id	sid	tid	token	lemma	pos
admet-1209	1	1	new	new	ADJ
admet-1209	1	2	therapeutic	therapeutic	ADJ
admet-1209	1	3	modalities	modality	NOUN
admet-1209	1	4	in	in	ADP
admet-1209	1	5	drug	drug	NOUN
admet-1209	1	6	discovery	discovery	NOUN
admet-1209	1	7	and	and	CCONJ
admet-1209	1	8	development	development	NOUN
admet-1209	1	9	:	:	PUNCT
admet-1209	1	10	insights	insight	NOUN
admet-1209	1	11	&	&	CCONJ
admet-1209	1	12	opportunities	opportunity	NOUN
admet-1209	1	13	doi	doi	PROPN
admet-1209	1	14	:	:	PUNCT
admet-1209	1	15	http://doi.org/10.5599/admet.1209	http://doi.org/10.5599/admet.1209	PROPN
admet-1209	1	16	227	227	NUM
admet-1209	1	17	admet	admet	PROPN
admet-1209	1	18	&	&	CCONJ
admet-1209	1	19	dmpk	dmpk	PROPN
admet-1209	1	20	9(4	9(4	PROPN
admet-1209	1	21	)	)	PUNCT
admet-1209	1	22	(	(	PUNCT
admet-1209	1	23	2021	2021	NUM
admet-1209	1	24	)	)	PUNCT
admet-1209	1	25	227	227	NUM
admet-1209	1	26	-	-	SYM
admet-1209	1	27	230	230	NUM
admet-1209	1	28	;	;	PUNCT
admet-1209	1	29	doi	doi	NOUN
admet-1209	1	30	:	:	PUNCT
admet-1209	1	31	http://dx.doi.org/10.5599/admet.1209	http://dx.doi.org/10.5599/admet.1209	VERB
admet-1209	1	32	open	open	ADJ
admet-1209	1	33	access	access	NOUN
admet-1209	1	34	:	:	PUNCT
admet-1209	1	35	issn	issn	PROPN
admet-1209	1	36	:	:	PUNCT
admet-1209	1	37	1848	1848	NUM
admet-1209	1	38	-	-	SYM
admet-1209	1	39	7718	7718	NUM
admet-1209	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1209	1	41	editorial	editorial	NOUN
admet-1209	1	42	new	new	ADJ
admet-1209	1	43	therapeutic	therapeutic	ADJ
admet-1209	1	44	modalities	modality	NOUN
admet-1209	1	45	in	in	ADP
admet-1209	1	46	drug	drug	NOUN
admet-1209	1	47	discovery	discovery	NOUN
admet-1209	1	48	and	and	CCONJ
admet-1209	1	49	development	development	NOUN
admet-1209	1	50	:	:	PUNCT
admet-1209	1	51	insights	insight	NOUN
admet-1209	1	52	&	&	CCONJ
admet-1209	1	53	opportunities	opportunity	NOUN
admet-1209	1	54	manfred	manfre	VERB
admet-1209	1	55	kansy1	kansy1	PROPN
admet-1209	1	56	and	and	CCONJ
admet-1209	1	57	giulia	giulia	PROPN
admet-1209	1	58	caron2	caron2	NOUN
admet-1209	1	59	1	1	NUM
admet-1209	1	60	independent	independent	ADJ
admet-1209	1	61	consultant	consultant	NOUN
admet-1209	1	62	,	,	PUNCT
admet-1209	1	63	79111	79111	NUM
admet-1209	1	64	,	,	PUNCT
admet-1209	1	65	freiburg	freiburg	PROPN
admet-1209	2	1	i	i	PROPN
admet-1209	2	2	m	m	VERB
admet-1209	2	3	breisgau	breisgau	NOUN
admet-1209	2	4	,	,	PUNCT
admet-1209	2	5	germany	germany	PROPN
admet-1209	2	6	(	(	PUNCT
admet-1209	2	7	manfred.kansy1@gmail.com	manfred.kansy1@gmail.com	NOUN
admet-1209	2	8	)	)	PUNCT
admet-1209	2	9	2	2	NUM
admet-1209	2	10	department	department	NOUN
admet-1209	2	11	of	of	ADP
admet-1209	2	12	molecular	molecular	ADJ
admet-1209	2	13	biotechnology	biotechnology	NOUN
admet-1209	2	14	and	and	CCONJ
admet-1209	2	15	health	health	NOUN
admet-1209	2	16	sciences	science	NOUN
admet-1209	2	17	,	,	PUNCT
admet-1209	2	18	university	university	NOUN
admet-1209	2	19	of	of	ADP
admet-1209	2	20	torino	torino	NOUN
admet-1209	2	21	,	,	PUNCT
admet-1209	2	22	quarello	quarello	ADV
admet-1209	2	23	15	15	NUM
admet-1209	2	24	,	,	PUNCT
admet-1209	2	25	10135	10135	NUM
admet-1209	2	26	torino	torino	NOUN
admet-1209	2	27	,	,	PUNCT
admet-1209	2	28	italy	italy	PROPN
admet-1209	2	29	(	(	PUNCT
admet-1209	2	30	giulia.caron@unito.it	giulia.caron@unito.it	PROPN
admet-1209	2	31	)	)	PUNCT
admet-1209	2	32	received	receive	VERB
admet-1209	2	33	:	:	PUNCT
admet-1209	2	34	december	december	PROPN
admet-1209	2	35	11	11	NUM
admet-1209	2	36	,	,	PUNCT
admet-1209	2	37	2021	2021	NUM
admet-1209	2	38	;	;	PUNCT
admet-1209	2	39	revised	revise	VERB
admet-1209	2	40	:	:	PUNCT
admet-1209	2	41	december	december	PROPN
admet-1209	2	42	13	13	NUM
admet-1209	2	43	,	,	PUNCT
admet-1209	2	44	2021	2021	NUM
admet-1209	2	45	;	;	PUNCT
admet-1209	2	46	published	publish	VERB
admet-1209	2	47	:	:	PUNCT
admet-1209	2	48	december	december	PROPN
admet-1209	2	49	15	15	NUM
admet-1209	2	50	,	,	PUNCT
admet-1209	2	51	2021	2021	NUM
admet-1209	2	52	the	the	DET
admet-1209	2	53	study	study	NOUN
admet-1209	2	54	of	of	ADP
admet-1209	2	55	the	the	DET
admet-1209	2	56	statistics	statistic	NOUN
admet-1209	2	57	of	of	ADP
admet-1209	2	58	new	new	ADJ
admet-1209	2	59	drug	drug	NOUN
admet-1209	2	60	registrations	registration	NOUN
admet-1209	2	61	over	over	ADP
admet-1209	2	62	time	time	NOUN
admet-1209	2	63	shows	show	VERB
admet-1209	2	64	an	an	DET
admet-1209	2	65	interesting	interesting	ADJ
admet-1209	2	66	pattern	pattern	NOUN
admet-1209	2	67	.	.	PUNCT
admet-1209	3	1	at	at	ADP
admet-1209	3	2	the	the	DET
admet-1209	3	3	end	end	NOUN
admet-1209	3	4	of	of	ADP
admet-1209	3	5	the	the	DET
admet-1209	3	6	last	last	ADJ
admet-1209	3	7	century	century	NOUN
admet-1209	3	8	,	,	PUNCT
admet-1209	3	9	productivity	productivity	NOUN
admet-1209	3	10	,	,	PUNCT
admet-1209	3	11	measured	measure	VERB
admet-1209	3	12	in	in	ADP
admet-1209	3	13	terms	term	NOUN
admet-1209	3	14	of	of	ADP
admet-1209	3	15	market	market	NOUN
admet-1209	3	16	launches	launch	NOUN
admet-1209	3	17	,	,	PUNCT
admet-1209	3	18	was	be	AUX
admet-1209	3	19	declining	decline	VERB
admet-1209	3	20	and	and	CCONJ
admet-1209	3	21	charts	chart	NOUN
admet-1209	3	22	as	as	SCONJ
admet-1209	3	23	the	the	DET
admet-1209	3	24	one	one	NOUN
admet-1209	3	25	shown	show	VERB
admet-1209	3	26	in	in	ADP
admet-1209	3	27	figure	figure	NOUN
admet-1209	3	28	1	1	NUM
admet-1209	3	29	have	have	AUX
admet-1209	3	30	often	often	ADV
admet-1209	3	31	been	be	AUX
admet-1209	3	32	used	use	VERB
admet-1209	3	33	to	to	PART
admet-1209	3	34	highlight	highlight	VERB
admet-1209	3	35	potential	potential	ADJ
admet-1209	3	36	productivity	productivity	NOUN
admet-1209	3	37	losses	loss	NOUN
admet-1209	3	38	in	in	ADP
admet-1209	3	39	pharmaceutical	pharmaceutical	ADJ
admet-1209	3	40	r&d	r&d	NOUN
admet-1209	4	1	[	[	X
admet-1209	4	2	1,2	1,2	NUM
admet-1209	4	3	]	]	PUNCT
admet-1209	4	4	.	.	PUNCT
admet-1209	5	1	this	this	DET
admet-1209	5	2	trend	trend	NOUN
admet-1209	5	3	seems	seem	VERB
admet-1209	5	4	to	to	PART
admet-1209	5	5	have	have	AUX
admet-1209	5	6	reversed	reverse	VERB
admet-1209	5	7	in	in	ADP
admet-1209	5	8	the	the	DET
admet-1209	5	9	last	last	ADJ
admet-1209	5	10	decade	decade	NOUN
admet-1209	5	11	.	.	PUNCT
admet-1209	6	1	certainly	certainly	ADV
admet-1209	6	2	,	,	PUNCT
admet-1209	6	3	the	the	DET
admet-1209	6	4	number	number	NOUN
admet-1209	6	5	of	of	ADP
admet-1209	6	6	launches	launch	NOUN
admet-1209	6	7	alone	alone	ADV
admet-1209	6	8	is	be	AUX
admet-1209	6	9	not	not	PART
admet-1209	6	10	a	a	DET
admet-1209	6	11	good	good	ADJ
admet-1209	6	12	measure	measure	NOUN
admet-1209	6	13	of	of	ADP
admet-1209	6	14	productivity	productivity	NOUN
admet-1209	6	15	and	and	CCONJ
admet-1209	6	16	other	other	ADJ
admet-1209	6	17	,	,	PUNCT
admet-1209	6	18	partly	partly	ADV
admet-1209	6	19	controversially	controversially	ADV
admet-1209	6	20	discussed	discuss	VERB
admet-1209	6	21	measures	measure	NOUN
admet-1209	6	22	have	have	AUX
admet-1209	6	23	been	be	AUX
admet-1209	6	24	applied	apply	VERB
admet-1209	6	25	[	[	PUNCT
admet-1209	6	26	3	3	NUM
admet-1209	6	27	-	-	SYM
admet-1209	6	28	5	5	NUM
admet-1209	6	29	]	]	PUNCT
admet-1209	6	30	.	.	PUNCT
admet-1209	7	1	figure	figure	NOUN
admet-1209	7	2	1	1	NUM
admet-1209	7	3	.	.	PUNCT
admet-1209	8	1	visualization	visualization	NOUN
admet-1209	8	2	of	of	ADP
admet-1209	8	3	cder	cder	NOUN
admet-1209	8	4	new	new	ADJ
admet-1209	8	5	molecular	molecular	ADJ
admet-1209	8	6	entity	entity	NOUN
