id	sid	tid	token	lemma	pos
admet-1037	1	1	are	be	AUX
admet-1037	1	2	we	we	PRON
admet-1037	1	3	ready	ready	ADJ
admet-1037	1	4	to	to	PART
admet-1037	1	5	design	design	VERB
admet-1037	1	6	oral	oral	ADJ
admet-1037	1	7	protacs	protacs	PROPN
admet-1037	1	8	®	®	NOUN
admet-1037	1	9	?	?	PUNCT
admet-1037	2	1	doi	doi	NOUN
admet-1037	2	2	:	:	PUNCT
admet-1037	2	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	NUM
admet-1037	2	4	243	243	NUM
admet-1037	2	5	admet	admet	X
admet-1037	2	6	&	&	CCONJ
admet-1037	2	7	dmpk	dmpk	PROPN
admet-1037	2	8	9(4	9(4	PROPN
admet-1037	2	9	)	)	PUNCT
admet-1037	2	10	(	(	PUNCT
admet-1037	2	11	2021	2021	NUM
admet-1037	2	12	)	)	PUNCT
admet-1037	2	13	243	243	NUM
admet-1037	2	14	-	-	SYM
admet-1037	2	15	254	254	NUM
admet-1037	2	16	;	;	PUNCT
admet-1037	2	17	doi	doi	NOUN
admet-1037	2	18	:	:	PUNCT
admet-1037	2	19	https://doi.org/10.5599/admet.1037	https://doi.org/10.5599/admet.1037	NOUN
admet-1037	2	20	open	open	ADJ
admet-1037	2	21	access	access	NOUN
admet-1037	2	22	:	:	PUNCT
admet-1037	2	23	issn	issn	PROPN
admet-1037	2	24	:	:	PUNCT
admet-1037	2	25	1848	1848	NUM
admet-1037	2	26	-	-	SYM
admet-1037	2	27	7718	7718	NUM
admet-1037	2	28	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1037	2	29	original	original	ADJ
admet-1037	2	30	scientific	scientific	ADJ
admet-1037	2	31	paper	paper	NOUN
admet-1037	2	32	are	be	AUX
admet-1037	2	33	we	we	PRON
admet-1037	2	34	ready	ready	ADJ
admet-1037	2	35	to	to	PART
admet-1037	2	36	design	design	VERB
admet-1037	2	37	oral	oral	ADJ
admet-1037	2	38	protacs	protacs	PROPN
admet-1037	2	39	®	®	NOUN
admet-1037	2	40	?	?	PUNCT
admet-1037	3	1	diego	diego	PROPN
admet-1037	3	2	garcia	garcia	PROPN
admet-1037	3	3	jimenez	jimenez	PROPN
admet-1037	3	4	,	,	PUNCT
admet-1037	3	5	matteo	matteo	PROPN
admet-1037	3	6	rossi	rossi	PROPN
admet-1037	3	7	sebastiano	sebastiano	PROPN
admet-1037	3	8	,	,	PUNCT
admet-1037	3	9	giulia	giulia	PROPN
admet-1037	3	10	caron	caron	PROPN
admet-1037	3	11	,	,	PUNCT
admet-1037	3	12	giuseppe	giuseppe	PROPN
admet-1037	3	13	ermondi	ermondi	PROPN
admet-1037	3	14	*	*	PROPN
admet-1037	3	15	university	university	PROPN
admet-1037	3	16	of	of	ADP
admet-1037	3	17	torino	torino	NOUN
admet-1037	3	18	,	,	PUNCT
admet-1037	3	19	molecular	molecular	ADJ
admet-1037	3	20	biotechnology	biotechnology	NOUN
admet-1037	3	21	and	and	CCONJ
admet-1037	3	22	health	health	NOUN
admet-1037	3	23	sciences	sciences	PROPN
admet-1037	3	24	dept	dept	PROPN
admet-1037	3	25	.	.	PROPN
admet-1037	3	26	,	,	PUNCT
admet-1037	3	27	cassmedchem	cassmedchem	PROPN
admet-1037	3	28	,	,	PUNCT
admet-1037	3	29	via	via	ADP
admet-1037	3	30	quarello	quarello	PROPN
admet-1037	3	31	15	15	NUM
admet-1037	3	32	,	,	PUNCT
admet-1037	3	33	10135	10135	NUM
admet-1037	3	34	torino	torino	NOUN
admet-1037	3	35	,	,	PUNCT
admet-1037	3	36	italy	italy	PROPN
admet-1037	3	37	.	.	PUNCT
admet-1037	4	1	*	*	PUNCT
admet-1037	4	2	giuseppe	giuseppe	PROPN
admet-1037	4	3	ermondi	ermondi	PROPN
admet-1037	4	4	:	:	PUNCT
admet-1037	4	5	e	e	X
admet-1037	4	6	-	-	NOUN
admet-1037	4	7	mail	mail	NOUN
admet-1037	4	8	:	:	PUNCT
admet-1037	4	9	giuseppe.ermondi@unito.it	giuseppe.ermondi@unito.it	PROPN
admet-1037	4	10	;	;	PUNCT
admet-1037	5	1	tel	tel	PROPN
admet-1037	5	2	.	.	PUNCT
admet-1037	5	3	:	:	PUNCT
admet-1037	6	1	+39	+39	PROPN
admet-1037	6	2	011	011	NUM
admet-1037	6	3	6708337	6708337	NUM
admet-1037	6	4	received	receive	VERB
admet-1037	6	5	:	:	PUNCT
admet-1037	6	6	june	june	PROPN
admet-1037	6	7	29	29	NUM
admet-1037	6	8	,	,	PUNCT
admet-1037	6	9	2021	2021	NUM
admet-1037	6	10	;	;	PUNCT
admet-1037	6	11	revised	revise	VERB
admet-1037	6	12	:	:	PUNCT
admet-1037	6	13	august	august	PROPN
admet-1037	6	14	22	22	NUM
admet-1037	6	15	,	,	PUNCT
admet-1037	6	16	2021	2021	NUM
admet-1037	6	17	;	;	PUNCT
admet-1037	6	18	available	available	ADJ
admet-1037	6	19	online	online	NOUN
admet-1037	6	20	:	:	PUNCT
admet-1037	6	21	august	august	PROPN
admet-1037	6	22	31	31	NUM
admet-1037	6	23	,	,	PUNCT
admet-1037	6	24	2021	2021	NUM
admet-1037	6	25	abstract	abstract	ADJ
admet-1037	6	26	protacs	protac	NOUN
admet-1037	6	27	®	®	NOUN
admet-1037	6	28	are	be	AUX
admet-1037	6	29	expected	expect	VERB
admet-1037	6	30	to	to	PART
admet-1037	6	31	strongly	strongly	ADV
admet-1037	6	32	impact	impact	VERB
admet-1037	6	33	the	the	DET
admet-1037	6	34	future	future	NOUN
admet-1037	6	35	of	of	ADP
admet-1037	6	36	drug	drug	NOUN
admet-1037	6	37	discovery	discovery	NOUN
admet-1037	6	38	.	.	PUNCT
admet-1037	7	1	therefore	therefore	ADV
admet-1037	7	2	,	,	PUNCT
admet-1037	7	3	in	in	ADP
admet-1037	7	4	this	this	DET
admet-1037	7	5	work	work	NOUN
admet-1037	7	6	we	we	PRON
admet-1037	7	7	firstly	firstly	ADV
admet-1037	7	8	performed	perform	VERB
admet-1037	7	9	a	a	DET
admet-1037	7	10	statistical	statistical	ADJ
admet-1037	7	11	study	study	NOUN
admet-1037	7	12	to	to	PART
admet-1037	7	13	highlight	highlight	VERB
admet-1037	7	14	the	the	DET
admet-1037	7	15	distribution	distribution	NOUN
admet-1037	7	16	of	of	ADP
admet-1037	7	17	e3	e3	NOUN
admet-1037	7	18	ligases	ligase	NOUN
admet-1037	7	19	and	and	CCONJ
admet-1037	7	20	pois	pois	NOUN
admet-1037	7	21	collected	collect	VERB
admet-1037	7	22	in	in	ADP
admet-1037	7	23	protac	protac	ADJ
admet-1037	7	24	-	-	PUNCT
admet-1037	7	25	db	db	NOUN
admet-1037	7	26	,	,	PUNCT
admet-1037	7	27	the	the	DET
admet-1037	7	28	main	main	ADJ
admet-1037	7	29	online	online	ADJ
admet-1037	7	30	database	database	NOUN
admet-1037	7	31	focused	focus	VERB
admet-1037	7	32	on	on	ADP
admet-1037	7	33	degraders	degrader	NOUN
admet-1037	7	34	.	.	PUNCT
admet-1037	8	1	moreover	moreover	ADV
admet-1037	8	2	,	,	PUNCT
admet-1037	8	3	since	since	SCONJ
admet-1037	8	4	the	the	DET
admet-1037	8	5	emerging	emerge	VERB
admet-1037	8	6	technology	technology	NOUN
admet-1037	8	7	of	of	ADP
admet-1037	8	8	protein	protein	NOUN
admet-1037	8	9	degradation	degradation	NOUN
admet-1037	8	10	deals	deal	NOUN
admet-1037	8	11	with	with	ADP
admet-1037	8	12	large	large	ADJ
admet-1037	8	13	and	and	CCONJ
admet-1037	8	14	complex	complex	ADJ
admet-1037	8	15	chemical	chemical	NOUN
admet-1037	8	16	structures	structure	NOUN
admet-1037	8	17	,	,	PUNCT
admet-1037	8	18	the	the	DET
admet-1037	8	19	second	second	ADJ
admet-1037	8	20	part	part	NOUN
admet-1037	8	21	of	of	ADP
admet-1037	8	22	the	the	DET
admet-1037	8	23	paper	paper	NOUN
admet-1037	8	24	focuses	focus	VERB
admet-1037	8	25	on	on	ADP
admet-1037	8	26	how	how	SCONJ
admet-1037	8	27	to	to	PART
admet-1037	8	28	set	set	VERB
admet-1037	8	29	up	up	ADP
admet-1037	8	30	a	a	DET
admet-1037	8	31	property	property	NOUN
admet-1037	8	32	-	-	PUNCT
admet-1037	8	33	based	base	VERB
admet-1037	8	34	design	design	NOUN
admet-1037	8	35	strategy	strategy	NOUN
admet-1037	8	36	to	to	PART
admet-1037	8	37	obtain	obtain	VERB
admet-1037	8	38	oral	oral	ADJ
admet-1037	8	39	degraders	degrader	NOUN
admet-1037	8	40	.	.	PUNCT
admet-1037	9	1	for	for	ADP
admet-1037	9	2	this	this	DET
admet-1037	9	3	purpose	purpose	NOUN
admet-1037	9	4	,	,	PUNCT
admet-1037	9	5	we	we	PRON
admet-1037	9	6	calculated	calculate	VERB
admet-1037	9	7	a	a	DET
admet-1037	9	8	pool	pool	NOUN
admet-1037	9	9	of	of	ADP
admet-1037	9	10	seven	seven	NUM
admet-1037	9	11	previously	previously	ADV
admet-1037	9	12	ad	ad	X
admet-1037	9	13	hoc	hoc	X
admet-1037	9	14	selected	select	VERB
admet-1037	9	15	2d	2d	NUM
admet-1037	9	16	descriptors	descriptor	NOUN
admet-1037	9	17	for	for	ADP
admet-1037	9	18	the	the	DET
admet-1037	9	19	2258	2258	NUM
admet-1037	9	20	publicly	publicly	ADV
admet-1037	9	21	available	available	ADJ
admet-1037	9	22	degraders	degrader	NOUN
admet-1037	9	23	in	in	ADP
admet-1037	9	24	protac	protac	ADJ
admet-1037	9	25	-	-	PUNCT
admet-1037	9	26	db	db	NOUN
admet-1037	9	27	(	(	PUNCT
admet-1037	9	28	average	average	ADJ
admet-1037	9	29	values	value	NOUN
admet-1037	9	30	:	:	PUNCT
admet-1037	9	31	mw=	mw=	NOUN
admet-1037	9	32	972.9	972.9	NUM
admet-1037	9	33	da	da	NOUN
admet-1037	9	34	,	,	PUNCT
admet-1037	9	35	nc=	nc=	NOUN
admet-1037	9	36	49.5	49.5	NUM
admet-1037	9	37	,	,	PUNCT
admet-1037	9	38	nar=	nar=	PROPN
admet-1037	9	39	4.5	4.5	NUM
admet-1037	9	40	,	,	PUNCT
admet-1037	9	41	phi=	phi=	PROPN
admet-1037	9	42	17.3	17.3	NUM
admet-1037	9	43	,	,	PUNCT
admet-1037	9	44	nhdon=	nhdon=	NUM
admet-1037	9	45	4.5	4.5	NUM
admet-1037	9	46	,	,	PUNCT
admet-1037	9	47	nhacc=	nhacc=	PROPN
admet-1037	9	48	17.7	17.7	NUM
admet-1037	9	49	and	and	CCONJ
admet-1037	9	50	tpsa=	tpsa=	NUM
admet-1037	9	51	240	240	NUM
admet-1037	9	52	å	å	PROPN
admet-1037	9	53	2	2	NUM
admet-1037	9	54	)	)	PUNCT
admet-1037	9	55	and	and	CCONJ
admet-1037	9	56	compared	compare	VERB
admet-1037	9	57	them	they	PRON
admet-1037	9	58	to	to	ADP
admet-1037	9	59	a	a	DET
admet-1037	9	60	dataset	dataset	NOUN
admet-1037	9	61	of	of	ADP
admet-1037	9	62	50	50	NUM
admet-1037	9	63	bro5	bro5	NOUN
admet-1037	9	64	orally	orally	ADV
admet-1037	9	65	approved	approve	VERB
admet-1037	9	66	drugs	drug	NOUN
admet-1037	9	67	.	.	PUNCT
admet-1037	10	1	then	then	ADV
admet-1037	10	2	,	,	PUNCT
admet-1037	10	3	a	a	DET
admet-1037	10	4	chemical	chemical	NOUN
admet-1037	10	5	space	space	NOUN
admet-1037	10	6	based	base	VERB
admet-1037	10	7	on	on	ADP
admet-1037	10	8	nc	nc	PROPN
admet-1037	10	9	,	,	PUNCT
admet-1037	10	10	phi	phi	NOUN
admet-1037	10	11	and	and	CCONJ
admet-1037	10	12	tpsa	tpsa	NOUN
admet-1037	10	13	was	be	AUX
admet-1037	10	14	built	build	VERB
admet-1037	10	15	and	and	CCONJ
admet-1037	10	16	subregions	subregion	NOUN
admet-1037	10	17	with	with	ADP
admet-1037	10	18	optimal	optimal	ADJ
admet-1037	10	19	permeability	permeability	NOUN
admet-1037	10	20	and	and	CCONJ
admet-1037	10	21	bioavailability	bioavailability	NOUN
admet-1037	10	22	were	be	AUX
admet-1037	10	23	identified	identify	VERB
admet-1037	10	24	.	.	PUNCT
admet-1037	11	1	bioavailable	bioavailable	ADJ
admet-1037	11	2	degraders	degrader	NOUN
admet-1037	11	3	(	(	PUNCT
admet-1037	11	4	arv-110	arv-110	ADJ
admet-1037	11	5	and	and	CCONJ
admet-1037	11	6	arv-471	arv-471	NOUN
admet-1037	11	7	)	)	PUNCT
admet-1037	11	8	tend	tend	VERB
admet-1037	11	9	to	to	PART
admet-1037	11	10	be	be	AUX
admet-1037	11	11	closer	close	ADJ
admet-1037	11	12	to	to	ADP
admet-1037	11	13	the	the	DET
admet-1037	11	14	ro5	ro5	ADJ
admet-1037	11	15	region	region	NOUN
admet-1037	11	16	,	,	PUNCT
admet-1037	11	17	using	use	VERB
admet-1037	11	18	mainly	mainly	ADV
admet-1037	11	19	semi	semi	ADJ
admet-1037	11	20	-	-	ADJ
admet-1037	11	21	rigid	rigid	ADJ
admet-1037	11	22	linkers	linker	NOUN
admet-1037	11	23	.	.	PUNCT
admet-1037	12	1	permeable	permeable	ADJ
admet-1037	12	2	degraders	degrader	NOUN
admet-1037	12	3	,	,	PUNCT
admet-1037	12	4	on	on	ADP
admet-1037	12	5	the	the	DET
admet-1037	12	6	other	other	ADJ
admet-1037	12	7	hand	hand	NOUN
admet-1037	12	8	,	,	PUNCT
admet-1037	12	9	are	be	AUX
admet-1037	12	10	placed	place	VERB
admet-1037	12	11	in	in	ADP
admet-1037	12	12	an	an	DET
admet-1037	12	13	average	average	ADJ
admet-1037	12	14	central	central	ADJ
admet-1037	12	15	region	region	NOUN
admet-1037	12	16	of	of	ADP
admet-1037	12	17	the	the	DET
admet-1037	12	18	chemical	chemical	NOUN
admet-1037	12	19	space	space	NOUN
admet-1037	12	20	but	but	CCONJ
admet-1037	12	21	chameleonicity	chameleonicity	NOUN
admet-1037	12	22	could	could	AUX
admet-1037	12	23	allow	allow	VERB
admet-1037	12	24	them	they	PRON
admet-1037	12	25	to	to	PART
admet-1037	12	26	be	be	AUX
admet-1037	12	27	located	locate	VERB
admet-1037	12	28	closer	close	ADV
admet-1037	12	29	to	to	ADP
admet-1037	12	30	the	the	DET
admet-1037	12	31	two	two	NUM
admet-1037	12	32	arvinas	arvinas	NOUN
admet-1037	12	33	compounds	compound	NOUN
admet-1037	12	34	.	.	PUNCT
admet-1037	13	1	©	©	NOUN
admet-1037	13	2	2021	2021	NUM
admet-1037	13	3	by	by	ADP
admet-1037	13	4	the	the	DET
admet-1037	13	5	authors	author	NOUN
admet-1037	13	6	.	.	PUNCT
admet-1037	14	1	this	this	DET
admet-1037	14	2	article	article	NOUN
admet-1037	14	3	is	be	AUX
admet-1037	14	4	an	an	DET
admet-1037	14	5	open	open	ADJ
admet-1037	14	6	-	-	PUNCT
admet-1037	14	7	access	access	NOUN
admet-1037	14	8	article	article	NOUN
admet-1037	14	9	distributed	distribute	VERB
admet-1037	14	10	under	under	ADP
admet-1037	14	11	the	the	DET
admet-1037	14	12	terms	term	NOUN
admet-1037	14	13	and	and	CCONJ
admet-1037	14	14	conditions	condition	NOUN
admet-1037	14	15	of	of	ADP
admet-1037	14	16	the	the	DET
admet-1037	14	17	creative	creative	ADJ
admet-1037	14	18	commons	common	NOUN
admet-1037	14	19	attribution	attribution	NOUN
admet-1037	14	20	license	license	NOUN
admet-1037	14	21	(	(	PUNCT
admet-1037	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1037	14	23	)	)	PUNCT
admet-1037	14	24	.	.	PUNCT
admet-1037	15	1	keywords	keyword	NOUN
admet-1037	15	2	degrader	degrader	NOUN
admet-1037	15	3	;	;	PUNCT
admet-1037	15	4	bro5	bro5	NOUN
admet-1037	15	5	;	;	PUNCT
admet-1037	15	6	bioavailability	bioavailability	NOUN
admet-1037	15	7	;	;	PUNCT
admet-1037	15	8	permeability	permeability	NOUN
admet-1037	15	9	;	;	PUNCT
admet-1037	15	10	chemical	chemical	NOUN
admet-1037	15	11	space	space	NOUN
admet-1037	15	12	;	;	PUNCT
admet-1037	15	13	protac	protac	ADJ
admet-1037	15	14	-	-	PUNCT
admet-1037	15	15	db	db	NOUN
admet-1037	15	16	;	;	PUNCT
admet-1037	15	17	chameleonicity	chameleonicity	NOUN
admet-1037	15	18	.	.	PUNCT
admet-1037	16	1	introduction	introduction	NOUN
admet-1037	16	2	traditionally	traditionally	ADV
admet-1037	16	3	,	,	PUNCT
admet-1037	16	4	the	the	DET
admet-1037	16	5	search	search	NOUN
admet-1037	16	6	for	for	ADP
admet-1037	16	7	novel	novel	ADJ
admet-1037	16	8	treatments	treatment	NOUN
admet-1037	16	9	has	have	AUX
admet-1037	16	10	been	be	AUX
admet-1037	16	11	undoubtedly	undoubtedly	ADV
admet-1037	16	12	driven	drive	VERB
admet-1037	16	13	by	by	ADP
admet-1037	16	14	small	small	ADJ
admet-1037	16	15	molecule	molecule	NOUN
admet-1037	16	16	discovery	discovery	NOUN
admet-1037	16	17	.	.	PUNCT
admet-1037	17	1	however	however	ADV
admet-1037	17	2	,	,	PUNCT
admet-1037	17	3	since	since	SCONJ
admet-1037	17	4	the	the	DET
admet-1037	17	5	release	release	NOUN
admet-1037	17	6	of	of	ADP
admet-1037	17	7	muromonab	muromonab	NOUN
admet-1037	17	8	in	in	ADP
admet-1037	17	9	1986	1986	NUM
admet-1037	17	10	,	,	PUNCT
admet-1037	17	11	biologics	biologic	NOUN
admet-1037	17	12	have	have	AUX
admet-1037	17	13	gained	gain	VERB
admet-1037	17	14	importance	importance	NOUN
admet-1037	17	15	.	.	PUNCT
admet-1037	18	1	even	even	ADV
admet-1037	18	2	though	though	SCONJ
admet-1037	18	3	the	the	DET
admet-1037	18	4	market	market	NOUN
admet-1037	18	5	impact	impact	NOUN
admet-1037	18	6	for	for	ADP
admet-1037	18	7	this	this	DET
admet-1037	18	8	class	class	NOUN
admet-1037	18	9	of	of	ADP
admet-1037	18	10	molecules	molecule	NOUN
admet-1037	18	11	was	be	AUX
admet-1037	18	12	predicted	predict	VERB
admet-1037	18	13	to	to	PART
admet-1037	18	14	rise	rise	VERB
admet-1037	18	15	faster	fast	ADV
admet-1037	18	16	,	,	PUNCT
admet-1037	18	17	71	71	NUM
admet-1037	18	18	%	%	NOUN
admet-1037	18	19	of	of	ADP
admet-1037	18	20	2020s	2020	NOUN
admet-1037	18	21	approved	approve	VERB
admet-1037	18	22	drugs	drug	NOUN
admet-1037	18	23	(	(	PUNCT
admet-1037	18	24	38	38	NUM
admet-1037	18	25	)	)	PUNCT
admet-1037	18	26	correspond	correspond	VERB
admet-1037	18	27	to	to	ADP
admet-1037	18	28	small	small	ADJ
admet-1037	18	29	molecules	molecule	NOUN
admet-1037	18	30	which	which	PRON
admet-1037	18	31	still	still	ADV
admet-1037	18	32	assume	assume	VERB
admet-1037	18	33	,	,	PUNCT
admet-1037	18	34	35	35	NUM
admet-1037	18	35	years	year	NOUN
admet-1037	18	36	later	later	ADV
admet-1037	18	37	,	,	PUNCT
admet-1037	18	38	the	the	DET
admet-1037	18	39	burden	burden	NOUN
admet-1037	18	40	of	of	ADP
admet-1037	18	41	drug	drug	NOUN
admet-1037	18	42	discovery	discovery	NOUN
admet-1037	18	43	research	research	NOUN
admet-1037	18	44	(	(	PUNCT
admet-1037	18	45	www.fda.gov	www.fda.gov	NOUN
admet-1037	18	46	)	)	PUNCT
admet-1037	18	47	.	.	PUNCT
admet-1037	19	1	moreover	moreover	ADV
admet-1037	19	2	,	,	PUNCT
admet-1037	19	3	the	the	DET
admet-1037	19	4	guidelines	guideline	NOUN
admet-1037	19	5	for	for	ADP
admet-1037	19	6	small	small	ADJ
admet-1037	19	7	molecule	molecule	NOUN
admet-1037	19	8	development	development	NOUN
admet-1037	19	9	have	have	AUX
admet-1037	19	10	evolved	evolve	VERB
admet-1037	19	11	from	from	ADP
admet-1037	19	12	the	the	DET
admet-1037	19	13	traditional	traditional	ADJ
admet-1037	19	14	agonism	agonism	NOUN
admet-1037	19	15	-	-	PUNCT
admet-1037	19	16	antagonism	antagonism	NOUN
admet-1037	19	17	concept	concept	NOUN
admet-1037	19	18	to	to	ADP
admet-1037	19	19	innovative	innovative	ADJ
admet-1037	19	20	mechanisms	mechanism	NOUN
admet-1037	19	21	of	of	ADP
admet-1037	19	22	action	action	NOUN
admet-1037	19	23	.	.	PUNCT
admet-1037	20	1	thus	thus	ADV
admet-1037	20	2	,	,	PUNCT
admet-1037	20	3	small	small	ADJ
admet-1037	20	4	molecule	molecule	NOUN
admet-1037	20	5	research	research	NOUN
admet-1037	20	6	has	have	AUX
admet-1037	20	7	enlarged	enlarge	VERB
admet-1037	20	8	its	its	PRON
admet-1037	20	9	scope	scope	NOUN
admet-1037	20	10	to	to	ADP
admet-1037	20	11	nucleic	nucleic	ADJ
admet-1037	20	12	acid	acid	NOUN
admet-1037	20	13	-	-	PUNCT
admet-1037	20	14	based	base	VERB
admet-1037	20	15	modalities	modality	NOUN
admet-1037	20	16	,	,	PUNCT
admet-1037	20	17	protein	protein	NOUN
admet-1037	20	18	-	-	PUNCT
admet-1037	20	19	protein	protein	NOUN
admet-1037	20	20	interaction	interaction	NOUN
admet-1037	20	21	(	(	PUNCT
admet-1037	20	22	ppi	ppi	NOUN
admet-1037	20	23	)	)	PUNCT
admet-1037	20	24	modulators	modulator	NOUN
admet-1037	20	25	,	,	PUNCT
admet-1037	20	26	peptide	peptide	NOUN
admet-1037	20	27	/	/	SYM
admet-1037	20	28	peptidomimetics	peptidomimetic	NOUN
admet-1037	20	29	and	and	CCONJ
admet-1037	20	30	protacs	protac	NOUN
admet-1037	20	31	®	®	NOUN
admet-1037	20	32	or	or	CCONJ
admet-1037	20	33	degraders	degrader	VERB
admet-1037	20	34	[	[	X
admet-1037	20	35	1	1	NUM
admet-1037	20	36	]	]	PUNCT
admet-1037	20	37	.	.	PUNCT
admet-1037	21	1	in	in	ADP
admet-1037	21	2	particular	particular	ADJ
admet-1037	21	3	,	,	PUNCT
admet-1037	21	4	protacs	protac	NOUN
admet-1037	21	5	®	®	NOUN
admet-1037	21	6	have	have	AUX
admet-1037	21	7	been	be	AUX
admet-1037	21	8	revealed	reveal	VERB
admet-1037	21	9	to	to	PART
admet-1037	21	10	be	be	AUX
admet-1037	21	11	a	a	DET
admet-1037	21	12	promising	promising	ADJ
admet-1037	21	13	therapeutic	therapeutic	ADJ
admet-1037	21	14	area	area	NOUN
admet-1037	21	15	,	,	PUNCT
admet-1037	21	16	which	which	PRON
admet-1037	21	17	has	have	AUX
admet-1037	21	18	expanded	expand	VERB
admet-1037	21	19	from	from	ADP
admet-1037	21	20	13	13	NUM
admet-1037	21	21	scientific	scientific	ADJ
admet-1037	21	22	articles	article	NOUN
admet-1037	21	23	in	in	ADP
admet-1037	21	24	2016	2016	NUM
admet-1037	21	25	to	to	ADP
admet-1037	21	26	265	265	NUM
admet-1037	21	27	in	in	ADP
admet-1037	21	28	2020	2020	NUM
admet-1037	21	29	(	(	PUNCT
admet-1037	21	30	www.pubmed.com	www.pubmed.com	X
admet-1037	21	31	)	)	PUNCT
admet-1037	21	32	.	.	PUNCT
admet-1037	22	1	structurally	structurally	ADV
admet-1037	22	2	,	,	PUNCT
admet-1037	22	3	protacs	protac	NOUN
admet-1037	22	4	®	®	NOUN
admet-1037	22	5	are	be	AUX
admet-1037	22	6	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	PRON
admet-1037	22	7	https://doi.org/10.5599/admet.1037	https://doi.org/10.5599/admet.1037	NOUN
admet-1037	22	8	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1037	22	9	mailto:giuseppe.ermondi@unito.it	mailto:giuseppe.ermondi@unito.it	PROPN
admet-1037	22	10	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1037	22	11	http://www.fda.gov/	http://www.fda.gov/	PROPN
admet-1037	22	12	http://www.pubmed.com/	http://www.pubmed.com/	NOUN
admet-1037	22	13	g.	g.	PROPN
admet-1037	22	14	ermondi	ermondi	PROPN
admet-1037	22	15	et	et	PROPN
admet-1037	22	16	al	al	PROPN
admet-1037	22	17	.	.	PROPN
admet-1037	22	18	admet	admet	PROPN
admet-1037	22	19	&	&	CCONJ
admet-1037	22	20	dmpk	dmpk	PROPN
admet-1037	22	21	9(4	9(4	PROPN
admet-1037	22	22	)	)	PUNCT
admet-1037	22	23	(	(	PUNCT
admet-1037	22	24	2021	2021	NUM
admet-1037	22	25	)	)	PUNCT
admet-1037	22	26	243	243	NUM
admet-1037	22	27	-	-	SYM
admet-1037	22	28	254	254	NUM
admet-1037	22	29	244	244	NUM
admet-1037	22	30	heterobifunctional	heterobifunctional	ADJ
admet-1037	22	31	degraders	degrader	NOUN
admet-1037	22	32	made	make	VERB
admet-1037	22	33	of	of	ADP
admet-1037	22	34	a	a	DET
admet-1037	22	35	warhead	warhead	NOUN
admet-1037	22	36	binding	bind	VERB
admet-1037	22	37	a	a	DET
admet-1037	22	38	protein	protein	NOUN
admet-1037	22	39	of	of	ADP
admet-1037	22	40	interest	interest	NOUN
admet-1037	22	41	(	(	PUNCT
admet-1037	22	42	poi	poi	PROPN
admet-1037	22	43	)	)	PUNCT
admet-1037	22	44	,	,	PUNCT
admet-1037	22	45	a	a	DET
admet-1037	22	46	ligand	ligand	NOUN
admet-1037	22	47	recruiting	recruit	VERB
admet-1037	22	48	an	an	DET
admet-1037	22	49	e3	e3	NOUN
admet-1037	22	50	ligase	ligase	NOUN
admet-1037	22	51	and	and	CCONJ
admet-1037	22	52	a	a	DET
admet-1037	22	53	linker	linker	NOUN
admet-1037	22	54	coupling	couple	VERB
admet-1037	22	55	both	both	DET
admet-1037	22	56	regions	region	NOUN
admet-1037	22	57	(	(	PUNCT
admet-1037	22	58	fig.1	fig.1	PROPN
admet-1037	22	59	)	)	PUNCT
admet-1037	23	1	[	[	X
admet-1037	23	2	2	2	NUM
admet-1037	23	3	]	]	PUNCT
admet-1037	23	4	.	.	PUNCT
admet-1037	24	1	biochemically	biochemically	ADV
admet-1037	24	2	speaking	speak	VERB
admet-1037	24	3	,	,	PUNCT
admet-1037	24	4	their	their	PRON
admet-1037	24	5	mechanism	mechanism	NOUN
admet-1037	24	6	of	of	ADP
admet-1037	24	7	action	action	NOUN
admet-1037	24	8	involves	involve	VERB
admet-1037	24	9	the	the	DET
admet-1037	24	10	formation	formation	NOUN
admet-1037	24	11	of	of	ADP
admet-1037	24	12	a	a	DET
admet-1037	24	13	ternary	ternary	ADJ
admet-1037	24	14	complex	complex	NOUN
admet-1037	24	15	(	(	PUNCT
admet-1037	24	16	e3	e3	NOUN
admet-1037	24	17	ligase	ligase	NOUN
admet-1037	24	18	:	:	PUNCT
admet-1037	24	19	protac	protac	ADJ
admet-1037	24	20	®	®	NOUN
admet-1037	24	21	:poi	:poi	PUNCT
admet-1037	24	22	)	)	PUNCT
admet-1037	24	23	in	in	ADP
admet-1037	24	24	which	which	PRON
admet-1037	24	25	the	the	DET
admet-1037	24	26	e3	e3	NOUN
admet-1037	24	27	ligase	ligase	NOUN
admet-1037	24	28	triggers	trigger	VERB
admet-1037	24	29	the	the	DET
admet-1037	24	30	ubiquitination	ubiquitination	NOUN
admet-1037	24	31	and	and	CCONJ
admet-1037	24	32	subsequent	subsequent	ADJ
admet-1037	24	33	degradation	degradation	NOUN
admet-1037	24	34	of	of	ADP
admet-1037	24	35	the	the	DET
admet-1037	24	36	poi	poi	NOUN
admet-1037	24	37	by	by	ADP
admet-1037	24	38	the	the	DET
admet-1037	24	39	ubiquitin	ubiquitin	ADJ
admet-1037	24	40	-	-	PUNCT
admet-1037	24	41	proteasome	proteasome	NOUN
admet-1037	24	42	system	system	NOUN
admet-1037	24	43	(	(	PUNCT
admet-1037	24	44	ups	up	NOUN
admet-1037	24	45	)	)	PUNCT
admet-1037	25	1	[	[	X
admet-1037	25	2	2	2	NUM
admet-1037	25	3	]	]	PUNCT
admet-1037	25	4	.	.	PUNCT
admet-1037	26	1	figure	figure	NOUN
admet-1037	26	2	1	1	NUM
admet-1037	26	3	.	.	PUNCT
admet-1037	27	1	structure	structure	NOUN
admet-1037	27	2	of	of	ADP
admet-1037	27	3	degraders	degrader	NOUN
admet-1037	27	4	and	and	CCONJ
admet-1037	27	5	their	their	PRON
admet-1037	27	6	building	building	NOUN
admet-1037	27	7	blocks	block	NOUN
admet-1037	27	8	(	(	PUNCT
admet-1037	27	9	arv-825	arv-825	PROPN
admet-1037	27	10	is	be	AUX
admet-1037	27	11	shown	show	VERB
admet-1037	27	12	as	as	ADP
admet-1037	27	13	an	an	DET
admet-1037	27	14	example	example	NOUN
admet-1037	27	15	)	)	PUNCT
admet-1037	27	16	.	.	PUNCT
admet-1037	28	1	unlike	unlike	ADP
admet-1037	28	2	traditional	traditional	ADJ
admet-1037	28	3	small	small	ADJ
admet-1037	28	4	molecules	molecule	NOUN
admet-1037	28	5	,	,	PUNCT
admet-1037	28	6	based	base	VERB
admet-1037	28	7	on	on	ADP
admet-1037	28	8	occupancy	occupancy	NOUN
admet-1037	28	9	pharmacological	pharmacological	ADJ
admet-1037	28	10	effects	effect	NOUN
admet-1037	28	11	,	,	PUNCT
admet-1037	28	12	degraders	degrader	NOUN
admet-1037	28	13	make	make	VERB
admet-1037	28	14	use	use	NOUN
admet-1037	28	15	of	of	ADP
admet-1037	28	16	this	this	DET
admet-1037	28	17	innovative	innovative	ADJ
admet-1037	28	18	event	event	NOUN
admet-1037	28	19	-	-	PUNCT
admet-1037	28	20	driven	drive	VERB
admet-1037	28	21	mechanism	mechanism	NOUN
admet-1037	28	22	of	of	ADP
admet-1037	28	23	action	action	NOUN
admet-1037	28	24	,	,	PUNCT
admet-1037	28	25	presenting	present	VERB
admet-1037	28	26	several	several	ADJ
admet-1037	28	27	advantages	advantage	NOUN
admet-1037	28	28	over	over	ADP
admet-1037	28	29	conventional	conventional	ADJ
admet-1037	28	30	strategies	strategy	NOUN
admet-1037	28	31	.	.	PUNCT
admet-1037	29	1	this	this	PRON
admet-1037	29	2	is	be	AUX
admet-1037	29	3	considered	consider	VERB
admet-1037	29	4	a	a	DET
admet-1037	29	5	catalytic	catalytic	ADJ
admet-1037	29	6	and	and	CCONJ
admet-1037	29	7	sub	sub	ADJ
admet-1037	29	8	-	-	ADJ
admet-1037	29	9	stoichiometric	stoichiometric	ADJ
admet-1037	29	10	event	event	NOUN
admet-1037	29	11	,	,	PUNCT
admet-1037	29	12	which	which	PRON
admet-1037	29	13	allows	allow	VERB
admet-1037	29	14	the	the	DET
admet-1037	29	15	targeting	targeting	NOUN
admet-1037	29	16	of	of	ADP
admet-1037	29	17	several	several	ADJ
admet-1037	29	18	units	unit	NOUN
admet-1037	29	19	of	of	ADP
admet-1037	29	20	the	the	DET
admet-1037	29	21	poi	poi	NOUN
admet-1037	29	22	with	with	ADP
admet-1037	29	23	just	just	ADV
admet-1037	29	24	one	one	NUM
admet-1037	29	25	protac	protac	ADJ
admet-1037	29	26	®	®	NOUN
admet-1037	29	27	molecule	molecule	NOUN
admet-1037	29	28	[	[	X
admet-1037	29	29	3	3	NUM
admet-1037	29	30	]	]	PUNCT
admet-1037	29	31	.	.	PUNCT
admet-1037	30	1	in	in	ADP
admet-1037	30	2	addition	addition	NOUN
admet-1037	30	3	,	,	PUNCT
admet-1037	30	4	due	due	ADP
admet-1037	30	5	to	to	ADP
admet-1037	30	6	its	its	PRON
admet-1037	30	7	event	event	NOUN
admet-1037	30	8	-	-	PUNCT
admet-1037	30	9	driven	drive	VERB
admet-1037	30	10	pharmacology	pharmacology	NOUN
admet-1037	30	11	,	,	PUNCT
admet-1037	30	12	the	the	DET
admet-1037	30	13	degradative	degradative	ADJ
admet-1037	30	14	activity	activity	NOUN
admet-1037	30	15	of	of	ADP
admet-1037	30	16	the	the	DET
admet-1037	30	17	ups	up	NOUN
admet-1037	30	18	does	do	AUX
admet-1037	30	19	not	not	PART
admet-1037	30	20	require	require	VERB
admet-1037	30	21	the	the	DET
admet-1037	30	22	highest	high	ADJ
admet-1037	30	23	affinity	affinity	NOUN
admet-1037	30	24	of	of	ADP
admet-1037	30	25	the	the	DET
admet-1037	30	26	warhead	warhead	NOUN
admet-1037	30	27	for	for	ADP
admet-1037	30	28	the	the	DET
admet-1037	30	29	poi	poi	X
admet-1037	31	1	[	[	X
admet-1037	31	2	4	4	NUM
admet-1037	31	3	]	]	PUNCT
admet-1037	31	4	.	.	PUNCT
admet-1037	32	1	therefore	therefore	ADV
admet-1037	32	2	,	,	PUNCT
admet-1037	32	3	unlike	unlike	ADP
admet-1037	32	4	traditional	traditional	ADJ
admet-1037	32	5	inhibitors	inhibitor	NOUN
admet-1037	32	6	requiring	require	VERB
admet-1037	32	7	higher	high	ADJ
admet-1037	32	8	affinities	affinity	NOUN
admet-1037	32	9	,	,	PUNCT
admet-1037	32	10	degraders	degrader	NOUN
admet-1037	32	11	are	be	AUX
admet-1037	32	12	able	able	ADJ
admet-1037	32	13	to	to	PART
admet-1037	32	14	act	act	VERB
admet-1037	32	15	on	on	ADP
admet-1037	32	16	proteins	protein	NOUN
admet-1037	32	17	thought	think	VERB
admet-1037	32	18	to	to	PART
admet-1037	32	19	be	be	AUX
admet-1037	32	20	´	´	NOUN
admet-1037	32	21	undruggable	undruggable	ADJ
admet-1037	32	22	`	`	PUNCT
admet-1037	32	23	,	,	PUNCT
admet-1037	32	24	which	which	PRON
admet-1037	32	25	expands	expand	VERB
admet-1037	32	26	the	the	DET
admet-1037	32	27	therapeutic	therapeutic	ADJ
admet-1037	32	28	scope	scope	NOUN
admet-1037	32	29	from	from	ADP
admet-1037	32	30	protein	protein	NOUN
admet-1037	32	31	-	-	PUNCT
admet-1037	32	32	dependent	dependent	ADJ
admet-1037	32	33	diseases	disease	NOUN
admet-1037	32	34	to	to	ADP
admet-1037	32	35	viral	viral	ADJ
admet-1037	32	36	infections	infection	NOUN
admet-1037	32	37	,	,	PUNCT
admet-1037	32	38	cancer	cancer	NOUN
admet-1037	32	39	and	and	CCONJ
admet-1037	32	40	immune	immune	ADJ
admet-1037	32	41	and	and	CCONJ
admet-1037	32	42	neurodegenerative	neurodegenerative	ADJ
admet-1037	32	43	disorders	disorder	NOUN
admet-1037	32	44	[	[	X
admet-1037	32	45	5	5	NUM
admet-1037	32	46	]	]	PUNCT
admet-1037	32	47	.	.	PUNCT
admet-1037	33	1	nonetheless	nonetheless	ADV
admet-1037	33	2	,	,	PUNCT
admet-1037	33	3	protac	protac	ADJ
admet-1037	33	4	technology	technology	NOUN
admet-1037	33	5	is	be	AUX
admet-1037	33	6	still	still	ADV
admet-1037	33	7	in	in	ADP
admet-1037	33	8	its	its	PRON
admet-1037	33	9	infancy	infancy	NOUN
admet-1037	33	10	and	and	CCONJ
admet-1037	33	11	is	be	AUX
admet-1037	33	12	not	not	PART
admet-1037	33	13	yet	yet	ADV
admet-1037	33	14	completely	completely	ADV
admet-1037	33	15	understood	understand	VERB
admet-1037	33	16	[	[	PUNCT
admet-1037	33	17	6	6	NUM
admet-1037	33	18	]	]	PUNCT
admet-1037	33	19	.	.	PUNCT
admet-1037	34	1	degraders	degrader	NOUN
admet-1037	34	2	,	,	PUNCT
admet-1037	34	3	first	first	ADV
admet-1037	34	4	introduced	introduce	VERB
admet-1037	34	5	by	by	ADP
admet-1037	34	6	crews	crew	NOUN
admet-1037	34	7	and	and	CCONJ
admet-1037	34	8	deshaies	deshaie	NOUN
admet-1037	34	9	in	in	ADP
admet-1037	34	10	2001	2001	NUM
admet-1037	34	11	[	[	X
admet-1037	34	12	7	7	NUM
admet-1037	34	13	]	]	PUNCT
admet-1037	34	14	,	,	PUNCT
admet-1037	34	15	have	have	VERB
admet-1037	34	16	now	now	ADV
admet-1037	34	17	a	a	DET
admet-1037	34	18	few	few	ADJ
admet-1037	34	19	candidates	candidate	NOUN
admet-1037	34	20	in	in	ADP
admet-1037	34	21	clinical	clinical	ADJ
admet-1037	34	22	trials	trial	NOUN
admet-1037	34	23	.	.	PUNCT
admet-1037	35	1	in	in	ADP
admet-1037	35	2	fact	fact	NOUN
admet-1037	35	3	,	,	PUNCT
admet-1037	35	4	arvinas	arvinas	PROPN
admet-1037	35	5	announced	announce	VERB
admet-1037	35	6	in	in	ADP
admet-1037	35	7	the	the	DET
admet-1037	35	8	first	first	ADJ
admet-1037	35	9	half	half	NOUN
admet-1037	35	10	of	of	ADP
admet-1037	35	11	2020	2020	NUM
admet-1037	35	12	the	the	DET
admet-1037	35	13	first	first	ADJ
admet-1037	35	14	two	two	NUM
admet-1037	35	15	oral	oral	ADJ
admet-1037	35	16	degraders	degrader	NOUN
admet-1037	35	17	to	to	PART
admet-1037	35	18	reach	reach	VERB
admet-1037	35	19	phase	phase	NOUN
admet-1037	35	20	2	2	NUM
admet-1037	35	21	clinical	clinical	ADJ
admet-1037	35	22	trials	trial	NOUN
admet-1037	35	23	(	(	PUNCT
admet-1037	35	24	https://www.arvinas.com	https://www.arvinas.com	NUM
admet-1037	35	25	)	)	PUNCT
admet-1037	35	26	.	.	PUNCT
admet-1037	36	1	moreover	moreover	ADV
admet-1037	36	2	,	,	PUNCT
admet-1037	36	3	the	the	DET
admet-1037	36	4	number	number	NOUN
admet-1037	36	5	of	of	ADP
admet-1037	36	6	protacs	protac	NOUN
admet-1037	36	7	®	®	NOUN
admet-1037	36	8	in	in	ADP
admet-1037	36	9	the	the	DET
admet-1037	36	10	clinic	clinic	NOUN
admet-1037	36	11	should	should	AUX
admet-1037	36	12	rise	rise	VERB
admet-1037	36	13	to	to	ADP
admet-1037	36	14	15	15	NUM
admet-1037	36	15	at	at	ADP
admet-1037	36	16	the	the	DET
admet-1037	36	17	end	end	NOUN
admet-1037	36	18	of	of	ADP
admet-1037	36	19	2021	2021	NUM
admet-1037	36	20	,	,	PUNCT
admet-1037	36	21	which	which	PRON
admet-1037	36	22	reveals	reveal	VERB
admet-1037	36	23	a	a	DET
admet-1037	36	24	higher	high	ADJ
admet-1037	36	25	interest	interest	NOUN
admet-1037	36	26	in	in	ADP
admet-1037	36	27	this	this	DET
admet-1037	36	28	field	field	NOUN
admet-1037	36	29	and	and	CCONJ
admet-1037	36	30	a	a	DET
admet-1037	36	31	better	well	ADJ
admet-1037	36	32	understanding	understanding	NOUN
admet-1037	36	33	of	of	ADP
admet-1037	36	34	their	their	PRON
admet-1037	36	35	functioning	functioning	NOUN
admet-1037	36	36	[	[	X
admet-1037	36	37	8	8	NUM
admet-1037	36	38	]	]	PUNCT
admet-1037	36	39	.	.	PUNCT
admet-1037	37	1	however	however	ADV
admet-1037	37	2	,	,	PUNCT
admet-1037	37	3	despite	despite	SCONJ
admet-1037	37	4	their	their	PRON
admet-1037	37	5	promising	promising	ADJ
admet-1037	37	6	pharmacodynamic	pharmacodynamic	ADJ
admet-1037	37	7	potential	potential	NOUN
admet-1037	37	8	,	,	PUNCT
admet-1037	37	9	the	the	DET
admet-1037	37	10	cautious	cautious	ADJ
admet-1037	37	11	introduction	introduction	NOUN
admet-1037	37	12	of	of	ADP
admet-1037	37	13	protacs	protac	NOUN
admet-1037	37	14	®	®	NOUN
admet-1037	37	15	into	into	ADP
admet-1037	37	16	the	the	DET
admet-1037	37	17	market	market	NOUN
admet-1037	37	18	may	may	AUX
admet-1037	37	19	also	also	ADV
admet-1037	37	20	be	be	AUX
admet-1037	37	21	explained	explain	VERB
admet-1037	37	22	by	by	ADP
admet-1037	37	23	their	their	PRON
admet-1037	37	24	poor	poor	ADJ
admet-1037	37	25	bioavailability	bioavailability	NOUN
admet-1037	37	26	.	.	PUNCT
admet-1037	38	1	moreover	moreover	ADV
admet-1037	38	2	,	,	PUNCT
admet-1037	38	3	this	this	DET
admet-1037	38	4	limitation	limitation	NOUN
admet-1037	38	5	is	be	AUX
admet-1037	38	6	often	often	ADV
admet-1037	38	7	related	relate	VERB
admet-1037	38	8	to	to	ADP
admet-1037	38	9	drug	drug	NOUN
admet-1037	38	10	metabolism	metabolism	NOUN
admet-1037	38	11	and	and	CCONJ
admet-1037	38	12	pharmacokinetics	pharmacokinetic	NOUN
admet-1037	38	13	(	(	PUNCT
admet-1037	38	14	dmpk	dmpk	NOUN
admet-1037	38	15	)	)	PUNCT
admet-1037	38	16	challenges	challenge	NOUN
admet-1037	38	17	,	,	PUNCT
admet-1037	38	18	such	such	ADJ
admet-1037	38	19	as	as	ADP
admet-1037	38	20	water	water	NOUN
admet-1037	38	21	solubility	solubility	NOUN
admet-1037	38	22	and	and	CCONJ
admet-1037	38	23	permeability	permeability	NOUN
admet-1037	38	24	issues	issue	NOUN
admet-1037	38	25	,	,	PUNCT
admet-1037	38	26	derived	derive	VERB
admet-1037	38	27	from	from	ADP
admet-1037	38	28	their	their	PRON
admet-1037	38	29	complex	complex	ADJ
admet-1037	38	30	chemical	chemical	NOUN
admet-1037	38	31	structure	structure	NOUN
admet-1037	38	32	.	.	PUNCT
admet-1037	39	1	chemically	chemically	ADV
admet-1037	39	2	speaking	speak	VERB
admet-1037	39	3	,	,	PUNCT
admet-1037	39	4	degraders	degrader	NOUN
admet-1037	39	5	abandon	abandon	VERB
admet-1037	39	6	the	the	DET
admet-1037	39	7	classical	classical	ADJ
admet-1037	39	8	“	"	PUNCT
admet-1037	39	9	drug	drug	NOUN
admet-1037	39	10	-	-	PUNCT
admet-1037	39	11	like	like	ADJ
admet-1037	39	12	”	"	PUNCT
admet-1037	39	13	context	context	NOUN
admet-1037	39	14	of	of	ADP
admet-1037	39	15	lipinski	lipinski	PROPN
admet-1037	39	16	’s	’s	PART
admet-1037	39	17	rule	rule	NOUN
admet-1037	39	18	-	-	PUNCT
admet-1037	39	19	of	of	ADP
admet-1037	39	20	-	-	PUNCT
admet-1037	39	21	five	five	NUM
admet-1037	39	22	(	(	PUNCT
admet-1037	39	23	ro5	ro5	NOUN
admet-1037	39	24	)	)	PUNCT
admet-1037	39	25	to	to	PART
admet-1037	39	26	be	be	AUX
admet-1037	39	27	considered	consider	VERB
admet-1037	39	28	beyond	beyond	ADP
admet-1037	39	29	the	the	DET
admet-1037	39	30	ro5	ro5	ADJ
admet-1037	39	31	(	(	PUNCT
admet-1037	39	32	bro5	bro5	NOUN
admet-1037	39	33	)	)	PUNCT
admet-1037	39	34	molecules	molecule	NOUN
admet-1037	40	1	[	[	X
admet-1037	40	2	9	9	NUM
admet-1037	40	3	]	]	PUNCT
admet-1037	40	4	.	.	PUNCT
admet-1037	41	1	more	more	ADV
admet-1037	41	2	recently	recently	ADV
admet-1037	41	3	,	,	PUNCT
admet-1037	41	4	newer	new	ADJ
admet-1037	41	5	guidelines	guideline	NOUN
admet-1037	41	6	have	have	AUX
admet-1037	41	7	tried	try	VERB
admet-1037	41	8	to	to	PART
admet-1037	41	9	classify	classify	VERB
admet-1037	41	10	molecules	molecule	NOUN
admet-1037	41	11	attending	attend	VERB
admet-1037	41	12	to	to	ADP
admet-1037	41	13	their	their	PRON
admet-1037	41	14	molecular	molecular	ADJ
admet-1037	41	15	properties	property	NOUN
admet-1037	41	16	.	.	PUNCT
admet-1037	42	1	starting	start	VERB
admet-1037	42	2	from	from	ADP
admet-1037	42	3	lipinski´s	lipinski´s	PROPN
admet-1037	42	4	[	[	X
admet-1037	42	5	9	9	NUM
admet-1037	42	6	]	]	PUNCT
admet-1037	42	7	and	and	CCONJ
admet-1037	42	8	weber´s	weber´s	VERB
admet-1037	42	9	[	[	PUNCT
admet-1037	42	10	10	10	NUM
admet-1037	42	11	]	]	PUNCT
admet-1037	42	12	guidelines	guideline	NOUN
admet-1037	42	13	,	,	PUNCT
admet-1037	42	14	kihlberg	kihlberg	PROPN
admet-1037	42	15	et	et	PROPN
admet-1037	42	16	al	al	PROPN
admet-1037	42	17	.	.	PUNCT
admet-1037	43	1	[	[	X
admet-1037	43	2	11	11	NUM
admet-1037	43	3	]	]	PUNCT
admet-1037	43	4	suggested	suggest	VERB
admet-1037	43	5	several	several	ADJ
admet-1037	43	6	physicochemical	physicochemical	ADJ
admet-1037	43	7	guidelines	guideline	NOUN
admet-1037	43	8	for	for	ADP
admet-1037	43	9	oral	oral	ADJ
admet-1037	43	10	bro5	bro5	NOUN
admet-1037	43	11	drugs	drug	NOUN
admet-1037	43	12	including	include	VERB
admet-1037	43	13	abbvie´s	abbvie´	VERB
admet-1037	43	14	multiparametric	multiparametric	ADJ
admet-1037	43	15	scoring	scoring	NOUN
admet-1037	43	16	function	function	NOUN
admet-1037	43	17	(	(	PUNCT
admet-1037	43	18	ab	ab	NOUN
admet-1037	43	19	-	-	PUNCT
admet-1037	43	20	mps	mp	NOUN
admet-1037	43	21	)	)	PUNCT
admet-1037	44	1	[	[	X
admet-1037	44	2	12	12	NUM
admet-1037	44	3	]	]	PUNCT
admet-1037	44	4	.	.	PUNCT
admet-1037	45	1	moreover	moreover	ADV
admet-1037	45	2	,	,	PUNCT
admet-1037	45	3	these	these	DET
admet-1037	45	4	criteria	criterion	NOUN
admet-1037	45	5	were	be	AUX
admet-1037	45	6	later	later	ADV
admet-1037	45	7	on	on	ADV
admet-1037	45	8	applied	apply	VERB
admet-1037	45	9	to	to	ADP
admet-1037	45	10	protacs	protac	NOUN
admet-1037	45	11	®	®	NOUN
admet-1037	45	12	by	by	ADP
admet-1037	45	13	edmondson	edmondson	PROPN
admet-1037	45	14	et	et	PROPN
admet-1037	45	15	al	al	PROPN
admet-1037	45	16	.	.	PROPN
admet-1037	46	1	in	in	ADP
admet-1037	46	2	2019	2019	NUM
admet-1037	46	3	[	[	SYM
admet-1037	46	4	13	13	NUM
admet-1037	46	5	]	]	PUNCT
admet-1037	46	6	,	,	PUNCT
admet-1037	46	7	who	who	PRON
admet-1037	46	8	evaluated	evaluate	VERB
admet-1037	46	9	several	several	ADJ
admet-1037	46	10	physicochemical	physicochemical	ADJ
admet-1037	46	11	descriptors	descriptor	NOUN
admet-1037	46	12	for	for	ADP
admet-1037	46	13	40	40	NUM
admet-1037	46	14	model	model	NOUN
admet-1037	46	15	protacs	protac	NOUN
admet-1037	46	16	®	®	NOUN
admet-1037	46	17	and	and	CCONJ
admet-1037	46	18	discussed	discuss	VERB
admet-1037	46	19	their	their	PRON
admet-1037	46	20	molecular	molecular	ADJ
admet-1037	46	21	properties	property	NOUN
admet-1037	46	22	based	base	VERB
admet-1037	46	23	on	on	ADP
admet-1037	46	24	their	their	PRON
admet-1037	46	25	e3	e3	NOUN
admet-1037	46	26	ligases	ligase	NOUN
admet-1037	46	27	.	.	PUNCT
admet-1037	47	1	additionally	additionally	ADV
admet-1037	47	2	,	,	PUNCT
admet-1037	47	3	maple	maple	PROPN
admet-1037	47	4	et	et	PROPN
admet-1037	47	5	al	al	PROPN
admet-1037	47	6	.	.	PROPN
admet-1037	48	1	in	in	ADP
admet-1037	48	2	2019	2019	NUM
admet-1037	48	3	[	[	SYM
admet-1037	48	4	14	14	NUM
admet-1037	48	5	]	]	PUNCT
admet-1037	48	6	developed	develop	VERB
admet-1037	48	7	a	a	DET
admet-1037	48	8	study	study	NOUN
admet-1037	48	9	to	to	PART
admet-1037	48	10	examine	examine	VERB
admet-1037	48	11	the	the	DET
admet-1037	48	12	molecular	molecular	ADJ
admet-1037	48	13	properties	property	NOUN
admet-1037	48	14	of	of	ADP
admet-1037	48	15	422	422	NUM
admet-1037	48	16	degraders	degrader	NOUN
admet-1037	48	17	,	,	PUNCT
admet-1037	48	18	establishing	establish	VERB
admet-1037	48	19	a	a	DET
admet-1037	48	20	predictive	predictive	ADJ
admet-1037	48	21	degrader	degrader	NOUN
admet-1037	48	22	score	score	NOUN
admet-1037	48	23	(	(	PUNCT
admet-1037	48	24	deg_s	deg_s	PROPN
admet-1037	48	25	)	)	PUNCT
admet-1037	48	26	.	.	PUNCT
admet-1037	49	1	overall	overall	ADV
admet-1037	49	2	,	,	PUNCT
admet-1037	49	3	these	these	DET
admet-1037	49	4	studies	study	NOUN
admet-1037	49	5	highlight	highlight	VERB
admet-1037	49	6	the	the	DET
admet-1037	49	7	necessity	necessity	NOUN
admet-1037	49	8	for	for	ADP
admet-1037	49	9	property	property	NOUN
admet-1037	49	10	-	-	PUNCT
admet-1037	49	11	based	base	VERB
admet-1037	49	12	resources	resource	NOUN
admet-1037	49	13	that	that	PRON
admet-1037	49	14	enable	enable	VERB
admet-1037	49	15	the	the	DET
admet-1037	49	16	identification	identification	NOUN
admet-1037	49	17	of	of	ADP
admet-1037	49	18	degraders	degrader	NOUN
admet-1037	49	19	with	with	ADP
admet-1037	49	20	a	a	DET
admet-1037	49	21	reasonable	reasonable	ADJ
admet-1037	49	22	potential	potential	NOUN
admet-1037	49	23	to	to	PART
admet-1037	49	24	become	become	VERB
admet-1037	49	25	oral	oral	ADJ
admet-1037	49	26	drugs	drug	NOUN
admet-1037	49	27	[	[	X
admet-1037	49	28	15	15	NUM
admet-1037	49	29	]	]	PUNCT
admet-1037	49	30	.	.	PUNCT
admet-1037	50	1	the	the	DET
admet-1037	50	2	first	first	ADJ
admet-1037	50	3	attempt	attempt	NOUN
admet-1037	50	4	in	in	ADP
admet-1037	50	5	this	this	DET
admet-1037	50	6	direction	direction	NOUN
admet-1037	50	7	was	be	AUX
admet-1037	50	8	recently	recently	ADV
admet-1037	50	9	performed	perform	VERB
admet-1037	50	10	by	by	ADP
admet-1037	50	11	our	our	PRON
admet-1037	50	12	research	research	NOUN
admet-1037	50	13	group	group	NOUN
admet-1037	50	14	using	use	VERB
admet-1037	50	15	a	a	DET
admet-1037	50	16	pool	pool	NOUN
admet-1037	50	17	of	of	ADP
admet-1037	50	18	7	7	NUM
admet-1037	50	19	rationally	rationally	ADV
admet-1037	50	20	selected	select	VERB
admet-1037	50	21	2d	2d	NUM
admet-1037	50	22	molecular	molecular	ADJ
admet-1037	50	23	descriptors	descriptor	NOUN
admet-1037	50	24	(	(	PUNCT
admet-1037	50	25	mw	mw	PROPN
admet-1037	50	26	,	,	PUNCT
admet-1037	50	27	nc	nc	PROPN
admet-1037	50	28	,	,	PUNCT
admet-1037	50	29	nar	nar	NOUN
admet-1037	50	30	,	,	PUNCT
admet-1037	50	31	tpsa	tpsa	NOUN
admet-1037	50	32	,	,	PUNCT
admet-1037	50	33	nhacc	nhacc	NOUN
admet-1037	50	34	,	,	PUNCT
admet-1037	50	35	nhdon	nhdon	NOUN
admet-1037	50	36	and	and	CCONJ
admet-1037	50	37	phi	phi	NOUN
admet-1037	50	38	)	)	PUNCT
admet-1037	50	39	for	for	ADP
admet-1037	50	40	a	a	DET
admet-1037	50	41	dataset	dataset	NOUN
admet-1037	50	42	of	of	ADP
admet-1037	50	43	https://www.arvinas.com/	https://www.arvinas.com/	NOUN
admet-1037	50	44	admet	admet	PROPN
admet-1037	50	45	&	&	CCONJ
admet-1037	50	46	dmpk	dmpk	PROPN
admet-1037	50	47	9(4	9(4	PROPN
admet-1037	50	48	)	)	PUNCT
admet-1037	50	49	(	(	PUNCT
admet-1037	50	50	2021	2021	NUM
admet-1037	50	51	)	)	PUNCT
admet-1037	50	52	243	243	NUM
admet-1037	50	53	-	-	SYM
admet-1037	50	54	254	254	NUM
admet-1037	50	55	are	be	AUX
admet-1037	50	56	we	we	PRON
admet-1037	50	57	ready	ready	ADJ
admet-1037	50	58	to	to	PART
admet-1037	50	59	design	design	VERB
admet-1037	50	60	oral	oral	ADJ
admet-1037	50	61	protacs	protacs	PROPN
admet-1037	50	62	®	®	NOUN
admet-1037	50	63	?	?	PUNCT
admet-1037	51	1	doi	doi	NOUN
admet-1037	51	2	:	:	PUNCT
admet-1037	51	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	NUM
admet-1037	51	4	245	245	NUM
admet-1037	51	5	protacs	protac	NOUN
admet-1037	51	6	®	®	NOUN
admet-1037	51	7	downloaded	download	VERB
admet-1037	51	8	from	from	ADP
admet-1037	51	9	protac	protac	ADJ
admet-1037	51	10	-	-	PUNCT
admet-1037	51	11	db	db	NOUN
admet-1037	51	12	(	(	PUNCT
admet-1037	51	13	http://cadd.zju.edu.cn/protacdb/	http://cadd.zju.edu.cn/protacdb/	NUM
admet-1037	51	14	)	)	PUNCT
admet-1037	52	1	[	[	X
admet-1037	52	2	16	16	NUM
admet-1037	52	3	]	]	X
admet-1037	52	4	,	,	PUNCT
admet-1037	52	5	an	an	DET
admet-1037	52	6	online	online	ADJ
admet-1037	52	7	database	database	NOUN
admet-1037	52	8	exclusively	exclusively	ADV
admet-1037	52	9	devoted	devote	VERB
admet-1037	52	10	to	to	ADP
admet-1037	52	11	degraders	degrader	NOUN
admet-1037	52	12	[	[	X
admet-1037	52	13	17	17	NUM
admet-1037	52	14	]	]	PUNCT
admet-1037	52	15	.	.	PUNCT
admet-1037	53	1	recently	recently	ADV
admet-1037	53	2	protac	protac	ADJ
admet-1037	53	3	-	-	PUNCT
admet-1037	53	4	db	db	PROPN
admet-1037	53	5	has	have	AUX
admet-1037	53	6	been	be	AUX
admet-1037	53	7	significantly	significantly	ADV
admet-1037	53	8	updated	update	VERB
admet-1037	53	9	and	and	CCONJ
admet-1037	53	10	thus	thus	ADV
admet-1037	53	11	the	the	DET
admet-1037	53	12	first	first	ADJ
admet-1037	53	13	aim	aim	NOUN
admet-1037	53	14	of	of	ADP
admet-1037	53	15	the	the	DET
admet-1037	53	16	study	study	NOUN
admet-1037	53	17	is	be	AUX
admet-1037	53	18	to	to	PART
admet-1037	53	19	provide	provide	VERB
admet-1037	53	20	an	an	DET
admet-1037	53	21	overview	overview	NOUN
admet-1037	53	22	of	of	ADP
admet-1037	53	23	this	this	DET
admet-1037	53	24	resource	resource	NOUN
admet-1037	53	25	.	.	PUNCT
admet-1037	54	1	then	then	ADV
admet-1037	54	2	,	,	PUNCT
admet-1037	54	3	after	after	ADP
admet-1037	54	4	recalling	recall	VERB
admet-1037	54	5	the	the	DET
admet-1037	54	6	concept	concept	NOUN
admet-1037	54	7	of	of	ADP
admet-1037	54	8	chemical	chemical	ADJ
admet-1037	54	9	space	space	NOUN
admet-1037	54	10	and	and	CCONJ
admet-1037	54	11	tailoring	tailoring	NOUN
admet-1037	54	12	to	to	PART
admet-1037	54	13	bro5	bro5	NOUN
admet-1037	54	14	molecules	molecule	NOUN
admet-1037	54	15	[	[	X
admet-1037	54	16	18	18	NUM
admet-1037	54	17	]	]	PUNCT
admet-1037	54	18	,	,	PUNCT
admet-1037	54	19	we	we	PRON
admet-1037	54	20	built	build	VERB
admet-1037	54	21	a	a	DET
admet-1037	54	22	protac	protac	ADJ
admet-1037	54	23	®	®	NOUN
admet-1037	54	24	chemical	chemical	NOUN
admet-1037	54	25	space	space	NOUN
admet-1037	54	26	based	base	VERB
admet-1037	54	27	on	on	ADP
admet-1037	54	28	the	the	DET
admet-1037	54	29	aforementioned	aforementioned	ADJ
admet-1037	54	30	descriptors	descriptor	NOUN
admet-1037	54	31	and	and	CCONJ
admet-1037	54	32	investigated	investigate	VERB
admet-1037	54	33	their	their	PRON
admet-1037	54	34	distribution	distribution	NOUN
admet-1037	54	35	in	in	ADP
admet-1037	54	36	relation	relation	NOUN
admet-1037	54	37	to	to	ADP
admet-1037	54	38	a	a	DET
admet-1037	54	39	set	set	NOUN
admet-1037	54	40	of	of	ADP
admet-1037	54	41	oral	oral	ADJ
admet-1037	54	42	available	available	ADJ
admet-1037	54	43	bro5	bro5	NOUN
admet-1037	54	44	drugs	drug	NOUN
admet-1037	54	45	.	.	PUNCT
admet-1037	55	1	finally	finally	ADV
admet-1037	55	2	,	,	PUNCT
admet-1037	55	3	we	we	PRON
admet-1037	55	4	identified	identify	VERB
admet-1037	55	5	in	in	ADP
admet-1037	55	6	this	this	DET
admet-1037	55	7	space	space	NOUN
admet-1037	55	8	the	the	DET
admet-1037	55	9	position	position	NOUN
admet-1037	55	10	of	of	ADP
admet-1037	55	11	a	a	DET
admet-1037	55	12	small	small	ADJ
admet-1037	55	13	set	set	NOUN
admet-1037	55	14	of	of	ADP
admet-1037	55	15	protacs	protac	NOUN
admet-1037	55	16	®	®	NOUN
admet-1037	55	17	for	for	ADP
admet-1037	55	18	which	which	PRON
admet-1037	55	19	either	either	CCONJ
admet-1037	55	20	bioavailability	bioavailability	NOUN
admet-1037	55	21	or	or	CCONJ
admet-1037	55	22	permeability	permeability	NOUN
admet-1037	55	23	has	have	AUX
admet-1037	55	24	been	be	AUX
admet-1037	55	25	experimentally	experimentally	ADV
admet-1037	55	26	determined	determine	VERB
admet-1037	55	27	.	.	PUNCT
admet-1037	56	1	experimental	experimental	ADJ
admet-1037	56	2	protac	protac	ADJ
admet-1037	56	3	®	®	NOUN
admet-1037	56	4	,	,	PUNCT
admet-1037	56	5	warhead	warhead	NOUN
admet-1037	56	6	,	,	PUNCT
admet-1037	56	7	linker	linker	NOUN
admet-1037	56	8	and	and	CCONJ
admet-1037	56	9	e3	e3	PROPN
admet-1037	56	10	ligand	ligand	NOUN
admet-1037	56	11	csv	csv	VERB
admet-1037	56	12	files	file	NOUN
admet-1037	56	13	were	be	AUX
admet-1037	56	14	separately	separately	ADV
admet-1037	56	15	downloaded	download	VERB
admet-1037	56	16	from	from	ADP
admet-1037	56	17	protac	protac	NOUN
admet-1037	56	18	-	-	PUNCT
admet-1037	56	19	db	db	NOUN
admet-1037	56	20	(	(	PUNCT
admet-1037	56	21	last	last	ADJ
admet-1037	56	22	download	download	NOUN
admet-1037	56	23	in	in	ADP
admet-1037	56	24	june	june	PROPN
admet-1037	56	25	2021	2021	NUM
admet-1037	56	26	)	)	PUNCT
admet-1037	56	27	and	and	CCONJ
admet-1037	56	28	converted	convert	VERB
admet-1037	56	29	to	to	ADP
admet-1037	56	30	xlsx	xlsx	NOUN
admet-1037	56	31	files	file	NOUN
admet-1037	56	32	using	use	VERB
admet-1037	56	33	microsoft	microsoft	PROPN
admet-1037	56	34	excel	excel	PROPN
admet-1037	56	35	(	(	PUNCT
admet-1037	56	36	v.	v.	ADV
admet-1037	56	37	16.0	16.0	NUM
admet-1037	56	38	)	)	PUNCT
admet-1037	56	39	.	.	PUNCT
admet-1037	57	1	data	datum	NOUN
admet-1037	57	2	entries	entry	NOUN
admet-1037	57	3	were	be	AUX
admet-1037	57	4	submitted	submit	VERB
admet-1037	57	5	to	to	ADP
admet-1037	57	6	osiris	osiris	VERB
admet-1037	57	7	datawarrior	datawarrior	ADJ
admet-1037	57	8	version	version	NOUN
admet-1037	57	9	5.2.1	5.2.1	NUM
admet-1037	57	10	(	(	PUNCT
admet-1037	57	11	http://www.openmolecules.org/datawarrior/	http://www.openmolecules.org/datawarrior/	X
admet-1037	57	12	)	)	PUNCT
admet-1037	57	13	and	and	CCONJ
admet-1037	57	14	alvadesc	alvadesc	ADV
admet-1037	57	15	2.0.0	2.0.0	NUM
admet-1037	57	16	(	(	PUNCT
admet-1037	57	17	https://www.alvascience.com/alvadesc/	https://www.alvascience.com/alvadesc/	X
admet-1037	57	18	)	)	PUNCT
admet-1037	57	19	.	.	PUNCT
admet-1037	58	1	mw	mw	PROPN
admet-1037	58	2	,	,	PUNCT
admet-1037	58	3	nc	nc	PROPN
admet-1037	58	4	,	,	PUNCT
admet-1037	58	5	phi	phi	NOUN
admet-1037	58	6	,	,	PUNCT
admet-1037	58	7	nhdon	nhdon	PROPN
admet-1037	58	8	,	,	PUNCT
admet-1037	58	9	nhacc	nhacc	NOUN
admet-1037	58	10	and	and	CCONJ
admet-1037	58	11	tpsa(tot	tpsa(tot	PROPN
admet-1037	58	12	)	)	PUNCT
admet-1037	58	13	were	be	AUX
admet-1037	58	14	calculated	calculate	VERB
admet-1037	58	15	with	with	ADP
admet-1037	58	16	alvadesc	alvadesc	NOUN
admet-1037	58	17	and	and	CCONJ
admet-1037	58	18	nar	nar	NOUN
admet-1037	58	19	with	with	ADP
admet-1037	58	20	datawarrior	datawarrior	NOUN
admet-1037	58	21	.	.	PUNCT
admet-1037	59	1	calculated	calculate	VERB
admet-1037	59	2	values	value	NOUN
admet-1037	59	3	were	be	AUX
admet-1037	59	4	then	then	ADV
admet-1037	59	5	exported	export	VERB
admet-1037	59	6	to	to	PART
admet-1037	59	7	excel	excel	VERB
admet-1037	59	8	and	and	CCONJ
admet-1037	59	9	plotted	plot	VERB
admet-1037	59	10	into	into	ADP
admet-1037	59	11	3d	3d	NUM
admet-1037	59	12	graphs	graph	NOUN
admet-1037	59	13	with	with	ADP
admet-1037	59	14	datawarrior	datawarrior	NOUN
admet-1037	59	15	.	.	PUNCT
admet-1037	60	1	results	result	NOUN
admet-1037	60	2	and	and	CCONJ
admet-1037	60	3	discussion	discussion	NOUN
admet-1037	60	4	protacs	protac	NOUN
admet-1037	60	5	®	®	NOUN
admet-1037	60	6	available	available	ADJ
admet-1037	60	7	structures	structure	NOUN
admet-1037	60	8	:	:	PUNCT
admet-1037	60	9	protac	protac	ADJ
admet-1037	60	10	-	-	PUNCT
admet-1037	60	11	db	db	NOUN
admet-1037	60	12	analysis	analysis	NOUN
admet-1037	60	13	common	common	ADJ
admet-1037	60	14	databases	database	NOUN
admet-1037	60	15	,	,	PUNCT
admet-1037	60	16	chembl	chembl	NOUN
admet-1037	60	17	for	for	ADP
admet-1037	60	18	instance	instance	NOUN
admet-1037	60	19	,	,	PUNCT
admet-1037	60	20	are	be	AUX
admet-1037	60	21	expected	expect	VERB
admet-1037	60	22	to	to	PART
admet-1037	60	23	enhance	enhance	VERB
admet-1037	60	24	drug	drug	NOUN
admet-1037	60	25	discovery	discovery	NOUN
admet-1037	60	26	performance	performance	NOUN
admet-1037	60	27	.	.	PUNCT
admet-1037	61	1	however	however	ADV
admet-1037	61	2	,	,	PUNCT
admet-1037	61	3	the	the	DET
admet-1037	61	4	complexity	complexity	NOUN
admet-1037	61	5	of	of	ADP
admet-1037	61	6	protacs	protac	NOUN
admet-1037	61	7	®	®	NOUN
admet-1037	61	8	(	(	PUNCT
admet-1037	61	9	and	and	CCONJ
admet-1037	61	10	of	of	ADP
admet-1037	61	11	most	most	ADJ
admet-1037	61	12	bro5	bro5	NOUN
admet-1037	61	13	compounds	compound	NOUN
admet-1037	61	14	)	)	PUNCT
admet-1037	61	15	may	may	AUX
admet-1037	61	16	require	require	VERB
admet-1037	61	17	bespoke	bespoke	ADJ
admet-1037	61	18	approaches	approach	NOUN
admet-1037	61	19	[	[	X
admet-1037	61	20	17	17	NUM
admet-1037	61	21	]	]	PUNCT
admet-1037	61	22	.	.	PUNCT
admet-1037	62	1	for	for	ADP
admet-1037	62	2	instance	instance	NOUN
admet-1037	62	3	,	,	PUNCT
admet-1037	62	4	the	the	DET
admet-1037	62	5	chemical	chemical	NOUN
admet-1037	62	6	probes	probe	NOUN
admet-1037	62	7	portal	portal	NOUN
admet-1037	62	8	is	be	AUX
admet-1037	62	9	starting	start	VERB
admet-1037	62	10	to	to	PART
admet-1037	62	11	include	include	VERB
admet-1037	62	12	a	a	DET
admet-1037	62	13	preliminary	preliminary	ADJ
admet-1037	62	14	dataset	dataset	NOUN
admet-1037	62	15	of	of	ADP
admet-1037	62	16	degraders	degrader	NOUN
admet-1037	62	17	along	along	ADP
admet-1037	62	18	with	with	ADP
admet-1037	62	19	their	their	PRON
admet-1037	62	20	targets	target	NOUN
admet-1037	62	21	to	to	PART
admet-1037	62	22	help	help	VERB
admet-1037	62	23	protac	protac	ADJ
admet-1037	62	24	®	®	NOUN
admet-1037	62	25	drug	drug	NOUN
admet-1037	62	26	discovery	discovery	NOUN
admet-1037	62	27	,	,	PUNCT
admet-1037	62	28	but	but	CCONJ
admet-1037	62	29	it	it	PRON
admet-1037	62	30	is	be	AUX
admet-1037	62	31	still	still	ADV
admet-1037	62	32	very	very	ADV
admet-1037	62	33	limited	limited	ADJ
admet-1037	62	34	(	(	PUNCT
admet-1037	62	35	www.chemicalprobes.org	www.chemicalprobes.org	NOUN
admet-1037	62	36	)	)	PUNCT
admet-1037	62	37	.	.	PUNCT
admet-1037	63	1	probes	probe	NOUN
admet-1037	63	2	&	&	CCONJ
admet-1037	63	3	drugs	drug	NOUN
admet-1037	63	4	(	(	PUNCT
admet-1037	63	5	www.probes-drugs.org/home/	www.probes-drugs.org/home/	PROPN
admet-1037	63	6	)	)	PUNCT
admet-1037	63	7	have	have	AUX
admet-1037	63	8	recently	recently	ADV
admet-1037	63	9	updated	update	VERB
admet-1037	63	10	their	their	PRON
admet-1037	63	11	content	content	NOUN
admet-1037	63	12	in	in	ADP
admet-1037	63	13	protacs	protac	NOUN
admet-1037	63	14	®	®	NOUN
admet-1037	63	15	with	with	ADP
admet-1037	63	16	data	datum	NOUN
admet-1037	63	17	obtained	obtain	VERB
admet-1037	63	18	directly	directly	ADV
admet-1037	63	19	from	from	ADP
admet-1037	63	20	the	the	DET
admet-1037	63	21	protac	protac	NOUN
admet-1037	63	22	-	-	PUNCT
admet-1037	63	23	db	db	NOUN
admet-1037	63	24	which	which	PRON
admet-1037	63	25	is	be	AUX
admet-1037	63	26	an	an	DET
admet-1037	63	27	online	online	ADJ
admet-1037	63	28	database	database	NOUN
admet-1037	63	29	fully	fully	ADV
admet-1037	63	30	focused	focus	VERB
admet-1037	63	31	on	on	ADP
admet-1037	63	32	protacs	protac	NOUN
admet-1037	63	33	®	®	NOUN
admet-1037	63	34	(	(	PUNCT
admet-1037	63	35	http://cadd.zju.edu.cn/protacdb/	http://cadd.zju.edu.cn/protacdb/	NUM
admet-1037	63	36	)	)	PUNCT
admet-1037	63	37	.	.	PUNCT
admet-1037	64	1	this	this	DET
admet-1037	64	2	latter	latter	ADJ
admet-1037	64	3	introduces	introduce	NOUN
admet-1037	64	4	for	for	ADP
admet-1037	64	5	the	the	DET
admet-1037	64	6	first	first	ADJ
admet-1037	64	7	time	time	NOUN
admet-1037	64	8	a	a	DET
admet-1037	64	9	search	search	NOUN
admet-1037	64	10	engine	engine	NOUN
admet-1037	64	11	based	base	VERB
admet-1037	64	12	on	on	ADP
admet-1037	64	13	any	any	PRON
admet-1037	64	14	of	of	ADP
admet-1037	64	15	the	the	DET
admet-1037	64	16	three	three	NUM
admet-1037	64	17	components	component	NOUN
admet-1037	64	18	of	of	ADP
admet-1037	64	19	the	the	DET
admet-1037	64	20	degrader	degrader	NOUN
admet-1037	64	21	.	.	PUNCT
admet-1037	65	1	consequently	consequently	ADV
admet-1037	65	2	,	,	PUNCT
admet-1037	65	3	the	the	DET
admet-1037	65	4	search	search	NOUN
admet-1037	65	5	for	for	ADP
admet-1037	65	6	protacs	protac	NOUN
admet-1037	65	7	®	®	NOUN
admet-1037	65	8	becomes	become	VERB
admet-1037	65	9	more	more	ADJ
admet-1037	65	10	user	user	NOUN
admet-1037	65	11	-	-	PUNCT
admet-1037	65	12	friendly	friendly	ADJ
admet-1037	65	13	,	,	PUNCT
admet-1037	65	14	in	in	ADP
admet-1037	65	15	which	which	PRON
admet-1037	65	16	every	every	DET
admet-1037	65	17	protac	protac	ADJ
admet-1037	65	18	entry	entry	NOUN
admet-1037	65	19	is	be	AUX
admet-1037	65	20	now	now	ADV
admet-1037	65	21	considered	consider	VERB
admet-1037	65	22	as	as	ADP
admet-1037	65	23	an	an	DET
admet-1037	65	24	addition	addition	NOUN
admet-1037	65	25	of	of	ADP
admet-1037	65	26	chemical	chemical	ADJ
admet-1037	65	27	moieties	moiety	NOUN
admet-1037	65	28	rather	rather	ADV
admet-1037	65	29	than	than	ADP
admet-1037	65	30	just	just	ADV
admet-1037	65	31	a	a	DET
admet-1037	65	32	fixed	fixed	ADJ
admet-1037	65	33	chemical	chemical	NOUN
admet-1037	65	34	structure	structure	NOUN
admet-1037	65	35	with	with	ADP
admet-1037	65	36	a	a	DET
admet-1037	65	37	database	database	NOUN
admet-1037	65	38	i	i	X
admet-1037	65	39	d.	d.	PROPN
admet-1037	65	40	the	the	DET
admet-1037	65	41	protac	protac	NOUN
admet-1037	65	42	-	-	PUNCT
admet-1037	65	43	db	db	NOUN
admet-1037	65	44	provides	provide	VERB
admet-1037	65	45	first	first	ADJ
admet-1037	65	46	-	-	PUNCT
admet-1037	65	47	hand	hand	NOUN
admet-1037	65	48	information	information	NOUN
admet-1037	65	49	about	about	ADP
admet-1037	65	50	chemical	chemical	NOUN
admet-1037	65	51	structures	structure	NOUN
admet-1037	65	52	,	,	PUNCT
admet-1037	65	53	biological	biological	ADJ
admet-1037	65	54	activities	activity	NOUN
admet-1037	65	55	,	,	PUNCT
admet-1037	65	56	and	and	CCONJ
admet-1037	65	57	physicochemical	physicochemical	ADJ
admet-1037	65	58	properties	property	NOUN
admet-1037	65	59	,	,	PUNCT
admet-1037	65	60	retrieved	retrieve	VERB
admet-1037	65	61	from	from	ADP
admet-1037	65	62	pubchem	pubchem	NOUN
admet-1037	65	63	,	,	PUNCT
admet-1037	65	64	chembl	chembl	NOUN
admet-1037	65	65	[	[	X
admet-1037	65	66	19	19	NUM
admet-1037	65	67	]	]	PUNCT
admet-1037	65	68	,	,	PUNCT
admet-1037	65	69	bindingdb	bindingdb	VERB
admet-1037	66	1	[	[	X
admet-1037	66	2	20	20	NUM
admet-1037	66	3	]	]	PUNCT
admet-1037	66	4	,	,	PUNCT
admet-1037	66	5	and	and	CCONJ
admet-1037	66	6	literature	literature	NOUN
admet-1037	66	7	.	.	PUNCT
admet-1037	67	1	in	in	ADP
admet-1037	67	2	particular	particular	ADJ
admet-1037	67	3	,	,	PUNCT
admet-1037	67	4	physicochemical	physicochemical	ADJ
admet-1037	67	5	properties	property	NOUN
admet-1037	67	6	are	be	AUX
admet-1037	67	7	calculated	calculate	VERB
admet-1037	67	8	by	by	ADP
admet-1037	67	9	rdkit	rdkit	NOUN
admet-1037	67	10	(	(	PUNCT
admet-1037	67	11	www.rdkit.org	www.rdkit.org	PROPN
admet-1037	67	12	)	)	PUNCT
admet-1037	67	13	and	and	CCONJ
admet-1037	67	14	alogps	alogps	PROPN
admet-1037	67	15	software	software	NOUN
admet-1037	67	16	[	[	X
admet-1037	67	17	21	21	NUM
admet-1037	67	18	]	]	PUNCT
admet-1037	67	19	.	.	PUNCT
admet-1037	68	1	up	up	ADP
admet-1037	68	2	to	to	ADP
admet-1037	68	3	date	date	NOUN
admet-1037	68	4	,	,	PUNCT
admet-1037	68	5	2258	2258	NUM
admet-1037	68	6	published	publish	VERB
admet-1037	68	7	protacs	protacs	PROPN
admet-1037	68	8	®	®	NOUN
admet-1037	68	9	,	,	PUNCT
admet-1037	68	10	275	275	NUM
admet-1037	68	11	warheads	warhead	NOUN
admet-1037	68	12	,	,	PUNCT
admet-1037	68	13	68	68	NUM
admet-1037	68	14	e3	e3	NOUN
admet-1037	68	15	ligands	ligand	NOUN
admet-1037	68	16	and	and	CCONJ
admet-1037	68	17	1099	1099	NUM
admet-1037	68	18	linkers	linker	NOUN
admet-1037	68	19	are	be	AUX
admet-1037	68	20	contained	contain	VERB
admet-1037	68	21	in	in	ADP
admet-1037	68	22	the	the	DET
admet-1037	68	23	protac	protac	NOUN
admet-1037	68	24	-	-	PUNCT
admet-1037	68	25	db	db	NOUN
admet-1037	68	26	(	(	PUNCT
admet-1037	68	27	last	last	ADJ
admet-1037	68	28	download	download	NOUN
admet-1037	68	29	june	june	PROPN
admet-1037	68	30	2021	2021	NUM
admet-1037	68	31	)	)	PUNCT
admet-1037	68	32	.	.	PUNCT
admet-1037	69	1	due	due	ADP
admet-1037	69	2	to	to	ADP
admet-1037	69	3	the	the	DET
admet-1037	69	4	extensive	extensive	ADJ
admet-1037	69	5	information	information	NOUN
admet-1037	69	6	provided	provide	VERB
admet-1037	69	7	,	,	PUNCT
admet-1037	69	8	regarding	regard	VERB
admet-1037	69	9	public	public	ADJ
admet-1037	69	10	and	and	CCONJ
admet-1037	69	11	available	available	ADJ
admet-1037	69	12	information	information	NOUN
admet-1037	69	13	,	,	PUNCT
admet-1037	69	14	the	the	DET
admet-1037	69	15	protac	protac	NOUN
admet-1037	69	16	-	-	PUNCT
admet-1037	69	17	db	db	NOUN
admet-1037	69	18	is	be	AUX
admet-1037	69	19	the	the	DET
admet-1037	69	20	best	good	ADJ
admet-1037	69	21	online	online	ADJ
admet-1037	69	22	source	source	NOUN
admet-1037	69	23	to	to	PART
admet-1037	69	24	perform	perform	VERB
admet-1037	69	25	a	a	DET
admet-1037	69	26	preliminary	preliminary	ADJ
admet-1037	69	27	analysis	analysis	NOUN
admet-1037	69	28	of	of	ADP
admet-1037	69	29	the	the	DET
admet-1037	69	30	state	state	NOUN
admet-1037	69	31	of	of	ADP
admet-1037	69	32	the	the	DET
admet-1037	69	33	art	art	NOUN
admet-1037	69	34	in	in	ADP
admet-1037	69	35	protac	protac	ADJ
admet-1037	69	36	®	®	NOUN
admet-1037	69	37	technology	technology	NOUN
admet-1037	69	38	.	.	PUNCT
admet-1037	70	1	thus	thus	ADV
admet-1037	70	2	,	,	PUNCT
admet-1037	70	3	all	all	DET
admet-1037	70	4	the	the	DET
admet-1037	70	5	entries	entry	NOUN
admet-1037	70	6	including	include	VERB
admet-1037	70	7	protacs	protac	NOUN
admet-1037	70	8	®	®	NOUN
admet-1037	70	9	,	,	PUNCT
admet-1037	70	10	warheads	warhead	NOUN
admet-1037	70	11	and	and	CCONJ
admet-1037	70	12	e3	e3	NOUN
admet-1037	70	13	ligands	ligand	NOUN
admet-1037	70	14	were	be	AUX
admet-1037	70	15	downloaded	download	VERB
admet-1037	70	16	from	from	ADP
admet-1037	70	17	the	the	DET
admet-1037	70	18	protac	protac	NOUN
admet-1037	70	19	-	-	PUNCT
admet-1037	70	20	db	db	NOUN
admet-1037	70	21	.	.	PUNCT
admet-1037	71	1	it	it	PRON
admet-1037	71	2	is	be	AUX
admet-1037	71	3	necessary	necessary	ADJ
admet-1037	71	4	to	to	PART
admet-1037	71	5	highlight	highlight	VERB
admet-1037	71	6	that	that	SCONJ
admet-1037	71	7	the	the	DET
admet-1037	71	8	number	number	NOUN
admet-1037	71	9	of	of	ADP
admet-1037	71	10	available	available	ADJ
admet-1037	71	11	entries	entry	NOUN
admet-1037	71	12	for	for	ADP
admet-1037	71	13	each	each	DET
admet-1037	71	14	structural	structural	ADJ
admet-1037	71	15	group	group	NOUN
admet-1037	71	16	is	be	AUX
admet-1037	71	17	slightly	slightly	ADV
admet-1037	71	18	higher	high	ADJ
admet-1037	71	19	than	than	ADP
admet-1037	71	20	the	the	DET
admet-1037	71	21	number	number	NOUN
admet-1037	71	22	of	of	ADP
admet-1037	71	23	reported	report	VERB
admet-1037	71	24	molecular	molecular	ADJ
admet-1037	71	25	ids	id	NOUN
admet-1037	71	26	.	.	PUNCT
admet-1037	72	1	therefore	therefore	ADV
admet-1037	72	2	,	,	PUNCT
admet-1037	72	3	3939	3939	NUM
admet-1037	72	4	protac	protac	ADJ
admet-1037	72	5	®	®	NOUN
admet-1037	72	6	entries	entry	NOUN
admet-1037	72	7	were	be	AUX
admet-1037	72	8	reported	report	VERB
admet-1037	72	9	for	for	ADP
admet-1037	72	10	2258	2258	NUM
admet-1037	72	11	protacs	protac	NOUN
admet-1037	72	12	®	®	NOUN
admet-1037	72	13	,	,	PUNCT
admet-1037	72	14	74	74	NUM
admet-1037	72	15	e3	e3	NOUN
admet-1037	72	16	ligand	ligand	NOUN
admet-1037	72	17	entries	entry	NOUN
admet-1037	72	18	for	for	ADP
admet-1037	72	19	68	68	NUM
admet-1037	72	20	e3	e3	NOUN
admet-1037	72	21	ligand	ligand	NOUN
admet-1037	72	22	structures	structure	NOUN
admet-1037	72	23	and	and	CCONJ
admet-1037	72	24	973	973	NUM
admet-1037	72	25	warhead	warhead	NOUN
admet-1037	72	26	entries	entry	NOUN
admet-1037	72	27	for	for	ADP
admet-1037	72	28	275	275	NUM
admet-1037	72	29	warheads	warhead	NOUN
admet-1037	72	30	.	.	PUNCT
admet-1037	73	1	this	this	DET
admet-1037	73	2	fact	fact	NOUN
admet-1037	73	3	points	point	VERB
admet-1037	73	4	out	out	ADP
admet-1037	73	5	the	the	DET
admet-1037	73	6	versatility	versatility	NOUN
admet-1037	73	7	of	of	ADP
admet-1037	73	8	some	some	DET
admet-1037	73	9	structures	structure	NOUN
admet-1037	73	10	within	within	ADP
admet-1037	73	11	every	every	DET
admet-1037	73	12	group	group	NOUN
admet-1037	73	13	,	,	PUNCT
admet-1037	73	14	which	which	PRON
admet-1037	73	15	can	can	AUX
admet-1037	73	16	indeed	indeed	ADV
admet-1037	73	17	target	target	VERB
admet-1037	73	18	more	more	ADJ
admet-1037	73	19	than	than	ADP
admet-1037	73	20	one	one	NUM
admet-1037	73	21	protein	protein	NOUN
admet-1037	73	22	(	(	PUNCT
admet-1037	73	23	i.e.	i.e.	X
admet-1037	73	24	,	,	PUNCT
admet-1037	73	25	protac	protac	ADJ
admet-1037	73	26	®	®	NOUN
admet-1037	73	27	i	i	PROPN
admet-1037	73	28	d	d	PROPN
admet-1037	73	29	2199	2199	NUM
admet-1037	73	30	can	can	AUX
admet-1037	73	31	be	be	AUX
admet-1037	73	32	used	use	VERB
admet-1037	73	33	to	to	PART
admet-1037	73	34	target	target	VERB
admet-1037	73	35	clk1	clk1	NOUN
admet-1037	73	36	or	or	CCONJ
admet-1037	73	37	cdk9	cdk9	NOUN
admet-1037	73	38	proteins	protein	NOUN
admet-1037	73	39	)	)	PUNCT
admet-1037	73	40	.	.	PUNCT
admet-1037	74	1	hence	hence	ADV
admet-1037	74	2	,	,	PUNCT
admet-1037	74	3	to	to	PART
admet-1037	74	4	have	have	VERB
admet-1037	74	5	a	a	DET
admet-1037	74	6	clear	clear	ADJ
admet-1037	74	7	picture	picture	NOUN
admet-1037	74	8	of	of	ADP
admet-1037	74	9	the	the	DET
admet-1037	74	10	current	current	ADJ
admet-1037	74	11	trend	trend	NOUN
admet-1037	74	12	,	,	PUNCT
admet-1037	74	13	protac	protac	ADJ
admet-1037	74	14	-	-	PUNCT
admet-1037	74	15	db	db	NOUN
admet-1037	74	16	entries	entry	NOUN
admet-1037	74	17	were	be	AUX
admet-1037	74	18	classified	classify	VERB
admet-1037	74	19	through	through	ADP
admet-1037	74	20	their	their	PRON
admet-1037	74	21	targeted	target	VERB
admet-1037	74	22	protein	protein	NOUN
admet-1037	74	23	and	and	CCONJ
admet-1037	74	24	their	their	PRON
admet-1037	74	25	corresponding	corresponding	ADJ
admet-1037	74	26	protein	protein	NOUN
admet-1037	74	27	families	family	NOUN
admet-1037	74	28	.	.	PUNCT
admet-1037	75	1	moreover	moreover	ADV
admet-1037	75	2	,	,	PUNCT
admet-1037	75	3	a	a	DET
admet-1037	75	4	count	count	NOUN
admet-1037	75	5	was	be	AUX
admet-1037	75	6	performed	perform	VERB
admet-1037	75	7	,	,	PUNCT
admet-1037	75	8	and	and	CCONJ
admet-1037	75	9	the	the	DET
admet-1037	75	10	corresponding	corresponding	ADJ
admet-1037	75	11	protein	protein	NOUN
admet-1037	75	12	/	/	SYM
admet-1037	75	13	family	family	NOUN
admet-1037	75	14	clusters	cluster	NOUN
admet-1037	75	15	were	be	AUX
admet-1037	75	16	sorted	sort	VERB
admet-1037	75	17	by	by	ADP
admet-1037	75	18	size	size	NOUN
admet-1037	75	19	.	.	PUNCT
admet-1037	76	1	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	PRON
admet-1037	76	2	http://cadd.zju.edu.cn/protacdb/	http://cadd.zju.edu.cn/protacdb/	X
admet-1037	76	3	http://www.openmolecules.org/datawarrior/	http://www.openmolecules.org/datawarrior/	PRON
admet-1037	76	4	https://www.alvascience.com/alvadesc/	https://www.alvascience.com/alvadesc/	X
admet-1037	76	5	http://www.probes-drugs.org/home/	http://www.probes-drugs.org/home/	PROPN
admet-1037	76	6	http://cadd.zju.edu.cn/protacdb/	http://cadd.zju.edu.cn/protacdb/	NUM
admet-1037	77	1	http://www.rdkit.org/	http://www.rdkit.org/	NOUN
admet-1037	77	2	g.	g.	PROPN
admet-1037	77	3	ermondi	ermondi	PROPN
admet-1037	77	4	et	et	PROPN
admet-1037	77	5	al	al	PROPN
admet-1037	77	6	.	.	PROPN
admet-1037	77	7	admet	admet	PROPN
admet-1037	77	8	&	&	CCONJ
admet-1037	77	9	dmpk	dmpk	PROPN
admet-1037	77	10	9(4	9(4	PROPN
admet-1037	77	11	)	)	PUNCT
admet-1037	77	12	(	(	PUNCT
admet-1037	77	13	2021	2021	NUM
admet-1037	77	14	)	)	PUNCT
admet-1037	77	15	243	243	NUM
admet-1037	77	16	-	-	SYM
admet-1037	77	17	254	254	NUM
admet-1037	77	18	246	246	NUM
admet-1037	77	19	the	the	DET
admet-1037	77	20	main	main	ADJ
admet-1037	77	21	e3	e3	NOUN
admet-1037	77	22	ligase	ligase	NOUN
admet-1037	77	23	clusters	cluster	NOUN
admet-1037	77	24	are	be	AUX
admet-1037	77	25	represented	represent	VERB
admet-1037	77	26	in	in	ADP
admet-1037	77	27	frequency	frequency	NOUN
admet-1037	77	28	histograms	histogram	NOUN
admet-1037	77	29	(	(	PUNCT
admet-1037	77	30	fig	fig	NOUN
admet-1037	77	31	.	.	PUNCT
admet-1037	78	1	2	2	NUM
admet-1037	78	2	)	)	PUNCT
admet-1037	78	3	.	.	PUNCT
admet-1037	79	1	from	from	ADP
admet-1037	79	2	the	the	DET
admet-1037	79	3	74	74	NUM
admet-1037	79	4	e3	e3	NOUN
admet-1037	79	5	ligand	ligand	NOUN
admet-1037	79	6	entries	entry	NOUN
admet-1037	79	7	,	,	PUNCT
admet-1037	79	8	27	27	NUM
admet-1037	79	9	targeted	target	VERB
admet-1037	79	10	vhl	vhl	NOUN
admet-1037	79	11	,	,	PUNCT
admet-1037	79	12	23	23	NUM
admet-1037	79	13	iaps	iap	NOUN
admet-1037	79	14	and	and	CCONJ
admet-1037	79	15	10	10	NUM
admet-1037	79	16	crbn	crbn	NOUN
admet-1037	79	17	,	,	PUNCT
admet-1037	79	18	revealing	reveal	VERB
admet-1037	79	19	that	that	SCONJ
admet-1037	79	20	e3	e3	NOUN
admet-1037	79	21	ligands	ligand	NOUN
admet-1037	79	22	focus	focus	VERB
admet-1037	79	23	mainly	mainly	ADV
admet-1037	79	24	on	on	ADP
admet-1037	79	25	these	these	DET
admet-1037	79	26	3	3	NUM
admet-1037	79	27	families	family	NOUN
admet-1037	79	28	of	of	ADP
admet-1037	79	29	targets	target	NOUN
admet-1037	79	30	(	(	PUNCT
admet-1037	79	31	36	36	NUM
admet-1037	79	32	,	,	PUNCT
admet-1037	79	33	31	31	NUM
admet-1037	79	34	and	and	CCONJ
admet-1037	79	35	14	14	NUM
admet-1037	79	36	%	%	NOUN
admet-1037	79	37	,	,	PUNCT
admet-1037	79	38	respectively	respectively	ADV
admet-1037	79	39	)	)	PUNCT
admet-1037	79	40	(	(	PUNCT
admet-1037	79	41	fig	fig	NOUN
admet-1037	79	42	.	.	PUNCT
admet-1037	79	43	2a	2a	NUM
admet-1037	79	44	)	)	PUNCT
admet-1037	79	45	.	.	PUNCT
admet-1037	80	1	when	when	SCONJ
admet-1037	80	2	considering	consider	VERB
admet-1037	80	3	specific	specific	ADJ
admet-1037	80	4	e3	e3	NOUN
admet-1037	80	5	ligase	ligase	NOUN
admet-1037	80	6	proteins	protein	NOUN
admet-1037	80	7	(	(	PUNCT
admet-1037	80	8	fig	fig	NOUN
admet-1037	80	9	.	.	PUNCT
admet-1037	80	10	2b	2b	NUM
admet-1037	80	11	)	)	PUNCT
admet-1037	80	12	,	,	PUNCT
admet-1037	80	13	vhl	vhl	PROPN
admet-1037	80	14	remains	remain	VERB
admet-1037	80	15	the	the	DET
admet-1037	80	16	most	most	ADV
admet-1037	80	17	widely	widely	ADV
admet-1037	80	18	used	use	VERB
admet-1037	80	19	e3	e3	NOUN
admet-1037	80	20	ligase	ligase	NOUN
admet-1037	80	21	(	(	PUNCT
admet-1037	80	22	36	36	NUM
admet-1037	80	23	%	%	NOUN
admet-1037	80	24	)	)	PUNCT
admet-1037	80	25	.	.	PUNCT
admet-1037	81	1	moreover	moreover	ADV
admet-1037	81	2	,	,	PUNCT
admet-1037	81	3	the	the	DET
admet-1037	81	4	iap	iap	PROPN
admet-1037	81	5	family	family	PROPN
admet-1037	81	6	is	be	AUX
admet-1037	81	7	subdivided	subdivide	VERB
admet-1037	81	8	into	into	ADP
admet-1037	81	9	xiap	xiap	PROPN
admet-1037	81	10	(	(	PUNCT
admet-1037	81	11	14	14	NUM
admet-1037	81	12	%	%	NOUN
admet-1037	81	13	)	)	PUNCT
admet-1037	81	14	,	,	PUNCT
admet-1037	81	15	ciap1	ciap1	PROPN
admet-1037	81	16	/	/	SYM
admet-1037	81	17	birc2	birc2	PROPN
admet-1037	81	18	(	(	PUNCT
admet-1037	81	19	9	9	NUM
admet-1037	81	20	%	%	NOUN
admet-1037	81	21	)	)	PUNCT
admet-1037	81	22	,	,	PUNCT
admet-1037	81	23	ciap2	ciap2	PROPN
admet-1037	81	24	/	/	SYM
admet-1037	81	25	birc3	birc3	NOUN
admet-1037	82	1	(	(	PUNCT
admet-1037	82	2	3	3	NUM
admet-1037	82	3	%	%	NOUN
admet-1037	82	4	)	)	PUNCT
admet-1037	83	1	and	and	CCONJ
admet-1037	83	2	unspecified	unspecified	ADJ
admet-1037	83	3	iaps	iap	NOUN
admet-1037	83	4	(	(	PUNCT
admet-1037	83	5	5	5	NUM
admet-1037	83	6	%	%	NOUN
admet-1037	83	7	)	)	PUNCT
admet-1037	83	8	,	,	PUNCT
admet-1037	83	9	revealing	reveal	VERB
admet-1037	83	10	the	the	DET
admet-1037	83	11	heterogenicity	heterogenicity	NOUN
admet-1037	83	12	of	of	ADP
admet-1037	83	13	this	this	DET
admet-1037	83	14	e3	e3	NOUN
admet-1037	83	15	ligase	ligase	NOUN
admet-1037	83	16	family	family	NOUN
admet-1037	83	17	.	.	PUNCT
admet-1037	84	1	consequently	consequently	ADV
admet-1037	84	2	,	,	PUNCT
admet-1037	84	3	snipers	sniper	NOUN
admet-1037	84	4	(	(	PUNCT
admet-1037	84	5	specific	specific	ADJ
admet-1037	84	6	and	and	CCONJ
admet-1037	84	7	nongenetic	nongenetic	ADJ
admet-1037	84	8	iap	iap	PROPN
admet-1037	84	9	-	-	PUNCT
admet-1037	84	10	based	base	VERB
admet-1037	84	11	protein	protein	NOUN
admet-1037	84	12	erasers	eraser	NOUN
admet-1037	84	13	)	)	PUNCT
admet-1037	84	14	are	be	AUX
admet-1037	84	15	rising	rise	VERB
admet-1037	84	16	as	as	ADP
admet-1037	84	17	degraders	degrader	NOUN
admet-1037	84	18	using	use	VERB
admet-1037	84	19	a	a	DET
admet-1037	84	20	high	high	ADJ
admet-1037	84	21	variability	variability	NOUN
admet-1037	84	22	of	of	ADP
admet-1037	84	23	e3	e3	NOUN
admet-1037	84	24	ligase	ligase	ADJ
admet-1037	84	25	proteins	protein	NOUN
admet-1037	84	26	[	[	X
admet-1037	84	27	22	22	NUM
admet-1037	84	28	]	]	PUNCT
admet-1037	84	29	.	.	PUNCT
admet-1037	85	1	finally	finally	ADV
admet-1037	85	2	,	,	PUNCT
admet-1037	85	3	crbn	crbn	NOUN
admet-1037	85	4	(	(	PUNCT
admet-1037	85	5	14	14	NUM
admet-1037	85	6	%	%	NOUN
admet-1037	85	7	)	)	PUNCT
admet-1037	85	8	and	and	CCONJ
admet-1037	85	9	mdm2	mdm2	PROPN
admet-1037	85	10	(	(	PUNCT
admet-1037	85	11	7	7	NUM
admet-1037	85	12	%	%	NOUN
admet-1037	85	13	)	)	PUNCT
admet-1037	85	14	gain	gain	VERB
admet-1037	85	15	the	the	DET
admet-1037	85	16	podium	podium	NOUN
admet-1037	85	17	of	of	ADP
admet-1037	85	18	e3	e3	NOUN
admet-1037	85	19	ligase	ligase	ADJ
admet-1037	85	20	proteins	protein	NOUN
admet-1037	85	21	(	(	PUNCT
admet-1037	85	22	fig	fig	NOUN
admet-1037	85	23	.	.	PUNCT
admet-1037	86	1	3b	3b	NUM
admet-1037	86	2	)	)	PUNCT
admet-1037	86	3	.	.	PUNCT
admet-1037	87	1	this	this	DET
admet-1037	87	2	result	result	NOUN
admet-1037	87	3	reveals	reveal	VERB
admet-1037	87	4	the	the	DET
admet-1037	87	5	reduced	reduced	ADJ
admet-1037	87	6	variety	variety	NOUN
admet-1037	87	7	of	of	ADP
admet-1037	87	8	e3	e3	NOUN
admet-1037	87	9	ligases	ligase	NOUN
admet-1037	87	10	and	and	CCONJ
admet-1037	87	11	the	the	DET
admet-1037	87	12	limited	limited	ADJ
admet-1037	87	13	choice	choice	NOUN
admet-1037	87	14	of	of	ADP
admet-1037	87	15	e3	e3	NOUN
admet-1037	87	16	ligands	ligand	NOUN
admet-1037	87	17	when	when	SCONJ
admet-1037	87	18	designing	design	VERB
admet-1037	87	19	new	new	ADJ
admet-1037	87	20	protacs	protac	NOUN
admet-1037	87	21	®	®	NOUN
admet-1037	87	22	.	.	PUNCT
admet-1037	88	1	moreover	moreover	ADV
admet-1037	88	2	,	,	PUNCT
admet-1037	88	3	despite	despite	SCONJ
admet-1037	88	4	the	the	DET
admet-1037	88	5	higher	high	ADJ
admet-1037	88	6	number	number	NOUN
admet-1037	88	7	of	of	ADP
admet-1037	88	8	known	know	VERB
admet-1037	88	9	iap	iap	PROPN
admet-1037	88	10	ligands	ligand	NOUN
admet-1037	88	11	compared	compare	VERB
admet-1037	88	12	to	to	ADP
admet-1037	88	13	crbn	crbn	NOUN
admet-1037	88	14	ligands	ligand	NOUN
admet-1037	88	15	,	,	PUNCT
admet-1037	88	16	just	just	ADV
admet-1037	88	17	1	1	NUM
admet-1037	88	18	crbn	crbn	NOUN
admet-1037	88	19	e3	e3	NOUN
admet-1037	88	20	ligand	ligand	NOUN
admet-1037	88	21	,	,	PUNCT
admet-1037	88	22	pomalidomide	pomalidomide	NOUN
admet-1037	88	23	,	,	PUNCT
admet-1037	88	24	is	be	AUX
admet-1037	88	25	used	use	VERB
admet-1037	88	26	in	in	ADP
admet-1037	88	27	1366	1366	NUM
admet-1037	88	28	out	out	ADP
admet-1037	88	29	of	of	ADP
admet-1037	88	30	the	the	DET
admet-1037	88	31	3939	3939	NUM
admet-1037	88	32	protac	protac	ADJ
admet-1037	88	33	®	®	NOUN
admet-1037	88	34	entries	entry	NOUN
admet-1037	88	35	(	(	PUNCT
admet-1037	88	36	35	35	NUM
admet-1037	88	37	%	%	NOUN
admet-1037	88	38	)	)	PUNCT
admet-1037	88	39	.	.	PUNCT
admet-1037	89	1	this	this	DET
admet-1037	89	2	fact	fact	NOUN
admet-1037	89	3	confirms	confirm	VERB
admet-1037	89	4	that	that	SCONJ
admet-1037	89	5	crbn	crbn	NOUN
admet-1037	89	6	is	be	AUX
admet-1037	89	7	one	one	NUM
admet-1037	89	8	of	of	ADP
admet-1037	89	9	the	the	DET
admet-1037	89	10	most	most	ADV
admet-1037	89	11	used	used	ADJ
admet-1037	89	12	e3	e3	NOUN
admet-1037	89	13	ligases	ligase	NOUN
admet-1037	89	14	for	for	ADP
admet-1037	89	15	protacs	protac	NOUN
admet-1037	89	16	,	,	PUNCT
admet-1037	89	17	despite	despite	SCONJ
admet-1037	89	18	crbn´s	crbn´	NOUN
admet-1037	89	19	reduced	reduce	VERB
admet-1037	89	20	e3	e3	NOUN
admet-1037	89	21	ligand	ligand	ADJ
admet-1037	89	22	choice	choice	NOUN
admet-1037	89	23	range	range	NOUN
admet-1037	89	24	.	.	PUNCT
admet-1037	90	1	consequently	consequently	ADV
admet-1037	90	2	,	,	PUNCT
admet-1037	90	3	due	due	ADP
admet-1037	90	4	to	to	ADP
admet-1037	90	5	the	the	DET
admet-1037	90	6	heterogenicity	heterogenicity	NOUN
admet-1037	90	7	of	of	ADP
admet-1037	90	8	the	the	DET
admet-1037	90	9	iap	iap	PROPN
admet-1037	90	10	family	family	PROPN
admet-1037	90	11	and	and	CCONJ
admet-1037	90	12	the	the	DET
admet-1037	90	13	great	great	ADJ
admet-1037	90	14	variability	variability	NOUN
admet-1037	90	15	of	of	ADP
admet-1037	90	16	iap	iap	PROPN
admet-1037	90	17	ligands	ligand	NOUN
admet-1037	90	18	,	,	PUNCT
admet-1037	90	19	it	it	PRON
admet-1037	90	20	is	be	AUX
admet-1037	90	21	expected	expect	VERB
admet-1037	90	22	that	that	SCONJ
admet-1037	90	23	iap	iap	PROPN
admet-1037	90	24	recruiting	recruit	VERB
admet-1037	90	25	protacs	protac	NOUN
admet-1037	90	26	®	®	NOUN
admet-1037	90	27	provide	provide	VERB
admet-1037	90	28	alternative	alternative	ADJ
admet-1037	90	29	tools	tool	NOUN
admet-1037	90	30	in	in	ADP
admet-1037	90	31	the	the	DET
admet-1037	90	32	near	near	ADJ
admet-1037	90	33	future	future	NOUN
admet-1037	90	34	.	.	PUNCT
admet-1037	91	1	figure	figure	NOUN
admet-1037	91	2	2	2	NUM
admet-1037	91	3	.	.	NOUN
admet-1037	91	4	histogram	histogram	NOUN
admet-1037	91	5	representation	representation	NOUN
admet-1037	91	6	of	of	ADP
admet-1037	91	7	a	a	DET
admet-1037	91	8	)	)	PUNCT
admet-1037	91	9	e3	e3	NOUN
admet-1037	91	10	ligase	ligase	ADJ
admet-1037	91	11	protein	protein	NOUN
admet-1037	91	12	families	family	NOUN
admet-1037	91	13	and	and	CCONJ
admet-1037	91	14	b	b	X
admet-1037	91	15	)	)	PUNCT
admet-1037	91	16	e3	e3	NOUN
admet-1037	91	17	ligases	ligase	NOUN
admet-1037	91	18	.	.	PUNCT
admet-1037	92	1	frequencies	frequency	NOUN
admet-1037	92	2	and	and	CCONJ
admet-1037	92	3	percentages	percentage	NOUN
admet-1037	92	4	are	be	AUX
admet-1037	92	5	calculated	calculate	VERB
admet-1037	92	6	.	.	PUNCT
admet-1037	93	1	values	value	NOUN
admet-1037	93	2	below	below	ADP
admet-1037	93	3	5	5	NUM
admet-1037	93	4	%	%	NOUN
admet-1037	93	5	for	for	ADP
admet-1037	93	6	e3	e3	NOUN
admet-1037	93	7	ligase	ligase	NOUN
admet-1037	93	8	families	family	NOUN
admet-1037	93	9	and	and	CCONJ
admet-1037	93	10	e3	e3	NOUN
admet-1037	93	11	ligases	ligase	NOUN
admet-1037	93	12	are	be	AUX
admet-1037	93	13	not	not	PART
admet-1037	93	14	represented	represent	VERB
admet-1037	93	15	.	.	PUNCT
admet-1037	94	1	warheads	warhead	NOUN
admet-1037	94	2	,	,	PUNCT
admet-1037	94	3	on	on	ADP
admet-1037	94	4	the	the	DET
admet-1037	94	5	other	other	ADJ
admet-1037	94	6	hand	hand	NOUN
admet-1037	94	7	,	,	PUNCT
admet-1037	94	8	have	have	VERB
admet-1037	94	9	a	a	DET
admet-1037	94	10	more	more	ADV
admet-1037	94	11	heterogeneous	heterogeneous	ADJ
admet-1037	94	12	distribution	distribution	NOUN
admet-1037	94	13	(	(	PUNCT
admet-1037	94	14	fig	fig	NOUN
admet-1037	94	15	.	.	PUNCT
admet-1037	95	1	3	3	NUM
admet-1037	95	2	)	)	PUNCT
admet-1037	95	3	in	in	ADP
admet-1037	95	4	which	which	PRON
admet-1037	95	5	121	121	NUM
admet-1037	95	6	warhead	warhead	NOUN
admet-1037	95	7	entries	entry	NOUN
admet-1037	95	8	target	target	VERB
admet-1037	95	9	the	the	DET
admet-1037	95	10	cdc2	cdc2	NOUN
admet-1037	95	11	/	/	SYM
admet-1037	95	12	cdkx	cdkx	NOUN
admet-1037	95	13	protein	protein	NOUN
admet-1037	95	14	kinases	kinase	NOUN
admet-1037	95	15	subfamily	subfamily	ADV
admet-1037	95	16	(	(	PUNCT
admet-1037	95	17	12	12	NUM
admet-1037	95	18	%	%	NOUN
admet-1037	95	19	)	)	PUNCT
admet-1037	95	20	,	,	PUNCT
admet-1037	95	21	39	39	NUM
admet-1037	95	22	mapk	mapk	NOUN
admet-1037	95	23	(	(	PUNCT
admet-1037	95	24	4	4	NUM
admet-1037	95	25	%	%	NOUN
admet-1037	95	26	)	)	PUNCT
admet-1037	95	27	,	,	PUNCT
admet-1037	95	28	38	38	NUM
admet-1037	95	29	serine	serine	NOUN
admet-1037	95	30	/	/	SYM
admet-1037	95	31	threonineprotein	threonineprotein	NOUN
admet-1037	95	32	kinases	kinase	NOUN
admet-1037	95	33	(	(	PUNCT
admet-1037	95	34	stk	stk	PROPN
admet-1037	95	35	)	)	PUNCT
admet-1037	95	36	(	(	PUNCT
admet-1037	95	37	4	4	NUM
admet-1037	95	38	%	%	NOUN
admet-1037	95	39	)	)	PUNCT
admet-1037	95	40	,	,	PUNCT
admet-1037	95	41	33	33	NUM
admet-1037	95	42	nuclear	nuclear	ADJ
admet-1037	95	43	hormone	hormone	NOUN
admet-1037	95	44	receptor	receptor	NOUN
admet-1037	95	45	(	(	PUNCT
admet-1037	95	46	nhr	nhr	PROPN
admet-1037	95	47	)	)	PUNCT
admet-1037	95	48	(	(	PUNCT
admet-1037	95	49	3	3	NUM
admet-1037	95	50	%	%	NOUN
admet-1037	95	51	)	)	PUNCT
admet-1037	95	52	and	and	CCONJ
admet-1037	95	53	28	28	NUM
admet-1037	95	54	bromodomain	bromodomain	NOUN
admet-1037	95	55	and	and	CCONJ
admet-1037	95	56	extraterminal	extraterminal	ADJ
admet-1037	95	57	(	(	PUNCT
admet-1037	95	58	bet	bet	NOUN
admet-1037	95	59	)	)	PUNCT
admet-1037	95	60	domain	domain	NOUN
admet-1037	95	61	family	family	NOUN
admet-1037	95	62	(	(	PUNCT
admet-1037	95	63	3	3	NUM
admet-1037	95	64	%	%	NOUN
admet-1037	95	65	)	)	PUNCT
admet-1037	95	66	(	(	PUNCT
admet-1037	95	67	fig	fig	NOUN
admet-1037	95	68	.	.	PUNCT
admet-1037	95	69	3a	3a	NUM
admet-1037	95	70	)	)	PUNCT
admet-1037	95	71	.	.	PUNCT
admet-1037	96	1	additionally	additionally	ADV
admet-1037	96	2	,	,	PUNCT
admet-1037	96	3	the	the	DET
admet-1037	96	4	androgen	androgen	NOUN
admet-1037	96	5	receptor	receptor	NOUN
admet-1037	96	6	(	(	PUNCT
admet-1037	96	7	ar	ar	NOUN
admet-1037	96	8	)	)	PUNCT
admet-1037	96	9	(	(	PUNCT
admet-1037	96	10	2	2	NUM
admet-1037	96	11	%	%	NOUN
admet-1037	96	12	)	)	PUNCT
admet-1037	96	13	,	,	PUNCT
admet-1037	96	14	aurka	aurka	NOUN
admet-1037	96	15	(	(	PUNCT
admet-1037	96	16	2	2	NUM
admet-1037	96	17	%	%	NOUN
admet-1037	96	18	)	)	PUNCT
admet-1037	96	19	,	,	PUNCT
admet-1037	96	20	cdk4	cdk4	NOUN
admet-1037	96	21	(	(	PUNCT
admet-1037	96	22	2	2	NUM
admet-1037	96	23	%	%	NOUN
admet-1037	96	24	)	)	PUNCT
admet-1037	96	25	,	,	PUNCT
admet-1037	96	26	cdk9	cdk9	PROPN
admet-1037	96	27	(	(	PUNCT
admet-1037	96	28	2	2	NUM
admet-1037	96	29	%	%	NOUN
admet-1037	96	30	)	)	PUNCT
admet-1037	96	31	and	and	CCONJ
admet-1037	96	32	brd4	brd4	NOUN
admet-1037	96	33	(	(	PUNCT
admet-1037	96	34	2	2	NUM
admet-1037	96	35	%	%	NOUN
admet-1037	96	36	)	)	PUNCT
admet-1037	96	37	,	,	PUNCT
admet-1037	96	38	represent	represent	VERB
admet-1037	96	39	the	the	DET
admet-1037	96	40	most	most	ADV
admet-1037	96	41	targeted	target	VERB
admet-1037	96	42	proteins	protein	NOUN
admet-1037	96	43	,	,	PUNCT
admet-1037	96	44	although	although	SCONJ
admet-1037	96	45	the	the	DET
admet-1037	96	46	distribution	distribution	NOUN
admet-1037	96	47	is	be	AUX
admet-1037	96	48	almost	almost	ADV
admet-1037	96	49	equal	equal	ADJ
admet-1037	96	50	for	for	ADP
admet-1037	96	51	all	all	DET
admet-1037	96	52	the	the	DET
admet-1037	96	53	proteins	protein	NOUN
admet-1037	96	54	targeted	target	VERB
admet-1037	96	55	by	by	ADP
admet-1037	96	56	warheads	warhead	NOUN
admet-1037	96	57	.	.	PUNCT
admet-1037	97	1	since	since	SCONJ
admet-1037	97	2	the	the	DET
admet-1037	97	3	protein	protein	NOUN
admet-1037	97	4	of	of	ADP
admet-1037	97	5	interest	interest	NOUN
admet-1037	97	6	will	will	AUX
admet-1037	97	7	ultimately	ultimately	ADV
admet-1037	97	8	determine	determine	VERB
admet-1037	97	9	the	the	DET
admet-1037	97	10	potential	potential	ADJ
admet-1037	97	11	therapeutic	therapeutic	ADJ
admet-1037	97	12	use	use	NOUN
admet-1037	97	13	of	of	ADP
admet-1037	97	14	a	a	DET
admet-1037	97	15	degrader	degrader	NOUN
admet-1037	97	16	,	,	PUNCT
admet-1037	97	17	the	the	DET
admet-1037	97	18	discovery	discovery	NOUN
admet-1037	97	19	of	of	ADP
admet-1037	97	20	new	new	ADJ
admet-1037	97	21	“	"	PUNCT
admet-1037	97	22	undruggable	undruggable	ADJ
admet-1037	97	23	”	"	PUNCT
admet-1037	97	24	targets	target	NOUN
admet-1037	97	25	justifies	justify	VERB
admet-1037	97	26	this	this	DET
admet-1037	97	27	heterogeneous	heterogeneous	ADJ
admet-1037	97	28	pattern	pattern	NOUN
admet-1037	97	29	.	.	PUNCT
admet-1037	98	1	figure	figure	NOUN
admet-1037	98	2	3	3	NUM
admet-1037	98	3	.	.	PUNCT
admet-1037	98	4	histogram	histogram	NOUN
admet-1037	98	5	representation	representation	NOUN
admet-1037	98	6	of	of	ADP
admet-1037	98	7	a	a	DET
admet-1037	98	8	)	)	PUNCT
admet-1037	98	9	poi	poi	PROPN
admet-1037	98	10	families	family	NOUN
admet-1037	98	11	and	and	CCONJ
admet-1037	98	12	b	b	X
admet-1037	98	13	)	)	PUNCT
admet-1037	98	14	poi	poi	NOUN
admet-1037	98	15	targeted	target	VERB
admet-1037	98	16	by	by	ADP
admet-1037	98	17	warheads	warhead	NOUN
admet-1037	98	18	.	.	PUNCT
admet-1037	99	1	frequencies	frequency	NOUN
admet-1037	99	2	and	and	CCONJ
admet-1037	99	3	percentages	percentage	NOUN
admet-1037	99	4	are	be	AUX
admet-1037	99	5	calculated	calculate	VERB
admet-1037	99	6	.	.	PUNCT
admet-1037	100	1	values	value	NOUN
admet-1037	100	2	below	below	ADP
admet-1037	100	3	3	3	NUM
admet-1037	100	4	%	%	NOUN
admet-1037	100	5	for	for	ADP
admet-1037	100	6	poi	poi	PROPN
admet-1037	100	7	families	family	NOUN
admet-1037	100	8	and	and	CCONJ
admet-1037	100	9	1	1	NUM
admet-1037	100	10	%	%	NOUN
admet-1037	100	11	for	for	ADP
admet-1037	100	12	poi	poi	PROPN
admet-1037	100	13	are	be	AUX
admet-1037	100	14	not	not	PART
admet-1037	100	15	represented	represent	VERB
admet-1037	100	16	.	.	PUNCT
admet-1037	101	1	regarding	regard	VERB
admet-1037	101	2	the	the	DET
admet-1037	101	3	3939	3939	NUM
admet-1037	101	4	protac	protac	ADJ
admet-1037	101	5	®	®	NOUN
admet-1037	101	6	entries	entry	NOUN
admet-1037	101	7	(	(	PUNCT
admet-1037	101	8	fig	fig	NOUN
admet-1037	101	9	.	.	PUNCT
admet-1037	101	10	4	4	NUM
admet-1037	101	11	)	)	PUNCT
admet-1037	101	12	,	,	PUNCT
admet-1037	101	13	507	507	NUM
admet-1037	101	14	target	target	NOUN
admet-1037	101	15	cdc2	cdc2	NOUN
admet-1037	101	16	/	/	SYM
admet-1037	101	17	cdkx	cdkx	NOUN
admet-1037	101	18	family	family	NOUN
admet-1037	101	19	proteins	protein	NOUN
admet-1037	101	20	(	(	PUNCT
admet-1037	101	21	23	23	NUM
admet-1037	101	22	%	%	NOUN
admet-1037	101	23	)	)	PUNCT
admet-1037	101	24	,	,	PUNCT
admet-1037	101	25	336	336	NUM
admet-1037	101	26	nuclear	nuclear	ADJ
admet-1037	101	27	hormone	hormone	NOUN
admet-1037	101	28	receptors	receptor	NOUN
admet-1037	101	29	(	(	PUNCT
admet-1037	101	30	15	15	NUM
admet-1037	101	31	%	%	NOUN
admet-1037	101	32	)	)	PUNCT
admet-1037	101	33	325	325	NUM
admet-1037	101	34	target	target	NOUN
admet-1037	101	35	bromodomain	bromodomain	NOUN
admet-1037	101	36	and	and	CCONJ
admet-1037	101	37	extra	extra	ADJ
admet-1037	101	38	-	-	ADJ
admet-1037	101	39	terminal	terminal	ADJ
admet-1037	101	40	(	(	PUNCT
admet-1037	101	41	bet	bet	NOUN
admet-1037	101	42	)	)	PUNCT
admet-1037	101	43	domains	domain	NOUN
admet-1037	101	44	(	(	PUNCT
admet-1037	101	45	15	15	NUM
admet-1037	101	46	%	%	NOUN
admet-1037	101	47	)	)	PUNCT
admet-1037	101	48	,	,	PUNCT
admet-1037	101	49	307	307	NUM
admet-1037	101	50	map	map	NOUN
admet-1037	101	51	admet	admet	PROPN
admet-1037	101	52	&	&	CCONJ
admet-1037	101	53	dmpk	dmpk	PROPN
admet-1037	101	54	9(4	9(4	PROPN
admet-1037	101	55	)	)	PUNCT
admet-1037	101	56	(	(	PUNCT
admet-1037	101	57	2021	2021	NUM
admet-1037	101	58	)	)	PUNCT
admet-1037	101	59	243	243	NUM
admet-1037	101	60	-	-	SYM
admet-1037	101	61	254	254	NUM
admet-1037	101	62	are	be	AUX
admet-1037	101	63	we	we	PRON
admet-1037	101	64	ready	ready	ADJ
admet-1037	101	65	to	to	PART
admet-1037	101	66	design	design	VERB
admet-1037	101	67	oral	oral	ADJ
admet-1037	101	68	protacs	protacs	PROPN
admet-1037	101	69	®	®	NOUN
admet-1037	101	70	?	?	PUNCT
admet-1037	102	1	doi	doi	NOUN
admet-1037	102	2	:	:	PUNCT
admet-1037	102	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	NUM
admet-1037	102	4	247	247	NUM
admet-1037	102	5	kinases	kinase	NOUN
admet-1037	102	6	(	(	PUNCT
admet-1037	102	7	mapk	mapk	NOUN
admet-1037	102	8	)	)	PUNCT
admet-1037	102	9	(	(	PUNCT
admet-1037	102	10	14	14	NUM
admet-1037	102	11	%	%	NOUN
admet-1037	102	12	)	)	PUNCT
admet-1037	102	13	,	,	PUNCT
admet-1037	102	14	144	144	NUM
admet-1037	102	15	epithelial	epithelial	ADJ
admet-1037	102	16	growth	growth	NOUN
admet-1037	102	17	factor	factor	NOUN
admet-1037	102	18	receptors	receptor	NOUN
admet-1037	102	19	(	(	PUNCT
admet-1037	102	20	egfr	egfr	X
admet-1037	102	21	)	)	PUNCT
admet-1037	102	22	(	(	PUNCT
admet-1037	102	23	7	7	NUM
admet-1037	102	24	%	%	NOUN
admet-1037	102	25	)	)	PUNCT
admet-1037	102	26	and	and	CCONJ
admet-1037	102	27	139	139	NUM
admet-1037	102	28	the	the	DET
admet-1037	102	29	insulin	insulin	NOUN
admet-1037	102	30	receptor	receptor	NOUN
admet-1037	102	31	family	family	NOUN
admet-1037	102	32	(	(	PUNCT
admet-1037	102	33	6	6	NUM
admet-1037	102	34	%	%	NOUN
admet-1037	102	35	)	)	PUNCT
admet-1037	102	36	,	,	PUNCT
admet-1037	102	37	(	(	PUNCT
admet-1037	102	38	figure	figure	NOUN
admet-1037	102	39	4a	4a	NUM
admet-1037	102	40	)	)	PUNCT
admet-1037	102	41	.	.	PUNCT
admet-1037	103	1	in	in	ADP
admet-1037	103	2	addition	addition	NOUN
admet-1037	103	3	,	,	PUNCT
admet-1037	103	4	the	the	DET
admet-1037	103	5	study	study	NOUN
admet-1037	103	6	reflects	reflect	VERB
admet-1037	103	7	that	that	SCONJ
admet-1037	103	8	5	5	NUM
admet-1037	103	9	%	%	NOUN
admet-1037	103	10	of	of	ADP
admet-1037	103	11	published	publish	VERB
admet-1037	103	12	protacs	protac	NOUN
admet-1037	103	13	®	®	NOUN
admet-1037	103	14	target	target	VERB
admet-1037	103	15	the	the	DET
admet-1037	103	16	estrogen	estrogen	NOUN
admet-1037	103	17	receptor	receptor	NOUN
admet-1037	103	18	(	(	PUNCT
admet-1037	103	19	er	er	INTJ
admet-1037	103	20	)	)	PUNCT
admet-1037	103	21	,	,	PUNCT
admet-1037	103	22	4	4	NUM
admet-1037	103	23	%	%	NOUN
admet-1037	103	24	brd4	brd4	NOUN
admet-1037	103	25	,	,	PUNCT
admet-1037	103	26	4	4	NUM
admet-1037	103	27	%	%	NOUN
admet-1037	103	28	cdk4	cdk4	NOUN
admet-1037	103	29	,	,	PUNCT
admet-1037	103	30	4	4	NUM
admet-1037	103	31	%	%	NOUN
admet-1037	103	32	the	the	DET
admet-1037	103	33	ar	ar	NOUN
admet-1037	103	34	and	and	CCONJ
admet-1037	103	35	4	4	NUM
admet-1037	103	36	%	%	NOUN
admet-1037	103	37	cdk6	cdk6	NOUN
admet-1037	103	38	.	.	PUNCT
admet-1037	104	1	moreover	moreover	ADV
admet-1037	104	2	,	,	PUNCT
admet-1037	104	3	the	the	DET
admet-1037	104	4	wide	wide	ADJ
admet-1037	104	5	variety	variety	NOUN
admet-1037	104	6	of	of	ADP
admet-1037	104	7	poi	poi	PROPN
admet-1037	104	8	targeted	target	VERB
admet-1037	104	9	by	by	ADP
admet-1037	104	10	warheads	warhead	NOUN
admet-1037	104	11	justifies	justify	VERB
admet-1037	104	12	the	the	DET
admet-1037	104	13	heterogeneous	heterogeneous	ADJ
admet-1037	104	14	and	and	CCONJ
admet-1037	104	15	scattered	scatter	VERB
admet-1037	104	16	poi	poi	PROPN
admet-1037	104	17	profile	profile	NOUN
admet-1037	104	18	targeted	target	VERB
admet-1037	104	19	by	by	ADP
admet-1037	104	20	protacs	protac	NOUN
admet-1037	104	21	.	.	PUNCT
admet-1037	105	1	notably	notably	ADV
admet-1037	105	2	,	,	PUNCT
admet-1037	105	3	protacdb	protacdb	PROPN
admet-1037	105	4	does	do	AUX
admet-1037	105	5	not	not	PART
admet-1037	105	6	include	include	VERB
admet-1037	105	7	most	most	ADJ
admet-1037	105	8	proprietary	proprietary	ADJ
admet-1037	105	9	compounds	compound	NOUN
admet-1037	105	10	and	and	CCONJ
admet-1037	105	11	thus	thus	ADV
admet-1037	105	12	we	we	PRON
admet-1037	105	13	expect	expect	VERB
admet-1037	105	14	that	that	SCONJ
admet-1037	105	15	warheads	warhead	NOUN
admet-1037	105	16	may	may	AUX
admet-1037	105	17	cover	cover	VERB
admet-1037	105	18	more	more	ADJ
admet-1037	105	19	poi	poi	PROPN
admet-1037	105	20	families	family	NOUN
admet-1037	105	21	.	.	PUNCT
admet-1037	106	1	figure	figure	VERB
admet-1037	106	2	4	4	NUM
admet-1037	106	3	.	.	NOUN
admet-1037	106	4	histogram	histogram	NOUN
admet-1037	106	5	representation	representation	NOUN
admet-1037	106	6	of	of	ADP
admet-1037	106	7	a	a	DET
admet-1037	106	8	)	)	PUNCT
admet-1037	106	9	poi	poi	PROPN
admet-1037	106	10	families	family	NOUN
admet-1037	106	11	and	and	CCONJ
admet-1037	106	12	b	b	X
admet-1037	106	13	)	)	PUNCT
admet-1037	106	14	poi	poi	NOUN
admet-1037	106	15	targeted	target	VERB
admet-1037	106	16	by	by	ADP
admet-1037	106	17	protacs	protac	NOUN
admet-1037	106	18	®	®	NOUN
admet-1037	106	19	.	.	PUNCT
admet-1037	107	1	frequencies	frequency	NOUN
admet-1037	107	2	and	and	CCONJ
admet-1037	107	3	percentages	percentage	NOUN
admet-1037	107	4	are	be	AUX
admet-1037	107	5	calculated	calculate	VERB
admet-1037	107	6	.	.	PUNCT
admet-1037	108	1	values	value	NOUN
admet-1037	108	2	below	below	ADP
admet-1037	108	3	6	6	NUM
admet-1037	108	4	%	%	NOUN
admet-1037	108	5	for	for	ADP
admet-1037	108	6	poi	poi	PROPN
admet-1037	108	7	families	family	NOUN
admet-1037	108	8	and	and	CCONJ
admet-1037	108	9	2	2	NUM
admet-1037	108	10	%	%	NOUN
admet-1037	108	11	for	for	ADP
admet-1037	108	12	poi	poi	PROPN
admet-1037	108	13	are	be	AUX
admet-1037	108	14	not	not	PART
admet-1037	108	15	represented	represent	VERB
admet-1037	108	16	.	.	PUNCT
admet-1037	109	1	one	one	NUM
admet-1037	109	2	protac	protac	ADJ
admet-1037	109	3	®	®	NOUN
admet-1037	109	4	chemical	chemical	NOUN
admet-1037	109	5	space	space	NOUN
admet-1037	109	6	the	the	DET
admet-1037	109	7	most	most	ADV
admet-1037	109	8	current	current	ADJ
admet-1037	109	9	definition	definition	NOUN
admet-1037	109	10	of	of	ADP
admet-1037	109	11	chemical	chemical	ADJ
admet-1037	109	12	space	space	NOUN
admet-1037	109	13	is	be	AUX
admet-1037	109	14	the	the	DET
admet-1037	109	15	ensemble	ensemble	ADJ
admet-1037	109	16	of	of	ADP
admet-1037	109	17	all	all	DET
admet-1037	109	18	possible	possible	ADJ
admet-1037	109	19	synthesizable	synthesizable	ADJ
admet-1037	109	20	molecules	molecule	NOUN
admet-1037	109	21	.	.	PUNCT
admet-1037	110	1	when	when	SCONJ
admet-1037	110	2	defining	define	VERB
admet-1037	110	3	as	as	SCONJ
admet-1037	110	4	bioactive	bioactive	VERB
admet-1037	110	5	any	any	DET
admet-1037	110	6	chemical	chemical	NOUN
admet-1037	110	7	entity	entity	NOUN
admet-1037	110	8	able	able	ADJ
admet-1037	110	9	to	to	PART
admet-1037	110	10	specifically	specifically	ADV
admet-1037	110	11	interfere	interfere	VERB
admet-1037	110	12	withand	withand	NOUN
admet-1037	110	13	alter	alter	VERB
admet-1037	110	14	biological	biological	ADJ
admet-1037	110	15	systems	system	NOUN
admet-1037	110	16	,	,	PUNCT
admet-1037	110	17	navigating	navigate	VERB
admet-1037	110	18	the	the	DET
admet-1037	110	19	chemical	chemical	NOUN
admet-1037	110	20	space	space	NOUN
admet-1037	110	21	to	to	PART
admet-1037	110	22	find	find	VERB
admet-1037	110	23	bioactive	bioactive	ADJ
admet-1037	110	24	compounds	compound	NOUN
admet-1037	110	25	sets	set	VERB
admet-1037	110	26	itself	itself	PRON
admet-1037	110	27	as	as	ADP
admet-1037	110	28	the	the	DET
admet-1037	110	29	primary	primary	ADJ
admet-1037	110	30	goal	goal	NOUN
admet-1037	110	31	of	of	ADP
admet-1037	110	32	medicinal	medicinal	ADJ
admet-1037	110	33	chemists	chemist	NOUN
admet-1037	110	34	.	.	PUNCT
admet-1037	111	1	unfortunately	unfortunately	ADV
admet-1037	111	2	,	,	PUNCT
admet-1037	111	3	this	this	PRON
admet-1037	111	4	is	be	AUX
admet-1037	111	5	not	not	PART
admet-1037	111	6	a	a	DET
admet-1037	111	7	trivial	trivial	ADJ
admet-1037	111	8	task	task	NOUN
admet-1037	111	9	,	,	PUNCT
admet-1037	111	10	since	since	SCONJ
admet-1037	111	11	the	the	DET
admet-1037	111	12	chemical	chemical	NOUN
admet-1037	111	13	space	space	NOUN
admet-1037	111	14	potentially	potentially	ADV
admet-1037	111	15	includes	include	VERB
admet-1037	111	16	more	more	ADJ
admet-1037	111	17	than	than	ADP
admet-1037	111	18	10180	10180	NUM
admet-1037	111	19	molecules	molecule	NOUN
admet-1037	111	20	,	,	PUNCT
admet-1037	111	21	[	[	X
admet-1037	111	22	23	23	NUM
admet-1037	111	23	]	]	PUNCT
admet-1037	111	24	.	.	PUNCT
admet-1037	112	1	in	in	ADP
admet-1037	112	2	order	order	NOUN
admet-1037	112	3	to	to	PART
admet-1037	112	4	give	give	VERB
admet-1037	112	5	a	a	DET
admet-1037	112	6	magnitude	magnitude	NOUN
admet-1037	112	7	-	-	PUNCT
admet-1037	112	8	order	order	NOUN
admet-1037	112	9	comparison	comparison	NOUN
admet-1037	112	10	,	,	PUNCT
admet-1037	112	11	the	the	DET
admet-1037	112	12	biggest	big	ADJ
admet-1037	112	13	structure	structure	NOUN
admet-1037	112	14	repository	repository	NOUN
admet-1037	112	15	from	from	ADP
admet-1037	112	16	the	the	DET
admet-1037	112	17	american	american	PROPN
admet-1037	112	18	chemical	chemical	PROPN
admet-1037	112	19	society	society	NOUN
admet-1037	112	20	“	"	PUNCT
admet-1037	112	21	just	just	ADV
admet-1037	112	22	”	"	PUNCT
admet-1037	112	23	contains	contain	VERB
admet-1037	112	24	108	108	NUM
admet-1037	112	25	structures	structure	NOUN
admet-1037	112	26	and	and	CCONJ
admet-1037	112	27	only	only	ADV
admet-1037	112	28	a	a	DET
admet-1037	112	29	thousand	thousand	NUM
admet-1037	112	30	are	be	AUX
admet-1037	112	31	bioactive	bioactive	ADJ
admet-1037	112	32	.	.	PUNCT
admet-1037	113	1	moreover	moreover	ADV
admet-1037	113	2	,	,	PUNCT
admet-1037	113	3	it	it	PRON
admet-1037	113	4	should	should	AUX
admet-1037	113	5	be	be	AUX
admet-1037	113	6	also	also	ADV
admet-1037	113	7	recalled	recall	VERB
admet-1037	113	8	that	that	PRON
admet-1037	113	9	bioactivity	bioactivity	NOUN
admet-1037	113	10	alone	alone	ADV
admet-1037	113	11	is	be	AUX
admet-1037	113	12	not	not	PART
admet-1037	113	13	sufficient	sufficient	ADJ
admet-1037	113	14	to	to	PART
admet-1037	113	15	allow	allow	VERB
admet-1037	113	16	a	a	DET
admet-1037	113	17	compound	compound	NOUN
admet-1037	113	18	to	to	PART
admet-1037	113	19	become	become	VERB
admet-1037	113	20	a	a	DET
admet-1037	113	21	drug	drug	NOUN
admet-1037	113	22	and	and	CCONJ
admet-1037	113	23	that	that	DET
admet-1037	113	24	oral	oral	ADJ
admet-1037	113	25	drug	drug	NOUN
admet-1037	113	26	delivery	delivery	NOUN
admet-1037	113	27	is	be	AUX
admet-1037	113	28	the	the	DET
admet-1037	113	29	most	most	ADV
admet-1037	113	30	preferred	preferred	ADJ
admet-1037	113	31	administration	administration	NOUN
admet-1037	113	32	route	route	NOUN
admet-1037	113	33	.	.	PUNCT
admet-1037	114	1	therefore	therefore	ADV
admet-1037	114	2	,	,	PUNCT
admet-1037	114	3	most	most	ADJ
admet-1037	114	4	bioactive	bioactive	ADJ
admet-1037	114	5	molecules	molecule	NOUN
admet-1037	114	6	(	(	PUNCT
admet-1037	114	7	often	often	ADV
admet-1037	114	8	known	know	VERB
admet-1037	114	9	as	as	ADP
admet-1037	114	10	chemical	chemical	NOUN
admet-1037	114	11	probes	probe	NOUN
admet-1037	114	12	)	)	PUNCT
admet-1037	114	13	do	do	AUX
admet-1037	114	14	not	not	PART
admet-1037	114	15	become	become	VERB
admet-1037	114	16	oral	oral	ADJ
admet-1037	114	17	drug	drug	NOUN
admet-1037	114	18	candidates	candidate	NOUN
admet-1037	114	19	because	because	SCONJ
admet-1037	114	20	of	of	ADP
admet-1037	114	21	the	the	DET
admet-1037	114	22	lack	lack	NOUN
admet-1037	114	23	of	of	ADP
admet-1037	114	24	an	an	DET
admet-1037	114	25	adequate	adequate	ADJ
admet-1037	114	26	adme	adme	NOUN
admet-1037	114	27	profile	profile	NOUN
admet-1037	114	28	.	.	PUNCT
admet-1037	115	1	in	in	ADP
admet-1037	115	2	general	general	ADJ
admet-1037	115	3	terms	term	NOUN
admet-1037	115	4	,	,	PUNCT
admet-1037	115	5	protacs	protac	NOUN
admet-1037	115	6	®	®	NOUN
admet-1037	115	7	occupy	occupy	VERB
admet-1037	115	8	a	a	DET
admet-1037	115	9	subregion	subregion	NOUN
admet-1037	115	10	of	of	ADP
admet-1037	115	11	the	the	DET
admet-1037	115	12	whole	whole	ADJ
admet-1037	115	13	chemical	chemical	NOUN
admet-1037	115	14	space	space	NOUN
admet-1037	115	15	that	that	PRON
admet-1037	115	16	can	can	AUX
admet-1037	115	17	be	be	AUX
admet-1037	115	18	called	call	VERB
admet-1037	115	19	the	the	DET
admet-1037	115	20	protac	protac	ADJ
admet-1037	115	21	®	®	NOUN
admet-1037	115	22	chemical	chemical	NOUN
admet-1037	115	23	space	space	NOUN
admet-1037	115	24	.	.	PUNCT
admet-1037	116	1	this	this	DET
admet-1037	116	2	region	region	NOUN
admet-1037	116	3	includes	include	VERB
admet-1037	116	4	both	both	DET
admet-1037	116	5	protacs	protac	NOUN
admet-1037	116	6	®	®	NOUN
admet-1037	116	7	with	with	ADP
admet-1037	116	8	no	no	DET
admet-1037	116	9	future	future	NOUN
admet-1037	116	10	as	as	ADP
admet-1037	116	11	drugs	drug	NOUN
admet-1037	116	12	(	(	PUNCT
admet-1037	116	13	either	either	CCONJ
admet-1037	116	14	inactive	inactive	ADJ
admet-1037	116	15	molecules	molecule	NOUN
admet-1037	116	16	or	or	CCONJ
admet-1037	116	17	chemical	chemical	NOUN
admet-1037	116	18	probes	probe	NOUN
admet-1037	116	19	)	)	PUNCT
admet-1037	116	20	and	and	CCONJ
admet-1037	116	21	protacs	protac	NOUN
admet-1037	116	22	®	®	NOUN
admet-1037	116	23	with	with	ADP
admet-1037	116	24	potential	potential	NOUN
admet-1037	116	25	as	as	ADP
admet-1037	116	26	oral	oral	ADJ
admet-1037	116	27	drug	drug	NOUN
admet-1037	116	28	candidates	candidate	NOUN
admet-1037	116	29	.	.	PUNCT
admet-1037	117	1	therefore	therefore	ADV
admet-1037	117	2	,	,	PUNCT
admet-1037	117	3	one	one	NUM
admet-1037	117	4	main	main	ADJ
admet-1037	117	5	aim	aim	NOUN
admet-1037	117	6	of	of	ADP
admet-1037	117	7	pharmaceutical	pharmaceutical	ADJ
admet-1037	117	8	research	research	NOUN
admet-1037	117	9	consists	consist	VERB
admet-1037	117	10	in	in	ADP
admet-1037	117	11	individuating	individuate	VERB
admet-1037	117	12	in	in	ADP
admet-1037	117	13	the	the	DET
admet-1037	117	14	early	early	ADJ
admet-1037	117	15	drug	drug	NOUN
admet-1037	117	16	discovery	discovery	NOUN
admet-1037	117	17	the	the	DET
admet-1037	117	18	protac	protac	ADJ
admet-1037	117	19	®	®	NOUN
admet-1037	117	20	chemical	chemical	NOUN
admet-1037	117	21	space	space	NOUN
admet-1037	117	22	subregions	subregion	NOUN
admet-1037	117	23	enriched	enrich	VERB
admet-1037	117	24	in	in	ADP
admet-1037	117	25	potential	potential	ADJ
admet-1037	117	26	drug	drug	NOUN
admet-1037	117	27	candidates	candidate	NOUN
admet-1037	117	28	(	(	PUNCT
admet-1037	117	29	fig	fig	NOUN
admet-1037	117	30	.	.	PUNCT
admet-1037	117	31	5	5	NUM
admet-1037	117	32	)	)	PUNCT
admet-1037	117	33	.	.	PUNCT
admet-1037	118	1	one	one	NUM
admet-1037	118	2	reasonable	reasonable	ADJ
admet-1037	118	3	way	way	NOUN
admet-1037	118	4	to	to	PART
admet-1037	118	5	do	do	VERB
admet-1037	118	6	this	this	PRON
admet-1037	118	7	is	be	AUX
admet-1037	118	8	to	to	PART
admet-1037	118	9	use	use	VERB
admet-1037	118	10	molecular	molecular	ADJ
admet-1037	118	11	properties	property	NOUN
admet-1037	118	12	.	.	PUNCT
admet-1037	119	1	molecular	molecular	ADJ
admet-1037	119	2	properties	property	NOUN
admet-1037	119	3	are	be	AUX
admet-1037	119	4	quantified	quantify	VERB
admet-1037	119	5	by	by	ADP
admet-1037	119	6	molecular	molecular	ADJ
admet-1037	119	7	descriptors	descriptor	NOUN
admet-1037	119	8	,	,	PUNCT
admet-1037	119	9	which	which	PRON
admet-1037	119	10	define	define	VERB
admet-1037	119	11	an	an	DET
admet-1037	119	12	n	n	ADV
admet-1037	119	13	-	-	PUNCT
admet-1037	119	14	dimensional	dimensional	ADJ
admet-1037	119	15	chemical	chemical	NOUN
admet-1037	119	16	space	space	NOUN
admet-1037	119	17	,	,	PUNCT
admet-1037	119	18	where	where	SCONJ
admet-1037	119	19	n	n	PRON
admet-1037	119	20	is	be	AUX
admet-1037	119	21	the	the	DET
admet-1037	119	22	number	number	NOUN
admet-1037	119	23	of	of	ADP
admet-1037	119	24	descriptors	descriptor	NOUN
admet-1037	119	25	considered	consider	VERB
admet-1037	119	26	.	.	PUNCT
admet-1037	120	1	molecular	molecular	ADJ
admet-1037	120	2	descriptors	descriptor	NOUN
admet-1037	120	3	are	be	AUX
admet-1037	120	4	in	in	ADP
admet-1037	120	5	this	this	DET
admet-1037	120	6	fashion	fashion	NOUN
admet-1037	120	7	the	the	DET
admet-1037	120	8	orienting	orienting	ADJ
admet-1037	120	9	coordinates	coordinate	NOUN
admet-1037	120	10	within	within	ADP
admet-1037	120	11	the	the	DET
admet-1037	120	12	chemical	chemical	NOUN
admet-1037	120	13	space	space	NOUN
admet-1037	120	14	and	and	CCONJ
admet-1037	120	15	retrospective	retrospective	ADJ
admet-1037	120	16	analysis	analysis	NOUN
admet-1037	120	17	of	of	ADP
admet-1037	120	18	already	already	ADV
admet-1037	120	19	known	know	VERB
admet-1037	120	20	compounds	compound	NOUN
admet-1037	120	21	individuates	individuate	VERB
admet-1037	120	22	regions	region	NOUN
admet-1037	120	23	of	of	ADP
admet-1037	120	24	interest	interest	NOUN
admet-1037	120	25	.	.	PUNCT
admet-1037	121	1	in	in	ADP
admet-1037	121	2	very	very	ADV
admet-1037	121	3	early	early	ADJ
admet-1037	121	4	drug	drug	NOUN
admet-1037	121	5	discovery	discovery	NOUN
admet-1037	121	6	stages	stage	NOUN
admet-1037	121	7	,	,	PUNCT
admet-1037	121	8	the	the	DET
admet-1037	121	9	chemical	chemical	NOUN
admet-1037	121	10	matter	matter	NOUN
admet-1037	121	11	is	be	AUX
admet-1037	121	12	not	not	PART
admet-1037	121	13	available	available	ADJ
admet-1037	121	14	and	and	CCONJ
admet-1037	121	15	therefore	therefore	ADV
admet-1037	121	16	in	in	ADP
admet-1037	121	17	silico	silico	NOUN
admet-1037	121	18	descriptors	descriptor	NOUN
admet-1037	121	19	are	be	AUX
admet-1037	121	20	used	use	VERB
admet-1037	121	21	at	at	ADP
admet-1037	121	22	the	the	DET
admet-1037	121	23	beginning	beginning	NOUN
admet-1037	121	24	of	of	ADP
admet-1037	121	25	any	any	DET
admet-1037	121	26	research	research	NOUN
admet-1037	121	27	program	program	NOUN
admet-1037	121	28	.	.	PUNCT
admet-1037	122	1	since	since	SCONJ
admet-1037	122	2	all	all	DET
admet-1037	122	3	molecular	molecular	ADJ
admet-1037	122	4	properties	property	NOUN
admet-1037	122	5	fundamentally	fundamentally	ADV
admet-1037	122	6	derive	derive	ADJ
admet-1037	122	7	from	from	ADP
admet-1037	122	8	the	the	DET
admet-1037	122	9	atom	atom	NOUN
admet-1037	122	10	quality	quality	NOUN
admet-1037	122	11	,	,	PUNCT
admet-1037	122	12	quantity	quantity	NOUN
admet-1037	122	13	and	and	CCONJ
admet-1037	122	14	connectivity	connectivity	NOUN
admet-1037	122	15	,	,	PUNCT
admet-1037	122	16	the	the	DET
admet-1037	122	17	first	first	ADJ
admet-1037	122	18	and	and	CCONJ
admet-1037	122	19	most	most	ADV
admet-1037	122	20	fundamental	fundamental	ADJ
admet-1037	122	21	descriptors	descriptor	NOUN
admet-1037	122	22	can	can	AUX
admet-1037	122	23	be	be	AUX
admet-1037	122	24	obtained	obtain	VERB
admet-1037	122	25	from	from	ADP
admet-1037	122	26	the	the	DET
admet-1037	122	27	molecular	molecular	ADJ
admet-1037	122	28	formula	formula	NOUN
admet-1037	122	29	,	,	PUNCT
admet-1037	122	30	such	such	ADJ
admet-1037	122	31	as	as	ADP
admet-1037	122	32	mass	mass	ADJ
admet-1037	122	33	weight	weight	NOUN
admet-1037	122	34	,	,	PUNCT
admet-1037	122	35	number	number	NOUN
admet-1037	122	36	of	of	ADP
admet-1037	122	37	atoms	atom	NOUN
admet-1037	122	38	,	,	PUNCT
admet-1037	122	39	number	number	NOUN
admet-1037	122	40	of	of	ADP
admet-1037	122	41	specific	specific	ADJ
admet-1037	122	42	elements	element	NOUN
admet-1037	122	43	,	,	PUNCT
admet-1037	122	44	etc	etc	X
admet-1037	122	45	.	.	X
admet-1037	122	46	one	one	NUM
admet-1037	122	47	level	level	NOUN
admet-1037	122	48	of	of	ADP
admet-1037	122	49	complexity	complexity	NOUN
admet-1037	122	50	above	above	ADP
admet-1037	122	51	this	this	PRON
admet-1037	122	52	involves	involve	VERB
admet-1037	122	53	the	the	DET
admet-1037	122	54	use	use	NOUN
admet-1037	122	55	of	of	ADP
admet-1037	122	56	atom	atom	NOUN
admet-1037	122	57	connectivity	connectivity	NOUN
admet-1037	122	58	-	-	PUNCT
admet-1037	122	59	related	relate	VERB
admet-1037	122	60	descriptors	descriptor	NOUN
admet-1037	122	61	.	.	PUNCT
admet-1037	123	1	to	to	ADP
admet-1037	123	2	date	date	NOUN
admet-1037	123	3	,	,	PUNCT
admet-1037	123	4	the	the	DET
admet-1037	123	5	definition	definition	NOUN
admet-1037	123	6	of	of	ADP
admet-1037	123	7	the	the	DET
admet-1037	123	8	classically	classically	ADV
admet-1037	123	9	intended	intend	VERB
admet-1037	123	10	”	"	PUNCT
admet-1037	123	11	drug	drug	NOUN
admet-1037	123	12	-	-	PUNCT
admet-1037	123	13	like	like	ADJ
admet-1037	123	14	”	"	PUNCT
admet-1037	123	15	chemical	chemical	NOUN
admet-1037	123	16	space	space	NOUN
admet-1037	123	17	(	(	PUNCT
admet-1037	123	18	defined	define	VERB
admet-1037	123	19	by	by	ADP
admet-1037	123	20	lipinski	lipinski	PROPN
admet-1037	123	21	’s	’s	PART
admet-1037	123	22	rule	rule	NOUN
admet-1037	123	23	of	of	ADP
admet-1037	123	24	five	five	NUM
admet-1037	123	25	,	,	PUNCT
admet-1037	123	26	ro5	ro5	NOUN
admet-1037	123	27	)	)	PUNCT
admet-1037	123	28	is	be	AUX
admet-1037	123	29	purely	purely	ADV
admet-1037	123	30	bordered	border	VERB
admet-1037	123	31	by	by	ADP
admet-1037	123	32	molecular	molecular	ADJ
admet-1037	123	33	descriptors	descriptor	NOUN
admet-1037	123	34	calculated	calculate	VERB
admet-1037	123	35	from	from	ADP
admet-1037	123	36	the	the	DET
admet-1037	123	37	structure	structure	NOUN
admet-1037	123	38	formula	formula	NOUN
admet-1037	123	39	,	,	PUNCT
admet-1037	123	40	referred	refer	VERB
admet-1037	123	41	as	as	ADP
admet-1037	123	42	2d	2d	NUM
admet-1037	123	43	descriptors	descriptor	NOUN
admet-1037	123	44	.	.	PUNCT
admet-1037	124	1	even	even	ADV
admet-1037	124	2	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	DET
admet-1037	124	3	g.	g.	PROPN
admet-1037	124	4	ermondi	ermondi	PROPN
admet-1037	124	5	et	et	PROPN
admet-1037	124	6	al	al	PROPN
admet-1037	124	7	.	.	PROPN
admet-1037	124	8	admet	admet	PROPN
admet-1037	124	9	&	&	CCONJ
admet-1037	124	10	dmpk	dmpk	PROPN
admet-1037	124	11	9(4	9(4	PROPN
admet-1037	124	12	)	)	PUNCT
admet-1037	124	13	(	(	PUNCT
admet-1037	124	14	2021	2021	NUM
admet-1037	124	15	)	)	PUNCT
admet-1037	124	16	243	243	NUM
admet-1037	124	17	-	-	SYM
admet-1037	124	18	254	254	NUM
admet-1037	124	19	248	248	NUM
admet-1037	124	20	though	though	SCONJ
admet-1037	124	21	the	the	DET
admet-1037	124	22	ro5	ro5	NOUN
admet-1037	124	23	still	still	ADV
admet-1037	124	24	represents	represent	VERB
admet-1037	124	25	the	the	DET
admet-1037	124	26	golden	golden	ADJ
admet-1037	124	27	region	region	NOUN
admet-1037	124	28	of	of	ADP
admet-1037	124	29	the	the	DET
admet-1037	124	30	chemical	chemical	NOUN
admet-1037	124	31	space	space	NOUN
admet-1037	124	32	for	for	ADP
admet-1037	124	33	small	small	ADJ
admet-1037	124	34	molecules	molecule	NOUN
admet-1037	124	35	,	,	PUNCT
admet-1037	124	36	more	more	ADJ
admet-1037	124	37	and	and	CCONJ
admet-1037	124	38	more	more	ADV
admet-1037	124	39	active	active	ADJ
admet-1037	124	40	compounds	compound	NOUN
admet-1037	124	41	discovered	discover	VERB
admet-1037	124	42	violate	violate	VERB
admet-1037	124	43	these	these	DET
admet-1037	124	44	guidelines	guideline	NOUN
admet-1037	124	45	.	.	PUNCT
admet-1037	125	1	this	this	PRON
admet-1037	125	2	occurs	occur	VERB
admet-1037	125	3	especially	especially	ADV
admet-1037	125	4	in	in	ADP
admet-1037	125	5	the	the	DET
admet-1037	125	6	case	case	NOUN
admet-1037	125	7	of	of	ADP
admet-1037	125	8	larger	large	ADJ
admet-1037	125	9	,	,	PUNCT
admet-1037	125	10	highly	highly	ADV
admet-1037	125	11	flexible	flexible	ADJ
admet-1037	125	12	structures	structure	NOUN
admet-1037	125	13	,	,	PUNCT
admet-1037	125	14	such	such	ADJ
admet-1037	125	15	as	as	ADP
admet-1037	125	16	protacs	protac	NOUN
admet-1037	125	17	®	®	NOUN
admet-1037	125	18	[	[	X
admet-1037	125	19	15	15	NUM
admet-1037	125	20	]	]	PUNCT
admet-1037	125	21	.	.	PUNCT
admet-1037	126	1	figure	figure	NOUN
admet-1037	126	2	5	5	NUM
admet-1037	126	3	.	.	PUNCT
admet-1037	127	1	subregions	subregion	NOUN
admet-1037	127	2	of	of	ADP
admet-1037	127	3	the	the	DET
admet-1037	127	4	chemical	chemical	NOUN
admet-1037	127	5	space	space	NOUN
admet-1037	127	6	:	:	PUNCT
admet-1037	127	7	schematic	schematic	ADJ
admet-1037	127	8	representation	representation	NOUN
admet-1037	127	9	.	.	PUNCT
admet-1037	128	1	one	one	NUM
admet-1037	128	2	key	key	ADJ
admet-1037	128	3	aspect	aspect	NOUN
admet-1037	128	4	of	of	ADP
admet-1037	128	5	bro5	bro5	NOUN
admet-1037	128	6	compounds	compound	NOUN
admet-1037	128	7	is	be	AUX
admet-1037	128	8	that	that	SCONJ
admet-1037	128	9	the	the	DET
admet-1037	128	10	larger	large	ADJ
admet-1037	128	11	and	and	CCONJ
admet-1037	128	12	more	more	ADV
admet-1037	128	13	complex	complex	ADJ
admet-1037	128	14	a	a	DET
admet-1037	128	15	structure	structure	NOUN
admet-1037	128	16	is	be	AUX
admet-1037	128	17	,	,	PUNCT
admet-1037	128	18	the	the	DET
admet-1037	128	19	more	more	ADV
admet-1037	128	20	conformation	conformation	NOUN
admet-1037	128	21	-	-	PUNCT
admet-1037	128	22	dependent	dependent	ADJ
admet-1037	128	23	molecular	molecular	ADJ
admet-1037	128	24	properties	property	NOUN
admet-1037	128	25	become	become	VERB
admet-1037	128	26	.	.	PUNCT
admet-1037	129	1	many	many	ADJ
admet-1037	129	2	reports	report	NOUN
admet-1037	129	3	in	in	ADP
admet-1037	129	4	recent	recent	ADJ
admet-1037	129	5	years	year	NOUN
admet-1037	129	6	highlighted	highlight	VERB
admet-1037	129	7	the	the	DET
admet-1037	129	8	importance	importance	NOUN
admet-1037	129	9	of	of	ADP
admet-1037	129	10	considering	consider	VERB
admet-1037	129	11	the	the	DET
admet-1037	129	12	conformational	conformational	ADJ
admet-1037	129	13	landscape	landscape	NOUN
admet-1037	129	14	of	of	ADP
admet-1037	129	15	larger	large	ADJ
admet-1037	129	16	molecules	molecule	NOUN
admet-1037	129	17	when	when	SCONJ
admet-1037	129	18	it	it	PRON
admet-1037	129	19	comes	come	VERB
admet-1037	129	20	to	to	ADP
admet-1037	129	21	defining	define	VERB
admet-1037	129	22	their	their	PRON
admet-1037	129	23	molecular	molecular	ADJ
admet-1037	129	24	properties	property	NOUN
admet-1037	129	25	[	[	X
admet-1037	129	26	24	24	NUM
admet-1037	129	27	]	]	PUNCT
admet-1037	129	28	.	.	PUNCT
admet-1037	130	1	unfortunately	unfortunately	ADV
admet-1037	130	2	,	,	PUNCT
admet-1037	130	3	this	this	PRON
admet-1037	130	4	is	be	AUX
admet-1037	130	5	not	not	PART
admet-1037	130	6	a	a	DET
admet-1037	130	7	minor	minor	ADJ
admet-1037	130	8	task	task	NOUN
admet-1037	130	9	:	:	PUNCT
admet-1037	130	10	with	with	ADP
admet-1037	130	11	the	the	DET
admet-1037	130	12	increase	increase	NOUN
admet-1037	130	13	of	of	ADP
admet-1037	130	14	rotatable	rotatable	ADJ
admet-1037	130	15	bonds	bond	NOUN
admet-1037	130	16	number	number	NOUN
admet-1037	130	17	and	and	CCONJ
admet-1037	130	18	,	,	PUNCT
admet-1037	130	19	consequently	consequently	ADV
admet-1037	130	20	,	,	PUNCT
admet-1037	130	21	the	the	DET
admet-1037	130	22	degrees	degree	NOUN
admet-1037	130	23	of	of	ADP
admet-1037	130	24	freedom	freedom	NOUN
admet-1037	130	25	,	,	PUNCT
admet-1037	130	26	the	the	DET
admet-1037	130	27	number	number	NOUN
admet-1037	130	28	of	of	ADP
admet-1037	130	29	potential	potential	ADJ
admet-1037	130	30	conformers	conformer	NOUN
admet-1037	130	31	increases	increase	VERB
admet-1037	130	32	with	with	ADP
admet-1037	130	33	factorial	factorial	ADJ
admet-1037	130	34	function	function	NOUN
admet-1037	130	35	.	.	PUNCT
admet-1037	131	1	at	at	ADP
admet-1037	131	2	present	present	ADJ
admet-1037	131	3	,	,	PUNCT
admet-1037	131	4	computational	computational	ADJ
admet-1037	131	5	conformational	conformational	ADJ
admet-1037	131	6	sampling	sampling	NOUN
admet-1037	131	7	procedures	procedure	NOUN
admet-1037	131	8	lose	lose	VERB
admet-1037	131	9	accuracy	accuracy	NOUN
admet-1037	131	10	and	and	CCONJ
admet-1037	131	11	consistency	consistency	NOUN
admet-1037	131	12	for	for	ADP
admet-1037	131	13	bro5	bro5	NOUN
admet-1037	131	14	compounds	compound	NOUN
admet-1037	131	15	,	,	PUNCT
admet-1037	131	16	making	make	VERB
admet-1037	131	17	3d	3d	NUM
admet-1037	131	18	descriptors	descriptor	NOUN
admet-1037	131	19	calculation	calculation	NOUN
admet-1037	131	20	still	still	ADV
admet-1037	131	21	challenging	challenge	VERB
admet-1037	131	22	.	.	PUNCT
admet-1037	132	1	therefore	therefore	ADV
admet-1037	132	2	,	,	PUNCT
admet-1037	132	3	due	due	ADP
admet-1037	132	4	to	to	ADP
admet-1037	132	5	the	the	DET
admet-1037	132	6	inherent	inherent	ADJ
admet-1037	132	7	conformational	conformational	ADJ
admet-1037	132	8	limitations	limitation	NOUN
admet-1037	132	9	of	of	ADP
admet-1037	132	10	protacs	protac	NOUN
admet-1037	132	11	®	®	NOUN
admet-1037	132	12	,	,	PUNCT
admet-1037	132	13	we	we	PRON
admet-1037	132	14	selected	select	VERB
admet-1037	132	15	a	a	DET
admet-1037	132	16	pool	pool	NOUN
admet-1037	132	17	of	of	ADP
admet-1037	132	18	2d	2d	NUM
admet-1037	132	19	descriptors	descriptor	NOUN
admet-1037	132	20	that	that	PRON
admet-1037	132	21	provide	provide	VERB
admet-1037	132	22	an	an	DET
admet-1037	132	23	unequivocal	unequivocal	ADJ
admet-1037	132	24	starting	starting	NOUN
admet-1037	132	25	point	point	NOUN
admet-1037	132	26	in	in	ADP
admet-1037	132	27	the	the	DET
admet-1037	132	28	definition	definition	NOUN
admet-1037	132	29	of	of	ADP
admet-1037	132	30	protac	protac	ADJ
admet-1037	132	31	®	®	NOUN
admet-1037	132	32	chemical	chemical	NOUN
admet-1037	132	33	space	space	NOUN
admet-1037	132	34	[	[	X
admet-1037	132	35	17	17	NUM
admet-1037	132	36	]	]	X
admet-1037	132	37	:	:	PUNCT
admet-1037	132	38	mw	mw	X
admet-1037	132	39	as	as	ADP
admet-1037	132	40	a	a	DET
admet-1037	132	41	descriptor	descriptor	NOUN
admet-1037	132	42	of	of	ADP
admet-1037	132	43	molecular	molecular	ADJ
admet-1037	132	44	size	size	NOUN
admet-1037	132	45	;	;	PUNCT
admet-1037	132	46	a	a	DET
admet-1037	132	47	set	set	NOUN
admet-1037	132	48	of	of	ADP
admet-1037	132	49	count	count	NOUN
admet-1037	132	50	descriptors	descriptor	NOUN
admet-1037	132	51	related	relate	VERB
admet-1037	132	52	to	to	ADP
admet-1037	132	53	both	both	CCONJ
admet-1037	132	54	polar	polar	ADJ
admet-1037	132	55	(	(	PUNCT
admet-1037	132	56	nhacc	nhacc	NOUN
admet-1037	132	57	(	(	PUNCT
admet-1037	132	58	also	also	ADV
admet-1037	132	59	hba	hba	NOUN
admet-1037	132	60	)	)	PUNCT
admet-1037	132	61	,	,	PUNCT
admet-1037	132	62	nhdon	nhdon	PROPN
admet-1037	132	63	(	(	PUNCT
admet-1037	132	64	also	also	ADV
admet-1037	132	65	hbd	hbd	NOUN
admet-1037	132	66	)	)	PUNCT
admet-1037	132	67	)	)	PUNCT
admet-1037	132	68	and	and	CCONJ
admet-1037	132	69	nonpolar	nonpolar	ADJ
admet-1037	132	70	(	(	PUNCT
admet-1037	132	71	the	the	DET
admet-1037	132	72	number	number	NOUN
admet-1037	132	73	of	of	ADP
admet-1037	132	74	carbon	carbon	NOUN
admet-1037	132	75	atoms	atom	NOUN
admet-1037	132	76	,	,	PUNCT
admet-1037	132	77	nc	nc	PROPN
admet-1037	132	78	and	and	CCONJ
admet-1037	132	79	the	the	DET
admet-1037	132	80	number	number	NOUN
admet-1037	132	81	of	of	ADP
admet-1037	132	82	aromatic	aromatic	ADJ
admet-1037	132	83	rings	ring	NOUN
admet-1037	132	84	,	,	PUNCT
admet-1037	132	85	nar	nar	NOUN
admet-1037	132	86	)	)	PUNCT
admet-1037	132	87	molecular	molecular	ADJ
admet-1037	132	88	moieties	moiety	NOUN
admet-1037	132	89	;	;	PUNCT
admet-1037	132	90	a	a	DET
admet-1037	132	91	flexibility	flexibility	NOUN
admet-1037	132	92	descriptor	descriptor	NOUN
admet-1037	132	93	(	(	PUNCT
admet-1037	132	94	phi	phi	NOUN
admet-1037	132	95	)	)	PUNCT
admet-1037	133	1	[	[	X
admet-1037	133	2	25	25	NUM
admet-1037	133	3	]	]	PUNCT
admet-1037	133	4	and	and	CCONJ
admet-1037	133	5	tpsa	tpsa	NOUN
admet-1037	133	6	as	as	ADP
admet-1037	133	7	a	a	DET
admet-1037	133	8	polarity	polarity	NOUN
admet-1037	133	9	index	index	NOUN
admet-1037	133	10	.	.	PUNCT
admet-1037	134	1	in	in	ADP
admet-1037	134	2	practice	practice	NOUN
admet-1037	134	3	,	,	PUNCT
admet-1037	134	4	we	we	PRON
admet-1037	134	5	set	set	VERB
admet-1037	134	6	up	up	ADP
admet-1037	134	7	a	a	DET
admet-1037	134	8	pool	pool	NOUN
admet-1037	134	9	of	of	ADP
admet-1037	134	10	seven	seven	NUM
admet-1037	134	11	descriptors	descriptor	NOUN
admet-1037	134	12	,	,	PUNCT
admet-1037	134	13	three	three	NUM
admet-1037	134	14	of	of	ADP
admet-1037	134	15	nonpolar	nonpolar	ADJ
admet-1037	134	16	nature	nature	NOUN
admet-1037	134	17	,	,	PUNCT
admet-1037	134	18	three	three	NUM
admet-1037	134	19	of	of	ADP
admet-1037	134	20	polar	polar	ADJ
admet-1037	134	21	nature	nature	NOUN
admet-1037	134	22	and	and	CCONJ
admet-1037	134	23	one	one	NUM
admet-1037	134	24	flexibility	flexibility	NOUN
admet-1037	134	25	descriptor	descriptor	NOUN
admet-1037	134	26	.	.	PUNCT
admet-1037	135	1	figure	figure	NOUN
admet-1037	135	2	6	6	NUM
admet-1037	135	3	shows	show	VERB
admet-1037	135	4	violin	violin	NOUN
admet-1037	135	5	plots	plot	NOUN
admet-1037	135	6	representing	represent	VERB
admet-1037	135	7	the	the	DET
admet-1037	135	8	seven	seven	NUM
admet-1037	135	9	molecular	molecular	ADJ
admet-1037	135	10	property	property	NOUN
admet-1037	135	11	distribution	distribution	NOUN
admet-1037	135	12	of	of	ADP
admet-1037	135	13	the	the	DET
admet-1037	135	14	2258	2258	NUM
admet-1037	135	15	degraders	degrader	NOUN
admet-1037	135	16	in	in	ADP
admet-1037	135	17	protac	protac	ADJ
admet-1037	135	18	-	-	PUNCT
admet-1037	135	19	db	db	NOUN
admet-1037	135	20	(	(	PUNCT
admet-1037	135	21	average	average	ADJ
admet-1037	135	22	values	value	NOUN
admet-1037	135	23	are	be	AUX
admet-1037	135	24	:	:	PUNCT
admet-1037	135	25	mw=	mw=	NOUN
admet-1037	135	26	972.9	972.9	NUM
admet-1037	135	27	da	da	NOUN
admet-1037	135	28	,	,	PUNCT
admet-1037	135	29	nc=	nc=	NOUN
admet-1037	135	30	49.5	49.5	NUM
admet-1037	135	31	,	,	PUNCT
admet-1037	135	32	nar=	nar=	PROPN
admet-1037	135	33	4.5	4.5	NUM
admet-1037	135	34	,	,	PUNCT
admet-1037	135	35	phi=	phi=	PROPN
admet-1037	135	36	17.3	17.3	NUM
admet-1037	135	37	,	,	PUNCT
admet-1037	135	38	nhdon=	nhdon=	NUM
admet-1037	135	39	4.5	4.5	NUM
admet-1037	135	40	,	,	PUNCT
admet-1037	135	41	nhacc=	nhacc=	PROPN
admet-1037	135	42	17.7	17.7	NUM
admet-1037	135	43	and	and	CCONJ
admet-1037	135	44	tpsa=	tpsa=	NUM
admet-1037	135	45	240	240	NUM
admet-1037	135	46	å	å	PROPN
admet-1037	135	47	2	2	NUM
admet-1037	135	48	)	)	PUNCT
admet-1037	135	49	(	(	PUNCT
admet-1037	135	50	table	table	NOUN
admet-1037	135	51	s1	s1	NOUN
admet-1037	135	52	)	)	PUNCT
admet-1037	135	53	.	.	PUNCT
admet-1037	136	1	the	the	DET
admet-1037	136	2	average	average	NOUN
admet-1037	136	3	of	of	ADP
admet-1037	136	4	the	the	DET
admet-1037	136	5	7	7	NUM
admet-1037	136	6	calculated	calculate	VERB
admet-1037	136	7	descriptors	descriptor	NOUN
admet-1037	136	8	for	for	ADP
admet-1037	136	9	degraders	degrader	NOUN
admet-1037	136	10	were	be	AUX
admet-1037	136	11	compared	compare	VERB
admet-1037	136	12	to	to	ADP
admet-1037	136	13	those	those	PRON
admet-1037	136	14	previously	previously	ADV
admet-1037	136	15	calculated	calculate	VERB
admet-1037	136	16	for	for	ADP
admet-1037	136	17	50	50	NUM
admet-1037	136	18	orally	orally	ADV
admet-1037	136	19	approved	approve	VERB
admet-1037	136	20	bro5	bro5	NOUN
admet-1037	136	21	drugs	drug	NOUN
admet-1037	136	22	[	[	X
admet-1037	136	23	17	17	NUM
admet-1037	136	24	]	]	X
admet-1037	136	25	(	(	PUNCT
admet-1037	136	26	mw=	mw=	NOUN
admet-1037	136	27	765	765	NUM
admet-1037	136	28	da	da	NOUN
admet-1037	136	29	,	,	PUNCT
admet-1037	136	30	nc=	nc=	NOUN
admet-1037	136	31	39	39	NUM
admet-1037	136	32	,	,	PUNCT
admet-1037	136	33	nar=	nar=	PROPN
admet-1037	136	34	2	2	NUM
admet-1037	136	35	,	,	PUNCT
admet-1037	136	36	phi=	phi=	PROPN
admet-1037	136	37	14	14	NUM
admet-1037	136	38	,	,	PUNCT
admet-1037	136	39	tpsa=	tpsa=	NUM
admet-1037	136	40	177	177	NUM
admet-1037	136	41	å2	å2	NOUN
admet-1037	136	42	,	,	PUNCT
admet-1037	136	43	nhdon=	nhdon=	NUM
admet-1037	136	44	3	3	NUM
admet-1037	136	45	and	and	CCONJ
admet-1037	136	46	nhacc=	nhacc=	NUM
admet-1037	136	47	13	13	NUM
admet-1037	136	48	)	)	PUNCT
admet-1037	136	49	,	,	PUNCT
admet-1037	136	50	introduced	introduce	VERB
admet-1037	136	51	by	by	ADP
admet-1037	136	52	kihlberg	kihlberg	PROPN
admet-1037	136	53	et	et	PROPN
admet-1037	136	54	al	al	PROPN
admet-1037	136	55	.	.	PUNCT
admet-1037	137	1	[	[	X
admet-1037	137	2	18	18	NUM
admet-1037	137	3	]	]	PUNCT
admet-1037	137	4	.	.	PUNCT
admet-1037	138	1	results	result	NOUN
admet-1037	138	2	,	,	PUNCT
admet-1037	138	3	presented	present	VERB
admet-1037	138	4	in	in	ADP
admet-1037	138	5	a	a	DET
admet-1037	138	6	radar	radar	NOUN
admet-1037	138	7	plot	plot	NOUN
admet-1037	138	8	,	,	PUNCT
admet-1037	138	9	confirm	confirm	VERB
admet-1037	138	10	that	that	SCONJ
admet-1037	138	11	protacs	protac	NOUN
admet-1037	138	12	®	®	NOUN
admet-1037	138	13	cover	cover	VERB
admet-1037	138	14	a	a	DET
admet-1037	138	15	wider	wide	ADJ
admet-1037	138	16	property	property	NOUN
admet-1037	138	17	range	range	NOUN
admet-1037	138	18	,	,	PUNCT
admet-1037	138	19	being	be	AUX
admet-1037	138	20	the	the	DET
admet-1037	138	21	degrader´s	degrader´s	NOUN
admet-1037	138	22	nar	nar	NOUN
admet-1037	138	23	more	more	ADJ
admet-1037	138	24	than	than	ADP
admet-1037	138	25	twice	twice	DET
admet-1037	138	26	the	the	DET
admet-1037	138	27	value	value	NOUN
admet-1037	138	28	for	for	ADP
admet-1037	138	29	orally	orally	ADV
admet-1037	138	30	approved	approve	VERB
admet-1037	138	31	bro5	bro5	NOUN
admet-1037	138	32	drugs	drug	NOUN
admet-1037	138	33	(	(	PUNCT
admet-1037	138	34	fig	fig	NOUN
admet-1037	138	35	.	.	PUNCT
admet-1037	139	1	7a	7a	NUM
admet-1037	139	2	)	)	PUNCT
admet-1037	139	3	.	.	PUNCT
admet-1037	140	1	nevertheless	nevertheless	ADV
admet-1037	140	2	,	,	PUNCT
admet-1037	140	3	it	it	PRON
admet-1037	140	4	must	must	AUX
admet-1037	140	5	be	be	AUX
admet-1037	140	6	mentioned	mention	VERB
admet-1037	140	7	that	that	SCONJ
admet-1037	140	8	some	some	PRON
admet-1037	140	9	of	of	ADP
admet-1037	140	10	the	the	DET
admet-1037	140	11	represented	represent	VERB
admet-1037	140	12	protacs	protac	NOUN
admet-1037	140	13	®	®	NOUN
admet-1037	140	14	were	be	AUX
admet-1037	140	15	designed	design	VERB
admet-1037	140	16	as	as	ADP
admet-1037	140	17	scientific	scientific	ADJ
admet-1037	140	18	tools	tool	NOUN
admet-1037	140	19	,	,	PUNCT
admet-1037	140	20	unintended	unintended	ADJ
admet-1037	140	21	to	to	PART
admet-1037	140	22	be	be	AUX
admet-1037	140	23	pharmaceutical	pharmaceutical	ADJ
admet-1037	140	24	candidates	candidate	NOUN
admet-1037	140	25	with	with	ADP
admet-1037	140	26	optimal	optimal	ADJ
admet-1037	140	27	dmpk	dmpk	NOUN
admet-1037	140	28	properties	property	NOUN
admet-1037	140	29	.	.	PUNCT
admet-1037	141	1	moreover	moreover	ADV
admet-1037	141	2	,	,	PUNCT
admet-1037	141	3	to	to	PART
admet-1037	141	4	better	well	ADV
admet-1037	141	5	visualize	visualize	VERB
admet-1037	141	6	the	the	DET
admet-1037	141	7	property	property	NOUN
admet-1037	141	8	distribution	distribution	NOUN
admet-1037	141	9	we	we	PRON
admet-1037	141	10	defined	define	VERB
admet-1037	141	11	a	a	DET
admet-1037	141	12	chemical	chemical	NOUN
admet-1037	141	13	space	space	NOUN
admet-1037	141	14	by	by	ADP
admet-1037	141	15	including	include	VERB
admet-1037	141	16	three	three	NUM
admet-1037	141	17	representative	representative	ADJ
admet-1037	141	18	descriptors	descriptor	NOUN
admet-1037	141	19	:	:	PUNCT
admet-1037	141	20	nc	nc	PROPN
admet-1037	141	21	(	(	PUNCT
admet-1037	141	22	nonpolar	nonpolar	NOUN
admet-1037	141	23	)	)	PUNCT
admet-1037	141	24	,	,	PUNCT
admet-1037	141	25	tpsa	tpsa	NOUN
admet-1037	141	26	(	(	PUNCT
admet-1037	141	27	polar	polar	ADJ
admet-1037	141	28	)	)	PUNCT
admet-1037	141	29	and	and	CCONJ
admet-1037	141	30	phi	phi	NOUN
admet-1037	141	31	(	(	PUNCT
admet-1037	141	32	flexibility	flexibility	NOUN
admet-1037	141	33	)	)	PUNCT
admet-1037	141	34	(	(	PUNCT
admet-1037	141	35	fig	fig	NOUN
admet-1037	141	36	.	.	PUNCT
admet-1037	142	1	7b	7b	NOUN
admet-1037	142	2	)	)	PUNCT
admet-1037	142	3	.	.	PUNCT
admet-1037	143	1	admet	admet	PROPN
admet-1037	143	2	&	&	CCONJ
admet-1037	143	3	dmpk	dmpk	PROPN
admet-1037	143	4	9(4	9(4	PROPN
admet-1037	143	5	)	)	PUNCT
admet-1037	143	6	(	(	PUNCT
admet-1037	143	7	2021	2021	NUM
admet-1037	143	8	)	)	PUNCT
admet-1037	143	9	243	243	NUM
admet-1037	143	10	-	-	SYM
admet-1037	143	11	254	254	NUM
admet-1037	143	12	are	be	AUX
admet-1037	143	13	we	we	PRON
admet-1037	143	14	ready	ready	ADJ
admet-1037	143	15	to	to	PART
admet-1037	143	16	design	design	VERB
admet-1037	143	17	oral	oral	ADJ
admet-1037	143	18	protacs	protacs	PROPN
admet-1037	143	19	®	®	NOUN
admet-1037	143	20	?	?	PUNCT
admet-1037	144	1	doi	doi	PROPN
admet-1037	144	2	:	:	PUNCT
admet-1037	144	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	NUM
admet-1037	144	4	249	249	NUM
admet-1037	144	5	mw	mw	NOUN
admet-1037	144	6	0	0	NUM
admet-1037	144	7	500	500	NUM
admet-1037	144	8	1000	1000	NUM
admet-1037	144	9	1500	1500	NUM
admet-1037	144	10	2000	2000	NUM
admet-1037	144	11	nc	nc	X
admet-1037	144	12	0	0	NUM
admet-1037	144	13	50	50	NUM
admet-1037	144	14	100	100	NUM
admet-1037	144	15	nar	nar	NOUN
admet-1037	144	16	0	0	NUM
admet-1037	144	17	2	2	NUM
admet-1037	144	18	4	4	NUM
admet-1037	144	19	6	6	NUM
admet-1037	144	20	8	8	NUM
admet-1037	144	21	10	10	NUM
admet-1037	144	22	phi	phi	NOUN
admet-1037	144	23	0	0	NUM
admet-1037	144	24	10	10	NUM
admet-1037	144	25	20	20	NUM
admet-1037	144	26	30	30	NUM
admet-1037	144	27	40	40	NUM
admet-1037	144	28	50	50	NUM
admet-1037	144	29	tpsa	tpsa	NOUN
admet-1037	144	30	0	0	NUM
admet-1037	144	31	100	100	NUM
admet-1037	144	32	200	200	NUM
admet-1037	144	33	300	300	NUM
admet-1037	144	34	400	400	NUM
admet-1037	144	35	500	500	NUM
admet-1037	144	36	nhdon	nhdon	PROPN
admet-1037	144	37	nhacc	nhacc	NOUN
admet-1037	144	38	0	0	NUM
admet-1037	144	39	10	10	NUM
admet-1037	144	40	20	20	NUM
admet-1037	144	41	30	30	NUM
admet-1037	144	42	40	40	NUM
admet-1037	144	43	figure	figure	NOUN
admet-1037	144	44	6	6	NUM
admet-1037	144	45	.	.	PUNCT
admet-1037	144	46	violin	violin	NOUN
admet-1037	144	47	plots	plot	NOUN
admet-1037	144	48	representing	represent	VERB
admet-1037	144	49	the	the	DET
admet-1037	144	50	molecular	molecular	ADJ
admet-1037	144	51	property	property	NOUN
admet-1037	144	52	distribution	distribution	NOUN
admet-1037	144	53	of	of	ADP
admet-1037	144	54	the	the	DET
admet-1037	144	55	2258	2258	NUM
admet-1037	144	56	degraders	degrader	NOUN
admet-1037	144	57	in	in	ADP
admet-1037	144	58	protac	protac	ADJ
admet-1037	144	59	-	-	PUNCT
admet-1037	144	60	db	db	NOUN
admet-1037	144	61	;	;	PUNCT
admet-1037	144	62	molecular	molecular	ADJ
admet-1037	144	63	weight	weight	NOUN
admet-1037	144	64	(	(	PUNCT
admet-1037	144	65	mw	mw	X
admet-1037	144	66	,	,	PUNCT
admet-1037	144	67	da	da	ADJ
admet-1037	144	68	)	)	PUNCT
admet-1037	144	69	and	and	CCONJ
admet-1037	144	70	number	number	NOUN
admet-1037	144	71	of	of	ADP
admet-1037	144	72	carbons	carbon	NOUN
admet-1037	144	73	(	(	PUNCT
admet-1037	144	74	nc	nc	NOUN
admet-1037	144	75	)	)	PUNCT
admet-1037	144	76	(	(	PUNCT
admet-1037	144	77	green	green	NOUN
admet-1037	144	78	)	)	PUNCT
admet-1037	144	79	,	,	PUNCT
admet-1037	144	80	number	number	NOUN
admet-1037	144	81	of	of	ADP
admet-1037	144	82	aromatic	aromatic	ADJ
admet-1037	144	83	rings	ring	NOUN
admet-1037	144	84	(	(	PUNCT
admet-1037	144	85	nar)(yellow	nar)(yellow	PROPN
admet-1037	144	86	)	)	PUNCT
admet-1037	144	87	,	,	PUNCT
admet-1037	144	88	kier	kier	PROPN
admet-1037	144	89	's	's	PART
admet-1037	144	90	flexibility	flexibility	NOUN
admet-1037	144	91	index	index	NOUN
admet-1037	144	92	(	(	PUNCT
admet-1037	144	93	phi	phi	NOUN
admet-1037	144	94	)	)	PUNCT
admet-1037	144	95	(	(	PUNCT
admet-1037	144	96	purple	purple	NOUN
admet-1037	144	97	)	)	PUNCT
admet-1037	144	98	,	,	PUNCT
admet-1037	144	99	topological	topological	ADJ
admet-1037	144	100	polar	polar	ADJ
admet-1037	144	101	surface	surface	NOUN
admet-1037	144	102	area	area	NOUN
admet-1037	144	103	(	(	PUNCT
admet-1037	144	104	tpsa	tpsa	PROPN
admet-1037	144	105	,	,	PUNCT
admet-1037	144	106	å	å	PROPN
admet-1037	144	107	2	2	NUM
admet-1037	144	108	)	)	PUNCT
admet-1037	144	109	(	(	PUNCT
admet-1037	144	110	light	light	NOUN
admet-1037	144	111	blue	blue	NOUN
admet-1037	144	112	)	)	PUNCT
admet-1037	144	113	and	and	CCONJ
admet-1037	144	114	number	number	NOUN
admet-1037	144	115	of	of	ADP
admet-1037	144	116	hydrogen	hydrogen	NOUN
admet-1037	144	117	bond	bond	NOUN
admet-1037	144	118	acceptors	acceptor	NOUN
admet-1037	144	119	and	and	CCONJ
admet-1037	144	120	donors	donor	NOUN
admet-1037	144	121	(	(	PUNCT
admet-1037	144	122	nhdon	nhdon	NOUN
admet-1037	144	123	and	and	CCONJ
admet-1037	144	124	nhacc	nhacc	NOUN
admet-1037	144	125	)	)	PUNCT
admet-1037	144	126	(	(	PUNCT
admet-1037	144	127	dark	dark	ADJ
admet-1037	144	128	red	red	ADJ
admet-1037	144	129	and	and	CCONJ
admet-1037	144	130	blue	blue	ADJ
admet-1037	144	131	,	,	PUNCT
admet-1037	144	132	respectively	respectively	ADV
admet-1037	144	133	)	)	PUNCT
admet-1037	144	134	.	.	PUNCT
admet-1037	145	1	the	the	DET
admet-1037	145	2	50th	50th	ADJ
admet-1037	145	3	percentiles	percentile	NOUN
admet-1037	145	4	or	or	CCONJ
admet-1037	145	5	medians	median	NOUN
admet-1037	145	6	are	be	AUX
admet-1037	145	7	represented	represent	VERB
admet-1037	145	8	as	as	ADP
admet-1037	145	9	solid	solid	ADJ
admet-1037	145	10	horizontal	horizontal	ADJ
admet-1037	145	11	bars	bar	NOUN
admet-1037	145	12	and	and	CCONJ
admet-1037	145	13	the	the	DET
admet-1037	145	14	25th	25th	NOUN
admet-1037	145	15	and	and	CCONJ
admet-1037	145	16	75	75	NUM
admet-1037	145	17	th	th	NUM
admet-1037	145	18	percentiles	percentile	NOUN
admet-1037	145	19	as	as	ADP
admet-1037	145	20	dashed	dash	VERB
admet-1037	145	21	lines	line	NOUN
admet-1037	145	22	.	.	PUNCT
admet-1037	146	1	the	the	DET
admet-1037	146	2	picture	picture	NOUN
admet-1037	146	3	emerging	emerge	VERB
admet-1037	146	4	is	be	AUX
admet-1037	146	5	that	that	SCONJ
admet-1037	146	6	the	the	DET
admet-1037	146	7	protac	protac	ADJ
admet-1037	146	8	®	®	NOUN
admet-1037	146	9	chemical	chemical	NOUN
admet-1037	146	10	space	space	NOUN
admet-1037	146	11	is	be	AUX
admet-1037	146	12	adjacent	adjacent	ADJ
admet-1037	146	13	and	and	CCONJ
admet-1037	146	14	only	only	ADV
admet-1037	146	15	partially	partially	ADV
admet-1037	146	16	stackable	stackable	ADJ
admet-1037	146	17	to	to	ADP
admet-1037	146	18	the	the	DET
admet-1037	146	19	region	region	NOUN
admet-1037	146	20	occupied	occupy	VERB
admet-1037	146	21	by	by	ADP
admet-1037	146	22	oral	oral	ADJ
admet-1037	146	23	bro5	bro5	NOUN
admet-1037	146	24	drugs	drug	NOUN
admet-1037	146	25	:	:	PUNCT
admet-1037	146	26	the	the	DET
admet-1037	146	27	majority	majority	NOUN
admet-1037	146	28	of	of	ADP
admet-1037	146	29	protacs	protac	NOUN
admet-1037	146	30	®	®	NOUN
admet-1037	146	31	have	have	VERB
admet-1037	146	32	a	a	DET
admet-1037	146	33	higher	high	ADJ
admet-1037	146	34	number	number	NOUN
admet-1037	146	35	of	of	ADP
admet-1037	146	36	carbon	carbon	NOUN
admet-1037	146	37	atoms	atom	NOUN
admet-1037	146	38	than	than	ADP
admet-1037	146	39	the	the	DET
admet-1037	146	40	analysed	analyse	VERB
admet-1037	146	41	bro5	bro5	NOUN
admet-1037	146	42	compounds	compound	NOUN
admet-1037	146	43	.	.	PUNCT
admet-1037	147	1	this	this	PRON
admet-1037	147	2	is	be	AUX
admet-1037	147	3	a	a	DET
admet-1037	147	4	bona	bona	ADJ
admet-1037	147	5	fide	fide	ADJ
admet-1037	147	6	indicator	indicator	NOUN
admet-1037	147	7	of	of	ADP
admet-1037	147	8	larger	large	ADJ
admet-1037	147	9	structures	structure	NOUN
admet-1037	147	10	.	.	PUNCT
admet-1037	148	1	topological	topological	ADJ
admet-1037	148	2	polar	polar	ADJ
admet-1037	148	3	surface	surface	NOUN
admet-1037	148	4	area	area	NOUN
admet-1037	148	5	is	be	AUX
admet-1037	148	6	also	also	ADV
admet-1037	148	7	higher	high	ADJ
admet-1037	148	8	.	.	PUNCT
admet-1037	149	1	this	this	DET
admet-1037	149	2	aspect	aspect	NOUN
admet-1037	149	3	is	be	AUX
admet-1037	149	4	of	of	ADP
admet-1037	149	5	greater	great	ADJ
admet-1037	149	6	interest	interest	NOUN
admet-1037	149	7	since	since	SCONJ
admet-1037	149	8	a	a	DET
admet-1037	149	9	greater	great	ADJ
admet-1037	149	10	polar	polar	ADJ
admet-1037	149	11	surface	surface	NOUN
admet-1037	149	12	area	area	NOUN
admet-1037	149	13	is	be	AUX
admet-1037	149	14	often	often	ADV
admet-1037	149	15	associated	associate	VERB
admet-1037	149	16	with	with	ADP
admet-1037	149	17	lower	low	ADJ
admet-1037	149	18	permeability	permeability	NOUN
admet-1037	149	19	.	.	PUNCT
admet-1037	150	1	nevertheless	nevertheless	ADV
admet-1037	150	2	,	,	PUNCT
admet-1037	150	3	here	here	ADV
admet-1037	150	4	we	we	PRON
admet-1037	150	5	are	be	AUX
admet-1037	150	6	considering	consider	VERB
admet-1037	150	7	fragment	fragment	NOUN
admet-1037	150	8	-	-	PUNCT
admet-1037	150	9	calculated	calculate	VERB
admet-1037	150	10	(	(	PUNCT
admet-1037	150	11	topological	topological	ADJ
admet-1037	150	12	)	)	PUNCT
admet-1037	150	13	2d	2d	PROPN
admet-1037	150	14	surface	surface	NOUN
admet-1037	150	15	area	area	NOUN
admet-1037	150	16	which	which	PRON
admet-1037	150	17	does	do	AUX
admet-1037	150	18	not	not	PART
admet-1037	150	19	include	include	VERB
admet-1037	150	20	3d	3d	NUM
admet-1037	150	21	information	information	NOUN
admet-1037	150	22	.	.	PUNCT
admet-1037	151	1	thus	thus	ADV
admet-1037	151	2	,	,	PUNCT
admet-1037	151	3	this	this	DET
admet-1037	151	4	aspect	aspect	NOUN
admet-1037	151	5	must	must	AUX
admet-1037	151	6	be	be	AUX
admet-1037	151	7	carefully	carefully	ADV
admet-1037	151	8	considered	consider	VERB
admet-1037	151	9	.	.	PUNCT
admet-1037	152	1	indeed	indeed	ADV
admet-1037	152	2	,	,	PUNCT
admet-1037	152	3	protacs	protacs	PROPN
admet-1037	152	4	®	®	NOUN
admet-1037	152	5	present	present	ADJ
admet-1037	152	6	in	in	ADP
admet-1037	152	7	protac	protac	ADJ
admet-1037	152	8	-	-	PUNCT
admet-1037	152	9	db	db	NOUN
admet-1037	152	10	show	show	NOUN
admet-1037	152	11	also	also	ADV
admet-1037	152	12	a	a	DET
admet-1037	152	13	higher	high	ADJ
admet-1037	152	14	kier	kier	PROPN
admet-1037	152	15	’s	’s	PART
admet-1037	152	16	flexibility	flexibility	NOUN
admet-1037	152	17	index	index	NOUN
admet-1037	152	18	(	(	PUNCT
admet-1037	152	19	phi	phi	NOUN
admet-1037	152	20	)	)	PUNCT
admet-1037	152	21	,	,	PUNCT
admet-1037	152	22	suggesting	suggest	VERB
admet-1037	152	23	that	that	SCONJ
admet-1037	152	24	the	the	DET
admet-1037	152	25	average	average	ADJ
admet-1037	152	26	increase	increase	NOUN
admet-1037	152	27	in	in	ADP
admet-1037	152	28	polar	polar	ADJ
admet-1037	152	29	fragments	fragment	NOUN
admet-1037	152	30	,	,	PUNCT
admet-1037	152	31	might	might	AUX
admet-1037	152	32	be	be	AUX
admet-1037	152	33	compensated	compensate	VERB
admet-1037	152	34	with	with	ADP
admet-1037	152	35	higher	high	ADJ
admet-1037	152	36	flexibility	flexibility	NOUN
admet-1037	152	37	and	and	CCONJ
admet-1037	152	38	polar	polar	ADJ
admet-1037	152	39	moieties	moiety	NOUN
admet-1037	152	40	shielding	shielding	NOUN
admet-1037	152	41	.	.	PUNCT
admet-1037	153	1	this	this	DET
admet-1037	153	2	fact	fact	NOUN
admet-1037	153	3	has	have	AUX
admet-1037	153	4	already	already	ADV
admet-1037	153	5	been	be	AUX
admet-1037	153	6	extensively	extensively	ADV
admet-1037	153	7	reported	report	VERB
admet-1037	153	8	in	in	ADP
admet-1037	153	9	the	the	DET
admet-1037	153	10	bro5	bro5	NOUN
admet-1037	153	11	chemical	chemical	NOUN
admet-1037	153	12	space	space	NOUN
admet-1037	153	13	[	[	X
admet-1037	153	14	26,27	26,27	NUM
admet-1037	153	15	]	]	PUNCT
admet-1037	153	16	.	.	PUNCT
admet-1037	154	1	finally	finally	ADV
admet-1037	154	2	,	,	PUNCT
admet-1037	154	3	it	it	PRON
admet-1037	154	4	should	should	AUX
admet-1037	154	5	be	be	AUX
admet-1037	154	6	recalled	recall	VERB
admet-1037	154	7	that	that	SCONJ
admet-1037	154	8	protac	protac	ADJ
admet-1037	154	9	-	-	PUNCT
admet-1037	154	10	db	db	NOUN
admet-1037	154	11	does	do	AUX
admet-1037	154	12	not	not	PART
admet-1037	154	13	include	include	VERB
admet-1037	154	14	most	most	ADJ
admet-1037	154	15	of	of	ADP
admet-1037	154	16	the	the	DET
admet-1037	154	17	proprietary	proprietary	ADJ
admet-1037	154	18	compounds	compound	NOUN
admet-1037	154	19	which	which	PRON
admet-1037	154	20	might	might	AUX
admet-1037	154	21	occupy	occupy	VERB
admet-1037	154	22	further	further	ADJ
admet-1037	154	23	regions	region	NOUN
admet-1037	154	24	in	in	ADP
admet-1037	154	25	the	the	DET
admet-1037	154	26	chemical	chemical	NOUN
admet-1037	154	27	space	space	NOUN
admet-1037	154	28	.	.	PUNCT
admet-1037	155	1	subregions	subregion	NOUN
admet-1037	155	2	in	in	ADP
admet-1037	155	3	the	the	DET
admet-1037	155	4	protacs	protac	NOUN
admet-1037	155	5	®	®	NOUN
admet-1037	155	6	chemical	chemical	ADJ
admet-1037	155	7	space	space	NOUN
admet-1037	155	8	populated	populate	VERB
admet-1037	155	9	with	with	ADP
admet-1037	155	10	potential	potential	ADJ
admet-1037	155	11	oral	oral	ADJ
admet-1037	155	12	drugs	drug	NOUN
admet-1037	155	13	.	.	PUNCT
admet-1037	156	1	a	a	DET
admet-1037	156	2	protac	protac	ADJ
admet-1037	156	3	®	®	NOUN
admet-1037	156	4	chemical	chemical	NOUN
admet-1037	156	5	space	space	NOUN
admet-1037	156	6	represents	represent	VERB
admet-1037	156	7	an	an	DET
admet-1037	156	8	extraordinary	extraordinary	ADJ
admet-1037	156	9	tool	tool	NOUN
admet-1037	156	10	to	to	PART
admet-1037	156	11	identify	identify	VERB
admet-1037	156	12	groups	group	NOUN
admet-1037	156	13	of	of	ADP
admet-1037	156	14	degraders	degrader	NOUN
admet-1037	156	15	or	or	CCONJ
admet-1037	156	16	clusters	cluster	NOUN
admet-1037	156	17	sharing	share	VERB
admet-1037	156	18	similar	similar	ADJ
admet-1037	156	19	chemical	chemical	NOUN
admet-1037	156	20	or	or	CCONJ
admet-1037	156	21	in	in	ADP
admet-1037	156	22	vitro	vitro	X
admet-1037	156	23	adme	adme	NOUN
admet-1037	156	24	properties	property	NOUN
admet-1037	156	25	.	.	PUNCT
admet-1037	157	1	in	in	ADP
admet-1037	157	2	particular	particular	ADJ
admet-1037	157	3	,	,	PUNCT
admet-1037	157	4	the	the	DET
admet-1037	157	5	potential	potential	NOUN
admet-1037	157	6	of	of	ADP
admet-1037	157	7	degraders	degrader	NOUN
admet-1037	157	8	to	to	PART
admet-1037	157	9	become	become	VERB
admet-1037	157	10	oral	oral	ADJ
admet-1037	157	11	drugs	drug	NOUN
admet-1037	157	12	could	could	AUX
admet-1037	157	13	be	be	AUX
admet-1037	157	14	defined	define	VERB
admet-1037	157	15	by	by	ADP
admet-1037	157	16	bioavailability	bioavailability	NOUN
admet-1037	157	17	and	and	CCONJ
admet-1037	157	18	permeability	permeability	NOUN
admet-1037	157	19	,	,	PUNCT
admet-1037	157	20	among	among	ADP
admet-1037	157	21	others	other	NOUN
admet-1037	157	22	.	.	PUNCT
admet-1037	158	1	bioavailability	bioavailability	NOUN
admet-1037	158	2	(	(	PUNCT
admet-1037	158	3	f%	f%	NOUN
admet-1037	158	4	)	)	PUNCT
admet-1037	158	5	is	be	AUX
admet-1037	158	6	defined	define	VERB
admet-1037	158	7	as	as	ADP
admet-1037	158	8	the	the	DET
admet-1037	158	9	fraction	fraction	NOUN
admet-1037	158	10	of	of	ADP
admet-1037	158	11	drug	drug	NOUN
admet-1037	158	12	that	that	PRON
admet-1037	158	13	reaches	reach	VERB
admet-1037	158	14	systemic	systemic	ADJ
admet-1037	158	15	circulation	circulation	NOUN
admet-1037	158	16	and	and	CCONJ
admet-1037	158	17	thus	thus	ADV
admet-1037	158	18	needs	need	VERB
admet-1037	158	19	an	an	DET
admet-1037	158	20	in	in	ADP
admet-1037	158	21	vivo	vivo	ADJ
admet-1037	158	22	experimental	experimental	ADJ
admet-1037	158	23	determination	determination	NOUN
admet-1037	158	24	.	.	PUNCT
admet-1037	159	1	consequently	consequently	ADV
admet-1037	159	2	,	,	PUNCT
admet-1037	159	3	the	the	DET
admet-1037	159	4	recently	recently	ADV
admet-1037	159	5	disclosed	disclose	VERB
admet-1037	159	6	orally	orally	ADV
admet-1037	159	7	bioavailable	bioavailable	ADJ
admet-1037	159	8	degraders	degrader	NOUN
admet-1037	159	9	arv-110	arv-110	ADJ
admet-1037	159	10	and	and	CCONJ
admet-1037	159	11	arv-471	arv-471	NOUN
admet-1037	159	12	(	(	PUNCT
admet-1037	159	13	fig	fig	NOUN
admet-1037	159	14	.	.	PUNCT
admet-1037	160	1	8)	8)	NUM
admet-1037	160	2	,	,	PUNCT
admet-1037	160	3	were	be	AUX
admet-1037	160	4	introduced	introduce	VERB
admet-1037	160	5	into	into	ADP
admet-1037	160	6	the	the	DET
admet-1037	160	7	chemical	chemical	NOUN
admet-1037	160	8	space	space	NOUN
admet-1037	160	9	defined	define	VERB
admet-1037	160	10	above	above	ADV
admet-1037	160	11	.	.	PUNCT
admet-1037	161	1	both	both	DET
admet-1037	161	2	structures	structure	NOUN
admet-1037	161	3	are	be	AUX
admet-1037	161	4	located	locate	VERB
admet-1037	161	5	in	in	ADP
admet-1037	161	6	the	the	DET
admet-1037	161	7	boundaries	boundary	NOUN
admet-1037	161	8	of	of	ADP
admet-1037	161	9	the	the	DET
admet-1037	161	10	chemical	chemical	NOUN
admet-1037	161	11	space	space	NOUN
admet-1037	161	12	.	.	PUNCT
admet-1037	162	1	regarding	regard	VERB
admet-1037	162	2	their	their	PRON
admet-1037	162	3	molecular	molecular	ADJ
admet-1037	162	4	size	size	NOUN
admet-1037	162	5	,	,	PUNCT
admet-1037	162	6	their	their	PRON
admet-1037	162	7	structure	structure	NOUN
admet-1037	162	8	contains	contain	VERB
admet-1037	162	9	41	41	NUM
admet-1037	162	10	and	and	CCONJ
admet-1037	162	11	45	45	NUM
admet-1037	162	12	carbons	carbon	NOUN
admet-1037	162	13	respectively	respectively	ADV
admet-1037	162	14	,	,	PUNCT
admet-1037	162	15	being	be	AUX
admet-1037	162	16	placed	place	VERB
admet-1037	162	17	on	on	ADP
admet-1037	162	18	the	the	DET
admet-1037	162	19	first	first	ADJ
admet-1037	162	20	quartile	quartile	NOUN
admet-1037	162	21	with	with	ADP
admet-1037	162	22	respect	respect	NOUN
admet-1037	162	23	to	to	ADP
admet-1037	162	24	the	the	DET
admet-1037	162	25	protac	protac	ADJ
admet-1037	162	26	-	-	PUNCT
admet-1037	162	27	db	db	NOUN
admet-1037	162	28	average	average	NOUN
admet-1037	162	29	(	(	PUNCT
admet-1037	162	30	nc=	nc=	NOUN
admet-1037	162	31	49.5	49.5	NUM
admet-1037	162	32	)	)	PUNCT
admet-1037	162	33	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	PUNCT
admet-1037	163	1	g.	g.	PROPN
admet-1037	163	2	ermondi	ermondi	PROPN
admet-1037	163	3	et	et	PROPN
admet-1037	163	4	al	al	PROPN
admet-1037	163	5	.	.	PROPN
admet-1037	163	6	admet	admet	PROPN
admet-1037	163	7	&	&	CCONJ
admet-1037	163	8	dmpk	dmpk	PROPN
admet-1037	163	9	9(4	9(4	PROPN
admet-1037	163	10	)	)	PUNCT
admet-1037	163	11	(	(	PUNCT
admet-1037	163	12	2021	2021	NUM
admet-1037	163	13	)	)	PUNCT
admet-1037	163	14	243	243	NUM
admet-1037	163	15	-	-	SYM
admet-1037	163	16	254	254	NUM
admet-1037	163	17	250	250	NUM
admet-1037	163	18	(	(	PUNCT
admet-1037	163	19	fig	fig	NOUN
admet-1037	163	20	.	.	PUNCT
admet-1037	163	21	6	6	NUM
admet-1037	163	22	)	)	PUNCT
admet-1037	163	23	.	.	PUNCT
admet-1037	164	1	moreover	moreover	ADV
admet-1037	164	2	,	,	PUNCT
admet-1037	164	3	their	their	PRON
admet-1037	164	4	significantly	significantly	ADV
admet-1037	164	5	low	low	ADJ
admet-1037	164	6	phi	phi	NOUN
admet-1037	164	7	index	index	NOUN
admet-1037	164	8	(	(	PUNCT
admet-1037	164	9	12	12	NUM
admet-1037	164	10	and	and	CCONJ
admet-1037	164	11	10	10	NUM
admet-1037	164	12	respectively	respectively	ADV
admet-1037	164	13	)	)	PUNCT
admet-1037	164	14	compared	compare	VERB
admet-1037	164	15	to	to	ADP
admet-1037	164	16	the	the	DET
admet-1037	164	17	protac	protac	ADJ
admet-1037	164	18	-	-	PUNCT
admet-1037	164	19	db	db	NOUN
admet-1037	164	20	average	average	NOUN
admet-1037	164	21	(	(	PUNCT
admet-1037	164	22	phi=	phi=	PROPN
admet-1037	164	23	17.3	17.3	NUM
admet-1037	164	24	)	)	PUNCT
admet-1037	164	25	places	place	NOUN
admet-1037	164	26	both	both	DET
admet-1037	164	27	degraders	degrader	NOUN
admet-1037	164	28	in	in	ADP
admet-1037	164	29	the	the	DET
admet-1037	164	30	first	first	ADJ
admet-1037	164	31	quartile	quartile	NOUN
admet-1037	164	32	(	(	PUNCT
admet-1037	164	33	fig	fig	NOUN
admet-1037	164	34	.	.	PUNCT
admet-1037	164	35	6	6	NUM
admet-1037	164	36	)	)	PUNCT
admet-1037	164	37	.	.	PUNCT
admet-1037	165	1	both	both	DET
admet-1037	165	2	structures	structure	NOUN
admet-1037	165	3	incorporate	incorporate	VERB
admet-1037	165	4	a	a	DET
admet-1037	165	5	semirigid	semirigid	ADJ
admet-1037	165	6	linker	linker	NOUN
admet-1037	165	7	1-[(piperidin-4	1-[(piperidin-4	PROPN
admet-1037	165	8	-	-	PUNCT
admet-1037	165	9	yl)methyl]piperazine	yl)methyl]piperazine	PROPN
admet-1037	165	10	(	(	PUNCT
admet-1037	165	11	chemical	chemical	NOUN
admet-1037	165	12	structures	structure	NOUN
admet-1037	165	13	in	in	ADP
admet-1037	165	14	fig	fig	NOUN
admet-1037	165	15	.	.	PUNCT
admet-1037	166	1	s1	s1	NOUN
admet-1037	166	2	)	)	PUNCT
admet-1037	166	3	,	,	PUNCT
admet-1037	166	4	which	which	PRON
admet-1037	166	5	compared	compare	VERB
admet-1037	166	6	to	to	ADP
admet-1037	166	7	traditional	traditional	ADJ
admet-1037	166	8	pegylated	pegylate	VERB
admet-1037	166	9	or	or	CCONJ
admet-1037	166	10	alkyl	alkyl	ADJ
admet-1037	166	11	linkers	linker	NOUN
admet-1037	166	12	,	,	PUNCT
admet-1037	166	13	are	be	AUX
admet-1037	166	14	less	less	ADV
admet-1037	166	15	flexible	flexible	ADJ
admet-1037	166	16	.	.	PUNCT
admet-1037	167	1	considering	consider	VERB
admet-1037	167	2	the	the	DET
admet-1037	167	3	importance	importance	NOUN
admet-1037	167	4	of	of	ADP
admet-1037	167	5	flexibility	flexibility	NOUN
admet-1037	167	6	to	to	ADP
admet-1037	167	7	the	the	DET
admet-1037	167	8	formation	formation	NOUN
admet-1037	167	9	of	of	ADP
admet-1037	167	10	intramolecular	intramolecular	ADJ
admet-1037	167	11	hydrogen	hydrogen	NOUN
admet-1037	167	12	bonds	bond	NOUN
admet-1037	167	13	(	(	PUNCT
admet-1037	167	14	imhbs	imhbs	ADJ
admet-1037	167	15	)	)	PUNCT
admet-1037	167	16	,	,	PUNCT
admet-1037	167	17	these	these	DET
admet-1037	167	18	two	two	NUM
admet-1037	167	19	degraders	degrader	NOUN
admet-1037	167	20	occupy	occupy	VERB
admet-1037	167	21	a	a	DET
admet-1037	167	22	subregion	subregion	NOUN
admet-1037	167	23	where	where	SCONJ
admet-1037	167	24	,	,	PUNCT
admet-1037	167	25	at	at	ADP
admet-1037	167	26	least	least	ADJ
admet-1037	167	27	theoretically	theoretically	ADV
admet-1037	167	28	,	,	PUNCT
admet-1037	167	29	dynamic	dynamic	ADJ
admet-1037	167	30	imhbs	imhbs	NOUN
admet-1037	167	31	are	be	AUX
admet-1037	167	32	not	not	PART
admet-1037	167	33	favored	favor	VERB
admet-1037	167	34	[	[	X
admet-1037	167	35	28	28	NUM
admet-1037	167	36	]	]	X
admet-1037	167	37	(	(	PUNCT
admet-1037	167	38	a	a	DET
admet-1037	167	39	dynamic	dynamic	ADJ
admet-1037	167	40	imhb	imhb	NOUN
admet-1037	167	41	is	be	AUX
admet-1037	167	42	formed	form	VERB
admet-1037	167	43	in	in	ADP
admet-1037	167	44	nonpolar	nonpolar	ADJ
admet-1037	167	45	but	but	CCONJ
admet-1037	167	46	not	not	PART
admet-1037	167	47	in	in	ADP
admet-1037	167	48	polar	polar	ADJ
admet-1037	167	49	media	medium	NOUN
admet-1037	167	50	)	)	PUNCT
admet-1037	167	51	.	.	PUNCT
admet-1037	168	1	consequently	consequently	ADV
admet-1037	168	2	,	,	PUNCT
admet-1037	168	3	this	this	DET
admet-1037	168	4	structural	structural	ADJ
admet-1037	168	5	property	property	NOUN
admet-1037	168	6	profile	profile	NOUN
admet-1037	168	7	reduces	reduce	VERB
admet-1037	168	8	arvinas	arvinas	NOUN
admet-1037	168	9	degrader´s	degrader´s	NOUN
admet-1037	168	10	capacity	capacity	NOUN
admet-1037	168	11	to	to	PART
admet-1037	168	12	change	change	VERB
admet-1037	168	13	conformation	conformation	NOUN
admet-1037	168	14	in	in	ADP
admet-1037	168	15	an	an	DET
admet-1037	168	16	environment	environment	NOUN
admet-1037	168	17	-	-	PUNCT
admet-1037	168	18	dependent	dependent	ADJ
admet-1037	168	19	manner	manner	NOUN
admet-1037	168	20	,	,	PUNCT
admet-1037	168	21	that	that	ADV
admet-1037	168	22	is	is	ADV
admet-1037	168	23	,	,	PUNCT
admet-1037	168	24	to	to	PART
admet-1037	168	25	behave	behave	VERB
admet-1037	168	26	as	as	ADP
admet-1037	168	27	molecular	molecular	ADJ
admet-1037	168	28	chameleons	chameleon	NOUN
admet-1037	168	29	.	.	PUNCT
admet-1037	169	1	in	in	ADP
admet-1037	169	2	addition	addition	NOUN
admet-1037	169	3	,	,	PUNCT
admet-1037	169	4	arv-110	arv-110	ADJ
admet-1037	169	5	and	and	CCONJ
admet-1037	169	6	arv-471	arv-471	NOUN
admet-1037	169	7	have	have	VERB
admet-1037	169	8	a	a	DET
admet-1037	169	9	tpsa	tpsa	NOUN
admet-1037	169	10	value	value	NOUN
admet-1037	169	11	of	of	ADP
admet-1037	169	12	182.86	182.86	NUM
admet-1037	169	13	å2	å2	NOUN
admet-1037	169	14	and	and	CCONJ
admet-1037	169	15	96.43	96.43	NUM
admet-1037	169	16	å2	å2	NOUN
admet-1037	169	17	,	,	PUNCT
admet-1037	169	18	respectively	respectively	ADV
admet-1037	169	19	,	,	PUNCT
admet-1037	169	20	which	which	PRON
admet-1037	169	21	places	place	VERB
admet-1037	169	22	them	they	PRON
admet-1037	169	23	in	in	ADP
admet-1037	169	24	the	the	DET
admet-1037	169	25	first	first	ADJ
admet-1037	169	26	quartile	quartile	NOUN
admet-1037	169	27	(	(	PUNCT
admet-1037	169	28	tpsa	tpsa	NOUN
admet-1037	169	29	average=	average=	PROPN
admet-1037	169	30	240	240	NUM
admet-1037	169	31	å2	å2	NOUN
admet-1037	169	32	)	)	PUNCT
admet-1037	169	33	.	.	PUNCT
admet-1037	170	1	overall	overall	ADJ
admet-1037	170	2	,	,	PUNCT
admet-1037	170	3	after	after	ADP
admet-1037	170	4	analysing	analyse	VERB
admet-1037	170	5	their	their	PRON
admet-1037	170	6	properties	property	NOUN
admet-1037	170	7	it	it	PRON
admet-1037	170	8	could	could	AUX
admet-1037	170	9	be	be	AUX
admet-1037	170	10	stated	state	VERB
admet-1037	170	11	that	that	SCONJ
admet-1037	170	12	both	both	DET
admet-1037	170	13	degraders	degrader	NOUN
admet-1037	170	14	occupy	occupy	VERB
admet-1037	170	15	a	a	DET
admet-1037	170	16	superimposable	superimposable	ADJ
admet-1037	170	17	region	region	NOUN
admet-1037	170	18	to	to	ADP
admet-1037	170	19	that	that	PRON
admet-1037	170	20	of	of	ADP
admet-1037	170	21	oral	oral	ADJ
admet-1037	170	22	bro5	bro5	NOUN
admet-1037	170	23	drugs	drug	NOUN
admet-1037	170	24	:	:	PUNCT
admet-1037	170	25	(	(	PUNCT
admet-1037	170	26	nc	nc	NOUN
admet-1037	170	27	:	:	PUNCT
admet-1037	170	28	40	40	NUM
admet-1037	170	29	-	-	SYM
admet-1037	170	30	50	50	NUM
admet-1037	170	31	,	,	PUNCT
admet-1037	170	32	phi	phi	NOUN
admet-1037	170	33	:	:	PUNCT
admet-1037	170	34	10	10	NUM
admet-1037	170	35	-	-	SYM
admet-1037	170	36	15	15	NUM
admet-1037	170	37	and	and	CCONJ
admet-1037	170	38	tpsa	tpsa	PROPN
admet-1037	170	39	:	:	PUNCT
admet-1037	170	40	50	50	NUM
admet-1037	170	41	-	-	SYM
admet-1037	170	42	200	200	NUM
admet-1037	170	43	å	å	PROPN
admet-1037	170	44	2	2	NUM
admet-1037	170	45	)	)	PUNCT
admet-1037	170	46	(	(	PUNCT
admet-1037	170	47	fig	fig	NOUN
admet-1037	170	48	.	.	PUNCT
admet-1037	170	49	7	7	NUM
admet-1037	170	50	)	)	PUNCT
admet-1037	170	51	.	.	PUNCT
admet-1037	171	1	thus	thus	ADV
admet-1037	171	2	,	,	PUNCT
admet-1037	171	3	this	this	DET
admet-1037	171	4	drug	drug	NOUN
admet-1037	171	5	design	design	NOUN
admet-1037	171	6	strategy	strategy	NOUN
admet-1037	171	7	seems	seem	VERB
admet-1037	171	8	to	to	PART
admet-1037	171	9	have	have	AUX
admet-1037	171	10	prioritized	prioritize	VERB
admet-1037	171	11	candidates	candidate	NOUN
admet-1037	171	12	staying	stay	VERB
admet-1037	171	13	as	as	ADV
admet-1037	171	14	close	close	ADV
admet-1037	171	15	to	to	ADP
admet-1037	171	16	the	the	DET
admet-1037	171	17	ro5	ro5	ADJ
admet-1037	171	18	chemical	chemical	NOUN
admet-1037	171	19	space	space	NOUN
admet-1037	171	20	as	as	ADP
admet-1037	171	21	possible	possible	ADJ
admet-1037	171	22	.	.	PUNCT
admet-1037	172	1	figure	figure	VERB
admet-1037	172	2	7	7	NUM
admet-1037	172	3	.	.	PUNCT
admet-1037	172	4	a	a	X
admet-1037	172	5	)	)	PUNCT
admet-1037	172	6	radar	radar	NOUN
admet-1037	172	7	plot	plot	NOUN
admet-1037	172	8	comparing	compare	VERB
admet-1037	172	9	the	the	DET
admet-1037	172	10	seven	seven	NUM
admet-1037	172	11	2d	2d	NUM
admet-1037	172	12	descriptors	descriptor	NOUN
admet-1037	172	13	for	for	ADP
admet-1037	172	14	degraders	degrader	NOUN
admet-1037	172	15	and	and	CCONJ
admet-1037	172	16	orally	orally	ADV
admet-1037	172	17	approved	approve	VERB
admet-1037	172	18	bro5	bro5	NOUN
admet-1037	172	19	drugs	drug	NOUN
admet-1037	172	20	b	b	X
admet-1037	172	21	)	)	PUNCT
admet-1037	172	22	chemical	chemical	NOUN
admet-1037	172	23	space	space	NOUN
admet-1037	172	24	occupied	occupy	VERB
admet-1037	172	25	by	by	ADP
admet-1037	172	26	protacs	protac	NOUN
admet-1037	172	27	®	®	NOUN
admet-1037	172	28	and	and	CCONJ
admet-1037	172	29	bro5	bro5	NOUN
admet-1037	172	30	approved	approve	VERB
admet-1037	172	31	drugs	drug	NOUN
admet-1037	172	32	.	.	PUNCT
admet-1037	173	1	permeability	permeability	NOUN
admet-1037	173	2	is	be	AUX
admet-1037	173	3	one	one	NUM
admet-1037	173	4	of	of	ADP
admet-1037	173	5	the	the	DET
admet-1037	173	6	major	major	ADJ
admet-1037	173	7	determinants	determinant	NOUN
admet-1037	173	8	of	of	ADP
admet-1037	173	9	bioavailability	bioavailability	NOUN
admet-1037	173	10	.	.	PUNCT
admet-1037	174	1	it	it	PRON
admet-1037	174	2	is	be	AUX
admet-1037	174	3	physiologically	physiologically	ADV
admet-1037	174	4	defined	define	VERB
admet-1037	174	5	as	as	ADP
admet-1037	174	6	the	the	DET
admet-1037	174	7	ability	ability	NOUN
admet-1037	174	8	of	of	ADP
admet-1037	174	9	a	a	DET
admet-1037	174	10	compound	compound	NOUN
admet-1037	174	11	to	to	PART
admet-1037	174	12	pass	pass	VERB
admet-1037	174	13	across	across	ADP
admet-1037	174	14	biological	biological	ADJ
admet-1037	174	15	membranes	membrane	NOUN
admet-1037	174	16	and	and	CCONJ
admet-1037	174	17	is	be	AUX
admet-1037	174	18	determined	determine	VERB
admet-1037	174	19	in	in	ADP
admet-1037	174	20	vitro	vitro	X
admet-1037	174	21	with	with	ADP
admet-1037	174	22	different	different	ADJ
admet-1037	174	23	methods	method	NOUN
admet-1037	174	24	,	,	PUNCT
admet-1037	174	25	pampa	pampa	NOUN
admet-1037	174	26	and	and	CCONJ
admet-1037	174	27	caco-2	caco-2	NUM
admet-1037	174	28	being	be	AUX
admet-1037	174	29	the	the	DET
admet-1037	174	30	most	most	ADV
admet-1037	174	31	common	common	ADJ
admet-1037	174	32	ones	one	NOUN
admet-1037	174	33	(	(	PUNCT
admet-1037	174	34	a	a	DET
admet-1037	174	35	discussion	discussion	NOUN
admet-1037	174	36	about	about	ADP
admet-1037	174	37	the	the	DET
admet-1037	174	38	differences	difference	NOUN
admet-1037	174	39	between	between	ADP
admet-1037	174	40	the	the	DET
admet-1037	174	41	two	two	NUM
admet-1037	174	42	methods	method	NOUN
admet-1037	174	43	and	and	CCONJ
admet-1037	174	44	their	their	PRON
admet-1037	174	45	reliability	reliability	NOUN
admet-1037	174	46	when	when	SCONJ
admet-1037	174	47	applied	apply	VERB
admet-1037	174	48	to	to	ADP
admet-1037	174	49	bro5	bro5	NOUN
admet-1037	174	50	compounds	compound	NOUN
admet-1037	174	51	is	be	AUX
admet-1037	174	52	beyond	beyond	ADP
admet-1037	174	53	the	the	DET
admet-1037	174	54	aim	aim	NOUN
admet-1037	174	55	of	of	ADP
admet-1037	174	56	the	the	DET
admet-1037	174	57	paper	paper	NOUN
admet-1037	175	1	[	[	X
admet-1037	175	2	28,29	28,29	NUM
admet-1037	175	3	]	]	PUNCT
admet-1037	175	4	)	)	PUNCT
admet-1037	175	5	.	.	PUNCT
admet-1037	176	1	however	however	ADV
admet-1037	176	2	,	,	PUNCT
admet-1037	176	3	the	the	DET
admet-1037	176	4	limitations	limitation	NOUN
admet-1037	176	5	of	of	ADP
admet-1037	176	6	obtaining	obtain	VERB
admet-1037	176	7	reliable	reliable	ADJ
admet-1037	176	8	permeability	permeability	NOUN
admet-1037	176	9	data	datum	NOUN
admet-1037	176	10	for	for	ADP
admet-1037	176	11	large	large	ADJ
admet-1037	176	12	molecules	molecule	NOUN
admet-1037	176	13	[	[	X
admet-1037	176	14	27	27	NUM
admet-1037	176	15	]	]	PUNCT
admet-1037	176	16	suggest	suggest	VERB
admet-1037	176	17	that	that	SCONJ
admet-1037	176	18	degraders	degrader	NOUN
admet-1037	176	19	with	with	ADP
admet-1037	176	20	an	an	DET
admet-1037	176	21	apparent	apparent	ADJ
admet-1037	176	22	low	low	ADJ
admet-1037	176	23	passive	passive	ADJ
admet-1037	176	24	permeability	permeability	NOUN
admet-1037	176	25	could	could	AUX
admet-1037	176	26	surprisingly	surprisingly	ADV
admet-1037	176	27	display	display	VERB
admet-1037	176	28	decent	decent	ADJ
admet-1037	176	29	bioavailability	bioavailability	NOUN
admet-1037	176	30	values	value	NOUN
admet-1037	176	31	.	.	PUNCT
admet-1037	177	1	for	for	ADP
admet-1037	177	2	this	this	DET
admet-1037	177	3	reason	reason	NOUN
admet-1037	177	4	,	,	PUNCT
admet-1037	177	5	a	a	DET
admet-1037	177	6	set	set	NOUN
admet-1037	177	7	of	of	ADP
admet-1037	177	8	degraders	degrader	NOUN
admet-1037	177	9	showing	show	VERB
admet-1037	177	10	consistent	consistent	ADJ
admet-1037	177	11	permeability	permeability	NOUN
admet-1037	177	12	values	value	NOUN
admet-1037	177	13	were	be	AUX
admet-1037	177	14	identified	identify	VERB
admet-1037	177	15	:	:	PUNCT
admet-1037	177	16	protac1	protac1	NOUN
admet-1037	177	17	described	describe	VERB
admet-1037	177	18	by	by	ADP
admet-1037	177	19	kihlberg	kihlberg	PROPN
admet-1037	177	20	et	et	PROPN
admet-1037	177	21	al	al	PROPN
admet-1037	177	22	.	.	PUNCT
admet-1037	178	1	[	[	X
admet-1037	178	2	30	30	NUM
admet-1037	178	3	]	]	PUNCT
admet-1037	178	4	,	,	PUNCT
admet-1037	178	5	a	a	DET
admet-1037	178	6	small	small	ADJ
admet-1037	178	7	set	set	NOUN
admet-1037	178	8	provided	provide	VERB
admet-1037	178	9	for	for	ADP
admet-1037	178	10	free	free	ADJ
admet-1037	178	11	by	by	ADP
admet-1037	178	12	opnme	opnme	PROPN
admet-1037	178	13	(	(	PUNCT
admet-1037	178	14	www.opnme.com	www.opnme.com	X
admet-1037	178	15	)	)	PUNCT
admet-1037	179	1	[	[	X
admet-1037	179	2	25	25	NUM
admet-1037	179	3	]	]	PUNCT
admet-1037	179	4	,	,	PUNCT
admet-1037	179	5	protac-14	protac-14	PROPN
admet-1037	179	6	by	by	ADP
admet-1037	179	7	skidmore	skidmore	PROPN
admet-1037	179	8	et	et	PROPN
admet-1037	179	9	al	al	PROPN
admet-1037	179	10	.	.	PUNCT
admet-1037	180	1	[	[	X
admet-1037	180	2	31	31	NUM
admet-1037	180	3	]	]	PUNCT
admet-1037	180	4	and	and	CCONJ
admet-1037	180	5	11	11	NUM
admet-1037	180	6	degraders	degrader	NOUN
admet-1037	180	7	reported	report	VERB
admet-1037	180	8	by	by	ADP
admet-1037	180	9	lokey	lokey	PROPN
admet-1037	180	10	et	et	PROPN
admet-1037	180	11	al	al	PROPN
admet-1037	180	12	.	.	PUNCT
admet-1037	181	1	[	[	X
admet-1037	181	2	32	32	NUM
admet-1037	181	3	]	]	PUNCT
admet-1037	181	4	(	(	PUNCT
admet-1037	181	5	figure	figure	NOUN
admet-1037	181	6	s1	s1	NOUN
admet-1037	181	7	and	and	CCONJ
admet-1037	181	8	table	table	NOUN
admet-1037	181	9	s2	s2	PROPN
admet-1037	181	10	)	)	PUNCT
admet-1037	181	11	.	.	PUNCT
admet-1037	182	1	these	these	DET
admet-1037	182	2	degraders	degrader	NOUN
admet-1037	182	3	were	be	AUX
admet-1037	182	4	then	then	ADV
admet-1037	182	5	located	locate	VERB
admet-1037	182	6	into	into	ADP
admet-1037	182	7	the	the	DET
admet-1037	182	8	chemical	chemical	NOUN
admet-1037	182	9	space	space	NOUN
admet-1037	182	10	(	(	PUNCT
admet-1037	182	11	fig	fig	NOUN
admet-1037	182	12	.	.	PUNCT
admet-1037	183	1	9a	9a	NOUN
admet-1037	183	2	)	)	PUNCT
admet-1037	183	3	and	and	CCONJ
admet-1037	183	4	classified	classify	VERB
admet-1037	183	5	into	into	ADP
admet-1037	183	6	permeable	permeable	ADJ
admet-1037	183	7	(	(	PUNCT
admet-1037	183	8	papp	papp	X
admet-1037	183	9	>	>	X
admet-1037	183	10	1	1	NUM
admet-1037	183	11	x	x	SYM
admet-1037	183	12	10	10	NUM
admet-1037	183	13	-	-	SYM
admet-1037	183	14	6	6	NUM
admet-1037	183	15	cm	cm	NOUN
admet-1037	183	16	/	/	SYM
admet-1037	183	17	s	s	NOUN
admet-1037	183	18	)	)	PUNCT
admet-1037	183	19	or	or	CCONJ
admet-1037	183	20	low	low	ADJ
admet-1037	183	21	permeable	permeable	ADJ
admet-1037	183	22	(	(	PUNCT
admet-1037	183	23	papp	papp	X
admet-1037	183	24	<	<	X
admet-1037	183	25	1	1	NUM
admet-1037	183	26	x	x	SYM
admet-1037	183	27	10	10	NUM
admet-1037	183	28	-	-	SYM
admet-1037	183	29	6	6	NUM
admet-1037	183	30	cm	cm	NOUN
admet-1037	183	31	/	/	SYM
admet-1037	183	32	s	s	NOUN
admet-1037	183	33	)	)	PUNCT
admet-1037	183	34	(	(	PUNCT
admet-1037	183	35	fig	fig	NOUN
admet-1037	183	36	.	.	PUNCT
admet-1037	183	37	9b	9b	NUM
admet-1037	183	38	)	)	PUNCT
admet-1037	183	39	(	(	PUNCT
admet-1037	183	40	table	table	NOUN
admet-1037	183	41	s2	s2	PROPN
admet-1037	183	42	)	)	PUNCT
admet-1037	183	43	.	.	PUNCT
admet-1037	184	1	notably	notably	ADV
admet-1037	184	2	,	,	PUNCT
admet-1037	184	3	permeable	permeable	ADJ
admet-1037	184	4	degraders	degrader	NOUN
admet-1037	184	5	(	(	PUNCT
admet-1037	184	6	protac-1	protac-1	NOUN
admet-1037	184	7	,	,	PUNCT
admet-1037	184	8	protac-14	protac-14	PROPN
admet-1037	184	9	,	,	PUNCT
admet-1037	184	10	acbi1	acbi1	PROPN
admet-1037	184	11	and	and	CCONJ
admet-1037	184	12	bi-3663	bi-3663	PROPN
admet-1037	184	13	)	)	PUNCT
admet-1037	184	14	occupy	occupy	VERB
admet-1037	184	15	a	a	DET
admet-1037	184	16	central	central	ADJ
admet-1037	184	17	region	region	NOUN
admet-1037	184	18	of	of	ADP
admet-1037	184	19	the	the	DET
admet-1037	184	20	chemical	chemical	NOUN
admet-1037	184	21	space	space	NOUN
admet-1037	184	22	(	(	PUNCT
admet-1037	184	23	figure	figure	NOUN
admet-1037	184	24	9b	9b	NUM
admet-1037	184	25	)	)	PUNCT
admet-1037	184	26	.	.	PUNCT
admet-1037	185	1	among	among	ADP
admet-1037	185	2	them	they	PRON
admet-1037	185	3	,	,	PUNCT
admet-1037	185	4	bi-3663	bi-3663	NOUN
admet-1037	185	5	and	and	CCONJ
admet-1037	185	6	protac-14	protac-14	PROPN
admet-1037	185	7	,	,	PUNCT
admet-1037	185	8	are	be	AUX
admet-1037	185	9	the	the	DET
admet-1037	185	10	closest	close	ADJ
admet-1037	185	11	to	to	ADP
admet-1037	185	12	arvinas	arvina	NOUN
admet-1037	185	13	’s	’s	PART
admet-1037	185	14	compounds	compound	NOUN
admet-1037	185	15	.	.	PUNCT
admet-1037	186	1	in	in	ADP
admet-1037	186	2	particular	particular	ADJ
admet-1037	186	3	,	,	PUNCT
admet-1037	186	4	protac-14	protac-14	PROPN
admet-1037	186	5	is	be	AUX
admet-1037	186	6	the	the	DET
admet-1037	186	7	degrader	degrader	NOUN
admet-1037	186	8	showing	show	VERB
admet-1037	186	9	the	the	DET
admet-1037	186	10	best	good	ADJ
admet-1037	186	11	“	"	PUNCT
admet-1037	186	12	drug	drug	NOUN
admet-1037	186	13	-	-	PUNCT
admet-1037	186	14	like	like	ADJ
admet-1037	186	15	”	"	PUNCT
admet-1037	186	16	properties	property	NOUN
admet-1037	186	17	(	(	PUNCT
admet-1037	186	18	table	table	NOUN
admet-1037	186	19	s3	s3	PROPN
admet-1037	186	20	)	)	PUNCT
admet-1037	186	21	.	.	PUNCT
admet-1037	187	1	it	it	PRON
admet-1037	187	2	has	have	VERB
admet-1037	187	3	the	the	DET
admet-1037	187	4	structure	structure	NOUN
admet-1037	187	5	containing	contain	VERB
admet-1037	187	6	less	less	ADJ
admet-1037	187	7	nc	nc	PROPN
admet-1037	187	8	and	and	CCONJ
admet-1037	187	9	the	the	DET
admet-1037	187	10	lowest	low	ADJ
admet-1037	187	11	phi	phi	NOUN
admet-1037	187	12	and	and	CCONJ
admet-1037	187	13	tpsa	tpsa	NOUN
admet-1037	187	14	values	value	NOUN
admet-1037	187	15	.	.	PUNCT
admet-1037	188	1	moreover	moreover	ADV
admet-1037	188	2	,	,	PUNCT
admet-1037	188	3	bi-3663	bi-3663	PROPN
admet-1037	188	4	is	be	AUX
admet-1037	188	5	slightly	slightly	ADV
admet-1037	188	6	more	more	ADV
admet-1037	188	7	polar	polar	ADJ
admet-1037	188	8	than	than	ADP
admet-1037	188	9	acbi1	acbi1	PROPN
admet-1037	188	10	but	but	CCONJ
admet-1037	188	11	has	have	VERB
admet-1037	188	12	5	5	NUM
admet-1037	188	13	carbons	carbon	NOUN
admet-1037	188	14	less	less	ADV
admet-1037	188	15	and	and	CCONJ
admet-1037	188	16	thus	thus	ADV
admet-1037	188	17	is	be	AUX
admet-1037	188	18	closer	close	ADJ
admet-1037	188	19	to	to	ADP
admet-1037	188	20	arv-110	arv-110	NOUN
admet-1037	188	21	and	and	CCONJ
admet-1037	188	22	arv-471	arv-471	NOUN
admet-1037	188	23	.	.	PUNCT
admet-1037	189	1	finally	finally	ADV
admet-1037	189	2	,	,	PUNCT
admet-1037	189	3	protac-1	protac-1	NUM
admet-1037	189	4	has	have	VERB
admet-1037	189	5	a	a	DET
admet-1037	189	6	higher	high	ADJ
admet-1037	189	7	nc	nc	NOUN
admet-1037	189	8	(	(	PUNCT
admet-1037	189	9	50	50	NUM
admet-1037	189	10	)	)	PUNCT
admet-1037	189	11	,	,	PUNCT
admet-1037	189	12	tpsa	tpsa	NOUN
admet-1037	189	13	(	(	PUNCT
admet-1037	189	14	265	265	NUM
admet-1037	189	15	å2	å2	NOUN
admet-1037	189	16	)	)	PUNCT
admet-1037	189	17	and	and	CCONJ
admet-1037	189	18	phi	phi	NOUN
admet-1037	189	19	(	(	PUNCT
admet-1037	189	20	19	19	NUM
admet-1037	189	21	)	)	PUNCT
admet-1037	189	22	which	which	PRON
admet-1037	189	23	places	place	VERB
admet-1037	189	24	it	it	PRON
admet-1037	189	25	above	above	ADP
admet-1037	189	26	the	the	DET
admet-1037	189	27	other	other	ADJ
admet-1037	189	28	degraders	degrader	NOUN
admet-1037	189	29	.	.	PUNCT
admet-1037	190	1	protac-1	protac-1	NOUN
admet-1037	190	2	is	be	AUX
admet-1037	190	3	permeable	permeable	ADJ
admet-1037	190	4	although	although	SCONJ
admet-1037	190	5	large	large	ADJ
admet-1037	190	6	dimensions	dimension	NOUN
admet-1037	190	7	and	and	CCONJ
admet-1037	190	8	high	high	ADJ
admet-1037	190	9	tpsa	tpsa	NOUN
admet-1037	190	10	are	be	AUX
admet-1037	190	11	associated	associate	VERB
admet-1037	190	12	with	with	ADP
admet-1037	190	13	low	low	ADJ
admet-1037	190	14	permeability	permeability	NOUN
admet-1037	190	15	.	.	PUNCT
admet-1037	191	1	however	however	ADV
admet-1037	191	2	,	,	PUNCT
admet-1037	191	3	protac-1	protac-1	NUM
admet-1037	191	4	is	be	AUX
admet-1037	191	5	highly	highly	ADV
admet-1037	191	6	flexible	flexible	ADJ
admet-1037	191	7	and	and	CCONJ
admet-1037	191	8	thus	thus	ADV
admet-1037	191	9	capacity	capacity	NOUN
admet-1037	191	10	to	to	PART
admet-1037	191	11	form	form	VERB
admet-1037	191	12	http://www.opnme.com/	http://www.opnme.com/	ADJ
admet-1037	191	13	admet	admet	PROPN
admet-1037	191	14	&	&	CCONJ
admet-1037	191	15	dmpk	dmpk	PROPN
admet-1037	191	16	9(4	9(4	PROPN
admet-1037	191	17	)	)	PUNCT
admet-1037	191	18	(	(	PUNCT
admet-1037	191	19	2021	2021	NUM
admet-1037	191	20	)	)	PUNCT
admet-1037	191	21	243	243	NUM
admet-1037	191	22	-	-	SYM
admet-1037	191	23	254	254	NUM
admet-1037	191	24	are	be	AUX
admet-1037	191	25	we	we	PRON
admet-1037	191	26	ready	ready	ADJ
admet-1037	191	27	to	to	PART
admet-1037	191	28	design	design	VERB
admet-1037	191	29	oral	oral	ADJ
admet-1037	191	30	protacs	protacs	PROPN
admet-1037	191	31	®	®	NOUN
admet-1037	191	32	?	?	PUNCT
admet-1037	192	1	doi	doi	NOUN
admet-1037	192	2	:	:	PUNCT
admet-1037	192	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	ADP
admet-1037	192	4	251	251	NUM
admet-1037	192	5	dynamic	dynamic	ADJ
admet-1037	192	6	intramolecular	intramolecular	ADJ
admet-1037	192	7	interactions	interaction	NOUN
admet-1037	192	8	that	that	PRON
admet-1037	192	9	confer	confer	VERB
admet-1037	192	10	it	it	PRON
admet-1037	192	11	the	the	DET
admet-1037	192	12	capacity	capacity	NOUN
admet-1037	192	13	to	to	PART
admet-1037	192	14	behave	behave	VERB
admet-1037	192	15	as	as	ADP
admet-1037	192	16	a	a	DET
admet-1037	192	17	molecular	molecular	ADJ
admet-1037	192	18	chameleon	chameleon	NOUN
admet-1037	192	19	[	[	X
admet-1037	192	20	30	30	NUM
admet-1037	192	21	]	]	PUNCT
admet-1037	192	22	.	.	PUNCT
admet-1037	193	1	chameleonicity	chameleonicity	NOUN
admet-1037	193	2	therefore	therefore	ADV
admet-1037	193	3	could	could	AUX
admet-1037	193	4	explain	explain	VERB
admet-1037	193	5	why	why	SCONJ
admet-1037	193	6	protac-1	protac-1	NOUN
admet-1037	193	7	is	be	AUX
admet-1037	193	8	permeable	permeable	ADJ
admet-1037	193	9	despite	despite	SCONJ
admet-1037	193	10	its	its	PRON
admet-1037	193	11	position	position	NOUN
admet-1037	193	12	in	in	ADP
admet-1037	193	13	a	a	DET
admet-1037	193	14	less	less	ADJ
admet-1037	193	15	“	"	PUNCT
admet-1037	193	16	druglike	druglike	NOUN
admet-1037	193	17	”	"	PUNCT
admet-1037	193	18	region	region	NOUN
admet-1037	193	19	of	of	ADP
admet-1037	193	20	the	the	DET
admet-1037	193	21	protac	protac	ADJ
admet-1037	193	22	®	®	NOUN
admet-1037	193	23	chemical	chemical	NOUN
admet-1037	193	24	space	space	NOUN
admet-1037	193	25	.	.	PUNCT
admet-1037	194	1	figure	figure	NOUN
admet-1037	194	2	8	8	NUM
admet-1037	194	3	.	.	PUNCT
admet-1037	195	1	chemical	chemical	NOUN
admet-1037	195	2	space	space	NOUN
admet-1037	195	3	occupied	occupy	VERB
admet-1037	195	4	by	by	ADP
admet-1037	195	5	arv-110	arv-110	NOUN
admet-1037	195	6	and	and	CCONJ
admet-1037	195	7	arv-471	arv-471	NOUN
admet-1037	195	8	.	.	PUNCT
admet-1037	196	1	overall	overall	ADV
admet-1037	196	2	,	,	PUNCT
admet-1037	196	3	our	our	PRON
admet-1037	196	4	analysis	analysis	NOUN
admet-1037	196	5	suggests	suggest	VERB
admet-1037	196	6	that	that	SCONJ
admet-1037	196	7	permeable	permeable	ADJ
admet-1037	196	8	protacs	protac	NOUN
admet-1037	196	9	®	®	NOUN
admet-1037	196	10	could	could	AUX
admet-1037	196	11	be	be	AUX
admet-1037	196	12	located	locate	VERB
admet-1037	196	13	in	in	ADP
admet-1037	196	14	three	three	NUM
admet-1037	196	15	regions	region	NOUN
admet-1037	196	16	:	:	PUNCT
admet-1037	196	17	1	1	X
admet-1037	196	18	)	)	PUNCT
admet-1037	196	19	the	the	DET
admet-1037	196	20	subregion	subregion	NOUN
admet-1037	196	21	having	have	VERB
admet-1037	196	22	the	the	DET
admet-1037	196	23	“	"	PUNCT
admet-1037	196	24	best	good	ADJ
admet-1037	196	25	drug	drug	NOUN
admet-1037	196	26	”	"	PUNCT
admet-1037	196	27	like	like	ADP
admet-1037	196	28	properties	property	NOUN
admet-1037	196	29	(	(	PUNCT
admet-1037	196	30	smaller	small	ADJ
admet-1037	196	31	size	size	NOUN
admet-1037	196	32	,	,	PUNCT
admet-1037	196	33	lower	low	ADJ
admet-1037	196	34	polarity	polarity	NOUN
admet-1037	196	35	and	and	CCONJ
admet-1037	196	36	flexibility	flexibility	NOUN
admet-1037	196	37	)	)	PUNCT
admet-1037	196	38	(	(	PUNCT
admet-1037	196	39	protac-14	protac-14	NOUN
admet-1037	196	40	)	)	PUNCT
admet-1037	196	41	,	,	PUNCT
admet-1037	196	42	2	2	X
admet-1037	196	43	)	)	PUNCT
admet-1037	196	44	an	an	DET
admet-1037	196	45	intermediate	intermediate	ADJ
admet-1037	196	46	region	region	NOUN
admet-1037	196	47	with	with	ADP
admet-1037	196	48	acceptable	acceptable	ADJ
admet-1037	196	49	molecular	molecular	ADJ
admet-1037	196	50	properties	property	NOUN
admet-1037	196	51	(	(	PUNCT
admet-1037	196	52	bi-3663	bi-3663	NOUN
admet-1037	196	53	and	and	CCONJ
admet-1037	196	54	acbi1	acbi1	NUM
admet-1037	196	55	)	)	PUNCT
admet-1037	196	56	and	and	CCONJ
admet-1037	196	57	3	3	X
admet-1037	196	58	)	)	PUNCT
admet-1037	196	59	a	a	DET
admet-1037	196	60	region	region	NOUN
admet-1037	196	61	occupied	occupy	VERB
admet-1037	196	62	by	by	ADP
admet-1037	196	63	molecular	molecular	ADJ
admet-1037	196	64	chameleons	chameleon	NOUN
admet-1037	196	65	(	(	PUNCT
admet-1037	196	66	protac-1	protac-1	NOUN
admet-1037	196	67	)	)	PUNCT
admet-1037	196	68	.	.	PUNCT
admet-1037	197	1	however	however	ADV
admet-1037	197	2	,	,	PUNCT
admet-1037	197	3	since	since	SCONJ
admet-1037	197	4	chameleonicity	chameleonicity	NOUN
admet-1037	197	5	can	can	AUX
admet-1037	197	6	not	not	PART
admet-1037	197	7	be	be	AUX
admet-1037	197	8	only	only	ADV
admet-1037	197	9	explained	explain	VERB
admet-1037	197	10	on	on	ADP
admet-1037	197	11	the	the	DET
admet-1037	197	12	basis	basis	NOUN
admet-1037	197	13	of	of	ADP
admet-1037	197	14	2d	2d	PROPN
admet-1037	197	15	descriptors	descriptor	NOUN
admet-1037	197	16	(	(	PUNCT
admet-1037	197	17	the	the	DET
admet-1037	197	18	determinants	determinant	NOUN
admet-1037	197	19	of	of	ADP
admet-1037	197	20	chameleonicity	chameleonicity	NOUN
admet-1037	197	21	are	be	AUX
admet-1037	197	22	beyond	beyond	ADP
admet-1037	197	23	the	the	DET
admet-1037	197	24	scope	scope	NOUN
admet-1037	197	25	of	of	ADP
admet-1037	197	26	this	this	DET
admet-1037	197	27	paper	paper	NOUN
admet-1037	197	28	)	)	PUNCT
admet-1037	198	1	it	it	PRON
admet-1037	198	2	is	be	AUX
admet-1037	198	3	possible	possible	ADJ
admet-1037	198	4	that	that	SCONJ
admet-1037	198	5	molecular	molecular	ADJ
admet-1037	198	6	chameleons	chameleon	NOUN
admet-1037	198	7	with	with	ADP
admet-1037	198	8	optimal	optimal	ADJ
admet-1037	198	9	permeability	permeability	NOUN
admet-1037	198	10	could	could	AUX
admet-1037	198	11	occupy	occupy	VERB
admet-1037	198	12	further	further	ADJ
admet-1037	198	13	regions	region	NOUN
admet-1037	198	14	of	of	ADP
admet-1037	198	15	this	this	DET
admet-1037	198	16	2d	2d	NUM
admet-1037	198	17	property	property	NOUN
admet-1037	198	18	-	-	PUNCT
admet-1037	198	19	based	base	VERB
admet-1037	198	20	chemical	chemical	NOUN
admet-1037	198	21	space	space	NOUN
admet-1037	198	22	.	.	PUNCT
admet-1037	199	1	figure	figure	NOUN
admet-1037	199	2	9	9	NUM
admet-1037	199	3	.	.	PUNCT
admet-1037	200	1	chemical	chemical	ADJ
admet-1037	200	2	space	space	NOUN
admet-1037	200	3	of	of	ADP
admet-1037	200	4	a	a	DET
admet-1037	200	5	a	a	NOUN
admet-1037	200	6	)	)	PUNCT
admet-1037	200	7	subset	subset	NOUN
admet-1037	200	8	of	of	ADP
admet-1037	200	9	permeable	permeable	ADJ
admet-1037	200	10	degraders	degrader	NOUN
admet-1037	200	11	b	b	NOUN
admet-1037	200	12	)	)	PUNCT
admet-1037	200	13	graphical	graphical	ADJ
admet-1037	200	14	distribution	distribution	NOUN
admet-1037	200	15	of	of	ADP
admet-1037	200	16	highly	highly	ADV
admet-1037	200	17	permeable	permeable	ADJ
admet-1037	200	18	and	and	CCONJ
admet-1037	200	19	bioavailable	bioavailable	ADJ
admet-1037	200	20	degraders	degrader	NOUN
admet-1037	200	21	.	.	PUNCT
admet-1037	201	1	a	a	DET
admet-1037	201	2	b	b	X
admet-1037	201	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	PUNCT
admet-1037	201	4	g.	g.	PROPN
admet-1037	201	5	ermondi	ermondi	PROPN
admet-1037	201	6	et	et	PROPN
admet-1037	201	7	al	al	PROPN
admet-1037	201	8	.	.	PROPN
admet-1037	201	9	admet	admet	PROPN
admet-1037	201	10	&	&	CCONJ
admet-1037	201	11	dmpk	dmpk	PROPN
admet-1037	201	12	9(4	9(4	PROPN
admet-1037	201	13	)	)	PUNCT
admet-1037	201	14	(	(	PUNCT
admet-1037	201	15	2021	2021	NUM
admet-1037	201	16	)	)	PUNCT
admet-1037	201	17	243	243	NUM
admet-1037	201	18	-	-	SYM
admet-1037	201	19	254	254	NUM
admet-1037	201	20	252	252	NUM
admet-1037	201	21	conclusions	conclusion	NOUN
admet-1037	201	22	protacs	protac	NOUN
admet-1037	201	23	®	®	NOUN
admet-1037	201	24	are	be	AUX
admet-1037	201	25	an	an	DET
admet-1037	201	26	additional	additional	ADJ
admet-1037	201	27	modality	modality	NOUN
admet-1037	201	28	to	to	ADP
admet-1037	201	29	the	the	DET
admet-1037	201	30	drug	drug	NOUN
admet-1037	201	31	discovery	discovery	NOUN
admet-1037	201	32	toolbox	toolbox	NOUN
admet-1037	201	33	and	and	CCONJ
admet-1037	201	34	ad	ad	X
admet-1037	201	35	hoc	hoc	X
admet-1037	201	36	strategies	strategy	NOUN
admet-1037	201	37	to	to	PART
admet-1037	201	38	fully	fully	ADV
admet-1037	201	39	exploit	exploit	VERB
admet-1037	201	40	their	their	PRON
admet-1037	201	41	potential	potential	NOUN
admet-1037	201	42	as	as	SCONJ
admet-1037	201	43	oral	oral	ADJ
admet-1037	201	44	drugs	drug	NOUN
admet-1037	201	45	are	be	AUX
admet-1037	201	46	still	still	ADV
admet-1037	201	47	under	under	ADP
admet-1037	201	48	study	study	NOUN
admet-1037	201	49	.	.	PUNCT
admet-1037	202	1	in	in	ADP
admet-1037	202	2	this	this	DET
admet-1037	202	3	paper	paper	NOUN
admet-1037	202	4	,	,	PUNCT
admet-1037	202	5	we	we	PRON
admet-1037	202	6	first	first	ADV
admet-1037	202	7	explored	explore	VERB
admet-1037	202	8	the	the	DET
admet-1037	202	9	protac	protac	NOUN
admet-1037	202	10	-	-	PUNCT
admet-1037	202	11	db	db	NOUN
admet-1037	202	12	which	which	PRON
admet-1037	202	13	represents	represent	VERB
admet-1037	202	14	a	a	DET
admet-1037	202	15	useful	useful	ADJ
admet-1037	202	16	tool	tool	NOUN
admet-1037	202	17	for	for	ADP
admet-1037	202	18	degrader	degrad	ADJ
admet-1037	202	19	design	design	NOUN
admet-1037	202	20	.	.	PUNCT
admet-1037	203	1	in	in	ADP
admet-1037	203	2	particular	particular	ADJ
admet-1037	203	3	,	,	PUNCT
admet-1037	203	4	we	we	PRON
admet-1037	203	5	identified	identify	VERB
admet-1037	203	6	the	the	DET
admet-1037	203	7	most	most	ADV
admet-1037	203	8	popular	popular	ADJ
admet-1037	203	9	targets	target	NOUN
admet-1037	203	10	in	in	ADP
admet-1037	203	11	degrader	degrad	ADJ
admet-1037	203	12	technology	technology	NOUN
admet-1037	203	13	and	and	CCONJ
admet-1037	203	14	calculated	calculate	VERB
admet-1037	203	15	statistically	statistically	ADV
admet-1037	203	16	their	their	PRON
admet-1037	203	17	distribution	distribution	NOUN
admet-1037	203	18	.	.	PUNCT
admet-1037	204	1	e3	e3	NOUN
admet-1037	204	2	ligands	ligand	NOUN
admet-1037	204	3	have	have	AUX
admet-1037	204	4	been	be	AUX
admet-1037	204	5	revealed	reveal	VERB
admet-1037	204	6	to	to	PART
admet-1037	204	7	target	target	VERB
admet-1037	204	8	mainly	mainly	ADV
admet-1037	204	9	three	three	NUM
admet-1037	204	10	e3	e3	NOUN
admet-1037	204	11	ligase	ligase	NOUN
admet-1037	204	12	families	family	NOUN
admet-1037	204	13	(	(	PUNCT
admet-1037	204	14	vhl	vhl	NOUN
admet-1037	204	15	,	,	PUNCT
admet-1037	204	16	iaps	iap	NOUN
admet-1037	204	17	and	and	CCONJ
admet-1037	204	18	crbn	crbn	NOUN
admet-1037	204	19	)	)	PUNCT
admet-1037	204	20	that	that	PRON
admet-1037	204	21	represent	represent	VERB
admet-1037	204	22	up	up	ADP
admet-1037	204	23	to	to	PART
admet-1037	204	24	81	81	NUM
admet-1037	204	25	%	%	NOUN
admet-1037	204	26	of	of	ADP
admet-1037	204	27	the	the	DET
admet-1037	204	28	total	total	NOUN
admet-1037	204	29	.	.	PUNCT
admet-1037	205	1	warheads	warhead	NOUN
admet-1037	205	2	,	,	PUNCT
admet-1037	205	3	on	on	ADP
admet-1037	205	4	the	the	DET
admet-1037	205	5	contrary	contrary	NOUN
admet-1037	205	6	,	,	PUNCT
admet-1037	205	7	show	show	VERB
admet-1037	205	8	a	a	DET
admet-1037	205	9	heterogeneous	heterogeneous	ADJ
admet-1037	205	10	distribution	distribution	NOUN
admet-1037	205	11	in	in	ADP
admet-1037	205	12	which	which	PRON
admet-1037	205	13	only	only	ADV
admet-1037	205	14	2	2	NUM
admet-1037	205	15	%	%	NOUN
admet-1037	205	16	target	target	NOUN
admet-1037	205	17	the	the	DET
admet-1037	205	18	same	same	ADJ
admet-1037	205	19	poi	poi	NOUN
admet-1037	205	20	.	.	PUNCT
admet-1037	206	1	this	this	DET
admet-1037	206	2	high	high	ADJ
admet-1037	206	3	warhead	warhead	NOUN
admet-1037	206	4	variability	variability	NOUN
admet-1037	206	5	confers	confer	NOUN
admet-1037	206	6	protacs	protac	NOUN
admet-1037	206	7	®	®	VERB
admet-1037	206	8	the	the	DET
admet-1037	206	9	capacity	capacity	NOUN
admet-1037	206	10	to	to	PART
admet-1037	206	11	degrade	degrade	VERB
admet-1037	206	12	multiple	multiple	ADJ
admet-1037	206	13	targets	target	NOUN
admet-1037	206	14	,	,	PUNCT
admet-1037	206	15	being	be	AUX
admet-1037	206	16	the	the	DET
admet-1037	206	17	er	er	INTJ
admet-1037	206	18	the	the	DET
admet-1037	206	19	most	most	ADV
admet-1037	206	20	popular	popular	ADJ
admet-1037	206	21	target	target	NOUN
admet-1037	206	22	(	(	PUNCT
admet-1037	206	23	5	5	NUM
admet-1037	206	24	%	%	NOUN
admet-1037	206	25	)	)	PUNCT
admet-1037	206	26	.	.	PUNCT
admet-1037	207	1	the	the	DET
admet-1037	207	2	updated	update	VERB
admet-1037	207	3	version	version	NOUN
admet-1037	207	4	of	of	ADP
admet-1037	207	5	protac	protac	NOUN
admet-1037	207	6	-	-	PUNCT
admet-1037	207	7	db	db	NOUN
admet-1037	207	8	allowed	allow	VERB
admet-1037	207	9	us	we	PRON
admet-1037	207	10	to	to	PART
admet-1037	207	11	update	update	VERB
admet-1037	207	12	and	and	CCONJ
admet-1037	207	13	expand	expand	VERB
admet-1037	207	14	the	the	DET
admet-1037	207	15	protac	protac	ADJ
admet-1037	207	16	®	®	NOUN
admet-1037	207	17	chemical	chemical	NOUN
admet-1037	207	18	space	space	NOUN
admet-1037	207	19	previously	previously	ADV
admet-1037	207	20	described	describe	VERB
admet-1037	207	21	by	by	ADP
admet-1037	207	22	some	some	PRON
admet-1037	207	23	of	of	ADP
admet-1037	207	24	us	we	PRON
admet-1037	208	1	[	[	X
admet-1037	208	2	17	17	NUM
admet-1037	208	3	]	]	PUNCT
admet-1037	208	4	and	and	CCONJ
admet-1037	208	5	based	base	VERB
admet-1037	208	6	on	on	ADP
admet-1037	208	7	a	a	DET
admet-1037	208	8	set	set	NOUN
admet-1037	208	9	of	of	ADP
admet-1037	208	10	seven	seven	NUM
admet-1037	208	11	calculated	calculated	ADJ
admet-1037	208	12	2d	2d	NUM
admet-1037	208	13	descriptors	descriptor	NOUN
admet-1037	208	14	(	(	PUNCT
admet-1037	208	15	mw	mw	PROPN
admet-1037	208	16	,	,	PUNCT
admet-1037	208	17	nc	nc	PROPN
admet-1037	208	18	,	,	PUNCT
admet-1037	208	19	nar	nar	NOUN
admet-1037	208	20	,	,	PUNCT
admet-1037	208	21	phi	phi	NOUN
admet-1037	208	22	,	,	PUNCT
admet-1037	208	23	nhdon	nhdon	PROPN
admet-1037	208	24	,	,	PUNCT
admet-1037	208	25	nhacc	nhacc	NOUN
admet-1037	208	26	and	and	CCONJ
admet-1037	208	27	tpsa	tpsa	PROPN
admet-1037	208	28	)	)	PUNCT
admet-1037	208	29	.	.	PUNCT
admet-1037	209	1	then	then	ADV
admet-1037	209	2	we	we	PRON
admet-1037	209	3	compared	compare	VERB
admet-1037	209	4	the	the	DET
admet-1037	209	5	protac	protac	ADJ
admet-1037	209	6	®	®	NOUN
admet-1037	209	7	with	with	ADP
admet-1037	209	8	an	an	DET
admet-1037	209	9	orally	orally	ADV
admet-1037	209	10	approved	approve	VERB
admet-1037	209	11	bro5	bro5	NOUN
admet-1037	209	12	drugs	drug	NOUN
admet-1037	209	13	chemical	chemical	ADJ
admet-1037	209	14	space	space	NOUN
admet-1037	209	15	and	and	CCONJ
admet-1037	209	16	provided	provide	VERB
admet-1037	209	17	for	for	ADP
admet-1037	209	18	the	the	DET
admet-1037	209	19	first	first	ADJ
admet-1037	209	20	-	-	PUNCT
admet-1037	209	21	time	time	NOUN
admet-1037	209	22	initial	initial	ADJ
admet-1037	209	23	insights	insight	NOUN
admet-1037	209	24	on	on	ADP
admet-1037	209	25	the	the	DET
admet-1037	209	26	location	location	NOUN
admet-1037	209	27	of	of	ADP
admet-1037	209	28	bioavailable	bioavailable	ADJ
admet-1037	209	29	(	(	PUNCT
admet-1037	209	30	arv-110	arv-110	ADJ
admet-1037	209	31	and	and	CCONJ
admet-1037	209	32	arv-471	arv-471	NOUN
admet-1037	209	33	)	)	PUNCT
admet-1037	209	34	and	and	CCONJ
admet-1037	209	35	a	a	DET
admet-1037	209	36	small	small	ADJ
admet-1037	209	37	dataset	dataset	NOUN
admet-1037	209	38	of	of	ADP
admet-1037	209	39	permeable	permeable	ADJ
admet-1037	209	40	protacs	protac	NOUN
admet-1037	209	41	®	®	NOUN
admet-1037	209	42	.	.	PUNCT
admet-1037	210	1	results	result	NOUN
admet-1037	210	2	show	show	VERB
admet-1037	210	3	that	that	SCONJ
admet-1037	210	4	bioavailable	bioavailable	ADJ
admet-1037	210	5	degraders	degrader	NOUN
admet-1037	210	6	are	be	AUX
admet-1037	210	7	close	close	ADJ
admet-1037	210	8	to	to	ADP
admet-1037	210	9	the	the	DET
admet-1037	210	10	oral	oral	ADJ
admet-1037	210	11	bro5	bro5	NOUN
admet-1037	210	12	region	region	NOUN
admet-1037	210	13	whereas	whereas	SCONJ
admet-1037	210	14	permeable	permeable	ADJ
admet-1037	210	15	protacs	protac	NOUN
admet-1037	210	16	®	®	NOUN
admet-1037	210	17	seem	seem	VERB
admet-1037	210	18	to	to	PART
admet-1037	210	19	occupy	occupy	VERB
admet-1037	210	20	an	an	DET
admet-1037	210	21	extended	extended	ADJ
admet-1037	210	22	and	and	CCONJ
admet-1037	210	23	central	central	ADJ
admet-1037	210	24	region	region	NOUN
admet-1037	210	25	of	of	ADP
admet-1037	210	26	the	the	DET
admet-1037	210	27	chemical	chemical	NOUN
admet-1037	210	28	space	space	NOUN
admet-1037	210	29	.	.	PUNCT
admet-1037	211	1	in	in	ADP
admet-1037	211	2	addition	addition	NOUN
admet-1037	211	3	,	,	PUNCT
admet-1037	211	4	the	the	DET
admet-1037	211	5	fact	fact	NOUN
admet-1037	211	6	that	that	SCONJ
admet-1037	211	7	chameleonicity	chameleonicity	NOUN
admet-1037	211	8	can	can	AUX
admet-1037	211	9	improve	improve	VERB
admet-1037	211	10	permeability	permeability	NOUN
admet-1037	211	11	could	could	AUX
admet-1037	211	12	locate	locate	VERB
admet-1037	211	13	molecular	molecular	ADJ
admet-1037	211	14	chameleons	chameleon	NOUN
admet-1037	211	15	towards	towards	ADP
admet-1037	211	16	the	the	DET
admet-1037	211	17	less	less	ADJ
admet-1037	211	18	“	"	PUNCT
admet-1037	211	19	drug	drug	NOUN
admet-1037	211	20	-	-	PUNCT
admet-1037	211	21	like	like	ADJ
admet-1037	211	22	”	"	PUNCT
admet-1037	211	23	region	region	NOUN
admet-1037	211	24	of	of	ADP
admet-1037	211	25	the	the	DET
admet-1037	211	26	chemical	chemical	NOUN
admet-1037	211	27	space	space	NOUN
admet-1037	211	28	.	.	PUNCT
admet-1037	212	1	overall	overall	ADV
admet-1037	212	2	,	,	PUNCT
admet-1037	212	3	we	we	PRON
admet-1037	212	4	proved	prove	VERB
admet-1037	212	5	that	that	SCONJ
admet-1037	212	6	the	the	DET
admet-1037	212	7	chemical	chemical	NOUN
admet-1037	212	8	space	space	NOUN
admet-1037	212	9	using	use	VERB
admet-1037	212	10	nc	nc	PROPN
admet-1037	212	11	,	,	PUNCT
admet-1037	212	12	tpsa	tpsa	NOUN
admet-1037	212	13	and	and	CCONJ
admet-1037	212	14	phi	phi	NOUN
admet-1037	212	15	helps	help	VERB
admet-1037	212	16	to	to	PART
admet-1037	212	17	identify	identify	VERB
admet-1037	212	18	regions	region	NOUN
admet-1037	212	19	of	of	ADP
admet-1037	212	20	protacs	protac	NOUN
admet-1037	212	21	®	®	NOUN
admet-1037	212	22	with	with	ADP
admet-1037	212	23	future	future	NOUN
admet-1037	212	24	as	as	ADP
admet-1037	212	25	oral	oral	ADJ
admet-1037	212	26	drugs	drug	NOUN
admet-1037	212	27	if	if	SCONJ
admet-1037	212	28	permeability	permeability	NOUN
admet-1037	212	29	/	/	SYM
admet-1037	212	30	bioavailability	bioavailability	NOUN
admet-1037	212	31	data	datum	NOUN
admet-1037	212	32	are	be	AUX
admet-1037	212	33	available	available	ADJ
admet-1037	212	34	.	.	PUNCT
admet-1037	213	1	since	since	SCONJ
admet-1037	213	2	limitations	limitation	NOUN
admet-1037	213	3	associated	associate	VERB
admet-1037	213	4	to	to	ADP
admet-1037	213	5	the	the	DET
admet-1037	213	6	measurement	measurement	NOUN
admet-1037	213	7	of	of	ADP
admet-1037	213	8	bro5	bro5	NOUN
admet-1037	213	9	permeability	permeability	NOUN
admet-1037	213	10	are	be	AUX
admet-1037	213	11	known	know	VERB
admet-1037	213	12	,	,	PUNCT
admet-1037	213	13	the	the	DET
admet-1037	213	14	determination	determination	NOUN
admet-1037	213	15	of	of	ADP
admet-1037	213	16	experimental	experimental	ADJ
admet-1037	213	17	physicochemical	physicochemical	ADJ
admet-1037	213	18	descriptors	descriptor	NOUN
admet-1037	213	19	able	able	ADJ
admet-1037	213	20	to	to	PART
admet-1037	213	21	predict	predict	VERB
admet-1037	213	22	permeability	permeability	NOUN
admet-1037	213	23	could	could	AUX
admet-1037	213	24	accelerate	accelerate	VERB
admet-1037	213	25	the	the	DET
admet-1037	213	26	identification	identification	NOUN
admet-1037	213	27	of	of	ADP
admet-1037	213	28	new	new	ADJ
admet-1037	213	29	oral	oral	ADJ
admet-1037	213	30	protacs	protacs	PROPN
admet-1037	213	31	®	®	NOUN
admet-1037	213	32	.	.	PUNCT
admet-1037	214	1	studies	study	NOUN
admet-1037	214	2	along	along	ADP
admet-1037	214	3	these	these	DET
admet-1037	214	4	lines	line	NOUN
admet-1037	214	5	are	be	AUX
admet-1037	214	6	in	in	ADP
admet-1037	214	7	due	due	ADJ
admet-1037	214	8	course	course	NOUN
admet-1037	214	9	in	in	ADP
admet-1037	214	10	our	our	PRON
admet-1037	214	11	laboratories	laboratory	NOUN
admet-1037	214	12	.	.	PUNCT
admet-1037	215	1	acknowledgements	acknowledgement	NOUN
admet-1037	215	2	:	:	PUNCT
admet-1037	215	3	the	the	DET
admet-1037	215	4	authors	author	NOUN
admet-1037	215	5	thank	thank	VERB
admet-1037	215	6	the	the	DET
admet-1037	215	7	university	university	NOUN
admet-1037	215	8	of	of	ADP
admet-1037	215	9	torino	torino	PROPN
admet-1037	215	10	(	(	PUNCT
admet-1037	215	11	ricerca	ricerca	X
admet-1037	215	12	locale	locale	NOUN
admet-1037	215	13	ex-60	ex-60	X
admet-1037	215	14	%	%	INTJ
admet-1037	215	15	,	,	PUNCT
admet-1037	215	16	bando2020	bando2020	PROPN
admet-1037	215	17	)	)	PUNCT
admet-1037	215	18	for	for	ADP
admet-1037	215	19	financial	financial	ADJ
admet-1037	215	20	support	support	NOUN
admet-1037	215	21	.	.	PUNCT
admet-1037	216	1	conflict	conflict	NOUN
admet-1037	216	2	of	of	ADP
admet-1037	216	3	interest	interest	NOUN
admet-1037	216	4	:	:	PUNCT
admet-1037	216	5	the	the	DET
admet-1037	216	6	authors	author	NOUN
admet-1037	216	7	declare	declare	VERB
admet-1037	216	8	no	no	DET
admet-1037	216	9	conflict	conflict	NOUN
admet-1037	216	10	of	of	ADP
admet-1037	216	11	interest	interest	NOUN
admet-1037	216	12	.	.	PUNCT
admet-1037	217	1	references	reference	NOUN
admet-1037	217	2	[	[	X
admet-1037	217	3	1	1	NUM
admet-1037	217	4	]	]	PUNCT
admet-1037	217	5	w.	w.	PROPN
admet-1037	217	6	yang	yang	PROPN
admet-1037	217	7	,	,	PUNCT
admet-1037	217	8	p.	p.	NOUN
admet-1037	217	9	gadgil	gadgil	PROPN
admet-1037	217	10	,	,	PUNCT
admet-1037	217	11	v.r	v.r	PROPN
admet-1037	217	12	.	.	PROPN
admet-1037	217	13	krishnamurthy	krishnamurthy	PROPN
admet-1037	217	14	,	,	PUNCT
admet-1037	217	15	m.	m.	NOUN
admet-1037	217	16	landis	landis	PROPN
admet-1037	217	17	,	,	PUNCT
admet-1037	217	18	p.	p.	PROPN
admet-1037	217	19	mallick	mallick	PROPN
admet-1037	217	20	,	,	PUNCT
admet-1037	217	21	d.	d.	PROPN
admet-1037	217	22	patel	patel	PROPN
admet-1037	217	23	,	,	PUNCT
admet-1037	217	24	p.j	p.j	PROPN
admet-1037	217	25	.	.	PROPN
admet-1037	217	26	patel	patel	PROPN
admet-1037	217	27	,	,	PUNCT
admet-1037	217	28	d.l	d.l	PROPN
admet-1037	217	29	.	.	PROPN
admet-1037	217	30	reid	reid	PROPN
admet-1037	217	31	,	,	PUNCT
admet-1037	217	32	m.	m.	PROPN
admet-1037	217	33	sanchez	sanchez	PROPN
admet-1037	217	34	-	-	PUNCT
admet-1037	217	35	felix	felix	PROPN
admet-1037	217	36	.	.	PUNCT
admet-1037	218	1	the	the	DET
admet-1037	218	2	evolving	evolve	VERB
admet-1037	218	3	druggability	druggability	NOUN
admet-1037	218	4	and	and	CCONJ
admet-1037	218	5	developability	developability	NOUN
admet-1037	218	6	space	space	NOUN
admet-1037	218	7	:	:	PUNCT
admet-1037	218	8	chemically	chemically	ADV
admet-1037	218	9	modified	modify	VERB
admet-1037	218	10	new	new	ADJ
admet-1037	218	11	modalities	modality	NOUN
admet-1037	218	12	and	and	CCONJ
admet-1037	218	13	emerging	emerge	VERB
admet-1037	218	14	small	small	ADJ
admet-1037	218	15	molecules	molecule	NOUN
admet-1037	218	16	.	.	PUNCT
admet-1037	219	1	the	the	DET
admet-1037	219	2	aaps	aaps	PROPN
admet-1037	219	3	journal	journal	PROPN
admet-1037	219	4	22	22	NUM
admet-1037	219	5	(	(	PUNCT
admet-1037	219	6	2020	2020	NUM
admet-1037	219	7	)	)	PUNCT
admet-1037	219	8	21	21	NUM
admet-1037	219	9	.	.	PUNCT
admet-1037	220	1	https://doi.org/10.1208/s12248-019-0402-2	https://doi.org/10.1208/s12248-019-0402-2	X
admet-1037	220	2	.	.	PUNCT
admet-1037	221	1	[	[	X
admet-1037	221	2	2	2	X
admet-1037	221	3	]	]	PUNCT
admet-1037	221	4	s.	s.	PROPN
admet-1037	221	5	an	an	PROPN
admet-1037	221	6	,	,	PUNCT
admet-1037	221	7	l.	l.	PROPN
admet-1037	221	8	fu	fu	PROPN
admet-1037	221	9	.	.	PUNCT
admet-1037	222	1	small	small	ADJ
admet-1037	222	2	-	-	PUNCT
admet-1037	222	3	molecule	molecule	NOUN
admet-1037	222	4	protacs	protac	NOUN
admet-1037	222	5	:	:	PUNCT
admet-1037	222	6	an	an	DET
admet-1037	222	7	emerging	emerge	VERB
admet-1037	222	8	and	and	CCONJ
admet-1037	222	9	promising	promising	ADJ
admet-1037	222	10	approach	approach	NOUN
admet-1037	222	11	for	for	ADP
admet-1037	222	12	the	the	DET
admet-1037	222	13	development	development	NOUN
admet-1037	222	14	of	of	ADP
admet-1037	222	15	targeted	target	VERB
admet-1037	222	16	therapy	therapy	NOUN
admet-1037	222	17	drugs	drug	NOUN
admet-1037	222	18	.	.	PUNCT
admet-1037	223	1	ebiomedicine	ebiomedicine	VERB
admet-1037	223	2	36	36	NUM
admet-1037	223	3	(	(	PUNCT
admet-1037	223	4	2018	2018	NUM
admet-1037	223	5	)	)	PUNCT
admet-1037	223	6	553–562	553–562	NUM
admet-1037	223	7	.	.	PUNCT
admet-1037	224	1	https://doi.org/10.1016/j.ebiom.2018.09.005	https://doi.org/10.1016/j.ebiom.2018.09.005	PROPN
admet-1037	224	2	.	.	PUNCT
admet-1037	225	1	[	[	X
admet-1037	225	2	3	3	X
admet-1037	225	3	]	]	X
admet-1037	225	4	d.p	d.p	PROPN
admet-1037	225	5	.	.	PROPN
admet-1037	225	6	bondeson	bondeson	PROPN
admet-1037	225	7	,	,	PUNCT
admet-1037	225	8	a.	a.	NOUN
admet-1037	225	9	mares	mare	NOUN
admet-1037	225	10	,	,	PUNCT
admet-1037	226	1	i.e.d	i.e.d	NOUN
admet-1037	226	2	.	.	PUNCT
admet-1037	227	1	smith	smith	PROPN
admet-1037	227	2	,	,	PUNCT
admet-1037	227	3	e.	e.	PROPN
admet-1037	227	4	ko	ko	PROPN
admet-1037	227	5	,	,	PUNCT
admet-1037	227	6	s.	s.	PROPN
admet-1037	227	7	campos	campos	PROPN
admet-1037	227	8	,	,	PUNCT
admet-1037	227	9	a.h	a.h	PROPN
admet-1037	227	10	.	.	PROPN
admet-1037	227	11	miah	miah	PROPN
admet-1037	227	12	,	,	PUNCT
admet-1037	227	13	k.e	k.e	PROPN
admet-1037	227	14	.	.	PROPN
admet-1037	227	15	mulholland	mulholland	PROPN
admet-1037	227	16	,	,	PUNCT
admet-1037	227	17	n.	n.	PROPN
admet-1037	227	18	routly	routly	ADV
admet-1037	227	19	,	,	PUNCT
admet-1037	227	20	d.l	d.l	PROPN
admet-1037	227	21	.	.	PROPN
admet-1037	227	22	buckley	buckley	PROPN
admet-1037	227	23	,	,	PUNCT
admet-1037	227	24	j.l	j.l	PROPN
admet-1037	227	25	.	.	PROPN
admet-1037	227	26	gustafson	gustafson	PROPN
admet-1037	227	27	,	,	PUNCT
admet-1037	227	28	n.	n.	PROPN
admet-1037	227	29	zinn	zinn	PROPN
admet-1037	227	30	,	,	PUNCT
admet-1037	227	31	p.	p.	PROPN
admet-1037	227	32	grandi	grandi	PROPN
admet-1037	227	33	,	,	PUNCT
admet-1037	227	34	s.	s.	PROPN
admet-1037	227	35	shimamura	shimamura	PROPN
admet-1037	227	36	,	,	PUNCT
admet-1037	227	37	g.	g.	PROPN
admet-1037	227	38	bergamini	bergamini	PROPN
admet-1037	227	39	,	,	PUNCT
admet-1037	227	40	m.	m.	NOUN
admet-1037	227	41	faelth	faelth	NOUN
admet-1037	227	42	-	-	PUNCT
admet-1037	227	43	savitski	savitski	NOUN
admet-1037	227	44	,	,	PUNCT
admet-1037	227	45	m.	m.	NOUN
admet-1037	227	46	bantscheff	bantscheff	PROPN
admet-1037	227	47	,	,	PUNCT
admet-1037	227	48	c.	c.	PROPN
admet-1037	227	49	cox	cox	PROPN
admet-1037	227	50	,	,	PUNCT
admet-1037	227	51	d.a	d.a	PROPN
admet-1037	227	52	.	.	PROPN
admet-1037	227	53	gordon	gordon	PROPN
admet-1037	227	54	,	,	PUNCT
admet-1037	227	55	r.r	r.r	PROPN
admet-1037	227	56	.	.	PROPN
admet-1037	227	57	willard	willard	PROPN
admet-1037	227	58	,	,	PUNCT
admet-1037	227	59	j.j	j.j	PROPN
admet-1037	227	60	.	.	PROPN
admet-1037	227	61	flanagan	flanagan	PROPN
admet-1037	227	62	,	,	PUNCT
admet-1037	227	63	l.n	l.n	PROPN
admet-1037	227	64	.	.	PROPN
admet-1037	227	65	casillas	casillas	PROPN
admet-1037	227	66	,	,	PUNCT
admet-1037	227	67	b.j	b.j	PROPN
admet-1037	227	68	.	.	PROPN
admet-1037	227	69	votta	votta	PROPN
admet-1037	227	70	,	,	PUNCT
admet-1037	227	71	w.	w.	PROPN
admet-1037	227	72	den	den	PROPN
admet-1037	227	73	besten	besten	PROPN
admet-1037	227	74	,	,	PUNCT
admet-1037	227	75	k.	k.	PROPN
admet-1037	227	76	famm	famm	PROPN
admet-1037	227	77	,	,	PUNCT
admet-1037	227	78	l.	l.	PROPN
admet-1037	227	79	kruidenier	kruidenier	PROPN
admet-1037	227	80	,	,	PUNCT
admet-1037	227	81	p.s	p.s	PROPN
admet-1037	227	82	.	.	PROPN
admet-1037	227	83	carter	carter	PROPN
admet-1037	227	84	,	,	PUNCT
admet-1037	227	85	j.d	j.d	PROPN
admet-1037	227	86	.	.	PROPN
admet-1037	227	87	harling	harling	PROPN
admet-1037	227	88	,	,	PUNCT
admet-1037	227	89	i.	i.	PROPN
admet-1037	227	90	churcher	churcher	PROPN
admet-1037	227	91	,	,	PUNCT
admet-1037	227	92	c.m	c.m	PROPN
admet-1037	227	93	.	.	PROPN
admet-1037	227	94	crews	crew	NOUN
admet-1037	227	95	.	.	PUNCT
admet-1037	228	1	catalytic	catalytic	ADJ
admet-1037	228	2	in	in	ADP
admet-1037	228	3	vivo	vivo	NOUN
admet-1037	228	4	protein	protein	NOUN
admet-1037	228	5	knockdown	knockdown	NOUN
admet-1037	228	6	by	by	ADP
admet-1037	228	7	small	small	ADJ
admet-1037	228	8	-	-	PUNCT
admet-1037	228	9	molecule	molecule	NOUN
admet-1037	228	10	protacs	protac	NOUN
admet-1037	228	11	.	.	PUNCT
admet-1037	229	1	nature	nature	NOUN
admet-1037	229	2	chemical	chemical	NOUN
admet-1037	229	3	biology	biology	NOUN
admet-1037	229	4	11	11	NUM
admet-1037	229	5	(	(	PUNCT
admet-1037	229	6	2015	2015	NUM
admet-1037	229	7	)	)	PUNCT
admet-1037	229	8	611–617	611–617	NUM
admet-1037	229	9	.	.	PUNCT
admet-1037	229	10	https://doi.org/10.1038/nchembio.1858	https://doi.org/10.1038/nchembio.1858	NOUN
admet-1037	229	11	.	.	PUNCT
admet-1037	230	1	[	[	X
admet-1037	230	2	4	4	NUM
admet-1037	230	3	]	]	X
admet-1037	230	4	c.m	c.m	NOUN
admet-1037	230	5	.	.	PROPN
admet-1037	230	6	crews	crew	NOUN
admet-1037	230	7	.	.	PUNCT
admet-1037	231	1	targeting	target	VERB
admet-1037	231	2	the	the	DET
admet-1037	231	3	undruggable	undruggable	ADJ
admet-1037	231	4	proteome	proteome	NOUN
admet-1037	231	5	:	:	PUNCT
admet-1037	231	6	the	the	DET
admet-1037	231	7	small	small	ADJ
admet-1037	231	8	molecules	molecule	NOUN
admet-1037	231	9	of	of	ADP
admet-1037	231	10	my	my	PRON
admet-1037	231	11	dreams	dream	NOUN
admet-1037	231	12	.	.	PUNCT
admet-1037	232	1	chemistry	chemistry	NOUN
admet-1037	232	2	&	&	CCONJ
admet-1037	232	3	biology	biology	PROPN
admet-1037	232	4	17	17	NUM
admet-1037	232	5	(	(	PUNCT
admet-1037	232	6	2010	2010	NUM
admet-1037	232	7	)	)	PUNCT
admet-1037	232	8	551–555	551–555	NUM
admet-1037	232	9	.	.	PUNCT
admet-1037	233	1	https://doi.org/10.1016/j.chembiol.2010.05.011	https://doi.org/10.1016/j.chembiol.2010.05.011	NOUN
admet-1037	233	2	.	.	PUNCT
admet-1037	233	3	https://doi.org/10.1208/s12248-019-0402-2	https://doi.org/10.1208/s12248-019-0402-2	PROPN
admet-1037	233	4	https://doi.org/10.1208/s12248-019-0402-2	https://doi.org/10.1208/s12248-019-0402-2	PROPN
admet-1037	233	5	https://doi.org/10.1016/j.ebiom.2018.09.005	https://doi.org/10.1016/j.ebiom.2018.09.005	PROPN
admet-1037	233	6	https://doi.org/10.1016/j.ebiom.2018.09.005	https://doi.org/10.1016/j.ebiom.2018.09.005	PROPN
admet-1037	233	7	https://doi.org/10.1038/nchembio.1858	https://doi.org/10.1038/nchembio.1858	NOUN
admet-1037	233	8	https://doi.org/10.1016/j.chembiol.2010.05.011	https://doi.org/10.1016/j.chembiol.2010.05.011	NUM
admet-1037	233	9	admet	admet	PROPN
admet-1037	233	10	&	&	CCONJ
admet-1037	233	11	dmpk	dmpk	PROPN
admet-1037	233	12	9(4	9(4	PROPN
admet-1037	233	13	)	)	PUNCT
admet-1037	233	14	(	(	PUNCT
admet-1037	233	15	2021	2021	NUM
admet-1037	233	16	)	)	PUNCT
admet-1037	233	17	243	243	NUM
admet-1037	233	18	-	-	SYM
admet-1037	233	19	254	254	NUM
admet-1037	233	20	are	be	AUX
admet-1037	233	21	we	we	PRON
admet-1037	233	22	ready	ready	ADJ
admet-1037	233	23	to	to	PART
admet-1037	233	24	design	design	VERB
admet-1037	233	25	oral	oral	ADJ
admet-1037	233	26	protacs	protacs	PROPN
admet-1037	233	27	®	®	NOUN
admet-1037	233	28	?	?	PUNCT
admet-1037	234	1	doi	doi	NOUN
admet-1037	234	2	:	:	PUNCT
admet-1037	234	3	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	NUM
admet-1037	234	4	253	253	NUM
admet-1037	234	5	[	[	X
admet-1037	234	6	5	5	NUM
admet-1037	234	7	]	]	PUNCT
admet-1037	234	8	x.	x.	NOUN
admet-1037	234	9	liu	liu	PROPN
admet-1037	234	10	,	,	PUNCT
admet-1037	234	11	x.	x.	PROPN
admet-1037	234	12	zhang	zhang	PROPN
admet-1037	234	13	,	,	PUNCT
admet-1037	234	14	d.	d.	PROPN
admet-1037	234	15	lv	lv	PROPN
admet-1037	234	16	,	,	PUNCT
admet-1037	234	17	y.	y.	PROPN
admet-1037	234	18	yuan	yuan	PROPN
admet-1037	234	19	,	,	PUNCT
admet-1037	234	20	g.	g.	PROPN
admet-1037	234	21	zheng	zheng	PROPN
admet-1037	234	22	,	,	PUNCT
admet-1037	234	23	d.	d.	PROPN
admet-1037	234	24	zhou	zhou	PROPN
admet-1037	234	25	.	.	PUNCT
admet-1037	235	1	assays	assay	NOUN
admet-1037	235	2	and	and	CCONJ
admet-1037	235	3	technologies	technology	NOUN
admet-1037	235	4	for	for	ADP
admet-1037	235	5	developing	develop	VERB
admet-1037	235	6	proteolysis	proteolysis	NOUN
admet-1037	235	7	targeting	target	VERB
admet-1037	235	8	chimera	chimera	NOUN
admet-1037	235	9	degraders	degrader	NOUN
admet-1037	235	10	.	.	PUNCT
admet-1037	236	1	future	future	ADJ
admet-1037	236	2	medicinal	medicinal	ADJ
admet-1037	236	3	chemistry	chemistry	NOUN
admet-1037	236	4	12	12	NUM
admet-1037	236	5	(	(	PUNCT
admet-1037	236	6	2020	2020	NUM
admet-1037	236	7	)	)	PUNCT
admet-1037	236	8	1155	1155	NUM
admet-1037	236	9	-	-	SYM
admet-1037	236	10	1179	1179	NUM
admet-1037	236	11	.	.	PUNCT
admet-1037	237	1	https://doi.org/10.4155/fmc-2020-0073	https://doi.org/10.4155/fmc-2020-0073	NOUN
admet-1037	237	2	.	.	PUNCT
admet-1037	238	1	[	[	X
admet-1037	238	2	6	6	NUM
admet-1037	238	3	]	]	PUNCT
admet-1037	238	4	s.	s.	PROPN
admet-1037	238	5	ramachandran	ramachandran	PROPN
admet-1037	238	6	,	,	PUNCT
admet-1037	238	7	a.	a.	PROPN
admet-1037	238	8	ciulli	ciulli	PROPN
admet-1037	238	9	.	.	PUNCT
admet-1037	239	1	building	build	VERB
admet-1037	239	2	ubiquitination	ubiquitination	NOUN
admet-1037	239	3	machineries	machinery	NOUN
admet-1037	239	4	:	:	PUNCT
admet-1037	239	5	e3	e3	NOUN
admet-1037	239	6	ligase	ligase	NOUN
admet-1037	239	7	multi	multi	ADJ
admet-1037	239	8	-	-	ADJ
admet-1037	239	9	subunit	subunit	ADJ
admet-1037	239	10	assembly	assembly	NOUN
admet-1037	239	11	and	and	CCONJ
admet-1037	239	12	substrate	substrate	NOUN
admet-1037	239	13	targeting	target	VERB
admet-1037	239	14	by	by	ADP
admet-1037	239	15	protacs	protac	NOUN
admet-1037	239	16	and	and	CCONJ
admet-1037	239	17	molecular	molecular	ADJ
admet-1037	239	18	glues	glue	NOUN
admet-1037	239	19	.	.	PUNCT
admet-1037	240	1	current	current	ADJ
admet-1037	240	2	opinion	opinion	NOUN
admet-1037	240	3	in	in	ADP
admet-1037	240	4	structural	structural	ADJ
admet-1037	240	5	biology	biology	NOUN
admet-1037	240	6	67	67	NUM
admet-1037	240	7	(	(	PUNCT
admet-1037	240	8	2021	2021	NUM
admet-1037	240	9	)	)	PUNCT
admet-1037	240	10	110–119	110–119	NUM
admet-1037	240	11	.	.	PUNCT
admet-1037	241	1	https://doi.org/10.1016/j.sbi.2020.10.009	https://doi.org/10.1016/j.sbi.2020.10.009	NOUN
admet-1037	241	2	.	.	PUNCT
admet-1037	242	1	[	[	X
admet-1037	242	2	7	7	X
admet-1037	242	3	]	]	X
admet-1037	242	4	k.m	k.m	PROPN
admet-1037	242	5	.	.	PROPN
admet-1037	242	6	sakamoto	sakamoto	PROPN
admet-1037	242	7	,	,	PUNCT
admet-1037	242	8	k.b	k.b	PROPN
admet-1037	242	9	.	.	PUNCT
admet-1037	242	10	kim	kim	PROPN
admet-1037	242	11	,	,	PUNCT
admet-1037	242	12	a.	a.	PROPN
admet-1037	242	13	kumagai	kumagai	PROPN
admet-1037	242	14	,	,	PUNCT
admet-1037	242	15	f.	f.	PROPN
admet-1037	242	16	mercurio	mercurio	PROPN
admet-1037	242	17	,	,	PUNCT
admet-1037	242	18	c.m	c.m	PROPN
admet-1037	242	19	.	.	PROPN
admet-1037	242	20	crews	crew	NOUN
admet-1037	242	21	,	,	PUNCT
admet-1037	242	22	r.j	r.j	PROPN
admet-1037	242	23	.	.	PROPN
admet-1037	242	24	deshaies	deshaie	NOUN
admet-1037	242	25	.	.	PUNCT
admet-1037	243	1	protacs	protac	NOUN
admet-1037	243	2	:	:	PUNCT
admet-1037	243	3	chimeric	chimeric	ADJ
admet-1037	243	4	molecules	molecule	NOUN
admet-1037	243	5	that	that	PRON
admet-1037	243	6	target	target	VERB
admet-1037	243	7	proteins	protein	NOUN
admet-1037	243	8	to	to	ADP
admet-1037	243	9	the	the	DET
admet-1037	243	10	skp1	skp1	PROPN
admet-1037	243	11	-	-	PUNCT
admet-1037	243	12	cullin	cullin	PROPN
admet-1037	243	13	-	-	PUNCT
admet-1037	243	14	f	f	PROPN
admet-1037	243	15	box	box	PROPN
admet-1037	243	16	complex	complex	NOUN
admet-1037	243	17	for	for	ADP
admet-1037	243	18	ubiquitination	ubiquitination	NOUN
admet-1037	243	19	and	and	CCONJ
admet-1037	243	20	degradation	degradation	NOUN
admet-1037	243	21	.	.	PUNCT
admet-1037	244	1	proceedings	proceeding	NOUN
admet-1037	244	2	of	of	ADP
admet-1037	244	3	the	the	DET
admet-1037	244	4	national	national	PROPN
admet-1037	244	5	academy	academy	PROPN
admet-1037	244	6	of	of	ADP
admet-1037	244	7	sciences	sciences	PROPN
admet-1037	244	8	98	98	NUM
admet-1037	244	9	(	(	PUNCT
admet-1037	244	10	2001	2001	NUM
admet-1037	244	11	)	)	PUNCT
admet-1037	244	12	8554–8559	8554–8559	NUM
admet-1037	244	13	.	.	PUNCT
admet-1037	245	1	https://doi.org/10.1073/pnas.141230798	https://doi.org/10.1073/pnas.141230798	X
admet-1037	245	2	.	.	PUNCT
admet-1037	246	1	[	[	X
admet-1037	246	2	8	8	NUM
admet-1037	246	3	]	]	PUNCT
admet-1037	246	4	a.	a.	NOUN
admet-1037	246	5	mullard	mullard	PROPN
admet-1037	246	6	.	.	PUNCT
admet-1037	247	1	targeted	target	VERB
admet-1037	247	2	protein	protein	NOUN
admet-1037	247	3	degraders	degrader	NOUN
admet-1037	247	4	crowd	crowd	VERB
admet-1037	247	5	into	into	ADP
admet-1037	247	6	the	the	DET
admet-1037	247	7	clinic	clinic	NOUN
admet-1037	247	8	.	.	PUNCT
admet-1037	248	1	nature	nature	NOUN
admet-1037	248	2	reviews	review	VERB
admet-1037	248	3	drug	drug	NOUN
admet-1037	248	4	discovery	discovery	NOUN
admet-1037	248	5	20	20	NUM
admet-1037	248	6	(	(	PUNCT
admet-1037	248	7	2021	2021	NUM
admet-1037	248	8	)	)	PUNCT
admet-1037	248	9	247	247	NUM
admet-1037	248	10	-	-	SYM
admet-1037	248	11	250	250	NUM
admet-1037	248	12	.	.	PUNCT
admet-1037	249	1	https://doi.org/10.1038/d41573-021-00052-4	https://doi.org/10.1038/d41573-021-00052-4	NUM
admet-1037	249	2	.	.	PUNCT
admet-1037	250	1	[	[	X
admet-1037	250	2	9	9	NUM
admet-1037	250	3	]	]	X
admet-1037	250	4	c.a	c.a	PROPN
admet-1037	250	5	.	.	PROPN
admet-1037	250	6	lipinski	lipinski	PROPN
admet-1037	250	7	,	,	PUNCT
admet-1037	250	8	f.	f.	PROPN
admet-1037	250	9	lombardo	lombardo	PROPN
admet-1037	250	10	,	,	PUNCT
admet-1037	250	11	b.w	b.w	PROPN
admet-1037	250	12	.	.	PROPN
admet-1037	250	13	dominy	dominy	PROPN
admet-1037	250	14	,	,	PUNCT
admet-1037	250	15	p.j	p.j	PROPN
admet-1037	250	16	.	.	PROPN
admet-1037	250	17	feeney	feeney	PROPN
admet-1037	250	18	.	.	PUNCT
admet-1037	251	1	experimental	experimental	ADJ
admet-1037	251	2	and	and	CCONJ
admet-1037	251	3	computational	computational	ADJ
admet-1037	251	4	approaches	approach	NOUN
admet-1037	251	5	to	to	PART
admet-1037	251	6	estimate	estimate	VERB
admet-1037	251	7	solubility	solubility	NOUN
admet-1037	251	8	and	and	CCONJ
admet-1037	251	9	permeability	permeability	NOUN
admet-1037	251	10	in	in	ADP
admet-1037	251	11	drug	drug	NOUN
admet-1037	251	12	discovery	discovery	NOUN
admet-1037	251	13	and	and	CCONJ
admet-1037	251	14	development	development	NOUN
admet-1037	251	15	settings	setting	NOUN
admet-1037	251	16	.	.	PUNCT
admet-1037	252	1	advanced	advanced	ADJ
admet-1037	252	2	drug	drug	NOUN
admet-1037	252	3	delivery	delivery	NOUN
admet-1037	252	4	reviews	review	VERB
admet-1037	252	5	23	23	NUM
admet-1037	252	6	(	(	PUNCT
admet-1037	252	7	1997	1997	NUM
admet-1037	252	8	)	)	PUNCT
admet-1037	253	1	3–25	3–25	VERB
admet-1037	253	2	.	.	PUNCT
admet-1037	254	1	https://doi.org/10.1016/s0169-409x(96)00423-1	https://doi.org/10.1016/s0169-409x(96)00423-1	NOUN
admet-1037	254	2	.	.	PUNCT
admet-1037	255	1	[	[	X
admet-1037	255	2	10	10	NUM
admet-1037	255	3	]	]	X
admet-1037	255	4	d.f	d.f	PROPN
admet-1037	255	5	.	.	PROPN
admet-1037	255	6	veber	veber	PROPN
admet-1037	255	7	,	,	PUNCT
admet-1037	255	8	s.r	s.r	PROPN
admet-1037	255	9	.	.	PROPN
admet-1037	255	10	johnson	johnson	PROPN
admet-1037	255	11	,	,	PUNCT
admet-1037	255	12	h.-y	h.-y	NOUN
admet-1037	255	13	.	.	PUNCT
admet-1037	256	1	cheng	cheng	PROPN
admet-1037	256	2	,	,	PUNCT
admet-1037	256	3	b.r	b.r	PROPN
admet-1037	256	4	.	.	PROPN
admet-1037	256	5	smith	smith	PROPN
admet-1037	256	6	,	,	PUNCT
admet-1037	256	7	k.w	k.w	PROPN
admet-1037	256	8	.	.	PROPN
admet-1037	256	9	ward	ward	PROPN
admet-1037	256	10	,	,	PUNCT
admet-1037	256	11	k.d	k.d	PROPN
admet-1037	256	12	.	.	PROPN
admet-1037	256	13	kopple	kopple	PROPN
admet-1037	256	14	.	.	PUNCT
admet-1037	257	1	molecular	molecular	ADJ
admet-1037	257	2	properties	property	NOUN
admet-1037	257	3	that	that	PRON
admet-1037	257	4	influence	influence	VERB
admet-1037	257	5	the	the	DET
admet-1037	257	6	oral	oral	ADJ
admet-1037	257	7	bioavailability	bioavailability	NOUN
admet-1037	257	8	of	of	ADP
admet-1037	257	9	drug	drug	NOUN
admet-1037	257	10	candidates	candidate	NOUN
admet-1037	257	11	.	.	PUNCT
admet-1037	258	1	journal	journal	NOUN
admet-1037	258	2	of	of	ADP
admet-1037	258	3	medicinal	medicinal	ADJ
admet-1037	258	4	chemistry	chemistry	NOUN
admet-1037	258	5	45	45	NUM
admet-1037	258	6	(	(	PUNCT
admet-1037	258	7	2002	2002	NUM
admet-1037	258	8	)	)	PUNCT
admet-1037	258	9	2615	2615	NUM
admet-1037	258	10	–	–	PUNCT
admet-1037	258	11	2623	2623	NUM
admet-1037	258	12	.	.	PUNCT
admet-1037	259	1	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	NOUN
admet-1037	259	2	.	.	PUNCT
admet-1037	260	1	[	[	X
admet-1037	260	2	11	11	NUM
admet-1037	260	3	]	]	X
admet-1037	260	4	v.	v.	ADP
admet-1037	260	5	poongavanam	poongavanam	PROPN
admet-1037	260	6	,	,	PUNCT
admet-1037	260	7	b.c	b.c	PROPN
admet-1037	260	8	.	.	PROPN
admet-1037	260	9	doak	doak	PROPN
admet-1037	260	10	,	,	PUNCT
admet-1037	260	11	j.	j.	PROPN
admet-1037	260	12	kihlberg	kihlberg	PROPN
admet-1037	260	13	.	.	PUNCT
admet-1037	261	1	opportunities	opportunity	NOUN
admet-1037	261	2	and	and	CCONJ
admet-1037	261	3	guidelines	guideline	NOUN
admet-1037	261	4	for	for	ADP
admet-1037	261	5	discovery	discovery	NOUN
admet-1037	261	6	of	of	ADP
admet-1037	261	7	orally	orally	ADV
admet-1037	261	8	absorbed	absorb	VERB
admet-1037	261	9	drugs	drug	NOUN
admet-1037	261	10	in	in	ADP
admet-1037	261	11	beyond	beyond	ADP
admet-1037	261	12	rule	rule	NOUN
admet-1037	261	13	of	of	ADP
admet-1037	261	14	5	5	NUM
admet-1037	261	15	space	space	NOUN
admet-1037	261	16	.	.	PUNCT
admet-1037	262	1	current	current	ADJ
admet-1037	262	2	opinion	opinion	NOUN
admet-1037	262	3	in	in	ADP
admet-1037	262	4	chemical	chemical	ADJ
admet-1037	262	5	biology	biology	NOUN
admet-1037	262	6	44	44	NUM
admet-1037	262	7	(	(	PUNCT
admet-1037	262	8	2018	2018	NUM
admet-1037	262	9	)	)	PUNCT
admet-1037	262	10	23–29	23–29	NUM
admet-1037	262	11	.	.	PUNCT
admet-1037	263	1	https://doi.org/10.1016/j.cbpa.2018.05.010	https://doi.org/10.1016/j.cbpa.2018.05.010	NOUN
admet-1037	263	2	.	.	PUNCT
admet-1037	264	1	[	[	X
admet-1037	264	2	12	12	NUM
admet-1037	264	3	]	]	X
admet-1037	264	4	d.a	d.a	PROPN
admet-1037	264	5	.	.	PROPN
admet-1037	264	6	degoey	degoey	PROPN
admet-1037	264	7	,	,	PUNCT
admet-1037	264	8	h.-j	h.-j	PROPN
admet-1037	264	9	.	.	PUNCT
admet-1037	265	1	chen	chen	PROPN
admet-1037	265	2	,	,	PUNCT
admet-1037	265	3	p.b	p.b	PROPN
admet-1037	265	4	.	.	PROPN
admet-1037	265	5	cox	cox	PROPN
admet-1037	265	6	,	,	PUNCT
admet-1037	265	7	m.d	m.d	PROPN
admet-1037	265	8	.	.	PROPN
admet-1037	265	9	wendt	wendt	PROPN
admet-1037	265	10	.	.	PUNCT
admet-1037	266	1	beyond	beyond	ADP
admet-1037	266	2	the	the	DET
admet-1037	266	3	rule	rule	NOUN
admet-1037	266	4	of	of	ADP
admet-1037	266	5	5	5	NUM
admet-1037	266	6	:	:	PUNCT
admet-1037	266	7	lessons	lesson	NOUN
admet-1037	266	8	learned	learn	VERB
admet-1037	266	9	from	from	ADP
admet-1037	266	10	abbvie	abbvie	PROPN
admet-1037	266	11	’s	’s	PART
admet-1037	266	12	drugs	drug	NOUN
admet-1037	266	13	and	and	CCONJ
admet-1037	266	14	compound	compound	NOUN
admet-1037	266	15	collection	collection	NOUN
admet-1037	266	16	.	.	PUNCT
admet-1037	267	1	journal	journal	PROPN
admet-1037	267	2	of	of	ADP
admet-1037	267	3	medicinal	medicinal	ADJ
admet-1037	267	4	chemistry	chemistry	NOUN
admet-1037	267	5	61	61	NUM
admet-1037	267	6	(	(	PUNCT
admet-1037	267	7	2018	2018	NUM
admet-1037	267	8	)	)	PUNCT
admet-1037	267	9	2636–2651	2636–2651	NUM
admet-1037	267	10	.	.	PUNCT
admet-1037	268	1	https://doi.org/10.1021/acs.jmedchem.7b00717	https://doi.org/10.1021/acs.jmedchem.7b00717	ADJ
admet-1037	268	2	.	.	PUNCT
admet-1037	269	1	[	[	X
admet-1037	269	2	13	13	NUM
admet-1037	269	3	]	]	X
admet-1037	269	4	s.d	s.d	PROPN
admet-1037	269	5	.	.	PROPN
admet-1037	269	6	edmondson	edmondson	PROPN
admet-1037	269	7	,	,	PUNCT
admet-1037	269	8	b.	b.	PROPN
admet-1037	269	9	yang	yang	PROPN
admet-1037	269	10	,	,	PUNCT
admet-1037	269	11	c.	c.	PROPN
admet-1037	269	12	fallan	fallan	PROPN
admet-1037	269	13	.	.	PUNCT
admet-1037	270	1	proteolysis	proteolysis	NOUN
admet-1037	270	2	targeting	target	VERB
admet-1037	270	3	chimeras	chimera	NOUN
admet-1037	270	4	(	(	PUNCT
admet-1037	270	5	protacs	protac	NOUN
admet-1037	270	6	)	)	PUNCT
admet-1037	270	7	in	in	ADP
admet-1037	270	8	‘	'	PUNCT
admet-1037	270	9	beyond	beyond	ADP
admet-1037	270	10	rule	rule	NOUN
admet-1037	270	11	-	-	PUNCT
admet-1037	270	12	of	of	ADP
admet-1037	270	13	-	-	PUNCT
admet-1037	270	14	five	five	NUM
admet-1037	270	15	’	'	PUNCT
admet-1037	270	16	chemical	chemical	NOUN
admet-1037	270	17	space	space	NOUN
admet-1037	270	18	:	:	PUNCT
admet-1037	270	19	recent	recent	ADJ
admet-1037	270	20	progress	progress	NOUN
admet-1037	270	21	and	and	CCONJ
admet-1037	270	22	future	future	ADJ
admet-1037	270	23	challenges	challenge	NOUN
admet-1037	270	24	.	.	PUNCT
admet-1037	271	1	bioorganic	bioorganic	ADJ
admet-1037	271	2	and	and	CCONJ
admet-1037	271	3	medicinal	medicinal	ADJ
admet-1037	271	4	chemistry	chemistry	NOUN
admet-1037	271	5	letters	letter	NOUN
admet-1037	271	6	29	29	NUM
admet-1037	271	7	(	(	PUNCT
admet-1037	271	8	2019	2019	NUM
admet-1037	271	9	)	)	PUNCT
admet-1037	271	10	1555–1564	1555–1564	NUM
admet-1037	271	11	.	.	PUNCT
admet-1037	272	1	https://doi.org/10.1016/j.bmcl.2019.04.030	https://doi.org/10.1016/j.bmcl.2019.04.030	NOUN
admet-1037	272	2	.	.	PUNCT
admet-1037	273	1	[	[	X
admet-1037	273	2	14	14	NUM
admet-1037	273	3	]	]	X
admet-1037	273	4	h.j	h.j	PROPN
admet-1037	273	5	.	.	PROPN
admet-1037	273	6	maple	maple	PROPN
admet-1037	273	7	,	,	PUNCT
admet-1037	273	8	n.	n.	PROPN
admet-1037	273	9	clayden	clayden	PROPN
admet-1037	273	10	,	,	PUNCT
admet-1037	273	11	a.	a.	NOUN
admet-1037	273	12	baron	baron	NOUN
admet-1037	273	13	,	,	PUNCT
admet-1037	273	14	c.	c.	PROPN
admet-1037	273	15	stacey	stacey	PROPN
admet-1037	273	16	,	,	PUNCT
admet-1037	273	17	r.	r.	PROPN
admet-1037	273	18	felix	felix	PROPN
admet-1037	273	19	.	.	PUNCT
admet-1037	274	1	developing	develop	VERB
admet-1037	274	2	degraders	degrader	NOUN
admet-1037	274	3	:	:	PUNCT
admet-1037	274	4	principles	principle	NOUN
admet-1037	274	5	and	and	CCONJ
admet-1037	274	6	perspectives	perspective	NOUN
admet-1037	274	7	on	on	ADP
admet-1037	274	8	design	design	NOUN
admet-1037	274	9	and	and	CCONJ
admet-1037	274	10	chemical	chemical	NOUN
admet-1037	274	11	space	space	NOUN
admet-1037	274	12	.	.	PUNCT
admet-1037	275	1	medchemcomm	medchemcomm	NOUN
admet-1037	275	2	10	10	NUM
admet-1037	275	3	(	(	PUNCT
admet-1037	275	4	2019	2019	NUM
admet-1037	275	5	)	)	PUNCT
admet-1037	275	6	1659–1846	1659–1846	NUM
admet-1037	275	7	.	.	PUNCT
admet-1037	276	1	https://doi.org/10.1039/c9md00272c	https://doi.org/10.1039/c9md00272c	NOUN
admet-1037	276	2	.	.	PUNCT
admet-1037	277	1	[	[	X
admet-1037	277	2	15	15	NUM
admet-1037	277	3	]	]	X
admet-1037	277	4	g.	g.	NOUN
admet-1037	277	5	ermondi	ermondi	PROPN
admet-1037	277	6	,	,	PUNCT
admet-1037	277	7	d.	d.	PROPN
admet-1037	277	8	garcia	garcia	PROPN
admet-1037	277	9	jimenez	jimenez	PROPN
admet-1037	277	10	,	,	PUNCT
admet-1037	277	11	m.	m.	PROPN
admet-1037	277	12	rossi	rossi	PROPN
admet-1037	277	13	sebastiano	sebastiano	PROPN
admet-1037	277	14	,	,	PUNCT
admet-1037	277	15	g.	g.	PROPN
admet-1037	277	16	caron	caron	PROPN
admet-1037	277	17	.	.	PUNCT
admet-1037	278	1	rational	rational	ADJ
admet-1037	278	2	control	control	NOUN
admet-1037	278	3	of	of	ADP
admet-1037	278	4	molecular	molecular	ADJ
admet-1037	278	5	properties	property	NOUN
admet-1037	278	6	is	be	AUX
admet-1037	278	7	mandatory	mandatory	ADJ
admet-1037	278	8	to	to	PART
admet-1037	278	9	exploit	exploit	VERB
admet-1037	278	10	the	the	DET
admet-1037	278	11	potential	potential	NOUN
admet-1037	278	12	of	of	ADP
admet-1037	278	13	protacs	protac	NOUN
admet-1037	278	14	as	as	ADP
admet-1037	278	15	oral	oral	ADJ
admet-1037	278	16	drugs	drug	NOUN
admet-1037	278	17	.	.	PUNCT
admet-1037	279	1	acs	acs	PROPN
admet-1037	279	2	medicinal	medicinal	ADJ
admet-1037	279	3	chemistry	chemistry	NOUN
admet-1037	279	4	letters	letter	NOUN
admet-1037	279	5	12	12	NUM
admet-1037	279	6	(	(	PUNCT
admet-1037	279	7	2021	2021	NUM
admet-1037	279	8	)	)	PUNCT
admet-1037	279	9	1056–1060	1056–1060	NUM
admet-1037	279	10	.	.	PUNCT
admet-1037	280	1	https://doi.org/10.1021/acsmedchemlett.1c00298	https://doi.org/10.1021/acsmedchemlett.1c00298	NOUN
admet-1037	280	2	.	.	PUNCT
admet-1037	281	1	[	[	X
admet-1037	281	2	16	16	NUM
admet-1037	281	3	]	]	X
admet-1037	281	4	g.	g.	PROPN
admet-1037	281	5	weng	weng	PROPN
admet-1037	281	6	,	,	PUNCT
admet-1037	281	7	c.	c.	PROPN
admet-1037	281	8	shen	shen	PROPN
admet-1037	281	9	,	,	PUNCT
admet-1037	281	10	d.	d.	PROPN
admet-1037	281	11	cao	cao	PROPN
admet-1037	281	12	,	,	PUNCT
admet-1037	281	13	j.	j.	PROPN
admet-1037	281	14	gao	gao	PROPN
admet-1037	281	15	,	,	PUNCT
admet-1037	281	16	x.	x.	PROPN
admet-1037	281	17	dong	dong	PROPN
admet-1037	281	18	,	,	PUNCT
admet-1037	281	19	q.	q.	PROPN
admet-1037	281	20	he	he	PRON
admet-1037	281	21	,	,	PUNCT
admet-1037	281	22	b.	b.	PROPN
admet-1037	281	23	yang	yang	PROPN
admet-1037	281	24	,	,	PUNCT
admet-1037	281	25	d.	d.	PROPN
admet-1037	281	26	li	li	PROPN
admet-1037	281	27	,	,	PUNCT
admet-1037	281	28	j.	j.	PROPN
admet-1037	281	29	wu	wu	PROPN
admet-1037	281	30	,	,	PUNCT
admet-1037	281	31	t.	t.	PROPN
admet-1037	281	32	hou	hou	PROPN
admet-1037	281	33	.	.	PUNCT
admet-1037	282	1	protac	protac	ADJ
admet-1037	282	2	-	-	PUNCT
admet-1037	282	3	db	db	NOUN
admet-1037	282	4	:	:	PUNCT
admet-1037	282	5	an	an	DET
admet-1037	282	6	online	online	ADJ
admet-1037	282	7	database	database	NOUN
admet-1037	282	8	of	of	ADP
admet-1037	282	9	protacs	protac	NOUN
admet-1037	282	10	.	.	PUNCT
admet-1037	283	1	nucleic	nucleic	ADJ
admet-1037	283	2	acids	acid	NOUN
admet-1037	283	3	research	research	NOUN
admet-1037	283	4	49	49	NUM
admet-1037	283	5	(	(	PUNCT
admet-1037	283	6	2020	2020	NUM
admet-1037	283	7	)	)	PUNCT
admet-1037	283	8	d1381	d1381	PROPN
admet-1037	283	9	–	–	PUNCT
admet-1037	283	10	d1387	d1387	NOUN
admet-1037	283	11	.	.	PUNCT
admet-1037	284	1	https://doi.org/10.1093/nar/gkaa807	https://doi.org/10.1093/nar/gkaa807	PROPN
admet-1037	284	2	.	.	PUNCT
admet-1037	285	1	[	[	X
admet-1037	285	2	17	17	NUM
admet-1037	285	3	]	]	X
admet-1037	285	4	g.	g.	NOUN
admet-1037	285	5	ermondi	ermondi	PROPN
admet-1037	285	6	,	,	PUNCT
admet-1037	285	7	d.	d.	PROPN
admet-1037	285	8	garcia	garcia	PROPN
admet-1037	285	9	-	-	PUNCT
admet-1037	285	10	jimenez	jimenez	PROPN
admet-1037	285	11	,	,	PUNCT
admet-1037	285	12	g.	g.	PROPN
admet-1037	285	13	caron	caron	PROPN
admet-1037	285	14	.	.	PUNCT
admet-1037	285	15	protacs	protacs	PROPN
admet-1037	285	16	and	and	CCONJ
admet-1037	285	17	building	building	NOUN
admet-1037	285	18	blocks	block	NOUN
admet-1037	285	19	:	:	PUNCT
admet-1037	285	20	the	the	DET
admet-1037	285	21	2d	2d	NUM
admet-1037	285	22	chemical	chemical	NOUN
admet-1037	285	23	space	space	NOUN
admet-1037	285	24	in	in	ADP
admet-1037	285	25	very	very	ADV
admet-1037	285	26	early	early	ADJ
admet-1037	285	27	drug	drug	NOUN
admet-1037	285	28	discovery	discovery	NOUN
admet-1037	285	29	.	.	PUNCT
admet-1037	286	1	molecules	molecule	NOUN
admet-1037	286	2	26	26	NUM
admet-1037	286	3	(	(	PUNCT
admet-1037	286	4	2021	2021	NUM
admet-1037	286	5	)	)	PUNCT
admet-1037	286	6	672	672	NUM
admet-1037	286	7	.	.	PUNCT
admet-1037	286	8	https://doi.org/10.3390/molecules26030672	https://doi.org/10.3390/molecules26030672	PROPN
admet-1037	286	9	.	.	PUNCT
admet-1037	287	1	[	[	X
admet-1037	287	2	18	18	NUM
admet-1037	287	3	]	]	SYM
admet-1037	287	4	b.c	b.c	PROPN
admet-1037	287	5	.	.	PROPN
admet-1037	287	6	doak	doak	PROPN
admet-1037	287	7	,	,	PUNCT
admet-1037	287	8	b.	b.	PROPN
admet-1037	287	9	over	over	PROPN
admet-1037	287	10	,	,	PUNCT
admet-1037	287	11	f.	f.	PROPN
admet-1037	287	12	giordanetto	giordanetto	PROPN
admet-1037	287	13	,	,	PUNCT
admet-1037	287	14	j.	j.	PROPN
admet-1037	287	15	kihlberg	kihlberg	PROPN
admet-1037	287	16	.	.	PUNCT
admet-1037	288	1	oral	oral	ADJ
admet-1037	288	2	druggable	druggable	ADJ
admet-1037	288	3	space	space	NOUN
admet-1037	288	4	beyond	beyond	ADP
admet-1037	288	5	the	the	DET
admet-1037	288	6	rule	rule	NOUN
admet-1037	288	7	of	of	ADP
admet-1037	288	8	5	5	NUM
admet-1037	288	9	:	:	PUNCT
admet-1037	288	10	insights	insight	NOUN
admet-1037	288	11	from	from	ADP
admet-1037	288	12	drugs	drug	NOUN
admet-1037	288	13	and	and	CCONJ
admet-1037	288	14	clinical	clinical	ADJ
admet-1037	288	15	candidates	candidate	NOUN
admet-1037	288	16	.	.	PUNCT
admet-1037	289	1	chemistry	chemistry	NOUN
admet-1037	289	2	&	&	CCONJ
admet-1037	289	3	biology	biology	NOUN
admet-1037	289	4	21	21	NUM
admet-1037	289	5	(	(	PUNCT
admet-1037	289	6	2014	2014	NUM
admet-1037	289	7	)	)	PUNCT
admet-1037	289	8	1115–42	1115–42	NUM
admet-1037	289	9	.	.	PUNCT
admet-1037	290	1	https://doi.org/10.1016/j.chembiol.2014.08.013	https://doi.org/10.1016/j.chembiol.2014.08.013	X
admet-1037	290	2	.	.	PUNCT
admet-1037	291	1	[	[	X
admet-1037	291	2	19	19	NUM
admet-1037	291	3	]	]	X
admet-1037	291	4	d.	d.	PROPN
admet-1037	291	5	mendez	mendez	PROPN
admet-1037	291	6	,	,	PUNCT
admet-1037	291	7	a.	a.	NOUN
admet-1037	291	8	gaulton	gaulton	PROPN
admet-1037	291	9	,	,	PUNCT
admet-1037	291	10	a.p	a.p	PROPN
admet-1037	291	11	.	.	PROPN
admet-1037	291	12	bento	bento	PROPN
admet-1037	291	13	,	,	PUNCT
admet-1037	291	14	j.	j.	PROPN
admet-1037	291	15	chambers	chambers	PROPN
admet-1037	291	16	,	,	PUNCT
admet-1037	291	17	m.	m.	NOUN
admet-1037	291	18	de	de	PROPN
admet-1037	291	19	veij	veij	PROPN
admet-1037	291	20	,	,	PUNCT
admet-1037	291	21	e.	e.	PROPN
admet-1037	291	22	félix	félix	PROPN
admet-1037	291	23	,	,	PUNCT
admet-1037	291	24	m.p	m.p	PROPN
admet-1037	291	25	.	.	PROPN
admet-1037	291	26	magariños	magariños	PROPN
admet-1037	291	27	,	,	PUNCT
admet-1037	291	28	j.f	j.f	PROPN
admet-1037	291	29	.	.	PROPN
admet-1037	291	30	mosquera	mosquera	PROPN
admet-1037	291	31	,	,	PUNCT
admet-1037	291	32	p.	p.	PROPN
admet-1037	291	33	mutowo	mutowo	PROPN
admet-1037	291	34	,	,	PUNCT
admet-1037	291	35	m.	m.	NOUN
admet-1037	291	36	nowotka	nowotka	PROPN
admet-1037	291	37	,	,	PUNCT
admet-1037	291	38	m.	m.	NOUN
admet-1037	291	39	gordillo	gordillo	PROPN
admet-1037	291	40	-	-	PUNCT
admet-1037	291	41	marañón	marañón	PROPN
admet-1037	291	42	,	,	PUNCT
admet-1037	291	43	f.	f.	PROPN
admet-1037	291	44	hunter	hunter	PROPN
admet-1037	291	45	,	,	PUNCT
admet-1037	291	46	l.	l.	PROPN
admet-1037	291	47	junco	junco	PROPN
admet-1037	291	48	,	,	PUNCT
admet-1037	291	49	g.	g.	PROPN
admet-1037	291	50	mugumbate	mugumbate	PROPN
admet-1037	291	51	,	,	PUNCT
admet-1037	291	52	m.	m.	NOUN
admet-1037	291	53	rodriguezlopez	rodriguezlopez	PROPN
admet-1037	291	54	,	,	PUNCT
admet-1037	291	55	f.	f.	PROPN
admet-1037	291	56	atkinson	atkinson	PROPN
admet-1037	291	57	,	,	PUNCT
admet-1037	291	58	n.	n.	PROPN
admet-1037	291	59	bosc	bosc	PROPN
admet-1037	291	60	,	,	PUNCT
admet-1037	291	61	c.j	c.j	PROPN
admet-1037	291	62	.	.	PROPN
admet-1037	291	63	radoux	radoux	PROPN
admet-1037	291	64	,	,	PUNCT
admet-1037	291	65	a.	a.	PROPN
admet-1037	291	66	segura	segura	PROPN
admet-1037	291	67	-	-	PUNCT
admet-1037	291	68	cabrera	cabrera	PROPN
admet-1037	291	69	,	,	PUNCT
admet-1037	291	70	a.	a.	PROPN
admet-1037	291	71	hersey	hersey	PROPN
admet-1037	291	72	,	,	PUNCT
admet-1037	291	73	a.r	a.r	PROPN
admet-1037	291	74	.	.	PROPN
admet-1037	291	75	leach	leach	NOUN
admet-1037	291	76	.	.	PUNCT
admet-1037	292	1	chembl	chembl	NOUN
admet-1037	292	2	:	:	PUNCT
admet-1037	292	3	towards	towards	ADP
admet-1037	292	4	direct	direct	ADJ
admet-1037	292	5	deposition	deposition	NOUN
admet-1037	292	6	of	of	ADP
admet-1037	292	7	bioassay	bioassay	NOUN
admet-1037	292	8	data	datum	NOUN
admet-1037	292	9	.	.	PUNCT
admet-1037	293	1	nucleic	nucleic	ADJ
admet-1037	293	2	acids	acid	NOUN
admet-1037	293	3	research	research	NOUN
admet-1037	293	4	47	47	NUM
admet-1037	293	5	(	(	PUNCT
admet-1037	293	6	2019	2019	NUM
admet-1037	293	7	)	)	PUNCT
admet-1037	293	8	d930	d930	PROPN
admet-1037	293	9	–	–	PUNCT
admet-1037	293	10	d940	d940	PROPN
admet-1037	293	11	.	.	PUNCT
admet-1037	294	1	https://doi.org/10.1093/nar/gky1075	https://doi.org/10.1093/nar/gky1075	PROPN
admet-1037	294	2	.	.	PUNCT
admet-1037	295	1	[	[	X
admet-1037	295	2	20	20	NUM
admet-1037	295	3	]	]	X
admet-1037	295	4	m.k	m.k	PROPN
admet-1037	295	5	.	.	PROPN
admet-1037	295	6	gilson	gilson	PROPN
admet-1037	295	7	,	,	PUNCT
admet-1037	295	8	t.	t.	PROPN
admet-1037	295	9	liu	liu	PROPN
admet-1037	295	10	,	,	PUNCT
admet-1037	295	11	m.	m.	PROPN
admet-1037	295	12	baitaluk	baitaluk	PROPN
admet-1037	295	13	,	,	PUNCT
admet-1037	295	14	g.	g.	PROPN
admet-1037	295	15	nicola	nicola	PROPN
admet-1037	295	16	,	,	PUNCT
admet-1037	295	17	l.	l.	PROPN
admet-1037	295	18	hwang	hwang	PROPN
admet-1037	295	19	,	,	PUNCT
admet-1037	295	20	j.	j.	PROPN
admet-1037	295	21	chong	chong	PROPN
admet-1037	295	22	.	.	PUNCT
admet-1037	295	23	bindingdb	bindingdb	PROPN
admet-1037	295	24	in	in	ADP
admet-1037	295	25	2015	2015	NUM
admet-1037	295	26	:	:	PUNCT
admet-1037	295	27	a	a	DET
admet-1037	295	28	public	public	ADJ
admet-1037	295	29	database	database	NOUN
admet-1037	295	30	for	for	ADP
admet-1037	295	31	medicinal	medicinal	ADJ
admet-1037	295	32	chemistry	chemistry	NOUN
admet-1037	295	33	,	,	PUNCT
admet-1037	295	34	computational	computational	ADJ
admet-1037	295	35	chemistry	chemistry	NOUN
admet-1037	295	36	and	and	CCONJ
admet-1037	295	37	systems	system	NOUN
admet-1037	295	38	pharmacology	pharmacology	NOUN
admet-1037	295	39	.	.	PUNCT
admet-1037	296	1	nucleic	nucleic	ADJ
admet-1037	296	2	acids	acid	NOUN
admet-1037	296	3	research	research	NOUN
admet-1037	296	4	44	44	NUM
admet-1037	296	5	(	(	PUNCT
admet-1037	296	6	2016	2016	NUM
admet-1037	296	7	)	)	PUNCT
admet-1037	296	8	d1045	d1045	PROPN
admet-1037	296	9	–	–	PUNCT
admet-1037	296	10	d1053	d1053	ADJ
admet-1037	296	11	.	.	PUNCT
admet-1037	297	1	https://doi.org/10.1093/nar/gkv1072	https://doi.org/10.1093/nar/gkv1072	NOUN
admet-1037	297	2	.	.	PUNCT
admet-1037	298	1	http://dx.doi.org/10.5599/admet.1037	http://dx.doi.org/10.5599/admet.1037	X
admet-1037	298	2	https://doi.org/10.4155/fmc-2020-0073	https://doi.org/10.4155/fmc-2020-0073	PROPN
admet-1037	298	3	https://doi.org/10.4155/fmc-2020-0073	https://doi.org/10.4155/fmc-2020-0073	PROPN
admet-1037	298	4	https://doi.org/10.1016/j.sbi.2020.10.009	https://doi.org/10.1016/j.sbi.2020.10.009	PROPN
admet-1037	298	5	https://doi.org/10.1073/pnas.141230798	https://doi.org/10.1073/pnas.141230798	VERB
admet-1037	298	6	https://doi.org/10.1073/pnas.141230798	https://doi.org/10.1073/pnas.141230798	PROPN
admet-1037	298	7	https://doi.org/10.1038/d41573-021-00052-4	https://doi.org/10.1038/d41573-021-00052-4	NUM
admet-1037	298	8	https://doi.org/10.1016/s0169-409x(96)00423-1	https://doi.org/10.1016/s0169-409x(96)00423-1	NOUN
admet-1037	298	9	https://doi.org/10.1021/jm020017n	https://doi.org/10.1021/jm020017n	NOUN
admet-1037	298	10	https://doi.org/10.1016/j.cbpa.2018.05.010	https://doi.org/10.1016/j.cbpa.2018.05.010	NOUN
admet-1037	298	11	https://doi.org/10.1021/acs.jmedchem.7b00717	https://doi.org/10.1021/acs.jmedchem.7b00717	PRON
admet-1037	298	12	https://doi.org/10.1016/j.bmcl.2019.04.030	https://doi.org/10.1016/j.bmcl.2019.04.030	NOUN
admet-1037	298	13	https://doi.org/10.1039/c9md00272c	https://doi.org/10.1039/c9md00272c	SYM
admet-1037	298	14	https://doi.org/10.1039/c9md00272c	https://doi.org/10.1039/c9md00272c	NUM
admet-1037	298	15	https://doi.org/10.1021/acsmedchemlett.1c00298	https://doi.org/10.1021/acsmedchemlett.1c00298	NOUN
admet-1037	298	16	https://doi.org/10.1093/nar/gkaa807	https://doi.org/10.1093/nar/gkaa807	ADJ
admet-1037	298	17	https://doi.org/10.1093/nar/gkaa807	https://doi.org/10.1093/nar/gkaa807	PUNCT
admet-1037	298	18	https://doi.org/10.3390/molecules26030672	https://doi.org/10.3390/molecules26030672	VERB
admet-1037	298	19	https://doi.org/10.1016/j.chembiol.2014.08.013	https://doi.org/10.1016/j.chembiol.2014.08.013	NUM
admet-1037	298	20	https://doi.org/10.1016/j.chembiol.2014.08.013	https://doi.org/10.1016/j.chembiol.2014.08.013	NUM
admet-1037	298	21	https://doi.org/10.1093/nar/gky1075	https://doi.org/10.1093/nar/gky1075	ADJ
admet-1037	298	22	https://doi.org/10.1093/nar/gky1075	https://doi.org/10.1093/nar/gky1075	ADJ
admet-1037	298	23	https://doi.org/10.1093/nar/gkv1072	https://doi.org/10.1093/nar/gkv1072	NOUN
admet-1037	298	24	g.	g.	NOUN
admet-1037	298	25	ermondi	ermondi	PROPN
admet-1037	298	26	et	et	PROPN
admet-1037	298	27	al	al	PROPN
admet-1037	298	28	.	.	PROPN
admet-1037	298	29	admet	admet	PROPN
admet-1037	298	30	&	&	CCONJ
admet-1037	298	31	dmpk	dmpk	PROPN
admet-1037	298	32	9(4	9(4	PROPN
admet-1037	298	33	)	)	PUNCT
admet-1037	298	34	(	(	PUNCT
admet-1037	298	35	2021	2021	NUM
admet-1037	298	36	)	)	PUNCT
admet-1037	298	37	243	243	NUM
admet-1037	298	38	-	-	SYM
admet-1037	298	39	254	254	NUM
admet-1037	298	40	254	254	NUM
admet-1037	298	41	[	[	SYM
admet-1037	298	42	21	21	NUM
admet-1037	298	43	]	]	X
admet-1037	298	44	i.	i.	PROPN
admet-1037	298	45	v.	v.	PROPN
admet-1037	298	46	tetko	tetko	PROPN
admet-1037	298	47	,	,	PUNCT
admet-1037	298	48	v.y	v.y	PROPN
admet-1037	298	49	.	.	PROPN
admet-1037	298	50	tanchuk	tanchuk	PROPN
admet-1037	298	51	.	.	PUNCT
admet-1037	299	1	application	application	NOUN
admet-1037	299	2	of	of	ADP
admet-1037	299	3	associative	associative	ADJ
admet-1037	299	4	neural	neural	ADJ
admet-1037	299	5	networks	network	NOUN
admet-1037	299	6	for	for	ADP
admet-1037	299	7	prediction	prediction	NOUN
admet-1037	299	8	of	of	ADP
admet-1037	299	9	lipophilicity	lipophilicity	NOUN
admet-1037	299	10	in	in	ADP
admet-1037	299	11	alogps	alogps	PROPN
admet-1037	299	12	2.1	2.1	NUM
admet-1037	299	13	program	program	NOUN
admet-1037	299	14	.	.	PUNCT
admet-1037	300	1	journal	journal	PROPN
admet-1037	300	2	of	of	ADP
admet-1037	300	3	chemical	chemical	ADJ
admet-1037	300	4	information	information	NOUN
admet-1037	300	5	and	and	CCONJ
admet-1037	300	6	computer	computer	NOUN
admet-1037	300	7	sciences	science	NOUN
admet-1037	300	8	42	42	NUM
admet-1037	300	9	(	(	PUNCT
admet-1037	300	10	2002	2002	NUM
admet-1037	300	11	)	)	PUNCT
admet-1037	300	12	1136–1145	1136–1145	NUM
admet-1037	300	13	.	.	PUNCT
admet-1037	301	1	https://doi.org/10.1021/ci025515j	https://doi.org/10.1021/ci025515j	PROPN
admet-1037	301	2	.	.	PUNCT
admet-1037	302	1	[	[	X
admet-1037	302	2	22	22	NUM
admet-1037	302	3	]	]	PUNCT
admet-1037	302	4	z.	z.	PROPN
admet-1037	302	5	ma	ma	PROPN
admet-1037	302	6	,	,	PUNCT
admet-1037	302	7	y.	y.	PROPN
admet-1037	302	8	ji	ji	PROPN
admet-1037	302	9	,	,	PUNCT
admet-1037	302	10	y.	y.	PROPN
admet-1037	302	11	yu	yu	PROPN
admet-1037	302	12	,	,	PUNCT
admet-1037	302	13	d.	d.	PROPN
admet-1037	302	14	liang	liang	PROPN
admet-1037	302	15	.	.	PUNCT
admet-1037	303	1	specific	specific	ADJ
admet-1037	303	2	non	non	ADJ
admet-1037	303	3	-	-	ADJ
admet-1037	303	4	genetic	genetic	ADJ
admet-1037	303	5	iap	iap	PROPN
admet-1037	303	6	-	-	PUNCT
admet-1037	303	7	based	base	VERB
admet-1037	303	8	protein	protein	NOUN
admet-1037	303	9	erasers	eraser	NOUN
admet-1037	303	10	(	(	PUNCT
admet-1037	303	11	snipers	sniper	NOUN
admet-1037	303	12	)	)	PUNCT
admet-1037	303	13	as	as	ADP
admet-1037	303	14	a	a	DET
admet-1037	303	15	potential	potential	ADJ
admet-1037	303	16	therapeutic	therapeutic	ADJ
admet-1037	303	17	strategy	strategy	NOUN
admet-1037	303	18	.	.	PUNCT
admet-1037	304	1	european	european	ADJ
admet-1037	304	2	journal	journal	PROPN
admet-1037	304	3	of	of	ADP
admet-1037	304	4	medicinal	medicinal	ADJ
admet-1037	304	5	chemistry	chemistry	NOUN
admet-1037	304	6	216	216	NUM
admet-1037	304	7	(	(	PUNCT
admet-1037	304	8	2021	2021	NUM
admet-1037	304	9	)	)	PUNCT
admet-1037	304	10	113247	113247	NUM
admet-1037	304	11	.	.	PUNCT
admet-1037	305	1	https://doi.org/10.1016/j.ejmech.2021.113247	https://doi.org/10.1016/j.ejmech.2021.113247	NOUN
admet-1037	305	2	.	.	PUNCT
admet-1037	306	1	[	[	X
admet-1037	306	2	23	23	NUM
admet-1037	306	3	]	]	PUNCT
admet-1037	306	4	a.-d	a.-d	PROPN
admet-1037	306	5	.	.	PUNCT
admet-1037	307	1	gorse	gorse	NOUN
admet-1037	307	2	.	.	PUNCT
admet-1037	308	1	diversity	diversity	NOUN
admet-1037	308	2	in	in	ADP
admet-1037	308	3	medicinal	medicinal	ADJ
admet-1037	308	4	chemistry	chemistry	NOUN
admet-1037	308	5	space	space	NOUN
admet-1037	308	6	.	.	PUNCT
admet-1037	309	1	current	current	ADJ
admet-1037	309	2	topics	topic	NOUN
admet-1037	309	3	in	in	ADP
admet-1037	309	4	medicinal	medicinal	ADJ
admet-1037	309	5	chemistry	chemistry	NOUN
admet-1037	309	6	6	6	NUM
admet-1037	309	7	(	(	PUNCT
admet-1037	309	8	2006	2006	NUM
admet-1037	309	9	)	)	PUNCT
admet-1037	309	10	3–18	3–18	PROPN
admet-1037	309	11	.	.	PUNCT
admet-1037	310	1	https://doi.org/10.2174/156802606775193310	https://doi.org/10.2174/156802606775193310	PROPN
admet-1037	310	2	.	.	PUNCT
admet-1037	311	1	[	[	X
admet-1037	311	2	24	24	NUM
admet-1037	311	3	]	]	X
admet-1037	311	4	v.	v.	CCONJ
admet-1037	311	5	poongavanam	poongavanam	PROPN
admet-1037	311	6	,	,	PUNCT
admet-1037	311	7	e.	e.	PROPN
admet-1037	311	8	danelius	danelius	PROPN
admet-1037	311	9	,	,	PUNCT
admet-1037	311	10	s.	s.	PROPN
admet-1037	311	11	peintner	peintner	PROPN
admet-1037	311	12	,	,	PUNCT
admet-1037	311	13	l.	l.	PROPN
admet-1037	311	14	alcaraz	alcaraz	PROPN
admet-1037	311	15	,	,	PUNCT
admet-1037	311	16	g.	g.	PROPN
admet-1037	311	17	caron	caron	PROPN
admet-1037	311	18	,	,	PUNCT
admet-1037	311	19	m.d	m.d	PROPN
admet-1037	311	20	.	.	PROPN
admet-1037	311	21	cummings	cummings	PROPN
admet-1037	311	22	,	,	PUNCT
admet-1037	311	23	s.	s.	PROPN
admet-1037	311	24	wlodek	wlodek	PROPN
admet-1037	311	25	,	,	PUNCT
admet-1037	311	26	m.	m.	NOUN
admet-1037	311	27	erdelyi	erdelyi	NOUN
admet-1037	311	28	,	,	PUNCT
admet-1037	311	29	p.c.d	p.c.d	NOUN
admet-1037	311	30	.	.	PUNCT
admet-1037	312	1	hawkins	hawkins	PROPN
admet-1037	312	2	,	,	PUNCT
admet-1037	312	3	g.	g.	PROPN
admet-1037	312	4	ermondi	ermondi	PROPN
admet-1037	312	5	,	,	PUNCT
admet-1037	312	6	j.	j.	PROPN
admet-1037	312	7	kihlberg	kihlberg	PROPN
admet-1037	312	8	.	.	PUNCT
admet-1037	313	1	conformational	conformational	ADJ
admet-1037	313	2	sampling	sampling	NOUN
admet-1037	313	3	of	of	ADP
admet-1037	313	4	macrocyclic	macrocyclic	ADJ
admet-1037	313	5	drugs	drug	NOUN
admet-1037	313	6	in	in	ADP
admet-1037	313	7	different	different	ADJ
admet-1037	313	8	environments	environment	NOUN
admet-1037	313	9	:	:	PUNCT
admet-1037	313	10	can	can	AUX
admet-1037	313	11	we	we	PRON
admet-1037	313	12	find	find	VERB
admet-1037	313	13	the	the	DET
admet-1037	313	14	relevant	relevant	ADJ
admet-1037	313	15	conformations	conformation	NOUN
admet-1037	313	16	?	?	PUNCT
admet-1037	314	1	acs	acs	PROPN
admet-1037	314	2	omega	omega	NOUN
admet-1037	314	3	3	3	NUM
admet-1037	314	4	(	(	PUNCT
admet-1037	314	5	2018	2018	NUM
admet-1037	314	6	)	)	PUNCT
admet-1037	314	7	11742	11742	NUM
admet-1037	314	8	–	–	PUNCT
admet-1037	314	9	11757	11757	NUM
admet-1037	314	10	.	.	PUNCT
admet-1037	315	1	https://doi.org/10.1021/acsomega.8b01379	https://doi.org/10.1021/acsomega.8b01379	PROPN
admet-1037	315	2	.	.	PUNCT
admet-1037	316	1	[	[	X
admet-1037	316	2	25	25	NUM
admet-1037	316	3	]	]	X
admet-1037	316	4	g.	g.	NOUN
admet-1037	316	5	ermondi	ermondi	PROPN
admet-1037	316	6	,	,	PUNCT
admet-1037	316	7	m.	m.	NOUN
admet-1037	316	8	vallaro	vallaro	NOUN
admet-1037	316	9	,	,	PUNCT
admet-1037	316	10	g.	g.	PROPN
admet-1037	316	11	caron	caron	PROPN
admet-1037	316	12	.	.	PROPN
admet-1037	317	1	degraders	degrader	VERB
admet-1037	317	2	early	early	ADJ
admet-1037	317	3	developability	developability	NOUN
admet-1037	317	4	assessment	assessment	NOUN
admet-1037	317	5	:	:	PUNCT
admet-1037	317	6	face	face	NOUN
admet-1037	317	7	-	-	PUNCT
admet-1037	317	8	to	to	ADP
admet-1037	317	9	-	-	PUNCT
admet-1037	317	10	face	face	NOUN
admet-1037	317	11	with	with	ADP
admet-1037	317	12	molecular	molecular	ADJ
admet-1037	317	13	properties	property	NOUN
admet-1037	317	14	.	.	PUNCT
admet-1037	318	1	drug	drug	NOUN
admet-1037	318	2	discovery	discovery	PROPN
admet-1037	318	3	today	today	NOUN
admet-1037	318	4	25	25	NUM
admet-1037	318	5	(	(	PUNCT
admet-1037	318	6	2020	2020	NUM
admet-1037	318	7	)	)	PUNCT
admet-1037	318	8	1585–1591	1585–1591	NUM
admet-1037	318	9	.	.	PUNCT
admet-1037	319	1	https://doi.org/10.1016/j.drudis.2020.06.015	https://doi.org/10.1016/j.drudis.2020.06.015	PROPN
admet-1037	319	2	.	.	PUNCT
admet-1037	320	1	[	[	X
admet-1037	320	2	26	26	NUM
admet-1037	320	3	]	]	PUNCT
admet-1037	320	4	a.	a.	NOUN
admet-1037	320	5	whitty	whitty	PROPN
admet-1037	320	6	,	,	PUNCT
admet-1037	320	7	m.	m.	PROPN
admet-1037	320	8	zhong	zhong	PROPN
admet-1037	320	9	,	,	PUNCT
admet-1037	320	10	l.	l.	PROPN
admet-1037	320	11	viarengo	viarengo	PROPN
admet-1037	320	12	,	,	PUNCT
admet-1037	320	13	d.	d.	PROPN
admet-1037	320	14	beglov	beglov	PROPN
admet-1037	320	15	,	,	PUNCT
admet-1037	320	16	d.r	d.r	PROPN
admet-1037	320	17	.	.	PROPN
admet-1037	320	18	hall	hall	PROPN
admet-1037	320	19	,	,	PUNCT
admet-1037	320	20	s.	s.	PROPN
admet-1037	320	21	vajda	vajda	PROPN
admet-1037	320	22	.	.	PUNCT
admet-1037	321	1	quantifying	quantify	VERB
admet-1037	321	2	the	the	DET
admet-1037	321	3	chameleonic	chameleonic	ADJ
admet-1037	321	4	properties	property	NOUN
admet-1037	321	5	of	of	ADP
admet-1037	321	6	macrocycles	macrocycle	NOUN
admet-1037	321	7	and	and	CCONJ
admet-1037	321	8	other	other	ADJ
admet-1037	321	9	high	high	ADJ
admet-1037	321	10	-	-	PUNCT
admet-1037	321	11	molecular	molecular	ADJ
admet-1037	321	12	-	-	PUNCT
admet-1037	321	13	weight	weight	NOUN
admet-1037	321	14	drugs	drug	NOUN
admet-1037	321	15	.	.	PUNCT
admet-1037	322	1	drug	drug	NOUN
admet-1037	322	2	discovery	discovery	PROPN
admet-1037	322	3	today	today	NOUN
admet-1037	322	4	21	21	NUM
admet-1037	322	5	(	(	PUNCT
admet-1037	322	6	2016	2016	NUM
admet-1037	322	7	)	)	PUNCT
admet-1037	323	1	712–717	712–717	NUM
admet-1037	323	2	.	.	PUNCT
admet-1037	324	1	https://doi.org/10.1016/j.drudis.2016.02.005	https://doi.org/10.1016/j.drudis.2016.02.005	VERB
admet-1037	324	2	.	.	PUNCT
admet-1037	325	1	[	[	X
admet-1037	325	2	27	27	NUM
admet-1037	325	3	]	]	PUNCT
admet-1037	325	4	m.	m.	NOUN
admet-1037	325	5	rossi	rossi	PROPN
admet-1037	325	6	sebastiano	sebastiano	PROPN
admet-1037	325	7	,	,	PUNCT
admet-1037	325	8	b.c	b.c	PROPN
admet-1037	325	9	.	.	PROPN
admet-1037	325	10	doak	doak	PROPN
admet-1037	325	11	,	,	PUNCT
admet-1037	325	12	m.	m.	NOUN
admet-1037	325	13	backlund	backlund	PROPN
admet-1037	325	14	,	,	PUNCT
admet-1037	325	15	v.	v.	ADP
admet-1037	325	16	poongavanam	poongavanam	PROPN
admet-1037	325	17	,	,	PUNCT
admet-1037	325	18	b.	b.	PROPN
admet-1037	325	19	over	over	PROPN
admet-1037	325	20	,	,	PUNCT
admet-1037	325	21	g.	g.	PROPN
admet-1037	325	22	ermondi	ermondi	PROPN
admet-1037	325	23	,	,	PUNCT
admet-1037	325	24	g.	g.	PROPN
admet-1037	325	25	caron	caron	PROPN
admet-1037	325	26	,	,	PUNCT
admet-1037	325	27	p.	p.	PROPN
admet-1037	325	28	matsson	matsson	PROPN
admet-1037	325	29	,	,	PUNCT
admet-1037	325	30	j.	j.	PROPN
admet-1037	325	31	kihlberg	kihlberg	PROPN
admet-1037	325	32	.	.	PUNCT
admet-1037	326	1	impact	impact	NOUN
admet-1037	326	2	of	of	ADP
admet-1037	326	3	dynamically	dynamically	ADV
admet-1037	326	4	exposed	expose	VERB
admet-1037	326	5	polarity	polarity	NOUN
admet-1037	326	6	on	on	ADP
admet-1037	326	7	permeability	permeability	NOUN
admet-1037	326	8	and	and	CCONJ
admet-1037	326	9	solubility	solubility	NOUN
admet-1037	326	10	of	of	ADP
admet-1037	326	11	chameleonic	chameleonic	ADJ
admet-1037	326	12	drugs	drug	NOUN
admet-1037	326	13	beyond	beyond	ADP
admet-1037	326	14	the	the	DET
admet-1037	326	15	rule	rule	NOUN
admet-1037	326	16	of	of	ADP
admet-1037	326	17	5	5	NUM
admet-1037	326	18	.	.	PUNCT
admet-1037	326	19	journal	journal	PROPN
admet-1037	326	20	of	of	ADP
admet-1037	326	21	medicinal	medicinal	ADJ
admet-1037	326	22	chemistry	chemistry	NOUN
admet-1037	326	23	61	61	NUM
admet-1037	326	24	(	(	PUNCT
admet-1037	326	25	2018	2018	NUM
admet-1037	326	26	)	)	PUNCT
admet-1037	326	27	4189–4202	4189–4202	NUM
admet-1037	326	28	.	.	PUNCT
admet-1037	327	1	https://doi.org/10.1021/acs.jmedchem.8b00347	https://doi.org/10.1021/acs.jmedchem.8b00347	ADJ
admet-1037	327	2	.	.	PUNCT
admet-1037	328	1	[	[	X
admet-1037	328	2	28	28	NUM
admet-1037	328	3	]	]	X
admet-1037	328	4	g.	g.	PROPN
admet-1037	328	5	caron	caron	PROPN
admet-1037	328	6	,	,	PUNCT
admet-1037	328	7	j.	j.	PROPN
admet-1037	328	8	kihlberg	kihlberg	PROPN
admet-1037	328	9	,	,	PUNCT
admet-1037	328	10	g.	g.	PROPN
admet-1037	328	11	ermondi	ermondi	PROPN
admet-1037	328	12	.	.	PUNCT
admet-1037	329	1	intramolecular	intramolecular	ADJ
admet-1037	329	2	hydrogen	hydrogen	NOUN
admet-1037	329	3	bonding	bonding	NOUN
admet-1037	329	4	:	:	PUNCT
admet-1037	329	5	an	an	DET
admet-1037	329	6	opportunity	opportunity	NOUN
admet-1037	329	7	for	for	ADP
admet-1037	329	8	improved	improved	ADJ
admet-1037	329	9	design	design	NOUN
admet-1037	329	10	in	in	ADP
admet-1037	329	11	medicinal	medicinal	ADJ
admet-1037	329	12	chemistry	chemistry	NOUN
admet-1037	329	13	.	.	PUNCT
admet-1037	330	1	medicinal	medicinal	ADJ
admet-1037	330	2	research	research	NOUN
admet-1037	330	3	reviews	review	NOUN
admet-1037	330	4	39	39	NUM
admet-1037	330	5	(	(	PUNCT
admet-1037	330	6	2019	2019	NUM
admet-1037	330	7	)	)	PUNCT
admet-1037	330	8	1707–1729	1707–1729	NUM
admet-1037	330	9	.	.	PUNCT
admet-1037	331	1	https://doi.org/10.1002/med.21562	https://doi.org/10.1002/med.21562	INTJ
admet-1037	331	2	.	.	PUNCT
admet-1037	332	1	[	[	X
admet-1037	332	2	29	29	NUM
admet-1037	332	3	]	]	PUNCT
admet-1037	332	4	p.	p.	PROPN
admet-1037	332	5	matsson	matsson	PROPN
admet-1037	332	6	,	,	PUNCT
admet-1037	332	7	j.	j.	PROPN
admet-1037	332	8	kihlberg	kihlberg	PROPN
admet-1037	332	9	.	.	PUNCT
admet-1037	333	1	how	how	SCONJ
admet-1037	333	2	big	big	ADJ
admet-1037	333	3	is	be	AUX
admet-1037	333	4	too	too	ADV
admet-1037	333	5	big	big	ADJ
admet-1037	333	6	for	for	ADP
admet-1037	333	7	cell	cell	NOUN
admet-1037	333	8	permeability	permeability	NOUN
admet-1037	333	9	?	?	PUNCT
admet-1037	334	1	journal	journal	NOUN
admet-1037	334	2	of	of	ADP
admet-1037	334	3	medicinal	medicinal	ADJ
admet-1037	334	4	chemistry	chemistry	NOUN
admet-1037	334	5	60	60	NUM
admet-1037	334	6	(	(	PUNCT
admet-1037	334	7	2017	2017	NUM
admet-1037	334	8	)	)	PUNCT
admet-1037	334	9	1662–1664	1662–1664	NUM
admet-1037	334	10	.	.	PUNCT
admet-1037	335	1	https://doi.org/10.1021/acs.jmedchem.7b00237	https://doi.org/10.1021/acs.jmedchem.7b00237	X
admet-1037	335	2	.	.	PUNCT
admet-1037	336	1	[	[	X
admet-1037	336	2	30	30	NUM
admet-1037	336	3	]	]	X
admet-1037	336	4	y.	y.	PROPN
admet-1037	336	5	atilaw	atilaw	PROPN
admet-1037	336	6	,	,	PUNCT
admet-1037	336	7	v.	v.	ADP
admet-1037	336	8	poongavanam	poongavanam	PROPN
admet-1037	336	9	,	,	PUNCT
admet-1037	336	10	c.	c.	PROPN
admet-1037	336	11	svensson	svensson	PROPN
admet-1037	336	12	nilsson	nilsson	PROPN
admet-1037	336	13	,	,	PUNCT
admet-1037	336	14	d.	d.	PROPN
admet-1037	336	15	nguyen	nguyen	PROPN
admet-1037	336	16	,	,	PUNCT
admet-1037	336	17	a.	a.	NOUN
admet-1037	336	18	giese	giese	PROPN
admet-1037	336	19	,	,	PUNCT
admet-1037	336	20	d.	d.	PROPN
admet-1037	336	21	meibom	meibom	PROPN
admet-1037	336	22	,	,	PUNCT
admet-1037	336	23	m.	m.	NOUN
admet-1037	336	24	erdelyi	erdelyi	NOUN
admet-1037	336	25	,	,	PUNCT
admet-1037	336	26	j.	j.	PROPN
admet-1037	336	27	kihlberg	kihlberg	PROPN
admet-1037	336	28	.	.	PUNCT
admet-1037	337	1	solution	solution	NOUN
admet-1037	337	2	conformations	conformation	NOUN
admet-1037	337	3	shed	shed	VERB
admet-1037	337	4	light	light	NOUN
admet-1037	337	5	on	on	ADP
admet-1037	337	6	protac	protac	ADJ
admet-1037	337	7	cell	cell	NOUN
admet-1037	337	8	permeability	permeability	NOUN
admet-1037	337	9	.	.	PUNCT
admet-1037	338	1	acs	acs	PROPN
admet-1037	338	2	medicinal	medicinal	ADJ
admet-1037	338	3	chemistry	chemistry	NOUN
admet-1037	338	4	letters	letter	NOUN
admet-1037	338	5	12	12	NUM
admet-1037	338	6	(	(	PUNCT
admet-1037	338	7	2021	2021	NUM
admet-1037	338	8	)	)	PUNCT
admet-1037	338	9	107–114	107–114	NUM
admet-1037	338	10	.	.	PUNCT
admet-1037	339	1	https://doi.org/10.1021/acsmedchemlett.0c00556	https://doi.org/10.1021/acsmedchemlett.0c00556	NOUN
admet-1037	339	2	.	.	PUNCT
admet-1037	340	1	[	[	X
admet-1037	340	2	31	31	NUM
admet-1037	340	3	]	]	X
admet-1037	340	4	d.e	d.e	PROPN
admet-1037	340	5	.	.	PROPN
admet-1037	340	6	scott	scott	PROPN
admet-1037	340	7	,	,	PUNCT
admet-1037	340	8	t.p.c	t.p.c	PROPN
admet-1037	340	9	.	.	PUNCT
admet-1037	340	10	rooney	rooney	PROPN
admet-1037	340	11	,	,	PUNCT
admet-1037	340	12	e.d	e.d	PROPN
admet-1037	340	13	.	.	PROPN
admet-1037	340	14	bayle	bayle	PROPN
admet-1037	340	15	,	,	PUNCT
admet-1037	340	16	t.	t.	PROPN
admet-1037	340	17	mirza	mirza	PROPN
admet-1037	340	18	,	,	PUNCT
admet-1037	340	19	h.m.g	h.m.g	PROPN
admet-1037	340	20	.	.	PUNCT
admet-1037	341	1	willems	willems	PROPN
admet-1037	341	2	,	,	PUNCT
admet-1037	341	3	j.h	j.h	PROPN
admet-1037	341	4	.	.	PROPN
admet-1037	341	5	clarke	clarke	PROPN
admet-1037	341	6	,	,	PUNCT
admet-1037	341	7	s.p	s.p	PROPN
admet-1037	341	8	.	.	PROPN
admet-1037	341	9	andrews	andrews	PROPN
admet-1037	341	10	,	,	PUNCT
admet-1037	341	11	j.	j.	PROPN
admet-1037	341	12	skidmore	skidmore	PROPN
admet-1037	341	13	.	.	PUNCT
admet-1037	342	1	systematic	systematic	ADJ
admet-1037	342	2	investigation	investigation	NOUN
admet-1037	342	3	of	of	ADP
admet-1037	342	4	the	the	DET
admet-1037	342	5	permeability	permeability	NOUN
admet-1037	342	6	of	of	ADP
admet-1037	342	7	androgen	androgen	NOUN
admet-1037	342	8	receptor	receptor	NOUN
admet-1037	342	9	protacs	protac	NOUN
admet-1037	342	10	.	.	PUNCT
admet-1037	343	1	acs	acs	PROPN
admet-1037	343	2	medicinal	medicinal	ADJ
admet-1037	343	3	chemistry	chemistry	NOUN
admet-1037	343	4	letters	letter	NOUN
admet-1037	343	5	11	11	NUM
admet-1037	343	6	(	(	PUNCT
admet-1037	343	7	2020	2020	NUM
admet-1037	343	8	)	)	PUNCT
admet-1037	343	9	1539–1547	1539–1547	NUM
admet-1037	343	10	.	.	PUNCT
admet-1037	344	1	https://doi.org/10.1021/acsmedchemlett.0c00194	https://doi.org/10.1021/acsmedchemlett.0c00194	PROPN
admet-1037	344	2	.	.	PUNCT
admet-1037	345	1	[	[	X
admet-1037	345	2	32	32	NUM
admet-1037	345	3	]	]	X
admet-1037	345	4	v.g	v.g	PROPN
admet-1037	345	5	.	.	PROPN
admet-1037	345	6	klein	klein	PROPN
admet-1037	345	7	,	,	PUNCT
admet-1037	345	8	c.e	c.e	PROPN
admet-1037	345	9	.	.	PROPN
admet-1037	345	10	townsend	townsend	PROPN
admet-1037	345	11	,	,	PUNCT
admet-1037	345	12	a.	a.	PROPN
admet-1037	345	13	testa	testa	PROPN
admet-1037	345	14	,	,	PUNCT
admet-1037	345	15	m.	m.	NOUN
admet-1037	345	16	zengerle	zengerle	PROPN
admet-1037	345	17	,	,	PUNCT
admet-1037	345	18	c.	c.	PROPN
admet-1037	345	19	maniaci	maniaci	PROPN
admet-1037	345	20	,	,	PUNCT
admet-1037	345	21	s.j	s.j	PROPN
admet-1037	345	22	.	.	PROPN
admet-1037	345	23	hughes	hughes	PROPN
admet-1037	345	24	,	,	PUNCT
admet-1037	345	25	k.h	k.h	PROPN
admet-1037	345	26	.	.	PROPN
admet-1037	345	27	chan	chan	PROPN
admet-1037	345	28	,	,	PUNCT
admet-1037	345	29	a.	a.	PROPN
admet-1037	345	30	ciulli	ciulli	PROPN
admet-1037	345	31	,	,	PUNCT
admet-1037	345	32	r.s	r.s	PROPN
admet-1037	345	33	.	.	PROPN
admet-1037	345	34	lokey	lokey	PROPN
admet-1037	345	35	.	.	PUNCT
admet-1037	346	1	understanding	understanding	NOUN
admet-1037	346	2	and	and	CCONJ
admet-1037	346	3	improving	improve	VERB
admet-1037	346	4	the	the	DET
admet-1037	346	5	membrane	membrane	NOUN
admet-1037	346	6	permeability	permeability	NOUN
admet-1037	346	7	of	of	ADP
admet-1037	346	8	vh032	vh032	NOUN
admet-1037	346	9	-	-	PUNCT
admet-1037	346	10	based	base	VERB
admet-1037	346	11	protacs	protac	NOUN
admet-1037	346	12	.	.	PUNCT
admet-1037	347	1	acs	acs	PROPN
admet-1037	347	2	medicinal	medicinal	ADJ
admet-1037	347	3	chemistry	chemistry	NOUN
admet-1037	347	4	letters	letter	NOUN
admet-1037	347	5	11	11	NUM
admet-1037	347	6	(	(	PUNCT
admet-1037	347	7	2020	2020	NUM
admet-1037	347	8	)	)	PUNCT
admet-1037	347	9	1732–1738	1732–1738	NOUN
admet-1037	347	10	.	.	PUNCT
admet-1037	348	1	https://doi.org/10.1021/acsmedchemlett.0c00265	https://doi.org/10.1021/acsmedchemlett.0c00265	NOUN
admet-1037	348	2	.	.	PUNCT
admet-1037	349	1	©	©	NOUN
admet-1037	349	2	2021	2021	NUM
admet-1037	349	3	by	by	ADP
admet-1037	349	4	the	the	DET
admet-1037	349	5	authors	author	NOUN
admet-1037	349	6	;	;	PUNCT
admet-1037	349	7	licensee	licensee	PROPN
admet-1037	349	8	iapc	iapc	PROPN
admet-1037	349	9	,	,	PUNCT
admet-1037	349	10	zagreb	zagreb	PROPN
admet-1037	349	11	,	,	PUNCT
admet-1037	349	12	croatia	croatia	PROPN
admet-1037	349	13	.	.	PUNCT
admet-1037	350	1	this	this	DET
admet-1037	350	2	article	article	NOUN
admet-1037	350	3	is	be	AUX
admet-1037	350	4	an	an	DET
admet-1037	350	5	open	open	ADJ
admet-1037	350	6	-	-	PUNCT
admet-1037	350	7	access	access	NOUN
admet-1037	350	8	article	article	NOUN
admet-1037	350	9	distributed	distribute	VERB
admet-1037	350	10	under	under	ADP
admet-1037	350	11	the	the	DET
admet-1037	350	12	terms	term	NOUN
admet-1037	350	13	and	and	CCONJ
admet-1037	350	14	conditions	condition	NOUN
admet-1037	350	15	of	of	ADP
admet-1037	350	16	the	the	DET
admet-1037	350	17	creative	creative	ADJ
admet-1037	350	18	commons	common	NOUN
admet-1037	350	19	attribution	attribution	NOUN
admet-1037	350	20	license	license	NOUN
admet-1037	350	21	(	(	PUNCT
admet-1037	350	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-1037	350	23	)	)	PUNCT
admet-1037	350	24	https://doi.org/10.1021/ci025515j	https://doi.org/10.1021/ci025515j	PROPN
admet-1037	350	25	https://doi.org/10.1016/j.ejmech.2021.113247	https://doi.org/10.1016/j.ejmech.2021.113247	ADJ
admet-1037	350	26	https://doi.org/10.1016/j.ejmech.2021.113247	https://doi.org/10.1016/j.ejmech.2021.113247	ADJ
admet-1037	350	27	https://doi.org/10.2174/156802606775193310	https://doi.org/10.2174/156802606775193310	NOUN
admet-1037	350	28	https://doi.org/10.1021/acsomega.8b01379	https://doi.org/10.1021/acsomega.8b01379	PROPN
admet-1037	350	29	https://doi.org/10.1016/j.drudis.2020.06.015	https://doi.org/10.1016/j.drudis.2020.06.015	PROPN
admet-1037	350	30	https://doi.org/10.1016/j.drudis.2020.06.015	https://doi.org/10.1016/j.drudis.2020.06.015	PROPN
admet-1037	350	31	https://doi.org/10.1016/j.drudis.2016.02.005	https://doi.org/10.1016/j.drudis.2016.02.005	VERB
admet-1037	350	32	https://doi.org/10.1021/acs.jmedchem.8b00347	https://doi.org/10.1021/acs.jmedchem.8b00347	ADJ
admet-1037	351	1	https://doi.org/10.1021/acs.jmedchem.7b00237	https://doi.org/10.1021/acs.jmedchem.7b00237	PROPN
admet-1037	351	2	https://doi.org/10.1021/acsmedchemlett.0c00556	https://doi.org/10.1021/acsmedchemlett.0c00556	X
admet-1037	351	3	https://doi.org/10.1021/acsmedchemlett.0c00194	https://doi.org/10.1021/acsmedchemlett.0c00194	PROPN
admet-1037	351	4	https://doi.org/10.1021/acsmedchemlett.0c00265	https://doi.org/10.1021/acsmedchemlett.0c00265	NOUN
admet-1037	351	5	https://doi.org/10.1021/acsmedchemlett.0c00265	https://doi.org/10.1021/acsmedchemlett.0c00265	NOUN
admet-1037	351	6	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN