id	sid	tid	token	lemma	pos
admet-1427	1	1	effect	effect	NOUN
admet-1427	1	2	of	of	ADP
admet-1427	1	3	divalent	divalent	NOUN
admet-1427	1	4	and	and	CCONJ
admet-1427	1	5	trivalent	trivalent	NOUN
admet-1427	1	6	metal	metal	NOUN
admet-1427	1	7	ions	ion	NOUN
admet-1427	1	8	on	on	ADP
admet-1427	1	9	artificial	artificial	ADJ
admet-1427	1	10	membrane	membrane	NOUN
admet-1427	1	11	permeation	permeation	NOUN
admet-1427	1	12	of	of	ADP
admet-1427	1	13	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	1	14	doi	doi	NOUN
admet-1427	1	15	:	:	PUNCT
admet-1427	1	16	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	NUM
admet-1427	1	17	289	289	NUM
admet-1427	1	18	admet	admet	NOUN
admet-1427	1	19	&	&	CCONJ
admet-1427	1	20	dmpk	dmpk	PROPN
admet-1427	1	21	10(4	10(4	NUM
admet-1427	1	22	)	)	PUNCT
admet-1427	1	23	(	(	PUNCT
admet-1427	1	24	2022	2022	NUM
admet-1427	1	25	)	)	PUNCT
admet-1427	1	26	289	289	NUM
admet-1427	1	27	-	-	SYM
admet-1427	1	28	297	297	NUM
admet-1427	1	29	;	;	PUNCT
admet-1427	1	30	doi	doi	NOUN
admet-1427	1	31	:	:	PUNCT
admet-1427	1	32	https://doi.org/10.5599/admet.1427	https://doi.org/10.5599/admet.1427	NOUN
admet-1427	1	33	open	open	ADJ
admet-1427	1	34	access	access	NOUN
admet-1427	1	35	:	:	PUNCT
admet-1427	1	36	issn	issn	PROPN
admet-1427	1	37	:	:	PUNCT
admet-1427	1	38	1848	1848	NUM
admet-1427	1	39	-	-	SYM
admet-1427	1	40	7718	7718	NUM
admet-1427	1	41	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1427	1	42	original	original	ADJ
admet-1427	1	43	scientific	scientific	ADJ
admet-1427	1	44	paper	paper	NOUN
admet-1427	1	45	effect	effect	NOUN
admet-1427	1	46	of	of	ADP
admet-1427	1	47	divalent	divalent	NOUN
admet-1427	1	48	and	and	CCONJ
admet-1427	1	49	trivalent	trivalent	NOUN
admet-1427	1	50	metal	metal	NOUN
admet-1427	1	51	ions	ion	NOUN
admet-1427	1	52	on	on	ADP
admet-1427	1	53	artificial	artificial	ADJ
admet-1427	1	54	membrane	membrane	NOUN
admet-1427	1	55	permeation	permeation	NOUN
admet-1427	1	56	of	of	ADP
admet-1427	1	57	fluoroquinolones1	fluoroquinolones1	PROPN
admet-1427	1	58	nanami	nanami	PROPN
admet-1427	1	59	nakatani	nakatani	PROPN
admet-1427	1	60	,	,	PUNCT
admet-1427	1	61	kiyohiko	kiyohiko	NOUN
admet-1427	1	62	sugano	sugano	NOUN
admet-1427	1	63	*	*	PUNCT
admet-1427	1	64	molecular	molecular	ADJ
admet-1427	1	65	pharmaceutics	pharmaceutic	NOUN
admet-1427	1	66	lab	lab	NOUN
admet-1427	1	67	.	.	PUNCT
admet-1427	1	68	,	,	PUNCT
admet-1427	1	69	college	college	NOUN
admet-1427	1	70	of	of	ADP
admet-1427	1	71	pharmaceutical	pharmaceutical	NOUN
admet-1427	1	72	sciences	science	NOUN
admet-1427	1	73	,	,	PUNCT
admet-1427	1	74	ritsumeikan	ritsumeikan	ADJ
admet-1427	1	75	university	university	NOUN
admet-1427	1	76	,	,	PUNCT
admet-1427	1	77	1	1	NUM
admet-1427	1	78	-	-	SYM
admet-1427	1	79	1	1	NUM
admet-1427	1	80	-	-	SYM
admet-1427	1	81	1	1	NUM
admet-1427	1	82	,	,	PUNCT
admet-1427	1	83	noji	noji	NOUN
admet-1427	1	84	-	-	PUNCT
admet-1427	1	85	higashi	higashi	PROPN
admet-1427	1	86	,	,	PUNCT
admet-1427	1	87	kusatsu	kusatsu	NOUN
admet-1427	1	88	,	,	PUNCT
admet-1427	1	89	shiga	shiga	NOUN
admet-1427	1	90	525	525	NUM
admet-1427	1	91	-	-	SYM
admet-1427	1	92	8577	8577	NUM
admet-1427	1	93	,	,	PUNCT
admet-1427	1	94	japan	japan	PROPN
admet-1427	1	95	*	*	PUNCT
admet-1427	1	96	corresponding	correspond	VERB
admet-1427	1	97	author	author	NOUN
admet-1427	1	98	:	:	PUNCT
admet-1427	1	99	e	e	NOUN
admet-1427	1	100	-	-	NOUN
admet-1427	1	101	mail	mail	NOUN
admet-1427	1	102	:	:	PUNCT
admet-1427	1	103	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-1427	1	104	;	;	PUNCT
admet-1427	1	105	tel	tel	PROPN
admet-1427	1	106	.	.	PROPN
admet-1427	1	107	:	:	PUNCT
admet-1427	2	1	+81	+81	PROPN
admet-1427	2	2	-	-	PUNCT
admet-1427	2	3	77	77	NUM
admet-1427	2	4	-	-	PUNCT
admet-1427	2	5	561	561	NUM
admet-1427	2	6	-	-	PUNCT
admet-1427	2	7	2773	2773	NUM
admet-1427	2	8	received	receive	VERB
admet-1427	2	9	:	:	PUNCT
admet-1427	2	10	june	june	PROPN
admet-1427	2	11	27	27	NUM
admet-1427	2	12	,	,	PUNCT
admet-1427	2	13	2022	2022	NUM
admet-1427	2	14	;	;	PUNCT
admet-1427	2	15	revised	revise	VERB
admet-1427	2	16	:	:	PUNCT
admet-1427	2	17	september	september	PROPN
admet-1427	2	18	02	02	NUM
admet-1427	2	19	,	,	PUNCT
admet-1427	2	20	2022	2022	NUM
admet-1427	2	21	;	;	PUNCT
admet-1427	2	22	published	publish	VERB
admet-1427	2	23	:	:	PUNCT
admet-1427	2	24	september	september	PROPN
admet-1427	2	25	07	07	NUM
admet-1427	2	26	,	,	PUNCT
admet-1427	2	27	2022	2022	NUM
admet-1427	2	28	abstract	abstract	NOUN
admet-1427	2	29	the	the	DET
admet-1427	2	30	purpose	purpose	NOUN
admet-1427	2	31	of	of	ADP
admet-1427	2	32	the	the	DET
admet-1427	2	33	present	present	ADJ
admet-1427	2	34	study	study	NOUN
admet-1427	2	35	was	be	AUX
admet-1427	2	36	to	to	PART
admet-1427	2	37	evaluate	evaluate	VERB
admet-1427	2	38	the	the	DET
admet-1427	2	39	predictability	predictability	NOUN
admet-1427	2	40	of	of	ADP
admet-1427	2	41	pampa	pampa	NOUN
admet-1427	2	42	for	for	ADP
admet-1427	2	43	the	the	DET
admet-1427	2	44	effect	effect	NOUN
admet-1427	2	45	of	of	ADP
admet-1427	2	46	metal	metal	NOUN
admet-1427	2	47	ions	ion	NOUN
admet-1427	2	48	on	on	ADP
admet-1427	2	49	the	the	DET
admet-1427	2	50	bioavailability	bioavailability	NOUN
admet-1427	2	51	of	of	ADP
admet-1427	2	52	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	2	53	(	(	PUNCT
admet-1427	2	54	fq	fq	PROPN
admet-1427	2	55	)	)	PUNCT
admet-1427	2	56	.	.	PUNCT
admet-1427	3	1	eleven	eleven	NUM
admet-1427	3	2	fqs	fqs	ADJ
admet-1427	3	3	and	and	CCONJ
admet-1427	3	4	seven	seven	NUM
admet-1427	3	5	metal	metal	NOUN
admet-1427	3	6	ions	ion	NOUN
admet-1427	3	7	were	be	AUX
admet-1427	3	8	employed	employ	VERB
admet-1427	3	9	in	in	ADP
admet-1427	3	10	this	this	DET
admet-1427	3	11	study	study	NOUN
admet-1427	3	12	.	.	PUNCT
admet-1427	4	1	the	the	DET
admet-1427	4	2	pampa	pampa	PROPN
admet-1427	4	3	membrane	membrane	NOUN
admet-1427	4	4	consisted	consist	VERB
admet-1427	4	5	of	of	ADP
admet-1427	4	6	a	a	DET
admet-1427	4	7	10	10	NUM
admet-1427	4	8	%	%	NOUN
admet-1427	4	9	soybean	soybean	NOUN
admet-1427	4	10	lecithin	lecithin	NOUN
admet-1427	4	11	(	(	PUNCT
admet-1427	4	12	sl	sl	NOUN
admet-1427	4	13	)	)	PUNCT
admet-1427	4	14	–	–	PUNCT
admet-1427	4	15	decane	decane	NOUN
admet-1427	4	16	solution	solution	NOUN
admet-1427	4	17	.	.	PUNCT
admet-1427	5	1	a	a	DET
admet-1427	5	2	drug	drug	NOUN
admet-1427	5	3	solution	solution	NOUN
admet-1427	5	4	in	in	ADP
admet-1427	5	5	mes	me	NOUN
admet-1427	5	6	buffer	buffer	NOUN
admet-1427	5	7	with	with	ADP
admet-1427	5	8	or	or	CCONJ
admet-1427	5	9	without	without	ADP
admet-1427	5	10	a	a	DET
admet-1427	5	11	metal	metal	NOUN
admet-1427	5	12	ion	ion	NOUN
admet-1427	5	13	(	(	PUNCT
admet-1427	5	14	added	add	VERB
admet-1427	5	15	as	as	ADP
admet-1427	5	16	a	a	DET
admet-1427	5	17	chloride	chloride	NOUN
admet-1427	5	18	salt	salt	NOUN
admet-1427	5	19	)	)	PUNCT
admet-1427	5	20	was	be	AUX
admet-1427	5	21	added	add	VERB
admet-1427	5	22	to	to	ADP
admet-1427	5	23	the	the	DET
admet-1427	5	24	donor	donor	NOUN
admet-1427	5	25	compartment	compartment	NOUN
admet-1427	5	26	.	.	PUNCT
admet-1427	6	1	in	in	ADP
admet-1427	6	2	the	the	DET
admet-1427	6	3	absence	absence	NOUN
admet-1427	6	4	of	of	ADP
admet-1427	6	5	metal	metal	NOUN
admet-1427	6	6	ions	ion	NOUN
admet-1427	6	7	,	,	PUNCT
admet-1427	6	8	fq	fq	PROPN
admet-1427	6	9	showed	show	VERB
admet-1427	6	10	relatively	relatively	ADV
admet-1427	6	11	high	high	ADJ
admet-1427	6	12	permeability	permeability	NOUN
admet-1427	6	13	(	(	PUNCT
admet-1427	6	14	>	>	X
admet-1427	6	15	5	5	NUM
admet-1427	6	16	×	×	NOUN
admet-1427	6	17	10	10	NUM
admet-1427	6	18	-	-	SYM
admet-1427	6	19	6	6	NUM
admet-1427	6	20	cm	cm	NOUN
admet-1427	6	21	/	/	SYM
admet-1427	6	22	sec	sec	PROPN
admet-1427	6	23	)	)	PUNCT
admet-1427	6	24	in	in	ADP
admet-1427	6	25	sl	sl	NOUN
admet-1427	6	26	-	-	PUNCT
admet-1427	6	27	pampa	pampa	NOUN
admet-1427	6	28	despite	despite	SCONJ
admet-1427	6	29	their	their	PRON
admet-1427	6	30	hydrophilic	hydrophilic	ADJ
admet-1427	6	31	and	and	CCONJ
admet-1427	6	32	zwitterionic	zwitterionic	ADJ
admet-1427	6	33	properties	property	NOUN
admet-1427	6	34	.	.	PUNCT
admet-1427	7	1	as	as	SCONJ
admet-1427	7	2	the	the	DET
admet-1427	7	3	pampa	pampa	NOUN
admet-1427	7	4	permeability	permeability	NOUN
admet-1427	7	5	ratio	ratio	NOUN
admet-1427	7	6	with	with	ADP
admet-1427	7	7	/	/	SYM
admet-1427	7	8	without	without	ADP
admet-1427	7	9	metal	metal	NOUN
admet-1427	7	10	ions	ion	NOUN
admet-1427	7	11	became	become	VERB
admet-1427	7	12	smaller	small	ADJ
admet-1427	7	13	,	,	PUNCT
admet-1427	7	14	the	the	DET
admet-1427	7	15	urinary	urinary	ADJ
admet-1427	7	16	excretion	excretion	NOUN
admet-1427	7	17	and	and	CCONJ
admet-1427	7	18	auc	auc	NOUN
admet-1427	7	19	ratios	ratio	NOUN
admet-1427	7	20	tended	tend	VERB
admet-1427	7	21	to	to	PART
admet-1427	7	22	be	be	AUX
admet-1427	7	23	smaller	small	ADJ
admet-1427	7	24	,	,	PUNCT
admet-1427	7	25	suggesting	suggest	VERB
admet-1427	7	26	that	that	SCONJ
admet-1427	7	27	sl	sl	NOUN
admet-1427	7	28	-	-	PUNCT
admet-1427	7	29	pampa	pampa	NOUN
admet-1427	7	30	is	be	AUX
admet-1427	7	31	a	a	DET
admet-1427	7	32	suitable	suitable	ADJ
admet-1427	7	33	in	in	ADP
admet-1427	7	34	vitro	vitro	X
admet-1427	7	35	model	model	NOUN
admet-1427	7	36	to	to	PART
admet-1427	7	37	evaluate	evaluate	VERB
admet-1427	7	38	the	the	DET
admet-1427	7	39	potential	potential	ADJ
admet-1427	7	40	effect	effect	NOUN
admet-1427	7	41	of	of	ADP
admet-1427	7	42	metal	metal	NOUN
admet-1427	7	43	ions	ion	NOUN
admet-1427	7	44	on	on	ADP
admet-1427	7	45	the	the	DET
admet-1427	7	46	bioavailability	bioavailability	NOUN
admet-1427	7	47	of	of	ADP
admet-1427	7	48	fq	fq	PROPN
admet-1427	7	49	.	.	PUNCT
admet-1427	8	1	however	however	ADV
admet-1427	8	2	,	,	PUNCT
admet-1427	8	3	the	the	DET
admet-1427	8	4	reduction	reduction	NOUN
admet-1427	8	5	in	in	ADP
admet-1427	8	6	auc	auc	NOUN
admet-1427	8	7	and	and	CCONJ
admet-1427	8	8	urinary	urinary	ADJ
admet-1427	8	9	excretion	excretion	NOUN
admet-1427	8	10	was	be	AUX
admet-1427	8	11	overestimated	overestimate	VERB
admet-1427	8	12	for	for	ADP
admet-1427	8	13	low	low	ADJ
admet-1427	8	14	solubility	solubility	NOUN
admet-1427	8	15	metal	metal	NOUN
admet-1427	8	16	ion	ion	NOUN
admet-1427	8	17	formulations	formulation	NOUN
admet-1427	8	18	(	(	PUNCT
admet-1427	8	19	dried	dry	VERB
admet-1427	8	20	aluminum	aluminum	NOUN
admet-1427	8	21	hydroxide	hydroxide	NOUN
admet-1427	8	22	gel	gel	NOUN
admet-1427	8	23	and	and	CCONJ
admet-1427	8	24	la2(co3)3・8h2o	la2(co3)3・8h2o	PROPN
admet-1427	8	25	)	)	PUNCT
admet-1427	8	26	.	.	PUNCT
admet-1427	9	1	in	in	ADP
admet-1427	9	2	such	such	ADJ
admet-1427	9	3	cases	case	NOUN
admet-1427	9	4	,	,	PUNCT
admet-1427	9	5	the	the	DET
admet-1427	9	6	dissolution	dissolution	NOUN
admet-1427	9	7	of	of	ADP
admet-1427	9	8	the	the	DET
admet-1427	9	9	metal	metal	NOUN
admet-1427	9	10	ion	ion	NOUN
admet-1427	9	11	formulations	formulation	NOUN
admet-1427	9	12	and	and	CCONJ
admet-1427	9	13	the	the	DET
admet-1427	9	14	permeation	permeation	NOUN
admet-1427	9	15	of	of	ADP
admet-1427	9	16	fqs	fqs	NOUN
admet-1427	9	17	should	should	AUX
admet-1427	9	18	be	be	AUX
admet-1427	9	19	simultaneously	simultaneously	ADV
admet-1427	9	20	evaluated	evaluate	VERB
admet-1427	9	21	.	.	PUNCT
admet-1427	10	1	©	©	NOUN
admet-1427	10	2	2022	2022	NUM
admet-1427	10	3	by	by	ADP
admet-1427	10	4	the	the	DET
admet-1427	10	5	authors	author	NOUN
admet-1427	10	6	.	.	PUNCT
admet-1427	11	1	this	this	DET
admet-1427	11	2	article	article	NOUN
admet-1427	11	3	is	be	AUX
admet-1427	11	4	an	an	DET
admet-1427	11	5	open	open	ADJ
admet-1427	11	6	-	-	PUNCT
admet-1427	11	7	access	access	NOUN
admet-1427	11	8	article	article	NOUN
admet-1427	11	9	distributed	distribute	VERB
admet-1427	11	10	under	under	ADP
admet-1427	11	11	the	the	DET
admet-1427	11	12	terms	term	NOUN
admet-1427	11	13	and	and	CCONJ
admet-1427	11	14	conditions	condition	NOUN
admet-1427	11	15	of	of	ADP
admet-1427	11	16	the	the	DET
admet-1427	11	17	creative	creative	ADJ
admet-1427	11	18	commons	common	NOUN
admet-1427	11	19	attribution	attribution	NOUN
admet-1427	11	20	license	license	NOUN
admet-1427	11	21	(	(	PUNCT
admet-1427	11	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1427	11	23	)	)	PUNCT
admet-1427	11	24	.	.	PUNCT
admet-1427	12	1	keywords	keyword	VERB
admet-1427	12	2	artificial	artificial	ADJ
admet-1427	12	3	membrane	membrane	NOUN
admet-1427	12	4	;	;	PUNCT
admet-1427	12	5	permeability	permeability	NOUN
admet-1427	12	6	;	;	PUNCT
admet-1427	12	7	phospholipid	phospholipid	NOUN
admet-1427	12	8	;	;	PUNCT
admet-1427	12	9	fluoroquinolone	fluoroquinolone	NOUN
admet-1427	12	10	;	;	PUNCT
admet-1427	12	11	metal	metal	NOUN
admet-1427	12	12	;	;	PUNCT
admet-1427	12	13	cation	cation	NOUN
admet-1427	12	14	introduction	introduction	NOUN
admet-1427	12	15	multivalent	multivalent	NOUN
admet-1427	12	16	metal	metal	NOUN
admet-1427	12	17	cations	cation	NOUN
admet-1427	12	18	are	be	AUX
admet-1427	12	19	present	present	ADJ
admet-1427	12	20	in	in	ADP
admet-1427	12	21	many	many	ADJ
admet-1427	12	22	pharmaceutical	pharmaceutical	ADJ
admet-1427	12	23	and	and	CCONJ
admet-1427	12	24	nutraceutical	nutraceutical	ADJ
admet-1427	12	25	products	product	NOUN
admet-1427	12	26	,	,	PUNCT
admet-1427	12	27	such	such	ADJ
admet-1427	12	28	as	as	ADP
admet-1427	12	29	antacids	antacid	NOUN
admet-1427	12	30	,	,	PUNCT
admet-1427	12	31	phosphate	phosphate	ADJ
admet-1427	12	32	binders	binder	NOUN
admet-1427	12	33	,	,	PUNCT
admet-1427	12	34	and	and	CCONJ
admet-1427	12	35	iron	iron	NOUN
admet-1427	12	36	supplements	supplement	NOUN
admet-1427	12	37	.	.	PUNCT
admet-1427	13	1	the	the	DET
admet-1427	13	2	concomitant	concomitant	PROPN
admet-1427	13	3	administration	administration	NOUN
admet-1427	13	4	of	of	ADP
admet-1427	13	5	these	these	DET
admet-1427	13	6	multivalent	multivalent	ADJ
admet-1427	13	7	metal	metal	NOUN
admet-1427	13	8	salt	salt	NOUN
admet-1427	13	9	formulations	formulation	NOUN
admet-1427	13	10	can	can	AUX
admet-1427	13	11	reduce	reduce	VERB
admet-1427	13	12	the	the	DET
admet-1427	13	13	bioavailability	bioavailability	NOUN
admet-1427	13	14	of	of	ADP
admet-1427	13	15	various	various	ADJ
admet-1427	13	16	drugs	drug	NOUN
admet-1427	13	17	,	,	PUNCT
admet-1427	13	18	such	such	ADJ
admet-1427	13	19	as	as	ADP
admet-1427	13	20	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	13	21	(	(	PUNCT
admet-1427	13	22	fq	fq	NOUN
admet-1427	13	23	)	)	PUNCT
admet-1427	14	1	[	[	X
admet-1427	14	2	1,2	1,2	NUM
admet-1427	14	3	]	]	PUNCT
admet-1427	14	4	,	,	PUNCT
admet-1427	14	5	tetracyclines	tetracycline	NOUN
admet-1427	15	1	[	[	X
admet-1427	15	2	3	3	NUM
admet-1427	15	3	]	]	PUNCT
admet-1427	15	4	,	,	PUNCT
admet-1427	15	5	and	and	CCONJ
admet-1427	15	6	hiv	hiv	PROPN
admet-1427	15	7	-	-	PUNCT
admet-1427	15	8	integrase	integrase	NOUN
admet-1427	15	9	inhibitors	inhibitor	NOUN
admet-1427	15	10	[	[	X
admet-1427	15	11	4	4	NUM
admet-1427	15	12	]	]	PUNCT
admet-1427	15	13	.	.	PUNCT
admet-1427	16	1	in	in	ADP
admet-1427	16	2	an	an	DET
admet-1427	16	3	acidic	acidic	ADJ
admet-1427	16	4	environment	environment	NOUN
admet-1427	16	5	of	of	ADP
admet-1427	16	6	the	the	DET
admet-1427	16	7	stomach	stomach	NOUN
admet-1427	16	8	,	,	PUNCT
admet-1427	16	9	a	a	DET
admet-1427	16	10	metal	metal	NOUN
admet-1427	16	11	cation	cation	NOUN
admet-1427	16	12	exists	exist	VERB
admet-1427	16	13	as	as	ADP
admet-1427	16	14	a	a	DET
admet-1427	16	15	dissociated	dissociate	VERB
admet-1427	16	16	ion	ion	NOUN
admet-1427	16	17	.	.	PUNCT
admet-1427	17	1	however	however	ADV
admet-1427	17	2	,	,	PUNCT
admet-1427	17	3	it	it	PRON
admet-1427	17	4	could	could	AUX
admet-1427	17	5	form	form	VERB
admet-1427	17	6	a	a	DET
admet-1427	17	7	complex	complex	NOUN
admet-1427	17	8	with	with	ADP
admet-1427	17	9	a	a	DET
admet-1427	17	10	drug	drug	NOUN
admet-1427	17	11	molecule	molecule	NOUN
admet-1427	17	12	in	in	ADP
admet-1427	17	13	a	a	DET
admet-1427	17	14	neutral	neutral	ADJ
admet-1427	17	15	ph	ph	ADJ
admet-1427	17	16	environment	environment	NOUN
admet-1427	17	17	of	of	ADP
admet-1427	17	18	the	the	DET
admet-1427	17	19	small	small	ADJ
admet-1427	17	20	intestine	intestine	NOUN
admet-1427	17	21	.	.	PUNCT
admet-1427	18	1	it	it	PRON
admet-1427	18	2	is	be	AUX
admet-1427	18	3	well	well	ADV
admet-1427	18	4	known	know	VERB
admet-1427	18	5	that	that	SCONJ
admet-1427	18	6	multivalent	multivalent	NOUN
admet-1427	18	7	metal	metal	NOUN
admet-1427	18	8	cations	cation	NOUN
admet-1427	18	9	reduce	reduce	VERB
admet-1427	18	10	the	the	DET
admet-1427	18	11	intestinal	intestinal	ADJ
admet-1427	18	12	membrane	membrane	NOUN
admet-1427	18	13	permeation	permeation	NOUN
admet-1427	18	14	of	of	ADP
admet-1427	18	15	some	some	DET
admet-1427	18	16	fqs	fqs	NOUN
admet-1427	18	17	by	by	ADP
admet-1427	18	18	chelate	chelate	NOUN
admet-1427	18	19	formation	formation	NOUN
admet-1427	19	1	[	[	X
admet-1427	19	2	2	2	NUM
admet-1427	19	3	]	]	PUNCT
admet-1427	19	4	.	.	PUNCT
admet-1427	20	1	to	to	PART
admet-1427	20	2	avoid	avoid	VERB
admet-1427	20	3	fq	fq	PROPN
admet-1427	20	4	multivalent	multivalent	NOUN
admet-1427	20	5	cation	cation	NOUN
admet-1427	20	6	interactions	interaction	NOUN
admet-1427	20	7	in	in	ADP
admet-1427	20	8	the	the	DET
admet-1427	20	9	gastrointestinal	gastrointestinal	ADJ
admet-1427	20	10	tract	tract	NOUN
admet-1427	20	11	,	,	PUNCT
admet-1427	20	12	it	it	PRON
admet-1427	20	13	is	be	AUX
admet-1427	20	14	recommended	recommend	VERB
admet-1427	20	15	to	to	PART
admet-1427	20	16	separate	separate	VERB
admet-1427	20	17	the	the	DET
admet-1427	20	18	drug	drug	NOUN
admet-1427	20	19	administration	administration	PROPN
admet-1427	20	20	times	time	NOUN
admet-1427	21	1	[	[	X
admet-1427	21	2	5	5	NUM
admet-1427	21	3	]	]	PUNCT
admet-1427	21	4	.	.	PUNCT
admet-1427	22	1	however	however	ADV
admet-1427	22	2	,	,	PUNCT
admet-1427	22	3	this	this	PRON
admet-1427	22	4	may	may	AUX
admet-1427	22	5	decrease	decrease	VERB
admet-1427	22	6	patient	patient	ADJ
admet-1427	22	7	medication	medication	NOUN
admet-1427	22	8	adherence	adherence	NOUN
admet-1427	22	9	.	.	PUNCT
admet-1427	23	1	currently	currently	ADV
admet-1427	23	2	,	,	PUNCT
admet-1427	23	3	more	more	ADJ
admet-1427	23	4	than	than	ADP
admet-1427	23	5	a	a	DET
admet-1427	23	6	dozen	dozen	NOUN
admet-1427	23	7	fqs	fqs	NOUN
admet-1427	23	8	and	and	CCONJ
admet-1427	23	9	several	several	ADJ
admet-1427	23	10	multivalent	multivalent	NOUN
admet-1427	23	11	metal	metal	NOUN
admet-1427	23	12	1	1	NUM
admet-1427	23	13	this	this	DET
admet-1427	23	14	paper	paper	NOUN
admet-1427	23	15	is	be	AUX
admet-1427	23	16	dedicated	dedicate	VERB
admet-1427	23	17	to	to	ADP
admet-1427	23	18	the	the	DET
admet-1427	23	19	memory	memory	NOUN
admet-1427	23	20	of	of	ADP
admet-1427	23	21	dr	dr	PROPN
admet-1427	23	22	.	.	PROPN
admet-1427	23	23	konstantin	konstantin	PROPN
admet-1427	23	24	tsinman	tsinman	PROPN
admet-1427	23	25	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	X
admet-1427	23	26	https://doi.org/10.5599/admet.1427	https://doi.org/10.5599/admet.1427	NOUN
admet-1427	23	27	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1427	23	28	mailto:suganok@fc.ritsumei.ac.jp	mailto:suganok@fc.ritsumei.ac.jp	PROPN
admet-1427	23	29	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1427	23	30	nakatani	nakatani	PROPN
admet-1427	23	31	and	and	CCONJ
admet-1427	23	32	sugano	sugano	VERB
admet-1427	23	33	admet	admet	PROPN
admet-1427	23	34	&	&	CCONJ
admet-1427	23	35	dmpk	dmpk	PROPN
admet-1427	23	36	10(4	10(4	NUM
admet-1427	23	37	)	)	PUNCT
admet-1427	23	38	(	(	PUNCT
admet-1427	23	39	2022	2022	NUM
admet-1427	23	40	)	)	PUNCT
admet-1427	23	41	289	289	NUM
admet-1427	23	42	-	-	SYM
admet-1427	23	43	297	297	NUM
admet-1427	23	44	290	290	NUM
admet-1427	23	45	salt	salt	NOUN
admet-1427	23	46	formulations	formulation	NOUN
admet-1427	23	47	are	be	AUX
admet-1427	23	48	prescribed	prescribe	VERB
admet-1427	23	49	in	in	ADP
admet-1427	23	50	clinical	clinical	ADJ
admet-1427	23	51	practice	practice	NOUN
admet-1427	23	52	.	.	PUNCT
admet-1427	24	1	however	however	ADV
admet-1427	24	2	,	,	PUNCT
admet-1427	24	3	it	it	PRON
admet-1427	24	4	is	be	AUX
admet-1427	24	5	practically	practically	ADV
admet-1427	24	6	impossible	impossible	ADJ
admet-1427	24	7	to	to	PART
admet-1427	24	8	examine	examine	VERB
admet-1427	24	9	the	the	DET
admet-1427	24	10	effect	effect	NOUN
admet-1427	24	11	of	of	ADP
admet-1427	24	12	metal	metal	NOUN
admet-1427	24	13	salt	salt	NOUN
admet-1427	24	14	formulations	formulation	NOUN
admet-1427	24	15	on	on	ADP
admet-1427	24	16	the	the	DET
admet-1427	24	17	bioavailability	bioavailability	NOUN
admet-1427	24	18	of	of	ADP
admet-1427	24	19	fqs	fqs	NOUN
admet-1427	24	20	for	for	ADP
admet-1427	24	21	all	all	DET
admet-1427	24	22	combinations	combination	NOUN
admet-1427	24	23	by	by	ADP
admet-1427	24	24	clinical	clinical	ADJ
admet-1427	24	25	studies	study	NOUN
admet-1427	24	26	.	.	PUNCT
admet-1427	25	1	the	the	DET
admet-1427	25	2	parallel	parallel	ADJ
admet-1427	25	3	artificial	artificial	ADJ
admet-1427	25	4	membrane	membrane	NOUN
admet-1427	25	5	permeation	permeation	NOUN
admet-1427	25	6	assay	assay	NOUN
admet-1427	25	7	(	(	PUNCT
admet-1427	25	8	pampa	pampa	PROPN
admet-1427	25	9	)	)	PUNCT
admet-1427	25	10	has	have	AUX
admet-1427	25	11	been	be	AUX
admet-1427	25	12	widely	widely	ADV
admet-1427	25	13	used	use	VERB
admet-1427	25	14	to	to	PART
admet-1427	25	15	assess	assess	VERB
admet-1427	25	16	the	the	DET
admet-1427	25	17	passive	passive	ADJ
admet-1427	25	18	membrane	membrane	NOUN
admet-1427	25	19	permeation	permeation	NOUN
admet-1427	25	20	of	of	ADP
admet-1427	25	21	drugs	drug	NOUN
admet-1427	25	22	[	[	X
admet-1427	25	23	6–9	6–9	NOUN
admet-1427	25	24	]	]	PUNCT
admet-1427	25	25	.	.	PUNCT
admet-1427	26	1	recently	recently	ADV
admet-1427	26	2	,	,	PUNCT
admet-1427	26	3	we	we	PRON
admet-1427	26	4	reported	report	VERB
admet-1427	26	5	that	that	SCONJ
admet-1427	26	6	the	the	DET
admet-1427	26	7	membrane	membrane	NOUN
admet-1427	26	8	permeation	permeation	NOUN
admet-1427	26	9	of	of	ADP
admet-1427	26	10	tetracyclines	tetracycline	NOUN
admet-1427	26	11	and	and	CCONJ
admet-1427	26	12	the	the	DET
admet-1427	26	13	effect	effect	NOUN
admet-1427	26	14	of	of	ADP
admet-1427	26	15	metal	metal	NOUN
admet-1427	26	16	ions	ion	NOUN
admet-1427	26	17	can	can	AUX
admet-1427	26	18	be	be	AUX
admet-1427	26	19	evaluated	evaluate	VERB
admet-1427	26	20	using	use	VERB
admet-1427	26	21	a	a	DET
admet-1427	26	22	phospholipid	phospholipid	NOUN
admet-1427	26	23	-	-	PUNCT
admet-1427	26	24	based	base	VERB
admet-1427	26	25	pampa	pampa	NOUN
admet-1427	26	26	[	[	X
admet-1427	26	27	10,11	10,11	NOUN
admet-1427	26	28	]	]	X
admet-1427	26	29	.	.	PUNCT
admet-1427	27	1	however	however	ADV
admet-1427	27	2	,	,	PUNCT
admet-1427	27	3	it	it	PRON
admet-1427	27	4	has	have	AUX
admet-1427	27	5	been	be	AUX
admet-1427	27	6	unknown	unknown	ADJ
admet-1427	27	7	whether	whether	SCONJ
admet-1427	27	8	pampa	pampa	NOUN
admet-1427	27	9	can	can	AUX
admet-1427	27	10	predict	predict	VERB
admet-1427	27	11	the	the	DET
admet-1427	27	12	effect	effect	NOUN
admet-1427	27	13	of	of	ADP
admet-1427	27	14	metal	metal	NOUN
admet-1427	27	15	salt	salt	NOUN
admet-1427	27	16	formulations	formulation	NOUN
admet-1427	27	17	on	on	ADP
admet-1427	27	18	the	the	DET
admet-1427	27	19	bioavailability	bioavailability	NOUN
admet-1427	27	20	of	of	ADP
admet-1427	27	21	fqs	fqs	NOUN
admet-1427	27	22	.	.	PUNCT
admet-1427	28	1	the	the	DET
admet-1427	28	2	purpose	purpose	NOUN
admet-1427	28	3	of	of	ADP
admet-1427	28	4	the	the	DET
admet-1427	28	5	present	present	ADJ
admet-1427	28	6	study	study	NOUN
admet-1427	28	7	was	be	AUX
admet-1427	28	8	to	to	PART
admet-1427	28	9	evaluate	evaluate	VERB
admet-1427	28	10	the	the	DET
admet-1427	28	11	predictability	predictability	NOUN
admet-1427	28	12	of	of	ADP
admet-1427	28	13	pampa	pampa	NOUN
admet-1427	28	14	for	for	ADP
admet-1427	28	15	the	the	DET
admet-1427	28	16	effect	effect	NOUN
admet-1427	28	17	of	of	ADP
admet-1427	28	18	metal	metal	NOUN
admet-1427	28	19	ions	ion	NOUN
admet-1427	28	20	on	on	ADP
admet-1427	28	21	the	the	DET
admet-1427	28	22	bioavailability	bioavailability	NOUN
admet-1427	28	23	of	of	ADP
admet-1427	28	24	fqs	fqs	NOUN
admet-1427	28	25	.	.	PUNCT
admet-1427	29	1	eleven	eleven	NUM
admet-1427	29	2	fqs	fqs	ADJ
admet-1427	29	3	and	and	CCONJ
admet-1427	29	4	seven	seven	NUM
admet-1427	29	5	metal	metal	NOUN
admet-1427	29	6	ions	ion	NOUN
admet-1427	29	7	are	be	AUX
admet-1427	29	8	employed	employ	VERB
admet-1427	29	9	in	in	ADP
admet-1427	29	10	this	this	DET
admet-1427	29	11	study	study	NOUN
admet-1427	29	12	(	(	PUNCT
admet-1427	29	13	figure	figure	NOUN
admet-1427	29	14	1	1	NUM
admet-1427	29	15	,	,	PUNCT
admet-1427	29	16	table	table	NOUN
admet-1427	29	17	1	1	NUM
admet-1427	29	18	)	)	PUNCT
admet-1427	29	19	.	.	PUNCT
admet-1427	30	1	n	n	CCONJ
admet-1427	31	1	o	o	PROPN
admet-1427	31	2	n	n	CCONJ
admet-1427	31	3	nh	nh	NOUN
admet-1427	32	1	f	f	X
admet-1427	32	2	o	o	INTJ
admet-1427	33	1	oh	oh	INTJ
admet-1427	33	2	ch3	ch3	PROPN
admet-1427	33	3	o	o	NOUN
admet-1427	33	4	n	n	CCONJ
admet-1427	33	5	o	o	PROPN
admet-1427	33	6	n	n	CCONJ
admet-1427	33	7	n	n	PROPN
admet-1427	33	8	ch3	ch3	PROPN
admet-1427	34	1	f	f	X
admet-1427	34	2	o	o	INTJ
admet-1427	34	3	oh	oh	INTJ
admet-1427	34	4	ciprofloxacin	ciprofloxacin	NOUN
admet-1427	34	5	(	(	PUNCT
admet-1427	34	6	cpfx	cpfx	NOUN
admet-1427	34	7	)	)	PUNCT
admet-1427	34	8	ofloxacin	ofloxacin	NOUN
admet-1427	34	9	(	(	PUNCT
admet-1427	34	10	oflx	oflx	ADJ
admet-1427	34	11	)	)	PUNCT
admet-1427	34	12	ch3	ch3	PROPN
admet-1427	34	13	n	n	CCONJ
admet-1427	34	14	o	o	PROPN
admet-1427	34	15	n	n	CCONJ
admet-1427	34	16	nh	nh	NOUN
admet-1427	34	17	f	f	X
admet-1427	35	1	o	o	INTJ
admet-1427	36	1	oh	oh	INTJ
admet-1427	36	2	norfloxacin	norfloxacin	INTJ
admet-1427	36	3	(	(	PUNCT
admet-1427	36	4	nflx	nflx	PROPN
admet-1427	36	5	)	)	PUNCT
admet-1427	36	6	ch3	ch3	PROPN
admet-1427	36	7	n	n	CCONJ
admet-1427	36	8	o	o	PROPN
admet-1427	36	9	n	n	CCONJ
admet-1427	36	10	n	n	PROPN
admet-1427	36	11	nh	nh	NOUN
admet-1427	37	1	f	f	X
admet-1427	37	2	o	o	INTJ
admet-1427	38	1	oh	oh	INTJ
admet-1427	38	2	enoxacin	enoxacin	INTJ
admet-1427	38	3	(	(	PUNCT
admet-1427	38	4	enx	enx	NOUN
admet-1427	38	5	)	)	PUNCT
admet-1427	38	6	ch3	ch3	PROPN
admet-1427	38	7	n	n	CCONJ
admet-1427	38	8	n	n	PROPN
admet-1427	38	9	f	f	NOUN
admet-1427	38	10	n	n	ADV
admet-1427	39	1	oo	oo	INTJ
admet-1427	40	1	oh	oh	INTJ
admet-1427	40	2	f	f	NOUN
admet-1427	40	3	f	f	PROPN
admet-1427	40	4	fleroxacin	fleroxacin	PROPN
admet-1427	40	5	(	(	PUNCT
admet-1427	40	6	flrx	flrx	PROPN
admet-1427	40	7	)	)	PUNCT
admet-1427	40	8	ch3	ch3	PROPN
admet-1427	40	9	n	n	ADP
admet-1427	40	10	nho	nho	NOUN
admet-1427	40	11	ch3	ch3	PROPN
admet-1427	40	12	n	n	CCONJ
admet-1427	41	1	oo	oo	INTJ
admet-1427	42	1	oh	oh	INTJ
admet-1427	42	2	f	f	PROPN
admet-1427	42	3	gatifloxacin	gatifloxacin	PROPN
admet-1427	42	4	(	(	PUNCT
admet-1427	42	5	gflx	gflx	PROPN
admet-1427	42	6	)	)	PUNCT
admet-1427	42	7	ch3	ch3	PROPN
admet-1427	42	8	o	o	PROPN
admet-1427	42	9	n	n	CCONJ
admet-1427	42	10	nh	nh	PROPN
admet-1427	42	11	f	f	X
admet-1427	42	12	o	o	NOUN
admet-1427	42	13	n	n	CCONJ
admet-1427	42	14	o	o	NOUN
admet-1427	43	1	oh	oh	INTJ
admet-1427	43	2	h	h	NOUN
admet-1427	44	1	h	h	NOUN
admet-1427	44	2	moxifloxacin	moxifloxacin	NOUN
admet-1427	44	3	(	(	PUNCT
admet-1427	44	4	mflx	mflx	PROPN
admet-1427	44	5	)	)	PUNCT
admet-1427	44	6	ch3	ch3	PROPN
admet-1427	44	7	n	n	CCONJ
admet-1427	44	8	o	o	NOUN
admet-1427	44	9	s	s	X
admet-1427	45	1	o	o	NOUN
admet-1427	46	1	oh	oh	INTJ
admet-1427	46	2	f	f	PROPN
admet-1427	46	3	n	n	CCONJ
admet-1427	46	4	n	n	ADV
admet-1427	46	5	o	o	NOUN
admet-1427	46	6	o	o	X
admet-1427	46	7	o	o	X
admet-1427	46	8	ch3prulifloxacin	ch3prulifloxacin	PUNCT
admet-1427	46	9	(	(	PUNCT
admet-1427	46	10	pufx	pufx	PROPN
admet-1427	46	11	)	)	PUNCT
admet-1427	46	12	ch3	ch3	PROPN
admet-1427	46	13	n	n	PROPN
admet-1427	46	14	nh	nh	PROPN
admet-1427	46	15	ch3	ch3	PROPN
admet-1427	46	16	f	f	PROPN
admet-1427	47	1	n	n	CCONJ
admet-1427	48	1	oo	oo	INTJ
admet-1427	49	1	oh	oh	INTJ
admet-1427	49	2	nh2	nh2	PROPN
admet-1427	49	3	f	f	PROPN
admet-1427	49	4	sparfloxacin	sparfloxacin	PROPN
admet-1427	49	5	(	(	PUNCT
admet-1427	49	6	spfx	spfx	PROPN
admet-1427	49	7	)	)	PUNCT
admet-1427	49	8	n	n	NUM
admet-1427	50	1	nh2	nh2	PROPN
admet-1427	50	2	o	o	NOUN
admet-1427	50	3	n	n	CCONJ
admet-1427	50	4	n	n	NOUN
admet-1427	50	5	f	f	NOUN
admet-1427	51	1	f	f	X
admet-1427	52	1	o	o	INTJ
admet-1427	53	1	oh	oh	INTJ
admet-1427	53	2	f	f	NOUN
admet-1427	53	3	tosufloxacin	tosufloxacin	INTJ
admet-1427	53	4	(	(	PUNCT
admet-1427	53	5	tflx	tflx	PROPN
admet-1427	53	6	)	)	PUNCT
admet-1427	53	7	ch3	ch3	PROPN
admet-1427	53	8	o	o	PROPN
admet-1427	53	9	n	n	CCONJ
admet-1427	53	10	o	o	PROPN
admet-1427	53	11	n	n	CCONJ
admet-1427	53	12	n	n	PROPN
admet-1427	53	13	ch3	ch3	PROPN
admet-1427	54	1	f	f	PROPN
admet-1427	54	2	o	o	INTJ
admet-1427	54	3	oh	oh	INTJ
admet-1427	54	4	levofloxacin	levofloxacin	PROPN
admet-1427	54	5	(	(	PUNCT
admet-1427	54	6	lvfx	lvfx	NOUN
admet-1427	54	7	)	)	PUNCT
admet-1427	54	8	figure	figure	NOUN
admet-1427	54	9	1	1	NUM
admet-1427	54	10	.	.	PUNCT
admet-1427	55	1	chemical	chemical	NOUN
admet-1427	55	2	structures	structure	NOUN
admet-1427	55	3	of	of	ADP
admet-1427	55	4	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	55	5	used	use	VERB
admet-1427	55	6	in	in	ADP
admet-1427	55	7	this	this	DET
admet-1427	55	8	study	study	NOUN
admet-1427	55	9	experimental	experimental	ADJ
admet-1427	55	10	materials	material	NOUN
admet-1427	55	11	norfloxacin	norfloxacin	ADV
admet-1427	55	12	(	(	PUNCT
admet-1427	55	13	nflx	nflx	PROPN
admet-1427	55	14	)	)	PUNCT
admet-1427	55	15	,	,	PUNCT
admet-1427	55	16	ofloxacin	ofloxacin	NOUN
admet-1427	55	17	(	(	PUNCT
admet-1427	55	18	oflx	oflx	ADJ
admet-1427	55	19	)	)	PUNCT
admet-1427	55	20	,	,	PUNCT
admet-1427	55	21	tosufloxacin	tosufloxacin	PRON
admet-1427	55	22	tosylate	tosylate	VERB
admet-1427	55	23	monohydrate	monohydrate	PROPN
admet-1427	55	24	(	(	PUNCT
admet-1427	55	25	tflx	tflx	PROPN
admet-1427	55	26	)	)	PUNCT
admet-1427	55	27	,	,	PUNCT
admet-1427	55	28	calcium	calcium	NOUN
admet-1427	55	29	dichloride	dichloride	NOUN
admet-1427	55	30	,	,	PUNCT
admet-1427	55	31	magnesium	magnesium	NOUN
admet-1427	55	32	dichloride	dichloride	NOUN
admet-1427	55	33	,	,	PUNCT
admet-1427	55	34	iron(ii	iron(ii	ADJ
admet-1427	55	35	)	)	PUNCT
admet-1427	55	36	dichloride	dichloride	NOUN
admet-1427	55	37	tetrahydrate	tetrahydrate	NOUN
admet-1427	55	38	,	,	PUNCT
admet-1427	55	39	iron(iii	iron(iii	ADJ
admet-1427	55	40	)	)	PUNCT
admet-1427	55	41	chloride	chloride	NOUN
admet-1427	55	42	hexahydrate	hexahydrate	NOUN
admet-1427	55	43	,	,	PUNCT
admet-1427	55	44	aluminum(iii	aluminum(iii	ADJ
admet-1427	55	45	)	)	PUNCT
admet-1427	55	46	chloride	chloride	NOUN
admet-1427	55	47	hexahydrate	hexahydrate	NOUN
admet-1427	55	48	,	,	PUNCT
admet-1427	55	49	zinc	zinc	NOUN
admet-1427	55	50	chloride	chloride	NOUN
admet-1427	55	51	,	,	PUNCT
admet-1427	55	52	lanthanum	lanthanum	ADJ
admet-1427	55	53	chloride	chloride	NOUN
admet-1427	55	54	heptahydrate	heptahydrate	NOUN
admet-1427	55	55	,	,	PUNCT
admet-1427	55	56	1	1	NUM
admet-1427	55	57	-	-	PUNCT
admet-1427	55	58	octanol	octanol	NOUN
admet-1427	55	59	,	,	PUNCT
admet-1427	55	60	sodium	sodium	NOUN
admet-1427	55	61	dihydrogen	dihydrogen	NOUN
admet-1427	55	62	phosphate	phosphate	NOUN
admet-1427	55	63	dihydrate	dihydrate	NOUN
admet-1427	55	64	,	,	PUNCT
admet-1427	55	65	sodium	sodium	NOUN
admet-1427	55	66	chloride	chloride	NOUN
admet-1427	55	67	,	,	PUNCT
admet-1427	55	68	sodium	sodium	NOUN
admet-1427	55	69	hydroxide	hydroxide	NOUN
admet-1427	55	70	,	,	PUNCT
admet-1427	55	71	decane	decane	NOUN
admet-1427	55	72	,	,	PUNCT
admet-1427	55	73	8	8	NUM
admet-1427	55	74	m	m	NOUN
admet-1427	55	75	naoh	naoh	NOUN
admet-1427	55	76	,	,	PUNCT
admet-1427	55	77	and	and	CCONJ
admet-1427	55	78	0.1	0.1	NUM
admet-1427	55	79	vol%	vol%	ADJ
admet-1427	55	80	trifluoroacetic	trifluoroacetic	ADJ
admet-1427	55	81	acidadmet	acidadmet	NOUN
admet-1427	55	82	&	&	CCONJ
admet-1427	55	83	dmpk	dmpk	PROPN
admet-1427	55	84	10(4	10(4	NUM
admet-1427	55	85	)	)	PUNCT
admet-1427	55	86	(	(	PUNCT
admet-1427	55	87	2022	2022	NUM
admet-1427	55	88	)	)	PUNCT
admet-1427	55	89	289	289	NUM
admet-1427	55	90	-	-	PUNCT
admet-1427	55	91	297	297	NUM
admet-1427	55	92	artificial	artificial	ADJ
admet-1427	55	93	membrane	membrane	NOUN
admet-1427	55	94	permeation	permeation	NOUN
admet-1427	55	95	of	of	ADP
admet-1427	55	96	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	55	97	doi	doi	NOUN
admet-1427	55	98	:	:	PUNCT
admet-1427	55	99	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	NUM
admet-1427	55	100	291	291	NUM
admet-1427	55	101	acetonitrile	acetonitrile	NOUN
admet-1427	55	102	were	be	AUX
admet-1427	55	103	purchased	purchase	VERB
admet-1427	55	104	from	from	ADP
admet-1427	55	105	wako	wako	PROPN
admet-1427	55	106	pure	pure	ADJ
admet-1427	55	107	chemical	chemical	NOUN
admet-1427	55	108	industries	industry	NOUN
admet-1427	55	109	,	,	PUNCT
admet-1427	55	110	ltd	ltd	PROPN
admet-1427	55	111	(	(	PUNCT
admet-1427	55	112	osaka	osaka	PROPN
admet-1427	55	113	,	,	PUNCT
admet-1427	55	114	japan	japan	PROPN
admet-1427	55	115	)	)	PUNCT
admet-1427	55	116	.	.	PUNCT
admet-1427	56	1	ciprofloxacin	ciprofloxacin	PROPN
admet-1427	56	2	hydrochloride	hydrochloride	NOUN
admet-1427	56	3	monohydrate	monohydrate	NOUN
admet-1427	56	4	(	(	PUNCT
admet-1427	56	5	cpfx	cpfx	NOUN
admet-1427	56	6	)	)	PUNCT
admet-1427	56	7	,	,	PUNCT
admet-1427	56	8	levofloxacin	levofloxacin	PROPN
admet-1427	56	9	(	(	PUNCT
admet-1427	56	10	lvfx	lvfx	NOUN
admet-1427	56	11	)	)	PUNCT
admet-1427	56	12	,	,	PUNCT
admet-1427	56	13	enoxacin	enoxacin	NUM
admet-1427	56	14	sesquihydrate	sesquihydrate	NOUN
admet-1427	56	15	(	(	PUNCT
admet-1427	56	16	enx	enx	NOUN
admet-1427	56	17	)	)	PUNCT
admet-1427	56	18	,	,	PUNCT
admet-1427	56	19	fleroxacin	fleroxacin	PROPN
admet-1427	56	20	(	(	PUNCT
admet-1427	56	21	flrx	flrx	PROPN
admet-1427	56	22	)	)	PUNCT
admet-1427	56	23	,	,	PUNCT
admet-1427	56	24	and	and	CCONJ
admet-1427	56	25	prulifloxacin	prulifloxacin	PROPN
admet-1427	56	26	(	(	PUNCT
admet-1427	56	27	pufx	pufx	PROPN
admet-1427	56	28	)	)	PUNCT
admet-1427	56	29	were	be	AUX
admet-1427	56	30	purchased	purchase	VERB
admet-1427	56	31	from	from	ADP
admet-1427	56	32	tci	tci	PROPN
admet-1427	56	33	(	(	PUNCT
admet-1427	56	34	tokyo	tokyo	PROPN
admet-1427	56	35	,	,	PUNCT
admet-1427	56	36	japan	japan	PROPN
admet-1427	56	37	)	)	PUNCT
admet-1427	56	38	.	.	PUNCT
admet-1427	57	1	gatifloxacin	gatifloxacin	PROPN
admet-1427	57	2	(	(	PUNCT
admet-1427	57	3	gflx	gflx	VERB
admet-1427	57	4	)	)	PUNCT
admet-1427	57	5	and	and	CCONJ
admet-1427	57	6	sparfloxacin	sparfloxacin	PROPN
admet-1427	57	7	(	(	PUNCT
admet-1427	57	8	spfx	spfx	PROPN
admet-1427	57	9	)	)	PUNCT
admet-1427	57	10	were	be	AUX
admet-1427	57	11	purchased	purchase	VERB
admet-1427	57	12	from	from	ADP
admet-1427	57	13	funakoshi	funakoshi	PROPN
admet-1427	57	14	co.	co.	PROPN
admet-1427	57	15	,	,	PUNCT
admet-1427	57	16	ltd	ltd	PROPN
admet-1427	57	17	(	(	PUNCT
admet-1427	57	18	tokyo	tokyo	PROPN
admet-1427	57	19	,	,	PUNCT
admet-1427	57	20	japan	japan	PROPN
admet-1427	57	21	)	)	PUNCT
admet-1427	57	22	.	.	PUNCT
admet-1427	58	1	moxifloxacin	moxifloxacin	PROPN
admet-1427	58	2	(	(	PUNCT
admet-1427	58	3	mflx	mflx	NOUN
admet-1427	58	4	)	)	PUNCT
admet-1427	58	5	was	be	AUX
admet-1427	58	6	purchased	purchase	VERB
admet-1427	58	7	from	from	ADP
admet-1427	58	8	combiblocks	combiblocks	PROPN
admet-1427	58	9	inc	inc	PROPN
admet-1427	58	10	.	.	PROPN
admet-1427	58	11	(	(	PUNCT
admet-1427	58	12	san	san	PROPN
admet-1427	58	13	diego	diego	PROPN
admet-1427	58	14	,	,	PUNCT
admet-1427	58	15	usa	usa	PROPN
admet-1427	58	16	)	)	PUNCT
admet-1427	58	17	.	.	PUNCT
admet-1427	59	1	2	2	NUM
admet-1427	59	2	-	-	PUNCT
admet-1427	59	3	morpholinoethanesulfonic	morpholinoethanesulfonic	ADJ
admet-1427	59	4	acid	acid	NOUN
admet-1427	59	5	(	(	PUNCT
admet-1427	59	6	mes	me	NOUN
admet-1427	59	7	)	)	PUNCT
admet-1427	59	8	was	be	AUX
admet-1427	59	9	purchased	purchase	VERB
admet-1427	59	10	from	from	ADP
admet-1427	59	11	dojindo	dojindo	ADJ
admet-1427	59	12	laboratories	laboratory	NOUN
admet-1427	59	13	(	(	PUNCT
admet-1427	59	14	tokyo	tokyo	PROPN
admet-1427	59	15	,	,	PUNCT
admet-1427	59	16	japan	japan	PROPN
admet-1427	59	17	)	)	PUNCT
admet-1427	59	18	.	.	PUNCT
admet-1427	60	1	0.1	0.1	NUM
admet-1427	60	2	vol%	vol%	VERB
admet-1427	60	3	trifluoroacetic	trifluoroacetic	ADJ
admet-1427	60	4	acid	acid	NOUN
admet-1427	60	5	-	-	PUNCT
admet-1427	60	6	distilled	distil	VERB
admet-1427	60	7	water	water	NOUN
admet-1427	60	8	was	be	AUX
admet-1427	60	9	purchased	purchase	VERB
admet-1427	60	10	from	from	ADP
admet-1427	60	11	kanto	kanto	PROPN
admet-1427	60	12	chemical	chemical	PROPN
admet-1427	60	13	co.	co.	PROPN
admet-1427	60	14	,	,	PUNCT
admet-1427	60	15	inc	inc	PROPN
admet-1427	60	16	(	(	PUNCT
admet-1427	60	17	tokyo	tokyo	PROPN
admet-1427	60	18	,	,	PUNCT
admet-1427	60	19	japan	japan	PROPN
admet-1427	60	20	)	)	PUNCT
admet-1427	60	21	.	.	PUNCT
admet-1427	61	1	soybean	soybean	NOUN
admet-1427	61	2	lecithin	lecithin	NOUN
admet-1427	61	3	was	be	AUX
admet-1427	61	4	provided	provide	VERB
admet-1427	61	5	by	by	ADP
admet-1427	61	6	tsuji	tsuji	PROPN
admet-1427	61	7	oil	oil	PROPN
admet-1427	61	8	mills	mills	PROPN
admet-1427	61	9	co.	co.	PROPN
admet-1427	61	10	,	,	PUNCT
admet-1427	61	11	ltd	ltd	PROPN
admet-1427	61	12	(	(	PUNCT
admet-1427	61	13	mie	mie	PROPN
admet-1427	61	14	,	,	PUNCT
admet-1427	61	15	japan	japan	PROPN
admet-1427	61	16	)	)	PUNCT
admet-1427	61	17	(	(	PUNCT
admet-1427	61	18	slp	slp	PROPN
admet-1427	61	19	-	-	PUNCT
admet-1427	61	20	white	white	ADJ
admet-1427	61	21	,	,	PUNCT
admet-1427	61	22	phosphatidylcholine	phosphatidylcholine	NOUN
admet-1427	61	23	(	(	PUNCT
admet-1427	61	24	24	24	NUM
admet-1427	61	25	-	-	SYM
admet-1427	61	26	32	32	NUM
admet-1427	61	27	%	%	NOUN
admet-1427	61	28	)	)	PUNCT
admet-1427	61	29	,	,	PUNCT
admet-1427	61	30	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
admet-1427	61	31	(	(	PUNCT
admet-1427	61	32	20	20	NUM
admet-1427	61	33	-	-	SYM
admet-1427	61	34	28	28	NUM
admet-1427	61	35	%	%	NOUN
admet-1427	61	36	)	)	PUNCT
admet-1427	61	37	,	,	PUNCT
admet-1427	61	38	phosphatidylinositol	phosphatidylinositol	NOUN
admet-1427	61	39	(	(	PUNCT
admet-1427	61	40	12	12	NUM
admet-1427	61	41	-	-	SYM
admet-1427	61	42	20	20	NUM
admet-1427	61	43	%	%	NOUN
admet-1427	61	44	)	)	PUNCT
admet-1427	61	45	,	,	PUNCT
admet-1427	61	46	phosphatidic	phosphatidic	ADJ
admet-1427	61	47	acid	acid	NOUN
admet-1427	61	48	(	(	PUNCT
admet-1427	61	49	8	8	NUM
admet-1427	61	50	-	-	SYM
admet-1427	61	51	15	15	NUM
admet-1427	61	52	%	%	NOUN
admet-1427	61	53	)	)	PUNCT
admet-1427	61	54	,	,	PUNCT
admet-1427	61	55	and	and	CCONJ
admet-1427	61	56	lysophosphatidylcholines	lysophosphatidylcholine	NOUN
admet-1427	61	57	(	(	PUNCT
admet-1427	61	58	1	1	NUM
admet-1427	61	59	-	-	SYM
admet-1427	61	60	5	5	NUM
admet-1427	61	61	%	%	NOUN
admet-1427	61	62	)	)	PUNCT
admet-1427	61	63	(	(	PUNCT
admet-1427	61	64	based	base	VERB
admet-1427	61	65	on	on	ADP
admet-1427	61	66	the	the	DET
admet-1427	61	67	product	product	NOUN
admet-1427	61	68	information	information	NOUN
admet-1427	61	69	provided	provide	VERB
admet-1427	61	70	by	by	ADP
admet-1427	61	71	the	the	DET
admet-1427	61	72	manufacturer	manufacturer	NOUN
admet-1427	61	73	)	)	PUNCT
admet-1427	61	74	)	)	PUNCT
admet-1427	61	75	.	.	PUNCT
admet-1427	62	1	table	table	NOUN
admet-1427	62	2	1	1	NUM
admet-1427	62	3	.	.	PUNCT
admet-1427	62	4	physicochemical	physicochemical	ADJ
admet-1427	62	5	properties	property	NOUN
admet-1427	62	6	of	of	ADP
admet-1427	62	7	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	62	8	used	use	VERB
admet-1427	62	9	in	in	ADP
admet-1427	62	10	this	this	DET
admet-1427	62	11	study	study	NOUN
admet-1427	62	12	drug	drug	NOUN
admet-1427	62	13	mw	mw	X
admet-1427	62	14	pka	pka	NOUN
admet-1427	62	15	log	log	NOUN
admet-1427	62	16	d	d	PROPN
admet-1427	62	17	(	(	PUNCT
admet-1427	62	18	ph	ph	NOUN
admet-1427	62	19	6.5)a	6.5)a	NUM
admet-1427	62	20	uv	uv	NOUN
admet-1427	62	21	(	(	PUNCT
admet-1427	62	22	nm	nm	NOUN
admet-1427	62	23	)	)	PUNCT
admet-1427	62	24	pka	pka	PROPN
admet-1427	62	25	ref	ref	NOUN
admet-1427	62	26	.	.	PUNCT
admet-1427	63	1	ciprofloxacin	ciprofloxacin	NOUN
admet-1427	63	2	(	(	PUNCT
admet-1427	63	3	cpfx	cpfx	NOUN
admet-1427	63	4	)	)	PUNCT
admet-1427	63	5	331	331	NUM
admet-1427	63	6	6.1	6.1	NUM
admet-1427	63	7	,	,	PUNCT
admet-1427	63	8	8.7	8.7	NUM
admet-1427	63	9	-1.38	-1.38	NUM
admet-1427	63	10	±	±	NUM
admet-1427	63	11	0.15	0.15	NUM
admet-1427	63	12	335	335	NUM
admet-1427	64	1	[	[	X
admet-1427	64	2	12	12	NUM
admet-1427	64	3	]	]	PUNCT
admet-1427	64	4	enoxacin	enoxacin	PROPN
admet-1427	64	5	(	(	PUNCT
admet-1427	64	6	enx	enx	NOUN
admet-1427	64	7	)	)	PUNCT
admet-1427	64	8	320	320	NUM
admet-1427	64	9	6.3	6.3	NUM
admet-1427	64	10	,	,	PUNCT
admet-1427	64	11	8.7	8.7	NUM
admet-1427	64	12	-1.20	-1.20	NUM
admet-1427	64	13	±	±	NUM
admet-1427	64	14	0.39	0.39	NUM
admet-1427	64	15	330	330	NUM
admet-1427	65	1	[	[	X
admet-1427	65	2	12	12	NUM
admet-1427	65	3	]	]	X
admet-1427	65	4	fleroxacin	fleroxacin	PROPN
admet-1427	65	5	(	(	PUNCT
admet-1427	65	6	flrx	flrx	PROPN
admet-1427	65	7	)	)	PUNCT
admet-1427	65	8	369	369	NUM
admet-1427	65	9	5.5	5.5	NUM
admet-1427	65	10	,	,	PUNCT
admet-1427	65	11	8.1	8.1	NUM
admet-1427	65	12	-0.55	-0.55	NUM
admet-1427	65	13	±	±	NUM
admet-1427	65	14	0.10	0.10	NUM
admet-1427	65	15	283	283	NUM
admet-1427	65	16	[	[	X
admet-1427	65	17	12	12	NUM
admet-1427	65	18	]	]	X
admet-1427	65	19	gatifloxacin	gatifloxacin	NOUN
admet-1427	65	20	(	(	PUNCT
admet-1427	65	21	gflx	gflx	VERB
admet-1427	65	22	)	)	PUNCT
admet-1427	65	23	375	375	NUM
admet-1427	65	24	5.7	5.7	NUM
admet-1427	65	25	,	,	PUNCT
admet-1427	65	26	8.7	8.7	NUM
admet-1427	65	27	-0.97	-0.97	NOUN
admet-1427	65	28	±	±	NUM
admet-1427	65	29	0.04	0.04	NUM
admet-1427	65	30	330	330	NUM
admet-1427	65	31	[	[	SYM
admet-1427	65	32	13	13	NUM
admet-1427	65	33	]	]	SYM
admet-1427	65	34	levofloxacin	levofloxacin	NOUN
admet-1427	65	35	(	(	PUNCT
admet-1427	65	36	lvfx	lvfx	NOUN
admet-1427	65	37	)	)	PUNCT
admet-1427	65	38	361	361	NUM
admet-1427	65	39	6.1	6.1	NUM
admet-1427	65	40	,	,	PUNCT
admet-1427	65	41	8.2	8.2	NUM
admet-1427	65	42	-0.56	-0.56	NUM
admet-1427	65	43	±	±	NUM
admet-1427	65	44	0.11	0.11	NUM
admet-1427	65	45	335	335	NUM
admet-1427	66	1	[	[	X
admet-1427	66	2	14	14	NUM
admet-1427	66	3	]	]	SYM
admet-1427	66	4	moxifloxacin	moxifloxacin	PROPN
admet-1427	66	5	(	(	PUNCT
admet-1427	66	6	mflx	mflx	PROPN
admet-1427	66	7	)	)	PUNCT
admet-1427	66	8	401	401	NUM
admet-1427	66	9	6.4	6.4	NUM
admet-1427	66	10	,	,	PUNCT
admet-1427	66	11	9.5	9.5	NUM
admet-1427	66	12	-0.72	-0.72	NUM
admet-1427	66	13	±	±	NUM
admet-1427	66	14	0.38	0.38	NUM
admet-1427	66	15	350	350	NUM
admet-1427	67	1	[	[	X
admet-1427	67	2	12	12	NUM
admet-1427	67	3	]	]	SYM
admet-1427	67	4	norfloxacin	norfloxacin	PROPN
admet-1427	67	5	(	(	PUNCT
admet-1427	67	6	nflx	nflx	PROPN
admet-1427	67	7	)	)	PUNCT
admet-1427	67	8	319	319	NUM
admet-1427	67	9	6.3	6.3	NUM
admet-1427	67	10	,	,	PUNCT
admet-1427	67	11	8.4	8.4	NUM
admet-1427	67	12	-1.35	-1.35	NUM
admet-1427	67	13	±	±	NUM
admet-1427	67	14	0.17	0.17	NUM
admet-1427	67	15	280	280	NUM
admet-1427	68	1	[	[	X
admet-1427	68	2	12	12	NUM
admet-1427	68	3	]	]	X
admet-1427	68	4	ofloxacin	ofloxacin	PROPN
admet-1427	68	5	(	(	PUNCT
admet-1427	68	6	oflx	oflx	ADJ
admet-1427	68	7	)	)	PUNCT
admet-1427	68	8	361	361	NUM
admet-1427	68	9	6.1	6.1	NUM
admet-1427	68	10	,	,	PUNCT
admet-1427	68	11	8.2	8.2	NUM
admet-1427	68	12	-0.55	-0.55	NUM
admet-1427	68	13	±	±	NUM
admet-1427	68	14	0.12	0.12	NUM
admet-1427	68	15	330	330	NUM
admet-1427	68	16	[	[	X
admet-1427	68	17	12	12	NUM
admet-1427	68	18	]	]	X
admet-1427	68	19	prulifloxacin	prulifloxacin	PROPN
admet-1427	68	20	(	(	PUNCT
admet-1427	68	21	pufx	pufx	PROPN
admet-1427	68	22	)	)	PUNCT
admet-1427	68	23	461	461	NUM
admet-1427	68	24	5.6	5.6	NUM
admet-1427	68	25	,	,	PUNCT
admet-1427	68	26	6.3	6.3	NUM
admet-1427	68	27	0.86	0.86	NUM
admet-1427	68	28	±	±	NUM
admet-1427	68	29	0.02	0.02	NUM
admet-1427	68	30	283	283	NUM
admet-1427	69	1	[	[	X
admet-1427	69	2	15	15	NUM
admet-1427	69	3	]	]	X
admet-1427	69	4	sparfloxacin	sparfloxacin	PROPN
admet-1427	69	5	(	(	PUNCT
admet-1427	69	6	spfx	spfx	PROPN
admet-1427	69	7	)	)	PUNCT
admet-1427	69	8	392	392	NUM
admet-1427	69	9	6.3	6.3	NUM
admet-1427	69	10	,	,	PUNCT
admet-1427	69	11	8.8	8.8	NUM
admet-1427	69	12	-0.26	-0.26	NOUN
admet-1427	69	13	±	±	NUM
admet-1427	69	14	0.03	0.03	NUM
admet-1427	69	15	300	300	NUM
admet-1427	70	1	[	[	X
admet-1427	70	2	12	12	NUM
admet-1427	70	3	]	]	X
admet-1427	70	4	tosufloxacin	tosufloxacin	PROPN
admet-1427	70	5	(	(	PUNCT
admet-1427	70	6	tflx	tflx	PROPN
admet-1427	70	7	)	)	PUNCT
admet-1427	70	8	404	404	NUM
admet-1427	70	9	5.8	5.8	NUM
admet-1427	70	10	,	,	PUNCT
admet-1427	70	11	8.7	8.7	NUM
admet-1427	70	12	-0.14	-0.14	NUM
admet-1427	70	13	±	±	NUM
admet-1427	70	14	0.10	0.10	NUM
admet-1427	70	15	270	270	NUM
admet-1427	71	1	[	[	X
admet-1427	71	2	16	16	NUM
admet-1427	71	3	]	]	PUNCT
admet-1427	71	4	a	a	DET
admet-1427	71	5	measured	measure	VERB
admet-1427	71	6	in	in	ADP
admet-1427	71	7	this	this	DET
admet-1427	71	8	study	study	NOUN
admet-1427	71	9	.	.	PUNCT
admet-1427	72	1	mean	mean	VERB
admet-1427	72	2	±	±	NUM
admet-1427	72	3	sd	sd	NOUN
admet-1427	72	4	(	(	PUNCT
admet-1427	72	5	n	n	NOUN
admet-1427	72	6	=	=	SYM
admet-1427	72	7	3	3	NUM
admet-1427	72	8	)	)	PUNCT
admet-1427	72	9	methods	method	NOUN
admet-1427	72	10	pampa	pampa	PROPN
admet-1427	72	11	assay	assay	VERB
admet-1427	72	12	the	the	DET
admet-1427	72	13	pampa	pampa	PROPN
admet-1427	72	14	sandwich	sandwich	NOUN
admet-1427	72	15	consisted	consist	VERB
admet-1427	72	16	of	of	ADP
admet-1427	72	17	a	a	DET
admet-1427	72	18	96	96	NUM
admet-1427	72	19	-	-	PUNCT
admet-1427	72	20	well	well	NOUN
admet-1427	72	21	filter	filter	NOUN
admet-1427	72	22	plate	plate	NOUN
admet-1427	72	23	(	(	PUNCT
admet-1427	72	24	hydrophobic	hydrophobic	NOUN
admet-1427	72	25	pvdf	pvdf	PROPN
admet-1427	72	26	,	,	PUNCT
admet-1427	72	27	0.45	0.45	NUM
admet-1427	72	28	μm	μm	NOUN
admet-1427	72	29	)	)	PUNCT
admet-1427	72	30	and	and	CCONJ
admet-1427	72	31	a	a	DET
admet-1427	72	32	pampa	pampa	NOUN
admet-1427	72	33	acceptor	acceptor	NOUN
admet-1427	72	34	plate	plate	NOUN
admet-1427	72	35	(	(	PUNCT
admet-1427	72	36	merck	merck	PROPN
admet-1427	72	37	millipore	millipore	PROPN
admet-1427	72	38	,	,	PUNCT
admet-1427	72	39	ma	ma	PROPN
admet-1427	72	40	,	,	PUNCT
admet-1427	72	41	usa	usa	PROPN
admet-1427	72	42	)	)	PUNCT
admet-1427	72	43	.	.	PUNCT
admet-1427	73	1	the	the	DET
admet-1427	73	2	acceptor	acceptor	NOUN
admet-1427	73	3	plate	plate	NOUN
admet-1427	73	4	was	be	AUX
admet-1427	73	5	filled	fill	VERB
admet-1427	73	6	with	with	ADP
admet-1427	73	7	300	300	NUM
admet-1427	73	8	μl	μl	ADP
admet-1427	73	9	of	of	ADP
admet-1427	73	10	a	a	DET
admet-1427	73	11	50	50	NUM
admet-1427	73	12	mm	mm	NOUN
admet-1427	73	13	mes	me	NOUN
admet-1427	73	14	buffer	buffer	NOUN
admet-1427	73	15	solution	solution	NOUN
admet-1427	73	16	(	(	PUNCT
admet-1427	73	17	ph	ph	NOUN
admet-1427	73	18	6.5	6.5	NUM
admet-1427	73	19	)	)	PUNCT
admet-1427	73	20	.	.	PUNCT
admet-1427	74	1	the	the	DET
admet-1427	74	2	filter	filter	NOUN
admet-1427	74	3	bottom	bottom	NOUN
admet-1427	74	4	of	of	ADP
admet-1427	74	5	the	the	DET
admet-1427	74	6	donor	donor	NOUN
admet-1427	74	7	well	well	ADV
admet-1427	74	8	was	be	AUX
admet-1427	74	9	coated	coat	VERB
admet-1427	74	10	with	with	ADP
admet-1427	74	11	5	5	NUM
admet-1427	74	12	μl	μl	ADP
admet-1427	74	13	of	of	ADP
admet-1427	74	14	a	a	DET
admet-1427	74	15	10	10	NUM
admet-1427	74	16	%	%	NOUN
admet-1427	74	17	soybean	soybean	NOUN
admet-1427	74	18	lecithin	lecithin	NOUN
admet-1427	74	19	(	(	PUNCT
admet-1427	74	20	sl	sl	NOUN
admet-1427	74	21	)	)	PUNCT
admet-1427	74	22	–	–	PUNCT
admet-1427	74	23	decane	decane	NOUN
admet-1427	74	24	solution	solution	NOUN
admet-1427	74	25	prepared	prepare	VERB
admet-1427	74	26	in	in	ADP
admet-1427	74	27	our	our	PRON
admet-1427	74	28	laboratory	laboratory	NOUN
admet-1427	74	29	[	[	X
admet-1427	74	30	11	11	NUM
admet-1427	74	31	]	]	PUNCT
admet-1427	74	32	.	.	PUNCT
admet-1427	75	1	the	the	DET
admet-1427	75	2	soybean	soybean	NOUN
admet-1427	75	3	lecithin	lecithin	NOUN
admet-1427	75	4	–	–	PUNCT
admet-1427	75	5	decane	decane	NOUN
admet-1427	75	6	membrane	membrane	NOUN
admet-1427	75	7	(	(	PUNCT
admet-1427	75	8	sl	sl	INTJ
admet-1427	75	9	–	–	PUNCT
admet-1427	75	10	pampa	pampa	PROPN
admet-1427	75	11	)	)	PUNCT
admet-1427	75	12	was	be	AUX
admet-1427	75	13	used	use	VERB
admet-1427	75	14	because	because	SCONJ
admet-1427	75	15	it	it	PRON
admet-1427	75	16	most	most	ADV
admet-1427	75	17	likely	likely	ADV
admet-1427	75	18	mimics	mimic	VERB
admet-1427	75	19	the	the	DET
admet-1427	75	20	intestinal	intestinal	ADJ
admet-1427	75	21	membrane	membrane	NOUN
admet-1427	76	1	[	[	X
admet-1427	76	2	17	17	NUM
admet-1427	76	3	]	]	PUNCT
admet-1427	76	4	.	.	PUNCT
admet-1427	77	1	a	a	DET
admet-1427	77	2	drug	drug	NOUN
admet-1427	77	3	solution	solution	NOUN
admet-1427	77	4	(	(	PUNCT
admet-1427	77	5	0.5	0.5	NUM
admet-1427	77	6	mm	mm	NOUN
admet-1427	77	7	in	in	ADP
admet-1427	77	8	ph	ph	ADJ
admet-1427	77	9	6.5	6.5	NUM
admet-1427	77	10	50	50	NUM
admet-1427	77	11	mm	mm	NOUN
admet-1427	77	12	mes	me	NOUN
admet-1427	77	13	buffer	buffer	NOUN
admet-1427	77	14	,	,	PUNCT
admet-1427	77	15	200	200	NUM
admet-1427	77	16	μl	μl	NUM
admet-1427	77	17	)	)	PUNCT
admet-1427	77	18	with	with	ADP
admet-1427	77	19	or	or	CCONJ
admet-1427	77	20	without	without	ADP
admet-1427	77	21	a	a	DET
admet-1427	77	22	metal	metal	NOUN
admet-1427	77	23	ion	ion	NOUN
admet-1427	77	24	was	be	AUX
admet-1427	77	25	added	add	VERB
admet-1427	77	26	to	to	ADP
admet-1427	77	27	the	the	DET
admet-1427	77	28	donor	donor	NOUN
admet-1427	77	29	compartment	compartment	NOUN
admet-1427	77	30	.	.	PUNCT
admet-1427	78	1	the	the	DET
admet-1427	78	2	pampa	pampa	PROPN
admet-1427	78	3	sandwich	sandwich	NOUN
admet-1427	78	4	was	be	AUX
admet-1427	78	5	then	then	ADV
admet-1427	78	6	incubated	incubate	VERB
admet-1427	78	7	at	at	ADP
admet-1427	78	8	37	37	NUM
admet-1427	78	9	°	°	NOUN
admet-1427	78	10	c	c	NOUN
admet-1427	78	11	for	for	ADP
admet-1427	78	12	3	3	NUM
admet-1427	78	13	h	h	NOUN
admet-1427	78	14	without	without	ADP
admet-1427	78	15	stirring	stir	VERB
admet-1427	78	16	.	.	PUNCT
admet-1427	79	1	after	after	ADP
admet-1427	79	2	incubation	incubation	NOUN
admet-1427	79	3	,	,	PUNCT
admet-1427	79	4	150	150	NUM
admet-1427	79	5	μl	μl	PRON
admet-1427	79	6	of	of	ADP
admet-1427	79	7	both	both	CCONJ
admet-1427	79	8	the	the	DET
admet-1427	79	9	donor	donor	NOUN
admet-1427	79	10	and	and	CCONJ
admet-1427	79	11	acceptor	acceptor	NOUN
admet-1427	79	12	solutions	solution	NOUN
admet-1427	79	13	were	be	AUX
admet-1427	79	14	transferred	transfer	VERB
admet-1427	79	15	to	to	ADP
admet-1427	79	16	a	a	DET
admet-1427	79	17	uv	uv	NOUN
admet-1427	79	18	plate	plate	NOUN
admet-1427	79	19	.	.	PUNCT
admet-1427	80	1	the	the	DET
admet-1427	80	2	concentrations	concentration	NOUN
admet-1427	80	3	of	of	ADP
admet-1427	80	4	fqs	fqs	PROPN
admet-1427	80	5	were	be	AUX
admet-1427	80	6	measured	measure	VERB
admet-1427	80	7	by	by	ADP
admet-1427	80	8	uv	uv	NOUN
admet-1427	80	9	absorption	absorption	NOUN
admet-1427	80	10	except	except	SCONJ
admet-1427	80	11	for	for	ADP
admet-1427	80	12	tflx	tflx	PROPN
admet-1427	80	13	(	(	PUNCT
admet-1427	80	14	table	table	NOUN
admet-1427	80	15	1	1	NUM
admet-1427	80	16	)	)	PUNCT
admet-1427	80	17	.	.	PUNCT
admet-1427	81	1	the	the	DET
admet-1427	81	2	concentration	concentration	NOUN
admet-1427	81	3	of	of	ADP
admet-1427	81	4	tflx	tflx	PROPN
admet-1427	81	5	was	be	AUX
admet-1427	81	6	measured	measure	VERB
admet-1427	81	7	by	by	ADP
admet-1427	81	8	hplc	hplc	NOUN
admet-1427	81	9	(	(	PUNCT
admet-1427	81	10	lc-20ad	lc-20ad	PROPN
admet-1427	81	11	,	,	PUNCT
admet-1427	81	12	shimazu	shimazu	PROPN
admet-1427	81	13	corporation	corporation	PROPN
admet-1427	81	14	,	,	PUNCT
admet-1427	81	15	kyoto	kyoto	PROPN
admet-1427	81	16	,	,	PUNCT
admet-1427	81	17	japan	japan	PROPN
admet-1427	81	18	)	)	PUNCT
admet-1427	81	19	(	(	PUNCT
admet-1427	81	20	column	column	NOUN
admet-1427	81	21	:	:	PUNCT
admet-1427	81	22	zorbax	zorbax	PROPN
admet-1427	81	23	eclipse	eclipse	PROPN
admet-1427	81	24	plus	plus	CCONJ
admet-1427	81	25	c18	c18	PROPN
admet-1427	81	26	narrow	narrow	ADJ
admet-1427	81	27	bore	bore	PROPN
admet-1427	81	28	rr	rr	PROPN
admet-1427	81	29	2.1×50	2.1×50	NUM
admet-1427	81	30	mm	mm	PROPN
admet-1427	81	31	column	column	NOUN
admet-1427	81	32	with	with	ADP
admet-1427	81	33	3.5	3.5	NUM
admet-1427	81	34	µm	µm	ADP
admet-1427	81	35	particles	particle	NOUN
admet-1427	81	36	(	(	PUNCT
admet-1427	81	37	agilent	agilent	PROPN
admet-1427	81	38	technologies	technology	NOUN
admet-1427	81	39	,	,	PUNCT
admet-1427	81	40	ca	ca	NOUN
admet-1427	81	41	)	)	PUNCT
admet-1427	81	42	;	;	PUNCT
admet-1427	81	43	flow	flow	NOUN
admet-1427	81	44	rate	rate	NOUN
admet-1427	81	45	:	:	PUNCT
admet-1427	81	46	0.60	0.60	NUM
admet-1427	81	47	ml	ml	NOUN
admet-1427	81	48	/	/	SYM
admet-1427	81	49	min	min	NOUN
admet-1427	81	50	;	;	PUNCT
admet-1427	81	51	mobile	mobile	ADJ
admet-1427	81	52	phase	phase	NOUN
admet-1427	81	53	:	:	PUNCT
admet-1427	81	54	20	20	NUM
admet-1427	81	55	%	%	NOUN
admet-1427	81	56	0.1	0.1	NUM
admet-1427	81	57	vol%	vol%	ADJ
admet-1427	81	58	trifluoroacetic	trifluoroacetic	ADJ
admet-1427	81	59	acid	acid	NOUN
admet-1427	81	60	-	-	PUNCT
admet-1427	81	61	acetonitrile	acetonitrile	NOUN
admet-1427	81	62	,	,	PUNCT
admet-1427	81	63	80	80	NUM
admet-1427	81	64	%	%	NOUN
admet-1427	81	65	0.1	0.1	NUM
admet-1427	81	66	vol%	vol%	ADJ
admet-1427	81	67	trifluoroacetic	trifluoroacetic	ADJ
admet-1427	81	68	acid	acid	NOUN
admet-1427	81	69	-	-	PUNCT
admet-1427	81	70	distilled	distil	VERB
admet-1427	81	71	water	water	NOUN
admet-1427	81	72	(	(	PUNCT
admet-1427	81	73	isocratic	isocratic	ADJ
admet-1427	81	74	elution	elution	NOUN
admet-1427	81	75	)	)	PUNCT
admet-1427	81	76	;	;	PUNCT
admet-1427	81	77	detection	detection	NOUN
admet-1427	81	78	wavelength	wavelength	NOUN
admet-1427	81	79	:	:	PUNCT
admet-1427	81	80	270	270	NUM
admet-1427	81	81	nm	nm	NOUN
admet-1427	81	82	;	;	PUNCT
admet-1427	81	83	column	column	NOUN
admet-1427	81	84	temperature	temperature	NOUN
admet-1427	81	85	:	:	PUNCT
admet-1427	81	86	40	40	NUM
admet-1427	81	87	°	°	NUM
admet-1427	81	88	c	c	NOUN
admet-1427	81	89	;	;	PUNCT
admet-1427	81	90	injection	injection	NOUN
admet-1427	81	91	volume	volume	NOUN
admet-1427	81	92	:	:	PUNCT
admet-1427	81	93	10	10	NUM
admet-1427	81	94	µl	µl	NOUN
admet-1427	81	95	)	)	PUNCT
admet-1427	81	96	.	.	PUNCT
admet-1427	82	1	the	the	DET
admet-1427	82	2	pampa	pampa	PROPN
admet-1427	82	3	permeability	permeability	NOUN
admet-1427	82	4	(	(	PUNCT
admet-1427	82	5	pe	pe	INTJ
admet-1427	82	6	)	)	PUNCT
admet-1427	82	7	was	be	AUX
admet-1427	82	8	measured	measure	VERB
admet-1427	82	9	in	in	ADP
admet-1427	82	10	triplicate	triplicate	NOUN
admet-1427	82	11	.	.	PUNCT
admet-1427	83	1	the	the	DET
admet-1427	83	2	pe	pe	PROPN
admet-1427	83	3	value	value	NOUN
admet-1427	83	4	was	be	AUX
admet-1427	83	5	calculated	calculate	VERB
admet-1427	83	6	by	by	ADP
admet-1427	83	7	the	the	DET
admet-1427	83	8	following	follow	VERB
admet-1427	83	9	equations	equation	NOUN
admet-1427	83	10	[	[	X
admet-1427	83	11	17	17	NUM
admet-1427	83	12	]	]	PUNCT
admet-1427	83	13	.	.	PUNCT
admet-1427	84	1	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	VERB
admet-1427	84	2	nakatani	nakatani	ADJ
admet-1427	84	3	and	and	CCONJ
admet-1427	84	4	sugano	sugano	ADJ
admet-1427	84	5	admet	admet	PROPN
admet-1427	84	6	&	&	CCONJ
admet-1427	84	7	dmpk	dmpk	PROPN
admet-1427	84	8	10(4	10(4	NUM
admet-1427	84	9	)	)	PUNCT
admet-1427	84	10	(	(	PUNCT
admet-1427	84	11	2022	2022	NUM
admet-1427	84	12	)	)	PUNCT
admet-1427	84	13	289	289	NUM
admet-1427	84	14	-	-	SYM
admet-1427	84	15	297	297	NUM
admet-1427	84	16	292	292	NUM
admet-1427	85	1	𝑃e	𝑃e	PROPN
admet-1427	85	2	=	=	PUNCT
admet-1427	86	1	−	−	PROPN
admet-1427	86	2	2.303𝑉d	2.303𝑉d	NUM
admet-1427	86	3	𝐴∙𝑡	𝐴∙𝑡	PROPN
admet-1427	86	4	(	(	PUNCT
admet-1427	86	5	1	1	NUM
admet-1427	86	6	1+𝑟𝑣	1+𝑟𝑣	NUM
admet-1427	86	7	)	)	PUNCT
admet-1427	86	8	𝑙𝑜𝑔	𝑙𝑜𝑔	NOUN
admet-1427	86	9	(	(	PUNCT
admet-1427	86	10	−𝑟v	−𝑟v	PROPN
admet-1427	86	11	+	+	CCONJ
admet-1427	86	12	(	(	PUNCT
admet-1427	86	13	1+𝑟v	1+𝑟v	NUM
admet-1427	86	14	1−𝑅	1−𝑅	NUM
admet-1427	86	15	)	)	PUNCT
admet-1427	86	16	𝐶d(𝑡	𝐶d(𝑡	ADJ
admet-1427	86	17	)	)	PUNCT
admet-1427	86	18	𝐶d(0	𝐶d(0	NOUN
admet-1427	86	19	)	)	PUNCT
admet-1427	86	20	)	)	PUNCT
admet-1427	87	1	(	(	PUNCT
admet-1427	87	2	1	1	X
admet-1427	87	3	)	)	PUNCT
admet-1427	87	4	𝑅	𝑅	NOUN
admet-1427	87	5	=	=	NOUN
admet-1427	87	6	1	1	NUM
admet-1427	87	7	−	−	NOUN
admet-1427	87	8	𝐶d(𝑡	𝐶d(𝑡	NOUN
admet-1427	87	9	)	)	PUNCT
admet-1427	87	10	𝐶d(0	𝐶d(0	NOUN
admet-1427	87	11	)	)	PUNCT
admet-1427	87	12	−	−	PROPN
admet-1427	87	13	1	1	NUM
admet-1427	87	14	𝑟v	𝑟v	PROPN
admet-1427	87	15	𝐶a(𝑡	𝐶a(𝑡	ADJ
admet-1427	87	16	)	)	PUNCT
admet-1427	87	17	𝐶d(0	𝐶d(0	PROPN
admet-1427	87	18	)	)	PUNCT
admet-1427	87	19	(	(	PUNCT
admet-1427	87	20	2	2	X
admet-1427	87	21	)	)	PUNCT
admet-1427	87	22	𝑟v	𝑟v	NOUN
admet-1427	88	1	=	=	PUNCT
admet-1427	88	2	𝑉d	𝑉d	PROPN
admet-1427	88	3	𝑉a	𝑉a	PROPN
admet-1427	88	4	(	(	PUNCT
admet-1427	88	5	3	3	NUM
admet-1427	88	6	)	)	PUNCT
admet-1427	88	7	where	where	SCONJ
admet-1427	88	8	pe	pe	PROPN
admet-1427	88	9	is	be	AUX
admet-1427	88	10	the	the	DET
admet-1427	88	11	effective	effective	ADJ
admet-1427	88	12	permeation	permeation	NOUN
admet-1427	88	13	coefficient	coefficient	NOUN
admet-1427	88	14	(	(	PUNCT
admet-1427	88	15	cm	cm	NOUN
admet-1427	88	16	/	/	SYM
admet-1427	88	17	s	s	NOUN
admet-1427	88	18	)	)	PUNCT
admet-1427	88	19	,	,	PUNCT
admet-1427	88	20	a	a	PRON
admet-1427	88	21	is	be	AUX
admet-1427	88	22	the	the	DET
admet-1427	88	23	filter	filter	NOUN
admet-1427	88	24	surface	surface	NOUN
admet-1427	88	25	area	area	NOUN
admet-1427	88	26	(	(	PUNCT
admet-1427	88	27	0.266	0.266	NUM
admet-1427	88	28	cm2	cm2	NOUN
admet-1427	88	29	)	)	PUNCT
admet-1427	88	30	,	,	PUNCT
admet-1427	88	31	vd	vd	NOUN
admet-1427	88	32	and	and	CCONJ
admet-1427	88	33	va	va	PROPN
admet-1427	88	34	are	be	AUX
admet-1427	88	35	the	the	DET
admet-1427	88	36	volumes	volume	NOUN
admet-1427	88	37	(	(	PUNCT
admet-1427	88	38	ml	ml	NOUN
admet-1427	88	39	)	)	PUNCT
admet-1427	88	40	of	of	ADP
admet-1427	88	41	the	the	DET
admet-1427	88	42	donor	donor	NOUN
admet-1427	88	43	and	and	CCONJ
admet-1427	88	44	acceptor	acceptor	NOUN
admet-1427	88	45	phases	phase	NOUN
admet-1427	88	46	,	,	PUNCT
admet-1427	88	47	respectively	respectively	ADV
admet-1427	88	48	,	,	PUNCT
admet-1427	88	49	t	t	PROPN
admet-1427	88	50	is	be	AUX
admet-1427	88	51	the	the	DET
admet-1427	88	52	incubation	incubation	NOUN
admet-1427	88	53	time	time	NOUN
admet-1427	88	54	,	,	PUNCT
admet-1427	88	55	cd(t	cd(t	PUNCT
admet-1427	88	56	)	)	PUNCT
admet-1427	88	57	is	be	AUX
admet-1427	88	58	the	the	DET
admet-1427	88	59	concentration	concentration	NOUN
admet-1427	88	60	of	of	ADP
admet-1427	88	61	a	a	DET
admet-1427	88	62	drug	drug	NOUN
admet-1427	88	63	in	in	ADP
admet-1427	88	64	the	the	DET
admet-1427	88	65	donor	donor	NOUN
admet-1427	88	66	phase	phase	NOUN
admet-1427	88	67	at	at	ADP
admet-1427	88	68	time	time	NOUN
admet-1427	88	69	t	t	PROPN
admet-1427	88	70	,	,	PUNCT
admet-1427	88	71	r	r	NOUN
admet-1427	88	72	is	be	AUX
admet-1427	88	73	the	the	DET
admet-1427	88	74	membrane	membrane	NOUN
admet-1427	88	75	retention	retention	NOUN
admet-1427	88	76	factor	factor	NOUN
admet-1427	88	77	,	,	PUNCT
admet-1427	88	78	and	and	CCONJ
admet-1427	88	79	rv	rv	PROPN
admet-1427	88	80	is	be	AUX
admet-1427	88	81	the	the	DET
admet-1427	88	82	volume	volume	NOUN
admet-1427	88	83	ratio	ratio	NOUN
admet-1427	88	84	.	.	PUNCT
admet-1427	89	1	these	these	DET
admet-1427	89	2	equations	equation	NOUN
admet-1427	89	3	are	be	AUX
admet-1427	89	4	generally	generally	ADV
admet-1427	89	5	used	use	VERB
admet-1427	89	6	to	to	PART
admet-1427	89	7	calculate	calculate	VERB
admet-1427	89	8	pe	pe	PROPN
admet-1427	89	9	for	for	ADP
admet-1427	89	10	pampa	pampa	NOUN
admet-1427	89	11	in	in	ADP
admet-1427	89	12	the	the	DET
admet-1427	89	13	literature	literature	NOUN
admet-1427	89	14	.	.	PUNCT
admet-1427	90	1	the	the	DET
admet-1427	90	2	details	detail	NOUN
admet-1427	90	3	for	for	ADP
admet-1427	90	4	the	the	DET
admet-1427	90	5	derivation	derivation	NOUN
admet-1427	90	6	of	of	ADP
admet-1427	90	7	these	these	DET
admet-1427	90	8	equations	equation	NOUN
admet-1427	90	9	have	have	AUX
admet-1427	90	10	been	be	AUX
admet-1427	90	11	reported	report	VERB
admet-1427	90	12	elsewhere	elsewhere	ADV
admet-1427	90	13	[	[	X
admet-1427	90	14	17	17	NUM
admet-1427	90	15	]	]	PUNCT
admet-1427	90	16	.	.	PUNCT
admet-1427	91	1	in	in	ADP
admet-1427	91	2	equations	equation	NOUN
admet-1427	91	3	1	1	NUM
admet-1427	91	4	to	to	PART
admet-1427	91	5	3	3	NUM
admet-1427	91	6	,	,	PUNCT
admet-1427	91	7	the	the	DET
admet-1427	91	8	mass	mass	ADJ
admet-1427	91	9	balance	balance	NOUN
admet-1427	91	10	of	of	ADP
admet-1427	91	11	a	a	DET
admet-1427	91	12	drug	drug	NOUN
admet-1427	91	13	in	in	ADP
admet-1427	91	14	the	the	DET
admet-1427	91	15	donor	donor	NOUN
admet-1427	91	16	fluid	fluid	NOUN
admet-1427	91	17	,	,	PUNCT
admet-1427	91	18	the	the	DET
admet-1427	91	19	acceptor	acceptor	NOUN
admet-1427	91	20	fluid	fluid	NOUN
admet-1427	91	21	,	,	PUNCT
admet-1427	91	22	and	and	CCONJ
admet-1427	91	23	the	the	DET
admet-1427	91	24	membrane	membrane	NOUN
admet-1427	91	25	are	be	AUX
admet-1427	91	26	considered	consider	VERB
admet-1427	91	27	.	.	PUNCT
admet-1427	92	1	the	the	DET
admet-1427	92	2	r	r	NOUN
admet-1427	92	3	values	value	NOUN
admet-1427	92	4	ranged	range	VERB
admet-1427	92	5	from	from	ADP
admet-1427	92	6	<	<	X
admet-1427	92	7	0.1	0.1	NUM
admet-1427	92	8	(	(	PUNCT
admet-1427	92	9	cpfx	cpfx	NOUN
admet-1427	92	10	,	,	PUNCT
admet-1427	92	11	enx	enx	NOUN
admet-1427	92	12	,	,	PUNCT
admet-1427	92	13	nflx	nflx	PROPN
admet-1427	92	14	,	,	PUNCT
admet-1427	92	15	oflx	oflx	ADJ
admet-1427	92	16	,	,	PUNCT
admet-1427	92	17	lvfx	lvfx	NOUN
admet-1427	92	18	)	)	PUNCT
admet-1427	92	19	to	to	ADP
admet-1427	92	20	0.36	0.36	NUM
admet-1427	92	21	(	(	PUNCT
admet-1427	92	22	tflx	tflx	VERB
admet-1427	92	23	)	)	PUNCT
admet-1427	92	24	in	in	ADP
admet-1427	92	25	this	this	DET
admet-1427	92	26	study	study	NOUN
admet-1427	92	27	.	.	PUNCT
admet-1427	93	1	because	because	SCONJ
admet-1427	93	2	it	it	PRON
admet-1427	93	3	is	be	AUX
admet-1427	93	4	difficult	difficult	ADJ
admet-1427	93	5	to	to	PART
admet-1427	93	6	collect	collect	VERB
admet-1427	93	7	samples	sample	NOUN
admet-1427	93	8	multiple	multiple	ADJ
admet-1427	93	9	times	time	NOUN
admet-1427	93	10	from	from	ADP
admet-1427	93	11	a	a	DET
admet-1427	93	12	96	96	NUM
admet-1427	93	13	-	-	PUNCT
admet-1427	93	14	well	well	NOUN
admet-1427	93	15	plate	plate	NOUN
admet-1427	93	16	,	,	PUNCT
admet-1427	93	17	pampa	pampa	PROPN
admet-1427	93	18	pe	pe	PROPN
admet-1427	93	19	is	be	AUX
admet-1427	93	20	usually	usually	ADV
admet-1427	93	21	calculated	calculate	VERB
admet-1427	93	22	from	from	ADP
admet-1427	93	23	one	one	NUM
admet-1427	93	24	-	-	PUNCT
admet-1427	93	25	time	time	NOUN
admet-1427	93	26	point	point	NOUN
admet-1427	93	27	data	datum	NOUN
admet-1427	93	28	.	.	PUNCT
admet-1427	94	1	in	in	ADP
admet-1427	94	2	typical	typical	ADJ
admet-1427	94	3	pampa	pampa	NOUN
admet-1427	94	4	experiments	experiment	NOUN
admet-1427	94	5	,	,	PUNCT
admet-1427	94	6	the	the	DET
admet-1427	94	7	steady	steady	ADJ
admet-1427	94	8	state	state	NOUN
admet-1427	94	9	is	be	AUX
admet-1427	94	10	achieved	achieve	VERB
admet-1427	94	11	within	within	ADP
admet-1427	94	12	0	0	NUM
admet-1427	94	13	to	to	ADP
admet-1427	94	14	45	45	NUM
admet-1427	94	15	min	min	NOUN
admet-1427	95	1	[	[	X
admet-1427	95	2	17	17	NUM
admet-1427	95	3	]	]	PUNCT
admet-1427	95	4	.	.	PUNCT
admet-1427	96	1	therefore	therefore	ADV
admet-1427	96	2	,	,	PUNCT
admet-1427	96	3	pampa	pampa	PROPN
admet-1427	96	4	pe	pe	PROPN
admet-1427	96	5	is	be	AUX
admet-1427	96	6	usually	usually	ADV
admet-1427	96	7	calculated	calculate	VERB
admet-1427	96	8	from	from	ADP
admet-1427	96	9	one	one	NUM
admet-1427	96	10	-	-	PUNCT
admet-1427	96	11	time	time	NOUN
admet-1427	96	12	point	point	NOUN
admet-1427	96	13	data	datum	NOUN
admet-1427	96	14	at	at	ADP
admet-1427	96	15	>	>	X
admet-1427	96	16	2	2	NUM
admet-1427	96	17	h	h	NOUN
admet-1427	97	1	[	[	X
admet-1427	97	2	6–9	6–9	NOUN
admet-1427	97	3	]	]	PUNCT
admet-1427	97	4	.	.	PUNCT
admet-1427	98	1	log	log	PROPN
admet-1427	98	2	d	d	NOUN
admet-1427	98	3	measurement	measurement	NOUN
admet-1427	98	4	of	of	ADP
admet-1427	98	5	the	the	DET
admet-1427	98	6	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	98	7	the	the	DET
admet-1427	98	8	octanol	octanol	NOUN
admet-1427	98	9	-	-	PUNCT
admet-1427	98	10	buffer	buffer	NOUN
admet-1427	98	11	distribution	distribution	NOUN
admet-1427	98	12	coefficient	coefficient	NOUN
admet-1427	98	13	(	(	PUNCT
admet-1427	98	14	log	log	NOUN
admet-1427	98	15	d	d	NOUN
admet-1427	98	16	)	)	PUNCT
admet-1427	98	17	was	be	AUX
admet-1427	98	18	determined	determine	VERB
admet-1427	98	19	at	at	ADP
admet-1427	98	20	ph	ph	PROPN
admet-1427	98	21	6.5	6.5	NUM
admet-1427	98	22	by	by	ADP
admet-1427	98	23	a	a	DET
admet-1427	98	24	shake	shake	NOUN
admet-1427	98	25	-	-	PUNCT
admet-1427	98	26	flask	flask	NOUN
admet-1427	98	27	method	method	NOUN
admet-1427	98	28	.	.	PUNCT
admet-1427	99	1	the	the	DET
admet-1427	99	2	octanol	octanol	NOUN
admet-1427	99	3	and	and	CCONJ
admet-1427	99	4	buffer	buffer	VERB
admet-1427	99	5	phases	phase	NOUN
admet-1427	99	6	were	be	AUX
admet-1427	99	7	mutually	mutually	ADV
admet-1427	99	8	pre	pre	ADJ
admet-1427	99	9	-	-	VERB
admet-1427	99	10	saturated	saturated	ADJ
admet-1427	99	11	before	before	ADP
admet-1427	99	12	use	use	NOUN
admet-1427	99	13	.	.	PUNCT
admet-1427	100	1	a	a	DET
admet-1427	100	2	buffer	buffer	NOUN
admet-1427	100	3	solution	solution	NOUN
admet-1427	100	4	of	of	ADP
admet-1427	100	5	a	a	DET
admet-1427	100	6	model	model	NOUN
admet-1427	100	7	drug	drug	NOUN
admet-1427	100	8	(	(	PUNCT
admet-1427	100	9	1.0	1.0	NUM
admet-1427	100	10	mm	mm	NOUN
admet-1427	100	11	,	,	PUNCT
admet-1427	100	12	0.5	0.5	NUM
admet-1427	100	13	ml	ml	NOUN
admet-1427	100	14	,	,	PUNCT
admet-1427	100	15	50	50	NUM
admet-1427	100	16	mm	mm	NOUN
admet-1427	100	17	sodium	sodium	NOUN
admet-1427	100	18	–	–	PUNCT
admet-1427	100	19	phosphate	phosphate	NOUN
admet-1427	100	20	buffer	buffer	NOUN
admet-1427	100	21	)	)	PUNCT
admet-1427	100	22	and	and	CCONJ
admet-1427	100	23	octanol	octanol	NOUN
admet-1427	100	24	(	(	PUNCT
admet-1427	100	25	2.5	2.5	NUM
admet-1427	100	26	ml	ml	NOUN
admet-1427	100	27	)	)	PUNCT
admet-1427	100	28	was	be	AUX
admet-1427	100	29	added	add	VERB
admet-1427	100	30	to	to	ADP
admet-1427	100	31	a	a	DET
admet-1427	100	32	15	15	NUM
admet-1427	100	33	ml	ml	NOUN
admet-1427	100	34	tube	tube	NOUN
admet-1427	100	35	.	.	PUNCT
admet-1427	101	1	the	the	DET
admet-1427	101	2	sample	sample	NOUN
admet-1427	101	3	was	be	AUX
admet-1427	101	4	vigorously	vigorously	ADV
admet-1427	101	5	shaken	shake	VERB
admet-1427	101	6	for	for	ADP
admet-1427	101	7	90	90	NUM
admet-1427	101	8	min	min	NOUN
admet-1427	101	9	at	at	ADP
admet-1427	101	10	25	25	NUM
admet-1427	101	11	°	°	NOUN
admet-1427	101	12	c	c	NOUN
admet-1427	101	13	.	.	PUNCT
admet-1427	102	1	because	because	SCONJ
admet-1427	102	2	log	log	PROPN
admet-1427	102	3	d	d	NOUN
admet-1427	102	4	is	be	AUX
admet-1427	102	5	a	a	DET
admet-1427	102	6	physicochemical	physicochemical	ADJ
admet-1427	102	7	property	property	NOUN
admet-1427	102	8	of	of	ADP
admet-1427	102	9	a	a	DET
admet-1427	102	10	drug	drug	NOUN
admet-1427	102	11	,	,	PUNCT
admet-1427	102	12	it	it	PRON
admet-1427	102	13	was	be	AUX
admet-1427	102	14	measured	measure	VERB
admet-1427	102	15	at	at	ADP
admet-1427	102	16	a	a	DET
admet-1427	102	17	standard	standard	ADJ
admet-1427	102	18	condition	condition	NOUN
admet-1427	102	19	of	of	ADP
admet-1427	102	20	25	25	NUM
admet-1427	102	21	°	°	NOUN
admet-1427	102	22	c	c	NOUN
admet-1427	102	23	,	,	PUNCT
admet-1427	102	24	rather	rather	ADV
admet-1427	102	25	than	than	ADP
admet-1427	102	26	37	37	NUM
admet-1427	102	27	°	°	NOUN
admet-1427	102	28	c	c	NOUN
admet-1427	102	29	.	.	PUNCT
admet-1427	103	1	the	the	DET
admet-1427	103	2	concentration	concentration	NOUN
admet-1427	103	3	of	of	ADP
admet-1427	103	4	fqs	fqs	NOUN
admet-1427	103	5	in	in	ADP
admet-1427	103	6	the	the	DET
admet-1427	103	7	aqueous	aqueous	ADJ
admet-1427	103	8	phase	phase	NOUN
admet-1427	103	9	was	be	AUX
admet-1427	103	10	determined	determine	VERB
admet-1427	103	11	as	as	ADP
admet-1427	103	12	described	describe	VERB
admet-1427	103	13	above	above	ADV
admet-1427	103	14	.	.	PUNCT
admet-1427	104	1	log	log	PROPN
admet-1427	104	2	d	d	PROPN
admet-1427	104	3	was	be	AUX
admet-1427	104	4	measured	measure	VERB
admet-1427	104	5	in	in	ADP
admet-1427	104	6	triplicate	triplicate	PROPN
admet-1427	104	7	.	.	PUNCT
admet-1427	105	1	results	result	NOUN
admet-1427	105	2	effect	effect	NOUN
admet-1427	105	3	of	of	ADP
admet-1427	105	4	physicochemical	physicochemical	ADJ
admet-1427	105	5	properties	property	NOUN
admet-1427	105	6	of	of	ADP
admet-1427	105	7	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	105	8	on	on	ADP
admet-1427	105	9	pampa	pampa	NOUN
admet-1427	105	10	permeability	permeability	NOUN
admet-1427	105	11	all	all	DET
admet-1427	105	12	pampa	pampa	NOUN
admet-1427	105	13	permeability	permeability	NOUN
admet-1427	105	14	data	datum	NOUN
admet-1427	105	15	are	be	AUX
admet-1427	105	16	summarized	summarize	VERB
admet-1427	105	17	in	in	ADP
admet-1427	105	18	the	the	DET
admet-1427	105	19	supplemental	supplemental	ADJ
admet-1427	105	20	material	material	NOUN
admet-1427	105	21	(	(	PUNCT
admet-1427	105	22	table	table	NOUN
admet-1427	105	23	s1	s1	NOUN
admet-1427	105	24	)	)	PUNCT
admet-1427	105	25	.	.	PUNCT
admet-1427	106	1	the	the	DET
admet-1427	106	2	effect	effect	NOUN
admet-1427	106	3	of	of	ADP
admet-1427	106	4	the	the	DET
admet-1427	106	5	physicochemical	physicochemical	ADJ
admet-1427	106	6	properties	property	NOUN
admet-1427	106	7	of	of	ADP
admet-1427	106	8	fqs	fqs	NOUN
admet-1427	106	9	on	on	ADP
admet-1427	106	10	pampa	pampa	PROPN
admet-1427	106	11	pe	pe	PROPN
admet-1427	106	12	was	be	AUX
admet-1427	106	13	first	first	ADV
admet-1427	106	14	investigated	investigate	VERB
admet-1427	106	15	(	(	PUNCT
admet-1427	106	16	figure	figure	NOUN
admet-1427	106	17	2	2	NUM
admet-1427	106	18	)	)	PUNCT
admet-1427	106	19	.	.	PUNCT
admet-1427	107	1	the	the	DET
admet-1427	107	2	pe	pe	PROPN
admet-1427	107	3	value	value	NOUN
admet-1427	107	4	tended	tend	VERB
admet-1427	107	5	to	to	PART
admet-1427	107	6	increase	increase	VERB
admet-1427	107	7	as	as	SCONJ
admet-1427	107	8	log	log	NOUN
admet-1427	107	9	d	d	NOUN
admet-1427	107	10	increased	increase	VERB
admet-1427	107	11	.	.	PUNCT
admet-1427	108	1	above	above	ADP
admet-1427	108	2	log	log	VERB
admet-1427	108	3	d	d	X
admet-1427	108	4	>	>	X
admet-1427	108	5	0	0	PROPN
admet-1427	108	6	,	,	PUNCT
admet-1427	108	7	the	the	DET
admet-1427	108	8	pe	pe	PROPN
admet-1427	108	9	value	value	NOUN
admet-1427	108	10	reached	reach	VERB
admet-1427	108	11	a	a	DET
admet-1427	108	12	plateau	plateau	NOUN
admet-1427	108	13	value	value	NOUN
admet-1427	108	14	of	of	ADP
admet-1427	108	15	about	about	ADV
admet-1427	108	16	30	30	NUM
admet-1427	108	17	×	×	NOUN
admet-1427	108	18	10	10	NUM
admet-1427	108	19	-	-	SYM
admet-1427	108	20	6	6	NUM
admet-1427	108	21	cm	cm	NOUN
admet-1427	108	22	/	/	SYM
admet-1427	108	23	s.	s.	PROPN
admet-1427	108	24	there	there	PRON
admet-1427	108	25	was	be	VERB
admet-1427	108	26	no	no	DET
admet-1427	108	27	correlation	correlation	NOUN
admet-1427	108	28	between	between	ADP
admet-1427	108	29	pe	pe	PROPN
admet-1427	108	30	and	and	CCONJ
admet-1427	108	31	the	the	DET
admet-1427	108	32	pka	pka	PROPN
admet-1427	108	33	values	value	NOUN
admet-1427	108	34	.	.	PUNCT
admet-1427	109	1	figure	figure	NOUN
admet-1427	109	2	2	2	NUM
admet-1427	109	3	.	.	PUNCT
admet-1427	109	4	correlation	correlation	NOUN
admet-1427	109	5	between	between	ADP
admet-1427	109	6	pampa	pampa	NOUN
admet-1427	109	7	permeability	permeability	NOUN
admet-1427	109	8	,	,	PUNCT
admet-1427	109	9	log	log	VERB
admet-1427	109	10	d	d	NOUN
admet-1427	109	11	,	,	PUNCT
admet-1427	109	12	and	and	CCONJ
admet-1427	109	13	mw	mw	PROPN
admet-1427	109	14	admet	admet	PROPN
admet-1427	109	15	&	&	CCONJ
admet-1427	109	16	dmpk	dmpk	PROPN
admet-1427	109	17	10(4	10(4	NUM
admet-1427	109	18	)	)	PUNCT
admet-1427	109	19	(	(	PUNCT
admet-1427	109	20	2022	2022	NUM
admet-1427	109	21	)	)	PUNCT
admet-1427	109	22	289	289	NUM
admet-1427	109	23	-	-	PUNCT
admet-1427	109	24	297	297	NUM
admet-1427	109	25	artificial	artificial	ADJ
admet-1427	109	26	membrane	membrane	NOUN
admet-1427	109	27	permeation	permeation	NOUN
admet-1427	109	28	of	of	ADP
admet-1427	109	29	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	109	30	doi	doi	NOUN
admet-1427	109	31	:	:	PUNCT
admet-1427	109	32	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	X
admet-1427	109	33	293	293	NUM
admet-1427	109	34	in	in	ADP
admet-1427	109	35	vitro	vitro	X
admet-1427	109	36	–	–	PUNCT
admet-1427	109	37	in	in	ADP
admet-1427	109	38	vivo	vivo	ADJ
admet-1427	109	39	correlation	correlation	NOUN
admet-1427	109	40	of	of	ADP
admet-1427	109	41	fq	fq	PROPN
admet-1427	109	42	–	–	PUNCT
admet-1427	109	43	metal	metal	NOUN
admet-1427	109	44	ion	ion	NOUN
admet-1427	109	45	interaction	interaction	NOUN
admet-1427	109	46	since	since	SCONJ
admet-1427	109	47	metal	metal	NOUN
admet-1427	109	48	ions	ion	NOUN
admet-1427	109	49	can	can	AUX
admet-1427	109	50	interact	interact	VERB
admet-1427	109	51	with	with	ADP
admet-1427	109	52	phosphate	phosphate	ADJ
admet-1427	109	53	and	and	CCONJ
admet-1427	109	54	citrate	citrate	NOUN
admet-1427	109	55	ions	ion	NOUN
admet-1427	109	56	,	,	PUNCT
admet-1427	109	57	mes	me	NOUN
admet-1427	109	58	buffer	buffer	NOUN
admet-1427	109	59	was	be	AUX
admet-1427	109	60	used	use	VERB
admet-1427	109	61	in	in	ADP
admet-1427	109	62	this	this	DET
admet-1427	109	63	study	study	NOUN
admet-1427	109	64	.	.	PUNCT
admet-1427	110	1	the	the	DET
admet-1427	110	2	concentration	concentration	NOUN
admet-1427	110	3	of	of	ADP
admet-1427	110	4	metal	metal	NOUN
admet-1427	110	5	ions	ion	NOUN
admet-1427	110	6	was	be	AUX
admet-1427	110	7	set	set	VERB
admet-1427	110	8	to	to	PART
admet-1427	110	9	reflect	reflect	VERB
admet-1427	110	10	the	the	DET
admet-1427	110	11	clinical	clinical	ADJ
admet-1427	110	12	dose	dose	NOUN
admet-1427	110	13	and	and	CCONJ
admet-1427	110	14	the	the	DET
admet-1427	110	15	gastrointestinal	gastrointestinal	ADJ
admet-1427	110	16	fluid	fluid	NOUN
admet-1427	110	17	volume	volume	NOUN
admet-1427	110	18	.	.	PUNCT
admet-1427	111	1	in	in	ADP
admet-1427	111	2	the	the	DET
admet-1427	111	3	presence	presence	NOUN
admet-1427	111	4	of	of	ADP
admet-1427	111	5	metal	metal	NOUN
admet-1427	111	6	ions	ion	NOUN
admet-1427	111	7	,	,	PUNCT
admet-1427	111	8	the	the	DET
admet-1427	111	9	pe	pe	PROPN
admet-1427	111	10	values	value	NOUN
admet-1427	111	11	were	be	AUX
admet-1427	111	12	reduced	reduce	VERB
admet-1427	111	13	in	in	ADP
admet-1427	111	14	all	all	DET
admet-1427	111	15	fqs	fqs	NOUN
admet-1427	111	16	(	(	PUNCT
admet-1427	111	17	supplemental	supplemental	ADJ
admet-1427	111	18	material	material	NOUN
admet-1427	111	19	table	table	NOUN
admet-1427	111	20	s1	s1	NOUN
admet-1427	111	21	)	)	PUNCT
admet-1427	111	22	.	.	PUNCT
admet-1427	112	1	trivalent	trivalent	NOUN
admet-1427	112	2	ions	ion	NOUN
admet-1427	112	3	(	(	PUNCT
admet-1427	112	4	al3	al3	PROPN
admet-1427	112	5	+	+	PROPN
admet-1427	112	6	,	,	PUNCT
admet-1427	112	7	fe3	fe3	NOUN
admet-1427	112	8	+	+	PROPN
admet-1427	112	9	,	,	PUNCT
admet-1427	112	10	and	and	CCONJ
admet-1427	112	11	la3	la3	NOUN
admet-1427	112	12	+	+	CCONJ
admet-1427	112	13	)	)	PUNCT
admet-1427	112	14	tended	tend	VERB
admet-1427	112	15	to	to	PART
admet-1427	112	16	show	show	VERB
admet-1427	112	17	a	a	DET
admet-1427	112	18	stronger	strong	ADJ
admet-1427	112	19	inhibition	inhibition	NOUN
admet-1427	112	20	effect	effect	NOUN
admet-1427	112	21	than	than	ADP
admet-1427	112	22	divalent	divalent	ADJ
admet-1427	112	23	ions	ion	NOUN
admet-1427	112	24	.	.	PUNCT
admet-1427	113	1	the	the	DET
admet-1427	113	2	correlations	correlation	NOUN
admet-1427	113	3	between	between	ADP
admet-1427	113	4	the	the	DET
admet-1427	113	5	urinary	urinary	ADJ
admet-1427	113	6	excretion	excretion	NOUN
admet-1427	113	7	(	(	PUNCT
admet-1427	113	8	ur	ur	INTJ
admet-1427	113	9	)	)	PUNCT
admet-1427	113	10	and	and	CCONJ
admet-1427	113	11	auc	auc	VERB
admet-1427	113	12	ratios	ratio	NOUN
admet-1427	113	13	in	in	ADP
admet-1427	113	14	humans	human	NOUN
admet-1427	113	15	and	and	CCONJ
admet-1427	113	16	the	the	DET
admet-1427	113	17	pampa	pampa	PROPN
admet-1427	113	18	pe	pe	PROPN
admet-1427	113	19	ratio	ratio	NOUN
admet-1427	113	20	are	be	AUX
admet-1427	113	21	shown	show	VERB
admet-1427	113	22	in	in	ADP
admet-1427	113	23	figure	figure	NOUN
admet-1427	113	24	3	3	NUM
admet-1427	113	25	(	(	PUNCT
admet-1427	113	26	categorized	categorize	VERB
admet-1427	113	27	by	by	ADP
admet-1427	113	28	metal	metal	NOUN
admet-1427	113	29	ions	ion	NOUN
admet-1427	113	30	)	)	PUNCT
admet-1427	113	31	and	and	CCONJ
admet-1427	113	32	also	also	ADV
admet-1427	113	33	in	in	ADP
admet-1427	113	34	supplemental	supplemental	ADJ
admet-1427	113	35	material	material	NOUN
admet-1427	113	36	figure	figure	NOUN
admet-1427	113	37	s1	s1	NOUN
admet-1427	113	38	(	(	PUNCT
admet-1427	113	39	categorized	categorize	VERB
admet-1427	113	40	by	by	ADP
admet-1427	113	41	fq	fq	PROPN
admet-1427	113	42	)	)	PUNCT
admet-1427	113	43	.	.	PUNCT
admet-1427	114	1	clinical	clinical	ADJ
admet-1427	114	2	and	and	CCONJ
admet-1427	114	3	in	in	ADP
admet-1427	114	4	vivo	vivo	NOUN
admet-1427	114	5	canine	canine	NOUN
admet-1427	114	6	data	datum	NOUN
admet-1427	114	7	are	be	AUX
admet-1427	114	8	summarized	summarize	VERB
admet-1427	114	9	in	in	ADP
admet-1427	114	10	supplemental	supplemental	ADJ
admet-1427	114	11	material	material	NOUN
admet-1427	114	12	table	table	NOUN
admet-1427	114	13	s2	s2	NOUN
admet-1427	114	14	with	with	ADP
admet-1427	114	15	the	the	DET
admet-1427	114	16	references	reference	NOUN
admet-1427	114	17	.	.	PUNCT
admet-1427	115	1	there	there	PRON
admet-1427	115	2	is	be	VERB
admet-1427	115	3	a	a	DET
admet-1427	115	4	general	general	ADJ
admet-1427	115	5	trend	trend	NOUN
admet-1427	115	6	that	that	SCONJ
admet-1427	115	7	as	as	SCONJ
admet-1427	115	8	the	the	DET
admet-1427	115	9	pe	pe	PROPN
admet-1427	115	10	ratio	ratio	NOUN
admet-1427	115	11	(	(	PUNCT
admet-1427	115	12	with	with	ADP
admet-1427	115	13	/	/	SYM
admet-1427	115	14	without	without	ADP
admet-1427	115	15	metal	metal	NOUN
admet-1427	115	16	ions	ion	NOUN
admet-1427	115	17	)	)	PUNCT
admet-1427	115	18	becomes	become	VERB
admet-1427	115	19	smaller	small	ADJ
admet-1427	115	20	,	,	PUNCT
admet-1427	115	21	the	the	DET
admet-1427	115	22	reduction	reduction	NOUN
admet-1427	115	23	in	in	ADP
admet-1427	115	24	auc	auc	NOUN
admet-1427	115	25	and	and	CCONJ
admet-1427	115	26	ur	ur	INTJ
admet-1427	115	27	becomes	become	VERB
admet-1427	115	28	more	more	ADV
admet-1427	115	29	significant	significant	ADJ
admet-1427	115	30	.	.	PUNCT
admet-1427	116	1	however	however	ADV
admet-1427	116	2	,	,	PUNCT
admet-1427	116	3	pampa	pampa	PROPN
admet-1427	116	4	tended	tend	VERB
admet-1427	116	5	to	to	PART
admet-1427	116	6	overpredict	overpredict	VERB
admet-1427	116	7	the	the	DET
admet-1427	116	8	reduction	reduction	NOUN
admet-1427	116	9	in	in	ADP
admet-1427	116	10	auc	auc	NOUN
admet-1427	116	11	and	and	CCONJ
admet-1427	116	12	ur	ur	INTJ
admet-1427	116	13	,	,	PUNCT
admet-1427	116	14	especially	especially	ADV
admet-1427	116	15	for	for	ADP
admet-1427	116	16	al3	al3	PROPN
admet-1427	116	17	+	+	CCONJ
admet-1427	116	18	and	and	CCONJ
admet-1427	116	19	la3	la3	NOUN
admet-1427	116	20	+	+	CCONJ
admet-1427	116	21	with	with	ADP
admet-1427	116	22	high	high	ADJ
admet-1427	116	23	permeability	permeability	NOUN
admet-1427	116	24	fqs	fqs	NOUN
admet-1427	116	25	(	(	PUNCT
admet-1427	116	26	pe	pe	INTJ
admet-1427	116	27	>	>	X
admet-1427	116	28	10	10	NUM
admet-1427	116	29	-	-	SYM
admet-1427	116	30	5	5	NUM
admet-1427	116	31	cm	cm	NOUN
admet-1427	116	32	/	/	SYM
admet-1427	116	33	s	s	NOUN
admet-1427	116	34	)	)	PUNCT
admet-1427	116	35	.	.	PUNCT
admet-1427	117	1	figure	figure	VERB
admet-1427	117	2	3	3	NUM
admet-1427	117	3	.	.	PUNCT
admet-1427	117	4	correlation	correlation	NOUN
admet-1427	117	5	between	between	ADP
admet-1427	117	6	pampa	pampa	PROPN
admet-1427	117	7	pe	pe	VERB
admet-1427	117	8	ratio	ratio	NOUN
admet-1427	117	9	with	with	ADP
admet-1427	117	10	/	/	SYM
admet-1427	117	11	without	without	ADP
admet-1427	117	12	metal	metal	NOUN
admet-1427	117	13	ions	ion	NOUN
admet-1427	117	14	and	and	CCONJ
admet-1427	117	15	(	(	PUNCT
admet-1427	117	16	a	a	X
admet-1427	117	17	)	)	PUNCT
admet-1427	117	18	urinary	urinary	ADJ
admet-1427	117	19	excretion	excretion	NOUN
admet-1427	117	20	ratio	ratio	NOUN
admet-1427	117	21	and	and	CCONJ
admet-1427	117	22	(	(	PUNCT
admet-1427	117	23	b	b	NOUN
admet-1427	117	24	)	)	PUNCT
admet-1427	117	25	auc	auc	NOUN
admet-1427	117	26	ratio	ratio	NOUN
admet-1427	117	27	in	in	ADP
admet-1427	117	28	humans	human	NOUN
admet-1427	117	29	(	(	PUNCT
admet-1427	117	30	annotated	annotate	VERB
admet-1427	117	31	by	by	ADP
admet-1427	117	32	metal	metal	NOUN
admet-1427	117	33	ions	ion	NOUN
admet-1427	117	34	)	)	PUNCT
admet-1427	117	35	.	.	PUNCT
admet-1427	118	1	the	the	DET
admet-1427	118	2	interactions	interaction	NOUN
admet-1427	118	3	between	between	ADP
admet-1427	118	4	norfloxacin	norfloxacin	PROPN
admet-1427	118	5	(	(	PUNCT
admet-1427	118	6	nflx	nflx	PROPN
admet-1427	118	7	)	)	PUNCT
admet-1427	118	8	and	and	CCONJ
admet-1427	118	9	various	various	ADJ
admet-1427	118	10	metal	metal	NOUN
admet-1427	118	11	ions	ion	NOUN
admet-1427	118	12	have	have	AUX
admet-1427	118	13	been	be	AUX
admet-1427	118	14	investigated	investigate	VERB
admet-1427	118	15	in	in	ADP
admet-1427	118	16	dogs	dog	NOUN
admet-1427	118	17	[	[	X
admet-1427	118	18	18	18	NUM
admet-1427	118	19	]	]	PUNCT
admet-1427	118	20	.	.	PUNCT
admet-1427	119	1	there	there	PRON
admet-1427	119	2	is	be	VERB
admet-1427	119	3	a	a	DET
admet-1427	119	4	good	good	ADJ
admet-1427	119	5	correlation	correlation	NOUN
admet-1427	119	6	between	between	ADP
admet-1427	119	7	the	the	DET
admet-1427	119	8	pampa	pampa	PROPN
admet-1427	119	9	pe	pe	NOUN
admet-1427	119	10	ratio	ratio	NOUN
admet-1427	119	11	and	and	CCONJ
admet-1427	119	12	the	the	PRON
admet-1427	119	13	in	in	ADP
admet-1427	119	14	vivo	vivo	ADJ
admet-1427	119	15	cmax	cmax	NOUN
admet-1427	119	16	and	and	CCONJ
admet-1427	119	17	auc	auc	NOUN
admet-1427	119	18	ratios	ratio	NOUN
admet-1427	119	19	(	(	PUNCT
admet-1427	119	20	figure	figure	NOUN
admet-1427	119	21	4	4	NUM
admet-1427	119	22	)	)	PUNCT
admet-1427	119	23	.	.	PUNCT
admet-1427	120	1	figure	figure	VERB
admet-1427	120	2	4	4	NUM
admet-1427	120	3	.	.	PUNCT
admet-1427	120	4	correlation	correlation	NOUN
admet-1427	120	5	between	between	ADP
admet-1427	120	6	the	the	DET
admet-1427	120	7	pampa	pampa	PROPN
admet-1427	120	8	pe	pe	NOUN
admet-1427	120	9	ratio	ratio	NOUN
admet-1427	120	10	and	and	CCONJ
admet-1427	120	11	(	(	PUNCT
admet-1427	120	12	a	a	X
admet-1427	120	13	)	)	PUNCT
admet-1427	120	14	cmax	cmax	NOUN
admet-1427	120	15	and	and	CCONJ
admet-1427	120	16	(	(	PUNCT
admet-1427	120	17	b	b	NOUN
admet-1427	120	18	)	)	PUNCT
admet-1427	120	19	auc	auc	NOUN
admet-1427	120	20	ratios	ratio	NOUN
admet-1427	120	21	in	in	ADP
admet-1427	120	22	dogs	dog	NOUN
admet-1427	120	23	.	.	PUNCT
admet-1427	121	1	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	NOUN
admet-1427	121	2	nakatani	nakatani	ADJ
admet-1427	121	3	and	and	CCONJ
admet-1427	121	4	sugano	sugano	ADJ
admet-1427	121	5	admet	admet	PROPN
admet-1427	121	6	&	&	CCONJ
admet-1427	121	7	dmpk	dmpk	PROPN
admet-1427	121	8	10(4	10(4	NUM
admet-1427	121	9	)	)	PUNCT
admet-1427	121	10	(	(	PUNCT
admet-1427	121	11	2022	2022	NUM
admet-1427	121	12	)	)	PUNCT
admet-1427	121	13	289	289	NUM
admet-1427	121	14	-	-	SYM
admet-1427	121	15	297	297	NUM
admet-1427	121	16	294	294	NUM
admet-1427	121	17	discussion	discussion	NOUN
admet-1427	121	18	at	at	ADP
admet-1427	121	19	ph	ph	PROPN
admet-1427	121	20	6.5	6.5	NUM
admet-1427	121	21	,	,	PUNCT
admet-1427	121	22	fq	fq	PROPN
admet-1427	121	23	molecules	molecule	NOUN
admet-1427	121	24	exist	exist	VERB
admet-1427	121	25	as	as	ADP
admet-1427	121	26	a	a	DET
admet-1427	121	27	zwitterion	zwitterion	NOUN
admet-1427	121	28	(	(	PUNCT
admet-1427	121	29	table	table	NOUN
admet-1427	121	30	1	1	NUM
admet-1427	121	31	)	)	PUNCT
admet-1427	121	32	.	.	PUNCT
admet-1427	122	1	according	accord	VERB
admet-1427	122	2	to	to	ADP
admet-1427	122	3	the	the	DET
admet-1427	122	4	ph	ph	ADJ
admet-1427	122	5	-	-	PUNCT
admet-1427	122	6	partition	partition	NOUN
admet-1427	122	7	hypothesis	hypothesis	NOUN
admet-1427	122	8	,	,	PUNCT
admet-1427	122	9	zwitterionic	zwitterionic	ADJ
admet-1427	122	10	drugs	drug	NOUN
admet-1427	122	11	are	be	AUX
admet-1427	122	12	often	often	ADV
admet-1427	122	13	assumed	assume	VERB
admet-1427	122	14	to	to	PART
admet-1427	122	15	show	show	VERB
admet-1427	122	16	poor	poor	ADJ
admet-1427	122	17	membrane	membrane	NOUN
admet-1427	122	18	permeability	permeability	NOUN
admet-1427	122	19	[	[	X
admet-1427	122	20	19	19	NUM
admet-1427	122	21	]	]	PUNCT
admet-1427	122	22	.	.	PUNCT
admet-1427	123	1	however	however	ADV
admet-1427	123	2	,	,	PUNCT
admet-1427	123	3	we	we	PRON
admet-1427	123	4	previously	previously	ADV
admet-1427	123	5	reported	report	VERB
admet-1427	123	6	that	that	SCONJ
admet-1427	123	7	zwitterionic	zwitterionic	ADJ
admet-1427	123	8	tetracyclines	tetracycline	NOUN
admet-1427	123	9	can	can	AUX
admet-1427	123	10	permeate	permeate	VERB
admet-1427	123	11	the	the	DET
admet-1427	123	12	pampa	pampa	NOUN
admet-1427	123	13	membrane	membrane	NOUN
admet-1427	123	14	in	in	ADP
admet-1427	123	15	the	the	DET
admet-1427	123	16	presence	presence	NOUN
admet-1427	123	17	of	of	ADP
admet-1427	123	18	phospholipids	phospholipid	NOUN
admet-1427	123	19	(	(	PUNCT
admet-1427	123	20	soybean	soybean	NOUN
admet-1427	123	21	lecithin	lecithin	NOUN
admet-1427	123	22	)	)	PUNCT
admet-1427	123	23	(	(	PUNCT
admet-1427	123	24	sl	sl	NOUN
admet-1427	123	25	-	-	PUNCT
admet-1427	123	26	pampa	pampa	NOUN
admet-1427	123	27	)	)	PUNCT
admet-1427	123	28	,	,	PUNCT
admet-1427	123	29	despite	despite	SCONJ
admet-1427	123	30	their	their	PRON
admet-1427	123	31	hydrophilic	hydrophilic	ADJ
admet-1427	123	32	and	and	CCONJ
admet-1427	123	33	zwitterionic	zwitterionic	ADJ
admet-1427	123	34	properties	property	NOUN
admet-1427	123	35	[	[	X
admet-1427	123	36	11	11	NUM
admet-1427	123	37	]	]	PUNCT
admet-1427	123	38	.	.	PUNCT
admet-1427	124	1	in	in	ADP
admet-1427	124	2	addition	addition	NOUN
admet-1427	124	3	,	,	PUNCT
admet-1427	124	4	sl	sl	NOUN
admet-1427	124	5	-	-	PUNCT
admet-1427	124	6	pampa	pampa	NOUN
admet-1427	124	7	has	have	AUX
admet-1427	124	8	been	be	AUX
admet-1427	124	9	used	use	VERB
admet-1427	124	10	to	to	PART
admet-1427	124	11	investigate	investigate	VERB
admet-1427	124	12	the	the	DET
admet-1427	124	13	effect	effect	NOUN
admet-1427	124	14	of	of	ADP
admet-1427	124	15	metal	metal	NOUN
admet-1427	124	16	ions	ion	NOUN
admet-1427	124	17	on	on	ADP
admet-1427	124	18	the	the	DET
admet-1427	124	19	permeation	permeation	NOUN
admet-1427	124	20	of	of	ADP
admet-1427	124	21	tetracyclines	tetracycline	NOUN
admet-1427	124	22	[	[	X
admet-1427	124	23	10	10	NUM
admet-1427	124	24	]	]	PUNCT
admet-1427	124	25	.	.	PUNCT
admet-1427	125	1	therefore	therefore	ADV
admet-1427	125	2	,	,	PUNCT
admet-1427	125	3	sl	sl	X
admet-1427	125	4	-	-	PUNCT
admet-1427	125	5	pampa	pampa	NOUN
admet-1427	125	6	was	be	AUX
admet-1427	125	7	used	use	VERB
admet-1427	125	8	in	in	ADP
admet-1427	125	9	this	this	DET
admet-1427	125	10	study	study	NOUN
admet-1427	125	11	.	.	PUNCT
admet-1427	126	1	in	in	ADP
admet-1427	126	2	the	the	DET
admet-1427	126	3	absence	absence	NOUN
admet-1427	126	4	of	of	ADP
admet-1427	126	5	metal	metal	NOUN
admet-1427	126	6	ions	ion	NOUN
admet-1427	126	7	,	,	PUNCT
admet-1427	126	8	fqs	fqs	PROPN
admet-1427	126	9	showed	show	VERB
admet-1427	126	10	relatively	relatively	ADV
admet-1427	126	11	high	high	ADJ
admet-1427	126	12	permeability	permeability	NOUN
admet-1427	126	13	(	(	PUNCT
admet-1427	126	14	>	>	X
admet-1427	126	15	5	5	NUM
admet-1427	126	16	×	×	NOUN
admet-1427	126	17	10	10	NUM
admet-1427	126	18	-	-	SYM
admet-1427	126	19	6	6	NUM
admet-1427	126	20	cm	cm	NOUN
admet-1427	126	21	/	/	SYM
admet-1427	126	22	sec	sec	PROPN
admet-1427	126	23	)	)	PUNCT
admet-1427	126	24	in	in	ADP
admet-1427	126	25	sl	sl	NOUN
admet-1427	126	26	-	-	PUNCT
admet-1427	126	27	pampa	pampa	NOUN
admet-1427	126	28	despite	despite	SCONJ
admet-1427	126	29	their	their	PRON
admet-1427	126	30	hydrophilic	hydrophilic	ADJ
admet-1427	126	31	and	and	CCONJ
admet-1427	126	32	zwitterionic	zwitterionic	ADJ
admet-1427	126	33	properties	property	NOUN
admet-1427	126	34	.	.	PUNCT
admet-1427	127	1	the	the	DET
admet-1427	127	2	high	high	ADJ
admet-1427	127	3	pe	pe	PROPN
admet-1427	127	4	values	value	NOUN
admet-1427	127	5	of	of	ADP
admet-1427	127	6	fqs	fqs	NOUN
admet-1427	127	7	in	in	ADP
admet-1427	127	8	sl	sl	NOUN
admet-1427	127	9	-	-	PUNCT
admet-1427	127	10	pampa	pampa	NOUN
admet-1427	127	11	are	be	AUX
admet-1427	127	12	in	in	ADP
admet-1427	127	13	good	good	ADJ
admet-1427	127	14	agreement	agreement	NOUN
admet-1427	127	15	with	with	ADP
admet-1427	127	16	that	that	SCONJ
admet-1427	127	17	these	these	DET
admet-1427	127	18	fqs	fqs	NOUN
admet-1427	127	19	show	show	VERB
admet-1427	127	20	good	good	ADJ
admet-1427	127	21	oral	oral	ADJ
admet-1427	127	22	bioavailability	bioavailability	NOUN
admet-1427	127	23	.	.	PUNCT
admet-1427	128	1	even	even	ADV
admet-1427	128	2	in	in	ADP
admet-1427	128	3	the	the	DET
admet-1427	128	4	case	case	NOUN
admet-1427	128	5	of	of	ADP
admet-1427	128	6	most	most	ADJ
admet-1427	128	7	hydrophilic	hydrophilic	ADJ
admet-1427	128	8	fqs	fqs	PROPN
admet-1427	128	9	,	,	PUNCT
admet-1427	128	10	nflx	nflx	PROPN
admet-1427	128	11	(	(	PUNCT
admet-1427	128	12	log	log	NOUN
admet-1427	128	13	d	d	X
admet-1427	128	14	=	=	NOUN
admet-1427	128	15	1.35	1.35	NUM
admet-1427	128	16	)	)	PUNCT
admet-1427	128	17	and	and	CCONJ
admet-1427	128	18	cpfx	cpfx	NOUN
admet-1427	128	19	(	(	PUNCT
admet-1427	128	20	log	log	NOUN
admet-1427	128	21	d	d	NOUN
admet-1427	128	22	=	=	NOUN
admet-1427	128	23	1.38	1.38	NUM
admet-1427	128	24	)	)	PUNCT
admet-1427	128	25	,	,	PUNCT
admet-1427	128	26	the	the	DET
admet-1427	128	27	bioavailability	bioavailability	NOUN
admet-1427	128	28	is	be	AUX
admet-1427	128	29	moderate	moderate	ADJ
admet-1427	128	30	and	and	CCONJ
admet-1427	128	31	high	high	ADJ
admet-1427	128	32	(	(	PUNCT
admet-1427	128	33	>	>	X
admet-1427	128	34	38	38	NUM
admet-1427	128	35	%	%	NOUN
admet-1427	128	36	and	and	CCONJ
admet-1427	128	37	83	83	NUM
admet-1427	128	38	%	%	NOUN
admet-1427	128	39	,	,	PUNCT
admet-1427	128	40	respectively	respectively	ADV
admet-1427	128	41	)	)	PUNCT
admet-1427	129	1	[	[	X
admet-1427	129	2	20,21	20,21	NUM
admet-1427	129	3	]	]	PUNCT
admet-1427	129	4	.	.	PUNCT
admet-1427	130	1	these	these	DET
admet-1427	130	2	results	result	NOUN
admet-1427	130	3	suggested	suggest	VERB
admet-1427	130	4	that	that	SCONJ
admet-1427	130	5	sl	sl	NOUN
admet-1427	130	6	-	-	PUNCT
admet-1427	130	7	pampa	pampa	NOUN
admet-1427	130	8	is	be	AUX
admet-1427	130	9	suitable	suitable	ADJ
admet-1427	130	10	to	to	PART
admet-1427	130	11	assess	assess	VERB
admet-1427	130	12	the	the	DET
admet-1427	130	13	effect	effect	NOUN
admet-1427	130	14	of	of	ADP
admet-1427	130	15	metal	metal	NOUN
admet-1427	130	16	ions	ion	NOUN
admet-1427	130	17	on	on	ADP
admet-1427	130	18	the	the	DET
admet-1427	130	19	intestinal	intestinal	ADJ
admet-1427	130	20	membrane	membrane	NOUN
admet-1427	130	21	permeation	permeation	NOUN
admet-1427	130	22	of	of	ADP
admet-1427	130	23	zwitterionic	zwitterionic	ADJ
admet-1427	130	24	drugs	drug	NOUN
admet-1427	130	25	.	.	PUNCT
admet-1427	131	1	the	the	DET
admet-1427	131	2	pe	pe	PROPN
admet-1427	131	3	values	value	NOUN
admet-1427	131	4	of	of	ADP
admet-1427	131	5	nflx	nflx	PROPN
admet-1427	131	6	and	and	CCONJ
admet-1427	131	7	cpfx	cpfx	NOUN
admet-1427	131	8	are	be	AUX
admet-1427	131	9	about	about	ADV
admet-1427	131	10	10	10	NUM
admet-1427	131	11	times	time	NOUN
admet-1427	131	12	higher	high	ADJ
admet-1427	131	13	than	than	ADP
admet-1427	131	14	previously	previously	ADV
admet-1427	131	15	reported	report	VERB
admet-1427	131	16	values	value	NOUN
admet-1427	131	17	in	in	ADP
admet-1427	131	18	pion	pion	NOUN
admet-1427	131	19	’s	’s	PART
admet-1427	131	20	pampa	pampa	PROPN
admet-1427	131	21	,	,	PUNCT
admet-1427	131	22	which	which	PRON
admet-1427	131	23	uses	use	VERB
admet-1427	131	24	a	a	DET
admet-1427	131	25	20	20	NUM
admet-1427	131	26	%	%	NOUN
admet-1427	131	27	dodecane	dodecane	NOUN
admet-1427	131	28	solution	solution	NOUN
admet-1427	131	29	of	of	ADP
admet-1427	131	30	a	a	DET
admet-1427	131	31	lecithin	lecithin	NOUN
admet-1427	131	32	mixture	mixture	NOUN
admet-1427	131	33	[	[	X
admet-1427	131	34	19,22	19,22	X
admet-1427	131	35	]	]	X
admet-1427	131	36	.	.	PUNCT
admet-1427	132	1	as	as	SCONJ
admet-1427	132	2	log	log	PROPN
admet-1427	132	3	d	d	NOUN
admet-1427	132	4	was	be	AUX
admet-1427	132	5	increased	increase	VERB
admet-1427	132	6	,	,	PUNCT
admet-1427	132	7	the	the	DET
admet-1427	132	8	pe	pe	PROPN
admet-1427	132	9	value	value	NOUN
admet-1427	132	10	was	be	AUX
admet-1427	132	11	increased	increase	VERB
admet-1427	132	12	until	until	ADP
admet-1427	132	13	reaching	reach	VERB
admet-1427	132	14	the	the	DET
admet-1427	132	15	plateau	plateau	NOUN
admet-1427	132	16	value	value	NOUN
admet-1427	132	17	(	(	PUNCT
admet-1427	132	18	about	about	ADV
admet-1427	132	19	30	30	NUM
admet-1427	132	20	×	×	NOUN
admet-1427	132	21	10	10	NUM
admet-1427	132	22	-	-	SYM
admet-1427	132	23	6	6	NUM
admet-1427	132	24	cm	cm	NOUN
admet-1427	132	25	/	/	SYM
admet-1427	132	26	s	s	PROPN
admet-1427	132	27	at	at	ADP
admet-1427	132	28	log	log	PROPN
admet-1427	133	1	d	d	X
admet-1427	133	2	>	>	X
admet-1427	133	3	0	0	NUM
admet-1427	133	4	)	)	PUNCT
admet-1427	133	5	(	(	PUNCT
admet-1427	133	6	figure	figure	NOUN
admet-1427	133	7	2a	2a	NUM
admet-1427	133	8	)	)	PUNCT
admet-1427	133	9	.	.	PUNCT
admet-1427	134	1	this	this	DET
admet-1427	134	2	plateau	plateau	NOUN
admet-1427	134	3	value	value	NOUN
admet-1427	134	4	would	would	AUX
admet-1427	134	5	be	be	AUX
admet-1427	134	6	attributed	attribute	VERB
admet-1427	134	7	to	to	ADP
admet-1427	134	8	the	the	DET
admet-1427	134	9	unstirred	unstirred	ADJ
admet-1427	134	10	water	water	NOUN
admet-1427	134	11	layer	layer	NOUN
admet-1427	134	12	adjacent	adjacent	ADJ
admet-1427	134	13	to	to	ADP
admet-1427	134	14	the	the	DET
admet-1427	134	15	pampa	pampa	NOUN
admet-1427	134	16	membrane	membrane	NOUN
admet-1427	134	17	[	[	X
admet-1427	134	18	23	23	NUM
admet-1427	134	19	]	]	PUNCT
admet-1427	134	20	.	.	PUNCT
admet-1427	135	1	as	as	SCONJ
admet-1427	135	2	shown	show	VERB
admet-1427	135	3	in	in	ADP
admet-1427	135	4	figure	figure	NOUN
admet-1427	135	5	2b	2b	NOUN
admet-1427	135	6	,	,	PUNCT
admet-1427	135	7	pampa	pampa	PROPN
admet-1427	135	8	pe	pe	PROPN
admet-1427	135	9	was	be	AUX
admet-1427	135	10	also	also	ADV
admet-1427	135	11	positively	positively	ADV
admet-1427	135	12	correlated	correlate	VERB
admet-1427	135	13	with	with	ADP
admet-1427	135	14	mw	mw	PROPN
admet-1427	135	15	.	.	PUNCT
admet-1427	136	1	the	the	DET
admet-1427	136	2	observed	observe	VERB
admet-1427	136	3	correlation	correlation	NOUN
admet-1427	136	4	between	between	ADP
admet-1427	136	5	log	log	NOUN
admet-1427	136	6	pe	pe	PROPN
admet-1427	136	7	and	and	CCONJ
admet-1427	136	8	mw	mw	PROPN
admet-1427	136	9	may	may	AUX
admet-1427	136	10	be	be	AUX
admet-1427	136	11	a	a	DET
admet-1427	136	12	mere	mere	ADJ
admet-1427	136	13	coincidence	coincidence	NOUN
admet-1427	136	14	due	due	ADP
admet-1427	136	15	to	to	ADP
admet-1427	136	16	the	the	DET
admet-1427	136	17	choice	choice	NOUN
admet-1427	136	18	of	of	ADP
admet-1427	136	19	fqs	fqs	NOUN
admet-1427	136	20	,	,	PUNCT
admet-1427	136	21	but	but	CCONJ
admet-1427	136	22	it	it	PRON
admet-1427	136	23	may	may	AUX
admet-1427	136	24	also	also	ADV
admet-1427	136	25	be	be	AUX
admet-1427	136	26	explained	explain	VERB
admet-1427	136	27	as	as	SCONJ
admet-1427	136	28	follows	follow	VERB
admet-1427	136	29	.	.	PUNCT
admet-1427	137	1	according	accord	VERB
admet-1427	137	2	to	to	ADP
admet-1427	137	3	the	the	DET
admet-1427	137	4	solubility	solubility	NOUN
admet-1427	137	5	-	-	PUNCT
admet-1427	137	6	diffusion	diffusion	NOUN
admet-1427	137	7	theory	theory	NOUN
admet-1427	137	8	[	[	X
admet-1427	137	9	24,25	24,25	NUM
admet-1427	137	10	]	]	PUNCT
admet-1427	137	11	,	,	PUNCT
admet-1427	137	12	partition	partition	NOUN
admet-1427	137	13	and	and	CCONJ
admet-1427	137	14	diffusion	diffusion	NOUN
admet-1427	137	15	processes	process	NOUN
admet-1427	137	16	determine	determine	VERB
admet-1427	137	17	the	the	DET
admet-1427	137	18	lipid	lipid	ADJ
admet-1427	137	19	membrane	membrane	NOUN
admet-1427	137	20	permeation	permeation	NOUN
admet-1427	137	21	of	of	ADP
admet-1427	137	22	a	a	DET
admet-1427	137	23	drug	drug	NOUN
admet-1427	137	24	.	.	PUNCT
admet-1427	138	1	as	as	ADP
admet-1427	138	2	mw	mw	ADJ
admet-1427	138	3	increases	increase	NOUN
admet-1427	138	4	,	,	PUNCT
admet-1427	138	5	the	the	DET
admet-1427	138	6	diffusion	diffusion	NOUN
admet-1427	138	7	coefficient	coefficient	NOUN
admet-1427	138	8	decreases	decrease	VERB
admet-1427	138	9	.	.	PUNCT
admet-1427	139	1	on	on	ADP
admet-1427	139	2	the	the	DET
admet-1427	139	3	other	other	ADJ
admet-1427	139	4	hand	hand	NOUN
admet-1427	139	5	,	,	PUNCT
admet-1427	139	6	the	the	DET
admet-1427	139	7	partition	partition	NOUN
admet-1427	139	8	process	process	NOUN
admet-1427	139	9	depends	depend	VERB
admet-1427	139	10	on	on	ADP
admet-1427	139	11	the	the	DET
admet-1427	139	12	lipophilicity	lipophilicity	NOUN
admet-1427	139	13	of	of	ADP
admet-1427	139	14	a	a	DET
admet-1427	139	15	drug	drug	NOUN
admet-1427	139	16	.	.	PUNCT
admet-1427	140	1	the	the	DET
admet-1427	140	2	lipophilicity	lipophilicity	NOUN
admet-1427	140	3	of	of	ADP
admet-1427	140	4	a	a	DET
admet-1427	140	5	drug	drug	NOUN
admet-1427	140	6	is	be	AUX
admet-1427	140	7	determined	determine	VERB
admet-1427	140	8	by	by	ADP
admet-1427	140	9	the	the	DET
admet-1427	140	10	balance	balance	NOUN
admet-1427	140	11	of	of	ADP
admet-1427	140	12	drug	drug	NOUN
admet-1427	140	13	-	-	PUNCT
admet-1427	140	14	solvent	solvent	NOUN
admet-1427	140	15	interactions	interaction	NOUN
admet-1427	140	16	(	(	PUNCT
admet-1427	140	17	e.g.	e.g.	ADV
admet-1427	140	18	,	,	PUNCT
admet-1427	140	19	hydrogen	hydrogen	NOUN
admet-1427	140	20	bonding	bonding	NOUN
admet-1427	140	21	)	)	PUNCT
admet-1427	140	22	and	and	CCONJ
admet-1427	140	23	the	the	DET
admet-1427	140	24	cavity	cavity	NOUN
admet-1427	140	25	effect	effect	NOUN
admet-1427	140	26	,	,	PUNCT
admet-1427	140	27	the	the	DET
admet-1427	140	28	latter	latter	NOUN
admet-1427	140	29	of	of	ADP
admet-1427	140	30	which	which	PRON
admet-1427	140	31	is	be	AUX
admet-1427	140	32	proportional	proportional	ADJ
admet-1427	140	33	to	to	AUX
admet-1427	140	34	mw	mw	PROPN
admet-1427	140	35	.	.	PROPN
admet-1427	141	1	therefore	therefore	ADV
admet-1427	141	2	,	,	PUNCT
admet-1427	141	3	when	when	SCONJ
admet-1427	141	4	drug	drug	NOUN
admet-1427	141	5	-	-	PUNCT
admet-1427	141	6	solvent	solvent	NOUN
admet-1427	141	7	interaction	interaction	NOUN
admet-1427	141	8	is	be	AUX
admet-1427	141	9	similar	similar	ADJ
admet-1427	141	10	(	(	PUNCT
admet-1427	141	11	like	like	ADP
admet-1427	141	12	among	among	ADP
admet-1427	141	13	fq	fq	PROPN
admet-1427	141	14	series	series	PROPN
admet-1427	141	15	)	)	PUNCT
admet-1427	141	16	,	,	PUNCT
admet-1427	141	17	log	log	VERB
admet-1427	141	18	d	d	NOUN
admet-1427	141	19	increase	increase	NOUN
admet-1427	141	20	with	with	ADP
admet-1427	141	21	mw	mw	PROPN
admet-1427	141	22	(	(	PUNCT
admet-1427	141	23	figure	figure	NOUN
admet-1427	141	24	2c	2c	NUM
admet-1427	141	25	)	)	PUNCT
admet-1427	141	26	.	.	PUNCT
admet-1427	142	1	in	in	ADP
admet-1427	142	2	most	most	ADJ
admet-1427	142	3	cases	case	NOUN
admet-1427	142	4	of	of	ADP
admet-1427	142	5	drug	drug	NOUN
admet-1427	142	6	membrane	membrane	NOUN
admet-1427	142	7	permeation	permeation	NOUN
admet-1427	142	8	,	,	PUNCT
admet-1427	142	9	the	the	DET
admet-1427	142	10	influence	influence	NOUN
admet-1427	142	11	of	of	ADP
admet-1427	142	12	a	a	DET
admet-1427	142	13	partition	partition	NOUN
admet-1427	142	14	process	process	NOUN
admet-1427	142	15	is	be	AUX
admet-1427	142	16	greater	great	ADJ
admet-1427	142	17	than	than	ADP
admet-1427	142	18	that	that	PRON
admet-1427	142	19	of	of	ADP
admet-1427	142	20	a	a	DET
admet-1427	142	21	diffusion	diffusion	NOUN
admet-1427	142	22	process	process	NOUN
admet-1427	142	23	.	.	PUNCT
admet-1427	143	1	it	it	PRON
admet-1427	143	2	is	be	AUX
admet-1427	143	3	well	well	ADV
admet-1427	143	4	known	know	VERB
admet-1427	143	5	that	that	SCONJ
admet-1427	143	6	the	the	DET
admet-1427	143	7	membrane	membrane	NOUN
admet-1427	143	8	permeability	permeability	NOUN
admet-1427	143	9	of	of	ADP
admet-1427	143	10	drugs	drug	NOUN
admet-1427	143	11	correlates	correlate	VERB
admet-1427	143	12	with	with	ADP
admet-1427	143	13	their	their	PRON
admet-1427	143	14	lipophilicity	lipophilicity	NOUN
admet-1427	143	15	[	[	X
admet-1427	143	16	9	9	NUM
admet-1427	143	17	]	]	PUNCT
admet-1427	143	18	.	.	PUNCT
admet-1427	144	1	therefore	therefore	ADV
admet-1427	144	2	,	,	PUNCT
admet-1427	144	3	even	even	ADV
admet-1427	144	4	though	though	SCONJ
admet-1427	144	5	an	an	DET
admet-1427	144	6	increase	increase	NOUN
admet-1427	144	7	in	in	ADP
admet-1427	144	8	mw	mw	ADJ
admet-1427	144	9	decreases	decrease	NOUN
admet-1427	144	10	the	the	DET
admet-1427	144	11	diffusion	diffusion	NOUN
admet-1427	144	12	process	process	NOUN
admet-1427	144	13	,	,	PUNCT
admet-1427	144	14	pe	pe	PROPN
admet-1427	144	15	can	can	AUX
admet-1427	144	16	show	show	VERB
admet-1427	144	17	a	a	DET
admet-1427	144	18	positive	positive	ADJ
admet-1427	144	19	correlation	correlation	NOUN
admet-1427	144	20	with	with	ADP
admet-1427	144	21	mw	mw	NOUN
admet-1427	144	22	.	.	PROPN
admet-1427	144	23	more	more	ADV
admet-1427	144	24	detailed	detailed	ADJ
admet-1427	144	25	analysis	analysis	NOUN
admet-1427	144	26	is	be	AUX
admet-1427	144	27	required	require	VERB
admet-1427	144	28	to	to	PART
admet-1427	144	29	further	far	ADV
admet-1427	144	30	investigate	investigate	VERB
admet-1427	144	31	this	this	DET
admet-1427	144	32	point	point	NOUN
admet-1427	144	33	,	,	PUNCT
admet-1427	144	34	such	such	ADJ
admet-1427	144	35	as	as	ADP
admet-1427	144	36	using	use	VERB
admet-1427	144	37	abraham	abraham	PROPN
admet-1427	144	38	’s	’s	PART
admet-1427	144	39	solute	solute	PROPN
admet-1427	144	40	descriptors	descriptor	NOUN
admet-1427	144	41	[	[	X
admet-1427	144	42	26	26	NUM
admet-1427	144	43	]	]	PUNCT
admet-1427	144	44	.	.	PUNCT
admet-1427	145	1	in	in	ADP
admet-1427	145	2	this	this	DET
admet-1427	145	3	study	study	NOUN
admet-1427	145	4	,	,	PUNCT
admet-1427	145	5	metal	metal	NOUN
admet-1427	145	6	ions	ion	NOUN
admet-1427	145	7	are	be	AUX
admet-1427	145	8	added	add	VERB
admet-1427	145	9	as	as	ADP
admet-1427	145	10	chloride	chloride	NOUN
admet-1427	145	11	salts	salt	NOUN
admet-1427	145	12	because	because	SCONJ
admet-1427	145	13	they	they	PRON
admet-1427	145	14	are	be	AUX
admet-1427	145	15	soluble	soluble	ADJ
admet-1427	145	16	in	in	ADP
admet-1427	145	17	aqueous	aqueous	ADJ
admet-1427	145	18	media	medium	NOUN
admet-1427	145	19	.	.	PUNCT
admet-1427	146	1	the	the	DET
admet-1427	146	2	pe	pe	PROPN
admet-1427	146	3	ratio	ratio	NOUN
admet-1427	146	4	of	of	ADP
admet-1427	146	5	nflx	nflx	PROPN
admet-1427	146	6	was	be	AUX
admet-1427	146	7	in	in	ADP
admet-1427	146	8	good	good	ADJ
admet-1427	146	9	agreement	agreement	NOUN
admet-1427	146	10	with	with	ADP
admet-1427	146	11	the	the	DET
admet-1427	146	12	cmax	cmax	NOUN
admet-1427	146	13	and	and	CCONJ
admet-1427	146	14	auc	auc	NOUN
admet-1427	146	15	ratios	ratio	NOUN
admet-1427	146	16	observed	observe	VERB
admet-1427	146	17	in	in	ADP
admet-1427	146	18	dogs	dog	NOUN
admet-1427	146	19	(	(	PUNCT
admet-1427	146	20	figure	figure	NOUN
admet-1427	146	21	4	4	NUM
admet-1427	146	22	)	)	PUNCT
admet-1427	147	1	[	[	X
admet-1427	147	2	18	18	NUM
admet-1427	147	3	]	]	PUNCT
admet-1427	147	4	.	.	PUNCT
admet-1427	148	1	in	in	ADP
admet-1427	148	2	that	that	DET
admet-1427	148	3	study	study	NOUN
admet-1427	148	4	,	,	PUNCT
admet-1427	148	5	nflx	nflx	PROPN
admet-1427	148	6	was	be	AUX
admet-1427	148	7	administered	administer	VERB
admet-1427	148	8	as	as	ADP
admet-1427	148	9	a	a	DET
admet-1427	148	10	0.01	0.01	NUM
admet-1427	148	11	n	n	PRON
admet-1427	148	12	hcl	hcl	NOUN
admet-1427	148	13	solution	solution	NOUN
admet-1427	148	14	with	with	ADP
admet-1427	148	15	the	the	DET
admet-1427	148	16	metal	metal	NOUN
admet-1427	148	17	chloride	chloride	NOUN
admet-1427	148	18	salts	salt	NOUN
admet-1427	148	19	.	.	PUNCT
admet-1427	149	1	therefore	therefore	ADV
admet-1427	149	2	,	,	PUNCT
admet-1427	149	3	the	the	DET
admet-1427	149	4	dissolution	dissolution	ADJ
admet-1427	149	5	process	process	NOUN
admet-1427	149	6	of	of	ADP
admet-1427	149	7	fqs	fqs	PROPN
admet-1427	149	8	and	and	CCONJ
admet-1427	149	9	multivalent	multivalent	NOUN
admet-1427	149	10	metal	metal	NOUN
admet-1427	149	11	salt	salt	NOUN
admet-1427	149	12	formulations	formulation	NOUN
admet-1427	149	13	were	be	AUX
admet-1427	149	14	neglected	neglect	VERB
admet-1427	149	15	.	.	PUNCT
admet-1427	150	1	the	the	DET
admet-1427	150	2	effect	effect	NOUN
admet-1427	150	3	of	of	ADP
admet-1427	150	4	mg2	mg2	PROPN
admet-1427	150	5	+	+	X
admet-1427	150	6	in	in	ADP
admet-1427	150	7	dogs	dog	NOUN
admet-1427	150	8	was	be	AUX
admet-1427	150	9	slightly	slightly	ADV
admet-1427	150	10	overestimated	overestimate	VERB
admet-1427	150	11	by	by	ADP
admet-1427	150	12	pampa	pampa	PROPN
admet-1427	150	13	.	.	PUNCT
admet-1427	151	1	the	the	DET
admet-1427	151	2	reason	reason	NOUN
admet-1427	151	3	for	for	ADP
admet-1427	151	4	this	this	PRON
admet-1427	151	5	was	be	AUX
admet-1427	151	6	not	not	PART
admet-1427	151	7	clear	clear	ADJ
admet-1427	151	8	.	.	PUNCT
admet-1427	152	1	however	however	ADV
admet-1427	152	2	,	,	PUNCT
admet-1427	152	3	in	in	ADP
admet-1427	152	4	clinical	clinical	ADJ
admet-1427	152	5	cases	case	NOUN
admet-1427	152	6	where	where	SCONJ
admet-1427	152	7	these	these	DET
admet-1427	152	8	formulations	formulation	NOUN
admet-1427	152	9	are	be	AUX
admet-1427	152	10	administered	administer	VERB
admet-1427	152	11	as	as	ADP
admet-1427	152	12	solid	solid	ADJ
admet-1427	152	13	dosage	dosage	NOUN
admet-1427	152	14	forms	form	NOUN
admet-1427	152	15	,	,	PUNCT
admet-1427	152	16	pampa	pampa	PROPN
admet-1427	152	17	tended	tend	VERB
admet-1427	152	18	to	to	PART
admet-1427	152	19	overpredict	overpredict	VERB
admet-1427	152	20	the	the	DET
admet-1427	152	21	reduction	reduction	NOUN
admet-1427	152	22	of	of	ADP
admet-1427	152	23	auc	auc	NOUN
admet-1427	152	24	and	and	CCONJ
admet-1427	152	25	cmax	cmax	NOUN
admet-1427	152	26	,	,	PUNCT
admet-1427	152	27	especially	especially	ADV
admet-1427	152	28	for	for	ADP
admet-1427	152	29	al3	al3	NOUN
admet-1427	152	30	+	+	CCONJ
admet-1427	152	31	and	and	CCONJ
admet-1427	152	32	la3	la3	NOUN
admet-1427	152	33	+	+	CCONJ
admet-1427	152	34	formulations	formulation	NOUN
admet-1427	152	35	(	(	PUNCT
admet-1427	152	36	figure	figure	NOUN
admet-1427	152	37	3	3	NUM
admet-1427	152	38	)	)	PUNCT
admet-1427	152	39	.	.	PUNCT
admet-1427	153	1	in	in	ADP
admet-1427	153	2	clinical	clinical	ADJ
admet-1427	153	3	formulations	formulation	NOUN
admet-1427	153	4	,	,	PUNCT
admet-1427	153	5	al3	al3	PROPN
admet-1427	153	6	+	+	CCONJ
admet-1427	153	7	is	be	AUX
admet-1427	153	8	contained	contain	VERB
admet-1427	153	9	as	as	ADP
admet-1427	153	10	dried	dry	VERB
admet-1427	153	11	aluminum	aluminum	NOUN
admet-1427	153	12	hydroxide	hydroxide	NOUN
admet-1427	153	13	gel	gel	NOUN
admet-1427	153	14	and	and	CCONJ
admet-1427	153	15	la3	la3	NOUN
admet-1427	153	16	+	+	CCONJ
admet-1427	153	17	is	be	AUX
admet-1427	153	18	contained	contain	VERB
admet-1427	153	19	as	as	ADP
admet-1427	153	20	la2(co3)3・8h2o	la2(co3)3・8h2o	PROPN
admet-1427	153	21	.	.	PUNCT
admet-1427	154	1	ca2	ca2	PROPN
admet-1427	154	2	+	+	PROPN
admet-1427	154	3	,	,	PUNCT
admet-1427	154	4	mg2	mg2	PROPN
admet-1427	154	5	+	+	PROPN
admet-1427	154	6	,	,	PUNCT
admet-1427	154	7	fe2	fe2	PROPN
admet-1427	154	8	+	+	PROPN
admet-1427	154	9	,	,	PUNCT
admet-1427	154	10	and	and	CCONJ
admet-1427	154	11	zn2	zn2	PROPN
admet-1427	154	12	+	+	PRON
admet-1427	154	13	are	be	AUX
admet-1427	154	14	also	also	ADV
admet-1427	154	15	formulated	formulate	VERB
admet-1427	154	16	as	as	ADP
admet-1427	154	17	the	the	DET
admet-1427	154	18	other	other	ADJ
admet-1427	154	19	solid	solid	ADJ
admet-1427	154	20	forms	form	NOUN
admet-1427	154	21	(	(	PUNCT
admet-1427	154	22	caco3	caco3	NOUN
admet-1427	154	23	,	,	PUNCT
admet-1427	154	24	mgo	mgo	PROPN
admet-1427	154	25	,	,	PUNCT
admet-1427	154	26	etc	etc	X
admet-1427	154	27	.	.	X
admet-1427	154	28	)	)	PUNCT
admet-1427	154	29	.	.	PUNCT
admet-1427	155	1	some	some	PRON
admet-1427	155	2	of	of	ADP
admet-1427	155	3	these	these	DET
admet-1427	155	4	solid	solid	ADJ
admet-1427	155	5	forms	form	NOUN
admet-1427	155	6	would	would	AUX
admet-1427	155	7	dissolve	dissolve	VERB
admet-1427	155	8	slowly	slowly	ADV
admet-1427	155	9	in	in	ADP
admet-1427	155	10	the	the	DET
admet-1427	155	11	intestinal	intestinal	ADJ
admet-1427	155	12	fluid	fluid	NOUN
admet-1427	155	13	so	so	ADV
admet-1427	155	14	fqs	fqs	NOUN
admet-1427	155	15	can	can	AUX
admet-1427	155	16	be	be	AUX
admet-1427	155	17	absorbed	absorb	VERB
admet-1427	155	18	before	before	SCONJ
admet-1427	155	19	metal	metal	NOUN
admet-1427	155	20	ions	ion	NOUN
admet-1427	155	21	are	be	AUX
admet-1427	155	22	released	release	VERB
admet-1427	155	23	from	from	ADP
admet-1427	155	24	the	the	DET
admet-1427	155	25	formulations	formulation	NOUN
admet-1427	155	26	,	,	PUNCT
admet-1427	155	27	especially	especially	ADV
admet-1427	155	28	for	for	ADP
admet-1427	155	29	high	high	ADJ
admet-1427	155	30	permeability	permeability	NOUN
admet-1427	155	31	fqs	fqs	ADJ
admet-1427	155	32	.	.	PUNCT
admet-1427	156	1	for	for	ADP
admet-1427	156	2	example	example	NOUN
admet-1427	156	3	,	,	PUNCT
admet-1427	156	4	the	the	DET
admet-1427	156	5	dissolution	dissolution	NOUN
admet-1427	156	6	of	of	ADP
admet-1427	156	7	la2(co3)3・8h2o	la2(co3)3・8h2o	PROPN
admet-1427	156	8	is	be	AUX
admet-1427	156	9	about	about	ADV
admet-1427	156	10	50	50	NUM
admet-1427	156	11	%	%	NOUN
admet-1427	156	12	at	at	ADP
admet-1427	156	13	15	15	NUM
admet-1427	156	14	min	min	NOUN
admet-1427	156	15	in	in	ADP
admet-1427	156	16	the	the	DET
admet-1427	156	17	gastric	gastric	ADJ
admet-1427	156	18	environment	environment	NOUN
admet-1427	156	19	of	of	ADP
admet-1427	156	20	ph	ph	PROPN
admet-1427	156	21	1.2	1.2	NUM
admet-1427	156	22	and	and	CCONJ
admet-1427	156	23	there	there	PRON
admet-1427	156	24	is	be	VERB
admet-1427	156	25	little	little	ADJ
admet-1427	156	26	dissolution	dissolution	NOUN
admet-1427	156	27	in	in	ADP
admet-1427	156	28	the	the	DET
admet-1427	156	29	intestinal	intestinal	ADJ
admet-1427	156	30	environment	environment	NOUN
admet-1427	156	31	of	of	ADP
admet-1427	156	32	ph	ph	PROPN
admet-1427	156	33	6.8	6.8	NUM
admet-1427	157	1	[	[	X
admet-1427	157	2	27	27	NUM
admet-1427	157	3	]	]	PUNCT
admet-1427	157	4	.	.	PUNCT
admet-1427	158	1	for	for	ADP
admet-1427	158	2	more	more	ADJ
admet-1427	158	3	quantitative	quantitative	ADJ
admet-1427	158	4	prediction	prediction	NOUN
admet-1427	158	5	,	,	PUNCT
admet-1427	158	6	the	the	DET
admet-1427	158	7	dissolution	dissolution	NOUN
admet-1427	158	8	of	of	ADP
admet-1427	158	9	a	a	DET
admet-1427	158	10	metal	metal	NOUN
admet-1427	158	11	ion	ion	NOUN
admet-1427	158	12	formulation	formulation	NOUN
admet-1427	158	13	and	and	CCONJ
admet-1427	158	14	the	the	DET
admet-1427	158	15	permeation	permeation	NOUN
admet-1427	158	16	of	of	ADP
admet-1427	158	17	an	an	DET
admet-1427	158	18	fq	fq	PROPN
admet-1427	158	19	should	should	AUX
admet-1427	158	20	be	be	AUX
admet-1427	158	21	simultaneously	simultaneously	ADV
admet-1427	158	22	evaluated	evaluate	VERB
admet-1427	158	23	.	.	PUNCT
admet-1427	159	1	admet	admet	PROPN
admet-1427	159	2	&	&	CCONJ
admet-1427	159	3	dmpk	dmpk	PROPN
admet-1427	159	4	10(4	10(4	NUM
admet-1427	159	5	)	)	PUNCT
admet-1427	159	6	(	(	PUNCT
admet-1427	159	7	2022	2022	NUM
admet-1427	159	8	)	)	PUNCT
admet-1427	159	9	289	289	NUM
admet-1427	159	10	-	-	PUNCT
admet-1427	159	11	297	297	NUM
admet-1427	159	12	artificial	artificial	ADJ
admet-1427	159	13	membrane	membrane	NOUN
admet-1427	159	14	permeation	permeation	NOUN
admet-1427	159	15	of	of	ADP
admet-1427	159	16	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	159	17	doi	doi	NOUN
admet-1427	159	18	:	:	PUNCT
admet-1427	159	19	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	X
admet-1427	159	20	295	295	NUM
admet-1427	159	21	the	the	DET
admet-1427	159	22	detailed	detailed	ADJ
admet-1427	159	23	analysis	analysis	NOUN
admet-1427	159	24	of	of	ADP
admet-1427	159	25	equilibria	equilibrium	NOUN
admet-1427	159	26	between	between	ADP
admet-1427	159	27	fqs	fqs	ADJ
admet-1427	159	28	and	and	CCONJ
admet-1427	159	29	metal	metal	NOUN
admet-1427	159	30	ions	ion	NOUN
admet-1427	159	31	is	be	AUX
admet-1427	159	32	out	out	ADP
admet-1427	159	33	of	of	ADP
admet-1427	159	34	the	the	DET
admet-1427	159	35	scope	scope	NOUN
admet-1427	159	36	of	of	ADP
admet-1427	159	37	this	this	DET
admet-1427	159	38	study	study	NOUN
admet-1427	159	39	,	,	PUNCT
admet-1427	159	40	as	as	SCONJ
admet-1427	159	41	it	it	PRON
admet-1427	159	42	has	have	AUX
admet-1427	159	43	been	be	AUX
admet-1427	159	44	reported	report	VERB
admet-1427	159	45	for	for	ADP
admet-1427	159	46	some	some	PRON
admet-1427	159	47	of	of	ADP
admet-1427	159	48	the	the	DET
admet-1427	159	49	fqs	fqs	NOUN
admet-1427	160	1	[	[	X
admet-1427	160	2	28	28	NUM
admet-1427	160	3	]	]	PUNCT
admet-1427	160	4	.	.	PUNCT
admet-1427	161	1	previously	previously	ADV
admet-1427	161	2	,	,	PUNCT
admet-1427	161	3	wallis	wallis	PROPN
admet-1427	161	4	et	et	PROPN
admet-1427	161	5	al	al	PROPN
admet-1427	161	6	.	.	PROPN
admet-1427	161	7	reported	report	VERB
admet-1427	161	8	that	that	SCONJ
admet-1427	161	9	the	the	DET
admet-1427	161	10	formation	formation	NOUN
admet-1427	161	11	constant	constant	ADJ
admet-1427	161	12	of	of	ADP
admet-1427	161	13	the	the	DET
admet-1427	161	14	nflx	nflx	ADJ
admet-1427	161	15	–	–	PUNCT
admet-1427	161	16	metal	metal	NOUN
admet-1427	161	17	ion	ion	NOUN
admet-1427	161	18	complex	complex	NOUN
admet-1427	161	19	correlates	correlate	VERB
admet-1427	161	20	with	with	ADP
admet-1427	161	21	in	in	ADP
admet-1427	161	22	vivo	vivo	ADJ
admet-1427	161	23	bioavailability	bioavailability	NOUN
admet-1427	161	24	in	in	ADP
admet-1427	161	25	dogs	dog	NOUN
admet-1427	161	26	[	[	X
admet-1427	161	27	18	18	NUM
admet-1427	161	28	]	]	PUNCT
admet-1427	161	29	.	.	PUNCT
admet-1427	162	1	the	the	DET
admet-1427	162	2	chelate	chelate	NOUN
admet-1427	162	3	formation	formation	NOUN
admet-1427	162	4	constant	constant	ADJ
admet-1427	162	5	(	(	PUNCT
admet-1427	162	6	log	log	NOUN
admet-1427	162	7	unit	unit	NOUN
admet-1427	162	8	)	)	PUNCT
admet-1427	162	9	and	and	CCONJ
admet-1427	162	10	the	the	DET
admet-1427	162	11	percentage	percentage	NOUN
admet-1427	162	12	of	of	ADP
admet-1427	162	13	nflx	nflx	PROPN
admet-1427	162	14	complexed	complexe	VERB
admet-1427	162	15	at	at	ADP
admet-1427	162	16	ph	ph	PROPN
admet-1427	162	17	6.5	6.5	NUM
admet-1427	162	18	are	be	AUX
admet-1427	162	19	reported	report	VERB
admet-1427	162	20	to	to	PART
admet-1427	162	21	be	be	AUX
admet-1427	162	22	2.2	2.2	NUM
admet-1427	162	23	(	(	PUNCT
admet-1427	162	24	8.5	8.5	NUM
admet-1427	162	25	%	%	NOUN
admet-1427	162	26	)	)	PUNCT
admet-1427	162	27	,	,	PUNCT
admet-1427	162	28	3.0	3.0	NUM
admet-1427	162	29	(	(	PUNCT
admet-1427	162	30	35	35	NUM
admet-1427	162	31	%	%	NOUN
admet-1427	162	32	)	)	PUNCT
admet-1427	162	33	,	,	PUNCT
admet-1427	162	34	3.8	3.8	NUM
admet-1427	162	35	(	(	PUNCT
admet-1427	162	36	81	81	NUM
admet-1427	162	37	%	%	NOUN
admet-1427	162	38	)	)	PUNCT
admet-1427	162	39	,	,	PUNCT
admet-1427	162	40	4.0	4.0	NUM
admet-1427	162	41	(	(	PUNCT
admet-1427	162	42	78	78	NUM
admet-1427	162	43	%	%	NOUN
admet-1427	162	44	)	)	PUNCT
admet-1427	162	45	,	,	PUNCT
admet-1427	162	46	and	and	CCONJ
admet-1427	162	47	7.0	7.0	NUM
admet-1427	162	48	(	(	PUNCT
admet-1427	162	49	99	99	NUM
admet-1427	162	50	%	%	NOUN
admet-1427	162	51	)	)	PUNCT
admet-1427	162	52	for	for	ADP
admet-1427	162	53	ca2	ca2	PROPN
admet-1427	162	54	+	+	PROPN
admet-1427	162	55	,	,	PUNCT
admet-1427	162	56	mg2	mg2	PROPN
admet-1427	162	57	+	+	PROPN
admet-1427	162	58	,	,	PUNCT
admet-1427	162	59	zn2	zn2	PROPN
admet-1427	162	60	+	+	PROPN
admet-1427	162	61	,	,	PUNCT
admet-1427	162	62	fe2	fe2	PROPN
admet-1427	162	63	+	+	PROPN
admet-1427	162	64	,	,	PUNCT
admet-1427	162	65	and	and	CCONJ
admet-1427	162	66	al3	al3	PROPN
admet-1427	162	67	+	+	NOUN
admet-1427	162	68	,	,	PUNCT
admet-1427	162	69	respectively	respectively	ADV
admet-1427	162	70	.	.	PUNCT
admet-1427	163	1	in	in	ADP
admet-1427	163	2	the	the	DET
admet-1427	163	3	present	present	ADJ
admet-1427	163	4	study	study	NOUN
admet-1427	163	5	,	,	PUNCT
admet-1427	163	6	the	the	DET
admet-1427	163	7	trivalent	trivalent	NOUN
admet-1427	163	8	metal	metal	NOUN
admet-1427	163	9	ions	ion	NOUN
admet-1427	163	10	(	(	PUNCT
admet-1427	163	11	al3	al3	PROPN
admet-1427	163	12	+	+	PROPN
admet-1427	163	13	,	,	PUNCT
admet-1427	163	14	fe3	fe3	PROPN
admet-1427	163	15	+	+	PROPN
admet-1427	163	16	,	,	PUNCT
admet-1427	163	17	la3	la3	NOUN
admet-1427	163	18	+	+	ADP
admet-1427	163	19	)	)	PUNCT
admet-1427	163	20	reduced	reduce	VERB
admet-1427	163	21	pe	pe	ADP
admet-1427	163	22	more	more	ADJ
admet-1427	163	23	than	than	ADP
admet-1427	163	24	the	the	DET
admet-1427	163	25	divalent	divalent	ADJ
admet-1427	163	26	metal	metal	NOUN
admet-1427	163	27	ions	ion	NOUN
admet-1427	163	28	.	.	PUNCT
admet-1427	164	1	among	among	ADP
admet-1427	164	2	the	the	DET
admet-1427	164	3	divalent	divalent	ADJ
admet-1427	164	4	metal	metal	NOUN
admet-1427	164	5	ions	ion	NOUN
admet-1427	164	6	,	,	PUNCT
admet-1427	164	7	no	no	DET
admet-1427	164	8	general	general	ADJ
admet-1427	164	9	trend	trend	NOUN
admet-1427	164	10	was	be	AUX
admet-1427	164	11	observed	observe	VERB
admet-1427	164	12	,	,	PUNCT
admet-1427	164	13	except	except	SCONJ
admet-1427	164	14	that	that	PRON
admet-1427	164	15	mg2	mg2	PROPN
admet-1427	164	16	+	+	PROPN
admet-1427	164	17	reduced	reduce	VERB
admet-1427	164	18	pe	pe	ADP
admet-1427	164	19	more	more	ADJ
admet-1427	164	20	than	than	ADP
admet-1427	164	21	ca2	ca2	PROPN
admet-1427	164	22	+	+	X
admet-1427	164	23	in	in	ADP
admet-1427	164	24	all	all	DET
admet-1427	164	25	fqs	fqs	NOUN
admet-1427	164	26	.	.	PUNCT
admet-1427	165	1	this	this	DET
admet-1427	165	2	trend	trend	NOUN
admet-1427	165	3	was	be	AUX
admet-1427	165	4	not	not	PART
admet-1427	165	5	observed	observe	VERB
admet-1427	165	6	in	in	ADP
admet-1427	165	7	tetracyclines	tetracycline	NOUN
admet-1427	165	8	[	[	X
admet-1427	165	9	10	10	NUM
admet-1427	165	10	]	]	PUNCT
admet-1427	165	11	.	.	PUNCT
admet-1427	166	1	conclusion	conclusion	NOUN
admet-1427	166	2	in	in	ADP
admet-1427	166	3	conclusion	conclusion	NOUN
admet-1427	166	4	,	,	PUNCT
admet-1427	166	5	the	the	DET
admet-1427	166	6	pe	pe	PROPN
admet-1427	166	7	values	value	NOUN
admet-1427	166	8	of	of	ADP
admet-1427	166	9	fqs	fqs	NOUN
admet-1427	166	10	are	be	AUX
admet-1427	166	11	relatively	relatively	ADV
admet-1427	166	12	high	high	ADJ
admet-1427	166	13	in	in	ADP
admet-1427	166	14	sl	sl	NOUN
admet-1427	166	15	-	-	PUNCT
admet-1427	166	16	pampa	pampa	NOUN
admet-1427	166	17	.	.	PUNCT
admet-1427	167	1	as	as	SCONJ
admet-1427	167	2	the	the	DET
admet-1427	167	3	pe	pe	PROPN
admet-1427	167	4	ratio	ratio	NOUN
admet-1427	167	5	(	(	PUNCT
admet-1427	167	6	with	with	ADP
admet-1427	167	7	/	/	SYM
admet-1427	167	8	without	without	ADP
admet-1427	167	9	metal	metal	NOUN
admet-1427	167	10	ions	ion	NOUN
admet-1427	167	11	)	)	PUNCT
admet-1427	167	12	becomes	become	VERB
admet-1427	167	13	smaller	small	ADJ
admet-1427	167	14	,	,	PUNCT
admet-1427	167	15	the	the	DET
admet-1427	167	16	reduction	reduction	NOUN
admet-1427	167	17	in	in	ADP
admet-1427	167	18	auc	auc	NOUN
admet-1427	167	19	and	and	CCONJ
admet-1427	167	20	ur	ur	INTJ
admet-1427	167	21	tended	tend	VERB
admet-1427	167	22	to	to	PART
admet-1427	167	23	be	be	AUX
admet-1427	167	24	more	more	ADV
admet-1427	167	25	significant	significant	ADJ
admet-1427	167	26	.	.	PUNCT
admet-1427	168	1	however	however	ADV
admet-1427	168	2	,	,	PUNCT
admet-1427	168	3	the	the	DET
admet-1427	168	4	reduction	reduction	NOUN
admet-1427	168	5	in	in	ADP
admet-1427	168	6	auc	auc	NOUN
admet-1427	168	7	and	and	CCONJ
admet-1427	168	8	ur	ur	INTJ
admet-1427	168	9	is	be	AUX
admet-1427	168	10	overestimated	overestimate	VERB
admet-1427	168	11	for	for	ADP
admet-1427	168	12	low	low	ADJ
admet-1427	168	13	solubility	solubility	NOUN
admet-1427	168	14	metal	metal	NOUN
admet-1427	168	15	ion	ion	NOUN
admet-1427	168	16	formulations	formulation	NOUN
admet-1427	168	17	(	(	PUNCT
admet-1427	168	18	especially	especially	ADV
admet-1427	168	19	al3	al3	PROPN
admet-1427	168	20	+	+	CCONJ
admet-1427	168	21	and	and	CCONJ
admet-1427	168	22	la3	la3	NOUN
admet-1427	168	23	+	+	CCONJ
admet-1427	168	24	formulations	formulation	NOUN
admet-1427	168	25	)	)	PUNCT
admet-1427	168	26	.	.	PUNCT
admet-1427	169	1	in	in	ADP
admet-1427	169	2	such	such	ADJ
admet-1427	169	3	cases	case	NOUN
admet-1427	169	4	,	,	PUNCT
admet-1427	169	5	the	the	DET
admet-1427	169	6	dissolution	dissolution	NOUN
admet-1427	169	7	of	of	ADP
admet-1427	169	8	a	a	DET
admet-1427	169	9	metal	metal	NOUN
admet-1427	169	10	ion	ion	NOUN
admet-1427	169	11	formulation	formulation	NOUN
admet-1427	169	12	and	and	CCONJ
admet-1427	169	13	the	the	DET
admet-1427	169	14	permeation	permeation	NOUN
admet-1427	169	15	of	of	ADP
admet-1427	169	16	an	an	DET
admet-1427	169	17	fq	fq	PROPN
admet-1427	169	18	should	should	AUX
admet-1427	169	19	be	be	AUX
admet-1427	169	20	simultaneously	simultaneously	ADV
admet-1427	169	21	evaluated	evaluate	VERB
admet-1427	169	22	for	for	ADP
admet-1427	169	23	more	more	ADJ
admet-1427	169	24	quantitative	quantitative	ADJ
admet-1427	169	25	prediction	prediction	NOUN
admet-1427	169	26	by	by	ADP
admet-1427	169	27	an	an	DET
admet-1427	169	28	in	in	ADP
admet-1427	169	29	vitro	vitro	X
admet-1427	169	30	experiment	experiment	NOUN
admet-1427	169	31	.	.	PUNCT
admet-1427	170	1	sl	sl	NOUN
admet-1427	170	2	-	-	PUNCT
admet-1427	170	3	pampa	pampa	NOUN
admet-1427	170	4	is	be	AUX
admet-1427	170	5	suitable	suitable	ADJ
admet-1427	170	6	to	to	PART
admet-1427	170	7	evaluate	evaluate	VERB
admet-1427	170	8	the	the	DET
admet-1427	170	9	potential	potential	ADJ
admet-1427	170	10	effect	effect	NOUN
admet-1427	170	11	of	of	ADP
admet-1427	170	12	metal	metal	NOUN
admet-1427	170	13	salt	salt	NOUN
admet-1427	170	14	formulations	formulation	NOUN
admet-1427	170	15	on	on	ADP
admet-1427	170	16	the	the	DET
admet-1427	170	17	bioavailability	bioavailability	NOUN
admet-1427	170	18	of	of	ADP
admet-1427	170	19	fqs	fqs	NOUN
admet-1427	170	20	.	.	PUNCT
admet-1427	171	1	conflict	conflict	NOUN
admet-1427	171	2	of	of	ADP
admet-1427	171	3	interest	interest	NOUN
admet-1427	171	4	:	:	PUNCT
admet-1427	171	5	authors	author	NOUN
admet-1427	171	6	declare	declare	VERB
admet-1427	171	7	no	no	DET
admet-1427	171	8	conflict	conflict	NOUN
admet-1427	171	9	of	of	ADP
admet-1427	171	10	interest	interest	NOUN
admet-1427	171	11	.	.	PUNCT
admet-1427	172	1	references	reference	NOUN
admet-1427	172	2	[	[	X
admet-1427	172	3	1	1	NUM
admet-1427	172	4	]	]	PUNCT
admet-1427	172	5	a.	a.	NOUN
admet-1427	172	6	stojković	stojković	PROPN
admet-1427	172	7	,	,	PUNCT
admet-1427	172	8	l.	l.	PROPN
admet-1427	172	9	tajber	tajber	PROPN
admet-1427	172	10	,	,	PUNCT
admet-1427	172	11	k.j	k.j	PROPN
admet-1427	172	12	.	.	PROPN
admet-1427	172	13	paluch	paluch	PROPN
admet-1427	172	14	,	,	PUNCT
admet-1427	172	15	z.	z.	PROPN
admet-1427	172	16	djurić	djurić	PROPN
admet-1427	172	17	,	,	PUNCT
admet-1427	172	18	j.	j.	PROPN
admet-1427	172	19	parojčić	parojčić	PROPN
admet-1427	172	20	,	,	PUNCT
admet-1427	172	21	o.i	o.i	PROPN
admet-1427	172	22	.	.	PROPN
admet-1427	172	23	corrigan	corrigan	PROPN
admet-1427	172	24	.	.	PUNCT
admet-1427	173	1	biopharmaceutical	biopharmaceutical	ADJ
admet-1427	173	2	characterisation	characterisation	NOUN
admet-1427	173	3	of	of	ADP
admet-1427	173	4	ciprofloxacin	ciprofloxacin	NOUN
admet-1427	173	5	-	-	PUNCT
admet-1427	173	6	metallic	metallic	ADJ
admet-1427	173	7	ion	ion	NOUN
admet-1427	173	8	interactions	interaction	NOUN
admet-1427	173	9	:	:	PUNCT
admet-1427	173	10	comparative	comparative	ADJ
admet-1427	173	11	study	study	NOUN
admet-1427	173	12	into	into	ADP
admet-1427	173	13	the	the	DET
admet-1427	173	14	effect	effect	NOUN
admet-1427	173	15	of	of	ADP
admet-1427	173	16	aluminium	aluminium	NOUN
admet-1427	173	17	,	,	PUNCT
admet-1427	173	18	calcium	calcium	NOUN
admet-1427	173	19	,	,	PUNCT
admet-1427	173	20	zinc	zinc	NOUN
admet-1427	173	21	and	and	CCONJ
admet-1427	173	22	iron	iron	NOUN
admet-1427	173	23	on	on	ADP
admet-1427	173	24	drug	drug	NOUN
admet-1427	173	25	solubility	solubility	NOUN
admet-1427	173	26	and	and	CCONJ
admet-1427	173	27	dissolution	dissolution	NOUN
admet-1427	173	28	.	.	PUNCT
admet-1427	174	1	acta	acta	PROPN
admet-1427	174	2	pharm	pharm	PROPN
admet-1427	174	3	.	.	PUNCT
admet-1427	175	1	64	64	NUM
admet-1427	175	2	(	(	PUNCT
admet-1427	175	3	2014	2014	NUM
admet-1427	175	4	)	)	PUNCT
admet-1427	175	5	77–88	77–88	NUM
admet-1427	175	6	.	.	PUNCT
admet-1427	176	1	https://doi.org/10.2478/acph-2014-0007	https://doi.org/10.2478/acph-2014-0007	NOUN
admet-1427	176	2	.	.	PUNCT
admet-1427	177	1	[	[	X
admet-1427	177	2	2	2	NUM
admet-1427	177	3	]	]	PUNCT
admet-1427	177	4	ž	ž	PROPN
admet-1427	177	5	.	.	PUNCT
admet-1427	177	6	simon	simon	PROPN
admet-1427	177	7	,	,	PUNCT
admet-1427	177	8	b.	b.	PROPN
admet-1427	177	9	katja	katja	PROPN
admet-1427	177	10	,	,	PUNCT
admet-1427	177	11	u.	u.	PROPN
admet-1427	177	12	darko	darko	PROPN
admet-1427	177	13	,	,	PUNCT
admet-1427	177	14	v.	v.	PROPN
admet-1427	177	15	marjan	marjan	PROPN
admet-1427	177	16	,	,	PUNCT
admet-1427	177	17	k.	k.	PROPN
admet-1427	177	18	albin	albin	PROPN
admet-1427	177	19	.	.	PUNCT
admet-1427	178	1	metal	metal	NOUN
admet-1427	178	2	cation	cation	NOUN
admet-1427	178	3	-	-	PUNCT
admet-1427	178	4	fluoroquinolone	fluoroquinolone	NOUN
admet-1427	178	5	complexes	complex	NOUN
admet-1427	178	6	do	do	AUX
admet-1427	178	7	not	not	PART
admet-1427	178	8	permeate	permeate	VERB
admet-1427	178	9	through	through	ADP
admet-1427	178	10	the	the	DET
admet-1427	178	11	intestinal	intestinal	ADJ
admet-1427	178	12	absorption	absorption	NOUN
admet-1427	178	13	barrier	barrier	NOUN
admet-1427	178	14	.	.	PUNCT
admet-1427	179	1	j.	j.	PROPN
admet-1427	179	2	pharm	pharm	PROPN
admet-1427	179	3	.	.	PUNCT
admet-1427	179	4	biomed	biome	VERB
admet-1427	179	5	.	.	PUNCT
admet-1427	180	1	anal	anal	ADJ
admet-1427	180	2	.	.	PUNCT
admet-1427	181	1	53	53	NUM
admet-1427	181	2	(	(	PUNCT
admet-1427	181	3	2010	2010	NUM
admet-1427	181	4	)	)	PUNCT
admet-1427	182	1	655–659	655–659	NUM
admet-1427	182	2	.	.	PUNCT
admet-1427	183	1	https://doi.org/10.1016/j.jpba.2010.05.021	https://doi.org/10.1016/j.jpba.2010.05.021	NOUN
admet-1427	183	2	.	.	PUNCT
admet-1427	184	1	[	[	X
admet-1427	184	2	3	3	X
admet-1427	184	3	]	]	X
admet-1427	184	4	j.t	j.t	PROPN
admet-1427	184	5	.	.	PROPN
admet-1427	184	6	doluisio	doluisio	PROPN
admet-1427	184	7	,	,	PUNCT
admet-1427	184	8	a.n	a.n	PROPN
admet-1427	184	9	.	.	PROPN
admet-1427	184	10	martin	martin	PROPN
admet-1427	184	11	.	.	PUNCT
admet-1427	185	1	metal	metal	NOUN
admet-1427	185	2	complexation	complexation	NOUN
admet-1427	185	3	of	of	ADP
admet-1427	185	4	the	the	DET
admet-1427	185	5	tetracycline	tetracycline	NOUN
admet-1427	185	6	hydrochlorides	hydrochloride	NOUN
admet-1427	185	7	.	.	PUNCT
admet-1427	186	1	j.	j.	PROPN
admet-1427	186	2	med	med	PROPN
admet-1427	186	3	.	.	PROPN
admet-1427	186	4	chem	chem	PROPN
admet-1427	186	5	.	.	PUNCT
admet-1427	187	1	6	6	NUM
admet-1427	187	2	(	(	PUNCT
admet-1427	187	3	1963	1963	NUM
admet-1427	187	4	)	)	PUNCT
admet-1427	187	5	16–20	16–20	NUM
admet-1427	187	6	.	.	PUNCT
admet-1427	188	1	https://doi.org/10.1021/jm00337a003	https://doi.org/10.1021/jm00337a003	NOUN
admet-1427	188	2	.	.	PUNCT
admet-1427	189	1	[	[	X
admet-1427	189	2	4	4	NUM
admet-1427	189	3	]	]	X
admet-1427	189	4	r.	r.	PROPN
admet-1427	189	5	krishna	krishna	PROPN
admet-1427	189	6	,	,	PUNCT
admet-1427	189	7	l.	l.	PROPN
admet-1427	189	8	east	east	PROPN
admet-1427	189	9	,	,	PUNCT
admet-1427	189	10	p.	p.	PROPN
admet-1427	189	11	larson	larson	PROPN
admet-1427	189	12	,	,	PUNCT
admet-1427	189	13	c.	c.	PROPN
admet-1427	189	14	valiathan	valiathan	PROPN
admet-1427	189	15	,	,	PUNCT
admet-1427	189	16	k.	k.	PROPN
admet-1427	189	17	butterfield	butterfield	PROPN
admet-1427	189	18	,	,	PUNCT
admet-1427	189	19	y.	y.	PROPN
admet-1427	189	20	teng	teng	PROPN
admet-1427	189	21	,	,	PUNCT
admet-1427	189	22	m.	m.	PROPN
admet-1427	189	23	hernandez	hernandez	PROPN
admet-1427	189	24	-	-	PUNCT
admet-1427	189	25	illas	illas	PROPN
admet-1427	189	26	.	.	PUNCT
admet-1427	190	1	effect	effect	NOUN
admet-1427	190	2	of	of	ADP
admet-1427	190	3	metalcation	metalcation	NOUN
admet-1427	190	4	antacids	antacid	NOUN
admet-1427	190	5	on	on	ADP
admet-1427	190	6	the	the	DET
admet-1427	190	7	pharmacokinetics	pharmacokinetic	NOUN
admet-1427	190	8	of	of	ADP
admet-1427	190	9	1200	1200	NUM
admet-1427	190	10	mg	mg	NUM
admet-1427	190	11	raltegravir	raltegravir	PROPN
admet-1427	190	12	.	.	PUNCT
admet-1427	191	1	j.	j.	PROPN
admet-1427	191	2	pharm	pharm	PROPN
admet-1427	191	3	.	.	PUNCT
admet-1427	192	1	pharmacol	pharmacol	PROPN
admet-1427	192	2	.	.	PUNCT
admet-1427	193	1	68	68	NUM
admet-1427	193	2	(	(	PUNCT
admet-1427	193	3	2016	2016	NUM
admet-1427	193	4	)	)	PUNCT
admet-1427	193	5	1359–1365	1359–1365	NOUN
admet-1427	193	6	.	.	PUNCT
admet-1427	194	1	https://doi.org/10.1111/jphp.12632	https://doi.org/10.1111/jphp.12632	VERB
admet-1427	194	2	.	.	PUNCT
admet-1427	195	1	[	[	X
admet-1427	195	2	5	5	NUM
admet-1427	195	3	]	]	X
admet-1427	195	4	s.k	s.k	PROPN
admet-1427	195	5	.	.	PROPN
admet-1427	195	6	pitman	pitman	PROPN
admet-1427	195	7	,	,	PUNCT
admet-1427	195	8	u.t.p	u.t.p	NOUN
admet-1427	195	9	.	.	PUNCT
admet-1427	195	10	hoang	hoang	PROPN
admet-1427	195	11	,	,	PUNCT
admet-1427	195	12	c.h	c.h	PROPN
admet-1427	195	13	.	.	PROPN
admet-1427	195	14	wi	wi	PROPN
admet-1427	195	15	,	,	PUNCT
admet-1427	195	16	m.	m.	NOUN
admet-1427	195	17	alsheikh	alsheikh	NOUN
admet-1427	195	18	,	,	PUNCT
admet-1427	195	19	d.a	d.a	PROPN
admet-1427	195	20	.	.	PROPN
admet-1427	195	21	hiner	hiner	PROPN
admet-1427	195	22	,	,	PUNCT
admet-1427	195	23	k.m	k.m	PROPN
admet-1427	195	24	.	.	PROPN
admet-1427	195	25	percival	percival	PROPN
admet-1427	195	26	.	.	PUNCT
admet-1427	196	1	revisiting	revisit	VERB
admet-1427	196	2	oral	oral	ADJ
admet-1427	196	3	fluoroquinolone	fluoroquinolone	NOUN
admet-1427	196	4	and	and	CCONJ
admet-1427	196	5	multivalent	multivalent	NOUN
admet-1427	196	6	cation	cation	NOUN
admet-1427	196	7	drug	drug	NOUN
admet-1427	196	8	-	-	PUNCT
admet-1427	196	9	drug	drug	NOUN
admet-1427	196	10	interactions	interaction	NOUN
admet-1427	196	11	:	:	PUNCT
admet-1427	196	12	are	be	AUX
admet-1427	196	13	they	they	PRON
admet-1427	196	14	still	still	ADV
admet-1427	196	15	relevant	relevant	ADJ
admet-1427	196	16	?	?	PUNCT
admet-1427	196	17	antibiotics	antibiotic	NOUN
admet-1427	196	18	.	.	PUNCT
admet-1427	197	1	8	8	NUM
admet-1427	197	2	(	(	PUNCT
admet-1427	197	3	2019	2019	NUM
admet-1427	197	4	)	)	PUNCT
admet-1427	197	5	.	.	PUNCT
admet-1427	198	1	https://doi.org/10.3390/antibiotics8030108	https://doi.org/10.3390/antibiotics8030108	PROPN
admet-1427	198	2	.	.	PUNCT
admet-1427	199	1	[	[	X
admet-1427	199	2	6	6	NUM
admet-1427	199	3	]	]	PUNCT
admet-1427	199	4	m.	m.	NOUN
admet-1427	199	5	kansy	kansy	PROPN
admet-1427	199	6	,	,	PUNCT
admet-1427	199	7	f.	f.	PROPN
admet-1427	199	8	senner	senner	PROPN
admet-1427	199	9	,	,	PUNCT
admet-1427	199	10	k.	k.	PROPN
admet-1427	199	11	gubernator	gubernator	PROPN
admet-1427	199	12	.	.	PUNCT
admet-1427	200	1	physicochemical	physicochemical	ADJ
admet-1427	200	2	high	high	ADJ
admet-1427	200	3	throughput	throughput	NOUN
admet-1427	200	4	screening	screening	NOUN
admet-1427	200	5	:	:	PUNCT
admet-1427	200	6	parallel	parallel	ADJ
admet-1427	200	7	artificial	artificial	ADJ
admet-1427	200	8	membrane	membrane	NOUN
admet-1427	200	9	permeation	permeation	NOUN
admet-1427	200	10	assay	assay	VERB
admet-1427	200	11	in	in	ADP
admet-1427	200	12	the	the	DET
admet-1427	200	13	description	description	NOUN
admet-1427	200	14	of	of	ADP
admet-1427	200	15	passive	passive	ADJ
admet-1427	200	16	absorption	absorption	NOUN
admet-1427	200	17	processes	process	NOUN
admet-1427	200	18	.	.	PUNCT
admet-1427	201	1	j.	j.	PROPN
admet-1427	201	2	med	med	PROPN
admet-1427	201	3	.	.	PROPN
admet-1427	201	4	chem	chem	PROPN
admet-1427	201	5	.	.	PUNCT
admet-1427	201	6	,	,	PUNCT
admet-1427	201	7	41	41	NUM
admet-1427	201	8	(	(	PUNCT
admet-1427	201	9	1998	1998	NUM
admet-1427	201	10	)	)	PUNCT
admet-1427	201	11	,	,	PUNCT
admet-1427	201	12	1007	1007	NUM
admet-1427	201	13	-	-	SYM
admet-1427	201	14	1010	1010	NUM
admet-1427	201	15	.	.	PUNCT
admet-1427	202	1	https://doi.org/10.1021/jm970530e	https://doi.org/10.1021/jm970530e	VERB
admet-1427	202	2	.	.	PUNCT
admet-1427	203	1	[	[	X
admet-1427	203	2	7	7	NUM
admet-1427	203	3	]	]	PUNCT
admet-1427	203	4	a.	a.	NOUN
admet-1427	203	5	avdeef	avdeef	PROPN
admet-1427	203	6	,	,	PUNCT
admet-1427	203	7	s.	s.	PROPN
admet-1427	203	8	bendels	bendels	PROPN
admet-1427	203	9	,	,	PUNCT
admet-1427	203	10	l.	l.	PROPN
admet-1427	203	11	di	di	PROPN
admet-1427	203	12	,	,	PUNCT
admet-1427	203	13	b.	b.	PROPN
admet-1427	203	14	faller	faller	PROPN
admet-1427	203	15	,	,	PUNCT
admet-1427	203	16	m.	m.	PROPN
admet-1427	203	17	kansy	kansy	PROPN
admet-1427	203	18	,	,	PUNCT
admet-1427	203	19	k.	k.	PROPN
admet-1427	203	20	sugano	sugano	PROPN
admet-1427	203	21	,	,	PUNCT
admet-1427	203	22	y.	y.	PROPN
admet-1427	203	23	yamauchi	yamauchi	PROPN
admet-1427	203	24	.	.	PUNCT
admet-1427	204	1	pampa	pampa	PROPN
admet-1427	204	2	critical	critical	ADJ
admet-1427	204	3	factors	factor	NOUN
admet-1427	204	4	for	for	ADP
admet-1427	204	5	better	well	ADJ
admet-1427	204	6	predictions	prediction	NOUN
admet-1427	204	7	of	of	ADP
admet-1427	204	8	absorption	absorption	NOUN
admet-1427	204	9	.	.	PUNCT
admet-1427	205	1	j.	j.	PROPN
admet-1427	205	2	pharm	pharm	PROPN
admet-1427	205	3	.	.	PUNCT
admet-1427	206	1	sci	sci	PROPN
admet-1427	206	2	.	.	PROPN
admet-1427	207	1	96	96	NUM
admet-1427	207	2	(	(	PUNCT
admet-1427	207	3	2007	2007	NUM
admet-1427	207	4	)	)	PUNCT
admet-1427	207	5	.	.	PUNCT
admet-1427	208	1	https://doi.org/10.1002/jps.21068	https://doi.org/10.1002/jps.21068	PROPN
admet-1427	208	2	.	.	PUNCT
admet-1427	209	1	[	[	X
admet-1427	209	2	8	8	NUM
admet-1427	209	3	]	]	X
admet-1427	209	4	l.	l.	PROPN
admet-1427	209	5	di	di	PROPN
admet-1427	209	6	,	,	PUNCT
admet-1427	209	7	p.	p.	PROPN
admet-1427	209	8	artursson	artursson	PROPN
admet-1427	209	9	,	,	PUNCT
admet-1427	209	10	a.	a.	PROPN
admet-1427	209	11	avdeef	avdeef	PROPN
admet-1427	209	12	,	,	PUNCT
admet-1427	209	13	l.z	l.z	PROPN
admet-1427	209	14	.	.	PROPN
admet-1427	209	15	benet	benet	PROPN
admet-1427	209	16	,	,	PUNCT
admet-1427	209	17	j.b	j.b	PROPN
admet-1427	209	18	.	.	PROPN
admet-1427	209	19	houston	houston	PROPN
admet-1427	209	20	,	,	PUNCT
admet-1427	209	21	m.	m.	PROPN
admet-1427	209	22	kansy	kansy	PROPN
admet-1427	209	23	,	,	PUNCT
admet-1427	209	24	e.h	e.h	PROPN
admet-1427	209	25	.	.	PROPN
admet-1427	209	26	kerns	kerns	PROPN
admet-1427	209	27	,	,	PUNCT
admet-1427	209	28	h.	h.	PROPN
admet-1427	209	29	lennernäs	lennernäs	PROPN
admet-1427	209	30	,	,	PUNCT
admet-1427	209	31	d.a	d.a	PROPN
admet-1427	209	32	.	.	PROPN
admet-1427	209	33	smith	smith	PROPN
admet-1427	209	34	,	,	PUNCT
admet-1427	209	35	k.	k.	PROPN
admet-1427	209	36	sugano	sugano	PROPN
admet-1427	209	37	.	.	PUNCT
admet-1427	210	1	the	the	DET
admet-1427	210	2	critical	critical	ADJ
admet-1427	210	3	role	role	NOUN
admet-1427	210	4	of	of	ADP
admet-1427	210	5	passive	passive	ADJ
admet-1427	210	6	permeability	permeability	NOUN
admet-1427	210	7	in	in	ADP
admet-1427	210	8	designing	design	VERB
admet-1427	210	9	successful	successful	ADJ
admet-1427	210	10	drugs	drug	NOUN
admet-1427	210	11	.	.	PUNCT
admet-1427	211	1	chemmedchem	chemmedchem	PROPN
admet-1427	211	2	.	.	PUNCT
admet-1427	212	1	(	(	PUNCT
admet-1427	212	2	2020	2020	NUM
admet-1427	212	3	)	)	PUNCT
admet-1427	212	4	1862	1862	NUM
admet-1427	212	5	-	-	SYM
admet-1427	212	6	1874	1874	NUM
admet-1427	212	7	.	.	PUNCT
admet-1427	213	1	https://doi.org/10.1002/cmdc.202000419	https://doi.org/10.1002/cmdc.202000419	X
admet-1427	213	2	.	.	PUNCT
admet-1427	214	1	[	[	X
admet-1427	214	2	9	9	NUM
admet-1427	214	3	]	]	PUNCT
admet-1427	214	4	k.	k.	PROPN
admet-1427	214	5	sugano	sugano	PROPN
admet-1427	214	6	,	,	PUNCT
admet-1427	214	7	m.	m.	PROPN
admet-1427	214	8	kansy	kansy	PROPN
admet-1427	214	9	,	,	PUNCT
admet-1427	214	10	p.	p.	PROPN
admet-1427	214	11	artursson	artursson	PROPN
admet-1427	214	12	,	,	PUNCT
admet-1427	214	13	a.	a.	PROPN
admet-1427	214	14	avdeef	avdeef	PROPN
admet-1427	214	15	,	,	PUNCT
admet-1427	214	16	s.	s.	PROPN
admet-1427	214	17	bendels	bendels	PROPN
admet-1427	214	18	,	,	PUNCT
admet-1427	214	19	l.	l.	PROPN
admet-1427	214	20	di	di	PROPN
admet-1427	214	21	,	,	PUNCT
admet-1427	214	22	g.f	g.f	PROPN
admet-1427	214	23	.	.	PROPN
admet-1427	214	24	ecker	ecker	PROPN
admet-1427	214	25	,	,	PUNCT
admet-1427	214	26	b.	b.	PROPN
admet-1427	214	27	faller	faller	PROPN
admet-1427	214	28	,	,	PUNCT
admet-1427	214	29	h.	h.	PROPN
admet-1427	214	30	fischer	fischer	PROPN
admet-1427	214	31	,	,	PUNCT
admet-1427	214	32	g.	g.	PROPN
admet-1427	214	33	gerebtzoff	gerebtzoff	PROPN
admet-1427	214	34	,	,	PUNCT
admet-1427	214	35	h.	h.	PROPN
admet-1427	214	36	lennernaes	lennernaes	PROPN
admet-1427	214	37	,	,	PUNCT
admet-1427	214	38	f.	f.	PROPN
admet-1427	214	39	senner	senner	PROPN
admet-1427	214	40	.	.	PUNCT
admet-1427	215	1	coexistence	coexistence	NOUN
admet-1427	215	2	of	of	ADP
admet-1427	215	3	passive	passive	ADJ
admet-1427	215	4	and	and	CCONJ
admet-1427	215	5	carrier	carrier	NOUN
admet-1427	215	6	-	-	PUNCT
admet-1427	215	7	mediated	mediate	VERB
admet-1427	215	8	processes	process	NOUN
admet-1427	215	9	in	in	ADP
admet-1427	215	10	drug	drug	NOUN
admet-1427	215	11	transport	transport	NOUN
admet-1427	215	12	.	.	PUNCT
admet-1427	216	1	nat	nat	PROPN
admet-1427	216	2	.	.	PUNCT
admet-1427	217	1	rev	rev	PROPN
admet-1427	217	2	.	.	PROPN
admet-1427	217	3	drug	drug	NOUN
admet-1427	217	4	discov	discov	NOUN
admet-1427	217	5	.	.	PUNCT
admet-1427	218	1	9	9	NUM
admet-1427	218	2	(	(	PUNCT
admet-1427	218	3	2010	2010	NUM
admet-1427	218	4	)	)	PUNCT
admet-1427	218	5	597	597	NUM
admet-1427	218	6	-	-	SYM
admet-1427	218	7	614	614	NUM
admet-1427	218	8	.	.	PUNCT
admet-1427	218	9	https://doi.org/10.1038/nrd3187	https://doi.org/10.1038/nrd3187	PROPN
admet-1427	218	10	.	.	PUNCT
admet-1427	219	1	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	VERB
admet-1427	219	2	https://doi.org/10.2478/acph-2014-0007	https://doi.org/10.2478/acph-2014-0007	PROPN
admet-1427	219	3	https://doi.org/10.1016/j.jpba.2010.05.021	https://doi.org/10.1016/j.jpba.2010.05.021	NOUN
admet-1427	219	4	https://doi.org/10.1021/jm00337a003	https://doi.org/10.1021/jm00337a003	PROPN
admet-1427	219	5	https://doi.org/10.1111/jphp.12632	https://doi.org/10.1111/jphp.12632	NOUN
admet-1427	219	6	https://doi.org/10.3390/antibiotics8030108	https://doi.org/10.3390/antibiotics8030108	NOUN
admet-1427	219	7	https://doi.org/10.1021/jm970530e	https://doi.org/10.1021/jm970530e	ADJ
admet-1427	219	8	https://doi.org/10.1002/jps.21068	https://doi.org/10.1002/jps.21068	PROPN
admet-1427	219	9	https://doi.org/10.1002/cmdc.202000419	https://doi.org/10.1002/cmdc.202000419	X
admet-1427	219	10	https://doi.org/10.1038/nrd3187	https://doi.org/10.1038/nrd3187	PROPN
admet-1427	219	11	nakatani	nakatani	ADJ
admet-1427	219	12	and	and	CCONJ
admet-1427	219	13	sugano	sugano	ADJ
admet-1427	219	14	admet	admet	PROPN
admet-1427	219	15	&	&	CCONJ
admet-1427	219	16	dmpk	dmpk	PROPN
admet-1427	219	17	10(4	10(4	NUM
admet-1427	219	18	)	)	PUNCT
admet-1427	219	19	(	(	PUNCT
admet-1427	219	20	2022	2022	NUM
admet-1427	219	21	)	)	PUNCT
admet-1427	219	22	289	289	NUM
admet-1427	219	23	-	-	SYM
admet-1427	219	24	297	297	NUM
admet-1427	219	25	296	296	NUM
admet-1427	219	26	[	[	SYM
admet-1427	219	27	10	10	NUM
admet-1427	219	28	]	]	PUNCT
admet-1427	219	29	s.	s.	PROPN
admet-1427	219	30	yamauchi	yamauchi	PROPN
admet-1427	219	31	,	,	PUNCT
admet-1427	219	32	d.	d.	PROPN
admet-1427	219	33	inoue	inoue	PROPN
admet-1427	219	34	,	,	PUNCT
admet-1427	219	35	k.	k.	PROPN
admet-1427	219	36	sugano	sugano	PROPN
admet-1427	219	37	.	.	PUNCT
admet-1427	220	1	permeation	permeation	NOUN
admet-1427	220	2	characteristics	characteristic	NOUN
admet-1427	220	3	of	of	ADP
admet-1427	220	4	tetracyclines	tetracycline	NOUN
admet-1427	220	5	in	in	ADP
admet-1427	220	6	parallel	parallel	ADJ
admet-1427	220	7	artificial	artificial	ADJ
admet-1427	220	8	membrane	membrane	NOUN
admet-1427	220	9	permeation	permeation	NOUN
admet-1427	220	10	assay	assay	PROPN
admet-1427	220	11	ii	ii	PROPN
admet-1427	220	12	:	:	PUNCT
admet-1427	220	13	effect	effect	NOUN
admet-1427	220	14	of	of	ADP
admet-1427	220	15	divalent	divalent	ADJ
admet-1427	220	16	metal	metal	NOUN
admet-1427	220	17	ions	ion	NOUN
admet-1427	220	18	and	and	CCONJ
admet-1427	220	19	mucin	mucin	NOUN
admet-1427	220	20	.	.	PUNCT
admet-1427	221	1	admet	admet	PROPN
admet-1427	221	2	dmpk	dmpk	PROPN
admet-1427	221	3	8	8	NUM
admet-1427	221	4	(	(	PUNCT
admet-1427	221	5	2020	2020	NUM
admet-1427	221	6	)	)	PUNCT
admet-1427	221	7	129138	129138	NUM
admet-1427	221	8	.	.	PUNCT
admet-1427	222	1	https://doi.org/10.5599/admet.797	https://doi.org/10.5599/admet.797	VERB
admet-1427	222	2	.	.	PUNCT
admet-1427	223	1	[	[	X
admet-1427	223	2	11	11	NUM
admet-1427	223	3	]	]	PUNCT
admet-1427	223	4	s.	s.	PROPN
admet-1427	223	5	yamauchi	yamauchi	PROPN
admet-1427	223	6	,	,	PUNCT
admet-1427	223	7	k.	k.	PROPN
admet-1427	223	8	sugano	sugano	PROPN
admet-1427	223	9	.	.	PUNCT
admet-1427	223	10	permeation	permeation	NOUN
admet-1427	223	11	characteristics	characteristic	NOUN
admet-1427	223	12	of	of	ADP
admet-1427	223	13	tetracyclines	tetracycline	NOUN
admet-1427	223	14	in	in	ADP
admet-1427	223	15	parallel	parallel	ADJ
admet-1427	223	16	artificial	artificial	ADJ
admet-1427	223	17	membrane	membrane	NOUN
admet-1427	223	18	permeation	permeation	NOUN
admet-1427	223	19	assay	assay	NOUN
admet-1427	223	20	.	.	PUNCT
admet-1427	224	1	admet	admet	PROPN
admet-1427	224	2	dmpk	dmpk	PROPN
admet-1427	224	3	7	7	NUM
admet-1427	224	4	(	(	PUNCT
admet-1427	224	5	2019	2019	NUM
admet-1427	224	6	)	)	PUNCT
admet-1427	224	7	151–160	151–160	NUM
admet-1427	224	8	.	.	PUNCT
admet-1427	225	1	https://doi.org/10.5599/admet.657	https://doi.org/10.5599/admet.657	X
admet-1427	225	2	.	.	PUNCT
admet-1427	226	1	[	[	X
admet-1427	226	2	12	12	NUM
admet-1427	226	3	]	]	X
admet-1427	226	4	f.	f.	PROPN
admet-1427	226	5	sörgel	sörgel	PROPN
admet-1427	226	6	,	,	PUNCT
admet-1427	226	7	j.	j.	PROPN
admet-1427	226	8	bulitta	bulitta	PROPN
admet-1427	226	9	,	,	PUNCT
admet-1427	226	10	m.	m.	NOUN
admet-1427	226	11	kinzig	kinzig	PROPN
admet-1427	226	12	-	-	PUNCT
admet-1427	226	13	schippers	schipper	NOUN
admet-1427	226	14	.	.	PUNCT
admet-1427	227	1	pharmakokinetik	pharmakokinetik	NOUN
admet-1427	227	2	der	der	NOUN
admet-1427	227	3	chinolone	chinolone	PROPN
admet-1427	227	4	.	.	PUNCT
admet-1427	228	1	pharmaziein	pharmaziein	PROPN
admet-1427	228	2	unserer	unserer	PROPN
admet-1427	228	3	zeit	zeit	PROPN
admet-1427	228	4	.	.	PUNCT
admet-1427	229	1	(	(	PUNCT
admet-1427	229	2	2001	2001	NUM
admet-1427	229	3	)	)	PUNCT
admet-1427	230	1	418–427	418–427	NUM
admet-1427	230	2	.	.	PUNCT
admet-1427	231	1	https://doi.org/10.1002/1615-1003(200109)30:5<418::aid-pauz418>3.0.co;2%23	https://doi.org/10.1002/1615-1003(200109)30:5<418::aid-pauz418>3.0.co;2%23	ADV
admet-1427	231	2	(	(	PUNCT
admet-1427	231	3	accessed	access	VERB
admet-1427	231	4	august	august	PROPN
admet-1427	231	5	24	24	NUM
admet-1427	231	6	,	,	PUNCT
admet-1427	231	7	2022	2022	NUM
admet-1427	231	8	)	)	PUNCT
admet-1427	231	9	.	.	PUNCT
admet-1427	232	1	[	[	X
admet-1427	232	2	13	13	NUM
admet-1427	232	3	]	]	PUNCT
admet-1427	232	4	m.	m.	NOUN
admet-1427	232	5	caianelo	caianelo	NOUN
admet-1427	232	6	,	,	PUNCT
admet-1427	232	7	c.	c.	PROPN
admet-1427	232	8	rodrigues	rodrigues	PROPN
admet-1427	232	9	-	-	PUNCT
admet-1427	232	10	silva	silva	PROPN
admet-1427	232	11	,	,	PUNCT
admet-1427	232	12	m.g	m.g	PROPN
admet-1427	232	13	.	.	PROPN
admet-1427	232	14	maniero	maniero	PROPN
admet-1427	232	15	,	,	PUNCT
admet-1427	232	16	j.r	j.r	PROPN
admet-1427	232	17	.	.	PROPN
admet-1427	232	18	guimarães	guimarães	PROPN
admet-1427	232	19	.	.	PUNCT
admet-1427	233	1	antimicrobial	antimicrobial	ADJ
admet-1427	233	2	activity	activity	NOUN
admet-1427	233	3	against	against	ADP
admet-1427	233	4	grampositive	grampositive	NOUN
admet-1427	233	5	and	and	CCONJ
admet-1427	233	6	gram	gram	NOUN
admet-1427	233	7	-	-	PUNCT
admet-1427	233	8	negative	negative	ADJ
admet-1427	233	9	bacteria	bacteria	NOUN
admet-1427	233	10	during	during	ADP
admet-1427	233	11	gatifloxacin	gatifloxacin	NOUN
admet-1427	233	12	degradation	degradation	NOUN
admet-1427	233	13	by	by	ADP
admet-1427	233	14	hydroxyl	hydroxyl	NOUN
admet-1427	233	15	radicals	radical	NOUN
admet-1427	233	16	.	.	PUNCT
admet-1427	234	1	environ	environ	PROPN
admet-1427	234	2	.	.	PUNCT
admet-1427	235	1	sci	sci	PROPN
admet-1427	235	2	.	.	PUNCT
admet-1427	235	3	pol	pol	PROPN
admet-1427	235	4	.	.	PUNCT
admet-1427	236	1	res	re	NOUN
admet-1427	236	2	.	.	PROPN
admet-1427	237	1	24	24	NUM
admet-1427	237	2	(	(	PUNCT
admet-1427	237	3	2017	2017	NUM
admet-1427	237	4	)	)	PUNCT
admet-1427	237	5	6288	6288	NUM
admet-1427	237	6	-	-	SYM
admet-1427	237	7	6298	6298	NUM
admet-1427	237	8	.	.	PUNCT
admet-1427	238	1	https://doi.org/10.1007/s11356-016-6972-y	https://doi.org/10.1007/s11356-016-6972-y	INTJ
admet-1427	238	2	.	.	PUNCT
admet-1427	239	1	[	[	X
admet-1427	239	2	14	14	NUM
admet-1427	239	3	]	]	SYM
admet-1427	239	4	levofloxacin	levofloxacin	NOUN
admet-1427	239	5	hydrate	hydrate	ADJ
admet-1427	239	6	drug	drug	NOUN
admet-1427	239	7	product	product	NOUN
admet-1427	239	8	information	information	NOUN
admet-1427	239	9	(	(	PUNCT
admet-1427	239	10	cravit	cravit	NOUN
admet-1427	239	11	tablets	tablet	NOUN
admet-1427	239	12	)	)	PUNCT
admet-1427	239	13	,	,	PUNCT
admet-1427	239	14	daiichi	daiichi	PROPN
admet-1427	239	15	sankyo	sankyo	PROPN
admet-1427	239	16	company	company	PROPN
admet-1427	239	17	,	,	PUNCT
admet-1427	239	18	https://www.info.pmda.go.jp/go/pack/6241013c2024_1_21	https://www.info.pmda.go.jp/go/pack/6241013c2024_1_21	PRON
admet-1427	239	19	(	(	PUNCT
admet-1427	239	20	accessed	access	VERB
admet-1427	239	21	august	august	PROPN
admet-1427	239	22	24	24	NUM
admet-1427	239	23	,	,	PUNCT
admet-1427	239	24	2022	2022	NUM
admet-1427	239	25	)	)	PUNCT
admet-1427	239	26	.	.	PUNCT
admet-1427	240	1	[	[	X
admet-1427	240	2	15	15	NUM
admet-1427	240	3	]	]	X
admet-1427	240	4	p.	p.	NOUN
admet-1427	240	5	ravisankar	ravisankar	PROPN
admet-1427	240	6	,	,	PUNCT
admet-1427	240	7	ch.v.p	ch.v.p	PROPN
admet-1427	240	8	.	.	PUNCT
admet-1427	241	1	rao	rao	PROPN
admet-1427	241	2	,	,	PUNCT
admet-1427	241	3	n.a	n.a	PROPN
admet-1427	241	4	.	.	PROPN
admet-1427	241	5	qureshi	qureshi	PROPN
admet-1427	241	6	,	,	PUNCT
admet-1427	241	7	h.a	h.a	PROPN
admet-1427	241	8	.	.	PROPN
admet-1427	241	9	alsubaie	alsubaie	PROPN
admet-1427	241	10	,	,	PUNCT
admet-1427	241	11	m.k	m.k	PROPN
admet-1427	241	12	.	.	PROPN
admet-1427	241	13	alharbi	alharbi	PROPN
admet-1427	241	14	,	,	PUNCT
admet-1427	241	15	g.i.m	g.i.m	PROPN
admet-1427	241	16	.	.	PROPN
admet-1427	241	17	ali	ali	PROPN
admet-1427	241	18	,	,	PUNCT
admet-1427	241	19	s.m	s.m	PROPN
admet-1427	241	20	.	.	PROPN
admet-1427	241	21	alsanad	alsanad	PROPN
admet-1427	241	22	,	,	PUNCT
admet-1427	241	23	s.a	s.a	PROPN
admet-1427	241	24	.	.	PROPN
admet-1427	241	25	ali	ali	PROPN
admet-1427	241	26	,	,	PUNCT
admet-1427	241	27	s.	s.	PROPN
admet-1427	241	28	mahanand	mahanand	PROPN
admet-1427	241	29	,	,	PUNCT
admet-1427	241	30	s.w	s.w	PROPN
admet-1427	241	31	.	.	PROPN
admet-1427	241	32	`	`	PUNCT
admet-1427	241	33	khan	khan	PROPN
admet-1427	241	34	,	,	PUNCT
admet-1427	241	35	k.t	k.t	PROPN
admet-1427	241	36	.	.	PROPN
admet-1427	241	37	magalhães	magalhães	PROPN
admet-1427	241	38	-	-	PUNCT
admet-1427	241	39	guedes	guede	NOUN
admet-1427	241	40	,	,	PUNCT
admet-1427	241	41	j.i	j.i	PROPN
admet-1427	241	42	.	.	PROPN
admet-1427	241	43	druzian	druzian	PROPN
admet-1427	241	44	,	,	PUNCT
admet-1427	241	45	r.f	r.f	PROPN
admet-1427	241	46	.	.	PROPN
admet-1427	241	47	schwan	schwan	PROPN
admet-1427	241	48	,	,	PUNCT
admet-1427	241	49	i.l	i.l	PROPN
admet-1427	241	50	.	.	PROPN
admet-1427	241	51	nunes	nunes	PROPN
admet-1427	241	52	,	,	PUNCT
admet-1427	241	53	j.a.v	j.a.v	NOUN
admet-1427	241	54	.	.	PUNCT
admet-1427	241	55	costa	costa	PROPN
admet-1427	241	56	,	,	PUNCT
admet-1427	241	57	t.	t.	PROPN
admet-1427	241	58	attard	attard	PROPN
admet-1427	241	59	,	,	PUNCT
admet-1427	241	60	e.	e.	PROPN
admet-1427	241	61	attard	attard	PROPN
admet-1427	241	62	,	,	PUNCT
admet-1427	241	63	l.m	l.m	PROPN
admet-1427	241	64	.	.	PROPN
admet-1427	241	65	shengo	shengo	PROPN
admet-1427	241	66	,	,	PUNCT
admet-1427	241	67	t.h	t.h	PROPN
admet-1427	241	68	.	.	PROPN
admet-1427	241	69	mundongo	mundongo	PROPN
admet-1427	241	70	,	,	PUNCT
admet-1427	242	1	i.u	i.u	PROPN
admet-1427	242	2	.	.	PROPN
admet-1427	242	3	umoh	umoh	PROPN
admet-1427	242	4	,	,	PUNCT
admet-1427	242	5	a.u	a.u	PROPN
admet-1427	242	6	.	.	PROPN
admet-1427	242	7	ekanem	ekanem	PROPN
admet-1427	242	8	,	,	PUNCT
admet-1427	242	9	s.u	s.u	PROPN
admet-1427	242	10	.	.	PROPN
admet-1427	242	11	rehman	rehman	PROPN
admet-1427	242	12	,	,	PUNCT
admet-1427	242	13	h.m	h.m	PROPN
admet-1427	242	14	.	.	PROPN
admet-1427	242	15	rafique	rafique	PROPN
admet-1427	242	16	,	,	PUNCT
admet-1427	242	17	f.a	f.a	PROPN
admet-1427	242	18	.	.	PROPN
admet-1427	242	19	qureshi	qureshi	PROPN
admet-1427	242	20	,	,	PUNCT
admet-1427	242	21	s.	s.	PROPN
admet-1427	242	22	shahid	shahid	PROPN
admet-1427	242	23	,	,	PUNCT
admet-1427	242	24	h.-k	h.-k	PROPN
admet-1427	242	25	.	.	PUNCT
admet-1427	243	1	kang	kang	PROPN
admet-1427	243	2	,	,	PUNCT
admet-1427	243	3	h.-j	h.-j	PROPN
admet-1427	243	4	.	.	PUNCT
admet-1427	244	1	kim	kim	PROPN
admet-1427	244	2	,	,	PUNCT
admet-1427	244	3	j.-s	j.-s	PROPN
admet-1427	244	4	.	.	PUNCT
admet-1427	245	1	kang	kang	PROPN
admet-1427	245	2	,	,	PUNCT
admet-1427	245	3	i.	i.	PROPN
admet-1427	245	4	dey	dey	PROPN
admet-1427	245	5	,	,	PUNCT
admet-1427	245	6	t.k	t.k	PROPN
admet-1427	245	7	.	.	PROPN
admet-1427	245	8	das	das	PROPN
admet-1427	245	9	,	,	PUNCT
admet-1427	245	10	c.	c.	PROPN
admet-1427	245	11	roy	roy	PROPN
admet-1427	245	12	,	,	PUNCT
admet-1427	245	13	m.k	m.k	PROPN
admet-1427	245	14	.	.	PROPN
admet-1427	245	15	pillai	pillai	PROPN
admet-1427	245	16	,	,	PUNCT
admet-1427	245	17	s.	s.	PROPN
admet-1427	245	18	magama	magama	PROPN
admet-1427	245	19	,	,	PUNCT
admet-1427	245	20	l.i	l.i	PROPN
admet-1427	245	21	.	.	PROPN
admet-1427	245	22	santi	santi	PROPN
admet-1427	245	23	,	,	PUNCT
admet-1427	245	24	n.	n.	PROPN
admet-1427	245	25	katsuto	katsuto	PROPN
admet-1427	245	26	,	,	PUNCT
admet-1427	245	27	s.	s.	PROPN
admet-1427	245	28	jin	jin	PROPN
admet-1427	245	29	-	-	PUNCT
admet-1427	245	30	ichi	ichi	PROPN
admet-1427	245	31	,	,	PUNCT
admet-1427	245	32	m.s.t	m.s.t	PROPN
admet-1427	245	33	.	.	PUNCT
admet-1427	245	34	sheikuduman	sheikuduman	PROPN
admet-1427	245	35	,	,	PUNCT
admet-1427	245	36	b.	b.	PROPN
admet-1427	245	37	mangla	mangla	PROPN
admet-1427	245	38	,	,	PUNCT
admet-1427	245	39	a.	a.	PROPN
admet-1427	245	40	jain	jain	PROPN
admet-1427	245	41	,	,	PUNCT
admet-1427	245	42	v.r	v.r	PROPN
admet-1427	245	43	.	.	PROPN
admet-1427	245	44	salunkhe	salunkhe	PROPN
admet-1427	245	45	.	.	PUNCT
admet-1427	246	1	trends	trend	NOUN
admet-1427	246	2	in	in	ADP
admet-1427	246	3	pharmaceutical	pharmaceutical	ADJ
admet-1427	246	4	research	research	NOUN
admet-1427	246	5	and	and	CCONJ
admet-1427	246	6	development	development	NOUN
admet-1427	246	7	vol	vol	NOUN
admet-1427	246	8	.	.	PROPN
admet-1427	247	1	1	1	NUM
admet-1427	247	2	,	,	PUNCT
admet-1427	247	3	book	book	NOUN
admet-1427	247	4	publisher	publisher	NOUN
admet-1427	247	5	international	international	PROPN
admet-1427	247	6	(	(	PUNCT
admet-1427	247	7	a	a	DET
admet-1427	247	8	part	part	NOUN
admet-1427	247	9	of	of	ADP
admet-1427	247	10	sciencedomain	sciencedomain	NOUN
admet-1427	247	11	international	international	ADJ
admet-1427	247	12	)	)	PUNCT
admet-1427	247	13	,	,	PUNCT
admet-1427	247	14	2020	2020	NUM
admet-1427	247	15	.	.	PUNCT
admet-1427	248	1	https://doi.org/10.9734/bpi/tprd/v1	https://doi.org/10.9734/bpi/tprd/v1	X
admet-1427	248	2	.	.	PUNCT
admet-1427	249	1	[	[	X
admet-1427	249	2	16	16	NUM
admet-1427	249	3	]	]	PUNCT
admet-1427	249	4	tosufloxacin	tosufloxacin	PROPN
admet-1427	249	5	tosylate	tosylate	VERB
admet-1427	249	6	drug	drug	NOUN
admet-1427	249	7	product	product	NOUN
admet-1427	249	8	information	information	NOUN
admet-1427	249	9	(	(	PUNCT
admet-1427	249	10	ozex	ozex	NOUN
admet-1427	249	11	tablets	tablet	NOUN
admet-1427	249	12	)	)	PUNCT
admet-1427	249	13	,	,	PUNCT
admet-1427	249	14	fujifilm	fujifilm	PROPN
admet-1427	249	15	toyama	toyama	PROPN
admet-1427	249	16	chemical	chemical	PROPN
admet-1427	249	17	co.	co.	PROPN
admet-1427	249	18	ltd	ltd	PROPN
admet-1427	249	19	.	.	PROPN
admet-1427	249	20	https://www.info.pmda.go.jp/go/pack/6241010f1020_2_06/	https://www.info.pmda.go.jp/go/pack/6241010f1020_2_06/	PROPN
admet-1427	249	21	(	(	PUNCT
admet-1427	249	22	accessed	access	VERB
admet-1427	249	23	august	august	PROPN
admet-1427	249	24	24	24	NUM
admet-1427	249	25	,	,	PUNCT
admet-1427	249	26	2022	2022	NUM
admet-1427	249	27	)	)	PUNCT
admet-1427	249	28	.	.	PUNCT
admet-1427	250	1	[	[	X
admet-1427	250	2	17	17	NUM
admet-1427	250	3	]	]	PUNCT
admet-1427	250	4	a.	a.	NOUN
admet-1427	250	5	avdeef	avdeef	PROPN
admet-1427	250	6	.	.	PUNCT
admet-1427	251	1	absorption	absorption	NOUN
admet-1427	251	2	and	and	CCONJ
admet-1427	251	3	drug	drug	NOUN
admet-1427	251	4	development	development	NOUN
admet-1427	251	5	:	:	PUNCT
admet-1427	251	6	solubility	solubility	NOUN
admet-1427	251	7	,	,	PUNCT
admet-1427	251	8	permeability	permeability	NOUN
admet-1427	251	9	,	,	PUNCT
admet-1427	251	10	and	and	CCONJ
admet-1427	251	11	charge	charge	NOUN
admet-1427	251	12	state	state	NOUN
admet-1427	251	13	,	,	PUNCT
admet-1427	251	14	second	second	ADJ
admet-1427	251	15	edition	edition	NOUN
admet-1427	251	16	,	,	PUNCT
admet-1427	251	17	john	john	PROPN
admet-1427	251	18	wiley	wiley	PROPN
admet-1427	251	19	&	&	CCONJ
admet-1427	251	20	sons	sons	PROPN
admet-1427	251	21	,	,	PUNCT
admet-1427	251	22	inc	inc	PROPN
admet-1427	251	23	.	.	PROPN
admet-1427	251	24	,	,	PUNCT
admet-1427	251	25	2012	2012	NUM
admet-1427	251	26	.	.	PUNCT
admet-1427	252	1	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	X
admet-1427	252	2	.	.	PUNCT
admet-1427	253	1	[	[	X
admet-1427	253	2	18	18	NUM
admet-1427	253	3	]	]	X
admet-1427	253	4	s.c	s.c	PROPN
admet-1427	253	5	.	.	PROPN
admet-1427	253	6	wallis	wallis	PROPN
admet-1427	253	7	,	,	PUNCT
admet-1427	253	8	b.g	b.g	PROPN
admet-1427	253	9	.	.	PROPN
admet-1427	253	10	charles	charles	PROPN
admet-1427	253	11	,	,	PUNCT
admet-1427	253	12	l.r	l.r	PROPN
admet-1427	253	13	.	.	PROPN
admet-1427	253	14	gahan	gahan	PROPN
admet-1427	253	15	,	,	PUNCT
admet-1427	253	16	l.j	l.j	PROPN
admet-1427	253	17	.	.	PROPN
admet-1427	253	18	filippich	filippich	PROPN
admet-1427	253	19	,	,	PUNCT
admet-1427	253	20	m.g	m.g	PROPN
admet-1427	253	21	.	.	PROPN
admet-1427	253	22	bredhauer	bredhauer	PROPN
admet-1427	253	23	,	,	PUNCT
admet-1427	253	24	p.a	p.a	PROPN
admet-1427	253	25	.	.	PROPN
admet-1427	253	26	duckworth	duckworth	NOUN
admet-1427	253	27	.	.	PUNCT
admet-1427	254	1	interaction	interaction	NOUN
admet-1427	254	2	of	of	ADP
admet-1427	254	3	norfloxacin	norfloxacin	PRON
admet-1427	254	4	with	with	ADP
admet-1427	254	5	divalent	divalent	NOUN
admet-1427	254	6	and	and	CCONJ
admet-1427	254	7	trivalent	trivalent	NOUN
admet-1427	254	8	pharmaceutical	pharmaceutical	ADJ
admet-1427	254	9	cations	cation	NOUN
admet-1427	254	10	.	.	PUNCT
admet-1427	255	1	in	in	ADP
admet-1427	255	2	vitro	vitro	X
admet-1427	255	3	complexation	complexation	NOUN
admet-1427	255	4	and	and	CCONJ
admet-1427	255	5	in	in	ADP
admet-1427	255	6	vivo	vivo	ADJ
admet-1427	255	7	pharmacokinetic	pharmacokinetic	ADJ
admet-1427	255	8	studies	study	NOUN
admet-1427	255	9	in	in	ADP
admet-1427	255	10	the	the	DET
admet-1427	255	11	dog	dog	NOUN
admet-1427	255	12	.	.	PUNCT
admet-1427	256	1	j.	j.	PROPN
admet-1427	256	2	pharm	pharm	PROPN
admet-1427	256	3	.	.	PUNCT
admet-1427	257	1	sci	sci	PROPN
admet-1427	257	2	.	.	PROPN
admet-1427	257	3	85	85	NUM
admet-1427	257	4	(	(	PUNCT
admet-1427	257	5	1996	1996	NUM
admet-1427	257	6	)	)	PUNCT
admet-1427	257	7	803–809	803–809	NUM
admet-1427	257	8	.	.	PUNCT
admet-1427	258	1	https://doi.org/10.1021/js960087f	https://doi.org/10.1021/js960087f	PROPN
admet-1427	258	2	.	.	PUNCT
admet-1427	259	1	[	[	X
admet-1427	259	2	19	19	NUM
admet-1427	259	3	]	]	X
admet-1427	259	4	k.y	k.y	PROPN
admet-1427	259	5	.	.	PROPN
admet-1427	259	6	tam	tam	PROPN
admet-1427	259	7	,	,	PUNCT
admet-1427	259	8	a.	a.	NOUN
admet-1427	259	9	avdeef	avdeef	PROPN
admet-1427	259	10	,	,	PUNCT
admet-1427	259	11	o.	o.	PROPN
admet-1427	259	12	tsinman	tsinman	NOUN
admet-1427	259	13	,	,	PUNCT
admet-1427	259	14	n.	n.	PROPN
admet-1427	259	15	sun	sun	PROPN
admet-1427	259	16	.	.	PUNCT
admet-1427	260	1	the	the	DET
admet-1427	260	2	permeation	permeation	NOUN
admet-1427	260	3	of	of	ADP
admet-1427	260	4	amphoteric	amphoteric	ADJ
admet-1427	260	5	drugs	drug	NOUN
admet-1427	260	6	through	through	ADP
admet-1427	260	7	artificial	artificial	ADJ
admet-1427	260	8	membranes	membrane	NOUN
admet-1427	260	9	an	an	PRON
admet-1427	260	10	in	in	ADP
admet-1427	260	11	combo	combo	NOUN
admet-1427	260	12	absorption	absorption	NOUN
admet-1427	260	13	model	model	NOUN
admet-1427	260	14	based	base	VERB
admet-1427	260	15	on	on	ADP
admet-1427	260	16	paracellular	paracellular	ADJ
admet-1427	260	17	and	and	CCONJ
admet-1427	260	18	transmembrane	transmembrane	ADJ
admet-1427	260	19	permeability	permeability	NOUN
admet-1427	260	20	.	.	PUNCT
admet-1427	261	1	j.	j.	PROPN
admet-1427	261	2	med	med	PROPN
admet-1427	261	3	.	.	PROPN
admet-1427	261	4	chem	chem	PROPN
admet-1427	261	5	.	.	PUNCT
admet-1427	262	1	53	53	NUM
admet-1427	262	2	(	(	PUNCT
admet-1427	262	3	2010	2010	NUM
admet-1427	262	4	)	)	PUNCT
admet-1427	263	1	392–401	392–401	NUM
admet-1427	263	2	.	.	PUNCT
admet-1427	264	1	https://doi.org/10.1021/jm901421c	https://doi.org/10.1021/jm901421c	NOUN
admet-1427	264	2	.	.	PUNCT
admet-1427	265	1	[	[	X
admet-1427	265	2	20	20	NUM
admet-1427	265	3	]	]	X
admet-1427	265	4	n.	n.	PROPN
admet-1427	265	5	campbell	campbell	PROPN
admet-1427	265	6	,	,	PUNCT
admet-1427	265	7	m.	m.	PROPN
admet-1427	265	8	kara	kara	PROPN
admet-1427	265	9	,	,	PUNCT
admet-1427	265	10	b.	b.	PROPN
admet-1427	265	11	hasinoff	hasinoff	PROPN
admet-1427	265	12	,	,	PUNCT
admet-1427	265	13	w.	w.	PROPN
admet-1427	265	14	haddara	haddara	PROPN
admet-1427	265	15	,	,	PUNCT
admet-1427	265	16	d.	d.	PROPN
admet-1427	265	17	mckay	mckay	PROPN
admet-1427	265	18	.	.	PUNCT
admet-1427	266	1	norfloxacin	norfloxacin	PROPN
admet-1427	266	2	interaction	interaction	NOUN
admet-1427	266	3	with	with	ADP
admet-1427	266	4	antacids	antacid	NOUN
admet-1427	266	5	and	and	CCONJ
admet-1427	266	6	minerals	mineral	NOUN
admet-1427	266	7	.	.	PUNCT
admet-1427	267	1	br	br	PROPN
admet-1427	267	2	.	.	PUNCT
admet-1427	268	1	j.	j.	PROPN
admet-1427	268	2	clin	clin	PROPN
admet-1427	268	3	.	.	PUNCT
admet-1427	269	1	pharmacol	pharmacol	PROPN
admet-1427	269	2	.	.	PUNCT
admet-1427	270	1	33	33	NUM
admet-1427	270	2	(	(	PUNCT
admet-1427	270	3	1992	1992	NUM
admet-1427	270	4	)	)	PUNCT
admet-1427	271	1	115–116	115–116	NUM
admet-1427	271	2	.	.	PUNCT
admet-1427	272	1	https://doi.org/10.1111/j.1365-2125.1992.tb04010.x	https://doi.org/10.1111/j.1365-2125.1992.tb04010.x	NOUN
admet-1427	272	2	.	.	PUNCT
admet-1427	273	1	[	[	X
admet-1427	273	2	21	21	NUM
admet-1427	273	3	]	]	PUNCT
admet-1427	273	4	ciprofloxacin	ciprofloxacin	PROPN
admet-1427	273	5	hcl	hcl	PROPN
admet-1427	273	6	drug	drug	NOUN
admet-1427	273	7	product	product	NOUN
admet-1427	273	8	information	information	NOUN
admet-1427	273	9	(	(	PUNCT
admet-1427	273	10	ciproxan	ciproxan	PROPN
admet-1427	273	11	)	)	PUNCT
admet-1427	273	12	.	.	PUNCT
admet-1427	274	1	bayer	bayer	PROPN
admet-1427	274	2	.	.	PUNCT
admet-1427	275	1	https://www.info.pmda.go.jp/go/pack/6241008f1023_1_23/	https://www.info.pmda.go.jp/go/pack/6241008f1023_1_23/	PROPN
admet-1427	275	2	(	(	PUNCT
admet-1427	275	3	accessed	access	VERB
admet-1427	275	4	august	august	PROPN
admet-1427	275	5	24	24	NUM
admet-1427	275	6	,	,	PUNCT
admet-1427	275	7	2022	2022	NUM
admet-1427	275	8	)	)	PUNCT
admet-1427	275	9	.	.	PUNCT
admet-1427	276	1	[	[	X
admet-1427	276	2	22	22	NUM
admet-1427	276	3	]	]	PUNCT
admet-1427	276	4	m.	m.	NOUN
admet-1427	276	5	bermejo	bermejo	PROPN
admet-1427	276	6	,	,	PUNCT
admet-1427	276	7	a.	a.	NOUN
admet-1427	276	8	avdeef	avdeef	PROPN
admet-1427	276	9	,	,	PUNCT
admet-1427	276	10	a.	a.	NOUN
admet-1427	276	11	ruiz	ruiz	PROPN
admet-1427	276	12	,	,	PUNCT
admet-1427	276	13	r.	r.	PROPN
admet-1427	276	14	nalda	nalda	PROPN
admet-1427	276	15	,	,	PUNCT
admet-1427	276	16	j.a	j.a	PROPN
admet-1427	276	17	.	.	PROPN
admet-1427	276	18	ruell	ruell	PROPN
admet-1427	276	19	,	,	PUNCT
admet-1427	276	20	o.	o.	PROPN
admet-1427	276	21	tsinman	tsinman	PROPN
admet-1427	276	22	,	,	PUNCT
admet-1427	276	23	i.	i.	PROPN
admet-1427	276	24	gonzález	gonzález	PROPN
admet-1427	276	25	,	,	PUNCT
admet-1427	276	26	c.	c.	PROPN
admet-1427	276	27	fernández	fernández	PROPN
admet-1427	276	28	,	,	PUNCT
admet-1427	276	29	g.	g.	PROPN
admet-1427	276	30	sánchez	sánchez	PROPN
admet-1427	276	31	,	,	PUNCT
admet-1427	276	32	t.m	t.m	PROPN
admet-1427	276	33	.	.	PROPN
admet-1427	276	34	garrigues	garrigues	PROPN
admet-1427	276	35	,	,	PUNCT
admet-1427	276	36	v.	v.	ADP
admet-1427	276	37	merino	merino	NOUN
admet-1427	276	38	.	.	PUNCT
admet-1427	277	1	pampa	pampa	VERB
admet-1427	277	2	a	a	DET
admet-1427	277	3	drug	drug	NOUN
admet-1427	277	4	absorption	absorption	NOUN
admet-1427	277	5	in	in	ADP
admet-1427	277	6	vitro	vitro	X
admet-1427	277	7	model	model	NOUN
admet-1427	277	8	:	:	PUNCT
admet-1427	277	9	7	7	X
admet-1427	277	10	.	.	NOUN
admet-1427	277	11	comparing	compare	VERB
admet-1427	277	12	rat	rat	NOUN
admet-1427	277	13	in	in	ADP
admet-1427	277	14	situ	situ	NOUN
admet-1427	277	15	,	,	PUNCT
admet-1427	277	16	caco2	caco2	NOUN
admet-1427	277	17	,	,	PUNCT
admet-1427	277	18	and	and	CCONJ
admet-1427	277	19	pampa	pampa	NOUN
admet-1427	277	20	permeability	permeability	NOUN
admet-1427	277	21	of	of	ADP
admet-1427	277	22	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	277	23	.	.	PUNCT
admet-1427	278	1	eur	eur	PROPN
admet-1427	278	2	.	.	PUNCT
admet-1427	279	1	j.	j.	PROPN
admet-1427	279	2	pharm	pharm	PROPN
admet-1427	279	3	.	.	PUNCT
admet-1427	280	1	sci	sci	PROPN
admet-1427	280	2	.	.	PROPN
admet-1427	280	3	21	21	NUM
admet-1427	280	4	(	(	PUNCT
admet-1427	280	5	2004	2004	NUM
admet-1427	280	6	)	)	PUNCT
admet-1427	280	7	429–441	429–441	NUM
admet-1427	280	8	.	.	PUNCT
admet-1427	280	9	https://doi.org/10.1016/j.ejps.2003.10.009	https://doi.org/10.1016/j.ejps.2003.10.009	NOUN
admet-1427	280	10	.	.	PUNCT
admet-1427	281	1	[	[	X
admet-1427	281	2	23	23	NUM
admet-1427	281	3	]	]	X
admet-1427	281	4	p.e	p.e	PROPN
admet-1427	281	5	.	.	PROPN
admet-1427	281	6	nielsen	nielsen	PROPN
admet-1427	281	7	,	,	PUNCT
admet-1427	281	8	a.	a.	PROPN
admet-1427	281	9	avdeef	avdeef	PROPN
admet-1427	281	10	.	.	PUNCT
admet-1427	282	1	pampa	pampa	VERB
admet-1427	282	2	a	a	DET
admet-1427	282	3	drug	drug	NOUN
admet-1427	282	4	absorption	absorption	NOUN
admet-1427	282	5	in	in	ADP
admet-1427	282	6	vitro	vitro	X
admet-1427	282	7	model	model	NOUN
admet-1427	282	8	:	:	PUNCT
admet-1427	282	9	8	8	NUM
admet-1427	282	10	.	.	PUNCT
admet-1427	282	11	apparent	apparent	ADJ
admet-1427	282	12	filter	filter	NOUN
admet-1427	282	13	porosity	porosity	NOUN
admet-1427	282	14	and	and	CCONJ
admet-1427	282	15	the	the	DET
admet-1427	282	16	unstirred	unstirred	ADJ
admet-1427	282	17	water	water	NOUN
admet-1427	282	18	layer	layer	NOUN
admet-1427	282	19	.	.	PUNCT
admet-1427	283	1	eur	eur	PROPN
admet-1427	283	2	.	.	PUNCT
admet-1427	284	1	j.	j.	PROPN
admet-1427	284	2	pharm	pharm	PROPN
admet-1427	284	3	.	.	PUNCT
admet-1427	285	1	sci	sci	PROPN
admet-1427	285	2	.	.	PROPN
admet-1427	286	1	22	22	NUM
admet-1427	286	2	(	(	PUNCT
admet-1427	286	3	2004	2004	NUM
admet-1427	286	4	)	)	PUNCT
admet-1427	286	5	33–41	33–41	NUM
admet-1427	286	6	.	.	PUNCT
admet-1427	287	1	https://doi.org/10.1016/j.ejps.2004.02.003	https://doi.org/10.1016/j.ejps.2004.02.003	PROPN
admet-1427	287	2	.	.	PUNCT
admet-1427	288	1	[	[	X
admet-1427	288	2	24	24	NUM
admet-1427	288	3	]	]	X
admet-1427	288	4	t.x	t.x	PROPN
admet-1427	288	5	.	.	PUNCT
admet-1427	288	6	xiang	xiang	PROPN
admet-1427	288	7	,	,	PUNCT
admet-1427	288	8	y.h	y.h	PROPN
admet-1427	288	9	.	.	PROPN
admet-1427	288	10	xu	xu	PROPN
admet-1427	288	11	,	,	PUNCT
admet-1427	288	12	b.d	b.d	PROPN
admet-1427	288	13	.	.	PROPN
admet-1427	288	14	anderson	anderson	PROPN
admet-1427	288	15	.	.	PUNCT
admet-1427	289	1	the	the	DET
admet-1427	289	2	barrier	barrier	NOUN
admet-1427	289	3	domain	domain	NOUN
admet-1427	289	4	for	for	ADP
admet-1427	289	5	solute	solute	NOUN
admet-1427	289	6	permeation	permeation	NOUN
admet-1427	289	7	varies	vary	VERB
admet-1427	289	8	with	with	ADP
admet-1427	289	9	lipid	lipid	ADJ
admet-1427	289	10	bilayer	bilayer	NOUN
admet-1427	289	11	phase	phase	NOUN
admet-1427	289	12	structure	structure	NOUN
admet-1427	289	13	.	.	PUNCT
admet-1427	290	1	j.	j.	PROPN
admet-1427	290	2	membr	membr	PROPN
admet-1427	290	3	.	.	PUNCT
admet-1427	291	1	biol	biol	PROPN
admet-1427	291	2	.	.	PUNCT
admet-1427	292	1	165	165	NUM
admet-1427	292	2	(	(	PUNCT
admet-1427	292	3	1998	1998	NUM
admet-1427	292	4	)	)	PUNCT
admet-1427	292	5	77	77	NUM
admet-1427	292	6	-	-	SYM
admet-1427	292	7	90	90	NUM
admet-1427	292	8	.	.	PUNCT
admet-1427	293	1	https://doi.org/10.1007/s002329900422	https://doi.org/10.1007/s002329900422	PRON
admet-1427	293	2	.	.	PUNCT
admet-1427	294	1	[	[	X
admet-1427	294	2	25	25	NUM
admet-1427	294	3	]	]	X
admet-1427	294	4	j.m	j.m	PROPN
admet-1427	294	5	.	.	PROPN
admet-1427	294	6	diamond	diamond	PROPN
admet-1427	294	7	,	,	PUNCT
admet-1427	294	8	y.	y.	PROPN
admet-1427	294	9	katz	katz	PROPN
admet-1427	294	10	.	.	PUNCT
admet-1427	295	1	interpretation	interpretation	NOUN
admet-1427	295	2	of	of	ADP
admet-1427	295	3	nonelectrolyte	nonelectrolyte	NOUN
admet-1427	295	4	partition	partition	NOUN
admet-1427	295	5	coefficients	coefficient	NOUN
admet-1427	295	6	between	between	ADP
admet-1427	295	7	dimyristoyl	dimyristoyl	PROPN
admet-1427	295	8	lecithin	lecithin	NOUN
admet-1427	295	9	and	and	CCONJ
admet-1427	295	10	water	water	NOUN
admet-1427	295	11	.	.	PUNCT
admet-1427	296	1	j.	j.	PROPN
admet-1427	296	2	membr	membr	PROPN
admet-1427	296	3	.	.	PUNCT
admet-1427	297	1	biol	biol	PROPN
admet-1427	297	2	.	.	PUNCT
admet-1427	298	1	17	17	NUM
admet-1427	298	2	(	(	PUNCT
admet-1427	298	3	1974	1974	NUM
admet-1427	298	4	)	)	PUNCT
admet-1427	298	5	121	121	NUM
admet-1427	298	6	-	-	SYM
admet-1427	298	7	154	154	NUM
admet-1427	298	8	.	.	PUNCT
admet-1427	299	1	https://doi.org/10.1007/bf01870176	https://doi.org/10.1007/bf01870176	X
admet-1427	299	2	.	.	PUNCT
admet-1427	300	1	[	[	X
admet-1427	300	2	26	26	NUM
admet-1427	300	3	]	]	X
admet-1427	300	4	m.h	m.h	PROPN
admet-1427	300	5	.	.	PROPN
admet-1427	300	6	abraham	abraham	PROPN
admet-1427	300	7	.	.	PUNCT
admet-1427	301	1	scales	scale	NOUN
admet-1427	301	2	of	of	ADP
admet-1427	301	3	solute	solute	ADJ
admet-1427	301	4	hydrogen	hydrogen	NOUN
admet-1427	301	5	-	-	PUNCT
admet-1427	301	6	bonding	bonding	NOUN
admet-1427	301	7	:	:	PUNCT
admet-1427	301	8	their	their	PRON
admet-1427	301	9	construction	construction	NOUN
admet-1427	301	10	and	and	CCONJ
admet-1427	301	11	application	application	NOUN
admet-1427	301	12	to	to	ADP
admet-1427	301	13	physicochemical	physicochemical	ADJ
admet-1427	301	14	and	and	CCONJ
admet-1427	301	15	biochemical	biochemical	ADJ
admet-1427	301	16	processes	process	NOUN
admet-1427	301	17	.	.	PUNCT
admet-1427	302	1	chem	chem	NOUN
admet-1427	302	2	.	.	PUNCT
admet-1427	303	1	soc	soc	PROPN
admet-1427	303	2	.	.	PUNCT
admet-1427	304	1	rev	rev	PROPN
admet-1427	304	2	.	.	PROPN
admet-1427	304	3	22	22	NUM
admet-1427	304	4	(	(	PUNCT
admet-1427	304	5	1993	1993	NUM
admet-1427	304	6	)	)	PUNCT
admet-1427	304	7	73	73	NUM
admet-1427	304	8	-	-	SYM
admet-1427	304	9	83	83	NUM
admet-1427	304	10	.	.	PUNCT
admet-1427	305	1	https://doi.org/10.1039/cs9932200073	https://doi.org/10.1039/cs9932200073	X
admet-1427	305	2	.	.	PUNCT
admet-1427	306	1	https://doi.org/10.5599/admet.797	https://doi.org/10.5599/admet.797	PROPN
admet-1427	306	2	https://doi.org/10.5599/admet.657	https://doi.org/10.5599/admet.657	INTJ
admet-1427	307	1	https://doi.org/10.1002/1615-1003(200109)30:5%3c418::aid-pauz418%3e3.0.co;2-%23	https://doi.org/10.1002/1615-1003(200109)30:5%3c418::aid-pauz418%3e3.0.co;2-%23	INTJ
admet-1427	307	2	https://doi.org/10.1002/1615-1003(200109)30:5%3c418::aid-pauz418%3e3.0.co;2-%23	https://doi.org/10.1002/1615-1003(200109)30:5%3c418::aid-pauz418%3e3.0.co;2-%23	INTJ
admet-1427	307	3	https://doi.org/10.1007/s11356-016-6972-y	https://doi.org/10.1007/s11356-016-6972-y	PUNCT
admet-1427	307	4	https://www.info.pmda.go.jp/go/pack/6241013c2024_1_21	https://www.info.pmda.go.jp/go/pack/6241013c2024_1_21	PRON
admet-1427	307	5	https://doi.org/10.9734/bpi/tprd/v1	https://doi.org/10.9734/bpi/tprd/v1	NOUN
admet-1427	307	6	https://www.info.pmda.go.jp/go/pack/6241010f1020_2_06/	https://www.info.pmda.go.jp/go/pack/6241010f1020_2_06/	VERB
admet-1427	307	7	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	PRON
admet-1427	307	8	https://doi.org/10.1021/js960087f	https://doi.org/10.1021/js960087f	ADV
admet-1427	307	9	https://doi.org/10.1021/js960087f	https://doi.org/10.1021/js960087f	X
admet-1427	307	10	https://doi.org/10.1021/jm901421c	https://doi.org/10.1021/jm901421c	NOUN
admet-1427	307	11	https://doi.org/10.1111/j.1365-2125.1992.tb04010.x	https://doi.org/10.1111/j.1365-2125.1992.tb04010.x	PROPN
admet-1427	307	12	https://doi.org/10.1111/j.1365-2125.1992.tb04010.x	https://doi.org/10.1111/j.1365-2125.1992.tb04010.x	PROPN
admet-1427	307	13	https://www.info.pmda.go.jp/go/pack/6241008f1023_1_23/	https://www.info.pmda.go.jp/go/pack/6241008f1023_1_23/	PROPN
admet-1427	307	14	https://www.info.pmda.go.jp/go/pack/6241008f1023_1_23/	https://www.info.pmda.go.jp/go/pack/6241008f1023_1_23/	PROPN
admet-1427	307	15	https://doi.org/10.1016/j.ejps.2003.10.009	https://doi.org/10.1016/j.ejps.2003.10.009	PROPN
admet-1427	308	1	https://doi.org/10.1016/j.ejps.2004.02.003	https://doi.org/10.1016/j.ejps.2004.02.003	PROPN
admet-1427	308	2	https://doi.org/10.1016/j.ejps.2004.02.003	https://doi.org/10.1016/j.ejps.2004.02.003	PROPN
admet-1427	308	3	https://doi.org/10.1007/s002329900422	https://doi.org/10.1007/s002329900422	NUM
admet-1427	308	4	https://doi.org/10.1007/bf01870176	https://doi.org/10.1007/bf01870176	NUM
admet-1427	308	5	https://doi.org/10.1039/cs9932200073	https://doi.org/10.1039/cs9932200073	PRON
admet-1427	308	6	https://doi.org/10.1039/cs9932200073	https://doi.org/10.1039/cs9932200073	NUM
admet-1427	308	7	admet	admet	PROPN
admet-1427	308	8	&	&	CCONJ
admet-1427	308	9	dmpk	dmpk	PROPN
admet-1427	308	10	10(4	10(4	NUM
admet-1427	308	11	)	)	PUNCT
admet-1427	308	12	(	(	PUNCT
admet-1427	308	13	2022	2022	NUM
admet-1427	308	14	)	)	PUNCT
admet-1427	308	15	289	289	NUM
admet-1427	308	16	-	-	PUNCT
admet-1427	308	17	297	297	NUM
admet-1427	308	18	artificial	artificial	ADJ
admet-1427	308	19	membrane	membrane	NOUN
admet-1427	308	20	permeation	permeation	NOUN
admet-1427	308	21	of	of	ADP
admet-1427	308	22	fluoroquinolones	fluoroquinolone	NOUN
admet-1427	308	23	doi	doi	NOUN
admet-1427	308	24	:	:	PUNCT
admet-1427	308	25	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	NUM
admet-1427	308	26	297	297	NUM
admet-1427	308	27	[	[	SYM
admet-1427	308	28	27	27	NUM
admet-1427	308	29	]	]	PUNCT
admet-1427	308	30	lanthanum	lanthanum	ADJ
admet-1427	308	31	carbonate	carbonate	NOUN
admet-1427	308	32	granules	granule	NOUN
admet-1427	308	33	drug	drug	NOUN
admet-1427	308	34	product	product	NOUN
admet-1427	308	35	information	information	NOUN
admet-1427	308	36	.	.	PUNCT
admet-1427	309	1	nipro	nipro	ADJ
admet-1427	309	2	corporation	corporation	NOUN
admet-1427	309	3	.	.	PUNCT
admet-1427	310	1	https://med.nipro.co.jp/servlet/servlet.filedownload?file=00p2x00000bcdptean	https://med.nipro.co.jp/servlet/servlet.filedownload?file=00p2x00000bcdptean	NOUN
admet-1427	310	2	(	(	PUNCT
admet-1427	310	3	accessed	access	VERB
admet-1427	310	4	august	august	PROPN
admet-1427	310	5	24	24	NUM
admet-1427	310	6	,	,	PUNCT
admet-1427	310	7	2022	2022	NUM
admet-1427	310	8	)	)	PUNCT
admet-1427	310	9	.	.	PUNCT
admet-1427	311	1	[	[	X
admet-1427	311	2	28	28	NUM
admet-1427	311	3	]	]	X
admet-1427	311	4	b.	b.	PROPN
admet-1427	311	5	urbaniak	urbaniak	PROPN
admet-1427	311	6	,	,	PUNCT
admet-1427	311	7	z.j	z.j	PROPN
admet-1427	311	8	.	.	PROPN
admet-1427	311	9	kokot	kokot	PROPN
admet-1427	311	10	.	.	PUNCT
admet-1427	312	1	analysis	analysis	NOUN
admet-1427	312	2	of	of	ADP
admet-1427	312	3	the	the	DET
admet-1427	312	4	factors	factor	NOUN
admet-1427	312	5	that	that	PRON
admet-1427	312	6	significantly	significantly	ADV
admet-1427	312	7	influence	influence	VERB
admet-1427	312	8	the	the	DET
admet-1427	312	9	stability	stability	NOUN
admet-1427	312	10	of	of	ADP
admet-1427	312	11	fluoroquinolone	fluoroquinolone	NOUN
admet-1427	312	12	-	-	PUNCT
admet-1427	312	13	metal	metal	NOUN
admet-1427	312	14	complexes	complex	NOUN
admet-1427	312	15	.	.	PUNCT
admet-1427	313	1	anal	anal	ADJ
admet-1427	313	2	.	.	PUNCT
admet-1427	314	1	chim	chim	PROPN
admet-1427	314	2	.	.	PUNCT
admet-1427	315	1	acta	acta	PROPN
admet-1427	315	2	647	647	NUM
admet-1427	315	3	(	(	PUNCT
admet-1427	315	4	2009	2009	NUM
admet-1427	315	5	)	)	PUNCT
admet-1427	315	6	54–59	54–59	NUM
admet-1427	315	7	.	.	PUNCT
admet-1427	316	1	https://doi.org/10.1016/j.aca.2009.05.039	https://doi.org/10.1016/j.aca.2009.05.039	PROPN
admet-1427	316	2	.	.	PUNCT
admet-1427	317	1	©	©	NOUN
admet-1427	317	2	2022	2022	NUM
admet-1427	317	3	by	by	ADP
admet-1427	317	4	the	the	DET
admet-1427	317	5	authors	author	NOUN
admet-1427	317	6	;	;	PUNCT
admet-1427	317	7	licensee	licensee	PROPN
admet-1427	317	8	iapc	iapc	PROPN
admet-1427	317	9	,	,	PUNCT
admet-1427	317	10	zagreb	zagreb	PROPN
admet-1427	317	11	,	,	PUNCT
admet-1427	317	12	croatia	croatia	PROPN
admet-1427	317	13	.	.	PUNCT
admet-1427	318	1	this	this	DET
admet-1427	318	2	article	article	NOUN
admet-1427	318	3	is	be	AUX
admet-1427	318	4	an	an	DET
admet-1427	318	5	open	open	ADJ
admet-1427	318	6	-	-	PUNCT
admet-1427	318	7	access	access	NOUN
admet-1427	318	8	article	article	NOUN
admet-1427	318	9	distributed	distribute	VERB
admet-1427	318	10	under	under	ADP
admet-1427	318	11	the	the	DET
admet-1427	318	12	terms	term	NOUN
admet-1427	318	13	and	and	CCONJ
admet-1427	318	14	conditions	condition	NOUN
admet-1427	318	15	of	of	ADP
admet-1427	318	16	the	the	DET
admet-1427	318	17	creative	creative	ADJ
admet-1427	318	18	commons	common	NOUN
admet-1427	318	19	attribution	attribution	NOUN
admet-1427	318	20	license	license	NOUN
admet-1427	318	21	(	(	PUNCT
admet-1427	318	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1427	318	23	)	)	PUNCT
admet-1427	318	24	http://dx.doi.org/10.5599/admet.1427	http://dx.doi.org/10.5599/admet.1427	VERB
admet-1427	318	25	https://med.nipro.co.jp/servlet/servlet.filedownload?file=00p2x00000bcdptean	https://med.nipro.co.jp/servlet/servlet.filedownload?file=00p2x00000bcdptean	NOUN
admet-1427	318	26	https://doi.org/10.1016/j.aca.2009.05.039	https://doi.org/10.1016/j.aca.2009.05.039	NOUN
admet-1427	318	27	https://doi.org/10.1016/j.aca.2009.05.039	https://doi.org/10.1016/j.aca.2009.05.039	PROPN
admet-1427	318	28	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1427	318	29	)	)	PUNCT