admet-1209	8	7	(	(	PUNCT
admet-1209	8	8	nme	nme	PROPN
admet-1209	8	9	)	)	PUNCT
admet-1209	8	10	drug	drug	NOUN
admet-1209	8	11	and	and	CCONJ
admet-1209	8	12	new	new	ADJ
admet-1209	8	13	biologic	biologic	NOUN
admet-1209	8	14	approvals	approval	NOUN
admet-1209	8	15	1985	1985	NUM
admet-1209	8	16	-	-	SYM
admet-1209	8	17	2021	2021	NUM
admet-1209	8	18	[	[	X
admet-1209	8	19	6	6	NUM
admet-1209	8	20	]	]	PUNCT
admet-1209	8	21	.	.	PUNCT
admet-1209	9	1	what	what	PRON
admet-1209	9	2	might	might	AUX
admet-1209	9	3	be	be	AUX
admet-1209	9	4	the	the	DET
admet-1209	9	5	reason	reason	NOUN
admet-1209	9	6	for	for	ADP
admet-1209	9	7	this	this	DET
admet-1209	9	8	potentially	potentially	ADV
admet-1209	9	9	positive	positive	ADJ
admet-1209	9	10	trend	trend	NOUN
admet-1209	9	11	of	of	ADP
admet-1209	9	12	increasing	increase	VERB
admet-1209	9	13	numbers	number	NOUN
admet-1209	9	14	of	of	ADP
admet-1209	9	15	nmes	nme	NOUN
admet-1209	9	16	and	and	CCONJ
admet-1209	9	17	biologics	biologic	NOUN
admet-1209	9	18	approvals	approval	NOUN
admet-1209	9	19	over	over	ADP
admet-1209	9	20	the	the	DET
admet-1209	9	21	last	last	ADJ
admet-1209	9	22	ten	ten	NUM
admet-1209	9	23	years	year	NOUN
admet-1209	9	24	?	?	PUNCT
admet-1209	10	1	it	it	PRON
admet-1209	10	2	is	be	AUX
admet-1209	10	3	obvious	obvious	ADJ
admet-1209	10	4	that	that	SCONJ
admet-1209	10	5	massive	massive	ADJ
admet-1209	10	6	efforts	effort	NOUN
admet-1209	10	7	in	in	ADP
admet-1209	10	8	strategy	strategy	NOUN
admet-1209	10	9	adjustments	adjustment	NOUN
admet-1209	10	10	,	,	PUNCT
admet-1209	10	11	early	early	ADJ
admet-1209	10	12	admet	admet	X
admet-1209	10	13	optimization	optimization	NOUN
admet-1209	10	14	and	and	CCONJ
admet-1209	10	15	the	the	DET
admet-1209	10	16	introduction	introduction	NOUN
admet-1209	10	17	of	of	ADP
admet-1209	10	18	new	new	ADJ
admet-1209	10	19	assays	assay	NOUN
admet-1209	10	20	,	,	PUNCT
admet-1209	10	21	methods	method	NOUN
admet-1209	10	22	and	and	CCONJ
admet-1209	10	23	computational	computational	ADJ
admet-1209	10	24	techniques	technique	NOUN
admet-1209	10	25	by	by	ADP
admet-1209	10	26	pharmaceutical	pharmaceutical	ADJ
admet-1209	10	27	r	r	NOUN
admet-1209	10	28	&	&	CCONJ
admet-1209	10	29	d	d	PROPN
admet-1209	10	30	and	and	CCONJ
admet-1209	10	31	academia	academia	NOUN
admet-1209	10	32	have	have	AUX
admet-1209	10	33	had	have	VERB
admet-1209	10	34	an	an	DET
admet-1209	10	35	effect	effect	NOUN
admet-1209	10	36	.	.	PUNCT
admet-1209	11	1	new	new	ADJ
admet-1209	11	2	disease	disease	NOUN
admet-1209	11	3	-	-	PUNCT
admet-1209	11	4	relevant	relevant	ADJ
admet-1209	11	5	targets	target	NOUN
admet-1209	11	6	have	have	AUX
admet-1209	11	7	been	be	AUX
admet-1209	11	8	identified	identify	VERB
admet-1209	11	9	and	and	CCONJ
admet-1209	11	10	potential	potential	ADJ
admet-1209	11	11	improvements	improvement	NOUN
admet-1209	11	12	in	in	ADP
admet-1209	11	13	regulatory	regulatory	ADJ
admet-1209	11	14	processes	process	NOUN
admet-1209	11	15	could	could	AUX
admet-1209	11	16	have	have	AUX
admet-1209	11	17	been	be	AUX
admet-1209	11	18	beneficial	beneficial	ADJ
admet-1209	11	19	.	.	PUNCT
admet-1209	12	1	moreover	moreover	ADV
admet-1209	12	2	,	,	PUNCT
admet-1209	12	3	the	the	DET
admet-1209	12	4	introduction	introduction	NOUN
admet-1209	12	5	of	of	ADP
admet-1209	12	6	new	new	ADJ
admet-1209	12	7	therapeutic	therapeutic	ADJ
admet-1209	12	8	http://dx.doi.org/10.5599/admet.1209	http://dx.doi.org/10.5599/admet.1209	NOUN
admet-1209	12	9	http://dx.doi.org/10.5599/admet.1209	http://dx.doi.org/10.5599/admet.1209	NOUN
admet-1209	12	10	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1209	12	11	mailto:manfred.kansy1@gmail.com	mailto:manfred.kansy1@gmail.com	PROPN
admet-1209	12	12	mailto:giulia.caron@unito.it	mailto:giulia.caron@unito.it	PROPN
admet-1209	12	13	m.	m.	PROPN
admet-1209	12	14	kansy	kansy	PROPN
admet-1209	12	15	,	,	PUNCT
admet-1209	12	16	g.	g.	PROPN
admet-1209	12	17	caron	caron	PROPN
admet-1209	12	18	admet	admet	PROPN
admet-1209	12	19	&	&	CCONJ
admet-1209	12	20	dmpk	dmpk	PROPN
admet-1209	12	21	9(4	9(4	PROPN
admet-1209	12	22	)	)	PUNCT
admet-1209	12	23	(	(	PUNCT
admet-1209	12	24	2021	2021	NUM
admet-1209	12	25	)	)	PUNCT
admet-1209	12	26	227	227	NUM
admet-1209	12	27	-	-	SYM
admet-1209	12	28	230	230	NUM
admet-1209	12	29	228	228	NUM
admet-1209	12	30	modalities	modality	NOUN
admet-1209	12	31	,	,	PUNCT
admet-1209	12	32	besides	besides	SCONJ
admet-1209	12	33	the	the	DET
admet-1209	12	34	so	so	ADV
admet-1209	12	35	-	-	PUNCT
admet-1209	12	36	called	call	VERB
admet-1209	12	37	classical	classical	ADJ
admet-1209	12	38	rule	rule	NOUN
admet-1209	12	39	of	of	ADP
admet-1209	12	40	5	5	NUM
admet-1209	12	41	(	(	PUNCT
admet-1209	12	42	ro5	ro5	NOUN
admet-1209	12	43	)	)	PUNCT
admet-1209	13	1	[	[	X
admet-1209	13	2	7	7	NUM
admet-1209	13	3	]	]	SYM
admet-1209	13	4	compliant	compliant	ADJ
admet-1209	13	5	molecules	molecule	NOUN
admet-1209	13	6	,	,	PUNCT
admet-1209	13	7	has	have	AUX
admet-1209	13	8	had	have	VERB
admet-1209	13	9	some	some	DET
admet-1209	13	10	impact	impact	NOUN
admet-1209	13	11	.	.	PUNCT
admet-1209	14	1	antibodies	antibodie	VERB
admet-1209	14	2	,	,	PUNCT
admet-1209	14	3	antibody	antibody	NOUN
admet-1209	14	4	-	-	PUNCT
admet-1209	14	5	drug	drug	NOUN
admet-1209	14	6	conjugates	conjugate	NOUN
admet-1209	14	7	,	,	PUNCT
admet-1209	14	8	fusion	fusion	NOUN
admet-1209	14	9	proteins	protein	NOUN
admet-1209	14	10	,	,	PUNCT
admet-1209	14	11	neurotoxins	neurotoxin	NOUN
admet-1209	14	12	,	,	PUNCT
admet-1209	14	13	peptides	peptide	NOUN
admet-1209	14	14	,	,	PUNCT
admet-1209	14	15	polymers	polymer	NOUN
admet-1209	14	16	,	,	PUNCT
admet-1209	14	17	small	small	ADJ
admet-1209	14	18	interfering	interfere	VERB
admet-1209	14	19	rna	rna	NOUN
admet-1209	14	20	,	,	PUNCT
admet-1209	14	21	vaccines	vaccine	NOUN
admet-1209	14	22	,	,	PUNCT
admet-1209	14	23	etc	etc	X
admet-1209	14	24	.	.	X
admet-1209	14	25	,	,	PUNCT
admet-1209	14	26	are	be	AUX
admet-1209	14	27	reaching	reach	VERB
admet-1209	14	28	the	the	DET
admet-1209	14	29	market	market	NOUN
admet-1209	14	30	.	.	PUNCT
admet-1209	15	1	furthermore	furthermore	ADV
admet-1209	15	2	,	,	PUNCT
admet-1209	15	3	the	the	DET
admet-1209	15	4	introduction	introduction	NOUN
admet-1209	15	5	of	of	ADP
admet-1209	15	6	the	the	PRON
admet-1209	15	7	so	so	ADV
admet-1209	15	8	-	-	PUNCT
admet-1209	15	9	called	call	VERB
admet-1209	15	10	"	"	PUNCT
admet-1209	15	11	beyond	beyond	ADP
admet-1209	15	12	rule	rule	NOUN
admet-1209	15	13	of	of	ADP
admet-1209	15	14	five	five	NUM
admet-1209	15	15	compounds	compound	NOUN
admet-1209	15	16	"	"	PUNCT
admet-1209	15	17	(	(	PUNCT
admet-1209	15	18	bro5	bro5	PROPN
admet-1209	15	19	)	)	PUNCT
admet-1209	15	20	indicates	indicate	VERB
admet-1209	15	21	that	that	SCONJ
admet-1209	15	22	even	even	ADV
admet-1209	15	23	for	for	ADP
admet-1209	15	24	some	some	DET
admet-1209	15	25	demanding	demand	VERB
admet-1209	15	26	targets	target	NOUN
admet-1209	15	27	larger	large	ADJ
admet-1209	15	28	compounds	compound	NOUN
admet-1209	15	29	(	(	PUNCT
admet-1209	15	30	mw	mw	X
admet-1209	15	31	>	>	X
admet-1209	15	32	>	>	X
admet-1209	15	33	500	500	NUM
admet-1209	15	34	)	)	PUNCT
admet-1209	15	35	can	can	AUX
admet-1209	15	36	be	be	AUX
admet-1209	15	37	designed	design	VERB
admet-1209	15	38	and	and	CCONJ
admet-1209	15	39	optimized	optimize	VERB
admet-1209	15	40	to	to	PART
admet-1209	15	41	have	have	VERB
admet-1209	15	42	adequate	adequate	ADJ
admet-1209	15	43	admet	admet	NOUN
admet-1209	15	44	profiles	profile	NOUN
admet-1209	15	45	and	and	CCONJ
admet-1209	15	46	resulting	result	VERB
admet-1209	15	47	bioavailability	bioavailability	NOUN
admet-1209	15	48	with	with	ADP
admet-1209	15	49	desired	desire	VERB
admet-1209	15	50	in	in	ADP
admet-1209	15	51	vivo	vivo	ADJ
admet-1209	15	52	effect	effect	NOUN
admet-1209	15	53	.	.	PUNCT
admet-1209	16	1	although	although	SCONJ
admet-1209	16	2	general	general	ADJ
admet-1209	16	3	strategies	strategy	NOUN
admet-1209	16	4	to	to	PART
admet-1209	16	5	design	design	VERB
admet-1209	16	6	oral	oral	ADJ
admet-1209	16	7	bioavailable	bioavailable	ADJ
admet-1209	16	8	bro5	bro5	NOUN
admet-1209	16	9	drug	drug	NOUN
admet-1209	16	10	candidates	candidate	NOUN
admet-1209	16	11	have	have	AUX
admet-1209	16	12	not	not	PART
admet-1209	16	13	yet	yet	ADV
admet-1209	16	14	been	be	AUX
admet-1209	16	15	reported	report	VERB
admet-1209	16	16	,	,	PUNCT
admet-1209	16	17	conformational	conformational	ADJ
admet-1209	16	18	flexibility	flexibility	NOUN
admet-1209	16	19	has	have	AUX
admet-1209	16	20	been	be	AUX
admet-1209	16	21	identified	identify	VERB
admet-1209	16	22	as	as	ADP
admet-1209	16	23	an	an	DET
admet-1209	16	24	important	important	ADJ
admet-1209	16	25	parameter	parameter	NOUN
admet-1209	16	26	to	to	PART
admet-1209	16	27	describe	describe	VERB
admet-1209	16	28	the	the	DET
admet-1209	16	29	adme	adme	NOUN
admet-1209	16	30	profile	profile	NOUN
admet-1209	16	31	of	of	ADP
admet-1209	16	32	large	large	ADJ
admet-1209	16	33	and	and	CCONJ
admet-1209	16	34	flexible	flexible	ADJ
admet-1209	16	35	derivatives	derivative	NOUN
admet-1209	16	36	.	.	PUNCT
admet-1209	17	1	for	for	ADP
admet-1209	17	2	example	example	NOUN
admet-1209	17	3	,	,	PUNCT
admet-1209	17	4	it	it	PRON
admet-1209	17	5	has	have	AUX
admet-1209	17	6	been	be	AUX
admet-1209	17	7	recently	recently	ADV
admet-1209	17	8	shown	show	VERB
admet-1209	17	9	that	that	SCONJ
admet-1209	17	10	flexibility	flexibility	NOUN
admet-1209	17	11	descriptors	descriptor	NOUN
admet-1209	17	12	helped	help	VERB
admet-1209	17	13	to	to	PART
admet-1209	17	14	improve	improve	VERB
admet-1209	17	15	computational	computational	ADJ
admet-1209	17	16	solubility	solubility	NOUN
admet-1209	17	17	prediction	prediction	NOUN
admet-1209	17	18	of	of	ADP
admet-1209	17	19	bro5	bro5	NOUN
admet-1209	17	20	compounds	compound	NOUN
admet-1209	18	1	[	[	X
admet-1209	18	2	8	8	NUM
admet-1209	18	3	]	]	PUNCT
admet-1209	18	4	.	.	PUNCT
admet-1209	19	1	moreover	moreover	ADV
admet-1209	19	2	,	,	PUNCT
admet-1209	19	3	many	many	ADJ
admet-1209	19	4	bro5	bro5	NOUN
admet-1209	19	5	compounds	compound	NOUN
admet-1209	19	6	seem	seem	VERB
admet-1209	19	7	to	to	PART
admet-1209	19	8	have	have	VERB
admet-1209	19	9	an	an	DET
admet-1209	19	10	inherent	inherent	ADJ
admet-1209	19	11	potential	potential	NOUN
admet-1209	19	12	to	to	PART
admet-1209	19	13	conformationally	conformationally	ADV
admet-1209	19	14	adjust	adjust	VERB
admet-1209	19	15	to	to	ADP
admet-1209	19	16	the	the	DET
admet-1209	19	17	surrounding	surround	VERB
admet-1209	19	18	media	medium	NOUN
admet-1209	19	19	and	and	CCONJ
admet-1209	19	20	behave	behave	VERB
admet-1209	19	21	like	like	ADP
admet-1209	19	22	molecular	molecular	ADJ
admet-1209	19	23	chameleons	chameleon	NOUN
admet-1209	19	24	.	.	PUNCT
admet-1209	20	1	for	for	ADP
admet-1209	20	2	instance	instance	NOUN
admet-1209	20	3	,	,	PUNCT
admet-1209	20	4	the	the	DET
admet-1209	20	5	formation	formation	NOUN
admet-1209	20	6	of	of	ADP
admet-1209	20	7	intramolecular	intramolecular	ADJ
admet-1209	20	8	hydrogen	hydrogen	NOUN
admet-1209	20	9	bonds	bond	NOUN
admet-1209	20	10	in	in	ADP
admet-1209	20	11	an	an	DET
admet-1209	20	12	environment	environment	NOUN
admet-1209	20	13	-	-	PUNCT
admet-1209	20	14	dependent	dependent	ADJ
admet-1209	20	15	way	way	NOUN
admet-1209	20	16	has	have	AUX
admet-1209	20	17	been	be	AUX
admet-1209	20	18	analyzed	analyze	VERB
admet-1209	20	19	to	to	PART
admet-1209	20	20	explain	explain	VERB
admet-1209	20	21	the	the	DET
admet-1209	20	22	passive	passive	ADJ
admet-1209	20	23	permeability	permeability	NOUN
admet-1209	20	24	skills	skill	NOUN
admet-1209	20	25	of	of	ADP
admet-1209	20	26	some	some	DET
admet-1209	20	27	new	new	ADJ
admet-1209	20	28	therapeutic	therapeutic	ADJ
admet-1209	20	29	modalities	modality	NOUN
admet-1209	20	30	[	[	X
admet-1209	20	31	9,10	9,10	NUM
admet-1209	20	32	]	]	X
admet-1209	20	33	.	.	PUNCT
admet-1209	21	1	certainly	certainly	ADV
admet-1209	21	2	,	,	PUNCT
admet-1209	21	3	small	small	ADJ
admet-1209	21	4	molecules	molecule	NOUN
admet-1209	21	5	still	still	ADV
admet-1209	21	6	make	make	VERB
admet-1209	21	7	up	up	ADP
admet-1209	21	8	the	the	DET
admet-1209	21	9	majority	majority	NOUN
admet-1209	21	10	of	of	ADP
admet-1209	21	11	new	new	ADJ
admet-1209	21	12	drug	drug	NOUN
admet-1209	21	13	market	market	NOUN
admet-1209	21	14	introductions	introduction	NOUN
admet-1209	21	15	,	,	PUNCT
admet-1209	21	16	and	and	CCONJ
admet-1209	21	17	their	their	PRON
admet-1209	21	18	urgent	urgent	ADJ
admet-1209	21	19	need	need	NOUN
admet-1209	21	20	in	in	ADP
admet-1209	21	21	the	the	DET
admet-1209	21	22	treatment	treatment	NOUN
admet-1209	21	23	of	of	ADP
admet-1209	21	24	newly	newly	ADV
admet-1209	21	25	discovered	discover	VERB
admet-1209	21	26	diseases	disease	NOUN
admet-1209	21	27	and	and	CCONJ
admet-1209	21	28	the	the	DET
admet-1209	21	29	improvement	improvement	NOUN
admet-1209	21	30	of	of	ADP
admet-1209	21	31	current	current	ADJ
admet-1209	21	32	therapies	therapy	NOUN
admet-1209	21	33	is	be	AUX
admet-1209	21	34	impressively	impressively	ADV
admet-1209	21	35	demonstrated	demonstrate	VERB
admet-1209	21	36	during	during	ADP
admet-1209	21	37	the	the	DET
admet-1209	21	38	severe	severe	ADJ
admet-1209	21	39	ongoing	ongoing	ADJ
admet-1209	21	40	covid	covid	PROPN
admet-1209	21	41	19	19	NUM
admet-1209	21	42	pandemic	pandemic	NOUN
admet-1209	21	43	.	.	PUNCT
admet-1209	22	1	this	this	DET
admet-1209	22	2	special	special	ADJ
admet-1209	22	3	issue	issue	NOUN
admet-1209	22	4	of	of	ADP
admet-1209	22	5	admet	admet	PROPN
admet-1209	22	6	and	and	CCONJ
admet-1209	22	7	dmpk	dmpk	NOUN
admet-1209	22	8	describes	describe	VERB
admet-1209	22	9	new	new	ADJ
admet-1209	22	10	therapeutic	therapeutic	ADJ
admet-1209	22	11	modalities	modality	NOUN
admet-1209	22	12	,	,	PUNCT
admet-1209	22	13	innovative	innovative	ADJ
admet-1209	22	14	compound	compound	NOUN
admet-1209	22	15	characterization	characterization	NOUN
admet-1209	22	16	tools	tool	NOUN
admet-1209	22	17	for	for	ADP
admet-1209	22	18	drug	drug	NOUN
admet-1209	22	19	safety	safety	NOUN
admet-1209	22	20	evaluation	evaluation	NOUN
admet-1209	22	21	/	/	SYM
admet-1209	22	22	optimization	optimization	NOUN
admet-1209	22	23	and	and	CCONJ
admet-1209	22	24	newly	newly	ADV
admet-1209	22	25	developed	develop	VERB
admet-1209	22	26	computational	computational	ADJ
admet-1209	22	27	prediction	prediction	NOUN
admet-1209	22	28	tools	tool	NOUN
admet-1209	22	29	for	for	ADP
admet-1209	22	30	estimating	estimate	VERB
admet-1209	22	31	drug	drug	NOUN
admet-1209	22	32	brain	brain	NOUN
admet-1209	22	33	uptake	uptake	ADJ
admet-1209	22	34	as	as	ADP
admet-1209	22	35	examples	example	NOUN
admet-1209	22	36	of	of	ADP
admet-1209	22	37	how	how	SCONJ
admet-1209	22	38	the	the	DET
admet-1209	22	39	drug	drug	NOUN
admet-1209	22	40	discovery	discovery	NOUN
admet-1209	22	41	and	and	CCONJ
admet-1209	22	42	research	research	NOUN
admet-1209	22	43	fields	field	NOUN
admet-1209	22	44	are	be	AUX
admet-1209	22	45	continuously	continuously	ADV
admet-1209	22	46	innovating	innovate	VERB
admet-1209	22	47	and	and	CCONJ
admet-1209	22	48	adapting	adapt	VERB
admet-1209	22	49	to	to	ADP
admet-1209	22	50	the	the	DET
admet-1209	22	51	changing	change	VERB
admet-1209	22	52	needs	need	NOUN
admet-1209	22	53	.	.	PUNCT
admet-1209	23	1	in	in	ADP
admet-1209	23	2	a	a	DET
admet-1209	23	3	first	first	ADJ
admet-1209	23	4	impressive	impressive	ADJ
admet-1209	23	5	work	work	NOUN
admet-1209	23	6	,	,	PUNCT
admet-1209	23	7	experts	expert	NOUN
admet-1209	23	8	in	in	ADP
admet-1209	23	9	the	the	DET
admet-1209	23	10	field	field	NOUN
admet-1209	23	11	of	of	ADP
admet-1209	23	12	degraders	degrader	NOUN
admet-1209	23	13	,	,	PUNCT
admet-1209	23	14	i.e.	i.e.	X
admet-1209	23	15	,	,	PUNCT
admet-1209	23	16	bifunctional	bifunctional	ADJ
admet-1209	23	17	compounds	compound	NOUN
admet-1209	23	18	that	that	PRON
admet-1209	23	19	promote	promote	VERB
admet-1209	23	20	degradation	degradation	NOUN
admet-1209	23	21	of	of	ADP
admet-1209	23	22	target	target	NOUN
admet-1209	23	23	molecules	molecule	NOUN
admet-1209	23	24	instead	instead	ADV
admet-1209	23	25	of	of	ADP
admet-1209	23	26	inhibiting	inhibit	VERB
admet-1209	23	27	them	they	PRON
admet-1209	23	28	,	,	PUNCT
admet-1209	23	29	also	also	ADV
admet-1209	23	30	called	call	VERB
admet-1209	23	31	protacs	protac	NOUN
admet-1209	23	32	(	(	PUNCT
admet-1209	23	33	proteolysis	proteolysis	NOUN
admet-1209	23	34	targeting	target	VERB
admet-1209	23	35	chimeras	chimera	NOUN
admet-1209	23	36	)	)	PUNCT
admet-1209	23	37	,	,	PUNCT
admet-1209	23	38	have	have	AUX
admet-1209	23	39	analyzed	analyze	VERB
admet-1209	23	40	degrader	degrad	ADJ
admet-1209	23	41	data	datum	NOUN
admet-1209	23	42	in	in	ADP
admet-1209	23	43	terms	term	NOUN
admet-1209	23	44	of	of	ADP
admet-1209	23	45	target	target	NOUN
admet-1209	23	46	distribution	distribution	NOUN
admet-1209	23	47	[	[	X
admet-1209	23	48	11	11	NUM
admet-1209	23	49	]	]	PUNCT
admet-1209	23	50	.	.	PUNCT
admet-1209	24	1	moreover	moreover	ADV
admet-1209	24	2	,	,	PUNCT
admet-1209	24	3	they	they	PRON
admet-1209	24	4	impressively	impressively	ADV
admet-1209	24	5	demonstrate	demonstrate	VERB
admet-1209	24	6	how	how	SCONJ
admet-1209	24	7	such	such	ADJ
admet-1209	24	8	large	large	ADJ
admet-1209	24	9	and	and	CCONJ
admet-1209	24	10	partially	partially	ADV
admet-1209	24	11	flexible	flexible	ADJ
admet-1209	24	12	bro5	bro5	NOUN
admet-1209	24	13	drug	drug	NOUN
admet-1209	24	14	molecules	molecule	NOUN
admet-1209	24	15	can	can	AUX
admet-1209	24	16	be	be	AUX
admet-1209	24	17	engineered	engineer	VERB
admet-1209	24	18	in	in	ADP
admet-1209	24	19	a	a	DET
admet-1209	24	20	more	more	ADV
admet-1209	24	21	rational	rational	ADJ
admet-1209	24	22	way	way	NOUN
admet-1209	24	23	to	to	PART
admet-1209	24	24	improve	improve	VERB
admet-1209	24	25	admet	admet	NOUN
admet-1209	24	26	properties	property	NOUN
admet-1209	24	27	.	.	PUNCT
admet-1209	25	1	this	this	DET
admet-1209	25	2	excellent	excellent	ADJ
admet-1209	25	3	work	work	NOUN
admet-1209	25	4	by	by	ADP
admet-1209	25	5	giuseppe	giuseppe	PROPN
admet-1209	25	6	ermondi	ermondi	PROPN
admet-1209	25	7	and	and	CCONJ
admet-1209	25	8	his	his	PRON
admet-1209	25	9	colleagues	colleague	NOUN
admet-1209	25	10	at	at	ADP
admet-1209	25	11	the	the	DET
admet-1209	25	12	university	university	PROPN
admet-1209	25	13	of	of	ADP
admet-1209	25	14	turin	turin	PROPN
admet-1209	25	15	may	may	AUX
admet-1209	25	16	be	be	AUX
admet-1209	25	17	of	of	ADP
admet-1209	25	18	even	even	ADV
admet-1209	25	19	greater	great	ADJ
admet-1209	25	20	interest	interest	NOUN
admet-1209	25	21	,	,	PUNCT
admet-1209	25	22	as	as	SCONJ
admet-1209	25	23	preliminary	preliminary	ADJ
admet-1209	25	24	results	result	NOUN
admet-1209	25	25	from	from	ADP
admet-1209	25	26	a	a	DET
admet-1209	25	27	recent	recent	ADJ
admet-1209	25	28	phase	phase	NOUN
admet-1209	25	29	1	1	NUM
admet-1209	25	30	study	study	NOUN
admet-1209	25	31	show	show	VERB
admet-1209	25	32	that	that	SCONJ
admet-1209	25	33	the	the	DET
admet-1209	25	34	degrader	degrad	ADJ
admet-1209	25	35	principle	principle	NOUN
admet-1209	25	36	appears	appear	VERB
admet-1209	25	37	to	to	PART
admet-1209	25	38	work	work	VERB
admet-1209	25	39	in	in	ADP
admet-1209	25	40	humans	human	NOUN
admet-1209	25	41	[	[	X
admet-1209	25	42	12,13	12,13	NUM
admet-1209	25	43	]	]	PUNCT
admet-1209	25	44	.	.	PUNCT
admet-1209	26	1	colleagues	colleague	NOUN
admet-1209	26	2	from	from	ADP
admet-1209	26	3	the	the	DET
admet-1209	26	4	russian	russian	ADJ
admet-1209	26	5	academy	academy	PROPN
admet-1209	26	6	of	of	ADP
admet-1209	26	7	sciences	sciences	PROPN
admet-1209	26	8	in	in	ADP
admet-1209	26	9	saratov	saratov	PROPN
admet-1209	26	10	describe	describe	VERB
admet-1209	26	11	how	how	SCONJ
admet-1209	26	12	selenium	selenium	NOUN
admet-1209	26	13	nanoparticles	nanoparticle	NOUN
admet-1209	26	14	(	(	PUNCT
admet-1209	26	15	senps	senps	NOUN
admet-1209	26	16	)	)	PUNCT
admet-1209	26	17	can	can	AUX
admet-1209	26	18	be	be	AUX
admet-1209	26	19	used	use	VERB
admet-1209	26	20	to	to	PART
admet-1209	26	21	increase	increase	VERB
admet-1209	26	22	the	the	DET
admet-1209	26	23	bioavailability	bioavailability	NOUN
admet-1209	26	24	of	of	ADP
admet-1209	26	25	silymarin	silymarin	NOUN
admet-1209	27	1	[	[	X
admet-1209	27	2	14	14	NUM
admet-1209	27	3	]	]	X
admet-1209	27	4	,	,	PUNCT
admet-1209	27	5	a	a	DET
admet-1209	27	6	drug	drug	NOUN
admet-1209	27	7	with	with	ADP
admet-1209	27	8	discussed	discuss	VERB
admet-1209	27	9	liver	liver	NOUN
admet-1209	27	10	-	-	PUNCT
admet-1209	27	11	protective	protective	ADJ
admet-1209	27	12	and	and	CCONJ
admet-1209	27	13	anti	anti	ADJ
admet-1209	27	14	-	-	ADJ
admet-1209	27	15	cancer	cancer	ADJ
admet-1209	27	16	activity	activity	NOUN
admet-1209	27	17	[	[	X
admet-1209	27	18	15	15	NUM
admet-1209	27	19	]	]	PUNCT
admet-1209	27	20	but	but	CCONJ
admet-1209	27	21	unfavorable	unfavorable	ADJ
admet-1209	27	22	physicochemical	physicochemical	ADJ
admet-1209	27	23	properties	property	NOUN
admet-1209	27	24	.	.	PUNCT
admet-1209	28	1	by	by	ADP
admet-1209	28	2	combining	combine	VERB
admet-1209	28	3	the	the	DET
admet-1209	28	4	anti	anti	ADJ
admet-1209	28	5	-	-	ADJ
admet-1209	28	6	cancer	cancer	ADJ
admet-1209	28	7	activity	activity	NOUN
admet-1209	28	8	of	of	ADP
admet-1209	28	9	senps	senps	NOUN
admet-1209	28	10	with	with	ADP
admet-1209	28	11	the	the	DET
admet-1209	28	12	effect	effect	NOUN
admet-1209	28	13	of	of	ADP
admet-1209	28	14	poorly	poorly	ADV
admet-1209	28	15	soluble	soluble	ADJ
admet-1209	28	16	silymarin	silymarin	NOUN
admet-1209	28	17	,	,	PUNCT
admet-1209	28	18	the	the	DET
admet-1209	28	19	in	in	ADV
admet-1209	28	20	vitro	vitro	X
admet-1209	28	21	activity	activity	NOUN
admet-1209	28	22	could	could	AUX
admet-1209	28	23	be	be	AUX
admet-1209	28	24	increased	increase	VERB
admet-1209	28	25	and	and	CCONJ
admet-1209	28	26	the	the	DET
admet-1209	28	27	side	side	NOUN
admet-1209	28	28	effects	effect	NOUN
admet-1209	28	29	of	of	ADP
admet-1209	28	30	se	se	X
admet-1209	28	31	could	could	AUX
admet-1209	28	32	be	be	AUX
admet-1209	28	33	partially	partially	ADV
admet-1209	28	34	alleviated	alleviate	VERB
admet-1209	28	35	.	.	PUNCT
admet-1209	29	1	this	this	PRON
admet-1209	29	2	can	can	AUX
admet-1209	29	3	be	be	AUX
admet-1209	29	4	considered	consider	VERB
admet-1209	29	5	a	a	DET
admet-1209	29	6	good	good	ADJ
admet-1209	29	7	example	example	NOUN
admet-1209	29	8	of	of	ADP
admet-1209	29	9	how	how	SCONJ
admet-1209	29	10	the	the	DET
admet-1209	29	11	therapeutic	therapeutic	ADJ
admet-1209	29	12	effects	effect	NOUN
admet-1209	29	13	and	and	CCONJ
admet-1209	29	14	side	side	NOUN
admet-1209	29	15	effects	effect	NOUN
admet-1209	29	16	of	of	ADP
admet-1209	29	17	np	np	PRON
admet-1209	29	18	can	can	AUX
admet-1209	29	19	be	be	AUX
admet-1209	29	20	potentially	potentially	ADV
admet-1209	29	21	controlled	control	VERB
admet-1209	29	22	by	by	ADP
admet-1209	29	23	combining	combine	VERB
admet-1209	29	24	drugs	drug	NOUN
admet-1209	29	25	in	in	ADP
admet-1209	29	26	nps	nps	PROPN
admet-1209	29	27	in	in	ADP
admet-1209	29	28	the	the	DET
admet-1209	29	29	future	future	NOUN
admet-1209	29	30	.	.	PUNCT
admet-1209	30	1	in	in	ADP
admet-1209	30	2	addition	addition	NOUN
admet-1209	30	3	to	to	ADP
admet-1209	30	4	new	new	ADJ
admet-1209	30	5	therapeutic	therapeutic	ADJ
admet-1209	30	6	principles	principle	NOUN
admet-1209	30	7	,	,	PUNCT
admet-1209	30	8	innovative	innovative	ADJ
admet-1209	30	9	new	new	ADJ
admet-1209	30	10	methods	method	NOUN
admet-1209	30	11	for	for	ADP
admet-1209	30	12	testing	testing	NOUN
admet-1209	30	13	and	and	CCONJ
admet-1209	30	14	optimizing	optimize	VERB
admet-1209	30	15	drug	drug	NOUN
admet-1209	30	16	safety	safety	NOUN
admet-1209	30	17	are	be	AUX
admet-1209	30	18	urgently	urgently	ADV
admet-1209	30	19	needed	need	VERB
admet-1209	30	20	.	.	PUNCT
admet-1209	31	1	in	in	ADP
admet-1209	31	2	a	a	DET
admet-1209	31	3	fascinating	fascinating	ADJ
admet-1209	31	4	mini	mini	NOUN
admet-1209	31	5	-	-	NOUN
admet-1209	31	6	review	review	NOUN
admet-1209	31	7	[	[	X
admet-1209	31	8	16	16	NUM
admet-1209	31	9	]	]	X
admet-1209	31	10	,	,	PUNCT
admet-1209	31	11	a	a	DET
admet-1209	31	12	joint	joint	ADJ
admet-1209	31	13	team	team	NOUN
admet-1209	31	14	of	of	ADP
admet-1209	31	15	experts	expert	NOUN
admet-1209	31	16	from	from	ADP
admet-1209	31	17	academia	academia	NOUN
admet-1209	31	18	in	in	ADP
admet-1209	31	19	australia	australia	PROPN
admet-1209	31	20	and	and	CCONJ
admet-1209	31	21	the	the	DET
admet-1209	31	22	pharmaceutical	pharmaceutical	NOUN
admet-1209	31	23	industry	industry	NOUN
admet-1209	31	24	in	in	ADP
admet-1209	31	25	switzerland	switzerland	PROPN
admet-1209	31	26	described	describe	VERB
admet-1209	31	27	how	how	SCONJ
admet-1209	31	28	3d	3d	PROPN
admet-1209	31	29	bioprinted	bioprinte	VERB
admet-1209	31	30	heart	heart	NOUN
admet-1209	31	31	cells	cell	NOUN
admet-1209	31	32	could	could	AUX
admet-1209	31	33	be	be	AUX
admet-1209	31	34	strategically	strategically	ADV
admet-1209	31	35	used	use	VERB
admet-1209	31	36	in	in	ADP
admet-1209	31	37	pharmaceutical	pharmaceutical	ADJ
admet-1209	31	38	research	research	NOUN
admet-1209	31	39	and	and	CCONJ
admet-1209	31	40	development	development	NOUN
admet-1209	31	41	and	and	CCONJ
admet-1209	31	42	potentially	potentially	ADV
admet-1209	31	43	improve	improve	VERB
admet-1209	31	44	and	and	CCONJ
admet-1209	31	45	streamline	streamline	VERB
admet-1209	31	46	regulatory	regulatory	ADJ
admet-1209	31	47	processes	process	NOUN
admet-1209	31	48	.	.	PUNCT
admet-1209	32	1	finally	finally	ADV
admet-1209	32	2	,	,	PUNCT
admet-1209	32	3	a	a	DET
admet-1209	32	4	team	team	NOUN
admet-1209	32	5	of	of	ADP
admet-1209	32	6	experts	expert	NOUN
admet-1209	32	7	from	from	ADP
admet-1209	32	8	the	the	DET
admet-1209	32	9	universities	university	NOUN
admet-1209	32	10	of	of	ADP
admet-1209	32	11	naples	naples	PROPN
admet-1209	32	12	and	and	CCONJ
admet-1209	32	13	edinburgh	edinburgh	PROPN
admet-1209	32	14	describes	describe	VERB
admet-1209	32	15	the	the	DET
admet-1209	32	16	development	development	NOUN
admet-1209	32	17	of	of	ADP
admet-1209	32	18	in	in	ADP
admet-1209	32	19	silico	silico	NOUN
admet-1209	32	20	prediction	prediction	NOUN
admet-1209	32	21	models	model	NOUN
admet-1209	32	22	based	base	VERB
admet-1209	32	23	on	on	ADP
admet-1209	32	24	immobilized	immobilized	ADJ
admet-1209	32	25	artificial	artificial	ADJ
admet-1209	32	26	membrane	membrane	NOUN
admet-1209	32	27	(	(	PUNCT
admet-1209	32	28	iam	iam	PROPN
admet-1209	32	29	)	)	PUNCT
admet-1209	32	30	chromatography	chromatography	NOUN
admet-1209	32	31	measurements	measurement	NOUN
admet-1209	32	32	and	and	CCONJ
admet-1209	32	33	predicted	predict	VERB
admet-1209	32	34	drug	drug	NOUN
admet-1209	32	35	properties	property	NOUN
admet-1209	32	36	to	to	PART
admet-1209	32	37	estimate	estimate	VERB
admet-1209	32	38	the	the	DET
admet-1209	32	39	blood	blood	NOUN
admet-1209	32	40	-	-	PUNCT
admet-1209	32	41	brain	brain	NOUN
admet-1209	32	42	barrier	barrier	NOUN
admet-1209	32	43	passage	passage	NOUN
admet-1209	32	44	of	of	ADP
admet-1209	32	45	drugs	drug	NOUN
admet-1209	32	46	[	[	X
admet-1209	32	47	17	17	NUM
admet-1209	32	48	]	]	PUNCT
admet-1209	32	49	.	.	PUNCT
admet-1209	33	1	although	although	SCONJ
admet-1209	33	2	the	the	DET
admet-1209	33	3	admet	admet	PROPN
admet-1209	33	4	&	&	CCONJ
admet-1209	33	5	dmpk	dmpk	PROPN
admet-1209	33	6	9(4	9(4	PROPN
admet-1209	33	7	)	)	PUNCT
admet-1209	33	8	(	(	PUNCT
admet-1209	33	9	2021	2021	NUM
admet-1209	33	10	)	)	PUNCT
admet-1209	33	11	227	227	NUM
admet-1209	33	12	-	-	SYM
admet-1209	33	13	230	230	NUM
admet-1209	33	14	editorial	editorial	NOUN
admet-1209	33	15	:	:	PUNCT
admet-1209	33	16	new	new	ADJ
admet-1209	33	17	therapeutic	therapeutic	ADJ
admet-1209	33	18	modalities	modality	NOUN
admet-1209	33	19	in	in	ADP
admet-1209	33	20	ddd	ddd	NOUN
admet-1209	33	21	doi	doi	NOUN
admet-1209	33	22	:	:	PUNCT
admet-1209	33	23	http://doi.org/10.5599/admet.1209	http://doi.org/10.5599/admet.1209	NOUN
admet-1209	33	24	229	229	NUM
admet-1209	33	25	method	method	NOUN
admet-1209	33	26	is	be	AUX
admet-1209	33	27	premature	premature	ADJ
admet-1209	33	28	,	,	PUNCT
admet-1209	33	29	due	due	ADP
admet-1209	33	30	to	to	ADP
admet-1209	33	31	the	the	DET
admet-1209	33	32	currently	currently	ADV
admet-1209	33	33	limited	limit	VERB
admet-1209	33	34	amount	amount	NOUN
admet-1209	33	35	of	of	ADP
admet-1209	33	36	data	datum	NOUN
admet-1209	33	37	,	,	PUNCT
admet-1209	33	38	it	it	PRON
admet-1209	33	39	might	might	AUX
admet-1209	33	40	be	be	AUX
admet-1209	33	41	applied	apply	VERB
admet-1209	33	42	in	in	ADP
admet-1209	33	43	drug	drug	NOUN
admet-1209	33	44	discovery	discovery	NOUN
admet-1209	33	45	and	and	CCONJ
admet-1209	33	46	development	development	NOUN
admet-1209	33	47	in	in	ADP
admet-1209	33	48	selecting	select	VERB
admet-1209	33	49	appropriate	appropriate	ADJ
admet-1209	33	50	drug	drug	NOUN
admet-1209	33	51	candidates	candidate	NOUN
admet-1209	33	52	with	with	ADP
admet-1209	33	53	improved	improved	ADJ
admet-1209	33	54	brain	brain	NOUN
admet-1209	33	55	penetration	penetration	NOUN
admet-1209	33	56	properties	property	NOUN
admet-1209	33	57	in	in	ADP
admet-1209	33	58	the	the	DET
admet-1209	33	59	future	future	NOUN
admet-1209	33	60	.	.	PUNCT
admet-1209	34	1	overall	overall	ADV
admet-1209	34	2	,	,	PUNCT
admet-1209	34	3	this	this	DET
admet-1209	34	4	special	special	ADJ
admet-1209	34	5	issue	issue	NOUN
admet-1209	34	6	of	of	ADP
admet-1209	34	7	admet	admet	PROPN
admet-1209	34	8	and	and	CCONJ
admet-1209	34	9	dmpk	dmpk	NOUN
admet-1209	34	10	provides	provide	VERB
admet-1209	34	11	interesting	interesting	ADJ
admet-1209	34	12	insights	insight	NOUN
admet-1209	34	13	into	into	ADP
admet-1209	34	14	selected	select	VERB
admet-1209	34	15	innovative	innovative	ADJ
admet-1209	34	16	areas	area	NOUN
admet-1209	34	17	of	of	ADP
admet-1209	34	18	drug	drug	NOUN
admet-1209	34	19	discovery	discovery	NOUN
admet-1209	34	20	and	and	CCONJ
admet-1209	34	21	development	development	NOUN
admet-1209	34	22	.	.	PUNCT
admet-1209	35	1	references	reference	NOUN
admet-1209	35	2	[	[	X
admet-1209	35	3	1	1	NUM
admet-1209	35	4	]	]	X
admet-1209	35	5	i.m	i.m	PROPN
admet-1209	35	6	.	.	PROPN
admet-1209	35	7	cockburn	cockburn	PROPN
admet-1209	35	8	.	.	PUNCT
admet-1209	36	1	is	be	AUX
admet-1209	36	2	the	the	DET
admet-1209	36	3	pharmaceutical	pharmaceutical	ADJ
admet-1209	36	4	industry	industry	NOUN
admet-1209	36	5	in	in	ADP
admet-1209	36	6	a	a	DET
admet-1209	36	7	productivity	productivity	NOUN
admet-1209	36	8	crisis	crisis	NOUN
admet-1209	36	9	?	?	PUNCT
admet-1209	36	10	.	.	PUNCT
admet-1209	37	1	innovation	innovation	NOUN
admet-1209	37	2	policy	policy	NOUN
admet-1209	37	3	and	and	CCONJ
admet-1209	37	4	the	the	DET
admet-1209	37	5	economy	economy	NOUN
admet-1209	37	6	7	7	NUM
admet-1209	37	7	(	(	PUNCT
admet-1209	37	8	2006	2006	NUM
admet-1209	37	9	)	)	PUNCT
admet-1209	37	10	1–32	1–32	NOUN
admet-1209	37	11	.	.	PUNCT
admet-1209	38	1	https://doi.org/10.1086/ipe.7.25056188	https://doi.org/10.1086/ipe.7.25056188	VERB
admet-1209	38	2	.	.	PUNCT
admet-1209	39	1	[	[	X
admet-1209	39	2	2	2	NUM
admet-1209	39	3	]	]	PUNCT
admet-1209	39	4	a.	a.	NOUN
admet-1209	39	5	schuhmacher	schuhmacher	PROPN
admet-1209	39	6	,	,	PUNCT
admet-1209	39	7	o.	o.	PROPN
admet-1209	39	8	grassmann	grassmann	PROPN
admet-1209	39	9	,	,	PUNCT
admet-1209	39	10	m.	m.	NOUN
admet-1209	39	11	hinder	hinder	NOUN
admet-1209	39	12	.	.	PUNCT
admet-1209	40	1	changing	change	VERB
admet-1209	40	2	r&d	r&d	NOUN
admet-1209	40	3	models	model	NOUN
admet-1209	40	4	in	in	ADP
admet-1209	40	5	research	research	NOUN
admet-1209	40	6	-	-	PUNCT
admet-1209	40	7	based	base	VERB
admet-1209	40	8	pharmaceutical	pharmaceutical	ADJ
admet-1209	40	9	companies	company	NOUN
admet-1209	40	10	.	.	PUNCT
admet-1209	41	1	journal	journal	PROPN
admet-1209	41	2	of	of	ADP
admet-1209	41	3	translational	translational	ADJ
admet-1209	41	4	medicine	medicine	NOUN
admet-1209	41	5	14	14	NUM
admet-1209	41	6	(	(	PUNCT
admet-1209	41	7	2016)105	2016)105	NUM
admet-1209	41	8	-	-	PUNCT
admet-1209	41	9	116	116	NUM
admet-1209	41	10	.	.	PUNCT
admet-1209	42	1	https://doi.org/10.1186/s12967016-0838-4	https://doi.org/10.1186/s12967016-0838-4	PROPN
admet-1209	42	2	.	.	PUNCT
admet-1209	43	1	[	[	X
admet-1209	43	2	3	3	X
admet-1209	43	3	]	]	X
admet-1209	43	4	f.	f.	PROPN
admet-1209	43	5	pamolli	pamolli	PROPN
admet-1209	43	6	,	,	PUNCT
admet-1209	43	7	l.	l.	PROPN
admet-1209	43	8	magazzini	magazzini	PROPN
admet-1209	43	9	,	,	PUNCT
admet-1209	43	10	m.	m.	NOUN
admet-1209	43	11	riccaboni	riccaboni	NOUN
admet-1209	43	12	.	.	PUNCT
admet-1209	44	1	the	the	DET
admet-1209	44	2	productivity	productivity	NOUN
admet-1209	44	3	crisis	crisis	NOUN
admet-1209	44	4	in	in	ADP
admet-1209	44	5	pharma	pharma	PROPN
admet-1209	44	6	r	r	PROPN
admet-1209	44	7	&	&	CCONJ
admet-1209	44	8	d.	d.	PROPN
admet-1209	44	9	nature	nature	PROPN
admet-1209	44	10	reviews	review	VERB
admet-1209	44	11	in	in	ADP
admet-1209	44	12	drug	drug	NOUN
admet-1209	44	13	discovery	discovery	NOUN
admet-1209	44	14	10	10	NUM
admet-1209	44	15	(	(	PUNCT
admet-1209	44	16	2011	2011	NUM
admet-1209	44	17	)	)	PUNCT
admet-1209	44	18	428	428	NUM
admet-1209	44	19	-	-	SYM
admet-1209	44	20	438	438	NUM
admet-1209	44	21	.	.	PUNCT
admet-1209	45	1	https://doi.org/10.1038/nrd3405	https://doi.org/10.1038/nrd3405	PROPN
admet-1209	45	2	.	.	PUNCT
admet-1209	46	1	[	[	X
admet-1209	46	2	4	4	X
admet-1209	46	3	]	]	X
admet-1209	46	4	y.	y.	PROPN
admet-1209	46	5	feyman	feyman	PROPN
admet-1209	46	6	.	.	PUNCT
admet-1209	46	7	is	be	AUX
admet-1209	46	8	pharmaceutical	pharmaceutical	ADJ
admet-1209	46	9	productivity	productivity	NOUN
admet-1209	46	10	in	in	ADP
admet-1209	46	11	decline	decline	NOUN
admet-1209	46	12	?	?	PUNCT
admet-1209	47	1	maybe	maybe	ADV
admet-1209	47	2	not	not	PART
admet-1209	47	3	.	.	PUNCT
admet-1209	48	1	forbes	forbes	PROPN
admet-1209	48	2	.	.	PUNCT
admet-1209	49	1	april	april	PROPN
admet-1209	49	2	13	13	NUM
admet-1209	49	3	,	,	PUNCT
admet-1209	49	4	2015	2015	NUM
admet-1209	49	5	.	.	PUNCT
admet-1209	50	1	https://www.forbes.com/sites/theapothecary/2015/04/13/is-pharmaceutical-productivity-indecline-maybe-not/.	https://www.forbes.com/sites/theapothecary/2015/04/13/is-pharmaceutical-productivity-indecline-maybe-not/.	PROPN
admet-1209	51	1	[	[	X
admet-1209	51	2	5	5	X
admet-1209	51	3	]	]	X
admet-1209	51	4	k.j	k.j	PROPN
admet-1209	51	5	.	.	PROPN
admet-1209	51	6	hult	hult	PROPN
admet-1209	51	7	.	.	PUNCT
admet-1209	52	1	economics	economic	NOUN
admet-1209	52	2	,	,	PUNCT
admet-1209	52	3	2015	2015	NUM
admet-1209	52	4	.	.	PUNCT
admet-1209	53	1	incremental	incremental	ADJ
admet-1209	53	2	innovation	innovation	NOUN
admet-1209	53	3	and	and	CCONJ
admet-1209	53	4	pharmaceutical	pharmaceutical	NOUN
admet-1209	53	5	productivity	productivity	NOUN
admet-1209	53	6	.	.	PUNCT
admet-1209	54	1	http://terramedica.hsinetwork.com/hult%20%20incremental%20innovation%20and%20pharmaceutical%20productivity.pdf	http://terramedica.hsinetwork.com/hult%20%20incremental%20innovation%20and%20pharmaceutical%20productivity.pdf	PROPN
admet-1209	54	2	.	.	PUNCT
admet-1209	55	1	[	[	X
admet-1209	55	2	6	6	NUM
admet-1209	55	3	]	]	SYM
admet-1209	55	4	u.s.food	u.s.food	ADJ
admet-1209	55	5	and	and	CCONJ
admet-1209	55	6	drug	drug	NOUN
admet-1209	55	7	administration	administration	NOUN
admet-1209	55	8	website	website	NOUN
admet-1209	55	9	.	.	PUNCT
admet-1209	56	1	https://www.fda.gov/drugs/drug-approvals-anddatabases/compilation-cder-new-molecular-entity-nme-drug-and-new-biologic-approvals	https://www.fda.gov/drugs/drug-approvals-anddatabases/compilation-cder-new-molecular-entity-nme-drug-and-new-biologic-approval	NOUN
admet-1209	56	2	(	(	PUNCT
admet-1209	56	3	status	status	NOUN
admet-1209	56	4	29/11/2021	29/11/2021	NUM
admet-1209	56	5	)	)	PUNCT
admet-1209	56	6	.	.	PUNCT
admet-1209	57	1	[	[	X
admet-1209	57	2	7	7	X
admet-1209	57	3	]	]	X
admet-1209	57	4	c.	c.	PROPN
admet-1209	57	5	lipinski	lipinski	PROPN
admet-1209	57	6	,	,	PUNCT
admet-1209	57	7	f.	f.	PROPN
admet-1209	57	8	lombardo	lombardo	PROPN
admet-1209	57	9	,	,	PUNCT
admet-1209	57	10	b.	b.	PROPN
admet-1209	57	11	dominy	dominy	PROPN
admet-1209	57	12	,	,	PUNCT
admet-1209	57	13	p.	p.	PROPN
admet-1209	57	14	feeney	feeney	PROPN
admet-1209	57	15	.	.	PUNCT
admet-1209	58	1	experimental	experimental	ADJ
admet-1209	58	2	and	and	CCONJ
admet-1209	58	3	computational	computational	ADJ
admet-1209	58	4	approaches	approach	NOUN
admet-1209	58	5	to	to	PART
admet-1209	58	6	estimate	estimate	VERB
admet-1209	58	7	solubility	solubility	NOUN
admet-1209	58	8	and	and	CCONJ
admet-1209	58	9	permeability	permeability	NOUN
admet-1209	58	10	in	in	ADP
admet-1209	58	11	drug	drug	NOUN
admet-1209	58	12	discovery	discovery	NOUN
admet-1209	58	13	and	and	CCONJ
admet-1209	58	14	development	development	NOUN
admet-1209	58	15	settings	setting	NOUN
admet-1209	58	16	.	.	PUNCT
admet-1209	59	1	advances	advance	NOUN
admet-1209	59	2	in	in	ADP
admet-1209	59	3	drug	drug	NOUN
admet-1209	59	4	delivery	delivery	NOUN
admet-1209	59	5	reviews	review	VERB
admet-1209	59	6	23	23	NUM
admet-1209	59	7	(	(	PUNCT
admet-1209	59	8	1997	1997	NUM
admet-1209	59	9	)	)	PUNCT
admet-1209	59	10	3	3	NUM
admet-1209	59	11	-	-	SYM
admet-1209	59	12	25	25	NUM
admet-1209	59	13	.	.	PUNCT
admet-1209	60	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
admet-1209	60	2	.	.	PUNCT
admet-1209	61	1	[	[	X
admet-1209	61	2	8	8	NUM
admet-1209	61	3	]	]	PUNCT
admet-1209	61	4	a.	a.	NOUN
admet-1209	61	5	avdeef	avdeef	PROPN
admet-1209	61	6	,	,	PUNCT
admet-1209	61	7	m.	m.	PROPN
admet-1209	61	8	kansy	kansy	PROPN
admet-1209	61	9	.	.	PUNCT
admet-1209	62	1	“	"	PUNCT
admet-1209	62	2	flexible	flexible	ADJ
admet-1209	62	3	-	-	PUNCT
admet-1209	62	4	acceptor	acceptor	NOUN
admet-1209	62	5	”	"	PUNCT
admet-1209	62	6	general	general	ADJ
admet-1209	62	7	solubility	solubility	NOUN
admet-1209	62	8	equation	equation	NOUN
admet-1209	62	9	for	for	ADP
admet-1209	62	10	beyond	beyond	ADP
admet-1209	62	11	rule	rule	NOUN
admet-1209	62	12	of	of	ADP
admet-1209	62	13	5	5	NUM
admet-1209	62	14	drugs	drug	NOUN
admet-1209	62	15	.	.	PUNCT
admet-1209	63	1	molecular	molecular	ADJ
admet-1209	63	2	pharmaceutics	pharmaceutic	NOUN
admet-1209	63	3	17	17	NUM
admet-1209	63	4	(	(	PUNCT
admet-1209	63	5	2020	2020	NUM
admet-1209	63	6	)	)	PUNCT
admet-1209	63	7	3930–3940	3930–3940	NUM
admet-1209	63	8	.	.	PUNCT
admet-1209	64	1	https://doi.org/10.1021/acs.molpharmaceut.0c00689	https://doi.org/10.1021/acs.molpharmaceut.0c00689	X
admet-1209	64	2	.	.	PUNCT
admet-1209	65	1	[	[	X
admet-1209	65	2	9	9	NUM
admet-1209	65	3	]	]	PUNCT
admet-1209	65	4	m.	m.	NOUN
admet-1209	65	5	rossi	rossi	PROPN
admet-1209	65	6	sebastiano	sebastiano	PROPN
admet-1209	65	7	,	,	PUNCT
admet-1209	65	8	b.c	b.c	PROPN
admet-1209	65	9	.	.	PROPN
admet-1209	65	10	doak	doak	PROPN
admet-1209	65	11	,	,	PUNCT
admet-1209	65	12	m.	m.	NOUN
admet-1209	65	13	backlund	backlund	PROPN
admet-1209	65	14	,	,	PUNCT
admet-1209	65	15	v.	v.	ADP
admet-1209	65	16	poongavanam	poongavanam	PROPN
admet-1209	65	17	,	,	PUNCT
admet-1209	65	18	b.	b.	PROPN
admet-1209	65	19	over	over	PROPN
admet-1209	65	20	,	,	PUNCT
admet-1209	65	21	g.	g.	PROPN
admet-1209	65	22	ermondi	ermondi	PROPN
admet-1209	65	23	,	,	PUNCT
admet-1209	65	24	g.	g.	PROPN
admet-1209	65	25	caron	caron	PROPN
admet-1209	65	26	,	,	PUNCT
admet-1209	65	27	p.	p.	PROPN
admet-1209	65	28	matsson	matsson	PROPN
admet-1209	65	29	,	,	PUNCT
admet-1209	65	30	j.	j.	PROPN
admet-1209	65	31	kihlberg	kihlberg	PROPN
admet-1209	65	32	.	.	PUNCT
admet-1209	66	1	impact	impact	NOUN
admet-1209	66	2	of	of	ADP
admet-1209	66	3	dynamically	dynamically	ADV
admet-1209	66	4	exposed	expose	VERB
admet-1209	66	5	polarity	polarity	NOUN
admet-1209	66	6	on	on	ADP
admet-1209	66	7	permeability	permeability	NOUN
admet-1209	66	8	and	and	CCONJ
admet-1209	66	9	solubility	solubility	NOUN
admet-1209	66	10	of	of	ADP
admet-1209	66	11	chameleonic	chameleonic	ADJ
admet-1209	66	12	drugs	drug	NOUN
admet-1209	66	13	beyond	beyond	ADP
admet-1209	66	14	the	the	DET
admet-1209	66	15	rule	rule	NOUN
admet-1209	66	16	of	of	ADP
admet-1209	66	17	5	5	NUM
admet-1209	66	18	.	.	PUNCT
admet-1209	66	19	journal	journal	PROPN
admet-1209	66	20	of	of	ADP
admet-1209	66	21	medicinal	medicinal	ADJ
admet-1209	66	22	chemistry	chemistry	NOUN
admet-1209	66	23	61	61	NUM
admet-1209	66	24	(	(	PUNCT
admet-1209	66	25	2018	2018	NUM
admet-1209	66	26	)	)	PUNCT
admet-1209	66	27	4189–4202	4189–4202	NUM
admet-1209	66	28	.	.	PUNCT
admet-1209	67	1	https://doi.org/10.1021/acs.jmedchem.8b00347	https://doi.org/10.1021/acs.jmedchem.8b00347	ADJ
admet-1209	67	2	.	.	PUNCT
admet-1209	68	1	[	[	X
admet-1209	68	2	10	10	NUM
admet-1209	68	3	]	]	X
admet-1209	68	4	g.	g.	PROPN
admet-1209	68	5	caron	caron	PROPN
admet-1209	68	6	,	,	PUNCT
admet-1209	68	7	g.	g.	PROPN
admet-1209	68	8	ermondi	ermondi	PROPN
admet-1209	68	9	.	.	PUNCT
admet-1209	69	1	molecular	molecular	ADJ
admet-1209	69	2	descriptors	descriptor	NOUN
admet-1209	69	3	for	for	ADP
admet-1209	69	4	polarity	polarity	NOUN
admet-1209	69	5	:	:	PUNCT
admet-1209	69	6	the	the	DET
admet-1209	69	7	need	need	NOUN
admet-1209	69	8	for	for	ADP
admet-1209	69	9	going	go	VERB
admet-1209	69	10	beyond	beyond	ADP
admet-1209	69	11	polar	polar	ADJ
admet-1209	69	12	surface	surface	NOUN
admet-1209	69	13	area	area	NOUN
admet-1209	69	14	.	.	PUNCT
admet-1209	70	1	future	future	ADJ
admet-1209	70	2	medicinal	medicinal	ADJ
admet-1209	70	3	chemistry	chemistry	NOUN
admet-1209	70	4	8	8	NUM
admet-1209	70	5	(	(	PUNCT
admet-1209	70	6	2016	2016	NUM
admet-1209	70	7	)	)	PUNCT
admet-1209	70	8	2013	2013	NUM
admet-1209	70	9	-	-	SYM
admet-1209	70	10	2016	2016	NUM
admet-1209	70	11	.	.	PUNCT
admet-1209	70	12	https://doi.org/10.4155/fmc-2016-0165	https://doi.org/10.4155/fmc-2016-0165	NOUN
admet-1209	70	13	.	.	PUNCT
admet-1209	71	1	[	[	X
admet-1209	71	2	11	11	NUM
admet-1209	71	3	]	]	X
admet-1209	71	4	d.g	d.g	PROPN
admet-1209	71	5	.	.	PROPN
admet-1209	71	6	jimenez	jimenez	PROPN
admet-1209	71	7	,	,	PUNCT
admet-1209	71	8	m.r	m.r	PROPN
admet-1209	71	9	.	.	PROPN
admet-1209	71	10	sebastiano	sebastiano	PROPN
admet-1209	71	11	,	,	PUNCT
admet-1209	71	12	g.	g.	PROPN
admet-1209	71	13	caron	caron	PROPN
admet-1209	71	14	,	,	PUNCT
admet-1209	71	15	g.	g.	PROPN
admet-1209	71	16	ermondi	ermondi	PROPN
admet-1209	71	17	.	.	PUNCT
admet-1209	72	1	are	be	AUX
admet-1209	72	2	we	we	PRON
admet-1209	72	3	ready	ready	ADJ
admet-1209	72	4	to	to	PART
admet-1209	72	5	design	design	VERB
admet-1209	72	6	oral	oral	ADJ
admet-1209	72	7	protacs	protac	NOUN
admet-1209	72	8	®	®	NOUN
admet-1209	72	9	?	?	PUNCT
admet-1209	72	10	.	.	PUNCT
admet-1209	73	1	admet	admet	PROPN
admet-1209	73	2	and	and	CCONJ
admet-1209	73	3	dmpk	dmpk	X
admet-1209	73	4	9	9	NUM
admet-1209	73	5	(	(	PUNCT
admet-1209	73	6	2021	2021	NUM
admet-1209	73	7	)	)	PUNCT
admet-1209	73	8	243	243	NUM
admet-1209	73	9	-	-	SYM
admet-1209	73	10	254	254	NUM
admet-1209	73	11	.	.	PUNCT
admet-1209	74	1	https://doi.org/10.5599/admet.1037	https://doi.org/10.5599/admet.1037	NOUN
admet-1209	74	2	.	.	PUNCT
admet-1209	75	1	[	[	X
admet-1209	75	2	12	12	NUM
admet-1209	75	3	]	]	PUNCT
admet-1209	75	4	a.	a.	NOUN
admet-1209	75	5	mullard	mullard	PROPN
admet-1209	75	6	.	.	PUNCT
admet-1209	76	1	targeted	target	VERB
admet-1209	76	2	degraders	degrader	NOUN
admet-1209	76	3	clear	clear	ADJ
admet-1209	76	4	first	first	ADJ
admet-1209	76	5	safety	safety	NOUN
admet-1209	76	6	hurdles	hurdle	NOUN
admet-1209	76	7	.	.	PUNCT
admet-1209	77	1	nature	nature	NOUN
admet-1209	77	2	reviews	review	VERB
admet-1209	77	3	drug	drug	NOUN
admet-1209	77	4	discovery	discovery	NOUN
admet-1209	77	5	19	19	NUM
admet-1209	77	6	(	(	PUNCT
admet-1209	77	7	2020	2020	NUM
admet-1209	77	8	)	)	PUNCT
admet-1209	77	9	435	435	NUM
admet-1209	77	10	.	.	PUNCT
admet-1209	78	1	https://doi.org/10.1038/d41573-020-00109-w	https://doi.org/10.1038/d41573-020-00109-w	NOUN
admet-1209	78	2	.	.	PUNCT
admet-1209	79	1	[	[	X
admet-1209	79	2	13	13	NUM
admet-1209	79	3	]	]	PUNCT
admet-1209	79	4	a.	a.	NOUN
admet-1209	79	5	mullard	mullard	PROPN
admet-1209	79	6	.	.	PUNCT
admet-1209	80	1	targeted	target	VERB
admet-1209	80	2	protein	protein	NOUN
admet-1209	80	3	degraders	degrader	NOUN
admet-1209	80	4	crowd	crowd	VERB
admet-1209	80	5	into	into	ADP
admet-1209	80	6	clinic	clinic	NOUN
admet-1209	80	7	.	.	PUNCT
admet-1209	81	1	nature	nature	NOUN
admet-1209	81	2	reviews	review	VERB
admet-1209	81	3	drug	drug	NOUN
admet-1209	81	4	discovery	discovery	NOUN
admet-1209	81	5	20	20	NUM
admet-1209	81	6	(	(	PUNCT
admet-1209	81	7	2020	2020	NUM
admet-1209	81	8	)	)	PUNCT
admet-1209	81	9	247	247	NUM
admet-1209	81	10	-	-	SYM
admet-1209	81	11	250	250	NUM
admet-1209	81	12	.	.	PUNCT
admet-1209	82	1	https://doi.org/10.1038/d41573-021-00052-4	https://doi.org/10.1038/d41573-021-00052-4	NUM
admet-1209	82	2	.	.	PUNCT
admet-1209	83	1	[	[	X
admet-1209	83	2	14	14	NUM
admet-1209	83	3	]	]	X
admet-1209	83	4	s.	s.	PROPN
admet-1209	83	5	staroverov	staroverov	PROPN
admet-1209	83	6	,	,	PUNCT
admet-1209	83	7	s.	s.	PROPN
admet-1209	83	8	kozlov	kozlov	PROPN
admet-1209	83	9	,	,	PUNCT
admet-1209	83	10	a.	a.	NOUN
admet-1209	83	11	fomin	fomin	PROPN
admet-1209	83	12	,	,	PUNCT
admet-1209	83	13	k.	k.	PROPN
admet-1209	83	14	gabalov	gabalov	PROPN
admet-1209	83	15	,	,	PUNCT
admet-1209	83	16	v.	v.	PROPN
admet-1209	83	17	khanadeev	khanadeev	PROPN
admet-1209	83	18	,	,	PUNCT
admet-1209	83	19	d.	d.	PROPN
admet-1209	83	20	soldatov	soldatov	PROPN
admet-1209	83	21	,	,	PUNCT
admet-1209	83	22	i.	i.	PROPN
admet-1209	83	23	domnitsky	domnitsky	PROPN
admet-1209	83	24	,	,	PUNCT
admet-1209	83	25	l.	l.	PROPN
admet-1209	83	26	dykman	dykman	PROPN
admet-1209	83	27	,	,	PUNCT
admet-1209	83	28	s.v	s.v	PROPN
admet-1209	83	29	.	.	PROPN
admet-1209	83	30	akchurin	akchurin	PROPN
admet-1209	83	31	,	,	PUNCT
admet-1209	83	32	o.	o.	PROPN
admet-1209	83	33	guliy	guliy	PROPN
admet-1209	83	34	.	.	PUNCT
admet-1209	84	1	synthesis	synthesis	NOUN
admet-1209	84	2	of	of	ADP
admet-1209	84	3	silymarin−selenium	silymarin−selenium	NOUN
admet-1209	84	4	nanoparticle	nanoparticle	NOUN
admet-1209	84	5	conjugate	conjugate	NOUN
admet-1209	84	6	and	and	CCONJ
admet-1209	84	7	examination	examination	NOUN
admet-1209	84	8	of	of	ADP
admet-1209	84	9	its	its	PRON
admet-1209	84	10	biological	biological	ADJ
admet-1209	84	11	activity	activity	NOUN
admet-1209	84	12	in	in	ADP
admet-1209	84	13	vitro	vitro	X
admet-1209	84	14	.	.	PUNCT
admet-1209	85	1	admet	admet	PROPN
admet-1209	85	2	and	and	CCONJ
admet-1209	85	3	dmpk	dmpk	X
admet-1209	85	4	9	9	NUM
admet-1209	85	5	(	(	PUNCT
admet-1209	85	6	2021	2021	NUM
admet-1209	85	7	)	)	PUNCT
admet-1209	85	8	255	255	NUM
admet-1209	85	9	-	-	SYM
admet-1209	85	10	266	266	NUM
admet-1209	85	11	.	.	PUNCT
admet-1209	85	12	https://doi.org/10.5599/admet.1023	https://doi.org/10.5599/admet.1023	PROPN
admet-1209	85	13	.	.	PUNCT
admet-1209	86	1	[	[	X
admet-1209	86	2	15	15	NUM
admet-1209	86	3	]	]	X
admet-1209	86	4	d	d	X
admet-1209	86	5	-	-	PUNCT
admet-1209	86	6	h.	h.	PROPN
admet-1209	86	7	won	won	NOUN
admet-1209	86	8	,	,	PUNCT
admet-1209	86	9	l	l	PROPN
admet-1209	86	10	-	-	PROPN
admet-1209	86	11	h.	h.	PROPN
admet-1209	86	12	kim	kim	PROPN
admet-1209	86	13	,	,	PUNCT
admet-1209	86	14	b.	b.	PROPN
admet-1209	86	15	jang	jang	PROPN
admet-1209	86	16	,	,	PUNCT
admet-1209	86	17	i	i	PROPN
admet-1209	86	18	-	-	PUNCT
admet-1209	86	19	h.	h.	PROPN
admet-1209	86	20	yang	yang	PROPN
admet-1209	86	21	,	,	PUNCT
admet-1209	86	22	h	h	PROPN
admet-1209	86	23	-	-	PUNCT
admet-1209	86	24	j.	j.	PROPN
admet-1209	86	25	kwon	kwon	PROPN
admet-1209	86	26	,	,	PUNCT
admet-1209	86	27	b.	b.	PROPN
admet-1209	86	28	jin	jin	PROPN
admet-1209	86	29	,	,	PUNCT
admet-1209	86	30	s.	s.	PROPN
admet-1209	86	31	h.	h.	PROPN
admet-1209	87	1	oh	oh	INTJ
admet-1209	87	2	,	,	PUNCT
admet-1209	87	3	j	j	PROPN
admet-1209	87	4	-	-	PROPN
admet-1209	87	5	h.	h.	PROPN
admet-1209	87	6	kang	kang	PROPN
admet-1209	87	7	,	,	PUNCT
admet-1209	87	8	s	s	PROPN
admet-1209	87	9	-	-	PROPN
admet-1209	87	10	d.	d.	PROPN
admet-1209	87	11	hong	hong	PROPN
admet-1209	87	12	,	,	PUNCT
admet-1209	87	13	j	j	PROPN
admet-1209	87	14	-	-	PUNCT
admet-1209	87	15	a.	a.	NOUN
admet-1209	87	16	shin	shin	PROPN
admet-1209	87	17	,	,	PUNCT
admet-1209	87	18	s	s	PROPN
admet-1209	87	19	-	-	PROPN
admet-1209	87	20	d.	d.	PROPN
admet-1209	87	21	cho	cho	PROPN
admet-1209	87	22	.	.	PUNCT
admet-1209	88	1	in	in	ADP
admet-1209	88	2	vitro	vitro	X
admet-1209	88	3	and	and	CCONJ
admet-1209	88	4	in	in	ADP
admet-1209	88	5	vivo	vivo	ADJ
admet-1209	88	6	anti	anti	ADJ
admet-1209	88	7	-	-	ADJ
admet-1209	88	8	cancer	cancer	ADJ
admet-1209	88	9	activity	activity	NOUN
admet-1209	88	10	of	of	ADP
admet-1209	88	11	silymarin	silymarin	NOUN
admet-1209	88	12	on	on	ADP
admet-1209	88	13	oral	oral	ADJ
admet-1209	88	14	cancer	cancer	NOUN
admet-1209	88	15	.	.	PUNCT
admet-1209	89	1	tumor	tumor	NOUN
admet-1209	89	2	biology	biology	NOUN
admet-1209	89	3	40	40	NUM
admet-1209	89	4	(	(	PUNCT
admet-1209	89	5	2018	2018	NUM
admet-1209	89	6	)	)	PUNCT
admet-1209	89	7	111	111	NUM
admet-1209	89	8	.	.	PUNCT
admet-1209	90	1	https://doi.org/10.1177/1010428318776170	https://doi.org/10.1177/1010428318776170	X
admet-1209	90	2	.	.	PUNCT
admet-1209	91	1	http://dx.doi.org/10.5599/admet.1209	http://dx.doi.org/10.5599/admet.1209	VERB
admet-1209	91	2	https://doi.org/10.1086/ipe.7.25056188	https://doi.org/10.1086/ipe.7.25056188	PROPN
admet-1209	91	3	https://doi.org/10.1186/s12967-016-0838-4	https://doi.org/10.1186/s12967-016-0838-4	NUM
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admet-1209	91	9	http://terramedica.hsinetwork.com/hult%20-%20incremental%20innovation%20and%20pharmaceutical%20productivity.pdf	http://terramedica.hsinetwork.com/hult%20-%20incremental%20innovation%20and%20pharmaceutical%20productivity.pdf	PROPN
admet-1209	91	10	https://www.fda.gov/drugs/drug-approvals-and-databases/compilation-cder-new-molecular-entity-nme-drug-and-new-biologic-approvals	https://www.fda.gov/drugs/drug-approvals-and-databases/compilation-cder-new-molecular-entity-nme-drug-and-new-biologic-approval	NOUN
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admet-1209	93	5	(	(	PUNCT
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admet-1209	93	7	)	)	PUNCT
admet-1209	93	8	231	231	NUM
admet-1209	93	9	-	-	SYM
admet-1209	93	10	242	242	NUM
admet-1209	93	11	.	.	PUNCT
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admet-1209	95	9	.	.	PUNCT
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admet-1209	95	14	we	we	PRON
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admet-1209	96	5	(	(	PUNCT
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admet-1209	96	7	)	)	PUNCT
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admet-1209	96	9	-	-	SYM
admet-1209	96	10	281	281	NUM
admet-1209	96	11	.	.	PUNCT
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admet-1209	97	2	.	.	PUNCT
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admet-1209	98	2	2021	2021	NUM
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admet-1209	98	13	.	.	PUNCT
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admet-1209	99	2	article	article	NOUN
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admet-1209	99	4	an	an	DET
admet-1209	99	5	open	open	ADJ
admet-1209	99	6	-	-	PUNCT
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admet-1209	99	8	article	article	NOUN
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admet-1209	99	10	under	under	ADP
admet-1209	99	11	the	the	DET
admet-1209	99	12	terms	term	NOUN
admet-1209	99	13	and	and	CCONJ
admet-1209	99	14	conditions	condition	NOUN
admet-1209	99	15	of	of	ADP
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admet-1209	99	17	creative	creative	ADJ
admet-1209	99	18	commons	common	NOUN
admet-1209	99	19	attribution	attribution	NOUN
admet-1209	99	20	license	license	NOUN
admet-1209	99	21	(	(	PUNCT
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admet-1209	99	23	)	)	PUNCT
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admet-1209	99	25	https://doi.org/10.5599/admet.951	https://doi.org/10.5599/admet.951	NOUN
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admet-1209	99	27	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN