	SCONJ
admet-1034	61	11	psa	psa	NOUN
admet-1034	61	12	is	be	AUX
admet-1034	61	13	the	the	DET
admet-1034	61	14	polar	polar	ADJ
admet-1034	61	15	surface	surface	NOUN
admet-1034	61	16	area	area	NOUN
admet-1034	61	17	and	and	CCONJ
admet-1034	61	18	surface	surface	NOUN
admet-1034	61	19	is	be	AUX
admet-1034	61	20	the	the	DET
admet-1034	61	21	total	total	ADJ
admet-1034	61	22	surface	surface	NOUN
admet-1034	61	23	.	.	PUNCT
admet-1034	62	1	hlb	hlb	PROPN
admet-1034	62	2	(	(	PUNCT
admet-1034	62	3	hlbm	hlbm	PROPN
admet-1034	62	4	)	)	PUNCT
admet-1034	62	5	is	be	AUX
admet-1034	62	6	the	the	DET
admet-1034	62	7	mean	mean	NOUN
admet-1034	62	8	resulting	result	VERB
admet-1034	62	9	from	from	ADP
admet-1034	62	10	the	the	DET
admet-1034	62	11	values	value	NOUN
admet-1034	62	12	by	by	ADP
admet-1034	62	13	all	all	DET
admet-1034	62	14	three	three	NUM
admet-1034	62	15	methods	method	NOUN
admet-1034	62	16	.	.	PUNCT
admet-1034	63	1	milogp	milogp	PROPN
admet-1034	63	2	is	be	AUX
admet-1034	63	3	the	the	DET
admet-1034	63	4	octanol	octanol	NOUN
admet-1034	63	5	-	-	PUNCT
admet-1034	63	6	water	water	NOUN
admet-1034	63	7	partition	partition	NOUN
admet-1034	63	8	coefficient	coefficient	NOUN
admet-1034	63	9	predicted	predict	VERB
admet-1034	63	10	by	by	ADP
admet-1034	63	11	the	the	DET
admet-1034	63	12	online	online	ADJ
admet-1034	63	13	program	program	NOUN
admet-1034	63	14	for	for	ADP
admet-1034	63	15	the	the	DET
admet-1034	63	16	calculation	calculation	NOUN
admet-1034	63	17	of	of	ADP
admet-1034	63	18	molecular	molecular	ADJ
admet-1034	63	19	properties	property	NOUN
admet-1034	63	20	and	and	CCONJ
admet-1034	63	21	bioactivity	bioactivity	NOUN
admet-1034	63	22	prediction	prediction	NOUN
admet-1034	63	23	[	[	X
admet-1034	63	24	31	31	NUM
admet-1034	63	25	]	]	PUNCT
admet-1034	63	26	.	.	PUNCT
admet-1034	64	1	the	the	DET
admet-1034	64	2	calculations	calculation	NOUN
admet-1034	64	3	were	be	AUX
admet-1034	64	4	made	make	VERB
admet-1034	64	5	completely	completely	ADV
admet-1034	64	6	automated	automate	VERB
admet-1034	64	7	and	and	CCONJ
admet-1034	64	8	easily	easily	ADV
admet-1034	64	9	accessible	accessible	ADJ
admet-1034	64	10	to	to	ADP
admet-1034	64	11	anyone	anyone	PRON
admet-1034	64	12	via	via	ADP
admet-1034	64	13	a	a	DET
admet-1034	64	14	user	user	NOUN
admet-1034	64	15	-	-	PUNCT
admet-1034	64	16	friend	friend	NOUN
admet-1034	64	17	tool	tool	NOUN
admet-1034	64	18	to	to	PART
admet-1034	64	19	predict	predict	VERB
admet-1034	64	20	log	log	NOUN
admet-1034	64	21	kw	kw	INTJ
admet-1034	64	22	iam.mg	iam.mg	PROPN
admet-1034	64	23	and	and	CCONJ
admet-1034	64	24	log	log	VERB
admet-1034	64	25	kw	kw	INTJ
admet-1034	64	26	iam.dd2	iam.dd2	PROPN
admet-1034	64	27	,	,	PUNCT
admet-1034	64	28	a	a	DET
admet-1034	64	29	web	web	NOUN
admet-1034	64	30	service	service	NOUN
admet-1034	64	31	and	and	CCONJ
admet-1034	64	32	a	a	DET
admet-1034	64	33	set	set	NOUN
admet-1034	64	34	of	of	ADP
admet-1034	64	35	scripts	script	NOUN
admet-1034	64	36	for	for	ADP
admet-1034	64	37	vega	vega	PROPN
admet-1034	64	38	zz	zz	PROPN
admet-1034	64	39	program	program	PROPN
admet-1034	64	40	[	[	X
admet-1034	64	41	24	24	NUM
admet-1034	64	42	]	]	PUNCT
admet-1034	64	43	.	.	PUNCT
admet-1034	65	1	this	this	PRON
admet-1034	65	2	is	be	AUX
admet-1034	65	3	available	available	ADJ
admet-1034	65	4	at	at	ADP
admet-1034	65	5	https://www.ddl.unimi.it/vegaol/logkwiam.htm	https://www.ddl.unimi.it/vegaol/logkwiam.htm	NOUN
admet-1034	65	6	and	and	CCONJ
admet-1034	65	7	offers	offer	VERB
admet-1034	65	8	a	a	DET
admet-1034	65	9	calculation	calculation	NOUN
admet-1034	65	10	of	of	ADP
admet-1034	65	11	log	log	NOUN
admet-1034	65	12	kiam.mg/dd2	kiam.mg/dd2	NOUN
admet-1034	65	13	of	of	ADP
admet-1034	65	14	any	any	DET
admet-1034	65	15	molecule	molecule	NOUN
admet-1034	65	16	included	include	VERB
admet-1034	65	17	in	in	ADP
admet-1034	65	18	the	the	DET
admet-1034	65	19	pubchem	pubchem	NOUN
admet-1034	65	20	collection	collection	NOUN
admet-1034	65	21	as	as	SCONJ
admet-1034	65	22	implemented	implement	VERB
admet-1034	65	23	in	in	ADP
admet-1034	65	24	the	the	DET
admet-1034	65	25	script	script	NOUN
admet-1034	65	26	version	version	NOUN
admet-1034	65	27	.	.	PUNCT
admet-1034	66	1	log	log	PROPN
admet-1034	66	2	kw	kw	PROPN
admet-1034	66	3	iam	iam	PROPN
admet-1034	66	4	values	value	NOUN
admet-1034	66	5	were	be	AUX
admet-1034	66	6	calculated	calculate	VERB
admet-1034	66	7	as	as	ADP
admet-1034	66	8	the	the	DET
admet-1034	66	9	difference	difference	NOUN
admet-1034	66	10	between	between	ADP
admet-1034	66	11	the	the	DET
admet-1034	66	12	log	log	NOUN
admet-1034	66	13	kw	kw	PROPN
admet-1034	66	14	iam	iam	PROPN
admet-1034	66	15	computed	compute	VERB
admet-1034	66	16	from	from	ADP
admet-1034	66	17	equations	equation	NOUN
admet-1034	66	18	(	(	PUNCT
admet-1034	66	19	2	2	NUM
admet-1034	66	20	)	)	PUNCT
admet-1034	66	21	and	and	CCONJ
admet-1034	66	22	(	(	PUNCT
admet-1034	66	23	3	3	X
admet-1034	66	24	)	)	PUNCT
admet-1034	66	25	and	and	CCONJ
admet-1034	66	26	the	the	DET
admet-1034	66	27	log	log	NOUN
admet-1034	66	28	kw	kw	INTJ
admet-1034	66	29	iam	iam	PROPN
admet-1034	66	30	expected	expect	VERB
admet-1034	66	31	for	for	ADP
admet-1034	66	32	neutral	neutral	ADJ
admet-1034	66	33	isolipophilic	isolipophilic	ADJ
admet-1034	66	34	molecules	molecule	NOUN
admet-1034	66	35	.	.	PUNCT
admet-1034	67	1	indeed	indeed	ADV
admet-1034	67	2	,	,	PUNCT
admet-1034	67	3	as	as	SCONJ
admet-1034	67	4	reported	report	VERB
admet-1034	67	5	in	in	ADP
admet-1034	67	6	our	our	PRON
admet-1034	67	7	previous	previous	ADJ
admet-1034	67	8	studies	study	NOUN
admet-1034	67	9	[	[	X
admet-1034	67	10	14,15	14,15	NUM
admet-1034	67	11	]	]	PUNCT
admet-1034	67	12	,	,	PUNCT
admet-1034	67	13	iam	iam	PROPN
admet-1034	67	14	retention	retention	NOUN
admet-1034	67	15	data	datum	NOUN
admet-1034	67	16	on	on	ADP
admet-1034	67	17	both	both	DET
admet-1034	67	18	iam	iam	PROPN
admet-1034	67	19	phases	phase	NOUN
admet-1034	67	20	relate	relate	VERB
admet-1034	67	21	unambiguously	unambiguously	ADV
admet-1034	67	22	with	with	ADP
admet-1034	67	23	log	log	NOUN
admet-1034	67	24	p	p	NOUN
admet-1034	67	25	values	value	NOUN
admet-1034	67	26	of	of	ADP
admet-1034	67	27	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	67	28	https://www.ddl.unimi.it/vegaol/logkwiam.htm	https://www.ddl.unimi.it/vegaol/logkwiam.htm	PROPN
admet-1034	67	29	grumetto	grumetto	PROPN
admet-1034	67	30	and	and	CCONJ
admet-1034	67	31	russo	russo	PROPN
admet-1034	67	32	admet	admet	PROPN
admet-1034	67	33	&	&	CCONJ
admet-1034	67	34	dmpk	dmpk	PROPN
admet-1034	67	35	9(4	9(4	PROPN
admet-1034	67	36	)	)	PUNCT
admet-1034	67	37	(	(	PUNCT
admet-1034	67	38	2021	2021	NUM
admet-1034	67	39	)	)	PUNCT
admet-1034	67	40	267	267	NUM
admet-1034	67	41	-	-	SYM
admet-1034	67	42	281	281	NUM
admet-1034	67	43	270	270	NUM
admet-1034	67	44	structurally	structurally	ADV
admet-1034	67	45	non	non	ADJ
admet-1034	67	46	-	-	ADJ
admet-1034	67	47	related	related	ADJ
admet-1034	67	48	neutral	neutral	ADJ
admet-1034	67	49	compounds	compound	NOUN
admet-1034	67	50	,	,	PUNCT
admet-1034	67	51	in	in	ADP
admet-1034	67	52	the	the	DET
admet-1034	67	53	log	log	NOUN
admet-1034	67	54	p	p	NOUN
admet-1034	67	55	range	range	NOUN
admet-1034	67	56	1.0–4.8	1.0–4.8	NUM
admet-1034	67	57	.	.	PUNCT
admet-1034	68	1	these	these	DET
admet-1034	68	2	relationships	relationship	NOUN
admet-1034	68	3	are	be	AUX
admet-1034	68	4	expressed	express	VERB
admet-1034	68	5	by	by	ADP
admet-1034	68	6	the	the	DET
admet-1034	68	7	following	follow	VERB
admet-1034	68	8	equations	equation	NOUN
admet-1034	68	9	:	:	PUNCT
admet-1034	68	10	log	log	VERB
admet-1034	68	11	kw	kw	INTJ
admet-1034	68	12	iam.mg	iam.mg	PROPN
admet-1034	69	1	=	=	PUNCT
admet-1034	69	2	0.792	0.792	NUM
admet-1034	69	3	(	(	PUNCT
admet-1034	69	4	±0.038	±0.038	NOUN
admet-1034	69	5	)	)	PUNCT
admet-1034	69	6	log	log	NOUN
admet-1034	69	7	p	p	PROPN
admet-1034	69	8	0.732(±0.105	0.732(±0.105	PROPN
admet-1034	69	9	)	)	PUNCT
admet-1034	69	10	(	(	PUNCT
admet-1034	69	11	4	4	X
admet-1034	69	12	)	)	PUNCT
admet-1034	69	13	n	n	NOUN
admet-1034	69	14	=	=	SYM
admet-1034	69	15	36	36	NUM
admet-1034	69	16	r2	r2	NOUN
admet-1034	69	17	=	=	PUNCT
admet-1034	69	18	0.926	0.926	NUM
admet-1034	69	19	s	s	NOUN
admet-1034	69	20	=	=	SYM
admet-1034	69	21	0.248	0.248	NUM
admet-1034	69	22	f1	f1	NOUN
admet-1034	69	23	,	,	PUNCT
admet-1034	69	24	34	34	NUM
admet-1034	69	25	=	=	SYM
admet-1034	69	26	422.40	422.40	NUM
admet-1034	69	27	f1	f1	NOUN
admet-1034	69	28	,	,	PUNCT
admet-1034	69	29	34	34	NUM
admet-1034	69	30	α,0.001	α,0.001	ADJ
admet-1034	69	31	=	=	SYM
admet-1034	69	32	12.90	12.90	NUM
admet-1034	69	33	log	log	NOUN
admet-1034	69	34	kw	kw	INTJ
admet-1034	69	35	iam.dd2	iam.dd2	NOUN
admet-1034	69	36	=	=	NOUN
admet-1034	69	37	0.934	0.934	NUM
admet-1034	69	38	(	(	PUNCT
admet-1034	69	39	±0.038	±0.038	NOUN
admet-1034	69	40	)	)	PUNCT
admet-1034	69	41	log	log	NOUN
admet-1034	69	42	p	p	NOUN
admet-1034	69	43	0.883(±0.104	0.883(±0.104	PROPN
admet-1034	69	44	)	)	PUNCT
admet-1034	69	45	(	(	PUNCT
admet-1034	69	46	5	5	X
admet-1034	69	47	)	)	PUNCT
admet-1034	69	48	n	n	NOUN
admet-1034	69	49	=	=	SYM
admet-1034	69	50	36	36	NUM
admet-1034	69	51	r2	r2	NOUN
admet-1034	69	52	=	=	PUNCT
admet-1034	69	53	0.946	0.946	NUM
admet-1034	69	54	s	s	NOUN
admet-1034	69	55	=	=	SYM
admet-1034	69	56	0.246	0.246	NUM
admet-1034	69	57	f1	f1	NOUN
admet-1034	69	58	,	,	PUNCT
admet-1034	69	59	34	34	NUM
admet-1034	69	60	=	=	SYM
admet-1034	69	61	595.74	595.74	NUM
admet-1034	69	62	f1	f1	NOUN
admet-1034	69	63	,	,	PUNCT
admet-1034	69	64	34	34	NUM
admet-1034	69	65	α,0.001	α,0.001	ADJ
admet-1034	69	66	=	=	NOUN
admet-1034	69	67	12.90	12.90	NUM
admet-1034	69	68	for	for	ADP
admet-1034	69	69	acidic	acidic	ADJ
admet-1034	69	70	compounds	compound	NOUN
admet-1034	69	71	,	,	PUNCT
admet-1034	69	72	analogously	analogously	ADV
admet-1034	69	73	to	to	ADP
admet-1034	69	74	what	what	PRON
admet-1034	69	75	was	be	AUX
admet-1034	69	76	reported	report	VERB
admet-1034	69	77	in	in	ADP
admet-1034	69	78	our	our	PRON
admet-1034	69	79	previous	previous	ADJ
admet-1034	69	80	study	study	NOUN
admet-1034	69	81	[	[	X
admet-1034	69	82	15	15	NUM
admet-1034	69	83	]	]	PUNCT
admet-1034	69	84	,	,	PUNCT
admet-1034	69	85	log	log	VERB
admet-1034	69	86	d7.4	d7.4	NUM
admet-1034	69	87	rather	rather	ADV
admet-1034	69	88	than	than	ADP
admet-1034	69	89	log	log	VERB
admet-1034	69	90	pn	pn	PROPN
admet-1034	69	91	was	be	AUX
admet-1034	69	92	used	use	VERB
admet-1034	69	93	for	for	ADP
admet-1034	69	94	the	the	DET
admet-1034	69	95	computation	computation	NOUN
admet-1034	69	96	of	of	ADP
admet-1034	69	97	delta	delta	NOUN
admet-1034	69	98	values	value	NOUN
admet-1034	69	99	in	in	ADP
admet-1034	69	100	equations	equation	NOUN
admet-1034	69	101	(	(	PUNCT
admet-1034	69	102	4	4	NUM
admet-1034	69	103	)	)	PUNCT
admet-1034	69	104	and	and	CCONJ
admet-1034	69	105	(	(	PUNCT
admet-1034	69	106	5	5	NUM
admet-1034	69	107	)	)	PUNCT
admet-1034	69	108	.	.	PUNCT
admet-1034	70	1	their	their	PRON
admet-1034	70	2	values	value	NOUN
admet-1034	70	3	were	be	AUX
admet-1034	70	4	therefore	therefore	ADV
admet-1034	70	5	named	name	VERB
admet-1034	70	6	’log	’log	PROPN
admet-1034	70	7	kw	kw	PROPN
admet-1034	70	8	iam	iam	PROPN
admet-1034	70	9	values	value	VERB
admet-1034	70	10	to	to	PART
admet-1034	70	11	avoid	avoid	VERB
admet-1034	70	12	any	any	DET
admet-1034	70	13	ambiguity	ambiguity	NOUN
admet-1034	70	14	.	.	PUNCT
admet-1034	71	1	molecular	molecular	ADJ
admet-1034	71	2	modeling	model	VERB
admet-1034	71	3	an	an	DET
admet-1034	71	4	ample	ample	ADJ
admet-1034	71	5	array	array	NOUN
admet-1034	71	6	(	(	PUNCT
admet-1034	71	7	>	>	X
admet-1034	71	8	1,600	1,600	NUM
admet-1034	71	9	)	)	PUNCT
admet-1034	71	10	of	of	ADP
admet-1034	71	11	physico	physico	NOUN
admet-1034	71	12	-	-	PUNCT
admet-1034	71	13	chemical	chemical	NOUN
admet-1034	71	14	descriptors	descriptor	NOUN
admet-1034	71	15	,	,	PUNCT
admet-1034	71	16	subdivided	subdivide	VERB
admet-1034	71	17	into	into	ADP
admet-1034	71	18	20	20	NUM
admet-1034	71	19	logical	logical	ADJ
admet-1034	71	20	blocks	block	NOUN
admet-1034	71	21	(	(	PUNCT
admet-1034	71	22	atom	atom	NOUN
admet-1034	71	23	type	type	NOUN
admet-1034	71	24	,	,	PUNCT
admet-1034	71	25	functional	functional	ADJ
admet-1034	71	26	group	group	NOUN
admet-1034	71	27	,	,	PUNCT
admet-1034	71	28	fragment	fragment	NOUN
admet-1034	71	29	counts	count	NOUN
admet-1034	71	30	,	,	PUNCT
admet-1034	71	31	topological	topological	ADJ
admet-1034	71	32	and	and	CCONJ
admet-1034	71	33	geometrical	geometrical	ADJ
admet-1034	71	34	descriptors	descriptor	NOUN
admet-1034	71	35	)	)	PUNCT
admet-1034	71	36	,	,	PUNCT
admet-1034	71	37	were	be	AUX
admet-1034	71	38	calculated	calculate	VERB
admet-1034	71	39	by	by	ADP
admet-1034	71	40	the	the	DET
admet-1034	71	41	web	web	NOUN
admet-1034	71	42	service	service	NOUN
admet-1034	71	43	e	e	NOUN
admet-1034	71	44	-	-	NOUN
admet-1034	71	45	dragon	dragon	NOUN
admet-1034	71	46	1.0	1.0	NUM
admet-1034	72	1	[	[	X
admet-1034	72	2	32	32	NUM
admet-1034	72	3	]	]	PUNCT
admet-1034	72	4	.	.	PUNCT
admet-1034	73	1	in	in	ADP
admet-1034	73	2	brief	brief	NOUN
admet-1034	73	3	,	,	PUNCT
admet-1034	73	4	the	the	DET
admet-1034	73	5	molecules	molecule	NOUN
admet-1034	73	6	were	be	AUX
admet-1034	73	7	input	input	VERB
admet-1034	73	8	as	as	ADP
admet-1034	73	9	smiles	smile	NOUN
admet-1034	73	10	code	code	NOUN
admet-1034	73	11	in	in	ADP
admet-1034	73	12	a	a	DET
admet-1034	73	13	text	text	NOUN
admet-1034	73	14	document	document	NOUN
admet-1034	73	15	and	and	CCONJ
admet-1034	73	16	converted	convert	VERB
admet-1034	73	17	by	by	ADP
admet-1034	73	18	the	the	DET
admet-1034	73	19	integrated	integrated	ADJ
admet-1034	73	20	applet	applet	NOUN
admet-1034	73	21	corina	corina	PROPN
admet-1034	73	22	in	in	ADP
admet-1034	73	23	3d	3d	PROPN
admet-1034	73	24	before	before	SCONJ
admet-1034	73	25	all	all	DET
admet-1034	73	26	the	the	DET
admet-1034	73	27	indices	index	NOUN
admet-1034	73	28	were	be	AUX
admet-1034	73	29	computed	compute	VERB
admet-1034	73	30	.	.	PUNCT
admet-1034	74	1	the	the	DET
admet-1034	74	2	quantitative	quantitative	ADJ
admet-1034	74	3	structure	structure	NOUN
admet-1034	74	4	-	-	PUNCT
admet-1034	74	5	property	property	NOUN
admet-1034	74	6	relationship	relationship	NOUN
admet-1034	74	7	(	(	PUNCT
admet-1034	74	8	qspr	qspr	NOUN
admet-1034	74	9	)	)	PUNCT
admet-1034	74	10	models	model	NOUN
admet-1034	74	11	were	be	AUX
admet-1034	74	12	obtained	obtain	VERB
admet-1034	74	13	by	by	ADP
admet-1034	74	14	the	the	DET
admet-1034	74	15	automatic	automatic	ADJ
admet-1034	74	16	stepwise	stepwise	NOUN
admet-1034	74	17	approach	approach	NOUN
admet-1034	74	18	implemented	implement	VERB
admet-1034	74	19	in	in	ADP
admet-1034	74	20	the	the	DET
admet-1034	74	21	“	"	PUNCT
admet-1034	74	22	automatic	automatic	ADJ
admet-1034	74	23	linear	linear	PROPN
admet-1034	74	24	regression	regression	NOUN
admet-1034	74	25	”	"	PUNCT
admet-1034	74	26	script	script	NOUN
admet-1034	74	27	of	of	ADP
admet-1034	74	28	vega	vega	PROPN
admet-1034	74	29	zz	zz	PROPN
admet-1034	74	30	software	software	PROPN
admet-1034	74	31	[	[	X
admet-1034	74	32	33	33	NUM
admet-1034	74	33	]	]	PUNCT
admet-1034	74	34	,	,	PUNCT
admet-1034	74	35	calculating	calculate	VERB
admet-1034	74	36	regression	regression	NOUN
admet-1034	74	37	models	model	NOUN
admet-1034	74	38	,	,	PUNCT
admet-1034	74	39	including	include	VERB
admet-1034	74	40	from	from	ADP
admet-1034	74	41	one	one	NUM
admet-1034	74	42	to	to	ADP
admet-1034	74	43	five	five	NUM
admet-1034	74	44	independent	independent	ADJ
admet-1034	74	45	variables	variable	NOUN
admet-1034	74	46	.	.	PUNCT
admet-1034	75	1	the	the	DET
admet-1034	75	2	predictive	predictive	ADJ
admet-1034	75	3	strength	strength	NOUN
admet-1034	75	4	of	of	ADP
admet-1034	75	5	the	the	DET
admet-1034	75	6	best	good	ADJ
admet-1034	75	7	equation	equation	NOUN
admet-1034	75	8	was	be	AUX
admet-1034	75	9	evaluated	evaluate	VERB
admet-1034	75	10	by	by	ADP
admet-1034	75	11	leave	leave	VERB
admet-1034	75	12	-	-	PUNCT
admet-1034	75	13	one	one	NUM
admet-1034	75	14	-	-	PUNCT
admet-1034	75	15	out	out	NOUN
admet-1034	75	16	(	(	PUNCT
admet-1034	75	17	loo	loo	NOUN
admet-1034	75	18	)	)	PUNCT
admet-1034	75	19	cross	cross	NOUN
admet-1034	75	20	-	-	NOUN
admet-1034	75	21	validation	validation	NOUN
admet-1034	75	22	.	.	PUNCT
admet-1034	76	1	the	the	DET
admet-1034	76	2	regression	regression	NOUN
admet-1034	76	3	coefficients	coefficient	NOUN
admet-1034	76	4	were	be	AUX
admet-1034	76	5	calculated	calculate	VERB
admet-1034	76	6	to	to	PART
admet-1034	76	7	evaluate	evaluate	VERB
admet-1034	76	8	the	the	DET
admet-1034	76	9	set	set	NOUN
admet-1034	76	10	in	in	ADP
admet-1034	76	11	terms	term	NOUN
admet-1034	76	12	of	of	ADP
admet-1034	76	13	the	the	DET
admet-1034	76	14	standard	standard	ADJ
admet-1034	76	15	deviation	deviation	NOUN
admet-1034	76	16	of	of	ADP
admet-1034	76	17	errors	error	NOUN
admet-1034	76	18	(	(	PUNCT
admet-1034	76	19	se	se	X
admet-1034	76	20	)	)	PUNCT
admet-1034	76	21	,	,	PUNCT
admet-1034	76	22	regression	regression	NOUN
admet-1034	76	23	coefficients	coefficient	NOUN
admet-1034	76	24	(	(	PUNCT
admet-1034	76	25	r2	r2	PROPN
admet-1034	76	26	is	be	AUX
admet-1034	76	27	the	the	DET
admet-1034	76	28	square	square	NOUN
admet-1034	76	29	of	of	ADP
admet-1034	76	30	the	the	DET
admet-1034	76	31	correlation	correlation	NOUN
admet-1034	76	32	coefficient	coefficient	NOUN
admet-1034	76	33	,	,	PUNCT
admet-1034	76	34	q2	q2	PROPN
admet-1034	76	35	is	be	AUX
admet-1034	76	36	the	the	DET
admet-1034	76	37	square	square	NOUN
admet-1034	76	38	of	of	ADP
admet-1034	76	39	the	the	DET
admet-1034	76	40	correlation	correlation	NOUN
admet-1034	76	41	coefficient	coefficient	NOUN
admet-1034	76	42	after	after	ADP
admet-1034	76	43	cross	cross	NOUN
admet-1034	76	44	-	-	NOUN
admet-1034	76	45	validation	validation	NOUN
admet-1034	76	46	)	)	PUNCT
admet-1034	76	47	,	,	PUNCT
admet-1034	76	48	intercept	intercept	PROPN
admet-1034	76	49	,	,	PUNCT
admet-1034	76	50	fisher	fisher	PROPN
admet-1034	76	51	statistic	statistic	PROPN
admet-1034	76	52	for	for	ADP
admet-1034	76	53	the	the	DET
admet-1034	76	54	regression	regression	NOUN
admet-1034	76	55	(	(	PUNCT
admet-1034	76	56	f	f	X
admet-1034	76	57	)	)	PUNCT
admet-1034	76	58	,	,	PUNCT
admet-1034	76	59	probability	probability	NOUN
admet-1034	76	60	(	(	PUNCT
admet-1034	76	61	p	p	NOUN
admet-1034	76	62	)	)	PUNCT
admet-1034	76	63	and	and	CCONJ
admet-1034	76	64	amemiya	amemiya	NOUN
admet-1034	76	65	prediction	prediction	NOUN
admet-1034	76	66	criterion	criterion	NOUN
admet-1034	76	67	(	(	PUNCT
admet-1034	76	68	pc	pc	NOUN
admet-1034	76	69	)	)	PUNCT
admet-1034	76	70	.	.	PUNCT
admet-1034	77	1	descriptors	descriptor	NOUN
admet-1034	77	2	with	with	ADP
admet-1034	77	3	too	too	ADV
admet-1034	77	4	low	low	ADJ
admet-1034	77	5	regression	regression	NOUN
admet-1034	77	6	coefficient	coefficient	NOUN
admet-1034	77	7	(	(	PUNCT
admet-1034	77	8	r2	r2	PROPN
admet-1034	77	9	<	<	X
admet-1034	77	10	0.1	0.1	NUM
admet-1034	77	11	)	)	PUNCT
admet-1034	77	12	were	be	AUX
admet-1034	77	13	excluded	exclude	VERB
admet-1034	77	14	,	,	PUNCT
admet-1034	77	15	and	and	CCONJ
admet-1034	77	16	collinear	collinear	ADJ
admet-1034	77	17	descriptors	descriptor	NOUN
admet-1034	77	18	were	be	AUX
admet-1034	77	19	detected	detect	VERB
admet-1034	77	20	by	by	ADP
admet-1034	77	21	evaluating	evaluate	VERB
admet-1034	77	22	the	the	DET
admet-1034	77	23	variance	variance	NOUN
admet-1034	77	24	inflation	inflation	NOUN
admet-1034	77	25	factor	factor	NOUN
admet-1034	77	26	(	(	PUNCT
admet-1034	77	27	vif	vif	NOUN
admet-1034	77	28	)	)	PUNCT
admet-1034	77	29	whose	whose	DET
admet-1034	77	30	threshold	threshold	NOUN
admet-1034	77	31	value	value	NOUN
admet-1034	77	32	was	be	AUX
admet-1034	77	33	set	set	VERB
admet-1034	77	34	to	to	ADP
admet-1034	77	35	5	5	NUM
admet-1034	77	36	.	.	PUNCT
admet-1034	78	1	data	datum	NOUN
admet-1034	78	2	handling	handle	VERB
admet-1034	78	3	data	datum	NOUN
admet-1034	78	4	were	be	AUX
admet-1034	78	5	input	input	NOUN
admet-1034	78	6	in	in	ADP
admet-1034	78	7	a	a	DET
admet-1034	78	8	spreadsheet	spreadsheet	NOUN
admet-1034	78	9	and	and	CCONJ
admet-1034	78	10	data	datum	NOUN
admet-1034	78	11	points	point	NOUN
admet-1034	78	12	were	be	AUX
admet-1034	78	13	plotted	plot	VERB
admet-1034	78	14	from	from	ADP
admet-1034	78	15	microsoft	microsoft	PROPN
admet-1034	78	16	excel	excel	PROPN
admet-1034	78	17	,	,	PUNCT
admet-1034	78	18	part	part	NOUN
admet-1034	78	19	of	of	ADP
admet-1034	78	20	the	the	DET
admet-1034	78	21	microsoft	microsoft	PROPN
admet-1034	78	22	office	office	PROPN
admet-1034	78	23	365	365	NUM
admet-1034	78	24	suite	suite	NOUN
admet-1034	78	25	of	of	ADP
admet-1034	78	26	programs	program	NOUN
admet-1034	78	27	.	.	PUNCT
admet-1034	79	1	results	result	NOUN
admet-1034	79	2	and	and	CCONJ
admet-1034	79	3	discussion	discussion	NOUN
admet-1034	79	4	c/’log	c/’log	NOUN
admet-1034	79	5	kw	kw	PROPN
admet-1034	79	6	iam	iam	PROPN
admet-1034	79	7	:	:	PUNCT
admet-1034	79	8	simple	simple	ADJ
admet-1034	79	9	linear	linear	ADJ
admet-1034	79	10	regression	regression	NOUN
admet-1034	79	11	in	in	ADP
admet-1034	79	12	our	our	PRON
admet-1034	79	13	previous	previous	ADJ
admet-1034	79	14	studies	study	NOUN
admet-1034	79	15	[	[	X
admet-1034	79	16	14	14	NUM
admet-1034	79	17	-	-	SYM
admet-1034	79	18	19	19	NUM
admet-1034	79	19	,	,	PUNCT
admet-1034	79	20	34	34	NUM
admet-1034	79	21	]	]	PUNCT
admet-1034	79	22	,	,	PUNCT
admet-1034	79	23	/’log	/’log	PROPN
admet-1034	79	24	kw	kw	PROPN
admet-1034	79	25	iam	iam	PROPN
admet-1034	79	26	values	value	NOUN
admet-1034	79	27	were	be	AUX
admet-1034	79	28	found	find	VERB
admet-1034	79	29	inversely	inversely	ADV
admet-1034	79	30	related	relate	VERB
admet-1034	79	31	to	to	ADP
admet-1034	79	32	the	the	DET
admet-1034	79	33	passage	passage	NOUN
admet-1034	79	34	of	of	ADP
admet-1034	79	35	complex	complex	ADJ
admet-1034	79	36	biological	biological	ADJ
admet-1034	79	37	barriers	barrier	NOUN
admet-1034	79	38	,	,	PUNCT
admet-1034	79	39	such	such	ADJ
admet-1034	79	40	as	as	ADP
admet-1034	79	41	the	the	DET
admet-1034	79	42	bbb	bbb	NOUN
admet-1034	79	43	and	and	CCONJ
admet-1034	79	44	the	the	DET
admet-1034	79	45	intestinal	intestinal	ADJ
admet-1034	79	46	wall	wall	NOUN
admet-1034	79	47	.	.	PUNCT
admet-1034	80	1	the	the	DET
admet-1034	80	2	calculation	calculation	NOUN
admet-1034	80	3	of	of	ADP
admet-1034	80	4	/’log	/’log	PROPN
admet-1034	80	5	kw	kw	PROPN
admet-1034	80	6	iam	iam	PROPN
admet-1034	80	7	parameters	parameter	NOUN
admet-1034	80	8	are	be	AUX
admet-1034	80	9	based	base	VERB
admet-1034	80	10	on	on	ADP
admet-1034	80	11	two	two	NUM
admet-1034	80	12	physico	physico	NOUN
admet-1034	80	13	-	-	PUNCT
admet-1034	80	14	chemical	chemical	NOUN
admet-1034	80	15	properties	property	NOUN
admet-1034	80	16	,	,	PUNCT
admet-1034	80	17	i.e.	i.e.	X
admet-1034	80	18	,	,	PUNCT
admet-1034	80	19	n	n	CCONJ
admet-1034	80	20	-	-	PUNCT
admet-1034	80	21	octanol	octanol	NOUN
admet-1034	80	22	/	/	SYM
admet-1034	80	23	water	water	NOUN
admet-1034	80	24	lipophilicity	lipophilicity	NOUN
admet-1034	80	25	either	either	ADV
admet-1034	80	26	of	of	ADP
admet-1034	80	27	the	the	DET
admet-1034	80	28	neutral	neutral	ADJ
admet-1034	80	29	species	specie	NOUN
admet-1034	80	30	(	(	PUNCT
admet-1034	80	31	giving	give	VERB
admet-1034	80	32	log	log	PROPN
admet-1034	80	33	kw	kw	PROPN
admet-1034	80	34	iam	iam	PROPN
admet-1034	80	35	)	)	PUNCT
admet-1034	80	36	or	or	CCONJ
admet-1034	80	37	of	of	ADP
admet-1034	80	38	the	the	DET
admet-1034	80	39	mixture	mixture	NOUN
admet-1034	80	40	of	of	ADP
admet-1034	80	41	the	the	DET
admet-1034	80	42	species	specie	NOUN
admet-1034	80	43	at	at	ADP
admet-1034	80	44	the	the	DET
admet-1034	80	45	physiological	physiological	ADJ
admet-1034	80	46	ph	ph	VERB
admet-1034	80	47	,	,	PUNCT
admet-1034	80	48	i.e.	i.e.	X
admet-1034	80	49	,	,	PUNCT
admet-1034	80	50	7.4	7.4	NUM
admet-1034	80	51	(	(	PUNCT
admet-1034	80	52	giving	give	VERB
admet-1034	80	53	’log	’log	PROPN
admet-1034	80	54	kw	kw	PROPN
admet-1034	80	55	iam	iam	PROPN
admet-1034	80	56	)	)	PUNCT
admet-1034	80	57	and	and	CCONJ
admet-1034	80	58	the	the	DET
admet-1034	80	59	affinity	affinity	NOUN
admet-1034	80	60	of	of	ADP
admet-1034	80	61	the	the	DET
admet-1034	80	62	compound	compound	NOUN
admet-1034	80	63	for	for	ADP
admet-1034	80	64	iam	iam	PROPN
admet-1034	80	65	phases	phase	NOUN
admet-1034	80	66	.	.	PUNCT
admet-1034	81	1	indeed	indeed	ADV
admet-1034	81	2	,	,	PUNCT
admet-1034	81	3	in	in	ADP
admet-1034	81	4	our	our	PRON
admet-1034	81	5	previous	previous	ADJ
admet-1034	81	6	studies	study	NOUN
admet-1034	81	7	[	[	X
admet-1034	81	8	14	14	NUM
admet-1034	81	9	-	-	SYM
admet-1034	81	10	16	16	NUM
admet-1034	81	11	]	]	PUNCT
admet-1034	81	12	,	,	PUNCT
admet-1034	81	13	we	we	PRON
admet-1034	81	14	verified	verify	VERB
admet-1034	81	15	that	that	SCONJ
admet-1034	81	16	for	for	ADP
admet-1034	81	17	acidic	acidic	ADJ
admet-1034	81	18	compounds	compound	NOUN
admet-1034	81	19	,	,	PUNCT
admet-1034	81	20	significant	significant	ADJ
admet-1034	81	21	relationships	relationship	NOUN
admet-1034	81	22	vs.	vs.	ADP
admet-1034	81	23	log	log	NOUN
admet-1034	81	24	bb	bb	NUM
admet-1034	81	25	data	datum	NOUN
admet-1034	81	26	could	could	AUX
admet-1034	81	27	only	only	ADV
admet-1034	81	28	be	be	AUX
admet-1034	81	29	obtained	obtain	VERB
admet-1034	81	30	when	when	SCONJ
admet-1034	81	31	delta	delta	NOUN
admet-1034	81	32	parameters	parameter	NOUN
admet-1034	81	33	were	be	AUX
admet-1034	81	34	calculated	calculate	VERB
admet-1034	81	35	by	by	ADP
admet-1034	81	36	using	use	VERB
admet-1034	81	37	the	the	DET
admet-1034	81	38	lipophilicity	lipophilicity	NOUN
admet-1034	81	39	of	of	ADP
admet-1034	81	40	the	the	DET
admet-1034	81	41	mixture	mixture	NOUN
admet-1034	81	42	of	of	ADP
admet-1034	81	43	the	the	DET
admet-1034	81	44	species	specie	NOUN
admet-1034	81	45	present	present	ADJ
admet-1034	81	46	in	in	ADP
admet-1034	81	47	solution	solution	NOUN
admet-1034	81	48	at	at	ADP
admet-1034	81	49	the	the	DET
admet-1034	81	50	experimental	experimental	ADJ
admet-1034	81	51	ph	ph	VERB
admet-1034	81	52	,	,	PUNCT
admet-1034	81	53	i.e.	i.e.	X
admet-1034	81	54	,	,	PUNCT
admet-1034	81	55	log	log	NOUN
admet-1034	81	56	d7.4	d7.4	PROPN
admet-1034	81	57	,	,	PUNCT
admet-1034	81	58	rather	rather	ADV
admet-1034	81	59	than	than	ADP
admet-1034	81	60	that	that	PRON
admet-1034	81	61	of	of	ADP
admet-1034	81	62	the	the	DET
admet-1034	81	63	neutral	neutral	ADJ
admet-1034	81	64	species	specie	NOUN
admet-1034	81	65	,	,	PUNCT
admet-1034	81	66	i.e.	i.e.	X
admet-1034	81	67	,	,	PUNCT
admet-1034	81	68	log	log	PROPN
admet-1034	81	69	pn	pn	NOUN
admet-1034	81	70	.	.	PROPN
admet-1034	81	71	for	for	ADP
admet-1034	81	72	neutrals	neutral	NOUN
admet-1034	81	73	,	,	PUNCT
admet-1034	81	74	bases	basis	NOUN
admet-1034	81	75	and	and	CCONJ
admet-1034	81	76	ampholytes	ampholyte	NOUN
admet-1034	81	77	,	,	PUNCT
admet-1034	81	78	delta	delta	NOUN
admet-1034	81	79	parameters	parameter	NOUN
admet-1034	81	80	were	be	AUX
admet-1034	81	81	estimated	estimate	VERB
admet-1034	81	82	by	by	ADP
admet-1034	81	83	using	use	VERB
admet-1034	81	84	log	log	NOUN
admet-1034	81	85	pn	pn	PROPN
admet-1034	81	86	values	value	NOUN
admet-1034	81	87	instead	instead	ADV
admet-1034	81	88	.	.	PUNCT
admet-1034	82	1	for	for	ADP
admet-1034	82	2	consistency	consistency	NOUN
admet-1034	82	3	,	,	PUNCT
admet-1034	82	4	we	we	PRON
admet-1034	82	5	extended	extend	VERB
admet-1034	82	6	the	the	DET
admet-1034	82	7	same	same	ADJ
admet-1034	82	8	approach	approach	NOUN
admet-1034	82	9	to	to	ADP
admet-1034	82	10	delta	delta	NOUN
admet-1034	82	11	values	value	NOUN
admet-1034	82	12	surrogated	surrogate	VERB
admet-1034	82	13	in	in	ADP
admet-1034	82	14	silico	silico	NOUN
admet-1034	82	15	(	(	PUNCT
admet-1034	82	16	c/’log	c/’log	PROPN
admet-1034	82	17	kw	kw	PROPN
admet-1034	82	18	iam	iam	PROPN
admet-1034	82	19	)	)	PUNCT
admet-1034	82	20	.	.	PUNCT
admet-1034	83	1	however	however	ADV
admet-1034	83	2	,	,	PUNCT
admet-1034	83	3	while	while	SCONJ
admet-1034	83	4	there	there	PRON
admet-1034	83	5	are	be	VERB
admet-1034	83	6	plenty	plenty	NOUN
admet-1034	83	7	of	of	ADP
admet-1034	83	8	tools	tool	NOUN
admet-1034	83	9	available	available	ADJ
admet-1034	83	10	to	to	PART
admet-1034	83	11	surrogate	surrogate	VERB
admet-1034	83	12	log	log	NOUN
admet-1034	83	13	p	p	NOUN
admet-1034	83	14	values	value	NOUN
admet-1034	83	15	[	[	X
admet-1034	83	16	35	35	NUM
admet-1034	83	17	]	]	PUNCT
admet-1034	83	18	,	,	PUNCT
admet-1034	83	19	to	to	ADP
admet-1034	83	20	the	the	DET
admet-1034	83	21	best	good	ADJ
admet-1034	83	22	of	of	ADP
admet-1034	83	23	our	our	PRON
admet-1034	83	24	knowledge	knowledge	NOUN
admet-1034	83	25	,	,	PUNCT
admet-1034	83	26	the	the	DET
admet-1034	83	27	in	in	ADP
admet-1034	83	28	silico	silico	NOUN
admet-1034	83	29	platform	platform	NOUN
admet-1034	83	30	we	we	PRON
admet-1034	83	31	developed	develop	VERB
admet-1034	83	32	is	be	AUX
admet-1034	83	33	the	the	DET
admet-1034	83	34	only	only	ADJ
admet-1034	83	35	service	service	NOUN
admet-1034	83	36	that	that	PRON
admet-1034	83	37	predicts	predict	VERB
admet-1034	83	38	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	83	39	.	.	PUNCT
admet-1034	84	1	table	table	NOUN
admet-1034	84	2	admet	admet	PROPN
admet-1034	84	3	&	&	CCONJ
admet-1034	84	4	dmpk	dmpk	PROPN
admet-1034	84	5	9(4	9(4	PROPN
admet-1034	84	6	)	)	PUNCT
admet-1034	84	7	(	(	PUNCT
admet-1034	84	8	2021	2021	NUM
admet-1034	84	9	)	)	PUNCT
admet-1034	84	10	267	267	NUM
admet-1034	84	11	-	-	SYM
admet-1034	84	12	281	281	NUM
admet-1034	84	13	bbb	bbb	PROPN
admet-1034	84	14	passage	passage	NOUN
admet-1034	84	15	based	base	VERB
admet-1034	84	16	on	on	ADP
admet-1034	84	17	in	in	ADP
admet-1034	84	18	silico	silico	NOUN
admet-1034	84	19	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	84	20	doi	doi	NOUN
admet-1034	84	21	:	:	PUNCT
admet-1034	84	22	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	PUNCT
admet-1034	84	23	271	271	NUM
admet-1034	84	24	1	1	NUM
admet-1034	84	25	lists	list	NOUN
admet-1034	84	26	names	name	NOUN
admet-1034	84	27	,	,	PUNCT
admet-1034	84	28	chemical	chemical	ADJ
admet-1034	84	29	nature	nature	NOUN
admet-1034	84	30	(	(	PUNCT
admet-1034	84	31	a=	a=	ADV
admet-1034	84	32	acid	acid	ADJ
admet-1034	84	33	,	,	PUNCT
admet-1034	84	34	b	b	X
admet-1034	84	35	=	=	PRON
admet-1034	84	36	basic	basic	ADJ
admet-1034	84	37	,	,	PUNCT
admet-1034	84	38	bb=	bb=	VERB
admet-1034	84	39	bibasic	bibasic	ADJ
admet-1034	84	40	,	,	PUNCT
admet-1034	84	41	n=	n=	ADJ
admet-1034	84	42	neutral	neutral	ADJ
admet-1034	84	43	)	)	PUNCT
admet-1034	84	44	,	,	PUNCT
admet-1034	84	45	calculated	calculate	VERB
admet-1034	84	46	log	log	NOUN
admet-1034	84	47	kw	kw	INTJ
admet-1034	84	48	iam.mg	iam.mg	PROPN
admet-1034	84	49	and	and	CCONJ
admet-1034	84	50	log	log	VERB
admet-1034	84	51	kw	kw	INTJ
admet-1034	84	52	iam.dd2	iam.dd2	ADV
admet-1034	84	53	,	,	PUNCT
admet-1034	84	54	exp	exp	NOUN
admet-1034	84	55	log	log	NOUN
admet-1034	84	56	pn	pn	NOUN
admet-1034	84	57	,	,	PUNCT
admet-1034	84	58	clog	clog	VERB
admet-1034	84	59	pn	pn	PROPN
admet-1034	84	60	and	and	CCONJ
admet-1034	84	61	calculated	calculate	VERB
admet-1034	84	62	log	log	NOUN
admet-1034	84	63	d7.4	d7.4	PROPN
admet-1034	84	64	(	(	PUNCT
admet-1034	84	65	for	for	ADP
admet-1034	84	66	acids	acid	NOUN
admet-1034	84	67	only	only	ADV
admet-1034	84	68	)	)	PUNCT
admet-1034	84	69	values	value	NOUN
admet-1034	84	70	for	for	ADP
admet-1034	84	71	the	the	DET
admet-1034	84	72	dataset	dataset	NOUN
admet-1034	84	73	considered	consider	VERB
admet-1034	84	74	.	.	PUNCT
admet-1034	85	1	c/’log	c/’log	PROPN
admet-1034	85	2	kw	kw	PROPN
admet-1034	85	3	iam	iam	PROPN
admet-1034	85	4	values	value	NOUN
admet-1034	85	5	are	be	AUX
admet-1034	85	6	reported	report	VERB
admet-1034	85	7	in	in	ADP
admet-1034	85	8	table	table	NOUN
admet-1034	85	9	2	2	NUM
admet-1034	85	10	along	along	ADP
admet-1034	85	11	with	with	ADP
admet-1034	85	12	the	the	DET
admet-1034	85	13	experimental	experimental	ADJ
admet-1034	85	14	log	log	NOUN
admet-1034	85	15	bb	bb	NUM
admet-1034	85	16	values	value	NOUN
admet-1034	85	17	.	.	PUNCT
admet-1034	86	1	table	table	NOUN
admet-1034	86	2	1	1	NUM
admet-1034	86	3	.	.	PUNCT
admet-1034	87	1	names	name	NOUN
admet-1034	87	2	,	,	PUNCT
admet-1034	87	3	chemical	chemical	NOUN
admet-1034	87	4	nature	nature	NOUN
admet-1034	87	5	(	(	PUNCT
admet-1034	87	6	a=	a=	ADV
admet-1034	87	7	acid	acid	ADJ
admet-1034	87	8	,	,	PUNCT
admet-1034	87	9	b	b	X
admet-1034	87	10	=	=	PRON
admet-1034	87	11	basic	basic	ADJ
admet-1034	87	12	,	,	PUNCT
admet-1034	87	13	bb=	bb=	VERB
admet-1034	87	14	bibasic	bibasic	ADJ
admet-1034	87	15	,	,	PUNCT
admet-1034	87	16	n=	n=	ADJ
admet-1034	87	17	neutral	neutral	ADJ
admet-1034	87	18	)	)	PUNCT
admet-1034	87	19	,	,	PUNCT
admet-1034	87	20	calculated	calculate	VERB
admet-1034	87	21	log	log	NOUN
admet-1034	87	22	kw	kw	INTJ
admet-1034	87	23	iam.mg	iam.mg	PROPN
admet-1034	87	24	and	and	CCONJ
admet-1034	87	25	log	log	VERB
admet-1034	87	26	kw	kw	INTJ
admet-1034	87	27	iam.dd2	iam.dd2	ADV
admet-1034	87	28	,	,	PUNCT
admet-1034	87	29	exp	exp	NOUN
admet-1034	87	30	log	log	NOUN
admet-1034	87	31	p	p	NOUN
admet-1034	87	32	n	n	CCONJ
admet-1034	87	33	,	,	PUNCT
admet-1034	87	34	clog	clog	VERB
admet-1034	87	35	p	p	NOUN
admet-1034	87	36	n	n	NOUN
admet-1034	87	37	values	value	NOUN
admet-1034	87	38	for	for	ADP
admet-1034	87	39	the	the	DET
admet-1034	87	40	dataset	dataset	NOUN
admet-1034	87	41	considered	consider	VERB
admet-1034	87	42	.	.	PUNCT
admet-1034	88	1	molecule	molecule	NOUN
admet-1034	88	2	nature	nature	NOUN
admet-1034	88	3	clog	clog	VERB
admet-1034	88	4	kw	kw	NOUN
admet-1034	88	5	iam.mg	iam.mg	PROPN
admet-1034	88	6	clog	clog	VERB
admet-1034	88	7	kw	kw	INTJ
admet-1034	88	8	iam.dd2	iam.dd2	ADJ
admet-1034	88	9	exp	exp	NOUN
admet-1034	88	10	log	log	NOUN
admet-1034	88	11	p	p	NOUN
admet-1034	88	12	n	n	PROPN
admet-1034	88	13	[	[	X
admet-1034	88	14	36	36	NUM
admet-1034	88	15	]	]	PUNCT
admet-1034	88	16	clog	clog	NOUN
admet-1034	88	17	p	p	NOUN
admet-1034	88	18	n	n	PROPN
admet-1034	88	19	(	(	PUNCT
admet-1034	88	20	1	1	NUM
admet-1034	88	21	)	)	PUNCT
admet-1034	89	1	[	[	X
admet-1034	89	2	26	26	NUM
admet-1034	89	3	]	]	X
admet-1034	89	4	clog	clog	VERB
admet-1034	89	5	p	p	NOUN
admet-1034	89	6	n	n	X
admet-1034	89	7	(	(	PUNCT
admet-1034	89	8	2	2	NUM
admet-1034	89	9	)	)	PUNCT
admet-1034	90	1	[	[	X
admet-1034	90	2	37	37	NUM
admet-1034	90	3	]	]	PUNCT
admet-1034	90	4	clog	clog	NOUN
admet-1034	90	5	d	d	NOUN
admet-1034	90	6	7.4	7.4	NUM
admet-1034	91	1	[	[	X
admet-1034	91	2	37	37	NUM
admet-1034	91	3	]	]	SYM
admet-1034	91	4	1,1,1	1,1,1	NUM
admet-1034	91	5	-	-	PUNCT
admet-1034	91	6	trichloroethane	trichloroethane	NOUN
admet-1034	91	7	n	n	NOUN
admet-1034	91	8	1.063	1.063	NUM
admet-1034	91	9	1.247	1.247	NUM
admet-1034	91	10	2.49	2.49	NUM
admet-1034	91	11	2.45	2.45	NUM
admet-1034	91	12	2.04	2.04	NUM
admet-1034	91	13	1,2	1,2	NUM
admet-1034	91	14	-	-	PUNCT
admet-1034	91	15	dimethylbenzene	dimethylbenzene	NOUN
admet-1034	91	16	n	n	NOUN
admet-1034	91	17	1.400	1.400	NUM
admet-1034	91	18	1.635	1.635	NUM
admet-1034	91	19	3.12	3.12	NUM
admet-1034	91	20	3.16	3.16	NUM
admet-1034	91	21	2.98	2.98	NUM
admet-1034	91	22	1,4	1,4	NUM
admet-1034	91	23	-	-	PUNCT
admet-1034	91	24	dimethylbenzene	dimethylbenzene	NOUN
admet-1034	91	25	n	n	NOUN
admet-1034	91	26	1.421	1.421	NUM
admet-1034	91	27	1.599	1.599	NUM
admet-1034	91	28	3.15	3.15	NUM
admet-1034	91	29	3.15	3.15	NUM
admet-1034	91	30	2.98	2.98	NUM
admet-1034	91	31	1,7	1,7	NUM
admet-1034	91	32	-	-	PUNCT
admet-1034	91	33	dimethylxanthine	dimethylxanthine	VERB
admet-1034	91	34	a	a	PRON
admet-1034	91	35	-0.073	-0.073	PUNCT
admet-1034	91	36	-0.001	-0.001	NOUN
admet-1034	92	1	-0.22	-0.22	NUM
admet-1034	92	2	-0.63	-0.63	NUM
admet-1034	92	3	0.09	0.09	NUM
admet-1034	92	4	0.09	0.09	NUM
admet-1034	92	5	1	1	NUM
admet-1034	92	6	-	-	PUNCT
admet-1034	92	7	chloro-2,2,2trifluoroethane	chloro-2,2,2trifluoroethane	NOUN
admet-1034	92	8	n	n	NOUN
admet-1034	92	9	0.811	0.811	NUM
admet-1034	92	10	0.774	0.774	NUM
admet-1034	92	11	1.82	1.82	NUM
admet-1034	92	12	1.86	1.86	NUM
admet-1034	92	13	1	1	NUM
admet-1034	92	14	-	-	NUM
admet-1034	92	15	hydroxymidazolam	hydroxymidazolam	NOUN
admet-1034	92	16	n	n	CCONJ
admet-1034	92	17	1.839	1.839	NUM
admet-1034	92	18	2.043	2.043	NUM
admet-1034	92	19	3.09	3.09	NUM
admet-1034	92	20	2.9	2.9	NUM
admet-1034	92	21	2,2	2,2	NUM
admet-1034	92	22	-	-	PROPN
admet-1034	92	23	dimethylbutane	dimethylbutane	NOUN
admet-1034	92	24	n	n	ADV
admet-1034	92	25	1.283	1.283	NUM
admet-1034	92	26	1.578	1.578	NUM
admet-1034	92	27	3.82	3.82	NUM
admet-1034	92	28	3.74	3.74	NUM
admet-1034	92	29	2.85	2.85	NUM
admet-1034	92	30	2	2	NUM
admet-1034	92	31	-	-	PUNCT
admet-1034	92	32	methylpentane	methylpentane	NOUN
admet-1034	92	33	n	n	NOUN
admet-1034	92	34	1.388	1.388	NUM
admet-1034	92	35	1.706	1.706	NUM
admet-1034	92	36	3.21	3.21	NUM
admet-1034	92	37	3.66	3.66	NUM
admet-1034	92	38	2.82	2.82	NUM
admet-1034	92	39	3	3	NUM
admet-1034	92	40	-	-	PUNCT
admet-1034	92	41	methylhexane	methylhexane	NOUN
admet-1034	92	42	n	n	NOUN
admet-1034	92	43	1.561	1.561	NUM
admet-1034	92	44	1.949	1.949	NUM
admet-1034	92	45	4.18	4.18	NUM
admet-1034	92	46	3.21	3.21	NUM
admet-1034	92	47	3	3	NUM
admet-1034	92	48	-	-	PUNCT
admet-1034	92	49	methylpentane	methylpentane	NOUN
admet-1034	92	50	n	n	NOUN
admet-1034	92	51	1.292	1.292	NUM
admet-1034	92	52	1.599	1.599	NUM
admet-1034	92	53	3.60	3.60	NUM
admet-1034	92	54	3.98	3.98	NUM
admet-1034	92	55	2.82	2.82	NUM
admet-1034	92	56	4	4	NUM
admet-1034	92	57	-	-	NUM
admet-1034	92	58	hydroxymidazolam	hydroxymidazolam	NOUN
admet-1034	92	59	n	n	CCONJ
admet-1034	92	60	1.950	1.950	NUM
admet-1034	92	61	2.191	2.191	NUM
admet-1034	92	62	3.05	3.05	NUM
admet-1034	92	63	3.35	3.35	NUM
admet-1034	92	64	acetaminophen	acetaminophen	NOUN
admet-1034	92	65	n	n	ADV
admet-1034	92	66	0.184	0.184	NUM
admet-1034	92	67	0.302	0.302	NUM
admet-1034	92	68	0.91	0.91	NUM
admet-1034	92	69	0.51	0.51	NUM
admet-1034	92	70	1.09	1.09	NUM
admet-1034	92	71	acetone	acetone	NOUN
admet-1034	92	72	n	n	CCONJ
admet-1034	92	73	-0.247	-0.247	NUM
admet-1034	92	74	-0.359	-0.359	NOUN
admet-1034	92	75	-0.24	-0.24	NUM
admet-1034	92	76	-0.29	-0.29	NOUN
admet-1034	92	77	0.38	0.38	NUM
admet-1034	92	78	aminopyrine	aminopyrine	NOUN
admet-1034	92	79	n	n	CCONJ
admet-1034	92	80	1.045	1.045	NUM
admet-1034	92	81	1.349	1.349	NUM
admet-1034	92	82	1.00	1.00	NUM
admet-1034	92	83	0.94	0.94	NUM
admet-1034	92	84	1.60	1.60	NUM
admet-1034	92	85	amobarbital	amobarbital	NOUN
admet-1034	92	86	a	a	DET
admet-1034	92	87	0.899	0.899	NUM
admet-1034	92	88	1.181	1.181	NUM
admet-1034	92	89	2.07	2.07	NUM
admet-1034	92	90	1.87	1.87	NUM
admet-1034	92	91	1.86	1.86	NUM
admet-1034	92	92	1.60	1.60	NUM
admet-1034	92	93	antipyrine	antipyrine	NOUN
admet-1034	92	94	n	n	ADP
admet-1034	92	95	0.901	0.901	NUM
admet-1034	92	96	1.139	1.139	NUM
admet-1034	92	97	0.56	0.56	NUM
admet-1034	92	98	1.18	1.18	NUM
admet-1034	92	99	1.61	1.61	NUM
admet-1034	92	100	bretazenil	bretazenil	NOUN
admet-1034	92	101	n	n	ADP
admet-1034	92	102	2.103	2.103	NUM
admet-1034	92	103	2.447	2.447	NUM
admet-1034	92	104	3.05	3.05	NUM
admet-1034	92	105	2.29	2.29	NUM
admet-1034	92	106	cyclohexane	cyclohexane	NOUN
admet-1034	92	107	n	n	CCONJ
admet-1034	92	108	1.476	1.476	NUM
admet-1034	92	109	1.671	1.671	NUM
admet-1034	92	110	3.44	3.44	NUM
admet-1034	92	111	2.38	2.38	NUM
admet-1034	92	112	cyclopropane	cyclopropane	NOUN
admet-1034	92	113	n	n	ADP
admet-1034	92	114	0.284	0.284	NUM
admet-1034	92	115	0.105	0.105	NUM
admet-1034	92	116	1.72	1.72	NUM
admet-1034	92	117	1.56	1.56	NUM
admet-1034	92	118	1.19	1.19	NUM
admet-1034	92	119	desmonomethylpromazine	desmonomethylpromazine	NOUN
admet-1034	92	120	b	b	NOUN
admet-1034	92	121	2.287	2.287	NUM
admet-1034	92	122	2.703	2.703	NUM
admet-1034	92	123	4.28	4.28	NUM
admet-1034	92	124	3.68	3.68	NUM
admet-1034	92	125	didanosine	didanosine	NOUN
admet-1034	92	126	a	a	DET
admet-1034	92	127	-0.404	-0.404	NOUN
admet-1034	92	128	-0.294	-0.294	PUNCT
admet-1034	92	129	-1.24	-1.24	NOUN
admet-1034	92	130	-1.26	-1.26	NUM
admet-1034	92	131	-0.50	-0.50	NUM
admet-1034	92	132	-1.06	-1.06	NOUN
admet-1034	92	133	diethylene	diethylene	NOUN
admet-1034	92	134	glycol	glycol	NOUN
admet-1034	92	135	divinyl	divinyl	NOUN
admet-1034	92	136	ether	ether	NOUN
admet-1034	92	137	n	n	NOUN
admet-1034	92	138	-0.127	-0.127	NOUN
admet-1034	92	139	0.200	0.200	NUM
admet-1034	92	140	0.87	0.87	NUM
admet-1034	92	141	1.26	1.26	NUM
admet-1034	92	142	0.87	0.87	NUM
admet-1034	92	143	enflurane	enflurane	NOUN
admet-1034	92	144	n	n	ADP
admet-1034	92	145	1.075	1.075	NUM
admet-1034	92	146	1.203	1.203	NUM
admet-1034	92	147	2.10	2.10	NUM
admet-1034	92	148	2.24	2.24	NUM
admet-1034	92	149	2.42	2.42	NUM
admet-1034	92	150	ethanol	ethanol	NOUN
admet-1034	92	151	n	n	NOUN
admet-1034	92	152	-0.534	-0.534	NUM
admet-1034	92	153	-0.683	-0.683	PUNCT
admet-1034	92	154	-0.31	-0.31	NUM
admet-1034	92	155	-0.40	-0.40	NOUN
admet-1034	92	156	-0.22	-0.22	NOUN
admet-1034	92	157	ethyl	ethyl	PROPN
admet-1034	92	158	ether	ether	NOUN
admet-1034	92	159	n	n	CCONJ
admet-1034	92	160	0.162	0.162	NUM
admet-1034	92	161	0.308	0.308	NUM
admet-1034	92	162	0.89	0.89	NUM
admet-1034	92	163	1.12	1.12	NUM
admet-1034	92	164	0.70	0.70	NUM
admet-1034	92	165	ethylbenzene	ethylbenzene	NOUN
admet-1034	92	166	n	n	ADP
admet-1034	92	167	1.398	1.398	NUM
admet-1034	92	168	1.616	1.616	NUM
admet-1034	92	169	3.15	3.15	NUM
admet-1034	92	170	3.27	3.27	NUM
admet-1034	92	171	2.91	2.91	NUM
admet-1034	92	172	flunitrazepam	flunitrazepam	NOUN
admet-1034	92	173	n	n	ADP
admet-1034	92	174	1.621	1.621	NUM
admet-1034	92	175	1.739	1.739	NUM
admet-1034	92	176	2.06	2.06	NUM
admet-1034	92	177	2.20	2.20	NUM
admet-1034	92	178	2.58	2.58	NUM
admet-1034	92	179	fluroxene	fluroxene	NOUN
admet-1034	92	180	n	n	CCONJ
admet-1034	92	181	0.570	0.570	NUM
admet-1034	92	182	0.637	0.637	NUM
admet-1034	92	183	1.70	1.70	NUM
admet-1034	92	184	1.58	1.58	NUM
admet-1034	92	185	halothane	halothane	NOUN
admet-1034	92	186	n	n	PROPN
admet-1034	92	187	1.165	1.165	NUM
admet-1034	92	188	1.300	1.300	NUM
admet-1034	92	189	2.30	2.30	NUM
admet-1034	92	190	2.50	2.50	NUM
admet-1034	92	191	1.97	1.97	NUM
admet-1034	92	192	indinavir	indinavir	NOUN
admet-1034	92	193	bb	bb	NOUN
admet-1034	92	194	2.864	2.864	NUM
admet-1034	92	195	2.745	2.745	NUM
admet-1034	92	196	2.90	2.90	NUM
admet-1034	92	197	3.26	3.26	NUM
admet-1034	92	198	2.39	2.39	NUM
admet-1034	92	199	isobutyl	isobutyl	NOUN
admet-1034	92	200	alcohol	alcohol	NOUN
admet-1034	92	201	n	n	CCONJ
admet-1034	92	202	0.045	0.045	NUM
admet-1034	92	203	0.169	0.169	NUM
admet-1034	92	204	0.76	0.76	NUM
admet-1034	92	205	0.60	0.60	NUM
admet-1034	92	206	0.65	0.65	NUM
admet-1034	92	207	isoflurane	isoflurane	NOUN
admet-1034	92	208	n	n	ADV
admet-1034	92	209	1.074	1.074	NUM
admet-1034	92	210	1.207	1.207	NUM
admet-1034	92	211	2.30	2.30	NUM
admet-1034	92	212	2.48	2.48	NUM
admet-1034	92	213	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	92	214	grumetto	grumetto	NOUN
admet-1034	92	215	and	and	CCONJ
admet-1034	92	216	russo	russo	PROPN
admet-1034	92	217	admet	admet	PROPN
admet-1034	92	218	&	&	CCONJ
admet-1034	92	219	dmpk	dmpk	PROPN
admet-1034	92	220	9(4	9(4	PROPN
admet-1034	92	221	)	)	PUNCT
admet-1034	92	222	(	(	PUNCT
admet-1034	92	223	2021	2021	NUM
admet-1034	92	224	)	)	PUNCT
admet-1034	92	225	267	267	NUM
admet-1034	92	226	-	-	SYM
admet-1034	92	227	281	281	NUM
admet-1034	92	228	272	272	NUM
admet-1034	92	229	table	table	NOUN
admet-1034	92	230	1	1	NUM
admet-1034	92	231	.	.	NUM
admet-1034	92	232	continued	continue	VERB
admet-1034	92	233	…	…	PUNCT
admet-1034	92	234	molecule	molecule	NOUN
admet-1034	92	235	nature	nature	NOUN
admet-1034	92	236	clog	clog	VERB
admet-1034	92	237	kw	kw	NOUN
admet-1034	92	238	iam.mg	iam.mg	PROPN
admet-1034	92	239	clog	clog	VERB
admet-1034	92	240	kw	kw	INTJ
admet-1034	92	241	iam.dd2	iam.dd2	ADJ
admet-1034	92	242	exp	exp	NOUN
admet-1034	92	243	log	log	NOUN
admet-1034	92	244	p	p	NOUN
admet-1034	92	245	n	n	PROPN
admet-1034	92	246	[	[	X
admet-1034	92	247	36	36	NUM
admet-1034	92	248	]	]	PUNCT
admet-1034	92	249	clog	clog	NOUN
admet-1034	92	250	p	p	NOUN
admet-1034	92	251	n	n	PROPN
admet-1034	92	252	(	(	PUNCT
admet-1034	92	253	1	1	NUM
admet-1034	92	254	)	)	PUNCT
admet-1034	93	1	[	[	X
admet-1034	93	2	26	26	NUM
admet-1034	93	3	]	]	X
admet-1034	93	4	clog	clog	VERB
admet-1034	93	5	p	p	NOUN
admet-1034	93	6	n	n	X
admet-1034	93	7	(	(	PUNCT
admet-1034	93	8	2	2	NUM
admet-1034	93	9	)	)	PUNCT
admet-1034	94	1	[	[	X
admet-1034	94	2	37	37	NUM
admet-1034	94	3	]	]	PUNCT
admet-1034	94	4	clog	clog	NOUN
admet-1034	94	5	d	d	NOUN
admet-1034	94	6	7.4	7.4	NUM
admet-1034	94	7	[	[	SYM
admet-1034	94	8	37	37	NUM
admet-1034	94	9	]	]	PUNCT
admet-1034	94	10	isopropyl	isopropyl	NOUN
admet-1034	94	11	alcohol	alcohol	NOUN
admet-1034	94	12	n	n	CCONJ
admet-1034	94	13	-0.241	-0.241	X
admet-1034	94	14	-0.243	-0.243	PROPN
admet-1034	94	15	0.05	0.05	NUM
admet-1034	94	16	0.04	0.04	NUM
admet-1034	94	17	0.19	0.19	NUM
admet-1034	94	18	mesoridazine	mesoridazine	NOUN
admet-1034	94	19	b	b	PROPN
admet-1034	94	20	2.640	2.640	NUM
admet-1034	94	21	3.027	3.027	NUM
admet-1034	94	22	3.90	3.90	NUM
admet-1034	94	23	3.83	3.83	NUM
admet-1034	94	24	3.41	3.41	NUM
admet-1034	94	25	methoxyflurane	methoxyflurane	NOUN
admet-1034	94	26	n	n	ADV
admet-1034	94	27	0.864	0.864	NUM
admet-1034	94	28	1.070	1.070	NUM
admet-1034	94	29	2.21	2.21	NUM
admet-1034	94	30	2.01	2.01	NUM
admet-1034	94	31	1.91	1.91	NUM
admet-1034	94	32	methyl	methyl	NOUN
admet-1034	94	33	cyclopentane	cyclopentane	PROPN
admet-1034	94	34	n	n	CCONJ
admet-1034	94	35	1.140	1.140	NUM
admet-1034	94	36	1.347	1.347	NUM
admet-1034	94	37	3.37	3.37	NUM
admet-1034	94	38	3.15	3.15	NUM
admet-1034	94	39	2.31	2.31	NUM
admet-1034	94	40	methyl	methyl	NOUN
admet-1034	94	41	ethyl	ethyl	PROPN
admet-1034	94	42	ketone	ketone	NOUN
admet-1034	94	43	n	n	CCONJ
admet-1034	94	44	0.047	0.047	NUM
admet-1034	94	45	0.057	0.057	NUM
admet-1034	94	46	0.29	0.29	NUM
admet-1034	94	47	0.41	0.41	NUM
admet-1034	94	48	1.01	1.01	NUM
admet-1034	94	49	mirtazapine	mirtazapine	NOUN
admet-1034	94	50	b	b	PROPN
admet-1034	94	51	1.969	1.969	NUM
admet-1034	94	52	2.287	2.287	NUM
admet-1034	94	53	2.90	2.90	NUM
admet-1034	94	54	3.38	3.38	NUM
admet-1034	94	55	m	m	NOUN
admet-1034	94	56	-	-	PUNCT
admet-1034	94	57	xylene	xylene	NOUN
admet-1034	94	58	n	n	NOUN
admet-1034	94	59	1.410	1.410	NUM
admet-1034	94	60	1.641	1.641	NUM
admet-1034	94	61	3.20	3.20	NUM
admet-1034	94	62	3.15	3.15	NUM
admet-1034	94	63	2.98	2.98	NUM
admet-1034	94	64	nevirapine	nevirapine	ADJ
admet-1034	94	65	n	n	ADV
admet-1034	94	66	1.152	1.152	NUM
admet-1034	94	67	1.332	1.332	NUM
admet-1034	94	68	2.50	2.50	NUM
admet-1034	94	69	[	[	X
admet-1034	94	70	25	25	NUM
admet-1034	94	71	]	]	PUNCT
admet-1034	94	72	1.75	1.75	NUM
admet-1034	94	73	2.19	2.19	NUM
admet-1034	94	74	n	n	CCONJ
admet-1034	94	75	-	-	PUNCT
admet-1034	94	76	heptane	heptane	NOUN
admet-1034	94	77	n	n	NOUN
admet-1034	94	78	1.791	1.791	NUM
admet-1034	94	79	2.189	2.189	NUM
admet-1034	94	80	3.28	3.28	NUM
admet-1034	94	81	n	n	CCONJ
admet-1034	94	82	-	-	PUNCT
admet-1034	94	83	hexane	hexane	NOUN
admet-1034	94	84	n	n	NOUN
admet-1034	94	85	1.545	1.545	NUM
admet-1034	94	86	1.861	1.861	NUM
admet-1034	94	87	2.88	2.88	NUM
admet-1034	94	88	nordazepam	nordazepam	NOUN
admet-1034	94	89	n	n	NUM
admet-1034	94	90	1.838	1.838	NUM
admet-1034	94	91	2.055	2.055	NUM
admet-1034	94	92	2.79	2.79	NUM
admet-1034	94	93	3.24	3.24	NUM
admet-1034	94	94	northioridazine	northioridazine	NOUN
admet-1034	94	95	b	b	PROPN
admet-1034	94	96	3.120	3.120	NUM
admet-1034	94	97	3.607	3.607	NUM
admet-1034	94	98	5.29	5.29	NUM
admet-1034	94	99	5.1	5.1	NUM
admet-1034	94	100	n	n	CCONJ
admet-1034	94	101	-	-	PUNCT
admet-1034	94	102	pentane	pentane	NOUN
admet-1034	94	103	n	n	NOUN
admet-1034	94	104	1.299	1.299	NUM
admet-1034	94	105	1.529	1.529	NUM
admet-1034	94	106	2.49	2.49	NUM
admet-1034	94	107	quinidine	quinidine	NOUN
admet-1034	94	108	b	b	ADP
admet-1034	94	109	2.016	2.016	NUM
admet-1034	94	110	2.394	2.394	NUM
admet-1034	94	111	3.44	3.44	NUM
admet-1034	94	112	2.82	2.82	NUM
admet-1034	94	113	2.32	2.32	NUM
admet-1034	94	114	sulforidazine	sulforidazine	NOUN
admet-1034	94	115	b	b	PROPN
admet-1034	94	116	2.684	2.684	NUM
admet-1034	94	117	3.057	3.057	NUM
admet-1034	94	118	4.45	4.45	NUM
admet-1034	94	119	4.32	4.32	NUM
admet-1034	94	120	3.6	3.6	NUM
admet-1034	94	121	teflurane	teflurane	NOUN
admet-1034	94	122	n	n	PROPN
admet-1034	94	123	1.029	1.029	NUM
admet-1034	94	124	1.066	1.066	NUM
admet-1034	94	125	2.07	2.07	NUM
admet-1034	94	126	1.63	1.63	NUM
admet-1034	94	127	thioridazine	thioridazine	NOUN
admet-1034	94	128	b	b	ADP
admet-1034	94	129	3.318	3.318	NUM
admet-1034	94	130	3.816	3.816	NUM
admet-1034	94	131	5.90	5.90	NUM
admet-1034	94	132	5.93	5.93	NUM
admet-1034	94	133	5.48	5.48	NUM
admet-1034	94	134	thioxolone	thioxolone	NOUN
admet-1034	94	135	n	n	NOUN
admet-1034	94	136	2.414	2.414	NUM
admet-1034	94	137	2.834	2.834	NUM
admet-1034	94	138	3.90	3.90	NUM
admet-1034	94	139	2.69	2.69	NUM
admet-1034	94	140	2.93	2.93	NUM
admet-1034	94	141	tiotidine	tiotidine	NOUN
admet-1034	94	142	b	b	ADP
admet-1034	94	143	0.186	0.186	NUM
admet-1034	94	144	0.375	0.375	NUM
admet-1034	94	145	0.68	0.68	NUM
admet-1034	94	146	0.59	0.59	NUM
admet-1034	94	147	1.18	1.18	NUM
admet-1034	94	148	triazolam	triazolam	NOUN
admet-1034	94	149	n	n	CCONJ
admet-1034	94	150	2.102	2.102	NUM
admet-1034	94	151	2.365	2.365	NUM
admet-1034	94	152	2.42	2.42	NUM
admet-1034	94	153	2.94	2.94	NUM
admet-1034	94	154	3.31	3.31	NUM
admet-1034	94	155	trichloroethylene	trichloroethylene	NOUN
admet-1034	94	156	n	n	ADP
admet-1034	94	157	0.837	0.837	NUM
admet-1034	94	158	0.944	0.944	NUM
admet-1034	94	159	2.45	2.45	NUM
admet-1034	94	160	2.17	2.17	NUM
admet-1034	94	161	trifluoperazine	trifluoperazine	NOUN
admet-1034	94	162	bb	bb	VERB
admet-1034	94	163	3.305	3.305	NUM
admet-1034	94	164	3.651	3.651	NUM
admet-1034	94	165	5.03	5.03	NUM
admet-1034	94	166	4.87	4.87	NUM
admet-1034	94	167	4.72	4.72	NUM
admet-1034	94	168	valproic	valproic	ADJ
admet-1034	94	169	acid	acid	NOUN
admet-1034	95	1	a	a	DET
admet-1034	95	2	1.135	1.135	NUM
admet-1034	95	3	1.542	1.542	NUM
admet-1034	95	4	2.75	2.75	NUM
admet-1034	95	5	2.54	2.54	NUM
admet-1034	95	6	2.61	2.61	NUM
admet-1034	95	7	0.37	0.37	NUM
admet-1034	95	8	zidovudine	zidovudine	PROPN
admet-1034	95	9	a	a	DET
admet-1034	95	10	-0.063	-0.063	NUM
admet-1034	95	11	0.094	0.094	NUM
admet-1034	95	12	0.05	0.05	NUM
admet-1034	95	13	-0.1	-0.1	NOUN
admet-1034	95	14	-0.22	-0.22	NUM
admet-1034	95	15	-0.28	-0.28	NUM
admet-1034	95	16	figure	figure	NOUN
admet-1034	95	17	1	1	NUM
admet-1034	95	18	illustrates	illustrate	VERB
admet-1034	95	19	the	the	DET
admet-1034	95	20	relationships	relationship	NOUN
admet-1034	95	21	between	between	ADP
admet-1034	95	22	log	log	NOUN
admet-1034	95	23	bb	bb	INTJ
admet-1034	95	24	and	and	CCONJ
admet-1034	95	25	the	the	DET
admet-1034	95	26	c/’log	c/’log	PROPN
admet-1034	95	27	kw	kw	PROPN
admet-1034	95	28	iam	iam	PROPN
admet-1034	95	29	values	value	VERB
admet-1034	95	30	on	on	ADP
admet-1034	95	31	the	the	DET
admet-1034	95	32	mg	mg	PROPN
admet-1034	95	33	(	(	PUNCT
admet-1034	95	34	a	a	NOUN
admet-1034	95	35	)	)	PUNCT
admet-1034	95	36	and	and	CCONJ
admet-1034	95	37	dd2	dd2	PROPN
admet-1034	95	38	(	(	PUNCT
admet-1034	95	39	b	b	NOUN
admet-1034	95	40	)	)	PUNCT
admet-1034	95	41	stationary	stationary	ADJ
admet-1034	95	42	phases	phase	NOUN
admet-1034	95	43	and	and	CCONJ
admet-1034	95	44	a	a	DET
admet-1034	95	45	clear	clear	ADJ
admet-1034	95	46	descending	descend	VERB
admet-1034	95	47	trend	trend	NOUN
admet-1034	95	48	is	be	AUX
admet-1034	95	49	visible	visible	ADJ
admet-1034	95	50	in	in	ADP
admet-1034	95	51	both	both	DET
admet-1034	95	52	plots	plot	NOUN
admet-1034	95	53	.	.	PUNCT
admet-1034	96	1	these	these	DET
admet-1034	96	2	values	value	NOUN
admet-1034	96	3	,	,	PUNCT
admet-1034	96	4	calculated	calculate	VERB
admet-1034	96	5	by	by	ADP
admet-1034	96	6	considering	consider	VERB
admet-1034	96	7	exp	exp	NOUN
admet-1034	96	8	log	log	NOUN
admet-1034	96	9	d7.4	d7.4	NOUN
admet-1034	96	10	values	value	NOUN
admet-1034	96	11	for	for	ADP
admet-1034	96	12	acids	acid	NOUN
admet-1034	96	13	and	and	CCONJ
admet-1034	96	14	log	log	VERB
admet-1034	96	15	pn	pn	PROPN
admet-1034	96	16	values	value	NOUN
admet-1034	96	17	for	for	ADP
admet-1034	96	18	all	all	DET
admet-1034	96	19	the	the	DET
admet-1034	96	20	other	other	ADJ
admet-1034	96	21	molecules	molecule	NOUN
admet-1034	96	22	,	,	PUNCT
admet-1034	96	23	are	be	AUX
admet-1034	96	24	reported	report	VERB
admet-1034	96	25	in	in	ADP
admet-1034	96	26	table	table	NOUN
admet-1034	96	27	2	2	NUM
admet-1034	96	28	along	along	ADP
admet-1034	96	29	with	with	ADP
admet-1034	96	30	the	the	DET
admet-1034	96	31	experimental	experimental	ADJ
admet-1034	96	32	log	log	NOUN
admet-1034	96	33	bb	bb	NUM
admet-1034	96	34	values	value	NOUN
admet-1034	96	35	.	.	PUNCT
admet-1034	97	1	the	the	DET
admet-1034	97	2	dataset	dataset	NOUN
admet-1034	97	3	was	be	AUX
admet-1034	97	4	divided	divide	VERB
admet-1034	97	5	according	accord	VERB
admet-1034	97	6	to	to	ADP
admet-1034	97	7	the	the	DET
admet-1034	97	8	molecules	molecule	NOUN
admet-1034	97	9	’	'	PUNCT
admet-1034	97	10	ionization	ionization	NOUN
admet-1034	97	11	in	in	ADP
admet-1034	97	12	neutrals	neutral	NOUN
admet-1034	97	13	(	(	PUNCT
admet-1034	97	14	n	n	CCONJ
admet-1034	97	15	)	)	PUNCT
admet-1034	97	16	,	,	PUNCT
admet-1034	97	17	bases	basis	NOUN
admet-1034	97	18	supporting	support	VERB
admet-1034	97	19	one	one	NUM
admet-1034	97	20	(	(	PUNCT
admet-1034	97	21	b	b	NOUN
admet-1034	97	22	)	)	PUNCT
admet-1034	97	23	or	or	CCONJ
admet-1034	97	24	two	two	NUM
admet-1034	97	25	(	(	PUNCT
admet-1034	97	26	bb	bb	NOUN
admet-1034	97	27	)	)	PUNCT
admet-1034	97	28	basic	basic	ADJ
admet-1034	97	29	groups	group	NOUN
admet-1034	97	30	and	and	CCONJ
admet-1034	97	31	acidic	acidic	ADJ
admet-1034	97	32	(	(	PUNCT
admet-1034	97	33	a	a	PRON
admet-1034	97	34	)	)	PUNCT
admet-1034	97	35	compounds	compound	NOUN
admet-1034	97	36	.	.	PUNCT
admet-1034	98	1	this	this	PRON
admet-1034	98	2	was	be	AUX
admet-1034	98	3	set	set	VERB
admet-1034	98	4	to	to	PART
admet-1034	98	5	evaluate	evaluate	VERB
admet-1034	98	6	whether	whether	SCONJ
admet-1034	98	7	any	any	DET
admet-1034	98	8	specific	specific	ADJ
admet-1034	98	9	trend	trend	NOUN
admet-1034	98	10	was	be	AUX
admet-1034	98	11	visible	visible	ADJ
admet-1034	98	12	in	in	ADP
admet-1034	98	13	each	each	DET
admet-1034	98	14	subgroup	subgroup	NOUN
admet-1034	98	15	.	.	PUNCT
admet-1034	99	1	three	three	NUM
admet-1034	99	2	of	of	ADP
admet-1034	99	3	the	the	DET
admet-1034	99	4	assayed	assayed	ADJ
admet-1034	99	5	molecules	molecule	NOUN
admet-1034	99	6	markedly	markedly	ADV
admet-1034	99	7	deviate	deviate	VERB
admet-1034	99	8	from	from	ADP
admet-1034	99	9	the	the	DET
admet-1034	99	10	pattern	pattern	NOUN
admet-1034	99	11	identified	identify	VERB
admet-1034	99	12	by	by	ADP
admet-1034	99	13	the	the	DET
admet-1034	99	14	main	main	ADJ
admet-1034	99	15	distribution	distribution	NOUN
admet-1034	99	16	of	of	ADP
admet-1034	99	17	points	point	NOUN
admet-1034	99	18	are	be	AUX
admet-1034	99	19	triazolam	triazolam	NOUN
admet-1034	99	20	,	,	PUNCT
admet-1034	99	21	trifluoperazine	trifluoperazine	NOUN
admet-1034	99	22	and	and	CCONJ
admet-1034	99	23	valproic	valproic	ADJ
admet-1034	99	24	acid	acid	NOUN
admet-1034	99	25	.	.	PUNCT
admet-1034	100	1	the	the	DET
admet-1034	100	2	chromatographic	chromatographic	ADJ
admet-1034	100	3	behaviorur	behaviorur	NOUN
admet-1034	100	4	of	of	ADP
admet-1034	100	5	small	small	ADJ
admet-1034	100	6	molecules	molecule	NOUN
admet-1034	100	7	on	on	ADP
admet-1034	100	8	iam	iam	PROPN
admet-1034	100	9	phases	phase	NOUN
admet-1034	100	10	has	have	AUX
admet-1034	100	11	been	be	AUX
admet-1034	100	12	characterized	characterize	VERB
admet-1034	100	13	by	by	ADP
admet-1034	100	14	many	many	ADJ
admet-1034	100	15	research	research	NOUN
admet-1034	100	16	groups	group	NOUN
admet-1034	100	17	for	for	ADP
admet-1034	100	18	more	more	ADJ
admet-1034	100	19	than	than	ADP
admet-1034	100	20	three	three	NUM
admet-1034	100	21	decades	decade	NOUN
admet-1034	100	22	[	[	X
admet-1034	100	23	38,39	38,39	NOUN
admet-1034	100	24	]	]	X
admet-1034	100	25	.	.	PUNCT
admet-1034	101	1	trifluoperazine	trifluoperazine	NOUN
admet-1034	101	2	is	be	AUX
admet-1034	101	3	a	a	DET
admet-1034	101	4	highly	highly	ADV
admet-1034	101	5	lipophilic	lipophilic	ADJ
admet-1034	101	6	base	base	NOUN
admet-1034	101	7	,	,	PUNCT
admet-1034	101	8	and	and	CCONJ
admet-1034	101	9	it	it	PRON
admet-1034	101	10	is	be	AUX
admet-1034	101	11	well	well	ADV
admet-1034	101	12	ascertained	ascertain	VERB
admet-1034	101	13	[	[	X
admet-1034	101	14	14	14	NUM
admet-1034	101	15	]	]	PUNCT
admet-1034	101	16	that	that	SCONJ
admet-1034	101	17	these	these	DET
admet-1034	101	18	interact	interact	VERB
admet-1034	101	19	with	with	ADP
admet-1034	101	20	phospholipids	phospholipid	NOUN
admet-1034	101	21	weaker	weak	ADJ
admet-1034	101	22	than	than	ADP
admet-1034	101	23	isolipophilic	isolipophilic	ADJ
admet-1034	101	24	neutral	neutral	ADJ
admet-1034	101	25	compounds	compound	NOUN
admet-1034	101	26	,	,	PUNCT
admet-1034	101	27	especially	especially	ADV
admet-1034	101	28	on	on	ADP
admet-1034	101	29	the	the	DET
admet-1034	101	30	iam.pc.dd2	iam.pc.dd2	PROPN
admet-1034	101	31	phase	phase	NOUN
admet-1034	101	32	.	.	PUNCT
admet-1034	102	1	as	as	ADP
admet-1034	102	2	to	to	ADP
admet-1034	102	3	triazolam	triazolam	NOUN
admet-1034	102	4	and	and	CCONJ
admet-1034	102	5	valproic	valproic	ADJ
admet-1034	102	6	acid	acid	NOUN
admet-1034	102	7	,	,	PUNCT
admet-1034	102	8	the	the	DET
admet-1034	102	9	reasons	reason	NOUN
admet-1034	102	10	for	for	ADP
admet-1034	102	11	these	these	DET
admet-1034	102	12	deviating	deviating	NOUN
admet-1034	102	13	from	from	ADP
admet-1034	102	14	the	the	DET
admet-1034	102	15	main	main	ADJ
admet-1034	102	16	distribution	distribution	NOUN
admet-1034	102	17	of	of	ADP
admet-1034	102	18	points	point	NOUN
admet-1034	102	19	do	do	AUX
admet-1034	102	20	not	not	PART
admet-1034	102	21	seem	seem	VERB
admet-1034	102	22	that	that	DET
admet-1034	102	23	straightforward	straightforward	ADJ
admet-1034	102	24	to	to	PART
admet-1034	102	25	spot	spot	VERB
admet-1034	102	26	.	.	PUNCT
admet-1034	103	1	triazolam	triazolam	PROPN
admet-1034	103	2	is	be	AUX
admet-1034	103	3	a	a	DET
admet-1034	103	4	benzodiazepine	benzodiazepine	NOUN
admet-1034	103	5	derivative	derivative	NOUN
admet-1034	103	6	featuring	feature	VERB
admet-1034	103	7	a	a	DET
admet-1034	103	8	structure	structure	NOUN
admet-1034	103	9	of	of	ADP
admet-1034	103	10	three	three	NUM
admet-1034	103	11	condensed	condense	VERB
admet-1034	103	12	rings	ring	NOUN
admet-1034	103	13	covalently	covalently	ADV
admet-1034	103	14	bound	bind	VERB
admet-1034	103	15	to	to	ADP
admet-1034	103	16	one	one	NUM
admet-1034	103	17	chlorobenzene	chlorobenzene	NOUN
admet-1034	103	18	moiety	moiety	NOUN
admet-1034	103	19	sharing	share	VERB
admet-1034	103	20	the	the	DET
admet-1034	103	21	same	same	ADJ
admet-1034	103	22	plane	plane	NOUN
admet-1034	103	23	.	.	PUNCT
admet-1034	104	1	it	it	PRON
admet-1034	104	2	has	have	AUX
admet-1034	104	3	been	be	AUX
admet-1034	104	4	again	again	ADV
admet-1034	104	5	already	already	ADV
admet-1034	104	6	characterized	characterize	VERB
admet-1034	104	7	[	[	X
admet-1034	104	8	39	39	NUM
admet-1034	104	9	]	]	PUNCT
admet-1034	104	10	that	that	SCONJ
admet-1034	104	11	those	those	DET
admet-1034	104	12	planar	planar	ADJ
admet-1034	104	13	structures	structure	NOUN
admet-1034	104	14	tend	tend	VERB
admet-1034	104	15	to	to	PART
admet-1034	104	16	interact	interact	VERB
admet-1034	104	17	with	with	ADP
admet-1034	104	18	iam	iam	PROPN
admet-1034	104	19	phases	phase	NOUN
admet-1034	104	20	stronger	strong	ADJ
admet-1034	104	21	than	than	ADP
admet-1034	104	22	the	the	DET
admet-1034	104	23	extent	extent	NOUN
admet-1034	104	24	expected	expect	VERB
admet-1034	104	25	based	base	VERB
admet-1034	104	26	on	on	ADP
admet-1034	104	27	their	their	PRON
admet-1034	104	28	lipophilicity	lipophilicity	NOUN
admet-1034	104	29	,	,	PUNCT
admet-1034	104	30	but	but	CCONJ
admet-1034	104	31	it	it	PRON
admet-1034	104	32	is	be	AUX
admet-1034	104	33	hard	hard	ADJ
admet-1034	104	34	to	to	PART
admet-1034	104	35	assess	assess	VERB
admet-1034	104	36	whether	whether	SCONJ
admet-1034	104	37	this	this	PRON
admet-1034	104	38	played	play	VERB
admet-1034	104	39	a	a	DET
admet-1034	104	40	role	role	NOUN
admet-1034	104	41	in	in	ADP
admet-1034	104	42	this	this	DET
admet-1034	104	43	instance	instance	NOUN
admet-1034	104	44	.	.	PUNCT
admet-1034	105	1	for	for	ADP
admet-1034	105	2	its	its	PRON
admet-1034	105	3	being	be	AUX
admet-1034	105	4	an	an	DET
admet-1034	105	5	acid	acid	NOUN
admet-1034	105	6	,	,	PUNCT
admet-1034	105	7	the	the	DET
admet-1034	105	8	calculation	calculation	NOUN
admet-1034	105	9	of	of	ADP
admet-1034	105	10	cδ’log	cδ’log	PROPN
admet-1034	105	11	kw	kw	PROPN
admet-1034	105	12	iam	iam	PROPN
admet-1034	105	13	of	of	ADP
admet-1034	105	14	valproic	valproic	ADJ
admet-1034	105	15	acid	acid	NOUN
admet-1034	105	16	was	be	AUX
admet-1034	105	17	based	base	VERB
admet-1034	105	18	on	on	ADP
admet-1034	105	19	log	log	NOUN
admet-1034	105	20	d7.4	d7.4	NUM
admet-1034	105	21	rather	rather	ADV
admet-1034	105	22	than	than	ADP
admet-1034	105	23	log	log	VERB
admet-1034	105	24	pn	pn	PROPN
admet-1034	105	25	.	.	PUNCT
admet-1034	106	1	however	however	ADV
admet-1034	106	2	,	,	PUNCT
admet-1034	106	3	since	since	SCONJ
admet-1034	106	4	we	we	PRON
admet-1034	106	5	could	could	AUX
admet-1034	106	6	not	not	PART
admet-1034	106	7	retrieve	retrieve	VERB
admet-1034	106	8	the	the	DET
admet-1034	106	9	admet	admet	PROPN
admet-1034	106	10	&	&	CCONJ
admet-1034	106	11	dmpk	dmpk	PROPN
admet-1034	106	12	9(4	9(4	PROPN
admet-1034	106	13	)	)	PUNCT
admet-1034	106	14	(	(	PUNCT
admet-1034	106	15	2021	2021	NUM
admet-1034	106	16	)	)	PUNCT
admet-1034	106	17	267	267	NUM
admet-1034	106	18	-	-	SYM
admet-1034	106	19	281	281	NUM
admet-1034	106	20	bbb	bbb	PROPN
admet-1034	106	21	passage	passage	NOUN
admet-1034	106	22	based	base	VERB
admet-1034	106	23	on	on	ADP
admet-1034	106	24	in	in	ADP
admet-1034	106	25	silico	silico	NOUN
admet-1034	106	26	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	106	27	doi	doi	NOUN
admet-1034	106	28	:	:	PUNCT
admet-1034	106	29	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	106	30	273	273	NUM
admet-1034	106	31	experimental	experimental	ADJ
admet-1034	106	32	value	value	NOUN
admet-1034	106	33	from	from	ADP
admet-1034	106	34	literature	literature	NOUN
admet-1034	106	35	sources	source	NOUN
admet-1034	106	36	,	,	PUNCT
admet-1034	106	37	we	we	PRON
admet-1034	106	38	had	have	VERB
admet-1034	106	39	to	to	PART
admet-1034	106	40	rely	rely	VERB
admet-1034	106	41	on	on	ADP
admet-1034	106	42	the	the	DET
admet-1034	106	43	calculated	calculate	VERB
admet-1034	106	44	value	value	NOUN
admet-1034	106	45	,	,	PUNCT
admet-1034	106	46	whose	whose	DET
admet-1034	106	47	closeness	closeness	NOUN
admet-1034	106	48	to	to	ADP
admet-1034	106	49	the	the	DET
admet-1034	106	50	actual	actual	ADJ
admet-1034	106	51	value	value	NOUN
admet-1034	106	52	can	can	AUX
admet-1034	106	53	not	not	PART
admet-1034	106	54	be	be	AUX
admet-1034	106	55	reasonably	reasonably	ADV
admet-1034	106	56	taken	take	VERB
admet-1034	106	57	for	for	ADP
admet-1034	106	58	granted	grant	VERB
admet-1034	106	59	.	.	PUNCT
admet-1034	107	1	interestingly	interestingly	ADV
admet-1034	107	2	,	,	PUNCT
admet-1034	107	3	a	a	DET
admet-1034	107	4	descending	descend	VERB
admet-1034	107	5	trend	trend	NOUN
admet-1034	107	6	is	be	AUX
admet-1034	107	7	visible	visible	ADJ
admet-1034	107	8	for	for	ADP
admet-1034	107	9	neutral	neutral	ADJ
admet-1034	107	10	compounds	compound	NOUN
admet-1034	107	11	between	between	ADP
admet-1034	107	12	the	the	DET
admet-1034	107	13	c/’log	c/’log	PROPN
admet-1034	107	14	kw	kw	PROPN
admet-1034	107	15	iam	iam	PROPN
admet-1034	107	16	and	and	CCONJ
admet-1034	107	17	log	log	VERB
admet-1034	107	18	bb	bb	NOUN
admet-1034	107	19	values	value	NOUN
admet-1034	107	20	ranging	range	VERB
admet-1034	107	21	from	from	ADP
admet-1034	107	22	+1	+1	PROPN
admet-1034	107	23	to	to	ADP
admet-1034	107	24	0	0	NUM
admet-1034	108	1	but	but	CCONJ
admet-1034	108	2	the	the	DET
admet-1034	108	3	distribution	distribution	NOUN
admet-1034	108	4	flattens	flatten	VERB
admet-1034	108	5	for	for	ADP
admet-1034	108	6	log	log	NOUN
admet-1034	108	7	bb	bb	INTJ
admet-1034	108	8	<	<	X
admet-1034	108	9	0	0	X
admet-1034	108	10	.	.	PUNCT
admet-1034	108	11	figure	figure	NOUN
admet-1034	108	12	1	1	NUM
admet-1034	108	13	.	.	PUNCT
admet-1034	109	1	relationships	relationship	NOUN
admet-1034	109	2	between	between	ADP
admet-1034	109	3	log	log	NOUN
admet-1034	109	4	bb	bb	NUM
admet-1034	109	5	values	value	NOUN
admet-1034	109	6	and	and	CCONJ
admet-1034	109	7	c/’log	c/’log	NOUN
admet-1034	109	8	kw	kw	PROPN
admet-1034	109	9	iam.mg	iam.mg	PROPN
admet-1034	109	10	(	(	PUNCT
admet-1034	109	11	a	a	NOUN
admet-1034	109	12	)	)	PUNCT
admet-1034	109	13	and	and	CCONJ
admet-1034	109	14	c/’log	c/’log	NOUN
admet-1034	109	15	kw	kw	PROPN
admet-1034	109	16	iam.dd2	iam.dd2	NOUN
admet-1034	109	17	values	value	NOUN
admet-1034	109	18	(	(	PUNCT
admet-1034	109	19	b	b	NOUN
admet-1034	109	20	)	)	PUNCT
admet-1034	109	21	.	.	PUNCT
admet-1034	110	1	table	table	NOUN
admet-1034	110	2	2	2	NUM
admet-1034	110	3	.	.	PUNCT
admet-1034	110	4	c/’log	c/’log	PROPN
admet-1034	110	5	kw	kw	PROPN
admet-1034	110	6	iam.mg	iam.mg	PROPN
admet-1034	110	7	,	,	PUNCT
admet-1034	110	8	c/’log	c/’log	NOUN
admet-1034	110	9	kw	kw	INTJ
admet-1034	110	10	iam.dd2	iam.dd2	NOUN
admet-1034	110	11	values	value	NOUN
admet-1034	110	12	and	and	CCONJ
admet-1034	110	13	experimental	experimental	ADJ
admet-1034	110	14	log	log	NOUN
admet-1034	110	15	bb	bb	NUM
admet-1034	110	16	values	value	NOUN
admet-1034	110	17	for	for	ADP
admet-1034	110	18	the	the	DET
admet-1034	110	19	dataset	dataset	NOUN
admet-1034	110	20	considered	consider	VERB
admet-1034	110	21	.	.	PUNCT
admet-1034	111	1	molecule	molecule	NOUN
admet-1034	111	2	cδ	cδ	NOUN
admet-1034	111	3	/	/	SYM
admet-1034	111	4	δ’log	δ’log	NOUN
admet-1034	111	5	kw	kw	PROPN
admet-1034	111	6	iam.mg	iam.mg	PROPN
admet-1034	111	7	cδ	cδ	NOUN
admet-1034	111	8	/	/	SYM
admet-1034	111	9	δ’log	δ’log	NOUN
admet-1034	111	10	kw	kw	INTJ
admet-1034	111	11	iam.dd2	iam.dd2	NOUN
admet-1034	111	12	log	log	VERB
admet-1034	112	1	bb	bb	NOUN
admet-1034	112	2	1,1,1	1,1,1	NUM
admet-1034	112	3	-	-	PUNCT
admet-1034	112	4	trichloroethane	trichloroethane	NOUN
admet-1034	112	5	-0.177	-0.177	SYM
admet-1034	112	6	-0.196	-0.196	NOUN
admet-1034	112	7	0.40	0.40	NUM
admet-1034	112	8	1,2	1,2	NUM
admet-1034	112	9	-	-	PUNCT
admet-1034	112	10	dimethylbenzene	dimethylbenzene	NOUN
admet-1034	112	11	-0.339	-0.339	NOUN
admet-1034	112	12	-0.396	-0.396	ADV
admet-1034	112	13	0.37	0.37	NUM
admet-1034	112	14	1,4	1,4	NUM
admet-1034	112	15	-	-	PUNCT
admet-1034	112	16	dimethylbenzene	dimethylbenzene	NOUN
admet-1034	112	17	-0.342	-0.342	NOUN
admet-1034	112	18	-0.460	-0.460	PUNCT
admet-1034	112	19	0.31	0.31	NUM
admet-1034	112	20	1,7	1,7	NUM
admet-1034	112	21	-	-	PUNCT
admet-1034	112	22	dimethylxanthine	dimethylxanthine	VERB
admet-1034	112	23	0.588	0.588	NUM
admet-1034	112	24	0.798	0.798	NUM
admet-1034	112	25	0.06	0.06	NUM
admet-1034	112	26	1	1	NUM
admet-1034	112	27	-	-	PUNCT
admet-1034	112	28	chloro-2,2,2	chloro-2,2,2	NOUN
admet-1034	112	29	-	-	PUNCT
admet-1034	112	30	trifluoroethane	trifluoroethane	NOUN
admet-1034	112	31	0.070	0.070	NUM
admet-1034	112	32	-0.080	-0.080	NOUN
admet-1034	112	33	0.08	0.08	NUM
admet-1034	112	34	1	1	NUM
admet-1034	112	35	-	-	NUM
admet-1034	112	36	hydroxymidazolam	hydroxymidazolam	NOUN
admet-1034	112	37	0.274	0.274	NUM
admet-1034	112	38	0.217	0.217	NUM
admet-1034	112	39	-0.07	-0.07	NUM
admet-1034	112	40	2,2	2,2	NUM
admet-1034	112	41	-	-	PROPN
admet-1034	112	42	dimethylbutane	dimethylbutane	NOUN
admet-1034	112	43	-1.010	-1.010	NOUN
admet-1034	112	44	-1.107	-1.107	PUNCT
admet-1034	112	45	1.04	1.04	NUM
admet-1034	112	46	2	2	NUM
admet-1034	112	47	-	-	PUNCT
admet-1034	112	48	methylpentane	methylpentane	NOUN
admet-1034	112	49	-0.422	-0.422	NOUN
admet-1034	112	50	-0.409	-0.409	NUM
admet-1034	112	51	0.97	0.97	NUM
admet-1034	112	52	3	3	NUM
admet-1034	112	53	-	-	PUNCT
admet-1034	112	54	methylhexane	methylhexane	NOUN
admet-1034	112	55	-0.249	-0.249	PUNCT
admet-1034	112	56	-0.166	-0.166	PUNCT
admet-1034	112	57	0.90	0.90	NUM
admet-1034	112	58	3	3	NUM
admet-1034	112	59	-	-	PUNCT
admet-1034	112	60	methylpentane	methylpentane	NOUN
admet-1034	112	61	-0.827	-0.827	NOUN
admet-1034	112	62	-0.880	-0.880	NUM
admet-1034	112	63	1.01	1.01	NUM
admet-1034	112	64	4	4	NUM
admet-1034	112	65	-	-	SYM
admet-1034	112	66	hydroxymidazolam	hydroxymidazolam	NOUN
admet-1034	112	67	0.029	0.029	NUM
admet-1034	112	68	-0.055	-0.055	PUNCT
admet-1034	112	69	-0.30	-0.30	PUNCT
admet-1034	112	70	acetaminophen	acetaminophen	NOUN
admet-1034	112	71	0.195	0.195	NUM
admet-1034	112	72	0.335	0.335	NUM
admet-1034	112	73	-0.31	-0.31	NUM
admet-1034	112	74	acetone	acetone	NOUN
admet-1034	112	75	0.675	0.675	NUM
admet-1034	112	76	0.748	0.748	NUM
admet-1034	112	77	-0.15	-0.15	NUM
admet-1034	112	78	aminopyrine	aminopyrine	NOUN
admet-1034	112	79	0.985	0.985	NUM
admet-1034	112	80	1.298	1.298	NUM
admet-1034	112	81	0.00	0.00	NUM
admet-1034	112	82	amobarbital	amobarbital	ADJ
admet-1034	112	83	0.364	0.364	NUM
admet-1034	112	84	0.570	0.570	NUM
admet-1034	112	85	0.04	0.04	NUM
admet-1034	112	86	antipyrine	antipyrine	NOUN
admet-1034	112	87	1.189	1.189	NUM
admet-1034	112	88	1.499	1.499	NUM
admet-1034	112	89	-0.10	-0.10	NUM
admet-1034	112	90	bretazenil	bretazenil	NOUN
admet-1034	112	91	1.021	1.021	NUM
admet-1034	112	92	1.191	1.191	NUM
admet-1034	113	1	-0.09	-0.09	NUM
admet-1034	113	2	cyclohexane	cyclohexane	NOUN
admet-1034	113	3	-0.516	-0.516	PUNCT
admet-1034	113	4	-0.659	-0.659	NOUN
admet-1034	113	5	0.92	0.92	NUM
admet-1034	113	6	cyclopropane	cyclopropane	NOUN
admet-1034	113	7	-0.346	-0.346	PUNCT
admet-1034	113	8	-0.618	-0.618	PUNCT
admet-1034	113	9	0.00	0.00	NUM
admet-1034	113	10	desmonomethylpromazine	desmonomethylpromazine	NOUN
admet-1034	113	11	0.104	0.104	NUM
admet-1034	113	12	0.149	0.149	NUM
admet-1034	113	13	0.59	0.59	NUM
admet-1034	113	14	didanosine	didanosine	VERB
admet-1034	113	15	1.168	1.168	NUM
admet-1034	113	16	1.579	1.579	NUM
admet-1034	113	17	-1.30	-1.30	ADJ
admet-1034	113	18	diethylene	diethylene	NOUN
admet-1034	113	19	glycol	glycol	NOUN
admet-1034	113	20	divinyl	divinyl	NOUN
admet-1034	113	21	ether	ether	NOUN
admet-1034	113	22	-0.084	-0.084	PUNCT
admet-1034	113	23	0.270	0.270	NUM
admet-1034	113	24	0.11	0.11	NUM
admet-1034	113	25	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	113	26	grumetto	grumetto	NOUN
admet-1034	113	27	and	and	CCONJ
admet-1034	113	28	russo	russo	PROPN
admet-1034	113	29	admet	admet	PROPN
admet-1034	113	30	&	&	CCONJ
admet-1034	113	31	dmpk	dmpk	PROPN
admet-1034	113	32	9(4	9(4	PROPN
admet-1034	113	33	)	)	PUNCT
admet-1034	113	34	(	(	PUNCT
admet-1034	113	35	2021	2021	NUM
admet-1034	113	36	)	)	PUNCT
admet-1034	113	37	267	267	NUM
admet-1034	113	38	-	-	SYM
admet-1034	113	39	281	281	NUM
admet-1034	113	40	274	274	NUM
admet-1034	113	41	table	table	NOUN
admet-1034	113	42	2	2	NUM
admet-1034	113	43	.	.	NUM
admet-1034	113	44	continued	continue	VERB
admet-1034	113	45	…	…	PUNCT
admet-1034	113	46	molecule	molecule	NOUN
admet-1034	113	47	cδ	cδ	NOUN
admet-1034	113	48	/	/	SYM
admet-1034	113	49	δ’log	δ’log	NOUN
admet-1034	113	50	kw	kw	PROPN
admet-1034	113	51	iam.mg	iam.mg	PROPN
admet-1034	113	52	cδ	cδ	NOUN
admet-1034	113	53	/	/	SYM
admet-1034	113	54	δ’log	δ’log	NOUN
admet-1034	113	55	kw	kw	INTJ
admet-1034	113	56	iam.dd2	iam.dd2	NOUN
admet-1034	113	57	log	log	NOUN
admet-1034	113	58	bb	bb	NOUN
admet-1034	113	59	enflurane	enflurane	NOUN
admet-1034	113	60	0.144	0.144	NUM
admet-1034	113	61	0.125	0.125	NUM
admet-1034	113	62	0.24	0.24	NUM
admet-1034	113	63	ethanol	ethanol	NOUN
admet-1034	113	64	0.444	0.444	NUM
admet-1034	113	65	0.490	0.490	NUM
admet-1034	113	66	-0.16	-0.16	PROPN
admet-1034	113	67	ethyl	ethyl	PROPN
admet-1034	113	68	ether	ether	NOUN
admet-1034	113	69	0.189	0.189	NUM
admet-1034	113	70	0.360	0.360	NUM
admet-1034	113	71	0.00	0.00	NUM
admet-1034	113	72	ethylbenzene	ethylbenzene	NOUN
admet-1034	113	73	-0.365	-0.365	PUNCT
admet-1034	113	74	-0.443	-0.443	NOUN
admet-1034	113	75	0.20	0.20	NUM
admet-1034	113	76	flunitrazepam	flunitrazepam	NOUN
admet-1034	113	77	0.721	0.721	NUM
admet-1034	113	78	0.698	0.698	NUM
admet-1034	113	79	0.06	0.06	NUM
admet-1034	113	80	fluroxene	fluroxene	NOUN
admet-1034	113	81	0.051	0.051	NUM
admet-1034	113	82	0.044	0.044	NUM
admet-1034	113	83	0.13	0.13	NUM
admet-1034	113	84	halothane	halothane	NOUN
admet-1034	113	85	0.075	0.075	NUM
admet-1034	113	86	0.035	0.035	NUM
admet-1034	113	87	0.35	0.35	NUM
admet-1034	113	88	indinavir	indinavir	NOUN
admet-1034	113	89	1.299	1.299	NUM
admet-1034	113	90	0.919	0.919	NUM
admet-1034	113	91	-0.74	-0.74	PROPN
admet-1034	113	92	isobutyl	isobutyl	NOUN
admet-1034	113	93	alcohol	alcohol	NOUN
admet-1034	113	94	0.175	0.175	NUM
admet-1034	113	95	0.342	0.342	NUM
admet-1034	113	96	-0.17	-0.17	PROPN
admet-1034	113	97	isoflurane	isoflurane	NOUN
admet-1034	113	98	0.174	0.174	NUM
admet-1034	113	99	0.166	0.166	NUM
admet-1034	113	100	0.42	0.42	NUM
admet-1034	113	101	isopropyl	isopropyl	NOUN
admet-1034	113	102	alcohol	alcohol	NOUN
admet-1034	113	103	0.451	0.451	NUM
admet-1034	113	104	0.593	0.593	NUM
admet-1034	113	105	-0.15	-0.15	NUM
admet-1034	113	106	mesoridazine	mesoridazine	NOUN
admet-1034	113	107	0.283	0.283	NUM
admet-1034	113	108	0.267	0.267	NUM
admet-1034	113	109	-0.36	-0.36	NUM
admet-1034	113	110	methoxyflurane	methoxyflurane	NOUN
admet-1034	113	111	-0.154	-0.154	X
admet-1034	113	112	-0.111	-0.111	X
admet-1034	113	113	0.25	0.25	NUM
admet-1034	113	114	methyl	methyl	NOUN
admet-1034	113	115	cyclopentane	cyclopentane	NOUN
admet-1034	113	116	-0.797	-0.797	PUNCT
admet-1034	113	117	-0.918	-0.918	PROPN
admet-1034	113	118	0.93	0.93	NUM
admet-1034	113	119	methyl	methyl	NOUN
admet-1034	113	120	ethyl	ethyl	PROPN
admet-1034	113	121	ketone	ketone	NOUN
admet-1034	113	122	0.549	0.549	NUM
admet-1034	113	123	0.669	0.669	NUM
admet-1034	113	124	-0.08	-0.08	NUM
admet-1034	113	125	mirtazapine	mirtazapine	NOUN
admet-1034	113	126	0.404	0.404	NUM
admet-1034	113	127	0.461	0.461	NUM
admet-1034	113	128	0.53	0.53	NUM
admet-1034	113	129	m	m	NUM
admet-1034	113	130	-	-	PUNCT
admet-1034	113	131	xylene	xylene	NOUN
admet-1034	113	132	-0.392	-0.392	X
admet-1034	113	133	-0.465	-0.465	PUNCT
admet-1034	113	134	0.29	0.29	NUM
admet-1034	113	135	nevirapine	nevirapine	ADJ
admet-1034	113	136	-0.096	-0.096	PUNCT
admet-1034	113	137	-0.120	-0.120	PUNCT
admet-1034	113	138	0.00	0.00	NUM
admet-1034	113	139	n	n	CCONJ
admet-1034	113	140	-	-	PUNCT
admet-1034	113	141	heptane	heptane	NOUN
admet-1034	113	142	-0.075	-0.075	NOUN
admet-1034	113	143	0.008	0.008	NUM
admet-1034	113	144	0.81	0.81	NUM
admet-1034	113	145	n	n	CCONJ
admet-1034	113	146	-	-	PUNCT
admet-1034	113	147	hexane	hexane	NOUN
admet-1034	113	148	-0.004	-0.004	NUM
admet-1034	113	149	0.054	0.054	NUM
admet-1034	113	150	0.80	0.80	NUM
admet-1034	113	151	nordazepam	nordazepam	NOUN
admet-1034	113	152	0.004	0.004	NUM
admet-1034	113	153	-0.088	-0.088	NUM
admet-1034	113	154	0.50	0.50	NUM
admet-1034	113	155	northioridazine	northioridazine	NOUN
admet-1034	113	156	-0.187	-0.187	PROPN
admet-1034	113	157	-0.273	-0.273	PROPN
admet-1034	113	158	0.75	0.75	NUM
admet-1034	113	159	n	n	CCONJ
admet-1034	113	160	-	-	PUNCT
admet-1034	113	161	pentane	pentane	NOUN
admet-1034	113	162	0.059	0.059	NUM
admet-1034	113	163	0.086	0.086	NUM
admet-1034	113	164	0.76	0.76	NUM
admet-1034	113	165	quinidine	quinidine	PROPN
admet-1034	113	166	0.024	0.024	NUM
admet-1034	113	167	0.064	0.064	NUM
admet-1034	113	168	-0.46	-0.46	NUM
admet-1034	113	169	sulforidazine	sulforidazine	PROPN
admet-1034	113	170	-0.108	-0.108	PUNCT
admet-1034	113	171	-0.216	-0.216	PUNCT
admet-1034	113	172	0.18	0.18	NUM
admet-1034	113	173	teflurane	teflurane	NOUN
admet-1034	113	174	0.470	0.470	NUM
admet-1034	113	175	0.427	0.427	NUM
admet-1034	113	176	0.27	0.27	NUM
admet-1034	113	177	thioridazine	thioridazine	NOUN
admet-1034	113	178	-0.623	-0.623	ADP
admet-1034	113	179	-0.812	-0.812	NOUN
admet-1034	113	180	0.24	0.24	NUM
admet-1034	113	181	thioxolone	thioxolone	NOUN
admet-1034	113	182	0.057	0.057	NUM
admet-1034	113	183	0.074	0.074	NUM
admet-1034	113	184	0.40	0.40	NUM
admet-1034	113	185	tiotidine	tiotidine	NOUN
admet-1034	113	186	0.379	0.379	NUM
admet-1034	113	187	0.623	0.623	NUM
admet-1034	113	188	-0.82	-0.82	X
admet-1034	113	189	triazolam	triazolam	NOUN
admet-1034	113	190	0.917	0.917	NUM
admet-1034	113	191	0.988	0.988	NUM
admet-1034	113	192	0.74	0.74	NUM
admet-1034	113	193	trichloroethylene	trichloroethylene	NOUN
admet-1034	113	194	-0.150	-0.150	NOUN
admet-1034	113	195	-0.200	-0.200	PUNCT
admet-1034	113	196	0.34	0.34	NUM
admet-1034	113	197	trifluoperazine	trifluoperazine	NOUN
admet-1034	113	198	0.053	0.053	NUM
admet-1034	113	199	-0.164	-0.164	NOUN
admet-1034	113	200	1.44	1.44	NUM
admet-1034	113	201	valproic	valproic	ADJ
admet-1034	113	202	acid	acid	NOUN
admet-1034	113	203	1.574	1.574	NUM
admet-1034	113	204	2.079	2.079	NUM
admet-1034	113	205	-0.22	-0.22	NUM
admet-1034	113	206	zidovudine	zidovudine	PROPN
admet-1034	113	207	0.891	0.891	NUM
admet-1034	113	208	1.239	1.239	NUM
admet-1034	113	209	-0.72	-0.72	NUM
admet-1034	113	210	figure	figure	NOUN
admet-1034	113	211	2	2	NUM
admet-1034	113	212	instead	instead	ADV
admet-1034	113	213	displays	display	VERB
admet-1034	113	214	the	the	DET
admet-1034	113	215	relationship	relationship	NOUN
admet-1034	113	216	occurring	occur	VERB
admet-1034	113	217	between	between	ADP
admet-1034	113	218	the	the	DET
admet-1034	113	219	data	datum	NOUN
admet-1034	113	220	of	of	ADP
admet-1034	113	221	permeation	permeation	NOUN
admet-1034	113	222	through	through	ADP
admet-1034	113	223	the	the	DET
admet-1034	113	224	bbb	bbb	NOUN
admet-1034	113	225	and	and	CCONJ
admet-1034	113	226	experimental	experimental	ADJ
admet-1034	113	227	n	n	CCONJ
admet-1034	113	228	-	-	PUNCT
admet-1034	113	229	octanol	octanol	NOUN
admet-1034	113	230	/	/	SYM
admet-1034	113	231	water	water	NOUN
admet-1034	113	232	lipophilicity	lipophilicity	NOUN
admet-1034	113	233	values	value	NOUN
admet-1034	113	234	.	.	PUNCT
admet-1034	114	1	the	the	DET
admet-1034	114	2	experimental	experimental	ADJ
admet-1034	114	3	log	log	NOUN
admet-1034	114	4	p	p	NOUN
admet-1034	114	5	values	value	NOUN
admet-1034	114	6	for	for	ADP
admet-1034	114	7	1	1	NUM
admet-1034	114	8	-	-	PUNCT
admet-1034	114	9	chloro-2,2,2trifluoroethane	chloro-2,2,2trifluoroethane	NOUN
admet-1034	114	10	,	,	PUNCT
admet-1034	114	11	1	1	NUM
admet-1034	114	12	-	-	PUNCT
admet-1034	114	13	hydroxymidazolam	hydroxymidazolam	NOUN
admet-1034	114	14	,	,	PUNCT
admet-1034	114	15	3	3	NUM
admet-1034	114	16	-	-	PUNCT
admet-1034	114	17	methylhexane	methylhexane	NOUN
admet-1034	114	18	,	,	PUNCT
admet-1034	114	19	4	4	NUM
admet-1034	114	20	-	-	SYM
admet-1034	114	21	hydroxymidazolam	hydroxymidazolam	PROPN
admet-1034	114	22	,	,	PUNCT
admet-1034	114	23	bretazenil	bretazenil	NOUN
admet-1034	114	24	,	,	PUNCT
admet-1034	114	25	desmonomethylpromazine	desmonomethylpromazine	NOUN
admet-1034	114	26	,	,	PUNCT
admet-1034	114	27	fluroxene	fluroxene	NOUN
admet-1034	114	28	,	,	PUNCT
admet-1034	114	29	isoflurane	isoflurane	NOUN
admet-1034	114	30	,	,	PUNCT
admet-1034	114	31	n	n	CCONJ
admet-1034	114	32	-	-	PUNCT
admet-1034	114	33	heptane	heptane	NOUN
admet-1034	114	34	,	,	PUNCT
admet-1034	114	35	n	n	CCONJ
admet-1034	114	36	-	-	PUNCT
admet-1034	114	37	hexane	hexane	NOUN
admet-1034	114	38	,	,	PUNCT
admet-1034	114	39	nordiazepam	nordiazepam	NOUN
admet-1034	114	40	,	,	PUNCT
admet-1034	114	41	northioridazine	northioridazine	NOUN
admet-1034	114	42	,	,	PUNCT
admet-1034	114	43	n	n	CCONJ
admet-1034	114	44	-	-	PUNCT
admet-1034	114	45	pentane	pentane	NOUN
admet-1034	114	46	,	,	PUNCT
admet-1034	114	47	teflurane	teflurane	NOUN
admet-1034	114	48	and	and	CCONJ
admet-1034	114	49	trichloroethylene	trichloroethylene	NOUN
admet-1034	114	50	were	be	AUX
admet-1034	114	51	not	not	PART
admet-1034	114	52	available	available	ADJ
admet-1034	114	53	and	and	CCONJ
admet-1034	114	54	,	,	PUNCT
admet-1034	114	55	therefore	therefore	ADV
admet-1034	114	56	,	,	PUNCT
admet-1034	114	57	calculated	calculate	VERB
admet-1034	114	58	values	value	NOUN
admet-1034	114	59	were	be	AUX
admet-1034	114	60	used	use	VERB
admet-1034	114	61	instead	instead	ADV
admet-1034	114	62	.	.	PUNCT
admet-1034	115	1	clearly	clearly	ADV
admet-1034	115	2	,	,	PUNCT
admet-1034	115	3	log	log	PROPN
admet-1034	115	4	p	p	NOUN
admet-1034	115	5	represents	represent	VERB
admet-1034	115	6	an	an	DET
admet-1034	115	7	index	index	NOUN
admet-1034	115	8	of	of	ADP
admet-1034	115	9	paramount	paramount	ADJ
admet-1034	115	10	importance	importance	NOUN
admet-1034	115	11	in	in	ADP
admet-1034	115	12	pharmaceutical	pharmaceutical	ADJ
admet-1034	115	13	discovery	discovery	NOUN
admet-1034	115	14	and	and	CCONJ
admet-1034	115	15	development	development	NOUN
admet-1034	115	16	[	[	X
admet-1034	115	17	40	40	NUM
admet-1034	115	18	]	]	PUNCT
admet-1034	115	19	.	.	PUNCT
admet-1034	116	1	the	the	DET
admet-1034	116	2	assumption	assumption	NOUN
admet-1034	116	3	is	be	AUX
admet-1034	116	4	that	that	SCONJ
admet-1034	116	5	lead	lead	NOUN
admet-1034	116	6	compounds	compound	NOUN
admet-1034	116	7	should	should	AUX
admet-1034	116	8	lie	lie	VERB
admet-1034	116	9	in	in	ADP
admet-1034	116	10	a	a	DET
admet-1034	116	11	specific	specific	ADJ
admet-1034	116	12	range	range	NOUN
admet-1034	116	13	of	of	ADP
admet-1034	116	14	lipophilicity	lipophilicity	NOUN
admet-1034	116	15	to	to	PART
admet-1034	116	16	be	be	AUX
admet-1034	116	17	considered	consider	VERB
admet-1034	116	18	for	for	ADP
admet-1034	116	19	further	further	ADJ
admet-1034	116	20	admet	admet	PROPN
admet-1034	116	21	&	&	CCONJ
admet-1034	116	22	dmpk	dmpk	PROPN
admet-1034	116	23	9(4	9(4	PROPN
admet-1034	116	24	)	)	PUNCT
admet-1034	116	25	(	(	PUNCT
admet-1034	116	26	2021	2021	NUM
admet-1034	116	27	)	)	PUNCT
admet-1034	116	28	267	267	NUM
admet-1034	116	29	-	-	SYM
admet-1034	116	30	281	281	NUM
admet-1034	116	31	bbb	bbb	PROPN
admet-1034	116	32	passage	passage	NOUN
admet-1034	116	33	based	base	VERB
admet-1034	116	34	on	on	ADP
admet-1034	116	35	in	in	ADP
admet-1034	116	36	silico	silico	NOUN
admet-1034	116	37	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	116	38	doi	doi	NOUN
admet-1034	116	39	:	:	PUNCT
admet-1034	116	40	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	116	41	275	275	NUM
admet-1034	116	42	implementations	implementation	NOUN
admet-1034	116	43	.	.	PUNCT
admet-1034	117	1	the	the	DET
admet-1034	117	2	expectation	expectation	NOUN
admet-1034	117	3	is	be	AUX
admet-1034	117	4	that	that	SCONJ
admet-1034	117	5	lipophilicity	lipophilicity	NOUN
admet-1034	117	6	should	should	AUX
admet-1034	117	7	be	be	AUX
admet-1034	117	8	positively	positively	ADV
admet-1034	117	9	related	relate	VERB
admet-1034	117	10	with	with	ADP
admet-1034	117	11	data	datum	NOUN
admet-1034	117	12	of	of	ADP
admet-1034	117	13	drugs	drug	NOUN
admet-1034	117	14	’	'	PUNCT
admet-1034	117	15	passage	passage	NOUN
admet-1034	117	16	through	through	ADP
admet-1034	117	17	complex	complex	ADJ
admet-1034	117	18	barriers	barrier	NOUN
admet-1034	117	19	,	,	PUNCT
admet-1034	117	20	including	include	VERB
admet-1034	117	21	the	the	DET
admet-1034	117	22	bbb	bbb	NOUN
admet-1034	118	1	[	[	X
admet-1034	118	2	40	40	NUM
admet-1034	118	3	]	]	PUNCT
admet-1034	118	4	.	.	PUNCT
admet-1034	119	1	however	however	ADV
admet-1034	119	2	,	,	PUNCT
admet-1034	119	3	the	the	DET
admet-1034	119	4	extremely	extremely	ADV
admet-1034	119	5	scattered	scatter	VERB
admet-1034	119	6	data	datum	NOUN
admet-1034	119	7	points	point	NOUN
admet-1034	119	8	of	of	ADP
admet-1034	119	9	figure	figure	NOUN
admet-1034	119	10	2	2	NUM
admet-1034	119	11	evidence	evidence	NOUN
admet-1034	119	12	that	that	SCONJ
admet-1034	119	13	no	no	DET
admet-1034	119	14	relationship	relationship	NOUN
admet-1034	119	15	between	between	ADP
admet-1034	119	16	log	log	NOUN
admet-1034	119	17	p	p	NOUN
admet-1034	119	18	and	and	CCONJ
admet-1034	119	19	log	log	VERB
admet-1034	119	20	bb	bb	NOUN
admet-1034	119	21	values	value	NOUN
admet-1034	119	22	can	can	AUX
admet-1034	119	23	be	be	AUX
admet-1034	119	24	observed	observe	VERB
admet-1034	119	25	.	.	PUNCT
admet-1034	120	1	likewise	likewise	ADV
admet-1034	120	2	,	,	PUNCT
admet-1034	120	3	no	no	DET
admet-1034	120	4	trend	trend	NOUN
admet-1034	120	5	is	be	AUX
admet-1034	120	6	visible	visible	ADJ
admet-1034	120	7	between	between	ADP
admet-1034	120	8	the	the	DET
admet-1034	120	9	two	two	NUM
admet-1034	120	10	considered	consider	VERB
admet-1034	120	11	variables	variable	NOUN
admet-1034	120	12	if	if	SCONJ
admet-1034	120	13	all	all	DET
admet-1034	120	14	the	the	DET
admet-1034	120	15	compounds	compound	NOUN
admet-1034	120	16	are	be	AUX
admet-1034	120	17	considered	consider	VERB
admet-1034	120	18	.	.	PUNCT
admet-1034	121	1	however	however	ADV
admet-1034	121	2	,	,	PUNCT
admet-1034	121	3	an	an	DET
admet-1034	121	4	ascending	ascend	VERB
admet-1034	121	5	trend	trend	NOUN
admet-1034	121	6	is	be	AUX
admet-1034	121	7	visible	visible	ADJ
admet-1034	121	8	for	for	ADP
admet-1034	121	9	acidic	acidic	ADJ
admet-1034	121	10	compounds	compound	NOUN
admet-1034	121	11	,	,	PUNCT
admet-1034	121	12	albeit	albeit	SCONJ
admet-1034	121	13	their	their	PRON
admet-1034	121	14	number	number	NOUN
admet-1034	121	15	is	be	AUX
admet-1034	121	16	limited	limited	ADJ
admet-1034	121	17	.	.	PUNCT
admet-1034	122	1	figure	figure	NOUN
admet-1034	122	2	2	2	NUM
admet-1034	122	3	.	.	PUNCT
admet-1034	123	1	relationships	relationship	NOUN
admet-1034	123	2	between	between	ADP
admet-1034	123	3	log	log	NOUN
admet-1034	123	4	bb	bb	NUM
admet-1034	123	5	values	value	NOUN
admet-1034	123	6	and	and	CCONJ
admet-1034	123	7	log	log	VERB
admet-1034	123	8	p	p	NOUN
admet-1034	123	9	values	value	NOUN
admet-1034	123	10	.	.	PUNCT
admet-1034	124	1	conversely	conversely	ADV
admet-1034	124	2	,	,	PUNCT
admet-1034	124	3	the	the	DET
admet-1034	124	4	situation	situation	NOUN
admet-1034	124	5	changes	change	VERB
admet-1034	124	6	noticeably	noticeably	ADV
admet-1034	124	7	when	when	SCONJ
admet-1034	124	8	considering	consider	VERB
admet-1034	124	9	only	only	ADV
admet-1034	124	10	the	the	DET
admet-1034	124	11	lowest	low	ADJ
admet-1034	124	12	range	range	NOUN
admet-1034	124	13	of	of	ADP
admet-1034	124	14	log	log	NOUN
admet-1034	124	15	bb	bb	INTJ
admet-1034	124	16	(	(	PUNCT
admet-1034	124	17	<	<	X
admet-1034	124	18	-0.20	-0.20	NUM
admet-1034	124	19	)	)	PUNCT
admet-1034	124	20	.	.	PUNCT
admet-1034	125	1	indeed	indeed	ADV
admet-1034	125	2	,	,	PUNCT
admet-1034	125	3	as	as	SCONJ
admet-1034	125	4	figure	figure	NOUN
admet-1034	125	5	3	3	NUM
admet-1034	125	6	displays	display	NOUN
admet-1034	125	7	,	,	PUNCT
admet-1034	125	8	the	the	DET
admet-1034	125	9	relationship	relationship	NOUN
admet-1034	125	10	between	between	ADP
admet-1034	125	11	log	log	NOUN
admet-1034	125	12	bb	bb	INTJ
admet-1034	125	13	and	and	CCONJ
admet-1034	125	14	cδ	cδ	NOUN
admet-1034	125	15	/	/	SYM
admet-1034	125	16	δ’log	δ’log	NOUN
admet-1034	125	17	kw	kw	PROPN
admet-1034	125	18	iam	iam	PROPN
admet-1034	125	19	becomes	become	VERB
admet-1034	125	20	inverse	inverse	ADJ
admet-1034	125	21	linear	linear	NOUN
admet-1034	125	22	for	for	ADP
admet-1034	125	23	this	this	DET
admet-1034	125	24	subset	subset	NOUN
admet-1034	125	25	with	with	ADP
admet-1034	125	26	a	a	DET
admet-1034	125	27	rather	rather	ADV
admet-1034	125	28	solid	solid	ADJ
admet-1034	125	29	r2	r2	NOUN
admet-1034	125	30	value	value	NOUN
admet-1034	125	31	,	,	PUNCT
admet-1034	125	32	i.e.	i.e.	X
admet-1034	125	33	,	,	PUNCT
admet-1034	125	34	>	>	X
admet-1034	125	35	0.59	0.59	NUM
admet-1034	125	36	,	,	PUNCT
admet-1034	125	37	with	with	ADP
admet-1034	125	38	a	a	DET
admet-1034	125	39	superior	superior	ADJ
admet-1034	125	40	accuracy	accuracy	NOUN
admet-1034	125	41	afforded	afford	VERB
admet-1034	125	42	by	by	ADP
admet-1034	125	43	delta	delta	NOUN
admet-1034	125	44	values	value	NOUN
admet-1034	125	45	on	on	ADP
admet-1034	125	46	the	the	DET
admet-1034	125	47	dd2	dd2	PROPN
admet-1034	125	48	phase	phase	NOUN
admet-1034	125	49	.	.	PUNCT
admet-1034	126	1	this	this	PRON
admet-1034	126	2	is	be	AUX
admet-1034	126	3	analogous	analogous	ADJ
admet-1034	126	4	to	to	ADP
admet-1034	126	5	what	what	PRON
admet-1034	126	6	we	we	PRON
admet-1034	126	7	achieved	achieve	VERB
admet-1034	126	8	using	use	VERB
admet-1034	126	9	delta	delta	NOUN
admet-1034	126	10	values	value	NOUN
admet-1034	126	11	obtained	obtain	VERB
admet-1034	126	12	from	from	ADP
admet-1034	126	13	experimentally	experimentally	ADV
admet-1034	126	14	determined	determine	VERB
admet-1034	126	15	log	log	NOUN
admet-1034	126	16	kw	kw	PROPN
admet-1034	126	17	iam	iam	PROPN
admet-1034	126	18	values	value	VERB
admet-1034	126	19	[	[	X
admet-1034	126	20	14	14	NUM
admet-1034	126	21	-	-	SYM
admet-1034	126	22	19,34	19,34	NUM
admet-1034	126	23	]	]	PUNCT
admet-1034	126	24	instead	instead	ADV
admet-1034	126	25	of	of	ADP
admet-1034	126	26	the	the	DET
admet-1034	126	27	calculated	calculate	VERB
admet-1034	126	28	ones	one	NOUN
admet-1034	126	29	.	.	PUNCT
admet-1034	127	1	we	we	PRON
admet-1034	127	2	subsequently	subsequently	ADV
admet-1034	127	3	compared	compare	VERB
admet-1034	127	4	the	the	DET
admet-1034	127	5	performance	performance	NOUN
admet-1034	127	6	in	in	ADP
admet-1034	127	7	predicting	predict	VERB
admet-1034	127	8	log	log	NOUN
admet-1034	127	9	bb	bb	NUM
admet-1034	127	10	values	value	NOUN
admet-1034	127	11	of	of	ADP
admet-1034	127	12	delta	delta	NOUN
admet-1034	127	13	descriptors	descriptor	NOUN
admet-1034	127	14	again	again	ADV
admet-1034	127	15	vs.	vs.	ADP
admet-1034	127	16	experimentally	experimentally	ADV
admet-1034	127	17	determined	determine	VERB
admet-1034	127	18	log	log	NOUN
admet-1034	127	19	pn	pn	PROPN
admet-1034	127	20	values	value	NOUN
admet-1034	127	21	(	(	PUNCT
admet-1034	127	22	detailed	detail	VERB
admet-1034	127	23	in	in	ADP
admet-1034	127	24	figure	figure	NOUN
admet-1034	127	25	4	4	NUM
admet-1034	127	26	)	)	PUNCT
admet-1034	127	27	.	.	PUNCT
admet-1034	128	1	although	although	SCONJ
admet-1034	128	2	a	a	DET
admet-1034	128	3	direct	direct	ADJ
admet-1034	128	4	linear	linear	NOUN
admet-1034	128	5	relationship	relationship	NOUN
admet-1034	128	6	is	be	AUX
admet-1034	128	7	observable	observable	ADJ
admet-1034	128	8	between	between	ADP
admet-1034	128	9	log	log	PROPN
admet-1034	128	10	bb	bb	INTJ
admet-1034	128	11	(	(	PUNCT
admet-1034	128	12	<	<	X
admet-1034	128	13	-0.20	-0.20	NUM
admet-1034	128	14	)	)	PUNCT
admet-1034	128	15	and	and	CCONJ
admet-1034	128	16	log	log	VERB
admet-1034	128	17	pn	pn	PROPN
admet-1034	128	18	values	value	NOUN
admet-1034	128	19	,	,	PUNCT
admet-1034	128	20	its	its	PRON
admet-1034	128	21	accuracy	accuracy	NOUN
admet-1034	128	22	as	as	SCONJ
admet-1034	128	23	assessed	assess	VERB
admet-1034	128	24	from	from	ADP
admet-1034	128	25	r2	r2	PROPN
admet-1034	128	26	is	be	AUX
admet-1034	128	27	inferior	inferior	ADJ
admet-1034	128	28	to	to	ADP
admet-1034	128	29	that	that	PRON
admet-1034	128	30	of	of	ADP
admet-1034	128	31	the	the	DET
admet-1034	128	32	relationship	relationship	NOUN
admet-1034	128	33	developed	develop	VERB
admet-1034	128	34	from	from	ADP
admet-1034	128	35	cδ	cδ	NOUN
admet-1034	128	36	/	/	SYM
admet-1034	128	37	δ’log	δ’log	NOUN
admet-1034	128	38	kw	kw	PROPN
admet-1034	128	39	iam.dd2	iam.dd2	NOUN
admet-1034	128	40	values	value	NOUN
admet-1034	128	41	.	.	PUNCT
admet-1034	129	1	if	if	SCONJ
admet-1034	129	2	cδ	cδ	NOUN
admet-1034	129	3	/	/	SYM
admet-1034	129	4	δ’log	δ’log	NOUN
admet-1034	129	5	kw	kw	PROPN
admet-1034	129	6	iam	iam	PROPN
admet-1034	129	7	are	be	AUX
admet-1034	129	8	calculated	calculate	VERB
admet-1034	129	9	from	from	ADP
admet-1034	129	10	in	in	ADP
admet-1034	129	11	silico	silico	NOUN
admet-1034	129	12	rather	rather	ADV
admet-1034	129	13	than	than	ADP
admet-1034	129	14	experimental	experimental	ADJ
admet-1034	129	15	log	log	NOUN
admet-1034	129	16	p	p	PROPN
admet-1034	129	17	data	datum	NOUN
admet-1034	129	18	,	,	PUNCT
admet-1034	129	19	the	the	DET
admet-1034	129	20	relationship	relationship	NOUN
admet-1034	129	21	between	between	ADP
admet-1034	129	22	log	log	NOUN
admet-1034	129	23	bb	bb	INTJ
admet-1034	129	24	(	(	PUNCT
admet-1034	129	25	<	<	X
admet-1034	129	26	-0.20	-0.20	NUM
admet-1034	129	27	)	)	PUNCT
admet-1034	129	28	and	and	CCONJ
admet-1034	129	29	cδ	cδ	ADJ
admet-1034	129	30	/	/	SYM
admet-1034	129	31	δ’log	δ’log	NOUN
admet-1034	129	32	kw	kw	PROPN
admet-1034	129	33	iam	iam	PROPN
admet-1034	129	34	values	value	NOUN
admet-1034	129	35	weaken	weaken	VERB
admet-1034	129	36	,	,	PUNCT
admet-1034	129	37	although	although	SCONJ
admet-1034	129	38	not	not	PART
admet-1034	129	39	much	much	ADJ
admet-1034	129	40	,	,	PUNCT
admet-1034	129	41	especially	especially	ADV
admet-1034	129	42	on	on	ADP
admet-1034	129	43	the	the	DET
admet-1034	129	44	dd2	dd2	PROPN
admet-1034	129	45	phase	phase	NOUN
admet-1034	129	46	(	(	PUNCT
admet-1034	129	47	r2=	r2=	PROPN
admet-1034	129	48	0.68	0.68	NUM
admet-1034	129	49	by	by	ADP
admet-1034	129	50	using	use	VERB
admet-1034	129	51	clogp	clogp	ADJ
admet-1034	129	52	values	value	NOUN
admet-1034	129	53	calculated	calculate	VERB
admet-1034	129	54	by	by	ADP
admet-1034	129	55	marvinsketch	marvinsketch	PROPN
admet-1034	129	56	,	,	PUNCT
admet-1034	129	57	data	datum	NOUN
admet-1034	129	58	not	not	PART
admet-1034	129	59	shown	show	VERB
admet-1034	129	60	)	)	PUNCT
admet-1034	129	61	.	.	PUNCT
admet-1034	130	1	although	although	SCONJ
admet-1034	130	2	the	the	DET
admet-1034	130	3	size	size	NOUN
admet-1034	130	4	of	of	ADP
admet-1034	130	5	our	our	PRON
admet-1034	130	6	dataset	dataset	NOUN
admet-1034	130	7	is	be	AUX
admet-1034	130	8	relatively	relatively	ADV
admet-1034	130	9	limited	limited	ADJ
admet-1034	130	10	(	(	PUNCT
admet-1034	130	11	n	n	NOUN
admet-1034	130	12	=	=	SYM
admet-1034	130	13	56	56	NUM
admet-1034	130	14	)	)	PUNCT
admet-1034	130	15	,	,	PUNCT
admet-1034	130	16	we	we	PRON
admet-1034	130	17	can	can	AUX
admet-1034	130	18	extract	extract	VERB
admet-1034	130	19	some	some	DET
admet-1034	130	20	interesting	interesting	ADJ
admet-1034	130	21	information	information	NOUN
admet-1034	130	22	from	from	ADP
admet-1034	130	23	the	the	DET
admet-1034	130	24	results	result	NOUN
admet-1034	130	25	achieved	achieve	VERB
admet-1034	130	26	.	.	PUNCT
admet-1034	131	1	specifically	specifically	ADV
admet-1034	131	2	,	,	PUNCT
admet-1034	131	3	the	the	DET
admet-1034	131	4	method	method	NOUN
admet-1034	131	5	for	for	ADP
admet-1034	131	6	predicting	predict	VERB
admet-1034	131	7	cδ	cδ	NOUN
admet-1034	131	8	/	/	SYM
admet-1034	131	9	δ’log	δ’log	NOUN
admet-1034	131	10	kw	kw	PROPN
admet-1034	131	11	iam	iam	PROPN
admet-1034	131	12	can	can	AUX
admet-1034	131	13	not	not	PART
admet-1034	131	14	yet	yet	ADV
admet-1034	131	15	be	be	AUX
admet-1034	131	16	used	use	VERB
admet-1034	131	17	alone	alone	ADV
admet-1034	131	18	in	in	ADP
admet-1034	131	19	the	the	DET
admet-1034	131	20	discovery	discovery	NOUN
admet-1034	131	21	phase	phase	NOUN
admet-1034	131	22	.	.	PUNCT
admet-1034	132	1	however	however	ADV
admet-1034	132	2	,	,	PUNCT
admet-1034	132	3	this	this	PRON
admet-1034	132	4	can	can	AUX
admet-1034	132	5	be	be	AUX
admet-1034	132	6	run	run	VERB
admet-1034	132	7	as	as	ADV
admet-1034	132	8	complementary	complementary	ADJ
admet-1034	132	9	along	along	ADP
admet-1034	132	10	with	with	ADP
admet-1034	132	11	other	other	ADJ
admet-1034	132	12	assays	assay	NOUN
admet-1034	132	13	for	for	ADP
admet-1034	132	14	profiling	profile	VERB
admet-1034	132	15	the	the	DET
admet-1034	132	16	adme	adme	NOUN
admet-1034	132	17	potential	potential	NOUN
admet-1034	132	18	of	of	ADP
admet-1034	132	19	drug	drug	NOUN
admet-1034	132	20	candidates	candidate	NOUN
admet-1034	132	21	as	as	SCONJ
admet-1034	132	22	it	it	PRON
admet-1034	132	23	can	can	AUX
admet-1034	132	24	provide	provide	VERB
admet-1034	132	25	additional	additional	ADJ
admet-1034	132	26	information	information	NOUN
admet-1034	132	27	that	that	PRON
admet-1034	132	28	is	be	AUX
admet-1034	132	29	not	not	PART
admet-1034	132	30	afforded	afford	VERB
admet-1034	132	31	by	by	ADP
admet-1034	132	32	other	other	ADJ
admet-1034	132	33	early	early	ADJ
admet-1034	132	34	assessments	assessment	NOUN
admet-1034	132	35	,	,	PUNCT
admet-1034	132	36	e.g.	e.g.	ADV
admet-1034	132	37	,	,	PUNCT
admet-1034	132	38	lipophilicity	lipophilicity	NOUN
admet-1034	132	39	.	.	PUNCT
admet-1034	133	1	moreover	moreover	ADV
admet-1034	133	2	,	,	PUNCT
admet-1034	133	3	the	the	DET
admet-1034	133	4	method	method	NOUN
admet-1034	133	5	hereby	hereby	ADV
admet-1034	133	6	reported	report	VERB
admet-1034	133	7	seems	seem	VERB
admet-1034	133	8	to	to	PART
admet-1034	133	9	be	be	AUX
admet-1034	133	10	more	more	ADV
admet-1034	133	11	selective	selective	ADJ
admet-1034	133	12	in	in	ADP
admet-1034	133	13	the	the	DET
admet-1034	133	14	identification	identification	NOUN
admet-1034	133	15	of	of	ADP
admet-1034	133	16	the	the	DET
admet-1034	133	17	candidates	candidate	NOUN
admet-1034	133	18	with	with	ADP
admet-1034	133	19	the	the	DET
admet-1034	133	20	slimmest	slim	ADJ
admet-1034	133	21	chances	chance	NOUN
admet-1034	133	22	to	to	PART
admet-1034	133	23	gain	gain	VERB
admet-1034	133	24	access	access	NOUN
admet-1034	133	25	to	to	ADP
admet-1034	133	26	the	the	DET
admet-1034	133	27	brain	brain	NOUN
admet-1034	133	28	.	.	PUNCT
admet-1034	134	1	this	this	PRON
admet-1034	134	2	is	be	AUX
admet-1034	134	3	advantageous	advantageous	ADJ
admet-1034	134	4	,	,	PUNCT
admet-1034	134	5	especially	especially	ADV
admet-1034	134	6	if	if	SCONJ
admet-1034	134	7	the	the	DET
admet-1034	134	8	potency	potency	NOUN
admet-1034	134	9	of	of	ADP
admet-1034	134	10	the	the	DET
admet-1034	134	11	candidates	candidate	NOUN
admet-1034	134	12	that	that	PRON
admet-1034	134	13	are	be	AUX
admet-1034	134	14	screened	screen	VERB
admet-1034	134	15	is	be	AUX
admet-1034	134	16	high	high	ADJ
admet-1034	134	17	enough	enough	ADV
admet-1034	134	18	to	to	PART
admet-1034	134	19	be	be	AUX
admet-1034	134	20	effective	effective	ADJ
admet-1034	134	21	,	,	PUNCT
admet-1034	134	22	even	even	ADV
admet-1034	134	23	if	if	SCONJ
admet-1034	134	24	the	the	DET
admet-1034	134	25	amounts	amount	NOUN
admet-1034	134	26	that	that	PRON
admet-1034	134	27	are	be	AUX
admet-1034	134	28	successfully	successfully	ADV
admet-1034	134	29	delivered	deliver	VERB
admet-1034	134	30	to	to	ADP
admet-1034	134	31	the	the	DET
admet-1034	134	32	brain	brain	NOUN
admet-1034	134	33	are	be	AUX
admet-1034	134	34	low	low	ADJ
admet-1034	134	35	.	.	PUNCT
admet-1034	135	1	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	136	1	grumetto	grumetto	NOUN
admet-1034	136	2	and	and	CCONJ
admet-1034	136	3	russo	russo	PROPN
admet-1034	136	4	admet	admet	PROPN
admet-1034	136	5	&	&	CCONJ
admet-1034	136	6	dmpk	dmpk	PROPN
admet-1034	136	7	9(4	9(4	PROPN
admet-1034	136	8	)	)	PUNCT
admet-1034	136	9	(	(	PUNCT
admet-1034	136	10	2021	2021	NUM
admet-1034	136	11	)	)	PUNCT
admet-1034	136	12	267	267	NUM
admet-1034	136	13	-	-	SYM
admet-1034	136	14	281	281	NUM
admet-1034	136	15	276	276	NUM
admet-1034	136	16	figure	figure	NOUN
admet-1034	136	17	3	3	NUM
admet-1034	136	18	.	.	PUNCT
admet-1034	137	1	relationships	relationship	NOUN
admet-1034	137	2	beween	beween	PROPN
admet-1034	137	3	log	log	NOUN
admet-1034	137	4	bb	bb	NUM
admet-1034	137	5	values	value	NOUN
admet-1034	137	6	(	(	PUNCT
admet-1034	137	7	<	<	NOUN
admet-1034	137	8	0.20	0.20	NUM
admet-1034	137	9	)	)	PUNCT
admet-1034	137	10	and	and	CCONJ
admet-1034	137	11	c/’log	c/’log	NOUN
admet-1034	137	12	kw	kw	PROPN
admet-1034	137	13	iam.mg	iam.mg	PROPN
admet-1034	137	14	(	(	PUNCT
admet-1034	137	15	a	a	NOUN
admet-1034	137	16	)	)	PUNCT
admet-1034	137	17	and	and	CCONJ
admet-1034	137	18	c/’log	c/’log	NOUN
admet-1034	137	19	kw	kw	PROPN
admet-1034	137	20	iam.dd2	iam.dd2	NOUN
admet-1034	137	21	values	value	NOUN
admet-1034	137	22	(	(	PUNCT
admet-1034	137	23	b	b	NOUN
admet-1034	137	24	)	)	PUNCT
admet-1034	137	25	.	.	PUNCT
admet-1034	138	1	figure	figure	VERB
admet-1034	138	2	4	4	NUM
admet-1034	138	3	.	.	PUNCT
admet-1034	139	1	relationships	relationship	NOUN
admet-1034	139	2	beween	beween	PROPN
admet-1034	139	3	log	log	NOUN
admet-1034	139	4	bb	bb	INTJ
admet-1034	139	5	(	(	PUNCT
admet-1034	139	6	<	<	NOUN
admet-1034	139	7	0.20	0.20	NUM
admet-1034	139	8	)	)	PUNCT
admet-1034	140	1	and	and	CCONJ
admet-1034	140	2	log	log	VERB
admet-1034	140	3	p	p	NOUN
admet-1034	140	4	values	value	NOUN
admet-1034	140	5	.	.	PUNCT
admet-1034	141	1	these	these	DET
admet-1034	141	2	considerations	consideration	NOUN
admet-1034	141	3	would	would	AUX
admet-1034	141	4	support	support	VERB
admet-1034	141	5	the	the	DET
admet-1034	141	6	implementation	implementation	NOUN
admet-1034	141	7	of	of	ADP
admet-1034	141	8	this	this	DET
admet-1034	141	9	method	method	NOUN
admet-1034	141	10	as	as	ADP
admet-1034	141	11	a	a	DET
admet-1034	141	12	filter	filter	NOUN
admet-1034	141	13	in	in	ADP
admet-1034	141	14	the	the	DET
admet-1034	141	15	discovery	discovery	NOUN
admet-1034	141	16	phase	phase	NOUN
admet-1034	141	17	to	to	PART
admet-1034	141	18	filter	filter	VERB
admet-1034	141	19	out	out	ADP
admet-1034	141	20	the	the	DET
admet-1034	141	21	compounds	compound	NOUN
admet-1034	141	22	intended	intend	VERB
admet-1034	141	23	to	to	PART
admet-1034	141	24	act	act	VERB
admet-1034	141	25	toward	toward	ADP
admet-1034	141	26	the	the	DET
admet-1034	141	27	brain	brain	NOUN
admet-1034	141	28	,	,	PUNCT
admet-1034	141	29	with	with	ADP
admet-1034	141	30	substandard	substandard	ADJ
admet-1034	141	31	potential	potential	NOUN
admet-1034	141	32	to	to	AUX
admet-1034	141	33	partition	partition	NOUN
admet-1034	141	34	in	in	ADP
admet-1034	141	35	the	the	DET
admet-1034	141	36	cns	cns	NOUN
admet-1034	141	37	.	.	PUNCT
admet-1034	142	1	the	the	DET
admet-1034	142	2	method	method	NOUN
admet-1034	142	3	seems	seem	VERB
admet-1034	142	4	to	to	PART
admet-1034	142	5	work	work	VERB
admet-1034	142	6	better	well	ADV
admet-1034	142	7	if	if	SCONJ
admet-1034	142	8	the	the	DET
admet-1034	142	9	estimation	estimation	NOUN
admet-1034	142	10	of	of	ADP
admet-1034	142	11	cδ	cδ	NOUN
admet-1034	142	12	/	/	SYM
admet-1034	142	13	δ’log	δ’log	NOUN
admet-1034	142	14	kw	kw	PROPN
admet-1034	142	15	iam	iam	PROPN
admet-1034	142	16	relies	rely	VERB
admet-1034	142	17	on	on	ADP
admet-1034	142	18	experimental	experimental	ADJ
admet-1034	142	19	lipophilicity	lipophilicity	NOUN
admet-1034	142	20	data	datum	NOUN
admet-1034	142	21	rather	rather	ADV
admet-1034	142	22	than	than	ADP
admet-1034	142	23	calculated	calculated	ADJ
admet-1034	142	24	ones	one	NOUN
admet-1034	142	25	.	.	PUNCT
admet-1034	143	1	this	this	PRON
admet-1034	143	2	is	be	AUX
admet-1034	143	3	not	not	PART
admet-1034	143	4	an	an	DET
admet-1034	143	5	obstacle	obstacle	NOUN
admet-1034	143	6	since	since	SCONJ
admet-1034	143	7	many	many	ADJ
admet-1034	143	8	high	high	ADJ
admet-1034	143	9	throughput	throughput	NOUN
admet-1034	143	10	platforms	platform	NOUN
admet-1034	143	11	for	for	ADP
admet-1034	143	12	log	log	NOUN
admet-1034	143	13	p	p	NOUN
admet-1034	143	14	assessments	assessment	NOUN
admet-1034	143	15	are	be	AUX
admet-1034	143	16	now	now	ADV
admet-1034	143	17	available	available	ADJ
admet-1034	143	18	on	on	ADP
admet-1034	143	19	the	the	DET
admet-1034	143	20	market	market	NOUN
admet-1034	144	1	[	[	X
admet-1034	144	2	41	41	NUM
admet-1034	144	3	]	]	PUNCT
admet-1034	144	4	or	or	CCONJ
admet-1034	144	5	being	be	AUX
admet-1034	144	6	described	describe	VERB
admet-1034	144	7	[	[	X
admet-1034	144	8	42	42	NUM
admet-1034	144	9	]	]	PUNCT
admet-1034	144	10	and	and	CCONJ
admet-1034	144	11	for	for	ADP
admet-1034	144	12	sure	sure	ADJ
admet-1034	144	13	log	log	PROPN
admet-1034	144	14	kw	kw	PROPN
admet-1034	144	15	iam	iam	PROPN
admet-1034	144	16	measurements	measurement	NOUN
admet-1034	144	17	are	be	AUX
admet-1034	144	18	more	more	ADV
admet-1034	144	19	demanding	demanding	ADJ
admet-1034	144	20	since	since	SCONJ
admet-1034	144	21	they	they	PRON
admet-1034	144	22	require	require	VERB
admet-1034	144	23	samples	sample	NOUN
admet-1034	144	24	to	to	PART
admet-1034	144	25	be	be	AUX
admet-1034	144	26	run	run	VERB
admet-1034	144	27	over	over	ADP
admet-1034	144	28	(	(	PUNCT
admet-1034	144	29	at	at	ADP
admet-1034	144	30	least	least	ADJ
admet-1034	144	31	)	)	PUNCT
admet-1034	144	32	three	three	NUM
admet-1034	144	33	organic	organic	ADJ
admet-1034	144	34	modifier	modifier	NOUN
admet-1034	144	35	concentrations	concentration	NOUN
admet-1034	144	36	.	.	PUNCT
admet-1034	145	1	a	a	DET
admet-1034	145	2	further	further	ADJ
admet-1034	145	3	consideration	consideration	NOUN
admet-1034	145	4	concerns	concern	NOUN
admet-1034	145	5	the	the	DET
admet-1034	145	6	models	model	NOUN
admet-1034	145	7	used	use	VERB
admet-1034	145	8	to	to	PART
admet-1034	145	9	calculate	calculate	VERB
admet-1034	145	10	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	145	11	.	.	PUNCT
admet-1034	146	1	these	these	PRON
admet-1034	146	2	are	be	AUX
admet-1034	146	3	already	already	ADV
admet-1034	146	4	rather	rather	ADV
admet-1034	146	5	good	good	ADJ
admet-1034	146	6	but	but	CCONJ
admet-1034	146	7	could	could	AUX
admet-1034	146	8	be	be	AUX
admet-1034	146	9	improved	improve	VERB
admet-1034	146	10	by	by	ADP
admet-1034	146	11	analysing	analyse	VERB
admet-1034	146	12	more	more	ADV
admet-1034	146	13	and	and	CCONJ
admet-1034	146	14	more	more	ADV
admet-1034	146	15	chemically	chemically	ADV
admet-1034	146	16	diverse	diverse	ADJ
admet-1034	146	17	solutes	solute	NOUN
admet-1034	146	18	to	to	PART
admet-1034	146	19	broaden	broaden	VERB
admet-1034	146	20	their	their	PRON
admet-1034	146	21	applicability	applicability	NOUN
admet-1034	146	22	space	space	NOUN
admet-1034	146	23	.	.	PUNCT
admet-1034	147	1	c/’log	c/’log	PROPN
admet-1034	147	2	kw	kw	PROPN
admet-1034	147	3	iam	iam	PROPN
admet-1034	147	4	:	:	PUNCT
admet-1034	147	5	multiple	multiple	ADJ
admet-1034	147	6	linear	linear	ADJ
admet-1034	147	7	regression	regression	VERB
admet-1034	147	8	the	the	DET
admet-1034	147	9	passage	passage	NOUN
admet-1034	147	10	of	of	ADP
admet-1034	147	11	therapeutics	therapeutic	NOUN
admet-1034	147	12	through	through	ADP
admet-1034	147	13	the	the	DET
admet-1034	147	14	bbb	bbb	PROPN
admet-1034	147	15	is	be	AUX
admet-1034	147	16	unanimously	unanimously	ADV
admet-1034	147	17	recognized	recognize	VERB
admet-1034	147	18	as	as	ADP
admet-1034	147	19	an	an	DET
admet-1034	147	20	extremely	extremely	ADV
admet-1034	147	21	complex	complex	ADJ
admet-1034	147	22	admet	admet	NOUN
admet-1034	147	23	&	&	CCONJ
admet-1034	147	24	dmpk	dmpk	PROPN
admet-1034	147	25	9(4	9(4	PROPN
admet-1034	147	26	)	)	PUNCT
admet-1034	147	27	(	(	PUNCT
admet-1034	147	28	2021	2021	NUM
admet-1034	147	29	)	)	PUNCT
admet-1034	147	30	267	267	NUM
admet-1034	147	31	-	-	SYM
admet-1034	147	32	281	281	NUM
admet-1034	147	33	bbb	bbb	PROPN
admet-1034	147	34	passage	passage	NOUN
admet-1034	147	35	based	base	VERB
admet-1034	147	36	on	on	ADP
admet-1034	147	37	in	in	ADP
admet-1034	147	38	silico	silico	NOUN
admet-1034	147	39	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	147	40	doi	doi	NOUN
admet-1034	147	41	:	:	PUNCT
admet-1034	147	42	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	147	43	277	277	NUM
admet-1034	147	44	phenomenon	phenomenon	NOUN
admet-1034	147	45	,	,	PUNCT
admet-1034	147	46	which	which	PRON
admet-1034	147	47	results	result	VERB
admet-1034	147	48	from	from	ADP
admet-1034	147	49	an	an	DET
admet-1034	147	50	interplay	interplay	NOUN
admet-1034	147	51	of	of	ADP
admet-1034	147	52	various	various	ADJ
admet-1034	147	53	passage	passage	NOUN
admet-1034	147	54	patterns	pattern	NOUN
admet-1034	147	55	,	,	PUNCT
admet-1034	147	56	including	include	VERB
admet-1034	147	57	transcellular	transcellular	NOUN
admet-1034	147	58	passive	passive	ADJ
admet-1034	147	59	,	,	PUNCT
admet-1034	147	60	transcellular	transcellular	NOUN
admet-1034	147	61	active	active	ADJ
admet-1034	147	62	and	and	CCONJ
admet-1034	147	63	paracellular	paracellular	ADJ
admet-1034	147	64	passage	passage	NOUN
admet-1034	147	65	pathways	pathway	NOUN
admet-1034	148	1	[	[	X
admet-1034	148	2	43	43	NUM
admet-1034	148	3	]	]	PUNCT
admet-1034	148	4	.	.	PUNCT
admet-1034	149	1	therefore	therefore	ADV
admet-1034	149	2	,	,	PUNCT
admet-1034	149	3	it	it	PRON
admet-1034	149	4	is	be	AUX
admet-1034	149	5	rather	rather	ADV
admet-1034	149	6	unlikely	unlikely	ADJ
admet-1034	149	7	that	that	SCONJ
admet-1034	149	8	a	a	DET
admet-1034	149	9	sole	sole	ADJ
admet-1034	149	10	descriptor	descriptor	NOUN
admet-1034	149	11	can	can	AUX
admet-1034	149	12	encode	encode	VERB
admet-1034	149	13	all	all	DET
admet-1034	149	14	the	the	DET
admet-1034	149	15	interactions	interaction	NOUN
admet-1034	149	16	taking	take	VERB
admet-1034	149	17	place	place	NOUN
admet-1034	149	18	in	in	ADP
admet-1034	149	19	bbb	bbb	PROPN
admet-1034	149	20	uptake	uptake	NOUN
admet-1034	149	21	.	.	PUNCT
admet-1034	150	1	for	for	ADP
admet-1034	150	2	this	this	DET
admet-1034	150	3	reason	reason	NOUN
admet-1034	150	4	,	,	PUNCT
admet-1034	150	5	we	we	PRON
admet-1034	150	6	calculated	calculate	VERB
admet-1034	150	7	an	an	DET
admet-1034	150	8	ample	ample	ADJ
admet-1034	150	9	array	array	NOUN
admet-1034	150	10	(	(	PUNCT
admet-1034	150	11	>	>	X
admet-1034	150	12	1,600	1,600	NUM
admet-1034	150	13	)	)	PUNCT
admet-1034	150	14	of	of	ADP
admet-1034	150	15	physico	physico	NOUN
admet-1034	150	16	-	-	PUNCT
admet-1034	150	17	chemical	chemical	NOUN
admet-1034	150	18	descriptors	descriptor	NOUN
admet-1034	150	19	by	by	ADP
admet-1034	150	20	the	the	DET
admet-1034	150	21	software	software	NOUN
admet-1034	150	22	e	e	NOUN
admet-1034	150	23	-	-	NOUN
admet-1034	150	24	dragon	dragon	ADJ
admet-1034	150	25	1.0	1.0	NUM
admet-1034	150	26	and	and	CCONJ
admet-1034	150	27	studied	study	VERB
admet-1034	150	28	them	they	PRON
admet-1034	150	29	in	in	ADP
admet-1034	150	30	(	(	PUNCT
admet-1034	150	31	i	i	NOUN
admet-1034	150	32	)	)	PUNCT
admet-1034	150	33	simple	simple	ADJ
admet-1034	150	34	linear	linear	ADJ
admet-1034	150	35	regression	regression	NOUN
admet-1034	150	36	and	and	CCONJ
admet-1034	150	37	(	(	PUNCT
admet-1034	150	38	ii	ii	NOUN
admet-1034	150	39	)	)	PUNCT
admet-1034	150	40	multiple	multiple	ADJ
admet-1034	150	41	linear	linear	ADJ
admet-1034	150	42	regression	regression	NOUN
admet-1034	150	43	vs.	vs.	ADP
admet-1034	150	44	log	log	NOUN
admet-1034	150	45	bb	bb	NUM
admet-1034	150	46	values	value	NOUN
admet-1034	150	47	.	.	PUNCT
admet-1034	151	1	task	task	NOUN
admet-1034	151	2	(	(	PUNCT
admet-1034	151	3	i	i	NOUN
admet-1034	151	4	)	)	PUNCT
admet-1034	151	5	was	be	AUX
admet-1034	151	6	done	do	VERB
admet-1034	151	7	to	to	PART
admet-1034	151	8	establish	establish	VERB
admet-1034	151	9	how	how	SCONJ
admet-1034	151	10	c/’log	c/’log	PROPN
admet-1034	151	11	kw	kw	PROPN
admet-1034	151	12	iam	iam	PROPN
admet-1034	151	13	indexes	index	NOUN
admet-1034	151	14	compared	compare	VERB
admet-1034	151	15	to	to	ADP
admet-1034	151	16	other	other	ADJ
admet-1034	151	17	physico	physico	NOUN
admet-1034	151	18	-	-	PUNCT
admet-1034	151	19	chemical	chemical	NOUN
admet-1034	151	20	descriptors	descriptor	NOUN
admet-1034	151	21	in	in	ADP
admet-1034	151	22	terms	term	NOUN
admet-1034	151	23	of	of	ADP
admet-1034	151	24	predictive	predictive	ADJ
admet-1034	151	25	strength	strength	NOUN
admet-1034	151	26	,	,	PUNCT
admet-1034	151	27	while	while	SCONJ
admet-1034	151	28	task	task	NOUN
admet-1034	151	29	(	(	PUNCT
admet-1034	151	30	ii	ii	NOUN
admet-1034	151	31	)	)	PUNCT
admet-1034	151	32	was	be	AUX
admet-1034	151	33	accomplished	accomplish	VERB
admet-1034	151	34	to	to	PART
admet-1034	151	35	study	study	VERB
admet-1034	151	36	whether	whether	SCONJ
admet-1034	151	37	using	use	VERB
admet-1034	151	38	multiple	multiple	ADJ
admet-1034	151	39	variables	variable	NOUN
admet-1034	151	40	to	to	PART
admet-1034	151	41	model	model	VERB
admet-1034	151	42	the	the	DET
admet-1034	151	43	bbb	bbb	PROPN
admet-1034	151	44	passage	passage	NOUN
admet-1034	151	45	of	of	ADP
admet-1034	151	46	the	the	DET
admet-1034	151	47	dataset	dataset	NOUN
admet-1034	151	48	could	could	AUX
admet-1034	151	49	yield	yield	VERB
admet-1034	151	50	some	some	DET
admet-1034	151	51	useful	useful	ADJ
admet-1034	151	52	statistic	statistic	NOUN
admet-1034	151	53	models	model	NOUN
admet-1034	151	54	.	.	PUNCT
admet-1034	152	1	the	the	DET
admet-1034	152	2	results	result	NOUN
admet-1034	152	3	of	of	ADP
admet-1034	152	4	the	the	DET
admet-1034	152	5	simple	simple	ADJ
admet-1034	152	6	linear	linear	ADJ
admet-1034	152	7	regression	regression	NOUN
admet-1034	152	8	analysis	analysis	NOUN
admet-1034	152	9	are	be	AUX
admet-1034	152	10	listed	list	VERB
admet-1034	152	11	in	in	ADP
admet-1034	152	12	table	table	NOUN
admet-1034	152	13	3	3	NUM
admet-1034	152	14	,	,	PUNCT
admet-1034	152	15	along	along	ADP
admet-1034	152	16	with	with	ADP
admet-1034	152	17	the	the	DET
admet-1034	152	18	relevant	relevant	ADJ
admet-1034	152	19	statistics	statistic	NOUN
admet-1034	152	20	.	.	PUNCT
admet-1034	153	1	an	an	DET
admet-1034	153	2	analysis	analysis	NOUN
admet-1034	153	3	of	of	ADP
admet-1034	153	4	the	the	DET
admet-1034	153	5	data	data	NOUN
admet-1034	153	6	suggests	suggest	VERB
admet-1034	153	7	that	that	SCONJ
admet-1034	153	8	all	all	DET
admet-1034	153	9	regression	regression	NOUN
admet-1034	153	10	coefficients	coefficient	NOUN
admet-1034	153	11	are	be	AUX
admet-1034	153	12	significant	significant	ADJ
admet-1034	153	13	at	at	ADP
admet-1034	153	14	the	the	DET
admet-1034	153	15	99	99	NUM
admet-1034	153	16	%	%	NOUN
admet-1034	153	17	level	level	NOUN
admet-1034	153	18	.	.	PUNCT
admet-1034	154	1	among	among	ADP
admet-1034	154	2	all	all	DET
admet-1034	154	3	the	the	DET
admet-1034	154	4	e	e	NOUN
admet-1034	154	5	-	-	ADJ
admet-1034	154	6	dragon	dragon	ADJ
admet-1034	154	7	descriptors	descriptor	NOUN
admet-1034	154	8	,	,	PUNCT
admet-1034	154	9	c/’log	c/’log	NOUN
admet-1034	154	10	kw	kw	INTJ
admet-1034	154	11	iam.dd2	iam.dd2	NOUN
admet-1034	154	12	and	and	CCONJ
admet-1034	154	13	c/’log	c/’log	PROPN
admet-1034	154	14	kw	kw	PROPN
admet-1034	154	15	iam.mg	iam.mg	PROPN
admet-1034	154	16	ranked	rank	VERB
admet-1034	154	17	fourth	fourth	ADJ
admet-1034	154	18	and	and	CCONJ
admet-1034	154	19	fifth	fifth	ADJ
admet-1034	154	20	,	,	PUNCT
admet-1034	154	21	respectively	respectively	ADV
admet-1034	154	22	and	and	CCONJ
admet-1034	154	23	their	their	PRON
admet-1034	154	24	r2	r2	NOUN
admet-1034	154	25	values	value	NOUN
admet-1034	154	26	were	be	AUX
admet-1034	154	27	exceeded	exceed	VERB
admet-1034	154	28	only	only	ADV
admet-1034	154	29	by	by	ADP
admet-1034	154	30	parameters	parameter	NOUN
admet-1034	154	31	referring	refer	VERB
admet-1034	154	32	to	to	ADP
admet-1034	154	33	polarity	polarity	NOUN
admet-1034	154	34	(	(	PUNCT
admet-1034	154	35	tpsa(no	tpsa(no	PROPN
admet-1034	154	36	)	)	PUNCT
admet-1034	154	37	)	)	PUNCT
admet-1034	154	38	,	,	PUNCT
admet-1034	154	39	molecular	molecular	ADJ
admet-1034	154	40	lipophilicity	lipophilicity	NOUN
admet-1034	154	41	(	(	PUNCT
admet-1034	154	42	alogps	alogps	PROPN
admet-1034	154	43	)	)	PUNCT
admet-1034	154	44	,	,	PUNCT
admet-1034	154	45	and	and	CCONJ
admet-1034	154	46	the	the	DET
admet-1034	154	47	number	number	NOUN
admet-1034	154	48	of	of	ADP
admet-1034	154	49	oxygen	oxygen	NOUN
admet-1034	154	50	atoms	atom	NOUN
admet-1034	154	51	(	(	PUNCT
admet-1034	154	52	no	no	NOUN
admet-1034	154	53	)	)	PUNCT
admet-1034	154	54	.	.	PUNCT
admet-1034	155	1	a	a	DET
admet-1034	155	2	detailed	detailed	ADJ
admet-1034	155	3	explanation	explanation	NOUN
admet-1034	155	4	of	of	ADP
admet-1034	155	5	these	these	DET
admet-1034	155	6	and	and	CCONJ
admet-1034	155	7	relevant	relevant	ADJ
admet-1034	155	8	references	reference	NOUN
admet-1034	155	9	is	be	AUX
admet-1034	155	10	reported	report	VERB
admet-1034	155	11	in	in	ADP
admet-1034	155	12	supporting	support	VERB
admet-1034	155	13	information	information	NOUN
admet-1034	155	14	(	(	PUNCT
admet-1034	155	15	table	table	NOUN
admet-1034	155	16	s1	s1	NOUN
admet-1034	155	17	)	)	PUNCT
admet-1034	155	18	.	.	PUNCT
admet-1034	156	1	the	the	DET
admet-1034	156	2	aspect	aspect	NOUN
admet-1034	156	3	that	that	PRON
admet-1034	156	4	both	both	CCONJ
admet-1034	156	5	the	the	DET
admet-1034	156	6	topological	topological	ADJ
admet-1034	156	7	surface	surface	NOUN
admet-1034	156	8	area	area	NOUN
admet-1034	156	9	and	and	CCONJ
admet-1034	156	10	the	the	DET
admet-1034	156	11	number	number	NOUN
admet-1034	156	12	of	of	ADP
admet-1034	156	13	oxygen	oxygen	NOUN
admet-1034	156	14	atoms	atom	NOUN
admet-1034	156	15	relate	relate	VERB
admet-1034	156	16	to	to	ADP
admet-1034	156	17	a	a	DET
admet-1034	156	18	fair	fair	ADJ
admet-1034	156	19	extent	extent	NOUN
admet-1034	156	20	with	with	ADP
admet-1034	156	21	the	the	DET
admet-1034	156	22	bbb	bbb	PROPN
admet-1034	156	23	passage	passage	NOUN
admet-1034	156	24	of	of	ADP
admet-1034	156	25	the	the	DET
admet-1034	156	26	molecules	molecule	NOUN
admet-1034	156	27	in	in	ADP
admet-1034	156	28	the	the	DET
admet-1034	156	29	dataset	dataset	NOUN
admet-1034	156	30	may	may	AUX
admet-1034	156	31	suggest	suggest	VERB
admet-1034	156	32	that	that	SCONJ
admet-1034	156	33	h	h	NOUN
admet-1034	156	34	-	-	PUNCT
admet-1034	156	35	bonding	bonding	NOUN
admet-1034	156	36	may	may	AUX
admet-1034	156	37	act	act	VERB
admet-1034	156	38	by	by	ADP
admet-1034	156	39	preventing	prevent	VERB
admet-1034	156	40	the	the	DET
admet-1034	156	41	uptake	uptake	NOUN
admet-1034	156	42	of	of	ADP
admet-1034	156	43	these	these	DET
admet-1034	156	44	chemicals	chemical	NOUN
admet-1034	156	45	through	through	ADP
admet-1034	156	46	the	the	DET
admet-1034	156	47	bbb	bbb	PROPN
admet-1034	156	48	.	.	PUNCT
admet-1034	157	1	this	this	PRON
admet-1034	157	2	agrees	agree	VERB
admet-1034	157	3	well	well	ADV
admet-1034	157	4	with	with	ADP
admet-1034	157	5	the	the	DET
admet-1034	157	6	observations	observation	NOUN
admet-1034	157	7	made	make	VERB
admet-1034	157	8	by	by	ADP
admet-1034	157	9	diamond	diamond	NOUN
admet-1034	157	10	and	and	CCONJ
admet-1034	157	11	co	co	NOUN
admet-1034	157	12	-	-	NOUN
admet-1034	157	13	workers	worker	NOUN
admet-1034	157	14	[	[	X
admet-1034	157	15	44	44	NUM
admet-1034	157	16	]	]	PUNCT
admet-1034	157	17	and	and	CCONJ
admet-1034	157	18	other	other	ADJ
admet-1034	157	19	research	research	NOUN
admet-1034	157	20	groups	group	NOUN
admet-1034	157	21	[	[	X
admet-1034	157	22	45	45	NUM
admet-1034	157	23	]	]	PUNCT
admet-1034	157	24	.	.	PUNCT
admet-1034	158	1	subsequently	subsequently	ADV
admet-1034	158	2	,	,	PUNCT
admet-1034	158	3	the	the	DET
admet-1034	158	4	incorporation	incorporation	NOUN
admet-1034	158	5	of	of	ADP
admet-1034	158	6	c/’log	c/’log	PROPN
admet-1034	158	7	kw	kw	PROPN
admet-1034	158	8	iam	iam	PROPN
admet-1034	158	9	descriptors	descriptor	NOUN
admet-1034	158	10	was	be	AUX
admet-1034	158	11	attempted	attempt	VERB
admet-1034	158	12	in	in	ADP
admet-1034	158	13	multiple	multiple	ADJ
admet-1034	158	14	linear	linear	ADJ
admet-1034	158	15	regression	regression	NOUN
admet-1034	158	16	reported	report	VERB
admet-1034	158	17	below	below	ADV
admet-1034	158	18	:	:	PUNCT
admet-1034	158	19	log	log	VERB
admet-1034	158	20	bb	bb	NOUN
admet-1034	159	1	=	=	NOUN
admet-1034	159	2	0.0668	0.0668	NUM
admet-1034	159	3	+	+	CCONJ
admet-1034	159	4	0.1548	0.1548	NUM
admet-1034	159	5	alogps_logp	alogps_logp	NOUN
admet-1034	159	6	0.0779	0.0779	NUM
admet-1034	159	7	cδ	cδ	NOUN
admet-1034	159	8	/	/	SYM
admet-1034	159	9	δ’log	δ’log	NOUN
admet-1034	159	10	kw	kw	PROPN
admet-1034	159	11	iam.mg	iam.mg	PROPN
admet-1034	159	12	0.0046	0.0046	NUM
admet-1034	159	13	tpsa(tot	tpsa(tot	NOUN
admet-1034	159	14	)	)	PUNCT
admet-1034	159	15	0.3464	0.3464	NUM
admet-1034	159	16	nroh	nroh	NOUN
admet-1034	159	17	(	(	PUNCT
admet-1034	159	18	6	6	NUM
admet-1034	159	19	)	)	PUNCT
admet-1034	159	20	r2	r2	NOUN
admet-1034	159	21	=	=	PUNCT
admet-1034	159	22	0.73	0.73	NUM
admet-1034	159	23	q2	q2	NOUN
admet-1034	159	24	=	=	SYM
admet-1034	160	1	0.67	0.67	NUM
admet-1034	160	2	se=	se=	PROPN
admet-1034	160	3	0.280	0.280	NUM
admet-1034	160	4	f	f	X
admet-1034	160	5	=	=	SYM
admet-1034	160	6	34.45	34.45	NUM
admet-1034	160	7	p=6.26e-14	p=6.26e-14	NOUN
admet-1034	161	1	pc=4.450	pc=4.450	NOUN
admet-1034	161	2	and	and	CCONJ
admet-1034	161	3	after	after	SCONJ
admet-1034	161	4	loo	loo	NOUN
admet-1034	161	5	:	:	PUNCT
admet-1034	161	6	log	log	VERB
admet-1034	161	7	bb	bb	NOUN
admet-1034	162	1	=	=	PUNCT
admet-1034	162	2	0.0425	0.0425	NUM
admet-1034	162	3	+	+	NUM
admet-1034	162	4	0.1657	0.1657	NUM
admet-1034	162	5	alogps_logp	alogps_logp	NOUN
admet-1034	162	6	0.0609	0.0609	NUM
admet-1034	162	7	cδ	cδ	NOUN
admet-1034	162	8	/	/	SYM
admet-1034	162	9	δ’log	δ’log	NOUN
admet-1034	162	10	kw	kw	PUNCT
admet-1034	162	11	iam.mg	iam.mg	PROPN
admet-1034	162	12	0.0043	0.0043	NUM
admet-1034	162	13	tpsa(tot	tpsa(tot	NOUN
admet-1034	162	14	)	)	PUNCT
admet-1034	162	15	0.3709	0.3709	NUM
admet-1034	162	16	nroh	nroh	NOUN
admet-1034	162	17	(	(	PUNCT
admet-1034	162	18	7	7	NUM
admet-1034	162	19	)	)	PUNCT
admet-1034	162	20	r2	r2	NOUN
admet-1034	162	21	=	=	PUNCT
admet-1034	163	1	0.76	0.76	NUM
admet-1034	163	2	se=	se=	PROPN
admet-1034	163	3	0.266	0.266	NUM
admet-1034	163	4	f	f	X
admet-1034	163	5	=	=	SYM
admet-1034	163	6	38.79	38.79	NUM
admet-1034	163	7	p=9.35e-15	p=9.35e-15	NOUN
admet-1034	163	8	pc=3.93	pc=3.93	PROPN
admet-1034	163	9	exc	exc	NOUN
admet-1034	163	10	:	:	PUNCT
admet-1034	163	11	mesoridazine	mesoridazine	ADJ
admet-1034	163	12	table	table	NOUN
admet-1034	163	13	3	3	NUM
admet-1034	163	14	.	.	PUNCT
admet-1034	163	15	variable	variable	NOUN
admet-1034	163	16	considered	consider	VERB
admet-1034	163	17	and	and	CCONJ
admet-1034	163	18	r	r	NOUN
admet-1034	163	19	2	2	NUM
admet-1034	163	20	vs	vs	ADP
admet-1034	163	21	log	log	NOUN
admet-1034	163	22	bb	bb	NUM
admet-1034	163	23	values	value	NOUN
admet-1034	163	24	.	.	PUNCT
admet-1034	164	1	a	a	DET
admet-1034	164	2	detailed	detailed	ADJ
admet-1034	164	3	description	description	NOUN
admet-1034	164	4	of	of	ADP
admet-1034	164	5	the	the	DET
admet-1034	164	6	descriptors	descriptor	NOUN
admet-1034	164	7	is	be	AUX
admet-1034	164	8	offered	offer	VERB
admet-1034	164	9	in	in	ADP
admet-1034	164	10	supporting	support	VERB
admet-1034	164	11	information	information	NOUN
admet-1034	164	12	(	(	PUNCT
admet-1034	164	13	table	table	NOUN
admet-1034	164	14	s1	s1	NOUN
admet-1034	164	15	)	)	PUNCT
admet-1034	164	16	.	.	PUNCT
admet-1034	165	1	the	the	DET
admet-1034	165	2	statistics	statistic	NOUN
admet-1034	165	3	of	of	ADP
admet-1034	165	4	the	the	DET
admet-1034	165	5	each	each	DET
admet-1034	165	6	regressor	regressor	NOUN
admet-1034	165	7	is	be	AUX
admet-1034	165	8	reported	report	VERB
admet-1034	165	9	in	in	ADP
admet-1034	165	10	2.3	2.3	NUM
admet-1034	165	11	.	.	PUNCT
admet-1034	166	1	the	the	DET
admet-1034	166	2	statistics	statistic	NOUN
admet-1034	166	3	of	of	ADP
admet-1034	166	4	the	the	DET
admet-1034	166	5	equations	equation	NOUN
admet-1034	166	6	has	have	AUX
admet-1034	166	7	been	be	AUX
admet-1034	166	8	detailed	detail	VERB
admet-1034	166	9	in	in	ADP
admet-1034	166	10	2.3	2.3	NUM
admet-1034	166	11	,	,	PUNCT
admet-1034	166	12	while	while	SCONJ
admet-1034	166	13	exc	exc	NOUN
admet-1034	166	14	identifies	identify	VERB
admet-1034	166	15	the	the	DET
admet-1034	166	16	compound	compound	NOUN
admet-1034	166	17	that	that	PRON
admet-1034	166	18	was	be	AUX
admet-1034	166	19	excluded	exclude	VERB
admet-1034	166	20	from	from	ADP
admet-1034	166	21	the	the	DET
admet-1034	166	22	regression	regression	NOUN
admet-1034	166	23	.	.	PUNCT
admet-1034	167	1	according	accord	VERB
admet-1034	167	2	to	to	ADP
admet-1034	167	3	both	both	DET
admet-1034	167	4	equations	equation	NOUN
admet-1034	167	5	(	(	PUNCT
admet-1034	167	6	6	6	NUM
admet-1034	167	7	)	)	PUNCT
admet-1034	167	8	and	and	CCONJ
admet-1034	167	9	(	(	PUNCT
admet-1034	167	10	7	7	NUM
admet-1034	167	11	)	)	PUNCT
admet-1034	167	12	,	,	PUNCT
admet-1034	167	13	the	the	DET
admet-1034	167	14	bbb	bbb	PROPN
admet-1034	167	15	diffusion	diffusion	NOUN
admet-1034	167	16	of	of	ADP
admet-1034	167	17	chemicals	chemical	NOUN
admet-1034	167	18	seems	seem	VERB
admet-1034	167	19	to	to	PART
admet-1034	167	20	be	be	AUX
admet-1034	167	21	promoted	promote	VERB
admet-1034	167	22	by	by	ADP
admet-1034	167	23	molecular	molecular	ADJ
admet-1034	167	24	lipophilicity	lipophilicity	NOUN
admet-1034	167	25	and	and	CCONJ
admet-1034	167	26	hindered	hinder	VERB
admet-1034	167	27	for	for	ADP
admet-1034	167	28	molecules	molecule	NOUN
admet-1034	167	29	featuring	feature	VERB
admet-1034	167	30	high	high	ADJ
admet-1034	167	31	c/’log	c/’log	NOUN
admet-1034	167	32	kw	kw	PRON
admet-1034	167	33	iam.mg	iam.mg	PROPN
admet-1034	167	34	,	,	PUNCT
admet-1034	167	35	which	which	PRON
admet-1034	167	36	is	be	AUX
admet-1034	167	37	an	an	DET
admet-1034	167	38	index	index	NOUN
admet-1034	167	39	accounting	account	VERB
admet-1034	167	40	for	for	ADP
admet-1034	167	41	the	the	DET
admet-1034	167	42	excess	excess	NOUN
admet-1034	167	43	of	of	ADP
admet-1034	167	44	the	the	DET
admet-1034	167	45	polar	polar	ADJ
admet-1034	167	46	/	/	SYM
admet-1034	167	47	electrostatic	electrostatic	ADJ
admet-1034	167	48	interaction	interaction	NOUN
admet-1034	167	49	forces	force	NOUN
admet-1034	167	50	realized	realize	VERB
admet-1034	167	51	in	in	ADP
admet-1034	167	52	the	the	DET
admet-1034	167	53	interplay	interplay	NOUN
admet-1034	167	54	between	between	ADP
admet-1034	167	55	the	the	DET
admet-1034	167	56	chemical	chemical	NOUN
admet-1034	167	57	species	specie	NOUN
admet-1034	167	58	and	and	CCONJ
admet-1034	167	59	membrane	membrane	NOUN
admet-1034	167	60	phospholipids	phospholipid	NOUN
admet-1034	167	61	.	.	PUNCT
admet-1034	168	1	again	again	ADV
admet-1034	168	2	,	,	PUNCT
admet-1034	168	3	according	accord	VERB
admet-1034	168	4	to	to	ADP
admet-1034	168	5	the	the	DET
admet-1034	168	6	models	model	NOUN
admet-1034	168	7	presented	present	VERB
admet-1034	168	8	above	above	ADP
admet-1034	168	9	,	,	PUNCT
admet-1034	168	10	the	the	DET
admet-1034	168	11	bbb	bbb	NOUN
admet-1034	168	12	uptake	uptake	NOUN
admet-1034	168	13	of	of	ADP
admet-1034	168	14	molecules	molecule	NOUN
admet-1034	168	15	is	be	AUX
admet-1034	168	16	less	less	ADV
admet-1034	168	17	efficient	efficient	ADJ
admet-1034	168	18	for	for	ADP
admet-1034	168	19	those	those	PRON
admet-1034	168	20	supporting	support	VERB
admet-1034	168	21	many	many	ADJ
admet-1034	168	22	polar	polar	ADJ
admet-1034	168	23	atoms	atom	NOUN
admet-1034	168	24	(	(	PUNCT
admet-1034	168	25	and	and	CCONJ
admet-1034	168	26	specifically	specifically	ADV
admet-1034	168	27	many	many	ADJ
admet-1034	168	28	hydroxyl	hydroxyl	NOUN
admet-1034	168	29	groups	group	NOUN
admet-1034	168	30	)	)	PUNCT
admet-1034	168	31	.	.	PUNCT
admet-1034	169	1	an	an	DET
admet-1034	169	2	r2	r2	PROPN
admet-1034	169	3	(	(	PUNCT
admet-1034	169	4	n-1	n-1	NUM
admet-1034	169	5	)	)	PUNCT
admet-1034	169	6	value	value	NOUN
admet-1034	169	7	equal	equal	ADJ
admet-1034	169	8	to	to	ADP
admet-1034	169	9	0.76	0.76	NUM
admet-1034	169	10	suggests	suggest	VERB
admet-1034	169	11	that	that	SCONJ
admet-1034	169	12	the	the	DET
admet-1034	169	13	statistic	statistic	ADJ
admet-1034	169	14	model	model	NOUN
admet-1034	169	15	is	be	AUX
admet-1034	169	16	robust	robust	ADJ
admet-1034	169	17	and	and	CCONJ
admet-1034	169	18	reliable	reliable	ADJ
admet-1034	169	19	.	.	PUNCT
admet-1034	170	1	a	a	DET
admet-1034	170	2	plot	plot	NOUN
admet-1034	170	3	experimental	experimental	NOUN
admet-1034	170	4	vs.	vs.	CCONJ
admet-1034	170	5	predicted	predict	VERB
admet-1034	170	6	(	(	PUNCT
admet-1034	170	7	according	accord	VERB
admet-1034	170	8	to	to	ADP
admet-1034	170	9	eq	eq	PROPN
admet-1034	170	10	.	.	PUNCT
admet-1034	170	11	(	(	PUNCT
admet-1034	170	12	7	7	NUM
admet-1034	170	13	)	)	PUNCT
admet-1034	170	14	)	)	PUNCT
admet-1034	170	15	log	log	NOUN
admet-1034	170	16	bb	bb	NOUN
admet-1034	170	17	values	value	NOUN
admet-1034	170	18	is	be	AUX
admet-1034	170	19	presented	present	VERB
admet-1034	170	20	in	in	ADP
admet-1034	170	21	figure	figure	NOUN
admet-1034	170	22	5	5	NUM
admet-1034	170	23	.	.	PUNCT
admet-1034	171	1	the	the	DET
admet-1034	171	2	value	value	NOUN
admet-1034	171	3	of	of	ADP
admet-1034	171	4	each	each	DET
admet-1034	171	5	descriptor	descriptor	NOUN
admet-1034	171	6	is	be	AUX
admet-1034	171	7	reported	report	VERB
admet-1034	171	8	in	in	ADP
admet-1034	171	9	supporting	support	VERB
admet-1034	171	10	information	information	NOUN
admet-1034	171	11	(	(	PUNCT
admet-1034	171	12	table	table	NOUN
admet-1034	171	13	s2	s2	PROPN
admet-1034	171	14	)	)	PUNCT
admet-1034	171	15	.	.	PUNCT
admet-1034	172	1	variable	variable	ADJ
admet-1034	172	2	r	r	NOUN
admet-1034	172	3	2	2	NUM
admet-1034	172	4	q	q	NOUN
admet-1034	172	5	2	2	NUM
admet-1034	172	6	se	se	X
admet-1034	172	7	f	f	PROPN
admet-1034	172	8	p	p	X
admet-1034	172	9	pc	pc	NOUN
admet-1034	172	10	tpsa(no	tpsa(no	PROPN
admet-1034	172	11	)	)	PUNCT
admet-1034	172	12	0.46	0.46	NUM
admet-1034	172	13	0.42	0.42	NUM
admet-1034	172	14	0.385	0.385	NUM
admet-1034	172	15	46.08	46.08	NUM
admet-1034	172	16	9.08e-09	9.08e-09	NUM
admet-1034	172	17	7.985	7.985	NUM
admet-1034	172	18	alogps_logp	alogps_logp	NOUN
admet-1034	172	19	0.42	0.42	NUM
admet-1034	172	20	0.37	0.37	NUM
admet-1034	172	21	0.398	0.398	NUM
admet-1034	172	22	39.36	39.36	NUM
admet-1034	172	23	6.19e-08	6.19e-08	NUM
admet-1034	172	24	8.561	8.561	NUM
admet-1034	172	25	no	no	PRON
admet-1034	172	26	0.38	0.38	NUM
admet-1034	172	27	0.33	0.33	NUM
admet-1034	172	28	0.411	0.411	NUM
admet-1034	172	29	33.46	33.46	NUM
admet-1034	172	30	3.77e-07	3.77e-07	NUM
admet-1034	172	31	9.138	9.138	NUM
admet-1034	172	32	cδ	cδ	NOUN
admet-1034	172	33	/	/	SYM
admet-1034	172	34	δ’log	δ’log	NOUN
admet-1034	172	35	kw	kw	INTJ
admet-1034	172	36	iam.dd2	iam.dd2	ADV
admet-1034	172	37	0.38	0.38	NUM
admet-1034	172	38	0.32	0.32	NUM
admet-1034	172	39	0.413	0.413	NUM
admet-1034	172	40	32.82	32.82	NUM
admet-1034	172	41	5.36e-07	5.36e-07	NUM
admet-1034	172	42	9.205	9.205	NUM
admet-1034	172	43	cδ	cδ	NOUN
admet-1034	172	44	/	/	SYM
admet-1034	172	45	δ’log	δ’log	NOUN
admet-1034	172	46	kw	kw	NOUN
admet-1034	172	47	iam.mg	iam.mg	PROPN
admet-1034	172	48	0.37	0.37	NUM
admet-1034	172	49	0.32	0.32	NUM
admet-1034	172	50	0.414	0.414	NUM
admet-1034	172	51	32.36	32.36	NUM
admet-1034	172	52	5.36e07	5.36e07	NUM
admet-1034	172	53	9.255	9.255	NUM
admet-1034	172	54	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	172	55	grumetto	grumetto	NOUN
admet-1034	172	56	and	and	CCONJ
admet-1034	172	57	russo	russo	PROPN
admet-1034	172	58	admet	admet	PROPN
admet-1034	172	59	&	&	CCONJ
admet-1034	172	60	dmpk	dmpk	PROPN
admet-1034	172	61	9(4	9(4	PROPN
admet-1034	172	62	)	)	PUNCT
admet-1034	172	63	(	(	PUNCT
admet-1034	172	64	2021	2021	NUM
admet-1034	172	65	)	)	PUNCT
admet-1034	172	66	267	267	NUM
admet-1034	172	67	-	-	SYM
admet-1034	172	68	281	281	NUM
admet-1034	172	69	278	278	NUM
admet-1034	172	70	figure	figure	NOUN
admet-1034	172	71	5	5	NUM
admet-1034	172	72	.	.	PUNCT
admet-1034	173	1	experimental	experimental	ADJ
admet-1034	173	2	vs	vs	ADP
admet-1034	173	3	predicted	predict	VERB
admet-1034	173	4	log	log	NOUN
admet-1034	173	5	bb	bb	NOUN
admet-1034	173	6	values	value	NOUN
admet-1034	173	7	calculated	calculate	VERB
admet-1034	173	8	according	accord	VERB
admet-1034	173	9	to	to	ADP
admet-1034	173	10	eq	eq	PROPN
admet-1034	173	11	.	.	PUNCT
admet-1034	174	1	(	(	PUNCT
admet-1034	174	2	7	7	NUM
admet-1034	174	3	)	)	PUNCT
admet-1034	174	4	.	.	PUNCT
admet-1034	175	1	conclusions	conclusion	NOUN
admet-1034	175	2	the	the	DET
admet-1034	175	3	present	present	ADJ
admet-1034	175	4	study	study	NOUN
admet-1034	175	5	proposes	propose	VERB
admet-1034	175	6	a	a	DET
admet-1034	175	7	method	method	NOUN
admet-1034	175	8	to	to	PART
admet-1034	175	9	streamline	streamline	VERB
admet-1034	175	10	the	the	DET
admet-1034	175	11	drug	drug	NOUN
admet-1034	175	12	discovery	discovery	NOUN
admet-1034	175	13	/	/	SYM
admet-1034	175	14	development	development	NOUN
admet-1034	175	15	process	process	NOUN
admet-1034	175	16	and	and	CCONJ
admet-1034	175	17	filter	filter	VERB
admet-1034	175	18	out	out	ADP
admet-1034	175	19	solutes	solute	NOUN
admet-1034	175	20	whose	whose	DET
admet-1034	175	21	bbb	bbb	NOUN
admet-1034	175	22	permeation	permeation	NOUN
admet-1034	175	23	is	be	AUX
admet-1034	175	24	envisaged	envisage	VERB
admet-1034	175	25	to	to	PART
admet-1034	175	26	be	be	AUX
admet-1034	175	27	substandard	substandard	ADJ
admet-1034	175	28	.	.	PUNCT
admet-1034	176	1	even	even	ADV
admet-1034	176	2	if	if	SCONJ
admet-1034	176	3	the	the	DET
admet-1034	176	4	dataset	dataset	NOUN
admet-1034	176	5	is	be	AUX
admet-1034	176	6	limited	limit	VERB
admet-1034	176	7	in	in	ADP
admet-1034	176	8	size	size	NOUN
admet-1034	176	9	and	and	CCONJ
admet-1034	176	10	the	the	DET
admet-1034	176	11	method	method	NOUN
admet-1034	176	12	is	be	AUX
admet-1034	176	13	not	not	PART
admet-1034	176	14	mature	mature	ADJ
admet-1034	176	15	enough	enough	ADV
admet-1034	176	16	for	for	ADP
admet-1034	176	17	broad	broad	ADJ
admet-1034	176	18	implementation	implementation	NOUN
admet-1034	176	19	alone	alone	ADV
admet-1034	176	20	,	,	PUNCT
admet-1034	176	21	it	it	PRON
admet-1034	176	22	may	may	AUX
admet-1034	176	23	be	be	AUX
admet-1034	176	24	applied	apply	VERB
admet-1034	176	25	,	,	PUNCT
admet-1034	176	26	along	along	ADP
admet-1034	176	27	with	with	ADP
admet-1034	176	28	other	other	ADJ
admet-1034	176	29	methodologies	methodology	NOUN
admet-1034	176	30	by	by	ADP
admet-1034	176	31	pharmaceutical	pharmaceutical	ADJ
admet-1034	176	32	companies	company	NOUN
admet-1034	176	33	and	and	CCONJ
admet-1034	176	34	research	research	NOUN
admet-1034	176	35	institutes	institute	NOUN
admet-1034	176	36	,	,	PUNCT
admet-1034	176	37	to	to	PART
admet-1034	176	38	focus	focus	VERB
admet-1034	176	39	only	only	ADV
admet-1034	176	40	on	on	ADP
admet-1034	176	41	candidates	candidate	NOUN
admet-1034	176	42	that	that	PRON
admet-1034	176	43	tend	tend	VERB
admet-1034	176	44	to	to	PART
admet-1034	176	45	concentrate	concentrate	VERB
admet-1034	176	46	on	on	ADP
admet-1034	176	47	the	the	DET
admet-1034	176	48	brain	brain	NOUN
admet-1034	176	49	.	.	PUNCT
admet-1034	177	1	this	this	DET
admet-1034	177	2	way	way	NOUN
admet-1034	177	3	,	,	PUNCT
admet-1034	177	4	all	all	DET
admet-1034	177	5	the	the	DET
admet-1034	177	6	others	other	NOUN
admet-1034	177	7	can	can	AUX
admet-1034	177	8	be	be	AUX
admet-1034	177	9	neglected	neglect	VERB
admet-1034	177	10	,	,	PUNCT
admet-1034	177	11	thus	thus	ADV
admet-1034	177	12	saving	save	VERB
admet-1034	177	13	time	time	NOUN
admet-1034	177	14	and	and	CCONJ
admet-1034	177	15	money	money	NOUN
admet-1034	177	16	resources	resource	NOUN
admet-1034	177	17	.	.	PUNCT
admet-1034	178	1	conflict	conflict	NOUN
admet-1034	178	2	of	of	ADP
admet-1034	178	3	interest	interest	NOUN
admet-1034	178	4	:	:	PUNCT
admet-1034	178	5	the	the	DET
admet-1034	178	6	authors	author	NOUN
admet-1034	178	7	lg	lg	PROPN
admet-1034	178	8	and	and	CCONJ
admet-1034	178	9	gr	gr	PROPN
admet-1034	178	10	do	do	AUX
admet-1034	178	11	not	not	PART
admet-1034	178	12	have	have	VERB
admet-1034	178	13	any	any	DET
admet-1034	178	14	competing	compete	VERB
admet-1034	178	15	financial	financial	ADJ
admet-1034	178	16	interests	interest	NOUN
admet-1034	178	17	to	to	PART
admet-1034	178	18	disclose	disclose	VERB
admet-1034	178	19	.	.	PUNCT
admet-1034	179	1	references	reference	NOUN
admet-1034	179	2	[	[	X
admet-1034	179	3	1	1	NUM
admet-1034	179	4	]	]	X
admet-1034	179	5	j.p	j.p	PROPN
admet-1034	179	6	.	.	PROPN
admet-1034	179	7	kennedy	kennedy	PROPN
admet-1034	179	8	,	,	PUNCT
admet-1034	179	9	l.	l.	PROPN
admet-1034	179	10	williams	williams	PROPN
admet-1034	179	11	,	,	PUNCT
admet-1034	179	12	t.m	t.m	PROPN
admet-1034	179	13	.	.	PROPN
admet-1034	179	14	bridges	bridge	NOUN
admet-1034	179	15	,	,	PUNCT
admet-1034	179	16	r.n	r.n	PROPN
admet-1034	179	17	.	.	PROPN
admet-1034	179	18	daniels	daniels	PROPN
admet-1034	179	19	,	,	PUNCT
admet-1034	179	20	d.	d.	PROPN
admet-1034	179	21	weaver	weaver	PROPN
admet-1034	179	22	,	,	PUNCT
admet-1034	179	23	c.w	c.w	PROPN
admet-1034	179	24	.	.	PROPN
admet-1034	179	25	lindsley	lindsley	PROPN
admet-1034	179	26	.	.	PUNCT
admet-1034	180	1	application	application	NOUN
admet-1034	180	2	of	of	ADP
admet-1034	180	3	combinatorial	combinatorial	ADJ
admet-1034	180	4	chemistry	chemistry	NOUN
admet-1034	180	5	science	science	NOUN
admet-1034	180	6	on	on	ADP
admet-1034	180	7	modern	modern	ADJ
admet-1034	180	8	drug	drug	NOUN
admet-1034	180	9	discovery	discovery	NOUN
admet-1034	180	10	.	.	PUNCT
admet-1034	181	1	j.	j.	PROPN
admet-1034	181	2	comb	comb	PROPN
admet-1034	181	3	.	.	PUNCT
admet-1034	182	1	chem	chem	NOUN
admet-1034	182	2	.	.	PUNCT
admet-1034	183	1	10	10	NUM
admet-1034	183	2	(	(	PUNCT
admet-1034	183	3	2008	2008	NUM
admet-1034	183	4	)	)	PUNCT
admet-1034	183	5	345	345	NUM
admet-1034	183	6	-	-	SYM
admet-1034	183	7	354	354	NUM
admet-1034	183	8	.	.	PUNCT
admet-1034	184	1	https://dx.doi.org/10.1021/cc700187	https://dx.doi.org/10.1021/cc700187	PROPN
admet-1034	185	1	t.	t.	X
admet-1034	185	2	[	[	X
admet-1034	185	3	2	2	NUM
admet-1034	185	4	]	]	X
admet-1034	185	5	j.p	j.p	PROPN
admet-1034	185	6	.	.	PROPN
admet-1034	185	7	renaud	renaud	PROPN
admet-1034	185	8	,	,	PUNCT
admet-1034	185	9	c.w	c.w	PROPN
admet-1034	185	10	.	.	PROPN
admet-1034	185	11	chung	chung	PROPN
admet-1034	185	12	,	,	PUNCT
admet-1034	185	13	u.h	u.h	PROPN
admet-1034	185	14	.	.	PROPN
admet-1034	185	15	danielson	danielson	PROPN
admet-1034	185	16	,	,	PUNCT
admet-1034	185	17	u.	u.	PROPN
admet-1034	185	18	egner	egner	PROPN
admet-1034	185	19	,	,	PUNCT
admet-1034	185	20	m.	m.	PROPN
admet-1034	185	21	hennig	hennig	PROPN
admet-1034	185	22	,	,	PUNCT
admet-1034	185	23	r.e	r.e	PROPN
admet-1034	185	24	.	.	PROPN
admet-1034	185	25	hubbard	hubbard	PROPN
admet-1034	185	26	,	,	PUNCT
admet-1034	185	27	h.	h.	NOUN
admet-1034	185	28	nar	nar	NOUN
admet-1034	185	29	.	.	PUNCT
admet-1034	186	1	biophysics	biophysic	NOUN
admet-1034	186	2	in	in	ADP
admet-1034	186	3	drug	drug	NOUN
admet-1034	186	4	discovery	discovery	NOUN
admet-1034	186	5	:	:	PUNCT
admet-1034	186	6	impact	impact	NOUN
admet-1034	186	7	,	,	PUNCT
admet-1034	186	8	challenges	challenge	NOUN
admet-1034	186	9	and	and	CCONJ
admet-1034	186	10	opportunities	opportunity	NOUN
admet-1034	186	11	.	.	PUNCT
admet-1034	187	1	nat	nat	PROPN
admet-1034	187	2	.	.	PUNCT
admet-1034	188	1	rev	rev	PROPN
admet-1034	188	2	.	.	PROPN
admet-1034	188	3	drug	drug	NOUN
admet-1034	188	4	discov	discov	NOUN
admet-1034	188	5	.	.	PUNCT
admet-1034	189	1	15	15	NUM
admet-1034	189	2	(	(	PUNCT
admet-1034	189	3	2016	2016	NUM
admet-1034	189	4	)	)	PUNCT
admet-1034	189	5	679	679	NUM
admet-1034	189	6	-	-	SYM
admet-1034	189	7	698	698	NUM
admet-1034	189	8	,	,	PUNCT
admet-1034	189	9	https://dx.doi.org/10.1038/nrd.2016.123	https://dx.doi.org/10.1038/nrd.2016.123	NOUN
admet-1034	189	10	.	.	PUNCT
admet-1034	190	1	[	[	X
admet-1034	190	2	3	3	X
admet-1034	190	3	]	]	X
admet-1034	190	4	s.	s.	PROPN
admet-1034	190	5	saeidnia	saeidnia	PROPN
admet-1034	190	6	,	,	PUNCT
admet-1034	190	7	a.	a.	NOUN
admet-1034	190	8	manayi	manayi	NOUN
admet-1034	190	9	,	,	PUNCT
admet-1034	190	10	m.	m.	NOUN
admet-1034	190	11	abdollahi	abdollahi	PROPN
admet-1034	190	12	.	.	PUNCT
admet-1034	191	1	from	from	ADP
admet-1034	191	2	in	in	ADP
admet-1034	191	3	vitro	vitro	X
admet-1034	191	4	experiments	experiment	NOUN
admet-1034	191	5	to	to	ADP
admet-1034	191	6	in	in	ADP
admet-1034	191	7	vivo	vivo	ADJ
admet-1034	191	8	and	and	CCONJ
admet-1034	191	9	clinical	clinical	ADJ
admet-1034	191	10	studies	study	NOUN
admet-1034	191	11	;	;	PUNCT
admet-1034	191	12	pros	pro	NOUN
admet-1034	191	13	and	and	CCONJ
admet-1034	191	14	cons	con	NOUN
admet-1034	191	15	.	.	PUNCT
admet-1034	192	1	curr	curr	PROPN
admet-1034	192	2	.	.	PUNCT
admet-1034	192	3	drug	drug	NOUN
admet-1034	192	4	discov	discov	PROPN
admet-1034	192	5	.	.	PUNCT
admet-1034	193	1	technol	technol	NOUN
admet-1034	193	2	.	.	PROPN
admet-1034	194	1	12	12	NUM
admet-1034	194	2	(	(	PUNCT
admet-1034	194	3	2015	2015	NUM
admet-1034	194	4	)	)	PUNCT
admet-1034	194	5	218	218	NUM
admet-1034	194	6	-	-	SYM
admet-1034	194	7	224	224	NUM
admet-1034	194	8	.	.	PUNCT
admet-1034	195	1	https://dx.doi.org/10.2174/1570163813666160114093140	https://dx.doi.org/10.2174/1570163813666160114093140	PROPN
admet-1034	195	2	.	.	PUNCT
admet-1034	196	1	[	[	X
admet-1034	196	2	4	4	NUM
admet-1034	196	3	]	]	X
admet-1034	196	4	i.	i.	NOUN
admet-1034	196	5	zeiadeh	zeiadeh	PROPN
admet-1034	196	6	,	,	PUNCT
admet-1034	196	7	a.	a.	PROPN
admet-1034	196	8	najjar	najjar	PROPN
admet-1034	196	9	,	,	PUNCT
admet-1034	196	10	r.	r.	PROPN
admet-1034	196	11	karaman	karaman	PROPN
admet-1034	196	12	.	.	PUNCT
admet-1034	197	1	strategies	strategy	NOUN
admet-1034	197	2	for	for	ADP
admet-1034	197	3	enhancing	enhance	VERB
admet-1034	197	4	the	the	DET
admet-1034	197	5	permeation	permeation	NOUN
admet-1034	197	6	of	of	ADP
admet-1034	197	7	cns	cns	NOUN
admet-1034	197	8	-	-	PUNCT
admet-1034	197	9	active	active	ADJ
admet-1034	197	10	drugs	drug	NOUN
admet-1034	197	11	through	through	ADP
admet-1034	197	12	the	the	DET
admet-1034	197	13	blood	blood	NOUN
admet-1034	197	14	-	-	PUNCT
admet-1034	197	15	brain	brain	NOUN
admet-1034	197	16	barrier	barrier	NOUN
admet-1034	197	17	:	:	PUNCT
admet-1034	197	18	a	a	DET
admet-1034	197	19	review	review	NOUN
admet-1034	197	20	.	.	PUNCT
admet-1034	198	1	molecules	molecule	NOUN
admet-1034	198	2	23	23	NUM
admet-1034	198	3	(	(	PUNCT
admet-1034	198	4	2018	2018	NUM
admet-1034	198	5	)	)	PUNCT
admet-1034	198	6	1289	1289	NUM
admet-1034	198	7	.	.	PUNCT
admet-1034	199	1	https://dx.doi.org/10.3390/molecules23061289	https://dx.doi.org/10.3390/molecules23061289	PROPN
admet-1034	199	2	.	.	PUNCT
admet-1034	200	1	[	[	X
admet-1034	200	2	5	5	NUM
admet-1034	200	3	]	]	X
admet-1034	200	4	m.m	m.m	PROPN
admet-1034	200	5	.	.	PROPN
admet-1034	200	6	patel	patel	PROPN
admet-1034	200	7	,	,	PUNCT
admet-1034	200	8	b.m	b.m	PROPN
admet-1034	200	9	.	.	PROPN
admet-1034	200	10	patel	patel	PROPN
admet-1034	200	11	.	.	PUNCT
admet-1034	201	1	crossing	cross	VERB
admet-1034	201	2	the	the	DET
admet-1034	201	3	blood	blood	NOUN
admet-1034	201	4	-	-	PUNCT
admet-1034	201	5	brain	brain	NOUN
admet-1034	201	6	barrier	barrier	NOUN
admet-1034	201	7	:	:	PUNCT
admet-1034	201	8	recent	recent	ADJ
admet-1034	201	9	advances	advance	NOUN
admet-1034	201	10	in	in	ADP
admet-1034	201	11	drug	drug	NOUN
admet-1034	201	12	delivery	delivery	NOUN
admet-1034	201	13	to	to	ADP
admet-1034	201	14	the	the	DET
admet-1034	201	15	brain	brain	NOUN
admet-1034	201	16	.	.	PUNCT
admet-1034	202	1	cns	cns	NOUN
admet-1034	202	2	drugs	drug	NOUN
admet-1034	202	3	31	31	NUM
admet-1034	202	4	(	(	PUNCT
admet-1034	202	5	2017	2017	NUM
admet-1034	202	6	)	)	PUNCT
admet-1034	202	7	109	109	NUM
admet-1034	202	8	-	-	SYM
admet-1034	202	9	133	133	NUM
admet-1034	202	10	.	.	PUNCT
admet-1034	202	11	https://dx.doi.org/10.1007/s40263-016-0405-9	https://dx.doi.org/10.1007/s40263-016-0405-9	X
admet-1034	202	12	.	.	PUNCT
admet-1034	203	1	https://dx.doi.org/10.1021/cc700187	https://dx.doi.org/10.1021/cc700187	PROPN
admet-1034	203	2	t	t	PROPN
admet-1034	203	3	https://dx.doi.org/10.1038/nrd.2016.123	https://dx.doi.org/10.1038/nrd.2016.123	VERB
admet-1034	203	4	https://dx.doi.org/10.2174/1570163813666160114093140	https://dx.doi.org/10.2174/1570163813666160114093140	PROPN
admet-1034	203	5	https://dx.doi.org/10.2174/1570163813666160114093140	https://dx.doi.org/10.2174/1570163813666160114093140	PROPN
admet-1034	203	6	https://dx.doi.org/10.3390/molecules23061289	https://dx.doi.org/10.3390/molecules23061289	PROPN
admet-1034	203	7	https://dx.doi.org/10.3390/molecules23061289	https://dx.doi.org/10.3390/molecules23061289	PROPN
admet-1034	203	8	https://dx.doi.org/10.1007/s40263-016-0405-9	https://dx.doi.org/10.1007/s40263-016-0405-9	X
admet-1034	204	1	admet	admet	PROPN
admet-1034	204	2	&	&	CCONJ
admet-1034	204	3	dmpk	dmpk	PROPN
admet-1034	204	4	9(4	9(4	PROPN
admet-1034	204	5	)	)	PUNCT
admet-1034	204	6	(	(	PUNCT
admet-1034	204	7	2021	2021	NUM
admet-1034	204	8	)	)	PUNCT
admet-1034	204	9	267	267	NUM
admet-1034	204	10	-	-	SYM
admet-1034	204	11	281	281	NUM
admet-1034	204	12	bbb	bbb	PROPN
admet-1034	204	13	passage	passage	NOUN
admet-1034	204	14	based	base	VERB
admet-1034	204	15	on	on	ADP
admet-1034	204	16	in	in	ADP
admet-1034	204	17	silico	silico	NOUN
admet-1034	204	18	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	204	19	doi	doi	NOUN
admet-1034	204	20	:	:	PUNCT
admet-1034	204	21	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	204	22	279	279	NUM
admet-1034	204	23	[	[	SYM
admet-1034	204	24	6	6	NUM
admet-1034	204	25	]	]	PUNCT
admet-1034	204	26	x.	x.	NOUN
admet-1034	204	27	dong	dong	PROPN
admet-1034	204	28	.	.	PUNCT
admet-1034	205	1	current	current	ADJ
admet-1034	205	2	strategies	strategy	NOUN
admet-1034	205	3	for	for	ADP
admet-1034	205	4	brain	brain	NOUN
admet-1034	205	5	drug	drug	NOUN
admet-1034	205	6	delivery	delivery	NOUN
admet-1034	205	7	.	.	PUNCT
admet-1034	206	1	theranostics	theranostic	VERB
admet-1034	206	2	8	8	NUM
admet-1034	206	3	(	(	PUNCT
admet-1034	206	4	2018	2018	NUM
admet-1034	206	5	)	)	PUNCT
admet-1034	206	6	1481	1481	NUM
admet-1034	206	7	-	-	SYM
admet-1034	206	8	1493	1493	NUM
admet-1034	206	9	.	.	PUNCT
admet-1034	206	10	https://dx.doi.org/10.7150/thno.21254	https://dx.doi.org/10.7150/thno.21254	X
admet-1034	206	11	.	.	PUNCT
admet-1034	207	1	[	[	X
admet-1034	207	2	7	7	X
admet-1034	207	3	]	]	X
admet-1034	207	4	m.	m.	NOUN
admet-1034	207	5	heymans	heyman	NOUN
admet-1034	207	6	,	,	PUNCT
admet-1034	207	7	e.	e.	PROPN
admet-1034	207	8	sevin	sevin	PROPN
admet-1034	207	9	,	,	PUNCT
admet-1034	207	10	f.	f.	PROPN
admet-1034	207	11	gosselet	gosselet	PROPN
admet-1034	207	12	,	,	PUNCT
admet-1034	207	13	s.	s.	PROPN
admet-1034	207	14	lundquist	lundquist	PROPN
admet-1034	207	15	,	,	PUNCT
admet-1034	207	16	m.	m.	PROPN
admet-1034	207	17	culot	culot	PROPN
admet-1034	207	18	.	.	PUNCT
admet-1034	208	1	mimicking	mimic	VERB
admet-1034	208	2	brain	brain	NOUN
admet-1034	208	3	tissue	tissue	NOUN
admet-1034	208	4	binding	bind	VERB
admet-1034	208	5	in	in	ADP
admet-1034	208	6	an	an	DET
admet-1034	208	7	in	in	X
admet-1034	208	8	vitro	vitro	X
admet-1034	208	9	model	model	NOUN
admet-1034	208	10	of	of	ADP
admet-1034	208	11	the	the	DET
admet-1034	208	12	blood	blood	NOUN
admet-1034	208	13	-	-	PUNCT
admet-1034	208	14	brain	brain	NOUN
admet-1034	208	15	barrier	barrier	NOUN
admet-1034	208	16	illustrates	illustrate	VERB
admet-1034	208	17	differences	difference	NOUN
admet-1034	208	18	between	between	ADP
admet-1034	208	19	in	in	ADP
admet-1034	208	20	vitro	vitro	X
admet-1034	208	21	and	and	CCONJ
admet-1034	208	22	in	in	ADP
admet-1034	208	23	vivo	vivo	ADJ
admet-1034	208	24	methods	method	NOUN
admet-1034	208	25	for	for	ADP
admet-1034	208	26	assessing	assess	VERB
admet-1034	208	27	the	the	DET
admet-1034	208	28	rate	rate	NOUN
admet-1034	208	29	of	of	ADP
admet-1034	208	30	brain	brain	NOUN
admet-1034	208	31	penetration	penetration	NOUN
admet-1034	208	32	.	.	PUNCT
admet-1034	209	1	eur	eur	PROPN
admet-1034	209	2	.	.	PUNCT
admet-1034	210	1	j.	j.	PROPN
admet-1034	210	2	pharm	pharm	PROPN
admet-1034	210	3	.	.	PUNCT
admet-1034	211	1	biopharm	biopharm	PROPN
admet-1034	211	2	.	.	PUNCT
admet-1034	212	1	127	127	NUM
admet-1034	212	2	(	(	PUNCT
admet-1034	212	3	2018	2018	NUM
admet-1034	212	4	)	)	PUNCT
admet-1034	212	5	453	453	NUM
admet-1034	212	6	-	-	SYM
admet-1034	212	7	461	461	NUM
admet-1034	212	8	.	.	PUNCT
admet-1034	213	1	https://dx.doi.org/10.1016/j.ejpb.2018.03.007	https://dx.doi.org/10.1016/j.ejpb.2018.03.007	PROPN
admet-1034	213	2	.	.	PUNCT
admet-1034	214	1	[	[	X
admet-1034	214	2	8	8	NUM
admet-1034	214	3	]	]	X
admet-1034	214	4	m.	m.	NOUN
admet-1034	214	5	chrysanthakopoulos	chrysanthakopoulo	NOUN
admet-1034	214	6	,	,	PUNCT
admet-1034	214	7	f.	f.	PROPN
admet-1034	214	8	tsopelas	tsopelas	PROPN
admet-1034	214	9	,	,	PUNCT
admet-1034	214	10	a.	a.	NOUN
admet-1034	214	11	tsantili	tsantili	NOUN
admet-1034	214	12	-	-	PUNCT
admet-1034	214	13	kakoulidou	kakoulidou	NOUN
admet-1034	214	14	.	.	PUNCT
admet-1034	215	1	biomimetic	biomimetic	ADJ
admet-1034	215	2	chromatography	chromatography	NOUN
admet-1034	215	3	:	:	PUNCT
admet-1034	215	4	a	a	DET
admet-1034	215	5	useful	useful	ADJ
admet-1034	215	6	tool	tool	NOUN
admet-1034	215	7	in	in	ADP
admet-1034	215	8	the	the	DET
admet-1034	215	9	drug	drug	NOUN
admet-1034	215	10	discovery	discovery	NOUN
admet-1034	215	11	process	process	NOUN
admet-1034	215	12	.	.	PUNCT
admet-1034	216	1	adv	adv	PROPN
admet-1034	216	2	.	.	PUNCT
admet-1034	216	3	chromatogr	chromatogr	PROPN
admet-1034	216	4	.	.	PUNCT
admet-1034	217	1	51	51	NUM
admet-1034	217	2	(	(	PUNCT
admet-1034	217	3	2014	2014	NUM
admet-1034	217	4	)	)	PUNCT
admet-1034	217	5	91	91	NUM
admet-1034	217	6	-	-	SYM
admet-1034	217	7	125	125	NUM
admet-1034	217	8	.	.	PUNCT
admet-1034	218	1	[	[	X
admet-1034	218	2	9	9	NUM
admet-1034	218	3	]	]	X
admet-1034	218	4	g.	g.	PROPN
admet-1034	218	5	russo	russo	PROPN
admet-1034	218	6	,	,	PUNCT
admet-1034	218	7	g.	g.	PROPN
admet-1034	218	8	ermondi	ermondi	PROPN
admet-1034	218	9	,	,	PUNCT
admet-1034	218	10	g.	g.	PROPN
admet-1034	218	11	caron	caron	PROPN
admet-1034	218	12	,	,	PUNCT
admet-1034	218	13	d.	d.	PROPN
admet-1034	218	14	verzele	verzele	PROPN
admet-1034	218	15	,	,	PUNCT
admet-1034	218	16	f.	f.	PROPN
admet-1034	218	17	lynen	lynen	PROPN
admet-1034	218	18	.	.	PUNCT
admet-1034	219	1	into	into	ADP
admet-1034	219	2	the	the	DET
admet-1034	219	3	first	first	ADJ
admet-1034	219	4	biomimetic	biomimetic	ADJ
admet-1034	219	5	sphingomyelin	sphingomyelin	NOUN
admet-1034	219	6	stationary	stationary	ADJ
admet-1034	219	7	phase	phase	NOUN
admet-1034	219	8	:	:	PUNCT
admet-1034	219	9	suitability	suitability	NOUN
admet-1034	219	10	in	in	ADP
admet-1034	219	11	drugs	drug	NOUN
admet-1034	219	12	'	'	PART
admet-1034	219	13	biopharmaceutic	biopharmaceutic	ADJ
admet-1034	219	14	profiling	profiling	NOUN
admet-1034	219	15	and	and	CCONJ
admet-1034	219	16	block	block	NOUN
admet-1034	219	17	relevance	relevance	NOUN
admet-1034	219	18	analysis	analysis	NOUN
admet-1034	219	19	of	of	ADP
admet-1034	219	20	selectivity	selectivity	NOUN
admet-1034	219	21	.	.	PUNCT
admet-1034	220	1	eur	eur	PROPN
admet-1034	220	2	.	.	PUNCT
admet-1034	221	1	j.	j.	PROPN
admet-1034	221	2	pharm	pharm	PROPN
admet-1034	221	3	.	.	PUNCT
admet-1034	222	1	sci	sci	PROPN
admet-1034	222	2	.	.	PROPN
admet-1034	223	1	156	156	NUM
admet-1034	223	2	(	(	PUNCT
admet-1034	223	3	2021	2021	NUM
admet-1034	223	4	)	)	PUNCT
admet-1034	223	5	105585	105585	NUM
admet-1034	223	6	.	.	PUNCT
admet-1034	224	1	https://dx.doi.org/10.1016/j.ejps.2020.105585	https://dx.doi.org/10.1016/j.ejps.2020.105585	X
admet-1034	224	2	.	.	PUNCT
admet-1034	225	1	[	[	X
admet-1034	225	2	10	10	NUM
admet-1034	225	3	]	]	X
admet-1034	225	4	c.	c.	PROPN
admet-1034	225	5	stergiopoulos	stergiopoulos	PROPN
admet-1034	225	6	,	,	PUNCT
admet-1034	225	7	f.	f.	PROPN
admet-1034	225	8	tsopelas	tsopelas	PROPN
admet-1034	225	9	,	,	PUNCT
admet-1034	225	10	k.	k.	PROPN
admet-1034	225	11	valko	valko	PROPN
admet-1034	225	12	.	.	PUNCT
admet-1034	226	1	prediction	prediction	NOUN
admet-1034	226	2	of	of	ADP
admet-1034	226	3	herg	herg	PROPN
admet-1034	226	4	inhibition	inhibition	NOUN
admet-1034	226	5	of	of	ADP
admet-1034	226	6	drug	drug	NOUN
admet-1034	226	7	discovery	discovery	NOUN
admet-1034	226	8	compounds	compound	NOUN
admet-1034	226	9	using	use	VERB
admet-1034	226	10	biomimetic	biomimetic	ADJ
admet-1034	226	11	hplc	hplc	NOUN
admet-1034	226	12	measurements	measurement	NOUN
admet-1034	226	13	.	.	PUNCT
admet-1034	227	1	admet	admet	PROPN
admet-1034	227	2	and	and	CCONJ
admet-1034	227	3	dmpk	dmpk	X
admet-1034	227	4	9	9	NUM
admet-1034	227	5	(	(	PUNCT
admet-1034	227	6	2021	2021	NUM
admet-1034	227	7	)	)	PUNCT
admet-1034	227	8	191	191	NUM
admet-1034	227	9	-	-	SYM
admet-1034	227	10	207	207	NUM
admet-1034	227	11	.	.	PUNCT
admet-1034	228	1	https://doi.org/10.5599/admet.995	https://doi.org/10.5599/admet.995	NOUN
admet-1034	228	2	.	.	PUNCT
admet-1034	229	1	[	[	X
admet-1034	229	2	11	11	NUM
admet-1034	229	3	]	]	X
admet-1034	229	4	k.l	k.l	PROPN
admet-1034	229	5	.	.	PROPN
admet-1034	229	6	valko	valko	PROPN
admet-1034	229	7	,	,	PUNCT
admet-1034	229	8	t.	t.	PROPN
admet-1034	229	9	zhang	zhang	PROPN
admet-1034	229	10	.	.	PUNCT
admet-1034	230	1	biomimetic	biomimetic	ADJ
admet-1034	230	2	properties	property	NOUN
admet-1034	230	3	and	and	CCONJ
admet-1034	230	4	estimated	estimate	VERB
admet-1034	230	5	in	in	ADP
admet-1034	230	6	vivo	vivo	ADJ
admet-1034	230	7	distribution	distribution	NOUN
admet-1034	230	8	of	of	ADP
admet-1034	230	9	chloroquine	chloroquine	NOUN
admet-1034	230	10	and	and	CCONJ
admet-1034	230	11	hydroxy	hydroxy	PROPN
admet-1034	230	12	-	-	PUNCT
admet-1034	230	13	chloroquine	chloroquine	NOUN
admet-1034	230	14	enantiomers	enantiomer	NOUN
admet-1034	230	15	.	.	PUNCT
admet-1034	231	1	admet	admet	PROPN
admet-1034	231	2	and	and	CCONJ
admet-1034	231	3	dmpk	dmpk	X
admet-1034	231	4	9	9	NUM
admet-1034	231	5	(	(	PUNCT
admet-1034	231	6	2021	2021	NUM
admet-1034	231	7	)	)	PUNCT
admet-1034	231	8	151	151	NUM
admet-1034	231	9	-	-	SYM
admet-1034	231	10	165	165	NUM
admet-1034	231	11	.	.	PUNCT
admet-1034	232	1	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-1034	232	2	.	.	PUNCT
admet-1034	233	1	[	[	X
admet-1034	233	2	12	12	NUM
admet-1034	233	3	]	]	X
admet-1034	233	4	f.	f.	PROPN
admet-1034	233	5	tsopelas	tsopelas	PROPN
admet-1034	233	6	,	,	PUNCT
admet-1034	233	7	t.	t.	PROPN
admet-1034	233	8	vallianatou	vallianatou	PROPN
admet-1034	233	9	,	,	PUNCT
admet-1034	233	10	a.	a.	NOUN
admet-1034	233	11	tsantili	tsantili	NOUN
admet-1034	233	12	-	-	PUNCT
admet-1034	233	13	kakoulidou	kakoulidou	NOUN
admet-1034	233	14	.	.	PUNCT
admet-1034	233	15	advances	advance	NOUN
admet-1034	233	16	in	in	ADP
admet-1034	233	17	immobilized	immobilized	ADJ
admet-1034	233	18	artificial	artificial	ADJ
admet-1034	233	19	membrane	membrane	NOUN
admet-1034	233	20	(	(	PUNCT
admet-1034	233	21	iam	iam	PROPN
admet-1034	233	22	)	)	PUNCT
admet-1034	233	23	chromatography	chromatography	NOUN
admet-1034	233	24	for	for	ADP
admet-1034	233	25	novel	novel	ADJ
admet-1034	233	26	drug	drug	NOUN
admet-1034	233	27	discovery	discovery	NOUN
admet-1034	233	28	.	.	PUNCT
admet-1034	234	1	expert	expert	NOUN
admet-1034	234	2	opin	opin	NOUN
admet-1034	234	3	.	.	PUNCT
admet-1034	235	1	drug	drug	NOUN
admet-1034	235	2	discov	discov	NOUN
admet-1034	235	3	.	.	PUNCT
admet-1034	236	1	11	11	NUM
admet-1034	236	2	(	(	PUNCT
admet-1034	236	3	2016	2016	NUM
admet-1034	236	4	)	)	PUNCT
admet-1034	236	5	473	473	NUM
admet-1034	236	6	-	-	SYM
admet-1034	236	7	488	488	NUM
admet-1034	236	8	.	.	PUNCT
admet-1034	237	1	https://dx.doi.org/10.1517/17460441.2016.1160886	https://dx.doi.org/10.1517/17460441.2016.1160886	X
admet-1034	237	2	.	.	PUNCT
admet-1034	238	1	[	[	X
admet-1034	238	2	13	13	NUM
admet-1034	238	3	]	]	X
admet-1034	238	4	g.	g.	PROPN
admet-1034	238	5	russo	russo	PROPN
admet-1034	238	6	,	,	PUNCT
admet-1034	238	7	l.	l.	PROPN
admet-1034	238	8	grumetto	grumetto	PROPN
admet-1034	238	9	,	,	PUNCT
admet-1034	238	10	r.	r.	PROPN
admet-1034	238	11	szucs	szucs	PROPN
admet-1034	238	12	,	,	PUNCT
admet-1034	238	13	f.	f.	PROPN
admet-1034	238	14	barbato	barbato	PROPN
admet-1034	238	15	,	,	PUNCT
admet-1034	238	16	f.	f.	PROPN
admet-1034	238	17	lynen	lynen	PROPN
admet-1034	238	18	.	.	PUNCT
admet-1034	239	1	screening	screen	VERB
admet-1034	239	2	therapeutics	therapeutic	NOUN
admet-1034	239	3	according	accord	VERB
admet-1034	239	4	to	to	ADP
admet-1034	239	5	their	their	PRON
admet-1034	239	6	uptake	uptake	NOUN
admet-1034	239	7	across	across	ADP
admet-1034	239	8	the	the	DET
admet-1034	239	9	blood	blood	NOUN
admet-1034	239	10	-	-	PUNCT
admet-1034	239	11	brain	brain	NOUN
admet-1034	239	12	barrier	barrier	NOUN
admet-1034	239	13	:	:	PUNCT
admet-1034	239	14	a	a	DET
admet-1034	239	15	high	high	ADJ
admet-1034	239	16	throughput	throughput	NOUN
admet-1034	239	17	method	method	NOUN
admet-1034	239	18	based	base	VERB
admet-1034	239	19	on	on	ADP
admet-1034	239	20	immobilized	immobilized	ADJ
admet-1034	239	21	artificial	artificial	ADJ
admet-1034	239	22	membrane	membrane	NOUN
admet-1034	239	23	liquid	liquid	ADJ
admet-1034	239	24	chromatography	chromatography	NOUN
admet-1034	239	25	-	-	PUNCT
admet-1034	239	26	diode	diode	NOUN
admet-1034	239	27	-	-	PUNCT
admet-1034	239	28	array	array	NOUN
admet-1034	239	29	-	-	PUNCT
admet-1034	239	30	detection	detection	NOUN
admet-1034	239	31	coupled	couple	VERB
admet-1034	239	32	to	to	PART
admet-1034	239	33	electrospray	electrospray	VERB
admet-1034	239	34	-	-	PUNCT
admet-1034	239	35	time	time	NOUN
admet-1034	239	36	-	-	PUNCT
admet-1034	239	37	of	of	ADP
admet-1034	239	38	-	-	PUNCT
admet-1034	239	39	flight	flight	NOUN
admet-1034	239	40	mass	mass	NOUN
admet-1034	239	41	spectrometry	spectrometry	NOUN
admet-1034	239	42	.	.	PUNCT
admet-1034	240	1	eur	eur	PROPN
admet-1034	240	2	.	.	PUNCT
admet-1034	241	1	j.	j.	PROPN
admet-1034	241	2	pharm	pharm	PROPN
admet-1034	241	3	.	.	PUNCT
admet-1034	242	1	biopharm	biopharm	PROPN
admet-1034	242	2	.	.	PUNCT
admet-1034	243	1	127	127	NUM
admet-1034	243	2	(	(	PUNCT
admet-1034	243	3	2018	2018	NUM
admet-1034	243	4	)	)	PUNCT
admet-1034	243	5	72	72	NUM
admet-1034	243	6	-	-	SYM
admet-1034	243	7	84	84	NUM
admet-1034	243	8	.	.	PUNCT
admet-1034	244	1	https://dx.doi.org/10.1016/j.ejpb.2018.02.004	https://dx.doi.org/10.1016/j.ejpb.2018.02.004	PROPN
admet-1034	244	2	.	.	PUNCT
admet-1034	245	1	[	[	X
admet-1034	245	2	14	14	NUM
admet-1034	245	3	]	]	X
admet-1034	245	4	l.	l.	PROPN
admet-1034	245	5	grumetto	grumetto	PROPN
admet-1034	245	6	,	,	PUNCT
admet-1034	245	7	c.	c.	PROPN
admet-1034	245	8	carpentiero	carpentiero	PROPN
admet-1034	245	9	,	,	PUNCT
admet-1034	245	10	f.	f.	PROPN
admet-1034	245	11	barbato	barbato	PROPN
admet-1034	245	12	.	.	PUNCT
admet-1034	246	1	lipophilic	lipophilic	ADJ
admet-1034	246	2	and	and	CCONJ
admet-1034	246	3	electrostatic	electrostatic	ADJ
admet-1034	246	4	forces	force	NOUN
admet-1034	246	5	encoded	encode	VERB
admet-1034	246	6	in	in	ADP
admet-1034	246	7	iam	iam	PROPN
admet-1034	246	8	-	-	PUNCT
admet-1034	246	9	hplc	hplc	NOUN
admet-1034	246	10	indexes	index	NOUN
admet-1034	246	11	of	of	ADP
admet-1034	246	12	basic	basic	ADJ
admet-1034	246	13	drugs	drug	NOUN
admet-1034	246	14	:	:	PUNCT
admet-1034	246	15	their	their	PRON
admet-1034	246	16	role	role	NOUN
admet-1034	246	17	in	in	ADP
admet-1034	246	18	membrane	membrane	NOUN
admet-1034	246	19	partition	partition	NOUN
admet-1034	246	20	and	and	CCONJ
admet-1034	246	21	their	their	PRON
admet-1034	246	22	relationships	relationship	NOUN
admet-1034	246	23	with	with	ADP
admet-1034	246	24	bbb	bbb	PROPN
admet-1034	246	25	passage	passage	NOUN
admet-1034	246	26	data	datum	NOUN
admet-1034	246	27	.	.	PUNCT
admet-1034	247	1	eur	eur	PROPN
admet-1034	247	2	.	.	PUNCT
admet-1034	248	1	j.	j.	PROPN
admet-1034	248	2	pharm	pharm	PROPN
admet-1034	248	3	.	.	PUNCT
admet-1034	249	1	sci	sci	PROPN
admet-1034	249	2	.	.	PROPN
admet-1034	250	1	45	45	NUM
admet-1034	250	2	(	(	PUNCT
admet-1034	250	3	2012	2012	NUM
admet-1034	250	4	)	)	PUNCT
admet-1034	250	5	685	685	NUM
admet-1034	250	6	-	-	SYM
admet-1034	250	7	692	692	NUM
admet-1034	250	8	.	.	PUNCT
admet-1034	251	1	https://dx.doi.org/10.1016/j.ejps.2012.01.008	https://dx.doi.org/10.1016/j.ejps.2012.01.008	NOUN
admet-1034	251	2	.	.	PUNCT
admet-1034	252	1	[	[	X
admet-1034	252	2	15	15	NUM
admet-1034	252	3	]	]	X
admet-1034	252	4	l.	l.	PROPN
admet-1034	252	5	grumetto	grumetto	PROPN
admet-1034	252	6	,	,	PUNCT
admet-1034	252	7	c.	c.	PROPN
admet-1034	252	8	carpentiero	carpentiero	PROPN
admet-1034	252	9	,	,	PUNCT
admet-1034	252	10	p.	p.	NOUN
admet-1034	252	11	di	di	NOUN
admet-1034	252	12	vaio	vaio	PROPN
admet-1034	252	13	,	,	PUNCT
admet-1034	252	14	f.	f.	PROPN
admet-1034	252	15	frecentese	frecentese	PROPN
admet-1034	252	16	,	,	PUNCT
admet-1034	252	17	f.	f.	PROPN
admet-1034	252	18	barbato	barbato	PROPN
admet-1034	252	19	.	.	PUNCT
admet-1034	253	1	lipophilic	lipophilic	ADJ
admet-1034	253	2	and	and	CCONJ
admet-1034	253	3	polar	polar	ADJ
admet-1034	253	4	interaction	interaction	NOUN
admet-1034	253	5	forces	force	NOUN
admet-1034	253	6	between	between	ADP
admet-1034	253	7	acidic	acidic	ADJ
admet-1034	253	8	drugs	drug	NOUN
admet-1034	253	9	and	and	CCONJ
admet-1034	253	10	membrane	membrane	NOUN
admet-1034	253	11	phospholipids	phospholipid	NOUN
admet-1034	253	12	encoded	encode	VERB
admet-1034	253	13	in	in	ADP
admet-1034	253	14	iam	iam	PROPN
admet-1034	253	15	-	-	PUNCT
admet-1034	253	16	hplc	hplc	NOUN
admet-1034	253	17	indexes	index	NOUN
admet-1034	253	18	:	:	PUNCT
admet-1034	253	19	their	their	PRON
admet-1034	253	20	role	role	NOUN
admet-1034	253	21	in	in	ADP
admet-1034	253	22	membrane	membrane	NOUN
admet-1034	253	23	partition	partition	NOUN
admet-1034	253	24	and	and	CCONJ
admet-1034	253	25	relationships	relationship	NOUN
admet-1034	253	26	with	with	ADP
admet-1034	253	27	bbb	bbb	PROPN
admet-1034	253	28	permeation	permeation	NOUN
admet-1034	253	29	data	data	PROPN
admet-1034	253	30	.	.	PUNCT
admet-1034	254	1	j.	j.	PROPN
admet-1034	254	2	pharm	pharm	PROPN
admet-1034	254	3	.	.	PUNCT
admet-1034	254	4	biomed	biome	VERB
admet-1034	254	5	.	.	PUNCT
admet-1034	255	1	anal	anal	ADJ
admet-1034	255	2	.	.	PUNCT
admet-1034	256	1	75	75	NUM
admet-1034	256	2	(	(	PUNCT
admet-1034	256	3	2013	2013	NUM
admet-1034	256	4	)	)	PUNCT
admet-1034	256	5	165	165	NUM
admet-1034	256	6	-	-	SYM
admet-1034	256	7	172	172	NUM
admet-1034	256	8	,	,	PUNCT
admet-1034	256	9	https://dx.doi.org/10.1016/j.jpba.2012.11.034	https://dx.doi.org/10.1016/j.jpba.2012.11.034	PROPN
admet-1034	256	10	.	.	PUNCT
admet-1034	257	1	[	[	X
admet-1034	257	2	16	16	NUM
admet-1034	257	3	]	]	X
admet-1034	257	4	l.	l.	PROPN
admet-1034	257	5	grumetto	grumetto	PROPN
admet-1034	257	6	,	,	PUNCT
admet-1034	257	7	g.	g.	PROPN
admet-1034	257	8	russo	russo	PROPN
admet-1034	257	9	,	,	PUNCT
admet-1034	257	10	f.	f.	PROPN
admet-1034	257	11	barbato	barbato	PROPN
admet-1034	257	12	.	.	PUNCT
admet-1034	258	1	indexes	index	NOUN
admet-1034	258	2	of	of	ADP
admet-1034	258	3	polar	polar	ADJ
admet-1034	258	4	interactions	interaction	NOUN
admet-1034	258	5	between	between	ADP
admet-1034	258	6	ionizable	ionizable	ADJ
admet-1034	258	7	drugs	drug	NOUN
admet-1034	258	8	and	and	CCONJ
admet-1034	258	9	membrane	membrane	NOUN
admet-1034	258	10	phospholipids	phospholipid	NOUN
admet-1034	258	11	measured	measure	VERB
admet-1034	258	12	by	by	ADP
admet-1034	258	13	iam	iam	PROPN
admet-1034	258	14	-	-	PUNCT
admet-1034	258	15	hplc	hplc	PROPN
admet-1034	258	16	:	:	PUNCT
admet-1034	258	17	their	their	PRON
admet-1034	258	18	relationships	relationship	NOUN
admet-1034	258	19	with	with	ADP
admet-1034	258	20	data	datum	NOUN
admet-1034	258	21	of	of	ADP
admet-1034	258	22	blood	blood	NOUN
admet-1034	258	23	-	-	PUNCT
admet-1034	258	24	brain	brain	NOUN
admet-1034	258	25	barrier	barrier	NOUN
admet-1034	258	26	passage	passage	NOUN
admet-1034	258	27	.	.	PUNCT
admet-1034	259	1	eur	eur	PROPN
admet-1034	259	2	j	j	PROPN
admet-1034	259	3	pharm	pharm	PROPN
admet-1034	259	4	sci	sci	PROPN
admet-1034	259	5	65	65	NUM
admet-1034	259	6	(	(	PUNCT
admet-1034	259	7	2014	2014	NUM
admet-1034	259	8	)	)	PUNCT
admet-1034	259	9	139	139	NUM
admet-1034	259	10	-	-	SYM
admet-1034	259	11	146	146	NUM
admet-1034	259	12	.	.	PUNCT
admet-1034	260	1	https://dx.doi.org/10.1016/j.ejps.2014.09.015	https://dx.doi.org/10.1016/j.ejps.2014.09.015	PROPN
admet-1034	260	2	.	.	PUNCT
admet-1034	261	1	[	[	X
admet-1034	261	2	17	17	NUM
admet-1034	261	3	]	]	X
admet-1034	261	4	l.	l.	PROPN
admet-1034	261	5	grumetto	grumetto	PROPN
admet-1034	261	6	,	,	PUNCT
admet-1034	261	7	g.	g.	PROPN
admet-1034	261	8	russo	russo	PROPN
admet-1034	261	9	,	,	PUNCT
admet-1034	261	10	f.	f.	PROPN
admet-1034	261	11	barbato	barbato	PROPN
admet-1034	261	12	.	.	PUNCT
admet-1034	262	1	relationships	relationship	NOUN
admet-1034	262	2	between	between	ADP
admet-1034	262	3	human	human	ADJ
admet-1034	262	4	intestinal	intestinal	ADJ
admet-1034	262	5	absorption	absorption	NOUN
admet-1034	262	6	and	and	CCONJ
admet-1034	262	7	polar	polar	ADJ
admet-1034	262	8	interactions	interaction	NOUN
admet-1034	262	9	drug	drug	NOUN
admet-1034	262	10	/	/	SYM
admet-1034	262	11	phospholipids	phospholipid	NOUN
admet-1034	262	12	estimated	estimate	VERB
admet-1034	262	13	by	by	ADP
admet-1034	262	14	iam	iam	PROPN
admet-1034	262	15	-	-	PUNCT
admet-1034	262	16	hplc	hplc	PROPN
admet-1034	262	17	.	.	PUNCT
admet-1034	263	1	int	int	NOUN
admet-1034	263	2	.	.	PUNCT
admet-1034	264	1	j.	j.	PROPN
admet-1034	264	2	pharm	pharm	PROPN
admet-1034	264	3	.	.	PUNCT
admet-1034	265	1	489	489	NUM
admet-1034	265	2	(	(	PUNCT
admet-1034	265	3	2015	2015	NUM
admet-1034	265	4	)	)	PUNCT
admet-1034	265	5	186	186	NUM
admet-1034	265	6	-	-	SYM
admet-1034	265	7	194	194	NUM
admet-1034	265	8	.	.	PUNCT
admet-1034	266	1	https://dx.doi.org/10.1016/j.ijpharm.2015.04.062	https://dx.doi.org/10.1016/j.ijpharm.2015.04.062	X
admet-1034	266	2	.	.	PUNCT
admet-1034	267	1	[	[	X
admet-1034	267	2	18	18	NUM
admet-1034	267	3	]	]	X
admet-1034	267	4	l.	l.	PROPN
admet-1034	267	5	grumetto	grumetto	PROPN
admet-1034	267	6	,	,	PUNCT
admet-1034	267	7	g.	g.	PROPN
admet-1034	267	8	russo	russo	PROPN
admet-1034	267	9	,	,	PUNCT
admet-1034	267	10	f.	f.	PROPN
admet-1034	267	11	barbato	barbato	PROPN
admet-1034	267	12	.	.	PUNCT
admet-1034	268	1	immobilized	immobilize	VERB
admet-1034	268	2	artificial	artificial	ADJ
admet-1034	268	3	membrane	membrane	NOUN
admet-1034	268	4	hplc	hplc	NOUN
admet-1034	268	5	derived	derive	VERB
admet-1034	268	6	parameters	parameter	NOUN
admet-1034	268	7	vs	vs	ADP
admet-1034	268	8	pampa	pampa	PROPN
admet-1034	268	9	-	-	PUNCT
admet-1034	268	10	bbb	bbb	PROPN
admet-1034	268	11	data	datum	NOUN
admet-1034	268	12	in	in	ADP
admet-1034	268	13	estimating	estimate	VERB
admet-1034	268	14	in	in	ADP
admet-1034	268	15	situ	situ	ADJ
admet-1034	268	16	measured	measure	VERB
admet-1034	268	17	blood	blood	NOUN
admet-1034	268	18	-	-	PUNCT
admet-1034	268	19	brain	brain	NOUN
admet-1034	268	20	barrier	barrier	NOUN
admet-1034	268	21	permeation	permeation	NOUN
admet-1034	268	22	of	of	ADP
admet-1034	268	23	drugs	drug	NOUN
admet-1034	268	24	.	.	PUNCT
admet-1034	269	1	mol	mol	PROPN
admet-1034	269	2	.	.	PUNCT
admet-1034	269	3	pharm	pharm	PROPN
admet-1034	269	4	.	.	PUNCT
admet-1034	270	1	13	13	NUM
admet-1034	270	2	(	(	PUNCT
admet-1034	270	3	2016	2016	NUM
admet-1034	270	4	)	)	PUNCT
admet-1034	270	5	2808	2808	NUM
admet-1034	270	6	-	-	SYM
admet-1034	270	7	2816	2816	NUM
admet-1034	270	8	.	.	PUNCT
admet-1034	271	1	https://dx.doi.org/10.1021/acs.molpharmaceut.6b00397	https://dx.doi.org/10.1021/acs.molpharmaceut.6b00397	PROPN
admet-1034	271	2	.	.	PUNCT
admet-1034	272	1	[	[	X
admet-1034	272	2	19	19	NUM
admet-1034	272	3	]	]	X
admet-1034	272	4	l.	l.	PROPN
admet-1034	272	5	grumetto	grumetto	PROPN
admet-1034	272	6	,	,	PUNCT
admet-1034	272	7	g.	g.	PROPN
admet-1034	272	8	russo	russo	PROPN
admet-1034	272	9	,	,	PUNCT
admet-1034	272	10	f.	f.	PROPN
admet-1034	272	11	barbato	barbato	PROPN
admet-1034	272	12	.	.	PUNCT
admet-1034	273	1	polar	polar	ADJ
admet-1034	273	2	interactions	interaction	NOUN
admet-1034	273	3	drug	drug	NOUN
admet-1034	273	4	/	/	SYM
admet-1034	273	5	phospholipids	phospholipid	NOUN
admet-1034	273	6	estimated	estimate	VERB
admet-1034	273	7	by	by	ADP
admet-1034	273	8	iam	iam	PROPN
admet-1034	273	9	-	-	PUNCT
admet-1034	273	10	hplc	hplc	PROPN
admet-1034	273	11	vs	vs	ADP
admet-1034	273	12	cultured	cultured	ADJ
admet-1034	273	13	cell	cell	NOUN
admet-1034	273	14	line	line	NOUN
admet-1034	273	15	passage	passage	NOUN
admet-1034	273	16	data	datum	NOUN
admet-1034	273	17	:	:	PUNCT
admet-1034	273	18	their	their	PRON
admet-1034	273	19	relationships	relationship	NOUN
admet-1034	273	20	and	and	CCONJ
admet-1034	273	21	comparison	comparison	NOUN
admet-1034	273	22	of	of	ADP
admet-1034	273	23	their	their	PRON
admet-1034	273	24	effectiveness	effectiveness	NOUN
admet-1034	273	25	in	in	ADP
admet-1034	273	26	predicting	predict	VERB
admet-1034	273	27	drug	drug	NOUN
admet-1034	273	28	human	human	ADJ
admet-1034	273	29	intestinal	intestinal	ADJ
admet-1034	273	30	absorption	absorption	NOUN
admet-1034	273	31	.	.	PUNCT
admet-1034	274	1	int	int	NOUN
admet-1034	274	2	.	.	PUNCT
admet-1034	275	1	j.	j.	PROPN
admet-1034	275	2	pharm	pharm	PROPN
admet-1034	275	3	.	.	PUNCT
admet-1034	276	1	500	500	NUM
admet-1034	276	2	(	(	PUNCT
admet-1034	276	3	2016	2016	NUM
admet-1034	276	4	)	)	PUNCT
admet-1034	276	5	275	275	NUM
admet-1034	276	6	-	-	SYM
admet-1034	276	7	290	290	NUM
admet-1034	276	8	.	.	PUNCT
admet-1034	277	1	https://dx.doi.org/10.1016/j.ijpharm.2016.01.019	https://dx.doi.org/10.1016/j.ijpharm.2016.01.019	PROPN
admet-1034	277	2	.	.	PUNCT
admet-1034	278	1	[	[	X
admet-1034	278	2	20	20	NUM
admet-1034	278	3	]	]	PUNCT
admet-1034	278	4	t.	t.	NOUN
admet-1034	278	5	braumann	braumann	PROPN
admet-1034	278	6	,	,	PUNCT
admet-1034	278	7	g.	g.	PROPN
admet-1034	278	8	weber	weber	PROPN
admet-1034	278	9	,	,	PUNCT
admet-1034	278	10	l.h	l.h	PROPN
admet-1034	278	11	.	.	PROPN
admet-1034	278	12	grimme	grimme	PROPN
admet-1034	278	13	.	.	PUNCT
admet-1034	279	1	quantitative	quantitative	ADJ
admet-1034	279	2	structure	structure	NOUN
admet-1034	279	3	—	—	PUNCT
admet-1034	279	4	activity	activity	NOUN
admet-1034	279	5	relationships	relationship	NOUN
admet-1034	279	6	for	for	ADP
admet-1034	279	7	herbicides	herbicide	NOUN
admet-1034	279	8	:	:	PUNCT
admet-1034	279	9	reversed	reverse	VERB
admet-1034	279	10	-	-	PUNCT
admet-1034	279	11	phase	phase	NOUN
admet-1034	279	12	liquid	liquid	ADJ
admet-1034	279	13	chromatographic	chromatographic	ADJ
admet-1034	279	14	retention	retention	NOUN
admet-1034	279	15	parameter	parameter	NOUN
admet-1034	279	16	,	,	PUNCT
admet-1034	279	17	log	log	NOUN
admet-1034	279	18	kw	kw	INTJ
admet-1034	279	19	,	,	PUNCT
admet-1034	279	20	versus	versus	ADP
admet-1034	279	21	liquid	liquid	NOUN
admet-1034	279	22	-	-	PUNCT
admet-1034	279	23	liquid	liquid	ADJ
admet-1034	279	24	partition	partition	NOUN
admet-1034	279	25	coefficient	coefficient	NOUN
admet-1034	279	26	as	as	ADP
admet-1034	279	27	a	a	DET
admet-1034	279	28	model	model	NOUN
admet-1034	279	29	of	of	ADP
admet-1034	279	30	the	the	DET
admet-1034	279	31	hydrophobicity	hydrophobicity	NOUN
admet-1034	279	32	of	of	ADP
admet-1034	279	33	phenylureas	phenylurea	NOUN
admet-1034	279	34	,	,	PUNCT
admet-1034	279	35	s	s	NOUN
admet-1034	279	36	-	-	PUNCT
admet-1034	279	37	triazines	triazine	NOUN
admet-1034	279	38	and	and	CCONJ
admet-1034	279	39	phenoxycarbonic	phenoxycarbonic	ADJ
admet-1034	279	40	acid	acid	NOUN
admet-1034	279	41	derivatives	derivative	NOUN
admet-1034	279	42	.	.	PUNCT
admet-1034	280	1	journal	journal	NOUN
admet-1034	280	2	of	of	ADP
admet-1034	280	3	chromatography	chromatography	NOUN
admet-1034	280	4	a	a	DET
admet-1034	280	5	261	261	NUM
admet-1034	280	6	(	(	PUNCT
admet-1034	280	7	1983	1983	NUM
admet-1034	280	8	)	)	PUNCT
admet-1034	280	9	329	329	NUM
admet-1034	280	10	-	-	SYM
admet-1034	280	11	343	343	NUM
admet-1034	280	12	.	.	PUNCT
admet-1034	281	1	https://doi.org/10.1016/s00219673(01)87961-9	https://doi.org/10.1016/s00219673(01)87961-9	PROPN
admet-1034	281	2	.	.	PUNCT
admet-1034	282	1	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	282	2	https://dx.doi.org/10.7150/thno.21254	https://dx.doi.org/10.7150/thno.21254	PUNCT
admet-1034	282	3	https://dx.doi.org/10.7150/thno.21254	https://dx.doi.org/10.7150/thno.21254	PUNCT
admet-1034	282	4	https://dx.doi.org/10.1016/j.ejpb.2018.03.007	https://dx.doi.org/10.1016/j.ejpb.2018.03.007	PROPN
admet-1034	282	5	https://dx.doi.org/10.1016/j.ejpb.2018.03.007	https://dx.doi.org/10.1016/j.ejpb.2018.03.007	PROPN
admet-1034	282	6	https://dx.doi.org/10.1016/j.ejps.2020.105585	https://dx.doi.org/10.1016/j.ejps.2020.105585	NUM
admet-1034	282	7	https://doi.org/10.5599/admet.995	https://doi.org/10.5599/admet.995	NOUN
admet-1034	282	8	https://doi.org/10.5599/admet.995	https://doi.org/10.5599/admet.995	NOUN
admet-1034	282	9	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	VERB
admet-1034	282	10	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-1034	283	1	https://dx.doi.org/10.1517/17460441.2016.1160886	https://dx.doi.org/10.1517/17460441.2016.1160886	VERB
admet-1034	283	2	https://dx.doi.org/10.1016/j.ejpb.2018.02.004	https://dx.doi.org/10.1016/j.ejpb.2018.02.004	PROPN
admet-1034	283	3	https://dx.doi.org/10.1016/j.ejpb.2018.02.004	https://dx.doi.org/10.1016/j.ejpb.2018.02.004	PROPN
admet-1034	283	4	https://dx.doi.org/10.1016/j.ejps.2012.01.008	https://dx.doi.org/10.1016/j.ejps.2012.01.008	NOUN
admet-1034	283	5	https://dx.doi.org/10.1016/j.jpba.2012.11.034	https://dx.doi.org/10.1016/j.jpba.2012.11.034	PROPN
admet-1034	283	6	https://dx.doi.org/10.1016/j.ejps.2014.09.015	https://dx.doi.org/10.1016/j.ejps.2014.09.015	PROPN
admet-1034	283	7	https://dx.doi.org/10.1016/j.ijpharm.2015.04.062	https://dx.doi.org/10.1016/j.ijpharm.2015.04.062	PROPN
admet-1034	283	8	https://dx.doi.org/10.1021/acs.molpharmaceut.6b00397	https://dx.doi.org/10.1021/acs.molpharmaceut.6b00397	VERB
admet-1034	283	9	https://dx.doi.org/10.1016/j.ijpharm.2016.01.019	https://dx.doi.org/10.1016/j.ijpharm.2016.01.019	PROPN
admet-1034	283	10	https://dx.doi.org/10.1016/j.ijpharm.2016.01.019	https://dx.doi.org/10.1016/j.ijpharm.2016.01.019	PROPN
admet-1034	283	11	https://doi.org/10.1016/s0021-9673(01)87961-9	https://doi.org/10.1016/s0021-9673(01)87961-9	NOUN
admet-1034	283	12	https://doi.org/10.1016/s0021-9673(01)87961-9	https://doi.org/10.1016/s0021-9673(01)87961-9	NOUN
admet-1034	283	13	grumetto	grumetto	NOUN
admet-1034	283	14	and	and	CCONJ
admet-1034	283	15	russo	russo	PROPN
admet-1034	283	16	admet	admet	PROPN
admet-1034	283	17	&	&	CCONJ
admet-1034	283	18	dmpk	dmpk	PROPN
admet-1034	283	19	9(4	9(4	PROPN
admet-1034	283	20	)	)	PUNCT
admet-1034	283	21	(	(	PUNCT
admet-1034	283	22	2021	2021	NUM
admet-1034	283	23	)	)	PUNCT
admet-1034	283	24	267	267	NUM
admet-1034	283	25	-	-	SYM
admet-1034	283	26	281	281	NUM
admet-1034	283	27	280	280	NUM
admet-1034	283	28	[	[	X
admet-1034	283	29	21	21	NUM
admet-1034	283	30	]	]	X
admet-1034	283	31	t.s	t.s	PROPN
admet-1034	283	32	.	.	PROPN
admet-1034	283	33	carpenter	carpenter	PROPN
admet-1034	283	34	,	,	PUNCT
admet-1034	283	35	d.a	d.a	PROPN
admet-1034	283	36	.	.	PROPN
admet-1034	283	37	kirshner	kirshner	PROPN
admet-1034	283	38	,	,	PUNCT
admet-1034	283	39	e.y	e.y	PROPN
admet-1034	283	40	.	.	PROPN
admet-1034	283	41	lau	lau	PROPN
admet-1034	283	42	,	,	PUNCT
admet-1034	283	43	s.e	s.e	PROPN
admet-1034	283	44	.	.	PROPN
admet-1034	283	45	wong	wong	PROPN
admet-1034	283	46	,	,	PUNCT
admet-1034	283	47	j.p	j.p	PROPN
admet-1034	283	48	.	.	PROPN
admet-1034	283	49	nilmeier	nilmeier	PROPN
admet-1034	283	50	,	,	PUNCT
admet-1034	283	51	f.c	f.c	PROPN
admet-1034	283	52	.	.	PROPN
admet-1034	283	53	lightstone	lightstone	PROPN
admet-1034	283	54	.	.	PUNCT
admet-1034	284	1	a	a	DET
admet-1034	284	2	method	method	NOUN
admet-1034	284	3	to	to	PART
admet-1034	284	4	predict	predict	VERB
admet-1034	284	5	blood	blood	NOUN
admet-1034	284	6	-	-	PUNCT
admet-1034	284	7	brain	brain	NOUN
admet-1034	284	8	barrier	barrier	NOUN
admet-1034	284	9	permeability	permeability	NOUN
admet-1034	284	10	of	of	ADP
admet-1034	284	11	drug	drug	NOUN
admet-1034	284	12	-	-	PUNCT
admet-1034	284	13	like	like	ADJ
admet-1034	284	14	compounds	compound	NOUN
admet-1034	284	15	using	use	VERB
admet-1034	284	16	molecular	molecular	ADJ
admet-1034	284	17	dynamics	dynamic	NOUN
admet-1034	284	18	simulations	simulation	NOUN
admet-1034	284	19	.	.	PUNCT
admet-1034	285	1	biophys	biophy	NOUN
admet-1034	285	2	.	.	PUNCT
admet-1034	286	1	j.	j.	PROPN
admet-1034	286	2	107	107	PROPN
admet-1034	286	3	(	(	PUNCT
admet-1034	286	4	2014	2014	NUM
admet-1034	286	5	)	)	PUNCT
admet-1034	286	6	630	630	NUM
admet-1034	286	7	-	-	SYM
admet-1034	286	8	641	641	NUM
admet-1034	286	9	.	.	PUNCT
admet-1034	286	10	https://dx.doi.org/10.1016/j.bpj.2014.06.024	https://dx.doi.org/10.1016/j.bpj.2014.06.024	NOUN
admet-1034	286	11	.	.	PUNCT
admet-1034	287	1	[	[	X
admet-1034	287	2	22	22	NUM
admet-1034	287	3	]	]	X
admet-1034	287	4	g.	g.	PROPN
admet-1034	287	5	russo	russo	PROPN
admet-1034	287	6	,	,	PUNCT
admet-1034	287	7	f.	f.	PROPN
admet-1034	287	8	barbato	barbato	PROPN
admet-1034	287	9	,	,	PUNCT
admet-1034	287	10	l.	l.	PROPN
admet-1034	287	11	grumetto	grumetto	PROPN
admet-1034	287	12	,	,	PUNCT
admet-1034	287	13	l.	l.	PROPN
admet-1034	287	14	philippe	philippe	PROPN
admet-1034	287	15	,	,	PUNCT
admet-1034	287	16	f.	f.	PROPN
admet-1034	287	17	lynen	lynen	PROPN
admet-1034	287	18	,	,	PUNCT
admet-1034	287	19	g.h	g.h	PROPN
admet-1034	287	20	.	.	PROPN
admet-1034	287	21	goetz	goetz	PROPN
admet-1034	287	22	.	.	PUNCT
admet-1034	288	1	entry	entry	NOUN
admet-1034	288	2	of	of	ADP
admet-1034	288	3	therapeutics	therapeutic	NOUN
admet-1034	288	4	into	into	ADP
admet-1034	288	5	the	the	DET
admet-1034	288	6	brain	brain	NOUN
admet-1034	288	7	:	:	PUNCT
admet-1034	288	8	influence	influence	NOUN
admet-1034	288	9	of	of	ADP
admet-1034	288	10	exposed	expose	VERB
admet-1034	288	11	polarity	polarity	NOUN
admet-1034	288	12	calculated	calculate	VERB
admet-1034	288	13	in	in	ADP
admet-1034	288	14	silico	silico	NOUN
admet-1034	288	15	and	and	CCONJ
admet-1034	288	16	measured	measure	VERB
admet-1034	288	17	in	in	ADP
admet-1034	288	18	vitro	vitro	X
admet-1034	288	19	by	by	ADP
admet-1034	288	20	supercritical	supercritical	ADJ
admet-1034	288	21	fluid	fluid	NOUN
admet-1034	288	22	chromatography	chromatography	NOUN
admet-1034	288	23	.	.	PUNCT
admet-1034	289	1	int	int	NOUN
admet-1034	289	2	.	.	PUNCT
admet-1034	290	1	j.	j.	PROPN
admet-1034	290	2	pharm	pharm	PROPN
admet-1034	290	3	.	.	PUNCT
admet-1034	291	1	560	560	NUM
admet-1034	291	2	(	(	PUNCT
admet-1034	291	3	2019	2019	NUM
admet-1034	291	4	)	)	PUNCT
admet-1034	291	5	294	294	NUM
admet-1034	291	6	-	-	SYM
admet-1034	291	7	305	305	NUM
admet-1034	291	8	.	.	PUNCT
admet-1034	292	1	https://dx.doi.org/10.1016/j.ijpharm.2019.02.008	https://dx.doi.org/10.1016/j.ijpharm.2019.02.008	NOUN
admet-1034	292	2	.	.	PUNCT
admet-1034	293	1	[	[	X
admet-1034	293	2	23	23	NUM
admet-1034	293	3	]	]	X
admet-1034	293	4	p.k	p.k	PROPN
admet-1034	293	5	.	.	PROPN
admet-1034	293	6	pandey	pandey	PROPN
admet-1034	293	7	,	,	PUNCT
admet-1034	293	8	a.k	a.k	PROPN
admet-1034	293	9	.	.	PROPN
admet-1034	293	10	sharma	sharma	PROPN
admet-1034	293	11	,	,	PUNCT
admet-1034	293	12	u.	u.	PROPN
admet-1034	293	13	gupta	gupta	PROPN
admet-1034	293	14	.	.	PUNCT
admet-1034	294	1	blood	blood	NOUN
admet-1034	294	2	brain	brain	NOUN
admet-1034	294	3	barrier	barrier	NOUN
admet-1034	294	4	:	:	PUNCT
admet-1034	294	5	an	an	DET
admet-1034	294	6	overview	overview	NOUN
admet-1034	294	7	on	on	ADP
admet-1034	294	8	strategies	strategy	NOUN
admet-1034	294	9	in	in	ADP
admet-1034	294	10	drug	drug	NOUN
admet-1034	294	11	delivery	delivery	NOUN
admet-1034	294	12	,	,	PUNCT
admet-1034	294	13	realistic	realistic	ADJ
admet-1034	294	14	in	in	ADP
admet-1034	294	15	vitro	vitro	X
admet-1034	294	16	modeling	modeling	NOUN
admet-1034	294	17	and	and	CCONJ
admet-1034	294	18	in	in	ADP
admet-1034	294	19	vivo	vivo	ADJ
admet-1034	294	20	live	live	ADJ
admet-1034	294	21	tracking	tracking	NOUN
admet-1034	294	22	.	.	PUNCT
admet-1034	295	1	tissue	tissue	NOUN
admet-1034	295	2	barriers	barrier	NOUN
admet-1034	295	3	4	4	NUM
admet-1034	295	4	(	(	PUNCT
admet-1034	295	5	2016	2016	NUM
admet-1034	295	6	)	)	PUNCT
admet-1034	295	7	e1129476	e1129476	PROPN
admet-1034	295	8	.	.	PUNCT
admet-1034	296	1	https://dx.doi.org/10.1080/21688370.2015.1129476	https://dx.doi.org/10.1080/21688370.2015.1129476	PROPN
admet-1034	296	2	.	.	PUNCT
admet-1034	297	1	[	[	X
admet-1034	297	2	24	24	NUM
admet-1034	297	3	]	]	X
admet-1034	297	4	g.	g.	PROPN
admet-1034	297	5	russo	russo	PROPN
admet-1034	297	6	,	,	PUNCT
admet-1034	297	7	l.	l.	PROPN
admet-1034	297	8	grumetto	grumetto	PROPN
admet-1034	297	9	,	,	PUNCT
admet-1034	297	10	f.	f.	PROPN
admet-1034	297	11	barbato	barbato	PROPN
admet-1034	297	12	,	,	PUNCT
admet-1034	297	13	g.	g.	PROPN
admet-1034	297	14	vistoli	vistoli	PROPN
admet-1034	297	15	,	,	PUNCT
admet-1034	297	16	a.	a.	NOUN
admet-1034	297	17	pedretti	pedretti	PROPN
admet-1034	297	18	.	.	PUNCT
admet-1034	298	1	prediction	prediction	NOUN
admet-1034	298	2	and	and	CCONJ
admet-1034	298	3	mechanism	mechanism	NOUN
admet-1034	298	4	elucidation	elucidation	NOUN
admet-1034	298	5	of	of	ADP
admet-1034	298	6	analyte	analyte	NOUN
admet-1034	298	7	retention	retention	NOUN
admet-1034	298	8	on	on	ADP
admet-1034	298	9	phospholipid	phospholipid	NOUN
admet-1034	298	10	stationary	stationary	ADJ
admet-1034	298	11	phases	phase	NOUN
admet-1034	298	12	(	(	PUNCT
admet-1034	298	13	iam	iam	PROPN
admet-1034	298	14	-	-	PUNCT
admet-1034	298	15	hplc	hplc	NOUN
admet-1034	298	16	)	)	PUNCT
admet-1034	298	17	by	by	ADP
admet-1034	298	18	in	in	ADP
admet-1034	298	19	silico	silico	NOUN
admet-1034	298	20	calculated	calculate	VERB
admet-1034	298	21	physicochemical	physicochemical	ADJ
admet-1034	298	22	descriptors	descriptor	NOUN
admet-1034	298	23	.	.	PUNCT
admet-1034	299	1	eur	eur	PROPN
admet-1034	299	2	.	.	PUNCT
admet-1034	300	1	j.	j.	PROPN
admet-1034	300	2	pharm	pharm	PROPN
admet-1034	300	3	.	.	PUNCT
admet-1034	301	1	sci	sci	PROPN
admet-1034	301	2	.	.	PROPN
admet-1034	302	1	99	99	NUM
admet-1034	302	2	(	(	PUNCT
admet-1034	302	3	2017	2017	NUM
admet-1034	302	4	)	)	PUNCT
admet-1034	302	5	173	173	NUM
admet-1034	302	6	-	-	SYM
admet-1034	302	7	184	184	NUM
admet-1034	302	8	.	.	PUNCT
admet-1034	303	1	https://dx.doi.org/10.1016/j.ejps.2016.11.026	https://dx.doi.org/10.1016/j.ejps.2016.11.026	NOUN
admet-1034	303	2	.	.	PUNCT
admet-1034	304	1	[	[	X
admet-1034	304	2	25	25	NUM
admet-1034	304	3	]	]	X
admet-1034	304	4	d.s	d.s	PROPN
admet-1034	304	5	.	.	PROPN
admet-1034	304	6	wishart	wishart	PROPN
admet-1034	304	7	,	,	PUNCT
admet-1034	304	8	y.d	y.d	PROPN
admet-1034	304	9	.	.	PROPN
admet-1034	304	10	feunang	feunang	PROPN
admet-1034	304	11	,	,	PUNCT
admet-1034	304	12	a.c	a.c	PROPN
admet-1034	304	13	.	.	PROPN
admet-1034	304	14	guo	guo	PROPN
admet-1034	304	15	,	,	PUNCT
admet-1034	304	16	e.j	e.j	PROPN
admet-1034	304	17	.	.	PROPN
admet-1034	304	18	lo	lo	PROPN
admet-1034	304	19	,	,	PUNCT
admet-1034	304	20	a.	a.	NOUN
admet-1034	304	21	marcu	marcu	PROPN
admet-1034	304	22	,	,	PUNCT
admet-1034	304	23	j.r	j.r	PROPN
admet-1034	304	24	.	.	PROPN
admet-1034	304	25	grant	grant	PROPN
admet-1034	304	26	,	,	PUNCT
admet-1034	304	27	t.	t.	PROPN
admet-1034	304	28	sajed	sajed	PROPN
admet-1034	304	29	,	,	PUNCT
admet-1034	304	30	d.	d.	PROPN
admet-1034	304	31	johnson	johnson	PROPN
admet-1034	304	32	,	,	PUNCT
admet-1034	304	33	c.	c.	PROPN
admet-1034	304	34	li	li	PROPN
admet-1034	304	35	,	,	PUNCT
admet-1034	304	36	z.	z.	PROPN
admet-1034	304	37	sayeeda	sayeeda	PROPN
admet-1034	304	38	,	,	PUNCT
admet-1034	304	39	n.	n.	PROPN
admet-1034	304	40	assempour	assempour	PROPN
admet-1034	304	41	,	,	PUNCT
admet-1034	304	42	i.	i.	PROPN
admet-1034	304	43	iynkkaran	iynkkaran	PROPN
admet-1034	304	44	,	,	PUNCT
admet-1034	304	45	y.	y.	PROPN
admet-1034	304	46	liu	liu	PROPN
admet-1034	304	47	,	,	PUNCT
admet-1034	304	48	a.	a.	PROPN
admet-1034	304	49	maciejewski	maciejewski	PROPN
admet-1034	304	50	,	,	PUNCT
admet-1034	304	51	n.	n.	PROPN
admet-1034	304	52	gale	gale	PROPN
admet-1034	304	53	,	,	PUNCT
admet-1034	304	54	a.	a.	PROPN
admet-1034	304	55	wilson	wilson	PROPN
admet-1034	304	56	,	,	PUNCT
admet-1034	304	57	l.	l.	PROPN
admet-1034	304	58	chin	chin	PROPN
admet-1034	304	59	,	,	PUNCT
admet-1034	304	60	r.	r.	PROPN
admet-1034	304	61	cummings	cummings	PROPN
admet-1034	304	62	,	,	PUNCT
admet-1034	304	63	d.	d.	PROPN
admet-1034	304	64	le	le	PROPN
admet-1034	304	65	,	,	PUNCT
admet-1034	304	66	a.	a.	PROPN
admet-1034	304	67	pon	pon	PROPN
admet-1034	304	68	,	,	PUNCT
admet-1034	304	69	c.	c.	PROPN
admet-1034	304	70	knox	knox	PROPN
admet-1034	304	71	,	,	PUNCT
admet-1034	304	72	m.	m.	PROPN
admet-1034	304	73	wilson	wilson	PROPN
admet-1034	304	74	.	.	PUNCT
admet-1034	305	1	drugbank	drugbank	VERB
admet-1034	305	2	5.0	5.0	NUM
admet-1034	305	3	:	:	PUNCT
admet-1034	305	4	a	a	DET
admet-1034	305	5	major	major	ADJ
admet-1034	305	6	update	update	NOUN
admet-1034	305	7	to	to	ADP
admet-1034	305	8	the	the	DET
admet-1034	305	9	drugbank	drugbank	NOUN
admet-1034	305	10	database	database	NOUN
admet-1034	305	11	for	for	ADP
admet-1034	305	12	2018	2018	NUM
admet-1034	305	13	.	.	PUNCT
admet-1034	306	1	nucleic	nucleic	ADJ
admet-1034	306	2	acids	acid	NOUN
admet-1034	306	3	res	re	NOUN
admet-1034	306	4	.	.	PUNCT
admet-1034	307	1	46	46	NUM
admet-1034	307	2	(	(	PUNCT
admet-1034	307	3	2018	2018	NUM
admet-1034	307	4	)	)	PUNCT
admet-1034	308	1	d1074	d1074	PROPN
admet-1034	308	2	-	-	PUNCT
admet-1034	308	3	d1082	d1082	PROPN
admet-1034	308	4	.	.	PUNCT
admet-1034	309	1	https://dx.doi.org/10.1093/nar/gkx1037	https://dx.doi.org/10.1093/nar/gkx1037	NOUN
admet-1034	309	2	.	.	PUNCT
admet-1034	310	1	[	[	X
admet-1034	310	2	26	26	NUM
admet-1034	310	3	]	]	X
admet-1034	310	4	i.v	i.v	PROPN
admet-1034	310	5	.	.	PUNCT
admet-1034	310	6	tetko	tetko	PROPN
admet-1034	310	7	,	,	PUNCT
admet-1034	310	8	v.y	v.y	PROPN
admet-1034	310	9	.	.	PROPN
admet-1034	310	10	tanchuk	tanchuk	PROPN
admet-1034	310	11	.	.	PUNCT
admet-1034	311	1	application	application	NOUN
admet-1034	311	2	of	of	ADP
admet-1034	311	3	associative	associative	ADJ
admet-1034	311	4	neural	neural	ADJ
admet-1034	311	5	networks	network	NOUN
admet-1034	311	6	for	for	ADP
admet-1034	311	7	prediction	prediction	NOUN
admet-1034	311	8	of	of	ADP
admet-1034	311	9	lipophilicity	lipophilicity	NOUN
admet-1034	311	10	in	in	ADP
admet-1034	311	11	alogps	alogps	PROPN
admet-1034	311	12	2.1	2.1	NUM
admet-1034	311	13	program	program	NOUN
admet-1034	311	14	.	.	PUNCT
admet-1034	312	1	j.	j.	PROPN
admet-1034	312	2	chem	chem	PROPN
admet-1034	312	3	.	.	PUNCT
admet-1034	313	1	inf	inf	PROPN
admet-1034	313	2	.	.	PUNCT
admet-1034	313	3	comput	comput	PROPN
admet-1034	313	4	.	.	PUNCT
admet-1034	314	1	sci	sci	PROPN
admet-1034	314	2	.	.	PROPN
admet-1034	315	1	42	42	NUM
admet-1034	315	2	(	(	PUNCT
admet-1034	315	3	2002	2002	NUM
admet-1034	315	4	)	)	PUNCT
admet-1034	315	5	1136	1136	NUM
admet-1034	315	6	-	-	SYM
admet-1034	315	7	1145	1145	NUM
admet-1034	315	8	.	.	PUNCT
admet-1034	316	1	https://dx.doi.org/10.1021/ci025515j	https://dx.doi.org/10.1021/ci025515j	PROPN
admet-1034	316	2	.	.	PUNCT
admet-1034	317	1	[	[	X
admet-1034	317	2	27	27	NUM
admet-1034	317	3	]	]	PUNCT
admet-1034	317	4	marvinsketch	marvinsketch	NOUN
admet-1034	317	5	version	version	NOUN
admet-1034	317	6	17.1.16.0	17.1.16.0	NUM
admet-1034	317	7	,	,	PUNCT
admet-1034	317	8	chemaxon	chemaxon	PROPN
admet-1034	317	9	ltd	ltd	PROPN
admet-1034	317	10	,	,	PUNCT
admet-1034	317	11	budapest	budapest	PROPN
admet-1034	317	12	,	,	PUNCT
admet-1034	317	13	hungary	hungary	PROPN
admet-1034	317	14	http://www.chemaxon.com	http://www.chemaxon.com	X
admet-1034	317	15	(	(	PUNCT
admet-1034	317	16	2017	2017	NUM
admet-1034	317	17	)	)	PUNCT
admet-1034	317	18	.	.	PUNCT
admet-1034	318	1	[	[	X
admet-1034	318	2	28	28	NUM
admet-1034	318	3	]	]	X
admet-1034	318	4	j.a	j.a	PROPN
admet-1034	318	5	.	.	PROPN
admet-1034	318	6	platts	platts	PROPN
admet-1034	318	7	,	,	PUNCT
admet-1034	318	8	m.h	m.h	PROPN
admet-1034	318	9	.	.	PROPN
admet-1034	318	10	abraham	abraham	PROPN
admet-1034	318	11	,	,	PUNCT
admet-1034	318	12	y.h	y.h	PROPN
admet-1034	318	13	.	.	PROPN
admet-1034	318	14	zhao	zhao	PROPN
admet-1034	318	15	,	,	PUNCT
admet-1034	318	16	a.	a.	PROPN
admet-1034	318	17	hersey	hersey	PROPN
admet-1034	318	18	,	,	PUNCT
admet-1034	318	19	l.	l.	PROPN
admet-1034	318	20	ijaz	ijaz	PROPN
admet-1034	318	21	,	,	PUNCT
admet-1034	318	22	d.	d.	PROPN
admet-1034	318	23	butina	butina	PROPN
admet-1034	318	24	.	.	PUNCT
admet-1034	319	1	correlation	correlation	NOUN
admet-1034	319	2	and	and	CCONJ
admet-1034	319	3	prediction	prediction	NOUN
admet-1034	319	4	of	of	ADP
admet-1034	319	5	a	a	DET
admet-1034	319	6	large	large	ADJ
admet-1034	319	7	blood	blood	NOUN
admet-1034	319	8	-	-	PUNCT
admet-1034	319	9	brain	brain	NOUN
admet-1034	319	10	distribution	distribution	NOUN
admet-1034	319	11	data	datum	NOUN
admet-1034	319	12	set	set	VERB
admet-1034	319	13	--	--	PUNCT
admet-1034	319	14	an	an	DET
admet-1034	319	15	lfer	lfer	NOUN
admet-1034	319	16	study	study	NOUN
admet-1034	319	17	.	.	PUNCT
admet-1034	320	1	eur	eur	PROPN
admet-1034	320	2	.	.	PUNCT
admet-1034	321	1	j.	j.	PROPN
admet-1034	321	2	med	med	PROPN
admet-1034	321	3	.	.	PROPN
admet-1034	321	4	chem	chem	PROPN
admet-1034	321	5	.	.	PUNCT
admet-1034	322	1	36	36	NUM
admet-1034	322	2	(	(	PUNCT
admet-1034	322	3	2001	2001	NUM
admet-1034	322	4	)	)	PUNCT
admet-1034	322	5	719	719	NUM
admet-1034	322	6	-	-	SYM
admet-1034	322	7	730	730	NUM
admet-1034	322	8	.	.	PUNCT
admet-1034	323	1	https://dx.doi.org/10.1016/s0223-5234(01)01269-7	https://dx.doi.org/10.1016/s0223-5234(01)01269-7	NOUN
admet-1034	323	2	.	.	PUNCT
admet-1034	324	1	[	[	X
admet-1034	324	2	29	29	NUM
admet-1034	324	3	]	]	X
admet-1034	324	4	w.c	w.c	PROPN
admet-1034	324	5	.	.	PROPN
admet-1034	324	6	griffin	griffin	PROPN
admet-1034	324	7	.	.	PUNCT
admet-1034	324	8	calculation	calculation	NOUN
admet-1034	324	9	of	of	ADP
admet-1034	324	10	hlb	hlb	PROPN
admet-1034	324	11	values	value	NOUN
admet-1034	324	12	of	of	ADP
admet-1034	324	13	non	non	ADJ
admet-1034	324	14	-	-	ADJ
admet-1034	324	15	ionic	ionic	ADJ
admet-1034	324	16	surfactants	surfactant	NOUN
admet-1034	324	17	.	.	PUNCT
admet-1034	325	1	j.	j.	PROPN
admet-1034	325	2	soc	soc	PROPN
admet-1034	325	3	.	.	PUNCT
admet-1034	326	1	cosmet	cosmet	VERB
admet-1034	326	2	.	.	PUNCT
admet-1034	327	1	chem	chem	NOUN
admet-1034	327	2	.	.	PUNCT
admet-1034	328	1	5	5	NUM
admet-1034	328	2	(	(	PUNCT
admet-1034	328	3	1954	1954	NUM
admet-1034	328	4	)	)	PUNCT
admet-1034	328	5	249256	249256	NUM
admet-1034	328	6	.	.	PUNCT
admet-1034	329	1	[	[	X
admet-1034	329	2	30	30	NUM
admet-1034	329	3	]	]	X
admet-1034	329	4	j.	j.	PROPN
admet-1034	329	5	davies	davies	PROPN
admet-1034	329	6	.	.	PUNCT
admet-1034	330	1	a	a	DET
admet-1034	330	2	quantitative	quantitative	ADJ
admet-1034	330	3	kinetic	kinetic	ADJ
admet-1034	330	4	theory	theory	NOUN
admet-1034	330	5	of	of	ADP
admet-1034	330	6	emulsion	emulsion	NOUN
admet-1034	330	7	type	type	NOUN
admet-1034	330	8	.	.	PUNCT
admet-1034	331	1	i	i	PRON
admet-1034	331	2	.	.	PUNCT
admet-1034	332	1	physical	physical	ADJ
admet-1034	332	2	chemistry	chemistry	NOUN
admet-1034	332	3	of	of	ADP
admet-1034	332	4	the	the	DET
admet-1034	332	5	emulsifying	emulsifying	NOUN
admet-1034	332	6	.	.	PUNCT
admet-1034	333	1	2003	2003	NUM
admet-1034	333	2	.	.	PUNCT
admet-1034	334	1	[	[	X
admet-1034	334	2	31	31	NUM
admet-1034	334	3	]	]	PUNCT
admet-1034	334	4	molinspiration	molinspiration	NOUN
admet-1034	334	5	:	:	PUNCT
admet-1034	334	6	log	log	VERB
admet-1034	334	7	p	p	NOUN
admet-1034	334	8	n	n	CCONJ
admet-1034	334	9	-	-	PUNCT
admet-1034	334	10	octanol	octanol	NOUN
admet-1034	334	11	-	-	PUNCT
admet-1034	334	12	water	water	NOUN
admet-1034	334	13	partition	partition	NOUN
admet-1034	334	14	coefficient	coefficient	NOUN
admet-1034	334	15	.	.	PUNCT
admet-1034	335	1	http://www.molinspiration.com/services/logp.html	http://www.molinspiration.com/services/logp.html	PROPN
admet-1034	335	2	.	.	NOUN
admet-1034	335	3	2021	2021	NUM
admet-1034	335	4	.	.	PUNCT
admet-1034	336	1	[	[	X
admet-1034	336	2	32	32	NUM
admet-1034	336	3	]	]	PUNCT
admet-1034	336	4	a.	a.	NOUN
admet-1034	336	5	mauri	mauri	PROPN
admet-1034	336	6	,	,	PUNCT
admet-1034	336	7	v.	v.	PROPN
admet-1034	336	8	consonni	consonni	PROPN
admet-1034	336	9	,	,	PUNCT
admet-1034	336	10	r.	r.	PROPN
admet-1034	336	11	todeschini	todeschini	PROPN
admet-1034	336	12	,	,	PUNCT
admet-1034	336	13	molecular	molecular	ADJ
admet-1034	336	14	descriptors	descriptor	NOUN
admet-1034	336	15	,	,	PUNCT
admet-1034	336	16	in	in	ADP
admet-1034	336	17	:	:	PUNCT
admet-1034	336	18	j.	j.	PROPN
admet-1034	336	19	leszczynski	leszczynski	PROPN
admet-1034	336	20	,	,	PUNCT
admet-1034	336	21	a.	a.	PROPN
admet-1034	336	22	kaczmarek	kaczmarek	PROPN
admet-1034	336	23	-	-	PUNCT
admet-1034	336	24	kedziera	kedziera	PROPN
admet-1034	336	25	,	,	PUNCT
admet-1034	336	26	t.	t.	PROPN
admet-1034	336	27	puzyn	puzyn	PROPN
admet-1034	336	28	,	,	PUNCT
admet-1034	336	29	m.	m.	NOUN
admet-1034	336	30	g.	g.	PROPN
admet-1034	336	31	papadopoulos	papadopoulos	PROPN
admet-1034	336	32	,	,	PUNCT
admet-1034	336	33	h.	h.	PROPN
admet-1034	336	34	reis	reis	PROPN
admet-1034	336	35	,	,	PUNCT
admet-1034	336	36	m.	m.	NOUN
admet-1034	336	37	k.	k.	PROPN
admet-1034	336	38	shukla	shukla	PROPN
admet-1034	336	39	(	(	PUNCT
admet-1034	336	40	eds	eds	PROPN
admet-1034	336	41	.	.	PUNCT
admet-1034	336	42	)	)	PUNCT
admet-1034	336	43	handbook	handbook	NOUN
admet-1034	336	44	of	of	ADP
admet-1034	336	45	computational	computational	ADJ
admet-1034	336	46	chemistry	chemistry	NOUN
admet-1034	336	47	,	,	PUNCT
admet-1034	336	48	springer	springer	NOUN
admet-1034	336	49	international	international	ADJ
admet-1034	336	50	publishing	publishing	NOUN
admet-1034	336	51	,	,	PUNCT
admet-1034	336	52	cham	cham	NOUN
admet-1034	336	53	,	,	PUNCT
admet-1034	336	54	2017	2017	NUM
admet-1034	336	55	,	,	PUNCT
admet-1034	336	56	pp	pp	ADJ
admet-1034	336	57	.	.	PUNCT
admet-1034	336	58	2065	2065	NUM
admet-1034	336	59	-	-	SYM
admet-1034	336	60	2093	2093	NUM
admet-1034	336	61	.	.	PUNCT
admet-1034	337	1	https://dx.doi.org/10.1007/978-3-31927282-5_51	https://dx.doi.org/10.1007/978-3-31927282-5_51	PROPN
admet-1034	337	2	.	.	PUNCT
admet-1034	338	1	[	[	X
admet-1034	338	2	33	33	NUM
admet-1034	338	3	]	]	PUNCT
admet-1034	338	4	a.	a.	NOUN
admet-1034	338	5	pedretti	pedretti	PROPN
admet-1034	338	6	,	,	PUNCT
admet-1034	338	7	l.	l.	PROPN
admet-1034	338	8	villa	villa	PROPN
admet-1034	338	9	,	,	PUNCT
admet-1034	338	10	g.	g.	PROPN
admet-1034	338	11	vistoli	vistoli	PROPN
admet-1034	338	12	.	.	PUNCT
admet-1034	339	1	vega	vega	PROPN
admet-1034	339	2	-	-	PUNCT
admet-1034	339	3	an	an	DET
admet-1034	339	4	open	open	ADJ
admet-1034	339	5	platform	platform	NOUN
admet-1034	339	6	to	to	PART
admet-1034	339	7	develop	develop	VERB
admet-1034	339	8	chemo	chemo	NOUN
admet-1034	339	9	-	-	PUNCT
admet-1034	339	10	bio	bio	NOUN
admet-1034	339	11	-	-	PUNCT
admet-1034	339	12	informatics	informatic	NOUN
admet-1034	339	13	applications	application	NOUN
admet-1034	339	14	,	,	PUNCT
admet-1034	339	15	using	use	VERB
admet-1034	339	16	plug	plug	NOUN
admet-1034	339	17	-	-	PUNCT
admet-1034	339	18	in	in	ADP
admet-1034	339	19	architecture	architecture	NOUN
admet-1034	339	20	and	and	CCONJ
admet-1034	339	21	script	script	NOUN
admet-1034	339	22	programming	programming	NOUN
admet-1034	339	23	.	.	PUNCT
admet-1034	340	1	j.	j.	PROPN
admet-1034	340	2	comput	comput	PROPN
admet-1034	340	3	.	.	PUNCT
admet-1034	340	4	aided	aid	VERB
admet-1034	340	5	mol	mol	PROPN
admet-1034	340	6	.	.	PUNCT
admet-1034	341	1	des	des	PROPN
admet-1034	341	2	.	.	PROPN
admet-1034	341	3	18	18	NUM
admet-1034	341	4	(	(	PUNCT
admet-1034	341	5	2004	2004	NUM
admet-1034	341	6	)	)	PUNCT
admet-1034	341	7	167	167	NUM
admet-1034	341	8	-	-	SYM
admet-1034	341	9	173	173	NUM
admet-1034	341	10	.	.	PUNCT
admet-1034	342	1	https://dx.doi.org/	https://dx.doi.org/	X
admet-1034	342	2	10.1023	10.1023	NUM
admet-1034	342	3	/	/	SYM
admet-1034	342	4	b	b	NOUN
admet-1034	342	5	:	:	PUNCT
admet-1034	342	6	jcam.0000035186.90683.f2	jcam.0000035186.90683.f2	PROPN
admet-1034	342	7	.	.	PUNCT
admet-1034	343	1	[	[	X
admet-1034	343	2	34	34	NUM
admet-1034	343	3	]	]	X
admet-1034	343	4	g.	g.	PROPN
admet-1034	343	5	russo	russo	PROPN
admet-1034	343	6	,	,	PUNCT
admet-1034	343	7	l.	l.	PROPN
admet-1034	343	8	grumetto	grumetto	PROPN
admet-1034	343	9	,	,	PUNCT
admet-1034	343	10	r.	r.	PROPN
admet-1034	343	11	szucs	szucs	PROPN
admet-1034	343	12	,	,	PUNCT
admet-1034	343	13	f.	f.	PROPN
admet-1034	343	14	barbato	barbato	PROPN
admet-1034	343	15	,	,	PUNCT
admet-1034	343	16	f.	f.	PROPN
admet-1034	343	17	lynen	lynen	PROPN
admet-1034	343	18	.	.	PUNCT
admet-1034	344	1	determination	determination	NOUN
admet-1034	344	2	of	of	ADP
admet-1034	344	3	in	in	ADP
admet-1034	344	4	vitro	vitro	X
admet-1034	344	5	and	and	CCONJ
admet-1034	344	6	in	in	ADP
admet-1034	344	7	silico	silico	NOUN
admet-1034	344	8	indexes	index	NOUN
admet-1034	344	9	for	for	ADP
admet-1034	344	10	the	the	DET
admet-1034	344	11	modeling	modeling	NOUN
admet-1034	344	12	of	of	ADP
admet-1034	344	13	blood	blood	NOUN
admet-1034	344	14	-	-	PUNCT
admet-1034	344	15	brain	brain	NOUN
admet-1034	344	16	barrier	barrier	NOUN
admet-1034	344	17	partitioning	partitioning	NOUN
admet-1034	344	18	of	of	ADP
admet-1034	344	19	drugs	drug	NOUN
admet-1034	344	20	via	via	ADP
admet-1034	344	21	micellar	micellar	NOUN
admet-1034	344	22	and	and	CCONJ
admet-1034	344	23	immobilized	immobilize	VERB
admet-1034	344	24	artificial	artificial	ADJ
admet-1034	344	25	membrane	membrane	NOUN
admet-1034	344	26	liquid	liquid	ADJ
admet-1034	344	27	chromatography	chromatography	NOUN
admet-1034	344	28	.	.	PUNCT
admet-1034	345	1	j.	j.	PROPN
admet-1034	345	2	med	med	PROPN
admet-1034	345	3	.	.	PROPN
admet-1034	345	4	chem	chem	PROPN
admet-1034	345	5	.	.	PUNCT
admet-1034	346	1	60	60	NUM
admet-1034	346	2	(	(	PUNCT
admet-1034	346	3	2017	2017	NUM
admet-1034	346	4	)	)	PUNCT
admet-1034	346	5	3739	3739	NUM
admet-1034	346	6	-	-	SYM
admet-1034	346	7	3754	3754	NUM
admet-1034	346	8	.	.	PUNCT
admet-1034	347	1	https://dx.doi.org/10.1021/acs.jmedchem.6b01811	https://dx.doi.org/10.1021/acs.jmedchem.6b01811	ADV
admet-1034	347	2	.	.	PUNCT
admet-1034	348	1	[	[	X
admet-1034	348	2	35	35	NUM
admet-1034	348	3	]	]	X
admet-1034	348	4	j.	j.	PROPN
admet-1034	348	5	verma	verma	PROPN
admet-1034	348	6	,	,	PUNCT
admet-1034	348	7	v.m	v.m	PROPN
admet-1034	348	8	.	.	PROPN
admet-1034	348	9	khedkar	khedkar	PROPN
admet-1034	348	10	,	,	PUNCT
admet-1034	348	11	e.c	e.c	PROPN
admet-1034	348	12	.	.	PROPN
admet-1034	348	13	coutinho	coutinho	PROPN
admet-1034	348	14	.	.	PUNCT
admet-1034	349	1	3d	3d	NUM
admet-1034	349	2	-	-	PUNCT
admet-1034	349	3	qsar	qsar	NOUN
admet-1034	349	4	in	in	ADP
admet-1034	349	5	drug	drug	NOUN
admet-1034	349	6	design	design	NOUN
admet-1034	349	7	--	--	PUNCT
admet-1034	349	8	a	a	DET
admet-1034	349	9	review	review	NOUN
admet-1034	349	10	.	.	PUNCT
admet-1034	350	1	curr	curr	PROPN
admet-1034	350	2	.	.	PUNCT
admet-1034	350	3	top	top	PROPN
admet-1034	350	4	.	.	PUNCT
admet-1034	351	1	med	med	PROPN
admet-1034	351	2	.	.	PROPN
admet-1034	351	3	chem	chem	PROPN
admet-1034	351	4	.	.	PUNCT
admet-1034	352	1	10	10	NUM
admet-1034	352	2	(	(	PUNCT
admet-1034	352	3	2010	2010	NUM
admet-1034	352	4	)	)	PUNCT
admet-1034	352	5	95	95	NUM
admet-1034	352	6	-	-	SYM
admet-1034	352	7	115	115	NUM
admet-1034	352	8	.	.	PUNCT
admet-1034	353	1	https://dx.doi.org/10.2174/156802610790232260	https://dx.doi.org/10.2174/156802610790232260	NOUN
admet-1034	353	2	.	.	PUNCT
admet-1034	354	1	[	[	X
admet-1034	354	2	36	36	NUM
admet-1034	354	3	]	]	PUNCT
admet-1034	354	4	s.	s.	PROPN
admet-1034	354	5	kim	kim	PROPN
admet-1034	354	6	,	,	PUNCT
admet-1034	354	7	j.	j.	PROPN
admet-1034	354	8	chen	chen	PROPN
admet-1034	354	9	,	,	PUNCT
admet-1034	354	10	t.	t.	PROPN
admet-1034	354	11	cheng	cheng	PROPN
admet-1034	354	12	,	,	PUNCT
admet-1034	354	13	a.	a.	PROPN
admet-1034	354	14	gindulyte	gindulyte	PROPN
admet-1034	354	15	,	,	PUNCT
admet-1034	354	16	j.	j.	PROPN
admet-1034	354	17	he	he	PROPN
admet-1034	354	18	,	,	PUNCT
admet-1034	354	19	s.	s.	PROPN
admet-1034	354	20	he	he	PRON
admet-1034	354	21	,	,	PUNCT
admet-1034	354	22	q.	q.	PROPN
admet-1034	354	23	li	li	PROPN
admet-1034	354	24	,	,	PUNCT
admet-1034	354	25	b.a	b.a	PROPN
admet-1034	354	26	.	.	PROPN
admet-1034	354	27	shoemaker	shoemaker	PROPN
admet-1034	354	28	,	,	PUNCT
admet-1034	354	29	p.a	p.a	PROPN
admet-1034	354	30	.	.	PROPN
admet-1034	354	31	thiessen	thiessen	PROPN
admet-1034	354	32	,	,	PUNCT
admet-1034	354	33	b.	b.	PROPN
admet-1034	354	34	yu	yu	PROPN
admet-1034	354	35	,	,	PUNCT
admet-1034	354	36	l.	l.	PROPN
admet-1034	354	37	zaslavsky	zaslavsky	PROPN
admet-1034	354	38	,	,	PUNCT
admet-1034	354	39	j.	j.	PROPN
admet-1034	354	40	zhang	zhang	PROPN
admet-1034	354	41	,	,	PUNCT
admet-1034	354	42	e.e	e.e	PROPN
admet-1034	354	43	.	.	PROPN
admet-1034	354	44	bolton	bolton	PROPN
admet-1034	354	45	.	.	PUNCT
admet-1034	354	46	pubchem	pubchem	NOUN
admet-1034	354	47	in	in	ADP
admet-1034	354	48	2021	2021	NUM
admet-1034	354	49	:	:	PUNCT
admet-1034	354	50	new	new	ADJ
admet-1034	354	51	data	datum	NOUN
admet-1034	354	52	content	content	NOUN
admet-1034	354	53	and	and	CCONJ
admet-1034	354	54	improved	improve	VERB
admet-1034	354	55	web	web	NOUN
admet-1034	354	56	interfaces	interface	NOUN
admet-1034	354	57	.	.	PUNCT
admet-1034	355	1	nucleic	nucleic	ADJ
admet-1034	355	2	acids	acid	NOUN
admet-1034	355	3	research	research	NOUN
admet-1034	355	4	49	49	NUM
admet-1034	355	5	(	(	PUNCT
admet-1034	355	6	2020	2020	NUM
admet-1034	355	7	)	)	PUNCT
admet-1034	355	8	d1388	d1388	NOUN
admet-1034	355	9	-	-	PUNCT
admet-1034	355	10	d1395	d1395	PROPN
admet-1034	355	11	.	.	PUNCT
admet-1034	356	1	https://dx.doi.org/10.1093/nar/gkaa971	https://dx.doi.org/10.1093/nar/gkaa971	X
admet-1034	356	2	.	.	PUNCT
admet-1034	357	1	[	[	X
admet-1034	357	2	37	37	NUM
admet-1034	357	3	]	]	PUNCT
admet-1034	357	4	m.s.f.w.-b.p.v	m.s.f.w.-b.p.v	PROPN
admet-1034	357	5	.	.	PUNCT
admet-1034	358	1	http://www.chemaxon.com/products/marvin/marvinsketch/.	http://www.chemaxon.com/products/marvin/marvinsketch/.	PROPN
admet-1034	358	2	calculation	calculation	NOUN
admet-1034	358	3	module	module	NOUN
admet-1034	358	4	designed	design	VERB
admet-1034	358	5	by	by	ADP
admet-1034	358	6	chemaxon	chemaxon	NOUN
admet-1034	358	7	.	.	PUNCT
admet-1034	359	1	https://dx.doi.org/10.1016/j.bpj.2014.06.024	https://dx.doi.org/10.1016/j.bpj.2014.06.024	PROPN
admet-1034	359	2	https://dx.doi.org/10.1016/j.ijpharm.2019.02.008	https://dx.doi.org/10.1016/j.ijpharm.2019.02.008	PROPN
admet-1034	359	3	https://dx.doi.org/10.1080/21688370.2015.1129476	https://dx.doi.org/10.1080/21688370.2015.1129476	PROPN
admet-1034	359	4	https://dx.doi.org/10.1080/21688370.2015.1129476	https://dx.doi.org/10.1080/21688370.2015.1129476	PROPN
admet-1034	359	5	https://dx.doi.org/10.1016/j.ejps.2016.11.026	https://dx.doi.org/10.1016/j.ejps.2016.11.026	PROPN
admet-1034	359	6	https://dx.doi.org/10.1016/j.ejps.2016.11.026	https://dx.doi.org/10.1016/j.ejps.2016.11.026	PROPN
admet-1034	359	7	https://dx.doi.org/10.1093/nar/gkx1037	https://dx.doi.org/10.1093/nar/gkx1037	ADJ
admet-1034	359	8	https://dx.doi.org/10.1021/ci025515j	https://dx.doi.org/10.1021/ci025515j	PROPN
admet-1034	359	9	https://dx.doi.org/10.1021/ci025515j	https://dx.doi.org/10.1021/ci025515j	PROPN
admet-1034	359	10	http://www.chemaxon.com/	http://www.chemaxon.com/	NOUN
admet-1034	359	11	https://dx.doi.org/10.1016/s0223-5234(01)01269-7	https://dx.doi.org/10.1016/s0223-5234(01)01269-7	PROPN
admet-1034	359	12	http://www.molinspiration.com/services/logp.html	http://www.molinspiration.com/services/logp.html	PROPN
admet-1034	359	13	http://www.molinspiration.com/services/logp.html	http://www.molinspiration.com/services/logp.html	PROPN
admet-1034	359	14	https://dx.doi.org/10.1007/978-3-319-27282-5_51	https://dx.doi.org/10.1007/978-3-319-27282-5_51	PROPN
admet-1034	360	1	https://dx.doi.org/10.1007/978-3-319-27282-5_51	https://dx.doi.org/10.1007/978-3-319-27282-5_51	INTJ
admet-1034	360	2	https://dx.doi.org/%2010.1023/b:jcam.0000035186.90683.f2	https://dx.doi.org/%2010.1023/b:jcam.0000035186.90683.f2	PROPN
admet-1034	360	3	https://dx.doi.org/10.1021/acs.jmedchem.6b01811	https://dx.doi.org/10.1021/acs.jmedchem.6b01811	PRON
admet-1034	360	4	https://dx.doi.org/10.1021/acs.jmedchem.6b01811	https://dx.doi.org/10.1021/acs.jmedchem.6b01811	DET
admet-1034	360	5	https://dx.doi.org/10.2174/156802610790232260	https://dx.doi.org/10.2174/156802610790232260	NOUN
admet-1034	361	1	https://dx.doi.org/10.1093/nar/gkaa971	https://dx.doi.org/10.1093/nar/gkaa971	PUNCT
admet-1034	362	1	http://www.chemaxon.com/products/marvin/marvinsketch/	http://www.chemaxon.com/products/marvin/marvinsketch/	PROPN
admet-1034	362	2	admet	admet	PROPN
admet-1034	362	3	&	&	CCONJ
admet-1034	362	4	dmpk	dmpk	PROPN
admet-1034	362	5	9(4	9(4	PROPN
admet-1034	362	6	)	)	PUNCT
admet-1034	362	7	(	(	PUNCT
admet-1034	362	8	2021	2021	NUM
admet-1034	362	9	)	)	PUNCT
admet-1034	362	10	267	267	NUM
admet-1034	362	11	-	-	SYM
admet-1034	362	12	281	281	NUM
admet-1034	362	13	bbb	bbb	PROPN
admet-1034	362	14	passage	passage	NOUN
admet-1034	362	15	based	base	VERB
admet-1034	362	16	on	on	ADP
admet-1034	362	17	in	in	ADP
admet-1034	362	18	silico	silico	NOUN
admet-1034	362	19	phospholipophilicity	phospholipophilicity	NOUN
admet-1034	362	20	doi	doi	NOUN
admet-1034	362	21	:	:	PUNCT
admet-1034	362	22	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	X
admet-1034	362	23	281	281	NUM
admet-1034	362	24	[	[	SYM
admet-1034	362	25	38	38	NUM
admet-1034	362	26	]	]	PUNCT
admet-1034	362	27	f.	f.	PROPN
admet-1034	362	28	tsopelas	tsopelas	PROPN
admet-1034	362	29	,	,	PUNCT
admet-1034	362	30	t.	t.	PROPN
admet-1034	362	31	vallianatou	vallianatou	PROPN
admet-1034	362	32	,	,	PUNCT
admet-1034	362	33	a.	a.	NOUN
admet-1034	362	34	tsantili	tsantili	NOUN
admet-1034	362	35	-	-	PUNCT
admet-1034	362	36	kakoulidou	kakoulidou	NOUN
admet-1034	362	37	.	.	PUNCT
admet-1034	363	1	advances	advance	NOUN
admet-1034	363	2	in	in	ADP
admet-1034	363	3	immobilized	immobilized	ADJ
admet-1034	363	4	artificial	artificial	ADJ
admet-1034	363	5	membrane	membrane	NOUN
admet-1034	363	6	(	(	PUNCT
admet-1034	363	7	iam	iam	PROPN
admet-1034	363	8	)	)	PUNCT
admet-1034	363	9	chromatography	chromatography	NOUN
admet-1034	363	10	for	for	ADP
admet-1034	363	11	novel	novel	ADJ
admet-1034	363	12	drug	drug	NOUN
admet-1034	363	13	discovery	discovery	NOUN
admet-1034	363	14	.	.	PUNCT
admet-1034	364	1	expert	expert	ADJ
admet-1034	364	2	opinion	opinion	NOUN
admet-1034	364	3	on	on	ADP
admet-1034	364	4	drug	drug	NOUN
admet-1034	364	5	discovery	discovery	NOUN
admet-1034	364	6	11	11	NUM
admet-1034	364	7	(	(	PUNCT
admet-1034	364	8	2016	2016	NUM
admet-1034	364	9	)	)	PUNCT
admet-1034	364	10	473	473	NUM
admet-1034	364	11	-	-	SYM
admet-1034	364	12	488	488	NUM
admet-1034	364	13	.	.	PUNCT
admet-1034	365	1	https://dx.doi.org/10.1517/17460441.2016.1160886	https://dx.doi.org/10.1517/17460441.2016.1160886	X
admet-1034	365	2	.	.	PUNCT
admet-1034	366	1	[	[	X
admet-1034	366	2	39	39	NUM
admet-1034	366	3	]	]	PUNCT
admet-1034	366	4	a.	a.	NOUN
admet-1034	366	5	taillardat	taillardat	PROPN
admet-1034	366	6	-	-	PUNCT
admet-1034	366	7	bertschinger	bertschinger	NOUN
admet-1034	366	8	,	,	PUNCT
admet-1034	366	9	f.	f.	PROPN
admet-1034	366	10	barbato	barbato	PROPN
admet-1034	366	11	,	,	PUNCT
admet-1034	366	12	m.t	m.t	PROPN
admet-1034	366	13	.	.	PROPN
admet-1034	366	14	quercia	quercia	PROPN
admet-1034	366	15	,	,	PUNCT
admet-1034	366	16	p.-a	p.-a	NOUN
admet-1034	366	17	.	.	PUNCT
admet-1034	367	1	carrupt	carrupt	PROPN
admet-1034	367	2	,	,	PUNCT
admet-1034	367	3	m.	m.	NOUN
admet-1034	367	4	reist	reist	PROPN
admet-1034	367	5	,	,	PUNCT
admet-1034	367	6	m.i	m.i	PROPN
admet-1034	367	7	.	.	PROPN
admet-1034	367	8	la	la	PROPN
admet-1034	367	9	rotonda	rotonda	PROPN
admet-1034	367	10	,	,	PUNCT
admet-1034	367	11	b.	b.	PROPN
admet-1034	367	12	testa	testa	PROPN
admet-1034	367	13	.	.	PUNCT
admet-1034	368	1	structural	structural	ADJ
admet-1034	368	2	properties	property	NOUN
admet-1034	368	3	governing	govern	VERB
admet-1034	368	4	retention	retention	NOUN
admet-1034	368	5	mechanisms	mechanism	NOUN
admet-1034	368	6	on	on	ADP
admet-1034	368	7	immobilized	immobilized	ADJ
admet-1034	368	8	artificial	artificial	ADJ
admet-1034	368	9	membrane	membrane	NOUN
admet-1034	368	10	(	(	PUNCT
admet-1034	368	11	iam	iam	PROPN
admet-1034	368	12	)	)	PUNCT
admet-1034	368	13	hplc	hplc	NOUN
admet-1034	368	14	columns	column	NOUN
admet-1034	368	15	.	.	PUNCT
admet-1034	369	1	helvetica	helvetica	PROPN
admet-1034	369	2	chimica	chimica	PROPN
admet-1034	369	3	acta	acta	PROPN
admet-1034	369	4	85	85	NUM
admet-1034	369	5	(	(	PUNCT
admet-1034	369	6	2002	2002	NUM
admet-1034	369	7	)	)	PUNCT
admet-1034	369	8	519	519	NUM
admet-1034	369	9	-	-	SYM
admet-1034	369	10	532	532	NUM
admet-1034	369	11	.	.	PUNCT
admet-1034	370	1	https://dx.doi.org/10.1002/15222675(200202)85:2<519::aid-hlca519>3.0.co;2-q	https://dx.doi.org/10.1002/15222675(200202)85:2<519::aid-hlca519>3.0.co;2-q	VERB
admet-1034	370	2	.	.	PUNCT
admet-1034	371	1	[	[	X
admet-1034	371	2	40	40	NUM
admet-1034	371	3	]	]	X
admet-1034	371	4	j.a	j.a	PROPN
admet-1034	371	5	.	.	PROPN
admet-1034	371	6	arnott	arnott	PROPN
admet-1034	371	7	,	,	PUNCT
admet-1034	371	8	s.l	s.l	PROPN
admet-1034	371	9	.	.	PROPN
admet-1034	371	10	planey	planey	NOUN
admet-1034	371	11	.	.	PUNCT
admet-1034	372	1	the	the	DET
admet-1034	372	2	influence	influence	NOUN
admet-1034	372	3	of	of	ADP
admet-1034	372	4	lipophilicity	lipophilicity	NOUN
admet-1034	372	5	in	in	ADP
admet-1034	372	6	drug	drug	NOUN
admet-1034	372	7	discovery	discovery	NOUN
admet-1034	372	8	and	and	CCONJ
admet-1034	372	9	design	design	NOUN
admet-1034	372	10	.	.	PUNCT
admet-1034	373	1	expert	expert	NOUN
admet-1034	373	2	opin	opin	NOUN
admet-1034	373	3	.	.	PUNCT
admet-1034	374	1	drug	drug	NOUN
admet-1034	374	2	discov	discov	NOUN
admet-1034	374	3	.	.	PUNCT
admet-1034	375	1	7	7	NUM
admet-1034	375	2	(	(	PUNCT
admet-1034	375	3	2012	2012	NUM
admet-1034	375	4	)	)	PUNCT
admet-1034	375	5	863	863	NUM
admet-1034	375	6	-	-	SYM
admet-1034	375	7	875	875	NUM
admet-1034	375	8	.	.	PUNCT
admet-1034	376	1	https://dx.doi.org/10.1517/17460441.2012.714363	https://dx.doi.org/10.1517/17460441.2012.714363	ADV
admet-1034	376	2	.	.	PUNCT
admet-1034	377	1	[	[	X
admet-1034	377	2	41	41	NUM
admet-1034	377	3	]	]	X
admet-1034	377	4	h.	h.	PROPN
admet-1034	377	5	wan	wan	PROPN
admet-1034	377	6	,	,	PUNCT
admet-1034	377	7	a.g	a.g	PROPN
admet-1034	377	8	.	.	PROPN
admet-1034	377	9	holmen	holmen	PROPN
admet-1034	377	10	.	.	PUNCT
admet-1034	378	1	high	high	ADJ
admet-1034	378	2	throughput	throughput	NOUN
admet-1034	378	3	screening	screening	NOUN
admet-1034	378	4	of	of	ADP
admet-1034	378	5	physicochemical	physicochemical	ADJ
admet-1034	378	6	properties	property	NOUN
admet-1034	378	7	and	and	CCONJ
admet-1034	378	8	in	in	ADP
admet-1034	378	9	vitro	vitro	X
admet-1034	378	10	adme	adme	NOUN
admet-1034	378	11	profiling	profiling	NOUN
admet-1034	378	12	in	in	ADP
admet-1034	378	13	drug	drug	NOUN
admet-1034	378	14	discovery	discovery	NOUN
admet-1034	378	15	.	.	PUNCT
admet-1034	379	1	comb	comb	NOUN
admet-1034	379	2	.	.	PUNCT
admet-1034	380	1	chem	chem	NOUN
admet-1034	380	2	.	.	PUNCT
admet-1034	381	1	high	high	ADJ
admet-1034	381	2	throughput	throughput	NOUN
admet-1034	381	3	screen	screen	NOUN
admet-1034	381	4	.	.	PUNCT
admet-1034	382	1	12	12	NUM
admet-1034	382	2	(	(	PUNCT
admet-1034	382	3	2009	2009	NUM
admet-1034	382	4	)	)	PUNCT
admet-1034	382	5	315	315	NUM
admet-1034	382	6	-	-	SYM
admet-1034	382	7	329	329	NUM
admet-1034	382	8	.	.	PUNCT
admet-1034	383	1	https://dx.doi.org/10.2174/138620709787581701	https://dx.doi.org/10.2174/138620709787581701	NOUN
admet-1034	383	2	.	.	PUNCT
admet-1034	384	1	[	[	X
admet-1034	384	2	42	42	NUM
admet-1034	384	3	]	]	PUNCT
admet-1034	384	4	z.	z.	PROPN
admet-1034	384	5	chen	chen	PROPN
admet-1034	384	6	,	,	PUNCT
admet-1034	384	7	s.g	s.g	PROPN
admet-1034	384	8	.	.	PROPN
admet-1034	384	9	weber	weber	PROPN
admet-1034	384	10	.	.	PUNCT
admet-1034	385	1	high	high	ADJ
admet-1034	385	2	-	-	PUNCT
admet-1034	385	3	throughput	throughput	NOUN
admet-1034	385	4	method	method	NOUN
admet-1034	385	5	for	for	ADP
admet-1034	385	6	lipophilicity	lipophilicity	NOUN
admet-1034	385	7	measurement	measurement	NOUN
admet-1034	385	8	.	.	PUNCT
admet-1034	386	1	anal	anal	PROPN
admet-1034	386	2	.	.	PUNCT
admet-1034	386	3	chem	chem	PROPN
admet-1034	386	4	.	.	PUNCT
admet-1034	387	1	79	79	NUM
admet-1034	387	2	(	(	PUNCT
admet-1034	387	3	2007	2007	NUM
admet-1034	387	4	)	)	PUNCT
admet-1034	387	5	1043	1043	NUM
admet-1034	387	6	-	-	SYM
admet-1034	387	7	1049	1049	NUM
admet-1034	387	8	.	.	PUNCT
admet-1034	388	1	https://dx.doi.org/10.1021/ac061649a	https://dx.doi.org/10.1021/ac061649a	INTJ
admet-1034	388	2	.	.	PUNCT
admet-1034	389	1	[	[	X
admet-1034	389	2	43	43	NUM
admet-1034	389	3	]	]	X
admet-1034	389	4	p.	p.	PROPN
admet-1034	389	5	jeffrey	jeffrey	PROPN
admet-1034	389	6	,	,	PUNCT
admet-1034	389	7	s.g	s.g	PROPN
admet-1034	389	8	.	.	PROPN
admet-1034	389	9	summerfield	summerfield	PROPN
admet-1034	389	10	.	.	PUNCT
admet-1034	390	1	challenges	challenge	NOUN
admet-1034	390	2	for	for	ADP
admet-1034	390	3	blood	blood	NOUN
admet-1034	390	4	-	-	PUNCT
admet-1034	390	5	brain	brain	NOUN
admet-1034	390	6	barrier	barrier	NOUN
admet-1034	390	7	(	(	PUNCT
admet-1034	390	8	bbb	bbb	NOUN
admet-1034	390	9	)	)	PUNCT
admet-1034	390	10	screening	screening	NOUN
admet-1034	390	11	.	.	PUNCT
admet-1034	391	1	xenobiotica	xenobiotica	PROPN
admet-1034	391	2	37	37	NUM
admet-1034	391	3	(	(	PUNCT
admet-1034	391	4	2007	2007	NUM
admet-1034	391	5	)	)	PUNCT
admet-1034	391	6	1135	1135	NUM
admet-1034	391	7	-	-	SYM
admet-1034	391	8	1151	1151	NUM
admet-1034	391	9	.	.	PUNCT
admet-1034	392	1	https://dx.doi.org/10.1080/00498250701570285	https://dx.doi.org/10.1080/00498250701570285	PROPN
admet-1034	392	2	.	.	PUNCT
admet-1034	393	1	[	[	X
admet-1034	393	2	44	44	NUM
admet-1034	393	3	]	]	X
admet-1034	393	4	j.m	j.m	PROPN
admet-1034	393	5	.	.	PROPN
admet-1034	393	6	diamond	diamond	PROPN
admet-1034	393	7	,	,	PUNCT
admet-1034	393	8	e.m	e.m	PROPN
admet-1034	393	9	.	.	PROPN
admet-1034	393	10	wright	wright	PROPN
admet-1034	393	11	,	,	PUNCT
admet-1034	393	12	d.h	d.h	PROPN
admet-1034	393	13	.	.	PROPN
admet-1034	393	14	smyth	smyth	PROPN
admet-1034	393	15	.	.	PUNCT
admet-1034	394	1	molecular	molecular	ADJ
admet-1034	394	2	forces	force	NOUN
admet-1034	394	3	governing	govern	VERB
admet-1034	394	4	non	non	ADJ
admet-1034	394	5	-	-	ADJ
admet-1034	394	6	electrolyte	electrolyte	ADJ
admet-1034	394	7	permeation	permeation	NOUN
admet-1034	394	8	through	through	ADP
admet-1034	394	9	cell	cell	NOUN
admet-1034	394	10	membranes	membrane	NOUN
admet-1034	394	11	.	.	PUNCT
admet-1034	395	1	proceedings	proceeding	NOUN
admet-1034	395	2	of	of	ADP
admet-1034	395	3	the	the	DET
admet-1034	395	4	royal	royal	ADJ
admet-1034	395	5	society	society	NOUN
admet-1034	395	6	of	of	ADP
admet-1034	395	7	london	london	PROPN
admet-1034	395	8	.	.	PUNCT
admet-1034	396	1	series	series	PROPN
admet-1034	396	2	b.	b.	PROPN
admet-1034	396	3	biological	biological	PROPN
admet-1034	396	4	sciences	sciences	PROPN
admet-1034	396	5	172	172	NUM
admet-1034	396	6	(	(	PUNCT
admet-1034	396	7	1969	1969	NUM
admet-1034	396	8	)	)	PUNCT
admet-1034	396	9	273	273	NUM
admet-1034	396	10	-	-	SYM
admet-1034	396	11	316	316	NUM
admet-1034	396	12	.	.	PUNCT
admet-1034	396	13	https://dx.doi.org/10.1098/rspb.1969.0022	https://dx.doi.org/10.1098/rspb.1969.0022	NOUN
admet-1034	396	14	.	.	PUNCT
admet-1034	397	1	[	[	X
admet-1034	397	2	45	45	NUM
admet-1034	397	3	]	]	PUNCT
admet-1034	397	4	e.g.	e.g.	ADV
admet-1034	397	5	chikhale	chikhale	ADJ
admet-1034	397	6	,	,	PUNCT
admet-1034	397	7	k.-y	k.-y	NOUN
admet-1034	397	8	.	.	PUNCT
admet-1034	398	1	ng	ng	PROPN
admet-1034	398	2	,	,	PUNCT
admet-1034	398	3	p.s	p.s	PROPN
admet-1034	398	4	.	.	PROPN
admet-1034	398	5	burton	burton	PROPN
admet-1034	398	6	,	,	PUNCT
admet-1034	398	7	r.t	r.t	PROPN
admet-1034	398	8	.	.	PROPN
admet-1034	398	9	borchardt	borchardt	PROPN
admet-1034	398	10	.	.	PUNCT
admet-1034	399	1	hydrogen	hydrogen	NOUN
admet-1034	399	2	bonding	bonding	NOUN
admet-1034	399	3	potential	potential	NOUN
admet-1034	399	4	as	as	ADP
admet-1034	399	5	a	a	DET
admet-1034	399	6	determinant	determinant	NOUN
admet-1034	399	7	of	of	ADP
admet-1034	399	8	the	the	DET
admet-1034	399	9	in	in	ADP
admet-1034	399	10	vitro	vitro	X
admet-1034	399	11	and	and	CCONJ
admet-1034	399	12	in	in	ADP
admet-1034	399	13	situ	situ	ADJ
admet-1034	399	14	blood	blood	NOUN
admet-1034	399	15	–	–	PUNCT
admet-1034	399	16	brain	brain	NOUN
admet-1034	399	17	barrier	barrier	NOUN
admet-1034	399	18	permeability	permeability	NOUN
admet-1034	399	19	of	of	ADP
admet-1034	399	20	peptides	peptide	NOUN
admet-1034	399	21	.	.	PUNCT
admet-1034	400	1	pharmaceutical	pharmaceutical	ADJ
admet-1034	400	2	research	research	NOUN
admet-1034	400	3	11	11	NUM
admet-1034	400	4	(	(	PUNCT
admet-1034	400	5	1994	1994	NUM
admet-1034	400	6	)	)	PUNCT
admet-1034	400	7	412	412	NUM
admet-1034	400	8	-	-	SYM
admet-1034	400	9	419	419	NUM
admet-1034	400	10	.	.	PUNCT
admet-1034	401	1	https://dx.doi.org/10.1023/a:1018969222130	https://dx.doi.org/10.1023/a:1018969222130	PROPN
admet-1034	401	2	.	.	PUNCT
admet-1034	402	1	©	©	PROPN
admet-1034	402	2	2021	2021	NUM
admet-1034	402	3	by	by	ADP
admet-1034	402	4	the	the	DET
admet-1034	402	5	authors	author	NOUN
admet-1034	402	6	;	;	PUNCT
admet-1034	402	7	licensee	licensee	PROPN
admet-1034	402	8	iapc	iapc	PROPN
admet-1034	402	9	,	,	PUNCT
admet-1034	402	10	zagreb	zagreb	PROPN
admet-1034	402	11	,	,	PUNCT
admet-1034	402	12	croatia	croatia	PROPN
admet-1034	402	13	.	.	PUNCT
admet-1034	403	1	this	this	DET
admet-1034	403	2	article	article	NOUN
admet-1034	403	3	is	be	AUX
admet-1034	403	4	an	an	DET
admet-1034	403	5	open	open	ADJ
admet-1034	403	6	-	-	PUNCT
admet-1034	403	7	access	access	NOUN
admet-1034	403	8	article	article	NOUN
admet-1034	403	9	distributed	distribute	VERB
admet-1034	403	10	under	under	ADP
admet-1034	403	11	the	the	DET
admet-1034	403	12	terms	term	NOUN
admet-1034	403	13	and	and	CCONJ
admet-1034	403	14	conditions	condition	NOUN
admet-1034	403	15	of	of	ADP
admet-1034	403	16	the	the	DET
admet-1034	403	17	creative	creative	ADJ
admet-1034	403	18	commons	common	NOUN
admet-1034	403	19	attribution	attribution	NOUN
admet-1034	403	20	license	license	NOUN
admet-1034	403	21	(	(	PUNCT
admet-1034	403	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1034	403	23	)	)	PUNCT
admet-1034	403	24	http://dx.doi.org/10.5599/admet.1034	http://dx.doi.org/10.5599/admet.1034	VERB
admet-1034	404	1	https://dx.doi.org/10.1517/17460441.2016.1160886	https://dx.doi.org/10.1517/17460441.2016.1160886	VERB
admet-1034	404	2	https://dx.doi.org/10.1002/1522-2675(200202)85:2%3c519::aid-hlca519%3e3.0.co;2-q	https://dx.doi.org/10.1002/1522-2675(200202)85:2%3c519::aid-hlca519%3e3.0.co;2-q	PROPN
admet-1034	404	3	https://dx.doi.org/10.1002/1522-2675(200202)85:2%3c519::aid-hlca519%3e3.0.co;2-q	https://dx.doi.org/10.1002/1522-2675(200202)85:2%3c519::aid-hlca519%3e3.0.co;2-q	PROPN
admet-1034	404	4	https://dx.doi.org/10.1517/17460441.2012.714363	https://dx.doi.org/10.1517/17460441.2012.714363	ADJ
admet-1034	404	5	https://dx.doi.org/10.2174/138620709787581701	https://dx.doi.org/10.2174/138620709787581701	NOUN
admet-1034	404	6	https://dx.doi.org/10.1021/ac061649a	https://dx.doi.org/10.1021/ac061649a	PROPN
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admet-1034	404	8	https://dx.doi.org/10.1098/rspb.1969.0022	https://dx.doi.org/10.1098/rspb.1969.0022	PROPN
admet-1034	404	9	https://dx.doi.org/10.1023/a:1018969222130	https://dx.doi.org/10.1023/a:1018969222130	PROPN
admet-1034	404	10	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN