id	sid	tid	token	lemma	pos
admet-1272	1	1	old	old	ADJ
admet-1272	1	2	and	and	CCONJ
admet-1272	1	3	modern	modern	ADJ
admet-1272	1	4	antibiotic	antibiotic	ADJ
admet-1272	1	5	structures	structure	NOUN
admet-1272	1	6	with	with	ADP
admet-1272	1	7	potential	potential	NOUN
admet-1272	1	8	for	for	ADP
admet-1272	1	9	today	today	NOUN
admet-1272	1	10	’s	’s	PART
admet-1272	1	11	infections	infection	NOUN
admet-1272	1	12	doi	doi	NOUN
admet-1272	1	13	:	:	PUNCT
admet-1272	1	14	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	PROPN
admet-1272	1	15	131	131	NUM
admet-1272	1	16	admet	admet	X
admet-1272	1	17	&	&	CCONJ
admet-1272	1	18	dmpk	dmpk	PROPN
admet-1272	1	19	10(2	10(2	NUM
admet-1272	1	20	)	)	PUNCT
admet-1272	1	21	(	(	PUNCT
admet-1272	1	22	2022	2022	NUM
admet-1272	1	23	)	)	PUNCT
admet-1272	1	24	131	131	NUM
admet-1272	1	25	-	-	SYM
admet-1272	1	26	146	146	NUM
admet-1272	1	27	;	;	PUNCT
admet-1272	1	28	doi	doi	NOUN
admet-1272	1	29	:	:	PUNCT
admet-1272	1	30	https://doi.org/10.5599/admet.1272	https://doi.org/10.5599/admet.1272	ADJ
admet-1272	1	31	open	open	ADJ
admet-1272	1	32	access	access	NOUN
admet-1272	1	33	:	:	PUNCT
admet-1272	1	34	issn	issn	PROPN
admet-1272	1	35	:	:	PUNCT
admet-1272	1	36	1848	1848	NUM
admet-1272	1	37	-	-	SYM
admet-1272	1	38	7718	7718	NUM
admet-1272	1	39	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1272	1	40	review	review	NOUN
admet-1272	1	41	old	old	ADJ
admet-1272	1	42	and	and	CCONJ
admet-1272	1	43	modern	modern	ADJ
admet-1272	1	44	antibiotic	antibiotic	ADJ
admet-1272	1	45	structures	structure	NOUN
admet-1272	1	46	with	with	ADP
admet-1272	1	47	potential	potential	NOUN
admet-1272	1	48	for	for	ADP
admet-1272	1	49	today	today	NOUN
admet-1272	1	50	’s	’s	PART
admet-1272	1	51	infections	infection	NOUN
admet-1272	1	52	david	david	PROPN
admet-1272	1	53	j.	j.	PROPN
admet-1272	1	54	newman	newman	PROPN
admet-1272	1	55	nih	nih	PROPN
admet-1272	1	56	special	special	PROPN
admet-1272	1	57	volunteer	volunteer	PROPN
admet-1272	1	58	,	,	PUNCT
admet-1272	1	59	wayne	wayne	PROPN
admet-1272	1	60	,	,	PUNCT
admet-1272	1	61	pa	pa	PROPN
admet-1272	1	62	19087	19087	NUM
admet-1272	1	63	us	we	PRON
admet-1272	1	64	.	.	PUNCT
admet-1272	2	1	email	email	NOUN
admet-1272	2	2	:	:	PUNCT
admet-1272	2	3	djnewman664@verizon.net	djnewman664@verizon.net	PROPN
admet-1272	2	4	.	.	PROPN
admet-1272	2	5	received	receive	VERB
admet-1272	2	6	:	:	PUNCT
admet-1272	2	7	january	january	PROPN
admet-1272	2	8	31	31	NUM
admet-1272	2	9	,	,	PUNCT
admet-1272	2	10	2022	2022	NUM
admet-1272	2	11	;	;	PUNCT
admet-1272	2	12	revised	revise	VERB
admet-1272	2	13	:	:	PUNCT
admet-1272	2	14	february	february	PROPN
admet-1272	2	15	13	13	NUM
admet-1272	2	16	,	,	PUNCT
admet-1272	2	17	2022	2022	NUM
admet-1272	2	18	;	;	PUNCT
admet-1272	2	19	available	available	ADJ
admet-1272	2	20	march	march	PROPN
admet-1272	2	21	04	04	NUM
admet-1272	2	22	,	,	PUNCT
admet-1272	2	23	2022	2022	NUM
admet-1272	2	24	abstract	abstract	NOUN
admet-1272	2	25	due	due	ADP
admet-1272	2	26	to	to	ADP
admet-1272	2	27	the	the	DET
admet-1272	2	28	lack	lack	NOUN
admet-1272	2	29	of	of	ADP
admet-1272	2	30	new	new	ADJ
admet-1272	2	31	antibiotics	antibiotic	NOUN
admet-1272	2	32	with	with	ADP
admet-1272	2	33	efficacy	efficacy	NOUN
admet-1272	2	34	against	against	ADP
admet-1272	2	35	the	the	DET
admet-1272	2	36	eskape	eskape	NOUN
admet-1272	2	37	and	and	CCONJ
admet-1272	2	38	other	other	ADJ
admet-1272	2	39	resistant	resistant	ADJ
admet-1272	2	40	microbes	microbe	NOUN
admet-1272	2	41	,	,	PUNCT
admet-1272	2	42	coupled	couple	VERB
admet-1272	2	43	to	to	ADP
admet-1272	2	44	the	the	DET
admet-1272	2	45	demise	demise	NOUN
admet-1272	2	46	of	of	ADP
admet-1272	2	47	major	major	ADJ
admet-1272	2	48	pharmaceutical	pharmaceutical	ADJ
admet-1272	2	49	company	company	NOUN
admet-1272	2	50	antibiotic	antibiotic	ADJ
admet-1272	2	51	discovery	discovery	NOUN
admet-1272	2	52	programs	program	NOUN
admet-1272	2	53	,	,	PUNCT
admet-1272	2	54	due	due	ADP
admet-1272	2	55	to	to	ADP
admet-1272	2	56	a	a	DET
admet-1272	2	57	number	number	NOUN
admet-1272	2	58	of	of	ADP
admet-1272	2	59	factors	factor	NOUN
admet-1272	2	60	but	but	CCONJ
admet-1272	2	61	mainly	mainly	ADV
admet-1272	2	62	roi	roi	NOUN
admet-1272	2	63	calculations	calculation	NOUN
admet-1272	2	64	and	and	CCONJ
admet-1272	2	65	the	the	DET
admet-1272	2	66	lack	lack	NOUN
admet-1272	2	67	of	of	ADP
admet-1272	2	68	efficacy	efficacy	NOUN
admet-1272	2	69	of	of	ADP
admet-1272	2	70	combinatorial	combinatorial	ADJ
admet-1272	2	71	chemistry	chemistry	NOUN
admet-1272	2	72	as	as	ADP
admet-1272	2	73	a	a	DET
admet-1272	2	74	substitute	substitute	NOUN
admet-1272	2	75	,	,	PUNCT
admet-1272	2	76	the	the	DET
admet-1272	2	77	search	search	NOUN
admet-1272	2	78	for	for	ADP
admet-1272	2	79	novel	novel	ADJ
admet-1272	2	80	antibiotics	antibiotic	NOUN
admet-1272	2	81	may	may	AUX
admet-1272	2	82	well	well	ADV
admet-1272	2	83	have	have	AUX
admet-1272	2	84	moved	move	VERB
admet-1272	2	85	to	to	ADP
admet-1272	2	86	the	the	DET
admet-1272	2	87	utilization	utilization	NOUN
admet-1272	2	88	of	of	ADP
admet-1272	2	89	older	old	ADJ
admet-1272	2	90	structures	structure	NOUN
admet-1272	2	91	with	with	ADP
admet-1272	2	92	significant	significant	ADJ
admet-1272	2	93	synthetic	synthetic	ADJ
admet-1272	2	94	chemistry	chemistry	NOUN
admet-1272	2	95	input	input	NOUN
admet-1272	2	96	.	.	PUNCT
admet-1272	3	1	this	this	DET
admet-1272	3	2	short	short	ADJ
admet-1272	3	3	review	review	NOUN
admet-1272	3	4	demonstrates	demonstrate	VERB
admet-1272	3	5	how	how	SCONJ
admet-1272	3	6	modern	modern	ADJ
admet-1272	3	7	synthetic	synthetic	ADJ
admet-1272	3	8	chemistry	chemistry	NOUN
admet-1272	3	9	,	,	PUNCT
admet-1272	3	10	when	when	SCONJ
admet-1272	3	11	applied	apply	VERB
admet-1272	3	12	to	to	ADP
admet-1272	3	13	either	either	DET
admet-1272	3	14	modification	modification	NOUN
admet-1272	3	15	of	of	ADP
admet-1272	3	16	current	current	ADJ
admet-1272	3	17	resistant	resistant	ADJ
admet-1272	3	18	antibiotics	antibiotic	NOUN
admet-1272	3	19	such	such	ADJ
admet-1272	3	20	as	as	ADP
admet-1272	3	21	glycopeptides	glycopeptide	NOUN
admet-1272	3	22	,	,	PUNCT
admet-1272	3	23	or	or	CCONJ
admet-1272	3	24	production	production	NOUN
admet-1272	3	25	of	of	ADP
admet-1272	3	26	novel	novel	ADJ
admet-1272	3	27	peptidic	peptidic	ADJ
admet-1272	3	28	agents	agent	NOUN
admet-1272	3	29	based	base	VERB
admet-1272	3	30	on	on	ADP
admet-1272	3	31	natural	natural	ADJ
admet-1272	3	32	product	product	NOUN
admet-1272	3	33	sourced	source	VERB
admet-1272	3	34	antimicrobial	antimicrobial	ADJ
admet-1272	3	35	peptides	peptide	NOUN
admet-1272	3	36	(	(	PUNCT
admet-1272	3	37	amps	amp	NOUN
admet-1272	3	38	)	)	PUNCT
admet-1272	3	39	and	and	CCONJ
admet-1272	3	40	other	other	ADJ
admet-1272	3	41	potential	potential	ADJ
admet-1272	3	42	initial	initial	ADJ
admet-1272	3	43	peptide	peptide	NOUN
admet-1272	3	44	-	-	PUNCT
admet-1272	3	45	based	base	VERB
admet-1272	3	46	agents	agent	NOUN
admet-1272	3	47	from	from	ADP
admet-1272	3	48	genomic	genomic	ADJ
admet-1272	3	49	searches	search	NOUN
admet-1272	3	50	and	and	CCONJ
admet-1272	3	51	baiting	bait	VERB
admet-1272	3	52	techniques	technique	NOUN
admet-1272	3	53	,	,	PUNCT
admet-1272	3	54	have	have	AUX
admet-1272	3	55	produced	produce	VERB
admet-1272	3	56	active	active	ADJ
admet-1272	3	57	agents	agent	NOUN
admet-1272	3	58	of	of	ADP
admet-1272	3	59	significant	significant	ADJ
admet-1272	3	60	utility	utility	NOUN
admet-1272	3	61	.	.	PUNCT
admet-1272	4	1	in	in	ADP
admet-1272	4	2	addition	addition	NOUN
admet-1272	4	3	,	,	PUNCT
admet-1272	4	4	synthetic	synthetic	ADJ
admet-1272	4	5	chemistry	chemistry	NOUN
admet-1272	4	6	practitioners	practitioner	NOUN
admet-1272	4	7	have	have	AUX
admet-1272	4	8	now	now	ADV
admet-1272	4	9	shown	show	VERB
admet-1272	4	10	that	that	SCONJ
admet-1272	4	11	they	they	PRON
admet-1272	4	12	can	can	AUX
admet-1272	4	13	produce	produce	VERB
admet-1272	4	14	bioactive	bioactive	ADJ
admet-1272	4	15	molecules	molecule	NOUN
admet-1272	4	16	of	of	ADP
admet-1272	4	17	greater	great	ADJ
admet-1272	4	18	than	than	ADP
admet-1272	4	19	800	800	NUM
admet-1272	4	20	daltons	dalton	NOUN
admet-1272	4	21	in	in	ADP
admet-1272	4	22	kilogram	kilogram	PROPN
admet-1272	4	23	quantities	quantity	NOUN
admet-1272	4	24	under	under	ADP
admet-1272	4	25	cgmp	cgmp	PROPN
admet-1272	4	26	conditions	condition	NOUN
admet-1272	4	27	.	.	PUNCT
admet-1272	5	1	©	©	X
admet-1272	5	2	2022	2022	NUM
admet-1272	5	3	by	by	ADP
admet-1272	5	4	the	the	DET
admet-1272	5	5	author	author	NOUN
admet-1272	5	6	.	.	PUNCT
admet-1272	6	1	this	this	DET
admet-1272	6	2	article	article	NOUN
admet-1272	6	3	is	be	AUX
admet-1272	6	4	an	an	DET
admet-1272	6	5	open	open	ADJ
admet-1272	6	6	-	-	PUNCT
admet-1272	6	7	access	access	NOUN
admet-1272	6	8	article	article	NOUN
admet-1272	6	9	distributed	distribute	VERB
admet-1272	6	10	under	under	ADP
admet-1272	6	11	the	the	DET
admet-1272	6	12	terms	term	NOUN
admet-1272	6	13	and	and	CCONJ
admet-1272	6	14	conditions	condition	NOUN
admet-1272	6	15	of	of	ADP
admet-1272	6	16	the	the	DET
admet-1272	6	17	creative	creative	ADJ
admet-1272	6	18	commons	common	NOUN
admet-1272	6	19	attribution	attribution	NOUN
admet-1272	6	20	license	license	NOUN
admet-1272	6	21	(	(	PUNCT
admet-1272	6	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1272	6	23	)	)	PUNCT
admet-1272	6	24	.	.	PUNCT
admet-1272	7	1	keywords	keyword	VERB
admet-1272	7	2	peptides	peptide	NOUN
admet-1272	7	3	;	;	PUNCT
admet-1272	7	4	synthesis	synthesis	NOUN
admet-1272	7	5	;	;	PUNCT
admet-1272	7	6	pathogens	pathogen	NOUN
admet-1272	7	7	introduction	introduction	NOUN
admet-1272	7	8	with	with	ADP
admet-1272	7	9	the	the	DET
admet-1272	7	10	advent	advent	NOUN
admet-1272	7	11	of	of	ADP
admet-1272	7	12	what	what	PRON
admet-1272	7	13	might	might	AUX
admet-1272	7	14	be	be	AUX
admet-1272	7	15	called	call	VERB
admet-1272	7	16	the	the	DET
admet-1272	7	17	“	"	PUNCT
admet-1272	7	18	dangerous	dangerous	ADJ
admet-1272	7	19	sextet	sextet	NOUN
admet-1272	7	20	”	"	PUNCT
admet-1272	7	21	of	of	ADP
admet-1272	7	22	current	current	ADJ
admet-1272	7	23	bacterial	bacterial	ADJ
admet-1272	7	24	infections	infection	NOUN
admet-1272	7	25	viz	viz	NUM
admet-1272	7	26	enterococcus	enterococcus	NOUN
admet-1272	7	27	faecium	faecium	NOUN
admet-1272	7	28	,	,	PUNCT
admet-1272	7	29	staphylococcus	staphylococcus	NOUN
admet-1272	7	30	aureus	aureus	NOUN
admet-1272	7	31	,	,	PUNCT
admet-1272	7	32	klebsiella	klebsiella	PROPN
admet-1272	7	33	pneumoniae	pneumoniae	NOUN
admet-1272	7	34	,	,	PUNCT
admet-1272	7	35	acinetobacter	acinetobacter	ADV
admet-1272	7	36	baumannii	baumannii	PROPN
admet-1272	7	37	,	,	PUNCT
admet-1272	7	38	pseudomonas	pseudomona	NOUN
admet-1272	7	39	aeruginosa	aeruginosa	NOUN
admet-1272	7	40	,	,	PUNCT
admet-1272	7	41	and	and	CCONJ
admet-1272	7	42	enterobacter	enterobacter	ADJ
admet-1272	7	43	spp	spp	NOUN
admet-1272	7	44	.	.	PUNCT
admet-1272	8	1	(	(	PUNCT
admet-1272	8	2	aka	aka	ADV
admet-1272	8	3	the	the	DET
admet-1272	8	4	eskape	eskape	NOUN
admet-1272	8	5	pathogens	pathogen	NOUN
admet-1272	8	6	)	)	PUNCT
admet-1272	8	7	,	,	PUNCT
admet-1272	8	8	came	come	VERB
admet-1272	8	9	to	to	ADP
admet-1272	8	10	the	the	DET
admet-1272	8	11	frequently	frequently	ADV
admet-1272	8	12	belated	belate	VERB
admet-1272	8	13	realization	realization	NOUN
admet-1272	8	14	that	that	SCONJ
admet-1272	8	15	the	the	DET
admet-1272	8	16	antibiotics	antibiotic	NOUN
admet-1272	8	17	in	in	ADP
admet-1272	8	18	current	current	ADJ
admet-1272	8	19	use	use	NOUN
admet-1272	8	20	were	be	AUX
admet-1272	8	21	not	not	PART
admet-1272	8	22	effective	effective	ADJ
admet-1272	8	23	as	as	ADP
admet-1272	8	24	single	single	ADJ
admet-1272	8	25	agents	agent	NOUN
admet-1272	8	26	against	against	ADP
admet-1272	8	27	most	most	ADJ
admet-1272	8	28	,	,	PUNCT
admet-1272	8	29	if	if	SCONJ
admet-1272	8	30	not	not	PART
admet-1272	8	31	all	all	PRON
admet-1272	8	32	,	,	PUNCT
admet-1272	8	33	of	of	ADP
admet-1272	8	34	these	these	DET
admet-1272	8	35	organisms	organism	NOUN
admet-1272	8	36	.	.	PUNCT
admet-1272	9	1	in	in	ADP
admet-1272	9	2	a	a	DET
admet-1272	9	3	few	few	ADJ
admet-1272	9	4	advanced	advanced	ADJ
admet-1272	9	5	countries	country	NOUN
admet-1272	9	6	,	,	PUNCT
admet-1272	9	7	expensive	expensive	ADJ
admet-1272	9	8	antibiotic	antibiotic	ADJ
admet-1272	9	9	drugs	drug	NOUN
admet-1272	9	10	with	with	ADP
admet-1272	9	11	suitable	suitable	ADJ
admet-1272	9	12	activities	activity	NOUN
admet-1272	9	13	might	might	AUX
admet-1272	9	14	be	be	AUX
admet-1272	9	15	available	available	ADJ
admet-1272	9	16	,	,	PUNCT
admet-1272	9	17	but	but	CCONJ
admet-1272	9	18	these	these	DET
admet-1272	9	19	infections	infection	NOUN
admet-1272	9	20	ignore	ignore	VERB
admet-1272	9	21	economic	economic	ADJ
admet-1272	9	22	boundaries	boundary	NOUN
admet-1272	9	23	.	.	PUNCT
admet-1272	10	1	thus	thus	ADV
admet-1272	10	2	,	,	PUNCT
admet-1272	10	3	it	it	PRON
admet-1272	10	4	behooves	behoove	VERB
admet-1272	10	5	researchers	researcher	NOUN
admet-1272	10	6	to	to	PART
admet-1272	10	7	reinvestigate	reinvestigate	VERB
admet-1272	10	8	and/or	and/or	CCONJ
admet-1272	10	9	modify	modify	VERB
admet-1272	10	10	agents	agent	NOUN
admet-1272	10	11	that	that	PRON
admet-1272	10	12	,	,	PUNCT
admet-1272	10	13	in	in	ADP
admet-1272	10	14	earlier	early	ADJ
admet-1272	10	15	days	day	NOUN
admet-1272	10	16	,	,	PUNCT
admet-1272	10	17	were	be	AUX
admet-1272	10	18	ignored	ignore	VERB
admet-1272	10	19	due	due	ADP
admet-1272	10	20	to	to	ADP
admet-1272	10	21	their	their	PRON
admet-1272	10	22	toxicities	toxicity	NOUN
admet-1272	10	23	,	,	PUNCT
admet-1272	10	24	difficulty	difficulty	NOUN
admet-1272	10	25	in	in	ADP
admet-1272	10	26	dosing	dose	VERB
admet-1272	10	27	,	,	PUNCT
admet-1272	10	28	chemical	chemical	NOUN
admet-1272	10	29	stability	stability	NOUN
admet-1272	10	30	or	or	CCONJ
admet-1272	10	31	side	side	NOUN
admet-1272	10	32	effects	effect	NOUN
admet-1272	10	33	due	due	ADJ
admet-1272	10	34	to	to	ADP
admet-1272	10	35	their	their	PRON
admet-1272	10	36	unknown	unknown	ADJ
admet-1272	10	37	interactions	interaction	NOUN
admet-1272	10	38	.	.	PUNCT
admet-1272	11	1	the	the	DET
admet-1272	11	2	world	world	PROPN
admet-1272	11	3	health	health	PROPN
admet-1272	11	4	organization	organization	NOUN
admet-1272	11	5	included	include	VERB
admet-1272	11	6	the	the	DET
admet-1272	11	7	organisms	organism	NOUN
admet-1272	11	8	above	above	ADV
admet-1272	11	9	in	in	ADP
admet-1272	11	10	their	their	PRON
admet-1272	11	11	listing	listing	NOUN
admet-1272	11	12	of	of	ADP
admet-1272	11	13	dangerous	dangerous	ADJ
admet-1272	11	14	microbes	microbe	NOUN
admet-1272	11	15	,	,	PUNCT
admet-1272	11	16	as	as	SCONJ
admet-1272	11	17	shown	show	VERB
admet-1272	11	18	below	below	ADP
admet-1272	11	19	.	.	PUNCT
admet-1272	12	1	on	on	ADP
admet-1272	12	2	the	the	DET
admet-1272	12	3	17th	17th	NOUN
admet-1272	12	4	of	of	ADP
admet-1272	12	5	february	february	PROPN
admet-1272	12	6	2017	2017	NUM
admet-1272	12	7	,	,	PUNCT
admet-1272	12	8	they	they	PRON
admet-1272	12	9	published	publish	VERB
admet-1272	12	10	a	a	DET
admet-1272	12	11	list	list	NOUN
admet-1272	12	12	of	of	ADP
admet-1272	12	13	twelve	twelve	NUM
admet-1272	12	14	microbes	microbe	NOUN
admet-1272	12	15	that	that	PRON
admet-1272	12	16	were	be	AUX
admet-1272	12	17	of	of	ADP
admet-1272	12	18	concern	concern	NOUN
admet-1272	12	19	as	as	SCONJ
admet-1272	12	20	they	they	PRON
admet-1272	12	21	were	be	AUX
admet-1272	12	22	all	all	ADV
admet-1272	12	23	resistant	resistant	ADJ
admet-1272	12	24	to	to	ADP
admet-1272	12	25	a	a	DET
admet-1272	12	26	significant	significant	ADJ
admet-1272	12	27	number	number	NOUN
admet-1272	12	28	of	of	ADP
admet-1272	12	29	antibiotics	antibiotic	NOUN
admet-1272	12	30	then	then	ADV
admet-1272	12	31	in	in	ADP
admet-1272	12	32	current	current	ADJ
admet-1272	12	33	use	use	NOUN
admet-1272	12	34	.	.	PUNCT
admet-1272	13	1	this	this	DET
admet-1272	13	2	list	list	NOUN
admet-1272	13	3	was	be	AUX
admet-1272	13	4	meant	mean	VERB
admet-1272	13	5	to	to	PART
admet-1272	13	6	be	be	AUX
admet-1272	13	7	a	a	DET
admet-1272	13	8	“	"	PUNCT
admet-1272	13	9	wake	wake	VERB
admet-1272	13	10	-	-	PUNCT
admet-1272	13	11	up	up	ADP
admet-1272	13	12	call	call	NOUN
admet-1272	13	13	”	"	PUNCT
admet-1272	13	14	to	to	ADP
admet-1272	13	15	the	the	DET
admet-1272	13	16	pharmaceutical	pharmaceutical	ADJ
admet-1272	13	17	industry	industry	NOUN
admet-1272	13	18	/	/	SYM
admet-1272	14	1	scientists	scientist	NOUN
admet-1272	14	2	involved	involve	VERB
admet-1272	14	3	in	in	ADP
admet-1272	14	4	the	the	DET
admet-1272	14	5	discovery	discovery	NOUN
admet-1272	14	6	of	of	ADP
admet-1272	14	7	new	new	ADJ
admet-1272	14	8	antibiotics	antibiotic	NOUN
admet-1272	14	9	,	,	PUNCT
admet-1272	14	10	be	be	AUX
admet-1272	14	11	they	they	PRON
admet-1272	14	12	natural	natural	ADJ
admet-1272	14	13	products	product	NOUN
admet-1272	14	14	,	,	PUNCT
admet-1272	14	15	semisynthetic	semisynthetic	ADJ
admet-1272	14	16	or	or	CCONJ
admet-1272	14	17	totally	totally	ADV
admet-1272	14	18	synthetic	synthetic	ADJ
admet-1272	14	19	entities	entity	NOUN
admet-1272	14	20	,	,	PUNCT
admet-1272	14	21	by	by	ADP
admet-1272	14	22	showing	show	VERB
admet-1272	14	23	how	how	SCONJ
admet-1272	14	24	widespread	widespread	ADJ
admet-1272	14	25	resistance	resistance	NOUN
admet-1272	14	26	is	be	AUX
admet-1272	14	27	.	.	PUNCT
admet-1272	15	1	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	PROPN
admet-1272	16	1	https://doi.org/10.5599/admet.1272	https://doi.org/10.5599/admet.1272	PROPN
admet-1272	16	2	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-1272	16	3	mailto:djnewman664@verizon.net	mailto:djnewman664@verizon.net	PROPN
admet-1272	16	4	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1272	16	5	david	david	PROPN
admet-1272	16	6	j.	j.	PROPN
admet-1272	16	7	newman	newman	PROPN
admet-1272	16	8	admet	admet	PROPN
admet-1272	16	9	&	&	CCONJ
admet-1272	16	10	dmpk	dmpk	PROPN
admet-1272	16	11	10(2	10(2	NUM
admet-1272	16	12	)	)	PUNCT
admet-1272	16	13	(	(	PUNCT
admet-1272	16	14	2022	2022	NUM
admet-1272	16	15	)	)	PUNCT
admet-1272	16	16	131	131	NUM
admet-1272	16	17	-	-	SYM
admet-1272	16	18	146	146	NUM
admet-1272	16	19	132	132	NUM
admet-1272	16	20	on	on	ADP
admet-1272	16	21	the	the	DET
admet-1272	16	22	list	list	NOUN
admet-1272	16	23	(	(	PUNCT
admet-1272	16	24	www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/	www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/	PROPN
admet-1272	16	25	)	)	PUNCT
admet-1272	16	26	,	,	PUNCT
admet-1272	16	27			PUNCT
admet-1272	16	28	the	the	DET
admet-1272	16	29	first	first	ADJ
admet-1272	16	30	three	three	NUM
admet-1272	16	31	(	(	PUNCT
admet-1272	16	32	priority	priority	NOUN
admet-1272	16	33	1	1	NUM
admet-1272	16	34	listed	list	VERB
admet-1272	16	35	as	as	ADP
admet-1272	16	36	critical	critical	ADJ
admet-1272	16	37	)	)	PUNCT
admet-1272	16	38	were	be	AUX
admet-1272	16	39	the	the	DET
admet-1272	16	40	gram	gram	NOUN
admet-1272	16	41	-	-	PUNCT
admet-1272	16	42	negative	negative	ADJ
admet-1272	16	43	organisms	organism	NOUN
admet-1272	16	44	acinetobacter	acinetobacter	ADV
admet-1272	16	45	baumannii	baumannii	ADJ
admet-1272	16	46	(	(	PUNCT
admet-1272	16	47	carbapenem	carbapenem	NOUN
admet-1272	16	48	-	-	PUNCT
admet-1272	16	49	resistant	resistant	ADJ
admet-1272	16	50	)	)	PUNCT
admet-1272	16	51	;	;	PUNCT
admet-1272	16	52	pseudomonas	pseudomona	NOUN
admet-1272	16	53	aeruginosa	aeruginosa	NOUN
admet-1272	16	54	(	(	PUNCT
admet-1272	16	55	carbapenem	carbapenem	NOUN
admet-1272	16	56	-	-	PUNCT
admet-1272	16	57	resistant	resistant	ADJ
admet-1272	16	58	)	)	PUNCT
admet-1272	16	59	;	;	PUNCT
admet-1272	16	60	enterobacteriaceae	enterobacteriaceae	PROPN
admet-1272	16	61	(	(	PUNCT
admet-1272	16	62	carbapenem	carbapenem	NOUN
admet-1272	16	63	-	-	PUNCT
admet-1272	16	64	resistant	resistant	ADJ
admet-1272	16	65	,	,	PUNCT
admet-1272	16	66	esbl	esbl	NOUN
admet-1272	16	67	-	-	PUNCT
admet-1272	16	68	producing	produce	VERB
admet-1272	16	69	)	)	PUNCT
admet-1272	16	70	.	.	PUNCT
admet-1272	17	1			PUNCT
admet-1272	18	1	the	the	DET
admet-1272	18	2	next	next	ADJ
admet-1272	18	3	6	6	NUM
admet-1272	18	4	(	(	PUNCT
admet-1272	18	5	priority	priority	NOUN
admet-1272	18	6	2	2	NUM
admet-1272	18	7	listed	list	VERB
admet-1272	18	8	as	as	ADP
admet-1272	18	9	high	high	ADJ
admet-1272	18	10	)	)	PUNCT
admet-1272	18	11	contained	contain	VERB
admet-1272	18	12	two	two	NUM
admet-1272	18	13	very	very	ADV
admet-1272	18	14	well	well	ADV
admet-1272	18	15	-	-	PUNCT
admet-1272	18	16	known	know	VERB
admet-1272	18	17	gram	gram	NOUN
admet-1272	18	18	-	-	PUNCT
admet-1272	18	19	positive	positive	ADJ
admet-1272	18	20	pathogens	pathogen	NOUN
admet-1272	18	21	,	,	PUNCT
admet-1272	18	22	enterococcus	enterococcus	NOUN
admet-1272	18	23	faecium	faecium	NOUN
admet-1272	18	24	(	(	PUNCT
admet-1272	18	25	resistant	resistant	ADJ
admet-1272	18	26	to	to	ADP
admet-1272	18	27	vancomycin	vancomycin	PROPN
admet-1272	18	28	)	)	PUNCT
admet-1272	18	29	and	and	CCONJ
admet-1272	18	30	staphylococcus	staphylococcus	NOUN
admet-1272	18	31	aureus	aureus	NOUN
admet-1272	18	32	(	(	PUNCT
admet-1272	18	33	mrsa	mrsa	NOUN
admet-1272	18	34	)	)	PUNCT
admet-1272	18	35	,	,	PUNCT
admet-1272	18	36	and	and	CCONJ
admet-1272	18	37	four	four	NUM
admet-1272	18	38	gramnegative	gramnegative	ADJ
admet-1272	18	39	pathogens	pathogen	NOUN
admet-1272	18	40	.	.	PUNCT
admet-1272	19	1	helicobacter	helicobacter	NOUN
admet-1272	19	2	pylori	pylori	NOUN
admet-1272	19	3	(	(	PUNCT
admet-1272	19	4	clarithromycin	clarithromycin	NOUN
admet-1272	19	5	-	-	PUNCT
admet-1272	19	6	resistant	resistant	ADJ
admet-1272	19	7	)	)	PUNCT
admet-1272	19	8	;	;	PUNCT
admet-1272	19	9	campylobacter	campylobacter	NOUN
admet-1272	19	10	spp	spp	NOUN
admet-1272	19	11	.	.	PUNCT
admet-1272	20	1	(	(	PUNCT
admet-1272	20	2	fluoroquinolone	fluoroquinolone	NOUN
admet-1272	20	3	-	-	PUNCT
admet-1272	20	4	resistant	resistant	ADJ
admet-1272	20	5	)	)	PUNCT
admet-1272	20	6	;	;	PUNCT
admet-1272	20	7	salmonellae	salmonellae	NOUN
admet-1272	20	8	(	(	PUNCT
admet-1272	20	9	fluoroquinolone	fluoroquinolone	NOUN
admet-1272	20	10	-	-	PUNCT
admet-1272	20	11	resistant	resistant	ADJ
admet-1272	20	12	)	)	PUNCT
admet-1272	20	13	and	and	CCONJ
admet-1272	20	14	neisseria	neisseria	PROPN
admet-1272	20	15	gonorrhoeae	gonorrhoeae	PROPN
admet-1272	20	16	(	(	PUNCT
admet-1272	20	17	cephalosporin	cephalosporin	NOUN
admet-1272	20	18	-	-	PUNCT
admet-1272	20	19	resistant	resistant	ADJ
admet-1272	20	20	,	,	PUNCT
admet-1272	20	21	fluoroquinolone	fluoroquinolone	NOUN
admet-1272	20	22	-	-	PUNCT
admet-1272	20	23	resistant	resistant	ADJ
admet-1272	20	24	)	)	PUNCT
admet-1272	20	25	.	.	PUNCT
admet-1272	21	1			PUNCT
admet-1272	21	2	the	the	DET
admet-1272	21	3	last	last	ADJ
admet-1272	21	4	three	three	NUM
admet-1272	21	5	(	(	PUNCT
admet-1272	21	6	priority	priority	NOUN
admet-1272	21	7	3	3	NUM
admet-1272	21	8	listed	list	VERB
admet-1272	21	9	as	as	ADP
admet-1272	21	10	medium	medium	NOUN
admet-1272	21	11	)	)	PUNCT
admet-1272	21	12	were	be	AUX
admet-1272	21	13	the	the	DET
admet-1272	21	14	gram	gram	NOUN
admet-1272	21	15	-	-	PUNCT
admet-1272	21	16	positive	positive	ADJ
admet-1272	21	17	streptococcus	streptococcus	NOUN
admet-1272	21	18	pneumoniae	pneumoniae	ADJ
admet-1272	21	19	(	(	PUNCT
admet-1272	21	20	penicillin	penicillin	NOUN
admet-1272	21	21	-	-	PUNCT
admet-1272	21	22	non	non	ADJ
admet-1272	21	23	-	-	ADJ
admet-1272	21	24	susceptible	susceptible	ADJ
admet-1272	21	25	)	)	PUNCT
admet-1272	21	26	and	and	CCONJ
admet-1272	21	27	the	the	DET
admet-1272	21	28	two	two	NUM
admet-1272	21	29	gram	gram	NOUN
admet-1272	21	30	-	-	PUNCT
admet-1272	21	31	negative	negative	ADJ
admet-1272	21	32	haemophilus	haemophilus	NOUN
admet-1272	21	33	influenzae	influenzae	X
admet-1272	21	34	ampicillinresistant	ampicillinresistant	NOUN
admet-1272	21	35	)	)	PUNCT
admet-1272	21	36	and	and	CCONJ
admet-1272	21	37	shigella	shigella	PROPN
admet-1272	21	38	spp	spp	PROPN
admet-1272	21	39	.	.	PUNCT
admet-1272	22	1	(	(	PUNCT
admet-1272	22	2	fluoroquinolone	fluoroquinolone	NOUN
admet-1272	22	3	-	-	PUNCT
admet-1272	22	4	resistant	resistant	ADJ
admet-1272	22	5	)	)	PUNCT
admet-1272	22	6	.	.	PUNCT
admet-1272	23	1	what	what	PRON
admet-1272	23	2	will	will	AUX
admet-1272	23	3	be	be	AUX
admet-1272	23	4	described	describe	VERB
admet-1272	23	5	in	in	ADP
admet-1272	23	6	this	this	DET
admet-1272	23	7	article	article	NOUN
admet-1272	23	8	are	be	AUX
admet-1272	23	9	examples	example	NOUN
admet-1272	23	10	culled	cull	VERB
admet-1272	23	11	from	from	ADP
admet-1272	23	12	the	the	DET
admet-1272	23	13	recent	recent	ADJ
admet-1272	23	14	literature	literature	NOUN
admet-1272	23	15	where	where	SCONJ
admet-1272	23	16	elegant	elegant	ADJ
admet-1272	23	17	chemistry	chemistry	NOUN
admet-1272	23	18	and	and	CCONJ
admet-1272	23	19	modernized	modernize	VERB
admet-1272	23	20	microbiological	microbiological	ADJ
admet-1272	23	21	techniques	technique	NOUN
admet-1272	23	22	have	have	AUX
admet-1272	23	23	led	lead	VERB
admet-1272	23	24	to	to	ADP
admet-1272	23	25	modifications	modification	NOUN
admet-1272	23	26	of	of	ADP
admet-1272	23	27	old	old	ADJ
admet-1272	23	28	agents	agent	NOUN
admet-1272	23	29	and/or	and/or	CCONJ
admet-1272	23	30	the	the	DET
admet-1272	23	31	administration	administration	NOUN
admet-1272	23	32	of	of	ADP
admet-1272	23	33	“	"	PUNCT
admet-1272	23	34	adjuncts	adjunct	NOUN
admet-1272	23	35	”	"	PUNCT
admet-1272	23	36	that	that	PRON
admet-1272	23	37	has	have	AUX
admet-1272	23	38	enabled	enable	VERB
admet-1272	23	39	the	the	DET
admet-1272	23	40	renewed	renew	VERB
admet-1272	23	41	usage	usage	NOUN
admet-1272	23	42	of	of	ADP
admet-1272	23	43	agents	agent	NOUN
admet-1272	23	44	that	that	SCONJ
admet-1272	23	45	in	in	ADP
admet-1272	23	46	the	the	DET
admet-1272	23	47	“	"	PUNCT
admet-1272	23	48	halcyon	halcyon	ADJ
admet-1272	23	49	days	day	NOUN
admet-1272	23	50	of	of	ADP
admet-1272	23	51	yore	yore	NOUN
admet-1272	23	52	”	"	PUNCT
admet-1272	23	53	,	,	PUNCT
admet-1272	23	54	which	which	PRON
admet-1272	23	55	covered	cover	VERB
admet-1272	23	56	from	from	ADP
admet-1272	23	57	the	the	DET
admet-1272	23	58	early	early	ADJ
admet-1272	23	59	1960s	1960	NOUN
admet-1272	23	60	until	until	ADP
admet-1272	23	61	the	the	DET
admet-1272	23	62	effective	effective	ADJ
admet-1272	23	63	elimination	elimination	NOUN
admet-1272	23	64	of	of	ADP
admet-1272	23	65	large	large	ADJ
admet-1272	23	66	-	-	PUNCT
admet-1272	23	67	scale	scale	NOUN
admet-1272	23	68	antibiotic	antibiotic	ADJ
admet-1272	23	69	discovery	discovery	NOUN
admet-1272	23	70	programs	program	NOUN
admet-1272	23	71	in	in	ADP
admet-1272	23	72	“	"	PUNCT
admet-1272	23	73	big	big	ADJ
admet-1272	23	74	pharma	pharma	NOUN
admet-1272	23	75	”	"	PUNCT
admet-1272	23	76	,	,	PUNCT
admet-1272	23	77	which	which	PRON
admet-1272	23	78	with	with	ADP
admet-1272	23	79	a	a	DET
admet-1272	23	80	few	few	ADJ
admet-1272	23	81	exceptions	exception	NOUN
admet-1272	23	82	would	would	AUX
admet-1272	23	83	be	be	AUX
admet-1272	23	84	pre-1990	pre-1990	NOUN
admet-1272	23	85	.	.	PUNCT
admet-1272	24	1	the	the	DET
admet-1272	24	2	demise	demise	NOUN
admet-1272	24	3	of	of	ADP
admet-1272	24	4	combinatorial	combinatorial	ADJ
admet-1272	24	5	chemistry	chemistry	NOUN
admet-1272	24	6	as	as	ADP
admet-1272	24	7	a	a	DET
admet-1272	24	8	source	source	NOUN
admet-1272	24	9	of	of	ADP
admet-1272	24	10	antiinfective	antiinfective	ADJ
admet-1272	24	11	lead	lead	NOUN
admet-1272	24	12	structures	structure	NOUN
admet-1272	24	13	it	it	PRON
admet-1272	24	14	would	would	AUX
admet-1272	24	15	be	be	AUX
admet-1272	24	16	worth	worth	ADJ
admet-1272	24	17	commenting	comment	VERB
admet-1272	24	18	here	here	ADV
admet-1272	24	19	that	that	SCONJ
admet-1272	24	20	possibly	possibly	ADV
admet-1272	24	21	the	the	DET
admet-1272	24	22	major	major	ADJ
admet-1272	24	23	“	"	PUNCT
admet-1272	24	24	player	player	NOUN
admet-1272	24	25	”	"	PUNCT
admet-1272	24	26	in	in	ADP
admet-1272	24	27	the	the	DET
admet-1272	24	28	elimination	elimination	NOUN
admet-1272	24	29	of	of	ADP
admet-1272	24	30	searching	search	VERB
admet-1272	24	31	for	for	ADP
admet-1272	24	32	microbial	microbial	ADJ
admet-1272	24	33	-	-	PUNCT
admet-1272	24	34	sourced	source	VERB
admet-1272	24	35	agents	agent	NOUN
admet-1272	24	36	by	by	ADP
admet-1272	24	37	“	"	PUNCT
admet-1272	24	38	big	big	ADJ
admet-1272	24	39	pharma	pharma	NOUN
admet-1272	24	40	”	"	PUNCT
admet-1272	24	41	was	be	AUX
admet-1272	24	42	the	the	DET
admet-1272	24	43	concept	concept	NOUN
admet-1272	24	44	of	of	ADP
admet-1272	24	45	large	large	ADJ
admet-1272	24	46	-	-	PUNCT
admet-1272	24	47	scale	scale	NOUN
admet-1272	24	48	to	to	ADP
admet-1272	24	49	very	very	ADV
admet-1272	24	50	large	large	ADJ
admet-1272	24	51	scale	scale	NOUN
admet-1272	24	52	(	(	PUNCT
admet-1272	24	53	>	>	NOUN
admet-1272	24	54	106	106	NUM
admet-1272	24	55	)	)	PUNCT
admet-1272	24	56	syntheses	synthesis	NOUN
admet-1272	24	57	of	of	ADP
admet-1272	24	58	small	small	ADJ
admet-1272	24	59	compounds	compound	NOUN
admet-1272	24	60	via	via	ADP
admet-1272	24	61	combinatorial	combinatorial	ADJ
admet-1272	24	62	chemistry	chemistry	NOUN
admet-1272	24	63	.	.	PUNCT
admet-1272	25	1	the	the	DET
admet-1272	25	2	idea	idea	NOUN
admet-1272	25	3	was	be	AUX
admet-1272	25	4	that	that	SCONJ
admet-1272	25	5	these	these	DET
admet-1272	25	6	agents	agent	NOUN
admet-1272	25	7	would	would	AUX
admet-1272	25	8	be	be	AUX
admet-1272	25	9	patentable	patentable	ADJ
admet-1272	25	10	and	and	CCONJ
admet-1272	25	11	“	"	PUNCT
admet-1272	25	12	easily	easily	ADV
admet-1272	25	13	synthesized	synthesize	VERB
admet-1272	25	14	”	"	PUNCT
admet-1272	25	15	,	,	PUNCT
admet-1272	25	16	rather	rather	ADV
admet-1272	25	17	than	than	ADP
admet-1272	25	18	have	have	VERB
admet-1272	25	19	the	the	DET
admet-1272	25	20	large	large	ADJ
admet-1272	25	21	-	-	PUNCT
admet-1272	25	22	scale	scale	NOUN
admet-1272	25	23	systems	system	NOUN
admet-1272	25	24	necessary	necessary	ADJ
admet-1272	25	25	for	for	ADP
admet-1272	25	26	natural	natural	ADJ
admet-1272	25	27	product	product	NOUN
admet-1272	25	28	sourced	source	VERB
admet-1272	25	29	agents	agent	NOUN
admet-1272	25	30	.	.	PUNCT
admet-1272	26	1	in	in	ADP
admet-1272	26	2	addition	addition	NOUN
admet-1272	26	3	,	,	PUNCT
admet-1272	26	4	a	a	DET
admet-1272	26	5	major	major	ADJ
admet-1272	26	6	problem	problem	NOUN
admet-1272	26	7	with	with	ADP
admet-1272	26	8	microbial	microbial	ADJ
admet-1272	26	9	sourcing	sourcing	NOUN
admet-1272	26	10	(	(	PUNCT
admet-1272	26	11	the	the	DET
admet-1272	26	12	major	major	ADJ
admet-1272	26	13	source	source	NOUN
admet-1272	26	14	used	use	VERB
admet-1272	26	15	in	in	ADP
admet-1272	26	16	all	all	DET
admet-1272	26	17	earlier	early	ADJ
admet-1272	26	18	cases	case	NOUN
admet-1272	26	19	)	)	PUNCT
admet-1272	26	20	was	be	AUX
admet-1272	26	21	the	the	DET
admet-1272	26	22	task(s	task(s	NOUN
admet-1272	26	23	)	)	PUNCT
admet-1272	26	24	associated	associate	VERB
admet-1272	26	25	with	with	ADP
admet-1272	26	26	what	what	PRON
admet-1272	26	27	became	became	AUX
admet-1272	26	28	known	know	VERB
admet-1272	26	29	as	as	ADP
admet-1272	26	30	“	"	PUNCT
admet-1272	26	31	dereplication	dereplication	NOUN
admet-1272	26	32	”	"	PUNCT
admet-1272	26	33	,	,	PUNCT
admet-1272	26	34	or	or	CCONJ
admet-1272	26	35	the	the	DET
admet-1272	26	36	ability	ability	NOUN
admet-1272	26	37	to	to	PART
admet-1272	26	38	rapidly	rapidly	ADV
admet-1272	26	39	decide	decide	VERB
admet-1272	26	40	whether	whether	SCONJ
admet-1272	26	41	an	an	DET
admet-1272	26	42	isolated	isolated	ADJ
admet-1272	26	43	compound	compound	NOUN
admet-1272	26	44	was	be	AUX
admet-1272	26	45	new	new	ADJ
admet-1272	26	46	or	or	CCONJ
admet-1272	26	47	old	old	ADJ
admet-1272	26	48	and	and	CCONJ
admet-1272	26	49	often	often	ADV
admet-1272	26	50	known	know	VERB
admet-1272	26	51	under	under	ADP
admet-1272	26	52	a	a	DET
admet-1272	26	53	variety	variety	NOUN
admet-1272	26	54	of	of	ADP
admet-1272	26	55	names	name	NOUN
admet-1272	26	56	.	.	PUNCT
admet-1272	27	1	it	it	PRON
admet-1272	27	2	should	should	AUX
admet-1272	27	3	be	be	AUX
admet-1272	27	4	noted	note	VERB
admet-1272	27	5	that	that	SCONJ
admet-1272	27	6	the	the	DET
admet-1272	27	7	advent	advent	NOUN
admet-1272	27	8	of	of	ADP
admet-1272	27	9	>	>	SYM
admet-1272	27	10	100	100	NUM
admet-1272	27	11	mhz	mhz	ADJ
admet-1272	27	12	nmr	nmr	NOUN
admet-1272	27	13	,	,	PUNCT
admet-1272	27	14	portable	portable	ADJ
admet-1272	27	15	computers	computer	NOUN
admet-1272	27	16	,	,	PUNCT
admet-1272	27	17	accessible	accessible	ADJ
admet-1272	27	18	compound	compound	NOUN
admet-1272	27	19	databases	database	NOUN
admet-1272	27	20	and	and	CCONJ
admet-1272	27	21	automated	automate	VERB
admet-1272	27	22	hplcs	hplcs	NOUN
admet-1272	27	23	were	be	AUX
admet-1272	27	24	way	way	NOUN
admet-1272	27	25	in	in	ADP
admet-1272	27	26	the	the	DET
admet-1272	27	27	future	future	NOUN
admet-1272	27	28	,	,	PUNCT
admet-1272	27	29	even	even	ADV
admet-1272	27	30	in	in	ADP
admet-1272	27	31	the	the	DET
admet-1272	27	32	early	early	ADJ
admet-1272	27	33	1980s	1980s	NUM
admet-1272	27	34	.	.	PUNCT
admet-1272	28	1	the	the	DET
admet-1272	28	2	irony	irony	NOUN
admet-1272	28	3	in	in	ADP
admet-1272	28	4	the	the	DET
admet-1272	28	5	early	early	ADJ
admet-1272	28	6	days	day	NOUN
admet-1272	28	7	of	of	ADP
admet-1272	28	8	combichem	combichem	NOUN
admet-1272	28	9	was	be	AUX
admet-1272	28	10	that	that	SCONJ
admet-1272	28	11	the	the	DET
admet-1272	28	12	original	original	ADJ
admet-1272	28	13	“	"	PUNCT
admet-1272	28	14	successes	success	NOUN
admet-1272	28	15	quoted	quote	VERB
admet-1272	28	16	for	for	ADP
admet-1272	28	17	increased	increase	VERB
admet-1272	28	18	bioactivity	bioactivity	NOUN
admet-1272	28	19	”	"	PUNCT
admet-1272	28	20	used	use	VERB
admet-1272	28	21	peptide	peptide	NOUN
admet-1272	28	22	-	-	PUNCT
admet-1272	28	23	based	base	VERB
admet-1272	28	24	molecules	molecule	NOUN
admet-1272	28	25	or	or	CCONJ
admet-1272	28	26	small	small	ADJ
admet-1272	28	27	compounds	compound	NOUN
admet-1272	28	28	based	base	VERB
admet-1272	28	29	on	on	ADP
admet-1272	28	30	bioactive	bioactive	ADJ
admet-1272	28	31	natural	natural	ADJ
admet-1272	28	32	products	product	NOUN
admet-1272	28	33	as	as	ADP
admet-1272	28	34	their	their	PRON
admet-1272	28	35	starting	starting	NOUN
admet-1272	28	36	points	point	NOUN
admet-1272	28	37	.	.	PUNCT
admet-1272	29	1	an	an	DET
admet-1272	29	2	excellent	excellent	ADJ
admet-1272	29	3	example	example	NOUN
admet-1272	29	4	of	of	ADP
admet-1272	29	5	what	what	PRON
admet-1272	29	6	happened	happen	VERB
admet-1272	29	7	when	when	SCONJ
admet-1272	29	8	combichem	combichem	NOUN
admet-1272	29	9	structures	structure	NOUN
admet-1272	29	10	were	be	AUX
admet-1272	29	11	substituted	substitute	VERB
admet-1272	29	12	for	for	ADP
admet-1272	29	13	products	product	NOUN
admet-1272	29	14	from	from	ADP
admet-1272	29	15	natural	natural	ADJ
admet-1272	29	16	sources	source	NOUN
admet-1272	29	17	and/or	and/or	CCONJ
admet-1272	29	18	their	their	PRON
admet-1272	29	19	derivatives	derivative	NOUN
admet-1272	29	20	was	be	AUX
admet-1272	29	21	the	the	DET
admet-1272	29	22	review	review	NOUN
admet-1272	29	23	in	in	ADP
admet-1272	29	24	2007	2007	NUM
admet-1272	29	25	,	,	PUNCT
admet-1272	29	26	giving	give	VERB
admet-1272	29	27	the	the	DET
admet-1272	29	28	total	total	ADJ
admet-1272	29	29	lack	lack	NOUN
admet-1272	29	30	of	of	ADP
admet-1272	29	31	success	success	NOUN
admet-1272	29	32	when	when	SCONJ
admet-1272	29	33	massive	massive	ADJ
admet-1272	29	34	numbers	number	NOUN
admet-1272	29	35	of	of	ADP
admet-1272	29	36	combichem	combichem	NOUN
admet-1272	29	37	structures	structure	NOUN
admet-1272	29	38	met	meet	VERB
admet-1272	29	39	up	up	ADP
admet-1272	29	40	with	with	ADP
admet-1272	29	41	~70	~70	ADJ
admet-1272	29	42	isolated	isolate	VERB
admet-1272	29	43	targets	target	NOUN
admet-1272	29	44	at	at	ADP
admet-1272	29	45	gsk	gsk	NOUN
admet-1272	29	46	[	[	X
admet-1272	29	47	1	1	NUM
admet-1272	29	48	]	]	PUNCT
admet-1272	29	49	.	.	PUNCT
admet-1272	30	1	i	i	PRON
admet-1272	30	2	should	should	AUX
admet-1272	30	3	point	point	VERB
admet-1272	30	4	out	out	ADP
admet-1272	30	5	at	at	ADP
admet-1272	30	6	this	this	DET
admet-1272	30	7	stage	stage	NOUN
admet-1272	30	8	that	that	PRON
admet-1272	30	9	i	i	PRON
admet-1272	30	10	was	be	AUX
admet-1272	30	11	part	part	NOUN
admet-1272	30	12	of	of	ADP
admet-1272	30	13	the	the	DET
admet-1272	30	14	earlier	early	ADJ
admet-1272	30	15	sk&f	sk&f	PROPN
admet-1272	30	16	antibiotics	antibiotic	NOUN
admet-1272	30	17	program	program	NOUN
admet-1272	30	18	based	base	VERB
admet-1272	30	19	on	on	ADP
admet-1272	30	20	microbial	microbial	ADJ
admet-1272	30	21	sources	source	NOUN
admet-1272	30	22	and	and	CCONJ
admet-1272	30	23	modification	modification	NOUN
admet-1272	30	24	of	of	ADP
admet-1272	30	25	beta	beta	NOUN
admet-1272	30	26	-	-	PUNCT
admet-1272	30	27	lactam	lactam	NOUN
admet-1272	30	28	based	base	VERB
admet-1272	30	29	molecules	molecule	NOUN
admet-1272	30	30	from	from	ADP
admet-1272	30	31	1976	1976	NUM
admet-1272	30	32	to	to	ADP
admet-1272	30	33	its	its	PRON
admet-1272	30	34	sudden	sudden	ADJ
admet-1272	30	35	demise	demise	NOUN
admet-1272	30	36	in	in	ADP
admet-1272	30	37	april	april	PROPN
admet-1272	30	38	of	of	ADP
admet-1272	30	39	1985	1985	NUM
admet-1272	30	40	.	.	PUNCT
admet-1272	31	1	that	that	DET
admet-1272	31	2	program	program	NOUN
admet-1272	31	3	was	be	AUX
admet-1272	31	4	certainly	certainly	ADV
admet-1272	31	5	more	more	ADV
admet-1272	31	6	successful	successful	ADJ
admet-1272	31	7	than	than	ADP
admet-1272	31	8	its	its	PRON
admet-1272	31	9	subsequent	subsequent	ADJ
admet-1272	31	10	descendants	descendant	NOUN
admet-1272	31	11	.	.	PUNCT
admet-1272	32	1	a	a	DET
admet-1272	32	2	2015	2015	NUM
admet-1272	32	3	paper	paper	NOUN
admet-1272	32	4	by	by	ADP
admet-1272	32	5	blaskovich	blaskovich	PROPN
admet-1272	32	6	et	et	PROPN
admet-1272	32	7	al	al	PROPN
admet-1272	32	8	.	.	PROPN
admet-1272	32	9	gives	give	VERB
admet-1272	32	10	more	more	ADJ
admet-1272	32	11	of	of	ADP
admet-1272	32	12	the	the	DET
admet-1272	32	13	subsequent	subsequent	ADJ
admet-1272	32	14	history	history	NOUN
admet-1272	32	15	of	of	ADP
admet-1272	32	16	the	the	DET
admet-1272	32	17	demise	demise	NOUN
admet-1272	32	18	of	of	ADP
admet-1272	32	19	promising	promise	VERB
admet-1272	32	20	antibiotic	antibiotic	ADJ
admet-1272	32	21	programs	program	NOUN
admet-1272	32	22	by	by	ADP
admet-1272	32	23	large	large	ADJ
admet-1272	32	24	pharma	pharma	NOUN
admet-1272	32	25	in	in	ADP
admet-1272	32	26	the	the	DET
admet-1272	32	27	subsequent	subsequent	ADJ
admet-1272	32	28	years	year	NOUN
admet-1272	32	29	to	to	ADP
admet-1272	32	30	2015	2015	NUM
admet-1272	32	31	[	[	X
admet-1272	32	32	2	2	NUM
admet-1272	32	33	]	]	PUNCT
admet-1272	32	34	.	.	PUNCT
admet-1272	33	1	in	in	ADP
admet-1272	33	2	the	the	DET
admet-1272	33	3	following	follow	VERB
admet-1272	33	4	sections	section	NOUN
admet-1272	33	5	,	,	PUNCT
admet-1272	33	6	i	i	PRON
admet-1272	33	7	will	will	AUX
admet-1272	33	8	illustrate	illustrate	VERB
admet-1272	33	9	how	how	SCONJ
admet-1272	33	10	,	,	PUNCT
admet-1272	33	11	by	by	ADP
admet-1272	33	12	building	build	VERB
admet-1272	33	13	upon	upon	SCONJ
admet-1272	33	14	“	"	PUNCT
admet-1272	33	15	old	old	ADJ
admet-1272	33	16	or	or	CCONJ
admet-1272	33	17	at	at	ADP
admet-1272	33	18	times	time	NOUN
admet-1272	33	19	new	new	ADJ
admet-1272	33	20	structures	structure	NOUN
admet-1272	33	21	”	"	PUNCT
admet-1272	33	22	by	by	ADP
admet-1272	33	23	competent	competent	ADJ
admet-1272	33	24	scientists	scientist	NOUN
admet-1272	33	25	(	(	PUNCT
admet-1272	33	26	chemists	chemist	NOUN
admet-1272	33	27	and	and	CCONJ
admet-1272	33	28	microbiologists	microbiologist	NOUN
admet-1272	33	29	)	)	PUNCT
admet-1272	33	30	,	,	PUNCT
admet-1272	33	31	and/or	and/or	CCONJ
admet-1272	33	32	by	by	ADP
admet-1272	33	33	utilizing	utilize	VERB
admet-1272	33	34	modern	modern	ADJ
admet-1272	33	35	techniques	technique	NOUN
admet-1272	33	36	based	base	VERB
admet-1272	33	37	on	on	ADP
admet-1272	33	38	earlier	early	ADJ
admet-1272	33	39	systems	system	NOUN
admet-1272	33	40	,	,	PUNCT
admet-1272	33	41	old	old	ADJ
admet-1272	33	42	structures	structure	NOUN
admet-1272	33	43	suddenly	suddenly	ADV
admet-1272	33	44	became	become	VERB
admet-1272	33	45	significant	significant	ADJ
admet-1272	33	46	candidates	candidate	NOUN
admet-1272	33	47	for	for	ADP
admet-1272	33	48	clinical	clinical	ADJ
admet-1272	33	49	trials	trial	NOUN
admet-1272	33	50	,	,	PUNCT
admet-1272	33	51	and	and	CCONJ
admet-1272	33	52	nowadays	nowadays	ADV
admet-1272	33	53	utilization	utilization	NOUN
admet-1272	33	54	of	of	ADP
admet-1272	33	55	the	the	DET
admet-1272	33	56	enormous	enormous	ADJ
admet-1272	33	57	capabilities	capability	NOUN
admet-1272	33	58	of	of	ADP
admet-1272	33	59	genetic	genetic	ADJ
admet-1272	33	60	manipulation	manipulation	NOUN
admet-1272	33	61	can	can	AUX
admet-1272	33	62	lead	lead	VERB
admet-1272	33	63	to	to	ADP
admet-1272	33	64	novel	novel	ADJ
admet-1272	33	65	agents	agent	NOUN
admet-1272	33	66	with	with	ADP
admet-1272	33	67	the	the	DET
admet-1272	33	68	desired	desire	VERB
admet-1272	33	69	attributes	attribute	NOUN
admet-1272	33	70	against	against	ADP
admet-1272	33	71	the	the	DET
admet-1272	33	72	eskape	eskape	NOUN
admet-1272	33	73	pathogens	pathogen	NOUN
admet-1272	33	74	and	and	CCONJ
admet-1272	33	75	their	their	PRON
admet-1272	33	76	subsequent	subsequent	ADJ
admet-1272	33	77	descendants	descendant	NOUN
admet-1272	33	78	.	.	PUNCT
admet-1272	34	1	http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/	http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/	ADJ
admet-1272	34	2	admet	admet	PROPN
admet-1272	34	3	&	&	CCONJ
admet-1272	34	4	dmpk	dmpk	PROPN
admet-1272	34	5	10(2	10(2	NUM
admet-1272	34	6	)	)	PUNCT
admet-1272	34	7	(	(	PUNCT
admet-1272	34	8	2022	2022	NUM
admet-1272	34	9	)	)	PUNCT
admet-1272	34	10	131	131	NUM
admet-1272	34	11	-	-	SYM
admet-1272	34	12	146	146	NUM
admet-1272	34	13	chemical	chemical	NOUN
admet-1272	34	14	syntheses	synthesis	NOUN
admet-1272	34	15	and	and	CCONJ
admet-1272	34	16	resistant	resistant	ADJ
admet-1272	34	17	antibiotics	antibiotic	NOUN
admet-1272	34	18	doi	doi	NOUN
admet-1272	34	19	:	:	PUNCT
admet-1272	34	20	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	X
admet-1272	34	21	133	133	NUM
admet-1272	34	22	vancomycin	vancomycin	PROPN
admet-1272	34	23	and	and	CCONJ
admet-1272	34	24	other	other	ADJ
admet-1272	34	25	glycopeptides	glycopeptide	NOUN
admet-1272	34	26	;	;	PUNCT
admet-1272	34	27	initial	initial	ADJ
admet-1272	34	28	and	and	CCONJ
admet-1272	34	29	later	later	ADJ
admet-1272	34	30	history	history	NOUN
admet-1272	34	31	for	for	ADP
admet-1272	34	32	a	a	DET
admet-1272	34	33	significant	significant	ADJ
admet-1272	34	34	number	number	NOUN
admet-1272	34	35	of	of	ADP
admet-1272	34	36	years	year	NOUN
admet-1272	34	37	,	,	PUNCT
admet-1272	34	38	vancomycin	vancomycin	PROPN
admet-1272	34	39	(	(	PUNCT
admet-1272	34	40	1	1	NUM
admet-1272	34	41	)	)	PUNCT
admet-1272	34	42	and	and	CCONJ
admet-1272	34	43	then	then	ADV
admet-1272	34	44	later	later	ADV
admet-1272	34	45	its	its	PRON
admet-1272	34	46	close	close	ADJ
admet-1272	34	47	chemical	chemical	ADJ
admet-1272	34	48	relatives	relative	NOUN
admet-1272	34	49	were	be	AUX
admet-1272	34	50	often	often	ADV
admet-1272	34	51	defined	define	VERB
admet-1272	34	52	as	as	ADP
admet-1272	34	53	the	the	DET
admet-1272	34	54	“	"	PUNCT
admet-1272	34	55	antibiotic	antibiotic	NOUN
admet-1272	34	56	of	of	ADP
admet-1272	34	57	last	last	ADJ
admet-1272	34	58	resort	resort	NOUN
admet-1272	34	59	”	"	PUNCT
admet-1272	34	60	.	.	PUNCT
admet-1272	35	1	vancomycin	vancomycin	PROPN
admet-1272	35	2	was	be	AUX
admet-1272	35	3	originally	originally	ADV
admet-1272	35	4	introduced	introduce	VERB
admet-1272	35	5	into	into	ADP
admet-1272	35	6	clinical	clinical	ADJ
admet-1272	35	7	medicine	medicine	NOUN
admet-1272	35	8	by	by	ADP
admet-1272	35	9	lilly	lilly	PROPN
admet-1272	35	10	in	in	ADP
admet-1272	35	11	the	the	DET
admet-1272	35	12	middle	middle	NOUN
admet-1272	35	13	to	to	ADP
admet-1272	35	14	late	late	ADJ
admet-1272	35	15	1950s	1950	NOUN
admet-1272	35	16	,	,	PUNCT
admet-1272	35	17	though	though	SCONJ
admet-1272	35	18	there	there	PRON
admet-1272	35	19	is	be	VERB
admet-1272	35	20	a	a	DET
admet-1272	35	21	debate	debate	NOUN
admet-1272	35	22	in	in	ADP
admet-1272	35	23	the	the	DET
admet-1272	35	24	literature	literature	NOUN
admet-1272	35	25	as	as	ADP
admet-1272	35	26	to	to	ADP
admet-1272	35	27	the	the	DET
admet-1272	35	28	actual	actual	ADJ
admet-1272	35	29	date	date	NOUN
admet-1272	35	30	.	.	PUNCT
admet-1272	36	1	the	the	DET
admet-1272	36	2	integrityr	integrityr	NOUN
admet-1272	36	3	database	database	NOUN
admet-1272	36	4	(	(	PUNCT
admet-1272	36	5	now	now	ADV
admet-1272	36	6	clarivate	clarivate	ADJ
admet-1272	36	7	analytics	analytic	NOUN
admet-1272	36	8	)	)	PUNCT
admet-1272	36	9	uses	use	VERB
admet-1272	36	10	1955	1955	NUM
admet-1272	36	11	,	,	PUNCT
admet-1272	36	12	but	but	CCONJ
admet-1272	36	13	butler	butler	PROPN
admet-1272	36	14	et	et	PROPN
admet-1272	36	15	al	al	PROPN
admet-1272	36	16	.	.	PROPN
admet-1272	37	1	in	in	ADP
admet-1272	37	2	a	a	DET
admet-1272	37	3	review	review	NOUN
admet-1272	37	4	in	in	ADP
admet-1272	37	5	2014	2014	NUM
admet-1272	37	6	[	[	X
admet-1272	37	7	3	3	X
admet-1272	37	8	]	]	PUNCT
admet-1272	37	9	used	use	VERB
admet-1272	37	10	1958	1958	NUM
admet-1272	37	11	.	.	PUNCT
admet-1272	38	1	as	as	ADP
admet-1272	38	2	the	the	DET
admet-1272	38	3	fda	fda	PROPN
admet-1272	38	4	approval	approval	NOUN
admet-1272	38	5	date	date	NOUN
admet-1272	38	6	.	.	PUNCT
admet-1272	39	1	however	however	ADV
admet-1272	39	2	,	,	PUNCT
admet-1272	39	3	the	the	DET
admet-1272	39	4	actual	actual	ADJ
admet-1272	39	5	structure	structure	NOUN
admet-1272	39	6	was	be	AUX
admet-1272	39	7	not	not	PART
admet-1272	39	8	fully	fully	ADV
admet-1272	39	9	defined	define	VERB
admet-1272	39	10	until	until	ADP
admet-1272	39	11	1982	1982	NUM
admet-1272	39	12	when	when	SCONJ
admet-1272	39	13	the	the	DET
admet-1272	39	14	presence	presence	NOUN
admet-1272	39	15	of	of	ADP
admet-1272	39	16	asparagine	asparagine	NOUN
admet-1272	39	17	was	be	AUX
admet-1272	39	18	confirmed	confirm	VERB
admet-1272	39	19	[	[	X
admet-1272	40	1	4	4	NUM
admet-1272	40	2	]	]	PUNCT
admet-1272	40	3	.	.	PUNCT
admet-1272	41	1	resistance	resistance	NOUN
admet-1272	41	2	to	to	ADP
admet-1272	41	3	vancomycin	vancomycin	PROPN
admet-1272	41	4	occurred	occur	VERB
admet-1272	41	5	relatively	relatively	ADV
admet-1272	41	6	early	early	ADV
admet-1272	41	7	,	,	PUNCT
admet-1272	41	8	but	but	CCONJ
admet-1272	41	9	before	before	ADP
admet-1272	41	10	the	the	DET
admet-1272	41	11	advent	advent	NOUN
admet-1272	41	12	of	of	ADP
admet-1272	41	13	advanced	advanced	ADJ
admet-1272	41	14	structural	structural	ADJ
admet-1272	41	15	techniques	technique	NOUN
admet-1272	41	16	,	,	PUNCT
admet-1272	41	17	including	include	VERB
admet-1272	41	18	amino	amino	NOUN
admet-1272	41	19	acid	acid	NOUN
admet-1272	41	20	analyses	analysis	NOUN
admet-1272	41	21	of	of	ADP
admet-1272	41	22	gram	gram	NOUN
admet-1272	41	23	-	-	PUNCT
admet-1272	41	24	positive	positive	ADJ
admet-1272	41	25	cell	cell	NOUN
admet-1272	41	26	walls	wall	NOUN
admet-1272	41	27	,	,	PUNCT
admet-1272	41	28	the	the	DET
admet-1272	41	29	reason	reason	NOUN
admet-1272	41	30	for	for	ADP
admet-1272	41	31	the	the	DET
admet-1272	41	32	resistance	resistance	NOUN
admet-1272	41	33	was	be	AUX
admet-1272	41	34	not	not	PART
admet-1272	41	35	known	know	VERB
admet-1272	41	36	.	.	PUNCT
admet-1272	42	1	with	with	ADP
admet-1272	42	2	the	the	DET
admet-1272	42	3	advancement	advancement	NOUN
admet-1272	42	4	of	of	ADP
admet-1272	42	5	knowledge	knowledge	NOUN
admet-1272	42	6	,	,	PUNCT
admet-1272	42	7	it	it	PRON
admet-1272	42	8	became	become	VERB
admet-1272	42	9	apparent	apparent	ADJ
admet-1272	42	10	that	that	SCONJ
admet-1272	42	11	vancomycin	vancomycin	PROPN
admet-1272	42	12	(	(	PUNCT
admet-1272	42	13	and	and	CCONJ
admet-1272	42	14	its	its	AUX
admet-1272	42	15	later	later	ADV
admet-1272	42	16	naturally	naturally	ADV
admet-1272	42	17	occurring	occur	VERB
admet-1272	42	18	or	or	CCONJ
admet-1272	42	19	semisynthetic	semisynthetic	ADJ
admet-1272	42	20	“	"	PUNCT
admet-1272	42	21	chemical	chemical	ADJ
admet-1272	42	22	cousins	cousin	NOUN
admet-1272	42	23	”	"	PUNCT
admet-1272	42	24	)	)	PUNCT
admet-1272	42	25	inhibited	inhibit	VERB
admet-1272	42	26	bacterial	bacterial	ADJ
admet-1272	42	27	growth	growth	NOUN
admet-1272	42	28	by	by	ADP
admet-1272	42	29	binding	bind	VERB
admet-1272	42	30	to	to	ADP
admet-1272	42	31	the	the	DET
admet-1272	42	32	l	l	PROPN
admet-1272	42	33	-	-	PUNCT
admet-1272	42	34	lys	lys	PROPN
admet-1272	42	35	-	-	PUNCT
admet-1272	42	36	d	d	PROPN
admet-1272	42	37	-	-	PUNCT
admet-1272	42	38	ala	ala	PROPN
admet-1272	42	39	-	-	PUNCT
admet-1272	42	40	dala	dala	PROPN
admet-1272	42	41	-	-	PUNCT
admet-1272	42	42	co2h	co2h	PROPN
admet-1272	42	43	terminals	terminal	NOUN
admet-1272	42	44	in	in	ADP
admet-1272	42	45	the	the	DET
admet-1272	42	46	cross	cross	NOUN
admet-1272	42	47	-	-	NOUN
admet-1272	42	48	links	link	NOUN
admet-1272	42	49	in	in	ADP
admet-1272	42	50	the	the	DET
admet-1272	42	51	gram	gram	NOUN
admet-1272	42	52	-	-	PUNCT
admet-1272	42	53	positive	positive	ADJ
admet-1272	42	54	cell	cell	NOUN
admet-1272	42	55	wall	wall	NOUN
admet-1272	42	56	.	.	PUNCT
admet-1272	43	1	subsequent	subsequent	ADJ
admet-1272	43	2	work	work	NOUN
admet-1272	43	3	demonstrated	demonstrate	VERB
admet-1272	43	4	that	that	SCONJ
admet-1272	43	5	the	the	DET
admet-1272	43	6	vanr	vanr	ADJ
admet-1272	43	7	phenotype	phenotype	NOUN
admet-1272	43	8	was	be	AUX
admet-1272	43	9	as	as	ADP
admet-1272	43	10	a	a	DET
admet-1272	43	11	result	result	NOUN
admet-1272	43	12	of	of	ADP
admet-1272	43	13	the	the	DET
admet-1272	43	14	simple	simple	ADJ
admet-1272	43	15	change	change	NOUN
admet-1272	43	16	to	to	ADP
admet-1272	43	17	d	d	NOUN
admet-1272	43	18	-	-	PUNCT
admet-1272	43	19	lactate	lactate	NOUN
admet-1272	43	20	in	in	ADP
admet-1272	43	21	place	place	NOUN
admet-1272	43	22	of	of	ADP
admet-1272	43	23	the	the	DET
admet-1272	43	24	terminal	terminal	ADJ
admet-1272	43	25	d	d	PROPN
admet-1272	43	26	-	-	PUNCT
admet-1272	43	27	ala	ala	ADJ
admet-1272	43	28	residue	residue	NOUN
admet-1272	43	29	in	in	ADP
admet-1272	43	30	the	the	DET
admet-1272	43	31	cases	case	NOUN
admet-1272	43	32	of	of	ADP
admet-1272	43	33	vana	vana	PROPN
admet-1272	43	34	,	,	PUNCT
admet-1272	43	35	vanb	vanb	NOUN
admet-1272	43	36	,	,	PUNCT
admet-1272	43	37	vand	vand	NOUN
admet-1272	43	38	and	and	CCONJ
admet-1272	43	39	to	to	ADP
admet-1272	43	40	d	d	NOUN
admet-1272	43	41	-	-	PUNCT
admet-1272	43	42	ser	ser	NOUN
admet-1272	43	43	for	for	ADP
admet-1272	43	44	vanc	vanc	NOUN
admet-1272	43	45	,	,	PUNCT
admet-1272	43	46	vane	vane	NOUN
admet-1272	43	47	,	,	PUNCT
admet-1272	43	48	vang	vang	PROPN
admet-1272	43	49	clinical	clinical	ADJ
admet-1272	43	50	phenotypes	phenotype	NOUN
admet-1272	43	51	.	.	PUNCT
admet-1272	44	1	in	in	ADP
admet-1272	44	2	addition	addition	NOUN
admet-1272	44	3	to	to	ADP
admet-1272	44	4	vancomycin	vancomycin	PROPN
admet-1272	44	5	resistance	resistance	PROPN
admet-1272	44	6	,	,	PUNCT
admet-1272	44	7	s.	s.	PROPN
admet-1272	44	8	aureus	aureus	PROPN
admet-1272	44	9	cultures	culture	NOUN
admet-1272	44	10	that	that	PRON
admet-1272	44	11	were	be	AUX
admet-1272	44	12	classified	classify	VERB
admet-1272	44	13	as	as	ADP
admet-1272	44	14	methicillin	methicillin	NOUN
admet-1272	44	15	resistant	resistant	ADJ
admet-1272	44	16	(	(	PUNCT
admet-1272	44	17	mrsa	mrsa	NOUN
admet-1272	44	18	)	)	PUNCT
admet-1272	44	19	,	,	PUNCT
admet-1272	44	20	were	be	AUX
admet-1272	44	21	also	also	ADV
admet-1272	44	22	becoming	become	VERB
admet-1272	44	23	vancomycin	vancomycin	NOUN
admet-1272	44	24	-	-	PUNCT
admet-1272	44	25	resistant	resistant	ADJ
admet-1272	44	26	as	as	ADV
admet-1272	44	27	well	well	ADV
admet-1272	44	28	.	.	PUNCT
admet-1272	45	1	the	the	DET
admet-1272	45	2	vancomycin	vancomycin	PROPN
admet-1272	45	3	resistance	resistance	NOUN
admet-1272	45	4	level	level	NOUN
admet-1272	45	5	due	due	ADP
admet-1272	45	6	to	to	ADP
admet-1272	45	7	the	the	DET
admet-1272	45	8	d	d	PROPN
admet-1272	45	9	-	-	PUNCT
admet-1272	45	10	lac	lac	PROPN
admet-1272	45	11	substitute	substitute	NOUN
admet-1272	45	12	was	be	AUX
admet-1272	45	13	approximately	approximately	ADV
admet-1272	45	14	1000	1000	NUM
admet-1272	45	15	-	-	NUM
admet-1272	45	16	fold	fold	ADJ
admet-1272	45	17	and	and	CCONJ
admet-1272	45	18	for	for	ADP
admet-1272	45	19	the	the	DET
admet-1272	45	20	d	d	PROPN
admet-1272	45	21	-	-	NOUN
admet-1272	45	22	ser	ser	NOUN
admet-1272	45	23	modification	modification	NOUN
admet-1272	45	24	approximately	approximately	ADV
admet-1272	45	25	140	140	NUM
admet-1272	45	26	-	-	NUM
admet-1272	45	27	fold	fold	ADJ
admet-1272	45	28	.	.	PUNCT
admet-1272	46	1	interestingly	interestingly	ADV
admet-1272	46	2	,	,	PUNCT
admet-1272	46	3	the	the	DET
admet-1272	46	4	idea	idea	NOUN
admet-1272	46	5	that	that	SCONJ
admet-1272	46	6	resistance	resistance	NOUN
admet-1272	46	7	was	be	AUX
admet-1272	46	8	due	due	ADJ
admet-1272	46	9	to	to	ADP
admet-1272	46	10	the	the	DET
admet-1272	46	11	use	use	NOUN
admet-1272	46	12	of	of	ADP
admet-1272	46	13	glycopeptide	glycopeptide	NOUN
admet-1272	46	14	antibiotics	antibiotic	NOUN
admet-1272	46	15	in	in	ADP
admet-1272	46	16	animal	animal	NOUN
admet-1272	46	17	feeds	feed	VERB
admet-1272	46	18	that	that	PRON
admet-1272	46	19	then	then	ADV
admet-1272	46	20	led	lead	VERB
admet-1272	46	21	to	to	ADP
admet-1272	46	22	the	the	DET
admet-1272	46	23	resistance	resistance	NOUN
admet-1272	46	24	seen	see	VERB
admet-1272	46	25	was	be	AUX
admet-1272	46	26	shown	show	VERB
admet-1272	46	27	to	to	PART
admet-1272	46	28	be	be	AUX
admet-1272	46	29	inaccurate	inaccurate	ADJ
admet-1272	46	30	by	by	ADP
admet-1272	46	31	two	two	NUM
admet-1272	46	32	reports	report	NOUN
admet-1272	46	33	.	.	PUNCT
admet-1272	47	1	one	one	NUM
admet-1272	47	2	in	in	ADP
admet-1272	47	3	2011	2011	NUM
admet-1272	47	4	by	by	ADP
admet-1272	47	5	d’costa	d’costa	PROPN
admet-1272	47	6	et	et	NOUN
admet-1272	47	7	al	al	PROPN
admet-1272	47	8	.	.	PROPN
admet-1272	47	9	,	,	PUNCT
admet-1272	48	1	[	[	X
admet-1272	48	2	5	5	NUM
admet-1272	48	3	]	]	PUNCT
admet-1272	48	4	and	and	CCONJ
admet-1272	48	5	the	the	DET
admet-1272	48	6	other	other	ADJ
admet-1272	48	7	by	by	ADP
admet-1272	48	8	wright	wright	PROPN
admet-1272	48	9	et	et	PROPN
admet-1272	48	10	al	al	PROPN
admet-1272	48	11	.	.	PUNCT
admet-1272	49	1	[	[	X
admet-1272	49	2	6	6	NUM
admet-1272	49	3	]	]	PUNCT
admet-1272	49	4	the	the	DET
admet-1272	49	5	following	following	ADJ
admet-1272	49	6	year	year	NOUN
admet-1272	49	7	,	,	PUNCT
admet-1272	49	8	both	both	DET
admet-1272	49	9	papers	paper	NOUN
admet-1272	49	10	demonstrating	demonstrate	VERB
admet-1272	49	11	that	that	SCONJ
admet-1272	49	12	microbes	microbe	NOUN
admet-1272	49	13	over	over	ADP
admet-1272	49	14	10,000	10,000	NUM
admet-1272	49	15	years	year	NOUN
admet-1272	49	16	old	old	ADJ
admet-1272	49	17	isolated	isolate	VERB
admet-1272	49	18	from	from	ADP
admet-1272	49	19	yukon	yukon	PROPN
admet-1272	49	20	ice	ice	PROPN
admet-1272	49	21	fields	field	NOUN
admet-1272	49	22	had	have	VERB
admet-1272	49	23	similar	similar	ADJ
admet-1272	49	24	resistance	resistance	NOUN
admet-1272	49	25	phenotypes	phenotype	NOUN
admet-1272	49	26	.	.	PUNCT
admet-1272	50	1	in	in	ADP
admet-1272	50	2	the	the	DET
admet-1272	50	3	last	last	ADJ
admet-1272	50	4	few	few	ADJ
admet-1272	50	5	years	year	NOUN
admet-1272	50	6	,	,	PUNCT
admet-1272	50	7	three	three	NUM
admet-1272	50	8	semisynthetic	semisynthetic	ADJ
admet-1272	50	9	glycopeptides	glycopeptide	NOUN
admet-1272	50	10	entered	enter	VERB
admet-1272	50	11	clinical	clinical	ADJ
admet-1272	50	12	use	use	NOUN
admet-1272	50	13	in	in	ADP
admet-1272	50	14	the	the	DET
admet-1272	50	15	usa	usa	PROPN
admet-1272	50	16	and	and	CCONJ
admet-1272	50	17	other	other	ADJ
admet-1272	50	18	countries	country	NOUN
admet-1272	50	19	.	.	PUNCT
admet-1272	51	1	in	in	ADP
admet-1272	51	2	2009	2009	NUM
admet-1272	51	3	telavancin	telavancin	NOUN
admet-1272	51	4	(	(	PUNCT
admet-1272	51	5	a	a	DET
admet-1272	51	6	close	close	ADJ
admet-1272	51	7	relative	relative	NOUN
admet-1272	51	8	of	of	ADP
admet-1272	51	9	vancomycin	vancomycin	PROPN
admet-1272	51	10	)	)	PUNCT
admet-1272	51	11	was	be	AUX
admet-1272	51	12	approved	approve	VERB
admet-1272	51	13	by	by	ADP
admet-1272	51	14	the	the	DET
admet-1272	51	15	fda	fda	PROPN
admet-1272	51	16	and	and	CCONJ
admet-1272	51	17	then	then	ADV
admet-1272	51	18	in	in	ADP
admet-1272	51	19	2014	2014	NUM
admet-1272	51	20	,	,	PUNCT
admet-1272	51	21	dalbavancin	dalbavancin	PROPN
admet-1272	51	22	,	,	PUNCT
admet-1272	51	23	which	which	PRON
admet-1272	51	24	was	be	AUX
admet-1272	51	25	derived	derive	VERB
admet-1272	51	26	from	from	ADP
admet-1272	51	27	part	part	NOUN
admet-1272	51	28	of	of	ADP
admet-1272	51	29	the	the	DET
admet-1272	51	30	a40926	a40926	PROPN
admet-1272	51	31	complex	complex	NOUN
admet-1272	51	32	,	,	PUNCT
admet-1272	51	33	and	and	CCONJ
admet-1272	51	34	oritavancin	oritavancin	NOUN
admet-1272	51	35	derived	derive	VERB
admet-1272	51	36	from	from	ADP
admet-1272	51	37	chloroeremomycin	chloroeremomycin	NUM
admet-1272	51	38	were	be	AUX
admet-1272	51	39	approved	approve	VERB
admet-1272	51	40	.	.	PUNCT
admet-1272	52	1	the	the	DET
admet-1272	52	2	drug	drug	NOUN
admet-1272	52	3	complex	complex	PROPN
admet-1272	52	4	teicoplanin	teicoplanin	PROPN
admet-1272	52	5	,	,	PUNCT
admet-1272	52	6	which	which	PRON
admet-1272	52	7	is	be	AUX
admet-1272	52	8	a	a	DET
admet-1272	52	9	mixture	mixture	NOUN
admet-1272	52	10	of	of	ADP
admet-1272	52	11	closely	closely	ADV
admet-1272	52	12	related	relate	VERB
admet-1272	52	13	compounds	compound	NOUN
admet-1272	52	14	,	,	PUNCT
admet-1272	52	15	is	be	AUX
admet-1272	52	16	used	use	VERB
admet-1272	52	17	in	in	ADP
admet-1272	52	18	europe	europe	PROPN
admet-1272	52	19	and	and	CCONJ
admet-1272	52	20	interestingly	interestingly	ADV
admet-1272	52	21	,	,	PUNCT
admet-1272	52	22	there	there	PRON
admet-1272	52	23	are	be	VERB
admet-1272	52	24	some	some	DET
admet-1272	52	25	vanr	vanr	ADJ
admet-1272	52	26	phenotypes	phenotype	NOUN
admet-1272	52	27	that	that	PRON
admet-1272	52	28	are	be	AUX
admet-1272	52	29	not	not	PART
admet-1272	52	30	resistant	resistant	ADJ
admet-1272	52	31	to	to	ADP
admet-1272	52	32	this	this	DET
admet-1272	52	33	mixture	mixture	NOUN
admet-1272	52	34	and	and	CCONJ
admet-1272	52	35	the	the	DET
admet-1272	52	36	reverse	reverse	NOUN
admet-1272	52	37	also	also	ADV
admet-1272	52	38	occurs	occur	VERB
admet-1272	52	39	,	,	PUNCT
admet-1272	52	40	though	though	SCONJ
admet-1272	52	41	in	in	ADP
admet-1272	52	42	general	general	ADJ
admet-1272	52	43	,	,	PUNCT
admet-1272	52	44	most	most	ADJ
admet-1272	52	45	strains	strain	NOUN
admet-1272	52	46	are	be	AUX
admet-1272	52	47	resistant	resistant	ADJ
admet-1272	52	48	to	to	ADP
admet-1272	52	49	all	all	PRON
admet-1272	52	50	.	.	PUNCT
admet-1272	53	1	synthetic	synthetic	ADJ
admet-1272	53	2	modifications	modification	NOUN
admet-1272	53	3	of	of	ADP
admet-1272	53	4	vancomycin	vancomycin	PROPN
admet-1272	53	5	the	the	DET
admet-1272	53	6	laboratory	laboratory	NOUN
admet-1272	53	7	that	that	PRON
admet-1272	53	8	has	have	AUX
admet-1272	53	9	had	have	VERB
admet-1272	53	10	the	the	DET
admet-1272	53	11	greatest	great	ADJ
admet-1272	53	12	effect	effect	NOUN
admet-1272	53	13	on	on	ADP
admet-1272	53	14	“	"	PUNCT
admet-1272	53	15	modifying	modify	VERB
admet-1272	53	16	”	"	PUNCT
admet-1272	53	17	the	the	DET
admet-1272	53	18	basic	basic	ADJ
admet-1272	53	19	structure	structure	NOUN
admet-1272	53	20	of	of	ADP
admet-1272	53	21	vancomycin	vancomycin	PROPN
admet-1272	53	22	(	(	PUNCT
admet-1272	53	23	1	1	NUM
admet-1272	53	24	)	)	PUNCT
admet-1272	53	25	,	,	PUNCT
admet-1272	53	26	with	with	ADP
admet-1272	53	27	the	the	DET
admet-1272	53	28	aims	aim	NOUN
admet-1272	53	29	of	of	ADP
admet-1272	53	30	reducing	reduce	VERB
admet-1272	53	31	resistance	resistance	NOUN
admet-1272	53	32	and	and	CCONJ
admet-1272	53	33	potentially	potentially	ADV
admet-1272	53	34	expanding	expand	VERB
admet-1272	53	35	the	the	DET
admet-1272	53	36	range	range	NOUN
admet-1272	53	37	of	of	ADP
admet-1272	53	38	microbes	microbe	NOUN
admet-1272	53	39	that	that	PRON
admet-1272	53	40	it	it	PRON
admet-1272	53	41	can	can	AUX
admet-1272	53	42	“	"	PUNCT
admet-1272	53	43	inhibit	inhibit	VERB
admet-1272	53	44	”	"	PUNCT
admet-1272	53	45	,	,	PUNCT
admet-1272	53	46	is	be	AUX
admet-1272	53	47	,	,	PUNCT
admet-1272	53	48	without	without	ADP
admet-1272	53	49	doubt	doubt	NOUN
admet-1272	53	50	,	,	PUNCT
admet-1272	53	51	the	the	DET
admet-1272	53	52	boger	boger	PROPN
admet-1272	53	53	laboratory	laboratory	NOUN
admet-1272	53	54	at	at	ADP
admet-1272	53	55	the	the	DET
admet-1272	53	56	scripps	scripps	PROPN
admet-1272	53	57	research	research	PROPN
admet-1272	53	58	institute	institute	PROPN
admet-1272	53	59	in	in	ADP
admet-1272	53	60	la	la	PROPN
admet-1272	53	61	jolla	jolla	PROPN
admet-1272	53	62	,	,	PUNCT
admet-1272	53	63	california	california	PROPN
admet-1272	53	64	.	.	PUNCT
admet-1272	54	1	over	over	ADP
admet-1272	54	2	the	the	DET
admet-1272	54	3	last	last	ADJ
admet-1272	54	4	ten	ten	NUM
admet-1272	54	5	plus	plus	CCONJ
admet-1272	54	6	years	year	NOUN
admet-1272	54	7	,	,	PUNCT
admet-1272	54	8	that	that	DET
admet-1272	54	9	laboratory	laboratory	NOUN
admet-1272	54	10	has	have	AUX
admet-1272	54	11	published	publish	VERB
admet-1272	54	12	papers	paper	NOUN
admet-1272	54	13	showing	show	VERB
admet-1272	54	14	how	how	SCONJ
admet-1272	54	15	by	by	ADP
admet-1272	54	16	making	make	VERB
admet-1272	54	17	internal	internal	ADJ
admet-1272	54	18	modifications	modification	NOUN
admet-1272	54	19	to	to	ADP
admet-1272	54	20	the	the	DET
admet-1272	54	21	peptide	peptide	NOUN
admet-1272	54	22	backbone	backbone	NOUN
admet-1272	54	23	in	in	ADP
admet-1272	54	24	this	this	DET
admet-1272	54	25	molecule	molecule	NOUN
admet-1272	54	26	,	,	PUNCT
admet-1272	54	27	that	that	PRON
admet-1272	54	28	were	be	AUX
admet-1272	54	29	simple	simple	ADJ
admet-1272	54	30	in	in	ADP
admet-1272	54	31	concept	concept	NOUN
admet-1272	54	32	but	but	CCONJ
admet-1272	54	33	required	require	VERB
admet-1272	54	34	very	very	ADV
admet-1272	54	35	clever	clever	ADJ
admet-1272	54	36	synthetic	synthetic	ADJ
admet-1272	54	37	chemical	chemical	NOUN
admet-1272	54	38	processes	process	NOUN
admet-1272	54	39	to	to	PART
admet-1272	54	40	achieve	achieve	VERB
admet-1272	54	41	,	,	PUNCT
admet-1272	54	42	have	have	AUX
admet-1272	54	43	led	lead	VERB
admet-1272	54	44	to	to	ADP
admet-1272	54	45	a	a	DET
admet-1272	54	46	series	series	NOUN
admet-1272	54	47	of	of	ADP
admet-1272	54	48	related	relate	VERB
admet-1272	54	49	vancomycin	vancomycin	PROPN
admet-1272	54	50	molecules	molecule	NOUN
admet-1272	54	51	that	that	PRON
admet-1272	54	52	demonstrated	demonstrate	VERB
admet-1272	54	53	very	very	ADV
admet-1272	54	54	significant	significant	ADJ
admet-1272	54	55	antibiotic	antibiotic	ADJ
admet-1272	54	56	activities	activity	NOUN
admet-1272	54	57	against	against	ADP
admet-1272	54	58	mrsa	mrsa	NOUN
admet-1272	54	59	and	and	CCONJ
admet-1272	54	60	e.	e.	PROPN
admet-1272	54	61	faecalis	faecalis	PROPN
admet-1272	54	62	(	(	PUNCT
admet-1272	54	63	both	both	CCONJ
admet-1272	54	64	vana	vana	PROPN
admet-1272	54	65	&	&	CCONJ
admet-1272	54	66	vanb	vanb	ADJ
admet-1272	54	67	phenotypes	phenotype	NOUN
admet-1272	54	68	)	)	PUNCT
admet-1272	54	69	depending	depend	VERB
admet-1272	54	70	upon	upon	SCONJ
admet-1272	54	71	very	very	ADV
admet-1272	54	72	simple	simple	ADJ
admet-1272	54	73	changes	change	NOUN
admet-1272	54	74	in	in	ADP
admet-1272	54	75	one	one	NUM
admet-1272	54	76	position	position	NOUN
admet-1272	54	77	.	.	PUNCT
admet-1272	55	1	then	then	ADV
admet-1272	55	2	the	the	DET
admet-1272	55	3	boger	boger	PROPN
admet-1272	55	4	group	group	NOUN
admet-1272	55	5	extended	extend	VERB
admet-1272	55	6	the	the	DET
admet-1272	55	7	synthetic	synthetic	ADJ
admet-1272	55	8	chemistry	chemistry	NOUN
admet-1272	55	9	to	to	ADP
admet-1272	55	10	other	other	ADJ
admet-1272	55	11	parts	part	NOUN
admet-1272	55	12	of	of	ADP
admet-1272	55	13	the	the	DET
admet-1272	55	14	base	base	NOUN
admet-1272	55	15	molecule	molecule	NOUN
admet-1272	55	16	by	by	ADP
admet-1272	55	17	adding	add	VERB
admet-1272	55	18	small	small	ADJ
admet-1272	55	19	parts	part	NOUN
admet-1272	55	20	from	from	ADP
admet-1272	55	21	other	other	ADJ
admet-1272	55	22	glycopeptides	glycopeptide	NOUN
admet-1272	55	23	in	in	ADP
admet-1272	55	24	clinical	clinical	ADJ
admet-1272	55	25	use	use	NOUN
admet-1272	55	26	.	.	PUNCT
admet-1272	56	1	structure	structure	NOUN
admet-1272	56	2	(	(	PUNCT
admet-1272	56	3	2	2	NUM
admet-1272	56	4	)	)	PUNCT
admet-1272	56	5	,	,	PUNCT
admet-1272	56	6	which	which	PRON
admet-1272	56	7	was	be	AUX
admet-1272	56	8	redrawn	redrawn	VERB
admet-1272	56	9	from	from	ADP
admet-1272	56	10	the	the	DET
admet-1272	56	11	proceedings	proceeding	NOUN
admet-1272	56	12	of	of	ADP
admet-1272	56	13	the	the	DET
admet-1272	56	14	national	national	PROPN
admet-1272	56	15	academy	academy	PROPN
admet-1272	56	16	of	of	ADP
admet-1272	56	17	science	science	PROPN
admet-1272	56	18	paper	paper	NOUN
admet-1272	56	19	by	by	ADP
admet-1272	56	20	okano	okano	PROPN
admet-1272	56	21	et	et	PROPN
admet-1272	56	22	al	al	PROPN
admet-1272	56	23	.	.	PUNCT
admet-1272	57	1	[	[	X
admet-1272	57	2	7	7	X
admet-1272	57	3	]	]	PUNCT
admet-1272	57	4	shows	show	VERB
admet-1272	57	5	the	the	DET
admet-1272	57	6	substitutions	substitution	NOUN
admet-1272	57	7	used	use	VERB
admet-1272	57	8	.	.	PUNCT
admet-1272	58	1	the	the	DET
admet-1272	58	2	compilation	compilation	NOUN
admet-1272	58	3	of	of	ADP
admet-1272	58	4	vancomycin	vancomycin	PROPN
admet-1272	58	5	structural	structural	ADJ
admet-1272	58	6	changes	change	NOUN
admet-1272	58	7	and	and	CCONJ
admet-1272	58	8	the	the	DET
admet-1272	58	9	tables	table	NOUN
admet-1272	58	10	in	in	ADP
admet-1272	58	11	that	that	DET
admet-1272	58	12	report	report	NOUN
admet-1272	58	13	demonstrated	demonstrate	VERB
admet-1272	58	14	how	how	SCONJ
admet-1272	58	15	these	these	DET
admet-1272	58	16	various	various	ADJ
admet-1272	58	17	modifications	modification	NOUN
admet-1272	58	18	“	"	PUNCT
admet-1272	58	19	converted	convert	VERB
admet-1272	58	20	”	"	PUNCT
admet-1272	58	21	total	total	ADJ
admet-1272	58	22	resistance	resistance	NOUN
admet-1272	58	23	to	to	ADP
admet-1272	58	24	e.	e.	PROPN
admet-1272	58	25	faecalis	faecalis	PROPN
admet-1272	58	26	and	and	CCONJ
admet-1272	58	27	e.	e.	PROPN
admet-1272	58	28	faecium	faecium	PROPN
admet-1272	58	29	(	(	PUNCT
admet-1272	58	30	mics	mic	NOUN
admet-1272	58	31	of	of	ADP
admet-1272	58	32	vancomycin	vancomycin	PROPN
admet-1272	58	33	>	>	X
admet-1272	58	34	250	250	NUM
admet-1272	58	35	µg	µg	ADV
admet-1272	58	36	ml-1	ml-1	X
admet-1272	58	37	)	)	PUNCT
admet-1272	58	38	to	to	ADP
admet-1272	58	39	molecules	molecule	NOUN
admet-1272	58	40	with	with	ADP
admet-1272	58	41	mics	mic	NOUN
admet-1272	58	42	from	from	ADP
admet-1272	58	43	5	5	NUM
admet-1272	58	44	to	to	PART
admet-1272	58	45	0.005	0.005	NUM
admet-1272	58	46	µg	µg	ADV
admet-1272	58	47	ml-1	ml-1	ADV
admet-1272	58	48	for	for	ADP
admet-1272	58	49	these	these	DET
admet-1272	58	50	van	van	PROPN
admet-1272	58	51	a	a	NOUN
admet-1272	58	52	/	/	SYM
admet-1272	58	53	e	e	NOUN
admet-1272	58	54	resistant	resistant	ADJ
admet-1272	58	55	microbes	microbe	NOUN
admet-1272	58	56	.	.	PUNCT
admet-1272	59	1	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	AUX
admet-1272	59	2	david	david	PROPN
admet-1272	59	3	j.	j.	PROPN
admet-1272	59	4	newman	newman	PROPN
admet-1272	59	5	admet	admet	PROPN
admet-1272	59	6	&	&	CCONJ
admet-1272	59	7	dmpk	dmpk	PROPN
admet-1272	59	8	10(2	10(2	NUM
admet-1272	59	9	)	)	PUNCT
admet-1272	59	10	(	(	PUNCT
admet-1272	59	11	2022	2022	NUM
admet-1272	59	12	)	)	PUNCT
admet-1272	59	13	131	131	NUM
admet-1272	59	14	-	-	SYM
admet-1272	59	15	146	146	NUM
admet-1272	59	16	134	134	NUM
admet-1272	59	17	then	then	ADV
admet-1272	59	18	in	in	ADP
admet-1272	59	19	2020	2020	NUM
admet-1272	59	20	,	,	PUNCT
admet-1272	59	21	the	the	DET
admet-1272	59	22	same	same	ADJ
admet-1272	59	23	group	group	NOUN
admet-1272	59	24	reported	report	VERB
admet-1272	59	25	the	the	DET
admet-1272	59	26	results	result	NOUN
admet-1272	59	27	of	of	ADP
admet-1272	59	28	further	further	ADJ
admet-1272	59	29	guanidino	guanidino	NOUN
admet-1272	59	30	modifications	modification	NOUN
admet-1272	59	31	on	on	ADP
admet-1272	59	32	the	the	DET
admet-1272	59	33	c	c	NOUN
admet-1272	59	34	-	-	PUNCT
admet-1272	59	35	terminus	terminus	NOUN
admet-1272	59	36	of	of	ADP
admet-1272	59	37	vancomycin	vancomycin	PROPN
admet-1272	59	38	that	that	PRON
admet-1272	59	39	improved	improve	VERB
admet-1272	59	40	antimicrobial	antimicrobial	ADJ
admet-1272	59	41	activity	activity	NOUN
admet-1272	59	42	and	and	CCONJ
admet-1272	59	43	appeared	appear	VERB
admet-1272	59	44	to	to	PART
admet-1272	59	45	provide	provide	VERB
admet-1272	59	46	a	a	DET
admet-1272	59	47	synergistic	synergistic	ADJ
admet-1272	59	48	mechanism	mechanism	NOUN
admet-1272	59	49	of	of	ADP
admet-1272	59	50	action	action	NOUN
admet-1272	59	51	independent	independent	ADJ
admet-1272	59	52	of	of	ADP
admet-1272	59	53	d	d	PROPN
admet-1272	59	54	-	-	PUNCT
admet-1272	59	55	ala	ala	ADP
admet-1272	59	56	-	-	PUNCT
admet-1272	59	57	d	d	NOUN
admet-1272	59	58	-	-	NOUN
admet-1272	59	59	ala	ala	NOUN
admet-1272	60	1	[	[	X
admet-1272	60	2	8	8	NUM
admet-1272	60	3	]	]	PUNCT
admet-1272	60	4	.	.	PUNCT
admet-1272	61	1	by	by	ADP
admet-1272	61	2	using	use	VERB
admet-1272	61	3	structure	structure	NOUN
admet-1272	61	4	(	(	PUNCT
admet-1272	61	5	2	2	NUM
admet-1272	61	6	)	)	PUNCT
admet-1272	61	7	as	as	ADP
admet-1272	61	8	the	the	DET
admet-1272	61	9	base	base	NOUN
admet-1272	61	10	,	,	PUNCT
admet-1272	61	11	then	then	ADV
admet-1272	61	12	coupling	couple	VERB
admet-1272	61	13	the	the	DET
admet-1272	61	14	4chlorobiphenyl)-methyl	4chlorobiphenyl)-methyl	PROPN
admet-1272	61	15	(	(	PUNCT
admet-1272	61	16	cbp	cbp	PROPN
admet-1272	61	17	)	)	PUNCT
admet-1272	61	18	modification	modification	NOUN
admet-1272	61	19	,	,	PUNCT
admet-1272	61	20	which	which	PRON
admet-1272	61	21	they	they	PRON
admet-1272	61	22	had	have	AUX
admet-1272	61	23	previously	previously	ADV
admet-1272	61	24	shown	show	VERB
admet-1272	61	25	to	to	PART
admet-1272	61	26	give	give	VERB
admet-1272	61	27	significant	significant	ADJ
admet-1272	61	28	increases	increase	NOUN
admet-1272	61	29	in	in	ADP
admet-1272	61	30	activity	activity	NOUN
admet-1272	61	31	,	,	PUNCT
admet-1272	61	32	with	with	ADP
admet-1272	61	33	x	x	X
admet-1272	61	34	=	=	PUNCT
admet-1272	61	35	o	o	NOUN
admet-1272	61	36	and	and	CCONJ
admet-1272	61	37	r	r	NOUN
admet-1272	61	38	=	=	PUNCT
admet-1272	61	39	a	a	DET
admet-1272	61	40	variety	variety	NOUN
admet-1272	61	41	of	of	ADP
admet-1272	61	42	guanidino	guanidino	NOUN
admet-1272	61	43	substituents	substituent	NOUN
admet-1272	61	44	,	,	PUNCT
admet-1272	61	45	they	they	PRON
admet-1272	61	46	produced	produce	VERB
admet-1272	61	47	a	a	DET
admet-1272	61	48	series	series	NOUN
admet-1272	61	49	of	of	ADP
admet-1272	61	50	relatively	relatively	ADV
admet-1272	61	51	simple	simple	ADJ
admet-1272	61	52	modified	modify	VERB
admet-1272	61	53	vancomycins	vancomycin	NOUN
admet-1272	61	54	that	that	PRON
admet-1272	61	55	displayed	display	VERB
admet-1272	61	56	sub	sub	ADJ
admet-1272	61	57	-	-	ADJ
admet-1272	61	58	microgram	microgram	ADJ
admet-1272	61	59	activities	activity	NOUN
admet-1272	61	60	(	(	PUNCT
admet-1272	61	61	mic	mic	ADJ
admet-1272	61	62	levels	level	NOUN
admet-1272	61	63	)	)	PUNCT
admet-1272	61	64	against	against	ADP
admet-1272	61	65	significant	significant	ADJ
admet-1272	61	66	vancomycinresistant	vancomycinresistant	ADJ
admet-1272	61	67	clinical	clinical	ADJ
admet-1272	61	68	specimens	specimen	NOUN
admet-1272	61	69	.	.	PUNCT
admet-1272	62	1	the	the	DET
admet-1272	62	2	following	follow	VERB
admet-1272	62	3	is	be	AUX
admet-1272	62	4	a	a	DET
admet-1272	62	5	direct	direct	ADJ
admet-1272	62	6	quote	quote	NOUN
admet-1272	62	7	from	from	ADP
admet-1272	62	8	that	that	DET
admet-1272	62	9	paper	paper	NOUN
admet-1272	62	10	.	.	PUNCT
admet-1272	63	1	“	"	PUNCT
admet-1272	63	2	a	a	DET
admet-1272	63	3	prototypical	prototypical	ADJ
admet-1272	63	4	member	member	NOUN
admet-1272	63	5	of	of	ADP
admet-1272	63	6	the	the	DET
admet-1272	63	7	series	series	NOUN
admet-1272	63	8	,	,	PUNCT
admet-1272	63	9	g3	g3	PROPN
admet-1272	63	10	-	-	PUNCT
admet-1272	63	11	cbpvancomycin	cbpvancomycin	PROPN
admet-1272	63	12	(	(	PUNCT
admet-1272	63	13	15	15	NUM
admet-1272	63	14	)	)	PUNCT
admet-1272	63	15	exhibits	exhibit	VERB
admet-1272	63	16	no	no	DET
admet-1272	63	17	hemolytic	hemolytic	ADJ
admet-1272	63	18	activity	activity	NOUN
admet-1272	63	19	,	,	PUNCT
admet-1272	63	20	displays	display	VERB
admet-1272	63	21	no	no	DET
admet-1272	63	22	mammalian	mammalian	ADJ
admet-1272	63	23	cell	cell	NOUN
admet-1272	63	24	growth	growth	NOUN
admet-1272	63	25	inhibition	inhibition	NOUN
admet-1272	63	26	,	,	PUNCT
admet-1272	63	27	possesses	possesse	NOUN
admet-1272	63	28	improved	improve	VERB
admet-1272	63	29	and	and	CCONJ
admet-1272	63	30	especially	especially	ADV
admet-1272	63	31	attractive	attractive	ADJ
admet-1272	63	32	in	in	ADP
admet-1272	63	33	vivo	vivo	ADJ
admet-1272	63	34	pharmacokinetic	pharmacokinetic	ADJ
admet-1272	63	35	(	(	PUNCT
admet-1272	63	36	pk	pk	NOUN
admet-1272	63	37	)	)	PUNCT
admet-1272	63	38	properties	property	NOUN
admet-1272	63	39	,	,	PUNCT
admet-1272	63	40	and	and	CCONJ
admet-1272	63	41	displays	display	VERB
admet-1272	63	42	excellent	excellent	ADJ
admet-1272	63	43	in	in	ADP
admet-1272	63	44	vivo	vivo	ADJ
admet-1272	63	45	efficacy	efficacy	NOUN
admet-1272	63	46	and	and	CCONJ
admet-1272	63	47	potency	potency	NOUN
admet-1272	63	48	against	against	ADP
admet-1272	63	49	an	an	DET
admet-1272	63	50	especially	especially	ADV
admet-1272	63	51	challenging	challenging	ADJ
admet-1272	63	52	multidrug	multidrug	NOUN
admet-1272	63	53	-	-	PUNCT
admet-1272	63	54	resistant	resistant	ADJ
admet-1272	63	55	(	(	PUNCT
admet-1272	63	56	mrsa	mrsa	NOUN
admet-1272	63	57	)	)	PUNCT
admet-1272	63	58	and	and	CCONJ
admet-1272	63	59	vana	vana	PROPN
admet-1272	63	60	vancomycinresistant	vancomycinresistant	PROPN
admet-1272	63	61	(	(	PUNCT
admet-1272	63	62	vrsa	vrsa	NOUN
admet-1272	63	63	)	)	PUNCT
admet-1272	63	64	staphylococcus	staphylococcus	NOUN
admet-1272	63	65	aureus	aureus	NOUN
admet-1272	63	66	bacterial	bacterial	ADJ
admet-1272	63	67	strain	strain	NOUN
admet-1272	63	68	.	.	PUNCT
admet-1272	63	69	”	"	PUNCT
admet-1272	64	1	the	the	DET
admet-1272	64	2	structure	structure	NOUN
admet-1272	64	3	(	(	PUNCT
admet-1272	64	4	15	15	NUM
admet-1272	64	5	)	)	PUNCT
admet-1272	64	6	mentioned	mention	VERB
admet-1272	64	7	in	in	ADP
admet-1272	64	8	the	the	DET
admet-1272	64	9	direct	direct	ADJ
admet-1272	64	10	quote	quote	NOUN
admet-1272	64	11	above	above	ADV
admet-1272	64	12	from	from	ADP
admet-1272	64	13	wu	wu	PROPN
admet-1272	64	14	et	et	PROPN
admet-1272	64	15	al	al	PROPN
admet-1272	64	16	.	.	PUNCT
admet-1272	65	1	[	[	X
admet-1272	65	2	8	8	NUM
admet-1272	65	3	]	]	PUNCT
admet-1272	65	4	is	be	AUX
admet-1272	65	5	shown	show	VERB
admet-1272	65	6	as	as	ADP
admet-1272	65	7	structure	structure	NOUN
admet-1272	65	8	(	(	PUNCT
admet-1272	65	9	3	3	NUM
admet-1272	65	10	)	)	PUNCT
admet-1272	65	11	in	in	ADP
admet-1272	65	12	figure	figure	NOUN
admet-1272	65	13	1	1	NUM
admet-1272	65	14	.	.	PUNCT
admet-1272	65	15	figure	figure	NOUN
admet-1272	65	16	1	1	NUM
admet-1272	65	17	.	.	PUNCT
admet-1272	66	1	vancomycin	vancomycin	PROPN
admet-1272	66	2	and	and	CCONJ
admet-1272	66	3	boger	boger	PROPN
admet-1272	66	4	lab	lab	NOUN
admet-1272	66	5	modifications	modification	NOUN
admet-1272	66	6	;	;	PUNCT
admet-1272	66	7	structures	structure	NOUN
admet-1272	66	8	1	1	NUM
admet-1272	66	9	to	to	PART
admet-1272	66	10	3	3	NUM
admet-1272	66	11	admet	admet	X
admet-1272	66	12	&	&	CCONJ
admet-1272	66	13	dmpk	dmpk	PROPN
admet-1272	66	14	10(2	10(2	NUM
admet-1272	66	15	)	)	PUNCT
admet-1272	66	16	(	(	PUNCT
admet-1272	66	17	2022	2022	NUM
admet-1272	66	18	)	)	PUNCT
admet-1272	66	19	131	131	NUM
admet-1272	66	20	-	-	SYM
admet-1272	66	21	146	146	NUM
admet-1272	66	22	chemical	chemical	NOUN
admet-1272	66	23	syntheses	synthesis	NOUN
admet-1272	66	24	and	and	CCONJ
admet-1272	66	25	resistant	resistant	ADJ
admet-1272	66	26	antibiotics	antibiotic	NOUN
admet-1272	66	27	doi	doi	NOUN
admet-1272	66	28	:	:	PUNCT
admet-1272	66	29	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	NOUN
admet-1272	66	30	135	135	NUM
admet-1272	66	31	in	in	ADP
admet-1272	66	32	addition	addition	NOUN
admet-1272	66	33	to	to	ADP
admet-1272	66	34	the	the	DET
admet-1272	66	35	papers	paper	NOUN
admet-1272	66	36	referred	refer	VERB
admet-1272	66	37	to	to	ADP
admet-1272	66	38	above	above	ADV
admet-1272	66	39	,	,	PUNCT
admet-1272	66	40	another	another	DET
admet-1272	66	41	recent	recent	ADJ
admet-1272	66	42	paper	paper	NOUN
admet-1272	66	43	from	from	ADP
admet-1272	66	44	the	the	DET
admet-1272	66	45	boger	boger	ADJ
admet-1272	66	46	lab	lab	NOUN
admet-1272	67	1	[	[	X
admet-1272	67	2	9	9	NUM
admet-1272	67	3	]	]	PUNCT
admet-1272	67	4	gives	give	VERB
admet-1272	67	5	an	an	DET
admet-1272	67	6	excellent	excellent	ADJ
admet-1272	67	7	precis	precis	NOUN
admet-1272	67	8	of	of	ADP
admet-1272	67	9	the	the	DET
admet-1272	67	10	modified	modify	VERB
admet-1272	67	11	vancomycin	vancomycin	PROPN
admet-1272	67	12	derivatives	derivative	NOUN
admet-1272	67	13	mentioned	mention	VERB
admet-1272	67	14	above	above	ADV
admet-1272	67	15	,	,	PUNCT
admet-1272	67	16	plus	plus	CCONJ
admet-1272	67	17	others	other	NOUN
admet-1272	67	18	from	from	ADP
admet-1272	67	19	the	the	DET
admet-1272	67	20	boger	boger	ADJ
admet-1272	67	21	lab	lab	NOUN
admet-1272	67	22	.	.	PUNCT
admet-1272	68	1	they	they	PRON
admet-1272	68	2	comment	comment	VERB
admet-1272	68	3	that	that	SCONJ
admet-1272	68	4	these	these	DET
admet-1272	68	5	agents	agent	NOUN
admet-1272	68	6	are	be	AUX
admet-1272	68	7	now	now	ADV
admet-1272	68	8	known	know	VERB
admet-1272	68	9	in	in	ADP
admet-1272	68	10	that	that	DET
admet-1272	68	11	laboratory	laboratory	NOUN
admet-1272	68	12	as	as	ADP
admet-1272	68	13	“	"	PUNCT
admet-1272	68	14	maxamycins	maxamycin	NOUN
admet-1272	68	15	”	"	PUNCT
admet-1272	68	16	.	.	PUNCT
admet-1272	69	1	this	this	DET
admet-1272	69	2	paper	paper	NOUN
admet-1272	69	3	is	be	AUX
admet-1272	69	4	well	well	ADV
admet-1272	69	5	worth	worth	ADJ
admet-1272	69	6	reading	read	VERB
admet-1272	69	7	to	to	PART
admet-1272	69	8	gain	gain	VERB
admet-1272	69	9	further	further	ADJ
admet-1272	69	10	insight	insight	NOUN
admet-1272	69	11	into	into	ADP
admet-1272	69	12	these	these	DET
admet-1272	69	13	chemical	chemical	ADJ
admet-1272	69	14	modifications	modification	NOUN
admet-1272	69	15	of	of	ADP
admet-1272	69	16	a	a	DET
admet-1272	69	17	microbial	microbial	ADJ
admet-1272	69	18	product	product	NOUN
admet-1272	69	19	that	that	PRON
admet-1272	69	20	first	first	ADV
admet-1272	69	21	saw	see	VERB
admet-1272	69	22	“	"	PUNCT
admet-1272	69	23	light	light	NOUN
admet-1272	69	24	of	of	ADP
admet-1272	69	25	day	day	NOUN
admet-1272	69	26	”	"	PUNCT
admet-1272	69	27	in	in	ADP
admet-1272	69	28	the	the	DET
admet-1272	69	29	middle	middle	NOUN
admet-1272	69	30	to	to	ADP
admet-1272	69	31	late	late	ADJ
admet-1272	69	32	1950s	1950s	NUM
admet-1272	69	33	,	,	PUNCT
admet-1272	69	34	in	in	ADP
admet-1272	69	35	order	order	NOUN
admet-1272	69	36	to	to	PART
admet-1272	69	37	overcome	overcome	VERB
admet-1272	69	38	microbial	microbial	ADJ
admet-1272	69	39	resistance	resistance	NOUN
admet-1272	69	40	.	.	PUNCT
admet-1272	70	1	a	a	DET
admet-1272	70	2	comment	comment	NOUN
admet-1272	70	3	on	on	ADP
admet-1272	70	4	modern	modern	ADJ
admet-1272	70	5	synthetic	synthetic	ADJ
admet-1272	70	6	methods	method	NOUN
admet-1272	70	7	as	as	ADP
admet-1272	70	8	a	a	DET
admet-1272	70	9	route(s	route(s	NOUN
admet-1272	70	10	)	)	PUNCT
admet-1272	70	11	to	to	PART
admet-1272	70	12	cgmp	cgmp	PROPN
admet-1272	70	13	product(s	product(s	PROPN
admet-1272	70	14	)	)	PUNCT
admet-1272	70	15	it	it	PRON
admet-1272	70	16	should	should	AUX
admet-1272	70	17	be	be	AUX
admet-1272	70	18	emphasized	emphasize	VERB
admet-1272	70	19	at	at	ADP
admet-1272	70	20	this	this	DET
admet-1272	70	21	juncture	juncture	NOUN
admet-1272	70	22	that	that	PRON
admet-1272	70	23	synthetic	synthetic	ADJ
admet-1272	70	24	organic	organic	ADJ
admet-1272	70	25	chemists	chemist	NOUN
admet-1272	70	26	have	have	AUX
admet-1272	70	27	succeeded	succeed	VERB
admet-1272	70	28	in	in	ADP
admet-1272	70	29	the	the	DET
admet-1272	70	30	last	last	ADJ
admet-1272	70	31	few	few	ADJ
admet-1272	70	32	years	year	NOUN
admet-1272	70	33	in	in	ADP
admet-1272	70	34	producing	produce	VERB
admet-1272	70	35	large	large	ADJ
admet-1272	70	36	quantities	quantity	NOUN
admet-1272	70	37	of	of	ADP
admet-1272	70	38	cgmp	cgmp	NOUN
admet-1272	70	39	-	-	NOUN
admet-1272	70	40	quality	quality	ADJ
admet-1272	70	41	,	,	PUNCT
admet-1272	70	42	partial	partial	ADJ
admet-1272	70	43	or	or	CCONJ
admet-1272	70	44	complete	complete	ADJ
admet-1272	70	45	natural	natural	ADJ
admet-1272	70	46	products	product	NOUN
admet-1272	70	47	that	that	PRON
admet-1272	70	48	have	have	AUX
admet-1272	70	49	either	either	CCONJ
admet-1272	70	50	become	become	VERB
admet-1272	70	51	drugs	drug	NOUN
admet-1272	70	52	,	,	PUNCT
admet-1272	70	53	eribulin	eribulin	NOUN
admet-1272	70	54	(	(	PUNCT
admet-1272	70	55	4	4	NUM
admet-1272	70	56	)	)	PUNCT
admet-1272	70	57	mw	mw	NOUN
admet-1272	70	58	730	730	NUM
admet-1272	70	59	being	be	AUX
admet-1272	70	60	the	the	DET
admet-1272	70	61	prime	prime	ADJ
admet-1272	70	62	example	example	NOUN
admet-1272	70	63	utilizing	utilize	VERB
admet-1272	70	64	data	datum	NOUN
admet-1272	70	65	from	from	ADP
admet-1272	70	66	the	the	DET
admet-1272	70	67	kishi	kishi	PROPN
admet-1272	70	68	synthesis	synthesis	NOUN
admet-1272	70	69	of	of	ADP
admet-1272	70	70	halichondrin	halichondrin	NOUN
admet-1272	70	71	b	b	PROPN
admet-1272	70	72	(	(	PUNCT
admet-1272	70	73	5	5	NUM
admet-1272	70	74	)	)	PUNCT
admet-1272	70	75	mw	mw	X
admet-1272	70	76	1111	1111	NUM
admet-1272	70	77	.	.	PUNCT
admet-1272	71	1	or	or	CCONJ
admet-1272	71	2	nowadays	nowadays	ADV
admet-1272	71	3	as	as	SCONJ
admet-1272	71	4	potential	potential	ADJ
admet-1272	71	5	leads	lead	NOUN
admet-1272	71	6	to	to	ADP
admet-1272	71	7	drugs	drug	NOUN
admet-1272	71	8	,	,	PUNCT
admet-1272	71	9	with	with	ADP
admet-1272	71	10	the	the	DET
admet-1272	71	11	total	total	ADJ
admet-1272	71	12	synthesis	synthesis	NOUN
admet-1272	71	13	of	of	ADP
admet-1272	71	14	a	a	DET
admet-1272	71	15	derivative	derivative	NOUN
admet-1272	71	16	of	of	ADP
admet-1272	71	17	halichondrin	halichondrin	NOUN
admet-1272	71	18	b	b	X
admet-1272	71	19	e7130	e7130	ADJ
admet-1272	71	20	(	(	PUNCT
admet-1272	71	21	6	6	NUM
admet-1272	71	22	)	)	PUNCT
admet-1272	71	23	;	;	PUNCT
admet-1272	71	24	mw	mw	X
admet-1272	71	25	1111	1111	NUM
admet-1272	71	26	at	at	ADP
admet-1272	71	27	the	the	DET
admet-1272	71	28	10	10	NUM
admet-1272	71	29	-	-	PUNCT
admet-1272	71	30	gram	gram	NOUN
admet-1272	71	31	level	level	NOUN
admet-1272	71	32	,	,	PUNCT
admet-1272	71	33	reported	report	VERB
admet-1272	71	34	by	by	ADP
admet-1272	71	35	the	the	DET
admet-1272	71	36	same	same	ADJ
admet-1272	71	37	eisai	eisai	PROPN
admet-1272	71	38	group	group	NOUN
admet-1272	71	39	that	that	PRON
admet-1272	71	40	synthesized	synthesize	VERB
admet-1272	71	41	eribulin	eribulin	NOUN
admet-1272	71	42	[	[	X
admet-1272	71	43	10	10	NUM
admet-1272	71	44	]	]	PUNCT
admet-1272	71	45	,	,	PUNCT
admet-1272	71	46	which	which	PRON
admet-1272	71	47	is	be	AUX
admet-1272	71	48	currently	currently	ADV
admet-1272	71	49	in	in	ADP
admet-1272	71	50	phase	phase	NOUN
admet-1272	71	51	i	i	PRON
admet-1272	71	52	clinical	clinical	ADJ
admet-1272	71	53	trials	trial	NOUN
admet-1272	71	54	.	.	PUNCT
admet-1272	72	1	these	these	DET
admet-1272	72	2	structures	structure	NOUN
admet-1272	72	3	are	be	AUX
admet-1272	72	4	shown	show	VERB
admet-1272	72	5	in	in	ADP
admet-1272	72	6	figure	figure	NOUN
admet-1272	72	7	2	2	NUM
admet-1272	72	8	.	.	PUNCT
admet-1272	72	9	figure	figure	NOUN
admet-1272	72	10	2	2	NUM
admet-1272	72	11	.	.	PUNCT
admet-1272	72	12	halichondrin	halichondrin	PROPN
admet-1272	72	13	b	b	PROPN
admet-1272	72	14	and	and	CCONJ
admet-1272	72	15	synthetic	synthetic	ADJ
admet-1272	72	16	derivatives	derivative	NOUN
admet-1272	72	17	;	;	PUNCT
admet-1272	72	18	structures	structure	NOUN
admet-1272	72	19	4	4	NUM
admet-1272	72	20	to	to	PART
admet-1272	72	21	6	6	NUM
admet-1272	72	22	tetracycline	tetracycline	NOUN
admet-1272	72	23	-	-	PUNCT
admet-1272	72	24	like	like	ADJ
admet-1272	72	25	molecules	molecule	NOUN
admet-1272	72	26	rather	rather	ADV
admet-1272	72	27	than	than	ADP
admet-1272	72	28	cover	cover	VERB
admet-1272	72	29	the	the	DET
admet-1272	72	30	modified	modify	VERB
admet-1272	72	31	tetracyclines	tetracyclines	PROPN
admet-1272	72	32	omadacycline	omadacycline	NOUN
admet-1272	72	33	,	,	PUNCT
admet-1272	72	34	eravacycline	eravacycline	NOUN
admet-1272	72	35	and	and	CCONJ
admet-1272	72	36	saracycline	saracycline	NOUN
admet-1272	72	37	(	(	PUNCT
admet-1272	72	38	structures	structure	NOUN
admet-1272	72	39	not	not	PART
admet-1272	72	40	given	give	VERB
admet-1272	72	41	)	)	PUNCT
admet-1272	72	42	,	,	PUNCT
admet-1272	72	43	that	that	PRON
admet-1272	72	44	came	come	VERB
admet-1272	72	45	from	from	ADP
admet-1272	72	46	the	the	DET
admet-1272	72	47	lederle	lederle	NOUN
admet-1272	72	48	(	(	PUNCT
admet-1272	72	49	then	then	ADV
admet-1272	72	50	wyeth	wyeth	PROPN
admet-1272	72	51	and	and	CCONJ
admet-1272	72	52	now	now	ADV
admet-1272	72	53	pfizer	pfizer	NOUN
admet-1272	72	54	)	)	PUNCT
admet-1272	72	55	laboratories	laboratory	NOUN
admet-1272	72	56	in	in	ADP
admet-1272	72	57	the	the	DET
admet-1272	72	58	1990s	1990	NOUN
admet-1272	72	59	with	with	ADP
admet-1272	72	60	these	these	DET
admet-1272	72	61	variations	variation	NOUN
admet-1272	72	62	being	be	AUX
admet-1272	72	63	approved	approve	VERB
admet-1272	72	64	as	as	ADP
admet-1272	72	65	drugs	drug	NOUN
admet-1272	72	66	in	in	ADP
admet-1272	72	67	2018	2018	NUM
admet-1272	72	68	,	,	PUNCT
admet-1272	72	69	there	there	PRON
admet-1272	72	70	were	be	VERB
admet-1272	72	71	two	two	NUM
admet-1272	72	72	compounds	compound	NOUN
admet-1272	72	73	reported	report	VERB
admet-1272	72	74	that	that	PRON
admet-1272	72	75	had	have	VERB
admet-1272	72	76	the	the	DET
admet-1272	72	77	basic	basic	ADJ
admet-1272	72	78	nucleus	nucleus	NOUN
admet-1272	72	79	of	of	ADP
admet-1272	72	80	the	the	DET
admet-1272	72	81	tetracyclines	tetracycline	NOUN
admet-1272	72	82	but	but	CCONJ
admet-1272	72	83	with	with	ADP
admet-1272	72	84	extensions	extension	NOUN
admet-1272	72	85	on	on	ADP
admet-1272	72	86	the	the	DET
admet-1272	72	87	base	base	ADJ
admet-1272	72	88	four	four	NUM
admet-1272	72	89	-	-	PUNCT
admet-1272	72	90	ring	ring	NOUN
admet-1272	72	91	scaffold	scaffold	NOUN
admet-1272	72	92	.	.	PUNCT
admet-1272	73	1	these	these	DET
admet-1272	73	2	compounds	compound	NOUN
admet-1272	73	3	were	be	AUX
admet-1272	73	4	the	the	DET
admet-1272	73	5	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	73	6	,	,	PUNCT
admet-1272	73	7	now	now	ADV
admet-1272	73	8	known	know	VERB
admet-1272	73	9	as	as	ADP
admet-1272	73	10	a	a	DET
admet-1272	73	11	(	(	PUNCT
admet-1272	73	12	7	7	NUM
admet-1272	73	13	)	)	PUNCT
admet-1272	73	14	and	and	CCONJ
admet-1272	73	15	b	b	X
admet-1272	73	16	(	(	PUNCT
admet-1272	73	17	8)	8)	NUM
admet-1272	73	18	.	.	PUNCT
admet-1272	74	1	they	they	PRON
admet-1272	74	2	were	be	AUX
admet-1272	74	3	first	first	ADV
admet-1272	74	4	reported	report	VERB
admet-1272	74	5	by	by	ADP
admet-1272	74	6	hutchinson	hutchinson	PROPN
admet-1272	74	7	et	et	PROPN
admet-1272	74	8	al	al	PROPN
admet-1272	74	9	.	.	PROPN
admet-1272	75	1	in	in	ADP
admet-1272	75	2	1973	1973	NUM
admet-1272	75	3	from	from	ADP
admet-1272	75	4	the	the	DET
admet-1272	75	5	fungus	fungus	NOUN
admet-1272	75	6	penicillium	penicillium	NOUN
admet-1272	75	7	viridicatum	viridicatum	NOUN
admet-1272	76	1	[	[	X
admet-1272	76	2	11	11	NUM
admet-1272	76	3	]	]	PUNCT
admet-1272	76	4	as	as	ADP
admet-1272	76	5	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	76	6	.	.	PUNCT
admet-1272	77	1	subsequently	subsequently	ADV
admet-1272	77	2	the	the	DET
admet-1272	77	3	b	b	PROPN
admet-1272	77	4	variant	variant	NOUN
admet-1272	77	5	was	be	AUX
admet-1272	77	6	reported	report	VERB
admet-1272	77	7	by	by	ADP
admet-1272	77	8	zheng	zheng	PROPN
admet-1272	77	9	et	et	PROPN
admet-1272	77	10	al	al	PROPN
admet-1272	77	11	.	.	PROPN
admet-1272	78	1	in	in	ADP
admet-1272	78	2	2008	2008	NUM
admet-1272	78	3	[	[	X
admet-1272	78	4	12	12	NUM
admet-1272	78	5	]	]	PUNCT
admet-1272	78	6	,	,	PUNCT
admet-1272	78	7	and	and	CCONJ
admet-1272	78	8	the	the	DET
admet-1272	78	9	synthesis	synthesis	NOUN
admet-1272	78	10	of	of	ADP
admet-1272	78	11	the	the	DET
admet-1272	78	12	b	b	PROPN
admet-1272	78	13	(	(	PUNCT
admet-1272	78	14	8)	8)	NUM
admet-1272	78	15	variant	variant	NOUN
admet-1272	78	16	was	be	AUX
admet-1272	78	17	originally	originally	ADV
admet-1272	78	18	reported	report	VERB
admet-1272	78	19	by	by	ADP
admet-1272	78	20	the	the	DET
admet-1272	78	21	nicolaou	nicolaou	ADJ
admet-1272	78	22	group	group	NOUN
admet-1272	78	23	in	in	ADP
admet-1272	78	24	2013	2013	NUM
admet-1272	78	25	,	,	PUNCT
admet-1272	79	1	[	[	X
admet-1272	79	2	13	13	NUM
admet-1272	79	3	]	]	PUNCT
admet-1272	79	4	with	with	ADP
admet-1272	79	5	a	a	DET
admet-1272	79	6	subsequent	subsequent	ADJ
admet-1272	79	7	structure	structure	NOUN
admet-1272	79	8	revision	revision	NOUN
admet-1272	79	9	and	and	CCONJ
admet-1272	79	10	syntheses	synthesis	NOUN
admet-1272	79	11	of	of	ADP
admet-1272	79	12	related	related	ADJ
admet-1272	79	13	“	"	PUNCT
admet-1272	79	14	microbiologically	microbiologically	ADV
admet-1272	79	15	active	active	ADJ
admet-1272	79	16	compounds	compound	NOUN
admet-1272	79	17	”	"	PUNCT
admet-1272	79	18	in	in	ADP
admet-1272	79	19	2014	2014	NUM
admet-1272	80	1	[	[	X
admet-1272	80	2	14	14	NUM
admet-1272	80	3	]	]	PUNCT
admet-1272	80	4	.	.	PUNCT
admet-1272	81	1	this	this	DET
admet-1272	81	2	molecule	molecule	NOUN
admet-1272	81	3	(	(	PUNCT
admet-1272	81	4	as	as	ADP
admet-1272	81	5	the	the	DET
admet-1272	81	6	mixture	mixture	NOUN
admet-1272	81	7	of	of	ADP
admet-1272	81	8	enantiomers	enantiomer	NOUN
admet-1272	81	9	)	)	PUNCT
admet-1272	81	10	was	be	AUX
admet-1272	81	11	significantly	significantly	ADV
admet-1272	81	12	active	active	ADJ
admet-1272	81	13	against	against	ADP
admet-1272	81	14	resistant	resistant	ADJ
admet-1272	81	15	strains	strain	NOUN
admet-1272	81	16	of	of	ADP
admet-1272	81	17	e.	e.	PROPN
admet-1272	81	18	faecalis	faecalis	PROPN
admet-1272	81	19	,	,	PUNCT
admet-1272	81	20	e.	e.	PROPN
admet-1272	81	21	faecium	faecium	PROPN
admet-1272	81	22	and	and	CCONJ
admet-1272	81	23	mrsa	mrsa	NOUN
admet-1272	81	24	,	,	PUNCT
admet-1272	81	25	and	and	CCONJ
admet-1272	81	26	the	the	DET
admet-1272	81	27	natural	natural	ADJ
admet-1272	81	28	a	a	DET
admet-1272	81	29	isomer	isomer	NOUN
admet-1272	81	30	was	be	AUX
admet-1272	81	31	comparably	comparably	ADV
admet-1272	81	32	active	active	ADJ
admet-1272	81	33	against	against	ADP
admet-1272	81	34	the	the	DET
admet-1272	81	35	same	same	ADJ
admet-1272	81	36	strains	strain	NOUN
admet-1272	81	37	.	.	PUNCT
admet-1272	82	1	recently	recently	ADV
admet-1272	82	2	the	the	DET
admet-1272	82	3	biosynthtetic	biosynthtetic	ADJ
admet-1272	82	4	gene	gene	NOUN
admet-1272	82	5	cluster	cluster	NOUN
admet-1272	82	6	(	(	PUNCT
admet-1272	82	7	bgc	bgc	NOUN
admet-1272	82	8	)	)	PUNCT
admet-1272	82	9	for	for	ADP
admet-1272	82	10	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	82	11	was	be	AUX
admet-1272	82	12	identified	identify	VERB
admet-1272	82	13	in	in	ADP
admet-1272	82	14	a.	a.	NOUN
admet-1272	82	15	nidulans	nidulans	PROPN
admet-1272	82	16	,	,	PUNCT
admet-1272	82	17	a	a	DET
admet-1272	82	18	fungus	fungus	NOUN
admet-1272	82	19	not	not	PART
admet-1272	82	20	previously	previously	ADV
admet-1272	82	21	reported	report	VERB
admet-1272	82	22	to	to	PART
admet-1272	82	23	produce	produce	VERB
admet-1272	82	24	this	this	DET
admet-1272	82	25	agent	agent	NOUN
admet-1272	82	26	.	.	PUNCT
admet-1272	83	1	that	that	DET
admet-1272	83	2	report	report	NOUN
admet-1272	83	3	also	also	ADV
admet-1272	83	4	identified	identify	VERB
admet-1272	83	5	the	the	DET
admet-1272	83	6	same	same	ADJ
admet-1272	83	7	cluster	cluster	NOUN
admet-1272	83	8	in	in	ADP
admet-1272	83	9	p.	p.	PROPN
admet-1272	83	10	brasilianum	brasilianum	PROPN
admet-1272	83	11	and	and	CCONJ
admet-1272	83	12	in	in	ADP
admet-1272	83	13	three	three	NUM
admet-1272	83	14	other	other	ADJ
admet-1272	83	15	aspergillus	aspergillus	NOUN
admet-1272	83	16	spp	spp	NOUN
admet-1272	84	1	[	[	X
admet-1272	84	2	15	15	NUM
admet-1272	84	3	]	]	PUNCT
admet-1272	84	4	.	.	PUNCT
admet-1272	85	1	interestingly	interestingly	ADV
admet-1272	85	2	,	,	PUNCT
admet-1272	85	3	the	the	DET
admet-1272	85	4	capon	capon	NOUN
admet-1272	85	5	group	group	NOUN
admet-1272	85	6	at	at	ADP
admet-1272	85	7	the	the	DET
admet-1272	85	8	university	university	PROPN
admet-1272	85	9	of	of	ADP
admet-1272	85	10	queensland	queensland	PROPN
admet-1272	85	11	reported	report	VERB
admet-1272	85	12	five	five	NUM
admet-1272	85	13	years	year	NOUN
admet-1272	85	14	earlier	early	ADV
admet-1272	85	15	in	in	ADP
admet-1272	85	16	2015	2015	NUM
admet-1272	85	17	,	,	PUNCT
admet-1272	85	18	that	that	SCONJ
admet-1272	85	19	the	the	DET
admet-1272	85	20	paecilomyces	paecilomyce	NOUN
admet-1272	85	21	sp	sp	PROPN
admet-1272	85	22	.	.	PROPN
admet-1272	85	23	,	,	PUNCT
admet-1272	85	24	known	know	VERB
admet-1272	85	25	as	as	ADP
admet-1272	85	26	cmb	cmb	PROPN
admet-1272	85	27	-	-	PUNCT
admet-1272	85	28	mf010	mf010	PROPN
admet-1272	85	29	,	,	PUNCT
admet-1272	85	30	which	which	PRON
admet-1272	85	31	they	they	PRON
admet-1272	85	32	had	have	AUX
admet-1272	85	33	isolated	isolate	VERB
admet-1272	85	34	from	from	ADP
admet-1272	85	35	the	the	DET
admet-1272	85	36	inner	inner	ADJ
admet-1272	85	37	tissues	tissue	NOUN
admet-1272	85	38	of	of	ADP
admet-1272	85	39	the	the	DET
admet-1272	85	40	intertidal	intertidal	NOUN
admet-1272	85	41	pulmonated	pulmonate	VERB
admet-1272	85	42	mollusk	mollusk	NOUN
admet-1272	85	43	siphonaria	siphonaria	PROPN
admet-1272	85	44	sp	sp	PROPN
admet-1272	85	45	.	.	PROPN
admet-1272	85	46	,	,	PUNCT
admet-1272	85	47	yielded	yield	VERB
admet-1272	85	48	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	85	49	a	a	DET
admet-1272	85	50	(	(	PUNCT
admet-1272	85	51	7	7	NUM
admet-1272	85	52	)	)	PUNCT
admet-1272	85	53	and	and	CCONJ
admet-1272	85	54	b	b	PROPN
admet-1272	85	55	(	(	PUNCT
admet-1272	85	56	8)	8)	NUM
admet-1272	85	57	and	and	CCONJ
admet-1272	85	58	the	the	DET
admet-1272	85	59	new	new	ADJ
admet-1272	85	60	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	85	61	cf	cf	X
admet-1272	85	62	(	(	PUNCT
admet-1272	85	63	9	9	NUM
admet-1272	85	64	-	-	SYM
admet-1272	85	65	12	12	NUM
admet-1272	85	66	)	)	PUNCT
admet-1272	85	67	,	,	PUNCT
admet-1272	85	68	and	and	CCONJ
admet-1272	85	69	spirohexaline	spirohexaline	PROPN
admet-1272	85	70	(	(	PUNCT
admet-1272	85	71	structure	structure	NOUN
admet-1272	85	72	not	not	PART
admet-1272	85	73	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	VERB
admet-1272	85	74	david	david	PROPN
admet-1272	85	75	j.	j.	PROPN
admet-1272	85	76	newman	newman	PROPN
admet-1272	85	77	admet	admet	PROPN
admet-1272	85	78	&	&	CCONJ
admet-1272	85	79	dmpk	dmpk	PROPN
admet-1272	85	80	10(2	10(2	NUM
admet-1272	85	81	)	)	PUNCT
admet-1272	85	82	(	(	PUNCT
admet-1272	85	83	2022	2022	NUM
admet-1272	85	84	)	)	PUNCT
admet-1272	85	85	131	131	NUM
admet-1272	85	86	-	-	SYM
admet-1272	85	87	146	146	NUM
admet-1272	85	88	136	136	NUM
admet-1272	85	89	given	give	VERB
admet-1272	85	90	)	)	PUNCT
admet-1272	85	91	.	.	PUNCT
admet-1272	86	1	of	of	ADP
admet-1272	86	2	these	these	DET
admet-1272	86	3	compounds	compound	NOUN
admet-1272	86	4	,	,	PUNCT
admet-1272	86	5	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	86	6	b	b	X
admet-1272	86	7	(	(	PUNCT
admet-1272	86	8	8)	8)	NUM
admet-1272	86	9	and	and	CCONJ
admet-1272	86	10	c	c	PROPN
admet-1272	86	11	(	(	PUNCT
admet-1272	86	12	9	9	NUM
admet-1272	86	13	)	)	PUNCT
admet-1272	86	14	demonstrated	demonstrate	VERB
admet-1272	86	15	the	the	DET
admet-1272	86	16	largest	large	ADJ
admet-1272	86	17	separation	separation	NOUN
admet-1272	86	18	of	of	ADP
admet-1272	86	19	antimicrobial	antimicrobial	ADJ
admet-1272	86	20	activity	activity	NOUN
admet-1272	86	21	versus	versus	ADP
admet-1272	86	22	cell	cell	NOUN
admet-1272	86	23	-	-	PUNCT
admet-1272	86	24	line	line	NOUN
admet-1272	86	25	cytotoxicity	cytotoxicity	NOUN
admet-1272	86	26	with	with	ADP
admet-1272	86	27	between	between	ADP
admet-1272	86	28	15	15	NUM
admet-1272	86	29	-	-	PUNCT
admet-1272	86	30	to-40	to-40	ADP
admet-1272	86	31	-	-	PUNCT
admet-1272	86	32	fold	fold	ADJ
admet-1272	86	33	differences	difference	NOUN
admet-1272	86	34	in	in	ADP
admet-1272	86	35	favor	favor	NOUN
admet-1272	86	36	of	of	ADP
admet-1272	86	37	the	the	DET
admet-1272	86	38	antimicrobial	antimicrobial	ADJ
admet-1272	86	39	activity	activity	NOUN
admet-1272	86	40	.	.	PUNCT
admet-1272	87	1	of	of	ADP
admet-1272	87	2	the	the	DET
admet-1272	87	3	six	six	NUM
admet-1272	87	4	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	87	5	,	,	PUNCT
admet-1272	87	6	a	a	DET
admet-1272	87	7	(	(	PUNCT
admet-1272	87	8	7	7	NUM
admet-1272	87	9	)	)	PUNCT
admet-1272	87	10	and	and	CCONJ
admet-1272	87	11	b	b	X
admet-1272	87	12	(	(	PUNCT
admet-1272	87	13	8)	8)	NUM
admet-1272	87	14	were	be	AUX
admet-1272	87	15	the	the	DET
admet-1272	87	16	most	most	ADV
admet-1272	87	17	active	active	ADJ
admet-1272	87	18	against	against	ADP
admet-1272	87	19	mrsa	mrsa	NOUN
admet-1272	87	20	and	and	CCONJ
admet-1272	87	21	vancomycin	vancomycin	NOUN
admet-1272	87	22	-	-	PUNCT
admet-1272	87	23	resistant	resistant	ADJ
admet-1272	87	24	e.	e.	PROPN
admet-1272	87	25	faecalis	faecalis	PROPN
admet-1272	87	26	.	.	PUNCT
admet-1272	88	1	what	what	PRON
admet-1272	88	2	is	be	AUX
admet-1272	88	3	also	also	ADV
admet-1272	88	4	of	of	ADP
admet-1272	88	5	interest	interest	NOUN
admet-1272	88	6	is	be	AUX
admet-1272	88	7	that	that	SCONJ
admet-1272	88	8	the	the	DET
admet-1272	88	9	capon	capon	NOUN
admet-1272	88	10	group	group	NOUN
admet-1272	88	11	demonstrated	demonstrate	VERB
admet-1272	88	12	that	that	SCONJ
admet-1272	88	13	“	"	PUNCT
admet-1272	88	14	regular	regular	ADJ
admet-1272	88	15	tetracyclines	tetracycline	NOUN
admet-1272	88	16	”	"	PUNCT
admet-1272	88	17	could	could	AUX
admet-1272	88	18	be	be	AUX
admet-1272	88	19	transformed	transform	VERB
admet-1272	88	20	by	by	ADP
admet-1272	88	21	ring	ring	NOUN
admet-1272	88	22	-	-	PUNCT
admet-1272	88	23	opening	opening	NOUN
admet-1272	88	24	by	by	ADP
admet-1272	88	25	the	the	DET
admet-1272	88	26	paecilomyces	paecilomyce	NOUN
admet-1272	88	27	sp	sp	PROPN
admet-1272	88	28	.	.	PROPN
admet-1272	88	29	,	,	PUNCT
admet-1272	88	30	mentioned	mention	VERB
admet-1272	88	31	above	above	ADV
admet-1272	88	32	,	,	PUNCT
admet-1272	88	33	perhaps	perhaps	ADV
admet-1272	88	34	demonstrating	demonstrate	VERB
admet-1272	88	35	a	a	DET
admet-1272	88	36	resistance	resistance	NOUN
admet-1272	88	37	methodology	methodology	NOUN
admet-1272	88	38	by	by	ADP
admet-1272	88	39	fungi	fungus	NOUN
admet-1272	88	40	against	against	ADP
admet-1272	88	41	these	these	DET
admet-1272	88	42	molecules	molecule	NOUN
admet-1272	88	43	,	,	PUNCT
admet-1272	88	44	since	since	SCONJ
admet-1272	88	45	none	none	NOUN
admet-1272	88	46	of	of	ADP
admet-1272	88	47	the	the	DET
admet-1272	88	48	modified	modify	VERB
admet-1272	88	49	agents	agent	NOUN
admet-1272	88	50	demonstrated	demonstrate	VERB
admet-1272	88	51	any	any	DET
admet-1272	88	52	significant	significant	ADJ
admet-1272	88	53	bioactivity	bioactivity	NOUN
admet-1272	89	1	[	[	X
admet-1272	89	2	16	16	NUM
admet-1272	89	3	]	]	PUNCT
admet-1272	89	4	.	.	PUNCT
admet-1272	90	1	in	in	ADP
admet-1272	90	2	2020	2020	NUM
admet-1272	90	3	,	,	PUNCT
admet-1272	90	4	the	the	DET
admet-1272	90	5	antibacterial	antibacterial	ADJ
admet-1272	90	6	mechanism	mechanism	NOUN
admet-1272	90	7	of	of	ADP
admet-1272	90	8	these	these	DET
admet-1272	90	9	agents	agent	NOUN
admet-1272	90	10	was	be	AUX
admet-1272	90	11	proven	prove	VERB
admet-1272	90	12	by	by	ADP
admet-1272	90	13	li	li	PROPN
admet-1272	90	14	et	et	PROPN
admet-1272	90	15	al	al	PROPN
admet-1272	90	16	.	.	PROPN
admet-1272	91	1	in	in	ADP
admet-1272	91	2	a	a	DET
admet-1272	91	3	report	report	NOUN
admet-1272	91	4	in	in	ADP
admet-1272	91	5	acs	acs	PROPN
admet-1272	91	6	infectious	infectious	ADJ
admet-1272	91	7	diseases	disease	NOUN
admet-1272	91	8	[	[	X
admet-1272	91	9	17	17	NUM
admet-1272	91	10	]	]	PUNCT
admet-1272	91	11	.	.	PUNCT
admet-1272	92	1	this	this	DET
admet-1272	92	2	report	report	NOUN
admet-1272	92	3	confirmed	confirm	VERB
admet-1272	92	4	that	that	SCONJ
admet-1272	92	5	,	,	PUNCT
admet-1272	92	6	as	as	SCONJ
admet-1272	92	7	reported	report	VERB
admet-1272	92	8	earlier	early	ADV
admet-1272	92	9	,	,	PUNCT
admet-1272	92	10	this	this	DET
admet-1272	92	11	series	series	NOUN
admet-1272	92	12	of	of	ADP
admet-1272	92	13	molecules	molecule	NOUN
admet-1272	92	14	bind	bind	VERB
admet-1272	92	15	directly	directly	ADV
admet-1272	92	16	to	to	ADP
admet-1272	92	17	the	the	DET
admet-1272	92	18	undecaprenyl	undecaprenyl	ADJ
admet-1272	92	19	pyrophosphate	pyrophosphate	NOUN
admet-1272	92	20	synthases	synthase	NOUN
admet-1272	92	21	(	(	PUNCT
admet-1272	92	22	upps	upps	NOUN
admet-1272	92	23	)	)	PUNCT
admet-1272	92	24	of	of	ADP
admet-1272	92	25	e.	e.	PROPN
admet-1272	92	26	faecalis	faecalis	PROPN
admet-1272	92	27	,	,	PUNCT
admet-1272	92	28	s.	s.	PROPN
admet-1272	92	29	aureus	aureus	PROPN
admet-1272	92	30	and	and	CCONJ
admet-1272	92	31	e.	e.	PROPN
admet-1272	92	32	coli	coli	PROPN
admet-1272	92	33	in	in	ADP
admet-1272	92	34	a	a	DET
admet-1272	92	35	direct	direct	ADJ
admet-1272	92	36	and	and	CCONJ
admet-1272	92	37	highaffinity	highaffinity	NOUN
admet-1272	92	38	manner	manner	NOUN
admet-1272	92	39	.	.	PUNCT
admet-1272	93	1	this	this	DET
admet-1272	93	2	paper	paper	NOUN
admet-1272	93	3	is	be	AUX
admet-1272	93	4	worth	worth	ADJ
admet-1272	93	5	consulting	consult	VERB
admet-1272	93	6	as	as	SCONJ
admet-1272	93	7	the	the	DET
admet-1272	93	8	models	model	NOUN
admet-1272	93	9	can	can	AUX
admet-1272	93	10	be	be	AUX
admet-1272	93	11	used	use	VERB
admet-1272	93	12	for	for	ADP
admet-1272	93	13	further	further	ADJ
admet-1272	93	14	optimization	optimization	NOUN
admet-1272	93	15	of	of	ADP
admet-1272	93	16	these	these	DET
admet-1272	93	17	molecules	molecule	NOUN
admet-1272	93	18	and	and	CCONJ
admet-1272	93	19	analogues	analogue	NOUN
admet-1272	93	20	as	as	ADP
admet-1272	93	21	upps	upps	NOUN
admet-1272	93	22	is	be	AUX
admet-1272	93	23	an	an	DET
admet-1272	93	24	essential	essential	ADJ
admet-1272	93	25	component	component	NOUN
admet-1272	93	26	of	of	ADP
admet-1272	93	27	cell	cell	NOUN
admet-1272	93	28	wall	wall	NOUN
admet-1272	93	29	biosynthesis	biosynthesis	NOUN
admet-1272	93	30	.	.	PUNCT
admet-1272	94	1	since	since	SCONJ
admet-1272	94	2	the	the	DET
admet-1272	94	3	nicolaou	nicolaou	ADJ
admet-1272	94	4	group	group	NOUN
admet-1272	94	5	have	have	AUX
admet-1272	94	6	successfully	successfully	ADV
admet-1272	94	7	synthesized	synthesize	VERB
admet-1272	94	8	these	these	DET
admet-1272	94	9	molecules	molecule	NOUN
admet-1272	94	10	,	,	PUNCT
admet-1272	94	11	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	94	12	a	a	DET
admet-1272	94	13	(	(	PUNCT
admet-1272	94	14	7	7	NUM
admet-1272	94	15	)	)	PUNCT
admet-1272	94	16	and	and	CCONJ
admet-1272	94	17	b	b	PROPN
admet-1272	94	18	(	(	PUNCT
admet-1272	94	19	8)	8)	NUM
admet-1272	94	20	and	and	CCONJ
admet-1272	94	21	the	the	DET
admet-1272	94	22	capon	capon	NOUN
admet-1272	94	23	group	group	NOUN
admet-1272	94	24	have	have	AUX
admet-1272	94	25	shown	show	VERB
admet-1272	94	26	the	the	DET
admet-1272	94	27	simple	simple	ADJ
admet-1272	94	28	difference	difference	NOUN
admet-1272	94	29	in	in	ADP
admet-1272	94	30	c	c	PROPN
admet-1272	94	31	(	(	PUNCT
admet-1272	94	32	9	9	NUM
admet-1272	94	33	)	)	PUNCT
admet-1272	94	34	,	,	PUNCT
admet-1272	94	35	these	these	PRON
admet-1272	94	36	are	be	AUX
admet-1272	94	37	excellent	excellent	ADJ
admet-1272	94	38	candidates	candidate	NOUN
admet-1272	94	39	for	for	ADP
admet-1272	94	40	large	large	ADJ
admet-1272	94	41	scale	scale	NOUN
admet-1272	94	42	production	production	NOUN
admet-1272	94	43	,	,	PUNCT
admet-1272	94	44	synthetically	synthetically	ADV
admet-1272	94	45	or	or	CCONJ
admet-1272	94	46	genomically	genomically	ADV
admet-1272	94	47	via	via	ADP
admet-1272	94	48	modification	modification	NOUN
admet-1272	94	49	of	of	ADP
admet-1272	94	50	the	the	DET
admet-1272	94	51	bgc	bgc	NOUN
admet-1272	94	52	plus	plus	CCONJ
admet-1272	94	53	fermentation	fermentation	NOUN
admet-1272	94	54	,	,	PUNCT
admet-1272	94	55	to	to	PART
admet-1272	94	56	provide	provide	VERB
admet-1272	94	57	another	another	DET
admet-1272	94	58	candidate	candidate	NOUN
admet-1272	94	59	for	for	ADP
admet-1272	94	60	use	use	NOUN
admet-1272	94	61	against	against	ADP
admet-1272	94	62	members	member	NOUN
admet-1272	94	63	of	of	ADP
admet-1272	94	64	the	the	DET
admet-1272	94	65	gram	gram	NOUN
admet-1272	94	66	-	-	PUNCT
admet-1272	94	67	positive	positive	ADJ
admet-1272	94	68	eskape	eskape	NOUN
admet-1272	94	69	series	series	NOUN
admet-1272	94	70	.	.	PUNCT
admet-1272	95	1	the	the	DET
admet-1272	95	2	relevant	relevant	ADJ
admet-1272	95	3	structures	structure	NOUN
admet-1272	95	4	are	be	AUX
admet-1272	95	5	shown	show	VERB
admet-1272	95	6	in	in	ADP
admet-1272	95	7	figure	figure	NOUN
admet-1272	95	8	3	3	NUM
admet-1272	95	9	.	.	PUNCT
admet-1272	95	10	figure	figure	VERB
admet-1272	95	11	3	3	NUM
admet-1272	95	12	.	.	NOUN
admet-1272	95	13	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	95	14	;	;	PUNCT
admet-1272	95	15	structures	structure	NOUN
admet-1272	95	16	7	7	NUM
admet-1272	95	17	to	to	PART
admet-1272	95	18	12	12	NUM
admet-1272	95	19	peptidic	peptidic	ADJ
admet-1272	95	20	candidates	candidate	NOUN
admet-1272	95	21	(	(	PUNCT
admet-1272	95	22	other	other	ADJ
admet-1272	95	23	than	than	ADP
admet-1272	95	24	vancomycin	vancomycin	PROPN
admet-1272	95	25	)	)	PUNCT
admet-1272	96	1	this	this	DET
admet-1272	96	2	section	section	NOUN
admet-1272	96	3	will	will	AUX
admet-1272	96	4	include	include	VERB
admet-1272	96	5	both	both	PRON
admet-1272	96	6	naturally	naturally	ADV
admet-1272	96	7	occurring	occur	VERB
admet-1272	96	8	and	and	CCONJ
admet-1272	96	9	partially	partially	ADV
admet-1272	96	10	synthesized	synthesize	VERB
admet-1272	96	11	molecules	molecule	NOUN
admet-1272	96	12	.	.	PUNCT
admet-1272	97	1	in	in	ADP
admet-1272	97	2	some	some	DET
admet-1272	97	3	cases	case	NOUN
admet-1272	97	4	,	,	PUNCT
admet-1272	97	5	the	the	DET
admet-1272	97	6	molecules	molecule	NOUN
admet-1272	97	7	will	will	AUX
admet-1272	97	8	be	be	AUX
admet-1272	97	9	well	well	ADV
admet-1272	97	10	-	-	PUNCT
admet-1272	97	11	known	know	VERB
admet-1272	97	12	and	and	CCONJ
admet-1272	97	13	not	not	PART
admet-1272	97	14	in	in	ADP
admet-1272	97	15	others	other	NOUN
admet-1272	97	16	.	.	PUNCT
admet-1272	98	1	colistins	colistin	NOUN
admet-1272	98	2	and	and	CCONJ
admet-1272	98	3	polymyxins	polymyxin	VERB
admet-1272	98	4	these	these	DET
admet-1272	98	5	peptidic	peptidic	ADJ
admet-1272	98	6	antibiotics	antibiotic	NOUN
admet-1272	98	7	were	be	AUX
admet-1272	98	8	frequently	frequently	ADV
admet-1272	98	9	the	the	DET
admet-1272	98	10	“	"	PUNCT
admet-1272	98	11	bane	bane	NOUN
admet-1272	98	12	”	"	PUNCT
admet-1272	98	13	of	of	ADP
admet-1272	98	14	microbiologists	microbiologist	NOUN
admet-1272	98	15	and	and	CCONJ
admet-1272	98	16	chemists	chemist	NOUN
admet-1272	98	17	in	in	ADP
admet-1272	98	18	the	the	DET
admet-1272	98	19	1960s	1960	NOUN
admet-1272	98	20	to	to	ADP
admet-1272	98	21	late	late	ADJ
admet-1272	98	22	1970s	1970	NOUN
admet-1272	98	23	when	when	SCONJ
admet-1272	98	24	pharmaceutical	pharmaceutical	ADJ
admet-1272	98	25	companies	company	NOUN
admet-1272	98	26	with	with	ADP
admet-1272	98	27	active	active	ADJ
admet-1272	98	28	antibiotic	antibiotic	ADJ
admet-1272	98	29	search	search	NOUN
admet-1272	98	30	programs	program	NOUN
admet-1272	98	31	based	base	VERB
admet-1272	98	32	on	on	ADP
admet-1272	98	33	microbial	microbial	ADJ
admet-1272	98	34	fermentation	fermentation	NOUN
admet-1272	98	35	were	be	AUX
admet-1272	98	36	in	in	ADP
admet-1272	98	37	vogue	vogue	NOUN
admet-1272	98	38	.	.	PUNCT
admet-1272	99	1	this	this	PRON
admet-1272	99	2	was	be	AUX
admet-1272	99	3	because	because	SCONJ
admet-1272	99	4	these	these	DET
admet-1272	99	5	compounds	compound	NOUN
admet-1272	99	6	and	and	CCONJ
admet-1272	99	7	their	their	PRON
admet-1272	99	8	close	close	ADJ
admet-1272	99	9	chemical	chemical	ADJ
admet-1272	99	10	relatives	relative	NOUN
admet-1272	99	11	,	,	PUNCT
admet-1272	99	12	had	have	VERB
admet-1272	99	13	“	"	PUNCT
admet-1272	99	14	for	for	ADP
admet-1272	99	15	then	then	ADV
admet-1272	99	16	”	"	PUNCT
admet-1272	99	17	significant	significant	ADJ
admet-1272	99	18	toxicities	toxicity	NOUN
admet-1272	99	19	when	when	SCONJ
admet-1272	99	20	compared	compare	VERB
admet-1272	99	21	to	to	ADP
admet-1272	99	22	the	the	DET
admet-1272	99	23	tetracyclines	tetracycline	NOUN
admet-1272	99	24	,	,	PUNCT
admet-1272	99	25	aminoglycosides	aminoglycoside	NOUN
admet-1272	99	26	etc	etc	X
admet-1272	99	27	.	.	X
admet-1272	100	1	they	they	PRON
admet-1272	100	2	were	be	AUX
admet-1272	100	3	usually	usually	ADV
admet-1272	100	4	just	just	ADV
admet-1272	100	5	“	"	PUNCT
admet-1272	100	6	tossed	toss	VERB
admet-1272	100	7	aside	aside	ADV
admet-1272	100	8	”	"	PUNCT
admet-1272	100	9	and	and	CCONJ
admet-1272	100	10	no	no	DET
admet-1272	100	11	further	further	ADJ
admet-1272	100	12	work	work	NOUN
admet-1272	100	13	was	be	AUX
admet-1272	100	14	done	do	VERB
admet-1272	100	15	with	with	ADP
admet-1272	100	16	them	they	PRON
admet-1272	100	17	,	,	PUNCT
admet-1272	100	18	nor	nor	CCONJ
admet-1272	100	19	with	with	ADP
admet-1272	100	20	the	the	DET
admet-1272	100	21	microbe(s	microbe(s	NOUN
admet-1272	100	22	)	)	PUNCT
admet-1272	100	23	producing	produce	VERB
admet-1272	100	24	them	they	PRON
admet-1272	100	25	.	.	PUNCT
admet-1272	101	1	admet	admet	PROPN
admet-1272	101	2	&	&	CCONJ
admet-1272	101	3	dmpk	dmpk	PROPN
admet-1272	101	4	10(2	10(2	NUM
admet-1272	101	5	)	)	PUNCT
admet-1272	101	6	(	(	PUNCT
admet-1272	101	7	2022	2022	NUM
admet-1272	101	8	)	)	PUNCT
admet-1272	101	9	131	131	NUM
admet-1272	101	10	-	-	SYM
admet-1272	101	11	146	146	NUM
admet-1272	101	12	chemical	chemical	NOUN
admet-1272	101	13	syntheses	synthesis	NOUN
admet-1272	101	14	and	and	CCONJ
admet-1272	101	15	resistant	resistant	ADJ
admet-1272	101	16	antibiotics	antibiotic	NOUN
admet-1272	101	17	doi	doi	NOUN
admet-1272	101	18	:	:	PUNCT
admet-1272	101	19	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	X
admet-1272	101	20	137	137	NUM
admet-1272	101	21	with	with	ADP
admet-1272	101	22	the	the	DET
admet-1272	101	23	current	current	ADJ
admet-1272	101	24	advent	advent	NOUN
admet-1272	101	25	of	of	ADP
admet-1272	101	26	multiple	multiple	ADJ
admet-1272	101	27	resistant	resistant	ADJ
admet-1272	101	28	microbes	microbe	NOUN
admet-1272	101	29	,	,	PUNCT
admet-1272	101	30	combination	combination	NOUN
admet-1272	101	31	therapy	therapy	NOUN
admet-1272	101	32	including	include	VERB
admet-1272	101	33	these	these	DET
admet-1272	101	34	agents	agent	NOUN
admet-1272	101	35	has	have	AUX
admet-1272	101	36	been	be	AUX
admet-1272	101	37	utilized	utilize	VERB
admet-1272	101	38	,	,	PUNCT
admet-1272	101	39	using	use	VERB
admet-1272	101	40	both	both	DET
admet-1272	101	41	polymyxins	polymyxin	NOUN
admet-1272	101	42	and	and	CCONJ
admet-1272	101	43	colistin	colistin	NOUN
admet-1272	101	44	(	(	PUNCT
admet-1272	101	45	aka	aka	ADV
admet-1272	101	46	polymyxin	polymyxin	ADJ
admet-1272	101	47	e	e	NOUN
admet-1272	101	48	)	)	PUNCT
admet-1272	101	49	.	.	PUNCT
admet-1272	102	1	however	however	ADV
admet-1272	102	2	,	,	PUNCT
admet-1272	102	3	in	in	ADP
admet-1272	102	4	2016	2016	NUM
admet-1272	102	5	,	,	PUNCT
admet-1272	102	6	a	a	DET
admet-1272	102	7	report	report	NOUN
admet-1272	102	8	was	be	AUX
admet-1272	102	9	published	publish	VERB
admet-1272	102	10	[	[	PUNCT
admet-1272	102	11	18	18	NUM
admet-1272	102	12	]	]	PUNCT
admet-1272	102	13	giving	give	VERB
admet-1272	102	14	details	detail	NOUN
admet-1272	102	15	of	of	ADP
admet-1272	102	16	a	a	DET
admet-1272	102	17	transmissible	transmissible	ADJ
admet-1272	102	18	plasmid	plasmid	NOUN
admet-1272	102	19	expressing	express	VERB
admet-1272	102	20	the	the	DET
admet-1272	102	21	mcr	mcr	PROPN
admet-1272	102	22	gene	gene	NOUN
admet-1272	102	23	.	.	PUNCT
admet-1272	103	1	this	this	DET
admet-1272	103	2	gene	gene	NOUN
admet-1272	103	3	encoded	encode	VERB
admet-1272	103	4	the	the	DET
admet-1272	103	5	phosphoethanolamine	phosphoethanolamine	NOUN
admet-1272	103	6	transferases	transferase	NOUN
admet-1272	103	7	(	(	PUNCT
admet-1272	103	8	petn	petn	NOUN
admet-1272	103	9	)	)	PUNCT
admet-1272	103	10	that	that	PRON
admet-1272	103	11	catalyzed	catalyze	VERB
admet-1272	103	12	the	the	DET
admet-1272	103	13	addition	addition	NOUN
admet-1272	103	14	of	of	ADP
admet-1272	103	15	a	a	DET
admet-1272	103	16	phosphoethanolamine	phosphoethanolamine	NOUN
admet-1272	103	17	moiety	moiety	NOUN
admet-1272	103	18	to	to	PART
admet-1272	103	19	lipid	lipid	VERB
admet-1272	103	20	a	a	PRON
admet-1272	103	21	in	in	ADP
admet-1272	103	22	the	the	DET
admet-1272	103	23	outer	outer	ADJ
admet-1272	103	24	membrane	membrane	NOUN
admet-1272	103	25	of	of	ADP
admet-1272	103	26	gram	gram	NOUN
admet-1272	103	27	-	-	PUNCT
admet-1272	103	28	negative	negative	ADJ
admet-1272	103	29	bacteria	bacteria	NOUN
admet-1272	103	30	,	,	PUNCT
admet-1272	103	31	thus	thus	ADV
admet-1272	103	32	generating	generate	VERB
admet-1272	103	33	resistance	resistance	NOUN
admet-1272	103	34	to	to	ADP
admet-1272	103	35	the	the	DET
admet-1272	103	36	antibiotics	antibiotic	NOUN
admet-1272	103	37	in	in	ADP
admet-1272	103	38	current	current	ADJ
admet-1272	103	39	use	use	NOUN
admet-1272	103	40	,	,	PUNCT
admet-1272	103	41	including	include	VERB
admet-1272	103	42	these	these	DET
admet-1272	103	43	peptidic	peptidic	ADJ
admet-1272	103	44	agents	agent	NOUN
admet-1272	103	45	.	.	PUNCT
admet-1272	104	1	a	a	DET
admet-1272	104	2	major	major	ADJ
admet-1272	104	3	problem	problem	NOUN
admet-1272	104	4	with	with	ADP
admet-1272	104	5	the	the	DET
admet-1272	104	6	bacteria	bacteria	NOUN
admet-1272	104	7	that	that	PRON
admet-1272	104	8	contain	contain	VERB
admet-1272	104	9	this	this	DET
admet-1272	104	10	plasmid	plasmid	NOUN
admet-1272	104	11	(	(	PUNCT
admet-1272	104	12	or	or	CCONJ
admet-1272	104	13	close	close	ADJ
admet-1272	104	14	variants	variant	NOUN
admet-1272	104	15	)	)	PUNCT
admet-1272	104	16	is	be	AUX
admet-1272	104	17	that	that	SCONJ
admet-1272	104	18	they	they	PRON
admet-1272	104	19	are	be	AUX
admet-1272	104	20	easily	easily	ADV
admet-1272	104	21	transmissible	transmissible	ADJ
admet-1272	104	22	as	as	ADP
admet-1272	104	23	“	"	PUNCT
admet-1272	104	24	water	water	NOUN
admet-1272	104	25	-	-	PUNCT
admet-1272	104	26	borne	bear	VERB
admet-1272	104	27	”	"	PUNCT
admet-1272	104	28	microbes	microbe	NOUN
admet-1272	104	29	,	,	PUNCT
admet-1272	104	30	and	and	CCONJ
admet-1272	104	31	thus	thus	ADV
admet-1272	104	32	have	have	AUX
admet-1272	104	33	spread	spread	VERB
admet-1272	104	34	from	from	ADP
admet-1272	104	35	their	their	PRON
admet-1272	104	36	original	original	ADJ
admet-1272	104	37	source	source	NOUN
admet-1272	104	38	in	in	ADP
admet-1272	104	39	mainland	mainland	NOUN
admet-1272	104	40	china	china	PROPN
admet-1272	104	41	,	,	PUNCT
admet-1272	104	42	to	to	PART
admet-1272	104	43	become	become	VERB
admet-1272	104	44	significant	significant	ADJ
admet-1272	104	45	problems	problem	NOUN
admet-1272	104	46	in	in	ADP
admet-1272	104	47	multiple	multiple	ADJ
admet-1272	104	48	areas	area	NOUN
admet-1272	104	49	,	,	PUNCT
admet-1272	104	50	as	as	SCONJ
admet-1272	104	51	shown	show	VERB
admet-1272	104	52	by	by	ADP
admet-1272	104	53	the	the	DET
admet-1272	104	54	2021	2021	NUM
admet-1272	104	55	paper	paper	NOUN
admet-1272	104	56	by	by	ADP
admet-1272	104	57	cherak	cherak	NOUN
admet-1272	104	58	et	et	NOUN
admet-1272	104	59	al	al	PROPN
admet-1272	105	1	[	[	X
admet-1272	105	2	19	19	NUM
admet-1272	105	3	]	]	PUNCT
admet-1272	105	4	.	.	PUNCT
admet-1272	106	1	in	in	ADP
admet-1272	106	2	an	an	DET
admet-1272	106	3	effort	effort	NOUN
admet-1272	106	4	to	to	PART
admet-1272	106	5	produce	produce	VERB
admet-1272	106	6	new	new	ADJ
admet-1272	106	7	variations	variation	NOUN
admet-1272	106	8	on	on	ADP
admet-1272	106	9	the	the	DET
admet-1272	106	10	old	old	ADJ
admet-1272	106	11	and	and	CCONJ
admet-1272	106	12	well	well	ADV
admet-1272	106	13	used	used	ADJ
admet-1272	106	14	/	/	SYM
admet-1272	106	15	known	know	VERB
admet-1272	106	16	polymyxin	polymyxin	PROPN
admet-1272	106	17	b	b	PROPN
admet-1272	106	18	and	and	CCONJ
admet-1272	106	19	colistin	colistin	PROPN
admet-1272	106	20	,	,	PUNCT
admet-1272	106	21	a	a	DET
admet-1272	106	22	group	group	NOUN
admet-1272	106	23	of	of	ADP
admet-1272	106	24	researchers	researcher	NOUN
admet-1272	106	25	from	from	ADP
admet-1272	106	26	china	china	PROPN
admet-1272	106	27	,	,	PUNCT
admet-1272	106	28	south	south	PROPN
admet-1272	106	29	australia	australia	PROPN
admet-1272	106	30	and	and	CCONJ
admet-1272	106	31	germany	germany	PROPN
admet-1272	106	32	recently	recently	ADV
admet-1272	106	33	(	(	PUNCT
admet-1272	106	34	2021	2021	NUM
admet-1272	106	35	)	)	PUNCT
admet-1272	106	36	published	publish	VERB
admet-1272	106	37	the	the	DET
admet-1272	106	38	results	result	NOUN
admet-1272	106	39	of	of	ADP
admet-1272	106	40	a	a	DET
admet-1272	106	41	largescale	largescale	NOUN
admet-1272	106	42	program	program	NOUN
admet-1272	106	43	to	to	PART
admet-1272	106	44	discover	discover	VERB
admet-1272	106	45	potential	potential	ADJ
admet-1272	106	46	agents	agent	NOUN
admet-1272	106	47	against	against	ADP
admet-1272	106	48	resistant	resistant	ADJ
admet-1272	106	49	a.	a.	NOUN
admet-1272	106	50	baumannii	baumannii	NOUN
admet-1272	107	1	[	[	X
admet-1272	107	2	20	20	NUM
admet-1272	107	3	]	]	PUNCT
admet-1272	107	4	.	.	PUNCT
admet-1272	108	1	at	at	ADP
admet-1272	108	2	the	the	DET
admet-1272	108	3	time	time	NOUN
admet-1272	108	4	of	of	ADP
admet-1272	108	5	writing	writing	NOUN
admet-1272	108	6	of	of	ADP
admet-1272	108	7	that	that	DET
admet-1272	108	8	paper	paper	NOUN
admet-1272	108	9	over	over	ADP
admet-1272	108	10	2000	2000	NUM
admet-1272	108	11	polymyxin	polymyxin	NOUN
admet-1272	108	12	analogues	analogue	NOUN
admet-1272	108	13	had	have	AUX
admet-1272	108	14	been	be	AUX
admet-1272	108	15	reported	report	VERB
admet-1272	108	16	in	in	ADP
admet-1272	108	17	the	the	DET
admet-1272	108	18	literature	literature	NOUN
admet-1272	108	19	,	,	PUNCT
admet-1272	108	20	with	with	ADP
admet-1272	108	21	some	some	DET
admet-1272	108	22	early	early	ADJ
admet-1272	108	23	and	and	CCONJ
admet-1272	108	24	some	some	DET
admet-1272	108	25	more	more	ADV
admet-1272	108	26	recent	recent	ADJ
admet-1272	108	27	examples	example	NOUN
admet-1272	108	28	also	also	ADV
admet-1272	108	29	reported	report	VERB
admet-1272	108	30	by	by	ADP
admet-1272	108	31	vaara	vaara	NOUN
admet-1272	108	32	in	in	ADP
admet-1272	108	33	2019	2019	NUM
admet-1272	109	1	[	[	X
admet-1272	109	2	21	21	NUM
admet-1272	109	3	]	]	PUNCT
admet-1272	109	4	.	.	PUNCT
admet-1272	110	1	of	of	ADP
admet-1272	110	2	the	the	DET
admet-1272	110	3	2000	2000	NUM
admet-1272	110	4	plus	plus	CCONJ
admet-1272	110	5	variations	variation	NOUN
admet-1272	110	6	referred	refer	VERB
admet-1272	110	7	to	to	ADP
admet-1272	110	8	earlier	early	ADV
admet-1272	110	9	,	,	PUNCT
admet-1272	110	10	only	only	ADV
admet-1272	110	11	3	3	NUM
admet-1272	110	12	demonstrated	demonstrate	VERB
admet-1272	110	13	improved	improved	ADJ
admet-1272	110	14	activities	activity	NOUN
admet-1272	110	15	against	against	ADP
admet-1272	110	16	gram	gram	NOUN
admet-1272	110	17	-	-	PUNCT
admet-1272	110	18	negative	negative	ADJ
admet-1272	110	19	pathogens	pathogen	NOUN
admet-1272	110	20	.	.	PUNCT
admet-1272	111	1	using	use	VERB
admet-1272	111	2	clever	clever	ADJ
admet-1272	111	3	chemistry	chemistry	NOUN
admet-1272	111	4	and	and	CCONJ
admet-1272	111	5	sequential	sequential	ADJ
admet-1272	111	6	alanine	alanine	NOUN
admet-1272	111	7	substitution	substitution	NOUN
admet-1272	111	8	,	,	PUNCT
admet-1272	112	1	jiang	jiang	PROPN
admet-1272	112	2	et	et	PROPN
admet-1272	112	3	al	al	PROPN
admet-1272	113	1	[	[	X
admet-1272	113	2	20	20	NUM
admet-1272	113	3	]	]	PUNCT
admet-1272	113	4	derived	derive	VERB
admet-1272	113	5	a	a	DET
admet-1272	113	6	potent	potent	ADJ
admet-1272	113	7	and	and	CCONJ
admet-1272	113	8	novel	novel	ADJ
admet-1272	113	9	polymyxin	polymyxin	ADJ
admet-1272	113	10	analogue	analogue	NOUN
admet-1272	113	11	,	,	PUNCT
admet-1272	113	12	faddi-287	faddi-287	NOUN
admet-1272	113	13	(	(	PUNCT
admet-1272	113	14	13	13	NUM
admet-1272	113	15	)	)	PUNCT
admet-1272	113	16	that	that	PRON
admet-1272	113	17	folded	fold	VERB
admet-1272	113	18	similarly	similarly	ADV
admet-1272	113	19	to	to	ADP
admet-1272	113	20	pmb3	pmb3	PROPN
admet-1272	113	21	(	(	PUNCT
admet-1272	113	22	14	14	NUM
admet-1272	113	23	)	)	PUNCT
admet-1272	113	24	and	and	CCONJ
admet-1272	113	25	demonstrated	demonstrate	VERB
admet-1272	113	26	mics	mic	NOUN
admet-1272	113	27	of	of	ADP
admet-1272	113	28	0.125	0.125	NUM
admet-1272	113	29	-	-	SYM
admet-1272	113	30	0.5	0.5	NUM
admet-1272	113	31	µg	µg	NOUN
admet-1272	113	32	ml-1	ml-1	ADV
admet-1272	113	33	against	against	ADP
admet-1272	113	34	a.	a.	NOUN
admet-1272	113	35	baumannii	baumannii	PROPN
admet-1272	113	36	compared	compare	VERB
admet-1272	113	37	to	to	ADP
admet-1272	113	38	polymyxin	polymyxin	PROPN
admet-1272	113	39	b.	b.	PROPN
admet-1272	113	40	faddi-287	faddi-287	PROPN
admet-1272	113	41	is	be	AUX
admet-1272	113	42	covered	cover	VERB
admet-1272	113	43	by	by	ADP
admet-1272	113	44	the	the	DET
admet-1272	113	45	patent	patent	NOUN
admet-1272	113	46	wo2015149131	wo2015149131	PROPN
admet-1272	113	47	which	which	PRON
admet-1272	113	48	has	have	AUX
admet-1272	113	49	also	also	ADV
admet-1272	113	50	been	be	AUX
admet-1272	113	51	granted	grant	VERB
admet-1272	113	52	in	in	ADP
admet-1272	113	53	the	the	DET
admet-1272	113	54	usa	usa	PROPN
admet-1272	113	55	and	and	CCONJ
admet-1272	113	56	china	china	PROPN
admet-1272	113	57	.	.	PUNCT
admet-1272	114	1	very	very	ADV
admet-1272	114	2	recently	recently	ADV
admet-1272	114	3	,	,	PUNCT
admet-1272	114	4	the	the	DET
admet-1272	114	5	brady	brady	PROPN
admet-1272	114	6	group	group	PROPN
admet-1272	114	7	presented	present	VERB
admet-1272	114	8	details	detail	NOUN
admet-1272	114	9	on	on	ADP
admet-1272	114	10	a	a	DET
admet-1272	114	11	semisynthetic	semisynthetic	ADJ
admet-1272	114	12	,	,	PUNCT
admet-1272	114	13	optimized	optimize	VERB
admet-1272	114	14	amp	amp	NOUN
admet-1272	114	15	based	base	VERB
admet-1272	114	16	upon	upon	SCONJ
admet-1272	114	17	a	a	DET
admet-1272	114	18	genomic	genomic	ADJ
admet-1272	114	19	analysis	analysis	NOUN
admet-1272	114	20	of	of	ADP
admet-1272	114	21	sequences	sequence	NOUN
admet-1272	114	22	in	in	ADP
admet-1272	114	23	bacteria	bacteria	NOUN
admet-1272	114	24	that	that	PRON
admet-1272	114	25	might	might	AUX
admet-1272	114	26	well	well	ADV
admet-1272	114	27	produce	produce	VERB
admet-1272	114	28	agents	agent	NOUN
admet-1272	114	29	that	that	PRON
admet-1272	114	30	are	be	AUX
admet-1272	114	31	analogues	analogue	NOUN
admet-1272	114	32	of	of	ADP
admet-1272	114	33	colistin	colistin	NOUN
admet-1272	114	34	(	(	PUNCT
admet-1272	114	35	15	15	NUM
admet-1272	114	36	)	)	PUNCT
admet-1272	114	37	.	.	PUNCT
admet-1272	115	1	they	they	PRON
admet-1272	115	2	reported	report	VERB
admet-1272	115	3	the	the	DET
admet-1272	115	4	modified	modify	VERB
admet-1272	115	5	colistin	colistin	NOUN
admet-1272	115	6	known	know	VERB
admet-1272	115	7	as	as	ADP
admet-1272	115	8	biphenyl	biphenyl	NOUN
admet-1272	115	9	macolacin	macolacin	NOUN
admet-1272	115	10	(	(	PUNCT
admet-1272	115	11	16	16	NUM
admet-1272	115	12	)	)	PUNCT
admet-1272	115	13	in	in	ADP
admet-1272	115	14	nature	nature	NOUN
admet-1272	115	15	in	in	ADP
admet-1272	115	16	early	early	ADJ
admet-1272	115	17	2022	2022	NUM
admet-1272	116	1	[	[	X
admet-1272	116	2	22	22	NUM
admet-1272	116	3	]	]	PUNCT
admet-1272	116	4	.	.	PUNCT
admet-1272	117	1	interestingly	interestingly	ADV
admet-1272	117	2	a	a	DET
admet-1272	117	3	major	major	ADJ
admet-1272	117	4	substitution	substitution	NOUN
admet-1272	117	5	was	be	AUX
admet-1272	117	6	the	the	DET
admet-1272	117	7	biphenyl	biphenyl	NOUN
admet-1272	117	8	group	group	NOUN
admet-1272	117	9	,	,	PUNCT
admet-1272	117	10	one	one	NUM
admet-1272	117	11	that	that	PRON
admet-1272	117	12	boger	boger	NOUN
admet-1272	117	13	used	use	VERB
admet-1272	117	14	in	in	ADP
admet-1272	117	15	his	his	PRON
admet-1272	117	16	successful	successful	ADJ
admet-1272	117	17	synthesis	synthesis	NOUN
admet-1272	117	18	of	of	ADP
admet-1272	117	19	the	the	DET
admet-1272	117	20	highly	highly	ADV
admet-1272	117	21	bioactive	bioactive	ADJ
admet-1272	117	22	maxamycins	maxamycin	NOUN
admet-1272	117	23	.	.	PUNCT
admet-1272	118	1	vancomyxins	vancomyxin	NOUN
admet-1272	118	2	although	although	SCONJ
admet-1272	118	3	this	this	DET
admet-1272	118	4	discussion	discussion	NOUN
admet-1272	118	5	could	could	AUX
admet-1272	118	6	fit	fit	VERB
admet-1272	118	7	under	under	ADP
admet-1272	118	8	the	the	DET
admet-1272	118	9	discussion	discussion	NOUN
admet-1272	118	10	of	of	ADP
admet-1272	118	11	vancomycin	vancomycin	PROPN
admet-1272	118	12	modifications	modification	NOUN
admet-1272	118	13	above	above	ADV
admet-1272	118	14	,	,	PUNCT
admet-1272	118	15	because	because	SCONJ
admet-1272	118	16	it	it	PRON
admet-1272	118	17	now	now	ADV
admet-1272	118	18	extends	extend	VERB
admet-1272	118	19	the	the	DET
admet-1272	118	20	activity	activity	NOUN
admet-1272	118	21	of	of	ADP
admet-1272	118	22	vancomycin	vancomycin	PROPN
admet-1272	118	23	analogues	analogue	NOUN
admet-1272	118	24	into	into	ADP
admet-1272	118	25	gram	gram	NOUN
admet-1272	118	26	-	-	PUNCT
admet-1272	118	27	negative	negative	ADJ
admet-1272	118	28	space	space	NOUN
admet-1272	118	29	,	,	PUNCT
admet-1272	118	30	and	and	CCONJ
admet-1272	118	31	does	do	AUX
admet-1272	118	32	not	not	PART
admet-1272	118	33	come	come	VERB
admet-1272	118	34	from	from	ADP
admet-1272	118	35	the	the	DET
admet-1272	118	36	boger	boger	PROPN
admet-1272	118	37	group	group	NOUN
admet-1272	118	38	,	,	PUNCT
admet-1272	118	39	it	it	PRON
admet-1272	118	40	is	be	AUX
admet-1272	118	41	probably	probably	ADV
admet-1272	118	42	a	a	DET
admet-1272	118	43	better	well	ADJ
admet-1272	118	44	fit	fit	NOUN
admet-1272	118	45	in	in	ADP
admet-1272	118	46	this	this	DET
admet-1272	118	47	section	section	NOUN
admet-1272	118	48	.	.	PUNCT
admet-1272	119	1	although	although	SCONJ
admet-1272	119	2	vancomycin	vancomycin	PROPN
admet-1272	119	3	by	by	ADP
admet-1272	119	4	itself	itself	PRON
admet-1272	119	5	(	(	PUNCT
admet-1272	119	6	as	as	SCONJ
admet-1272	119	7	described	describe	VERB
admet-1272	119	8	earlier	early	ADV
admet-1272	119	9	)	)	PUNCT
admet-1272	119	10	is	be	AUX
admet-1272	119	11	effectively	effectively	ADV
admet-1272	119	12	inactive	inactive	ADJ
admet-1272	119	13	against	against	ADP
admet-1272	119	14	gram	gram	NOUN
admet-1272	119	15	-	-	PUNCT
admet-1272	119	16	negative	negative	ADJ
admet-1272	119	17	bacteria	bacteria	NOUN
admet-1272	119	18	,	,	PUNCT
admet-1272	119	19	it	it	PRON
admet-1272	119	20	will	will	AUX
admet-1272	119	21	bind	bind	VERB
admet-1272	119	22	to	to	ADP
admet-1272	119	23	the	the	DET
admet-1272	119	24	lipid	lipid	PROPN
admet-1272	119	25	ii	ii	PROPN
admet-1272	119	26	component	component	NOUN
admet-1272	119	27	in	in	ADP
admet-1272	119	28	gram	gram	NOUN
admet-1272	119	29	-	-	PUNCT
admet-1272	119	30	negative	negative	ADJ
admet-1272	119	31	bacteria	bacteria	NOUN
admet-1272	119	32	if	if	SCONJ
admet-1272	119	33	the	the	DET
admet-1272	119	34	outer	outer	ADJ
admet-1272	119	35	membrane	membrane	NOUN
admet-1272	119	36	is	be	AUX
admet-1272	119	37	“	"	PUNCT
admet-1272	119	38	made	make	VERB
admet-1272	119	39	permeable	permeable	ADJ
admet-1272	119	40	.	.	PUNCT
admet-1272	119	41	”	"	PUNCT
admet-1272	120	1	it	it	PRON
admet-1272	120	2	has	have	AUX
admet-1272	120	3	been	be	AUX
admet-1272	120	4	known	know	VERB
admet-1272	120	5	since	since	SCONJ
admet-1272	120	6	1989	1989	NUM
admet-1272	120	7	that	that	DET
admet-1272	120	8	coadministration	coadministration	NOUN
admet-1272	120	9	of	of	ADP
admet-1272	120	10	suitable	suitable	ADJ
admet-1272	120	11	“	"	PUNCT
admet-1272	120	12	penetrating	penetrate	VERB
admet-1272	120	13	”	"	PUNCT
admet-1272	120	14	agents	agent	NOUN
admet-1272	120	15	with	with	ADP
admet-1272	120	16	vancomycin	vancomycin	PROPN
admet-1272	120	17	will	will	AUX
admet-1272	120	18	synergize	synergize	VERB
admet-1272	120	19	the	the	DET
admet-1272	120	20	effects	effect	NOUN
admet-1272	120	21	of	of	ADP
admet-1272	120	22	vancomycin	vancomycin	PROPN
admet-1272	120	23	against	against	ADP
admet-1272	120	24	the	the	DET
admet-1272	120	25	gram	gram	NOUN
admet-1272	120	26	-	-	PUNCT
admet-1272	120	27	negative	negative	ADJ
admet-1272	120	28	bacterium	bacterium	NOUN
admet-1272	120	29	e.	e.	PROPN
admet-1272	120	30	coli	coli	PROPN
admet-1272	121	1	[	[	X
admet-1272	121	2	23	23	NUM
admet-1272	121	3	]	]	PUNCT
admet-1272	121	4	.	.	PUNCT
admet-1272	122	1	then	then	ADV
admet-1272	122	2	in	in	ADP
admet-1272	122	3	2010	2010	NUM
admet-1272	122	4	,	,	PUNCT
admet-1272	122	5	gordon	gordon	PROPN
admet-1272	122	6	et	et	PROPN
admet-1272	122	7	al	al	PROPN
admet-1272	122	8	demonstrated	demonstrate	VERB
admet-1272	122	9	significant	significant	ADJ
admet-1272	122	10	activity	activity	NOUN
admet-1272	122	11	of	of	ADP
admet-1272	122	12	a	a	DET
admet-1272	122	13	vancomycin	vancomycin	PROPN
admet-1272	122	14	-	-	PUNCT
admet-1272	122	15	colistin	colistin	NOUN
admet-1272	122	16	physical	physical	ADJ
admet-1272	122	17	combination	combination	NOUN
admet-1272	122	18	(	(	PUNCT
admet-1272	122	19	i.e.co	i.e.co	NOUN
admet-1272	122	20	-	-	NOUN
admet-1272	122	21	administration	administration	NOUN
admet-1272	122	22	of	of	ADP
admet-1272	122	23	the	the	DET
admet-1272	122	24	two	two	NUM
admet-1272	122	25	antibiotics	antibiotic	NOUN
admet-1272	122	26	)	)	PUNCT
admet-1272	123	1	[	[	X
admet-1272	123	2	24	24	NUM
admet-1272	123	3	]	]	PUNCT
admet-1272	123	4	.	.	PUNCT
admet-1272	124	1	moving	move	VERB
admet-1272	124	2	to	to	ADP
admet-1272	124	3	2021	2021	NUM
admet-1272	124	4	,	,	PUNCT
admet-1272	124	5	van	van	PROPN
admet-1272	124	6	groesen	groesen	PROPN
admet-1272	124	7	et	et	PROPN
admet-1272	124	8	al	al	PROPN
admet-1272	124	9	came	come	VERB
admet-1272	124	10	up	up	ADP
admet-1272	124	11	with	with	ADP
admet-1272	124	12	what	what	PRON
admet-1272	124	13	they	they	PRON
admet-1272	124	14	are	be	AUX
admet-1272	124	15	calling	call	VERB
admet-1272	124	16	“	"	PUNCT
admet-1272	124	17	vancomyxins	vancomyxin	NOUN
admet-1272	124	18	,	,	PUNCT
admet-1272	124	19	”	"	PUNCT
admet-1272	124	20	where	where	SCONJ
admet-1272	124	21	a	a	DET
admet-1272	124	22	short	short	ADJ
admet-1272	124	23	spacer	spacer	NOUN
admet-1272	124	24	was	be	AUX
admet-1272	124	25	inserted	insert	VERB
admet-1272	124	26	between	between	ADP
admet-1272	124	27	vancomycin	vancomycin	PROPN
admet-1272	124	28	and	and	CCONJ
admet-1272	124	29	what	what	PRON
admet-1272	124	30	they	they	PRON
admet-1272	124	31	called	call	VERB
admet-1272	124	32	the	the	DET
admet-1272	124	33	“	"	PUNCT
admet-1272	124	34	polymyxin	polymyxin	ADJ
admet-1272	124	35	e	e	NOUN
admet-1272	124	36	nonapeptide	nonapeptide	ADJ
admet-1272	124	37	pmen	pman	NOUN
admet-1272	124	38	(	(	PUNCT
admet-1272	124	39	17	17	NUM
admet-1272	124	40	)	)	PUNCT
admet-1272	124	41	.	.	PUNCT
admet-1272	124	42	”	"	PUNCT
admet-1272	125	1	depending	depend	VERB
admet-1272	125	2	upon	upon	SCONJ
admet-1272	125	3	the	the	DET
admet-1272	125	4	specific	specific	ADJ
admet-1272	125	5	combination	combination	NOUN
admet-1272	125	6	of	of	ADP
admet-1272	125	7	these	these	DET
admet-1272	125	8	molecules	molecule	NOUN
admet-1272	125	9	,	,	PUNCT
admet-1272	125	10	they	they	PRON
admet-1272	125	11	could	could	AUX
admet-1272	125	12	be	be	AUX
admet-1272	125	13	linked	link	VERB
admet-1272	125	14	via	via	ADP
admet-1272	125	15	the	the	DET
admet-1272	125	16	c	c	NOUN
admet-1272	125	17	-	-	PUNCT
admet-1272	125	18	terminus	terminus	NOUN
admet-1272	125	19	of	of	ADP
admet-1272	125	20	vancomycin	vancomycin	PROPN
admet-1272	125	21	,	,	PUNCT
admet-1272	125	22	or	or	CCONJ
admet-1272	125	23	in	in	ADP
admet-1272	125	24	other	other	ADJ
admet-1272	125	25	examples	example	NOUN
admet-1272	125	26	,	,	PUNCT
admet-1272	125	27	linked	link	VERB
admet-1272	125	28	to	to	ADP
admet-1272	125	29	the	the	DET
admet-1272	125	30	vancosamine	vancosamine	ADJ
admet-1272	125	31	amino	amino	NOUN
admet-1272	125	32	group	group	NOUN
admet-1272	125	33	via	via	ADP
admet-1272	125	34	a	a	DET
admet-1272	125	35	slightly	slightly	ADV
admet-1272	125	36	more	more	ADV
admet-1272	125	37	complex	complex	ADJ
admet-1272	125	38	method	method	NOUN
admet-1272	125	39	involving	involve	VERB
admet-1272	125	40	a	a	DET
admet-1272	125	41	triazole	triazole	ADJ
admet-1272	125	42	linker	linker	NOUN
admet-1272	125	43	,	,	PUNCT
admet-1272	125	44	giving	give	VERB
admet-1272	125	45	rise	rise	NOUN
admet-1272	125	46	to	to	ADP
admet-1272	125	47	a	a	DET
admet-1272	125	48	series	series	NOUN
admet-1272	125	49	of	of	ADP
admet-1272	125	50	compounds	compound	NOUN
admet-1272	125	51	[	[	X
admet-1272	125	52	25	25	NUM
admet-1272	125	53	]	]	PUNCT
admet-1272	125	54	.	.	PUNCT
admet-1272	126	1	their	their	PRON
admet-1272	126	2	structures	structure	NOUN
admet-1272	126	3	are	be	AUX
admet-1272	126	4	not	not	PART
admet-1272	126	5	given	give	VERB
admet-1272	126	6	due	due	ADP
admet-1272	126	7	to	to	ADP
admet-1272	126	8	their	their	PRON
admet-1272	126	9	complexity	complexity	NOUN
admet-1272	126	10	/	/	SYM
admet-1272	126	11	sizes	size	NOUN
admet-1272	126	12	,	,	PUNCT
admet-1272	126	13	but	but	CCONJ
admet-1272	126	14	the	the	DET
admet-1272	126	15	combinations	combination	NOUN
admet-1272	126	16	were	be	AUX
admet-1272	126	17	evaluated	evaluate	VERB
admet-1272	126	18	against	against	ADP
admet-1272	126	19	four	four	NUM
admet-1272	126	20	gram	gram	NOUN
admet-1272	126	21	-	-	PUNCT
admet-1272	126	22	negative	negative	ADJ
admet-1272	126	23	and	and	CCONJ
admet-1272	126	24	five	five	NUM
admet-1272	126	25	gram	gram	ADJ
admet-1272	126	26	-	-	PUNCT
admet-1272	126	27	positive	positive	ADJ
admet-1272	126	28	bacteria	bacteria	NOUN
admet-1272	126	29	with	with	ADP
admet-1272	126	30	vancomycin	vancomycin	PROPN
admet-1272	126	31	and	and	CCONJ
admet-1272	126	32	pmen	pman	NOUN
admet-1272	126	33	separately	separately	ADV
admet-1272	126	34	,	,	PUNCT
admet-1272	126	35	and	and	CCONJ
admet-1272	126	36	then	then	ADV
admet-1272	126	37	vancomycin	vancomycin	PROPN
admet-1272	126	38	plus	plus	CCONJ
admet-1272	126	39	a	a	DET
admet-1272	126	40	constant	constant	ADJ
admet-1272	126	41	8	8	NUM
admet-1272	126	42	µg	µg	NOUN
admet-1272	126	43	ml-1	ml-1	PRON
admet-1272	126	44	of	of	ADP
admet-1272	126	45	pmen	pman	NOUN
admet-1272	126	46	versus	versus	ADP
admet-1272	126	47	six	six	NUM
admet-1272	126	48	of	of	ADP
admet-1272	126	49	the	the	DET
admet-1272	126	50	vancomyxins	vancomyxin	NOUN
admet-1272	126	51	.	.	PUNCT
admet-1272	127	1	in	in	ADP
admet-1272	127	2	most	most	ADJ
admet-1272	127	3	cases	case	NOUN
admet-1272	127	4	,	,	PUNCT
admet-1272	127	5	one	one	NUM
admet-1272	127	6	or	or	CCONJ
admet-1272	127	7	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	NOUN
admet-1272	127	8	david	david	PROPN
admet-1272	127	9	j.	j.	PROPN
admet-1272	127	10	newman	newman	PROPN
admet-1272	127	11	admet	admet	PROPN
admet-1272	127	12	&	&	CCONJ
admet-1272	127	13	dmpk	dmpk	PROPN
admet-1272	127	14	10(2	10(2	NUM
admet-1272	127	15	)	)	PUNCT
admet-1272	127	16	(	(	PUNCT
admet-1272	127	17	2022	2022	NUM
admet-1272	127	18	)	)	PUNCT
admet-1272	127	19	131	131	NUM
admet-1272	127	20	-	-	SYM
admet-1272	127	21	146	146	NUM
admet-1272	127	22	138	138	NUM
admet-1272	127	23	more	more	ADJ
admet-1272	127	24	of	of	ADP
admet-1272	127	25	the	the	DET
admet-1272	127	26	vancomyxins	vancomyxin	NOUN
admet-1272	127	27	demonstrated	demonstrate	VERB
admet-1272	127	28	mics	mic	NOUN
admet-1272	127	29	of	of	ADP
admet-1272	127	30	between	between	ADP
admet-1272	127	31	8	8	NUM
admet-1272	127	32	and	and	CCONJ
admet-1272	127	33	16	16	NUM
admet-1272	127	34	µg	µg	ADV
admet-1272	127	35	ml-1	ml-1	X
admet-1272	127	36	,	,	PUNCT
admet-1272	127	37	against	against	ADP
admet-1272	127	38	microbes	microbe	NOUN
admet-1272	127	39	that	that	PRON
admet-1272	127	40	were	be	AUX
admet-1272	127	41	resistant	resistant	ADJ
admet-1272	127	42	to	to	ADP
admet-1272	127	43	the	the	DET
admet-1272	127	44	unpaired	unpaired	ADJ
admet-1272	127	45	molecules	molecule	NOUN
admet-1272	127	46	with	with	ADP
admet-1272	127	47	no	no	DET
admet-1272	127	48	activities	activity	NOUN
admet-1272	127	49	at	at	ADP
admet-1272	127	50	or	or	CCONJ
admet-1272	127	51	below	below	ADP
admet-1272	127	52	128	128	NUM
admet-1272	127	53	µg	µg	ADV
admet-1272	127	54	ml-1	ml-1	ADV
admet-1272	127	55	for	for	ADP
admet-1272	127	56	the	the	DET
admet-1272	127	57	gram	gram	NOUN
admet-1272	127	58	-	-	PUNCT
admet-1272	127	59	negative	negative	ADJ
admet-1272	127	60	microbes	microbe	NOUN
admet-1272	127	61	except	except	SCONJ
admet-1272	127	62	for	for	ADP
admet-1272	127	63	one	one	NUM
admet-1272	127	64	outlier	outlier	NOUN
admet-1272	127	65	,	,	PUNCT
admet-1272	127	66	the	the	DET
admet-1272	127	67	p.	p.	PROPN
admet-1272	127	68	aeruginosa	aeruginosa	PROPN
admet-1272	127	69	strain	strain	NOUN
admet-1272	127	70	(	(	PUNCT
admet-1272	127	71	atcc	atcc	NOUN
admet-1272	127	72	27853	27853	NUM
admet-1272	127	73	)	)	PUNCT
admet-1272	127	74	that	that	PRON
admet-1272	127	75	gave	give	VERB
admet-1272	127	76	the	the	DET
admet-1272	127	77	only	only	ADJ
admet-1272	127	78	positive	positive	ADJ
admet-1272	127	79	result	result	NOUN
admet-1272	127	80	when	when	SCONJ
admet-1272	127	81	the	the	DET
admet-1272	127	82	unlinked	unlinked	ADJ
admet-1272	127	83	combination	combination	NOUN
admet-1272	127	84	was	be	AUX
admet-1272	127	85	used	use	VERB
admet-1272	127	86	.	.	PUNCT
admet-1272	128	1	as	as	SCONJ
admet-1272	128	2	would	would	AUX
admet-1272	128	3	be	be	AUX
admet-1272	128	4	expected	expect	VERB
admet-1272	128	5	,	,	PUNCT
admet-1272	128	6	against	against	ADP
admet-1272	128	7	the	the	DET
admet-1272	128	8	gram	gram	NOUN
admet-1272	128	9	-	-	PUNCT
admet-1272	128	10	positive	positive	ADJ
admet-1272	128	11	microbes	microbe	NOUN
admet-1272	128	12	significant	significant	ADJ
admet-1272	128	13	activities	activity	NOUN
admet-1272	128	14	were	be	AUX
admet-1272	128	15	seen	see	VERB
admet-1272	128	16	,	,	PUNCT
admet-1272	128	17	even	even	ADV
admet-1272	128	18	as	as	ADV
admet-1272	128	19	low	low	ADJ
admet-1272	128	20	as	as	ADP
admet-1272	128	21	less	less	ADJ
admet-1272	128	22	than	than	ADP
admet-1272	128	23	0.008	0.008	NUM
admet-1272	128	24	µg	µg	NOUN
admet-1272	128	25	ml-1	ml-1	ADV
admet-1272	128	26	for	for	SCONJ
admet-1272	128	27	an	an	DET
admet-1272	128	28	s.	s.	PROPN
admet-1272	128	29	simulans	simulan	NOUN
admet-1272	128	30	strain	strain	VERB
admet-1272	128	31	that	that	PRON
admet-1272	128	32	had	have	VERB
admet-1272	128	33	an	an	DET
admet-1272	128	34	mic	mic	NOUN
admet-1272	128	35	of	of	ADP
admet-1272	128	36	0.125	0.125	NUM
admet-1272	128	37	µg	µg	ADV
admet-1272	128	38	ml-1	ml-1	ADV
admet-1272	128	39	against	against	ADP
admet-1272	128	40	vancomycin	vancomycin	PROPN
admet-1272	128	41	alone	alone	ADV
admet-1272	128	42	.	.	PUNCT
admet-1272	129	1	thus	thus	ADV
admet-1272	129	2	,	,	PUNCT
admet-1272	129	3	in	in	ADP
admet-1272	129	4	contrast	contrast	NOUN
admet-1272	129	5	to	to	ADP
admet-1272	129	6	the	the	DET
admet-1272	129	7	very	very	ADV
admet-1272	129	8	interesting	interesting	ADJ
admet-1272	129	9	boger	boger	NOUN
admet-1272	129	10	compounds	compound	NOUN
admet-1272	129	11	referred	refer	VERB
admet-1272	129	12	to	to	ADP
admet-1272	129	13	earlier	early	ADV
admet-1272	129	14	,	,	PUNCT
admet-1272	129	15	simple	simple	ADJ
admet-1272	129	16	combined	combine	VERB
admet-1272	129	17	“	"	PUNCT
admet-1272	129	18	old	old	ADJ
admet-1272	129	19	”	"	PUNCT
admet-1272	129	20	antibiotics	antibiotic	NOUN
admet-1272	129	21	did	do	AUX
admet-1272	129	22	provide	provide	VERB
admet-1272	129	23	some	some	DET
admet-1272	129	24	excellent	excellent	ADJ
admet-1272	129	25	results	result	NOUN
admet-1272	129	26	.	.	PUNCT
admet-1272	130	1	their	their	PRON
admet-1272	130	2	hemolytic	hemolytic	ADJ
admet-1272	130	3	and	and	CCONJ
admet-1272	130	4	nephrotoxic	nephrotoxic	ADJ
admet-1272	130	5	activities	activity	NOUN
admet-1272	130	6	were	be	AUX
admet-1272	130	7	assessed	assess	VERB
admet-1272	130	8	by	by	ADP
admet-1272	130	9	means	mean	NOUN
admet-1272	130	10	of	of	ADP
admet-1272	130	11	a	a	DET
admet-1272	130	12	viability	viability	NOUN
admet-1272	130	13	assay	assay	VERB
admet-1272	130	14	using	use	VERB
admet-1272	130	15	conditionally	conditionally	ADV
admet-1272	130	16	immortalized	immortalize	VERB
admet-1272	130	17	proximal	proximal	ADJ
admet-1272	130	18	tubule	tubule	ADJ
admet-1272	130	19	epithelial	epithelial	ADJ
admet-1272	130	20	cells	cell	NOUN
admet-1272	130	21	(	(	PUNCT
admet-1272	130	22	ciptecs	ciptecs	NOUN
admet-1272	130	23	)	)	PUNCT
admet-1272	130	24	,	,	PUNCT
admet-1272	130	25	with	with	ADP
admet-1272	130	26	relative	relative	ADJ
admet-1272	130	27	mitochondrial	mitochondrial	ADJ
admet-1272	130	28	activity	activity	NOUN
admet-1272	130	29	after	after	ADP
admet-1272	130	30	24	24	NUM
admet-1272	130	31	h	h	NOUN
admet-1272	130	32	as	as	ADP
admet-1272	130	33	the	the	DET
admet-1272	130	34	end	end	NOUN
admet-1272	130	35	point	point	NOUN
admet-1272	130	36	.	.	PUNCT
admet-1272	131	1	in	in	ADP
admet-1272	131	2	those	those	DET
admet-1272	131	3	assays	assay	NOUN
admet-1272	131	4	,	,	PUNCT
admet-1272	131	5	toxicity	toxicity	NOUN
admet-1272	131	6	arose	arise	VERB
admet-1272	131	7	at	at	ADP
admet-1272	131	8	concentrations	concentration	NOUN
admet-1272	131	9	well	well	ADV
admet-1272	131	10	above	above	ADP
admet-1272	131	11	the	the	DET
admet-1272	131	12	mic	mic	ADJ
admet-1272	131	13	values	value	NOUN
admet-1272	131	14	reported	report	VERB
admet-1272	131	15	.	.	PUNCT
admet-1272	132	1	however	however	ADV
admet-1272	132	2	,	,	PUNCT
admet-1272	132	3	in	in	ADP
admet-1272	132	4	vivo	vivo	NOUN
admet-1272	132	5	activities	activity	NOUN
admet-1272	132	6	and	and	CCONJ
admet-1272	132	7	toxicities	toxicity	NOUN
admet-1272	132	8	were	be	AUX
admet-1272	132	9	not	not	PART
admet-1272	132	10	measured	measure	VERB
admet-1272	132	11	and	and	CCONJ
admet-1272	132	12	would	would	AUX
admet-1272	132	13	have	have	VERB
admet-1272	132	14	to	to	PART
admet-1272	132	15	be	be	AUX
admet-1272	132	16	performed	perform	VERB
admet-1272	132	17	in	in	ADP
admet-1272	132	18	the	the	DET
admet-1272	132	19	future	future	NOUN
admet-1272	132	20	.	.	PUNCT
admet-1272	133	1	figure	figure	VERB
admet-1272	133	2	4	4	NUM
admet-1272	133	3	.	.	PUNCT
admet-1272	133	4	colistin	colistin	NOUN
admet-1272	133	5	and	and	CCONJ
admet-1272	133	6	polymyxin	polymyxin	ADJ
admet-1272	133	7	derivatives	derivative	NOUN
admet-1272	133	8	;	;	PUNCT
admet-1272	133	9	structures	structure	NOUN
admet-1272	133	10	13	13	NUM
admet-1272	133	11	to	to	PART
admet-1272	133	12	17	17	NUM
admet-1272	133	13	admet	admet	X
admet-1272	133	14	&	&	CCONJ
admet-1272	133	15	dmpk	dmpk	PROPN
admet-1272	133	16	10(2	10(2	NUM
admet-1272	133	17	)	)	PUNCT
admet-1272	133	18	(	(	PUNCT
admet-1272	133	19	2022	2022	NUM
admet-1272	133	20	)	)	PUNCT
admet-1272	133	21	131	131	NUM
admet-1272	133	22	-	-	SYM
admet-1272	133	23	146	146	NUM
admet-1272	133	24	chemical	chemical	NOUN
admet-1272	133	25	syntheses	synthesis	NOUN
admet-1272	133	26	and	and	CCONJ
admet-1272	133	27	resistant	resistant	ADJ
admet-1272	133	28	antibiotics	antibiotic	NOUN
admet-1272	133	29	doi	doi	NOUN
admet-1272	133	30	:	:	PUNCT
admet-1272	133	31	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	VERB
admet-1272	133	32	139	139	NUM
admet-1272	133	33	antibacterial	antibacterial	ADJ
admet-1272	133	34	-	-	PUNCT
admet-1272	133	35	active	active	ADJ
admet-1272	133	36	cyclic	cyclic	ADJ
admet-1272	133	37	peptides	peptide	NOUN
admet-1272	133	38	(	(	PUNCT
admet-1272	133	39	excluding	exclude	VERB
admet-1272	133	40	polymyxins	polymyxin	NOUN
admet-1272	133	41	and	and	CCONJ
admet-1272	133	42	colistins	colistin	NOUN
admet-1272	133	43	)	)	PUNCT
admet-1272	133	44	what	what	PRON
admet-1272	133	45	is	be	AUX
admet-1272	133	46	not	not	PART
admet-1272	133	47	often	often	ADV
admet-1272	133	48	realized	realize	VERB
admet-1272	133	49	is	be	AUX
admet-1272	133	50	that	that	SCONJ
admet-1272	133	51	the	the	DET
admet-1272	133	52	first	first	ADJ
admet-1272	133	53	natural	natural	ADJ
admet-1272	133	54	product	product	NOUN
admet-1272	133	55	antibiotic	antibiotic	ADJ
admet-1272	133	56	to	to	PART
admet-1272	133	57	go	go	VERB
admet-1272	133	58	into	into	ADP
admet-1272	133	59	clinical	clinical	ADJ
admet-1272	133	60	use	use	NOUN
admet-1272	133	61	but	but	CCONJ
admet-1272	133	62	not	not	PART
admet-1272	133	63	under	under	ADP
admet-1272	133	64	terms	term	NOUN
admet-1272	133	65	equivalent	equivalent	ADJ
admet-1272	133	66	to	to	ADP
admet-1272	133	67	formal	formal	ADJ
admet-1272	133	68	approval	approval	NOUN
admet-1272	133	69	as	as	ADP
admet-1272	133	70	a	a	DET
admet-1272	133	71	drug	drug	NOUN
admet-1272	133	72	entity	entity	NOUN
admet-1272	133	73	in	in	ADP
admet-1272	133	74	the	the	DET
admet-1272	133	75	modern	modern	ADJ
admet-1272	133	76	sense	sense	NOUN
admet-1272	133	77	,	,	PUNCT
admet-1272	133	78	was	be	AUX
admet-1272	133	79	not	not	PART
admet-1272	133	80	penicillin	penicillin	NOUN
admet-1272	133	81	as	as	SCONJ
admet-1272	133	82	most	most	ADJ
admet-1272	133	83	people	people	NOUN
admet-1272	133	84	think	think	VERB
admet-1272	133	85	,	,	PUNCT
admet-1272	133	86	but	but	CCONJ
admet-1272	133	87	the	the	DET
admet-1272	133	88	cyclic	cyclic	ADJ
admet-1272	133	89	peptide	peptide	NOUN
admet-1272	133	90	tyrocidine	tyrocidine	NOUN
admet-1272	133	91	and	and	CCONJ
admet-1272	133	92	the	the	DET
admet-1272	133	93	probable	probable	ADJ
admet-1272	133	94	second	second	NOUN
admet-1272	133	95	,	,	PUNCT
admet-1272	133	96	a	a	DET
admet-1272	133	97	derivative	derivative	NOUN
admet-1272	133	98	of	of	ADP
admet-1272	133	99	“	"	PUNCT
admet-1272	133	100	gramicidin	gramicidin	NOUN
admet-1272	133	101	”	"	PUNCT
admet-1272	133	102	that	that	PRON
admet-1272	133	103	was	be	AUX
admet-1272	133	104	initially	initially	ADV
admet-1272	133	105	mentioned	mention	VERB
admet-1272	133	106	in	in	ADP
admet-1272	133	107	a	a	DET
admet-1272	133	108	1940	1940	NUM
admet-1272	133	109	report	report	NOUN
admet-1272	133	110	[	[	X
admet-1272	133	111	26	26	NUM
admet-1272	133	112	]	]	PUNCT
admet-1272	133	113	,	,	PUNCT
admet-1272	133	114	with	with	ADP
admet-1272	133	115	the	the	DET
admet-1272	133	116	structure	structure	NOUN
admet-1272	133	117	of	of	ADP
admet-1272	133	118	tyrocidine	tyrocidine	NOUN
admet-1272	133	119	a	a	DET
admet-1272	133	120	(	(	PUNCT
admet-1272	133	121	18	18	NUM
admet-1272	133	122	)	)	PUNCT
admet-1272	133	123	,	,	PUNCT
admet-1272	133	124	reported	report	VERB
admet-1272	133	125	later	later	ADV
admet-1272	133	126	in	in	ADP
admet-1272	133	127	1952	1952	NUM
admet-1272	133	128	[	[	X
admet-1272	133	129	27	27	NUM
admet-1272	133	130	]	]	PUNCT
admet-1272	133	131	.	.	PUNCT
admet-1272	134	1	these	these	DET
admet-1272	134	2	two	two	NUM
admet-1272	134	3	molecules	molecule	NOUN
admet-1272	134	4	are	be	AUX
admet-1272	134	5	usually	usually	ADV
admet-1272	134	6	not	not	PART
admet-1272	134	7	mentioned	mention	VERB
admet-1272	134	8	in	in	ADP
admet-1272	134	9	any	any	DET
admet-1272	134	10	discussion	discussion	NOUN
admet-1272	134	11	of	of	ADP
admet-1272	134	12	early	early	ADJ
admet-1272	134	13	antibiotics	antibiotic	NOUN
admet-1272	134	14	.	.	PUNCT
admet-1272	135	1	however	however	ADV
admet-1272	135	2	,	,	PUNCT
admet-1272	135	3	contrary	contrary	ADV
admet-1272	135	4	to	to	ADP
admet-1272	135	5	what	what	PRON
admet-1272	135	6	most	most	ADJ
admet-1272	135	7	people	people	NOUN
admet-1272	135	8	in	in	ADP
admet-1272	135	9	the	the	DET
admet-1272	135	10	west	west	NOUN
admet-1272	135	11	may	may	AUX
admet-1272	135	12	think	think	VERB
admet-1272	135	13	,	,	PUNCT
admet-1272	135	14	the	the	DET
admet-1272	135	15	aminoglycoside	aminoglycoside	ADJ
admet-1272	135	16	streptomycin	streptomycin	PROPN
admet-1272	135	17	(	(	PUNCT
admet-1272	135	18	19	19	NUM
admet-1272	135	19	)	)	PUNCT
admet-1272	135	20	was	be	AUX
admet-1272	135	21	not	not	PART
admet-1272	135	22	the	the	DET
admet-1272	135	23	next	next	ADJ
admet-1272	135	24	antibiotic	antibiotic	NOUN
admet-1272	135	25	to	to	PART
admet-1272	135	26	go	go	VERB
admet-1272	135	27	into	into	ADP
admet-1272	135	28	use	use	NOUN
admet-1272	135	29	for	for	ADP
admet-1272	135	30	battlefield	battlefield	NOUN
admet-1272	135	31	wounds	wound	NOUN
admet-1272	135	32	at	at	ADP
admet-1272	135	33	around	around	ADP
admet-1272	135	34	the	the	DET
admet-1272	135	35	same	same	ADJ
admet-1272	135	36	time	time	NOUN
admet-1272	135	37	as	as	ADP
admet-1272	135	38	penicillin	penicillin	NOUN
admet-1272	135	39	in	in	ADP
admet-1272	135	40	world	world	PROPN
admet-1272	135	41	war	war	PROPN
admet-1272	135	42	ii	ii	PROPN
admet-1272	135	43	.	.	PUNCT
admet-1272	136	1	the	the	DET
admet-1272	136	2	next	next	ADJ
admet-1272	136	3	antibiotic	antibiotic	NOUN
admet-1272	136	4	to	to	PART
admet-1272	136	5	go	go	VERB
admet-1272	136	6	into	into	ADP
admet-1272	136	7	use	use	NOUN
admet-1272	136	8	for	for	ADP
admet-1272	136	9	these	these	DET
admet-1272	136	10	conditions	condition	NOUN
admet-1272	136	11	was	be	AUX
admet-1272	136	12	gramicidin	gramicidin	NOUN
admet-1272	136	13	s	s	PROPN
admet-1272	136	14	(	(	PUNCT
admet-1272	136	15	20	20	NUM
admet-1272	136	16	)	)	PUNCT
admet-1272	136	17	,	,	PUNCT
admet-1272	136	18	first	first	ADV
admet-1272	136	19	used	use	VERB
admet-1272	136	20	by	by	ADP
admet-1272	136	21	the	the	DET
admet-1272	136	22	ussr	ussr	PROPN
admet-1272	136	23	for	for	ADP
admet-1272	136	24	battlefield	battlefield	ADJ
admet-1272	136	25	injuries	injury	NOUN
admet-1272	136	26	in	in	ADP
admet-1272	136	27	1943	1943	NUM
admet-1272	136	28	[	[	X
admet-1272	136	29	28,29	28,29	NUM
admet-1272	136	30	]	]	PUNCT
admet-1272	136	31	.	.	PUNCT
admet-1272	137	1	further	further	ADJ
admet-1272	137	2	reports	report	NOUN
admet-1272	137	3	in	in	ADP
admet-1272	137	4	the	the	DET
admet-1272	137	5	same	same	ADJ
admet-1272	137	6	basic	basic	ADJ
admet-1272	137	7	time	time	NOUN
admet-1272	137	8	frame	frame	NOUN
admet-1272	137	9	from	from	ADP
admet-1272	137	10	the	the	DET
admet-1272	137	11	then	then	ADV
admet-1272	137	12	ussr	ussr	ADJ
admet-1272	137	13	,	,	PUNCT
admet-1272	137	14	covered	cover	VERB
admet-1272	137	15	more	more	ADJ
admet-1272	137	16	clinical	clinical	ADJ
admet-1272	137	17	aspects	aspect	NOUN
admet-1272	138	1	[	[	X
admet-1272	138	2	30,31	30,31	NOUN
admet-1272	138	3	]	]	PUNCT
admet-1272	138	4	.	.	PUNCT
admet-1272	139	1	then	then	ADV
admet-1272	139	2	in	in	ADP
admet-1272	139	3	1946	1946	NUM
admet-1272	139	4	,	,	PUNCT
admet-1272	139	5	gause	gause	PROPN
admet-1272	139	6	discussed	discuss	VERB
admet-1272	139	7	the	the	DET
admet-1272	139	8	large	large	ADJ
admet-1272	139	9	-	-	PUNCT
admet-1272	139	10	scale	scale	NOUN
admet-1272	139	11	production	production	NOUN
admet-1272	139	12	and	and	CCONJ
admet-1272	139	13	chemistry	chemistry	NOUN
admet-1272	139	14	of	of	ADP
admet-1272	139	15	this	this	DET
admet-1272	139	16	agent	agent	NOUN
admet-1272	139	17	[	[	X
admet-1272	139	18	32	32	NUM
admet-1272	139	19	]	]	PUNCT
admet-1272	139	20	.	.	PUNCT
admet-1272	140	1	even	even	ADV
admet-1272	140	2	today	today	NOUN
admet-1272	140	3	,	,	PUNCT
admet-1272	140	4	variations	variation	NOUN
admet-1272	140	5	on	on	ADP
admet-1272	140	6	this	this	DET
admet-1272	140	7	cyclic	cyclic	ADJ
admet-1272	140	8	peptide	peptide	NOUN
admet-1272	140	9	are	be	AUX
admet-1272	140	10	still	still	ADV
admet-1272	140	11	being	be	AUX
admet-1272	140	12	investigated	investigate	VERB
admet-1272	140	13	.	.	PUNCT
admet-1272	141	1	very	very	ADV
admet-1272	141	2	recently	recently	ADV
admet-1272	141	3	there	there	PRON
admet-1272	141	4	have	have	AUX
admet-1272	141	5	been	be	AUX
admet-1272	141	6	three	three	NUM
admet-1272	141	7	reviews	review	NOUN
admet-1272	141	8	relating	relate	VERB
admet-1272	141	9	to	to	ADP
admet-1272	141	10	antimicrobial	antimicrobial	ADJ
admet-1272	141	11	peptides	peptide	NOUN
admet-1272	141	12	from	from	ADP
admet-1272	141	13	naturally	naturally	ADV
admet-1272	141	14	occurring	occur	VERB
admet-1272	141	15	and	and	CCONJ
admet-1272	141	16	synthetic	synthetic	ADJ
admet-1272	141	17	sources	source	NOUN
admet-1272	141	18	.	.	PUNCT
admet-1272	142	1	in	in	ADP
admet-1272	142	2	2020	2020	NUM
admet-1272	142	3	,	,	PUNCT
admet-1272	142	4	an	an	DET
admet-1272	142	5	excellent	excellent	ADJ
admet-1272	142	6	review	review	NOUN
admet-1272	142	7	by	by	ADP
admet-1272	142	8	lazzaro	lazzaro	PROPN
admet-1272	142	9	et	et	PROPN
admet-1272	142	10	al	al	PROPN
admet-1272	143	1	[	[	X
admet-1272	143	2	33	33	NUM
admet-1272	143	3	]	]	PUNCT
admet-1272	143	4	discussed	discuss	VERB
admet-1272	143	5	the	the	DET
admet-1272	143	6	evolution	evolution	NOUN
admet-1272	143	7	of	of	ADP
admet-1272	143	8	antimicrobial	antimicrobial	ADJ
admet-1272	143	9	peptides	peptide	NOUN
admet-1272	143	10	.	.	PUNCT
admet-1272	144	1	in	in	ADP
admet-1272	144	2	this	this	DET
admet-1272	144	3	paper	paper	NOUN
admet-1272	144	4	they	they	PRON
admet-1272	144	5	suggested	suggest	VERB
admet-1272	144	6	that	that	SCONJ
admet-1272	144	7	there	there	PRON
admet-1272	144	8	was	be	VERB
admet-1272	144	9	evidence	evidence	NOUN
admet-1272	144	10	showing	show	VERB
admet-1272	144	11	adaptive	adaptive	ADJ
admet-1272	144	12	maintenance	maintenance	NOUN
admet-1272	144	13	of	of	ADP
admet-1272	144	14	polymorphism	polymorphism	NOUN
admet-1272	144	15	in	in	ADP
admet-1272	144	16	amp	amp	NOUN
admet-1272	144	17	genes	gene	NOUN
admet-1272	144	18	,	,	PUNCT
admet-1272	144	19	and	and	CCONJ
admet-1272	144	20	perhaps	perhaps	ADV
admet-1272	144	21	adaptative	adaptative	ADJ
admet-1272	144	22	loss	loss	NOUN
admet-1272	144	23	of	of	ADP
admet-1272	144	24	amp	amp	NOUN
admet-1272	144	25	activity	activity	NOUN
admet-1272	144	26	.	.	PUNCT
admet-1272	145	1	they	they	PRON
admet-1272	145	2	also	also	ADV
admet-1272	145	3	suggested	suggest	VERB
admet-1272	145	4	as	as	SCONJ
admet-1272	145	5	shown	show	VERB
admet-1272	145	6	earlier	early	ADV
admet-1272	145	7	with	with	ADP
admet-1272	145	8	the	the	DET
admet-1272	145	9	polymyxins	polymyxin	NOUN
admet-1272	145	10	/	/	SYM
admet-1272	145	11	colistins	colistin	NOUN
admet-1272	145	12	,	,	PUNCT
admet-1272	145	13	that	that	DET
admet-1272	145	14	synergy	synergy	NOUN
admet-1272	145	15	might	might	AUX
admet-1272	145	16	well	well	ADV
admet-1272	145	17	occur	occur	VERB
admet-1272	145	18	with	with	ADP
admet-1272	145	19	“	"	PUNCT
admet-1272	145	20	conventional	conventional	ADJ
admet-1272	145	21	antibiotics	antibiotic	NOUN
admet-1272	145	22	”	"	PUNCT
admet-1272	145	23	.	.	PUNCT
admet-1272	146	1	what	what	PRON
admet-1272	146	2	is	be	AUX
admet-1272	146	3	interesting	interesting	ADJ
admet-1272	146	4	,	,	PUNCT
admet-1272	146	5	is	be	AUX
admet-1272	146	6	that	that	SCONJ
admet-1272	146	7	they	they	PRON
admet-1272	146	8	show	show	VERB
admet-1272	146	9	synergy	synergy	NOUN
admet-1272	146	10	between	between	ADP
admet-1272	146	11	magainin	magainin	PROPN
admet-1272	146	12	2	2	NUM
admet-1272	146	13	and	and	CCONJ
admet-1272	146	14	the	the	DET
admet-1272	146	15	amp	amp	PROPN
admet-1272	146	16	pgla	pgla	PROPN
admet-1272	147	1	[	[	X
admet-1272	147	2	34	34	NUM
admet-1272	147	3	]	]	X
admet-1272	147	4	both	both	PRON
admet-1272	147	5	of	of	ADP
admet-1272	147	6	which	which	PRON
admet-1272	147	7	are	be	AUX
admet-1272	147	8	amps	amp	NOUN
admet-1272	147	9	found	find	VERB
admet-1272	147	10	in	in	ADP
admet-1272	147	11	the	the	DET
admet-1272	147	12	skin	skin	NOUN
admet-1272	147	13	of	of	ADP
admet-1272	147	14	the	the	DET
admet-1272	147	15	african	african	ADJ
admet-1272	147	16	frog	frog	PROPN
admet-1272	147	17	xenopus	xenopus	PROPN
admet-1272	147	18	laevis	laevis	NOUN
admet-1272	147	19	and	and	CCONJ
admet-1272	147	20	eukaryotes	eukaryote	NOUN
admet-1272	147	21	can	can	AUX
admet-1272	147	22	rapidly	rapidly	ADV
admet-1272	147	23	deploy	deploy	VERB
admet-1272	147	24	multiple	multiple	ADJ
admet-1272	147	25	distinct	distinct	ADJ
admet-1272	147	26	classes	class	NOUN
admet-1272	147	27	of	of	ADP
admet-1272	147	28	amps	amp	NOUN
admet-1272	147	29	simultaneously	simultaneously	ADV
admet-1272	147	30	.	.	PUNCT
admet-1272	148	1	although	although	SCONJ
admet-1272	148	2	it	it	PRON
admet-1272	148	3	was	be	AUX
admet-1272	148	4	always	always	ADV
admet-1272	148	5	thought	think	VERB
admet-1272	148	6	that	that	SCONJ
admet-1272	148	7	amps	amp	NOUN
admet-1272	148	8	have	have	VERB
admet-1272	148	9	broad	broad	ADJ
admet-1272	148	10	spectrum	spectrum	NOUN
admet-1272	148	11	activities	activity	NOUN
admet-1272	148	12	,	,	PUNCT
admet-1272	148	13	genetic	genetic	ADJ
admet-1272	148	14	disruption	disruption	NOUN
admet-1272	148	15	of	of	ADP
admet-1272	148	16	amp	amp	NOUN
admet-1272	148	17	genes	gene	NOUN
admet-1272	148	18	result	result	VERB
admet-1272	148	19	in	in	ADP
admet-1272	148	20	different	different	ADJ
admet-1272	148	21	responses	response	NOUN
admet-1272	148	22	to	to	ADP
admet-1272	148	23	infections	infection	NOUN
admet-1272	148	24	by	by	ADP
admet-1272	148	25	s.	s.	PROPN
admet-1272	148	26	aureus	aureus	PROPN
admet-1272	148	27	in	in	ADP
admet-1272	148	28	the	the	DET
admet-1272	148	29	beetle	beetle	NOUN
admet-1272	149	1	tenbrio	tenbrio	NOUN
admet-1272	149	2	molitor	molitor	NOUN
admet-1272	149	3	.	.	PUNCT
admet-1272	150	1	similar	similar	ADJ
admet-1272	150	2	separation	separation	NOUN
admet-1272	150	3	of	of	ADP
admet-1272	150	4	activities	activity	NOUN
admet-1272	150	5	/	/	SYM
admet-1272	150	6	genes	gene	NOUN
admet-1272	150	7	in	in	ADP
admet-1272	150	8	other	other	ADJ
admet-1272	150	9	insects	insect	NOUN
admet-1272	150	10	have	have	AUX
admet-1272	150	11	caused	cause	VERB
admet-1272	150	12	an	an	DET
admet-1272	150	13	alteration	alteration	NOUN
admet-1272	150	14	in	in	ADP
admet-1272	150	15	the	the	DET
admet-1272	150	16	idea	idea	NOUN
admet-1272	150	17	that	that	SCONJ
admet-1272	150	18	“	"	PUNCT
admet-1272	150	19	broad	broad	ADJ
admet-1272	150	20	spectrum	spectrum	NOUN
admet-1272	150	21	responses	response	NOUN
admet-1272	150	22	”	"	PUNCT
admet-1272	150	23	may	may	AUX
admet-1272	150	24	not	not	PART
admet-1272	150	25	be	be	AUX
admet-1272	150	26	the	the	DET
admet-1272	150	27	case	case	NOUN
admet-1272	150	28	every	every	DET
admet-1272	150	29	time	time	NOUN
admet-1272	150	30	,	,	PUNCT
admet-1272	150	31	but	but	CCONJ
admet-1272	150	32	specificity	specificity	NOUN
admet-1272	150	33	in	in	ADP
admet-1272	150	34	responses	response	NOUN
admet-1272	150	35	appears	appear	VERB
admet-1272	150	36	to	to	PART
admet-1272	150	37	be	be	AUX
admet-1272	150	38	one	one	NUM
admet-1272	150	39	response	response	NOUN
admet-1272	150	40	across	across	ADP
admet-1272	150	41	many	many	ADJ
admet-1272	150	42	eukaryotic	eukaryotic	ADJ
admet-1272	150	43	phyla	phyla	NOUN
admet-1272	150	44	.	.	PUNCT
admet-1272	151	1	in	in	ADP
admet-1272	151	2	2021	2021	NUM
admet-1272	151	3	a	a	DET
admet-1272	151	4	group	group	NOUN
admet-1272	151	5	from	from	ADP
admet-1272	151	6	malaysia	malaysia	PROPN
admet-1272	152	1	[	[	X
admet-1272	152	2	35	35	NUM
admet-1272	152	3	]	]	PUNCT
admet-1272	152	4	reported	report	VERB
admet-1272	152	5	the	the	DET
admet-1272	152	6	results	result	NOUN
admet-1272	152	7	of	of	ADP
admet-1272	152	8	a	a	DET
admet-1272	152	9	literature	literature	NOUN
admet-1272	152	10	review	review	NOUN
admet-1272	152	11	from	from	ADP
admet-1272	152	12	2011	2011	NUM
admet-1272	152	13	to	to	ADP
admet-1272	152	14	2021	2021	NUM
admet-1272	152	15	using	use	VERB
admet-1272	152	16	a	a	DET
admet-1272	152	17	variety	variety	NOUN
admet-1272	152	18	of	of	ADP
admet-1272	152	19	available	available	ADJ
admet-1272	152	20	databases	database	NOUN
admet-1272	152	21	.	.	PUNCT
admet-1272	153	1	table	table	NOUN
admet-1272	153	2	1	1	NUM
admet-1272	153	3	in	in	ADP
admet-1272	153	4	that	that	DET
admet-1272	153	5	review	review	NOUN
admet-1272	153	6	(	(	PUNCT
admet-1272	153	7	which	which	PRON
admet-1272	153	8	is	be	AUX
admet-1272	153	9	an	an	DET
admet-1272	153	10	open	open	ADJ
admet-1272	153	11	access	access	NOUN
admet-1272	153	12	paper	paper	NOUN
admet-1272	153	13	)	)	PUNCT
admet-1272	153	14	covers	cover	VERB
admet-1272	153	15	analogies	analogy	NOUN
admet-1272	153	16	between	between	ADP
admet-1272	153	17	naturally	naturally	ADV
admet-1272	153	18	occurring	occur	VERB
admet-1272	153	19	and	and	CCONJ
admet-1272	153	20	synthetic	synthetic	ADJ
admet-1272	153	21	agents	agent	NOUN
admet-1272	153	22	,	,	PUNCT
admet-1272	153	23	with	with	ADP
admet-1272	153	24	the	the	DET
admet-1272	153	25	rest	rest	NOUN
admet-1272	153	26	of	of	ADP
admet-1272	153	27	the	the	DET
admet-1272	153	28	review	review	NOUN
admet-1272	153	29	covering	cover	VERB
admet-1272	153	30	methodologies	methodology	NOUN
admet-1272	153	31	and	and	CCONJ
admet-1272	153	32	some	some	DET
admet-1272	153	33	history	history	NOUN
admet-1272	153	34	of	of	ADP
admet-1272	153	35	both	both	CCONJ
admet-1272	153	36	natural	natural	ADJ
admet-1272	153	37	and	and	CCONJ
admet-1272	153	38	synthetic	synthetic	ADJ
admet-1272	153	39	amps	amp	NOUN
admet-1272	153	40	,	,	PUNCT
admet-1272	153	41	with	with	ADP
admet-1272	153	42	an	an	DET
admet-1272	153	43	up	up	ADP
admet-1272	153	44	-	-	PUNCT
admet-1272	153	45	to	to	ADP
admet-1272	153	46	-	-	PUNCT
admet-1272	153	47	date	date	NOUN
admet-1272	153	48	series	series	NOUN
admet-1272	153	49	of	of	ADP
admet-1272	153	50	references	reference	NOUN
admet-1272	153	51	[	[	X
admet-1272	153	52	35	35	NUM
admet-1272	153	53	]	]	PUNCT
admet-1272	153	54	.	.	PUNCT
admet-1272	154	1	closely	closely	ADV
admet-1272	154	2	following	follow	VERB
admet-1272	154	3	the	the	DET
admet-1272	154	4	malaysian	malaysian	ADJ
admet-1272	154	5	paper	paper	NOUN
admet-1272	154	6	was	be	AUX
admet-1272	154	7	one	one	NUM
admet-1272	154	8	from	from	ADP
admet-1272	154	9	an	an	DET
admet-1272	154	10	italian	italian	ADJ
admet-1272	154	11	group	group	NOUN
admet-1272	154	12	covering	cover	VERB
admet-1272	154	13	semisynthetic	semisynthetic	ADJ
admet-1272	154	14	and	and	CCONJ
admet-1272	154	15	synthetic	synthetic	ADJ
admet-1272	154	16	amps	amp	NOUN
admet-1272	154	17	,	,	PUNCT
admet-1272	154	18	with	with	ADP
admet-1272	154	19	an	an	DET
admet-1272	154	20	extension	extension	NOUN
admet-1272	154	21	into	into	ADP
admet-1272	154	22	some	some	PRON
admet-1272	154	23	with	with	ADP
admet-1272	154	24	antifungal	antifungal	ADJ
admet-1272	154	25	and	and	CCONJ
admet-1272	154	26	antiviral	antiviral	ADJ
admet-1272	154	27	activities	activity	NOUN
admet-1272	154	28	[	[	X
admet-1272	154	29	36	36	NUM
admet-1272	154	30	]	]	PUNCT
admet-1272	154	31	.	.	PUNCT
admet-1272	155	1	this	this	DET
admet-1272	155	2	review	review	NOUN
admet-1272	155	3	finishes	finish	VERB
admet-1272	155	4	with	with	ADP
admet-1272	155	5	a	a	DET
admet-1272	155	6	comment	comment	NOUN
admet-1272	155	7	on	on	ADP
admet-1272	155	8	the	the	DET
admet-1272	155	9	semisynthetic	semisynthetic	ADJ
admet-1272	155	10	amp	amp	NOUN
admet-1272	155	11	murepavadin	murepavadin	NOUN
admet-1272	155	12	(	(	PUNCT
admet-1272	155	13	21	21	NUM
admet-1272	155	14	)	)	PUNCT
admet-1272	155	15	,	,	PUNCT
admet-1272	155	16	a	a	DET
admet-1272	155	17	cyclic	cyclic	ADJ
admet-1272	155	18	beta	beta	NOUN
admet-1272	155	19	hairpin	hairpin	NOUN
admet-1272	155	20	peptidomimetic	peptidomimetic	NOUN
admet-1272	155	21	based	base	VERB
admet-1272	155	22	on	on	ADP
admet-1272	155	23	the	the	DET
admet-1272	155	24	antimicrobial	antimicrobial	ADJ
admet-1272	155	25	peptide	peptide	NOUN
admet-1272	155	26	,	,	PUNCT
admet-1272	155	27	protegrin	protegrin	NOUN
admet-1272	155	28	(	(	PUNCT
admet-1272	155	29	pg-1	pg-1	NUM
admet-1272	155	30	)	)	PUNCT
admet-1272	155	31	.	.	PUNCT
admet-1272	156	1	it	it	PRON
admet-1272	156	2	is	be	AUX
admet-1272	156	3	nonlytic	nonlytic	ADJ
admet-1272	156	4	and	and	CCONJ
admet-1272	156	5	targeted	target	VERB
admet-1272	156	6	the	the	DET
admet-1272	156	7	lptd	lptd	NOUN
admet-1272	156	8	protein	protein	NOUN
admet-1272	156	9	transporter	transporter	NOUN
admet-1272	156	10	in	in	ADP
admet-1272	156	11	p.	p.	PROPN
admet-1272	156	12	aeruginosa	aeruginosa	PROPN
admet-1272	156	13	.	.	PUNCT
admet-1272	157	1	it	it	PRON
admet-1272	157	2	reached	reach	VERB
admet-1272	157	3	phase	phase	NOUN
admet-1272	157	4	iii	iii	NUM
admet-1272	157	5	clinical	clinical	ADJ
admet-1272	157	6	trials	trial	NOUN
admet-1272	157	7	as	as	ADP
admet-1272	157	8	an	an	DET
admet-1272	157	9	iv	iv	NOUN
admet-1272	157	10	-	-	PUNCT
admet-1272	157	11	preparation	preparation	NOUN
admet-1272	157	12	against	against	ADP
admet-1272	157	13	pneumonia	pneumonia	NOUN
admet-1272	157	14	,	,	PUNCT
admet-1272	157	15	but	but	CCONJ
admet-1272	157	16	in	in	ADP
admet-1272	157	17	july	july	PROPN
admet-1272	157	18	2019	2019	NUM
admet-1272	157	19	,	,	PUNCT
admet-1272	157	20	the	the	DET
admet-1272	157	21	two	two	NUM
admet-1272	157	22	trials	trial	NOUN
admet-1272	157	23	were	be	AUX
admet-1272	157	24	terminated	terminate	VERB
admet-1272	157	25	due	due	ADP
admet-1272	157	26	to	to	ADP
admet-1272	157	27	high	high	ADJ
admet-1272	157	28	levels	level	NOUN
admet-1272	157	29	of	of	ADP
admet-1272	157	30	unexpected	unexpected	ADJ
admet-1272	157	31	kidney	kidney	NOUN
admet-1272	157	32	injury	injury	NOUN
admet-1272	157	33	.	.	PUNCT
admet-1272	158	1	in	in	ADP
admet-1272	158	2	december	december	PROPN
admet-1272	158	3	2020	2020	NUM
admet-1272	158	4	,	,	PUNCT
admet-1272	158	5	the	the	DET
admet-1272	158	6	uk	uk	PROPN
admet-1272	158	7	medicines	medicine	NOUN
admet-1272	158	8	agency	agency	NOUN
admet-1272	158	9	permitted	permit	VERB
admet-1272	158	10	a	a	DET
admet-1272	158	11	phase	phase	NOUN
admet-1272	158	12	i	i	PRON
admet-1272	158	13	trial	trial	NOUN
admet-1272	158	14	to	to	PART
admet-1272	158	15	begin	begin	VERB
admet-1272	158	16	targeting	target	VERB
admet-1272	158	17	oral	oral	ADJ
admet-1272	158	18	inhalation	inhalation	NOUN
admet-1272	158	19	route	route	NOUN
admet-1272	158	20	in	in	ADP
admet-1272	158	21	people	people	NOUN
admet-1272	158	22	with	with	ADP
admet-1272	158	23	cystic	cystic	ADJ
admet-1272	158	24	fibrosis	fibrosis	NOUN
admet-1272	158	25	who	who	PRON
admet-1272	158	26	are	be	AUX
admet-1272	158	27	infected	infect	VERB
admet-1272	158	28	with	with	ADP
admet-1272	158	29	p.	p.	PROPN
admet-1272	158	30	aeruginosa	aeruginosa	PROPN
admet-1272	158	31	.	.	PUNCT
admet-1272	159	1	an	an	DET
admet-1272	159	2	excellent	excellent	ADJ
admet-1272	159	3	and	and	CCONJ
admet-1272	159	4	very	very	ADV
admet-1272	159	5	recent	recent	ADJ
admet-1272	159	6	paper	paper	NOUN
admet-1272	159	7	that	that	PRON
admet-1272	159	8	covers	cover	VERB
admet-1272	159	9	some	some	PRON
admet-1272	159	10	of	of	ADP
admet-1272	159	11	the	the	DET
admet-1272	159	12	above	above	ADJ
admet-1272	159	13	examples	example	NOUN
admet-1272	159	14	,	,	PUNCT
admet-1272	159	15	and	and	CCONJ
admet-1272	159	16	other	other	ADJ
admet-1272	159	17	potential	potential	ADJ
admet-1272	159	18	agents	agent	NOUN
admet-1272	159	19	that	that	PRON
admet-1272	159	20	can	can	AUX
admet-1272	159	21	be	be	AUX
admet-1272	159	22	targeted	target	VERB
admet-1272	159	23	against	against	ADP
admet-1272	159	24	the	the	DET
admet-1272	159	25	outer	outer	ADJ
admet-1272	159	26	membrane(s	membrane(s	NOUN
admet-1272	159	27	)	)	PUNCT
admet-1272	159	28	of	of	ADP
admet-1272	159	29	gram	gram	NOUN
admet-1272	159	30	-	-	PUNCT
admet-1272	159	31	negative	negative	ADJ
admet-1272	159	32	microbes	microbe	NOUN
admet-1272	159	33	,	,	PUNCT
admet-1272	159	34	is	be	AUX
admet-1272	159	35	the	the	DET
admet-1272	159	36	review	review	NOUN
admet-1272	159	37	by	by	ADP
admet-1272	159	38	klobucar	klobucar	NOUN
admet-1272	159	39	and	and	CCONJ
admet-1272	159	40	brown	brown	ADJ
admet-1272	159	41	in	in	ADP
admet-1272	159	42	2022	2022	NUM
admet-1272	159	43	that	that	PRON
admet-1272	159	44	should	should	AUX
admet-1272	159	45	be	be	AUX
admet-1272	159	46	consulted	consult	VERB
admet-1272	159	47	as	as	SCONJ
admet-1272	159	48	they	they	PRON
admet-1272	159	49	cover	cover	VERB
admet-1272	159	50	other	other	ADJ
admet-1272	159	51	agents	agent	NOUN
admet-1272	159	52	as	as	ADV
admet-1272	159	53	well	well	ADV
admet-1272	159	54	[	[	X
admet-1272	159	55	37	37	NUM
admet-1272	159	56	]	]	PUNCT
admet-1272	159	57	.	.	PUNCT
admet-1272	160	1	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	PROPN
admet-1272	161	1	david	david	PROPN
admet-1272	161	2	j.	j.	PROPN
admet-1272	161	3	newman	newman	PROPN
admet-1272	161	4	admet	admet	PROPN
admet-1272	161	5	&	&	CCONJ
admet-1272	161	6	dmpk	dmpk	PROPN
admet-1272	161	7	10(2	10(2	NUM
admet-1272	161	8	)	)	PUNCT
admet-1272	161	9	(	(	PUNCT
admet-1272	161	10	2022	2022	NUM
admet-1272	161	11	)	)	PUNCT
admet-1272	161	12	131	131	NUM
admet-1272	161	13	-	-	SYM
admet-1272	161	14	146	146	NUM
admet-1272	161	15	140	140	NUM
admet-1272	161	16	figure	figure	NOUN
admet-1272	161	17	5	5	NUM
admet-1272	161	18	.	.	PUNCT
admet-1272	162	1	early	early	ADJ
admet-1272	162	2	(	(	PUNCT
admet-1272	162	3	1943	1943	NUM
admet-1272	162	4	)	)	PUNCT
admet-1272	162	5	and	and	CCONJ
admet-1272	162	6	late	late	ADV
admet-1272	162	7	(	(	PUNCT
admet-1272	162	8	2010	2010	NUM
admet-1272	162	9	plus	plus	CCONJ
admet-1272	162	10	)	)	PUNCT
admet-1272	162	11	antibiotics	antibiotic	NOUN
admet-1272	162	12	;	;	PUNCT
admet-1272	162	13	structures	structure	NOUN
admet-1272	162	14	18	18	NUM
admet-1272	162	15	to	to	PART
admet-1272	162	16	24	24	NUM
admet-1272	162	17	admet	admet	PROPN
admet-1272	162	18	&	&	CCONJ
admet-1272	162	19	dmpk	dmpk	PROPN
admet-1272	162	20	10(2	10(2	NUM
admet-1272	162	21	)	)	PUNCT
admet-1272	162	22	(	(	PUNCT
admet-1272	162	23	2022	2022	NUM
admet-1272	162	24	)	)	PUNCT
admet-1272	162	25	131	131	NUM
admet-1272	162	26	-	-	SYM
admet-1272	162	27	146	146	NUM
admet-1272	162	28	chemical	chemical	NOUN
admet-1272	162	29	syntheses	synthesis	NOUN
admet-1272	162	30	and	and	CCONJ
admet-1272	162	31	resistant	resistant	ADJ
admet-1272	162	32	antibiotics	antibiotic	NOUN
admet-1272	162	33	doi	doi	NOUN
admet-1272	162	34	:	:	PUNCT
admet-1272	162	35	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	X
admet-1272	162	36	141	141	NUM
admet-1272	162	37	other	other	ADJ
admet-1272	162	38	peptide	peptide	NOUN
admet-1272	162	39	-	-	PUNCT
admet-1272	162	40	based	base	VERB
admet-1272	162	41	antibiotic	antibiotic	ADJ
admet-1272	162	42	classes	class	NOUN
admet-1272	162	43	with	with	ADP
admet-1272	162	44	potential	potential	ADJ
admet-1272	162	45	due	due	ADP
admet-1272	162	46	to	to	ADP
admet-1272	162	47	the	the	DET
admet-1272	162	48	ability	ability	NOUN
admet-1272	162	49	today	today	NOUN
admet-1272	162	50	to	to	PART
admet-1272	162	51	synthesize	synthesize	VERB
admet-1272	162	52	natural	natural	ADJ
admet-1272	162	53	-	-	PUNCT
admet-1272	162	54	product	product	NOUN
admet-1272	162	55	derived	derive	VERB
admet-1272	162	56	agents	agent	NOUN
admet-1272	162	57	,	,	PUNCT
admet-1272	162	58	particularly	particularly	ADV
admet-1272	162	59	peptidic	peptidic	ADJ
admet-1272	162	60	molecules	molecule	NOUN
admet-1272	162	61	under	under	ADP
admet-1272	162	62	glp	glp	PROPN
admet-1272	162	63	and	and	CCONJ
admet-1272	162	64	when	when	SCONJ
admet-1272	162	65	necessary	necessary	ADJ
admet-1272	162	66	,	,	PUNCT
admet-1272	162	67	cgmp	cgmp	PROPN
admet-1272	162	68	conditions	condition	NOUN
admet-1272	162	69	in	in	ADP
admet-1272	162	70	bulk	bulk	NOUN
admet-1272	162	71	,	,	PUNCT
admet-1272	162	72	once	once	ADV
admet-1272	162	73	a	a	DET
admet-1272	162	74	suitable	suitable	ADJ
admet-1272	162	75	compound	compound	NOUN
admet-1272	162	76	has	have	AUX
admet-1272	162	77	been	be	AUX
admet-1272	162	78	identified	identify	VERB
admet-1272	162	79	by	by	ADP
admet-1272	162	80	using	use	VERB
admet-1272	162	81	up	up	ADP
admet-1272	162	82	to	to	ADP
admet-1272	162	83	date	date	NOUN
admet-1272	162	84	versions	version	NOUN
admet-1272	162	85	of	of	ADP
admet-1272	162	86	the	the	DET
admet-1272	162	87	classical	classical	ADJ
admet-1272	162	88	searching	searching	NOUN
admet-1272	162	89	methods	method	NOUN
admet-1272	162	90	from	from	ADP
admet-1272	162	91	microbes	microbe	NOUN
admet-1272	162	92	,	,	PUNCT
admet-1272	162	93	they	they	PRON
admet-1272	162	94	can	can	AUX
admet-1272	162	95	be	be	AUX
admet-1272	162	96	synthesized	synthesize	VERB
admet-1272	162	97	and/or	and/or	CCONJ
admet-1272	162	98	modified	modify	VERB
admet-1272	162	99	as	as	SCONJ
admet-1272	162	100	needed	need	VERB
admet-1272	162	101	in	in	ADP
admet-1272	162	102	order	order	NOUN
admet-1272	162	103	to	to	PART
admet-1272	162	104	extend	extend	VERB
admet-1272	162	105	testing	testing	NOUN
admet-1272	162	106	schedules	schedule	NOUN
admet-1272	162	107	.	.	PUNCT
admet-1272	163	1	two	two	NUM
admet-1272	163	2	examples	example	NOUN
admet-1272	163	3	and	and	CCONJ
admet-1272	163	4	three	three	NUM
admet-1272	163	5	recent	recent	ADJ
admet-1272	163	6	reviews	review	NOUN
admet-1272	163	7	will	will	AUX
admet-1272	163	8	be	be	AUX
admet-1272	163	9	discussed	discuss	VERB
admet-1272	163	10	under	under	ADP
admet-1272	163	11	this	this	DET
admet-1272	163	12	rubric	rubric	NOUN
admet-1272	163	13	.	.	PUNCT
admet-1272	164	1	the	the	DET
admet-1272	164	2	first	first	ADJ
admet-1272	164	3	will	will	AUX
admet-1272	164	4	be	be	AUX
admet-1272	164	5	the	the	DET
admet-1272	164	6	material	material	NOUN
admet-1272	164	7	found	find	VERB
admet-1272	164	8	by	by	ADP
admet-1272	164	9	the	the	DET
admet-1272	164	10	lewis	lewis	PROPN
admet-1272	164	11	’	'	PUNCT
admet-1272	164	12	group	group	NOUN
admet-1272	164	13	at	at	ADP
admet-1272	164	14	northeastern	northeastern	ADJ
admet-1272	164	15	university	university	NOUN
admet-1272	164	16	,	,	PUNCT
admet-1272	164	17	and	and	CCONJ
admet-1272	164	18	the	the	DET
admet-1272	164	19	second	second	ADJ
admet-1272	164	20	will	will	AUX
admet-1272	164	21	be	be	AUX
admet-1272	164	22	what	what	PRON
admet-1272	164	23	i	i	PRON
admet-1272	164	24	call	call	VERB
admet-1272	164	25	the	the	DET
admet-1272	164	26	“	"	PUNCT
admet-1272	164	27	grasslands	grassland	NOUN
admet-1272	164	28	dna	dna	PROPN
admet-1272	164	29	program	program	NOUN
admet-1272	164	30	”	"	PUNCT
admet-1272	164	31	at	at	ADP
admet-1272	164	32	rockefeller	rockefeller	PROPN
admet-1272	164	33	university	university	PROPN
admet-1272	164	34	.	.	PUNCT
admet-1272	165	1	teixobactin	teixobactin	ADJ
admet-1272	165	2	in	in	ADP
admet-1272	165	3	2015	2015	NUM
admet-1272	165	4	,	,	PUNCT
admet-1272	165	5	the	the	DET
admet-1272	165	6	lewis	lewis	PROPN
admet-1272	165	7	group	group	PROPN
admet-1272	165	8	at	at	ADP
admet-1272	165	9	northeastern	northeastern	ADJ
admet-1272	165	10	university	university	PROPN
admet-1272	165	11	reported	report	VERB
admet-1272	165	12	the	the	DET
admet-1272	165	13	isolation	isolation	NOUN
admet-1272	165	14	of	of	ADP
admet-1272	165	15	a	a	DET
admet-1272	165	16	previously	previously	ADV
admet-1272	165	17	unknown	unknown	ADJ
admet-1272	165	18	microbe	microbe	NOUN
admet-1272	165	19	that	that	PRON
admet-1272	165	20	they	they	PRON
admet-1272	165	21	discovered	discover	VERB
admet-1272	165	22	by	by	ADP
admet-1272	165	23	use	use	NOUN
admet-1272	165	24	of	of	ADP
admet-1272	165	25	what	what	PRON
admet-1272	165	26	can	can	AUX
admet-1272	165	27	be	be	AUX
admet-1272	165	28	best	well	ADV
admet-1272	165	29	described	describe	VERB
admet-1272	165	30	as	as	ADP
admet-1272	165	31	a	a	DET
admet-1272	165	32	“	"	PUNCT
admet-1272	165	33	baiting	bait	VERB
admet-1272	165	34	technique	technique	NOUN
admet-1272	165	35	”	"	PUNCT
admet-1272	165	36	,	,	PUNCT
admet-1272	165	37	though	though	SCONJ
admet-1272	165	38	it	it	PRON
admet-1272	165	39	was	be	AUX
admet-1272	165	40	similar	similar	ADJ
admet-1272	165	41	in	in	ADP
admet-1272	165	42	concept	concept	NOUN
admet-1272	165	43	to	to	ADP
admet-1272	165	44	a	a	DET
admet-1272	165	45	technique	technique	NOUN
admet-1272	165	46	used	use	VERB
admet-1272	165	47	years	year	NOUN
admet-1272	165	48	earlier	early	ADV
admet-1272	165	49	by	by	ADP
admet-1272	165	50	a	a	DET
admet-1272	165	51	company	company	NOUN
admet-1272	165	52	named	name	VERB
admet-1272	165	53	“	"	PUNCT
admet-1272	165	54	one	one	NUM
admet-1272	165	55	-	-	PUNCT
admet-1272	165	56	drop	drop	NOUN
admet-1272	165	57	”	"	PUNCT
admet-1272	165	58	that	that	PRON
admet-1272	165	59	was	be	AUX
admet-1272	165	60	eventually	eventually	ADV
admet-1272	165	61	purchased	purchase	VERB
admet-1272	165	62	by	by	ADP
admet-1272	165	63	diversa	diversa	NOUN
admet-1272	165	64	,	,	PUNCT
admet-1272	165	65	though	though	SCONJ
admet-1272	165	66	details	detail	NOUN
admet-1272	165	67	were	be	AUX
admet-1272	165	68	lost	lose	VERB
admet-1272	165	69	when	when	SCONJ
admet-1272	165	70	diversa	diversa	PROPN
admet-1272	165	71	went	go	VERB
admet-1272	165	72	under	under	ADP
admet-1272	165	73	financially	financially	ADV
admet-1272	165	74	.	.	PUNCT
admet-1272	166	1	the	the	DET
admet-1272	166	2	compound	compound	NOUN
admet-1272	166	3	that	that	PRON
admet-1272	166	4	was	be	AUX
admet-1272	166	5	isolated	isolate	VERB
admet-1272	166	6	was	be	AUX
admet-1272	166	7	active	active	ADJ
admet-1272	166	8	against	against	ADP
admet-1272	166	9	multiply	multiply	ADV
admet-1272	166	10	resistant	resistant	ADJ
admet-1272	166	11	gram	gram	NOUN
admet-1272	166	12	-	-	PUNCT
admet-1272	166	13	positive	positive	ADJ
admet-1272	166	14	bacteria	bacteria	NOUN
admet-1272	166	15	,	,	PUNCT
admet-1272	166	16	and	and	CCONJ
admet-1272	166	17	it	it	PRON
admet-1272	166	18	was	be	AUX
admet-1272	166	19	found	find	VERB
admet-1272	166	20	to	to	PART
admet-1272	166	21	target	target	VERB
admet-1272	166	22	pyrophosphate	pyrophosphate	NOUN
admet-1272	166	23	and	and	CCONJ
admet-1272	166	24	sugar	sugar	NOUN
admet-1272	166	25	moieties	moiety	NOUN
admet-1272	166	26	present	present	ADJ
admet-1272	166	27	in	in	ADP
admet-1272	166	28	lipid	lipid	PROPN
admet-1272	166	29	ii	ii	PROPN
admet-1272	166	30	and	and	CCONJ
admet-1272	166	31	iii	iii	PROPN
admet-1272	166	32	.	.	PROPN
admet-1272	166	33	lipid	lipid	PROPN
admet-1272	166	34	ii	ii	PROPN
admet-1272	166	35	is	be	AUX
admet-1272	166	36	linked	link	VERB
admet-1272	166	37	to	to	ADP
admet-1272	166	38	peptidoglycan	peptidoglycan	PROPN
admet-1272	166	39	(	(	PUNCT
admet-1272	166	40	target	target	NOUN
admet-1272	166	41	of	of	ADP
admet-1272	166	42	the	the	DET
admet-1272	166	43	glycopeptide	glycopeptide	NOUN
admet-1272	166	44	antibiotics	antibiotic	NOUN
admet-1272	166	45	)	)	PUNCT
admet-1272	166	46	and	and	CCONJ
admet-1272	166	47	the	the	DET
admet-1272	166	48	lipid	lipid	NOUN
admet-1272	166	49	iii	iii	NOUN
admet-1272	166	50	binding	bind	VERB
admet-1272	166	51	is	be	AUX
admet-1272	166	52	linked	link	VERB
admet-1272	166	53	to	to	ADP
admet-1272	166	54	down	down	ADP
admet-1272	166	55	-	-	PUNCT
admet-1272	166	56	regulation	regulation	NOUN
admet-1272	166	57	of	of	ADP
admet-1272	166	58	cell	cell	NOUN
admet-1272	166	59	wall	wall	PROPN
admet-1272	166	60	teichoic	teichoic	PROPN
admet-1272	166	61	acid	acid	NOUN
admet-1272	166	62	biosynthesis	biosynthesis	NOUN
admet-1272	166	63	.	.	PUNCT
admet-1272	167	1	over	over	ADP
admet-1272	167	2	the	the	DET
admet-1272	167	3	last	last	ADJ
admet-1272	167	4	few	few	ADJ
admet-1272	167	5	years	year	NOUN
admet-1272	167	6	,	,	PUNCT
admet-1272	167	7	there	there	PRON
admet-1272	167	8	have	have	AUX
admet-1272	167	9	been	be	AUX
admet-1272	167	10	three	three	NUM
admet-1272	167	11	reports	report	NOUN
admet-1272	167	12	on	on	ADP
admet-1272	167	13	the	the	DET
admet-1272	167	14	total	total	ADJ
admet-1272	167	15	synthesis	synthesis	NOUN
admet-1272	167	16	of	of	ADP
admet-1272	167	17	this	this	DET
admet-1272	167	18	agent	agent	NOUN
admet-1272	167	19	,	,	PUNCT
admet-1272	167	20	plus	plus	CCONJ
admet-1272	167	21	several	several	ADJ
admet-1272	167	22	dozen	dozen	NOUN
admet-1272	167	23	reports	report	NOUN
admet-1272	167	24	covering	cover	VERB
admet-1272	167	25	analogues	analogue	NOUN
admet-1272	167	26	and	and	CCONJ
admet-1272	167	27	sar	sar	PROPN
admet-1272	167	28	studies	study	NOUN
admet-1272	167	29	as	as	SCONJ
admet-1272	167	30	shown	show	VERB
admet-1272	167	31	by	by	ADP
admet-1272	167	32	references	reference	NOUN
admet-1272	167	33	in	in	ADP
admet-1272	167	34	gao	gao	PROPN
admet-1272	167	35	et	et	PROPN
admet-1272	167	36	al	al	PROPN
admet-1272	167	37	.	.	PUNCT
admet-1272	168	1	[	[	X
admet-1272	168	2	38	38	NUM
admet-1272	168	3	]	]	PUNCT
admet-1272	168	4	,	,	PUNCT
admet-1272	168	5	all	all	PRON
admet-1272	168	6	using	use	VERB
admet-1272	168	7	solid	solid	ADJ
admet-1272	168	8	-	-	PUNCT
admet-1272	168	9	phase	phase	NOUN
admet-1272	168	10	techniques	technique	NOUN
admet-1272	168	11	.	.	PUNCT
admet-1272	169	1	in	in	ADP
admet-1272	169	2	2019	2019	NUM
admet-1272	169	3	,	,	PUNCT
admet-1272	169	4	gao	gao	PROPN
admet-1272	169	5	et	et	PROPN
admet-1272	169	6	al	al	PROPN
admet-1272	169	7	.	.	PROPN
admet-1272	169	8	published	publish	VERB
admet-1272	169	9	the	the	DET
admet-1272	169	10	first	first	ADJ
admet-1272	169	11	solution	solution	NOUN
admet-1272	169	12	-	-	PUNCT
admet-1272	169	13	phase	phase	NOUN
admet-1272	169	14	synthesis	synthesis	NOUN
admet-1272	169	15	,	,	PUNCT
admet-1272	169	16	thus	thus	ADV
admet-1272	169	17	adding	add	VERB
admet-1272	169	18	to	to	ADP
admet-1272	169	19	the	the	DET
admet-1272	169	20	synthetic	synthetic	ADJ
admet-1272	169	21	repertoire	repertoire	NOUN
admet-1272	169	22	for	for	ADP
admet-1272	169	23	this	this	DET
admet-1272	169	24	agent	agent	NOUN
admet-1272	169	25	and	and	CCONJ
admet-1272	169	26	the	the	DET
admet-1272	169	27	potential	potential	NOUN
admet-1272	169	28	for	for	ADP
admet-1272	169	29	many	many	ADJ
admet-1272	169	30	analogues	analogue	NOUN
admet-1272	169	31	[	[	X
admet-1272	169	32	38	38	NUM
admet-1272	169	33	]	]	PUNCT
admet-1272	169	34	.	.	PUNCT
admet-1272	170	1	thus	thus	ADV
admet-1272	170	2	there	there	PRON
admet-1272	170	3	are	be	VERB
admet-1272	170	4	at	at	ADV
admet-1272	170	5	least	least	ADJ
admet-1272	170	6	two	two	NUM
admet-1272	170	7	different	different	ADJ
admet-1272	170	8	routes	route	NOUN
admet-1272	170	9	to	to	ADP
admet-1272	170	10	the	the	DET
admet-1272	170	11	compound	compound	NOUN
admet-1272	170	12	and	and	CCONJ
admet-1272	170	13	derivatives	derivative	NOUN
admet-1272	170	14	.	.	PUNCT
admet-1272	171	1	an	an	DET
admet-1272	171	2	example	example	NOUN
admet-1272	171	3	of	of	ADP
admet-1272	171	4	modifying	modify	VERB
admet-1272	171	5	the	the	DET
admet-1272	171	6	agent	agent	NOUN
admet-1272	171	7	and	and	CCONJ
admet-1272	171	8	adding	add	VERB
admet-1272	171	9	activity	activity	NOUN
admet-1272	171	10	against	against	ADP
admet-1272	171	11	p.	p.	NOUN
admet-1272	171	12	aeruginosa	aeruginosa	PROPN
admet-1272	171	13	can	can	AUX
admet-1272	171	14	be	be	AUX
admet-1272	171	15	seen	see	VERB
admet-1272	171	16	in	in	ADP
admet-1272	171	17	the	the	DET
admet-1272	171	18	report	report	NOUN
admet-1272	171	19	by	by	ADP
admet-1272	171	20	ng	ng	PROPN
admet-1272	171	21	et	et	PROPN
admet-1272	171	22	al	al	PROPN
admet-1272	171	23	.	.	PROPN
admet-1272	172	1	in	in	ADP
admet-1272	172	2	2018	2018	NUM
admet-1272	172	3	[	[	X
admet-1272	172	4	39	39	NUM
admet-1272	172	5	]	]	PUNCT
admet-1272	172	6	.	.	PUNCT
admet-1272	173	1	grasslands	grassland	NOUN
admet-1272	173	2	dna	dna	PROPN
admet-1272	173	3	in	in	ADP
admet-1272	173	4	2014	2014	NUM
admet-1272	173	5	,	,	PUNCT
admet-1272	173	6	the	the	DET
admet-1272	173	7	brady	brady	PROPN
admet-1272	173	8	group	group	PROPN
admet-1272	173	9	at	at	ADP
admet-1272	173	10	rockefeller	rockefeller	PROPN
admet-1272	173	11	published	publish	VERB
admet-1272	173	12	an	an	DET
admet-1272	173	13	article	article	NOUN
admet-1272	173	14	in	in	ADP
admet-1272	173	15	current	current	ADJ
admet-1272	173	16	opinion	opinion	NOUN
admet-1272	173	17	in	in	ADP
admet-1272	173	18	microbiology	microbiology	NOUN
admet-1272	173	19	describing	describe	VERB
admet-1272	173	20	the	the	DET
admet-1272	173	21	varied	varied	ADJ
admet-1272	173	22	then	then	ADV
admet-1272	173	23	current	current	ADJ
admet-1272	173	24	methods	method	NOUN
admet-1272	173	25	that	that	PRON
admet-1272	173	26	used	use	VERB
admet-1272	173	27	metagenomic	metagenomic	ADJ
admet-1272	173	28	studies	study	NOUN
admet-1272	173	29	to	to	PART
admet-1272	173	30	obtain	obtain	VERB
admet-1272	173	31	potential	potential	ADJ
admet-1272	173	32	antibiotic	antibiotic	ADJ
admet-1272	173	33	information	information	NOUN
admet-1272	173	34	without	without	ADP
admet-1272	173	35	isolating	isolate	VERB
admet-1272	173	36	the	the	DET
admet-1272	173	37	microbe(s	microbe(s	NOUN
admet-1272	173	38	)	)	PUNCT
admet-1272	174	1	[	[	X
admet-1272	174	2	40	40	NUM
admet-1272	174	3	]	]	PUNCT
admet-1272	174	4	.	.	PUNCT
admet-1272	175	1	in	in	ADP
admet-1272	175	2	2015	2015	NUM
admet-1272	175	3	charlop	charlop	NOUN
admet-1272	175	4	-	-	PUNCT
admet-1272	175	5	powers	power	NOUN
admet-1272	175	6	and	and	CCONJ
admet-1272	175	7	brady	brady	PROPN
admet-1272	175	8	published	publish	VERB
admet-1272	175	9	an	an	DET
admet-1272	175	10	informatic	informatic	ADJ
admet-1272	175	11	package	package	NOUN
admet-1272	175	12	that	that	PRON
admet-1272	175	13	linked	link	VERB
admet-1272	175	14	geographic	geographic	ADJ
admet-1272	175	15	analysis	analysis	NOUN
admet-1272	175	16	and	and	CCONJ
admet-1272	175	17	related	relate	VERB
admet-1272	175	18	microbiome	microbiome	ADJ
admet-1272	175	19	data	datum	NOUN
admet-1272	175	20	[	[	X
admet-1272	175	21	41	41	NUM
admet-1272	175	22	]	]	PUNCT
admet-1272	175	23	.	.	PUNCT
admet-1272	176	1	following	follow	VERB
admet-1272	176	2	on	on	ADP
admet-1272	176	3	,	,	PUNCT
admet-1272	176	4	in	in	ADP
admet-1272	176	5	2016	2016	NUM
admet-1272	176	6	,	,	PUNCT
admet-1272	176	7	the	the	DET
admet-1272	176	8	group	group	NOUN
admet-1272	176	9	published	publish	VERB
admet-1272	176	10	their	their	PRON
admet-1272	176	11	initial	initial	ADJ
admet-1272	176	12	data	datum	NOUN
admet-1272	176	13	on	on	ADP
admet-1272	176	14	“	"	PUNCT
admet-1272	176	15	urban	urban	PROPN
admet-1272	176	16	park	park	NOUN
admet-1272	176	17	microbiomes	microbiomes	PROPN
admet-1272	176	18	”	"	PUNCT
admet-1272	176	19	as	as	ADP
admet-1272	176	20	sources	source	NOUN
admet-1272	176	21	of	of	ADP
admet-1272	176	22	biosynthetic	biosynthetic	ADJ
admet-1272	176	23	diversity	diversity	NOUN
admet-1272	176	24	(	(	PUNCT
admet-1272	176	25	hence	hence	ADV
admet-1272	176	26	the	the	DET
admet-1272	176	27	title	title	NOUN
admet-1272	176	28	for	for	ADP
admet-1272	176	29	this	this	DET
admet-1272	176	30	section	section	NOUN
admet-1272	176	31	)	)	PUNCT
admet-1272	177	1	[	[	X
admet-1272	177	2	42	42	NUM
admet-1272	177	3	]	]	PUNCT
admet-1272	177	4	.	.	PUNCT
admet-1272	178	1	in	in	ADP
admet-1272	178	2	this	this	DET
admet-1272	178	3	work	work	NOUN
admet-1272	178	4	,	,	PUNCT
admet-1272	178	5	they	they	PRON
admet-1272	178	6	reported	report	VERB
admet-1272	178	7	a	a	DET
admet-1272	178	8	gene	gene	NOUN
admet-1272	178	9	cluster	cluster	NOUN
admet-1272	178	10	that	that	PRON
admet-1272	178	11	could	could	AUX
admet-1272	178	12	be	be	AUX
admet-1272	178	13	linked	link	VERB
admet-1272	178	14	to	to	ADP
admet-1272	178	15	a	a	DET
admet-1272	178	16	novel	novel	ADJ
admet-1272	178	17	calcium	calcium	NOUN
admet-1272	178	18	-	-	PUNCT
admet-1272	178	19	dependent	dependent	ADJ
admet-1272	178	20	antibiotic	antibiotic	ADJ
admet-1272	178	21	(	(	PUNCT
admet-1272	178	22	cda	cda	PROPN
admet-1272	178	23	)	)	PUNCT
admet-1272	178	24	.	.	PUNCT
admet-1272	179	1	in	in	ADP
admet-1272	179	2	2018	2018	NUM
admet-1272	179	3	they	they	PRON
admet-1272	179	4	reported	report	VERB
admet-1272	179	5	on	on	ADP
admet-1272	179	6	the	the	DET
admet-1272	179	7	culture	culture	NOUN
admet-1272	179	8	-	-	PUNCT
admet-1272	179	9	independent	independent	ADJ
admet-1272	179	10	synthetic	synthetic	ADJ
admet-1272	179	11	-	-	PUNCT
admet-1272	179	12	bioinformatic	bioinformatic	ADJ
admet-1272	179	13	natural	natural	ADJ
admet-1272	179	14	product	product	NOUN
admet-1272	179	15	(	(	PUNCT
admet-1272	179	16	syn	syn	PROPN
admet-1272	179	17	-	-	PUNCT
admet-1272	179	18	bnp	bnp	PROPN
admet-1272	179	19	)	)	PUNCT
admet-1272	179	20	discovery	discovery	NOUN
admet-1272	179	21	approach	approach	NOUN
admet-1272	179	22	covering	cover	VERB
admet-1272	179	23	the	the	DET
admet-1272	179	24	survey	survey	NOUN
admet-1272	179	25	of	of	ADP
admet-1272	179	26	analogues	analogue	NOUN
admet-1272	179	27	of	of	ADP
admet-1272	179	28	paenimucillin	paenimucillin	PROPN
admet-1272	179	29	a	a	PRON
admet-1272	179	30	(	(	PUNCT
admet-1272	179	31	23	23	NUM
admet-1272	179	32	)	)	PUNCT
admet-1272	179	33	that	that	PRON
admet-1272	179	34	led	lead	VERB
admet-1272	179	35	to	to	ADP
admet-1272	179	36	the	the	DET
admet-1272	179	37	discovery	discovery	NOUN
admet-1272	179	38	of	of	ADP
admet-1272	179	39	paenimucillin	paenimucillin	PROPN
admet-1272	179	40	c	c	PROPN
admet-1272	179	41	(	(	PUNCT
admet-1272	179	42	24	24	NUM
admet-1272	179	43	)	)	PUNCT
admet-1272	179	44	which	which	PRON
admet-1272	179	45	inhibited	inhibit	VERB
admet-1272	179	46	the	the	DET
admet-1272	179	47	growth	growth	NOUN
admet-1272	179	48	of	of	ADP
admet-1272	179	49	multidrug	multidrug	NOUN
admet-1272	179	50	-	-	PUNCT
admet-1272	179	51	resistant	resistant	ADJ
admet-1272	179	52	a.	a.	NOUN
admet-1272	179	53	baumannii	baumannii	ADJ
admet-1272	179	54	isolates	isolate	NOUN
admet-1272	179	55	,	,	PUNCT
admet-1272	179	56	including	include	VERB
admet-1272	179	57	a	a	DET
admet-1272	179	58	rat	rat	NOUN
admet-1272	179	59	cutaneous	cutaneous	ADJ
admet-1272	179	60	wound	wound	NOUN
admet-1272	179	61	model	model	NOUN
admet-1272	179	62	,	,	PUNCT
admet-1272	179	63	with	with	ADP
admet-1272	179	64	mechanistic	mechanistic	ADJ
admet-1272	179	65	studies	study	NOUN
admet-1272	179	66	implying	imply	VERB
admet-1272	179	67	a	a	DET
admet-1272	179	68	membrane	membrane	NOUN
admet-1272	179	69	-	-	PUNCT
admet-1272	179	70	associated	associate	VERB
admet-1272	179	71	mode	mode	NOUN
admet-1272	179	72	of	of	ADP
admet-1272	179	73	action	action	NOUN
admet-1272	179	74	[	[	X
admet-1272	179	75	43	43	NUM
admet-1272	179	76	]	]	PUNCT
admet-1272	179	77	.	.	PUNCT
admet-1272	180	1	in	in	ADP
admet-1272	180	2	2020	2020	NUM
admet-1272	180	3	this	this	DET
admet-1272	180	4	report	report	NOUN
admet-1272	180	5	was	be	AUX
admet-1272	180	6	expanded	expand	VERB
admet-1272	180	7	by	by	ADP
admet-1272	180	8	the	the	DET
admet-1272	180	9	same	same	ADJ
admet-1272	180	10	group	group	NOUN
admet-1272	180	11	giving	give	VERB
admet-1272	180	12	details	detail	NOUN
admet-1272	180	13	of	of	ADP
admet-1272	180	14	the	the	DET
admet-1272	180	15	synthesis	synthesis	NOUN
admet-1272	180	16	of	of	ADP
admet-1272	180	17	157	157	NUM
admet-1272	180	18	cyclic	cyclic	ADJ
admet-1272	180	19	peptides	peptide	NOUN
admet-1272	180	20	from	from	ADP
admet-1272	180	21	96	96	NUM
admet-1272	180	22	nrps	nrps	NOUN
admet-1272	180	23	clusters	cluster	NOUN
admet-1272	180	24	.	.	PUNCT
admet-1272	181	1	these	these	DET
admet-1272	181	2	compounds	compound	NOUN
admet-1272	181	3	were	be	AUX
admet-1272	181	4	then	then	ADV
admet-1272	181	5	tested	test	VERB
admet-1272	181	6	against	against	ADP
admet-1272	181	7	the	the	DET
admet-1272	181	8	eskape	eskape	NOUN
admet-1272	181	9	pathogens	pathogen	NOUN
admet-1272	181	10	yielding	yield	VERB
admet-1272	181	11	nine	nine	NUM
admet-1272	181	12	antibiotics	antibiotic	NOUN
admet-1272	181	13	with	with	ADP
admet-1272	181	14	activities	activity	NOUN
admet-1272	181	15	against	against	ADP
admet-1272	181	16	some	some	PRON
admet-1272	181	17	of	of	ADP
admet-1272	181	18	these	these	DET
admet-1272	181	19	microbes	microbe	NOUN
admet-1272	181	20	as	as	ADV
admet-1272	181	21	well	well	ADV
admet-1272	181	22	as	as	ADP
admet-1272	181	23	m.	m.	NOUN
admet-1272	181	24	tuberculosis	tuberculosis	NOUN
admet-1272	182	1	[	[	X
admet-1272	183	1	44	44	NUM
admet-1272	183	2	]	]	PUNCT
admet-1272	183	3	.	.	PUNCT
admet-1272	184	1	that	that	DET
admet-1272	184	2	same	same	ADJ
admet-1272	184	3	year	year	NOUN
admet-1272	184	4	,	,	PUNCT
admet-1272	184	5	the	the	DET
admet-1272	184	6	group	group	NOUN
admet-1272	184	7	reported	report	VERB
admet-1272	184	8	on	on	ADP
admet-1272	184	9	the	the	DET
admet-1272	184	10	culture	culture	NOUN
admet-1272	184	11	-	-	PUNCT
admet-1272	184	12	independent	independent	ADJ
admet-1272	184	13	discovery	discovery	NOUN
admet-1272	184	14	of	of	ADP
admet-1272	184	15	the	the	DET
admet-1272	184	16	cda	cda	PROPN
admet-1272	184	17	compound	compound	PROPN
admet-1272	184	18	referred	refer	VERB
admet-1272	184	19	to	to	ADP
admet-1272	184	20	in	in	ADP
admet-1272	184	21	their	their	PRON
admet-1272	184	22	earlier	early	ADJ
admet-1272	184	23	general	general	ADJ
admet-1272	184	24	paper	paper	NOUN
admet-1272	184	25	in	in	ADP
admet-1272	184	26	2016	2016	NUM
admet-1272	184	27	,	,	PUNCT
admet-1272	184	28	demonstrating	demonstrate	VERB
admet-1272	184	29	excellent	excellent	ADJ
admet-1272	184	30	activities	activity	NOUN
admet-1272	184	31	(	(	PUNCT
admet-1272	184	32	mic	mic	ADJ
admet-1272	184	33	values	value	NOUN
admet-1272	184	34	between	between	ADP
admet-1272	184	35	0.1	0.1	NUM
admet-1272	184	36	to	to	PART
admet-1272	184	37	0.8	0.8	NUM
admet-1272	184	38	µg	µg	ADV
admet-1272	184	39	ml-1	ml-1	X
admet-1272	184	40	)	)	PUNCT
admet-1272	184	41	for	for	ADP
admet-1272	184	42	malacidin	malacidin	VERB
admet-1272	184	43	a	a	DET
admet-1272	184	44	(	(	PUNCT
admet-1272	184	45	25	25	NUM
admet-1272	184	46	)	)	PUNCT
admet-1272	184	47	depending	depend	VERB
admet-1272	184	48	upon	upon	SCONJ
admet-1272	184	49	the	the	DET
admet-1272	184	50	particular	particular	ADJ
admet-1272	184	51	resistant	resistant	ADJ
admet-1272	184	52	organism	organism	NOUN
admet-1272	184	53	tested	test	VERB
admet-1272	184	54	.	.	PUNCT
admet-1272	185	1	these	these	PRON
admet-1272	185	2	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	X
admet-1272	185	3	david	david	PROPN
admet-1272	185	4	j.	j.	PROPN
admet-1272	185	5	newman	newman	PROPN
admet-1272	185	6	admet	admet	PROPN
admet-1272	185	7	&	&	CCONJ
admet-1272	185	8	dmpk	dmpk	PROPN
admet-1272	185	9	10(2	10(2	NUM
admet-1272	185	10	)	)	PUNCT
admet-1272	185	11	(	(	PUNCT
admet-1272	185	12	2022	2022	NUM
admet-1272	185	13	)	)	PUNCT
admet-1272	185	14	131	131	NUM
admet-1272	185	15	-	-	SYM
admet-1272	185	16	146	146	NUM
admet-1272	185	17	142	142	NUM
admet-1272	185	18	included	include	VERB
admet-1272	185	19	microbes	microbe	NOUN
admet-1272	185	20	resistant	resistant	ADJ
admet-1272	185	21	to	to	ADP
admet-1272	185	22	β	β	NOUN
admet-1272	185	23	-	-	NOUN
admet-1272	185	24	lactams	lactam	NOUN
admet-1272	185	25	,	,	PUNCT
admet-1272	185	26	tetracyclines	tetracycline	NOUN
admet-1272	185	27	,	,	PUNCT
admet-1272	185	28	vancomycin	vancomycin	PROPN
admet-1272	185	29	and	and	CCONJ
admet-1272	185	30	aminoglycosides	aminoglycoside	NOUN
admet-1272	185	31	.	.	PUNCT
admet-1272	186	1	the	the	DET
admet-1272	186	2	other	other	PROPN
admet-1272	186	3	cda	cda	PROPN
admet-1272	186	4	that	that	SCONJ
admet-1272	186	5	they	they	PRON
admet-1272	186	6	reported	report	VERB
admet-1272	186	7	,	,	PUNCT
admet-1272	186	8	malacidin	malacidin	NOUN
admet-1272	186	9	b	b	PROPN
admet-1272	186	10	(	(	PUNCT
admet-1272	186	11	26	26	NUM
admet-1272	186	12	)	)	PUNCT
admet-1272	186	13	,	,	PUNCT
admet-1272	186	14	differs	differ	VERB
admet-1272	186	15	by	by	ADP
admet-1272	186	16	one	one	NUM
admet-1272	186	17	methylene	methylene	NOUN
admet-1272	186	18	group	group	NOUN
admet-1272	186	19	from	from	ADP
admet-1272	186	20	malacidin	malacidin	VERB
admet-1272	186	21	a	a	PRON
admet-1272	186	22	[	[	X
admet-1272	186	23	45	45	NUM
admet-1272	186	24	]	]	PUNCT
admet-1272	186	25	.	.	PUNCT
admet-1272	187	1	this	this	DET
admet-1272	187	2	paper	paper	NOUN
admet-1272	187	3	has	have	VERB
admet-1272	187	4	over	over	ADP
admet-1272	187	5	180	180	NUM
admet-1272	187	6	citations	citation	NOUN
admet-1272	187	7	in	in	ADP
admet-1272	187	8	scopus	scopus	NOUN
admet-1272	187	9	as	as	ADP
admet-1272	187	10	of	of	ADP
admet-1272	187	11	the	the	DET
admet-1272	187	12	middle	middle	NOUN
admet-1272	187	13	of	of	ADP
admet-1272	187	14	january	january	PROPN
admet-1272	187	15	2022	2022	NUM
admet-1272	187	16	.	.	PUNCT
admet-1272	188	1	then	then	ADV
admet-1272	188	2	in	in	ADP
admet-1272	188	3	2020	2020	NUM
admet-1272	188	4	,	,	PUNCT
admet-1272	188	5	the	the	DET
admet-1272	188	6	complete	complete	ADJ
admet-1272	188	7	synthesis	synthesis	NOUN
admet-1272	188	8	of	of	ADP
admet-1272	188	9	malacidin	malacidin	NOUN
admet-1272	188	10	a	a	PRON
admet-1272	188	11	was	be	AUX
admet-1272	188	12	published	publish	VERB
admet-1272	188	13	by	by	ADP
admet-1272	188	14	a	a	DET
admet-1272	188	15	joint	joint	ADJ
admet-1272	188	16	group	group	NOUN
admet-1272	188	17	from	from	ADP
admet-1272	188	18	the	the	DET
admet-1272	188	19	university	university	NOUN
admet-1272	188	20	of	of	ADP
admet-1272	188	21	hong	hong	PROPN
admet-1272	188	22	kong	kong	PROPN
admet-1272	188	23	and	and	CCONJ
admet-1272	188	24	rockefeller	rockefeller	NOUN
admet-1272	189	1	[	[	X
admet-1272	189	2	46	46	NUM
admet-1272	189	3	]	]	PUNCT
admet-1272	189	4	.	.	PUNCT
admet-1272	190	1	as	as	ADP
admet-1272	190	2	a	a	DET
admet-1272	190	3	result	result	NOUN
admet-1272	190	4	of	of	ADP
admet-1272	190	5	the	the	DET
admet-1272	190	6	malacidin	malacidin	NOUN
admet-1272	190	7	findings	finding	NOUN
admet-1272	190	8	,	,	PUNCT
admet-1272	190	9	a	a	DET
admet-1272	190	10	second	second	ADJ
admet-1272	190	11	total	total	ADJ
admet-1272	190	12	synthesis	synthesis	NOUN
admet-1272	190	13	of	of	ADP
admet-1272	190	14	malacidin	malacidin	NOUN
admet-1272	190	15	a	a	PRON
admet-1272	190	16	and	and	CCONJ
admet-1272	190	17	analogues	analogue	NOUN
admet-1272	190	18	was	be	AUX
admet-1272	190	19	recently	recently	ADV
admet-1272	190	20	published	publish	VERB
admet-1272	190	21	by	by	ADP
admet-1272	190	22	the	the	DET
admet-1272	190	23	brimble	brimble	ADJ
admet-1272	190	24	group	group	NOUN
admet-1272	190	25	in	in	ADP
admet-1272	190	26	new	new	PROPN
admet-1272	190	27	zealand	zealand	PROPN
admet-1272	191	1	[	[	X
admet-1272	191	2	47	47	NUM
admet-1272	191	3	]	]	PUNCT
admet-1272	191	4	.	.	PUNCT
admet-1272	192	1	three	three	NUM
admet-1272	192	2	recent	recent	ADJ
admet-1272	192	3	reviews	review	NOUN
admet-1272	192	4	on	on	ADP
admet-1272	192	5	other	other	ADJ
admet-1272	192	6	peptidic	peptidic	ADJ
admet-1272	192	7	antibiotics	antibiotic	NOUN
admet-1272	192	8	in	in	ADP
admet-1272	192	9	2021	2021	NUM
admet-1272	192	10	,	,	PUNCT
admet-1272	192	11	two	two	NUM
admet-1272	192	12	interesting	interesting	ADJ
admet-1272	192	13	reviews	review	NOUN
admet-1272	192	14	on	on	ADP
admet-1272	192	15	peptidic	peptidic	ADJ
admet-1272	192	16	antibiotics	antibiotic	NOUN
admet-1272	192	17	were	be	AUX
admet-1272	192	18	published	publish	VERB
admet-1272	192	19	,	,	PUNCT
admet-1272	192	20	with	with	ADP
admet-1272	192	21	a	a	DET
admet-1272	192	22	third	third	NOUN
admet-1272	192	23	in	in	ADP
admet-1272	192	24	2022	2022	NUM
admet-1272	192	25	.	.	PUNCT
admet-1272	193	1	the	the	DET
admet-1272	193	2	first	first	ADJ
admet-1272	193	3	in	in	ADP
admet-1272	193	4	2021	2021	NUM
admet-1272	193	5	discussed	discuss	VERB
admet-1272	193	6	emerging	emerge	VERB
admet-1272	193	7	peptides	peptide	NOUN
admet-1272	193	8	with	with	ADP
admet-1272	193	9	therapeutic	therapeutic	ADJ
admet-1272	193	10	potential	potential	NOUN
admet-1272	193	11	,	,	PUNCT
admet-1272	193	12	with	with	ADP
admet-1272	193	13	one	one	NUM
admet-1272	193	14	author	author	NOUN
admet-1272	193	15	from	from	ADP
admet-1272	193	16	the	the	DET
admet-1272	193	17	biotech	biotech	ADJ
admet-1272	193	18	company	company	NOUN
admet-1272	193	19	polyphor	polyphor	NOUN
admet-1272	193	20	in	in	ADP
admet-1272	193	21	switzerland	switzerland	PROPN
admet-1272	193	22	,	,	PUNCT
admet-1272	193	23	which	which	PRON
admet-1272	193	24	has	have	AUX
admet-1272	193	25	been	be	AUX
admet-1272	193	26	involved	involve	VERB
admet-1272	193	27	in	in	ADP
admet-1272	193	28	clinical	clinical	ADJ
admet-1272	193	29	trials	trial	NOUN
admet-1272	193	30	with	with	ADP
admet-1272	193	31	such	such	ADJ
admet-1272	193	32	agents	agent	NOUN
admet-1272	193	33	,	,	PUNCT
admet-1272	193	34	demonstrating	demonstrate	VERB
admet-1272	193	35	the	the	DET
admet-1272	193	36	variation	variation	NOUN
admet-1272	193	37	in	in	ADP
admet-1272	193	38	linear	linear	ADJ
admet-1272	193	39	and	and	CCONJ
admet-1272	193	40	cyclic	cyclic	ADJ
admet-1272	193	41	peptides	peptide	NOUN
admet-1272	193	42	with	with	ADP
admet-1272	193	43	significant	significant	ADJ
admet-1272	193	44	bioactivities	bioactivitie	NOUN
admet-1272	193	45	against	against	ADP
admet-1272	193	46	resistant	resistant	ADJ
admet-1272	193	47	microbes	microbe	NOUN
admet-1272	193	48	[	[	X
admet-1272	193	49	48	48	NUM
admet-1272	193	50	]	]	PUNCT
admet-1272	193	51	.	.	PUNCT
admet-1272	194	1	the	the	DET
admet-1272	194	2	second	second	ADJ
admet-1272	194	3	in	in	ADP
admet-1272	194	4	2021	2021	NUM
admet-1272	194	5	,	,	PUNCT
admet-1272	194	6	was	be	AUX
admet-1272	194	7	from	from	ADP
admet-1272	194	8	a	a	DET
admet-1272	194	9	group	group	NOUN
admet-1272	194	10	in	in	ADP
admet-1272	194	11	china	china	PROPN
admet-1272	194	12	and	and	CCONJ
admet-1272	194	13	an	an	DET
admet-1272	194	14	interesting	interesting	ADJ
admet-1272	194	15	part	part	NOUN
admet-1272	194	16	of	of	ADP
admet-1272	194	17	that	that	DET
admet-1272	194	18	review	review	NOUN
admet-1272	194	19	is	be	AUX
admet-1272	194	20	a	a	DET
admet-1272	194	21	long	long	ADJ
admet-1272	194	22	table	table	NOUN
admet-1272	194	23	listing	list	VERB
admet-1272	194	24	natural	natural	ADJ
admet-1272	194	25	,	,	PUNCT
admet-1272	194	26	semisynthetic	semisynthetic	ADJ
admet-1272	194	27	and	and	CCONJ
admet-1272	194	28	synthetic	synthetic	ADJ
admet-1272	194	29	agents	agent	NOUN
admet-1272	194	30	reported	report	VERB
admet-1272	194	31	in	in	ADP
admet-1272	194	32	the	the	DET
admet-1272	194	33	last	last	ADJ
admet-1272	194	34	five	five	NUM
admet-1272	194	35	years	year	NOUN
admet-1272	194	36	.	.	PUNCT
admet-1272	195	1	that	that	DET
admet-1272	195	2	table	table	NOUN
admet-1272	195	3	makes	make	VERB
admet-1272	195	4	interesting	interesting	ADJ
admet-1272	195	5	reading	reading	NOUN
admet-1272	195	6	,	,	PUNCT
admet-1272	195	7	as	as	SCONJ
admet-1272	195	8	it	it	PRON
admet-1272	195	9	aptly	aptly	ADV
admet-1272	195	10	demonstrates	demonstrate	VERB
admet-1272	195	11	what	what	PRON
admet-1272	195	12	can	can	AUX
admet-1272	195	13	be	be	AUX
admet-1272	195	14	done	do	VERB
admet-1272	195	15	with	with	ADP
admet-1272	195	16	current	current	ADJ
admet-1272	195	17	synthetic	synthetic	ADJ
admet-1272	195	18	methods	method	NOUN
admet-1272	195	19	[	[	X
admet-1272	195	20	49	49	NUM
admet-1272	195	21	]	]	PUNCT
admet-1272	195	22	.	.	PUNCT
admet-1272	196	1	the	the	DET
admet-1272	196	2	third	third	ADJ
admet-1272	196	3	,	,	PUNCT
admet-1272	196	4	accepted	accept	VERB
admet-1272	196	5	at	at	ADP
admet-1272	196	6	the	the	DET
admet-1272	196	7	very	very	ADJ
admet-1272	196	8	end	end	NOUN
admet-1272	196	9	of	of	ADP
admet-1272	196	10	december	december	PROPN
admet-1272	196	11	2021	2021	NUM
admet-1272	196	12	and	and	CCONJ
admet-1272	196	13	currently	currently	ADV
admet-1272	196	14	online	online	ADJ
admet-1272	196	15	,	,	PUNCT
admet-1272	196	16	is	be	AUX
admet-1272	196	17	full	full	ADJ
admet-1272	196	18	of	of	ADP
admet-1272	196	19	up	up	ADP
admet-1272	196	20	to	to	ADP
admet-1272	196	21	date	date	NOUN
admet-1272	196	22	listings	listing	NOUN
admet-1272	196	23	of	of	ADP
admet-1272	196	24	agents	agent	NOUN
admet-1272	196	25	,	,	PUNCT
admet-1272	196	26	sources	source	NOUN
admet-1272	196	27	,	,	PUNCT
admet-1272	196	28	and	and	CCONJ
admet-1272	196	29	clinical	clinical	ADJ
admet-1272	196	30	trial	trial	NOUN
admet-1272	196	31	results	result	NOUN
admet-1272	196	32	,	,	PUNCT
admet-1272	196	33	plus	plus	CCONJ
admet-1272	196	34	discussions	discussion	NOUN
admet-1272	196	35	as	as	ADP
admet-1272	196	36	to	to	PART
admet-1272	196	37	probable	probable	ADJ
admet-1272	196	38	and	and	CCONJ
admet-1272	196	39	actual	actual	ADJ
admet-1272	196	40	mechanisms	mechanism	NOUN
admet-1272	196	41	of	of	ADP
admet-1272	196	42	action	action	NOUN
admet-1272	196	43	[	[	X
admet-1272	196	44	50	50	NUM
admet-1272	196	45	]	]	PUNCT
admet-1272	196	46	.	.	PUNCT
admet-1272	197	1	conclusion	conclusion	NOUN
admet-1272	197	2	synthetic	synthetic	NOUN
admet-1272	197	3	chemists	chemist	NOUN
admet-1272	197	4	have	have	AUX
admet-1272	197	5	now	now	ADV
admet-1272	197	6	shown	show	VERB
admet-1272	197	7	that	that	SCONJ
admet-1272	197	8	they	they	PRON
admet-1272	197	9	can	can	AUX
admet-1272	197	10	modify	modify	VERB
admet-1272	197	11	natural	natural	ADJ
admet-1272	197	12	product	product	NOUN
admet-1272	197	13	-	-	PUNCT
admet-1272	197	14	based	base	VERB
admet-1272	197	15	antibiotics	antibiotic	NOUN
admet-1272	197	16	that	that	PRON
admet-1272	197	17	have	have	AUX
admet-1272	197	18	ceased	cease	VERB
admet-1272	197	19	to	to	PART
admet-1272	197	20	be	be	AUX
admet-1272	197	21	viable	viable	ADJ
admet-1272	197	22	due	due	ADP
admet-1272	197	23	to	to	ADP
admet-1272	197	24	the	the	DET
admet-1272	197	25	build	build	NOUN
admet-1272	197	26	-	-	PUNCT
admet-1272	197	27	up	up	NOUN
admet-1272	197	28	of	of	ADP
admet-1272	197	29	multiple	multiple	ADJ
admet-1272	197	30	resistance	resistance	NOUN
admet-1272	197	31	profiles	profile	NOUN
admet-1272	197	32	.	.	PUNCT
admet-1272	198	1	as	as	ADP
admet-1272	198	2	an	an	DET
admet-1272	198	3	example	example	NOUN
admet-1272	198	4	of	of	ADP
admet-1272	198	5	what	what	PRON
admet-1272	198	6	can	can	AUX
admet-1272	198	7	be	be	AUX
admet-1272	198	8	done	do	VERB
admet-1272	198	9	today	today	NOUN
admet-1272	198	10	by	by	ADP
admet-1272	198	11	competent	competent	ADJ
admet-1272	198	12	synthetic	synthetic	ADJ
admet-1272	198	13	chemists	chemist	NOUN
admet-1272	198	14	,	,	PUNCT
admet-1272	198	15	the	the	DET
admet-1272	198	16	recent	recent	ADJ
admet-1272	198	17	review	review	NOUN
admet-1272	198	18	by	by	ADP
admet-1272	198	19	nicolaou	nicolaou	PROPN
admet-1272	198	20	and	and	CCONJ
admet-1272	198	21	rigel	rigel	PROPN
admet-1272	198	22	shows	show	VERB
admet-1272	198	23	some	some	PRON
admet-1272	198	24	of	of	ADP
admet-1272	198	25	the	the	DET
admet-1272	198	26	capabilities	capability	NOUN
admet-1272	198	27	of	of	ADP
admet-1272	198	28	experts	expert	NOUN
admet-1272	198	29	in	in	ADP
admet-1272	198	30	this	this	DET
admet-1272	198	31	field	field	NOUN
admet-1272	198	32	[	[	X
admet-1272	198	33	51	51	NUM
admet-1272	198	34	]	]	PUNCT
admet-1272	198	35	.	.	PUNCT
admet-1272	199	1	to	to	ADP
admet-1272	199	2	this	this	DET
admet-1272	199	3	review	review	NOUN
admet-1272	199	4	can	can	AUX
admet-1272	199	5	be	be	AUX
admet-1272	199	6	added	add	VERB
admet-1272	199	7	the	the	DET
admet-1272	199	8	work	work	NOUN
admet-1272	199	9	referred	refer	VERB
admet-1272	199	10	to	to	ADP
admet-1272	199	11	earlier	early	ADV
admet-1272	199	12	on	on	ADP
admet-1272	199	13	the	the	DET
admet-1272	199	14	total	total	ADJ
admet-1272	199	15	synthesis	synthesis	NOUN
admet-1272	199	16	of	of	ADP
admet-1272	199	17	a	a	DET
admet-1272	199	18	derivative	derivative	NOUN
admet-1272	199	19	of	of	ADP
admet-1272	199	20	halichondrin	halichondrin	NOUN
admet-1272	199	21	b	b	PROPN
admet-1272	199	22	e7130	e7130	ADJ
admet-1272	199	23	(	(	PUNCT
admet-1272	199	24	mw	mw	PROPN
admet-1272	199	25	1111	1111	NUM
admet-1272	199	26	,	,	PUNCT
admet-1272	199	27	6	6	NUM
admet-1272	199	28	)	)	PUNCT
admet-1272	199	29	producing	produce	VERB
admet-1272	199	30	10	10	NUM
admet-1272	199	31	grams	gram	NOUN
admet-1272	199	32	of	of	ADP
admet-1272	199	33	a	a	DET
admet-1272	199	34	cgmp	cgmp	NOUN
admet-1272	199	35	product	product	NOUN
admet-1272	199	36	[	[	X
admet-1272	199	37	10	10	NUM
admet-1272	199	38	]	]	PUNCT
admet-1272	199	39	,	,	PUNCT
admet-1272	199	40	together	together	ADV
admet-1272	199	41	with	with	ADP
admet-1272	199	42	the	the	DET
admet-1272	199	43	production	production	NOUN
admet-1272	199	44	of	of	ADP
admet-1272	199	45	1	1	NUM
admet-1272	199	46	gram	gram	NOUN
admet-1272	199	47	of	of	ADP
admet-1272	199	48	cgmp	cgmp	PROPN
admet-1272	199	49	bryostatin	bryostatin	PROPN
admet-1272	199	50	1	1	NUM
admet-1272	199	51	by	by	ADP
admet-1272	199	52	the	the	DET
admet-1272	199	53	wender	wender	NOUN
admet-1272	199	54	group	group	NOUN
admet-1272	199	55	[	[	X
admet-1272	199	56	52	52	NUM
admet-1272	199	57	]	]	PUNCT
admet-1272	199	58	.	.	PUNCT
admet-1272	200	1	the	the	DET
admet-1272	200	2	compounds	compound	NOUN
admet-1272	200	3	referred	refer	VERB
admet-1272	200	4	to	to	ADP
admet-1272	200	5	in	in	ADP
admet-1272	200	6	the	the	DET
admet-1272	200	7	previous	previous	ADJ
admet-1272	200	8	paragraph	paragraph	NOUN
admet-1272	200	9	and	and	CCONJ
admet-1272	200	10	those	those	PRON
admet-1272	200	11	alluded	allude	VERB
admet-1272	200	12	to	to	ADP
admet-1272	200	13	in	in	ADP
admet-1272	200	14	the	the	DET
admet-1272	200	15	body	body	NOUN
admet-1272	200	16	of	of	ADP
admet-1272	200	17	the	the	DET
admet-1272	200	18	text	text	NOUN
admet-1272	200	19	are	be	AUX
admet-1272	200	20	just	just	ADV
admet-1272	200	21	some	some	DET
admet-1272	200	22	examples	example	NOUN
admet-1272	200	23	of	of	ADP
admet-1272	200	24	the	the	DET
admet-1272	200	25	many	many	ADJ
admet-1272	200	26	totally	totally	ADV
admet-1272	200	27	synthetic	synthetic	ADJ
admet-1272	200	28	methods	method	NOUN
admet-1272	200	29	described	describe	VERB
admet-1272	200	30	in	in	ADP
admet-1272	200	31	the	the	DET
admet-1272	200	32	literature	literature	NOUN
admet-1272	200	33	for	for	ADP
admet-1272	200	34	bioactive	bioactive	ADJ
admet-1272	200	35	agents	agent	NOUN
admet-1272	200	36	from	from	ADP
admet-1272	200	37	natural	natural	ADJ
admet-1272	200	38	product	product	NOUN
admet-1272	200	39	sources	source	NOUN
admet-1272	200	40	in	in	ADP
admet-1272	200	41	the	the	DET
admet-1272	200	42	relatively	relatively	ADV
admet-1272	200	43	recent	recent	ADJ
admet-1272	200	44	past	past	NOUN
admet-1272	200	45	,	,	PUNCT
admet-1272	200	46	covering	cover	VERB
admet-1272	200	47	compounds	compound	NOUN
admet-1272	200	48	in	in	ADP
admet-1272	200	49	many	many	ADJ
admet-1272	200	50	biological	biological	ADJ
admet-1272	200	51	areas	area	NOUN
admet-1272	200	52	.	.	PUNCT
admet-1272	201	1	it	it	PRON
admet-1272	201	2	should	should	AUX
admet-1272	201	3	also	also	ADV
admet-1272	201	4	be	be	AUX
admet-1272	201	5	noted	note	VERB
admet-1272	201	6	that	that	SCONJ
admet-1272	201	7	semi	semi	NOUN
admet-1272	201	8	-	-	NOUN
admet-1272	201	9	syntheses	synthesis	NOUN
admet-1272	201	10	starting	start	VERB
admet-1272	201	11	from	from	ADP
admet-1272	201	12	a	a	DET
admet-1272	201	13	natural	natural	ADJ
admet-1272	201	14	product	product	NOUN
admet-1272	201	15	precursor	precursor	NOUN
admet-1272	201	16	have	have	AUX
admet-1272	201	17	been	be	AUX
admet-1272	201	18	a	a	DET
admet-1272	201	19	routine	routine	ADJ
admet-1272	201	20	technique	technique	NOUN
admet-1272	201	21	practiced	practice	VERB
admet-1272	201	22	by	by	ADP
admet-1272	201	23	many	many	ADJ
admet-1272	201	24	chemists	chemist	NOUN
admet-1272	201	25	,	,	PUNCT
admet-1272	201	26	particularly	particularly	ADV
admet-1272	201	27	with	with	ADP
admet-1272	201	28	marine	marine	NOUN
admet-1272	201	29	-	-	PUNCT
admet-1272	201	30	sourced	source	VERB
admet-1272	201	31	bioactive	bioactive	ADJ
admet-1272	201	32	agents	agent	NOUN
admet-1272	201	33	and	and	CCONJ
admet-1272	201	34	have	have	AUX
admet-1272	201	35	been	be	AUX
admet-1272	201	36	covered	cover	VERB
admet-1272	201	37	in	in	ADP
admet-1272	201	38	detail	detail	NOUN
admet-1272	201	39	by	by	ADP
admet-1272	201	40	many	many	ADJ
admet-1272	201	41	authors	author	NOUN
admet-1272	201	42	.	.	PUNCT
admet-1272	202	1	as	as	ADP
admet-1272	202	2	a	a	DET
admet-1272	202	3	result	result	NOUN
admet-1272	202	4	,	,	PUNCT
admet-1272	202	5	for	for	ADP
admet-1272	202	6	“	"	PUNCT
admet-1272	202	7	antibiotic	antibiotic	ADJ
admet-1272	202	8	discoverers	discoverer	NOUN
admet-1272	202	9	/	/	SYM
admet-1272	202	10	developers	developer	NOUN
admet-1272	202	11	”	"	PUNCT
admet-1272	202	12	of	of	ADP
admet-1272	202	13	today	today	NOUN
admet-1272	202	14	,	,	PUNCT
admet-1272	202	15	a	a	DET
admet-1272	202	16	close	close	ADJ
admet-1272	202	17	relationship	relationship	NOUN
admet-1272	202	18	between	between	ADP
admet-1272	202	19	microbiologists	microbiologist	NOUN
admet-1272	202	20	,	,	PUNCT
admet-1272	202	21	natural	natural	ADJ
admet-1272	202	22	products	product	NOUN
admet-1272	202	23	and	and	CCONJ
admet-1272	202	24	synthetic	synthetic	ADJ
admet-1272	202	25	chemists	chemist	NOUN
admet-1272	202	26	may	may	AUX
admet-1272	202	27	well	well	ADV
admet-1272	202	28	be	be	AUX
admet-1272	202	29	the	the	DET
admet-1272	202	30	current	current	ADJ
admet-1272	202	31	optimal	optimal	ADJ
admet-1272	202	32	linkage	linkage	NOUN
admet-1272	202	33	to	to	PART
admet-1272	202	34	find	find	VERB
admet-1272	202	35	and	and	CCONJ
admet-1272	202	36	subsequently	subsequently	ADV
admet-1272	202	37	develop	develop	VERB
admet-1272	202	38	novel	novel	ADJ
admet-1272	202	39	agents	agent	NOUN
admet-1272	202	40	with	with	ADP
admet-1272	202	41	clinical	clinical	ADJ
admet-1272	202	42	relevance	relevance	NOUN
admet-1272	202	43	.	.	PUNCT
admet-1272	203	1	in	in	ADP
admet-1272	203	2	addition	addition	NOUN
admet-1272	203	3	,	,	PUNCT
admet-1272	203	4	the	the	DET
admet-1272	203	5	advent	advent	NOUN
admet-1272	203	6	of	of	ADP
admet-1272	203	7	searchable	searchable	ADJ
admet-1272	203	8	databases	database	NOUN
admet-1272	203	9	that	that	PRON
admet-1272	203	10	cover	cover	VERB
admet-1272	203	11	compounds	compound	NOUN
admet-1272	203	12	,	,	PUNCT
admet-1272	203	13	activities	activity	NOUN
admet-1272	203	14	and	and	CCONJ
admet-1272	203	15	genomic	genomic	ADJ
admet-1272	203	16	information	information	NOUN
admet-1272	203	17	should	should	AUX
admet-1272	203	18	also	also	ADV
admet-1272	203	19	be	be	AUX
admet-1272	203	20	part	part	NOUN
admet-1272	203	21	of	of	ADP
admet-1272	203	22	the	the	DET
admet-1272	203	23	mixture	mixture	NOUN
admet-1272	203	24	required	require	VERB
admet-1272	203	25	to	to	PART
admet-1272	203	26	discover	discover	VERB
admet-1272	203	27	and	and	CCONJ
admet-1272	203	28	develop	develop	VERB
admet-1272	203	29	agents	agent	NOUN
admet-1272	203	30	against	against	ADP
admet-1272	203	31	the	the	DET
admet-1272	203	32	ever	ever	ADV
admet-1272	203	33	-	-	PUNCT
admet-1272	203	34	increasing	increase	VERB
admet-1272	203	35	number	number	NOUN
admet-1272	203	36	of	of	ADP
admet-1272	203	37	resistant	resistant	ADJ
admet-1272	203	38	microbes	microbe	NOUN
admet-1272	203	39	.	.	PUNCT
admet-1272	204	1	admet	admet	PROPN
admet-1272	204	2	&	&	CCONJ
admet-1272	204	3	dmpk	dmpk	PROPN
admet-1272	204	4	10(2	10(2	NUM
admet-1272	204	5	)	)	PUNCT
admet-1272	204	6	(	(	PUNCT
admet-1272	204	7	2022	2022	NUM
admet-1272	204	8	)	)	PUNCT
admet-1272	204	9	131	131	NUM
admet-1272	204	10	-	-	SYM
admet-1272	204	11	146	146	NUM
admet-1272	204	12	chemical	chemical	NOUN
admet-1272	204	13	syntheses	synthesis	NOUN
admet-1272	204	14	and	and	CCONJ
admet-1272	204	15	resistant	resistant	ADJ
admet-1272	204	16	antibiotics	antibiotic	NOUN
admet-1272	204	17	doi	doi	NOUN
admet-1272	204	18	:	:	PUNCT
admet-1272	204	19	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	NUM
admet-1272	204	20	143	143	NUM
admet-1272	204	21	figure	figure	NOUN
admet-1272	204	22	6	6	NUM
admet-1272	204	23	.	.	PUNCT
admet-1272	204	24	malacidin	malacidin	VERB
admet-1272	204	25	a	a	PRON
admet-1272	204	26	and	and	CCONJ
admet-1272	204	27	b	b	NOUN
admet-1272	204	28	;	;	PUNCT
admet-1272	204	29	structures	structure	NOUN
admet-1272	204	30	25	25	NUM
admet-1272	204	31	to	to	PART
admet-1272	204	32	26	26	NUM
admet-1272	204	33	conflict	conflict	NOUN
admet-1272	204	34	of	of	ADP
admet-1272	204	35	interest	interest	NOUN
admet-1272	204	36	.	.	PUNCT
admet-1272	205	1	there	there	PRON
admet-1272	205	2	are	be	VERB
admet-1272	205	3	no	no	DET
admet-1272	205	4	coi	coi	NOUN
admet-1272	205	5	’s	’s	ADJ
admet-1272	205	6	to	to	PART
admet-1272	205	7	report	report	VERB
admet-1272	205	8	.	.	PUNCT
admet-1272	206	1	all	all	DET
admet-1272	206	2	work	work	NOUN
admet-1272	206	3	was	be	AUX
admet-1272	206	4	performed	perform	VERB
admet-1272	206	5	by	by	ADP
admet-1272	206	6	me	i	PRON
admet-1272	206	7	including	include	VERB
admet-1272	206	8	the	the	DET
admet-1272	206	9	structures	structure	NOUN
admet-1272	206	10	from	from	ADP
admet-1272	206	11	public	public	ADJ
admet-1272	206	12	sources	source	NOUN
admet-1272	206	13	.	.	PUNCT
admet-1272	207	1	references	reference	NOUN
admet-1272	207	2	[	[	X
admet-1272	207	3	1	1	NUM
admet-1272	207	4	]	]	X
admet-1272	207	5	d.j	d.j	PROPN
admet-1272	207	6	.	.	PROPN
admet-1272	207	7	payne	payne	PROPN
admet-1272	207	8	,	,	PUNCT
admet-1272	207	9	m.n	m.n	PROPN
admet-1272	207	10	.	.	PROPN
admet-1272	207	11	gwynn	gwynn	PROPN
admet-1272	207	12	,	,	PUNCT
admet-1272	207	13	d.j	d.j	PROPN
admet-1272	207	14	.	.	PROPN
admet-1272	207	15	holmes	holmes	PROPN
admet-1272	207	16	,	,	PUNCT
admet-1272	207	17	d.l	d.l	PROPN
admet-1272	207	18	.	.	PROPN
admet-1272	207	19	pompliano	pompliano	PROPN
admet-1272	207	20	.	.	PUNCT
admet-1272	208	1	drugs	drug	NOUN
admet-1272	208	2	for	for	ADP
admet-1272	208	3	bad	bad	ADJ
admet-1272	208	4	bugs	bug	NOUN
admet-1272	208	5	:	:	PUNCT
admet-1272	208	6	confronting	confront	VERB
admet-1272	208	7	the	the	DET
admet-1272	208	8	challenges	challenge	NOUN
admet-1272	208	9	of	of	ADP
admet-1272	208	10	antibacterial	antibacterial	ADJ
admet-1272	208	11	discovery	discovery	NOUN
admet-1272	208	12	.	.	PUNCT
admet-1272	209	1	nat	nat	PROPN
admet-1272	209	2	.	.	PUNCT
admet-1272	210	1	rev	rev	PROPN
admet-1272	210	2	.	.	PROPN
admet-1272	210	3	drug	drug	NOUN
admet-1272	210	4	discov	discov	NOUN
admet-1272	210	5	.	.	PUNCT
admet-1272	211	1	6	6	NUM
admet-1272	211	2	(	(	PUNCT
admet-1272	211	3	2007	2007	NUM
admet-1272	211	4	)	)	PUNCT
admet-1272	211	5	29	29	NUM
admet-1272	211	6	-	-	SYM
admet-1272	211	7	40	40	NUM
admet-1272	211	8	.	.	PUNCT
admet-1272	212	1	https://doi.org/10.1038/nrd2201	https://doi.org/10.1038/nrd2201	NOUN
admet-1272	212	2	.	.	PUNCT
admet-1272	213	1	[	[	X
admet-1272	213	2	2	2	NUM
admet-1272	213	3	]	]	X
admet-1272	213	4	m.a.t	m.a.t	NOUN
admet-1272	213	5	.	.	PROPN
admet-1272	213	6	blaskovich	blaskovich	PROPN
admet-1272	213	7	,	,	PUNCT
admet-1272	213	8	j.	j.	PROPN
admet-1272	213	9	zuegg	zuegg	PROPN
admet-1272	213	10	,	,	PUNCT
admet-1272	213	11	a.g	a.g	PROPN
admet-1272	213	12	.	.	PROPN
admet-1272	213	13	elliott	elliott	PROPN
admet-1272	213	14	,	,	PUNCT
admet-1272	213	15	m.a	m.a	PROPN
admet-1272	213	16	.	.	PROPN
admet-1272	213	17	cooper	cooper	PROPN
admet-1272	213	18	.	.	PUNCT
admet-1272	214	1	helping	help	VERB
admet-1272	214	2	chemists	chemist	NOUN
admet-1272	214	3	discover	discover	VERB
admet-1272	214	4	new	new	ADJ
admet-1272	214	5	antibiotics	antibiotic	NOUN
admet-1272	214	6	.	.	PUNCT
admet-1272	215	1	acs	acs	PROPN
admet-1272	215	2	infect	infect	VERB
admet-1272	215	3	.	.	PUNCT
admet-1272	216	1	dis	dis	PROPN
admet-1272	216	2	.	.	PROPN
admet-1272	217	1	1	1	NUM
admet-1272	217	2	(	(	PUNCT
admet-1272	217	3	2015	2015	NUM
admet-1272	217	4	)	)	PUNCT
admet-1272	217	5	285	285	NUM
admet-1272	217	6	-	-	SYM
admet-1272	217	7	287	287	NUM
admet-1272	217	8	.	.	PUNCT
admet-1272	218	1	https://doi.org/10.1021/acsinfecdis.5b00044	https://doi.org/10.1021/acsinfecdis.5b00044	X
admet-1272	218	2	.	.	PUNCT
admet-1272	219	1	[	[	X
admet-1272	219	2	3	3	NUM
admet-1272	219	3	]	]	X
admet-1272	219	4	m.s	m.s	PROPN
admet-1272	219	5	.	.	PROPN
admet-1272	219	6	butler	butler	PROPN
admet-1272	219	7	,	,	PUNCT
admet-1272	219	8	k.a	k.a	PROPN
admet-1272	219	9	.	.	PROPN
admet-1272	219	10	hansford	hansford	PROPN
admet-1272	219	11	,	,	PUNCT
admet-1272	219	12	m.a.t	m.a.t	NOUN
admet-1272	219	13	.	.	PROPN
admet-1272	219	14	blaskovich	blaskovich	PROPN
admet-1272	219	15	,	,	PUNCT
admet-1272	219	16	r.	r.	PROPN
admet-1272	219	17	halai	halai	PROPN
admet-1272	219	18	,	,	PUNCT
admet-1272	219	19	m.a	m.a	PROPN
admet-1272	219	20	.	.	PROPN
admet-1272	219	21	cooper	cooper	PROPN
admet-1272	219	22	.	.	PUNCT
admet-1272	219	23	glycopeptide	glycopeptide	PROPN
admet-1272	219	24	antibiotics	antibiotic	NOUN
admet-1272	219	25	:	:	PUNCT
admet-1272	219	26	back	back	ADV
admet-1272	219	27	to	to	ADP
admet-1272	219	28	the	the	DET
admet-1272	219	29	future	future	NOUN
admet-1272	219	30	.	.	PUNCT
admet-1272	220	1	j.	j.	PROPN
admet-1272	220	2	antibiot	antibiot	PROPN
admet-1272	220	3	.	.	PUNCT
admet-1272	221	1	67	67	NUM
admet-1272	221	2	(	(	PUNCT
admet-1272	221	3	2014	2014	NUM
admet-1272	221	4	)	)	PUNCT
admet-1272	221	5	631	631	NUM
admet-1272	221	6	-	-	SYM
admet-1272	221	7	644	644	NUM
admet-1272	221	8	.	.	PUNCT
admet-1272	222	1	https://doi.org/10.1038/ja.2014.111	https://doi.org/10.1038/ja.2014.111	NOUN
admet-1272	222	2	.	.	PUNCT
admet-1272	223	1	[	[	X
admet-1272	223	2	4	4	NUM
admet-1272	223	3	]	]	X
admet-1272	223	4	c.m	c.m	PROPN
admet-1272	223	5	.	.	PROPN
admet-1272	223	6	harris	harris	PROPN
admet-1272	223	7	,	,	PUNCT
admet-1272	223	8	t.m	t.m	PROPN
admet-1272	223	9	.	.	PROPN
admet-1272	223	10	harris	harris	PROPN
admet-1272	223	11	.	.	PUNCT
admet-1272	224	1	structure	structure	NOUN
admet-1272	224	2	of	of	ADP
admet-1272	224	3	the	the	DET
admet-1272	224	4	glycopeptide	glycopeptide	NOUN
admet-1272	224	5	antibiotic	antibiotic	ADJ
admet-1272	224	6	vancomycin	vancomycin	PROPN
admet-1272	224	7	.	.	PUNCT
admet-1272	225	1	evidence	evidence	NOUN
admet-1272	225	2	for	for	ADP
admet-1272	225	3	an	an	DET
admet-1272	225	4	asparagine	asparagine	NOUN
admet-1272	225	5	residue	residue	NOUN
admet-1272	225	6	in	in	ADP
admet-1272	225	7	the	the	DET
admet-1272	225	8	peptide	peptide	NOUN
admet-1272	225	9	.	.	PUNCT
admet-1272	226	1	j.	j.	PROPN
admet-1272	226	2	am	am	PROPN
admet-1272	226	3	.	.	PUNCT
admet-1272	227	1	chem	chem	NOUN
admet-1272	227	2	.	.	PUNCT
admet-1272	228	1	soc	soc	PROPN
admet-1272	228	2	.	.	PUNCT
admet-1272	229	1	104	104	NUM
admet-1272	229	2	(	(	PUNCT
admet-1272	229	3	1982	1982	NUM
admet-1272	229	4	)	)	PUNCT
admet-1272	229	5	4293	4293	NUM
admet-1272	229	6	-	-	SYM
admet-1272	229	7	4295	4295	NUM
admet-1272	229	8	.	.	PUNCT
admet-1272	230	1	https://doi.org/10.1021/ja00379a062	https://doi.org/10.1021/ja00379a062	X
admet-1272	230	2	.	.	PUNCT
admet-1272	231	1	[	[	X
admet-1272	231	2	5	5	NUM
admet-1272	231	3	]	]	X
admet-1272	231	4	v.m	v.m	PROPN
admet-1272	231	5	.	.	PROPN
admet-1272	231	6	d'costa	d'costa	PROPN
admet-1272	231	7	,	,	PUNCT
admet-1272	231	8	c.e	c.e	PROPN
admet-1272	231	9	.	.	PROPN
admet-1272	231	10	king	king	PROPN
admet-1272	231	11	,	,	PUNCT
admet-1272	231	12	l.	l.	PROPN
admet-1272	231	13	kalan	kalan	PROPN
admet-1272	231	14	,	,	PUNCT
admet-1272	231	15	m.	m.	PROPN
admet-1272	231	16	morar	morar	PROPN
admet-1272	231	17	,	,	PUNCT
admet-1272	231	18	w.w.l	w.w.l	PROPN
admet-1272	231	19	.	.	PUNCT
admet-1272	231	20	sung	sung	PROPN
admet-1272	231	21	,	,	PUNCT
admet-1272	231	22	c.	c.	PROPN
admet-1272	231	23	schwarz	schwarz	PROPN
admet-1272	231	24	,	,	PUNCT
admet-1272	231	25	d.	d.	PROPN
admet-1272	231	26	froese	froese	PROPN
admet-1272	231	27	,	,	PUNCT
admet-1272	231	28	g.	g.	PROPN
admet-1272	231	29	zazula	zazula	PROPN
admet-1272	231	30	,	,	PUNCT
admet-1272	231	31	f.	f.	PROPN
admet-1272	231	32	calmels	calmels	PROPN
admet-1272	231	33	,	,	PUNCT
admet-1272	231	34	r.	r.	PROPN
admet-1272	231	35	debruyne	debruyne	PROPN
admet-1272	231	36	,	,	PUNCT
admet-1272	231	37	g.b	g.b	PROPN
admet-1272	231	38	.	.	PROPN
admet-1272	231	39	goldiing	goldiing	PROPN
admet-1272	231	40	,	,	PUNCT
admet-1272	231	41	h.n	h.n	PROPN
admet-1272	231	42	.	.	PROPN
admet-1272	231	43	poinar	poinar	PROPN
admet-1272	231	44	,	,	PUNCT
admet-1272	231	45	g.d	g.d	PROPN
admet-1272	231	46	.	.	PROPN
admet-1272	231	47	wright	wright	PROPN
admet-1272	231	48	.	.	PUNCT
admet-1272	232	1	antibiotic	antibiotic	ADJ
admet-1272	232	2	resistance	resistance	NOUN
admet-1272	232	3	is	be	AUX
admet-1272	232	4	ancient	ancient	ADJ
admet-1272	232	5	.	.	PUNCT
admet-1272	233	1	nature	nature	NOUN
admet-1272	233	2	biotechnol	biotechnol	NOUN
admet-1272	233	3	.	.	PUNCT
admet-1272	234	1	477	477	NUM
admet-1272	234	2	(	(	PUNCT
admet-1272	234	3	2011	2011	NUM
admet-1272	234	4	)	)	PUNCT
admet-1272	234	5	457	457	NUM
admet-1272	234	6	-	-	SYM
admet-1272	234	7	461	461	NUM
admet-1272	234	8	.	.	PUNCT
admet-1272	235	1	https://doi.org/10.1038/nature10388	https://doi.org/10.1038/nature10388	NOUN
admet-1272	235	2	.	.	PUNCT
admet-1272	236	1	[	[	X
admet-1272	236	2	6	6	NUM
admet-1272	236	3	]	]	X
admet-1272	236	4	g.d	g.d	PROPN
admet-1272	236	5	.	.	PROPN
admet-1272	236	6	wright	wright	PROPN
admet-1272	236	7	,	,	PUNCT
admet-1272	236	8	h.	h.	PROPN
admet-1272	236	9	poinar	poinar	PROPN
admet-1272	236	10	.	.	PUNCT
admet-1272	237	1	antibiotic	antibiotic	ADJ
admet-1272	237	2	resistance	resistance	NOUN
admet-1272	237	3	is	be	AUX
admet-1272	237	4	ancient	ancient	ADJ
admet-1272	237	5	:	:	PUNCT
admet-1272	237	6	implications	implication	NOUN
admet-1272	237	7	for	for	ADP
admet-1272	237	8	drug	drug	NOUN
admet-1272	237	9	discovery	discovery	NOUN
admet-1272	237	10	.	.	PUNCT
admet-1272	238	1	trends	trend	NOUN
admet-1272	238	2	microbiol	microbiol	PROPN
admet-1272	238	3	.	.	PUNCT
admet-1272	239	1	20	20	NUM
admet-1272	239	2	(	(	PUNCT
admet-1272	239	3	2012	2012	NUM
admet-1272	239	4	)	)	PUNCT
admet-1272	239	5	157	157	NUM
admet-1272	239	6	-	-	SYM
admet-1272	239	7	159	159	NUM
admet-1272	239	8	.	.	PUNCT
admet-1272	240	1	https://doi.org/10.1016/j.tim.2012.01.002	https://doi.org/10.1016/j.tim.2012.01.002	NOUN
admet-1272	240	2	.	.	PUNCT
admet-1272	241	1	[	[	X
admet-1272	241	2	7	7	NUM
admet-1272	241	3	]	]	PUNCT
admet-1272	241	4	a.	a.	NOUN
admet-1272	241	5	okano	okano	PROPN
admet-1272	241	6	,	,	PUNCT
admet-1272	241	7	n.a	n.a	PROPN
admet-1272	241	8	.	.	PROPN
admet-1272	241	9	isley	isley	PROPN
admet-1272	241	10	,	,	PUNCT
admet-1272	241	11	d.l	d.l	PROPN
admet-1272	241	12	.	.	PROPN
admet-1272	241	13	boger	boger	PROPN
admet-1272	241	14	.	.	PUNCT
admet-1272	242	1	peripheral	peripheral	ADJ
admet-1272	242	2	modifications	modification	NOUN
admet-1272	242	3	of	of	ADP
admet-1272	242	4	[	[	X
admet-1272	242	5	ψ[ch2nh]tpg4]vancomycin	ψ[ch2nh]tpg4]vancomycin	NOUN
admet-1272	242	6	with	with	ADP
admet-1272	242	7	added	add	VERB
admet-1272	242	8	synergistic	synergistic	ADJ
admet-1272	242	9	mechanisms	mechanism	NOUN
admet-1272	242	10	of	of	ADP
admet-1272	242	11	action	action	NOUN
admet-1272	242	12	provide	provide	VERB
admet-1272	242	13	durable	durable	ADJ
admet-1272	242	14	and	and	CCONJ
admet-1272	242	15	potent	potent	ADJ
admet-1272	242	16	antibiotics	antibiotic	NOUN
admet-1272	242	17	.	.	PUNCT
admet-1272	243	1	proc	proc	NOUN
admet-1272	243	2	.	.	PUNCT
admet-1272	244	1	natl	natl	PROPN
admet-1272	244	2	.	.	PUNCT
admet-1272	245	1	acad	acad	PROPN
admet-1272	245	2	.	.	PUNCT
admet-1272	246	1	sci	sci	PROPN
admet-1272	246	2	.	.	PROPN
admet-1272	246	3	,	,	PUNCT
admet-1272	246	4	u.s.a	u.s.a	PROPN
admet-1272	246	5	.	.	PUNCT
admet-1272	246	6	(	(	PUNCT
admet-1272	246	7	2017	2017	NUM
admet-1272	246	8	)	)	PUNCT
admet-1272	246	9	e5052	e5052	PROPN
admet-1272	246	10	-	-	PROPN
admet-1272	246	11	e5061	e5061	PROPN
admet-1272	246	12	.	.	PUNCT
admet-1272	246	13	https://doi.org/10.1073/pnas.1704125114	https://doi.org/10.1073/pnas.1704125114	NOUN
admet-1272	246	14	.	.	PUNCT
admet-1272	247	1	[	[	X
admet-1272	247	2	8	8	NUM
admet-1272	247	3	]	]	PUNCT
admet-1272	247	4	z.-c	z.-c	PROPN
admet-1272	247	5	.	.	PUNCT
admet-1272	248	1	wu	wu	PROPN
admet-1272	248	2	,	,	PUNCT
admet-1272	248	3	m.d	m.d	PROPN
admet-1272	248	4	.	.	PROPN
admet-1272	248	5	cameron	cameron	PROPN
admet-1272	248	6	,	,	PUNCT
admet-1272	248	7	d.l	d.l	PROPN
admet-1272	248	8	.	.	PROPN
admet-1272	248	9	boger	boger	PROPN
admet-1272	248	10	.	.	PUNCT
admet-1272	249	1	vancomycin	vancomycin	PROPN
admet-1272	249	2	c‑terminus	c‑terminus	PROPN
admet-1272	249	3	guanidine	guanidine	NOUN
admet-1272	249	4	modifications	modification	NOUN
admet-1272	249	5	and	and	CCONJ
admet-1272	249	6	further	further	ADJ
admet-1272	249	7	insights	insight	NOUN
admet-1272	249	8	into	into	ADP
admet-1272	249	9	an	an	DET
admet-1272	249	10	added	add	VERB
admet-1272	249	11	mechanism	mechanism	NOUN
admet-1272	249	12	of	of	ADP
admet-1272	249	13	action	action	NOUN
admet-1272	249	14	imparted	impart	VERB
admet-1272	249	15	by	by	ADP
admet-1272	249	16	a	a	DET
admet-1272	249	17	peripheral	peripheral	ADJ
admet-1272	249	18	structural	structural	ADJ
admet-1272	249	19	modification	modification	NOUN
admet-1272	249	20	.	.	PUNCT
admet-1272	250	1	acs	acs	PROPN
admet-1272	250	2	infect	infect	VERB
admet-1272	250	3	.	.	PUNCT
admet-1272	251	1	dis	dis	PROPN
admet-1272	251	2	.	.	PROPN
admet-1272	252	1	6	6	NUM
admet-1272	252	2	(	(	PUNCT
admet-1272	252	3	2020	2020	NUM
admet-1272	252	4	)	)	PUNCT
admet-1272	252	5	2169	2169	NUM
admet-1272	252	6	-	-	SYM
admet-1272	252	7	2180	2180	NUM
admet-1272	252	8	.	.	PUNCT
admet-1272	253	1	https://doi.org/10.1021/acsinfecdis.0c00258	https://doi.org/10.1021/acsinfecdis.0c00258	NOUN
admet-1272	253	2	.	.	PUNCT
admet-1272	254	1	[	[	X
admet-1272	254	2	9	9	NUM
admet-1272	254	3	]	]	PUNCT
admet-1272	254	4	z.-c	z.-c	PROPN
admet-1272	254	5	.	.	PUNCT
admet-1272	254	6	wu	wu	PROPN
admet-1272	254	7	,	,	PUNCT
admet-1272	254	8	d.l	d.l	PROPN
admet-1272	254	9	.	.	PROPN
admet-1272	254	10	boger	boger	PROPN
admet-1272	254	11	.	.	PUNCT
admet-1272	255	1	maxamycins	maxamycin	NOUN
admet-1272	255	2	:	:	PUNCT
admet-1272	255	3	durable	durable	ADJ
admet-1272	255	4	antibiotics	antibiotic	NOUN
admet-1272	255	5	derived	derive	VERB
admet-1272	255	6	by	by	ADP
admet-1272	255	7	rational	rational	ADJ
admet-1272	255	8	redesign	redesign	NOUN
admet-1272	255	9	of	of	ADP
admet-1272	255	10	vancomycin	vancomycin	PROPN
admet-1272	255	11	.	.	PUNCT
admet-1272	255	12	acc	acc	PROPN
admet-1272	255	13	.	.	PROPN
admet-1272	255	14	chem	chem	PROPN
admet-1272	255	15	.	.	PUNCT
admet-1272	256	1	res	re	NOUN
admet-1272	256	2	.	.	PUNCT
admet-1272	257	1	53	53	NUM
admet-1272	257	2	(	(	PUNCT
admet-1272	257	3	2020	2020	NUM
admet-1272	257	4	)	)	PUNCT
admet-1272	257	5	2587	2587	NUM
admet-1272	257	6	-	-	SYM
admet-1272	257	7	2599	2599	NUM
admet-1272	257	8	.	.	PUNCT
admet-1272	258	1	https://doi.org/10.1021/acs.accounts.0c00569	https://doi.org/10.1021/acs.accounts.0c00569	NOUN
admet-1272	258	2	.	.	PUNCT
admet-1272	259	1	[	[	X
admet-1272	259	2	10	10	NUM
admet-1272	259	3	]	]	X
admet-1272	259	4	s.	s.	PROPN
admet-1272	259	5	kawano	kawano	PROPN
admet-1272	259	6	,	,	PUNCT
admet-1272	259	7	k.	k.	PROPN
admet-1272	259	8	ito	ito	PROPN
admet-1272	259	9	,	,	PUNCT
admet-1272	259	10	k.	k.	PROPN
admet-1272	259	11	yahata	yahata	PROPN
admet-1272	259	12	,	,	PUNCT
admet-1272	259	13	k.	k.	PROPN
admet-1272	259	14	kira	kira	PROPN
admet-1272	259	15	,	,	PUNCT
admet-1272	259	16	t.	t.	PROPN
admet-1272	259	17	abe	abe	PROPN
admet-1272	259	18	,	,	PUNCT
admet-1272	259	19	a.	a.	NOUN
admet-1272	259	20	t.	t.	PROPN
admet-1272	259	21	,	,	PUNCT
admet-1272	259	22	m.	m.	PROPN
admet-1272	259	23	asano	asano	PROPN
admet-1272	259	24	,	,	PUNCT
admet-1272	259	25	k.	k.	PROPN
admet-1272	259	26	iso	iso	PROPN
admet-1272	259	27	,	,	PUNCT
admet-1272	259	28	y.	y.	PROPN
admet-1272	259	29	sato	sato	PROPN
admet-1272	259	30	,	,	PUNCT
admet-1272	259	31	f.	f.	PROPN
admet-1272	259	32	matsuura	matsuura	PROPN
admet-1272	259	33	,	,	PUNCT
admet-1272	259	34	i.	i.	PROPN
admet-1272	259	35	ohashi	ohashi	PROPN
admet-1272	259	36	,	,	PUNCT
admet-1272	259	37	y.	y.	PROPN
admet-1272	259	38	matsumoto	matsumoto	PROPN
admet-1272	259	39	,	,	PUNCT
admet-1272	259	40	m.	m.	NOUN
admet-1272	259	41	isomura	isomura	PROPN
admet-1272	259	42	,	,	PUNCT
admet-1272	259	43	t.	t.	PROPN
admet-1272	259	44	sasaki	sasaki	PROPN
admet-1272	259	45	,	,	PUNCT
admet-1272	259	46	f.	f.	PROPN
admet-1272	259	47	t.	t.	PROPN
admet-1272	259	48	,	,	PUNCT
admet-1272	259	49	y.	y.	PROPN
admet-1272	259	50	miyashita	miyashita	PROPN
admet-1272	259	51	,	,	PUNCT
admet-1272	259	52	y.	y.	PROPN
admet-1272	259	53	kaburagi	kaburagi	PROPN
admet-1272	259	54	,	,	PUNCT
admet-1272	259	55	a.	a.	NOUN
admet-1272	259	56	yokoi	yokoi	PROPN
admet-1272	259	57	,	,	PUNCT
admet-1272	259	58	o.	o.	PROPN
admet-1272	259	59	asano	asano	PROPN
admet-1272	259	60	,	,	PUNCT
admet-1272	259	61	t.	t.	PROPN
admet-1272	259	62	owa	owa	PROPN
admet-1272	259	63	,	,	PUNCT
admet-1272	259	64	y.	y.	PROPN
admet-1272	259	65	kishi	kishi	PROPN
admet-1272	259	66	.	.	PUNCT
admet-1272	260	1	a	a	DET
admet-1272	260	2	landmark	landmark	NOUN
admet-1272	260	3	in	in	ADP
admet-1272	260	4	drug	drug	NOUN
admet-1272	260	5	discovery	discovery	NOUN
admet-1272	260	6	based	base	VERB
admet-1272	260	7	on	on	ADP
admet-1272	260	8	complex	complex	ADJ
admet-1272	260	9	natural	natural	ADJ
admet-1272	260	10	product	product	NOUN
admet-1272	260	11	synthesis	synthesis	NOUN
admet-1272	260	12	.	.	PUNCT
admet-1272	261	1	sci	sci	PROPN
admet-1272	261	2	.	.	PROPN
admet-1272	261	3	rep	rep	PROPN
admet-1272	261	4	.	.	PROPN
admet-1272	261	5	9	9	NUM
admet-1272	261	6	(	(	PUNCT
admet-1272	261	7	2019	2019	NUM
admet-1272	261	8	)	)	PUNCT
admet-1272	261	9	8656	8656	NUM
admet-1272	261	10	.	.	PUNCT
admet-1272	262	1	https://doi.org/10.1038/s41598-019-45001-9	https://doi.org/10.1038/s41598-019-45001-9	NUM
admet-1272	262	2	.	.	PUNCT
admet-1272	263	1	[	[	X
admet-1272	263	2	11	11	NUM
admet-1272	263	3	]	]	X
admet-1272	263	4	r.d	r.d	PROPN
admet-1272	263	5	.	.	PROPN
admet-1272	263	6	hutchison	hutchison	PROPN
admet-1272	263	7	,	,	PUNCT
admet-1272	263	8	p.s	p.s	PROPN
admet-1272	263	9	.	.	PROPN
admet-1272	263	10	steyn	steyn	PROPN
admet-1272	263	11	,	,	PUNCT
admet-1272	263	12	s.j	s.j	PROPN
admet-1272	263	13	.	.	PROPN
admet-1272	263	14	van	van	PROPN
admet-1272	263	15	rensburg	rensburg	PROPN
admet-1272	263	16	.	.	PUNCT
admet-1272	264	1	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	264	2	,	,	PUNCT
admet-1272	264	3	a	a	DET
admet-1272	264	4	new	new	ADJ
admet-1272	264	5	mycotoxin	mycotoxin	NOUN
admet-1272	264	6	from	from	ADP
admet-1272	264	7	penicillium	penicillium	NOUN
admet-1272	264	8	viridicatum	viridicatum	NOUN
admet-1272	264	9	westling	westling	NOUN
admet-1272	264	10	.	.	PUNCT
admet-1272	265	1	toxicol	toxicol	PROPN
admet-1272	265	2	.	.	PUNCT
admet-1272	265	3	appl	appl	PROPN
admet-1272	265	4	.	.	PUNCT
admet-1272	266	1	pharmacol	pharmacol	PROPN
admet-1272	266	2	.	.	PROPN
admet-1272	267	1	24	24	NUM
admet-1272	267	2	(	(	PUNCT
admet-1272	267	3	1973	1973	NUM
admet-1272	267	4	)	)	PUNCT
admet-1272	268	1	507−509	507−509	NOUN
admet-1272	268	2	.	.	PUNCT
admet-1272	269	1	https://doi.org/10.1016/0041008x(73)90057-4	https://doi.org/10.1016/0041008x(73)90057-4	NOUN
admet-1272	269	2	.	.	PROPN
admet-1272	269	3	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	PROPN
admet-1272	269	4	https://doi.org/10.1038/nrd2201	https://doi.org/10.1038/nrd2201	VERB
admet-1272	269	5	https://doi.org/10.1021/acsinfecdis.5b00044	https://doi.org/10.1021/acsinfecdis.5b00044	PROPN
admet-1272	269	6	https://doi.org/10.1038/ja.2014.111	https://doi.org/10.1038/ja.2014.111	NOUN
admet-1272	269	7	https://doi.org/10.1021/ja00379a062	https://doi.org/10.1021/ja00379a062	PROPN
admet-1272	269	8	https://doi.org/10.1021/ja00379a062	https://doi.org/10.1021/ja00379a062	PROPN
admet-1272	269	9	https://doi.org/10.1038/nature10388	https://doi.org/10.1038/nature10388	NOUN
admet-1272	269	10	https://doi.org/10.1016/j.tim.2012.01.002	https://doi.org/10.1016/j.tim.2012.01.002	NOUN
admet-1272	269	11	https://doi.org/10.1073/pnas.1704125114	https://doi.org/10.1073/pnas.1704125114	NOUN
admet-1272	269	12	https://doi.org/10.1021/acsinfecdis.0c00258	https://doi.org/10.1021/acsinfecdis.0c00258	PROPN
admet-1272	269	13	https://doi.org/10.1021/acs.accounts.0c00569	https://doi.org/10.1021/acs.accounts.0c00569	NOUN
admet-1272	269	14	https://doi.org/10.1038/s41598-019-45001-9	https://doi.org/10.1038/s41598-019-45001-9	NUM
admet-1272	270	1	https://doi.org/10.1016/0041-008x(73)90057-4	https://doi.org/10.1016/0041-008x(73)90057-4	PROPN
admet-1272	270	2	https://doi.org/10.1016/0041-008x(73)90057-4	https://doi.org/10.1016/0041-008x(73)90057-4	PROPN
admet-1272	270	3	david	david	PROPN
admet-1272	270	4	j.	j.	PROPN
admet-1272	270	5	newman	newman	PROPN
admet-1272	270	6	admet	admet	PROPN
admet-1272	270	7	&	&	CCONJ
admet-1272	270	8	dmpk	dmpk	PROPN
admet-1272	270	9	10(2	10(2	NUM
admet-1272	270	10	)	)	PUNCT
admet-1272	270	11	(	(	PUNCT
admet-1272	270	12	2022	2022	NUM
admet-1272	270	13	)	)	PUNCT
admet-1272	270	14	131	131	NUM
admet-1272	270	15	-	-	SYM
admet-1272	270	16	146	146	NUM
admet-1272	270	17	144	144	NUM
admet-1272	270	18	[	[	X
admet-1272	270	19	12	12	NUM
admet-1272	270	20	]	]	PUNCT
admet-1272	270	21	c.-j	c.-j	NOUN
admet-1272	270	22	.	.	PUNCT
admet-1272	271	1	zheng	zheng	PROPN
admet-1272	271	2	,	,	PUNCT
admet-1272	271	3	h.-e	h.-e	PROPN
admet-1272	271	4	.	.	PUNCT
admet-1272	272	1	yu	yu	PROPN
admet-1272	272	2	,	,	PUNCT
admet-1272	272	3	e.-h	e.-h	PROPN
admet-1272	272	4	.	.	PUNCT
admet-1272	273	1	kim	kim	PROPN
admet-1272	273	2	,	,	PUNCT
admet-1272	273	3	w.-g	w.-g	PROPN
admet-1272	273	4	.	.	PUNCT
admet-1272	274	1	kim	kim	PROPN
admet-1272	274	2	.	.	PUNCT
admet-1272	275	1	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	275	2	b	b	PROPN
admet-1272	275	3	,	,	PUNCT
admet-1272	275	4	a	a	DET
admet-1272	275	5	new	new	ADJ
admet-1272	275	6	anti	anti	ADJ
admet-1272	275	7	-	-	ADJ
admet-1272	275	8	mrsa	mrsa	ADJ
admet-1272	275	9	agent	agent	NOUN
admet-1272	275	10	from	from	ADP
admet-1272	275	11	penicillium	penicillium	NOUN
admet-1272	275	12	sp	sp	NOUN
admet-1272	275	13	.	.	PUNCT
admet-1272	276	1	fr11	fr11	PROPN
admet-1272	276	2	.	.	PUNCT
admet-1272	277	1	j.	j.	PROPN
admet-1272	277	2	antibiot	antibiot	PROPN
admet-1272	277	3	.	.	PUNCT
admet-1272	278	1	61	61	NUM
admet-1272	278	2	(	(	PUNCT
admet-1272	278	3	2008	2008	NUM
admet-1272	278	4	)	)	PUNCT
admet-1272	279	1	633−637	633−637	NUM
admet-1272	279	2	.	.	PUNCT
admet-1272	279	3	https://doi.org/10.1038/ja.2008.84	https://doi.org/10.1038/ja.2008.84	X
admet-1272	279	4	.	.	PUNCT
admet-1272	280	1	[	[	X
admet-1272	280	2	13	13	NUM
admet-1272	280	3	]	]	X
admet-1272	280	4	k.c	k.c	PROPN
admet-1272	280	5	.	.	PROPN
admet-1272	280	6	nicolaou	nicolaou	PROPN
admet-1272	280	7	,	,	PUNCT
admet-1272	280	8	c.	c.	PROPN
admet-1272	280	9	nilewski	nilewski	PROPN
admet-1272	280	10	,	,	PUNCT
admet-1272	280	11	c.r.h	c.r.h	NOUN
admet-1272	280	12	.	.	PROPN
admet-1272	280	13	hale	hale	PROPN
admet-1272	280	14	,	,	PUNCT
admet-1272	280	15	h.a	h.a	PROPN
admet-1272	280	16	.	.	PROPN
admet-1272	280	17	ioannidou	ioannidou	PROPN
admet-1272	280	18	,	,	PUNCT
admet-1272	280	19	a.	a.	PROPN
admet-1272	280	20	el	el	PROPN
admet-1272	280	21	marrouni	marrouni	PROPN
admet-1272	280	22	,	,	PUNCT
admet-1272	280	23	l.g	l.g	PROPN
admet-1272	280	24	.	.	PROPN
admet-1272	280	25	koch	koch	PROPN
admet-1272	280	26	.	.	PUNCT
admet-1272	281	1	total	total	ADJ
admet-1272	281	2	synthesis	synthesis	NOUN
admet-1272	281	3	and	and	CCONJ
admet-1272	281	4	structural	structural	ADJ
admet-1272	281	5	revision	revision	NOUN
admet-1272	281	6	of	of	ADP
admet-1272	281	7	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	281	8	b.	b.	PROPN
admet-1272	281	9	angew	angew	PROPN
admet-1272	281	10	.	.	PUNCT
admet-1272	282	1	chem	chem	PROPN
admet-1272	282	2	.	.	PUNCT
admet-1272	283	1	int	int	NOUN
admet-1272	283	2	.	.	PUNCT
admet-1272	284	1	ed	ed	NOUN
admet-1272	284	2	.	.	PROPN
admet-1272	285	1	52	52	NUM
admet-1272	285	2	(	(	PUNCT
admet-1272	285	3	2013	2013	NUM
admet-1272	285	4	)	)	PUNCT
admet-1272	285	5	8736	8736	NUM
admet-1272	285	6	-	-	SYM
admet-1272	285	7	8741	8741	NUM
admet-1272	285	8	.	.	PUNCT
admet-1272	286	1	https://doi.org/10.1002/anie.201304691	https://doi.org/10.1002/anie.201304691	X
admet-1272	286	2	.	.	PUNCT
admet-1272	287	1	[	[	X
admet-1272	287	2	14	14	NUM
admet-1272	287	3	]	]	X
admet-1272	287	4	k.c	k.c	PROPN
admet-1272	287	5	.	.	PROPN
admet-1272	287	6	nicolaou	nicolaou	PROPN
admet-1272	287	7	,	,	PUNCT
admet-1272	287	8	c.r.h	c.r.h	PROPN
admet-1272	287	9	.	.	PROPN
admet-1272	287	10	hale	hale	PROPN
admet-1272	287	11	,	,	PUNCT
admet-1272	287	12	c.	c.	PROPN
admet-1272	287	13	nilewski	nilewski	PROPN
admet-1272	287	14	,	,	PUNCT
admet-1272	287	15	h.a	h.a	PROPN
admet-1272	287	16	.	.	PROPN
admet-1272	287	17	ioannidou	ioannidou	PROPN
admet-1272	287	18	,	,	PUNCT
admet-1272	287	19	a.	a.	PROPN
admet-1272	287	20	el	el	PROPN
admet-1272	287	21	marrouni	marrouni	PROPN
admet-1272	287	22	,	,	PUNCT
admet-1272	287	23	l.g	l.g	PROPN
admet-1272	287	24	.	.	PROPN
admet-1272	287	25	nilewski	nilewski	PROPN
admet-1272	287	26	,	,	PUNCT
admet-1272	287	27	k.	k.	PROPN
admet-1272	287	28	beabout	beabout	PROPN
admet-1272	287	29	,	,	PUNCT
admet-1272	287	30	t.t	t.t	PROPN
admet-1272	287	31	.	.	PROPN
admet-1272	287	32	wang	wang	PROPN
admet-1272	287	33	,	,	PUNCT
admet-1272	287	34	y.	y.	PROPN
admet-1272	287	35	shamoo	shamoo	VERB
admet-1272	287	36	.	.	PUNCT
admet-1272	288	1	total	total	ADJ
admet-1272	288	2	synthesis	synthesis	NOUN
admet-1272	288	3	of	of	ADP
admet-1272	288	4	viridicatumtoxin	viridicatumtoxin	PROPN
admet-1272	288	5	b	b	PROPN
admet-1272	288	6	and	and	CCONJ
admet-1272	288	7	analogues	analogue	NOUN
admet-1272	288	8	thereof	thereof	ADV
admet-1272	288	9	:	:	PUNCT
admet-1272	288	10	strategy	strategy	NOUN
admet-1272	288	11	evolution	evolution	NOUN
admet-1272	288	12	,	,	PUNCT
admet-1272	288	13	structural	structural	ADJ
admet-1272	288	14	revision	revision	NOUN
admet-1272	288	15	,	,	PUNCT
admet-1272	288	16	and	and	CCONJ
admet-1272	288	17	biological	biological	ADJ
admet-1272	288	18	evaluation	evaluation	NOUN
admet-1272	288	19	.	.	PUNCT
admet-1272	289	1	j.	j.	PROPN
admet-1272	289	2	am	am	PROPN
admet-1272	289	3	.	.	PUNCT
admet-1272	290	1	chem	chem	NOUN
admet-1272	290	2	.	.	PUNCT
admet-1272	291	1	soc	soc	PROPN
admet-1272	291	2	.	.	PUNCT
admet-1272	292	1	136	136	NUM
admet-1272	292	2	(	(	PUNCT
admet-1272	292	3	2014	2014	NUM
admet-1272	292	4	)	)	PUNCT
admet-1272	292	5	12137	12137	NUM
admet-1272	292	6	-	-	SYM
admet-1272	292	7	12160	12160	NUM
admet-1272	292	8	.	.	PUNCT
admet-1272	293	1	https://doi.org/10.1021/ja506472u	https://doi.org/10.1021/ja506472u	ADV
admet-1272	293	2	.	.	PUNCT
admet-1272	294	1	[	[	X
admet-1272	294	2	15	15	NUM
admet-1272	294	3	]	]	X
admet-1272	294	4	m.t	m.t	PROPN
admet-1272	294	5	.	.	PROPN
admet-1272	294	6	drott	drott	PROPN
admet-1272	294	7	,	,	PUNCT
admet-1272	294	8	r.w	r.w	PROPN
admet-1272	294	9	.	.	PROPN
admet-1272	294	10	bastos	bastos	PROPN
admet-1272	294	11	,	,	PUNCT
admet-1272	294	12	a.	a.	NOUN
admet-1272	294	13	rokas	rokas	NOUN
admet-1272	294	14	,	,	PUNCT
admet-1272	294	15	l.n.a	l.n.a	NOUN
admet-1272	294	16	.	.	PUNCT
admet-1272	295	1	ries	rie	NOUN
admet-1272	295	2	,	,	PUNCT
admet-1272	295	3	t.	t.	NOUN
admet-1272	295	4	gabaldón	gabaldón	NOUN
admet-1272	295	5	,	,	PUNCT
admet-1272	295	6	g.h	g.h	PROPN
admet-1272	295	7	.	.	PROPN
admet-1272	295	8	goldman	goldman	PROPN
admet-1272	295	9	,	,	PUNCT
admet-1272	295	10	n.p	n.p	PROPN
admet-1272	295	11	.	.	PROPN
admet-1272	295	12	keller	keller	PROPN
admet-1272	295	13	,	,	PUNCT
admet-1272	295	14	c.	c.	PROPN
admet-1272	295	15	greco	greco	PROPN
admet-1272	295	16	.	.	PUNCT
admet-1272	296	1	diversity	diversity	NOUN
admet-1272	296	2	of	of	ADP
admet-1272	296	3	secondary	secondary	ADJ
admet-1272	296	4	metabolism	metabolism	NOUN
admet-1272	296	5	in	in	ADP
admet-1272	296	6	aspergillus	aspergillus	NOUN
admet-1272	296	7	nidulans	nidulans	ADP
admet-1272	296	8	clinical	clinical	ADJ
admet-1272	296	9	isolates	isolate	NOUN
admet-1272	296	10	.	.	PUNCT
admet-1272	297	1	msphere	msphere	PROPN
admet-1272	297	2	5	5	NUM
admet-1272	297	3	(	(	PUNCT
admet-1272	297	4	2020	2020	NUM
admet-1272	297	5	)	)	PUNCT
admet-1272	297	6	e0015600120	e0015600120	ADJ
admet-1272	297	7	.	.	PUNCT
admet-1272	297	8	https://doi.org/10.1128/msphere.00156-20	https://doi.org/10.1128/msphere.00156-20	NOUN
admet-1272	297	9	.	.	PUNCT
admet-1272	298	1	[	[	X
admet-1272	298	2	16	16	NUM
admet-1272	298	3	]	]	PUNCT
admet-1272	298	4	z.	z.	PROPN
admet-1272	298	5	shang	shang	PROPN
admet-1272	298	6	,	,	PUNCT
admet-1272	298	7	a.a	a.a	PROPN
admet-1272	298	8	.	.	PROPN
admet-1272	298	9	salim	salim	PROPN
admet-1272	298	10	,	,	PUNCT
admet-1272	298	11	z.	z.	PROPN
admet-1272	298	12	khalil	khalil	PROPN
admet-1272	298	13	,	,	PUNCT
admet-1272	298	14	p.v	p.v	PROPN
admet-1272	298	15	.	.	PROPN
admet-1272	298	16	bernhardt	bernhardt	PROPN
admet-1272	298	17	,	,	PUNCT
admet-1272	298	18	r.j	r.j	PROPN
admet-1272	298	19	.	.	NOUN
admet-1272	298	20	capon	capon	NOUN
admet-1272	298	21	.	.	PUNCT
admet-1272	299	1	fungal	fungal	ADJ
admet-1272	299	2	biotransformation	biotransformation	NOUN
admet-1272	299	3	of	of	ADP
admet-1272	299	4	tetracycline	tetracycline	PROPN
admet-1272	299	5	antibiotics	antibiotic	NOUN
admet-1272	299	6	.	.	PUNCT
admet-1272	300	1	j.	j.	PROPN
admet-1272	300	2	org	org	PROPN
admet-1272	300	3	.	.	PUNCT
admet-1272	300	4	chem	chem	PROPN
admet-1272	300	5	.	.	PUNCT
admet-1272	301	1	81	81	NUM
admet-1272	301	2	(	(	PUNCT
admet-1272	301	3	2016	2016	NUM
admet-1272	301	4	)	)	PUNCT
admet-1272	301	5	6186−6194	6186−6194	PROPN
admet-1272	301	6	.	.	PUNCT
admet-1272	301	7	https://doi.org/10.1021/acs.joc.6b01272	https://doi.org/10.1021/acs.joc.6b01272	NOUN
admet-1272	301	8	.	.	PUNCT
admet-1272	302	1	[	[	X
admet-1272	302	2	17	17	NUM
admet-1272	302	3	]	]	X
admet-1272	302	4	w.	w.	PROPN
admet-1272	302	5	li	li	PROPN
admet-1272	302	6	,	,	PUNCT
admet-1272	302	7	l.	l.	PROPN
admet-1272	302	8	l.	l.	PROPN
admet-1272	302	9	,	,	PUNCT
admet-1272	302	10	c.	c.	PROPN
admet-1272	302	11	zhang	zhang	PROPN
admet-1272	302	12	,	,	PUNCT
admet-1272	302	13	y.	y.	PROPN
admet-1272	302	14	cai	cai	PROPN
admet-1272	302	15	,	,	PUNCT
admet-1272	302	16	q.	q.	PROPN
admet-1272	302	17	gao	gao	PROPN
admet-1272	302	18	,	,	PUNCT
admet-1272	302	19	f.	f.	PROPN
admet-1272	302	20	wang	wang	PROPN
admet-1272	302	21	,	,	PUNCT
admet-1272	302	22	y.	y.	PROPN
admet-1272	302	23	cao	cao	PROPN
admet-1272	302	24	,	,	PUNCT
admet-1272	302	25	j.	j.	PROPN
admet-1272	302	26	jlin	jlin	PROPN
admet-1272	302	27	,	,	PUNCT
admet-1272	302	28	j.	j.	PROPN
admet-1272	302	29	li	li	PROPN
admet-1272	302	30	,	,	PUNCT
admet-1272	302	31	z.	z.	PROPN
admet-1272	302	32	shang	shang	PROPN
admet-1272	302	33	,	,	PUNCT
admet-1272	302	34	w.	w.	PROPN
admet-1272	302	35	lin	lin	PROPN
admet-1272	302	36	.	.	PUNCT
admet-1272	303	1	investigations	investigation	NOUN
admet-1272	303	2	into	into	ADP
admet-1272	303	3	the	the	DET
admet-1272	303	4	antibacterial	antibacterial	ADJ
admet-1272	303	5	mechanism	mechanism	NOUN
admet-1272	303	6	of	of	ADP
admet-1272	303	7	action	action	NOUN
admet-1272	303	8	of	of	ADP
admet-1272	303	9	viridicatumtoxins	viridicatumtoxin	NOUN
admet-1272	303	10	.	.	PUNCT
admet-1272	304	1	acs	acs	PROPN
admet-1272	304	2	infect	infect	VERB
admet-1272	304	3	.	.	PUNCT
admet-1272	305	1	dis	dis	PROPN
admet-1272	305	2	.	.	PROPN
admet-1272	306	1	6	6	NUM
admet-1272	306	2	(	(	PUNCT
admet-1272	306	3	2020	2020	NUM
admet-1272	306	4	)	)	PUNCT
admet-1272	306	5	1759−1769	1759−1769	NUM
admet-1272	306	6	.	.	PUNCT
admet-1272	307	1	https://doi.org/10.1021/acsinfecdis.0c00031	https://doi.org/10.1021/acsinfecdis.0c00031	NOUN
admet-1272	307	2	.	.	PUNCT
admet-1272	308	1	[	[	X
admet-1272	308	2	18	18	NUM
admet-1272	308	3	]	]	PUNCT
admet-1272	308	4	y.-y	y.-y	NOUN
admet-1272	308	5	.	.	PUNCT
admet-1272	309	1	liu	liu	PROPN
admet-1272	309	2	,	,	PUNCT
admet-1272	309	3	y.	y.	PROPN
admet-1272	309	4	wang	wang	PROPN
admet-1272	309	5	,	,	PUNCT
admet-1272	309	6	t.r	t.r	PROPN
admet-1272	309	7	.	.	PROPN
admet-1272	309	8	walsh	walsh	PROPN
admet-1272	309	9	,	,	PUNCT
admet-1272	309	10	l.-x	l.-x	PROPN
admet-1272	309	11	.	.	PUNCT
admet-1272	310	1	yi	yi	PROPN
admet-1272	310	2	,	,	PUNCT
admet-1272	310	3	r.	r.	PROPN
admet-1272	310	4	zhang	zhang	PROPN
admet-1272	310	5	,	,	PUNCT
admet-1272	310	6	j.	j.	PROPN
admet-1272	310	7	spencer	spencer	PROPN
admet-1272	310	8	,	,	PUNCT
admet-1272	310	9	y.	y.	PROPN
admet-1272	310	10	doi	doi	PROPN
admet-1272	310	11	,	,	PUNCT
admet-1272	310	12	g.	g.	PROPN
admet-1272	310	13	tian	tian	PROPN
admet-1272	310	14	,	,	PUNCT
admet-1272	310	15	b.	b.	PROPN
admet-1272	310	16	dong	dong	PROPN
admet-1272	310	17	,	,	PUNCT
admet-1272	310	18	x.	x.	PROPN
admet-1272	310	19	huang	huang	PROPN
admet-1272	310	20	,	,	PUNCT
admet-1272	310	21	l.-f	l.-f	NOUN
admet-1272	310	22	.	.	PUNCT
admet-1272	311	1	yu	yu	PROPN
admet-1272	311	2	,	,	PUNCT
admet-1272	311	3	d.	d.	PROPN
admet-1272	311	4	gu	gu	PROPN
admet-1272	311	5	,	,	PUNCT
admet-1272	311	6	h.	h.	PROPN
admet-1272	311	7	ren	ren	PROPN
admet-1272	311	8	,	,	PUNCT
admet-1272	311	9	x.	x.	PROPN
admet-1272	311	10	chen	chen	PROPN
admet-1272	311	11	,	,	PUNCT
admet-1272	311	12	l.	l.	PROPN
admet-1272	311	13	lv	lv	PROPN
admet-1272	311	14	,	,	PUNCT
admet-1272	311	15	d.	d.	PROPN
admet-1272	311	16	he	he	PRON
admet-1272	311	17	,	,	PUNCT
admet-1272	311	18	h.	h.	PROPN
admet-1272	311	19	zhou	zhou	PROPN
admet-1272	311	20	,	,	PUNCT
admet-1272	311	21	z.	z.	PROPN
admet-1272	311	22	liang	liang	PROPN
admet-1272	311	23	,	,	PUNCT
admet-1272	311	24	j.-h	j.-h	PROPN
admet-1272	311	25	.	.	PUNCT
admet-1272	312	1	liu	liu	PROPN
admet-1272	312	2	,	,	PUNCT
admet-1272	312	3	j.	j.	PROPN
admet-1272	312	4	shen	shen	PROPN
admet-1272	312	5	.	.	PUNCT
admet-1272	313	1	emergence	emergence	NOUN
admet-1272	313	2	of	of	ADP
admet-1272	313	3	plasmidmediated	plasmidmediate	VERB
admet-1272	313	4	colistin	colistin	NOUN
admet-1272	313	5	resistance	resistance	NOUN
admet-1272	313	6	mechanism	mechanism	NOUN
admet-1272	313	7	mcr-1	mcr-1	PUNCT
admet-1272	313	8	in	in	ADP
admet-1272	313	9	animals	animal	NOUN
admet-1272	313	10	and	and	CCONJ
admet-1272	313	11	human	human	ADJ
admet-1272	313	12	beings	being	NOUN
admet-1272	313	13	in	in	ADP
admet-1272	313	14	china	china	PROPN
admet-1272	313	15	:	:	PUNCT
admet-1272	313	16	a	a	DET
admet-1272	313	17	microbiological	microbiological	ADJ
admet-1272	313	18	and	and	CCONJ
admet-1272	313	19	molecular	molecular	ADJ
admet-1272	313	20	biological	biological	ADJ
admet-1272	313	21	study	study	NOUN
admet-1272	313	22	.	.	PUNCT
admet-1272	314	1	lancet	lancet	PROPN
admet-1272	314	2	infect	infect	PROPN
admet-1272	314	3	.	.	PUNCT
admet-1272	315	1	dis	dis	PROPN
admet-1272	315	2	.	.	PUNCT
admet-1272	316	1	16	16	NUM
admet-1272	316	2	(	(	PUNCT
admet-1272	316	3	2016	2016	NUM
admet-1272	316	4	)	)	PUNCT
admet-1272	316	5	161	161	NUM
admet-1272	316	6	-	-	SYM
admet-1272	316	7	168	168	NUM
admet-1272	316	8	.	.	PUNCT
admet-1272	317	1	https://doi.org/10.1016/s1473-3099(15)00424-7	https://doi.org/10.1016/s1473-3099(15)00424-7	NOUN
admet-1272	317	2	.	.	PUNCT
admet-1272	318	1	[	[	X
admet-1272	318	2	19	19	NUM
admet-1272	318	3	]	]	PUNCT
admet-1272	318	4	z.	z.	PROPN
admet-1272	318	5	cherak	cherak	PROPN
admet-1272	318	6	,	,	PUNCT
admet-1272	318	7	l.	l.	PROPN
admet-1272	318	8	loucif	loucif	PROPN
admet-1272	318	9	,	,	PUNCT
admet-1272	318	10	a.	a.	PROPN
admet-1272	318	11	moussi	moussi	PROPN
admet-1272	318	12	,	,	PUNCT
admet-1272	318	13	j.-m	j.-m	PROPN
admet-1272	318	14	.	.	PUNCT
admet-1272	319	1	rolain	rolain	PROPN
admet-1272	319	2	.	.	PUNCT
admet-1272	320	1	epidemiology	epidemiology	NOUN
admet-1272	320	2	of	of	ADP
admet-1272	320	3	mobile	mobile	PROPN
admet-1272	320	4	colistin	colistin	PROPN
admet-1272	320	5	resistance	resistance	NOUN
admet-1272	320	6	(	(	PUNCT
admet-1272	320	7	mcr	mcr	PROPN
admet-1272	320	8	)	)	PUNCT
admet-1272	320	9	genes	gene	NOUN
admet-1272	320	10	in	in	ADP
admet-1272	320	11	aquatic	aquatic	ADJ
admet-1272	320	12	environments	environment	NOUN
admet-1272	320	13	.	.	PUNCT
admet-1272	321	1	j.	j.	PROPN
admet-1272	321	2	global	global	PROPN
admet-1272	321	3	antimicro	antimicro	PROPN
admet-1272	321	4	.	.	PUNCT
admet-1272	322	1	resist	resist	VERB
admet-1272	322	2	.	.	PUNCT
admet-1272	323	1	27	27	NUM
admet-1272	323	2	(	(	PUNCT
admet-1272	323	3	2021	2021	NUM
admet-1272	323	4	)	)	PUNCT
admet-1272	323	5	51	51	NUM
admet-1272	323	6	-	-	SYM
admet-1272	323	7	62	62	NUM
admet-1272	323	8	.	.	PUNCT
admet-1272	324	1	https://doi.org/10.1016/j.jgar.2021.07.021	https://doi.org/10.1016/j.jgar.2021.07.021	NOUN
admet-1272	324	2	.	.	PUNCT
admet-1272	325	1	[	[	X
admet-1272	325	2	20	20	NUM
admet-1272	325	3	]	]	PUNCT
admet-1272	325	4	x.	x.	PROPN
admet-1272	325	5	jiang	jiang	PROPN
admet-1272	325	6	,	,	PUNCT
admet-1272	325	7	n.a	n.a	PROPN
admet-1272	325	8	.	.	PROPN
admet-1272	325	9	patil	patil	PROPN
admet-1272	325	10	,	,	PUNCT
admet-1272	325	11	m.a.k	m.a.k	PROPN
admet-1272	325	12	.	.	PUNCT
admet-1272	325	13	azad	azad	PROPN
admet-1272	325	14	,	,	PUNCT
admet-1272	325	15	wickremasinghe	wickremasinghe	PROPN
admet-1272	325	16	,	,	PUNCT
admet-1272	325	17	h.	h.	PROPN
admet-1272	325	18	,	,	PUNCT
admet-1272	325	19	h.	h.	PROPN
admet-1272	325	20	yu	yu	PROPN
admet-1272	325	21	,	,	PUNCT
admet-1272	325	22	j.	j.	PROPN
admet-1272	325	23	zhao	zhao	PROPN
admet-1272	325	24	,	,	PUNCT
admet-1272	325	25	x.	x.	PROPN
admet-1272	325	26	zhang	zhang	PROPN
admet-1272	325	27	,	,	PUNCT
admet-1272	325	28	m.	m.	PROPN
admet-1272	325	29	li	li	PROPN
admet-1272	325	30	,	,	PUNCT
admet-1272	325	31	b.	b.	PROPN
admet-1272	325	32	gong	gong	PROPN
admet-1272	325	33	,	,	PUNCT
admet-1272	325	34	l.	l.	PROPN
admet-1272	325	35	wan	wan	PROPN
admet-1272	325	36	,	,	PUNCT
admet-1272	325	37	w.	w.	PROPN
admet-1272	325	38	ma	ma	PROPN
admet-1272	325	39	,	,	PUNCT
admet-1272	325	40	p.e	p.e	PROPN
admet-1272	325	41	.	.	PROPN
admet-1272	325	42	thompson	thompson	PROPN
admet-1272	325	43	,	,	PUNCT
admet-1272	325	44	k.	k.	PROPN
admet-1272	325	45	yang	yang	PROPN
admet-1272	325	46	,	,	PUNCT
admet-1272	325	47	b.	b.	PROPN
admet-1272	325	48	yuan	yuan	PROPN
admet-1272	325	49	,	,	PUNCT
admet-1272	325	50	f.	f.	PROPN
admet-1272	325	51	schreiber	schreiber	PROPN
admet-1272	325	52	,	,	PUNCT
admet-1272	325	53	l.	l.	PROPN
admet-1272	325	54	wang	wang	PROPN
admet-1272	325	55	,	,	PUNCT
admet-1272	325	56	t.	t.	PROPN
admet-1272	325	57	velkov	velkov	PROPN
admet-1272	325	58	,	,	PUNCT
admet-1272	325	59	k.d	k.d	PROPN
admet-1272	325	60	.	.	PROPN
admet-1272	325	61	roberts	roberts	PROPN
admet-1272	325	62	,	,	PUNCT
admet-1272	325	63	j.	j.	PROPN
admet-1272	325	64	li	li	PROPN
admet-1272	325	65	.	.	PUNCT
admet-1272	326	1	a	a	DET
admet-1272	326	2	novel	novel	ADJ
admet-1272	326	3	chemical	chemical	NOUN
admet-1272	326	4	biology	biology	NOUN
admet-1272	326	5	and	and	CCONJ
admet-1272	326	6	computational	computational	ADJ
admet-1272	326	7	approach	approach	NOUN
admet-1272	326	8	to	to	PART
admet-1272	326	9	expedite	expedite	VERB
admet-1272	326	10	the	the	DET
admet-1272	326	11	discovery	discovery	NOUN
admet-1272	326	12	of	of	ADP
admet-1272	326	13	new	new	ADJ
admet-1272	326	14	generation	generation	NOUN
admet-1272	326	15	polymyxins	polymyxin	NOUN
admet-1272	326	16	against	against	ADP
admet-1272	326	17	life	life	NOUN
admet-1272	326	18	-	-	PUNCT
admet-1272	326	19	threatening	threaten	VERB
admet-1272	326	20	acinetobacter	acinetobacter	ADJ
admet-1272	326	21	baumannii	baumannii	PROPN
admet-1272	326	22	.	.	PUNCT
admet-1272	327	1	chem	chem	PROPN
admet-1272	327	2	.	.	PUNCT
admet-1272	328	1	sci	sci	PROPN
admet-1272	328	2	.	.	PROPN
admet-1272	329	1	12	12	NUM
admet-1272	329	2	(	(	PUNCT
admet-1272	329	3	2021	2021	NUM
admet-1272	329	4	)	)	PUNCT
admet-1272	329	5	12211	12211	NUM
admet-1272	329	6	.	.	PUNCT
admet-1272	330	1	https://doi.org/10.1039/d1sc03460j	https://doi.org/10.1039/d1sc03460j	X
admet-1272	330	2	.	.	PUNCT
admet-1272	331	1	[	[	X
admet-1272	331	2	21	21	NUM
admet-1272	331	3	]	]	X
admet-1272	331	4	m.	m.	NOUN
admet-1272	331	5	vaara	vaara	PROPN
admet-1272	331	6	.	.	PUNCT
admet-1272	332	1	polymyxins	polymyxin	NOUN
admet-1272	332	2	and	and	CCONJ
admet-1272	332	3	their	their	PRON
admet-1272	332	4	potential	potential	ADJ
admet-1272	332	5	next	next	ADJ
admet-1272	332	6	generation	generation	NOUN
admet-1272	332	7	as	as	ADP
admet-1272	332	8	therapeutic	therapeutic	ADJ
admet-1272	332	9	antibiotics	antibiotic	NOUN
admet-1272	332	10	.	.	PUNCT
admet-1272	333	1	front	front	ADJ
admet-1272	333	2	.	.	PUNCT
admet-1272	334	1	microbiol	microbiol	PROPN
admet-1272	334	2	.	.	PUNCT
admet-1272	335	1	10	10	NUM
admet-1272	335	2	(	(	PUNCT
admet-1272	335	3	2019	2019	NUM
admet-1272	335	4	)	)	PUNCT
admet-1272	335	5	1689	1689	NUM
admet-1272	335	6	.	.	PUNCT
admet-1272	336	1	https://doi.org/10.3389/fmicb.2019.01689	https://doi.org/10.3389/fmicb.2019.01689	NOUN
admet-1272	336	2	.	.	PUNCT
admet-1272	337	1	[	[	X
admet-1272	337	2	22	22	NUM
admet-1272	337	3	]	]	PUNCT
admet-1272	337	4	z.	z.	PROPN
admet-1272	337	5	wang	wang	PROPN
admet-1272	337	6	,	,	PUNCT
admet-1272	337	7	b.	b.	PROPN
admet-1272	337	8	koirala	koirala	PROPN
admet-1272	337	9	,	,	PUNCT
admet-1272	337	10	y.	y.	PROPN
admet-1272	337	11	hernandez	hernandez	PROPN
admet-1272	337	12	,	,	PUNCT
admet-1272	337	13	m.	m.	PROPN
admet-1272	337	14	zimmerman	zimmerman	PROPN
admet-1272	337	15	,	,	PUNCT
admet-1272	337	16	s.	s.	PROPN
admet-1272	337	17	park	park	PROPN
admet-1272	337	18	,	,	PUNCT
admet-1272	337	19	d.s	d.s	PROPN
admet-1272	337	20	.	.	PROPN
admet-1272	337	21	perlin	perlin	PROPN
admet-1272	337	22	,	,	PUNCT
admet-1272	337	23	s.f	s.f	PROPN
admet-1272	337	24	.	.	PROPN
admet-1272	337	25	brady	brady	PROPN
admet-1272	337	26	.	.	PUNCT
admet-1272	338	1	a	a	DET
admet-1272	338	2	naturally	naturally	ADV
admet-1272	338	3	inspired	inspire	VERB
admet-1272	338	4	antibiotic	antibiotic	ADJ
admet-1272	338	5	to	to	PART
admet-1272	338	6	target	target	VERB
admet-1272	338	7	multidrug	multidrug	NOUN
admet-1272	338	8	-	-	PUNCT
admet-1272	338	9	resistant	resistant	ADJ
admet-1272	338	10	pathogens	pathogen	NOUN
admet-1272	338	11	.	.	PUNCT
admet-1272	339	1	nature	nature	NOUN
admet-1272	339	2	601	601	NUM
admet-1272	339	3	(	(	PUNCT
admet-1272	339	4	2022	2022	NUM
admet-1272	339	5	)	)	PUNCT
admet-1272	339	6	606	606	NUM
admet-1272	339	7	-	-	SYM
admet-1272	339	8	611	611	NUM
admet-1272	339	9	.	.	PUNCT
admet-1272	340	1	https://doi.org/10.1038/s41586-021-04264-x	https://doi.org/10.1038/s41586-021-04264-x	PROPN
admet-1272	340	2	.	.	PUNCT
admet-1272	341	1	[	[	X
admet-1272	341	2	23	23	NUM
admet-1272	341	3	]	]	X
admet-1272	341	4	d.m	d.m	PROPN
admet-1272	341	5	.	.	PROPN
admet-1272	341	6	shlaes	shlaes	PROPN
admet-1272	341	7	,	,	PUNCT
admet-1272	341	8	j.h	j.h	PROPN
admet-1272	341	9	.	.	PROPN
admet-1272	341	10	shlaes	shlaes	PROPN
admet-1272	341	11	,	,	PUNCT
admet-1272	341	12	j.	j.	PROPN
admet-1272	341	13	davies	davies	PROPN
admet-1272	341	14	,	,	PUNCT
admet-1272	341	15	r.	r.	PROPN
admet-1272	341	16	williamson	williamson	PROPN
admet-1272	341	17	.	.	PUNCT
admet-1272	341	18	escherichia	escherichia	NOUN
admet-1272	341	19	coli	coli	NOUN
admet-1272	341	20	susceptible	susceptible	ADJ
admet-1272	341	21	to	to	PART
admet-1272	341	22	glycopeptide	glycopeptide	VERB
admet-1272	341	23	antibiotics	antibiotic	NOUN
admet-1272	341	24	.	.	PUNCT
admet-1272	342	1	antimicro	antimicro	PROPN
admet-1272	342	2	.	.	PUNCT
admet-1272	343	1	ag	ag	PROPN
admet-1272	343	2	.	.	PROPN
admet-1272	343	3	chemother	chemother	PROPN
admet-1272	343	4	.	.	PUNCT
admet-1272	344	1	33	33	NUM
admet-1272	344	2	(	(	PUNCT
admet-1272	344	3	1989	1989	NUM
admet-1272	344	4	)	)	PUNCT
admet-1272	344	5	192	192	NUM
admet-1272	344	6	-	-	SYM
admet-1272	344	7	197	197	NUM
admet-1272	344	8	.	.	PUNCT
admet-1272	345	1	https://doi.org/10.1128/aac.33.2.192	https://doi.org/10.1128/aac.33.2.192	NOUN
admet-1272	345	2	.	.	PUNCT
admet-1272	346	1	[	[	X
admet-1272	346	2	24	24	NUM
admet-1272	346	3	]	]	X
admet-1272	346	4	n.c	n.c	PROPN
admet-1272	346	5	.	.	PROPN
admet-1272	346	6	gordon	gordon	PROPN
admet-1272	346	7	,	,	PUNCT
admet-1272	346	8	k.	k.	PROPN
admet-1272	346	9	png	png	PROPN
admet-1272	346	10	,	,	PUNCT
admet-1272	346	11	d.w	d.w	PROPN
admet-1272	346	12	.	.	PROPN
admet-1272	346	13	wareham	wareham	PROPN
admet-1272	346	14	.	.	PUNCT
admet-1272	347	1	potent	potent	ADJ
admet-1272	347	2	synergy	synergy	NOUN
admet-1272	347	3	and	and	CCONJ
admet-1272	347	4	sustained	sustained	ADJ
admet-1272	347	5	bactericidal	bactericidal	ADJ
admet-1272	347	6	activity	activity	NOUN
admet-1272	347	7	of	of	ADP
admet-1272	347	8	a	a	DET
admet-1272	347	9	vancomycin	vancomycin	NOUN
admet-1272	347	10	-	-	PUNCT
admet-1272	347	11	colistin	colistin	NOUN
admet-1272	347	12	combination	combination	NOUN
admet-1272	347	13	versus	versus	ADP
admet-1272	347	14	multidrug	multidrug	NOUN
admet-1272	347	15	-	-	PUNCT
admet-1272	347	16	resistant	resistant	ADJ
admet-1272	347	17	strains	strain	NOUN
admet-1272	347	18	of	of	ADP
admet-1272	347	19	acinetobacter	acinetobacter	ADJ
admet-1272	347	20	baumannii	baumannii	PROPN
admet-1272	347	21	.	.	PUNCT
admet-1272	348	1	antimicro	antimicro	PROPN
admet-1272	348	2	.	.	PUNCT
admet-1272	349	1	ag	ag	PROPN
admet-1272	349	2	.	.	PROPN
admet-1272	349	3	chemother	chemother	PROPN
admet-1272	349	4	.	.	PUNCT
admet-1272	350	1	54	54	NUM
admet-1272	350	2	(	(	PUNCT
admet-1272	350	3	2010	2010	NUM
admet-1272	350	4	)	)	PUNCT
admet-1272	350	5	5316	5316	NUM
admet-1272	350	6	-	-	SYM
admet-1272	350	7	5322	5322	NUM
admet-1272	350	8	.	.	PUNCT
admet-1272	351	1	https://doi.org/10.1128/aac.00922-10	https://doi.org/10.1128/aac.00922-10	X
admet-1272	351	2	.	.	PUNCT
admet-1272	352	1	[	[	X
admet-1272	352	2	25	25	NUM
admet-1272	352	3	]	]	X
admet-1272	352	4	e.	e.	PROPN
admet-1272	352	5	van	van	PROPN
admet-1272	352	6	groesen	groesen	PROPN
admet-1272	352	7	,	,	PUNCT
admet-1272	352	8	c.j	c.j	PROPN
admet-1272	352	9	.	.	PROPN
admet-1272	352	10	slingerland	slingerland	PROPN
admet-1272	352	11	,	,	PUNCT
admet-1272	352	12	p.	p.	NOUN
admet-1272	352	13	innocenti	innocenti	PROPN
admet-1272	352	14	,	,	PUNCT
admet-1272	352	15	m.	m.	NOUN
admet-1272	352	16	mihajlovic	mihajlovic	PROPN
admet-1272	352	17	,	,	PUNCT
admet-1272	352	18	r.	r.	PROPN
admet-1272	352	19	masereeuw	masereeuw	PROPN
admet-1272	352	20	,	,	PUNCT
admet-1272	352	21	n.i	n.i	PROPN
admet-1272	352	22	.	.	PROPN
admet-1272	352	23	martin	martin	PROPN
admet-1272	352	24	.	.	PUNCT
admet-1272	353	1	vancomyxins	vancomyxin	NOUN
admet-1272	353	2	:	:	PUNCT
admet-1272	353	3	vancomycin	vancomycin	PROPN
admet-1272	353	4	-	-	PUNCT
admet-1272	353	5	polymyxin	polymyxin	ADJ
admet-1272	353	6	nonapeptide	nonapeptide	ADJ
admet-1272	353	7	conjugates	conjugate	NOUN
admet-1272	353	8	that	that	PRON
admet-1272	353	9	retain	retain	VERB
admet-1272	353	10	anti	anti	ADJ
admet-1272	353	11	-	-	ADJ
admet-1272	353	12	gram	gram	ADJ
admet-1272	353	13	-	-	PUNCT
admet-1272	353	14	positive	positive	ADJ
admet-1272	353	15	activity	activity	NOUN
admet-1272	353	16	with	with	ADP
admet-1272	353	17	enhanced	enhanced	ADJ
admet-1272	353	18	potency	potency	NOUN
admet-1272	353	19	against	against	ADP
admet-1272	353	20	gram	gram	NOUN
admet-1272	353	21	-	-	PUNCT
admet-1272	353	22	negative	negative	ADJ
admet-1272	353	23	strains	strain	NOUN
admet-1272	353	24	.	.	PUNCT
admet-1272	354	1	acs	acs	PROPN
admet-1272	354	2	infect	infect	VERB
admet-1272	354	3	.	.	PUNCT
admet-1272	355	1	dis	dis	INTJ
admet-1272	355	2	.	.	PROPN
admet-1272	356	1	7	7	NUM
admet-1272	356	2	(	(	PUNCT
admet-1272	356	3	2021	2021	NUM
admet-1272	356	4	)	)	PUNCT
admet-1272	356	5	2746	2746	NUM
admet-1272	356	6	-	-	SYM
admet-1272	356	7	2754	2754	NUM
admet-1272	356	8	.	.	PUNCT
admet-1272	357	1	https://doi.org/10.1021/acsinfecdis.1c00318	https://doi.org/10.1021/acsinfecdis.1c00318	NOUN
admet-1272	357	2	.	.	PUNCT
admet-1272	358	1	[	[	X
admet-1272	358	2	26	26	NUM
admet-1272	358	3	]	]	X
admet-1272	358	4	r.d	r.d	PROPN
admet-1272	358	5	.	.	PROPN
admet-1272	358	6	hotchkiss	hotchkiss	PROPN
admet-1272	358	7	,	,	PUNCT
admet-1272	358	8	r.j	r.j	PROPN
admet-1272	358	9	.	.	PROPN
admet-1272	358	10	dubos	dubos	PROPN
admet-1272	358	11	.	.	PUNCT
admet-1272	358	12	fractionation	fractionation	NOUN
admet-1272	358	13	of	of	ADP
admet-1272	358	14	the	the	DET
admet-1272	358	15	bacteriocidal	bacteriocidal	ADJ
admet-1272	358	16	agent	agent	NOUN
admet-1272	358	17	from	from	ADP
admet-1272	358	18	cultures	culture	NOUN
admet-1272	358	19	of	of	ADP
admet-1272	358	20	a	a	DET
admet-1272	358	21	soil	soil	NOUN
admet-1272	358	22	bacillus	bacillus	NOUN
admet-1272	358	23	.	.	PUNCT
admet-1272	359	1	j.	j.	PROPN
admet-1272	359	2	biol	biol	PROPN
admet-1272	359	3	.	.	PUNCT
admet-1272	360	1	chem	chem	PROPN
admet-1272	360	2	.	.	PUNCT
admet-1272	361	1	132	132	NUM
admet-1272	361	2	(	(	PUNCT
admet-1272	361	3	1940	1940	NUM
admet-1272	361	4	)	)	PUNCT
admet-1272	361	5	791	791	NUM
admet-1272	361	6	-	-	SYM
admet-1272	361	7	792	792	NUM
admet-1272	361	8	.	.	PUNCT
admet-1272	362	1	[	[	X
admet-1272	362	2	27	27	NUM
admet-1272	362	3	]	]	X
admet-1272	362	4	a.r	a.r	PROPN
admet-1272	362	5	.	.	PROPN
admet-1272	362	6	battersby	battersby	PROPN
admet-1272	362	7	,	,	PUNCT
admet-1272	362	8	l.c	l.c	PROPN
admet-1272	362	9	.	.	PROPN
admet-1272	362	10	craig	craig	PROPN
admet-1272	362	11	.	.	PUNCT
admet-1272	363	1	the	the	DET
admet-1272	363	2	chemistry	chemistry	NOUN
admet-1272	363	3	of	of	ADP
admet-1272	363	4	tyrocidine	tyrocidine	PROPN
admet-1272	363	5	.	.	PUNCT
admet-1272	364	1	i.	i.	PROPN
admet-1272	364	2	isolation	isolation	NOUN
admet-1272	364	3	and	and	CCONJ
admet-1272	364	4	characterization	characterization	NOUN
admet-1272	364	5	of	of	ADP
admet-1272	364	6	a	a	DET
admet-1272	364	7	single	single	ADJ
admet-1272	364	8	peptide	peptide	NOUN
admet-1272	364	9	.	.	PUNCT
admet-1272	365	1	j.	j.	PROPN
admet-1272	365	2	chem	chem	PROPN
admet-1272	365	3	.	.	PUNCT
admet-1272	366	1	soc	soc	PROPN
admet-1272	366	2	.	.	PUNCT
admet-1272	367	1	74	74	NUM
admet-1272	367	2	(	(	PUNCT
admet-1272	367	3	1952	1952	NUM
admet-1272	367	4	)	)	PUNCT
admet-1272	367	5	4019	4019	NUM
admet-1272	367	6	-	-	SYM
admet-1272	367	7	4023	4023	NUM
admet-1272	367	8	.	.	PUNCT
admet-1272	368	1	https://doi.org/10.1021/ja01136a014	https://doi.org/10.1021/ja01136a014	PROPN
admet-1272	368	2	.	.	PUNCT
admet-1272	369	1	[	[	X
admet-1272	369	2	28	28	NUM
admet-1272	369	3	]	]	X
admet-1272	369	4	g.f	g.f	PROPN
admet-1272	369	5	.	.	PROPN
admet-1272	369	6	gause	gause	PROPN
admet-1272	369	7	.	.	PUNCT
admet-1272	370	1	gramicidin	gramicidin	NOUN
admet-1272	370	2	s	s	PROPN
admet-1272	370	3	and	and	CCONJ
admet-1272	370	4	its	its	PRON
admet-1272	370	5	use	use	NOUN
admet-1272	370	6	in	in	ADP
admet-1272	370	7	the	the	DET
admet-1272	370	8	treatment	treatment	NOUN
admet-1272	370	9	of	of	ADP
admet-1272	370	10	infected	infected	ADJ
admet-1272	370	11	wounds	wound	NOUN
admet-1272	370	12	.	.	PUNCT
admet-1272	371	1	nature	nature	NOUN
admet-1272	371	2	154	154	NUM
admet-1272	371	3	(	(	PUNCT
admet-1272	371	4	1944	1944	NUM
admet-1272	371	5	)	)	PUNCT
admet-1272	371	6	703	703	NUM
admet-1272	371	7	.	.	PUNCT
admet-1272	372	1	https://doi.org/10.1038/154703a0	https://doi.org/10.1038/154703a0	PROPN
admet-1272	372	2	.	.	PUNCT
admet-1272	372	3	https://doi.org/10.1038/ja.2008.84	https://doi.org/10.1038/ja.2008.84	PROPN
admet-1272	372	4	https://doi.org/10.1002/anie.201304691	https://doi.org/10.1002/anie.201304691	PROPN
admet-1272	372	5	https://doi.org/10.1021/ja506472u	https://doi.org/10.1021/ja506472u	ADP
admet-1272	372	6	https://doi.org/10.1128/msphere.00156-20	https://doi.org/10.1128/msphere.00156-20	NOUN
admet-1272	372	7	https://doi.org/10.1021/acs.joc.6b01272	https://doi.org/10.1021/acs.joc.6b01272	NOUN
admet-1272	372	8	https://doi.org/10.1021/acsinfecdis.0c00031	https://doi.org/10.1021/acsinfecdis.0c00031	NOUN
admet-1272	372	9	https://doi.org/10.1016/s1473-3099(15)00424-7	https://doi.org/10.1016/s1473-3099(15)00424-7	PROPN
admet-1272	372	10	https://doi.org/10.1016/j.jgar.2021.07.021	https://doi.org/10.1016/j.jgar.2021.07.021	PROPN
admet-1272	372	11	https://doi.org/10.1016/j.jgar.2021.07.021	https://doi.org/10.1016/j.jgar.2021.07.021	PROPN
admet-1272	372	12	https://doi.org/10.1039/d1sc03460j	https://doi.org/10.1039/d1sc03460j	PROPN
admet-1272	372	13	https://doi.org/10.3389/fmicb.2019.01689	https://doi.org/10.3389/fmicb.2019.01689	PROPN
admet-1272	372	14	https://doi.org/10.1038/s41586-021-04264-x	https://doi.org/10.1038/s41586-021-04264-x	PROPN
admet-1272	372	15	https://doi.org/10.1038/s41586-021-04264-x	https://doi.org/10.1038/s41586-021-04264-x	PROPN
admet-1272	372	16	https://doi.org/10.1128/aac.33.2.192	https://doi.org/10.1128/aac.33.2.192	VERB
admet-1272	372	17	https://doi.org/10.1128/aac.00922-10	https://doi.org/10.1128/aac.00922-10	NOUN
admet-1272	373	1	https://doi.org/10.1021/acsinfecdis.1c00318	https://doi.org/10.1021/acsinfecdis.1c00318	CCONJ
admet-1272	373	2	https://doi.org/10.1021/ja01136a014	https://doi.org/10.1021/ja01136a014	PROPN
admet-1272	373	3	https://doi.org/10.1038/154703a0	https://doi.org/10.1038/154703a0	PROPN
admet-1272	373	4	admet	admet	PROPN
admet-1272	373	5	&	&	CCONJ
admet-1272	373	6	dmpk	dmpk	PROPN
admet-1272	373	7	10(2	10(2	NUM
admet-1272	373	8	)	)	PUNCT
admet-1272	373	9	(	(	PUNCT
admet-1272	373	10	2022	2022	NUM
admet-1272	373	11	)	)	PUNCT
admet-1272	373	12	131	131	NUM
admet-1272	373	13	-	-	SYM
admet-1272	373	14	146	146	NUM
admet-1272	373	15	chemical	chemical	NOUN
admet-1272	373	16	syntheses	synthesis	NOUN
admet-1272	373	17	and	and	CCONJ
admet-1272	373	18	resistant	resistant	ADJ
admet-1272	373	19	antibiotics	antibiotic	NOUN
admet-1272	373	20	doi	doi	NOUN
admet-1272	373	21	:	:	PUNCT
admet-1272	373	22	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	NOUN
admet-1272	373	23	145	145	NUM
admet-1272	373	24	[	[	X
admet-1272	373	25	29	29	NUM
admet-1272	373	26	]	]	X
admet-1272	373	27	g.f	g.f	PROPN
admet-1272	373	28	.	.	PROPN
admet-1272	373	29	gause	gause	PROPN
admet-1272	373	30	,	,	PUNCT
admet-1272	373	31	m.g	m.g	PROPN
admet-1272	373	32	.	.	PROPN
admet-1272	373	33	brazhnikova	brazhnikova	PROPN
admet-1272	373	34	.	.	PUNCT
admet-1272	374	1	gramicidn	gramicidn	PROPN
admet-1272	374	2	s	s	PART
admet-1272	374	3	origin	origin	NOUN
admet-1272	374	4	and	and	CCONJ
admet-1272	374	5	mode	mode	NOUN
admet-1272	374	6	of	of	ADP
admet-1272	374	7	action	action	NOUN
admet-1272	374	8	.	.	PUNCT
admet-1272	375	1	lancet	lancet	NOUN
admet-1272	375	2	244	244	NUM
admet-1272	375	3	(	(	PUNCT
admet-1272	375	4	1944	1944	NUM
admet-1272	375	5	)	)	PUNCT
admet-1272	375	6	715	715	NUM
admet-1272	375	7	-	-	SYM
admet-1272	375	8	716	716	NUM
admet-1272	375	9	.	.	PUNCT
admet-1272	375	10	https://doi.org/10.1016/s0140-6736(00)88377-4	https://doi.org/10.1016/s0140-6736(00)88377-4	NOUN
admet-1272	375	11	.	.	PUNCT
admet-1272	376	1	[	[	X
admet-1272	376	2	30	30	NUM
admet-1272	376	3	]	]	X
admet-1272	376	4	a.n	a.n	PROPN
admet-1272	376	5	.	.	PROPN
admet-1272	376	6	belozersky	belozersky	PROPN
admet-1272	376	7	,	,	PUNCT
admet-1272	376	8	t.s	t.s	PROPN
admet-1272	376	9	.	.	PROPN
admet-1272	376	10	passhina	passhina	PROPN
admet-1272	376	11	.	.	PUNCT
admet-1272	377	1	chemistry	chemistry	NOUN
admet-1272	377	2	of	of	ADP
admet-1272	377	3	gramacidin	gramacidin	PROPN
admet-1272	377	4	s.	s.	PROPN
admet-1272	377	5	lancet	lancet	PROPN
admet-1272	377	6	244	244	NUM
admet-1272	377	7	(	(	PUNCT
admet-1272	377	8	1944	1944	NUM
admet-1272	377	9	)	)	PUNCT
admet-1272	377	10	716	716	NUM
admet-1272	377	11	-	-	SYM
admet-1272	377	12	717	717	NUM
admet-1272	377	13	.	.	PUNCT
admet-1272	378	1	https://doi.org/10.1016/s0140-6736(00)88378-6	https://doi.org/10.1016/s0140-6736(00)88378-6	NOUN
admet-1272	378	2	.	.	PUNCT
admet-1272	379	1	[	[	X
admet-1272	379	2	31	31	NUM
admet-1272	379	3	]	]	X
admet-1272	379	4	p.g	p.g	PROPN
admet-1272	379	5	.	.	NOUN
admet-1272	379	6	sergiev	sergiev	PROPN
admet-1272	379	7	.	.	PUNCT
admet-1272	380	1	clinical	clinical	ADJ
admet-1272	380	2	use	use	NOUN
admet-1272	380	3	of	of	ADP
admet-1272	380	4	gramicidin	gramicidin	NOUN
admet-1272	380	5	s.	s.	PROPN
admet-1272	380	6	lancet	lancet	PROPN
admet-1272	380	7	244	244	NUM
admet-1272	380	8	(	(	PUNCT
admet-1272	380	9	1944	1944	NUM
admet-1272	380	10	)	)	PUNCT
admet-1272	380	11	717	717	NUM
admet-1272	380	12	-	-	SYM
admet-1272	380	13	718	718	NUM
admet-1272	380	14	.	.	PUNCT
admet-1272	381	1	https://doi.org/10.1016/s01406736(00)88379-8	https://doi.org/10.1016/s01406736(00)88379-8	X
admet-1272	381	2	.	.	PUNCT
admet-1272	382	1	[	[	X
admet-1272	382	2	32	32	NUM
admet-1272	382	3	]	]	X
admet-1272	382	4	g.f	g.f	PROPN
admet-1272	382	5	.	.	PROPN
admet-1272	382	6	gause	gause	PROPN
admet-1272	382	7	.	.	PUNCT
admet-1272	383	1	gramacidin	gramacidin	VERB
admet-1272	383	2	s	s	PRON
admet-1272	383	3	review	review	NOUN
admet-1272	383	4	of	of	ADP
admet-1272	383	5	recent	recent	ADJ
admet-1272	383	6	work	work	NOUN
admet-1272	383	7	.	.	PUNCT
admet-1272	384	1	lancet	lancet	NOUN
admet-1272	384	2	248	248	NUM
admet-1272	384	3	(	(	PUNCT
admet-1272	384	4	1946	1946	NUM
admet-1272	384	5	)	)	PUNCT
admet-1272	384	6	46	46	NUM
admet-1272	384	7	-	-	SYM
admet-1272	384	8	47	47	NUM
admet-1272	384	9	.	.	PUNCT
admet-1272	385	1	https://doi.org/10.1016/s0140-6736(46)90004-9	https://doi.org/10.1016/s0140-6736(46)90004-9	PROPN
admet-1272	385	2	.	.	PUNCT
admet-1272	386	1	[	[	X
admet-1272	386	2	33	33	NUM
admet-1272	386	3	]	]	X
admet-1272	386	4	b.p	b.p	PROPN
admet-1272	386	5	.	.	PROPN
admet-1272	386	6	lazzaro	lazzaro	PROPN
admet-1272	386	7	,	,	PUNCT
admet-1272	386	8	m.	m.	NOUN
admet-1272	386	9	zasloff	zasloff	PROPN
admet-1272	386	10	,	,	PUNCT
admet-1272	386	11	j.	j.	PROPN
admet-1272	386	12	rolff	rolff	PROPN
admet-1272	386	13	.	.	PUNCT
admet-1272	387	1	antimicrobial	antimicrobial	ADJ
admet-1272	387	2	peptides	peptide	NOUN
admet-1272	387	3	:	:	PUNCT
admet-1272	387	4	application	application	NOUN
admet-1272	387	5	informed	inform	VERB
admet-1272	387	6	by	by	ADP
admet-1272	387	7	evolution	evolution	NOUN
admet-1272	387	8	.	.	PUNCT
admet-1272	388	1	science	science	NOUN
admet-1272	388	2	368	368	NUM
admet-1272	388	3	(	(	PUNCT
admet-1272	388	4	2020	2020	NUM
admet-1272	388	5	)	)	PUNCT
admet-1272	388	6	eaau5480	eaau5480	PROPN
admet-1272	388	7	.	.	PUNCT
admet-1272	389	1	https://doi.org/10.1126/science.aau5480	https://doi.org/10.1126/science.aau5480	PROPN
admet-1272	389	2	.	.	PUNCT
admet-1272	390	1	[	[	X
admet-1272	390	2	34	34	NUM
admet-1272	390	3	]	]	X
admet-1272	390	4	j.	j.	PROPN
admet-1272	390	5	zerweck	zerweck	PROPN
admet-1272	390	6	,	,	PUNCT
admet-1272	390	7	e.	e.	PROPN
admet-1272	390	8	strandberg	strandberg	PROPN
admet-1272	390	9	,	,	PUNCT
admet-1272	390	10	o.	o.	PROPN
admet-1272	390	11	kukharenko	kukharenko	PROPN
admet-1272	390	12	,	,	PUNCT
admet-1272	390	13	r.	r.	PROPN
admet-1272	390	14	j.	j.	PROPN
admet-1272	390	15	,	,	PUNCT
admet-1272	390	16	j.	j.	PROPN
admet-1272	390	17	bürck	bürck	PROPN
admet-1272	390	18	,	,	PUNCT
admet-1272	390	19	p.	p.	PROPN
admet-1272	390	20	wadhwani	wadhwani	PROPN
admet-1272	390	21	,	,	PUNCT
admet-1272	390	22	a.s	a.s	PROPN
admet-1272	390	23	.	.	PROPN
admet-1272	390	24	ulrich	ulrich	PROPN
admet-1272	390	25	.	.	PUNCT
admet-1272	391	1	molecular	molecular	ADJ
admet-1272	391	2	mechanism	mechanism	NOUN
admet-1272	391	3	of	of	ADP
admet-1272	391	4	synergy	synergy	NOUN
admet-1272	391	5	between	between	ADP
admet-1272	391	6	the	the	DET
admet-1272	391	7	antimicrobial	antimicrobial	ADJ
admet-1272	391	8	peptides	peptide	NOUN
admet-1272	391	9	pgla	pgla	PROPN
admet-1272	391	10	and	and	CCONJ
admet-1272	391	11	magainin	magainin	NOUN
admet-1272	391	12	2	2	NUM
admet-1272	391	13	.	.	PUNCT
admet-1272	392	1	sci	sci	PROPN
admet-1272	392	2	.	.	PUNCT
admet-1272	392	3	rep	rep	PROPN
admet-1272	392	4	.	.	PROPN
admet-1272	392	5	7	7	NUM
admet-1272	392	6	(	(	PUNCT
admet-1272	392	7	2017	2017	NUM
admet-1272	392	8	)	)	PUNCT
admet-1272	392	9	13153	13153	NUM
admet-1272	392	10	.	.	PUNCT
admet-1272	393	1	https://doi.org/10.1038/s41598-017-12599-7	https://doi.org/10.1038/s41598-017-12599-7	PROPN
admet-1272	393	2	.	.	PUNCT
admet-1272	394	1	[	[	X
admet-1272	394	2	35	35	NUM
admet-1272	394	3	]	]	X
admet-1272	394	4	n.h.z	n.h.z	ADJ
admet-1272	394	5	.	.	PUNCT
admet-1272	394	6	baharin	baharin	PROPN
admet-1272	394	7	,	,	PUNCT
admet-1272	394	8	n.f.k	n.f.k	PROPN
admet-1272	394	9	.	.	PROPN
admet-1272	394	10	mokhtar	mokhtar	PROPN
admet-1272	394	11	,	,	PUNCT
admet-1272	394	12	m.	m.	NOUN
admet-1272	394	13	nasir	nasir	PROPN
admet-1272	394	14	,	,	PUNCT
admet-1272	394	15	m.	m.	NOUN
admet-1272	394	16	desa	desa	PROPN
admet-1272	394	17	,	,	PUNCT
admet-1272	394	18	b.	b.	PROPN
admet-1272	394	19	gopalsamy	gopalsamy	PROPN
admet-1272	394	20	,	,	PUNCT
admet-1272	394	21	n.n.m	n.n.m	NOUN
admet-1272	394	22	.	.	PUNCT
admet-1272	395	1	zaki	zaki	PROPN
admet-1272	395	2	,	,	PUNCT
admet-1272	395	3	m.h	m.h	PROPN
admet-1272	395	4	.	.	PROPN
admet-1272	395	5	yuswan	yuswan	PROPN
admet-1272	395	6	,	,	PUNCT
admet-1272	395	7	a.r	a.r	PROPN
admet-1272	395	8	.	.	PROPN
admet-1272	395	9	muthanna	muthanna	PROPN
admet-1272	395	10	,	,	PUNCT
admet-1272	395	11	n.d	n.d	PROPN
admet-1272	395	12	.	.	PROPN
admet-1272	395	13	dzaraly	dzaraly	PROPN
admet-1272	395	14	,	,	PUNCT
admet-1272	395	15	s.	s.	PROPN
admet-1272	395	16	abbasiliasi	abbasiliasi	PROPN
admet-1272	395	17	,	,	PUNCT
admet-1272	395	18	a.m.	a.m.	PROPN
admet-1272	396	1	hashim	hashim	PROPN
admet-1272	396	2	,	,	PUNCT
admet-1272	396	3	m.s.a	m.s.a	PROPN
admet-1272	396	4	.	.	PUNCT
admet-1272	396	5	sani	sani	PROPN
admet-1272	396	6	,	,	PUNCT
admet-1272	396	7	s.	s.	PROPN
admet-1272	396	8	mustafa	mustafa	PROPN
admet-1272	396	9	.	.	PUNCT
admet-1272	397	1	the	the	DET
admet-1272	397	2	characteristics	characteristic	NOUN
admet-1272	397	3	and	and	CCONJ
admet-1272	397	4	roles	role	NOUN
admet-1272	397	5	of	of	ADP
admet-1272	397	6	antimicrobial	antimicrobial	ADJ
admet-1272	397	7	peptides	peptide	NOUN
admet-1272	397	8	as	as	ADP
admet-1272	397	9	potential	potential	ADJ
admet-1272	397	10	treatment	treatment	NOUN
admet-1272	397	11	for	for	ADP
admet-1272	397	12	antibiotic	antibiotic	ADJ
admet-1272	397	13	-	-	PUNCT
admet-1272	397	14	resistant	resistant	ADJ
admet-1272	397	15	pathogens	pathogen	NOUN
admet-1272	397	16	:	:	PUNCT
admet-1272	397	17	a	a	DET
admet-1272	397	18	review	review	NOUN
admet-1272	397	19	.	.	PUNCT
admet-1272	398	1	peerj	peerj	PROPN
admet-1272	398	2	9	9	NUM
admet-1272	398	3	(	(	PUNCT
admet-1272	398	4	2021	2021	NUM
admet-1272	398	5	)	)	PUNCT
admet-1272	398	6	e12193	e12193	NOUN
admet-1272	398	7	.	.	PUNCT
admet-1272	399	1	https://doi.org/10.7717/peerj.12193	https://doi.org/10.7717/peerj.12193	NOUN
admet-1272	399	2	.	.	PUNCT
admet-1272	400	1	[	[	X
admet-1272	400	2	36	36	NUM
admet-1272	400	3	]	]	PUNCT
admet-1272	400	4	t.	t.	PROPN
admet-1272	400	5	vanzolini	vanzolini	PROPN
admet-1272	400	6	,	,	PUNCT
admet-1272	400	7	m.	m.	PROPN
admet-1272	400	8	bruschi	bruschi	PROPN
admet-1272	400	9	,	,	PUNCT
admet-1272	400	10	a.c	a.c	PROPN
admet-1272	400	11	.	.	PROPN
admet-1272	400	12	rinaldi	rinaldi	PROPN
admet-1272	400	13	,	,	PUNCT
admet-1272	400	14	m.	m.	NOUN
admet-1272	400	15	magnani	magnani	PROPN
admet-1272	400	16	,	,	PUNCT
admet-1272	400	17	a.	a.	NOUN
admet-1272	400	18	fraternale	fraternale	NOUN
admet-1272	400	19	.	.	PUNCT
admet-1272	401	1	multitalented	multitalented	ADJ
admet-1272	401	2	synthetic	synthetic	ADJ
admet-1272	401	3	antimicrobial	antimicrobial	ADJ
admet-1272	401	4	peptides	peptide	NOUN
admet-1272	401	5	and	and	CCONJ
admet-1272	401	6	their	their	PRON
admet-1272	401	7	antibacterial	antibacterial	ADJ
admet-1272	401	8	,	,	PUNCT
admet-1272	401	9	antifungal	antifungal	ADJ
admet-1272	401	10	and	and	CCONJ
admet-1272	401	11	antiviral	antiviral	ADJ
admet-1272	401	12	mechanisms	mechanism	NOUN
admet-1272	401	13	.	.	PUNCT
admet-1272	402	1	int	int	NOUN
admet-1272	402	2	.	.	PUNCT
admet-1272	403	1	j.	j.	PROPN
admet-1272	403	2	mol	mol	PROPN
admet-1272	403	3	.	.	PUNCT
admet-1272	404	1	sci	sci	PROPN
admet-1272	404	2	.	.	PROPN
admet-1272	405	1	23	23	NUM
admet-1272	405	2	(	(	PUNCT
admet-1272	405	3	2022	2022	NUM
admet-1272	405	4	)	)	PUNCT
admet-1272	405	5	545	545	NUM
admet-1272	405	6	.	.	PUNCT
admet-1272	406	1	https://doi.org/10.3390/ijms23010545	https://doi.org/10.3390/ijms23010545	PROPN
admet-1272	406	2	.	.	PUNCT
admet-1272	407	1	[	[	X
admet-1272	407	2	37	37	NUM
admet-1272	407	3	]	]	PUNCT
admet-1272	407	4	k.	k.	PROPN
admet-1272	407	5	klobucar	klobucar	PROPN
admet-1272	407	6	,	,	PUNCT
admet-1272	407	7	e.d	e.d	PROPN
admet-1272	407	8	.	.	PROPN
admet-1272	407	9	brown	brown	PROPN
admet-1272	407	10	.	.	PUNCT
admet-1272	408	1	new	new	ADJ
admet-1272	408	2	potentiators	potentiator	NOUN
admet-1272	408	3	of	of	ADP
admet-1272	408	4	ineffective	ineffective	ADJ
admet-1272	408	5	antibiotics	antibiotic	NOUN
admet-1272	408	6	:	:	PUNCT
admet-1272	408	7	targeting	target	VERB
admet-1272	408	8	the	the	DET
admet-1272	408	9	gram	gram	NOUN
admet-1272	408	10	-	-	PUNCT
admet-1272	408	11	negative	negative	ADJ
admet-1272	408	12	outer	outer	ADJ
admet-1272	408	13	membrane	membrane	NOUN
admet-1272	408	14	to	to	PART
admet-1272	408	15	overcome	overcome	VERB
admet-1272	408	16	intrinsic	intrinsic	ADJ
admet-1272	408	17	resistance	resistance	NOUN
admet-1272	408	18	.	.	PUNCT
admet-1272	409	1	curr	curr	PROPN
admet-1272	409	2	.	.	PUNCT
admet-1272	410	1	opin	opin	NOUN
admet-1272	410	2	.	.	PUNCT
admet-1272	411	1	chem	chem	NOUN
admet-1272	411	2	.	.	PUNCT
admet-1272	412	1	biol	biol	PROPN
admet-1272	412	2	.	.	PUNCT
admet-1272	413	1	66	66	NUM
admet-1272	413	2	(	(	PUNCT
admet-1272	413	3	2022	2022	NUM
admet-1272	413	4	)	)	PUNCT
admet-1272	413	5	102099	102099	NUM
admet-1272	413	6	.	.	PUNCT
admet-1272	414	1	https://doi.org/10.1016/j.cbpa.2021.102099	https://doi.org/10.1016/j.cbpa.2021.102099	PROPN
admet-1272	414	2	.	.	PUNCT
admet-1272	415	1	[	[	X
admet-1272	415	2	38	38	NUM
admet-1272	415	3	]	]	PUNCT
admet-1272	415	4	b.	b.	PROPN
admet-1272	415	5	gao	gao	PROPN
admet-1272	415	6	,	,	PUNCT
admet-1272	415	7	s.	s.	PROPN
admet-1272	415	8	chen	chen	PROPN
admet-1272	415	9	,	,	PUNCT
admet-1272	415	10	y.n	y.n	PROPN
admet-1272	415	11	.	.	PROPN
admet-1272	415	12	hou	hou	PROPN
admet-1272	415	13	,	,	PUNCT
admet-1272	415	14	y.j	y.j	PROPN
admet-1272	415	15	.	.	PUNCT
admet-1272	415	16	zhao	zhao	PROPN
admet-1272	415	17	,	,	PUNCT
admet-1272	415	18	t.	t.	PROPN
admet-1272	415	19	ye	ye	PROPN
admet-1272	415	20	,	,	PUNCT
admet-1272	415	21	z.	z.	PROPN
admet-1272	415	22	xu	xu	PROPN
admet-1272	415	23	.	.	PUNCT
admet-1272	415	24	solution	solution	NOUN
admet-1272	415	25	-	-	PUNCT
admet-1272	415	26	phase	phase	NOUN
admet-1272	415	27	total	total	ADJ
admet-1272	415	28	synthesis	synthesis	NOUN
admet-1272	415	29	of	of	ADP
admet-1272	415	30	teixobactin	teixobactin	ADJ
admet-1272	415	31	.	.	PUNCT
admet-1272	416	1	org	org	PROPN
admet-1272	416	2	.	.	PUNCT
admet-1272	416	3	biomol	biomol	PROPN
admet-1272	416	4	.	.	PUNCT
admet-1272	417	1	chem	chem	PROPN
admet-1272	417	2	.	.	PUNCT
admet-1272	418	1	17	17	NUM
admet-1272	418	2	(	(	PUNCT
admet-1272	418	3	2019	2019	NUM
admet-1272	418	4	)	)	PUNCT
admet-1272	418	5	1141	1141	NUM
admet-1272	418	6	-	-	SYM
admet-1272	418	7	1153	1153	NUM
admet-1272	418	8	.	.	PUNCT
admet-1272	419	1	https://doi.org/10.1039/c8ob02803f	https://doi.org/10.1039/c8ob02803f	PROPN
admet-1272	419	2	.	.	PUNCT
admet-1272	420	1	[	[	X
admet-1272	420	2	39	39	NUM
admet-1272	420	3	]	]	PUNCT
admet-1272	420	4	v.	v.	PROPN
admet-1272	420	5	ng	ng	PROPN
admet-1272	420	6	,	,	PUNCT
admet-1272	420	7	s.a	s.a	PROPN
admet-1272	420	8	.	.	PROPN
admet-1272	420	9	kuehne	kuehne	PROPN
admet-1272	420	10	,	,	PUNCT
admet-1272	420	11	w.c	w.c	PROPN
admet-1272	420	12	.	.	PROPN
admet-1272	420	13	chan	chan	PROPN
admet-1272	420	14	.	.	PUNCT
admet-1272	421	1	rational	rational	ADJ
admet-1272	421	2	design	design	NOUN
admet-1272	421	3	and	and	CCONJ
admet-1272	421	4	synthesis	synthesis	NOUN
admet-1272	421	5	of	of	ADP
admet-1272	421	6	modified	modify	VERB
admet-1272	421	7	teixobactin	teixobactin	ADJ
admet-1272	421	8	analogues	analogue	NOUN
admet-1272	421	9	:	:	PUNCT
admet-1272	421	10	in	in	ADP
admet-1272	421	11	vitro	vitro	X
admet-1272	421	12	antibacterial	antibacterial	ADJ
admet-1272	421	13	activity	activity	NOUN
admet-1272	421	14	against	against	ADP
admet-1272	421	15	staphylococcus	staphylococcus	NOUN
admet-1272	421	16	aureus	aureus	NOUN
admet-1272	421	17	,	,	PUNCT
admet-1272	421	18	propionibacterium	propionibacterium	NOUN
admet-1272	421	19	acnes	acne	NOUN
admet-1272	421	20	and	and	CCONJ
admet-1272	421	21	pseudomonas	pseudomona	NOUN
admet-1272	421	22	aeruginosa	aeruginosa	NOUN
admet-1272	421	23	.	.	PUNCT
admet-1272	422	1	chem	chem	NOUN
admet-1272	422	2	.	.	PUNCT
admet-1272	423	1	eur	eur	PROPN
admet-1272	423	2	.	.	PUNCT
admet-1272	424	1	j.	j.	PROPN
admet-1272	424	2	24	24	NUM
admet-1272	424	3	(	(	PUNCT
admet-1272	424	4	2018	2018	NUM
admet-1272	424	5	)	)	PUNCT
admet-1272	424	6	9136	9136	NUM
admet-1272	424	7	-	-	SYM
admet-1272	424	8	9147	9147	NUM
admet-1272	424	9	.	.	PUNCT
admet-1272	425	1	https://doi.org/10.1002/chem.201801423	https://doi.org/10.1002/chem.201801423	NOUN
admet-1272	425	2	.	.	PUNCT
admet-1272	426	1	[	[	X
admet-1272	426	2	40	40	NUM
admet-1272	426	3	]	]	PUNCT
admet-1272	426	4	z.	z.	PROPN
admet-1272	426	5	charlop	charlop	PROPN
admet-1272	426	6	-	-	PUNCT
admet-1272	426	7	powers	power	NOUN
admet-1272	426	8	,	,	PUNCT
admet-1272	426	9	a.	a.	PROPN
admet-1272	426	10	milshteyn	milshteyn	PROPN
admet-1272	426	11	,	,	PUNCT
admet-1272	426	12	s.f	s.f	PROPN
admet-1272	426	13	.	.	PROPN
admet-1272	426	14	brady	brady	PROPN
admet-1272	426	15	.	.	PUNCT
admet-1272	427	1	metagenomic	metagenomic	ADJ
admet-1272	427	2	small	small	ADJ
admet-1272	427	3	molecule	molecule	NOUN
admet-1272	427	4	discovery	discovery	NOUN
admet-1272	427	5	methods	method	NOUN
admet-1272	427	6	.	.	PUNCT
admet-1272	428	1	curr	curr	PROPN
admet-1272	428	2	.	.	PUNCT
admet-1272	429	1	opin	opin	NOUN
admet-1272	429	2	.	.	PUNCT
admet-1272	430	1	microbiol	microbiol	PROPN
admet-1272	430	2	.	.	PUNCT
admet-1272	431	1	19	19	NUM
admet-1272	431	2	(	(	PUNCT
admet-1272	431	3	2014	2014	NUM
admet-1272	431	4	)	)	PUNCT
admet-1272	431	5	70	70	NUM
admet-1272	431	6	-	-	SYM
admet-1272	431	7	75	75	NUM
admet-1272	431	8	.	.	PUNCT
admet-1272	432	1	https://doi.org/10.1016/j.mib.2014.05.021	https://doi.org/10.1016/j.mib.2014.05.021	NOUN
admet-1272	432	2	.	.	PUNCT
admet-1272	433	1	[	[	X
admet-1272	433	2	41	41	NUM
admet-1272	433	3	]	]	PUNCT
admet-1272	433	4	z.	z.	PROPN
admet-1272	433	5	charlop	charlop	PROPN
admet-1272	433	6	-	-	PUNCT
admet-1272	433	7	powers	power	NOUN
admet-1272	433	8	,	,	PUNCT
admet-1272	433	9	s.f	s.f	PROPN
admet-1272	433	10	.	.	PROPN
admet-1272	433	11	brady	brady	PROPN
admet-1272	433	12	.	.	PUNCT
admet-1272	434	1	phylogeo	phylogeo	PROPN
admet-1272	434	2	:	:	PUNCT
admet-1272	434	3	an	an	DET
admet-1272	434	4	r	r	NOUN
admet-1272	434	5	package	package	NOUN
admet-1272	434	6	for	for	ADP
admet-1272	434	7	geographic	geographic	ADJ
admet-1272	434	8	analysis	analysis	NOUN
admet-1272	434	9	and	and	CCONJ
admet-1272	434	10	visualization	visualization	NOUN
admet-1272	434	11	of	of	ADP
admet-1272	434	12	microbiome	microbiome	ADJ
admet-1272	434	13	data	datum	NOUN
admet-1272	434	14	.	.	PUNCT
admet-1272	435	1	bioinformatics	bioinformatic	NOUN
admet-1272	435	2	31	31	NUM
admet-1272	435	3	(	(	PUNCT
admet-1272	435	4	2015	2015	NUM
admet-1272	435	5	)	)	PUNCT
admet-1272	435	6	2909–2911	2909–2911	NUM
admet-1272	435	7	.	.	PUNCT
admet-1272	436	1	https://doi.org/10.1093/bioinformatics/btv269	https://doi.org/10.1093/bioinformatics/btv269	NOUN
admet-1272	436	2	.	.	PUNCT
admet-1272	437	1	[	[	X
admet-1272	437	2	42	42	NUM
admet-1272	437	3	]	]	PUNCT
admet-1272	437	4	z.	z.	PROPN
admet-1272	437	5	charlop	charlop	PROPN
admet-1272	437	6	-	-	PUNCT
admet-1272	437	7	powers	power	NOUN
admet-1272	437	8	,	,	PUNCT
admet-1272	437	9	c.c	c.c	PROPN
admet-1272	437	10	.	.	PROPN
admet-1272	437	11	pregitzer	pregitzer	PROPN
admet-1272	437	12	,	,	PUNCT
admet-1272	437	13	c.	c.	PROPN
admet-1272	437	14	lemetre	lemetre	PROPN
admet-1272	437	15	,	,	PUNCT
admet-1272	437	16	m.a	m.a	PROPN
admet-1272	437	17	.	.	PROPN
admet-1272	437	18	ternei	ternei	PROPN
admet-1272	437	19	,	,	PUNCT
admet-1272	437	20	j.	j.	PROPN
admet-1272	437	21	maniko	maniko	PROPN
admet-1272	437	22	,	,	PUNCT
admet-1272	437	23	b.m	b.m	PROPN
admet-1272	437	24	.	.	PROPN
admet-1272	437	25	hover	hover	PROPN
admet-1272	437	26	,	,	PUNCT
admet-1272	437	27	p.y	p.y	PROPN
admet-1272	437	28	.	.	PROPN
admet-1272	437	29	calle	calle	PROPN
admet-1272	437	30	,	,	PUNCT
admet-1272	437	31	k.l	k.l	PROPN
admet-1272	437	32	.	.	PROPN
admet-1272	437	33	mcguire	mcguire	PROPN
admet-1272	437	34	,	,	PUNCT
admet-1272	437	35	j.	j.	PROPN
admet-1272	437	36	garbarino	garbarino	PROPN
admet-1272	437	37	,	,	PUNCT
admet-1272	437	38	h.m	h.m	PROPN
admet-1272	437	39	.	.	PROPN
admet-1272	437	40	forgione	forgione	PROPN
admet-1272	437	41	,	,	PUNCT
admet-1272	437	42	s.	s.	PROPN
admet-1272	437	43	charlop	charlop	PROPN
admet-1272	437	44	-	-	PUNCT
admet-1272	437	45	powers	power	NOUN
admet-1272	437	46	,	,	PUNCT
admet-1272	437	47	s.f	s.f	PROPN
admet-1272	437	48	.	.	PROPN
admet-1272	437	49	brady	brady	PROPN
admet-1272	437	50	.	.	PUNCT
admet-1272	438	1	urban	urban	PROPN
admet-1272	438	2	park	park	PROPN
admet-1272	438	3	soil	soil	NOUN
admet-1272	438	4	microbiomes	microbiomes	PROPN
admet-1272	438	5	are	be	AUX
admet-1272	438	6	a	a	DET
admet-1272	438	7	rich	rich	ADJ
admet-1272	438	8	reservoir	reservoir	NOUN
admet-1272	438	9	of	of	ADP
admet-1272	438	10	natural	natural	ADJ
admet-1272	438	11	product	product	NOUN
admet-1272	438	12	biosynthetic	biosynthetic	ADJ
admet-1272	438	13	diversity	diversity	NOUN
admet-1272	438	14	.	.	PUNCT
admet-1272	439	1	proc	proc	PROPN
admet-1272	439	2	.	.	PUNCT
admet-1272	440	1	natl	natl	PROPN
admet-1272	440	2	.	.	PUNCT
admet-1272	441	1	acad	acad	PROPN
admet-1272	441	2	.	.	PUNCT
admet-1272	442	1	sci	sci	PROPN
admet-1272	442	2	.	.	PROPN
admet-1272	442	3	,	,	PUNCT
admet-1272	442	4	u.s.a	u.s.a	PROPN
admet-1272	442	5	.	.	PROPN
admet-1272	442	6	113	113	NUM
admet-1272	442	7	(	(	PUNCT
admet-1272	442	8	2016	2016	NUM
admet-1272	442	9	)	)	PUNCT
admet-1272	442	10	14811	14811	NUM
admet-1272	442	11	-	-	SYM
admet-1272	442	12	14816	14816	NUM
admet-1272	442	13	.	.	PUNCT
admet-1272	443	1	https://doi.org/10.1073/pnas.1615581113	https://doi.org/10.1073/pnas.1615581113	ADJ
admet-1272	443	2	.	.	PUNCT
admet-1272	444	1	[	[	X
admet-1272	444	2	43	43	NUM
admet-1272	444	3	]	]	PUNCT
admet-1272	444	4	x.	x.	PROPN
admet-1272	444	5	vila	vila	PROPN
admet-1272	444	6	-	-	PUNCT
admet-1272	444	7	farres	farres	PROPN
admet-1272	444	8	,	,	PUNCT
admet-1272	444	9	j.	j.	PROPN
admet-1272	444	10	chu	chu	PROPN
admet-1272	444	11	,	,	PUNCT
admet-1272	444	12	m.a	m.a	PROPN
admet-1272	444	13	.	.	PROPN
admet-1272	444	14	ternei	ternei	PROPN
admet-1272	444	15	,	,	PUNCT
admet-1272	444	16	c.	c.	PROPN
admet-1272	444	17	lemetre	lemetre	PROPN
admet-1272	444	18	,	,	PUNCT
admet-1272	444	19	s.	s.	PROPN
admet-1272	444	20	park	park	PROPN
admet-1272	444	21	,	,	PUNCT
admet-1272	444	22	d.s	d.s	PROPN
admet-1272	444	23	.	.	PROPN
admet-1272	444	24	perlin	perlin	PROPN
admet-1272	444	25	,	,	PUNCT
admet-1272	444	26	s.f	s.f	PROPN
admet-1272	444	27	.	.	PROPN
admet-1272	444	28	brady	brady	PROPN
admet-1272	444	29	.	.	PUNCT
admet-1272	445	1	an	an	DET
admet-1272	445	2	optimized	optimize	VERB
admet-1272	445	3	syntheticbioinformatic	syntheticbioinformatic	ADJ
admet-1272	445	4	natural	natural	ADJ
admet-1272	445	5	product	product	NOUN
admet-1272	445	6	antibiotic	antibiotic	NOUN
admet-1272	445	7	sterilizes	sterilize	VERB
admet-1272	445	8	multidrug	multidrug	NOUN
admet-1272	445	9	-	-	PUNCT
admet-1272	445	10	resistant	resistant	ADJ
admet-1272	445	11	acinetobacter	acinetobacter	ADV
admet-1272	445	12	baumanniiinfected	baumanniiinfecte	VERB
admet-1272	445	13	wounds	wound	NOUN
admet-1272	445	14	.	.	PUNCT
admet-1272	446	1	msphere	msphere	PROPN
admet-1272	446	2	3	3	NUM
admet-1272	446	3	(	(	PUNCT
admet-1272	446	4	2018	2018	NUM
admet-1272	446	5	)	)	PUNCT
admet-1272	446	6	3	3	NUM
admet-1272	446	7	:	:	PUNCT
admet-1272	446	8	e00528	e00528	PROPN
admet-1272	446	9	-	-	PUNCT
admet-1272	446	10	00517	00517	NUM
admet-1272	446	11	.	.	PUNCT
admet-1272	447	1	https://doi.org/10.1128/msphere.00528-17	https://doi.org/10.1128/msphere.00528-17	NOUN
admet-1272	447	2	.	.	PUNCT
admet-1272	448	1	[	[	X
admet-1272	448	2	44	44	NUM
admet-1272	448	3	]	]	PUNCT
admet-1272	448	4	j.	j.	PROPN
admet-1272	448	5	chu	chu	PROPN
admet-1272	448	6	,	,	PUNCT
admet-1272	448	7	b.	b.	PROPN
admet-1272	448	8	koirala	koirala	PROPN
admet-1272	448	9	,	,	PUNCT
admet-1272	448	10	n.	n.	PROPN
admet-1272	448	11	forelli	forelli	PROPN
admet-1272	448	12	,	,	PUNCT
admet-1272	448	13	x.	x.	PROPN
admet-1272	448	14	vila	vila	PROPN
admet-1272	448	15	-	-	PUNCT
admet-1272	448	16	farres	farre	NOUN
admet-1272	448	17	,	,	PUNCT
admet-1272	448	18	m.a	m.a	PROPN
admet-1272	448	19	.	.	PROPN
admet-1272	448	20	ternei	ternei	PROPN
admet-1272	448	21	,	,	PUNCT
admet-1272	448	22	t.	t.	PROPN
admet-1272	448	23	ali	ali	PROPN
admet-1272	448	24	,	,	PUNCT
admet-1272	448	25	d.a	d.a	PROPN
admet-1272	448	26	.	.	PROPN
admet-1272	448	27	colosimo	colosimo	PROPN
admet-1272	448	28	,	,	PUNCT
admet-1272	448	29	s.f	s.f	PROPN
admet-1272	448	30	.	.	PROPN
admet-1272	448	31	brady	brady	PROPN
admet-1272	448	32	.	.	PUNCT
admet-1272	449	1	syntheticbioinformatic	syntheticbioinformatic	ADJ
admet-1272	449	2	natural	natural	ADJ
admet-1272	449	3	product	product	NOUN
admet-1272	449	4	antibiotics	antibiotic	NOUN
admet-1272	449	5	with	with	ADP
admet-1272	449	6	diverse	diverse	ADJ
admet-1272	449	7	modes	mode	NOUN
admet-1272	449	8	of	of	ADP
admet-1272	449	9	action	action	NOUN
admet-1272	449	10	.	.	PUNCT
admet-1272	450	1	j.	j.	PROPN
admet-1272	450	2	am	am	PROPN
admet-1272	450	3	.	.	PUNCT
admet-1272	451	1	chem	chem	NOUN
admet-1272	451	2	.	.	PUNCT
admet-1272	452	1	soc	soc	PROPN
admet-1272	452	2	.	.	PUNCT
admet-1272	453	1	142	142	NUM
admet-1272	453	2	(	(	PUNCT
admet-1272	453	3	2020	2020	NUM
admet-1272	453	4	)	)	PUNCT
admet-1272	453	5	14158	14158	NUM
admet-1272	453	6	-	-	SYM
admet-1272	453	7	14168	14168	NUM
admet-1272	453	8	.	.	PUNCT
admet-1272	454	1	https://doi.org/10.1021/jacs.0c04376	https://doi.org/10.1021/jacs.0c04376	NOUN
admet-1272	454	2	.	.	PUNCT
admet-1272	455	1	[	[	X
admet-1272	455	2	45	45	NUM
admet-1272	455	3	]	]	X
admet-1272	455	4	b.m	b.m	PROPN
admet-1272	455	5	.	.	PROPN
admet-1272	455	6	hover	hover	PROPN
admet-1272	455	7	,	,	PUNCT
admet-1272	455	8	s.-h	s.-h	NOUN
admet-1272	455	9	.	.	PUNCT
admet-1272	456	1	kim	kim	PROPN
admet-1272	456	2	,	,	PUNCT
admet-1272	456	3	m.	m.	PROPN
admet-1272	456	4	katz	katz	PROPN
admet-1272	456	5	,	,	PUNCT
admet-1272	456	6	z.	z.	PROPN
admet-1272	456	7	charlop	charlop	PROPN
admet-1272	456	8	-	-	PUNCT
admet-1272	456	9	powers	power	NOUN
admet-1272	456	10	,	,	PUNCT
admet-1272	456	11	j.g	j.g	PROPN
admet-1272	456	12	.	.	PROPN
admet-1272	456	13	owen	owen	PROPN
admet-1272	456	14	,	,	PUNCT
admet-1272	456	15	m.a	m.a	PROPN
admet-1272	456	16	.	.	PROPN
admet-1272	456	17	ternei	ternei	PROPN
admet-1272	456	18	,	,	PUNCT
admet-1272	456	19	j.	j.	PROPN
admet-1272	456	20	maniko	maniko	PROPN
admet-1272	456	21	,	,	PUNCT
admet-1272	456	22	a.	a.	NOUN
admet-1272	456	23	estrela	estrela	PROPN
admet-1272	456	24	,	,	PUNCT
admet-1272	456	25	b.	b.	PROPN
admet-1272	456	26	,	,	PUNCT
admet-1272	456	27	h.	h.	PROPN
admet-1272	456	28	molina	molina	PROPN
admet-1272	456	29	,	,	PUNCT
admet-1272	456	30	s.	s.	PROPN
admet-1272	456	31	park	park	PROPN
admet-1272	456	32	,	,	PUNCT
admet-1272	456	33	d.s	d.s	PROPN
admet-1272	456	34	.	.	PROPN
admet-1272	456	35	perlin	perlin	PROPN
admet-1272	456	36	,	,	PUNCT
admet-1272	456	37	s.f	s.f	PROPN
admet-1272	456	38	.	.	PROPN
admet-1272	456	39	brady	brady	PROPN
admet-1272	456	40	.	.	PUNCT
admet-1272	457	1	culture	culture	NOUN
admet-1272	457	2	-	-	PUNCT
admet-1272	457	3	independent	independent	ADJ
admet-1272	457	4	discovery	discovery	NOUN
admet-1272	457	5	of	of	ADP
admet-1272	457	6	the	the	DET
admet-1272	457	7	malacidins	malacidin	NOUN
admet-1272	457	8	as	as	ADP
admet-1272	457	9	calciumdependent	calciumdependent	NOUN
admet-1272	457	10	antibiotics	antibiotic	NOUN
admet-1272	457	11	with	with	ADP
admet-1272	457	12	activity	activity	NOUN
admet-1272	457	13	against	against	ADP
admet-1272	457	14	multidrug	multidrug	NOUN
admet-1272	457	15	-	-	PUNCT
admet-1272	457	16	resistant	resistant	ADJ
admet-1272	457	17	gram	gram	NOUN
admet-1272	457	18	-	-	PUNCT
admet-1272	457	19	positive	positive	ADJ
admet-1272	457	20	pathogens	pathogen	NOUN
admet-1272	457	21	.	.	PUNCT
admet-1272	458	1	nat	nat	PROPN
admet-1272	458	2	.	.	PUNCT
admet-1272	459	1	microbiol	microbiol	PROPN
admet-1272	459	2	.	.	PUNCT
admet-1272	460	1	3	3	NUM
admet-1272	460	2	(	(	PUNCT
admet-1272	460	3	2018	2018	NUM
admet-1272	460	4	)	)	PUNCT
admet-1272	460	5	415	415	NUM
admet-1272	460	6	-	-	SYM
admet-1272	460	7	422	422	NUM
admet-1272	460	8	.	.	PUNCT
admet-1272	461	1	https://doi.org/10.1038/s41564-018-0110-1	https://doi.org/10.1038/s41564-018-0110-1	PROPN
admet-1272	461	2	.	.	PUNCT
admet-1272	462	1	[	[	X
admet-1272	462	2	46	46	NUM
admet-1272	462	3	]	]	PUNCT
admet-1272	462	4	z.	z.	PROPN
admet-1272	462	5	sun	sun	PROPN
admet-1272	462	6	,	,	PUNCT
admet-1272	462	7	z.	z.	PROPN
admet-1272	462	8	shang	shang	PROPN
admet-1272	462	9	,	,	PUNCT
admet-1272	462	10	n.	n.	PROPN
admet-1272	462	11	forelli	forelli	PROPN
admet-1272	462	12	,	,	PUNCT
admet-1272	462	13	k.h.l	k.h.l	PROPN
admet-1272	462	14	.	.	PROPN
admet-1272	462	15	po	po	PROPN
admet-1272	462	16	,	,	PUNCT
admet-1272	462	17	s.	s.	PROPN
admet-1272	462	18	chen	chen	PROPN
admet-1272	462	19	,	,	PUNCT
admet-1272	462	20	s.f	s.f	PROPN
admet-1272	462	21	.	.	PROPN
admet-1272	462	22	brady	brady	PROPN
admet-1272	462	23	,	,	PUNCT
admet-1272	462	24	x.	x.	PROPN
admet-1272	462	25	li	li	PROPN
admet-1272	462	26	.	.	PROPN
admet-1272	462	27	total	total	ADJ
admet-1272	462	28	synthesis	synthesis	NOUN
admet-1272	462	29	of	of	ADP
admet-1272	462	30	malacidin	malacidin	NOUN
admet-1272	462	31	a	a	PRON
admet-1272	462	32	by	by	ADP
admet-1272	462	33	betahydroxyaspartic	betahydroxyaspartic	ADJ
admet-1272	462	34	acid	acid	NOUN
admet-1272	462	35	ligation	ligation	NOUN
admet-1272	462	36	-	-	PUNCT
admet-1272	462	37	mediated	mediate	VERB
admet-1272	462	38	cyclization	cyclization	NOUN
admet-1272	462	39	and	and	CCONJ
admet-1272	462	40	absolute	absolute	ADJ
admet-1272	462	41	structure	structure	NOUN
admet-1272	462	42	establishment	establishment	NOUN
admet-1272	462	43	.	.	PUNCT
admet-1272	463	1	angew	angew	PROPN
admet-1272	463	2	.	.	PUNCT
admet-1272	464	1	chem	chem	PROPN
admet-1272	464	2	.	.	PUNCT
admet-1272	465	1	int	int	NOUN
admet-1272	465	2	.	.	PUNCT
admet-1272	466	1	ed	ed	NOUN
admet-1272	466	2	.	.	PROPN
admet-1272	467	1	59	59	NUM
admet-1272	467	2	(	(	PUNCT
admet-1272	467	3	2020	2020	NUM
admet-1272	467	4	)	)	PUNCT
admet-1272	467	5	19868–19872	19868–19872	NUM
admet-1272	467	6	.	.	PUNCT
admet-1272	468	1	https://doi.org/10.1002/anie.202009092	https://doi.org/10.1002/anie.202009092	X
admet-1272	468	2	.	.	PUNCT
admet-1272	468	3	http://dx.doi.org/10.5599/admet.1272	http://dx.doi.org/10.5599/admet.1272	AUX
admet-1272	468	4	https://doi.org/10.1016/s0140-6736(00)88377-4	https://doi.org/10.1016/s0140-6736(00)88377-4	PROPN
admet-1272	468	5	https://doi.org/10.1016/s0140-6736(00)88378-6	https://doi.org/10.1016/s0140-6736(00)88378-6	NOUN
admet-1272	468	6	https://doi.org/10.1016/s0140-6736(00)88379-8	https://doi.org/10.1016/s0140-6736(00)88379-8	NOUN
admet-1272	468	7	https://doi.org/10.1016/s0140-6736(00)88379-8	https://doi.org/10.1016/s0140-6736(00)88379-8	VERB
admet-1272	468	8	https://doi.org/10.1016/s0140-6736(46)90004-9	https://doi.org/10.1016/s0140-6736(46)90004-9	ADJ
admet-1272	468	9	https://doi.org/10.1016/s0140-6736(46)90004-9	https://doi.org/10.1016/s0140-6736(46)90004-9	ADJ
admet-1272	468	10	https://doi.org/10.1126/science.aau5480	https://doi.org/10.1126/science.aau5480	PROPN
admet-1272	468	11	https://doi.org/10.1038/s41598-017-12599-7	https://doi.org/10.1038/s41598-017-12599-7	NUM
admet-1272	468	12	https://doi.org/10.7717/peerj.12193	https://doi.org/10.7717/peerj.12193	NOUN
admet-1272	468	13	https://doi.org/10.3390/ijms23010545	https://doi.org/10.3390/ijms23010545	PROPN
admet-1272	468	14	https://doi.org/10.1016/j.cbpa.2021.102099	https://doi.org/10.1016/j.cbpa.2021.102099	PROPN
admet-1272	468	15	https://doi.org/10.1039/c8ob02803f	https://doi.org/10.1039/c8ob02803f	PROPN
admet-1272	468	16	https://doi.org/10.1002/chem.201801423	https://doi.org/10.1002/chem.201801423	ADJ
admet-1272	468	17	https://doi.org/10.1016/j.mib.2014.05.021	https://doi.org/10.1016/j.mib.2014.05.021	PROPN
admet-1272	468	18	https://doi.org/10.1093/bioinformatics/btv269	https://doi.org/10.1093/bioinformatics/btv269	PROPN
admet-1272	468	19	https://doi.org/10.1093/bioinformatics/btv269	https://doi.org/10.1093/bioinformatics/btv269	PROPN
admet-1272	468	20	https://doi.org/10.1073/pnas.1615581113	https://doi.org/10.1073/pnas.1615581113	ADJ
admet-1272	468	21	https://doi.org/10.1128/msphere.00528-17	https://doi.org/10.1128/msphere.00528-17	PROPN
admet-1272	468	22	https://doi.org/10.1021/jacs.0c04376	https://doi.org/10.1021/jacs.0c04376	PROPN
admet-1272	468	23	https://doi.org/10.1038/s41564-018-0110-1	https://doi.org/10.1038/s41564-018-0110-1	PROPN
admet-1272	468	24	https://doi.org/10.1002/anie.202009092	https://doi.org/10.1002/anie.202009092	NOUN
admet-1272	468	25	david	david	PROPN
admet-1272	468	26	j.	j.	PROPN
admet-1272	468	27	newman	newman	PROPN
admet-1272	468	28	admet	admet	PROPN
admet-1272	468	29	&	&	CCONJ
admet-1272	468	30	dmpk	dmpk	PROPN
admet-1272	468	31	10(2	10(2	NUM
admet-1272	468	32	)	)	PUNCT
admet-1272	468	33	(	(	PUNCT
admet-1272	468	34	2022	2022	NUM
admet-1272	468	35	)	)	PUNCT
admet-1272	468	36	131	131	NUM
admet-1272	468	37	-	-	SYM
admet-1272	468	38	146	146	NUM
admet-1272	468	39	146	146	NUM
admet-1272	468	40	[	[	X
admet-1272	468	41	47	47	NUM
admet-1272	468	42	]	]	X
admet-1272	468	43	n.	n.	PROPN
admet-1272	468	44	kovalenko	kovalenko	PROPN
admet-1272	468	45	,	,	PUNCT
admet-1272	468	46	g.k	g.k	PROPN
admet-1272	468	47	.	.	PROPN
admet-1272	468	48	howard	howard	PROPN
admet-1272	468	49	,	,	PUNCT
admet-1272	468	50	j.a	j.a	PROPN
admet-1272	468	51	.	.	PROPN
admet-1272	468	52	swain	swain	PROPN
admet-1272	468	53	,	,	PUNCT
admet-1272	468	54	y.	y.	PROPN
admet-1272	468	55	hermant	hermant	PROPN
admet-1272	468	56	,	,	PUNCT
admet-1272	468	57	a.j	a.j	PROPN
admet-1272	468	58	.	.	PROPN
admet-1272	468	59	cameron	cameron	PROPN
admet-1272	468	60	,	,	PUNCT
admet-1272	468	61	g.m	g.m	PROPN
admet-1272	468	62	.	.	PROPN
admet-1272	468	63	cook	cook	PROPN
admet-1272	468	64	,	,	PUNCT
admet-1272	468	65	s.a	s.a	PROPN
admet-1272	468	66	.	.	PROPN
admet-1272	468	67	ferguson	ferguson	PROPN
admet-1272	468	68	,	,	PUNCT
admet-1272	468	69	l.a	l.a	PROPN
admet-1272	468	70	.	.	PROPN
admet-1272	468	71	stubbing	stubbing	NOUN
admet-1272	468	72	,	,	PUNCT
admet-1272	468	73	p.w.a	p.w.a	PROPN
admet-1272	469	1	.	.	PUNCT
admet-1272	469	2	harris	harris	PROPN
admet-1272	469	3	,	,	PUNCT
admet-1272	469	4	m.a	m.a	PROPN
admet-1272	469	5	.	.	PROPN
admet-1272	469	6	brimble	brimble	PROPN
admet-1272	469	7	.	.	PUNCT
admet-1272	470	1	a	a	DET
admet-1272	470	2	concise	concise	ADJ
admet-1272	470	3	synthetic	synthetic	ADJ
admet-1272	470	4	strategy	strategy	NOUN
admet-1272	470	5	towards	towards	ADP
admet-1272	470	6	the	the	DET
admet-1272	470	7	novel	novel	ADJ
admet-1272	470	8	calciumdependent	calciumdependent	NOUN
admet-1272	470	9	lipopeptide	lipopeptide	NOUN
admet-1272	470	10	antibiotic	antibiotic	ADJ
admet-1272	470	11	,	,	PUNCT
admet-1272	470	12	malacidin	malacidin	VERB
admet-1272	470	13	a	a	PRON
admet-1272	470	14	and	and	CCONJ
admet-1272	470	15	analogues	analogue	NOUN
admet-1272	470	16	.	.	PUNCT
admet-1272	471	1	front	front	ADJ
admet-1272	471	2	.	.	PUNCT
admet-1272	472	1	chem	chem	NOUN
admet-1272	472	2	.	.	PUNCT
admet-1272	473	1	9	9	NUM
admet-1272	473	2	(	(	PUNCT
admet-1272	473	3	2021	2021	NUM
admet-1272	473	4	)	)	PUNCT
admet-1272	473	5	687875	687875	NUM
admet-1272	473	6	.	.	PUNCT
admet-1272	474	1	https://doi.org/10.3389/fchem.2021.687875	https://doi.org/10.3389/fchem.2021.687875	PROPN
admet-1272	474	2	.	.	PUNCT
admet-1272	475	1	[	[	X
admet-1272	475	2	48	48	NUM
admet-1272	475	3	]	]	X
admet-1272	475	4	g.	g.	PROPN
admet-1272	475	5	upert	upert	PROPN
admet-1272	475	6	,	,	PUNCT
admet-1272	475	7	a.	a.	PROPN
admet-1272	475	8	luther	luther	PROPN
admet-1272	475	9	,	,	PUNCT
admet-1272	475	10	d.	d.	PROPN
admet-1272	475	11	obrecht	obrecht	PROPN
admet-1272	475	12	,	,	PUNCT
admet-1272	475	13	p.	p.	PROPN
admet-1272	475	14	ermert	ermert	NOUN
admet-1272	475	15	.	.	PUNCT
admet-1272	476	1	emerging	emerge	VERB
admet-1272	476	2	peptide	peptide	NOUN
admet-1272	476	3	antibiotics	antibiotic	NOUN
admet-1272	476	4	with	with	ADP
admet-1272	476	5	therapeutic	therapeutic	ADJ
admet-1272	476	6	potential	potential	NOUN
admet-1272	476	7	.	.	PUNCT
admet-1272	477	1	medicine	medicine	NOUN
admet-1272	477	2	drug	drug	NOUN
admet-1272	477	3	discov	discov	NOUN
admet-1272	477	4	.	.	PUNCT
admet-1272	478	1	9	9	NUM
admet-1272	478	2	(	(	PUNCT
admet-1272	478	3	2021	2021	NUM
admet-1272	478	4	)	)	PUNCT
admet-1272	478	5	100078	100078	NUM
admet-1272	478	6	.	.	PUNCT
admet-1272	479	1	https://doi.org/10.1016/j.medidd.2020.100078	https://doi.org/10.1016/j.medidd.2020.100078	NOUN
admet-1272	479	2	.	.	PUNCT
admet-1272	480	1	[	[	X
admet-1272	480	2	49	49	X
admet-1272	480	3	]	]	X
admet-1272	480	4	y.	y.	PROPN
admet-1272	480	5	liu	liu	PROPN
admet-1272	480	6	,	,	PUNCT
admet-1272	480	7	j.	j.	PROPN
admet-1272	480	8	shi	shi	PROPN
admet-1272	480	9	,	,	PUNCT
admet-1272	480	10	z.	z.	PROPN
admet-1272	480	11	tong	tong	PROPN
admet-1272	480	12	,	,	PUNCT
admet-1272	480	13	y.	y.	PROPN
admet-1272	480	14	jia	jia	PROPN
admet-1272	480	15	,	,	PUNCT
admet-1272	480	16	b.	b.	PROPN
admet-1272	480	17	yang	yang	PROPN
admet-1272	480	18	,	,	PUNCT
admet-1272	480	19	z.	z.	PROPN
admet-1272	480	20	wang	wang	PROPN
admet-1272	480	21	.	.	PUNCT
admet-1272	481	1	the	the	DET
admet-1272	481	2	revitalization	revitalization	NOUN
admet-1272	481	3	of	of	ADP
admet-1272	481	4	antimicrobial	antimicrobial	ADJ
admet-1272	481	5	peptides	peptide	NOUN
admet-1272	481	6	in	in	ADP
admet-1272	481	7	the	the	DET
admet-1272	481	8	resistance	resistance	NOUN
admet-1272	481	9	era	era	NOUN
admet-1272	481	10	.	.	PUNCT
admet-1272	482	1	pharmacol	pharmacol	PROPN
admet-1272	482	2	.	.	PUNCT
admet-1272	483	1	res	re	NOUN
admet-1272	483	2	.	.	PROPN
admet-1272	484	1	163	163	NUM
admet-1272	484	2	(	(	PUNCT
admet-1272	484	3	2021	2021	NUM
admet-1272	484	4	)	)	PUNCT
admet-1272	484	5	105276	105276	NUM
admet-1272	484	6	.	.	PUNCT
admet-1272	485	1	https://doi.org/10.1016/j.phrs.2020.105276	https://doi.org/10.1016/j.phrs.2020.105276	NOUN
admet-1272	485	2	.	.	PUNCT
admet-1272	486	1	[	[	X
admet-1272	486	2	50	50	NUM
admet-1272	486	3	]	]	X
admet-1272	486	4	y.	y.	PROPN
admet-1272	486	5	zhu	zhu	PROPN
admet-1272	486	6	,	,	PUNCT
admet-1272	486	7	w.	w.	PROPN
admet-1272	486	8	hao	hao	PROPN
admet-1272	486	9	,	,	PUNCT
admet-1272	486	10	x.	x.	PROPN
admet-1272	486	11	wang	wang	PROPN
admet-1272	486	12	,	,	PUNCT
admet-1272	486	13	j.	j.	PROPN
admet-1272	486	14	ouyang	ouyang	PROPN
admet-1272	486	15	,	,	PUNCT
admet-1272	486	16	x.	x.	PROPN
admet-1272	486	17	deng	deng	PROPN
admet-1272	486	18	,	,	PUNCT
admet-1272	486	19	h.	h.	PROPN
admet-1272	486	20	yu	yu	PROPN
admet-1272	486	21	,	,	PUNCT
admet-1272	486	22	y.	y.	PROPN
admet-1272	486	23	wang	wang	PROPN
admet-1272	486	24	.	.	PUNCT
admet-1272	487	1	antimicrobial	antimicrobial	ADJ
admet-1272	487	2	peptides	peptide	NOUN
admet-1272	487	3	,	,	PUNCT
admet-1272	487	4	conventional	conventional	ADJ
admet-1272	487	5	antibiotics	antibiotic	NOUN
admet-1272	487	6	,	,	PUNCT
admet-1272	487	7	and	and	CCONJ
admet-1272	487	8	their	their	PRON
admet-1272	487	9	synergistic	synergistic	ADJ
admet-1272	487	10	utility	utility	NOUN
admet-1272	487	11	for	for	ADP
admet-1272	487	12	the	the	DET
admet-1272	487	13	treatment	treatment	NOUN
admet-1272	487	14	of	of	ADP
admet-1272	487	15	drug‐resistant	drug‐resistant	NOUN
admet-1272	487	16	infections	infection	NOUN
admet-1272	487	17	.	.	PUNCT
admet-1272	488	1	med	med	PROPN
admet-1272	488	2	.	.	PUNCT
admet-1272	489	1	res	re	NOUN
admet-1272	489	2	.	.	PUNCT
admet-1272	490	1	rev	rev	PROPN
admet-1272	490	2	.	.	PROPN
admet-1272	491	1	(	(	PUNCT
admet-1272	491	2	2022	2022	NUM
admet-1272	491	3	)	)	PUNCT
admet-1272	491	4	.	.	PUNCT
admet-1272	492	1	https://doi.org/10.1002/med.21879	https://doi.org/10.1002/med.21879	VERB
admet-1272	492	2	.	.	PUNCT
admet-1272	493	1	[	[	X
admet-1272	493	2	51	51	NUM
admet-1272	493	3	]	]	X
admet-1272	493	4	k.c	k.c	PROPN
admet-1272	493	5	.	.	PROPN
admet-1272	493	6	nicolaou	nicolaou	PROPN
admet-1272	493	7	,	,	PUNCT
admet-1272	493	8	s.	s.	PROPN
admet-1272	493	9	rigol	rigol	PROPN
admet-1272	493	10	.	.	PUNCT
admet-1272	494	1	perspectives	perspective	NOUN
admet-1272	494	2	from	from	ADP
admet-1272	494	3	nearly	nearly	ADV
admet-1272	494	4	five	five	NUM
admet-1272	494	5	decades	decade	NOUN
admet-1272	494	6	of	of	ADP
admet-1272	494	7	total	total	ADJ
admet-1272	494	8	synthesis	synthesis	NOUN
admet-1272	494	9	of	of	ADP
admet-1272	494	10	natural	natural	ADJ
admet-1272	494	11	products	product	NOUN
admet-1272	494	12	and	and	CCONJ
admet-1272	494	13	their	their	PRON
admet-1272	494	14	analogues	analogue	NOUN
admet-1272	494	15	for	for	ADP
admet-1272	494	16	biology	biology	NOUN
admet-1272	494	17	and	and	CCONJ
admet-1272	494	18	medicine	medicine	NOUN
admet-1272	494	19	.	.	PUNCT
admet-1272	495	1	nat	nat	PROPN
admet-1272	495	2	.	.	PUNCT
admet-1272	496	1	prod	prod	PROPN
admet-1272	496	2	.	.	PUNCT
admet-1272	497	1	rep	rep	PROPN
admet-1272	497	2	.	.	PROPN
admet-1272	497	3	37	37	NUM
admet-1272	497	4	(	(	PUNCT
admet-1272	497	5	2020	2020	NUM
admet-1272	497	6	)	)	PUNCT
admet-1272	497	7	1404	1404	NUM
admet-1272	497	8	-	-	SYM
admet-1272	497	9	1435	1435	NUM
admet-1272	497	10	.	.	PUNCT
admet-1272	498	1	https://doi.org/10.1039/d0np00003e	https://doi.org/10.1039/d0np00003e	NOUN
admet-1272	498	2	.	.	PUNCT
admet-1272	499	1	[	[	X
admet-1272	499	2	52	52	NUM
admet-1272	499	3	]	]	X
admet-1272	499	4	p.a	p.a	PROPN
admet-1272	499	5	.	.	PROPN
admet-1272	499	6	wender	wender	PROPN
admet-1272	499	7	,	,	PUNCT
admet-1272	499	8	c.t	c.t	PROPN
admet-1272	499	9	.	.	PROPN
admet-1272	499	10	hardman	hardman	PROPN
admet-1272	499	11	,	,	PUNCT
admet-1272	499	12	s.	s.	PROPN
admet-1272	499	13	ho	ho	PROPN
admet-1272	499	14	,	,	PUNCT
admet-1272	499	15	m.s	m.s	PROPN
admet-1272	499	16	.	.	PROPN
admet-1272	499	17	jeffreys	jeffreys	PROPN
admet-1272	499	18	,	,	PUNCT
admet-1272	499	19	j.k	j.k	PROPN
admet-1272	499	20	.	.	PROPN
admet-1272	499	21	maclaren	maclaren	PROPN
admet-1272	499	22	,	,	PUNCT
admet-1272	499	23	r.v	r.v	PROPN
admet-1272	499	24	.	.	PROPN
admet-1272	499	25	quiroz	quiroz	PROPN
admet-1272	499	26	,	,	PUNCT
admet-1272	499	27	s.m	s.m	PROPN
admet-1272	499	28	.	.	PROPN
admet-1272	499	29	ryckbosch	ryckbosch	PROPN
admet-1272	499	30	,	,	PUNCT
admet-1272	499	31	a.j	a.j	PROPN
admet-1272	499	32	.	.	PROPN
admet-1272	499	33	shimizu	shimizu	PROPN
admet-1272	499	34	,	,	PUNCT
admet-1272	499	35	j.l	j.l	PROPN
admet-1272	499	36	.	.	PROPN
admet-1272	499	37	sloane	sloane	PROPN
admet-1272	499	38	,	,	PUNCT
admet-1272	499	39	m.c	m.c	PROPN
admet-1272	499	40	.	.	PROPN
admet-1272	499	41	stevens	stevens	PROPN
admet-1272	499	42	.	.	PUNCT
admet-1272	499	43	scalable	scalable	ADJ
admet-1272	499	44	synthesis	synthesis	NOUN
admet-1272	499	45	of	of	ADP
admet-1272	499	46	bryostatin	bryostatin	PROPN
admet-1272	499	47	1	1	NUM
admet-1272	499	48	and	and	CCONJ
admet-1272	499	49	analogs	analog	NOUN
admet-1272	499	50	,	,	PUNCT
admet-1272	499	51	adjuvant	adjuvant	ADJ
admet-1272	499	52	leads	lead	VERB
admet-1272	499	53	against	against	ADP
admet-1272	499	54	latent	latent	PROPN
admet-1272	499	55	hiv	hiv	PROPN
admet-1272	499	56	.	.	PUNCT
admet-1272	500	1	science	science	NOUN
admet-1272	500	2	358	358	NUM
admet-1272	500	3	(	(	PUNCT
admet-1272	500	4	2017	2017	NUM
admet-1272	500	5	)	)	PUNCT
admet-1272	500	6	218	218	NUM
admet-1272	500	7	-	-	SYM
admet-1272	500	8	223	223	NUM
admet-1272	500	9	.	.	PUNCT
admet-1272	501	1	https://doi.org/10.1126/science.aan7969	https://doi.org/10.1126/science.aan7969	PROPN
admet-1272	501	2	.	.	PUNCT
admet-1272	502	1	©	©	NOUN
admet-1272	502	2	2022	2022	NUM
admet-1272	502	3	by	by	ADP
admet-1272	502	4	the	the	DET
admet-1272	502	5	authors	author	NOUN
admet-1272	502	6	;	;	PUNCT
admet-1272	502	7	licensee	licensee	PROPN
admet-1272	502	8	iapc	iapc	PROPN
admet-1272	502	9	,	,	PUNCT
admet-1272	502	10	zagreb	zagreb	PROPN
admet-1272	502	11	,	,	PUNCT
admet-1272	502	12	croatia	croatia	PROPN
admet-1272	502	13	.	.	PUNCT
admet-1272	503	1	this	this	DET
admet-1272	503	2	article	article	NOUN
admet-1272	503	3	is	be	AUX
admet-1272	503	4	an	an	DET
admet-1272	503	5	open	open	ADJ
admet-1272	503	6	-	-	PUNCT
admet-1272	503	7	access	access	NOUN
admet-1272	503	8	article	article	NOUN
admet-1272	503	9	distributed	distribute	VERB
admet-1272	503	10	under	under	ADP
admet-1272	503	11	the	the	DET
admet-1272	503	12	terms	term	NOUN
admet-1272	503	13	and	and	CCONJ
admet-1272	503	14	conditions	condition	NOUN
admet-1272	503	15	of	of	ADP
admet-1272	503	16	the	the	DET
admet-1272	503	17	creative	creative	ADJ
admet-1272	503	18	commons	common	NOUN
admet-1272	503	19	attribution	attribution	NOUN
admet-1272	503	20	license	license	NOUN
admet-1272	503	21	(	(	PUNCT
admet-1272	503	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1272	503	23	)	)	PUNCT
admet-1272	503	24	https://doi.org/10.3389/fchem.2021.687875	https://doi.org/10.3389/fchem.2021.687875	PROPN
admet-1272	503	25	https://doi.org/10.1016/j.medidd.2020.100078	https://doi.org/10.1016/j.medidd.2020.100078	PROPN
admet-1272	503	26	https://doi.org/10.1016/j.phrs.2020.105276	https://doi.org/10.1016/j.phrs.2020.105276	PROPN
admet-1272	503	27	https://doi.org/10.1002/med.21879	https://doi.org/10.1002/med.21879	PROPN
admet-1272	503	28	https://doi.org/10.1039/d0np00003e	https://doi.org/10.1039/d0np00003e	PROPN
admet-1272	503	29	https://doi.org/10.1126/science.aan7969	https://doi.org/10.1126/science.aan7969	PROPN
admet-1272	503	30	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN