id	sid	tid	token	lemma	pos
admet-1465	1	1	development	development	NOUN
admet-1465	1	2	of	of	ADP
admet-1465	1	3	fiber	fiber	NOUN
admet-1465	1	4	optic	optic	NOUN
admet-1465	1	5	in	in	ADP
admet-1465	1	6	vitro	vitro	X
admet-1465	1	7	release	release	NOUN
admet-1465	1	8	method	method	NOUN
admet-1465	1	9	for	for	ADP
admet-1465	1	10	dexamethasone	dexamethasone	NOUN
admet-1465	1	11	oil	oil	NOUN
admet-1465	1	12	solutions	solution	NOUN
admet-1465	1	13	doi	doi	NOUN
admet-1465	1	14	:	:	PUNCT
admet-1465	1	15	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	1	16	315	315	NUM
admet-1465	1	17	admet	admet	X
admet-1465	1	18	&	&	CCONJ
admet-1465	1	19	dmpk	dmpk	PROPN
admet-1465	1	20	10(4	10(4	NUM
admet-1465	1	21	)	)	PUNCT
admet-1465	1	22	(	(	PUNCT
admet-1465	1	23	2022	2022	NUM
admet-1465	1	24	)	)	PUNCT
admet-1465	1	25	315	315	NUM
admet-1465	1	26	-	-	SYM
admet-1465	1	27	329	329	NUM
admet-1465	1	28	;	;	PUNCT
admet-1465	1	29	doi	doi	NOUN
admet-1465	1	30	:	:	PUNCT
admet-1465	1	31	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	1	32	open	open	ADJ
admet-1465	1	33	access	access	NOUN
admet-1465	1	34	:	:	PUNCT
admet-1465	1	35	issn	issn	PROPN
admet-1465	1	36	:	:	PUNCT
admet-1465	1	37	1848	1848	NUM
admet-1465	1	38	-	-	SYM
admet-1465	1	39	7718	7718	NUM
admet-1465	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1465	1	41	original	original	ADJ
admet-1465	1	42	scientific	scientific	ADJ
admet-1465	1	43	paper	paper	NOUN
admet-1465	1	44	development	development	NOUN
admet-1465	1	45	of	of	ADP
admet-1465	1	46	fiber	fiber	NOUN
admet-1465	1	47	optic	optic	NOUN
admet-1465	1	48	in	in	ADP
admet-1465	1	49	vitro	vitro	X
admet-1465	1	50	release	release	NOUN
admet-1465	1	51	testing	testing	NOUN
admet-1465	1	52	method	method	NOUN
admet-1465	1	53	for	for	ADP
admet-1465	1	54	dexamethasone	dexamethasone	NOUN
admet-1465	1	55	release	release	NOUN
admet-1465	1	56	from	from	ADP
admet-1465	1	57	the	the	DET
admet-1465	1	58	oil	oil	NOUN
admet-1465	1	59	solutions	solution	NOUN
admet-1465	1	60	filip	filip	NOUN
admet-1465	1	61	kozlina1	kozlina1	PROPN
admet-1465	1	62	,	,	PUNCT
admet-1465	1	63	ivan	ivan	PROPN
admet-1465	1	64	meštrović1	meštrović1	PROPN
admet-1465	1	65	,	,	PUNCT
admet-1465	1	66	viktor	viktor	PROPN
admet-1465	1	67	novak1	novak1	PROPN
admet-1465	1	68	,	,	PUNCT
admet-1465	1	69	nikola	nikola	PROPN
admet-1465	1	70	marjanović2	marjanović2	PROPN
admet-1465	1	71	and	and	CCONJ
admet-1465	1	72	biserka	biserka	PROPN
admet-1465	1	73	cetinačižmek*2	cetinačižmek*2	VERB
admet-1465	1	74	1	1	NUM
admet-1465	1	75	university	university	NOUN
admet-1465	1	76	of	of	ADP
admet-1465	1	77	zagreb	zagreb	PROPN
admet-1465	1	78	,	,	PUNCT
admet-1465	1	79	faculty	faculty	NOUN
admet-1465	1	80	of	of	ADP
admet-1465	1	81	pharmacy	pharmacy	NOUN
admet-1465	1	82	and	and	CCONJ
admet-1465	1	83	biochemistry	biochemistry	NOUN
admet-1465	1	84	,	,	PUNCT
admet-1465	1	85	a.	a.	NOUN
admet-1465	1	86	kovačića	kovačića	PROPN
admet-1465	1	87	1	1	NUM
admet-1465	1	88	,	,	PUNCT
admet-1465	1	89	10	10	NUM
admet-1465	1	90	000	000	NUM
admet-1465	1	91	zagreb	zagreb	PROPN
admet-1465	1	92	,	,	PUNCT
admet-1465	1	93	croatia	croatia	PROPN
admet-1465	1	94	2	2	NUM
admet-1465	1	95	pliva	pliva	PROPN
admet-1465	1	96	croatia	croatia	PROPN
admet-1465	1	97	ltd	ltd	PROPN
admet-1465	1	98	,	,	PUNCT
admet-1465	1	99	teva	teva	PROPN
admet-1465	1	100	group	group	PROPN
admet-1465	1	101	member	member	PROPN
admet-1465	1	102	,	,	PUNCT
admet-1465	1	103	prilaz	prilaz	PROPN
admet-1465	1	104	baruna	baruna	PROPN
admet-1465	1	105	filipovića	filipovića	PROPN
admet-1465	1	106	25	25	NUM
admet-1465	1	107	,	,	PUNCT
admet-1465	1	108	10	10	NUM
admet-1465	1	109	000	000	NUM
admet-1465	1	110	zagreb	zagreb	PROPN
admet-1465	1	111	,	,	PUNCT
admet-1465	1	112	croatia	croatia	PROPN
admet-1465	1	113	*	*	PUNCT
admet-1465	1	114	corresponding	correspond	VERB
admet-1465	1	115	author	author	NOUN
admet-1465	1	116	:	:	PUNCT
admet-1465	1	117	e	e	NOUN
admet-1465	1	118	-	-	NOUN
admet-1465	1	119	mail	mail	NOUN
admet-1465	1	120	:	:	PUNCT
admet-1465	1	121	biserka.cetina-cizmek@pliva.com	biserka.cetina-cizmek@pliva.com	PROPN
admet-1465	1	122	;	;	PUNCT
admet-1465	1	123	tel	tel	PROPN
admet-1465	1	124	.	.	PUNCT
admet-1465	1	125	:	:	PUNCT
admet-1465	2	1	+385	+385	PROPN
admet-1465	2	2	-	-	SYM
admet-1465	2	3	1	1	NUM
admet-1465	2	4	-	-	PUNCT
admet-1465	2	5	372	372	NUM
admet-1465	2	6	-	-	PUNCT
admet-1465	2	7	2648	2648	NUM
admet-1465	2	8	received	receive	VERB
admet-1465	2	9	:	:	PUNCT
admet-1465	2	10	july	july	PROPN
admet-1465	2	11	19	19	NUM
admet-1465	2	12	,	,	PUNCT
admet-1465	2	13	2022	2022	NUM
admet-1465	2	14	;	;	PUNCT
admet-1465	2	15	revised	revise	VERB
admet-1465	2	16	:	:	PUNCT
admet-1465	2	17	september	september	PROPN
admet-1465	2	18	14	14	NUM
admet-1465	2	19	,	,	PUNCT
admet-1465	2	20	2022	2022	NUM
admet-1465	2	21	;	;	PUNCT
admet-1465	2	22	published	publish	VERB
admet-1465	2	23	:	:	PUNCT
admet-1465	2	24	october	october	PROPN
admet-1465	2	25	11	11	NUM
admet-1465	2	26	,	,	PUNCT
admet-1465	2	27	2022	2022	NUM
admet-1465	2	28	abstract	abstract	NOUN
admet-1465	2	29	for	for	ADP
admet-1465	2	30	many	many	ADJ
admet-1465	2	31	parenteral	parenteral	ADJ
admet-1465	2	32	drugs	drug	NOUN
admet-1465	2	33	,	,	PUNCT
admet-1465	2	34	there	there	PRON
admet-1465	2	35	is	be	VERB
admet-1465	2	36	still	still	ADV
admet-1465	2	37	no	no	DET
admet-1465	2	38	standardized	standardized	ADJ
admet-1465	2	39	method	method	NOUN
admet-1465	2	40	for	for	ADP
admet-1465	2	41	in	in	ADP
admet-1465	2	42	vitro	vitro	X
admet-1465	2	43	release	release	NOUN
admet-1465	2	44	(	(	PUNCT
admet-1465	2	45	ivr	ivr	PROPN
admet-1465	2	46	)	)	PUNCT
admet-1465	2	47	testing	testing	NOUN
admet-1465	2	48	available	available	ADJ
admet-1465	2	49	.	.	PUNCT
admet-1465	3	1	this	this	DET
admet-1465	3	2	article	article	NOUN
admet-1465	3	3	presents	present	VERB
admet-1465	3	4	the	the	DET
admet-1465	3	5	development	development	NOUN
admet-1465	3	6	of	of	ADP
admet-1465	3	7	a	a	DET
admet-1465	3	8	new	new	ADJ
admet-1465	3	9	ivr	ivr	NOUN
admet-1465	3	10	method	method	NOUN
admet-1465	3	11	for	for	ADP
admet-1465	3	12	oil	oil	NOUN
admet-1465	3	13	solutions	solution	NOUN
admet-1465	3	14	using	use	VERB
admet-1465	3	15	a	a	DET
admet-1465	3	16	dialysis	dialysis	NOUN
admet-1465	3	17	membrane	membrane	NOUN
admet-1465	3	18	and	and	CCONJ
admet-1465	3	19	usp	usp	PROPN
admet-1465	3	20	ii	ii	PROPN
admet-1465	3	21	apparatus	apparatus	NOUN
admet-1465	3	22	coupled	couple	VERB
admet-1465	3	23	to	to	ADP
admet-1465	3	24	a	a	DET
admet-1465	3	25	fiber	fiber	NOUN
admet-1465	3	26	optic	optic	NOUN
admet-1465	3	27	uv	uv	NOUN
admet-1465	3	28	-	-	PUNCT
admet-1465	3	29	vis	vis	X
admet-1465	3	30	spectrometer	spectrometer	NOUN
admet-1465	3	31	.	.	PUNCT
admet-1465	4	1	experiments	experiment	NOUN
admet-1465	4	2	were	be	AUX
admet-1465	4	3	performed	perform	VERB
admet-1465	4	4	using	use	VERB
admet-1465	4	5	dexamethasone	dexamethasone	NOUN
admet-1465	4	6	formulations	formulation	NOUN
admet-1465	4	7	containing	contain	VERB
admet-1465	4	8	castor	castor	NOUN
admet-1465	4	9	oil	oil	NOUN
admet-1465	4	10	as	as	ADP
admet-1465	4	11	a	a	DET
admet-1465	4	12	solvent	solvent	NOUN
admet-1465	4	13	with	with	ADP
admet-1465	4	14	the	the	DET
admet-1465	4	15	addition	addition	NOUN
admet-1465	4	16	of	of	ADP
admet-1465	4	17	cosolvents	cosolvent	NOUN
admet-1465	4	18	,	,	PUNCT
admet-1465	4	19	20	20	NUM
admet-1465	4	20	%	%	NOUN
admet-1465	4	21	(	(	PUNCT
admet-1465	4	22	v	v	NOUN
admet-1465	4	23	/	/	SYM
admet-1465	4	24	v	v	NOUN
admet-1465	4	25	)	)	PUNCT
admet-1465	4	26	of	of	ADP
admet-1465	4	27	isopropanol	isopropanol	NOUN
admet-1465	4	28	or	or	CCONJ
admet-1465	4	29	capryol	capryol	NOUN
admet-1465	4	30	®	®	NOUN
admet-1465	4	31	90	90	NUM
admet-1465	4	32	.	.	PUNCT
admet-1465	5	1	based	base	VERB
admet-1465	5	2	on	on	ADP
admet-1465	5	3	solubility	solubility	NOUN
admet-1465	5	4	testing	testing	NOUN
admet-1465	5	5	results	result	NOUN
admet-1465	5	6	,	,	PUNCT
admet-1465	5	7	castor	castor	NOUN
admet-1465	5	8	oil	oil	NOUN
admet-1465	5	9	was	be	AUX
admet-1465	5	10	chosen	choose	VERB
admet-1465	5	11	as	as	ADP
admet-1465	5	12	the	the	DET
admet-1465	5	13	best	good	ADJ
admet-1465	5	14	solvent	solvent	NOUN
admet-1465	5	15	amongst	amongst	ADP
admet-1465	5	16	other	other	ADJ
admet-1465	5	17	vegetable	vegetable	NOUN
admet-1465	5	18	oils	oil	NOUN
admet-1465	5	19	,	,	PUNCT
admet-1465	5	20	while	while	SCONJ
admet-1465	5	21	a	a	DET
admet-1465	5	22	significant	significant	ADJ
admet-1465	5	23	increase	increase	NOUN
admet-1465	5	24	in	in	ADP
admet-1465	5	25	solubility	solubility	NOUN
admet-1465	5	26	was	be	AUX
admet-1465	5	27	obtained	obtain	VERB
admet-1465	5	28	by	by	ADP
admet-1465	5	29	adding	add	VERB
admet-1465	5	30	either	either	PRON
admet-1465	5	31	of	of	ADP
admet-1465	5	32	the	the	DET
admet-1465	5	33	two	two	NUM
admet-1465	5	34	cosolvents	cosolvent	NOUN
admet-1465	5	35	.	.	PUNCT
admet-1465	6	1	partitioning	partition	VERB
admet-1465	6	2	experiments	experiment	NOUN
admet-1465	6	3	were	be	AUX
admet-1465	6	4	performed	perform	VERB
admet-1465	6	5	to	to	PART
admet-1465	6	6	ensure	ensure	VERB
admet-1465	6	7	these	these	DET
admet-1465	6	8	formulations	formulation	NOUN
admet-1465	6	9	could	could	AUX
admet-1465	6	10	achieve	achieve	VERB
admet-1465	6	11	prolonged	prolonged	ADJ
admet-1465	6	12	drug	drug	NOUN
admet-1465	6	13	release	release	NOUN
admet-1465	6	14	.	.	PUNCT
admet-1465	7	1	ivr	ivr	PROPN
admet-1465	7	2	testing	testing	NOUN
admet-1465	7	3	was	be	AUX
admet-1465	7	4	performed	perform	VERB
admet-1465	7	5	with	with	ADP
admet-1465	7	6	model	model	NOUN
admet-1465	7	7	formulations	formulation	NOUN
admet-1465	7	8	and	and	CCONJ
admet-1465	7	9	critical	critical	ADJ
admet-1465	7	10	test	test	NOUN
admet-1465	7	11	parameters	parameter	NOUN
admet-1465	7	12	were	be	AUX
admet-1465	7	13	varied	varied	ADJ
admet-1465	7	14	in	in	ADP
admet-1465	7	15	order	order	NOUN
admet-1465	7	16	to	to	PART
admet-1465	7	17	examine	examine	VERB
admet-1465	7	18	the	the	DET
admet-1465	7	19	method	method	NOUN
admet-1465	7	20	’s	’s	PART
admet-1465	7	21	sensitivity	sensitivity	NOUN
admet-1465	7	22	.	.	PUNCT
admet-1465	8	1	the	the	DET
admet-1465	8	2	developed	develop	VERB
admet-1465	8	3	method	method	NOUN
admet-1465	8	4	was	be	AUX
admet-1465	8	5	sensitive	sensitive	ADJ
admet-1465	8	6	to	to	ADP
admet-1465	8	7	temperature	temperature	NOUN
admet-1465	8	8	and	and	CCONJ
admet-1465	8	9	stirring	stirring	NOUN
admet-1465	8	10	rate	rate	NOUN
admet-1465	8	11	,	,	PUNCT
admet-1465	8	12	while	while	SCONJ
admet-1465	8	13	coupling	couple	VERB
admet-1465	8	14	the	the	DET
admet-1465	8	15	usp	usp	PROPN
admet-1465	8	16	ii	ii	PROPN
admet-1465	8	17	apparatus	apparatus	NOUN
admet-1465	8	18	with	with	ADP
admet-1465	8	19	a	a	DET
admet-1465	8	20	fiber	fiber	NOUN
admet-1465	8	21	optic	optic	NOUN
admet-1465	8	22	uv	uv	NOUN
admet-1465	8	23	-	-	PUNCT
admet-1465	8	24	vis	vis	X
admet-1465	8	25	spectrometer	spectrometer	NOUN
admet-1465	8	26	enabled	enable	VERB
admet-1465	8	27	complete	complete	ADJ
admet-1465	8	28	automation	automation	NOUN
admet-1465	8	29	.	.	PUNCT
admet-1465	9	1	moreover	moreover	ADV
admet-1465	9	2	,	,	PUNCT
admet-1465	9	3	due	due	ADP
admet-1465	9	4	to	to	ADP
admet-1465	9	5	the	the	DET
admet-1465	9	6	interference	interference	NOUN
admet-1465	9	7	of	of	ADP
admet-1465	9	8	excipients	excipient	NOUN
admet-1465	9	9	on	on	ADP
admet-1465	9	10	fiber	fiber	NOUN
admet-1465	9	11	optic	optic	NOUN
admet-1465	9	12	detection	detection	NOUN
admet-1465	9	13	of	of	ADP
admet-1465	9	14	dexamethasone	dexamethasone	NOUN
admet-1465	9	15	during	during	ADP
admet-1465	9	16	the	the	DET
admet-1465	9	17	release	release	NOUN
admet-1465	9	18	testing	testing	NOUN
admet-1465	9	19	,	,	PUNCT
admet-1465	9	20	derivative	derivative	ADJ
admet-1465	9	21	spectroscopy	spectroscopy	NOUN
admet-1465	9	22	was	be	AUX
admet-1465	9	23	successfully	successfully	ADV
admet-1465	9	24	introduced	introduce	VERB
admet-1465	9	25	for	for	ADP
admet-1465	9	26	the	the	DET
admet-1465	9	27	elimination	elimination	NOUN
admet-1465	9	28	of	of	ADP
admet-1465	9	29	the	the	DET
admet-1465	9	30	interference	interference	NOUN
admet-1465	9	31	.	.	PUNCT
admet-1465	10	1	the	the	DET
admet-1465	10	2	developed	develop	VERB
admet-1465	10	3	ivr	ivr	PROPN
admet-1465	10	4	method	method	NOUN
admet-1465	10	5	described	describe	VERB
admet-1465	10	6	herein	herein	NOUN
admet-1465	10	7	could	could	AUX
admet-1465	10	8	be	be	AUX
admet-1465	10	9	useful	useful	ADJ
admet-1465	10	10	in	in	ADP
admet-1465	10	11	preformulation	preformulation	NOUN
admet-1465	10	12	investigations	investigation	NOUN
admet-1465	10	13	and	and	CCONJ
admet-1465	10	14	the	the	DET
admet-1465	10	15	early	early	ADJ
admet-1465	10	16	development	development	NOUN
admet-1465	10	17	of	of	ADP
admet-1465	10	18	novel	novel	ADJ
admet-1465	10	19	formulations	formulation	NOUN
admet-1465	10	20	.	.	PUNCT
admet-1465	11	1	©	©	NOUN
admet-1465	11	2	2022	2022	NUM
admet-1465	11	3	by	by	ADP
admet-1465	11	4	the	the	DET
admet-1465	11	5	authors.this	authors.this	PRON
admet-1465	11	6	article	article	NOUN
admet-1465	11	7	is	be	AUX
admet-1465	11	8	an	an	DET
admet-1465	11	9	open	open	ADJ
admet-1465	11	10	-	-	PUNCT
admet-1465	11	11	access	access	NOUN
admet-1465	11	12	article	article	NOUN
admet-1465	11	13	distributed	distribute	VERB
admet-1465	11	14	under	under	ADP
admet-1465	11	15	the	the	DET
admet-1465	11	16	terms	term	NOUN
admet-1465	11	17	and	and	CCONJ
admet-1465	11	18	conditions	condition	NOUN
admet-1465	11	19	of	of	ADP
admet-1465	11	20	the	the	DET
admet-1465	11	21	creative	creative	ADJ
admet-1465	11	22	commons	common	NOUN
admet-1465	11	23	attribution	attribution	NOUN
admet-1465	11	24	license	license	NOUN
admet-1465	11	25	(	(	PUNCT
admet-1465	11	26	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1465	11	27	)	)	PUNCT
admet-1465	11	28	.	.	PUNCT
admet-1465	12	1	keywords	keyword	NOUN
admet-1465	12	2	dissolution	dissolution	PROPN
admet-1465	12	3	;	;	PUNCT
admet-1465	12	4	prolonged	prolong	VERB
admet-1465	12	5	release	release	NOUN
admet-1465	12	6	injection	injection	NOUN
admet-1465	12	7	;	;	PUNCT
admet-1465	12	8	parenterals	parenteral	NOUN
admet-1465	12	9	;	;	PUNCT
admet-1465	12	10	derivative	derivative	ADJ
admet-1465	12	11	spectroscopy	spectroscopy	NOUN
admet-1465	12	12	introduction	introduction	NOUN
admet-1465	12	13	the	the	DET
admet-1465	12	14	release	release	NOUN
admet-1465	12	15	of	of	ADP
admet-1465	12	16	an	an	DET
admet-1465	12	17	active	active	ADJ
admet-1465	12	18	pharmaceutical	pharmaceutical	ADJ
admet-1465	12	19	ingredient	ingredient	NOUN
admet-1465	12	20	(	(	PUNCT
admet-1465	12	21	api	api	NOUN
admet-1465	12	22	)	)	PUNCT
admet-1465	12	23	from	from	ADP
admet-1465	12	24	a	a	DET
admet-1465	12	25	drug	drug	NOUN
admet-1465	12	26	product	product	NOUN
admet-1465	12	27	is	be	AUX
admet-1465	12	28	a	a	DET
admet-1465	12	29	prerequisite	prerequisite	NOUN
admet-1465	12	30	for	for	ADP
admet-1465	12	31	all	all	DET
admet-1465	12	32	pharmacokinetic	pharmacokinetic	ADJ
admet-1465	12	33	processes	process	NOUN
admet-1465	12	34	as	as	ADV
admet-1465	12	35	well	well	ADV
admet-1465	12	36	as	as	ADP
admet-1465	12	37	the	the	DET
admet-1465	12	38	therapeutic	therapeutic	ADJ
admet-1465	12	39	effect	effect	NOUN
admet-1465	12	40	of	of	ADP
admet-1465	12	41	an	an	DET
admet-1465	12	42	administered	administer	VERB
admet-1465	12	43	drug	drug	NOUN
admet-1465	12	44	.	.	PUNCT
admet-1465	13	1	in	in	ADP
admet-1465	13	2	vitro	vitro	X
admet-1465	13	3	release	release	NOUN
admet-1465	13	4	(	(	PUNCT
admet-1465	13	5	ivr	ivr	PROPN
admet-1465	13	6	)	)	PUNCT
admet-1465	13	7	testing	testing	NOUN
admet-1465	13	8	is	be	AUX
admet-1465	13	9	often	often	ADV
admet-1465	13	10	conducted	conduct	VERB
admet-1465	13	11	early	early	ADV
admet-1465	13	12	in	in	ADP
admet-1465	13	13	the	the	DET
admet-1465	13	14	development	development	NOUN
admet-1465	13	15	of	of	ADP
admet-1465	13	16	drug	drug	NOUN
admet-1465	13	17	products	product	NOUN
admet-1465	13	18	as	as	SCONJ
admet-1465	13	19	it	it	PRON
admet-1465	13	20	can	can	AUX
admet-1465	13	21	potentially	potentially	ADV
admet-1465	13	22	give	give	VERB
admet-1465	13	23	insight	insight	NOUN
admet-1465	13	24	into	into	ADP
admet-1465	13	25	the	the	DET
admet-1465	13	26	viability	viability	NOUN
admet-1465	13	27	of	of	ADP
admet-1465	13	28	the	the	DET
admet-1465	13	29	drug	drug	NOUN
admet-1465	13	30	product	product	NOUN
admet-1465	13	31	and	and	CCONJ
admet-1465	13	32	,	,	PUNCT
admet-1465	13	33	preferably	preferably	ADV
admet-1465	13	34	,	,	PUNCT
admet-1465	13	35	predict	predict	VERB
admet-1465	13	36	its	its	PRON
admet-1465	13	37	in	in	ADP
admet-1465	13	38	vivo	vivo	NOUN
admet-1465	13	39	behaviour	behaviour	NOUN
admet-1465	13	40	.	.	PUNCT
admet-1465	14	1	furthermore	furthermore	ADV
admet-1465	14	2	,	,	PUNCT
admet-1465	14	3	ivr	ivr	PROPN
admet-1465	14	4	test	test	NOUN
admet-1465	14	5	plays	play	VERB
admet-1465	14	6	an	an	DET
admet-1465	14	7	important	important	ADJ
admet-1465	14	8	role	role	NOUN
admet-1465	14	9	in	in	ADP
admet-1465	14	10	quality	quality	NOUN
admet-1465	14	11	control	control	NOUN
admet-1465	14	12	and	and	CCONJ
admet-1465	14	13	regulatory	regulatory	ADJ
admet-1465	14	14	processes	process	NOUN
admet-1465	14	15	for	for	ADP
admet-1465	14	16	some	some	DET
admet-1465	14	17	drug	drug	NOUN
admet-1465	14	18	products	product	NOUN
admet-1465	14	19	[	[	X
admet-1465	14	20	1	1	NUM
admet-1465	14	21	-	-	SYM
admet-1465	14	22	4	4	NUM
admet-1465	14	23	]	]	PUNCT
admet-1465	14	24	.	.	PUNCT
admet-1465	15	1	several	several	ADJ
admet-1465	15	2	standardized	standardized	ADJ
admet-1465	15	3	methods	method	NOUN
admet-1465	15	4	of	of	ADP
admet-1465	15	5	conducting	conduct	VERB
admet-1465	15	6	ivr	ivr	NOUN
admet-1465	15	7	tests	test	NOUN
admet-1465	15	8	are	be	AUX
admet-1465	15	9	described	describe	VERB
admet-1465	15	10	in	in	ADP
admet-1465	15	11	the	the	DET
admet-1465	15	12	united	united	PROPN
admet-1465	15	13	states	states	PROPN
admet-1465	15	14	pharmacopoeia	pharmacopoeia	PROPN
admet-1465	15	15	(	(	PUNCT
admet-1465	15	16	usp	usp	PROPN
admet-1465	15	17	)	)	PUNCT
admet-1465	15	18	,	,	PUNCT
admet-1465	15	19	european	european	ADJ
admet-1465	15	20	pharmacopoeia	pharmacopoeia	PROPN
admet-1465	15	21	(	(	PUNCT
admet-1465	15	22	ph	ph	PROPN
admet-1465	15	23	.	.	PROPN
admet-1465	15	24	eur	eur	PROPN
admet-1465	15	25	.	.	PUNCT
admet-1465	15	26	)	)	PUNCT
admet-1465	16	1	and	and	CCONJ
admet-1465	16	2	japanese	japanese	ADJ
admet-1465	16	3	pharmacopoeia	pharmacopoeia	NOUN
admet-1465	16	4	(	(	PUNCT
admet-1465	16	5	jp	jp	NOUN
admet-1465	16	6	)	)	PUNCT
admet-1465	16	7	,	,	PUNCT
admet-1465	16	8	but	but	CCONJ
admet-1465	16	9	their	their	PRON
admet-1465	16	10	application	application	NOUN
admet-1465	16	11	is	be	AUX
admet-1465	16	12	mostly	mostly	ADV
admet-1465	16	13	limited	limit	VERB
admet-1465	16	14	to	to	PART
admet-1465	16	15	orally	orally	ADV
admet-1465	16	16	administered	administer	VERB
admet-1465	16	17	drug	drug	NOUN
admet-1465	16	18	products	product	NOUN
admet-1465	16	19	and	and	CCONJ
admet-1465	16	20	transdermal	transdermal	ADJ
admet-1465	16	21	patches	patch	NOUN
admet-1465	16	22	.	.	PUNCT
admet-1465	17	1	to	to	ADP
admet-1465	17	2	date	date	NOUN
admet-1465	17	3	,	,	PUNCT
admet-1465	17	4	no	no	DET
admet-1465	17	5	standardised	standardised	ADJ
admet-1465	17	6	ivr	ivr	NOUN
admet-1465	17	7	test	test	NOUN
admet-1465	17	8	for	for	ADP
admet-1465	17	9	the	the	DET
admet-1465	17	10	parenteral	parenteral	ADJ
admet-1465	17	11	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	NOUN
admet-1465	17	12	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	17	13	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1465	17	14	mailto:biserka.cetina-cizmek@pliva.com	mailto:biserka.cetina-cizmek@pliva.com	PROPN
admet-1465	17	15	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1465	17	16	filip	filip	PROPN
admet-1465	17	17	kozlina	kozlina	PROPN
admet-1465	17	18	et	et	PROPN
admet-1465	17	19	al	al	PROPN
admet-1465	17	20	.	.	PROPN
admet-1465	17	21	admet	admet	PROPN
admet-1465	17	22	&	&	CCONJ
admet-1465	17	23	dmpk	dmpk	PROPN
admet-1465	17	24	10(4	10(4	NUM
admet-1465	17	25	)	)	PUNCT
admet-1465	17	26	(	(	PUNCT
admet-1465	17	27	2022	2022	NUM
admet-1465	17	28	)	)	PUNCT
admet-1465	17	29	315	315	NUM
admet-1465	17	30	-	-	SYM
admet-1465	17	31	329	329	NUM
admet-1465	17	32	316	316	NUM
admet-1465	17	33	products	product	NOUN
admet-1465	17	34	is	be	AUX
admet-1465	17	35	available	available	ADJ
admet-1465	17	36	,	,	PUNCT
admet-1465	17	37	which	which	PRON
admet-1465	17	38	makes	make	VERB
admet-1465	17	39	the	the	DET
admet-1465	17	40	development	development	NOUN
admet-1465	17	41	of	of	ADP
admet-1465	17	42	such	such	ADJ
admet-1465	17	43	methods	method	NOUN
admet-1465	17	44	an	an	DET
admet-1465	17	45	enduring	endure	VERB
admet-1465	17	46	challenge	challenge	NOUN
admet-1465	17	47	[	[	X
admet-1465	17	48	5,6	5,6	NUM
admet-1465	17	49	]	]	X
admet-1465	17	50	.	.	PUNCT
admet-1465	18	1	oil	oil	NOUN
admet-1465	18	2	solutions	solution	NOUN
admet-1465	18	3	are	be	AUX
admet-1465	18	4	a	a	DET
admet-1465	18	5	type	type	NOUN
admet-1465	18	6	of	of	ADP
admet-1465	18	7	prolonged	prolonged	ADJ
admet-1465	18	8	-	-	PUNCT
admet-1465	18	9	release	release	NOUN
admet-1465	18	10	dosage	dosage	NOUN
admet-1465	18	11	form	form	NOUN
admet-1465	18	12	that	that	PRON
admet-1465	18	13	allows	allow	VERB
admet-1465	18	14	parenteral	parenteral	ADJ
admet-1465	18	15	administration	administration	NOUN
admet-1465	18	16	of	of	ADP
admet-1465	18	17	poorly	poorly	ADV
admet-1465	18	18	soluble	soluble	ADJ
admet-1465	18	19	drugs	drug	NOUN
admet-1465	18	20	or	or	CCONJ
admet-1465	18	21	unstable	unstable	ADJ
admet-1465	18	22	in	in	ADP
admet-1465	18	23	aqueous	aqueous	ADJ
admet-1465	18	24	systems	system	NOUN
admet-1465	18	25	[	[	X
admet-1465	18	26	7	7	NUM
admet-1465	18	27	]	]	PUNCT
admet-1465	18	28	.	.	PUNCT
admet-1465	19	1	vegetable	vegetable	ADJ
admet-1465	19	2	oils	oil	NOUN
admet-1465	19	3	(	(	PUNCT
admet-1465	19	4	such	such	ADJ
admet-1465	19	5	as	as	ADP
admet-1465	19	6	castor	castor	NOUN
admet-1465	19	7	,	,	PUNCT
admet-1465	19	8	sesame	sesame	NOUN
admet-1465	19	9	,	,	PUNCT
admet-1465	19	10	cottonseed	cottonseed	NOUN
admet-1465	19	11	,	,	PUNCT
admet-1465	19	12	etc	etc	X
admet-1465	19	13	.	.	X
admet-1465	19	14	)	)	PUNCT
admet-1465	19	15	,	,	PUNCT
admet-1465	19	16	medium	medium	NOUN
admet-1465	19	17	chain	chain	NOUN
admet-1465	19	18	triglycerides	triglyceride	NOUN
admet-1465	19	19	and	and	CCONJ
admet-1465	19	20	fatty	fatty	NOUN
admet-1465	19	21	acid	acid	NOUN
admet-1465	19	22	monoesters	monoester	NOUN
admet-1465	19	23	,	,	PUNCT
admet-1465	19	24	or	or	CCONJ
admet-1465	19	25	their	their	PRON
admet-1465	19	26	mixtures	mixture	NOUN
admet-1465	19	27	normally	normally	ADV
admet-1465	19	28	play	play	VERB
admet-1465	19	29	the	the	DET
admet-1465	19	30	role	role	NOUN
admet-1465	19	31	of	of	ADP
admet-1465	19	32	a	a	DET
admet-1465	19	33	solvent	solvent	NOUN
admet-1465	19	34	in	in	ADP
admet-1465	19	35	these	these	DET
admet-1465	19	36	products	product	NOUN
admet-1465	19	37	[	[	X
admet-1465	19	38	8	8	NUM
admet-1465	19	39	]	]	PUNCT
admet-1465	19	40	.	.	PUNCT
admet-1465	20	1	following	follow	VERB
admet-1465	20	2	their	their	PRON
admet-1465	20	3	application	application	NOUN
admet-1465	20	4	(	(	PUNCT
admet-1465	20	5	usually	usually	ADV
admet-1465	20	6	intramuscular	intramuscular	ADJ
admet-1465	20	7	)	)	PUNCT
admet-1465	20	8	,	,	PUNCT
admet-1465	20	9	the	the	DET
admet-1465	20	10	oil	oil	NOUN
admet-1465	20	11	forms	form	VERB
admet-1465	20	12	a	a	DET
admet-1465	20	13	depot	depot	NOUN
admet-1465	20	14	,	,	PUNCT
admet-1465	20	15	from	from	ADP
admet-1465	20	16	which	which	PRON
admet-1465	20	17	a	a	DET
admet-1465	20	18	prolonged	prolonged	ADJ
admet-1465	20	19	drug	drug	NOUN
admet-1465	20	20	release	release	NOUN
admet-1465	20	21	(	(	PUNCT
admet-1465	20	22	and	and	CCONJ
admet-1465	20	23	some	some	DET
admet-1465	20	24	excipients	excipient	NOUN
admet-1465	20	25	)	)	PUNCT
admet-1465	20	26	occurs	occur	VERB
admet-1465	20	27	.	.	PUNCT
admet-1465	21	1	the	the	DET
admet-1465	21	2	prolonged	prolong	VERB
admet-1465	21	3	drug	drug	NOUN
admet-1465	21	4	release	release	NOUN
admet-1465	21	5	allows	allow	VERB
admet-1465	21	6	for	for	ADP
admet-1465	21	7	a	a	DET
admet-1465	21	8	significantly	significantly	ADV
admet-1465	21	9	less	less	ADV
admet-1465	21	10	frequent	frequent	ADJ
admet-1465	21	11	application	application	NOUN
admet-1465	21	12	,	,	PUNCT
admet-1465	21	13	making	make	VERB
admet-1465	21	14	oil	oil	NOUN
admet-1465	21	15	solutions	solution	NOUN
admet-1465	21	16	especially	especially	ADV
admet-1465	21	17	suitable	suitable	ADJ
admet-1465	21	18	for	for	ADP
admet-1465	21	19	the	the	DET
admet-1465	21	20	treatment	treatment	NOUN
admet-1465	21	21	of	of	ADP
admet-1465	21	22	chronic	chronic	ADJ
admet-1465	21	23	diseases	disease	NOUN
admet-1465	21	24	(	(	PUNCT
admet-1465	21	25	such	such	ADJ
admet-1465	21	26	as	as	ADP
admet-1465	21	27	hypogonadism	hypogonadism	NOUN
admet-1465	21	28	)	)	PUNCT
admet-1465	21	29	,	,	PUNCT
admet-1465	21	30	as	as	ADV
admet-1465	21	31	well	well	ADV
admet-1465	21	32	as	as	ADP
admet-1465	21	33	diseases	disease	NOUN
admet-1465	21	34	characterised	characterise	VERB
admet-1465	21	35	by	by	ADP
admet-1465	21	36	variable	variable	ADJ
admet-1465	21	37	patient	patient	ADJ
admet-1465	21	38	adherence	adherence	NOUN
admet-1465	21	39	(	(	PUNCT
admet-1465	21	40	e.g.	e.g.	ADV
admet-1465	21	41	schizophrenia	schizophrenia	NOUN
admet-1465	21	42	)	)	PUNCT
admet-1465	22	1	[	[	X
admet-1465	22	2	9,10	9,10	NUM
admet-1465	22	3	]	]	PUNCT
admet-1465	22	4	.	.	PUNCT
admet-1465	23	1	when	when	SCONJ
admet-1465	23	2	developing	develop	VERB
admet-1465	23	3	an	an	DET
admet-1465	23	4	oil	oil	NOUN
admet-1465	23	5	solution	solution	NOUN
admet-1465	23	6	,	,	PUNCT
admet-1465	23	7	the	the	DET
admet-1465	23	8	key	key	ADJ
admet-1465	23	9	points	point	NOUN
admet-1465	23	10	to	to	PART
admet-1465	23	11	think	think	VERB
admet-1465	23	12	of	of	ADP
admet-1465	23	13	are	be	AUX
admet-1465	23	14	the	the	DET
admet-1465	23	15	solubility	solubility	NOUN
admet-1465	23	16	of	of	ADP
admet-1465	23	17	the	the	DET
admet-1465	23	18	drug	drug	NOUN
admet-1465	23	19	in	in	ADP
admet-1465	23	20	the	the	DET
admet-1465	23	21	lipophilic	lipophilic	ADJ
admet-1465	23	22	vehicle	vehicle	NOUN
admet-1465	23	23	,	,	PUNCT
admet-1465	23	24	its	its	PRON
admet-1465	23	25	viscosity	viscosity	NOUN
admet-1465	23	26	,	,	PUNCT
admet-1465	23	27	and	and	CCONJ
admet-1465	23	28	the	the	DET
admet-1465	23	29	partitioning	partitioning	NOUN
admet-1465	23	30	of	of	ADP
admet-1465	23	31	the	the	DET
admet-1465	23	32	drug	drug	NOUN
admet-1465	23	33	between	between	ADP
admet-1465	23	34	the	the	DET
admet-1465	23	35	oil	oil	NOUN
admet-1465	23	36	and	and	CCONJ
admet-1465	23	37	the	the	DET
admet-1465	23	38	aqueous	aqueous	ADJ
admet-1465	23	39	phase	phase	NOUN
admet-1465	23	40	.	.	PUNCT
admet-1465	24	1	by	by	ADP
admet-1465	24	2	increasing	increase	VERB
admet-1465	24	3	the	the	DET
admet-1465	24	4	solubility	solubility	NOUN
admet-1465	24	5	of	of	ADP
admet-1465	24	6	the	the	DET
admet-1465	24	7	drug	drug	NOUN
admet-1465	24	8	,	,	PUNCT
admet-1465	24	9	a	a	DET
admet-1465	24	10	higher	high	ADJ
admet-1465	24	11	concentration	concentration	NOUN
admet-1465	24	12	of	of	ADP
admet-1465	24	13	the	the	DET
admet-1465	24	14	drug	drug	NOUN
admet-1465	24	15	in	in	ADP
admet-1465	24	16	the	the	DET
admet-1465	24	17	solution	solution	NOUN
admet-1465	24	18	is	be	AUX
admet-1465	24	19	allowed	allow	VERB
admet-1465	24	20	,	,	PUNCT
admet-1465	24	21	and	and	CCONJ
admet-1465	24	22	thereby	thereby	ADV
admet-1465	24	23	administration	administration	NOUN
admet-1465	24	24	of	of	ADP
admet-1465	24	25	a	a	DET
admet-1465	24	26	lower	low	ADJ
admet-1465	24	27	volume	volume	NOUN
admet-1465	24	28	of	of	ADP
admet-1465	24	29	the	the	DET
admet-1465	24	30	such	such	ADJ
admet-1465	24	31	drug	drug	NOUN
admet-1465	24	32	product	product	NOUN
admet-1465	24	33	.	.	PUNCT
admet-1465	25	1	this	this	PRON
admet-1465	25	2	resolves	resolve	VERB
admet-1465	25	3	some	some	PRON
admet-1465	25	4	of	of	ADP
admet-1465	25	5	the	the	DET
admet-1465	25	6	possible	possible	ADJ
admet-1465	25	7	major	major	ADJ
admet-1465	25	8	issues	issue	NOUN
admet-1465	25	9	regarding	regard	VERB
admet-1465	25	10	this	this	DET
admet-1465	25	11	type	type	NOUN
admet-1465	25	12	of	of	ADP
admet-1465	25	13	formulation	formulation	NOUN
admet-1465	25	14	,	,	PUNCT
admet-1465	25	15	including	include	VERB
admet-1465	25	16	pain	pain	NOUN
admet-1465	25	17	and	and	CCONJ
admet-1465	25	18	irritation	irritation	NOUN
admet-1465	25	19	at	at	ADP
admet-1465	25	20	the	the	DET
admet-1465	25	21	injection	injection	NOUN
admet-1465	25	22	site	site	NOUN
admet-1465	25	23	.	.	PUNCT
admet-1465	26	1	solubility	solubility	NOUN
admet-1465	26	2	of	of	ADP
admet-1465	26	3	the	the	DET
admet-1465	26	4	drug	drug	NOUN
admet-1465	26	5	is	be	AUX
admet-1465	26	6	most	most	ADV
admet-1465	26	7	often	often	ADV
admet-1465	26	8	increased	increase	VERB
admet-1465	26	9	using	use	VERB
admet-1465	26	10	cosolvents	cosolvent	NOUN
admet-1465	26	11	,	,	PUNCT
admet-1465	26	12	usually	usually	ADV
admet-1465	26	13	,	,	PUNCT
admet-1465	26	14	alcohols	alcohol	NOUN
admet-1465	26	15	or	or	CCONJ
admet-1465	26	16	simple	simple	ADJ
admet-1465	26	17	esters	ester	NOUN
admet-1465	26	18	,	,	PUNCT
admet-1465	26	19	whose	whose	DET
admet-1465	26	20	addition	addition	NOUN
admet-1465	26	21	simultaneously	simultaneously	ADV
admet-1465	26	22	decreases	decrease	VERB
admet-1465	26	23	the	the	DET
admet-1465	26	24	viscosity	viscosity	NOUN
admet-1465	26	25	of	of	ADP
admet-1465	26	26	the	the	DET
admet-1465	26	27	solution	solution	NOUN
admet-1465	26	28	,	,	PUNCT
admet-1465	26	29	making	make	VERB
admet-1465	26	30	it	it	PRON
admet-1465	26	31	easier	easy	ADJ
admet-1465	26	32	to	to	PART
admet-1465	26	33	flow	flow	VERB
admet-1465	26	34	through	through	ADP
admet-1465	26	35	a	a	DET
admet-1465	26	36	hypodermic	hypodermic	ADJ
admet-1465	26	37	needle	needle	NOUN
admet-1465	26	38	(	(	PUNCT
admet-1465	26	39	raising	raise	VERB
admet-1465	26	40	the	the	DET
admet-1465	26	41	syringeability	syringeability	NOUN
admet-1465	26	42	of	of	ADP
admet-1465	26	43	the	the	DET
admet-1465	26	44	solution	solution	NOUN
admet-1465	26	45	)	)	PUNCT
admet-1465	26	46	.	.	PUNCT
admet-1465	27	1	however	however	ADV
admet-1465	27	2	,	,	PUNCT
admet-1465	27	3	these	these	DET
admet-1465	27	4	cosolvents	cosolvent	NOUN
admet-1465	27	5	allow	allow	VERB
admet-1465	27	6	higher	high	ADJ
admet-1465	27	7	partitioning	partitioning	NOUN
admet-1465	27	8	of	of	ADP
admet-1465	27	9	the	the	DET
admet-1465	27	10	drug	drug	NOUN
admet-1465	27	11	into	into	ADP
admet-1465	27	12	the	the	DET
admet-1465	27	13	aqueous	aqueous	ADJ
admet-1465	27	14	phase	phase	NOUN
admet-1465	27	15	,	,	PUNCT
admet-1465	27	16	which	which	PRON
admet-1465	27	17	might	might	AUX
admet-1465	27	18	shorten	shorten	VERB
admet-1465	27	19	the	the	DET
admet-1465	27	20	release	release	NOUN
admet-1465	27	21	time	time	NOUN
admet-1465	27	22	of	of	ADP
admet-1465	27	23	the	the	DET
admet-1465	27	24	drug	drug	NOUN
admet-1465	27	25	,	,	PUNCT
admet-1465	27	26	thus	thus	ADV
admet-1465	27	27	decreasing	decrease	VERB
admet-1465	27	28	its	its	PRON
admet-1465	27	29	value	value	NOUN
admet-1465	27	30	as	as	ADP
admet-1465	27	31	a	a	DET
admet-1465	27	32	sustained	sustained	ADJ
admet-1465	27	33	release	release	NOUN
admet-1465	27	34	formulation	formulation	NOUN
admet-1465	27	35	.	.	PUNCT
admet-1465	28	1	therefore	therefore	ADV
admet-1465	28	2	,	,	PUNCT
admet-1465	28	3	the	the	DET
admet-1465	28	4	amount	amount	NOUN
admet-1465	28	5	of	of	ADP
admet-1465	28	6	cosolvent	cosolvent	NOUN
admet-1465	28	7	added	add	VERB
admet-1465	28	8	to	to	ADP
admet-1465	28	9	the	the	DET
admet-1465	28	10	solution	solution	NOUN
admet-1465	28	11	must	must	AUX
admet-1465	28	12	be	be	AUX
admet-1465	28	13	carefully	carefully	ADV
admet-1465	28	14	determined	determine	VERB
admet-1465	28	15	in	in	ADP
admet-1465	28	16	order	order	NOUN
admet-1465	28	17	to	to	PART
admet-1465	28	18	balance	balance	VERB
admet-1465	28	19	out	out	ADP
admet-1465	28	20	its	its	PRON
admet-1465	28	21	positive	positive	ADJ
admet-1465	28	22	effects	effect	NOUN
admet-1465	28	23	on	on	ADP
admet-1465	28	24	drug	drug	NOUN
admet-1465	28	25	solubility	solubility	NOUN
admet-1465	28	26	and	and	CCONJ
admet-1465	28	27	solution	solution	NOUN
admet-1465	28	28	viscosity	viscosity	NOUN
admet-1465	28	29	while	while	SCONJ
admet-1465	28	30	maintaining	maintain	VERB
admet-1465	28	31	the	the	DET
admet-1465	28	32	partitioning	partitioning	NOUN
admet-1465	28	33	of	of	ADP
admet-1465	28	34	the	the	DET
admet-1465	28	35	drug	drug	NOUN
admet-1465	28	36	adequate	adequate	ADJ
admet-1465	28	37	for	for	ADP
admet-1465	28	38	prolonged	prolonged	ADJ
admet-1465	28	39	drug	drug	NOUN
admet-1465	28	40	release	release	NOUN
admet-1465	28	41	[	[	X
admet-1465	28	42	8	8	NUM
admet-1465	28	43	]	]	PUNCT
admet-1465	28	44	.	.	PUNCT
admet-1465	29	1	dexamethasone	dexamethasone	NOUN
admet-1465	29	2	(	(	PUNCT
admet-1465	29	3	dex	dex	NOUN
admet-1465	29	4	)	)	PUNCT
admet-1465	29	5	is	be	AUX
admet-1465	29	6	a	a	DET
admet-1465	29	7	highly	highly	ADV
admet-1465	29	8	potent	potent	ADJ
admet-1465	29	9	glucocorticoid	glucocorticoid	NOUN
admet-1465	29	10	used	use	VERB
admet-1465	29	11	in	in	ADP
admet-1465	29	12	the	the	DET
admet-1465	29	13	treatment	treatment	NOUN
admet-1465	29	14	of	of	ADP
admet-1465	29	15	multiple	multiple	ADJ
admet-1465	29	16	conditions	condition	NOUN
admet-1465	29	17	characterised	characterise	VERB
admet-1465	29	18	by	by	ADP
admet-1465	29	19	severe	severe	ADJ
admet-1465	29	20	inflammation	inflammation	NOUN
admet-1465	29	21	,	,	PUNCT
admet-1465	29	22	e.g.	e.g.	ADV
admet-1465	29	23	,	,	PUNCT
admet-1465	29	24	rheumatoid	rheumatoid	NOUN
admet-1465	29	25	arthritis	arthritis	NOUN
admet-1465	29	26	.	.	PUNCT
admet-1465	30	1	dex	dex	NOUN
admet-1465	30	2	is	be	AUX
admet-1465	30	3	a	a	DET
admet-1465	30	4	moderately	moderately	ADV
admet-1465	30	5	lipophilic	lipophilic	ADJ
admet-1465	30	6	molecule	molecule	NOUN
admet-1465	30	7	with	with	ADP
admet-1465	30	8	a	a	DET
admet-1465	30	9	log	log	NOUN
admet-1465	30	10	p	p	NOUN
admet-1465	30	11	of	of	ADP
admet-1465	30	12	1.68	1.68	NUM
admet-1465	30	13	,	,	PUNCT
admet-1465	30	14	practically	practically	ADV
admet-1465	30	15	insoluble	insoluble	ADJ
admet-1465	30	16	in	in	ADP
admet-1465	30	17	water	water	NOUN
admet-1465	30	18	and	and	CCONJ
admet-1465	30	19	sparingly	sparingly	ADV
admet-1465	30	20	soluble	soluble	ADJ
admet-1465	30	21	in	in	ADP
admet-1465	30	22	ethanol	ethanol	NOUN
admet-1465	30	23	.	.	PUNCT
admet-1465	31	1	its	its	PRON
admet-1465	31	2	most	most	ADV
admet-1465	31	3	acidic	acidic	ADJ
admet-1465	31	4	group	group	NOUN
admet-1465	31	5	has	have	VERB
admet-1465	31	6	a	a	DET
admet-1465	31	7	pka	pka	NOUN
admet-1465	31	8	value	value	NOUN
admet-1465	31	9	of	of	ADP
admet-1465	31	10	12.42	12.42	NUM
admet-1465	31	11	,	,	PUNCT
admet-1465	31	12	meaning	mean	VERB
admet-1465	31	13	it	it	PRON
admet-1465	31	14	is	be	AUX
admet-1465	31	15	a	a	DET
admet-1465	31	16	neutral	neutral	ADJ
admet-1465	31	17	molecule	molecule	NOUN
admet-1465	31	18	within	within	ADP
admet-1465	31	19	the	the	DET
admet-1465	31	20	physiological	physiological	ADJ
admet-1465	31	21	ph	ph	NOUN
admet-1465	31	22	range	range	NOUN
admet-1465	31	23	[	[	X
admet-1465	31	24	11	11	NUM
admet-1465	31	25	]	]	PUNCT
admet-1465	31	26	.	.	PUNCT
admet-1465	32	1	oil	oil	NOUN
admet-1465	32	2	solution	solution	NOUN
admet-1465	32	3	-	-	PUNCT
admet-1465	32	4	based	base	VERB
admet-1465	32	5	drug	drug	NOUN
admet-1465	32	6	products	product	NOUN
admet-1465	32	7	containing	contain	VERB
admet-1465	32	8	dex	dex	NOUN
admet-1465	32	9	have	have	AUX
admet-1465	32	10	been	be	AUX
admet-1465	32	11	investigated	investigate	VERB
admet-1465	32	12	in	in	ADP
admet-1465	32	13	several	several	ADJ
admet-1465	32	14	studies	study	NOUN
admet-1465	32	15	so	so	ADV
admet-1465	32	16	far	far	ADV
admet-1465	32	17	[	[	X
admet-1465	32	18	12,13	12,13	NUM
admet-1465	32	19	]	]	PUNCT
admet-1465	32	20	,	,	PUNCT
admet-1465	32	21	as	as	SCONJ
admet-1465	32	22	such	such	ADJ
admet-1465	32	23	setup	setup	NOUN
admet-1465	32	24	might	might	AUX
admet-1465	32	25	prove	prove	VERB
admet-1465	32	26	useful	useful	ADJ
admet-1465	32	27	in	in	ADP
admet-1465	32	28	the	the	DET
admet-1465	32	29	treatment	treatment	NOUN
admet-1465	32	30	of	of	ADP
admet-1465	32	31	inflammatory	inflammatory	ADJ
admet-1465	32	32	diseases	disease	NOUN
admet-1465	32	33	due	due	ADP
admet-1465	32	34	to	to	ADP
admet-1465	32	35	its	its	PRON
admet-1465	32	36	potential	potential	ADJ
admet-1465	32	37	prolonged	prolonged	ADJ
admet-1465	32	38	release	release	NOUN
admet-1465	32	39	.	.	PUNCT
admet-1465	33	1	furthermore	furthermore	ADV
admet-1465	33	2	,	,	PUNCT
admet-1465	33	3	such	such	DET
admet-1465	33	4	a	a	DET
admet-1465	33	5	solution	solution	NOUN
admet-1465	33	6	,	,	PUNCT
admet-1465	33	7	applied	apply	VERB
admet-1465	33	8	locally	locally	ADV
admet-1465	33	9	,	,	PUNCT
admet-1465	33	10	should	should	AUX
admet-1465	33	11	pose	pose	VERB
admet-1465	33	12	less	less	ADJ
admet-1465	33	13	of	of	ADP
admet-1465	33	14	a	a	DET
admet-1465	33	15	risk	risk	NOUN
admet-1465	33	16	due	due	ADP
admet-1465	33	17	to	to	ADP
admet-1465	33	18	drug	drug	NOUN
admet-1465	33	19	systemic	systemic	ADJ
admet-1465	33	20	exposure	exposure	NOUN
admet-1465	33	21	.	.	PUNCT
admet-1465	34	1	considering	consider	VERB
admet-1465	34	2	the	the	DET
admet-1465	34	3	fact	fact	NOUN
admet-1465	34	4	that	that	SCONJ
admet-1465	34	5	dex	dex	NOUN
admet-1465	34	6	contains	contain	VERB
admet-1465	34	7	a	a	DET
admet-1465	34	8	chromophore	chromophore	NOUN
admet-1465	34	9	,	,	PUNCT
admet-1465	34	10	its	its	PRON
admet-1465	34	11	content	content	NOUN
admet-1465	34	12	can	can	AUX
admet-1465	34	13	be	be	AUX
admet-1465	34	14	determined	determine	VERB
admet-1465	34	15	via	via	ADP
admet-1465	34	16	uv	uv	NOUN
admet-1465	34	17	-	-	PUNCT
admet-1465	34	18	vis	vis	X
admet-1465	34	19	spectrometry	spectrometry	NOUN
admet-1465	34	20	.	.	PUNCT
admet-1465	35	1	analysis	analysis	NOUN
admet-1465	35	2	on	on	ADP
admet-1465	35	3	the	the	DET
admet-1465	35	4	standard	standard	ADJ
admet-1465	35	5	usp	usp	PROPN
admet-1465	35	6	ii	ii	PROPN
admet-1465	35	7	dissolution	dissolution	NOUN
admet-1465	35	8	system	system	NOUN
admet-1465	35	9	requires	require	VERB
admet-1465	35	10	sampling	sample	VERB
admet-1465	35	11	the	the	DET
admet-1465	35	12	medium	medium	NOUN
admet-1465	35	13	at	at	ADP
admet-1465	35	14	desired	desire	VERB
admet-1465	35	15	time	time	NOUN
admet-1465	35	16	points	point	NOUN
admet-1465	35	17	,	,	PUNCT
admet-1465	35	18	followed	follow	VERB
admet-1465	35	19	by	by	ADP
admet-1465	35	20	filtration	filtration	NOUN
admet-1465	35	21	and	and	CCONJ
admet-1465	35	22	further	further	ADJ
admet-1465	35	23	analysis	analysis	NOUN
admet-1465	35	24	.	.	PUNCT
admet-1465	36	1	sample	sample	NOUN
admet-1465	36	2	analysis	analysis	NOUN
admet-1465	36	3	can	can	AUX
admet-1465	36	4	be	be	AUX
admet-1465	36	5	a	a	DET
admet-1465	36	6	significant	significant	ADJ
admet-1465	36	7	drawback	drawback	NOUN
admet-1465	36	8	in	in	ADP
admet-1465	36	9	time	time	NOUN
admet-1465	36	10	and	and	CCONJ
admet-1465	36	11	resources	resource	NOUN
admet-1465	36	12	if	if	SCONJ
admet-1465	36	13	performed	perform	VERB
admet-1465	36	14	by	by	ADP
admet-1465	36	15	hplc	hplc	NOUN
admet-1465	36	16	analysis	analysis	NOUN
admet-1465	36	17	.	.	PUNCT
admet-1465	37	1	on	on	ADP
admet-1465	37	2	the	the	DET
admet-1465	37	3	other	other	ADJ
admet-1465	37	4	hand	hand	NOUN
admet-1465	37	5	,	,	PUNCT
admet-1465	37	6	an	an	DET
admet-1465	37	7	online	online	ADJ
admet-1465	37	8	uv	uv	NOUN
admet-1465	37	9	-	-	PUNCT
admet-1465	37	10	vis	vis	X
admet-1465	37	11	spectrometer	spectrometer	NOUN
admet-1465	37	12	coupled	couple	VERB
admet-1465	37	13	with	with	ADP
admet-1465	37	14	a	a	DET
admet-1465	37	15	dissolution	dissolution	NOUN
admet-1465	37	16	system	system	NOUN
admet-1465	37	17	significantly	significantly	ADV
admet-1465	37	18	decreases	decrease	VERB
admet-1465	37	19	the	the	DET
admet-1465	37	20	time	time	NOUN
admet-1465	37	21	needed	need	VERB
admet-1465	37	22	for	for	ADP
admet-1465	37	23	obtaining	obtain	VERB
admet-1465	37	24	drug	drug	NOUN
admet-1465	37	25	release	release	NOUN
admet-1465	37	26	profile	profile	NOUN
admet-1465	37	27	curves	curve	NOUN
admet-1465	37	28	.	.	PUNCT
admet-1465	38	1	the	the	DET
admet-1465	38	2	use	use	NOUN
admet-1465	38	3	of	of	ADP
admet-1465	38	4	a	a	DET
admet-1465	38	5	fiber	fiber	NOUN
admet-1465	38	6	optic	optic	NOUN
admet-1465	38	7	automated	automate	VERB
admet-1465	38	8	dissolution	dissolution	NOUN
admet-1465	38	9	system	system	NOUN
admet-1465	38	10	has	have	VERB
admet-1465	38	11	many	many	ADJ
admet-1465	38	12	advantages	advantage	NOUN
admet-1465	38	13	compared	compare	VERB
admet-1465	38	14	to	to	ADP
admet-1465	38	15	both	both	PRON
admet-1465	38	16	of	of	ADP
admet-1465	38	17	these	these	DET
admet-1465	38	18	options	option	NOUN
admet-1465	38	19	.	.	PUNCT
admet-1465	39	1	fiber	fiber	NOUN
admet-1465	39	2	optic	optic	NOUN
admet-1465	39	3	probes	probe	NOUN
admet-1465	39	4	connected	connect	VERB
admet-1465	39	5	to	to	ADP
admet-1465	39	6	a	a	DET
admet-1465	39	7	uv	uv	NOUN
admet-1465	39	8	-	-	PUNCT
admet-1465	39	9	vis	vis	X
admet-1465	39	10	spectrometer	spectrometer	NOUN
admet-1465	39	11	are	be	AUX
admet-1465	39	12	immersed	immerse	VERB
admet-1465	39	13	into	into	ADP
admet-1465	39	14	the	the	DET
admet-1465	39	15	release	release	NOUN
admet-1465	39	16	medium	medium	NOUN
admet-1465	39	17	throughout	throughout	ADP
admet-1465	39	18	the	the	DET
admet-1465	39	19	entire	entire	ADJ
admet-1465	39	20	experiment	experiment	NOUN
admet-1465	39	21	,	,	PUNCT
admet-1465	39	22	thus	thus	ADV
admet-1465	39	23	not	not	PART
admet-1465	39	24	requiring	require	VERB
admet-1465	39	25	additional	additional	ADJ
admet-1465	39	26	medium	medium	ADJ
admet-1465	39	27	sampling	sampling	NOUN
admet-1465	39	28	at	at	ADP
admet-1465	39	29	desired	desire	VERB
admet-1465	39	30	time	time	NOUN
admet-1465	39	31	points	point	NOUN
admet-1465	39	32	and	and	CCONJ
admet-1465	39	33	concurrent	concurrent	ADJ
admet-1465	39	34	replacement	replacement	NOUN
admet-1465	39	35	of	of	ADP
admet-1465	39	36	the	the	DET
admet-1465	39	37	fresh	fresh	ADJ
admet-1465	39	38	medium	medium	NOUN
admet-1465	39	39	.	.	PUNCT
admet-1465	40	1	this	this	DET
admet-1465	40	2	results	result	VERB
admet-1465	40	3	in	in	ADP
admet-1465	40	4	significantly	significantly	ADV
admet-1465	40	5	lower	low	ADJ
admet-1465	40	6	consumption	consumption	NOUN
admet-1465	40	7	of	of	ADP
admet-1465	40	8	time	time	NOUN
admet-1465	40	9	and	and	CCONJ
admet-1465	40	10	materials	material	NOUN
admet-1465	40	11	,	,	PUNCT
admet-1465	40	12	such	such	ADJ
admet-1465	40	13	as	as	ADP
admet-1465	40	14	filters	filter	NOUN
admet-1465	40	15	,	,	PUNCT
admet-1465	40	16	pipettes	pipette	NOUN
admet-1465	40	17	,	,	PUNCT
admet-1465	40	18	or	or	CCONJ
admet-1465	40	19	tubing	tubing	NOUN
admet-1465	40	20	,	,	PUNCT
admet-1465	40	21	compared	compare	VERB
admet-1465	40	22	even	even	ADV
admet-1465	40	23	to	to	ADP
admet-1465	40	24	an	an	DET
admet-1465	40	25	online	online	ADJ
admet-1465	40	26	spectrometer	spectrometer	NOUN
admet-1465	40	27	detection	detection	NOUN
admet-1465	40	28	,	,	PUNCT
admet-1465	40	29	and	and	CCONJ
admet-1465	40	30	especially	especially	ADV
admet-1465	40	31	to	to	ADP
admet-1465	40	32	manual	manual	ADJ
admet-1465	40	33	sampling	sampling	NOUN
admet-1465	40	34	followed	follow	VERB
admet-1465	40	35	by	by	ADP
admet-1465	40	36	hplc	hplc	NOUN
admet-1465	40	37	analysis	analysis	NOUN
admet-1465	40	38	.	.	PUNCT
admet-1465	41	1	simplified	simplify	VERB
admet-1465	41	2	detection	detection	NOUN
admet-1465	41	3	also	also	ADV
admet-1465	41	4	decreases	decrease	VERB
admet-1465	41	5	the	the	DET
admet-1465	41	6	intervals	interval	NOUN
admet-1465	41	7	between	between	ADP
admet-1465	41	8	time	time	NOUN
admet-1465	41	9	points	point	NOUN
admet-1465	41	10	,	,	PUNCT
admet-1465	41	11	making	make	VERB
admet-1465	41	12	it	it	PRON
admet-1465	41	13	possible	possible	ADJ
admet-1465	41	14	to	to	PART
admet-1465	41	15	obtain	obtain	VERB
admet-1465	41	16	readouts	readout	NOUN
admet-1465	41	17	even	even	ADV
admet-1465	41	18	in	in	ADP
admet-1465	41	19	less	less	ADJ
admet-1465	41	20	than	than	ADP
admet-1465	41	21	a	a	DET
admet-1465	41	22	minute	minute	NOUN
admet-1465	41	23	intervals	interval	NOUN
admet-1465	41	24	if	if	SCONJ
admet-1465	41	25	desired	desire	VERB
admet-1465	41	26	.	.	PUNCT
admet-1465	42	1	finally	finally	ADV
admet-1465	42	2	,	,	PUNCT
admet-1465	42	3	in	in	ADP
admet-1465	42	4	-	-	PUNCT
admet-1465	42	5	situ	situ	ADJ
admet-1465	42	6	spectroscopic	spectroscopic	NOUN
admet-1465	42	7	detection	detection	NOUN
admet-1465	42	8	through	through	ADP
admet-1465	42	9	optic	optic	ADJ
admet-1465	42	10	probes	probe	NOUN
admet-1465	42	11	enables	enable	VERB
admet-1465	42	12	real	real	ADJ
admet-1465	42	13	-	-	PUNCT
admet-1465	42	14	time	time	NOUN
admet-1465	42	15	monitoring	monitoring	NOUN
admet-1465	42	16	of	of	ADP
admet-1465	42	17	drug	drug	NOUN
admet-1465	42	18	release	release	NOUN
admet-1465	42	19	during	during	ADP
admet-1465	42	20	the	the	DET
admet-1465	42	21	dissolution	dissolution	NOUN
admet-1465	42	22	process	process	NOUN
admet-1465	42	23	[	[	X
admet-1465	42	24	14	14	NUM
admet-1465	42	25	]	]	PUNCT
admet-1465	42	26	.	.	PUNCT
admet-1465	43	1	even	even	ADV
admet-1465	43	2	though	though	SCONJ
admet-1465	43	3	the	the	DET
admet-1465	43	4	probe	probe	NOUN
admet-1465	43	5	is	be	AUX
admet-1465	43	6	constantly	constantly	ADV
admet-1465	43	7	exposed	expose	VERB
admet-1465	43	8	to	to	ADP
admet-1465	43	9	room	room	NOUN
admet-1465	43	10	light	light	NOUN
admet-1465	43	11	(	(	PUNCT
admet-1465	43	12	unlike	unlike	ADP
admet-1465	43	13	conventional	conventional	ADJ
admet-1465	43	14	cuvettes	cuvette	NOUN
admet-1465	43	15	)	)	PUNCT
admet-1465	43	16	,	,	PUNCT
admet-1465	43	17	fiber	fiber	NOUN
admet-1465	43	18	optic	optic	NOUN
admet-1465	43	19	spectrometry	spectrometry	NOUN
admet-1465	43	20	has	have	AUX
admet-1465	43	21	so	so	ADV
admet-1465	43	22	far	far	ADV
admet-1465	43	23	proven	prove	VERB
admet-1465	43	24	to	to	PART
admet-1465	43	25	be	be	AUX
admet-1465	43	26	mostly	mostly	ADV
admet-1465	43	27	unaffected	unaffected	ADJ
admet-1465	43	28	by	by	ADP
admet-1465	43	29	this	this	DET
admet-1465	43	30	potential	potential	ADJ
admet-1465	43	31	interference	interference	NOUN
admet-1465	43	32	.	.	PUNCT
admet-1465	44	1	due	due	ADP
admet-1465	44	2	to	to	ADP
admet-1465	44	3	the	the	DET
admet-1465	44	4	lack	lack	NOUN
admet-1465	44	5	of	of	ADP
admet-1465	44	6	admet	admet	PROPN
admet-1465	44	7	&	&	CCONJ
admet-1465	44	8	dmpk	dmpk	PROPN
admet-1465	44	9	10(4	10(4	NUM
admet-1465	44	10	)	)	PUNCT
admet-1465	44	11	(	(	PUNCT
admet-1465	44	12	2022	2022	NUM
admet-1465	44	13	)	)	PUNCT
admet-1465	44	14	315	315	NUM
admet-1465	44	15	-	-	SYM
admet-1465	44	16	329	329	NUM
admet-1465	44	17	dexamethasone	dexamethasone	NOUN
admet-1465	44	18	release	release	NOUN
admet-1465	44	19	from	from	ADP
admet-1465	44	20	the	the	DET
admet-1465	44	21	oil	oil	NOUN
admet-1465	44	22	solutions	solution	NOUN
admet-1465	44	23	doi	doi	NOUN
admet-1465	44	24	:	:	PUNCT
admet-1465	44	25	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	NUM
admet-1465	44	26	317	317	NUM
admet-1465	44	27	release	release	NOUN
admet-1465	44	28	medium	medium	ADJ
admet-1465	44	29	filtration	filtration	NOUN
admet-1465	44	30	,	,	PUNCT
admet-1465	44	31	detection	detection	NOUN
admet-1465	44	32	can	can	AUX
admet-1465	44	33	be	be	AUX
admet-1465	44	34	compromised	compromise	VERB
admet-1465	44	35	by	by	ADP
admet-1465	44	36	the	the	DET
admet-1465	44	37	interference	interference	NOUN
admet-1465	44	38	of	of	ADP
admet-1465	44	39	unsolved	unsolved	ADJ
admet-1465	44	40	particles	particle	NOUN
admet-1465	44	41	or	or	CCONJ
admet-1465	44	42	excipients	excipient	NOUN
admet-1465	44	43	,	,	PUNCT
admet-1465	44	44	which	which	PRON
admet-1465	44	45	can	can	AUX
admet-1465	44	46	cause	cause	VERB
admet-1465	44	47	light	light	ADJ
admet-1465	44	48	scattering	scattering	NOUN
admet-1465	44	49	on	on	ADP
admet-1465	44	50	the	the	DET
admet-1465	44	51	optic	optic	ADJ
admet-1465	44	52	probes	probe	NOUN
admet-1465	44	53	[	[	X
admet-1465	44	54	14	14	NUM
admet-1465	44	55	]	]	PUNCT
admet-1465	44	56	.	.	PUNCT
admet-1465	45	1	these	these	DET
admet-1465	45	2	interferences	interference	NOUN
admet-1465	45	3	can	can	AUX
admet-1465	45	4	be	be	AUX
admet-1465	45	5	resolved	resolve	VERB
admet-1465	45	6	with	with	ADP
admet-1465	45	7	the	the	DET
admet-1465	45	8	use	use	NOUN
admet-1465	45	9	of	of	ADP
admet-1465	45	10	mathematical	mathematical	ADJ
admet-1465	45	11	filters	filter	NOUN
admet-1465	45	12	,	,	PUNCT
admet-1465	45	13	such	such	ADJ
admet-1465	45	14	as	as	ADP
admet-1465	45	15	baseline	baseline	ADJ
admet-1465	45	16	correction	correction	NOUN
admet-1465	45	17	or	or	CCONJ
admet-1465	45	18	derivative	derivative	ADJ
admet-1465	45	19	spectroscopy	spectroscopy	NOUN
admet-1465	45	20	[	[	X
admet-1465	45	21	15	15	NUM
admet-1465	45	22	]	]	PUNCT
admet-1465	45	23	,	,	PUNCT
admet-1465	45	24	as	as	SCONJ
admet-1465	45	25	demonstrated	demonstrate	VERB
admet-1465	45	26	in	in	ADP
admet-1465	45	27	this	this	DET
admet-1465	45	28	article	article	NOUN
admet-1465	45	29	.	.	PUNCT
admet-1465	46	1	in	in	ADP
admet-1465	46	2	addition	addition	NOUN
admet-1465	46	3	,	,	PUNCT
admet-1465	46	4	with	with	ADP
admet-1465	46	5	the	the	DET
admet-1465	46	6	use	use	NOUN
admet-1465	46	7	of	of	ADP
admet-1465	46	8	an	an	DET
admet-1465	46	9	appropriate	appropriate	ADJ
admet-1465	46	10	dialysis	dialysis	NOUN
admet-1465	46	11	bag	bag	NOUN
admet-1465	46	12	as	as	ADP
admet-1465	46	13	a	a	DET
admet-1465	46	14	sample	sample	NOUN
admet-1465	46	15	container	container	NOUN
admet-1465	46	16	,	,	PUNCT
admet-1465	46	17	possible	possible	ADJ
admet-1465	46	18	interferences	interference	NOUN
admet-1465	46	19	in	in	ADP
admet-1465	46	20	detection	detection	NOUN
admet-1465	46	21	can	can	AUX
admet-1465	46	22	be	be	AUX
admet-1465	46	23	minimized	minimize	VERB
admet-1465	46	24	or	or	CCONJ
admet-1465	46	25	totally	totally	ADV
admet-1465	46	26	diminished	diminish	VERB
admet-1465	46	27	.	.	PUNCT
admet-1465	47	1	some	some	DET
admet-1465	47	2	previous	previous	ADJ
admet-1465	47	3	attempts	attempt	NOUN
admet-1465	47	4	at	at	ADP
admet-1465	47	5	developing	develop	VERB
admet-1465	47	6	an	an	DET
admet-1465	47	7	ivr	ivr	NOUN
admet-1465	47	8	method	method	NOUN
admet-1465	47	9	for	for	SCONJ
admet-1465	47	10	oil	oil	NOUN
admet-1465	47	11	solutions	solution	NOUN
admet-1465	47	12	utilised	utilise	VERB
admet-1465	47	13	a	a	DET
admet-1465	47	14	dialysis	dialysis	NOUN
admet-1465	47	15	cell	cell	NOUN
admet-1465	47	16	model	model	NOUN
admet-1465	47	17	[	[	X
admet-1465	47	18	16,17	16,17	NUM
admet-1465	47	19	]	]	PUNCT
admet-1465	47	20	and	and	CCONJ
admet-1465	47	21	a	a	DET
admet-1465	47	22	simple	simple	ADJ
admet-1465	47	23	magnetic	magnetic	ADJ
admet-1465	47	24	stirrer	stirrer	ADJ
admet-1465	47	25	setup	setup	NOUN
admet-1465	47	26	with	with	ADP
admet-1465	47	27	the	the	DET
admet-1465	47	28	oil	oil	NOUN
admet-1465	47	29	formulation	formulation	NOUN
admet-1465	47	30	dispersed	disperse	VERB
admet-1465	47	31	in	in	ADP
admet-1465	47	32	a	a	DET
admet-1465	47	33	release	release	NOUN
admet-1465	47	34	medium	medium	NOUN
admet-1465	47	35	[	[	X
admet-1465	47	36	18	18	NUM
admet-1465	47	37	]	]	PUNCT
admet-1465	47	38	.	.	PUNCT
admet-1465	48	1	in	in	ADP
admet-1465	48	2	general	general	ADJ
admet-1465	48	3	,	,	PUNCT
admet-1465	48	4	the	the	DET
admet-1465	48	5	ivr	ivr	PROPN
admet-1465	48	6	methods	method	NOUN
admet-1465	48	7	for	for	ADP
admet-1465	48	8	oil	oil	NOUN
admet-1465	48	9	solutions	solution	NOUN
admet-1465	48	10	can	can	AUX
admet-1465	48	11	be	be	AUX
admet-1465	48	12	divided	divide	VERB
admet-1465	48	13	into	into	ADP
admet-1465	48	14	(	(	PUNCT
admet-1465	48	15	a	a	X
admet-1465	48	16	)	)	PUNCT
admet-1465	48	17	those	those	PRON
admet-1465	48	18	with	with	ADP
admet-1465	48	19	the	the	DET
admet-1465	48	20	oil	oil	NOUN
admet-1465	48	21	solution	solution	NOUN
admet-1465	48	22	floating	float	VERB
admet-1465	48	23	atop	atop	ADP
admet-1465	48	24	the	the	DET
admet-1465	48	25	release	release	NOUN
admet-1465	48	26	medium	medium	NOUN
admet-1465	48	27	,	,	PUNCT
admet-1465	48	28	(	(	PUNCT
admet-1465	48	29	b	b	X
admet-1465	48	30	)	)	PUNCT
admet-1465	48	31	dialysis	dialysis	NOUN
admet-1465	48	32	methods	method	NOUN
admet-1465	48	33	and	and	CCONJ
admet-1465	48	34	(	(	PUNCT
admet-1465	48	35	c	c	NOUN
admet-1465	48	36	)	)	PUNCT
admet-1465	48	37	continuous	continuous	ADJ
admet-1465	48	38	flow	flow	NOUN
admet-1465	48	39	methods	method	NOUN
admet-1465	48	40	.	.	PUNCT
admet-1465	49	1	all	all	DET
admet-1465	49	2	these	these	DET
admet-1465	49	3	approaches	approach	NOUN
admet-1465	49	4	share	share	VERB
admet-1465	49	5	some	some	PRON
admet-1465	49	6	of	of	ADP
admet-1465	49	7	the	the	DET
admet-1465	49	8	same	same	ADJ
admet-1465	49	9	possible	possible	ADJ
admet-1465	49	10	issues	issue	NOUN
admet-1465	49	11	.	.	PUNCT
admet-1465	50	1	oil	oil	NOUN
admet-1465	50	2	solution	solution	NOUN
admet-1465	50	3	tends	tend	VERB
admet-1465	50	4	to	to	PART
admet-1465	50	5	float	float	VERB
admet-1465	50	6	atop	atop	ADP
admet-1465	50	7	the	the	DET
admet-1465	50	8	release	release	NOUN
admet-1465	50	9	medium	medium	NOUN
admet-1465	50	10	and	and	CCONJ
admet-1465	50	11	stick	stick	NOUN
admet-1465	50	12	to	to	ADP
admet-1465	50	13	parts	part	NOUN
admet-1465	50	14	of	of	ADP
admet-1465	50	15	the	the	DET
admet-1465	50	16	apparatus	apparatus	NOUN
admet-1465	50	17	.	.	PUNCT
admet-1465	51	1	this	this	DET
admet-1465	51	2	problem	problem	NOUN
admet-1465	51	3	is	be	AUX
admet-1465	51	4	completely	completely	ADV
admet-1465	51	5	avoided	avoid	VERB
admet-1465	51	6	using	use	VERB
admet-1465	51	7	dialysis	dialysis	NOUN
admet-1465	51	8	bags	bag	NOUN
admet-1465	51	9	,	,	PUNCT
admet-1465	51	10	and	and	CCONJ
admet-1465	51	11	furthermore	furthermore	ADV
admet-1465	51	12	,	,	PUNCT
admet-1465	51	13	the	the	DET
admet-1465	51	14	oil	oil	NOUN
admet-1465	51	15	packed	pack	VERB
admet-1465	51	16	in	in	ADP
admet-1465	51	17	a	a	DET
admet-1465	51	18	dialysis	dialysis	NOUN
admet-1465	51	19	bag	bag	NOUN
admet-1465	51	20	imitates	imitate	VERB
admet-1465	51	21	the	the	DET
admet-1465	51	22	depot	depot	NOUN
admet-1465	51	23	that	that	PRON
admet-1465	51	24	is	be	AUX
admet-1465	51	25	formed	form	VERB
admet-1465	51	26	in	in	ADP
admet-1465	51	27	vivo	vivo	NOUN
admet-1465	51	28	after	after	ADP
admet-1465	51	29	administration	administration	NOUN
admet-1465	51	30	in	in	ADP
admet-1465	51	31	muscle	muscle	NOUN
admet-1465	51	32	tissue	tissue	NOUN
admet-1465	52	1	[	[	X
admet-1465	52	2	8	8	NUM
admet-1465	52	3	]	]	PUNCT
admet-1465	52	4	.	.	PUNCT
admet-1465	53	1	this	this	DET
admet-1465	53	2	article	article	NOUN
admet-1465	53	3	describes	describe	VERB
admet-1465	53	4	the	the	DET
admet-1465	53	5	development	development	NOUN
admet-1465	53	6	of	of	ADP
admet-1465	53	7	the	the	DET
admet-1465	53	8	ivr	ivr	PROPN
admet-1465	53	9	method	method	NOUN
admet-1465	53	10	using	use	VERB
admet-1465	53	11	a	a	DET
admet-1465	53	12	dialysis	dialysis	NOUN
admet-1465	53	13	bag	bag	NOUN
admet-1465	53	14	placed	place	VERB
admet-1465	53	15	in	in	ADP
admet-1465	53	16	a	a	DET
admet-1465	53	17	paddle	paddle	NOUN
admet-1465	53	18	apparatus	apparatus	NOUN
admet-1465	53	19	(	(	PUNCT
admet-1465	53	20	commonly	commonly	ADV
admet-1465	53	21	known	know	VERB
admet-1465	53	22	as	as	ADP
admet-1465	53	23	the	the	DET
admet-1465	53	24	usp	usp	PROPN
admet-1465	53	25	ii	ii	PROPN
admet-1465	53	26	apparatus	apparatus	PROPN
admet-1465	53	27	)	)	PUNCT
admet-1465	53	28	coupled	couple	VERB
admet-1465	53	29	to	to	ADP
admet-1465	53	30	a	a	DET
admet-1465	53	31	fiber	fiber	NOUN
admet-1465	53	32	optic	optic	NOUN
admet-1465	53	33	spectrometer	spectrometer	NOUN
admet-1465	53	34	.	.	PUNCT
admet-1465	54	1	the	the	DET
admet-1465	54	2	aim	aim	NOUN
admet-1465	54	3	of	of	ADP
admet-1465	54	4	such	such	DET
admet-1465	54	5	a	a	DET
admet-1465	54	6	setup	setup	NOUN
admet-1465	54	7	is	be	AUX
admet-1465	54	8	to	to	PART
admet-1465	54	9	provide	provide	VERB
admet-1465	54	10	an	an	DET
admet-1465	54	11	automated	automate	VERB
admet-1465	54	12	ivr	ivr	NOUN
admet-1465	54	13	method	method	NOUN
admet-1465	54	14	utilising	utilise	VERB
admet-1465	54	15	a	a	DET
admet-1465	54	16	widely	widely	ADV
admet-1465	54	17	available	available	ADJ
admet-1465	54	18	apparatus	apparatus	NOUN
admet-1465	54	19	,	,	PUNCT
admet-1465	54	20	avoiding	avoid	VERB
admet-1465	54	21	potential	potential	ADJ
admet-1465	54	22	sampling	sampling	NOUN
admet-1465	54	23	and	and	CCONJ
admet-1465	54	24	sink	sink	NOUN
admet-1465	54	25	condition	condition	NOUN
admet-1465	54	26	-	-	PUNCT
admet-1465	54	27	related	relate	VERB
admet-1465	54	28	problems	problem	NOUN
admet-1465	54	29	by	by	ADP
admet-1465	54	30	design	design	NOUN
admet-1465	54	31	,	,	PUNCT
admet-1465	54	32	for	for	ADP
admet-1465	54	33	the	the	DET
admet-1465	54	34	screening	screening	NOUN
admet-1465	54	35	of	of	ADP
admet-1465	54	36	various	various	ADJ
admet-1465	54	37	formulations	formulation	NOUN
admet-1465	54	38	in	in	ADP
admet-1465	54	39	the	the	DET
admet-1465	54	40	early	early	ADJ
admet-1465	54	41	development	development	NOUN
admet-1465	54	42	phase	phase	NOUN
admet-1465	54	43	.	.	PUNCT
admet-1465	55	1	experimental	experimental	ADJ
admet-1465	55	2	refined	refined	ADJ
admet-1465	55	3	oils	oil	NOUN
admet-1465	55	4	used	use	VERB
admet-1465	55	5	in	in	ADP
admet-1465	55	6	the	the	DET
admet-1465	55	7	solubility	solubility	NOUN
admet-1465	55	8	and	and	CCONJ
admet-1465	55	9	ivr	ivr	NOUN
admet-1465	55	10	experiments	experiment	NOUN
admet-1465	55	11	were	be	AUX
admet-1465	55	12	purchased	purchase	VERB
admet-1465	55	13	from	from	ADP
admet-1465	55	14	croda	croda	PROPN
admet-1465	55	15	(	(	PUNCT
admet-1465	55	16	united	united	ADJ
admet-1465	55	17	kingdom	kingdom	PROPN
admet-1465	55	18	)	)	PUNCT
admet-1465	55	19	and	and	CCONJ
admet-1465	55	20	include	include	VERB
admet-1465	55	21	corn	corn	NOUN
admet-1465	55	22	oil	oil	NOUN
admet-1465	55	23	,	,	PUNCT
admet-1465	55	24	peanut	peanut	NOUN
admet-1465	55	25	oil	oil	NOUN
admet-1465	55	26	,	,	PUNCT
admet-1465	55	27	cottonseed	cottonseed	NOUN
admet-1465	55	28	oil	oil	NOUN
admet-1465	55	29	,	,	PUNCT
admet-1465	55	30	sesame	sesame	NOUN
admet-1465	55	31	oil	oil	NOUN
admet-1465	55	32	and	and	CCONJ
admet-1465	55	33	castor	castor	NOUN
admet-1465	55	34	oil	oil	NOUN
admet-1465	55	35	.	.	PUNCT
admet-1465	56	1	dex	dex	NOUN
admet-1465	56	2	powder	powder	NOUN
admet-1465	56	3	was	be	AUX
admet-1465	56	4	purchased	purchase	VERB
admet-1465	56	5	from	from	ADP
admet-1465	56	6	pfizer	pfizer	NOUN
admet-1465	56	7	(	(	PUNCT
admet-1465	56	8	usa	usa	PROPN
admet-1465	56	9	)	)	PUNCT
admet-1465	56	10	.	.	PUNCT
admet-1465	57	1	cosolvents	cosolvent	NOUN
admet-1465	57	2	propylene	propylene	VERB
admet-1465	57	3	glycol	glycol	NOUN
admet-1465	57	4	monocaprylate	monocaprylate	ADJ
admet-1465	57	5	type	type	NOUN
admet-1465	57	6	ii	ii	PROPN
admet-1465	57	7	(	(	PUNCT
admet-1465	57	8	capryol	capryol	NOUN
admet-1465	57	9	®	®	NOUN
admet-1465	57	10	90	90	NUM
admet-1465	57	11	)	)	PUNCT
admet-1465	57	12	and	and	CCONJ
admet-1465	57	13	isopropanol	isopropanol	NOUN
admet-1465	57	14	were	be	AUX
admet-1465	57	15	purchased	purchase	VERB
admet-1465	57	16	from	from	ADP
admet-1465	57	17	gattefosse	gattefosse	PROPN
admet-1465	57	18	(	(	PUNCT
admet-1465	57	19	france	france	PROPN
admet-1465	57	20	)	)	PUNCT
admet-1465	57	21	and	and	CCONJ
admet-1465	57	22	merck	merck	PROPN
admet-1465	57	23	(	(	PUNCT
admet-1465	57	24	germany	germany	PROPN
admet-1465	57	25	)	)	PUNCT
admet-1465	57	26	,	,	PUNCT
admet-1465	57	27	respectively	respectively	ADV
admet-1465	57	28	.	.	PUNCT
admet-1465	58	1	tetrahydrofuran	tetrahydrofuran	NOUN
admet-1465	58	2	and	and	CCONJ
admet-1465	58	3	acetonitrile	acetonitrile	NOUN
admet-1465	58	4	were	be	AUX
admet-1465	58	5	obtained	obtain	VERB
admet-1465	58	6	from	from	ADP
admet-1465	58	7	merck	merck	PROPN
admet-1465	58	8	(	(	PUNCT
admet-1465	58	9	germany	germany	PROPN
admet-1465	58	10	)	)	PUNCT
admet-1465	58	11	and	and	CCONJ
admet-1465	58	12	used	use	VERB
admet-1465	58	13	for	for	ADP
admet-1465	58	14	sample	sample	NOUN
admet-1465	58	15	preparation	preparation	NOUN
admet-1465	58	16	for	for	ADP
admet-1465	58	17	hplc	hplc	NOUN
admet-1465	58	18	analysis	analysis	NOUN
admet-1465	58	19	.	.	PUNCT
admet-1465	59	1	regenerated	regenerated	ADJ
admet-1465	59	2	cellulose	cellulose	NOUN
admet-1465	59	3	(	(	PUNCT
admet-1465	59	4	rc	rc	PROPN
admet-1465	59	5	,	,	PUNCT
admet-1465	59	6	mwco	mwco	PROPN
admet-1465	59	7	(	(	PUNCT
admet-1465	59	8	molecular	molecular	ADJ
admet-1465	59	9	weight	weight	NOUN
admet-1465	59	10	cut	cut	NOUN
admet-1465	59	11	-	-	PUNCT
admet-1465	59	12	off	off	ADP
admet-1465	59	13	)	)	PUNCT
admet-1465	59	14	50	50	NUM
admet-1465	59	15	kda	kda	NOUN
admet-1465	59	16	)	)	PUNCT
admet-1465	59	17	and	and	CCONJ
admet-1465	59	18	cellulose	cellulose	NOUN
admet-1465	59	19	ester	ester	NOUN
admet-1465	59	20	(	(	PUNCT
admet-1465	59	21	ce	ce	PROPN
admet-1465	59	22	,	,	PUNCT
admet-1465	59	23	mwco	mwco	NOUN
admet-1465	59	24	300	300	NUM
admet-1465	59	25	kda	kda	NOUN
admet-1465	59	26	)	)	PUNCT
admet-1465	59	27	dialysis	dialysis	NOUN
admet-1465	59	28	membranes	membrane	NOUN
admet-1465	59	29	,	,	PUNCT
admet-1465	59	30	used	use	VERB
admet-1465	59	31	as	as	ADP
admet-1465	59	32	formulation	formulation	NOUN
admet-1465	59	33	carriers	carrier	NOUN
admet-1465	59	34	,	,	PUNCT
admet-1465	59	35	were	be	AUX
admet-1465	59	36	obtained	obtain	VERB
admet-1465	59	37	from	from	ADP
admet-1465	59	38	spectrum	spectrum	NOUN
admet-1465	59	39	labs	labs	PROPN
admet-1465	59	40	(	(	PUNCT
admet-1465	59	41	usa	usa	PROPN
admet-1465	59	42	)	)	PUNCT
admet-1465	59	43	.	.	PUNCT
admet-1465	60	1	regenerated	regenerate	VERB
admet-1465	60	2	cellulose	cellulose	NOUN
admet-1465	60	3	filter	filter	NOUN
admet-1465	60	4	membranes	membrane	NOUN
admet-1465	60	5	used	use	VERB
admet-1465	60	6	for	for	ADP
admet-1465	60	7	medium	medium	ADJ
admet-1465	60	8	degassing	degassing	NOUN
admet-1465	60	9	were	be	AUX
admet-1465	60	10	obtained	obtain	VERB
admet-1465	60	11	from	from	ADP
admet-1465	60	12	ge	ge	PROPN
admet-1465	60	13	healthcare	healthcare	PROPN
admet-1465	60	14	(	(	PUNCT
admet-1465	60	15	usa	usa	PROPN
admet-1465	60	16	)	)	PUNCT
admet-1465	60	17	.	.	PUNCT
admet-1465	61	1	demineralized	demineralized	ADJ
admet-1465	61	2	water	water	NOUN
admet-1465	61	3	was	be	AUX
admet-1465	61	4	used	use	VERB
admet-1465	61	5	throughout	throughout	ADP
admet-1465	61	6	the	the	DET
admet-1465	61	7	study	study	NOUN
admet-1465	61	8	.	.	PUNCT
admet-1465	62	1	all	all	DET
admet-1465	62	2	chemicals	chemical	NOUN
admet-1465	62	3	and	and	CCONJ
admet-1465	62	4	solvents	solvent	NOUN
admet-1465	62	5	were	be	AUX
admet-1465	62	6	of	of	ADP
admet-1465	62	7	analytical	analytical	ADJ
admet-1465	62	8	grade	grade	NOUN
admet-1465	62	9	.	.	PUNCT
admet-1465	63	1	for	for	ADP
admet-1465	63	2	the	the	DET
admet-1465	63	3	determination	determination	NOUN
admet-1465	63	4	of	of	ADP
admet-1465	63	5	partition	partition	NOUN
admet-1465	63	6	coefficient	coefficient	NOUN
admet-1465	63	7	and	and	CCONJ
admet-1465	63	8	medium	medium	NOUN
admet-1465	63	9	in	in	ADP
admet-1465	63	10	ivr	ivr	PROPN
admet-1465	63	11	studies	study	NOUN
admet-1465	63	12	,	,	PUNCT
admet-1465	63	13	phosphate	phosphate	ADJ
admet-1465	63	14	buffer	buffer	NOUN
admet-1465	63	15	ph	ph	VERB
admet-1465	63	16	7.4	7.4	NUM
admet-1465	63	17	,	,	PUNCT
admet-1465	63	18	made	make	VERB
admet-1465	63	19	from	from	ADP
admet-1465	63	20	sodium	sodium	NOUN
admet-1465	63	21	hydroxide	hydroxide	NOUN
admet-1465	63	22	and	and	CCONJ
admet-1465	63	23	potassium	potassium	NOUN
admet-1465	63	24	dihydrogen	dihydrogen	NOUN
admet-1465	63	25	phosphate	phosphate	NOUN
admet-1465	63	26	,	,	PUNCT
admet-1465	63	27	obtained	obtain	VERB
admet-1465	63	28	from	from	ADP
admet-1465	63	29	kemika	kemika	X
admet-1465	63	30	(	(	PUNCT
admet-1465	63	31	croatia	croatia	PROPN
admet-1465	63	32	)	)	PUNCT
admet-1465	63	33	,	,	PUNCT
admet-1465	63	34	was	be	AUX
admet-1465	63	35	used	use	VERB
admet-1465	63	36	.	.	PUNCT
admet-1465	64	1	ethanol	ethanol	NOUN
admet-1465	64	2	was	be	AUX
admet-1465	64	3	obtained	obtain	VERB
admet-1465	64	4	from	from	ADP
admet-1465	64	5	kemika	kemika	X
admet-1465	64	6	(	(	PUNCT
admet-1465	64	7	croatia	croatia	PROPN
admet-1465	64	8	)	)	PUNCT
admet-1465	64	9	.	.	PUNCT
admet-1465	65	1	solubility	solubility	NOUN
admet-1465	65	2	of	of	ADP
admet-1465	65	3	dex	dex	NOUN
admet-1465	65	4	solubility	solubility	NOUN
admet-1465	65	5	of	of	ADP
admet-1465	65	6	dex	dex	NOUN
admet-1465	65	7	was	be	AUX
admet-1465	65	8	determined	determine	VERB
admet-1465	65	9	in	in	ADP
admet-1465	65	10	five	five	NUM
admet-1465	65	11	different	different	ADJ
admet-1465	65	12	vegetable	vegetable	NOUN
admet-1465	65	13	oils	oil	NOUN
admet-1465	65	14	(	(	PUNCT
admet-1465	65	15	castor	castor	NOUN
admet-1465	65	16	,	,	PUNCT
admet-1465	65	17	peanut	peanut	NOUN
admet-1465	65	18	,	,	PUNCT
admet-1465	65	19	cottonseed	cottonseed	NOUN
admet-1465	65	20	,	,	PUNCT
admet-1465	65	21	sesame	sesame	NOUN
admet-1465	65	22	and	and	CCONJ
admet-1465	65	23	corn	corn	NOUN
admet-1465	65	24	)	)	PUNCT
admet-1465	65	25	,	,	PUNCT
admet-1465	65	26	pure	pure	ADJ
admet-1465	65	27	or	or	CCONJ
admet-1465	65	28	mixed	mixed	ADJ
admet-1465	65	29	with	with	ADP
admet-1465	65	30	10	10	NUM
admet-1465	65	31	and	and	CCONJ
admet-1465	65	32	20	20	NUM
admet-1465	65	33	%	%	NOUN
admet-1465	65	34	(	(	PUNCT
admet-1465	65	35	v	v	NOUN
admet-1465	65	36	/	/	SYM
admet-1465	65	37	v	v	NOUN
admet-1465	65	38	)	)	PUNCT
admet-1465	65	39	of	of	ADP
admet-1465	65	40	one	one	NUM
admet-1465	65	41	of	of	ADP
admet-1465	65	42	the	the	DET
admet-1465	65	43	cosolvents	cosolvent	NOUN
admet-1465	65	44	(	(	PUNCT
admet-1465	65	45	capryol	capryol	NOUN
admet-1465	65	46	®	®	NOUN
admet-1465	65	47	90	90	NUM
admet-1465	65	48	or	or	CCONJ
admet-1465	65	49	isopropanol	isopropanol	NOUN
admet-1465	65	50	)	)	PUNCT
admet-1465	65	51	by	by	ADP
admet-1465	65	52	dissolving	dissolve	VERB
admet-1465	65	53	an	an	DET
admet-1465	65	54	excess	excess	ADJ
admet-1465	65	55	amount	amount	NOUN
admet-1465	65	56	of	of	ADP
admet-1465	65	57	dex	dex	NOUN
admet-1465	65	58	in	in	ADP
admet-1465	65	59	3	3	NUM
admet-1465	65	60	ml	ml	NOUN
admet-1465	65	61	of	of	ADP
admet-1465	65	62	the	the	DET
admet-1465	65	63	solvent	solvent	NOUN
admet-1465	65	64	/	/	SYM
admet-1465	65	65	mixture	mixture	NOUN
admet-1465	65	66	using	use	VERB
admet-1465	65	67	a	a	DET
admet-1465	65	68	shaker	shaker	NOUN
admet-1465	65	69	at	at	ADP
admet-1465	65	70	37	37	NUM
admet-1465	65	71	°	°	ADP
admet-1465	65	72	c	c	NOUN
admet-1465	65	73	and	and	CCONJ
admet-1465	65	74	100	100	NUM
admet-1465	65	75	rpm	rpm	NOUN
admet-1465	65	76	for	for	ADP
admet-1465	65	77	24	24	NUM
admet-1465	65	78	hours	hour	NOUN
admet-1465	65	79	.	.	NOUN
admet-1465	66	1	1	1	NUM
admet-1465	66	2	ml	ml	NOUN
admet-1465	66	3	of	of	ADP
admet-1465	66	4	each	each	DET
admet-1465	66	5	supernatant	supernatant	NOUN
admet-1465	66	6	was	be	AUX
admet-1465	66	7	sampled	sample	VERB
admet-1465	66	8	after	after	ADP
admet-1465	66	9	2	2	NUM
admet-1465	66	10	hours	hour	NOUN
admet-1465	66	11	and	and	CCONJ
admet-1465	66	12	24	24	NUM
admet-1465	66	13	hours	hour	NOUN
admet-1465	66	14	and	and	CCONJ
admet-1465	66	15	then	then	ADV
admet-1465	66	16	centrifuged	centrifuge	VERB
admet-1465	66	17	at	at	ADP
admet-1465	66	18	10000	10000	NUM
admet-1465	66	19	rpm	rpm	NOUN
admet-1465	66	20	for	for	ADP
admet-1465	66	21	15	15	NUM
admet-1465	66	22	minutes	minute	NOUN
admet-1465	66	23	to	to	PART
admet-1465	66	24	remove	remove	VERB
admet-1465	66	25	the	the	DET
admet-1465	66	26	undissolved	undissolved	ADJ
admet-1465	66	27	dex	dex	NOUN
admet-1465	66	28	.	.	PUNCT
admet-1465	67	1	after	after	ADP
admet-1465	67	2	centrifugation	centrifugation	NOUN
admet-1465	67	3	,	,	PUNCT
admet-1465	67	4	200	200	NUM
admet-1465	67	5	µl	µl	NOUN
admet-1465	67	6	of	of	ADP
admet-1465	67	7	supernatant	supernatant	NOUN
admet-1465	67	8	was	be	AUX
admet-1465	67	9	diluted	dilute	VERB
admet-1465	67	10	with	with	ADP
admet-1465	67	11	600	600	NUM
admet-1465	67	12	µl	µl	NOUN
admet-1465	67	13	of	of	ADP
admet-1465	67	14	tetrahydrofuran	tetrahydrofuran	NOUN
admet-1465	67	15	and	and	CCONJ
admet-1465	67	16	800	800	NUM
admet-1465	67	17	µl	µl	NOUN
admet-1465	67	18	of	of	ADP
admet-1465	67	19	acetonitrile	acetonitrile	NOUN
admet-1465	67	20	in	in	ADP
admet-1465	67	21	vials	vial	NOUN
admet-1465	67	22	for	for	ADP
admet-1465	67	23	the	the	DET
admet-1465	67	24	hplc	hplc	NOUN
admet-1465	67	25	analysis	analysis	NOUN
admet-1465	67	26	.	.	PUNCT
admet-1465	68	1	all	all	DET
admet-1465	68	2	samples	sample	NOUN
admet-1465	68	3	were	be	AUX
admet-1465	68	4	prepared	prepare	VERB
admet-1465	68	5	in	in	ADP
admet-1465	68	6	triplicates	triplicate	NOUN
admet-1465	68	7	.	.	PUNCT
admet-1465	69	1	castor	castor	NOUN
admet-1465	69	2	oil	oil	NOUN
admet-1465	69	3	combined	combine	VERB
admet-1465	69	4	with	with	ADP
admet-1465	69	5	20	20	NUM
admet-1465	69	6	%	%	NOUN
admet-1465	69	7	(	(	PUNCT
admet-1465	69	8	v	v	NOUN
admet-1465	69	9	/	/	SYM
admet-1465	69	10	v	v	NOUN
admet-1465	69	11	)	)	PUNCT
admet-1465	69	12	of	of	ADP
admet-1465	69	13	isopropanol	isopropanol	NOUN
admet-1465	69	14	and	and	CCONJ
admet-1465	69	15	castor	castor	NOUN
admet-1465	69	16	oil	oil	NOUN
admet-1465	69	17	with	with	ADP
admet-1465	69	18	20	20	NUM
admet-1465	69	19	%	%	NOUN
admet-1465	69	20	(	(	PUNCT
admet-1465	69	21	v	v	NOUN
admet-1465	69	22	/	/	SYM
admet-1465	69	23	v	v	NOUN
admet-1465	69	24	)	)	PUNCT
admet-1465	69	25	of	of	ADP
admet-1465	69	26	capryol	capryol	NOUN
admet-1465	69	27	®	®	NOUN
admet-1465	69	28	90	90	NUM
admet-1465	69	29	were	be	AUX
admet-1465	69	30	chosen	choose	VERB
admet-1465	69	31	as	as	ADP
admet-1465	69	32	the	the	DET
admet-1465	69	33	best	good	ADJ
admet-1465	69	34	formulations	formulation	NOUN
admet-1465	69	35	for	for	ADP
admet-1465	69	36	the	the	DET
admet-1465	69	37	following	follow	VERB
admet-1465	69	38	experiments	experiment	NOUN
admet-1465	69	39	.	.	PUNCT
admet-1465	70	1	determination	determination	NOUN
admet-1465	70	2	of	of	ADP
admet-1465	70	3	partition	partition	NOUN
admet-1465	70	4	coefficients	coefficient	NOUN
admet-1465	70	5	papp	papp	NOUN
admet-1465	70	6	(	(	PUNCT
admet-1465	70	7	apparent	apparent	ADJ
admet-1465	70	8	partition	partition	NOUN
admet-1465	70	9	coefficient	coefficient	NOUN
admet-1465	70	10	)	)	PUNCT
admet-1465	70	11	was	be	AUX
admet-1465	70	12	used	use	VERB
admet-1465	70	13	to	to	PART
admet-1465	70	14	quantify	quantify	VERB
admet-1465	70	15	the	the	DET
admet-1465	70	16	partitioning	partitioning	NOUN
admet-1465	70	17	of	of	ADP
admet-1465	70	18	dex	dex	NOUN
admet-1465	70	19	in	in	ADP
admet-1465	70	20	test	test	NOUN
admet-1465	70	21	solutions	solution	NOUN
admet-1465	70	22	.	.	PUNCT
admet-1465	71	1	equation	equation	NOUN
admet-1465	71	2	(	(	PUNCT
admet-1465	71	3	1	1	X
admet-1465	71	4	)	)	PUNCT
admet-1465	71	5	describes	describe	VERB
admet-1465	71	6	the	the	DET
admet-1465	71	7	calculation	calculation	NOUN
admet-1465	71	8	of	of	ADP
admet-1465	71	9	papp	papp	NOUN
admet-1465	71	10	:	:	PUNCT
admet-1465	72	1	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	72	2	filip	filip	PROPN
admet-1465	72	3	kozlina	kozlina	PROPN
admet-1465	72	4	et	et	PROPN
admet-1465	72	5	al	al	PROPN
admet-1465	72	6	.	.	PROPN
admet-1465	72	7	admet	admet	PROPN
admet-1465	72	8	&	&	CCONJ
admet-1465	72	9	dmpk	dmpk	PROPN
admet-1465	72	10	10(4	10(4	NUM
admet-1465	72	11	)	)	PUNCT
admet-1465	72	12	(	(	PUNCT
admet-1465	72	13	2022	2022	NUM
admet-1465	72	14	)	)	PUNCT
admet-1465	72	15	315	315	NUM
admet-1465	72	16	-	-	SYM
admet-1465	72	17	329	329	NUM
admet-1465	72	18	318	318	NUM
admet-1465	72	19	𝑃app	𝑃app	PROPN
admet-1465	72	20	=	=	SYM
admet-1465	72	21	ci−𝑐v	ci−𝑐v	PROPN
admet-1465	72	22	𝑐v	𝑐v	ADP
admet-1465	72	23	∙	∙	PROPN
admet-1465	72	24	𝑉v	𝑉v	PROPN
admet-1465	72	25	𝑉u	𝑉u	PROPN
admet-1465	72	26	(	(	PUNCT
admet-1465	72	27	1	1	NUM
admet-1465	72	28	)	)	PUNCT
admet-1465	72	29	where	where	SCONJ
admet-1465	72	30	ci	ci	NOUN
admet-1465	72	31	represents	represent	VERB
admet-1465	72	32	the	the	DET
admet-1465	72	33	concentration	concentration	NOUN
admet-1465	72	34	of	of	ADP
admet-1465	72	35	prepared	prepared	ADJ
admet-1465	72	36	oil	oil	NOUN
admet-1465	72	37	solution	solution	NOUN
admet-1465	72	38	for	for	ADP
admet-1465	72	39	determination	determination	NOUN
admet-1465	72	40	of	of	ADP
admet-1465	72	41	papp	papp	NOUN
admet-1465	72	42	,	,	PUNCT
admet-1465	72	43	cv	cv	PROPN
admet-1465	72	44	represents	represent	VERB
admet-1465	72	45	the	the	DET
admet-1465	72	46	concentration	concentration	NOUN
admet-1465	72	47	of	of	ADP
admet-1465	72	48	drug	drug	NOUN
admet-1465	72	49	in	in	ADP
admet-1465	72	50	the	the	DET
admet-1465	72	51	aqueous	aqueous	ADJ
admet-1465	72	52	phase	phase	NOUN
admet-1465	72	53	(	(	PUNCT
admet-1465	72	54	phosphate	phosphate	ADJ
admet-1465	72	55	buffer	buffer	NOUN
admet-1465	72	56	ph	ph	VERB
admet-1465	72	57	7.4	7.4	NUM
admet-1465	72	58	)	)	PUNCT
admet-1465	72	59	at	at	ADP
admet-1465	72	60	equilibrium	equilibrium	NOUN
admet-1465	72	61	,	,	PUNCT
admet-1465	72	62	while	while	SCONJ
admet-1465	72	63	vv	vv	NOUN
admet-1465	72	64	and	and	CCONJ
admet-1465	72	65	vu	vu	PROPN
admet-1465	72	66	are	be	AUX
admet-1465	72	67	volumes	volume	NOUN
admet-1465	72	68	of	of	ADP
admet-1465	72	69	aqueous	aqueous	ADJ
admet-1465	72	70	and	and	CCONJ
admet-1465	72	71	oil	oil	NOUN
admet-1465	72	72	phase	phase	NOUN
admet-1465	72	73	at	at	ADP
admet-1465	72	74	the	the	DET
admet-1465	72	75	end	end	NOUN
admet-1465	72	76	of	of	ADP
admet-1465	72	77	the	the	DET
admet-1465	72	78	experiment	experiment	NOUN
admet-1465	72	79	,	,	PUNCT
admet-1465	72	80	respectively	respectively	ADV
admet-1465	72	81	[	[	X
admet-1465	72	82	8	8	NUM
admet-1465	72	83	]	]	PUNCT
admet-1465	72	84	.	.	PUNCT
admet-1465	73	1	the	the	DET
admet-1465	73	2	partition	partition	NOUN
admet-1465	73	3	coefficient	coefficient	NOUN
admet-1465	73	4	between	between	ADP
admet-1465	73	5	the	the	DET
admet-1465	73	6	formulation	formulation	NOUN
admet-1465	73	7	(	(	PUNCT
admet-1465	73	8	castor	castor	NOUN
admet-1465	73	9	oil	oil	NOUN
admet-1465	73	10	,	,	PUNCT
admet-1465	73	11	cosolvent	cosolvent	NOUN
admet-1465	73	12	and	and	CCONJ
admet-1465	73	13	dex	dex	NOUN
admet-1465	73	14	,	,	PUNCT
admet-1465	73	15	representing	represent	VERB
admet-1465	73	16	the	the	DET
admet-1465	73	17	oil	oil	NOUN
admet-1465	73	18	phase	phase	NOUN
admet-1465	73	19	)	)	PUNCT
admet-1465	73	20	and	and	CCONJ
admet-1465	73	21	the	the	DET
admet-1465	73	22	phosphate	phosphate	ADJ
admet-1465	73	23	buffer	buffer	NOUN
admet-1465	73	24	ph	ph	VERB
admet-1465	73	25	7.4	7.4	NUM
admet-1465	73	26	(	(	PUNCT
admet-1465	73	27	representing	represent	VERB
admet-1465	73	28	the	the	DET
admet-1465	73	29	aqueous	aqueous	ADJ
admet-1465	73	30	phase	phase	NOUN
admet-1465	73	31	)	)	PUNCT
admet-1465	73	32	was	be	AUX
admet-1465	73	33	determined	determine	VERB
admet-1465	73	34	by	by	ADP
admet-1465	73	35	mixing	mix	VERB
admet-1465	73	36	them	they	PRON
admet-1465	73	37	at	at	ADP
admet-1465	73	38	1:1	1:1	NUM
admet-1465	73	39	volume	volume	NOUN
admet-1465	73	40	ratio	ratio	NOUN
admet-1465	73	41	and	and	CCONJ
admet-1465	73	42	shaking	shake	VERB
admet-1465	73	43	at	at	ADP
admet-1465	73	44	37	37	NUM
admet-1465	73	45	°	°	ADP
admet-1465	73	46	c	c	NOUN
admet-1465	73	47	and	and	CCONJ
admet-1465	73	48	100	100	NUM
admet-1465	73	49	rpm	rpm	NOUN
admet-1465	73	50	for	for	ADP
admet-1465	73	51	24	24	NUM
admet-1465	73	52	hours	hour	NOUN
admet-1465	73	53	.	.	PUNCT
admet-1465	74	1	the	the	DET
admet-1465	74	2	concentration	concentration	NOUN
admet-1465	74	3	of	of	ADP
admet-1465	74	4	added	add	VERB
admet-1465	74	5	dex	dex	NOUN
admet-1465	74	6	was	be	AUX
admet-1465	74	7	determined	determine	VERB
admet-1465	74	8	previously	previously	ADV
admet-1465	74	9	in	in	ADP
admet-1465	74	10	the	the	DET
admet-1465	74	11	solubility	solubility	NOUN
admet-1465	74	12	study	study	NOUN
admet-1465	74	13	(	(	PUNCT
admet-1465	74	14	1	1	NUM
admet-1465	74	15	mg	mg	NUM
admet-1465	74	16	/	/	SYM
admet-1465	74	17	ml	ml	X
admet-1465	74	18	in	in	ADP
admet-1465	74	19	capryol	capryol	NOUN
admet-1465	74	20	®	®	VERB
admet-1465	74	21	90	90	NUM
admet-1465	74	22	mixture	mixture	NOUN
admet-1465	74	23	and	and	CCONJ
admet-1465	74	24	2	2	NUM
admet-1465	74	25	mg	mg	NUM
admet-1465	74	26	/	/	SYM
admet-1465	74	27	ml	ml	NOUN
admet-1465	74	28	in	in	ADP
admet-1465	74	29	isopropanol	isopropanol	NOUN
admet-1465	74	30	mixture	mixture	NOUN
admet-1465	74	31	)	)	PUNCT
admet-1465	74	32	.	.	PUNCT
admet-1465	75	1	after	after	SCONJ
admet-1465	75	2	2	2	NUM
admet-1465	75	3	and	and	CCONJ
admet-1465	75	4	24	24	NUM
admet-1465	75	5	hours	hour	NOUN
admet-1465	75	6	,	,	PUNCT
admet-1465	75	7	oil	oil	NOUN
admet-1465	75	8	and	and	CCONJ
admet-1465	75	9	aqueous	aqueous	ADJ
admet-1465	75	10	phases	phase	NOUN
admet-1465	75	11	were	be	AUX
admet-1465	75	12	sampled	sample	VERB
admet-1465	75	13	(	(	PUNCT
admet-1465	75	14	1	1	NUM
admet-1465	75	15	ml	ml	NOUN
admet-1465	75	16	)	)	PUNCT
admet-1465	75	17	and	and	CCONJ
admet-1465	75	18	centrifuged	centrifuge	VERB
admet-1465	75	19	for	for	ADP
admet-1465	75	20	15	15	NUM
admet-1465	75	21	minutes	minute	NOUN
admet-1465	75	22	at	at	ADP
admet-1465	75	23	10000	10000	NUM
admet-1465	75	24	rpm	rpm	NOUN
admet-1465	75	25	.	.	PUNCT
admet-1465	76	1	the	the	DET
admet-1465	76	2	obtained	obtain	VERB
admet-1465	76	3	supernatant	supernatant	NOUN
admet-1465	76	4	was	be	AUX
admet-1465	76	5	diluted	dilute	VERB
admet-1465	76	6	as	as	ADP
admet-1465	76	7	already	already	ADV
admet-1465	76	8	described	describe	VERB
admet-1465	76	9	in	in	ADP
admet-1465	76	10	the	the	DET
admet-1465	76	11	solubility	solubility	NOUN
admet-1465	76	12	experiments	experiment	NOUN
admet-1465	76	13	.	.	PUNCT
admet-1465	77	1	all	all	DET
admet-1465	77	2	samples	sample	NOUN
admet-1465	77	3	were	be	AUX
admet-1465	77	4	prepared	prepare	VERB
admet-1465	77	5	in	in	ADP
admet-1465	77	6	triplicates	triplicate	NOUN
admet-1465	77	7	.	.	PUNCT
admet-1465	78	1	hplc	hplc	NOUN
admet-1465	78	2	analysis	analysis	NOUN
admet-1465	78	3	samples	sample	NOUN
admet-1465	78	4	from	from	ADP
admet-1465	78	5	the	the	DET
admet-1465	78	6	solubility	solubility	NOUN
admet-1465	78	7	and	and	CCONJ
admet-1465	78	8	partitioning	partition	VERB
admet-1465	78	9	studies	study	NOUN
admet-1465	78	10	were	be	AUX
admet-1465	78	11	analysed	analyse	VERB
admet-1465	78	12	on	on	ADP
admet-1465	78	13	hplc	hplc	NOUN
admet-1465	78	14	system	system	NOUN
admet-1465	78	15	agilent	agilent	PROPN
admet-1465	78	16	1100/1200	1100/1200	NUM
admet-1465	78	17	series	series	NOUN
admet-1465	78	18	connected	connect	VERB
admet-1465	78	19	to	to	PART
admet-1465	78	20	diode	diode	VERB
admet-1465	78	21	array	array	NOUN
admet-1465	78	22	detector	detector	NOUN
admet-1465	78	23	adjusted	adjust	VERB
admet-1465	78	24	to	to	ADP
admet-1465	78	25	241	241	NUM
admet-1465	78	26	nm	nm	PROPN
admet-1465	78	27	.	.	PUNCT
admet-1465	79	1	kinetex	kinetex	PROPN
admet-1465	79	2	c18	c18	PROPN
admet-1465	79	3	column	column	NOUN
admet-1465	79	4	(	(	PUNCT
admet-1465	79	5	4.6	4.6	NUM
admet-1465	79	6	x	x	SYM
admet-1465	79	7	50	50	NUM
admet-1465	79	8	mm	mm	NOUN
admet-1465	79	9	,	,	PUNCT
admet-1465	79	10	particles	particle	VERB
admet-1465	79	11	2.6	2.6	NUM
admet-1465	79	12	μm	μm	NUM
admet-1465	79	13	and	and	CCONJ
admet-1465	79	14	pore	pore	ADJ
admet-1465	79	15	size	size	NOUN
admet-1465	79	16	100	100	NUM
admet-1465	79	17	å	å	NOUN
admet-1465	79	18	)	)	PUNCT
admet-1465	79	19	by	by	ADP
admet-1465	79	20	phenomenex	phenomenex	ADV
admet-1465	79	21	(	(	PUNCT
admet-1465	79	22	usa	usa	PROPN
admet-1465	79	23	)	)	PUNCT
admet-1465	79	24	,	,	PUNCT
admet-1465	79	25	heated	heat	VERB
admet-1465	79	26	to	to	ADP
admet-1465	79	27	40	40	NUM
admet-1465	79	28	°	°	NOUN
admet-1465	79	29	c	c	NOUN
admet-1465	79	30	,	,	PUNCT
admet-1465	79	31	was	be	AUX
admet-1465	79	32	used	use	VERB
admet-1465	79	33	.	.	PUNCT
admet-1465	80	1	the	the	DET
admet-1465	80	2	chromatograms	chromatogram	NOUN
admet-1465	80	3	were	be	AUX
admet-1465	80	4	obtained	obtain	VERB
admet-1465	80	5	with	with	ADP
admet-1465	80	6	a	a	DET
admet-1465	80	7	gradient	gradient	ADJ
admet-1465	80	8	elution	elution	NOUN
admet-1465	80	9	,	,	PUNCT
admet-1465	80	10	where	where	SCONJ
admet-1465	80	11	acetonitrile	acetonitrile	NOUN
admet-1465	80	12	and	and	CCONJ
admet-1465	80	13	buffer	buffer	VERB
admet-1465	80	14	ph	ph	X
admet-1465	80	15	2.0	2.0	NUM
admet-1465	80	16	were	be	AUX
admet-1465	80	17	components	component	NOUN
admet-1465	80	18	of	of	ADP
admet-1465	80	19	the	the	DET
admet-1465	80	20	mobile	mobile	ADJ
admet-1465	80	21	phase	phase	NOUN
admet-1465	80	22	.	.	PUNCT
admet-1465	81	1	injector	injector	NOUN
admet-1465	81	2	temperature	temperature	NOUN
admet-1465	81	3	was	be	AUX
admet-1465	81	4	adjusted	adjust	VERB
admet-1465	81	5	at	at	ADP
admet-1465	81	6	35	35	NUM
admet-1465	81	7	°	°	NOUN
admet-1465	81	8	c	c	NOUN
admet-1465	81	9	,	,	PUNCT
admet-1465	81	10	the	the	DET
admet-1465	81	11	flow	flow	NOUN
admet-1465	81	12	rate	rate	NOUN
admet-1465	81	13	at	at	ADP
admet-1465	81	14	1.8	1.8	NUM
admet-1465	81	15	ml	ml	NOUN
admet-1465	81	16	/	/	SYM
admet-1465	81	17	min	min	NOUN
admet-1465	81	18	and	and	CCONJ
admet-1465	81	19	sample	sample	NOUN
admet-1465	81	20	injection	injection	NOUN
admet-1465	81	21	volume	volume	NOUN
admet-1465	81	22	at	at	ADP
admet-1465	81	23	10	10	NUM
admet-1465	81	24	μl	μl	NOUN
admet-1465	81	25	.	.	PUNCT
admet-1465	82	1	the	the	DET
admet-1465	82	2	stock	stock	NOUN
admet-1465	82	3	solution	solution	NOUN
admet-1465	82	4	used	use	VERB
admet-1465	82	5	in	in	ADP
admet-1465	82	6	solubility	solubility	NOUN
admet-1465	82	7	and	and	CCONJ
admet-1465	82	8	partitioning	partition	VERB
admet-1465	82	9	studies	study	NOUN
admet-1465	82	10	was	be	AUX
admet-1465	82	11	prepared	prepare	VERB
admet-1465	82	12	by	by	ADP
admet-1465	82	13	dissolving	dissolve	VERB
admet-1465	82	14	15	15	NUM
admet-1465	82	15	mg	mg	NOUN
admet-1465	82	16	of	of	ADP
admet-1465	82	17	dex	dex	NOUN
admet-1465	82	18	in	in	ADP
admet-1465	82	19	25	25	NUM
admet-1465	82	20	ml	ml	NOUN
admet-1465	82	21	of	of	ADP
admet-1465	82	22	tetrahydrofuran	tetrahydrofuran	NOUN
admet-1465	82	23	.	.	PUNCT
admet-1465	83	1	the	the	DET
admet-1465	83	2	two	two	NUM
admet-1465	83	3	working	work	VERB
admet-1465	83	4	standard	standard	ADJ
admet-1465	83	5	solutions	solution	NOUN
admet-1465	83	6	were	be	AUX
admet-1465	83	7	obtained	obtain	VERB
admet-1465	83	8	by	by	ADP
admet-1465	83	9	further	far	ADV
admet-1465	83	10	diluting	dilute	VERB
admet-1465	83	11	the	the	DET
admet-1465	83	12	stock	stock	NOUN
admet-1465	83	13	solution	solution	NOUN
admet-1465	83	14	.	.	PUNCT
admet-1465	84	1	the	the	DET
admet-1465	84	2	first	first	ADJ
admet-1465	84	3	one	one	NUM
admet-1465	84	4	was	be	AUX
admet-1465	84	5	obtained	obtain	VERB
admet-1465	84	6	by	by	ADP
admet-1465	84	7	diluting	dilute	VERB
admet-1465	84	8	5	5	NUM
admet-1465	84	9	ml	ml	NOUN
admet-1465	84	10	of	of	ADP
admet-1465	84	11	stock	stock	NOUN
admet-1465	84	12	solution	solution	NOUN
admet-1465	84	13	in	in	ADP
admet-1465	84	14	25	25	NUM
admet-1465	84	15	ml	ml	NOUN
admet-1465	84	16	of	of	ADP
admet-1465	84	17	acetonitrile	acetonitrile	NOUN
admet-1465	84	18	and	and	CCONJ
admet-1465	84	19	was	be	AUX
admet-1465	84	20	used	use	VERB
admet-1465	84	21	for	for	ADP
admet-1465	84	22	assay	assay	NOUN
admet-1465	84	23	of	of	ADP
admet-1465	84	24	dex	dex	NOUN
admet-1465	84	25	in	in	ADP
admet-1465	84	26	castor	castor	NOUN
admet-1465	84	27	oil	oil	NOUN
admet-1465	84	28	solutions	solution	NOUN
admet-1465	84	29	.	.	PUNCT
admet-1465	85	1	the	the	DET
admet-1465	85	2	second	second	ADJ
admet-1465	85	3	standard	standard	ADJ
admet-1465	85	4	solution	solution	NOUN
admet-1465	85	5	was	be	AUX
admet-1465	85	6	prepared	prepare	VERB
admet-1465	85	7	by	by	ADP
admet-1465	85	8	diluting	dilute	VERB
admet-1465	85	9	1	1	NUM
admet-1465	85	10	ml	ml	NOUN
admet-1465	85	11	of	of	ADP
admet-1465	85	12	stock	stock	NOUN
admet-1465	85	13	solution	solution	NOUN
admet-1465	85	14	in	in	ADP
admet-1465	85	15	100	100	NUM
admet-1465	85	16	ml	ml	NOUN
admet-1465	85	17	acetonitrile	acetonitrile	NOUN
admet-1465	85	18	.	.	PUNCT
admet-1465	86	1	it	it	PRON
admet-1465	86	2	was	be	AUX
admet-1465	86	3	used	use	VERB
admet-1465	86	4	for	for	ADP
admet-1465	86	5	dex	dex	NOUN
admet-1465	86	6	assay	assay	PROPN
admet-1465	86	7	in	in	ADP
admet-1465	86	8	solutions	solution	NOUN
admet-1465	86	9	composed	compose	VERB
admet-1465	86	10	of	of	ADP
admet-1465	86	11	four	four	NUM
admet-1465	86	12	other	other	ADJ
admet-1465	86	13	oils	oil	NOUN
admet-1465	86	14	.	.	PUNCT
admet-1465	87	1	in	in	ADP
admet-1465	87	2	vitro	vitro	X
admet-1465	87	3	release	release	NOUN
admet-1465	87	4	ivr	ivr	NOUN
admet-1465	87	5	experiments	experiment	NOUN
admet-1465	87	6	were	be	AUX
admet-1465	87	7	performed	perform	VERB
admet-1465	87	8	using	use	VERB
admet-1465	87	9	a	a	DET
admet-1465	87	10	usp	usp	PROPN
admet-1465	87	11	ii	ii	PROPN
admet-1465	87	12	apparatus	apparatus	NOUN
admet-1465	87	13	coupled	couple	VERB
admet-1465	87	14	to	to	ADP
admet-1465	87	15	the	the	DET
admet-1465	87	16	fiber	fiber	NOUN
admet-1465	87	17	optic	optic	NOUN
admet-1465	87	18	uv	uv	NOUN
admet-1465	87	19	-	-	PUNCT
admet-1465	87	20	vis	vis	X
admet-1465	87	21	spectrophotometer	spectrophotometer	X
admet-1465	87	22	(	(	PUNCT
admet-1465	87	23	agilent	agilent	PROPN
admet-1465	87	24	,	,	PUNCT
admet-1465	87	25	germany	germany	PROPN
admet-1465	87	26	)	)	PUNCT
admet-1465	87	27	for	for	ADP
admet-1465	87	28	real	real	ADJ
admet-1465	87	29	-	-	PUNCT
admet-1465	87	30	time	time	NOUN
admet-1465	87	31	absorbance	absorbance	NOUN
admet-1465	87	32	measurement	measurement	NOUN
admet-1465	87	33	.	.	PUNCT
admet-1465	88	1	the	the	DET
admet-1465	88	2	20	20	NUM
admet-1465	88	3	mm	mm	PROPN
admet-1465	88	4	optical	optical	ADJ
admet-1465	88	5	path	path	NOUN
admet-1465	88	6	probes	probe	NOUN
admet-1465	88	7	were	be	AUX
admet-1465	88	8	used	use	VERB
admet-1465	88	9	for	for	ADP
admet-1465	88	10	precise	precise	ADJ
admet-1465	88	11	online	online	ADJ
admet-1465	88	12	absorbance	absorbance	NOUN
admet-1465	88	13	determination	determination	NOUN
admet-1465	88	14	.	.	PUNCT
admet-1465	89	1	single	single	ADJ
admet-1465	89	2	point	point	NOUN
admet-1465	89	3	detection	detection	NOUN
admet-1465	89	4	at	at	ADP
admet-1465	89	5	241	241	NUM
admet-1465	89	6	nm	nm	NOUN
admet-1465	89	7	was	be	AUX
admet-1465	89	8	used	use	VERB
admet-1465	89	9	for	for	ADP
admet-1465	89	10	the	the	DET
admet-1465	89	11	calculation	calculation	NOUN
admet-1465	89	12	of	of	ADP
admet-1465	89	13	released	release	VERB
admet-1465	89	14	dex	dex	NOUN
admet-1465	89	15	,	,	PUNCT
admet-1465	89	16	while	while	SCONJ
admet-1465	89	17	a	a	DET
admet-1465	89	18	spectrum	spectrum	NOUN
admet-1465	89	19	scan	scan	NOUN
admet-1465	89	20	from	from	ADP
admet-1465	89	21	200	200	NUM
admet-1465	89	22	to	to	PART
admet-1465	89	23	300	300	NUM
admet-1465	89	24	nm	nm	NOUN
admet-1465	89	25	at	at	ADP
admet-1465	89	26	each	each	DET
admet-1465	89	27	time	time	NOUN
admet-1465	89	28	point	point	NOUN
admet-1465	89	29	was	be	AUX
admet-1465	89	30	used	use	VERB
admet-1465	89	31	later	later	ADV
admet-1465	89	32	on	on	ADV
admet-1465	89	33	for	for	ADP
admet-1465	89	34	derivative	derivative	ADJ
admet-1465	89	35	spectroscopy	spectroscopy	NOUN
admet-1465	89	36	.	.	PUNCT
admet-1465	90	1	phosphate	phosphate	ADJ
admet-1465	90	2	buffer	buffer	NOUN
admet-1465	90	3	ph	ph	X
admet-1465	90	4	7.4	7.4	NUM
admet-1465	90	5	was	be	AUX
admet-1465	90	6	used	use	VERB
admet-1465	90	7	as	as	ADP
admet-1465	90	8	a	a	DET
admet-1465	90	9	release	release	NOUN
admet-1465	90	10	medium	medium	NOUN
admet-1465	90	11	,	,	PUNCT
admet-1465	90	12	degassed	degas	VERB
admet-1465	90	13	before	before	ADP
admet-1465	90	14	every	every	DET
admet-1465	90	15	experiment	experiment	NOUN
admet-1465	90	16	following	follow	VERB
admet-1465	90	17	the	the	DET
admet-1465	90	18	usp	usp	NOUN
admet-1465	90	19	procedure	procedure	NOUN
admet-1465	90	20	[	[	X
admet-1465	90	21	19	19	NUM
admet-1465	90	22	]	]	X
admet-1465	90	23	,	,	PUNCT
admet-1465	90	24	since	since	SCONJ
admet-1465	90	25	the	the	DET
admet-1465	90	26	non	non	ADJ
admet-1465	90	27	-	-	ADJ
admet-1465	90	28	degassed	degassed	ADJ
admet-1465	90	29	medium	medium	NOUN
admet-1465	90	30	showed	show	VERB
admet-1465	90	31	unexpected	unexpected	ADJ
admet-1465	90	32	results	result	NOUN
admet-1465	90	33	due	due	ADP
admet-1465	90	34	to	to	ADP
admet-1465	90	35	light	light	ADJ
admet-1465	90	36	scattering	scattering	NOUN
admet-1465	90	37	caused	cause	VERB
admet-1465	90	38	by	by	ADP
admet-1465	90	39	bubbles	bubble	NOUN
admet-1465	90	40	of	of	ADP
admet-1465	90	41	entrapped	entrapped	ADJ
admet-1465	90	42	air	air	NOUN
admet-1465	90	43	in	in	ADP
admet-1465	90	44	the	the	DET
admet-1465	90	45	fiber	fiber	NOUN
admet-1465	90	46	optic	optic	NOUN
admet-1465	90	47	probes	probe	NOUN
admet-1465	90	48	.	.	PUNCT
admet-1465	91	1	before	before	ADP
admet-1465	91	2	each	each	DET
admet-1465	91	3	experiment	experiment	NOUN
admet-1465	91	4	,	,	PUNCT
admet-1465	91	5	dialysis	dialysis	NOUN
admet-1465	91	6	membranes	membrane	NOUN
admet-1465	91	7	were	be	AUX
admet-1465	91	8	soaked	soak	VERB
admet-1465	91	9	in	in	ADP
admet-1465	91	10	the	the	DET
admet-1465	91	11	dissolution	dissolution	NOUN
admet-1465	91	12	medium	medium	NOUN
admet-1465	91	13	for	for	ADP
admet-1465	91	14	thirty	thirty	NUM
admet-1465	91	15	minutes	minute	NOUN
admet-1465	91	16	.	.	PUNCT
admet-1465	92	1	the	the	DET
admet-1465	92	2	membranes	membrane	NOUN
admet-1465	92	3	were	be	AUX
admet-1465	92	4	cut	cut	VERB
admet-1465	92	5	in	in	ADP
admet-1465	92	6	sizes	size	NOUN
admet-1465	92	7	compatible	compatible	ADJ
admet-1465	92	8	with	with	ADP
admet-1465	92	9	the	the	DET
admet-1465	92	10	intended	intend	VERB
admet-1465	92	11	amount	amount	NOUN
admet-1465	92	12	of	of	ADP
admet-1465	92	13	test	test	NOUN
admet-1465	92	14	solutions	solution	NOUN
admet-1465	92	15	.	.	PUNCT
admet-1465	93	1	prior	prior	ADV
admet-1465	93	2	to	to	ADP
admet-1465	93	3	every	every	DET
admet-1465	93	4	experiment	experiment	NOUN
admet-1465	93	5	,	,	PUNCT
admet-1465	93	6	for	for	ADP
admet-1465	93	7	precise	precise	ADJ
admet-1465	93	8	absorbance	absorbance	NOUN
admet-1465	93	9	determination	determination	NOUN
admet-1465	93	10	,	,	PUNCT
admet-1465	93	11	the	the	DET
admet-1465	93	12	spectrophotometer	spectrophotometer	NOUN
admet-1465	93	13	baseline	baseline	NOUN
admet-1465	93	14	was	be	AUX
admet-1465	93	15	determined	determine	VERB
admet-1465	93	16	by	by	ADP
admet-1465	93	17	measuring	measure	VERB
admet-1465	93	18	the	the	DET
admet-1465	93	19	dissolution	dissolution	ADJ
admet-1465	93	20	medium	medium	NOUN
admet-1465	93	21	absorbance	absorbance	NOUN
admet-1465	93	22	.	.	PUNCT
admet-1465	94	1	subsequently	subsequently	ADV
admet-1465	94	2	,	,	PUNCT
admet-1465	94	3	the	the	DET
admet-1465	94	4	absorbance	absorbance	NOUN
admet-1465	94	5	of	of	ADP
admet-1465	94	6	prepared	prepared	ADJ
admet-1465	94	7	standard	standard	ADJ
admet-1465	94	8	solutions	solution	NOUN
admet-1465	94	9	was	be	AUX
admet-1465	94	10	also	also	ADV
admet-1465	94	11	determined	determined	ADJ
admet-1465	94	12	for	for	ADP
admet-1465	94	13	each	each	PRON
admet-1465	94	14	of	of	ADP
admet-1465	94	15	the	the	DET
admet-1465	94	16	six	six	NUM
admet-1465	94	17	used	used	ADJ
admet-1465	94	18	probes	probe	NOUN
admet-1465	94	19	individually	individually	ADV
admet-1465	94	20	to	to	PART
admet-1465	94	21	adequately	adequately	ADV
admet-1465	94	22	calibrate	calibrate	VERB
admet-1465	94	23	the	the	DET
admet-1465	94	24	optic	optic	ADJ
admet-1465	94	25	fibres	fibre	NOUN
admet-1465	94	26	.	.	PUNCT
admet-1465	95	1	standard	standard	ADJ
admet-1465	95	2	solutions	solution	NOUN
admet-1465	95	3	were	be	AUX
admet-1465	95	4	prepared	prepare	VERB
admet-1465	95	5	by	by	ADP
admet-1465	95	6	dissolving	dissolve	VERB
admet-1465	95	7	10	10	NUM
admet-1465	95	8	mg	mg	NOUN
admet-1465	95	9	of	of	ADP
admet-1465	95	10	dex	dex	NOUN
admet-1465	95	11	in	in	ADP
admet-1465	95	12	25	25	NUM
admet-1465	95	13	ml	ml	NOUN
admet-1465	95	14	of	of	ADP
admet-1465	95	15	tetrahydrofuran	tetrahydrofuran	NOUN
admet-1465	95	16	and	and	CCONJ
admet-1465	95	17	further	far	ADV
admet-1465	95	18	diluted	dilute	VERB
admet-1465	95	19	with	with	ADP
admet-1465	95	20	the	the	DET
admet-1465	95	21	dissolution	dissolution	NOUN
admet-1465	95	22	medium	medium	NOUN
admet-1465	95	23	to	to	ADP
admet-1465	95	24	100	100	NUM
admet-1465	95	25	ml	ml	NOUN
admet-1465	95	26	or	or	CCONJ
admet-1465	95	27	200	200	NUM
admet-1465	95	28	ml	ml	NOUN
admet-1465	95	29	final	final	ADJ
admet-1465	95	30	volume	volume	NOUN
admet-1465	95	31	,	,	PUNCT
admet-1465	95	32	resulting	result	VERB
admet-1465	95	33	in	in	ADP
admet-1465	95	34	0.004	0.004	NUM
admet-1465	95	35	mg	mg	NUM
admet-1465	95	36	/	/	SYM
admet-1465	95	37	ml	ml	NOUN
admet-1465	95	38	or	or	CCONJ
admet-1465	95	39	0.002	0.002	NUM
admet-1465	95	40	mg	mg	NUM
admet-1465	95	41	/	/	SYM
admet-1465	95	42	ml	ml	ADP
admet-1465	95	43	final	final	ADJ
admet-1465	95	44	concentration	concentration	NOUN
admet-1465	95	45	of	of	ADP
admet-1465	95	46	dex	dex	NOUN
admet-1465	95	47	in	in	ADP
admet-1465	95	48	the	the	DET
admet-1465	95	49	standard	standard	ADJ
admet-1465	95	50	solutions	solution	NOUN
admet-1465	95	51	for	for	ADP
admet-1465	95	52	isopropanol	isopropanol	NOUN
admet-1465	95	53	or	or	CCONJ
admet-1465	95	54	capryol	capryol	NOUN
admet-1465	95	55	®	®	NOUN
admet-1465	95	56	90	90	NUM
admet-1465	95	57	test	test	NOUN
admet-1465	95	58	solutions	solution	NOUN
admet-1465	95	59	,	,	PUNCT
admet-1465	95	60	respectively	respectively	ADV
admet-1465	95	61	.	.	PUNCT
admet-1465	96	1	this	this	PRON
admet-1465	96	2	was	be	AUX
admet-1465	96	3	equal	equal	ADJ
admet-1465	96	4	to	to	ADP
admet-1465	96	5	the	the	DET
admet-1465	96	6	concentration	concentration	NOUN
admet-1465	96	7	of	of	ADP
admet-1465	96	8	dex	dex	NOUN
admet-1465	96	9	in	in	ADP
admet-1465	96	10	the	the	DET
admet-1465	96	11	release	release	NOUN
admet-1465	96	12	medium	medium	NOUN
admet-1465	96	13	in	in	ADP
admet-1465	96	14	the	the	DET
admet-1465	96	15	case	case	NOUN
admet-1465	96	16	of	of	ADP
admet-1465	96	17	100	100	NUM
admet-1465	96	18	%	%	NOUN
admet-1465	96	19	dex	dex	NOUN
admet-1465	96	20	release	release	NOUN
admet-1465	96	21	.	.	PUNCT
admet-1465	97	1	admet	admet	PROPN
admet-1465	97	2	&	&	CCONJ
admet-1465	97	3	dmpk	dmpk	PROPN
admet-1465	97	4	10(4	10(4	NUM
admet-1465	97	5	)	)	PUNCT
admet-1465	97	6	(	(	PUNCT
admet-1465	97	7	2022	2022	NUM
admet-1465	97	8	)	)	PUNCT
admet-1465	97	9	315	315	NUM
admet-1465	97	10	-	-	SYM
admet-1465	97	11	329	329	NUM
admet-1465	97	12	dexamethasone	dexamethasone	NOUN
admet-1465	97	13	release	release	NOUN
admet-1465	97	14	from	from	ADP
admet-1465	97	15	the	the	DET
admet-1465	97	16	oil	oil	NOUN
admet-1465	97	17	solutions	solution	NOUN
admet-1465	97	18	doi	doi	NOUN
admet-1465	97	19	:	:	PUNCT
admet-1465	97	20	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	97	21	319	319	NUM
admet-1465	97	22	samples	sample	NOUN
admet-1465	97	23	for	for	ADP
admet-1465	97	24	ivr	ivr	NOUN
admet-1465	97	25	analysis	analysis	NOUN
admet-1465	97	26	were	be	AUX
admet-1465	97	27	prepared	prepare	VERB
admet-1465	97	28	by	by	ADP
admet-1465	97	29	dissolving	dissolve	VERB
admet-1465	97	30	dex	dex	NOUN
admet-1465	97	31	in	in	ADP
admet-1465	97	32	each	each	PRON
admet-1465	97	33	of	of	ADP
admet-1465	97	34	the	the	DET
admet-1465	97	35	two	two	NUM
admet-1465	97	36	oil	oil	NOUN
admet-1465	97	37	formulations	formulation	NOUN
admet-1465	97	38	to	to	ADP
admet-1465	97	39	the	the	DET
admet-1465	97	40	concentrations	concentration	NOUN
admet-1465	97	41	obtained	obtain	VERB
admet-1465	97	42	within	within	ADP
admet-1465	97	43	the	the	DET
admet-1465	97	44	solubility	solubility	NOUN
admet-1465	97	45	study	study	NOUN
admet-1465	97	46	.	.	PUNCT
admet-1465	98	1	concentration	concentration	NOUN
admet-1465	98	2	of	of	ADP
admet-1465	98	3	dex	dex	NOUN
admet-1465	98	4	in	in	ADP
admet-1465	98	5	castor	castor	NOUN
admet-1465	98	6	oil	oil	NOUN
admet-1465	98	7	containing	contain	VERB
admet-1465	98	8	20	20	NUM
admet-1465	98	9	%	%	NOUN
admet-1465	98	10	(	(	PUNCT
admet-1465	98	11	v	v	NOUN
admet-1465	98	12	/	/	SYM
admet-1465	98	13	v	v	NOUN
admet-1465	98	14	)	)	PUNCT
admet-1465	98	15	isopropanol	isopropanol	NOUN
admet-1465	98	16	was	be	AUX
admet-1465	98	17	2	2	NUM
admet-1465	98	18	mg	mg	NUM
admet-1465	98	19	/	/	SYM
admet-1465	98	20	ml	ml	NOUN
admet-1465	98	21	,	,	PUNCT
admet-1465	98	22	while	while	SCONJ
admet-1465	98	23	in	in	ADP
admet-1465	98	24	the	the	DET
admet-1465	98	25	castor	castor	NOUN
admet-1465	98	26	oil	oil	NOUN
admet-1465	98	27	containing	contain	VERB
admet-1465	98	28	20	20	NUM
admet-1465	98	29	%	%	NOUN
admet-1465	98	30	(	(	PUNCT
admet-1465	98	31	v	v	NOUN
admet-1465	98	32	/	/	SYM
admet-1465	98	33	v	v	NOUN
admet-1465	98	34	)	)	PUNCT
admet-1465	98	35	capryol	capryol	NOUN
admet-1465	98	36	®	®	NOUN
admet-1465	98	37	90	90	NUM
admet-1465	98	38	,	,	PUNCT
admet-1465	98	39	it	it	PRON
admet-1465	98	40	was	be	AUX
admet-1465	98	41	1	1	NUM
admet-1465	98	42	mg	mg	NUM
admet-1465	98	43	/	/	SYM
admet-1465	98	44	ml	ml	NOUN
admet-1465	98	45	.	.	PUNCT
admet-1465	99	1	samples	sample	NOUN
admet-1465	99	2	were	be	AUX
admet-1465	99	3	tested	test	VERB
admet-1465	99	4	in	in	ADP
admet-1465	99	5	each	each	DET
admet-1465	99	6	experiment	experiment	NOUN
admet-1465	99	7	in	in	ADP
admet-1465	99	8	triplicates	triplicate	NOUN
admet-1465	99	9	at	at	ADP
admet-1465	99	10	least	least	ADJ
admet-1465	99	11	.	.	PUNCT
admet-1465	100	1	dialysis	dialysis	NOUN
admet-1465	100	2	bags	bag	NOUN
admet-1465	100	3	were	be	AUX
admet-1465	100	4	sealed	seal	VERB
admet-1465	100	5	at	at	ADP
admet-1465	100	6	one	one	NUM
admet-1465	100	7	end	end	NOUN
admet-1465	100	8	with	with	ADP
admet-1465	100	9	a	a	DET
admet-1465	100	10	weighted	weighted	ADJ
admet-1465	100	11	pin	pin	NOUN
admet-1465	100	12	and	and	CCONJ
admet-1465	100	13	1	1	NUM
admet-1465	100	14	ml	ml	NOUN
admet-1465	100	15	of	of	ADP
admet-1465	100	16	the	the	DET
admet-1465	100	17	formulation	formulation	NOUN
admet-1465	100	18	was	be	AUX
admet-1465	100	19	added	add	VERB
admet-1465	100	20	.	.	PUNCT
admet-1465	101	1	they	they	PRON
admet-1465	101	2	were	be	AUX
admet-1465	101	3	later	later	ADV
admet-1465	101	4	carefully	carefully	ADV
admet-1465	101	5	pinned	pin	VERB
admet-1465	101	6	on	on	ADP
admet-1465	101	7	the	the	DET
admet-1465	101	8	other	other	ADJ
admet-1465	101	9	side	side	NOUN
admet-1465	101	10	without	without	ADP
admet-1465	101	11	trapping	trap	VERB
admet-1465	101	12	air	air	NOUN
admet-1465	101	13	bubbles	bubble	NOUN
admet-1465	101	14	inside	inside	ADP
admet-1465	101	15	the	the	DET
admet-1465	101	16	bags	bag	NOUN
admet-1465	101	17	.	.	PUNCT
admet-1465	102	1	absorbance	absorbance	NOUN
admet-1465	102	2	measurements	measurement	NOUN
admet-1465	102	3	were	be	AUX
admet-1465	102	4	performed	perform	VERB
admet-1465	102	5	at	at	ADP
admet-1465	102	6	5	5	NUM
admet-1465	102	7	,	,	PUNCT
admet-1465	102	8	10	10	NUM
admet-1465	102	9	,	,	PUNCT
admet-1465	102	10	15	15	NUM
admet-1465	102	11	,	,	PUNCT
admet-1465	102	12	20	20	NUM
admet-1465	102	13	,	,	PUNCT
admet-1465	102	14	30	30	NUM
admet-1465	102	15	,	,	PUNCT
admet-1465	102	16	45	45	NUM
admet-1465	102	17	,	,	PUNCT
admet-1465	102	18	60	60	NUM
admet-1465	102	19	,	,	PUNCT
admet-1465	102	20	90	90	NUM
admet-1465	102	21	,	,	PUNCT
admet-1465	102	22	120	120	NUM
admet-1465	102	23	,	,	PUNCT
admet-1465	102	24	150	150	NUM
admet-1465	102	25	,	,	PUNCT
admet-1465	102	26	180	180	NUM
admet-1465	102	27	,	,	PUNCT
admet-1465	102	28	240	240	NUM
admet-1465	102	29	,	,	PUNCT
admet-1465	102	30	300	300	NUM
admet-1465	102	31	,	,	PUNCT
admet-1465	102	32	360	360	NUM
admet-1465	102	33	,	,	PUNCT
admet-1465	102	34	720	720	NUM
admet-1465	102	35	and	and	CCONJ
admet-1465	102	36	1440	1440	NUM
admet-1465	102	37	minutes	minute	NOUN
admet-1465	102	38	to	to	PART
admet-1465	102	39	determine	determine	VERB
admet-1465	102	40	the	the	DET
admet-1465	102	41	drug	drug	NOUN
admet-1465	102	42	dissolution	dissolution	NOUN
admet-1465	102	43	profile	profile	NOUN
admet-1465	102	44	at	at	ADP
admet-1465	102	45	given	give	VERB
admet-1465	102	46	parameters	parameter	NOUN
admet-1465	102	47	during	during	ADP
admet-1465	102	48	the	the	DET
admet-1465	102	49	method	method	NOUN
admet-1465	102	50	development	development	NOUN
admet-1465	102	51	.	.	PUNCT
admet-1465	103	1	for	for	ADP
admet-1465	103	2	further	further	ADJ
admet-1465	103	3	studies	study	NOUN
admet-1465	103	4	,	,	PUNCT
admet-1465	103	5	additional	additional	ADJ
admet-1465	103	6	sampling	sampling	NOUN
admet-1465	103	7	was	be	AUX
admet-1465	103	8	performed	perform	VERB
admet-1465	103	9	every	every	DET
admet-1465	103	10	12	12	NUM
admet-1465	103	11	hours	hour	NOUN
admet-1465	103	12	up	up	ADP
admet-1465	103	13	to	to	ADP
admet-1465	103	14	a	a	DET
admet-1465	103	15	maximum	maximum	NOUN
admet-1465	103	16	of	of	ADP
admet-1465	103	17	72	72	NUM
admet-1465	103	18	hours	hour	NOUN
admet-1465	103	19	.	.	PUNCT
admet-1465	104	1	as	as	ADP
admet-1465	104	2	a	a	DET
admet-1465	104	3	part	part	NOUN
admet-1465	104	4	of	of	ADP
admet-1465	104	5	the	the	DET
admet-1465	104	6	development	development	NOUN
admet-1465	104	7	of	of	ADP
admet-1465	104	8	the	the	DET
admet-1465	104	9	optimal	optimal	ADJ
admet-1465	104	10	dissolution	dissolution	NOUN
admet-1465	104	11	method	method	NOUN
admet-1465	104	12	,	,	PUNCT
admet-1465	104	13	sensitivity	sensitivity	NOUN
admet-1465	104	14	to	to	ADP
admet-1465	104	15	several	several	ADJ
admet-1465	104	16	parameters	parameter	NOUN
admet-1465	104	17	was	be	AUX
admet-1465	104	18	tested	test	VERB
admet-1465	104	19	:	:	PUNCT
admet-1465	104	20	type	type	NOUN
admet-1465	104	21	of	of	ADP
admet-1465	104	22	dialysis	dialysis	NOUN
admet-1465	104	23	membrane	membrane	NOUN
admet-1465	104	24	,	,	PUNCT
admet-1465	104	25	temperature	temperature	NOUN
admet-1465	104	26	,	,	PUNCT
admet-1465	104	27	release	release	VERB
admet-1465	104	28	medium	medium	ADJ
admet-1465	104	29	,	,	PUNCT
admet-1465	104	30	stirring	stir	VERB
admet-1465	104	31	rate	rate	NOUN
admet-1465	104	32	,	,	PUNCT
admet-1465	104	33	the	the	DET
admet-1465	104	34	composition	composition	NOUN
admet-1465	104	35	of	of	ADP
admet-1465	104	36	the	the	DET
admet-1465	104	37	release	release	NOUN
admet-1465	104	38	medium	medium	NOUN
admet-1465	104	39	,	,	PUNCT
admet-1465	104	40	and	and	CCONJ
admet-1465	104	41	test	test	NOUN
admet-1465	104	42	solution	solution	NOUN
admet-1465	104	43	volume	volume	NOUN
admet-1465	104	44	.	.	PUNCT
admet-1465	105	1	results	result	NOUN
admet-1465	105	2	and	and	CCONJ
admet-1465	105	3	discussion	discussion	NOUN
admet-1465	105	4	solubility	solubility	NOUN
admet-1465	105	5	solubility	solubility	NOUN
admet-1465	105	6	of	of	ADP
admet-1465	105	7	dex	dex	NOUN
admet-1465	105	8	was	be	AUX
admet-1465	105	9	determined	determine	VERB
admet-1465	105	10	in	in	ADP
admet-1465	105	11	five	five	NUM
admet-1465	105	12	oils	oil	NOUN
admet-1465	105	13	(	(	PUNCT
admet-1465	105	14	solvents	solvent	NOUN
admet-1465	105	15	)	)	PUNCT
admet-1465	105	16	and	and	CCONJ
admet-1465	105	17	mixtures	mixture	NOUN
admet-1465	105	18	with	with	ADP
admet-1465	105	19	10	10	NUM
admet-1465	105	20	or	or	CCONJ
admet-1465	105	21	20	20	NUM
admet-1465	105	22	%	%	NOUN
admet-1465	105	23	(	(	PUNCT
admet-1465	105	24	v	v	NOUN
admet-1465	105	25	/	/	SYM
admet-1465	105	26	v	v	NOUN
admet-1465	105	27	)	)	PUNCT
admet-1465	105	28	of	of	ADP
admet-1465	105	29	one	one	NUM
admet-1465	105	30	of	of	ADP
admet-1465	105	31	the	the	DET
admet-1465	105	32	cosolvents	cosolvent	NOUN
admet-1465	105	33	(	(	PUNCT
admet-1465	105	34	isopropanol	isopropanol	NOUN
admet-1465	105	35	or	or	CCONJ
admet-1465	105	36	capryol	capryol	NOUN
admet-1465	105	37	®	®	NOUN
admet-1465	105	38	90	90	NUM
admet-1465	105	39	)	)	PUNCT
admet-1465	105	40	.	.	PUNCT
admet-1465	106	1	evaluated	evaluate	VERB
admet-1465	106	2	oils	oil	NOUN
admet-1465	106	3	are	be	AUX
admet-1465	106	4	commonly	commonly	ADV
admet-1465	106	5	used	use	VERB
admet-1465	106	6	as	as	ADP
admet-1465	106	7	carriers	carrier	NOUN
admet-1465	106	8	for	for	ADP
admet-1465	106	9	parenteral	parenteral	ADJ
admet-1465	106	10	oil	oil	NOUN
admet-1465	106	11	depots	depot	NOUN
admet-1465	106	12	,	,	PUNCT
admet-1465	106	13	while	while	SCONJ
admet-1465	106	14	selected	select	VERB
admet-1465	106	15	cosolvents	cosolvent	NOUN
admet-1465	106	16	serve	serve	VERB
admet-1465	106	17	as	as	ADP
admet-1465	106	18	model	model	NOUN
admet-1465	106	19	type	type	NOUN
admet-1465	106	20	of	of	ADP
admet-1465	106	21	excipients	excipient	NOUN
admet-1465	106	22	that	that	PRON
admet-1465	106	23	can	can	AUX
admet-1465	106	24	increase	increase	VERB
admet-1465	106	25	the	the	DET
admet-1465	106	26	solubility	solubility	NOUN
admet-1465	106	27	of	of	ADP
admet-1465	106	28	the	the	DET
admet-1465	106	29	drug	drug	NOUN
admet-1465	106	30	in	in	ADP
admet-1465	106	31	selected	select	VERB
admet-1465	106	32	oil	oil	NOUN
admet-1465	106	33	in	in	ADP
admet-1465	106	34	order	order	NOUN
admet-1465	106	35	to	to	PART
admet-1465	106	36	achieve	achieve	VERB
admet-1465	106	37	model	model	NOUN
admet-1465	106	38	drug	drug	NOUN
admet-1465	106	39	therapeutic	therapeutic	ADJ
admet-1465	106	40	concentrations	concentration	NOUN
admet-1465	106	41	and	and	CCONJ
admet-1465	106	42	obtain	obtain	VERB
admet-1465	106	43	satisfactory	satisfactory	ADJ
admet-1465	106	44	partitioning	partitioning	NOUN
admet-1465	106	45	for	for	ADP
admet-1465	106	46	prolonged	prolonged	ADJ
admet-1465	106	47	release	release	NOUN
admet-1465	106	48	.	.	PUNCT
admet-1465	107	1	no	no	DET
admet-1465	107	2	significant	significant	ADJ
admet-1465	107	3	differences	difference	NOUN
admet-1465	107	4	in	in	ADP
admet-1465	107	5	solubility	solubility	NOUN
admet-1465	107	6	were	be	AUX
admet-1465	107	7	observed	observe	VERB
admet-1465	107	8	between	between	ADP
admet-1465	107	9	2	2	NUM
admet-1465	107	10	and	and	CCONJ
admet-1465	107	11	24	24	NUM
admet-1465	107	12	hours	hour	NOUN
admet-1465	107	13	of	of	ADP
admet-1465	107	14	incubation	incubation	NOUN
admet-1465	107	15	,	,	PUNCT
admet-1465	107	16	indicating	indicate	VERB
admet-1465	107	17	that	that	SCONJ
admet-1465	107	18	the	the	DET
admet-1465	107	19	equilibrium	equilibrium	NOUN
admet-1465	107	20	occurs	occur	VERB
admet-1465	107	21	quickly	quickly	ADV
admet-1465	107	22	after	after	ADP
admet-1465	107	23	the	the	DET
admet-1465	107	24	addition	addition	NOUN
admet-1465	107	25	of	of	ADP
admet-1465	107	26	dex	dex	NOUN
admet-1465	107	27	to	to	ADP
admet-1465	107	28	the	the	DET
admet-1465	107	29	solvent	solvent	ADJ
admet-1465	107	30	mixtures	mixture	NOUN
admet-1465	107	31	.	.	PUNCT
admet-1465	108	1	therefore	therefore	ADV
admet-1465	108	2	,	,	PUNCT
admet-1465	108	3	only	only	ADV
admet-1465	108	4	the	the	DET
admet-1465	108	5	results	result	NOUN
admet-1465	108	6	for	for	ADP
admet-1465	108	7	solubility	solubility	NOUN
admet-1465	108	8	after	after	ADP
admet-1465	108	9	24	24	NUM
admet-1465	108	10	hours	hour	NOUN
admet-1465	108	11	are	be	AUX
admet-1465	108	12	shown	show	VERB
admet-1465	108	13	(	(	PUNCT
admet-1465	108	14	figure	figure	NOUN
admet-1465	108	15	1	1	NUM
admet-1465	108	16	)	)	PUNCT
admet-1465	108	17	.	.	PUNCT
admet-1465	109	1	figure	figure	NOUN
admet-1465	109	2	1	1	NUM
admet-1465	109	3	.	.	PUNCT
admet-1465	110	1	solubility	solubility	NOUN
admet-1465	110	2	of	of	ADP
admet-1465	110	3	dex	dex	NOUN
admet-1465	110	4	after	after	ADP
admet-1465	110	5	24	24	NUM
admet-1465	110	6	hours	hour	NOUN
admet-1465	110	7	incubation	incubation	NOUN
admet-1465	110	8	in	in	ADP
admet-1465	110	9	various	various	ADJ
admet-1465	110	10	vegetable	vegetable	ADJ
admet-1465	110	11	oils	oil	NOUN
admet-1465	110	12	alone	alone	ADJ
admet-1465	110	13	and	and	CCONJ
admet-1465	110	14	with	with	ADP
admet-1465	110	15	the	the	DET
admet-1465	110	16	addition	addition	NOUN
admet-1465	110	17	of	of	ADP
admet-1465	110	18	cosolvents	cosolvent	NOUN
admet-1465	110	19	(	(	PUNCT
admet-1465	110	20	capryol	capryol	NOUN
admet-1465	110	21	®	®	NOUN
admet-1465	110	22	90	90	NUM
admet-1465	110	23	(	(	PUNCT
admet-1465	110	24	blue	blue	ADJ
admet-1465	110	25	bars	bar	NOUN
admet-1465	110	26	)	)	PUNCT
admet-1465	110	27	or	or	CCONJ
admet-1465	110	28	isopropanol	isopropanol	NOUN
admet-1465	110	29	(	(	PUNCT
admet-1465	110	30	orange	orange	NOUN
admet-1465	110	31	bars	bar	NOUN
admet-1465	110	32	)	)	PUNCT
admet-1465	110	33	at	at	ADP
admet-1465	110	34	10	10	NUM
admet-1465	110	35	%	%	NOUN
admet-1465	110	36	or	or	CCONJ
admet-1465	110	37	20	20	NUM
admet-1465	110	38	%	%	NOUN
admet-1465	110	39	(	(	PUNCT
admet-1465	110	40	v	v	NOUN
admet-1465	110	41	/	/	SYM
admet-1465	110	42	v	v	NOUN
admet-1465	110	43	)	)	PUNCT
admet-1465	110	44	)	)	PUNCT
admet-1465	110	45	.	.	PUNCT
admet-1465	111	1	error	error	NOUN
admet-1465	111	2	bars	bar	NOUN
admet-1465	111	3	represent	represent	VERB
admet-1465	111	4	standard	standard	ADJ
admet-1465	111	5	deviation	deviation	NOUN
admet-1465	111	6	,	,	PUNCT
admet-1465	111	7	n=3	n=3	NOUN
admet-1465	111	8	.	.	X
admet-1465	112	1	dex	dex	NOUN
admet-1465	112	2	did	do	AUX
admet-1465	112	3	not	not	PART
admet-1465	112	4	show	show	VERB
admet-1465	112	5	high	high	ADJ
admet-1465	112	6	solubility	solubility	NOUN
admet-1465	112	7	in	in	ADP
admet-1465	112	8	pure	pure	ADJ
admet-1465	112	9	vegetable	vegetable	ADJ
admet-1465	112	10	oils	oil	NOUN
admet-1465	112	11	,	,	PUNCT
admet-1465	112	12	except	except	SCONJ
admet-1465	112	13	for	for	ADP
admet-1465	112	14	castor	castor	NOUN
admet-1465	112	15	oil	oil	NOUN
admet-1465	112	16	.	.	PUNCT
admet-1465	113	1	the	the	DET
admet-1465	113	2	composition	composition	NOUN
admet-1465	113	3	of	of	ADP
admet-1465	113	4	triglycerides	triglyceride	NOUN
admet-1465	113	5	in	in	ADP
admet-1465	113	6	corn	corn	NOUN
admet-1465	113	7	,	,	PUNCT
admet-1465	113	8	cottonseed	cottonseed	NOUN
admet-1465	113	9	,	,	PUNCT
admet-1465	113	10	sesame	sesame	NOUN
admet-1465	113	11	and	and	CCONJ
admet-1465	113	12	peanut	peanut	NOUN
admet-1465	113	13	oil	oil	NOUN
admet-1465	113	14	is	be	AUX
admet-1465	113	15	very	very	ADV
admet-1465	113	16	similar	similar	ADJ
admet-1465	113	17	and	and	CCONJ
admet-1465	113	18	the	the	DET
admet-1465	113	19	fatty	fatty	NOUN
admet-1465	113	20	acid	acid	NOUN
admet-1465	113	21	moieties	moiety	NOUN
admet-1465	113	22	mostly	mostly	ADV
admet-1465	113	23	come	come	VERB
admet-1465	113	24	from	from	ADP
admet-1465	113	25	oleic	oleic	NOUN
admet-1465	113	26	and	and	CCONJ
admet-1465	113	27	linoleic	linoleic	ADJ
admet-1465	113	28	acid	acid	NOUN
admet-1465	113	29	.	.	PUNCT
admet-1465	114	1	castor	castor	NOUN
admet-1465	114	2	oil	oil	NOUN
admet-1465	114	3	is	be	AUX
admet-1465	114	4	much	much	ADV
admet-1465	114	5	more	more	ADV
admet-1465	114	6	hydrophilic	hydrophilic	ADJ
admet-1465	114	7	due	due	ADP
admet-1465	114	8	to	to	ADP
admet-1465	114	9	the	the	DET
admet-1465	114	10	high	high	ADJ
admet-1465	114	11	content	content	NOUN
admet-1465	114	12	(	(	PUNCT
admet-1465	114	13	about	about	ADV
admet-1465	114	14	90	90	NUM
admet-1465	114	15	%	%	NOUN
admet-1465	114	16	)	)	PUNCT
admet-1465	114	17	of	of	ADP
admet-1465	114	18	ricinoleic	ricinoleic	VERB
admet-1465	114	19	acid	acid	NOUN
admet-1465	114	20	residues	residue	NOUN
admet-1465	114	21	amongst	amongst	ADP
admet-1465	114	22	the	the	DET
admet-1465	114	23	triglycerides	triglyceride	NOUN
admet-1465	114	24	.	.	PUNCT
admet-1465	115	1	ricinoleic	ricinoleic	PROPN
admet-1465	115	2	acid	acid	PROPN
admet-1465	115	3	contains	contain	VERB
admet-1465	115	4	one	one	NUM
admet-1465	115	5	hydroxyl	hydroxyl	NOUN
admet-1465	115	6	group	group	NOUN
admet-1465	115	7	,	,	PUNCT
admet-1465	115	8	which	which	PRON
admet-1465	115	9	enables	enable	VERB
admet-1465	115	10	hydrogen	hydrogen	NOUN
admet-1465	115	11	bonding	bonding	NOUN
admet-1465	115	12	with	with	ADP
admet-1465	115	13	dex	dex	NOUN
admet-1465	115	14	's	's	PART
admet-1465	115	15	h	h	NOUN
admet-1465	115	16	-	-	PUNCT
admet-1465	115	17	bond	bond	NOUN
admet-1465	115	18	acceptor	acceptor	NOUN
admet-1465	115	19	groups	group	NOUN
admet-1465	115	20	[	[	X
admet-1465	115	21	20	20	NUM
admet-1465	115	22	]	]	PUNCT
admet-1465	115	23	.	.	PUNCT
admet-1465	116	1	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	116	2	filip	filip	PROPN
admet-1465	116	3	kozlina	kozlina	PROPN
admet-1465	116	4	et	et	PROPN
admet-1465	116	5	al	al	PROPN
admet-1465	116	6	.	.	PROPN
admet-1465	116	7	admet	admet	PROPN
admet-1465	116	8	&	&	CCONJ
admet-1465	116	9	dmpk	dmpk	PROPN
admet-1465	116	10	10(4	10(4	NUM
admet-1465	116	11	)	)	PUNCT
admet-1465	116	12	(	(	PUNCT
admet-1465	116	13	2022	2022	NUM
admet-1465	116	14	)	)	PUNCT
admet-1465	116	15	315	315	NUM
admet-1465	116	16	-	-	SYM
admet-1465	116	17	329	329	NUM
admet-1465	116	18	320	320	NUM
admet-1465	116	19	cosolvent	cosolvent	ADJ
admet-1465	116	20	addition	addition	NOUN
admet-1465	116	21	clearly	clearly	ADV
admet-1465	116	22	made	make	VERB
admet-1465	116	23	a	a	DET
admet-1465	116	24	significant	significant	ADJ
admet-1465	116	25	impact	impact	NOUN
admet-1465	116	26	on	on	ADP
admet-1465	116	27	the	the	DET
admet-1465	116	28	solubility	solubility	NOUN
admet-1465	116	29	of	of	ADP
admet-1465	116	30	dex	dex	NOUN
admet-1465	116	31	.	.	PUNCT
admet-1465	117	1	solubility	solubility	NOUN
admet-1465	117	2	greatly	greatly	ADV
admet-1465	117	3	increased	increase	VERB
admet-1465	117	4	with	with	ADP
admet-1465	117	5	the	the	DET
admet-1465	117	6	addition	addition	NOUN
admet-1465	117	7	of	of	ADP
admet-1465	117	8	10	10	NUM
admet-1465	117	9	%	%	NOUN
admet-1465	117	10	(	(	PUNCT
admet-1465	117	11	v	v	NOUN
admet-1465	117	12	/	/	SYM
admet-1465	117	13	v	v	NOUN
admet-1465	117	14	)	)	PUNCT
admet-1465	117	15	of	of	ADP
admet-1465	117	16	both	both	DET
admet-1465	117	17	cosolvents	cosolvent	NOUN
admet-1465	117	18	and	and	CCONJ
admet-1465	117	19	increased	increase	VERB
admet-1465	117	20	with	with	ADP
admet-1465	117	21	the	the	DET
admet-1465	117	22	20	20	NUM
admet-1465	117	23	%	%	NOUN
admet-1465	117	24	(	(	PUNCT
admet-1465	117	25	v	v	NOUN
admet-1465	117	26	/	/	SYM
admet-1465	117	27	v	v	NOUN
admet-1465	117	28	)	)	PUNCT
admet-1465	117	29	concentrations	concentration	NOUN
admet-1465	117	30	.	.	PUNCT
admet-1465	118	1	dex	dex	PROPN
admet-1465	118	2	was	be	AUX
admet-1465	118	3	more	more	ADV
admet-1465	118	4	soluble	soluble	ADJ
admet-1465	118	5	in	in	ADP
admet-1465	118	6	isopropanol	isopropanol	NOUN
admet-1465	118	7	than	than	ADP
admet-1465	118	8	capryol	capryol	NOUN
admet-1465	118	9	®	®	NOUN
admet-1465	118	10	90	90	NUM
admet-1465	118	11	solutions	solution	NOUN
admet-1465	118	12	,	,	PUNCT
admet-1465	118	13	which	which	PRON
admet-1465	118	14	was	be	AUX
admet-1465	118	15	expected	expect	VERB
admet-1465	118	16	due	due	ADP
admet-1465	118	17	to	to	ADP
admet-1465	118	18	the	the	DET
admet-1465	118	19	hydrophilic	hydrophilic	ADJ
admet-1465	118	20	nature	nature	NOUN
admet-1465	118	21	of	of	ADP
admet-1465	118	22	isopropanol	isopropanol	NOUN
admet-1465	118	23	.	.	PUNCT
admet-1465	119	1	the	the	DET
admet-1465	119	2	highest	high	ADJ
admet-1465	119	3	solubility	solubility	NOUN
admet-1465	119	4	of	of	ADP
admet-1465	119	5	dex	dex	NOUN
admet-1465	119	6	was	be	AUX
admet-1465	119	7	achieved	achieve	VERB
admet-1465	119	8	in	in	ADP
admet-1465	119	9	castor	castor	NOUN
admet-1465	119	10	oil	oil	NOUN
admet-1465	119	11	solution	solution	NOUN
admet-1465	119	12	with	with	ADP
admet-1465	119	13	20	20	NUM
admet-1465	119	14	%	%	NOUN
admet-1465	119	15	(	(	PUNCT
admet-1465	119	16	v	v	NOUN
admet-1465	119	17	/	/	SYM
admet-1465	119	18	v	v	NOUN
admet-1465	119	19	)	)	PUNCT
admet-1465	119	20	of	of	ADP
admet-1465	119	21	isopropanol	isopropanol	NOUN
admet-1465	119	22	(	(	PUNCT
admet-1465	119	23	around	around	ADP
admet-1465	119	24	2.3	2.3	NUM
admet-1465	119	25	mg	mg	NUM
admet-1465	119	26	/	/	SYM
admet-1465	119	27	ml	ml	NOUN
admet-1465	119	28	)	)	PUNCT
admet-1465	119	29	and	and	CCONJ
admet-1465	119	30	20	20	NUM
admet-1465	119	31	%	%	NOUN
admet-1465	119	32	(	(	PUNCT
admet-1465	119	33	v	v	NOUN
admet-1465	119	34	/	/	SYM
admet-1465	119	35	v	v	NOUN
admet-1465	119	36	)	)	PUNCT
admet-1465	119	37	capryol	capryol	NOUN
admet-1465	119	38	®	®	NOUN
admet-1465	119	39	90	90	NUM
admet-1465	119	40	(	(	PUNCT
admet-1465	119	41	around	around	ADP
admet-1465	119	42	1.2	1.2	NUM
admet-1465	119	43	mg	mg	NUM
admet-1465	119	44	/	/	SYM
admet-1465	119	45	ml	ml	NOUN
admet-1465	119	46	)	)	PUNCT
admet-1465	119	47	.	.	PUNCT
admet-1465	120	1	based	base	VERB
admet-1465	120	2	on	on	ADP
admet-1465	120	3	the	the	DET
admet-1465	120	4	results	result	NOUN
admet-1465	120	5	of	of	ADP
admet-1465	120	6	the	the	DET
admet-1465	120	7	solubility	solubility	NOUN
admet-1465	120	8	study	study	NOUN
admet-1465	120	9	,	,	PUNCT
admet-1465	120	10	test	test	NOUN
admet-1465	120	11	solutions	solution	NOUN
admet-1465	120	12	with	with	ADP
admet-1465	120	13	castor	castor	NOUN
admet-1465	120	14	oil	oil	NOUN
admet-1465	120	15	as	as	ADP
admet-1465	120	16	a	a	DET
admet-1465	120	17	solvent	solvent	NOUN
admet-1465	120	18	with	with	ADP
admet-1465	120	19	the	the	DET
admet-1465	120	20	addition	addition	NOUN
admet-1465	120	21	of	of	ADP
admet-1465	120	22	20	20	NUM
admet-1465	120	23	%	%	NOUN
admet-1465	120	24	(	(	PUNCT
admet-1465	120	25	v	v	NOUN
admet-1465	120	26	/	/	SYM
admet-1465	120	27	v	v	NOUN
admet-1465	120	28	)	)	PUNCT
admet-1465	120	29	of	of	ADP
admet-1465	120	30	one	one	NUM
admet-1465	120	31	of	of	ADP
admet-1465	120	32	the	the	DET
admet-1465	120	33	cosolvents	cosolvent	NOUN
admet-1465	120	34	were	be	AUX
admet-1465	120	35	used	use	VERB
admet-1465	120	36	for	for	ADP
admet-1465	120	37	partitioning	partition	VERB
admet-1465	120	38	and	and	CCONJ
admet-1465	120	39	ivr	ivr	PROPN
admet-1465	120	40	experiments	experiment	NOUN
admet-1465	120	41	.	.	PUNCT
admet-1465	121	1	partitioning	partition	VERB
admet-1465	121	2	determination	determination	NOUN
admet-1465	121	3	of	of	ADP
admet-1465	121	4	the	the	DET
admet-1465	121	5	partition	partition	NOUN
admet-1465	121	6	coefficient	coefficient	NOUN
admet-1465	121	7	is	be	AUX
admet-1465	121	8	very	very	ADV
admet-1465	121	9	helpful	helpful	ADJ
admet-1465	121	10	for	for	ADP
admet-1465	121	11	the	the	DET
admet-1465	121	12	prediction	prediction	NOUN
admet-1465	121	13	of	of	ADP
admet-1465	121	14	the	the	DET
admet-1465	121	15	behaviour	behaviour	NOUN
admet-1465	121	16	of	of	ADP
admet-1465	121	17	prolongedrelease	prolongedrelease	NOUN
admet-1465	121	18	formulations	formulation	NOUN
admet-1465	121	19	in	in	ADP
admet-1465	121	20	vivo	vivo	NOUN
admet-1465	121	21	.	.	PUNCT
admet-1465	122	1	partition	partition	NOUN
admet-1465	122	2	coefficients	coefficient	NOUN
admet-1465	122	3	determined	determined	ADJ
admet-1465	122	4	for	for	ADP
admet-1465	122	5	the	the	DET
admet-1465	122	6	chosen	choose	VERB
admet-1465	122	7	test	test	NOUN
admet-1465	122	8	solutions	solution	NOUN
admet-1465	122	9	with	with	ADP
admet-1465	122	10	the	the	DET
admet-1465	122	11	phosphate	phosphate	ADJ
admet-1465	122	12	buffer	buffer	NOUN
admet-1465	122	13	ph	ph	VERB
admet-1465	122	14	7.4	7.4	NUM
admet-1465	122	15	(	(	PUNCT
admet-1465	122	16	later	later	ADV
admet-1465	122	17	used	use	VERB
admet-1465	122	18	as	as	ADP
admet-1465	122	19	a	a	DET
admet-1465	122	20	release	release	NOUN
admet-1465	122	21	medium	medium	NOUN
admet-1465	122	22	)	)	PUNCT
admet-1465	122	23	as	as	SCONJ
admet-1465	122	24	the	the	DET
admet-1465	122	25	aqueous	aqueous	ADJ
admet-1465	122	26	phase	phase	NOUN
admet-1465	122	27	are	be	AUX
admet-1465	122	28	shown	show	VERB
admet-1465	122	29	in	in	ADP
admet-1465	122	30	table	table	NOUN
admet-1465	122	31	1	1	NUM
admet-1465	122	32	.	.	PUNCT
admet-1465	123	1	log	log	VERB
admet-1465	123	2	p	p	NOUN
admet-1465	123	3	value	value	NOUN
admet-1465	123	4	higher	high	ADJ
admet-1465	123	5	than	than	SCONJ
admet-1465	123	6	1	1	NUM
admet-1465	123	7	was	be	AUX
admet-1465	123	8	obtained	obtain	VERB
admet-1465	123	9	(	(	PUNCT
admet-1465	123	10	1.25	1.25	NUM
admet-1465	123	11	for	for	ADP
admet-1465	123	12	the	the	DET
admet-1465	123	13	isopropanol	isopropanol	NOUN
admet-1465	123	14	formulation	formulation	NOUN
admet-1465	123	15	and	and	CCONJ
admet-1465	123	16	1.53	1.53	NUM
admet-1465	123	17	for	for	ADP
admet-1465	123	18	capryol	capryol	NOUN
admet-1465	123	19	®	®	NOUN
admet-1465	123	20	90	90	NUM
admet-1465	123	21	formulation	formulation	NOUN
admet-1465	123	22	)	)	PUNCT
admet-1465	123	23	,	,	PUNCT
admet-1465	123	24	indicating	indicate	VERB
admet-1465	123	25	that	that	SCONJ
admet-1465	123	26	the	the	DET
admet-1465	123	27	formulations	formulation	NOUN
admet-1465	123	28	could	could	AUX
admet-1465	123	29	achieve	achieve	VERB
admet-1465	123	30	prolonged	prolonged	ADJ
admet-1465	123	31	release	release	NOUN
admet-1465	123	32	.	.	PUNCT
admet-1465	124	1	furthermore	furthermore	ADV
admet-1465	124	2	,	,	PUNCT
admet-1465	124	3	it	it	PRON
admet-1465	124	4	took	take	VERB
admet-1465	124	5	24	24	NUM
admet-1465	124	6	hours	hour	NOUN
admet-1465	124	7	of	of	ADP
admet-1465	124	8	stirring	stirring	NOUN
admet-1465	124	9	for	for	ADP
admet-1465	124	10	the	the	DET
admet-1465	124	11	isopropanol	isopropanol	NOUN
admet-1465	124	12	test	test	NOUN
admet-1465	124	13	solution	solution	NOUN
admet-1465	124	14	to	to	PART
admet-1465	124	15	achieve	achieve	VERB
admet-1465	124	16	equilibrium	equilibrium	NOUN
admet-1465	124	17	,	,	PUNCT
admet-1465	124	18	while	while	SCONJ
admet-1465	124	19	the	the	DET
admet-1465	124	20	capryol	capryol	NOUN
admet-1465	124	21	®	®	NOUN
admet-1465	124	22	90	90	NUM
admet-1465	124	23	test	test	NOUN
admet-1465	124	24	solution	solution	NOUN
admet-1465	124	25	achieved	achieve	VERB
admet-1465	124	26	equilibrium	equilibrium	NOUN
admet-1465	124	27	much	much	ADV
admet-1465	124	28	earlier	early	ADV
admet-1465	124	29	.	.	PUNCT
admet-1465	125	1	table	table	NOUN
admet-1465	125	2	1	1	NUM
admet-1465	125	3	.	.	PUNCT
admet-1465	125	4	results	result	NOUN
admet-1465	125	5	of	of	ADP
admet-1465	125	6	partitioning	partition	VERB
admet-1465	125	7	study	study	NOUN
admet-1465	125	8	for	for	ADP
admet-1465	125	9	dex	dex	NOUN
admet-1465	125	10	test	test	NOUN
admet-1465	125	11	solutions	solution	NOUN
admet-1465	125	12	(	(	PUNCT
admet-1465	125	13	sd	sd	NOUN
admet-1465	125	14	–	–	PUNCT
admet-1465	125	15	standard	standard	ADJ
admet-1465	125	16	deviation	deviation	NOUN
admet-1465	125	17	,	,	PUNCT
admet-1465	125	18	n=3	n=3	NOUN
admet-1465	125	19	)	)	PUNCT
admet-1465	125	20	.	.	PUNCT
admet-1465	126	1	dex	dex	NOUN
admet-1465	126	2	conc	conc	PROPN
admet-1465	126	3	.	.	PUNCT
admet-1465	127	1	ratio	ratio	NOUN
admet-1465	127	2	(	(	PUNCT
admet-1465	127	3	oil	oil	NOUN
admet-1465	127	4	/aqueous	/aqueous	ADJ
admet-1465	127	5	phase	phase	NOUN
admet-1465	127	6	)	)	PUNCT
admet-1465	127	7	cosolvent	cosolvent	NOUN
admet-1465	127	8	t	t	PROPN
admet-1465	127	9	/	/	SYM
admet-1465	127	10	h	h	NOUN
admet-1465	127	11	mean	mean	NOUN
admet-1465	127	12	value	value	NOUN
admet-1465	127	13	sd	sd	NOUN
admet-1465	127	14	log	log	VERB
admet-1465	127	15	p	p	NOUN
admet-1465	127	16	isopropanol	isopropanol	NOUN
admet-1465	127	17	2	2	NUM
admet-1465	127	18	21.1	21.1	NUM
admet-1465	127	19	2.1	2.1	NUM
admet-1465	127	20	1.25	1.25	NUM
admet-1465	127	21	24	24	NUM
admet-1465	127	22	10.7	10.7	NUM
admet-1465	127	23	0.1	0.1	NUM
admet-1465	127	24	capryol	capryol	NOUN
admet-1465	127	25	®	®	NOUN
admet-1465	127	26	90	90	NUM
admet-1465	127	27	2	2	NUM
admet-1465	127	28	38.9	38.9	NUM
admet-1465	127	29	0.2	0.2	NUM
admet-1465	127	30	1.53	1.53	NUM
admet-1465	127	31	24	24	NUM
admet-1465	127	32	34.7	34.7	NUM
admet-1465	127	33	1.8	1.8	NUM
admet-1465	127	34	the	the	DET
admet-1465	127	35	appropriate	appropriate	ADJ
admet-1465	127	36	choice	choice	NOUN
admet-1465	127	37	of	of	ADP
admet-1465	127	38	the	the	DET
admet-1465	127	39	type	type	NOUN
admet-1465	127	40	and	and	CCONJ
admet-1465	127	41	concentration	concentration	NOUN
admet-1465	127	42	of	of	ADP
admet-1465	127	43	cosolvent	cosolvent	NOUN
admet-1465	127	44	used	use	VERB
admet-1465	127	45	in	in	ADP
admet-1465	127	46	prolonged	prolonged	ADJ
admet-1465	127	47	release	release	NOUN
admet-1465	127	48	parenteral	parenteral	ADJ
admet-1465	127	49	product	product	NOUN
admet-1465	127	50	is	be	AUX
admet-1465	127	51	reflected	reflect	VERB
admet-1465	127	52	in	in	ADP
admet-1465	127	53	both	both	CCONJ
admet-1465	127	54	solubility	solubility	NOUN
admet-1465	127	55	and	and	CCONJ
admet-1465	127	56	partition	partition	NOUN
admet-1465	127	57	coefficient	coefficient	NOUN
admet-1465	127	58	of	of	ADP
admet-1465	127	59	the	the	DET
admet-1465	127	60	drug	drug	NOUN
admet-1465	127	61	.	.	PUNCT
admet-1465	128	1	since	since	SCONJ
admet-1465	128	2	better	well	ADJ
admet-1465	128	3	solubility	solubility	NOUN
admet-1465	128	4	and	and	CCONJ
admet-1465	128	5	partitioning	partitioning	NOUN
admet-1465	128	6	of	of	ADP
admet-1465	128	7	dex	dex	NOUN
admet-1465	128	8	were	be	AUX
admet-1465	128	9	observed	observe	VERB
admet-1465	128	10	using	use	VERB
admet-1465	128	11	the	the	DET
admet-1465	128	12	formulation	formulation	NOUN
admet-1465	128	13	with	with	ADP
admet-1465	128	14	20	20	NUM
admet-1465	128	15	%	%	NOUN
admet-1465	128	16	(	(	PUNCT
admet-1465	128	17	v	v	NOUN
admet-1465	128	18	/	/	SYM
admet-1465	128	19	v	v	NOUN
admet-1465	128	20	)	)	PUNCT
admet-1465	128	21	cosolvent	cosolvent	NOUN
admet-1465	128	22	,	,	PUNCT
admet-1465	128	23	such	such	ADJ
admet-1465	128	24	test	test	NOUN
admet-1465	128	25	solutions	solution	NOUN
admet-1465	128	26	were	be	AUX
admet-1465	128	27	used	use	VERB
admet-1465	128	28	for	for	ADP
admet-1465	128	29	further	further	ADJ
admet-1465	128	30	ivr	ivr	PROPN
admet-1465	128	31	experiments	experiment	NOUN
admet-1465	128	32	.	.	PUNCT
admet-1465	129	1	higher	high	ADJ
admet-1465	129	2	concentrations	concentration	NOUN
admet-1465	129	3	of	of	ADP
admet-1465	129	4	cosolvents	cosolvent	NOUN
admet-1465	129	5	might	might	AUX
admet-1465	129	6	lead	lead	VERB
admet-1465	129	7	to	to	ADP
admet-1465	129	8	a	a	DET
admet-1465	129	9	significantly	significantly	ADV
admet-1465	129	10	lower	low	ADJ
admet-1465	129	11	partition	partition	NOUN
admet-1465	129	12	coefficient	coefficient	NOUN
admet-1465	129	13	,	,	PUNCT
admet-1465	129	14	which	which	PRON
admet-1465	129	15	could	could	AUX
admet-1465	129	16	,	,	PUNCT
admet-1465	129	17	in	in	ADP
admet-1465	129	18	turn	turn	NOUN
admet-1465	129	19	,	,	PUNCT
admet-1465	129	20	diminish	diminish	VERB
admet-1465	129	21	the	the	DET
admet-1465	129	22	prolonged	prolong	VERB
admet-1465	129	23	release	release	NOUN
admet-1465	129	24	properties	property	NOUN
admet-1465	129	25	of	of	ADP
admet-1465	129	26	the	the	DET
admet-1465	129	27	formulation	formulation	NOUN
admet-1465	129	28	.	.	PUNCT
admet-1465	130	1	in	in	ADP
admet-1465	130	2	vitro	vitro	X
admet-1465	130	3	release	release	NOUN
admet-1465	130	4	method	method	NOUN
admet-1465	130	5	development	development	NOUN
admet-1465	130	6	following	follow	VERB
admet-1465	130	7	preliminary	preliminary	ADJ
admet-1465	130	8	tests	test	NOUN
admet-1465	130	9	,	,	PUNCT
admet-1465	130	10	several	several	ADJ
admet-1465	130	11	test	test	NOUN
admet-1465	130	12	parameters	parameter	NOUN
admet-1465	130	13	were	be	AUX
admet-1465	130	14	varied	varied	ADJ
admet-1465	130	15	in	in	ADP
admet-1465	130	16	further	further	ADJ
admet-1465	130	17	method	method	NOUN
admet-1465	130	18	development	development	NOUN
admet-1465	130	19	in	in	ADP
admet-1465	130	20	order	order	NOUN
admet-1465	130	21	to	to	PART
admet-1465	130	22	determine	determine	VERB
admet-1465	130	23	the	the	DET
admet-1465	130	24	method	method	NOUN
admet-1465	130	25	’s	’s	PART
admet-1465	130	26	sensitivity	sensitivity	NOUN
admet-1465	130	27	and	and	CCONJ
admet-1465	130	28	optimal	optimal	ADJ
admet-1465	130	29	test	test	NOUN
admet-1465	130	30	conditions	condition	NOUN
admet-1465	130	31	.	.	PUNCT
admet-1465	131	1	dialysis	dialysis	NOUN
admet-1465	131	2	membranes	membrane	NOUN
admet-1465	131	3	during	during	ADP
admet-1465	131	4	the	the	DET
admet-1465	131	5	method	method	NOUN
admet-1465	131	6	development	development	NOUN
admet-1465	131	7	,	,	PUNCT
admet-1465	131	8	two	two	NUM
admet-1465	131	9	types	type	NOUN
admet-1465	131	10	of	of	ADP
admet-1465	131	11	dialysis	dialysis	NOUN
admet-1465	131	12	membranes	membrane	NOUN
admet-1465	131	13	were	be	AUX
admet-1465	131	14	inspected	inspect	VERB
admet-1465	131	15	,	,	PUNCT
admet-1465	131	16	ce	ce	PROPN
admet-1465	131	17	membranes	membrane	NOUN
admet-1465	131	18	with	with	ADP
admet-1465	131	19	mwco	mwco	NOUN
admet-1465	131	20	300	300	NUM
admet-1465	131	21	kda	kda	NOUN
admet-1465	131	22	and	and	CCONJ
admet-1465	131	23	rc	rc	PROPN
admet-1465	131	24	membranes	membrane	NOUN
admet-1465	131	25	with	with	ADP
admet-1465	131	26	mwco	mwco	PROPN
admet-1465	131	27	50	50	NUM
admet-1465	131	28	kda	kda	NOUN
admet-1465	131	29	.	.	PUNCT
admet-1465	132	1	when	when	SCONJ
admet-1465	132	2	comparing	compare	VERB
admet-1465	132	3	dexamethasone	dexamethasone	NOUN
admet-1465	132	4	release	release	NOUN
admet-1465	132	5	profiles	profile	NOUN
admet-1465	132	6	from	from	ADP
admet-1465	132	7	isopropanol	isopropanol	NOUN
admet-1465	132	8	and	and	CCONJ
admet-1465	132	9	capryol	capryol	NOUN
admet-1465	132	10	®	®	NOUN
admet-1465	132	11	90	90	NUM
admet-1465	132	12	containing	contain	VERB
admet-1465	132	13	formulations	formulation	NOUN
admet-1465	132	14	,	,	PUNCT
admet-1465	132	15	the	the	DET
admet-1465	132	16	great	great	ADJ
admet-1465	132	17	similarity	similarity	NOUN
admet-1465	132	18	was	be	AUX
admet-1465	132	19	observed	observe	VERB
admet-1465	132	20	when	when	SCONJ
admet-1465	132	21	ce	ce	PROPN
admet-1465	132	22	membranes	membrane	NOUN
admet-1465	132	23	were	be	AUX
admet-1465	132	24	used	use	VERB
admet-1465	132	25	,	,	PUNCT
admet-1465	132	26	while	while	SCONJ
admet-1465	132	27	a	a	DET
admet-1465	132	28	certain	certain	ADJ
admet-1465	132	29	difference	difference	NOUN
admet-1465	132	30	between	between	ADP
admet-1465	132	31	the	the	DET
admet-1465	132	32	profiles	profile	NOUN
admet-1465	132	33	was	be	AUX
admet-1465	132	34	noticeable	noticeable	ADJ
admet-1465	132	35	with	with	ADP
admet-1465	132	36	rc	rc	PROPN
admet-1465	132	37	membranes	membrane	NOUN
admet-1465	132	38	which	which	PRON
admet-1465	132	39	have	have	VERB
admet-1465	132	40	a	a	DET
admet-1465	132	41	smaller	small	ADJ
admet-1465	132	42	pore	pore	ADJ
admet-1465	132	43	size	size	NOUN
admet-1465	132	44	and	and	CCONJ
admet-1465	132	45	contact	contact	NOUN
admet-1465	132	46	area	area	NOUN
admet-1465	132	47	(	(	PUNCT
admet-1465	132	48	figure	figure	NOUN
admet-1465	132	49	2	2	NUM
admet-1465	132	50	)	)	PUNCT
admet-1465	132	51	.	.	PUNCT
admet-1465	133	1	since	since	SCONJ
admet-1465	133	2	the	the	DET
admet-1465	133	3	concentration	concentration	NOUN
admet-1465	133	4	of	of	ADP
admet-1465	133	5	dex	dex	NOUN
admet-1465	133	6	is	be	AUX
admet-1465	133	7	twofold	twofold	ADV
admet-1465	133	8	higher	high	ADJ
admet-1465	133	9	in	in	ADP
admet-1465	133	10	isopropanol	isopropanol	NOUN
admet-1465	133	11	compared	compare	VERB
admet-1465	133	12	to	to	AUX
admet-1465	133	13	capryol	capryol	VERB
admet-1465	133	14	®	®	NOUN
admet-1465	133	15	90	90	NUM
admet-1465	133	16	containing	contain	VERB
admet-1465	133	17	formulation	formulation	NOUN
admet-1465	133	18	,	,	PUNCT
admet-1465	133	19	the	the	DET
admet-1465	133	20	concentration	concentration	NOUN
admet-1465	133	21	gradient	gradient	NOUN
admet-1465	133	22	is	be	AUX
admet-1465	133	23	consequently	consequently	ADV
admet-1465	133	24	higher	high	ADJ
admet-1465	133	25	,	,	PUNCT
admet-1465	133	26	which	which	PRON
admet-1465	133	27	results	result	VERB
admet-1465	133	28	in	in	ADP
admet-1465	133	29	faster	fast	ADJ
admet-1465	133	30	dex	dex	NOUN
admet-1465	133	31	release	release	NOUN
admet-1465	133	32	from	from	ADP
admet-1465	133	33	the	the	DET
admet-1465	133	34	isopropanol	isopropanol	NOUN
admet-1465	133	35	-	-	PUNCT
admet-1465	133	36	containing	contain	VERB
admet-1465	133	37	formulation	formulation	NOUN
admet-1465	133	38	in	in	ADP
admet-1465	133	39	the	the	DET
admet-1465	133	40	case	case	NOUN
admet-1465	133	41	where	where	SCONJ
admet-1465	133	42	rc	rc	PROPN
admet-1465	133	43	membranes	membrane	NOUN
admet-1465	133	44	are	be	AUX
admet-1465	133	45	a	a	DET
admet-1465	133	46	rate	rate	NOUN
admet-1465	133	47	-	-	PUNCT
admet-1465	133	48	limiting	limit	VERB
admet-1465	133	49	factor	factor	NOUN
admet-1465	133	50	.	.	PUNCT
admet-1465	134	1	admet	admet	PROPN
admet-1465	134	2	&	&	CCONJ
admet-1465	134	3	dmpk	dmpk	PROPN
admet-1465	134	4	10(4	10(4	NUM
admet-1465	134	5	)	)	PUNCT
admet-1465	134	6	(	(	PUNCT
admet-1465	134	7	2022	2022	NUM
admet-1465	134	8	)	)	PUNCT
admet-1465	134	9	315	315	NUM
admet-1465	134	10	-	-	SYM
admet-1465	134	11	329	329	NUM
admet-1465	134	12	dexamethasone	dexamethasone	NOUN
admet-1465	134	13	release	release	NOUN
admet-1465	134	14	from	from	ADP
admet-1465	134	15	the	the	DET
admet-1465	134	16	oil	oil	NOUN
admet-1465	134	17	solutions	solution	NOUN
admet-1465	134	18	doi	doi	NOUN
admet-1465	134	19	:	:	PUNCT
admet-1465	134	20	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	134	21	321	321	NUM
admet-1465	134	22	figure	figure	NOUN
admet-1465	134	23	2	2	NUM
admet-1465	134	24	.	.	PUNCT
admet-1465	134	25	ivr	ivr	NOUN
admet-1465	134	26	profiles	profile	NOUN
admet-1465	134	27	using	use	VERB
admet-1465	134	28	two	two	NUM
admet-1465	134	29	different	different	ADJ
admet-1465	134	30	types	type	NOUN
admet-1465	134	31	of	of	ADP
admet-1465	134	32	dialysis	dialysis	NOUN
admet-1465	134	33	membranes	membrane	NOUN
admet-1465	134	34	(	(	PUNCT
admet-1465	134	35	ce	ce	PROPN
admet-1465	134	36	with	with	ADP
admet-1465	134	37	mwco	mwco	NOUN
admet-1465	134	38	300	300	NUM
admet-1465	134	39	kda	kda	NOUN
admet-1465	134	40	(	(	PUNCT
admet-1465	134	41	solid	solid	ADJ
admet-1465	134	42	line	line	NOUN
admet-1465	134	43	)	)	PUNCT
admet-1465	134	44	and	and	CCONJ
admet-1465	134	45	rc	rc	PROPN
admet-1465	134	46	with	with	ADP
admet-1465	134	47	mwco	mwco	PROPN
admet-1465	134	48	50	50	NUM
admet-1465	134	49	kda	kda	NOUN
admet-1465	134	50	(	(	PUNCT
admet-1465	134	51	dashed	dash	VERB
admet-1465	134	52	line	line	NOUN
admet-1465	134	53	)	)	PUNCT
admet-1465	134	54	)	)	PUNCT
admet-1465	134	55	for	for	ADP
admet-1465	134	56	isopropanol	isopropanol	NOUN
admet-1465	134	57	(	(	PUNCT
admet-1465	134	58	orange	orange	ADJ
admet-1465	134	59	)	)	PUNCT
admet-1465	134	60	and	and	CCONJ
admet-1465	134	61	capryol	capryol	ADV
admet-1465	134	62	®	®	NOUN
admet-1465	134	63	90	90	NUM
admet-1465	134	64	(	(	PUNCT
admet-1465	134	65	blue	blue	ADJ
admet-1465	134	66	)	)	PUNCT
admet-1465	134	67	test	test	NOUN
admet-1465	134	68	solutions	solution	NOUN
admet-1465	134	69	.	.	PUNCT
admet-1465	135	1	other	other	ADJ
admet-1465	135	2	test	test	NOUN
admet-1465	135	3	parameters	parameter	NOUN
admet-1465	135	4	:	:	PUNCT
admet-1465	135	5	75	75	NUM
admet-1465	135	6	rpm	rpm	NOUN
admet-1465	135	7	,	,	PUNCT
admet-1465	135	8	37	37	NUM
admet-1465	135	9	°	°	NOUN
admet-1465	135	10	c	c	NOUN
admet-1465	135	11	,	,	PUNCT
admet-1465	135	12	500	500	NUM
admet-1465	135	13	ml	ml	NOUN
admet-1465	135	14	of	of	ADP
admet-1465	135	15	phosphate	phosphate	ADJ
admet-1465	135	16	buffer	buffer	NOUN
admet-1465	135	17	ph	ph	VERB
admet-1465	135	18	7.4	7.4	NUM
admet-1465	135	19	release	release	NOUN
admet-1465	135	20	medium	medium	NOUN
admet-1465	135	21	.	.	PUNCT
admet-1465	136	1	error	error	NOUN
admet-1465	136	2	bars	bar	NOUN
admet-1465	136	3	represent	represent	VERB
admet-1465	136	4	standard	standard	ADJ
admet-1465	136	5	deviation	deviation	NOUN
admet-1465	136	6	,	,	PUNCT
admet-1465	136	7	n=3	n=3	NOUN
admet-1465	136	8	.	.	PUNCT
admet-1465	137	1	temperature	temperature	VERB
admet-1465	137	2	the	the	DET
admet-1465	137	3	sensitivity	sensitivity	NOUN
admet-1465	137	4	of	of	ADP
admet-1465	137	5	the	the	DET
admet-1465	137	6	method	method	NOUN
admet-1465	137	7	to	to	ADP
admet-1465	137	8	temperature	temperature	NOUN
admet-1465	137	9	conditions	condition	NOUN
admet-1465	137	10	was	be	AUX
admet-1465	137	11	examined	examine	VERB
admet-1465	137	12	using	use	VERB
admet-1465	137	13	both	both	DET
admet-1465	137	14	test	test	NOUN
admet-1465	137	15	solutions	solution	NOUN
admet-1465	137	16	at	at	ADP
admet-1465	137	17	25	25	NUM
admet-1465	137	18	°	°	NOUN
admet-1465	137	19	c	c	NOUN
admet-1465	137	20	and	and	CCONJ
admet-1465	138	1	37	37	NUM
admet-1465	138	2	°	°	NOUN
admet-1465	138	3	c	c	NOUN
admet-1465	138	4	.	.	PUNCT
admet-1465	139	1	following	follow	VERB
admet-1465	139	2	basic	basic	ADJ
admet-1465	139	3	physical	physical	ADJ
admet-1465	139	4	principles	principle	NOUN
admet-1465	139	5	,	,	PUNCT
admet-1465	139	6	a	a	DET
admet-1465	139	7	slower	slow	ADJ
admet-1465	139	8	release	release	NOUN
admet-1465	139	9	is	be	AUX
admet-1465	139	10	expected	expect	VERB
admet-1465	139	11	at	at	ADP
admet-1465	139	12	a	a	DET
admet-1465	139	13	lower	low	ADJ
admet-1465	139	14	temperature	temperature	NOUN
admet-1465	139	15	due	due	ADP
admet-1465	139	16	to	to	ADP
admet-1465	139	17	slower	slow	ADJ
admet-1465	139	18	rates	rate	NOUN
admet-1465	139	19	of	of	ADP
admet-1465	139	20	every	every	DET
admet-1465	139	21	process	process	NOUN
admet-1465	139	22	involved	involve	VERB
admet-1465	139	23	in	in	ADP
admet-1465	139	24	dex	dex	NOUN
admet-1465	139	25	release	release	NOUN
admet-1465	139	26	into	into	ADP
admet-1465	139	27	the	the	DET
admet-1465	139	28	medium	medium	NOUN
admet-1465	139	29	.	.	PUNCT
admet-1465	140	1	ivr	ivr	PROPN
admet-1465	140	2	profiles	profile	NOUN
admet-1465	140	3	presented	present	VERB
admet-1465	140	4	in	in	ADP
admet-1465	140	5	figure	figure	NOUN
admet-1465	140	6	3	3	NUM
admet-1465	140	7	confirm	confirm	VERB
admet-1465	140	8	this	this	DET
admet-1465	140	9	hypothesis	hypothesis	NOUN
admet-1465	140	10	and	and	CCONJ
admet-1465	140	11	show	show	VERB
admet-1465	140	12	that	that	SCONJ
admet-1465	140	13	the	the	DET
admet-1465	140	14	method	method	NOUN
admet-1465	140	15	is	be	AUX
admet-1465	140	16	sensitive	sensitive	ADJ
admet-1465	140	17	to	to	ADP
admet-1465	140	18	temperature	temperature	NOUN
admet-1465	140	19	.	.	PUNCT
admet-1465	141	1	controlled	control	VERB
admet-1465	141	2	temperature	temperature	NOUN
admet-1465	141	3	during	during	ADP
admet-1465	141	4	the	the	DET
admet-1465	141	5	test	test	NOUN
admet-1465	141	6	is	be	AUX
admet-1465	141	7	a	a	DET
admet-1465	141	8	critical	critical	ADJ
admet-1465	141	9	parameter	parameter	NOUN
admet-1465	141	10	for	for	ADP
admet-1465	141	11	this	this	DET
admet-1465	141	12	method	method	NOUN
admet-1465	141	13	.	.	PUNCT
admet-1465	142	1	figure	figure	NOUN
admet-1465	142	2	3	3	NUM
admet-1465	142	3	.	.	PUNCT
admet-1465	142	4	ivr	ivr	PROPN
admet-1465	142	5	profiles	profile	NOUN
admet-1465	142	6	at	at	ADP
admet-1465	142	7	two	two	NUM
admet-1465	142	8	different	different	ADJ
admet-1465	142	9	temperatures	temperature	NOUN
admet-1465	142	10	(	(	PUNCT
admet-1465	142	11	25	25	NUM
admet-1465	142	12	°	°	NOUN
admet-1465	142	13	c	c	X
admet-1465	142	14	(	(	PUNCT
admet-1465	142	15	dashed	dash	VERB
admet-1465	142	16	line	line	NOUN
admet-1465	142	17	)	)	PUNCT
admet-1465	142	18	and	and	CCONJ
admet-1465	142	19	37	37	NUM
admet-1465	142	20	°	°	NOUN
admet-1465	142	21	c	c	X
admet-1465	142	22	(	(	PUNCT
admet-1465	142	23	solid	solid	ADJ
admet-1465	142	24	line	line	NOUN
admet-1465	142	25	)	)	PUNCT
admet-1465	142	26	)	)	PUNCT
admet-1465	142	27	for	for	ADP
admet-1465	142	28	isopropanol	isopropanol	NOUN
admet-1465	142	29	(	(	PUNCT
admet-1465	142	30	orange	orange	ADJ
admet-1465	142	31	)	)	PUNCT
admet-1465	142	32	and	and	CCONJ
admet-1465	142	33	capryol	capryol	ADV
admet-1465	142	34	®	®	NOUN
admet-1465	142	35	90	90	NUM
admet-1465	142	36	(	(	PUNCT
admet-1465	142	37	blue	blue	ADJ
admet-1465	142	38	)	)	PUNCT
admet-1465	142	39	test	test	NOUN
admet-1465	142	40	solutions	solution	NOUN
admet-1465	142	41	.	.	PUNCT
admet-1465	143	1	other	other	ADJ
admet-1465	143	2	test	test	NOUN
admet-1465	143	3	parameters	parameter	NOUN
admet-1465	143	4	:	:	PUNCT
admet-1465	143	5	ce	ce	PROPN
admet-1465	143	6	membranes	membrane	NOUN
admet-1465	143	7	,	,	PUNCT
admet-1465	143	8	75	75	NUM
admet-1465	143	9	rpm	rpm	NOUN
admet-1465	143	10	,	,	PUNCT
admet-1465	143	11	500	500	NUM
admet-1465	143	12	ml	ml	NOUN
admet-1465	143	13	of	of	ADP
admet-1465	143	14	phosphate	phosphate	ADJ
admet-1465	143	15	buffer	buffer	NOUN
admet-1465	143	16	ph	ph	VERB
admet-1465	143	17	7.4	7.4	NUM
admet-1465	143	18	release	release	NOUN
admet-1465	143	19	medium	medium	NOUN
admet-1465	143	20	.	.	PUNCT
admet-1465	144	1	error	error	NOUN
admet-1465	144	2	bars	bar	NOUN
admet-1465	144	3	represent	represent	VERB
admet-1465	144	4	standard	standard	ADJ
admet-1465	144	5	deviation	deviation	NOUN
admet-1465	144	6	,	,	PUNCT
admet-1465	144	7	n=3	n=3	NOUN
admet-1465	144	8	.	.	NOUN
admet-1465	145	1	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	145	2	filip	filip	PROPN
admet-1465	145	3	kozlina	kozlina	PROPN
admet-1465	145	4	et	et	PROPN
admet-1465	145	5	al	al	PROPN
admet-1465	145	6	.	.	PROPN
admet-1465	145	7	admet	admet	PROPN
admet-1465	145	8	&	&	CCONJ
admet-1465	145	9	dmpk	dmpk	PROPN
admet-1465	145	10	10(4	10(4	NUM
admet-1465	145	11	)	)	PUNCT
admet-1465	145	12	(	(	PUNCT
admet-1465	145	13	2022	2022	NUM
admet-1465	145	14	)	)	PUNCT
admet-1465	145	15	315	315	NUM
admet-1465	145	16	-	-	SYM
admet-1465	145	17	329	329	NUM
admet-1465	145	18	322	322	NUM
admet-1465	145	19	release	release	NOUN
admet-1465	145	20	medium	medium	ADJ
admet-1465	145	21	stirring	stirring	NOUN
admet-1465	145	22	rate	rate	NOUN
admet-1465	145	23	the	the	DET
admet-1465	145	24	stirring	stir	VERB
admet-1465	145	25	rate	rate	NOUN
admet-1465	145	26	is	be	AUX
admet-1465	145	27	considered	consider	VERB
admet-1465	145	28	an	an	DET
admet-1465	145	29	essential	essential	ADJ
admet-1465	145	30	parameter	parameter	NOUN
admet-1465	145	31	for	for	ADP
admet-1465	145	32	ivr	ivr	NOUN
admet-1465	145	33	methods	method	NOUN
admet-1465	145	34	and	and	CCONJ
admet-1465	145	35	must	must	AUX
admet-1465	145	36	be	be	AUX
admet-1465	145	37	carefully	carefully	ADV
admet-1465	145	38	chosen	choose	VERB
admet-1465	145	39	and	and	CCONJ
admet-1465	145	40	evaluated	evaluate	VERB
admet-1465	145	41	.	.	PUNCT
admet-1465	146	1	unexpected	unexpected	ADJ
admet-1465	146	2	results	result	NOUN
admet-1465	146	3	,	,	PUNCT
admet-1465	146	4	which	which	PRON
admet-1465	146	5	might	might	AUX
admet-1465	146	6	arise	arise	VERB
admet-1465	146	7	using	use	VERB
admet-1465	146	8	an	an	DET
admet-1465	146	9	insufficient	insufficient	ADJ
admet-1465	146	10	stirring	stirring	NOUN
admet-1465	146	11	rate	rate	NOUN
admet-1465	146	12	,	,	PUNCT
admet-1465	146	13	include	include	VERB
admet-1465	146	14	thickening	thickening	NOUN
admet-1465	146	15	of	of	ADP
admet-1465	146	16	the	the	DET
admet-1465	146	17	diffusion	diffusion	NOUN
admet-1465	146	18	layer	layer	NOUN
admet-1465	146	19	,	,	PUNCT
admet-1465	146	20	leading	lead	VERB
admet-1465	146	21	to	to	ADP
admet-1465	146	22	a	a	DET
admet-1465	146	23	lowered	lower	VERB
admet-1465	146	24	concentration	concentration	NOUN
admet-1465	146	25	gradient	gradient	NOUN
admet-1465	146	26	and	and	CCONJ
admet-1465	146	27	diffusion	diffusion	NOUN
admet-1465	146	28	potential	potential	NOUN
admet-1465	146	29	and	and	CCONJ
admet-1465	146	30	finally	finally	ADV
admet-1465	146	31	resulting	result	VERB
admet-1465	146	32	in	in	ADP
admet-1465	146	33	a	a	DET
admet-1465	146	34	lower	low	ADJ
admet-1465	146	35	release	release	NOUN
admet-1465	146	36	rate	rate	NOUN
admet-1465	146	37	.	.	PUNCT
admet-1465	147	1	on	on	ADP
admet-1465	147	2	the	the	DET
admet-1465	147	3	other	other	ADJ
admet-1465	147	4	hand	hand	NOUN
admet-1465	147	5	,	,	PUNCT
admet-1465	147	6	if	if	SCONJ
admet-1465	147	7	the	the	DET
admet-1465	147	8	stirring	stirring	NOUN
admet-1465	147	9	rate	rate	NOUN
admet-1465	147	10	is	be	AUX
admet-1465	147	11	too	too	ADV
admet-1465	147	12	high	high	ADJ
admet-1465	147	13	,	,	PUNCT
admet-1465	147	14	the	the	DET
admet-1465	147	15	method	method	NOUN
admet-1465	147	16	loses	lose	VERB
admet-1465	147	17	its	its	PRON
admet-1465	147	18	discriminatory	discriminatory	ADJ
admet-1465	147	19	power	power	NOUN
admet-1465	147	20	.	.	PUNCT
admet-1465	148	1	using	use	VERB
admet-1465	148	2	the	the	DET
admet-1465	148	3	usp	usp	PROPN
admet-1465	148	4	ii	ii	PROPN
admet-1465	148	5	apparatus	apparatus	NOUN
admet-1465	148	6	,	,	PUNCT
admet-1465	148	7	the	the	DET
admet-1465	148	8	fda	fda	PROPN
admet-1465	148	9	recommends	recommend	VERB
admet-1465	148	10	a	a	DET
admet-1465	148	11	stirring	stir	VERB
admet-1465	148	12	rate	rate	NOUN
admet-1465	148	13	of	of	ADP
admet-1465	148	14	50	50	NUM
admet-1465	148	15	to	to	PART
admet-1465	148	16	75	75	NUM
admet-1465	148	17	rpm	rpm	NOUN
admet-1465	148	18	[	[	X
admet-1465	148	19	1	1	NUM
admet-1465	148	20	]	]	PUNCT
admet-1465	148	21	.	.	PUNCT
admet-1465	149	1	therefore	therefore	ADV
admet-1465	149	2	,	,	PUNCT
admet-1465	149	3	the	the	DET
admet-1465	149	4	release	release	NOUN
admet-1465	149	5	was	be	AUX
admet-1465	149	6	tested	test	VERB
admet-1465	149	7	using	use	VERB
admet-1465	149	8	these	these	DET
admet-1465	149	9	two	two	NUM
admet-1465	149	10	stirring	stir	VERB
admet-1465	149	11	rates	rate	NOUN
admet-1465	149	12	.	.	PUNCT
admet-1465	150	1	the	the	DET
admet-1465	150	2	method	method	NOUN
admet-1465	150	3	is	be	AUX
admet-1465	150	4	not	not	PART
admet-1465	150	5	very	very	ADV
admet-1465	150	6	sensitive	sensitive	ADJ
admet-1465	150	7	to	to	ADP
admet-1465	150	8	different	different	ADJ
admet-1465	150	9	stirring	stirring	NOUN
admet-1465	150	10	rates	rate	NOUN
admet-1465	150	11	.	.	PUNCT
admet-1465	151	1	however	however	ADV
admet-1465	151	2	,	,	PUNCT
admet-1465	151	3	slightly	slightly	ADV
admet-1465	151	4	higher	high	ADJ
admet-1465	151	5	drug	drug	NOUN
admet-1465	151	6	release	release	NOUN
admet-1465	151	7	rates	rate	NOUN
admet-1465	151	8	were	be	AUX
admet-1465	151	9	observed	observe	VERB
admet-1465	151	10	when	when	SCONJ
admet-1465	151	11	higher	high	ADJ
admet-1465	151	12	stirring	stirring	NOUN
admet-1465	151	13	rates	rate	NOUN
admet-1465	151	14	were	be	AUX
admet-1465	151	15	applied	apply	VERB
admet-1465	151	16	(	(	PUNCT
admet-1465	151	17	figure	figure	NOUN
admet-1465	151	18	4	4	NUM
admet-1465	151	19	)	)	PUNCT
admet-1465	151	20	.	.	PUNCT
admet-1465	152	1	figure	figure	VERB
admet-1465	152	2	4	4	NUM
admet-1465	152	3	.	.	PUNCT
admet-1465	152	4	ivr	ivr	PROPN
admet-1465	152	5	profiles	profile	NOUN
admet-1465	152	6	at	at	ADP
admet-1465	152	7	two	two	NUM
admet-1465	152	8	different	different	ADJ
admet-1465	152	9	stirring	stirring	NOUN
admet-1465	152	10	rates	rate	NOUN
admet-1465	152	11	(	(	PUNCT
admet-1465	152	12	50	50	NUM
admet-1465	152	13	rpm	rpm	NOUN
admet-1465	152	14	(	(	PUNCT
admet-1465	152	15	solid	solid	ADJ
admet-1465	152	16	line	line	NOUN
admet-1465	152	17	)	)	PUNCT
admet-1465	152	18	and	and	CCONJ
admet-1465	152	19	75	75	NUM
admet-1465	152	20	rpm	rpm	NOUN
admet-1465	152	21	(	(	PUNCT
admet-1465	152	22	dashed	dash	VERB
admet-1465	152	23	line	line	NOUN
admet-1465	152	24	)	)	PUNCT
admet-1465	152	25	)	)	PUNCT
admet-1465	152	26	for	for	ADP
admet-1465	152	27	isopropanol	isopropanol	NOUN
admet-1465	152	28	(	(	PUNCT
admet-1465	152	29	orange	orange	ADJ
admet-1465	152	30	)	)	PUNCT
admet-1465	152	31	and	and	CCONJ
admet-1465	152	32	capryol	capryol	ADV
admet-1465	152	33	®	®	NOUN
admet-1465	152	34	90	90	NUM
admet-1465	152	35	(	(	PUNCT
admet-1465	152	36	blue	blue	ADJ
admet-1465	152	37	)	)	PUNCT
admet-1465	152	38	test	test	NOUN
admet-1465	152	39	solutions	solution	NOUN
admet-1465	152	40	.	.	PUNCT
admet-1465	153	1	other	other	ADJ
admet-1465	153	2	test	test	NOUN
admet-1465	153	3	parameters	parameter	NOUN
admet-1465	153	4	:	:	PUNCT
admet-1465	153	5	rc	rc	PROPN
admet-1465	153	6	membranes	membrane	NOUN
admet-1465	153	7	,	,	PUNCT
admet-1465	153	8	37	37	NUM
admet-1465	153	9	°	°	NOUN
admet-1465	153	10	c	c	NOUN
admet-1465	153	11	,	,	PUNCT
admet-1465	153	12	500	500	NUM
admet-1465	153	13	ml	ml	NOUN
admet-1465	153	14	of	of	ADP
admet-1465	153	15	phosphate	phosphate	ADJ
admet-1465	153	16	buffer	buffer	NOUN
admet-1465	153	17	ph	ph	VERB
admet-1465	153	18	7.4	7.4	NUM
admet-1465	153	19	release	release	NOUN
admet-1465	153	20	medium	medium	NOUN
admet-1465	153	21	.	.	PUNCT
admet-1465	154	1	error	error	NOUN
admet-1465	154	2	bars	bar	NOUN
admet-1465	154	3	represent	represent	VERB
admet-1465	154	4	standard	standard	ADJ
admet-1465	154	5	deviation	deviation	NOUN
admet-1465	154	6	,	,	PUNCT
admet-1465	154	7	n=3	n=3	NOUN
admet-1465	154	8	.	.	PUNCT
admet-1465	155	1	composition	composition	NOUN
admet-1465	155	2	of	of	ADP
admet-1465	155	3	the	the	DET
admet-1465	155	4	release	release	NOUN
admet-1465	155	5	medium	medium	NOUN
admet-1465	155	6	aiming	aim	VERB
admet-1465	155	7	to	to	PART
admet-1465	155	8	reduce	reduce	VERB
admet-1465	155	9	the	the	DET
admet-1465	155	10	method	method	NOUN
admet-1465	155	11	duration	duration	NOUN
admet-1465	155	12	,	,	PUNCT
admet-1465	155	13	dex	dex	NOUN
admet-1465	155	14	release	release	NOUN
admet-1465	155	15	from	from	ADP
admet-1465	155	16	test	test	NOUN
admet-1465	155	17	solutions	solution	NOUN
admet-1465	155	18	was	be	AUX
admet-1465	155	19	analysed	analyse	VERB
admet-1465	155	20	using	use	VERB
admet-1465	155	21	a	a	DET
admet-1465	155	22	release	release	NOUN
admet-1465	155	23	medium	medium	NOUN
admet-1465	155	24	containing	contain	VERB
admet-1465	155	25	10	10	NUM
admet-1465	155	26	%	%	NOUN
admet-1465	155	27	(	(	PUNCT
admet-1465	155	28	v	v	NOUN
admet-1465	155	29	/	/	SYM
admet-1465	155	30	v	v	NOUN
admet-1465	155	31	)	)	PUNCT
admet-1465	155	32	ethanol	ethanol	NOUN
admet-1465	155	33	in	in	ADP
admet-1465	155	34	phosphate	phosphate	ADJ
admet-1465	155	35	buffer	buffer	NOUN
admet-1465	155	36	ph	ph	VERB
admet-1465	155	37	7.4	7.4	NUM
admet-1465	155	38	.	.	PUNCT
admet-1465	156	1	sink	sink	NOUN
admet-1465	156	2	conditions	condition	NOUN
admet-1465	156	3	were	be	AUX
admet-1465	156	4	ensured	ensure	VERB
admet-1465	156	5	during	during	ADP
admet-1465	156	6	these	these	DET
admet-1465	156	7	analyses	analysis	NOUN
admet-1465	156	8	as	as	ADV
admet-1465	156	9	well	well	ADV
admet-1465	156	10	.	.	PUNCT
admet-1465	157	1	the	the	DET
admet-1465	157	2	solubility	solubility	NOUN
admet-1465	157	3	of	of	ADP
admet-1465	157	4	dex	dex	NOUN
admet-1465	157	5	in	in	ADP
admet-1465	157	6	phosphate	phosphate	ADJ
admet-1465	157	7	buffer	buffer	NOUN
admet-1465	157	8	ph	ph	VERB
admet-1465	157	9	7.4	7.4	NUM
admet-1465	157	10	with	with	ADP
admet-1465	157	11	10	10	NUM
admet-1465	157	12	%	%	NOUN
admet-1465	157	13	(	(	PUNCT
admet-1465	157	14	v	v	NOUN
admet-1465	157	15	/	/	SYM
admet-1465	157	16	v	v	NOUN
admet-1465	157	17	)	)	PUNCT
admet-1465	157	18	ethanol	ethanol	NOUN
admet-1465	157	19	is	be	AUX
admet-1465	157	20	0.17	0.17	NUM
admet-1465	157	21	mg	mg	PROPN
admet-1465	157	22	/	/	SYM
admet-1465	157	23	ml	ml	X
admet-1465	158	1	[	[	X
admet-1465	158	2	21	21	NUM
admet-1465	158	3	]	]	PUNCT
admet-1465	158	4	.	.	PUNCT
admet-1465	159	1	according	accord	VERB
admet-1465	159	2	to	to	ADP
admet-1465	159	3	the	the	DET
admet-1465	159	4	usp	usp	NOUN
admet-1465	159	5	criteria	criterion	NOUN
admet-1465	159	6	,	,	PUNCT
admet-1465	159	7	the	the	DET
admet-1465	159	8	volume	volume	NOUN
admet-1465	159	9	of	of	ADP
admet-1465	159	10	the	the	DET
admet-1465	159	11	release	release	NOUN
admet-1465	159	12	medium	medium	NOUN
admet-1465	159	13	to	to	PART
admet-1465	159	14	ensure	ensure	VERB
admet-1465	159	15	sink	sink	NOUN
admet-1465	159	16	conditions	condition	NOUN
admet-1465	159	17	for	for	ADP
admet-1465	159	18	dex	dex	NOUN
admet-1465	159	19	should	should	AUX
admet-1465	159	20	be	be	AUX
admet-1465	159	21	238	238	NUM
admet-1465	159	22	ml	ml	NOUN
admet-1465	159	23	,	,	PUNCT
admet-1465	159	24	while	while	SCONJ
admet-1465	159	25	to	to	PART
admet-1465	159	26	ph	ph	PROPN
admet-1465	159	27	.	.	PROPN
admet-1465	159	28	eur	eur	PROPN
admet-1465	159	29	.	.	PUNCT
admet-1465	159	30	criteria	criterion	NOUN
admet-1465	159	31	in	in	ADP
admet-1465	159	32	the	the	DET
admet-1465	159	33	range	range	NOUN
admet-1465	159	34	from	from	ADP
admet-1465	159	35	238	238	NUM
admet-1465	159	36	ml	ml	NOUN
admet-1465	159	37	to	to	ADP
admet-1465	159	38	473	473	NUM
admet-1465	159	39	ml	ml	NOUN
admet-1465	159	40	.	.	PUNCT
admet-1465	160	1	considering	consider	VERB
admet-1465	160	2	that	that	SCONJ
admet-1465	160	3	dex	dex	NOUN
admet-1465	160	4	is	be	AUX
admet-1465	160	5	more	more	ADV
admet-1465	160	6	soluble	soluble	ADJ
admet-1465	160	7	in	in	ADP
admet-1465	160	8	ethanol	ethanol	NOUN
admet-1465	160	9	than	than	ADP
admet-1465	160	10	in	in	ADP
admet-1465	160	11	water	water	NOUN
admet-1465	160	12	solutions	solution	NOUN
admet-1465	160	13	,	,	PUNCT
admet-1465	160	14	it	it	PRON
admet-1465	160	15	was	be	AUX
admet-1465	160	16	presumed	presume	VERB
admet-1465	160	17	that	that	SCONJ
admet-1465	160	18	the	the	DET
admet-1465	160	19	release	release	NOUN
admet-1465	160	20	rate	rate	NOUN
admet-1465	160	21	is	be	AUX
admet-1465	160	22	going	go	VERB
admet-1465	160	23	to	to	PART
admet-1465	160	24	be	be	AUX
admet-1465	160	25	higher	high	ADJ
admet-1465	160	26	in	in	ADP
admet-1465	160	27	the	the	DET
admet-1465	160	28	medium	medium	NOUN
admet-1465	160	29	with	with	ADP
admet-1465	160	30	the	the	DET
admet-1465	160	31	addition	addition	NOUN
admet-1465	160	32	of	of	ADP
admet-1465	160	33	ethanol	ethanol	NOUN
admet-1465	160	34	than	than	ADP
admet-1465	160	35	in	in	ADP
admet-1465	160	36	the	the	DET
admet-1465	160	37	phosphate	phosphate	ADJ
admet-1465	160	38	buffer	buffer	NOUN
admet-1465	160	39	alone	alone	ADV
admet-1465	160	40	.	.	PUNCT
admet-1465	161	1	however	however	ADV
admet-1465	161	2	,	,	PUNCT
admet-1465	161	3	the	the	DET
admet-1465	161	4	results	result	NOUN
admet-1465	161	5	were	be	AUX
admet-1465	161	6	entirely	entirely	ADV
admet-1465	161	7	different	different	ADJ
admet-1465	161	8	(	(	PUNCT
admet-1465	161	9	figure	figure	NOUN
admet-1465	161	10	5	5	NUM
admet-1465	161	11	)	)	PUNCT
admet-1465	161	12	.	.	PUNCT
admet-1465	162	1	the	the	DET
admet-1465	162	2	overall	overall	ADJ
admet-1465	162	3	percentage	percentage	NOUN
admet-1465	162	4	of	of	ADP
admet-1465	162	5	dex	dex	NOUN
admet-1465	162	6	released	release	VERB
admet-1465	162	7	after	after	ADP
admet-1465	162	8	24	24	NUM
admet-1465	162	9	hours	hour	NOUN
admet-1465	162	10	was	be	AUX
admet-1465	162	11	lower	low	ADJ
admet-1465	162	12	for	for	ADP
admet-1465	162	13	both	both	DET
admet-1465	162	14	test	test	NOUN
admet-1465	162	15	solutions	solution	NOUN
admet-1465	162	16	using	use	VERB
admet-1465	162	17	the	the	DET
admet-1465	162	18	release	release	NOUN
admet-1465	162	19	medium	medium	NOUN
admet-1465	162	20	with	with	ADP
admet-1465	162	21	10	10	NUM
admet-1465	162	22	%	%	NOUN
admet-1465	162	23	ethanol	ethanol	NOUN
admet-1465	162	24	and	and	CCONJ
admet-1465	162	25	even	even	ADV
admet-1465	162	26	throughout	throughout	ADP
admet-1465	162	27	the	the	DET
admet-1465	162	28	entire	entire	ADJ
admet-1465	162	29	test	test	NOUN
admet-1465	162	30	for	for	ADP
admet-1465	162	31	the	the	DET
admet-1465	162	32	isopropanol	isopropanol	NOUN
admet-1465	162	33	test	test	NOUN
admet-1465	162	34	solution	solution	NOUN
admet-1465	162	35	.	.	PUNCT
admet-1465	163	1	this	this	PRON
admet-1465	163	2	is	be	AUX
admet-1465	163	3	probably	probably	ADV
admet-1465	163	4	due	due	ADJ
admet-1465	163	5	to	to	ADP
admet-1465	163	6	the	the	DET
admet-1465	163	7	fact	fact	NOUN
admet-1465	163	8	that	that	SCONJ
admet-1465	163	9	ethanol	ethanol	NOUN
admet-1465	163	10	itself	itself	PRON
admet-1465	163	11	can	can	AUX
admet-1465	163	12	diffuse	diffuse	VERB
admet-1465	163	13	from	from	ADP
admet-1465	163	14	the	the	DET
admet-1465	163	15	release	release	NOUN
admet-1465	163	16	medium	medium	NOUN
admet-1465	163	17	into	into	ADP
admet-1465	163	18	the	the	DET
admet-1465	163	19	test	test	NOUN
admet-1465	163	20	solution	solution	NOUN
admet-1465	163	21	through	through	ADP
admet-1465	163	22	the	the	DET
admet-1465	163	23	dialysis	dialysis	NOUN
admet-1465	163	24	membrane	membrane	NOUN
admet-1465	163	25	pores	pore	NOUN
admet-1465	163	26	,	,	PUNCT
admet-1465	163	27	thus	thus	ADV
admet-1465	163	28	increasing	increase	VERB
admet-1465	163	29	the	the	DET
admet-1465	163	30	solubility	solubility	NOUN
admet-1465	163	31	of	of	ADP
admet-1465	163	32	both	both	DET
admet-1465	163	33	dex	dex	NOUN
admet-1465	163	34	and	and	CCONJ
admet-1465	163	35	cosolvent	cosolvent	ADJ
admet-1465	163	36	and	and	CCONJ
admet-1465	163	37	lowering	lower	VERB
admet-1465	163	38	dex	dex	NOUN
admet-1465	163	39	partitioning	partitioning	NOUN
admet-1465	163	40	into	into	ADP
admet-1465	163	41	the	the	DET
admet-1465	163	42	release	release	NOUN
admet-1465	163	43	medium	medium	NOUN
admet-1465	163	44	,	,	PUNCT
admet-1465	163	45	as	as	ADV
admet-1465	163	46	well	well	ADV
admet-1465	163	47	as	as	ADP
admet-1465	163	48	its	its	PRON
admet-1465	163	49	release	release	NOUN
admet-1465	163	50	rate	rate	NOUN
admet-1465	163	51	.	.	PUNCT
admet-1465	164	1	this	this	DET
admet-1465	164	2	effect	effect	NOUN
admet-1465	164	3	is	be	AUX
admet-1465	164	4	more	more	ADV
admet-1465	164	5	pronounced	pronounced	ADJ
admet-1465	164	6	with	with	ADP
admet-1465	164	7	the	the	DET
admet-1465	164	8	isopropanol	isopropanol	NOUN
admet-1465	164	9	compared	compare	VERB
admet-1465	164	10	to	to	ADP
admet-1465	164	11	the	the	DET
admet-1465	164	12	capryol	capryol	NOUN
admet-1465	164	13	®	®	NOUN
admet-1465	164	14	90	90	NUM
admet-1465	164	15	test	test	NOUN
admet-1465	164	16	solution	solution	NOUN
admet-1465	164	17	,	,	PUNCT
admet-1465	164	18	presumably	presumably	ADV
admet-1465	164	19	due	due	ADP
admet-1465	164	20	to	to	ADP
admet-1465	164	21	its	its	PRON
admet-1465	164	22	alcoholic	alcoholic	ADJ
admet-1465	164	23	nature	nature	NOUN
admet-1465	164	24	.	.	PUNCT
admet-1465	165	1	admet	admet	PROPN
admet-1465	165	2	&	&	CCONJ
admet-1465	165	3	dmpk	dmpk	PROPN
admet-1465	165	4	10(4	10(4	NUM
admet-1465	165	5	)	)	PUNCT
admet-1465	165	6	(	(	PUNCT
admet-1465	165	7	2022	2022	NUM
admet-1465	165	8	)	)	PUNCT
admet-1465	165	9	315	315	NUM
admet-1465	165	10	-	-	SYM
admet-1465	165	11	329	329	NUM
admet-1465	165	12	dexamethasone	dexamethasone	NOUN
admet-1465	165	13	release	release	NOUN
admet-1465	165	14	from	from	ADP
admet-1465	165	15	the	the	DET
admet-1465	165	16	oil	oil	NOUN
admet-1465	165	17	solutions	solution	NOUN
admet-1465	165	18	doi	doi	NOUN
admet-1465	165	19	:	:	PUNCT
admet-1465	165	20	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	165	21	323	323	NUM
admet-1465	165	22	figure	figure	NOUN
admet-1465	165	23	5	5	NUM
admet-1465	165	24	.	.	PUNCT
admet-1465	166	1	ivr	ivr	NOUN
admet-1465	166	2	profiles	profile	NOUN
admet-1465	166	3	using	use	VERB
admet-1465	166	4	phosphate	phosphate	NOUN
admet-1465	166	5	buffer	buffer	NOUN
admet-1465	166	6	(	(	PUNCT
admet-1465	166	7	ph	ph	NOUN
admet-1465	166	8	7.4	7.4	NUM
admet-1465	166	9	)	)	PUNCT
admet-1465	166	10	medium	medium	NOUN
admet-1465	166	11	alone	alone	ADV
admet-1465	166	12	(	(	PUNCT
admet-1465	166	13	solid	solid	ADJ
admet-1465	166	14	line	line	NOUN
admet-1465	166	15	)	)	PUNCT
admet-1465	166	16	and	and	CCONJ
admet-1465	166	17	modified	modify	VERB
admet-1465	166	18	medium	medium	NOUN
admet-1465	166	19	with	with	ADP
admet-1465	166	20	10	10	NUM
admet-1465	166	21	%	%	NOUN
admet-1465	166	22	(	(	PUNCT
admet-1465	166	23	v	v	NOUN
admet-1465	166	24	/	/	SYM
admet-1465	166	25	v	v	NOUN
admet-1465	166	26	)	)	PUNCT
admet-1465	166	27	ethanol	ethanol	NOUN
admet-1465	166	28	(	(	PUNCT
admet-1465	166	29	dashed	dash	VERB
admet-1465	166	30	line	line	NOUN
admet-1465	166	31	)	)	PUNCT
admet-1465	166	32	for	for	ADP
admet-1465	166	33	isopropanol	isopropanol	NOUN
admet-1465	166	34	(	(	PUNCT
admet-1465	166	35	orange	orange	ADJ
admet-1465	166	36	)	)	PUNCT
admet-1465	166	37	and	and	CCONJ
admet-1465	166	38	capryol	capryol	ADV
admet-1465	166	39	®	®	NOUN
admet-1465	166	40	90	90	NUM
admet-1465	166	41	(	(	PUNCT
admet-1465	166	42	blue	blue	ADJ
admet-1465	166	43	)	)	PUNCT
admet-1465	166	44	test	test	NOUN
admet-1465	166	45	solutions	solution	NOUN
admet-1465	166	46	.	.	PUNCT
admet-1465	167	1	other	other	ADJ
admet-1465	167	2	test	test	NOUN
admet-1465	167	3	parameters	parameter	NOUN
admet-1465	167	4	:	:	PUNCT
admet-1465	167	5	rc	rc	PROPN
admet-1465	167	6	membranes	membrane	NOUN
admet-1465	167	7	,	,	PUNCT
admet-1465	167	8	37	37	NUM
admet-1465	167	9	°	°	NOUN
admet-1465	167	10	c	c	NOUN
admet-1465	167	11	,	,	PUNCT
admet-1465	167	12	75	75	NUM
admet-1465	167	13	rpm	rpm	NOUN
admet-1465	167	14	,	,	PUNCT
admet-1465	167	15	500	500	NUM
admet-1465	167	16	ml	ml	NOUN
admet-1465	167	17	of	of	ADP
admet-1465	167	18	release	release	NOUN
admet-1465	167	19	medium	medium	NOUN
admet-1465	167	20	.	.	PUNCT
admet-1465	168	1	error	error	NOUN
admet-1465	168	2	bars	bar	NOUN
admet-1465	168	3	represent	represent	VERB
admet-1465	168	4	standard	standard	ADJ
admet-1465	168	5	deviation	deviation	NOUN
admet-1465	168	6	,	,	PUNCT
admet-1465	168	7	n=3	n=3	NOUN
admet-1465	168	8	.	.	PUNCT
admet-1465	169	1	volume	volume	NOUN
admet-1465	169	2	of	of	ADP
admet-1465	169	3	test	test	NOUN
admet-1465	169	4	solution	solution	NOUN
admet-1465	169	5	development	development	NOUN
admet-1465	169	6	and	and	CCONJ
admet-1465	169	7	evaluation	evaluation	NOUN
admet-1465	169	8	of	of	ADP
admet-1465	169	9	ivr	ivr	PROPN
admet-1465	169	10	methods	method	NOUN
admet-1465	169	11	often	often	ADV
admet-1465	169	12	include	include	VERB
admet-1465	169	13	evaluation	evaluation	NOUN
admet-1465	169	14	of	of	ADP
admet-1465	169	15	the	the	DET
admet-1465	169	16	sample	sample	NOUN
admet-1465	169	17	volume	volume	NOUN
admet-1465	169	18	on	on	ADP
admet-1465	169	19	release	release	NOUN
admet-1465	169	20	,	,	PUNCT
admet-1465	169	21	defining	define	VERB
admet-1465	169	22	whether	whether	SCONJ
admet-1465	169	23	the	the	DET
admet-1465	169	24	method	method	NOUN
admet-1465	169	25	is	be	AUX
admet-1465	169	26	sensitive	sensitive	ADJ
admet-1465	169	27	to	to	ADP
admet-1465	169	28	this	this	DET
admet-1465	169	29	parameter	parameter	NOUN
admet-1465	169	30	.	.	PUNCT
admet-1465	170	1	for	for	ADP
admet-1465	170	2	this	this	DET
admet-1465	170	3	purpose	purpose	NOUN
admet-1465	170	4	,	,	PUNCT
admet-1465	170	5	a	a	DET
admet-1465	170	6	twice	twice	ADV
admet-1465	170	7	lower	low	ADJ
admet-1465	170	8	volume	volume	NOUN
admet-1465	170	9	of	of	ADP
admet-1465	170	10	the	the	DET
admet-1465	170	11	test	test	NOUN
admet-1465	170	12	solution	solution	NOUN
admet-1465	170	13	(	(	PUNCT
admet-1465	170	14	500	500	NUM
admet-1465	170	15	μl	μl	NOUN
admet-1465	170	16	)	)	PUNCT
admet-1465	170	17	when	when	SCONJ
admet-1465	170	18	compared	compare	VERB
admet-1465	170	19	to	to	ADP
admet-1465	170	20	other	other	ADJ
admet-1465	170	21	experiments	experiment	NOUN
admet-1465	170	22	was	be	AUX
admet-1465	170	23	also	also	ADV
admet-1465	170	24	analysed	analyse	VERB
admet-1465	170	25	.	.	PUNCT
admet-1465	171	1	when	when	SCONJ
admet-1465	171	2	using	use	VERB
admet-1465	171	3	a	a	DET
admet-1465	171	4	smaller	small	ADJ
admet-1465	171	5	sample	sample	NOUN
admet-1465	171	6	volume	volume	NOUN
admet-1465	171	7	of	of	ADP
admet-1465	171	8	test	test	NOUN
admet-1465	171	9	solutions	solution	NOUN
admet-1465	171	10	with	with	ADP
admet-1465	171	11	rc	rc	PROPN
admet-1465	171	12	membranes	membrane	NOUN
admet-1465	171	13	,	,	PUNCT
admet-1465	171	14	great	great	ADJ
admet-1465	171	15	similarity	similarity	NOUN
admet-1465	171	16	between	between	ADP
admet-1465	171	17	the	the	DET
admet-1465	171	18	ivr	ivr	PROPN
admet-1465	171	19	profiles	profile	NOUN
admet-1465	171	20	of	of	ADP
admet-1465	171	21	both	both	DET
admet-1465	171	22	tested	test	VERB
admet-1465	171	23	formulations	formulation	NOUN
admet-1465	171	24	was	be	AUX
admet-1465	171	25	observed	observe	VERB
admet-1465	171	26	(	(	PUNCT
admet-1465	171	27	figure	figure	NOUN
admet-1465	171	28	6	6	NUM
admet-1465	171	29	)	)	PUNCT
admet-1465	171	30	.	.	PUNCT
admet-1465	172	1	in	in	ADP
admet-1465	172	2	these	these	DET
admet-1465	172	3	conditions	condition	NOUN
admet-1465	172	4	,	,	PUNCT
admet-1465	172	5	rc	rc	PROPN
admet-1465	172	6	membranes	membrane	NOUN
admet-1465	172	7	are	be	AUX
admet-1465	172	8	no	no	ADV
admet-1465	172	9	longer	long	ADV
admet-1465	172	10	a	a	DET
admet-1465	172	11	rate	rate	NOUN
admet-1465	172	12	-	-	PUNCT
admet-1465	172	13	limiting	limit	VERB
admet-1465	172	14	factor	factor	NOUN
admet-1465	172	15	.	.	PUNCT
admet-1465	173	1	on	on	ADP
admet-1465	173	2	the	the	DET
admet-1465	173	3	other	other	ADJ
admet-1465	173	4	hand	hand	NOUN
admet-1465	173	5	,	,	PUNCT
admet-1465	173	6	ce	ce	PROPN
admet-1465	173	7	membranes	membrane	NOUN
admet-1465	173	8	with	with	ADP
admet-1465	173	9	larger	large	ADJ
admet-1465	173	10	pore	pore	ADJ
admet-1465	173	11	sizes	size	NOUN
admet-1465	173	12	are	be	AUX
admet-1465	173	13	not	not	PART
admet-1465	173	14	a	a	DET
admet-1465	173	15	rate	rate	NOUN
admet-1465	173	16	-	-	PUNCT
admet-1465	173	17	limiting	limit	VERB
admet-1465	173	18	factor	factor	NOUN
admet-1465	173	19	even	even	ADV
admet-1465	173	20	when	when	SCONJ
admet-1465	173	21	1	1	NUM
admet-1465	173	22	ml	ml	NOUN
admet-1465	173	23	of	of	ADP
admet-1465	173	24	test	test	NOUN
admet-1465	173	25	solution	solution	NOUN
admet-1465	173	26	is	be	AUX
admet-1465	173	27	used	use	VERB
admet-1465	173	28	(	(	PUNCT
admet-1465	173	29	figure	figure	NOUN
admet-1465	173	30	2	2	NUM
admet-1465	173	31	)	)	PUNCT
admet-1465	173	32	.	.	PUNCT
admet-1465	174	1	figure	figure	VERB
admet-1465	174	2	6	6	NUM
admet-1465	174	3	.	.	PUNCT
admet-1465	175	1	ivr	ivr	PROPN
admet-1465	175	2	profiles	profile	NOUN
admet-1465	175	3	using	use	VERB
admet-1465	175	4	1.0	1.0	NUM
admet-1465	175	5	ml	ml	NOUN
admet-1465	175	6	(	(	PUNCT
admet-1465	175	7	solid	solid	ADJ
admet-1465	175	8	line	line	NOUN
admet-1465	175	9	)	)	PUNCT
admet-1465	175	10	and	and	CCONJ
admet-1465	175	11	0.5	0.5	NUM
admet-1465	175	12	ml	ml	NOUN
admet-1465	175	13	(	(	PUNCT
admet-1465	175	14	dashed	dash	VERB
admet-1465	175	15	line	line	NOUN
admet-1465	175	16	)	)	PUNCT
admet-1465	175	17	of	of	ADP
admet-1465	175	18	test	test	NOUN
admet-1465	175	19	solutions	solution	NOUN
admet-1465	175	20	for	for	ADP
admet-1465	175	21	isopropanol	isopropanol	NOUN
admet-1465	175	22	(	(	PUNCT
admet-1465	175	23	orange	orange	ADJ
admet-1465	175	24	)	)	PUNCT
admet-1465	175	25	and	and	CCONJ
admet-1465	175	26	capryol	capryol	ADV
admet-1465	175	27	®	®	NOUN
admet-1465	175	28	90	90	NUM
admet-1465	175	29	(	(	PUNCT
admet-1465	175	30	blue	blue	ADJ
admet-1465	175	31	)	)	PUNCT
admet-1465	175	32	test	test	NOUN
admet-1465	175	33	solutions	solution	NOUN
admet-1465	175	34	.	.	PUNCT
admet-1465	176	1	other	other	ADJ
admet-1465	176	2	test	test	NOUN
admet-1465	176	3	parameters	parameter	NOUN
admet-1465	176	4	:	:	PUNCT
admet-1465	176	5	rc	rc	PROPN
admet-1465	176	6	membranes	membrane	NOUN
admet-1465	176	7	,	,	PUNCT
admet-1465	176	8	37	37	NUM
admet-1465	176	9	°	°	NOUN
admet-1465	176	10	c	c	NOUN
admet-1465	176	11	,	,	PUNCT
admet-1465	176	12	75	75	NUM
admet-1465	176	13	rpm	rpm	NOUN
admet-1465	176	14	,	,	PUNCT
admet-1465	176	15	500	500	NUM
admet-1465	176	16	ml	ml	NOUN
admet-1465	176	17	of	of	ADP
admet-1465	176	18	phosphate	phosphate	ADJ
admet-1465	176	19	buffer	buffer	NOUN
admet-1465	176	20	ph	ph	VERB
admet-1465	176	21	7.4	7.4	NUM
admet-1465	176	22	release	release	NOUN
admet-1465	176	23	medium	medium	NOUN
admet-1465	176	24	.	.	PUNCT
admet-1465	177	1	error	error	NOUN
admet-1465	177	2	bars	bar	NOUN
admet-1465	177	3	represent	represent	VERB
admet-1465	177	4	standard	standard	ADJ
admet-1465	177	5	deviation	deviation	NOUN
admet-1465	177	6	,	,	PUNCT
admet-1465	177	7	n=3	n=3	NOUN
admet-1465	177	8	.	.	NOUN
admet-1465	178	1	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	178	2	filip	filip	PROPN
admet-1465	178	3	kozlina	kozlina	PROPN
admet-1465	178	4	et	et	PROPN
admet-1465	178	5	al	al	PROPN
admet-1465	178	6	.	.	PROPN
admet-1465	178	7	admet	admet	PROPN
admet-1465	178	8	&	&	CCONJ
admet-1465	178	9	dmpk	dmpk	PROPN
admet-1465	178	10	10(4	10(4	NUM
admet-1465	178	11	)	)	PUNCT
admet-1465	178	12	(	(	PUNCT
admet-1465	178	13	2022	2022	NUM
admet-1465	178	14	)	)	PUNCT
admet-1465	178	15	315	315	NUM
admet-1465	178	16	-	-	SYM
admet-1465	178	17	329	329	NUM
admet-1465	178	18	324	324	NUM
admet-1465	178	19	complete	complete	ADJ
admet-1465	178	20	ivr	ivr	NOUN
admet-1465	178	21	profiles	profile	NOUN
admet-1465	178	22	using	use	VERB
admet-1465	178	23	the	the	DET
admet-1465	178	24	optimized	optimize	VERB
admet-1465	178	25	test	test	NOUN
admet-1465	178	26	parameters	parameter	NOUN
admet-1465	178	27	method	method	VERB
admet-1465	178	28	development	development	NOUN
admet-1465	178	29	results	result	NOUN
admet-1465	178	30	indicate	indicate	VERB
admet-1465	178	31	that	that	SCONJ
admet-1465	178	32	the	the	DET
admet-1465	178	33	method	method	NOUN
admet-1465	178	34	is	be	AUX
admet-1465	178	35	sensitive	sensitive	ADJ
admet-1465	178	36	to	to	ADP
admet-1465	178	37	temperature	temperature	NOUN
admet-1465	178	38	and	and	CCONJ
admet-1465	178	39	moderately	moderately	ADV
admet-1465	178	40	to	to	ADP
admet-1465	178	41	stirring	stir	VERB
admet-1465	178	42	rate	rate	NOUN
admet-1465	178	43	but	but	CCONJ
admet-1465	178	44	not	not	PART
admet-1465	178	45	to	to	ADP
admet-1465	178	46	other	other	ADJ
admet-1465	178	47	evaluated	evaluated	ADJ
admet-1465	178	48	parameters	parameter	NOUN
admet-1465	178	49	.	.	PUNCT
admet-1465	179	1	additional	additional	ADJ
admet-1465	179	2	analyses	analysis	NOUN
admet-1465	179	3	were	be	AUX
admet-1465	179	4	performed	perform	VERB
admet-1465	179	5	with	with	ADP
admet-1465	179	6	both	both	DET
admet-1465	179	7	test	test	NOUN
admet-1465	179	8	solutions	solution	NOUN
admet-1465	179	9	to	to	PART
admet-1465	179	10	determine	determine	VERB
admet-1465	179	11	the	the	DET
admet-1465	179	12	method	method	NOUN
admet-1465	179	13	reproducibility	reproducibility	NOUN
admet-1465	179	14	and	and	CCONJ
admet-1465	179	15	overall	overall	ADJ
admet-1465	179	16	length	length	NOUN
admet-1465	179	17	of	of	ADP
admet-1465	179	18	the	the	DET
admet-1465	179	19	test	test	NOUN
admet-1465	179	20	required	require	VERB
admet-1465	179	21	to	to	PART
admet-1465	179	22	observe	observe	VERB
admet-1465	179	23	the	the	DET
admet-1465	179	24	complete	complete	ADJ
admet-1465	179	25	release	release	NOUN
admet-1465	179	26	of	of	ADP
admet-1465	179	27	the	the	DET
admet-1465	179	28	drug	drug	NOUN
admet-1465	179	29	.	.	PUNCT
admet-1465	180	1	since	since	SCONJ
admet-1465	180	2	the	the	DET
admet-1465	180	3	main	main	ADJ
admet-1465	180	4	purpose	purpose	NOUN
admet-1465	180	5	for	for	ADP
admet-1465	180	6	using	use	VERB
admet-1465	180	7	dialysis	dialysis	NOUN
admet-1465	180	8	membrane	membrane	NOUN
admet-1465	180	9	in	in	ADP
admet-1465	180	10	our	our	PRON
admet-1465	180	11	method	method	NOUN
admet-1465	180	12	was	be	AUX
admet-1465	180	13	avoiding	avoid	VERB
admet-1465	180	14	interference	interference	NOUN
admet-1465	180	15	from	from	ADP
admet-1465	180	16	formulation	formulation	NOUN
admet-1465	180	17	excipients	excipient	NOUN
admet-1465	180	18	and	and	CCONJ
admet-1465	180	19	mimicking	mimic	VERB
admet-1465	180	20	of	of	ADP
admet-1465	180	21	oil	oil	NOUN
admet-1465	180	22	depot	depot	NOUN
admet-1465	180	23	that	that	PRON
admet-1465	180	24	forms	form	NOUN
admet-1465	180	25	after	after	ADP
admet-1465	180	26	administration	administration	NOUN
admet-1465	180	27	in	in	ADP
admet-1465	180	28	vivo	vivo	NOUN
admet-1465	180	29	,	,	PUNCT
admet-1465	180	30	we	we	PRON
admet-1465	180	31	did	do	AUX
admet-1465	180	32	n’t	not	PART
admet-1465	180	33	want	want	VERB
admet-1465	180	34	the	the	DET
admet-1465	180	35	choice	choice	NOUN
admet-1465	180	36	of	of	ADP
admet-1465	180	37	dialysis	dialysis	NOUN
admet-1465	180	38	membrane	membrane	NOUN
admet-1465	180	39	type	type	NOUN
admet-1465	180	40	to	to	PART
admet-1465	180	41	be	be	AUX
admet-1465	180	42	a	a	DET
admet-1465	180	43	rate	rate	NOUN
admet-1465	180	44	-	-	PUNCT
admet-1465	180	45	limiting	limit	VERB
admet-1465	180	46	factor	factor	NOUN
admet-1465	180	47	.	.	PUNCT
admet-1465	181	1	based	base	VERB
admet-1465	181	2	on	on	ADP
admet-1465	181	3	the	the	DET
admet-1465	181	4	results	result	NOUN
admet-1465	181	5	observed	observe	VERB
admet-1465	181	6	between	between	ADP
admet-1465	181	7	the	the	DET
admet-1465	181	8	profiles	profile	NOUN
admet-1465	181	9	when	when	SCONJ
admet-1465	181	10	comparing	compare	VERB
admet-1465	181	11	the	the	DET
admet-1465	181	12	two	two	NUM
admet-1465	181	13	types	type	NOUN
admet-1465	181	14	of	of	ADP
admet-1465	181	15	membranes	membrane	NOUN
admet-1465	181	16	,	,	PUNCT
admet-1465	181	17	and	and	CCONJ
admet-1465	181	18	due	due	ADP
admet-1465	181	19	to	to	ADP
admet-1465	181	20	their	their	PRON
admet-1465	181	21	easier	easy	ADJ
admet-1465	181	22	handling	handling	NOUN
admet-1465	181	23	,	,	PUNCT
admet-1465	181	24	ce	ce	PROPN
admet-1465	181	25	membranes	membrane	NOUN
admet-1465	181	26	were	be	AUX
admet-1465	181	27	chosen	choose	VERB
admet-1465	181	28	as	as	ADP
admet-1465	181	29	a	a	DET
admet-1465	181	30	better	well	ADJ
admet-1465	181	31	option	option	NOUN
admet-1465	181	32	for	for	ADP
admet-1465	181	33	the	the	DET
admet-1465	181	34	ivr	ivr	PROPN
admet-1465	181	35	testing	testing	NOUN
admet-1465	181	36	method	method	NOUN
admet-1465	181	37	.	.	PUNCT
admet-1465	182	1	the	the	DET
admet-1465	182	2	test	test	NOUN
admet-1465	182	3	parameters	parameter	NOUN
admet-1465	182	4	used	use	VERB
admet-1465	182	5	were	be	AUX
admet-1465	182	6	as	as	SCONJ
admet-1465	182	7	follows	follow	VERB
admet-1465	182	8	:	:	PUNCT
admet-1465	182	9	ce	ce	PROPN
admet-1465	182	10	membranes	membrane	NOUN
admet-1465	182	11	,	,	PUNCT
admet-1465	182	12	37	37	NUM
admet-1465	182	13	°	°	NOUN
admet-1465	182	14	c	c	NOUN
admet-1465	182	15	(	(	PUNCT
admet-1465	182	16	physiological	physiological	ADJ
admet-1465	182	17	temperature	temperature	NOUN
admet-1465	182	18	,	,	PUNCT
admet-1465	182	19	higher	high	ADJ
admet-1465	182	20	release	release	NOUN
admet-1465	182	21	rate	rate	NOUN
admet-1465	182	22	compared	compare	VERB
admet-1465	182	23	to	to	ADP
admet-1465	182	24	25	25	NUM
admet-1465	182	25	°	°	NOUN
admet-1465	182	26	c	c	NOUN
admet-1465	182	27	)	)	PUNCT
admet-1465	182	28	,	,	PUNCT
admet-1465	182	29	phosphate	phosphate	NOUN
admet-1465	182	30	buffer	buffer	NOUN
admet-1465	182	31	(	(	PUNCT
admet-1465	182	32	ph	ph	NOUN
admet-1465	182	33	7.4	7.4	NUM
admet-1465	182	34	)	)	PUNCT
admet-1465	182	35	as	as	ADP
admet-1465	182	36	release	release	NOUN
admet-1465	182	37	medium	medium	NOUN
admet-1465	182	38	(	(	PUNCT
admet-1465	182	39	biorelevant	biorelevant	NOUN
admet-1465	182	40	regarding	regard	VERB
admet-1465	182	41	ph	ph	NOUN
admet-1465	182	42	,	,	PUNCT
admet-1465	182	43	ensuring	ensure	VERB
admet-1465	182	44	faster	fast	ADJ
admet-1465	182	45	release	release	NOUN
admet-1465	182	46	compared	compare	VERB
admet-1465	182	47	to	to	ADP
admet-1465	182	48	ethanol	ethanol	NOUN
admet-1465	182	49	-	-	PUNCT
admet-1465	182	50	containing	contain	VERB
admet-1465	182	51	medium	medium	NOUN
admet-1465	182	52	)	)	PUNCT
admet-1465	182	53	,	,	PUNCT
admet-1465	182	54	and	and	CCONJ
admet-1465	182	55	75	75	NUM
admet-1465	182	56	rpm	rpm	NOUN
admet-1465	182	57	stirring	stirring	NOUN
admet-1465	182	58	rate	rate	NOUN
admet-1465	182	59	(	(	PUNCT
admet-1465	182	60	ensuring	ensure	VERB
admet-1465	182	61	moderately	moderately	ADV
admet-1465	182	62	higher	high	ADJ
admet-1465	182	63	release	release	NOUN
admet-1465	182	64	rates	rate	NOUN
admet-1465	182	65	compared	compare	VERB
admet-1465	182	66	to	to	ADP
admet-1465	182	67	50	50	NUM
admet-1465	182	68	rpm	rpm	NOUN
admet-1465	182	69	)	)	PUNCT
admet-1465	182	70	.	.	PUNCT
admet-1465	183	1	1	1	NUM
admet-1465	183	2	ml	ml	NOUN
admet-1465	183	3	of	of	ADP
admet-1465	183	4	each	each	DET
admet-1465	183	5	test	test	NOUN
admet-1465	183	6	solution	solution	NOUN
admet-1465	183	7	was	be	AUX
admet-1465	183	8	added	add	VERB
admet-1465	183	9	to	to	ADP
admet-1465	183	10	a	a	DET
admet-1465	183	11	dialysis	dialysis	NOUN
admet-1465	183	12	bag	bag	NOUN
admet-1465	183	13	.	.	PUNCT
admet-1465	184	1	dex	dex	NOUN
admet-1465	184	2	release	release	NOUN
admet-1465	184	3	up	up	ADP
admet-1465	184	4	to	to	PART
admet-1465	184	5	48	48	NUM
admet-1465	184	6	hours	hour	NOUN
admet-1465	184	7	for	for	ADP
admet-1465	184	8	both	both	DET
admet-1465	184	9	test	test	NOUN
admet-1465	184	10	solutions	solution	NOUN
admet-1465	184	11	is	be	AUX
admet-1465	184	12	shown	show	VERB
admet-1465	184	13	in	in	ADP
admet-1465	184	14	figure	figure	NOUN
admet-1465	184	15	7	7	NUM
admet-1465	184	16	.	.	PUNCT
admet-1465	184	17	figure	figure	NOUN
admet-1465	184	18	7	7	NUM
admet-1465	184	19	.	.	PUNCT
admet-1465	184	20	complete	complete	PROPN
admet-1465	184	21	dex	dex	PROPN
admet-1465	184	22	ivr	ivr	PROPN
admet-1465	184	23	profiles	profile	NOUN
admet-1465	184	24	for	for	ADP
admet-1465	184	25	capryol	capryol	NOUN
admet-1465	184	26	®	®	NOUN
admet-1465	184	27	90	90	NUM
admet-1465	184	28	(	(	PUNCT
admet-1465	184	29	blue	blue	ADJ
admet-1465	184	30	)	)	PUNCT
admet-1465	184	31	and	and	CCONJ
admet-1465	184	32	isopropanol	isopropanol	NOUN
admet-1465	184	33	(	(	PUNCT
admet-1465	184	34	orange	orange	NOUN
admet-1465	184	35	)	)	PUNCT
admet-1465	184	36	containing	contain	VERB
admet-1465	184	37	test	test	NOUN
admet-1465	184	38	solutions	solution	NOUN
admet-1465	184	39	in	in	ADP
admet-1465	184	40	castor	castor	NOUN
admet-1465	184	41	oil	oil	NOUN
admet-1465	184	42	.	.	PUNCT
admet-1465	185	1	test	test	NOUN
admet-1465	185	2	parameters	parameter	NOUN
admet-1465	185	3	:	:	PUNCT
admet-1465	185	4	ce	ce	PROPN
admet-1465	185	5	membranes	membrane	NOUN
admet-1465	185	6	,	,	PUNCT
admet-1465	185	7	37	37	NUM
admet-1465	185	8	°	°	NOUN
admet-1465	185	9	c	c	NOUN
admet-1465	185	10	,	,	PUNCT
admet-1465	185	11	75	75	NUM
admet-1465	185	12	rpm	rpm	NOUN
admet-1465	185	13	,	,	PUNCT
admet-1465	185	14	1	1	NUM
admet-1465	185	15	ml	ml	NOUN
admet-1465	185	16	sample	sample	NOUN
admet-1465	185	17	volume	volume	NOUN
admet-1465	185	18	,	,	PUNCT
admet-1465	185	19	500	500	NUM
admet-1465	185	20	ml	ml	NOUN
admet-1465	185	21	of	of	ADP
admet-1465	185	22	phosphate	phosphate	ADJ
admet-1465	185	23	buffer	buffer	NOUN
admet-1465	185	24	ph	ph	VERB
admet-1465	185	25	7.4	7.4	NUM
admet-1465	185	26	release	release	NOUN
admet-1465	185	27	medium	medium	NOUN
admet-1465	185	28	.	.	PUNCT
admet-1465	186	1	error	error	NOUN
admet-1465	186	2	bars	bar	NOUN
admet-1465	186	3	represent	represent	VERB
admet-1465	186	4	standard	standard	ADJ
admet-1465	186	5	deviation	deviation	NOUN
admet-1465	186	6	,	,	PUNCT
admet-1465	186	7	n=6	n=6	NOUN
admet-1465	186	8	.	.	PUNCT
admet-1465	187	1	during	during	ADP
admet-1465	187	2	the	the	DET
admet-1465	187	3	first	first	ADJ
admet-1465	187	4	few	few	ADJ
admet-1465	187	5	hours	hour	NOUN
admet-1465	187	6	of	of	ADP
admet-1465	187	7	testing	testing	NOUN
admet-1465	187	8	,	,	PUNCT
admet-1465	187	9	dex	dex	PROPN
admet-1465	187	10	is	be	AUX
admet-1465	187	11	released	release	VERB
admet-1465	187	12	at	at	ADP
admet-1465	187	13	a	a	DET
admet-1465	187	14	higher	high	ADJ
admet-1465	187	15	rate	rate	NOUN
admet-1465	187	16	than	than	ADP
admet-1465	187	17	in	in	ADP
admet-1465	187	18	the	the	DET
admet-1465	187	19	later	later	ADJ
admet-1465	187	20	ones	one	NOUN
admet-1465	187	21	.	.	PUNCT
admet-1465	188	1	in	in	ADP
admet-1465	188	2	the	the	DET
admet-1465	188	3	period	period	NOUN
admet-1465	188	4	between	between	ADP
admet-1465	188	5	6	6	NUM
admet-1465	188	6	and	and	CCONJ
admet-1465	188	7	12	12	NUM
admet-1465	188	8	hours	hour	NOUN
admet-1465	188	9	,	,	PUNCT
admet-1465	188	10	a	a	DET
admet-1465	188	11	change	change	NOUN
admet-1465	188	12	in	in	ADP
admet-1465	188	13	the	the	DET
admet-1465	188	14	curve	curve	NOUN
admet-1465	188	15	slope	slope	NOUN
admet-1465	188	16	can	can	AUX
admet-1465	188	17	be	be	AUX
admet-1465	188	18	observed	observe	VERB
admet-1465	188	19	,	,	PUNCT
admet-1465	188	20	indicating	indicate	VERB
admet-1465	188	21	a	a	DET
admet-1465	188	22	point	point	NOUN
admet-1465	188	23	at	at	ADP
admet-1465	188	24	which	which	PRON
admet-1465	188	25	dex	dex	NOUN
admet-1465	188	26	release	release	NOUN
admet-1465	188	27	becomes	become	VERB
admet-1465	188	28	nearly	nearly	ADV
admet-1465	188	29	linear	linear	ADJ
admet-1465	188	30	.	.	PUNCT
admet-1465	189	1	these	these	DET
admet-1465	189	2	two	two	NUM
admet-1465	189	3	phases	phase	NOUN
admet-1465	189	4	in	in	ADP
admet-1465	189	5	the	the	DET
admet-1465	189	6	ivr	ivr	PROPN
admet-1465	189	7	profiles	profile	NOUN
admet-1465	189	8	are	be	AUX
admet-1465	189	9	a	a	DET
admet-1465	189	10	consequence	consequence	NOUN
admet-1465	189	11	of	of	ADP
admet-1465	189	12	the	the	DET
admet-1465	189	13	physicochemical	physicochemical	ADJ
admet-1465	189	14	properties	property	NOUN
admet-1465	189	15	of	of	ADP
admet-1465	189	16	the	the	DET
admet-1465	189	17	cosolvent	cosolvent	NOUN
admet-1465	189	18	,	,	PUNCT
admet-1465	189	19	which	which	PRON
admet-1465	189	20	is	be	AUX
admet-1465	189	21	well	well	ADV
admet-1465	189	22	soluble	soluble	ADJ
admet-1465	189	23	both	both	PRON
admet-1465	189	24	in	in	ADP
admet-1465	189	25	the	the	DET
admet-1465	189	26	oil	oil	NOUN
admet-1465	189	27	and	and	CCONJ
admet-1465	189	28	the	the	DET
admet-1465	189	29	aqueous	aqueous	ADJ
admet-1465	189	30	phase	phase	NOUN
admet-1465	189	31	(	(	PUNCT
admet-1465	189	32	in	in	ADP
admet-1465	189	33	the	the	DET
admet-1465	189	34	case	case	NOUN
admet-1465	189	35	of	of	ADP
admet-1465	189	36	isopropanol	isopropanol	NOUN
admet-1465	189	37	,	,	PUNCT
admet-1465	189	38	the	the	DET
admet-1465	189	39	solubility	solubility	NOUN
admet-1465	189	40	of	of	ADP
admet-1465	189	41	the	the	DET
admet-1465	189	42	cosolvent	cosolvent	NOUN
admet-1465	189	43	is	be	AUX
admet-1465	189	44	even	even	ADV
admet-1465	189	45	higher	high	ADJ
admet-1465	189	46	in	in	ADP
admet-1465	189	47	the	the	DET
admet-1465	189	48	release	release	NOUN
admet-1465	189	49	medium	medium	NOUN
admet-1465	189	50	)	)	PUNCT
admet-1465	189	51	.	.	PUNCT
admet-1465	190	1	this	this	PRON
admet-1465	190	2	leads	lead	VERB
admet-1465	190	3	to	to	ADP
admet-1465	190	4	a	a	DET
admet-1465	190	5	release	release	NOUN
admet-1465	190	6	of	of	ADP
admet-1465	190	7	the	the	DET
admet-1465	190	8	cosolvent	cosolvent	NOUN
admet-1465	190	9	into	into	ADP
admet-1465	190	10	the	the	DET
admet-1465	190	11	release	release	NOUN
admet-1465	190	12	medium	medium	NOUN
admet-1465	190	13	(	(	PUNCT
admet-1465	190	14	alongside	alongside	ADP
admet-1465	190	15	the	the	DET
admet-1465	190	16	drug	drug	NOUN
admet-1465	190	17	)	)	PUNCT
admet-1465	190	18	with	with	ADP
admet-1465	190	19	kinetics	kinetic	NOUN
admet-1465	190	20	different	different	ADJ
admet-1465	190	21	from	from	ADP
admet-1465	190	22	those	those	PRON
admet-1465	190	23	observed	observe	VERB
admet-1465	190	24	for	for	ADP
admet-1465	190	25	the	the	DET
admet-1465	190	26	release	release	NOUN
admet-1465	190	27	of	of	ADP
admet-1465	190	28	dex	dex	NOUN
admet-1465	190	29	alone	alone	ADV
admet-1465	190	30	.	.	PUNCT
admet-1465	191	1	since	since	SCONJ
admet-1465	191	2	the	the	DET
admet-1465	191	3	solubility	solubility	NOUN
admet-1465	191	4	of	of	ADP
admet-1465	191	5	isopropanol	isopropanol	NOUN
admet-1465	191	6	in	in	ADP
admet-1465	191	7	the	the	DET
admet-1465	191	8	release	release	NOUN
admet-1465	191	9	medium	medium	NOUN
admet-1465	191	10	is	be	AUX
admet-1465	191	11	significantly	significantly	ADV
admet-1465	191	12	higher	high	ADJ
admet-1465	191	13	than	than	ADP
admet-1465	191	14	the	the	DET
admet-1465	191	15	solubility	solubility	NOUN
admet-1465	191	16	of	of	ADP
admet-1465	191	17	dex	dex	NOUN
admet-1465	191	18	,	,	PUNCT
admet-1465	191	19	its	its	PRON
admet-1465	191	20	release	release	NOUN
admet-1465	191	21	is	be	AUX
admet-1465	191	22	faster	fast	ADJ
admet-1465	191	23	than	than	ADP
admet-1465	191	24	the	the	DET
admet-1465	191	25	release	release	NOUN
admet-1465	191	26	of	of	ADP
admet-1465	191	27	dex	dex	NOUN
admet-1465	191	28	in	in	ADP
admet-1465	191	29	the	the	DET
admet-1465	191	30	first	first	ADJ
admet-1465	191	31	hours	hour	NOUN
admet-1465	191	32	,	,	PUNCT
admet-1465	191	33	during	during	ADP
admet-1465	191	34	which	which	PRON
admet-1465	191	35	virtually	virtually	ADV
admet-1465	191	36	all	all	DET
admet-1465	191	37	isopropanol	isopropanol	NOUN
admet-1465	191	38	becomes	becomes	AUX
admet-1465	191	39	released	release	VERB
admet-1465	191	40	to	to	ADP
admet-1465	191	41	the	the	DET
admet-1465	191	42	medium	medium	NOUN
admet-1465	191	43	.	.	PUNCT
admet-1465	192	1	consequently	consequently	ADV
admet-1465	192	2	,	,	PUNCT
admet-1465	192	3	the	the	DET
admet-1465	192	4	partitioning	partitioning	ADJ
admet-1465	192	5	coefficient	coefficient	NOUN
admet-1465	192	6	changes	change	VERB
admet-1465	192	7	over	over	ADP
admet-1465	192	8	time	time	NOUN
admet-1465	192	9	.	.	PUNCT
admet-1465	193	1	when	when	SCONJ
admet-1465	193	2	the	the	DET
admet-1465	193	3	rate	rate	NOUN
admet-1465	193	4	of	of	ADP
admet-1465	193	5	isopropanol	isopropanol	NOUN
admet-1465	193	6	release	release	NOUN
admet-1465	193	7	becomes	become	VERB
admet-1465	193	8	constant	constant	ADJ
admet-1465	193	9	or	or	CCONJ
admet-1465	193	10	all	all	DET
admet-1465	193	11	isopropanol	isopropanol	NOUN
admet-1465	193	12	is	be	AUX
admet-1465	193	13	released	release	VERB
admet-1465	193	14	,	,	PUNCT
admet-1465	193	15	dex	dex	NOUN
admet-1465	193	16	's	's	PART
admet-1465	193	17	solubility	solubility	NOUN
admet-1465	193	18	and	and	CCONJ
admet-1465	193	19	partitioning	partition	VERB
admet-1465	193	20	admet	admet	PROPN
admet-1465	193	21	&	&	CCONJ
admet-1465	193	22	dmpk	dmpk	PROPN
admet-1465	193	23	10(4	10(4	NUM
admet-1465	193	24	)	)	PUNCT
admet-1465	193	25	(	(	PUNCT
admet-1465	193	26	2022	2022	NUM
admet-1465	193	27	)	)	PUNCT
admet-1465	193	28	315	315	NUM
admet-1465	193	29	-	-	SYM
admet-1465	193	30	329	329	NUM
admet-1465	193	31	dexamethasone	dexamethasone	NOUN
admet-1465	193	32	release	release	NOUN
admet-1465	193	33	from	from	ADP
admet-1465	193	34	the	the	DET
admet-1465	193	35	oil	oil	NOUN
admet-1465	193	36	solutions	solution	NOUN
admet-1465	193	37	doi	doi	NOUN
admet-1465	193	38	:	:	PUNCT
admet-1465	193	39	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	193	40	325	325	NUM
admet-1465	193	41	coefficient	coefficient	NOUN
admet-1465	193	42	become	become	VERB
admet-1465	193	43	constant	constant	ADJ
admet-1465	193	44	,	,	PUNCT
admet-1465	193	45	leading	lead	VERB
admet-1465	193	46	to	to	ADP
admet-1465	193	47	a	a	DET
admet-1465	193	48	linear	linear	ADJ
admet-1465	193	49	terminal	terminal	ADJ
admet-1465	193	50	phase	phase	NOUN
admet-1465	193	51	of	of	ADP
admet-1465	193	52	dex	dex	NOUN
admet-1465	193	53	release	release	NOUN
admet-1465	193	54	.	.	PUNCT
admet-1465	194	1	furthermore	furthermore	ADV
admet-1465	194	2	,	,	PUNCT
admet-1465	194	3	this	this	DET
admet-1465	194	4	linearity	linearity	NOUN
admet-1465	194	5	is	be	AUX
admet-1465	194	6	maintained	maintain	VERB
admet-1465	194	7	by	by	ADP
admet-1465	194	8	a	a	DET
admet-1465	194	9	constant	constant	ADJ
admet-1465	194	10	concentration	concentration	NOUN
admet-1465	194	11	gradient	gradient	NOUN
admet-1465	194	12	,	,	PUNCT
admet-1465	194	13	which	which	PRON
admet-1465	194	14	is	be	AUX
admet-1465	194	15	guaranteed	guarantee	VERB
admet-1465	194	16	by	by	ADP
admet-1465	194	17	design	design	NOUN
admet-1465	194	18	in	in	ADP
admet-1465	194	19	this	this	DET
admet-1465	194	20	method	method	NOUN
admet-1465	194	21	,	,	PUNCT
admet-1465	194	22	where	where	SCONJ
admet-1465	194	23	sink	sink	NOUN
admet-1465	194	24	conditions	condition	NOUN
admet-1465	194	25	are	be	AUX
admet-1465	194	26	ensured	ensure	VERB
admet-1465	194	27	throughout	throughout	ADP
admet-1465	194	28	the	the	DET
admet-1465	194	29	experiment	experiment	NOUN
admet-1465	194	30	.	.	PUNCT
admet-1465	195	1	release	release	VERB
admet-1465	195	2	kinetics	kinetic	NOUN
admet-1465	195	3	from	from	ADP
admet-1465	195	4	the	the	DET
admet-1465	195	5	oil	oil	NOUN
admet-1465	195	6	phase	phase	NOUN
admet-1465	195	7	to	to	ADP
admet-1465	195	8	the	the	DET
admet-1465	195	9	oil	oil	NOUN
admet-1465	195	10	/	/	SYM
admet-1465	195	11	water	water	NOUN
admet-1465	195	12	interface	interface	NOUN
admet-1465	195	13	in	in	ADP
admet-1465	195	14	this	this	DET
admet-1465	195	15	type	type	NOUN
admet-1465	195	16	of	of	ADP
admet-1465	195	17	delivery	delivery	NOUN
admet-1465	195	18	system	system	NOUN
admet-1465	195	19	is	be	AUX
admet-1465	195	20	affected	affect	VERB
admet-1465	195	21	by	by	ADP
admet-1465	195	22	drug	drug	NOUN
admet-1465	195	23	diffusivity	diffusivity	NOUN
admet-1465	195	24	in	in	ADP
admet-1465	195	25	the	the	DET
admet-1465	195	26	oil	oil	NOUN
admet-1465	195	27	as	as	ADV
admet-1465	195	28	well	well	ADV
admet-1465	195	29	as	as	ADP
admet-1465	195	30	convection	convection	NOUN
admet-1465	195	31	induced	induce	VERB
admet-1465	195	32	by	by	ADP
admet-1465	195	33	stirring	stir	VERB
admet-1465	195	34	in	in	ADP
admet-1465	195	35	the	the	DET
admet-1465	195	36	aqueous	aqueous	ADJ
admet-1465	195	37	phase	phase	NOUN
admet-1465	195	38	[	[	X
admet-1465	195	39	22	22	NUM
admet-1465	195	40	]	]	PUNCT
admet-1465	195	41	.	.	PUNCT
admet-1465	196	1	ivr	ivr	PROPN
admet-1465	196	2	setup	setup	NOUN
admet-1465	196	3	does	do	AUX
admet-1465	196	4	have	have	VERB
admet-1465	196	5	an	an	DET
admet-1465	196	6	influence	influence	NOUN
admet-1465	196	7	on	on	ADP
admet-1465	196	8	the	the	DET
admet-1465	196	9	convection	convection	NOUN
admet-1465	196	10	process	process	NOUN
admet-1465	196	11	.	.	PUNCT
admet-1465	197	1	however	however	ADV
admet-1465	197	2	,	,	PUNCT
admet-1465	197	3	the	the	DET
admet-1465	197	4	literature	literature	NOUN
admet-1465	197	5	predominantly	predominantly	ADV
admet-1465	197	6	reports	report	VERB
admet-1465	197	7	first	first	ADJ
admet-1465	197	8	-	-	PUNCT
admet-1465	197	9	order	order	NOUN
admet-1465	197	10	release	release	NOUN
admet-1465	197	11	for	for	ADP
admet-1465	197	12	oil	oil	NOUN
admet-1465	197	13	solutions	solution	NOUN
admet-1465	198	1	[	[	X
admet-1465	198	2	22,23	22,23	NOUN
admet-1465	198	3	]	]	X
admet-1465	198	4	,	,	PUNCT
admet-1465	198	5	which	which	PRON
admet-1465	198	6	is	be	AUX
admet-1465	198	7	also	also	ADV
admet-1465	198	8	valid	valid	ADJ
admet-1465	198	9	for	for	ADP
admet-1465	198	10	profiles	profile	NOUN
admet-1465	198	11	obtained	obtain	VERB
admet-1465	198	12	in	in	ADP
admet-1465	198	13	this	this	DET
admet-1465	198	14	study	study	NOUN
admet-1465	198	15	.	.	PUNCT
admet-1465	199	1	two	two	NUM
admet-1465	199	2	phases	phase	NOUN
admet-1465	199	3	of	of	ADP
admet-1465	199	4	release	release	NOUN
admet-1465	199	5	from	from	ADP
admet-1465	199	6	oil	oil	NOUN
admet-1465	199	7	formulations	formulation	NOUN
admet-1465	199	8	with	with	ADP
admet-1465	199	9	a	a	DET
admet-1465	199	10	hydrophilic	hydrophilic	ADJ
admet-1465	199	11	cosolvent	cosolvent	NOUN
admet-1465	199	12	were	be	AUX
admet-1465	199	13	also	also	ADV
admet-1465	199	14	observed	observe	VERB
admet-1465	199	15	in	in	ADP
admet-1465	199	16	vivo	vivo	NOUN
admet-1465	199	17	in	in	ADP
admet-1465	199	18	human	human	ADJ
admet-1465	199	19	blood	blood	NOUN
admet-1465	199	20	,	,	PUNCT
admet-1465	199	21	using	use	VERB
admet-1465	199	22	a	a	DET
admet-1465	199	23	solution	solution	NOUN
admet-1465	199	24	of	of	ADP
admet-1465	199	25	nandrolone	nandrolone	NOUN
admet-1465	199	26	decanoate	decanoate	NOUN
admet-1465	199	27	in	in	ADP
admet-1465	199	28	sesame	sesame	ADJ
admet-1465	199	29	oil	oil	NOUN
admet-1465	199	30	with	with	ADP
admet-1465	199	31	benzyl	benzyl	NOUN
admet-1465	199	32	alcohol	alcohol	NOUN
admet-1465	199	33	as	as	ADP
admet-1465	199	34	a	a	DET
admet-1465	199	35	cosolvent	cosolvent	NOUN
admet-1465	199	36	[	[	X
admet-1465	199	37	24	24	NUM
admet-1465	199	38	]	]	PUNCT
admet-1465	199	39	.	.	PUNCT
admet-1465	200	1	reported	report	VERB
admet-1465	200	2	biphasic	biphasic	ADJ
admet-1465	200	3	ivr	ivr	NOUN
admet-1465	200	4	profiles	profile	NOUN
admet-1465	200	5	nicely	nicely	ADV
admet-1465	200	6	fit	fit	VERB
admet-1465	200	7	observed	observed	ADJ
admet-1465	200	8	in	in	ADP
admet-1465	200	9	vivo	vivo	ADJ
admet-1465	200	10	pk	pk	NOUN
admet-1465	200	11	profiles	profile	NOUN
admet-1465	200	12	.	.	PUNCT
admet-1465	201	1	overall	overall	ADJ
admet-1465	201	2	reproducibility	reproducibility	NOUN
admet-1465	201	3	(	(	PUNCT
admet-1465	201	4	n	n	NOUN
admet-1465	201	5	=	=	SYM
admet-1465	201	6	6	6	NUM
admet-1465	201	7	,	,	PUNCT
admet-1465	201	8	from	from	ADP
admet-1465	201	9	two	two	NUM
admet-1465	201	10	different	different	ADJ
admet-1465	201	11	experiments	experiment	NOUN
admet-1465	201	12	)	)	PUNCT
admet-1465	201	13	was	be	AUX
admet-1465	201	14	achieved	achieve	VERB
admet-1465	201	15	,	,	PUNCT
admet-1465	201	16	quite	quite	ADV
admet-1465	201	17	acceptable	acceptable	ADJ
admet-1465	201	18	for	for	ADP
admet-1465	201	19	ivr	ivr	PROPN
admet-1465	201	20	method	method	NOUN
admet-1465	201	21	for	for	ADP
admet-1465	201	22	modified	modify	VERB
admet-1465	201	23	release	release	NOUN
admet-1465	201	24	products	product	NOUN
admet-1465	201	25	(	(	PUNCT
admet-1465	201	26	standard	standard	ADJ
admet-1465	201	27	deviation	deviation	NOUN
admet-1465	201	28	below	below	ADP
admet-1465	201	29	10	10	NUM
admet-1465	201	30	%	%	NOUN
admet-1465	201	31	up	up	ADP
admet-1465	201	32	to	to	ADP
admet-1465	201	33	48	48	NUM
admet-1465	201	34	or	or	CCONJ
admet-1465	201	35	24	24	NUM
admet-1465	201	36	hours	hour	NOUN
admet-1465	201	37	for	for	ADP
admet-1465	201	38	isopropanol	isopropanol	NOUN
admet-1465	201	39	and	and	CCONJ
admet-1465	201	40	capryol	capryol	NOUN
admet-1465	201	41	®	®	NOUN
admet-1465	201	42	90	90	NUM
admet-1465	201	43	test	test	NOUN
admet-1465	201	44	solution	solution	NOUN
admet-1465	201	45	,	,	PUNCT
admet-1465	201	46	respectively	respectively	ADV
admet-1465	201	47	)	)	PUNCT
admet-1465	201	48	.	.	PUNCT
admet-1465	202	1	in	in	ADP
admet-1465	202	2	addition	addition	NOUN
admet-1465	202	3	,	,	PUNCT
admet-1465	202	4	dex	dex	NOUN
admet-1465	202	5	release	release	NOUN
admet-1465	202	6	profiles	profile	NOUN
admet-1465	202	7	from	from	ADP
admet-1465	202	8	both	both	DET
admet-1465	202	9	test	test	NOUN
admet-1465	202	10	solutions	solution	NOUN
admet-1465	202	11	were	be	AUX
admet-1465	202	12	quite	quite	ADV
admet-1465	202	13	similar	similar	ADJ
admet-1465	202	14	up	up	ADP
admet-1465	202	15	to	to	PART
admet-1465	202	16	36	36	NUM
admet-1465	202	17	hours	hour	NOUN
admet-1465	202	18	,	,	PUNCT
admet-1465	202	19	indicating	indicate	VERB
admet-1465	202	20	that	that	SCONJ
admet-1465	202	21	the	the	DET
admet-1465	202	22	type	type	NOUN
admet-1465	202	23	of	of	ADP
admet-1465	202	24	cosolvent	cosolvent	NOUN
admet-1465	202	25	does	do	AUX
admet-1465	202	26	not	not	PART
admet-1465	202	27	affect	affect	VERB
admet-1465	202	28	the	the	DET
admet-1465	202	29	release	release	NOUN
admet-1465	202	30	rate	rate	NOUN
admet-1465	202	31	in	in	ADP
admet-1465	202	32	these	these	DET
admet-1465	202	33	conditions	condition	NOUN
admet-1465	202	34	.	.	PUNCT
admet-1465	203	1	on	on	ADP
admet-1465	203	2	the	the	DET
admet-1465	203	3	other	other	ADJ
admet-1465	203	4	hand	hand	NOUN
admet-1465	203	5	,	,	PUNCT
admet-1465	203	6	the	the	DET
admet-1465	203	7	obtained	obtain	VERB
admet-1465	203	8	dex	dex	NOUN
admet-1465	203	9	release	release	NOUN
admet-1465	203	10	profiles	profile	NOUN
admet-1465	203	11	(	(	PUNCT
admet-1465	203	12	figure	figure	NOUN
admet-1465	203	13	7	7	NUM
admet-1465	203	14	)	)	PUNCT
admet-1465	203	15	were	be	AUX
admet-1465	203	16	elevated	elevate	VERB
admet-1465	203	17	and	and	CCONJ
admet-1465	203	18	did	do	AUX
admet-1465	203	19	not	not	PART
admet-1465	203	20	show	show	VERB
admet-1465	203	21	a	a	DET
admet-1465	203	22	characteristic	characteristic	ADJ
admet-1465	203	23	plateau	plateau	NOUN
admet-1465	203	24	pattern	pattern	NOUN
admet-1465	203	25	around	around	ADP
admet-1465	203	26	100	100	NUM
admet-1465	203	27	%	%	NOUN
admet-1465	203	28	at	at	ADP
admet-1465	203	29	the	the	DET
admet-1465	203	30	final	final	ADJ
admet-1465	203	31	time	time	NOUN
admet-1465	203	32	points	point	NOUN
admet-1465	203	33	.	.	PUNCT
admet-1465	204	1	this	this	PRON
admet-1465	204	2	was	be	AUX
admet-1465	204	3	even	even	ADV
admet-1465	204	4	more	more	ADV
admet-1465	204	5	pronounced	pronounced	ADJ
admet-1465	204	6	at	at	ADP
admet-1465	204	7	time	time	NOUN
admet-1465	204	8	points	point	VERB
admet-1465	204	9	up	up	ADP
admet-1465	204	10	to	to	PART
admet-1465	204	11	72	72	NUM
admet-1465	204	12	hours	hour	NOUN
admet-1465	204	13	,	,	PUNCT
admet-1465	204	14	especially	especially	ADV
admet-1465	204	15	for	for	ADP
admet-1465	204	16	capryol	capryol	NOUN
admet-1465	204	17	®	®	VERB
admet-1465	204	18	90	90	NUM
admet-1465	204	19	test	test	NOUN
admet-1465	204	20	solution	solution	NOUN
admet-1465	204	21	(	(	PUNCT
admet-1465	204	22	data	datum	NOUN
admet-1465	204	23	not	not	PART
admet-1465	204	24	shown	show	VERB
admet-1465	204	25	)	)	PUNCT
admet-1465	204	26	.	.	PUNCT
admet-1465	205	1	since	since	SCONJ
admet-1465	205	2	that	that	PRON
admet-1465	205	3	was	be	AUX
admet-1465	205	4	an	an	DET
admet-1465	205	5	indicator	indicator	NOUN
admet-1465	205	6	of	of	ADP
admet-1465	205	7	interference	interference	NOUN
admet-1465	205	8	during	during	ADP
admet-1465	205	9	the	the	DET
admet-1465	205	10	absorbance	absorbance	NOUN
admet-1465	205	11	reading	read	VERB
admet-1465	205	12	with	with	ADP
admet-1465	205	13	optic	optic	ADJ
admet-1465	205	14	probes	probe	NOUN
admet-1465	205	15	,	,	PUNCT
admet-1465	205	16	this	this	DET
admet-1465	205	17	effect	effect	NOUN
admet-1465	205	18	was	be	AUX
admet-1465	205	19	further	far	ADV
admet-1465	205	20	studied	study	VERB
admet-1465	205	21	using	use	VERB
admet-1465	205	22	the	the	DET
admet-1465	205	23	isopropanol	isopropanol	NOUN
admet-1465	205	24	test	test	NOUN
admet-1465	205	25	solution	solution	NOUN
admet-1465	205	26	.	.	PUNCT
admet-1465	206	1	placebo	placebo	NOUN
admet-1465	206	2	interference	interference	NOUN
admet-1465	206	3	an	an	DET
admet-1465	206	4	additional	additional	ADJ
admet-1465	206	5	dissolution	dissolution	NOUN
admet-1465	206	6	experiment	experiment	NOUN
admet-1465	206	7	was	be	AUX
admet-1465	206	8	performed	perform	VERB
admet-1465	206	9	with	with	ADP
admet-1465	206	10	a	a	DET
admet-1465	206	11	placebo	placebo	NOUN
admet-1465	206	12	solution	solution	NOUN
admet-1465	206	13	containing	contain	VERB
admet-1465	206	14	only	only	ADV
admet-1465	206	15	castor	castor	NOUN
admet-1465	206	16	oil	oil	NOUN
admet-1465	206	17	and	and	CCONJ
admet-1465	206	18	isopropanol	isopropanol	NOUN
admet-1465	206	19	.	.	PUNCT
admet-1465	207	1	the	the	DET
admet-1465	207	2	obtained	obtain	VERB
admet-1465	207	3	absorbance	absorbance	NOUN
admet-1465	207	4	profile	profile	VERB
admet-1465	207	5	up	up	ADP
admet-1465	207	6	to	to	PART
admet-1465	207	7	72	72	NUM
admet-1465	207	8	hours	hour	NOUN
admet-1465	207	9	,	,	PUNCT
admet-1465	207	10	corresponding	correspond	VERB
admet-1465	207	11	to	to	ADP
admet-1465	207	12	the	the	DET
admet-1465	207	13	percent	percent	NOUN
admet-1465	207	14	of	of	ADP
admet-1465	207	15	released	release	VERB
admet-1465	207	16	dex	dex	NOUN
admet-1465	207	17	,	,	PUNCT
admet-1465	207	18	was	be	AUX
admet-1465	207	19	compared	compare	VERB
admet-1465	207	20	to	to	ADP
admet-1465	207	21	the	the	DET
admet-1465	207	22	dex	dex	NOUN
admet-1465	207	23	release	release	NOUN
admet-1465	207	24	profile	profile	NOUN
admet-1465	207	25	from	from	ADP
admet-1465	207	26	the	the	DET
admet-1465	207	27	test	test	NOUN
admet-1465	207	28	solution	solution	NOUN
admet-1465	207	29	(	(	PUNCT
admet-1465	207	30	figure	figure	NOUN
admet-1465	207	31	8)	8)	NUM
admet-1465	207	32	.	.	PUNCT
admet-1465	207	33	increased	increase	VERB
admet-1465	207	34	absorbance	absorbance	NOUN
admet-1465	207	35	of	of	ADP
admet-1465	207	36	placebo	placebo	NOUN
admet-1465	207	37	was	be	AUX
admet-1465	207	38	observed	observe	VERB
admet-1465	207	39	from	from	ADP
admet-1465	207	40	48	48	NUM
admet-1465	207	41	-	-	PUNCT
admet-1465	207	42	hour	hour	NOUN
admet-1465	207	43	time	time	NOUN
admet-1465	207	44	point	point	NOUN
admet-1465	207	45	,	,	PUNCT
admet-1465	207	46	indicating	indicate	VERB
admet-1465	207	47	a	a	DET
admet-1465	207	48	significant	significant	ADJ
admet-1465	207	49	effect	effect	NOUN
admet-1465	207	50	of	of	ADP
admet-1465	207	51	excipients	excipient	NOUN
admet-1465	207	52	from	from	ADP
admet-1465	207	53	formulation	formulation	NOUN
admet-1465	207	54	on	on	ADP
admet-1465	207	55	total	total	ADJ
admet-1465	207	56	absorbance	absorbance	NOUN
admet-1465	207	57	readout	readout	VERB
admet-1465	207	58	in	in	ADP
admet-1465	207	59	consecutive	consecutive	ADJ
admet-1465	207	60	time	time	NOUN
admet-1465	207	61	points	point	NOUN
admet-1465	207	62	.	.	PUNCT
admet-1465	208	1	the	the	DET
admet-1465	208	2	interference	interference	NOUN
admet-1465	208	3	from	from	ADP
admet-1465	208	4	the	the	DET
admet-1465	208	5	placebo	placebo	NOUN
admet-1465	208	6	is	be	AUX
admet-1465	208	7	probably	probably	ADV
admet-1465	208	8	caused	cause	VERB
admet-1465	208	9	by	by	ADP
admet-1465	208	10	components	component	NOUN
admet-1465	208	11	of	of	ADP
admet-1465	208	12	castor	castor	NOUN
admet-1465	208	13	oil	oil	NOUN
admet-1465	208	14	that	that	PRON
admet-1465	208	15	diffuse	diffuse	VERB
admet-1465	208	16	through	through	ADP
admet-1465	208	17	the	the	DET
admet-1465	208	18	dialysis	dialysis	NOUN
admet-1465	208	19	membrane	membrane	NOUN
admet-1465	208	20	at	at	ADP
admet-1465	208	21	later	later	ADJ
admet-1465	208	22	time	time	NOUN
admet-1465	208	23	points	point	NOUN
admet-1465	208	24	.	.	PUNCT
admet-1465	209	1	the	the	DET
admet-1465	209	2	absorbance	absorbance	NOUN
admet-1465	209	3	intensity	intensity	NOUN
admet-1465	209	4	is	be	AUX
admet-1465	209	5	more	more	ADV
admet-1465	209	6	pronounced	pronounced	ADJ
admet-1465	209	7	in	in	ADP
admet-1465	209	8	placebo	placebo	NOUN
admet-1465	209	9	alone	alone	ADV
admet-1465	209	10	compared	compare	VERB
admet-1465	209	11	to	to	ADP
admet-1465	209	12	the	the	DET
admet-1465	209	13	extent	extent	NOUN
admet-1465	209	14	of	of	ADP
admet-1465	209	15	interference	interference	NOUN
admet-1465	209	16	in	in	ADP
admet-1465	209	17	the	the	DET
admet-1465	209	18	test	test	NOUN
admet-1465	209	19	solution	solution	NOUN
admet-1465	209	20	.	.	PUNCT
admet-1465	210	1	that	that	PRON
admet-1465	210	2	could	could	AUX
admet-1465	210	3	be	be	AUX
admet-1465	210	4	attributed	attribute	VERB
admet-1465	210	5	to	to	ADP
admet-1465	210	6	the	the	DET
admet-1465	210	7	slower	slow	ADJ
admet-1465	210	8	diffusion	diffusion	NOUN
admet-1465	210	9	of	of	ADP
admet-1465	210	10	excipients	excipient	NOUN
admet-1465	210	11	from	from	ADP
admet-1465	210	12	the	the	DET
admet-1465	210	13	test	test	NOUN
admet-1465	210	14	solution	solution	NOUN
admet-1465	210	15	due	due	ADP
admet-1465	210	16	to	to	ADP
admet-1465	210	17	competition	competition	NOUN
admet-1465	210	18	with	with	ADP
admet-1465	210	19	faster	fast	ADJ
admet-1465	210	20	diffusing	diffuse	VERB
admet-1465	210	21	dex	dex	NOUN
admet-1465	210	22	.	.	PUNCT
admet-1465	211	1	since	since	SCONJ
admet-1465	211	2	the	the	DET
admet-1465	211	3	dialysis	dialysis	NOUN
admet-1465	211	4	membrane	membrane	NOUN
admet-1465	211	5	of	of	ADP
admet-1465	211	6	choice	choice	NOUN
admet-1465	211	7	for	for	ADP
admet-1465	211	8	performing	perform	VERB
admet-1465	211	9	the	the	DET
admet-1465	211	10	experiments	experiment	NOUN
admet-1465	211	11	was	be	AUX
admet-1465	211	12	the	the	DET
admet-1465	211	13	ce	ce	PROPN
admet-1465	211	14	membrane	membrane	NOUN
admet-1465	211	15	with	with	ADP
admet-1465	211	16	mwco	mwco	PROPN
admet-1465	211	17	300	300	NUM
admet-1465	211	18	kda	kda	NOUN
admet-1465	211	19	,	,	PUNCT
admet-1465	211	20	these	these	DET
admet-1465	211	21	interferences	interference	NOUN
admet-1465	211	22	could	could	AUX
admet-1465	211	23	probably	probably	ADV
admet-1465	211	24	have	have	AUX
admet-1465	211	25	been	be	AUX
admet-1465	211	26	reduced	reduce	VERB
admet-1465	211	27	to	to	ADP
admet-1465	211	28	a	a	DET
admet-1465	211	29	certain	certain	ADJ
admet-1465	211	30	extent	extent	NOUN
admet-1465	211	31	by	by	ADP
admet-1465	211	32	using	use	VERB
admet-1465	211	33	the	the	DET
admet-1465	211	34	rc	rc	PROPN
admet-1465	211	35	membrane	membrane	NOUN
admet-1465	211	36	with	with	ADP
admet-1465	211	37	mwco	mwco	NOUN
admet-1465	211	38	50	50	NUM
admet-1465	211	39	kda	kda	NOUN
admet-1465	211	40	.	.	PUNCT
admet-1465	212	1	instead	instead	ADV
admet-1465	212	2	,	,	PUNCT
admet-1465	212	3	the	the	DET
admet-1465	212	4	elimination	elimination	NOUN
admet-1465	212	5	of	of	ADP
admet-1465	212	6	interference	interference	NOUN
admet-1465	212	7	by	by	ADP
admet-1465	212	8	use	use	NOUN
admet-1465	212	9	of	of	ADP
admet-1465	212	10	derivative	derivative	ADJ
admet-1465	212	11	spectroscopy	spectroscopy	NOUN
admet-1465	212	12	is	be	AUX
admet-1465	212	13	described	describe	VERB
admet-1465	212	14	in	in	ADP
admet-1465	212	15	the	the	DET
admet-1465	212	16	following	follow	VERB
admet-1465	212	17	lines	line	NOUN
admet-1465	212	18	.	.	PUNCT
admet-1465	213	1	derivative	derivative	ADJ
admet-1465	213	2	spectroscopy	spectroscopy	NOUN
admet-1465	213	3	in	in	ADP
admet-1465	213	4	order	order	NOUN
admet-1465	213	5	to	to	PART
admet-1465	213	6	eliminate	eliminate	VERB
admet-1465	213	7	the	the	DET
admet-1465	213	8	interference	interference	NOUN
admet-1465	213	9	caused	cause	VERB
admet-1465	213	10	by	by	ADP
admet-1465	213	11	excipient	excipient	NOUN
admet-1465	213	12	's	's	PART
admet-1465	213	13	absorbance	absorbance	NOUN
admet-1465	213	14	at	at	ADP
admet-1465	213	15	241	241	NUM
admet-1465	213	16	nm	nm	PROPN
admet-1465	213	17	,	,	PUNCT
admet-1465	213	18	derivative	derivative	ADJ
admet-1465	213	19	spectroscopy	spectroscopy	NOUN
admet-1465	213	20	was	be	AUX
admet-1465	213	21	introduced	introduce	VERB
admet-1465	213	22	.	.	PUNCT
admet-1465	214	1	dex	dex	NOUN
admet-1465	214	2	uv	uv	NOUN
admet-1465	214	3	spectrum	spectrum	NOUN
admet-1465	214	4	is	be	AUX
admet-1465	214	5	characterized	characterize	VERB
admet-1465	214	6	by	by	ADP
admet-1465	214	7	a	a	DET
admet-1465	214	8	local	local	ADJ
admet-1465	214	9	maximum	maximum	NOUN
admet-1465	214	10	of	of	ADP
admet-1465	214	11	absorbance	absorbance	NOUN
admet-1465	214	12	around	around	ADP
admet-1465	214	13	240	240	NUM
admet-1465	214	14	nm	nm	NOUN
admet-1465	214	15	,	,	PUNCT
admet-1465	214	16	while	while	SCONJ
admet-1465	214	17	the	the	DET
admet-1465	214	18	placebo	placebo	NOUN
admet-1465	214	19	spectrum	spectrum	NOUN
admet-1465	214	20	is	be	AUX
admet-1465	214	21	predominantly	predominantly	ADV
admet-1465	214	22	flat	flat	ADJ
admet-1465	214	23	around	around	ADP
admet-1465	214	24	that	that	DET
admet-1465	214	25	wavelength	wavelength	NOUN
admet-1465	214	26	(	(	PUNCT
admet-1465	214	27	figure	figure	NOUN
admet-1465	214	28	9	9	NUM
admet-1465	214	29	)	)	PUNCT
admet-1465	214	30	.	.	PUNCT
admet-1465	215	1	the	the	DET
admet-1465	215	2	first	first	ADJ
admet-1465	215	3	derivative	derivative	ADJ
admet-1465	215	4	curve	curve	NOUN
admet-1465	215	5	of	of	ADP
admet-1465	215	6	the	the	DET
admet-1465	215	7	dex	dex	NOUN
admet-1465	215	8	spectrum	spectrum	NOUN
admet-1465	215	9	should	should	AUX
admet-1465	215	10	therefore	therefore	ADV
admet-1465	215	11	have	have	VERB
admet-1465	215	12	two	two	NUM
admet-1465	215	13	extremes	extreme	NOUN
admet-1465	215	14	at	at	ADP
admet-1465	215	15	its	its	PRON
admet-1465	215	16	peak	peak	NOUN
admet-1465	215	17	inflection	inflection	NOUN
admet-1465	215	18	points	point	NOUN
admet-1465	215	19	,	,	PUNCT
admet-1465	215	20	while	while	SCONJ
admet-1465	215	21	the	the	DET
admet-1465	215	22	placebo	placebo	NOUN
admet-1465	215	23	would	would	AUX
admet-1465	215	24	be	be	AUX
admet-1465	215	25	predominantly	predominantly	ADV
admet-1465	215	26	flat	flat	ADJ
admet-1465	215	27	with	with	ADP
admet-1465	215	28	values	value	NOUN
admet-1465	215	29	around	around	ADP
admet-1465	215	30	zero	zero	NUM
admet-1465	215	31	.	.	PUNCT
admet-1465	215	32	comparing	compare	VERB
admet-1465	215	33	the	the	DET
admet-1465	215	34	first	first	ADJ
admet-1465	215	35	derivative	derivative	ADJ
admet-1465	215	36	values	value	NOUN
admet-1465	215	37	(	(	PUNCT
admet-1465	215	38	at	at	ADP
admet-1465	215	39	the	the	DET
admet-1465	215	40	wavelength	wavelength	NOUN
admet-1465	215	41	corresponding	correspond	VERB
admet-1465	215	42	to	to	ADP
admet-1465	215	43	the	the	DET
admet-1465	215	44	curve	curve	NOUN
admet-1465	215	45	’s	’s	PART
admet-1465	215	46	extreme	extreme	NOUN
admet-1465	215	47	)	)	PUNCT
admet-1465	215	48	of	of	ADP
admet-1465	215	49	standard	standard	ADJ
admet-1465	215	50	solution	solution	NOUN
admet-1465	215	51	spectra	spectra	NOUN
admet-1465	215	52	(	(	PUNCT
admet-1465	215	53	i.e.	i.e.	X
admet-1465	215	54	100	100	NUM
admet-1465	215	55	%	%	NOUN
admet-1465	215	56	dissolved	dissolve	VERB
admet-1465	215	57	dex	dex	NOUN
admet-1465	215	58	)	)	PUNCT
admet-1465	215	59	with	with	ADP
admet-1465	215	60	respective	respective	ADJ
admet-1465	215	61	first	first	ADJ
admet-1465	215	62	derivative	derivative	ADJ
admet-1465	215	63	values	value	NOUN
admet-1465	215	64	of	of	ADP
admet-1465	215	65	samples	sample	NOUN
admet-1465	215	66	spectra	spectra	NOUN
admet-1465	215	67	at	at	ADP
admet-1465	215	68	each	each	DET
admet-1465	215	69	time	time	NOUN
admet-1465	215	70	point	point	NOUN
admet-1465	215	71	,	,	PUNCT
admet-1465	215	72	the	the	DET
admet-1465	215	73	dex	dex	NOUN
admet-1465	215	74	release	release	NOUN
admet-1465	215	75	curve	curve	NOUN
admet-1465	215	76	without	without	ADP
admet-1465	215	77	placebo	placebo	NOUN
admet-1465	215	78	interference	interference	NOUN
admet-1465	215	79	should	should	AUX
admet-1465	215	80	be	be	AUX
admet-1465	215	81	obtained	obtain	VERB
admet-1465	215	82	.	.	PUNCT
admet-1465	216	1	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	216	2	filip	filip	PROPN
admet-1465	216	3	kozlina	kozlina	PROPN
admet-1465	216	4	et	et	PROPN
admet-1465	216	5	al	al	PROPN
admet-1465	216	6	.	.	PROPN
admet-1465	216	7	admet	admet	PROPN
admet-1465	216	8	&	&	CCONJ
admet-1465	216	9	dmpk	dmpk	PROPN
admet-1465	216	10	10(4	10(4	NUM
admet-1465	216	11	)	)	PUNCT
admet-1465	216	12	(	(	PUNCT
admet-1465	216	13	2022	2022	NUM
admet-1465	216	14	)	)	PUNCT
admet-1465	216	15	315	315	NUM
admet-1465	216	16	-	-	SYM
admet-1465	216	17	329	329	NUM
admet-1465	216	18	326	326	NUM
admet-1465	216	19	figure	figure	NOUN
admet-1465	216	20	8	8	NUM
admet-1465	216	21	.	.	PUNCT
admet-1465	216	22	dex	dex	NOUN
admet-1465	216	23	release	release	NOUN
admet-1465	216	24	profile	profile	NOUN
admet-1465	216	25	from	from	ADP
admet-1465	216	26	isopropanol	isopropanol	NOUN
admet-1465	216	27	test	test	NOUN
admet-1465	216	28	solution	solution	NOUN
admet-1465	216	29	(	(	PUNCT
admet-1465	216	30	orange	orange	NOUN
admet-1465	216	31	)	)	PUNCT
admet-1465	216	32	compared	compare	VERB
admet-1465	216	33	to	to	ADP
admet-1465	216	34	absorbance	absorbance	NOUN
admet-1465	216	35	profile	profile	NOUN
admet-1465	216	36	of	of	ADP
admet-1465	216	37	respective	respective	ADJ
admet-1465	216	38	placebo	placebo	NOUN
admet-1465	216	39	solution	solution	NOUN
admet-1465	216	40	(	(	PUNCT
admet-1465	216	41	green	green	NOUN
admet-1465	216	42	)	)	PUNCT
admet-1465	216	43	.	.	PUNCT
admet-1465	217	1	error	error	NOUN
admet-1465	217	2	bars	bar	NOUN
admet-1465	217	3	represent	represent	VERB
admet-1465	217	4	standard	standard	ADJ
admet-1465	217	5	deviation	deviation	NOUN
admet-1465	217	6	,	,	PUNCT
admet-1465	217	7	n=3	n=3	PUNCT
admet-1465	217	8	(	(	PUNCT
admet-1465	217	9	for	for	ADP
admet-1465	217	10	placebo	placebo	NOUN
admet-1465	217	11	)	)	PUNCT
admet-1465	217	12	and	and	CCONJ
admet-1465	217	13	n=6	n=6	NOUN
admet-1465	217	14	(	(	PUNCT
admet-1465	217	15	for	for	ADP
admet-1465	217	16	test	test	NOUN
admet-1465	217	17	solution	solution	NOUN
admet-1465	217	18	)	)	PUNCT
admet-1465	217	19	.	.	PUNCT
admet-1465	218	1	figure	figure	NOUN
admet-1465	218	2	9	9	NUM
admet-1465	218	3	.	.	PUNCT
admet-1465	218	4	comparison	comparison	NOUN
admet-1465	218	5	of	of	ADP
admet-1465	218	6	dex	dex	NOUN
admet-1465	218	7	(	(	PUNCT
admet-1465	218	8	orange	orange	ADJ
admet-1465	218	9	)	)	PUNCT
admet-1465	218	10	and	and	CCONJ
admet-1465	218	11	placebo	placebo	NOUN
admet-1465	218	12	(	(	PUNCT
admet-1465	218	13	green	green	ADJ
admet-1465	218	14	)	)	PUNCT
admet-1465	218	15	uv	uv	NOUN
admet-1465	218	16	spectra	spectra	NOUN
admet-1465	218	17	.	.	PUNCT
admet-1465	219	1	in	in	ADP
admet-1465	219	2	line	line	NOUN
admet-1465	219	3	with	with	ADP
admet-1465	219	4	that	that	PRON
admet-1465	219	5	,	,	PUNCT
admet-1465	219	6	an	an	DET
admet-1465	219	7	additional	additional	ADJ
admet-1465	219	8	ivr	ivr	NOUN
admet-1465	219	9	experiment	experiment	NOUN
admet-1465	219	10	was	be	AUX
admet-1465	219	11	performed	perform	VERB
admet-1465	219	12	with	with	ADP
admet-1465	219	13	the	the	DET
admet-1465	219	14	isopropanol	isopropanol	NOUN
admet-1465	219	15	test	test	NOUN
admet-1465	219	16	solution	solution	NOUN
admet-1465	219	17	,	,	PUNCT
admet-1465	219	18	according	accord	VERB
admet-1465	219	19	to	to	ADP
admet-1465	219	20	the	the	DET
admet-1465	219	21	already	already	ADV
admet-1465	219	22	described	describe	VERB
admet-1465	219	23	procedure	procedure	NOUN
admet-1465	219	24	.	.	PUNCT
admet-1465	220	1	in	in	ADP
admet-1465	220	2	addition	addition	NOUN
admet-1465	220	3	to	to	ADP
admet-1465	220	4	single	single	ADJ
admet-1465	220	5	point	point	NOUN
admet-1465	220	6	readout	readout	NOUN
admet-1465	220	7	at	at	ADP
admet-1465	220	8	241	241	NUM
admet-1465	220	9	nm	nm	NOUN
admet-1465	220	10	,	,	PUNCT
admet-1465	220	11	spectrum	spectrum	NOUN
admet-1465	220	12	scans	scan	NOUN
admet-1465	220	13	from	from	ADP
admet-1465	220	14	200	200	NUM
admet-1465	220	15	to	to	PART
admet-1465	220	16	300	300	NUM
admet-1465	220	17	nm	nm	NOUN
admet-1465	220	18	were	be	AUX
admet-1465	220	19	obtained	obtain	VERB
admet-1465	220	20	for	for	ADP
admet-1465	220	21	standard	standard	ADJ
admet-1465	220	22	solution	solution	NOUN
admet-1465	220	23	and	and	CCONJ
admet-1465	220	24	samples	sample	NOUN
admet-1465	220	25	at	at	ADP
admet-1465	220	26	each	each	DET
admet-1465	220	27	time	time	NOUN
admet-1465	220	28	point	point	NOUN
admet-1465	220	29	in	in	ADP
admet-1465	220	30	5	5	NUM
admet-1465	220	31	vessels	vessel	NOUN
admet-1465	220	32	during	during	ADP
admet-1465	220	33	the	the	DET
admet-1465	220	34	48	48	NUM
admet-1465	220	35	hours	hour	NOUN
admet-1465	220	36	of	of	ADP
admet-1465	220	37	experiment	experiment	NOUN
admet-1465	220	38	duration	duration	NOUN
admet-1465	220	39	.	.	PUNCT
admet-1465	221	1	by	by	ADP
admet-1465	221	2	applying	apply	VERB
admet-1465	221	3	the	the	DET
admet-1465	221	4	first	first	ADJ
admet-1465	221	5	derivative	derivative	NOUN
admet-1465	221	6	on	on	ADP
admet-1465	221	7	spectrum	spectrum	NOUN
admet-1465	221	8	scans	scan	NOUN
admet-1465	221	9	,	,	PUNCT
admet-1465	221	10	252	252	NUM
admet-1465	221	11	nm	nm	NOUN
admet-1465	221	12	was	be	AUX
admet-1465	221	13	identified	identify	VERB
admet-1465	221	14	as	as	ADP
admet-1465	221	15	the	the	DET
admet-1465	221	16	extreme	extreme	ADJ
admet-1465	221	17	value	value	NOUN
admet-1465	221	18	for	for	ADP
admet-1465	221	19	obtained	obtain	VERB
admet-1465	221	20	curves	curve	NOUN
admet-1465	221	21	.	.	PUNCT
admet-1465	222	1	the	the	DET
admet-1465	222	2	samples	sample	NOUN
admet-1465	222	3	to	to	PART
admet-1465	222	4	standards	standard	VERB
admet-1465	222	5	ratio	ratio	NOUN
admet-1465	222	6	of	of	ADP
admet-1465	222	7	first	first	ADJ
admet-1465	222	8	derivative	derivative	ADJ
admet-1465	222	9	values	value	NOUN
admet-1465	222	10	at	at	ADP
admet-1465	222	11	252	252	NUM
admet-1465	222	12	nm	nm	NOUN
admet-1465	222	13	resulted	result	VERB
admet-1465	222	14	in	in	ADP
admet-1465	222	15	the	the	DET
admet-1465	222	16	dex	dex	NOUN
admet-1465	222	17	release	release	NOUN
admet-1465	222	18	profile	profile	NOUN
admet-1465	222	19	corrected	correct	VERB
admet-1465	222	20	to	to	ADP
admet-1465	222	21	excipients	excipient	NOUN
admet-1465	222	22	interference	interference	NOUN
admet-1465	222	23	.	.	PUNCT
admet-1465	223	1	the	the	DET
admet-1465	223	2	plateau	plateau	NOUN
admet-1465	223	3	with	with	ADP
admet-1465	223	4	over	over	ADP
admet-1465	223	5	90	90	NUM
admet-1465	223	6	%	%	NOUN
admet-1465	223	7	released	release	VERB
admet-1465	223	8	dex	dex	NOUN
admet-1465	223	9	was	be	AUX
admet-1465	223	10	obtained	obtain	VERB
admet-1465	223	11	at	at	ADP
admet-1465	223	12	two	two	NUM
admet-1465	223	13	finishing	finish	VERB
admet-1465	223	14	time	time	NOUN
admet-1465	223	15	points	point	NOUN
admet-1465	223	16	.	.	PUNCT
admet-1465	224	1	when	when	SCONJ
admet-1465	224	2	comparing	compare	VERB
admet-1465	224	3	the	the	DET
admet-1465	224	4	corrected	correct	VERB
admet-1465	224	5	average	average	ADJ
admet-1465	224	6	release	release	NOUN
admet-1465	224	7	profile	profile	NOUN
admet-1465	224	8	to	to	ADP
admet-1465	224	9	the	the	DET
admet-1465	224	10	one	one	NOUN
admet-1465	224	11	obtained	obtain	VERB
admet-1465	224	12	by	by	ADP
admet-1465	224	13	fiber	fiber	NOUN
admet-1465	224	14	optic	optic	PROPN
admet-1465	224	15	detection	detection	NOUN
admet-1465	224	16	,	,	PUNCT
admet-1465	224	17	reasonable	reasonable	ADJ
admet-1465	224	18	matching	matching	NOUN
admet-1465	224	19	was	be	AUX
admet-1465	224	20	obtained	obtain	VERB
admet-1465	224	21	up	up	ADP
admet-1465	224	22	to	to	PART
admet-1465	224	23	36	36	NUM
admet-1465	224	24	-	-	PUNCT
admet-1465	224	25	hour	hour	NOUN
admet-1465	224	26	time	time	NOUN
admet-1465	224	27	point	point	NOUN
admet-1465	224	28	(	(	PUNCT
admet-1465	224	29	figure	figure	NOUN
admet-1465	224	30	10	10	NUM
admet-1465	224	31	)	)	PUNCT
admet-1465	224	32	.	.	PUNCT
admet-1465	225	1	admet	admet	PROPN
admet-1465	225	2	&	&	CCONJ
admet-1465	225	3	dmpk	dmpk	PROPN
admet-1465	225	4	10(4	10(4	NUM
admet-1465	225	5	)	)	PUNCT
admet-1465	225	6	(	(	PUNCT
admet-1465	225	7	2022	2022	NUM
admet-1465	225	8	)	)	PUNCT
admet-1465	225	9	315	315	NUM
admet-1465	225	10	-	-	SYM
admet-1465	225	11	329	329	NUM
admet-1465	225	12	dexamethasone	dexamethasone	NOUN
admet-1465	225	13	release	release	NOUN
admet-1465	225	14	from	from	ADP
admet-1465	225	15	the	the	DET
admet-1465	225	16	oil	oil	NOUN
admet-1465	225	17	solutions	solution	NOUN
admet-1465	225	18	doi	doi	NOUN
admet-1465	225	19	:	:	PUNCT
admet-1465	225	20	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	NOUN
admet-1465	225	21	327	327	NUM
admet-1465	225	22	although	although	SCONJ
admet-1465	225	23	the	the	DET
admet-1465	225	24	second	second	ADJ
admet-1465	225	25	derivative	derivative	NOUN
admet-1465	225	26	may	may	AUX
admet-1465	225	27	be	be	AUX
admet-1465	225	28	more	more	ADV
admet-1465	225	29	suitable	suitable	ADJ
admet-1465	225	30	for	for	ADP
admet-1465	225	31	extracting	extract	VERB
admet-1465	225	32	drug	drug	NOUN
admet-1465	225	33	-	-	PUNCT
admet-1465	225	34	specific	specific	ADJ
admet-1465	225	35	information	information	NOUN
admet-1465	225	36	,	,	PUNCT
admet-1465	225	37	in	in	ADP
admet-1465	225	38	this	this	DET
admet-1465	225	39	case	case	NOUN
admet-1465	225	40	,	,	PUNCT
admet-1465	225	41	more	more	ADV
admet-1465	225	42	reliable	reliable	ADJ
admet-1465	225	43	results	result	NOUN
admet-1465	225	44	were	be	AUX
admet-1465	225	45	obtained	obtain	VERB
admet-1465	225	46	with	with	ADP
admet-1465	225	47	the	the	DET
admet-1465	225	48	first	first	ADJ
admet-1465	225	49	derivative	derivative	NOUN
admet-1465	225	50	.	.	PUNCT
admet-1465	226	1	since	since	SCONJ
admet-1465	226	2	dexamethasone	dexamethasone	NOUN
admet-1465	226	3	spectrum	spectrum	NOUN
admet-1465	226	4	has	have	VERB
admet-1465	226	5	a	a	DET
admet-1465	226	6	local	local	ADJ
admet-1465	226	7	maximum	maximum	NOUN
admet-1465	226	8	around	around	ADP
admet-1465	226	9	240	240	NUM
admet-1465	226	10	nm	nm	NOUN
admet-1465	226	11	,	,	PUNCT
admet-1465	226	12	while	while	SCONJ
admet-1465	226	13	placebo	placebo	NOUN
admet-1465	226	14	spectrum	spectrum	NOUN
admet-1465	226	15	is	be	AUX
admet-1465	226	16	predominantly	predominantly	ADV
admet-1465	226	17	flat	flat	ADJ
admet-1465	226	18	in	in	ADP
admet-1465	226	19	a	a	DET
admet-1465	226	20	wide	wide	ADJ
admet-1465	226	21	range	range	NOUN
admet-1465	226	22	around	around	ADP
admet-1465	226	23	that	that	DET
admet-1465	226	24	wavelength	wavelength	NOUN
admet-1465	226	25	,	,	PUNCT
admet-1465	226	26	the	the	DET
admet-1465	226	27	spectra	spectra	PROPN
admet-1465	226	28	first	first	ADJ
admet-1465	226	29	derivative	derivative	NOUN
admet-1465	226	30	resulted	result	VERB
admet-1465	226	31	with	with	ADP
admet-1465	226	32	local	local	ADJ
admet-1465	226	33	extremes	extreme	NOUN
admet-1465	226	34	at	at	ADP
admet-1465	226	35	inflection	inflection	NOUN
admet-1465	226	36	points	point	NOUN
admet-1465	226	37	for	for	ADP
admet-1465	226	38	dexamethasone	dexamethasone	NOUN
admet-1465	226	39	while	while	SCONJ
admet-1465	226	40	for	for	ADP
admet-1465	226	41	placebo	placebo	NOUN
admet-1465	226	42	it	it	PRON
admet-1465	226	43	was	be	AUX
admet-1465	226	44	flat	flat	ADJ
admet-1465	226	45	with	with	ADP
admet-1465	226	46	values	value	NOUN
admet-1465	226	47	around	around	ADP
admet-1465	226	48	zero	zero	NUM
admet-1465	226	49	.	.	PUNCT
admet-1465	227	1	the	the	DET
admet-1465	227	2	local	local	ADJ
admet-1465	227	3	extreme	extreme	NOUN
admet-1465	227	4	at	at	ADP
admet-1465	227	5	252	252	NUM
admet-1465	227	6	nm	nm	NOUN
admet-1465	227	7	was	be	AUX
admet-1465	227	8	chosen	choose	VERB
admet-1465	227	9	for	for	ADP
admet-1465	227	10	calculating	calculate	VERB
admet-1465	227	11	dexamethasone	dexamethasone	NOUN
admet-1465	227	12	release	release	NOUN
admet-1465	227	13	percentages	percentage	NOUN
admet-1465	227	14	by	by	ADP
admet-1465	227	15	comparing	compare	VERB
admet-1465	227	16	the	the	DET
admet-1465	227	17	first	first	ADJ
admet-1465	227	18	derivative	derivative	ADJ
admet-1465	227	19	values	value	NOUN
admet-1465	227	20	of	of	ADP
admet-1465	227	21	samples	sample	NOUN
admet-1465	227	22	in	in	ADP
admet-1465	227	23	each	each	DET
admet-1465	227	24	vessel	vessel	NOUN
admet-1465	227	25	with	with	ADP
admet-1465	227	26	the	the	DET
admet-1465	227	27	respective	respective	ADJ
admet-1465	227	28	standard	standard	ADJ
admet-1465	227	29	first	first	ADJ
admet-1465	227	30	derivative	derivative	ADJ
admet-1465	227	31	values	value	NOUN
admet-1465	227	32	.	.	PUNCT
admet-1465	228	1	although	although	SCONJ
admet-1465	228	2	a	a	DET
admet-1465	228	3	relatively	relatively	ADV
admet-1465	228	4	narrow	narrow	ADJ
admet-1465	228	5	range	range	NOUN
admet-1465	228	6	window	window	NOUN
admet-1465	228	7	was	be	AUX
admet-1465	228	8	obtained	obtain	VERB
admet-1465	228	9	for	for	ADP
admet-1465	228	10	the	the	DET
admet-1465	228	11	absolute	absolute	ADJ
admet-1465	228	12	values	value	NOUN
admet-1465	228	13	of	of	ADP
admet-1465	228	14	first	first	ADJ
admet-1465	228	15	derivative	derivative	ADJ
admet-1465	228	16	curves	curve	NOUN
admet-1465	228	17	at	at	ADP
admet-1465	228	18	252	252	NUM
admet-1465	228	19	nm	nm	NOUN
admet-1465	228	20	,	,	PUNCT
admet-1465	228	21	the	the	DET
admet-1465	228	22	resulting	result	VERB
admet-1465	228	23	release	release	NOUN
admet-1465	228	24	curves	curve	NOUN
admet-1465	228	25	were	be	AUX
admet-1465	228	26	similar	similar	ADJ
admet-1465	228	27	when	when	SCONJ
admet-1465	228	28	comparing	compare	VERB
admet-1465	228	29	different	different	ADJ
admet-1465	228	30	vessels	vessel	NOUN
admet-1465	228	31	and	and	CCONJ
admet-1465	228	32	reasonable	reasonable	ADJ
admet-1465	228	33	matching	matching	NOUN
admet-1465	228	34	was	be	AUX
admet-1465	228	35	obtained	obtain	VERB
admet-1465	228	36	between	between	ADP
admet-1465	228	37	the	the	DET
admet-1465	228	38	average	average	ADJ
admet-1465	228	39	release	release	NOUN
admet-1465	228	40	curve	curve	NOUN
admet-1465	228	41	and	and	CCONJ
admet-1465	228	42	the	the	DET
admet-1465	228	43	one	one	NOUN
admet-1465	228	44	with	with	ADP
admet-1465	228	45	no	no	DET
admet-1465	228	46	correction	correction	NOUN
admet-1465	228	47	.	.	PUNCT
admet-1465	229	1	moreover	moreover	ADV
admet-1465	229	2	,	,	PUNCT
admet-1465	229	3	the	the	DET
admet-1465	229	4	interference	interference	NOUN
admet-1465	229	5	from	from	ADP
admet-1465	229	6	excipients	excipient	NOUN
admet-1465	229	7	at	at	ADP
admet-1465	229	8	later	later	ADJ
admet-1465	229	9	time	time	NOUN
admet-1465	229	10	points	point	NOUN
admet-1465	229	11	was	be	AUX
admet-1465	229	12	eliminated	eliminate	VERB
admet-1465	229	13	with	with	ADP
admet-1465	229	14	the	the	DET
admet-1465	229	15	first	first	ADJ
admet-1465	229	16	derivative	derivative	NOUN
admet-1465	229	17	.	.	PUNCT
admet-1465	230	1	the	the	DET
admet-1465	230	2	second	second	ADJ
admet-1465	230	3	derivative	derivative	ADJ
admet-1465	230	4	curves	curve	NOUN
admet-1465	230	5	were	be	AUX
admet-1465	230	6	also	also	ADV
admet-1465	230	7	calculated	calculate	VERB
admet-1465	230	8	by	by	ADP
admet-1465	230	9	using	use	VERB
admet-1465	230	10	the	the	DET
admet-1465	230	11	same	same	ADJ
admet-1465	230	12	data	datum	NOUN
admet-1465	230	13	.	.	PUNCT
admet-1465	231	1	since	since	SCONJ
admet-1465	231	2	the	the	DET
admet-1465	231	3	window	window	NOUN
admet-1465	231	4	range	range	NOUN
admet-1465	231	5	is	be	AUX
admet-1465	231	6	narrowed	narrow	VERB
admet-1465	231	7	with	with	ADP
admet-1465	231	8	every	every	DET
admet-1465	231	9	consecutive	consecutive	ADJ
admet-1465	231	10	derivation	derivation	NOUN
admet-1465	231	11	step	step	NOUN
admet-1465	231	12	,	,	PUNCT
admet-1465	231	13	the	the	DET
admet-1465	231	14	second	second	ADJ
admet-1465	231	15	derivative	derivative	NOUN
admet-1465	231	16	resulted	result	VERB
admet-1465	231	17	in	in	ADP
admet-1465	231	18	a	a	DET
admet-1465	231	19	range	range	NOUN
admet-1465	231	20	that	that	PRON
admet-1465	231	21	was	be	AUX
admet-1465	231	22	too	too	ADV
admet-1465	231	23	narrow	narrow	ADJ
admet-1465	231	24	for	for	ADP
admet-1465	231	25	reliable	reliable	ADJ
admet-1465	231	26	calculation	calculation	NOUN
admet-1465	231	27	.	.	PUNCT
admet-1465	232	1	therefore	therefore	ADV
admet-1465	232	2	,	,	PUNCT
admet-1465	232	3	the	the	DET
admet-1465	232	4	results	result	NOUN
admet-1465	232	5	obtained	obtain	VERB
admet-1465	232	6	from	from	ADP
admet-1465	232	7	the	the	DET
admet-1465	232	8	first	first	ADJ
admet-1465	232	9	derivative	derivative	ADJ
admet-1465	232	10	curves	curve	NOUN
admet-1465	232	11	were	be	AUX
admet-1465	232	12	used	use	VERB
admet-1465	232	13	for	for	ADP
admet-1465	232	14	interference	interference	NOUN
admet-1465	232	15	elimination	elimination	NOUN
admet-1465	232	16	.	.	PUNCT
admet-1465	233	1	figure	figure	NOUN
admet-1465	233	2	10	10	NUM
admet-1465	233	3	.	.	PUNCT
admet-1465	234	1	dex	dex	NOUN
admet-1465	234	2	average	average	ADJ
admet-1465	234	3	release	release	NOUN
admet-1465	234	4	profiles	profile	NOUN
admet-1465	234	5	obtained	obtain	VERB
admet-1465	234	6	by	by	ADP
admet-1465	234	7	fiber	fiber	NOUN
admet-1465	234	8	optic	optic	NOUN
admet-1465	234	9	detection	detection	NOUN
admet-1465	234	10	at	at	ADP
admet-1465	234	11	241	241	NUM
admet-1465	234	12	nm	nm	ADJ
admet-1465	234	13	(	(	PUNCT
admet-1465	234	14	orange	orange	ADJ
admet-1465	234	15	)	)	PUNCT
admet-1465	234	16	and	and	CCONJ
admet-1465	234	17	corrected	correct	VERB
admet-1465	234	18	to	to	ADP
admet-1465	234	19	excipients	excipient	NOUN
admet-1465	234	20	interference	interference	NOUN
admet-1465	234	21	by	by	ADP
admet-1465	234	22	applying	apply	VERB
admet-1465	234	23	the	the	DET
admet-1465	234	24	first	first	ADJ
admet-1465	234	25	derivative	derivative	NOUN
admet-1465	234	26	of	of	ADP
admet-1465	234	27	obtained	obtain	VERB
admet-1465	234	28	spectra	spectra	NOUN
admet-1465	234	29	(	(	PUNCT
admet-1465	234	30	dark	dark	ADJ
admet-1465	234	31	blue	blue	NOUN
admet-1465	234	32	)	)	PUNCT
admet-1465	234	33	.	.	PUNCT
admet-1465	235	1	error	error	NOUN
admet-1465	235	2	bars	bar	NOUN
admet-1465	235	3	represent	represent	VERB
admet-1465	235	4	standard	standard	ADJ
admet-1465	235	5	deviation	deviation	NOUN
admet-1465	235	6	,	,	PUNCT
admet-1465	235	7	n=5	n=5	PROPN
admet-1465	235	8	.	.	PUNCT
admet-1465	236	1	conclusions	conclusion	NOUN
admet-1465	236	2	the	the	DET
admet-1465	236	3	lack	lack	NOUN
admet-1465	236	4	of	of	ADP
admet-1465	236	5	a	a	DET
admet-1465	236	6	standardized	standardized	ADJ
admet-1465	236	7	ivr	ivr	NOUN
admet-1465	236	8	method	method	NOUN
admet-1465	236	9	for	for	ADP
admet-1465	236	10	almost	almost	ADV
admet-1465	236	11	all	all	PRON
admet-1465	236	12	types	type	NOUN
admet-1465	236	13	of	of	ADP
admet-1465	236	14	parenteral	parenteral	ADJ
admet-1465	236	15	drug	drug	NOUN
admet-1465	236	16	products	product	NOUN
admet-1465	236	17	,	,	PUNCT
admet-1465	236	18	including	include	VERB
admet-1465	236	19	oil	oil	NOUN
admet-1465	236	20	parenteral	parenteral	ADJ
admet-1465	236	21	solutions	solution	NOUN
admet-1465	236	22	,	,	PUNCT
admet-1465	236	23	motivated	motivate	VERB
admet-1465	236	24	us	we	PRON
admet-1465	236	25	to	to	PART
admet-1465	236	26	develop	develop	VERB
admet-1465	236	27	one	one	NUM
admet-1465	236	28	such	such	ADJ
admet-1465	236	29	method	method	NOUN
admet-1465	236	30	using	use	VERB
admet-1465	236	31	a	a	DET
admet-1465	236	32	routinely	routinely	ADV
admet-1465	236	33	used	use	VERB
admet-1465	236	34	usp	usp	PROPN
admet-1465	236	35	ii	ii	PROPN
admet-1465	236	36	apparatus	apparatus	NOUN
admet-1465	236	37	coupled	couple	VERB
admet-1465	236	38	to	to	ADP
admet-1465	236	39	a	a	DET
admet-1465	236	40	fiber	fiber	NOUN
admet-1465	236	41	optic	optic	NOUN
admet-1465	236	42	uv	uv	NOUN
admet-1465	236	43	-	-	PUNCT
admet-1465	236	44	vis	vis	X
admet-1465	236	45	spectrometer	spectrometer	NOUN
admet-1465	236	46	.	.	PUNCT
admet-1465	237	1	dex	dex	PROPN
admet-1465	237	2	was	be	AUX
admet-1465	237	3	used	use	VERB
admet-1465	237	4	as	as	ADP
admet-1465	237	5	a	a	DET
admet-1465	237	6	model	model	NOUN
admet-1465	237	7	drug	drug	NOUN
admet-1465	237	8	.	.	PUNCT
admet-1465	238	1	test	test	NOUN
admet-1465	238	2	solutions	solution	NOUN
admet-1465	238	3	containing	contain	VERB
admet-1465	238	4	castor	castor	NOUN
admet-1465	238	5	oil	oil	NOUN
admet-1465	238	6	as	as	ADP
admet-1465	238	7	a	a	DET
admet-1465	238	8	solvent	solvent	NOUN
admet-1465	238	9	with	with	ADP
admet-1465	238	10	the	the	DET
admet-1465	238	11	addition	addition	NOUN
admet-1465	238	12	of	of	ADP
admet-1465	238	13	20	20	NUM
admet-1465	238	14	%	%	NOUN
admet-1465	238	15	(	(	PUNCT
admet-1465	238	16	v	v	NOUN
admet-1465	238	17	/	/	SYM
admet-1465	238	18	v	v	NOUN
admet-1465	238	19	)	)	PUNCT
admet-1465	238	20	isopropanol	isopropanol	NOUN
admet-1465	238	21	or	or	CCONJ
admet-1465	238	22	capryol	capryol	NOUN
admet-1465	238	23	®	®	NOUN
admet-1465	238	24	90	90	NUM
admet-1465	238	25	as	as	SCONJ
admet-1465	238	26	a	a	DET
admet-1465	238	27	cosolvent	cosolvent	NOUN
admet-1465	238	28	were	be	AUX
admet-1465	238	29	selected	select	VERB
admet-1465	238	30	based	base	VERB
admet-1465	238	31	on	on	ADP
admet-1465	238	32	the	the	DET
admet-1465	238	33	results	result	NOUN
admet-1465	238	34	of	of	ADP
admet-1465	238	35	solubility	solubility	NOUN
admet-1465	238	36	testing	testing	NOUN
admet-1465	238	37	with	with	ADP
admet-1465	238	38	several	several	ADJ
admet-1465	238	39	vegetable	vegetable	ADJ
admet-1465	238	40	oils	oil	NOUN
admet-1465	238	41	,	,	PUNCT
admet-1465	238	42	as	as	ADV
admet-1465	238	43	well	well	ADV
admet-1465	238	44	as	as	ADP
admet-1465	238	45	a	a	DET
admet-1465	238	46	partitioning	partitioning	ADJ
admet-1465	238	47	study	study	NOUN
admet-1465	238	48	.	.	PUNCT
admet-1465	239	1	the	the	DET
admet-1465	239	2	solubility	solubility	NOUN
admet-1465	239	3	of	of	ADP
admet-1465	239	4	dex	dex	NOUN
admet-1465	239	5	was	be	AUX
admet-1465	239	6	much	much	ADV
admet-1465	239	7	higher	high	ADJ
admet-1465	239	8	in	in	ADP
admet-1465	239	9	castor	castor	NOUN
admet-1465	239	10	oil	oil	NOUN
admet-1465	239	11	than	than	ADP
admet-1465	239	12	in	in	ADP
admet-1465	239	13	other	other	ADJ
admet-1465	239	14	tested	test	VERB
admet-1465	239	15	vegetable	vegetable	NOUN
admet-1465	239	16	oils	oil	NOUN
admet-1465	239	17	.	.	PUNCT
admet-1465	240	1	both	both	PRON
admet-1465	240	2	isopropanol	isopropanol	NOUN
admet-1465	240	3	and	and	CCONJ
admet-1465	240	4	capryol	capryol	NOUN
admet-1465	240	5	®	®	NOUN
admet-1465	240	6	90	90	NUM
admet-1465	240	7	proved	prove	VERB
admet-1465	240	8	to	to	PART
admet-1465	240	9	be	be	AUX
admet-1465	240	10	efficient	efficient	ADJ
admet-1465	240	11	cosolvents	cosolvent	NOUN
admet-1465	240	12	,	,	PUNCT
admet-1465	240	13	helping	help	VERB
admet-1465	240	14	to	to	PART
admet-1465	240	15	achieve	achieve	VERB
admet-1465	240	16	higher	high	ADJ
admet-1465	240	17	concentrations	concentration	NOUN
admet-1465	240	18	of	of	ADP
admet-1465	240	19	dex	dex	NOUN
admet-1465	240	20	in	in	ADP
admet-1465	240	21	test	test	NOUN
admet-1465	240	22	solutions	solution	NOUN
admet-1465	240	23	(	(	PUNCT
admet-1465	240	24	2	2	NUM
admet-1465	240	25	mg	mg	NUM
admet-1465	240	26	/	/	SYM
admet-1465	240	27	ml	ml	NOUN
admet-1465	240	28	and	and	CCONJ
admet-1465	240	29	1	1	NUM
admet-1465	240	30	mg	mg	NUM
admet-1465	240	31	/	/	SYM
admet-1465	240	32	ml	ml	NOUN
admet-1465	240	33	for	for	ADP
admet-1465	240	34	isopropanol	isopropanol	NOUN
admet-1465	240	35	and	and	CCONJ
admet-1465	240	36	capryol	capryol	NOUN
admet-1465	240	37	®	®	NOUN
admet-1465	240	38	90	90	NUM
admet-1465	240	39	,	,	PUNCT
admet-1465	240	40	respectively	respectively	ADV
admet-1465	240	41	)	)	PUNCT
admet-1465	240	42	.	.	PUNCT
admet-1465	241	1	partitioning	partition	VERB
admet-1465	241	2	of	of	ADP
admet-1465	241	3	dex	dex	NOUN
admet-1465	241	4	in	in	ADP
admet-1465	241	5	these	these	PRON
admet-1465	241	6	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	241	7	filip	filip	PROPN
admet-1465	241	8	kozlina	kozlina	PROPN
admet-1465	241	9	et	et	PROPN
admet-1465	241	10	al	al	PROPN
admet-1465	241	11	.	.	PROPN
admet-1465	241	12	admet	admet	PROPN
admet-1465	241	13	&	&	CCONJ
admet-1465	241	14	dmpk	dmpk	PROPN
admet-1465	241	15	10(4	10(4	NUM
admet-1465	241	16	)	)	PUNCT
admet-1465	241	17	(	(	PUNCT
admet-1465	241	18	2022	2022	NUM
admet-1465	241	19	)	)	PUNCT
admet-1465	241	20	315	315	NUM
admet-1465	241	21	-	-	SYM
admet-1465	241	22	329	329	NUM
admet-1465	241	23	328	328	NUM
admet-1465	241	24	test	test	NOUN
admet-1465	241	25	solutions	solution	NOUN
admet-1465	241	26	was	be	AUX
admet-1465	241	27	adequate	adequate	ADJ
admet-1465	241	28	to	to	PART
admet-1465	241	29	ensure	ensure	VERB
admet-1465	241	30	the	the	DET
admet-1465	241	31	prolonged	prolonged	ADJ
admet-1465	241	32	release	release	NOUN
admet-1465	241	33	of	of	ADP
admet-1465	241	34	dex	dex	NOUN
admet-1465	241	35	,	,	PUNCT
admet-1465	241	36	and	and	CCONJ
admet-1465	241	37	therefore	therefore	ADV
admet-1465	241	38	they	they	PRON
admet-1465	241	39	were	be	AUX
admet-1465	241	40	chosen	choose	VERB
admet-1465	241	41	as	as	ADP
admet-1465	241	42	model	model	NOUN
admet-1465	241	43	formulations	formulation	NOUN
admet-1465	241	44	.	.	PUNCT
admet-1465	242	1	the	the	DET
admet-1465	242	2	developed	develop	VERB
admet-1465	242	3	dialysis	dialysis	NOUN
admet-1465	242	4	method	method	NOUN
admet-1465	242	5	has	have	AUX
admet-1465	242	6	proven	prove	VERB
admet-1465	242	7	to	to	PART
admet-1465	242	8	be	be	AUX
admet-1465	242	9	sensitive	sensitive	ADJ
admet-1465	242	10	to	to	ADP
admet-1465	242	11	temperature	temperature	NOUN
admet-1465	242	12	and	and	CCONJ
admet-1465	242	13	moderately	moderately	ADV
admet-1465	242	14	to	to	ADP
admet-1465	242	15	stirring	stir	VERB
admet-1465	242	16	rate	rate	NOUN
admet-1465	242	17	and	and	CCONJ
admet-1465	242	18	has	have	AUX
admet-1465	242	19	satisfying	satisfy	VERB
admet-1465	242	20	reproducibility	reproducibility	NOUN
admet-1465	242	21	with	with	ADP
admet-1465	242	22	respect	respect	NOUN
admet-1465	242	23	to	to	ADP
admet-1465	242	24	usp	usp	NOUN
admet-1465	242	25	standards	standard	NOUN
admet-1465	242	26	for	for	ADP
admet-1465	242	27	ivr	ivr	NOUN
admet-1465	242	28	methods	method	NOUN
admet-1465	242	29	.	.	PUNCT
admet-1465	243	1	furthermore	furthermore	ADV
admet-1465	243	2	,	,	PUNCT
admet-1465	243	3	an	an	DET
admet-1465	243	4	automated	automate	VERB
admet-1465	243	5	system	system	NOUN
admet-1465	243	6	enables	enable	VERB
admet-1465	243	7	online	online	ADJ
admet-1465	243	8	detection	detection	NOUN
admet-1465	243	9	and	and	CCONJ
admet-1465	243	10	monitoring	monitoring	NOUN
admet-1465	243	11	of	of	ADP
admet-1465	243	12	the	the	DET
admet-1465	243	13	release	release	NOUN
admet-1465	243	14	through	through	ADP
admet-1465	243	15	the	the	DET
admet-1465	243	16	fiber	fiber	NOUN
admet-1465	243	17	optic	optic	NOUN
admet-1465	243	18	probes	probe	NOUN
admet-1465	243	19	immersed	immerse	VERB
admet-1465	243	20	in	in	ADP
admet-1465	243	21	the	the	DET
admet-1465	243	22	dissolution	dissolution	NOUN
admet-1465	243	23	medium	medium	NOUN
admet-1465	243	24	for	for	ADP
admet-1465	243	25	the	the	DET
admet-1465	243	26	whole	whole	ADJ
admet-1465	243	27	duration	duration	NOUN
admet-1465	243	28	of	of	ADP
admet-1465	243	29	the	the	DET
admet-1465	243	30	experiment	experiment	NOUN
admet-1465	243	31	without	without	ADP
admet-1465	243	32	the	the	DET
admet-1465	243	33	need	need	NOUN
admet-1465	243	34	for	for	ADP
admet-1465	243	35	additional	additional	ADJ
admet-1465	243	36	sampling	sampling	NOUN
admet-1465	243	37	and	and	CCONJ
admet-1465	243	38	analysis	analysis	NOUN
admet-1465	243	39	.	.	PUNCT
admet-1465	244	1	packing	pack	VERB
admet-1465	244	2	the	the	DET
admet-1465	244	3	samples	sample	NOUN
admet-1465	244	4	in	in	ADP
admet-1465	244	5	dialysis	dialysis	NOUN
admet-1465	244	6	bags	bag	NOUN
admet-1465	244	7	helped	help	VERB
admet-1465	244	8	avoid	avoid	VERB
admet-1465	244	9	floating	float	VERB
admet-1465	244	10	and	and	CCONJ
admet-1465	244	11	sticking	stick	VERB
admet-1465	244	12	the	the	DET
admet-1465	244	13	oil	oil	NOUN
admet-1465	244	14	solution	solution	NOUN
admet-1465	244	15	to	to	ADP
admet-1465	244	16	the	the	DET
admet-1465	244	17	apparatus	apparatus	NOUN
admet-1465	244	18	,	,	PUNCT
admet-1465	244	19	minimized	minimize	VERB
admet-1465	244	20	the	the	DET
admet-1465	244	21	chance	chance	NOUN
admet-1465	244	22	of	of	ADP
admet-1465	244	23	interference	interference	NOUN
admet-1465	244	24	with	with	ADP
admet-1465	244	25	optic	optic	ADJ
admet-1465	244	26	probe	probe	NOUN
admet-1465	244	27	reading	reading	NOUN
admet-1465	244	28	and	and	CCONJ
admet-1465	244	29	acted	act	VERB
admet-1465	244	30	as	as	ADP
admet-1465	244	31	a	a	DET
admet-1465	244	32	“	"	PUNCT
admet-1465	244	33	sample	sample	NOUN
admet-1465	244	34	holder	holder	NOUN
admet-1465	244	35	”	"	PUNCT
admet-1465	244	36	mimicking	mimic	VERB
admet-1465	244	37	in	in	ADP
admet-1465	244	38	vivo	vivo	ADJ
admet-1465	244	39	distribution	distribution	NOUN
admet-1465	244	40	of	of	ADP
admet-1465	244	41	the	the	DET
admet-1465	244	42	oil	oil	NOUN
admet-1465	244	43	depot	depot	NOUN
admet-1465	244	44	.	.	PUNCT
admet-1465	245	1	however	however	ADV
admet-1465	245	2	,	,	PUNCT
admet-1465	245	3	most	most	ADV
admet-1465	245	4	probably	probably	ADV
admet-1465	245	5	due	due	ADJ
admet-1465	245	6	to	to	ADP
admet-1465	245	7	diffusion	diffusion	NOUN
admet-1465	245	8	of	of	ADP
admet-1465	245	9	excipients	excipient	NOUN
admet-1465	245	10	through	through	ADP
admet-1465	245	11	the	the	DET
admet-1465	245	12	membrane	membrane	NOUN
admet-1465	245	13	,	,	PUNCT
admet-1465	245	14	significant	significant	ADJ
admet-1465	245	15	interference	interference	NOUN
admet-1465	245	16	in	in	ADP
admet-1465	245	17	reading	reading	NOUN
admet-1465	245	18	was	be	AUX
admet-1465	245	19	observed	observe	VERB
admet-1465	245	20	in	in	ADP
admet-1465	245	21	later	later	ADJ
admet-1465	245	22	time	time	NOUN
admet-1465	245	23	points	point	NOUN
admet-1465	245	24	,	,	PUNCT
admet-1465	245	25	more	more	ADV
admet-1465	245	26	pronounced	pronounced	ADJ
admet-1465	245	27	with	with	ADP
admet-1465	245	28	a	a	DET
admet-1465	245	29	formulation	formulation	NOUN
admet-1465	245	30	containing	contain	VERB
admet-1465	245	31	capryol	capryol	PROPN
admet-1465	245	32	®	®	NOUN
admet-1465	245	33	90	90	NUM
admet-1465	245	34	.	.	PUNCT
admet-1465	246	1	excipients	excipient	NOUN
admet-1465	246	2	interference	interference	NOUN
admet-1465	246	3	was	be	AUX
admet-1465	246	4	successfully	successfully	ADV
admet-1465	246	5	eliminated	eliminate	VERB
admet-1465	246	6	by	by	ADP
admet-1465	246	7	introducing	introduce	VERB
admet-1465	246	8	derivative	derivative	ADJ
admet-1465	246	9	spectroscopy	spectroscopy	NOUN
admet-1465	246	10	.	.	PUNCT
admet-1465	247	1	both	both	DET
admet-1465	247	2	test	test	NOUN
admet-1465	247	3	solutions	solution	NOUN
admet-1465	247	4	showed	show	VERB
admet-1465	247	5	similar	similar	ADJ
admet-1465	247	6	,	,	PUNCT
admet-1465	247	7	prolonged	prolonged	ADJ
admet-1465	247	8	release	release	NOUN
admet-1465	247	9	profiles	profile	NOUN
admet-1465	247	10	.	.	PUNCT
admet-1465	248	1	taking	take	VERB
admet-1465	248	2	into	into	ADP
admet-1465	248	3	account	account	NOUN
admet-1465	248	4	that	that	SCONJ
admet-1465	248	5	the	the	DET
admet-1465	248	6	concentration	concentration	NOUN
admet-1465	248	7	of	of	ADP
admet-1465	248	8	dex	dex	NOUN
admet-1465	248	9	achieved	achieve	VERB
admet-1465	248	10	in	in	ADP
admet-1465	248	11	the	the	DET
admet-1465	248	12	solution	solution	NOUN
admet-1465	248	13	containing	contain	VERB
admet-1465	248	14	isopropanol	isopropanol	NOUN
admet-1465	248	15	is	be	AUX
admet-1465	248	16	twice	twice	DET
admet-1465	248	17	the	the	DET
admet-1465	248	18	one	one	NOUN
admet-1465	248	19	achieved	achieve	VERB
admet-1465	248	20	with	with	ADP
admet-1465	248	21	capryol	capryol	PROPN
admet-1465	248	22	®	®	NOUN
admet-1465	248	23	90	90	NUM
admet-1465	248	24	,	,	PUNCT
admet-1465	248	25	it	it	PRON
admet-1465	248	26	was	be	AUX
admet-1465	248	27	concluded	conclude	VERB
admet-1465	248	28	that	that	SCONJ
admet-1465	248	29	the	the	DET
admet-1465	248	30	use	use	NOUN
admet-1465	248	31	of	of	ADP
admet-1465	248	32	both	both	DET
admet-1465	248	33	cosolvents	cosolvent	NOUN
admet-1465	248	34	can	can	AUX
admet-1465	248	35	lead	lead	VERB
admet-1465	248	36	to	to	ADP
admet-1465	248	37	the	the	DET
admet-1465	248	38	development	development	NOUN
admet-1465	248	39	of	of	ADP
admet-1465	248	40	potential	potential	ADJ
admet-1465	248	41	prolonged	prolong	VERB
admet-1465	248	42	release	release	NOUN
admet-1465	248	43	oil	oil	NOUN
admet-1465	248	44	formulation	formulation	NOUN
admet-1465	248	45	in	in	ADP
admet-1465	248	46	the	the	DET
admet-1465	248	47	form	form	NOUN
admet-1465	248	48	of	of	ADP
admet-1465	248	49	solution	solution	NOUN
admet-1465	248	50	.	.	PUNCT
admet-1465	249	1	the	the	DET
admet-1465	249	2	choice	choice	NOUN
admet-1465	249	3	of	of	ADP
admet-1465	249	4	the	the	DET
admet-1465	249	5	type	type	NOUN
admet-1465	249	6	and	and	CCONJ
admet-1465	249	7	amount	amount	NOUN
admet-1465	249	8	of	of	ADP
admet-1465	249	9	cosolvent	cosolvent	ADJ
admet-1465	249	10	determines	determine	VERB
admet-1465	249	11	the	the	DET
admet-1465	249	12	potential	potential	ADJ
admet-1465	249	13	strength	strength	NOUN
admet-1465	249	14	of	of	ADP
admet-1465	249	15	the	the	DET
admet-1465	249	16	developed	develop	VERB
admet-1465	249	17	drug	drug	NOUN
admet-1465	249	18	product	product	NOUN
admet-1465	249	19	.	.	PUNCT
admet-1465	250	1	the	the	DET
admet-1465	250	2	developed	develop	VERB
admet-1465	250	3	method	method	NOUN
admet-1465	250	4	described	describe	VERB
admet-1465	250	5	in	in	ADP
admet-1465	250	6	this	this	DET
admet-1465	250	7	article	article	NOUN
admet-1465	250	8	may	may	AUX
admet-1465	250	9	be	be	AUX
admet-1465	250	10	used	use	VERB
admet-1465	250	11	in	in	ADP
admet-1465	250	12	oil	oil	NOUN
admet-1465	250	13	-	-	PUNCT
admet-1465	250	14	based	base	VERB
admet-1465	250	15	drug	drug	NOUN
admet-1465	250	16	product	product	NOUN
admet-1465	250	17	development	development	NOUN
admet-1465	250	18	for	for	ADP
admet-1465	250	19	fast	fast	ADJ
admet-1465	250	20	and	and	CCONJ
admet-1465	250	21	direct	direct	ADJ
admet-1465	250	22	early	early	ADJ
admet-1465	250	23	preformulation	preformulation	NOUN
admet-1465	250	24	and	and	CCONJ
admet-1465	250	25	formulation	formulation	NOUN
admet-1465	250	26	screening	screening	NOUN
admet-1465	250	27	.	.	PUNCT
admet-1465	251	1	moreover	moreover	ADV
admet-1465	251	2	,	,	PUNCT
admet-1465	251	3	it	it	PRON
admet-1465	251	4	serves	serve	VERB
admet-1465	251	5	as	as	ADP
admet-1465	251	6	a	a	DET
admet-1465	251	7	basis	basis	NOUN
admet-1465	251	8	for	for	ADP
admet-1465	251	9	further	further	ADJ
admet-1465	251	10	research	research	NOUN
admet-1465	251	11	,	,	PUNCT
admet-1465	251	12	leading	lead	VERB
admet-1465	251	13	to	to	ADP
admet-1465	251	14	a	a	DET
admet-1465	251	15	standardised	standardised	ADJ
admet-1465	251	16	ivr	ivr	NOUN
admet-1465	251	17	method	method	NOUN
admet-1465	251	18	with	with	ADP
admet-1465	251	19	significance	significance	NOUN
admet-1465	251	20	in	in	ADP
admet-1465	251	21	quality	quality	NOUN
admet-1465	251	22	control	control	NOUN
admet-1465	251	23	and	and	CCONJ
admet-1465	251	24	regulatory	regulatory	ADJ
admet-1465	251	25	affairs	affair	NOUN
admet-1465	251	26	purposes	purpose	NOUN
admet-1465	251	27	.	.	PUNCT
admet-1465	252	1	acknowledgements	acknowledgement	NOUN
admet-1465	252	2	:	:	PUNCT
admet-1465	252	3	the	the	DET
admet-1465	252	4	authors	author	NOUN
admet-1465	252	5	would	would	AUX
admet-1465	252	6	like	like	VERB
admet-1465	252	7	to	to	PART
admet-1465	252	8	thank	thank	VERB
admet-1465	252	9	marieta	marieta	PROPN
admet-1465	252	10	duvnjak	duvnjak	PROPN
admet-1465	252	11	romić	romić	PROPN
admet-1465	252	12	,	,	PUNCT
admet-1465	252	13	ph.d	ph.d	PROPN
admet-1465	252	14	.	.	PUNCT
admet-1465	253	1	for	for	ADP
admet-1465	253	2	her	her	PRON
admet-1465	253	3	contribution	contribution	NOUN
admet-1465	253	4	in	in	ADP
admet-1465	253	5	designing	designing	NOUN
admet-1465	253	6	of	of	ADP
admet-1465	253	7	the	the	DET
admet-1465	253	8	experiments	experiment	NOUN
admet-1465	253	9	and	and	CCONJ
admet-1465	253	10	preparing	prepare	VERB
admet-1465	253	11	of	of	ADP
admet-1465	253	12	the	the	DET
admet-1465	253	13	manuscript	manuscript	NOUN
admet-1465	253	14	.	.	PUNCT
admet-1465	254	1	conflict	conflict	NOUN
admet-1465	254	2	of	of	ADP
admet-1465	254	3	interest	interest	NOUN
admet-1465	254	4	:	:	PUNCT
admet-1465	254	5	the	the	DET
admet-1465	254	6	authors	author	NOUN
admet-1465	254	7	declare	declare	VERB
admet-1465	254	8	no	no	DET
admet-1465	254	9	conflict	conflict	NOUN
admet-1465	254	10	of	of	ADP
admet-1465	254	11	interest	interest	NOUN
admet-1465	254	12	.	.	PUNCT
admet-1465	255	1	references	reference	NOUN
admet-1465	255	2	[	[	X
admet-1465	255	3	1	1	NUM
admet-1465	255	4	]	]	X
admet-1465	255	5	b.	b.	PROPN
admet-1465	255	6	abrahamson	abrahamson	PROPN
admet-1465	255	7	,	,	PUNCT
admet-1465	255	8	a.l	a.l	PROPN
admet-1465	255	9	.	.	NOUN
admet-1465	255	10	ungell	ungell	PROPN
admet-1465	255	11	.	.	PUNCT
admet-1465	256	1	biopharmaceutical	biopharmaceutical	ADJ
admet-1465	256	2	support	support	NOUN
admet-1465	256	3	in	in	ADP
admet-1465	256	4	formulation	formulation	NOUN
admet-1465	256	5	development	development	NOUN
admet-1465	256	6	.	.	PUNCT
admet-1465	257	1	in	in	ADP
admet-1465	257	2	:	:	PUNCT
admet-1465	257	3	pharmaceutical	pharmaceutical	ADJ
admet-1465	257	4	preformulation	preformulation	NOUN
admet-1465	257	5	and	and	CCONJ
admet-1465	257	6	formulation	formulation	NOUN
admet-1465	257	7	;	;	PUNCT
admet-1465	257	8	gibson	gibson	PROPN
admet-1465	257	9	m	m	PROPN
admet-1465	257	10	,	,	PUNCT
admet-1465	257	11	ed	ed	PROPN
admet-1465	257	12	.	.	PROPN
admet-1465	257	13	,	,	PUNCT
admet-1465	257	14	crc	crc	PROPN
admet-1465	257	15	press	press	PROPN
admet-1465	257	16	llc	llc	PROPN
admet-1465	257	17	,	,	PUNCT
admet-1465	257	18	boca	boca	PROPN
admet-1465	257	19	raton	raton	PROPN
admet-1465	257	20	,	,	PUNCT
admet-1465	257	21	usa	usa	PROPN
admet-1465	257	22	,	,	PUNCT
admet-1465	257	23	2004	2004	NUM
admet-1465	257	24	,	,	PUNCT
admet-1465	257	25	p.	p.	NOUN
admet-1465	257	26	239	239	NUM
admet-1465	257	27	-	-	SYM
admet-1465	257	28	291	291	NUM
admet-1465	257	29	.	.	PUNCT
admet-1465	258	1	[	[	X
admet-1465	258	2	2	2	NUM
admet-1465	258	3	]	]	PUNCT
admet-1465	258	4	m.	m.	NOUN
admet-1465	258	5	jug	jug	NOUN
admet-1465	258	6	,	,	PUNCT
admet-1465	258	7	a.	a.	PROPN
admet-1465	258	8	hafner	hafner	PROPN
admet-1465	258	9	,	,	PUNCT
admet-1465	258	10	j.	j.	PROPN
admet-1465	258	11	lovrić	lovrić	PROPN
admet-1465	258	12	,	,	PUNCT
admet-1465	258	13	m.	m.	PROPN
admet-1465	258	14	lusina	lusina	PROPN
admet-1465	258	15	kregar	kregar	PROPN
admet-1465	258	16	,	,	PUNCT
admet-1465	258	17	i.	i.	PROPN
admet-1465	258	18	pepić	pepić	PROPN
admet-1465	258	19	,	,	PUNCT
admet-1465	258	20	ž	ž	PROPN
admet-1465	258	21	.	.	PROPN
admet-1465	258	22	vanić	vanić	PROPN
admet-1465	258	23	,	,	PUNCT
admet-1465	258	24	b.	b.	PROPN
admet-1465	258	25	cetina	cetina	PROPN
admet-1465	258	26	-	-	PUNCT
admet-1465	258	27	čižmek	čižmek	PROPN
admet-1465	258	28	,	,	PUNCT
admet-1465	258	29	j.	j.	PROPN
admet-1465	258	30	filipović	filipović	PROPN
admet-1465	258	31	-	-	PUNCT
admet-1465	258	32	grčić	grčić	NOUN
admet-1465	258	33	.	.	PUNCT
admet-1465	259	1	in	in	ADP
admet-1465	259	2	vitro	vitro	X
admet-1465	259	3	dissolution	dissolution	NOUN
admet-1465	259	4	/	/	SYM
admet-1465	259	5	release	release	NOUN
admet-1465	259	6	methods	method	NOUN
admet-1465	259	7	for	for	ADP
admet-1465	259	8	mucosal	mucosal	NOUN
admet-1465	259	9	delivery	delivery	NOUN
admet-1465	259	10	systems	system	NOUN
admet-1465	259	11	.	.	PUNCT
admet-1465	260	1	admet	admet	PROPN
admet-1465	260	2	and	and	CCONJ
admet-1465	260	3	dmpk	dmpk	NOUN
admet-1465	260	4	5(3	5(3	NUM
admet-1465	260	5	)	)	PUNCT
admet-1465	260	6	(	(	PUNCT
admet-1465	260	7	2017	2017	NUM
admet-1465	260	8	)	)	PUNCT
admet-1465	260	9	173182	173182	NUM
admet-1465	260	10	.	.	PUNCT
admet-1465	261	1	http://dx.doi.org/10.1016/j.jpba.2017.06.072	http://dx.doi.org/10.1016/j.jpba.2017.06.072	NOUN
admet-1465	261	2	[	[	X
admet-1465	261	3	3	3	NUM
admet-1465	261	4	]	]	PUNCT
admet-1465	261	5	m.	m.	NOUN
admet-1465	261	6	jug	jug	NOUN
admet-1465	261	7	,	,	PUNCT
admet-1465	261	8	a.	a.	PROPN
admet-1465	261	9	hafner	hafner	PROPN
admet-1465	261	10	,	,	PUNCT
admet-1465	261	11	j.	j.	PROPN
admet-1465	261	12	lovrić	lovrić	PROPN
admet-1465	261	13	,	,	PUNCT
admet-1465	261	14	m.	m.	PROPN
admet-1465	261	15	lusina	lusina	PROPN
admet-1465	261	16	kregar	kregar	PROPN
admet-1465	261	17	,	,	PUNCT
admet-1465	261	18	i.	i.	PROPN
admet-1465	261	19	pepić	pepić	PROPN
admet-1465	261	20	,	,	PUNCT
admet-1465	261	21	ž	ž	PROPN
admet-1465	261	22	.	.	PROPN
admet-1465	261	23	vanić	vanić	PROPN
admet-1465	261	24	,	,	PUNCT
admet-1465	261	25	b.	b.	PROPN
admet-1465	261	26	cetina	cetina	PROPN
admet-1465	261	27	-	-	PUNCT
admet-1465	261	28	čižmek	čižmek	PROPN
admet-1465	261	29	,	,	PUNCT
admet-1465	261	30	j.	j.	PROPN
admet-1465	261	31	filipović	filipović	PROPN
admet-1465	261	32	-	-	PUNCT
admet-1465	261	33	grčić	grčić	PROPN
admet-1465	261	34	.	.	PUNCT
admet-1465	262	1	an	an	DET
admet-1465	262	2	overview	overview	NOUN
admet-1465	262	3	of	of	ADP
admet-1465	262	4	in	in	ADP
admet-1465	262	5	vitro	vitro	X
admet-1465	262	6	dissolution	dissolution	NOUN
admet-1465	262	7	/	/	SYM
admet-1465	262	8	release	release	NOUN
admet-1465	262	9	methods	method	NOUN
admet-1465	262	10	for	for	ADP
admet-1465	262	11	novel	novel	ADJ
admet-1465	262	12	mucosal	mucosal	NOUN
admet-1465	262	13	drug	drug	NOUN
admet-1465	262	14	delivery	delivery	NOUN
admet-1465	262	15	systems	system	NOUN
admet-1465	262	16	.	.	PUNCT
admet-1465	263	1	journal	journal	NOUN
admet-1465	263	2	of	of	ADP
admet-1465	263	3	pharmaceutical	pharmaceutical	NOUN
admet-1465	263	4	and	and	CCONJ
admet-1465	263	5	biomedical	biomedical	ADJ
admet-1465	263	6	analysis	analysis	NOUN
admet-1465	263	7	147	147	NUM
admet-1465	263	8	(	(	PUNCT
admet-1465	263	9	2018	2018	NUM
admet-1465	263	10	)	)	PUNCT
admet-1465	263	11	350	350	NUM
admet-1465	263	12	-	-	SYM
admet-1465	263	13	366	366	NUM
admet-1465	263	14	.	.	PUNCT
admet-1465	264	1	https://doi.org/10.1016/j.jpba.2017.06.072	https://doi.org/10.1016/j.jpba.2017.06.072	NOUN
admet-1465	264	2	[	[	X
admet-1465	264	3	4	4	NUM
admet-1465	264	4	]	]	PUNCT
admet-1465	264	5	m.	m.	NOUN
admet-1465	264	6	probst	probst	PROPN
admet-1465	264	7	,	,	PUNCT
admet-1465	264	8	m.	m.	NOUN
admet-1465	264	9	schmidt	schmidt	PROPN
admet-1465	264	10	,	,	PUNCT
admet-1465	264	11	k.	k.	PROPN
admet-1465	264	12	tietz	tietz	PROPN
admet-1465	264	13	,	,	PUNCT
admet-1465	264	14	s.	s.	PROPN
admet-1465	264	15	klein	klein	PROPN
admet-1465	264	16	,	,	PUNCT
admet-1465	264	17	w.	w.	PROPN
admet-1465	264	18	weitschies	weitschies	PROPN
admet-1465	264	19	,	,	PUNCT
admet-1465	264	20	a.	a.	PROPN
admet-1465	264	21	seidlitz	seidlitz	PROPN
admet-1465	264	22	.	.	PUNCT
admet-1465	265	1	in	in	ADP
admet-1465	265	2	vitro	vitro	X
admet-1465	265	3	dissolution	dissolution	NOUN
admet-1465	265	4	testing	testing	NOUN
admet-1465	265	5	of	of	ADP
admet-1465	265	6	parenteral	parenteral	ADJ
admet-1465	265	7	aqueous	aqueous	ADJ
admet-1465	265	8	solutions	solution	NOUN
admet-1465	265	9	and	and	CCONJ
admet-1465	265	10	oily	oily	ADJ
admet-1465	265	11	suspensions	suspension	NOUN
admet-1465	265	12	of	of	ADP
admet-1465	265	13	paracetamol	paracetamol	NOUN
admet-1465	265	14	and	and	CCONJ
admet-1465	265	15	prednisolone	prednisolone	PROPN
admet-1465	265	16	.	.	PROPN
admet-1465	265	17	international	international	PROPN
admet-1465	265	18	journal	journal	PROPN
admet-1465	265	19	of	of	ADP
admet-1465	265	20	pharmaceutics	pharmaceutic	NOUN
admet-1465	265	21	532(1	532(1	NUM
admet-1465	265	22	)	)	PUNCT
admet-1465	265	23	(	(	PUNCT
admet-1465	265	24	2017	2017	NUM
admet-1465	265	25	)	)	PUNCT
admet-1465	265	26	519–527	519–527	NUM
admet-1465	265	27	.	.	PUNCT
admet-1465	266	1	https://doi.org/10.1016/j.ijpharm.2017.09.052	https://doi.org/10.1016/j.ijpharm.2017.09.052	PROPN
admet-1465	267	1	[	[	X
admet-1465	267	2	5	5	NUM
admet-1465	267	3	]	]	PUNCT
admet-1465	267	4	d.	d.	PROPN
admet-1465	267	5	j.	j.	PROPN
admet-1465	267	6	burgess	burgess	PROPN
admet-1465	267	7	,	,	PUNCT
admet-1465	267	8	d.	d.	PROPN
admet-1465	267	9	j.	j.	PROPN
admet-1465	267	10	crommelin	crommelin	PROPN
admet-1465	267	11	,	,	PUNCT
admet-1465	267	12	a.s	a.s	PROPN
admet-1465	267	13	.	.	PROPN
admet-1465	267	14	hussain	hussain	PROPN
admet-1465	267	15	,	,	PUNCT
admet-1465	267	16	m.	m.	PROPN
admet-1465	267	17	l.	l.	PROPN
admet-1465	267	18	chen	chen	PROPN
admet-1465	267	19	.	.	PUNCT
admet-1465	268	1	assuring	assure	VERB
admet-1465	268	2	quality	quality	NOUN
admet-1465	268	3	and	and	CCONJ
admet-1465	268	4	performance	performance	NOUN
admet-1465	268	5	of	of	ADP
admet-1465	268	6	sustained	sustained	ADJ
admet-1465	268	7	and	and	CCONJ
admet-1465	268	8	controlled	control	VERB
admet-1465	268	9	release	release	NOUN
admet-1465	268	10	parenterals	parenteral	NOUN
admet-1465	268	11	.	.	PUNCT
admet-1465	269	1	european	european	ADJ
admet-1465	269	2	journal	journal	PROPN
admet-1465	269	3	of	of	ADP
admet-1465	269	4	pharmaceutical	pharmaceutical	PROPN
admet-1465	269	5	sciences	sciences	PROPN
admet-1465	269	6	21(5	21(5	NUM
admet-1465	269	7	)	)	PUNCT
admet-1465	269	8	(	(	PUNCT
admet-1465	269	9	2004	2004	NUM
admet-1465	269	10	)	)	PUNCT
admet-1465	269	11	679	679	NUM
admet-1465	269	12	–	–	PUNCT
admet-1465	269	13	690	690	NUM
admet-1465	269	14	.	.	PUNCT
admet-1465	270	1	https://doi.org/10.1208/ps060111	https://doi.org/10.1208/ps060111	PUNCT
admet-1465	271	1	[	[	X
admet-1465	271	2	6	6	NUM
admet-1465	271	3	]	]	PUNCT
admet-1465	271	4	v.	v.	CCONJ
admet-1465	271	5	gray	gray	ADJ
admet-1465	271	6	,	,	PUNCT
admet-1465	271	7	s.	s.	PROPN
admet-1465	271	8	cady	cady	PROPN
admet-1465	271	9	,	,	PUNCT
admet-1465	271	10	d.	d.	PROPN
admet-1465	271	11	curran	curran	PROPN
admet-1465	271	12	,	,	PUNCT
admet-1465	271	13	j.	j.	PROPN
admet-1465	271	14	demuth	demuth	PROPN
admet-1465	271	15	,	,	PUNCT
admet-1465	271	16	o.	o.	PROPN
admet-1465	271	17	eradiri	eradiri	PROPN
admet-1465	271	18	,	,	PUNCT
admet-1465	271	19	m.	m.	NOUN
admet-1465	271	20	hussain	hussain	PROPN
admet-1465	271	21	,	,	PUNCT
admet-1465	271	22	j.	j.	PROPN
admet-1465	271	23	krämer	krämer	PROPN
admet-1465	271	24	,	,	PUNCT
admet-1465	271	25	j.	j.	PROPN
admet-1465	271	26	shabushnig	shabushnig	PROPN
admet-1465	271	27	,	,	PUNCT
admet-1465	271	28	e.	e.	PROPN
admet-1465	271	29	stippler	stippler	PROPN
admet-1465	271	30	.	.	PUNCT
admet-1465	272	1	in	in	ADP
admet-1465	272	2	vitro	vitro	X
admet-1465	272	3	release	release	NOUN
admet-1465	272	4	test	test	NOUN
admet-1465	272	5	methods	method	NOUN
admet-1465	272	6	for	for	ADP
admet-1465	272	7	drug	drug	NOUN
admet-1465	272	8	formulations	formulation	NOUN
admet-1465	272	9	for	for	ADP
admet-1465	272	10	parenteral	parenteral	ADJ
admet-1465	272	11	applications	application	NOUN
admet-1465	272	12	.	.	PUNCT
admet-1465	273	1	dissolution	dissolution	PROPN
admet-1465	273	2	technologies	technology	NOUN
admet-1465	273	3	25(4	25(4	NOUN
admet-1465	273	4	)	)	PUNCT
admet-1465	273	5	(	(	PUNCT
admet-1465	273	6	2018	2018	NUM
admet-1465	273	7	)	)	PUNCT
admet-1465	273	8	8	8	NUM
admet-1465	273	9	-	-	SYM
admet-1465	273	10	13	13	NUM
admet-1465	273	11	.	.	PUNCT
admet-1465	273	12	https://doi.org/10.14227/dt250418p8	https://doi.org/10.14227/dt250418p8	VERB
admet-1465	273	13	http://dx.doi.org/10.1016/j.jpba.2017.06.072	http://dx.doi.org/10.1016/j.jpba.2017.06.072	PROPN
admet-1465	273	14	https://doi.org/10.1016/j.jpba.2017.06.072	https://doi.org/10.1016/j.jpba.2017.06.072	NOUN
admet-1465	273	15	https://doi.org/10.1016/j.jpba.2017.06.072	https://doi.org/10.1016/j.jpba.2017.06.072	NOUN
admet-1465	273	16	https://doi.org/10.1016/j.ijpharm.2017.09.052	https://doi.org/10.1016/j.ijpharm.2017.09.052	PROPN
admet-1465	273	17	https://doi.org/10.1208/ps060111	https://doi.org/10.1208/ps060111	PRON
admet-1465	273	18	https://doi.org/10.14227/dt250418p8	https://doi.org/10.14227/dt250418p8	VERB
admet-1465	273	19	admet	admet	PROPN
admet-1465	273	20	&	&	CCONJ
admet-1465	273	21	dmpk	dmpk	PROPN
admet-1465	273	22	10(4	10(4	NUM
admet-1465	273	23	)	)	PUNCT
admet-1465	273	24	(	(	PUNCT
admet-1465	273	25	2022	2022	NUM
admet-1465	273	26	)	)	PUNCT
admet-1465	273	27	315	315	NUM
admet-1465	273	28	-	-	SYM
admet-1465	273	29	329	329	NUM
admet-1465	273	30	dexamethasone	dexamethasone	NOUN
admet-1465	273	31	release	release	NOUN
admet-1465	273	32	from	from	ADP
admet-1465	273	33	the	the	DET
admet-1465	273	34	oil	oil	NOUN
admet-1465	273	35	solutions	solution	NOUN
admet-1465	273	36	doi	doi	NOUN
admet-1465	273	37	:	:	PUNCT
admet-1465	273	38	https://doi.org/10.5599/admet.1465	https://doi.org/10.5599/admet.1465	ADJ
admet-1465	273	39	329	329	NUM
admet-1465	273	40	[	[	X
admet-1465	273	41	7	7	NUM
admet-1465	273	42	]	]	PUNCT
admet-1465	273	43	a.	a.	NOUN
admet-1465	273	44	owen	owen	PROPN
admet-1465	273	45	,	,	PUNCT
admet-1465	273	46	s.	s.	PROPN
admet-1465	273	47	rannard	rannard	PROPN
admet-1465	273	48	.	.	PUNCT
admet-1465	274	1	strengths	strength	NOUN
admet-1465	274	2	,	,	PUNCT
admet-1465	274	3	weaknesses	weakness	NOUN
admet-1465	274	4	,	,	PUNCT
admet-1465	274	5	opportunities	opportunity	NOUN
admet-1465	274	6	and	and	CCONJ
admet-1465	274	7	challenges	challenge	NOUN
admet-1465	274	8	for	for	ADP
admet-1465	274	9	long	long	ADJ
admet-1465	274	10	acting	act	VERB
admet-1465	274	11	injectable	injectable	ADJ
admet-1465	274	12	therdruges	therdruge	NOUN
admet-1465	274	13	:	:	PUNCT
admet-1465	274	14	insights	insight	NOUN
admet-1465	274	15	for	for	ADP
admet-1465	274	16	applications	application	NOUN
admet-1465	274	17	in	in	ADP
admet-1465	274	18	hiv	hiv	PROPN
admet-1465	274	19	therapy	therapy	NOUN
admet-1465	274	20	.	.	PUNCT
admet-1465	275	1	advanced	advanced	ADJ
admet-1465	275	2	drug	drug	NOUN
admet-1465	275	3	delivery	delivery	NOUN
admet-1465	275	4	reviews	review	NOUN
admet-1465	275	5	103	103	NUM
admet-1465	275	6	(	(	PUNCT
admet-1465	275	7	2016	2016	NUM
admet-1465	275	8	)	)	PUNCT
admet-1465	275	9	114156	114156	NUM
admet-1465	275	10	.	.	PUNCT
admet-1465	276	1	https://doi.org/10.1016/j.addr.2016.02.003	https://doi.org/10.1016/j.addr.2016.02.003	NUM
admet-1465	276	2	[	[	X
admet-1465	276	3	8	8	NUM
admet-1465	276	4	]	]	PUNCT
admet-1465	276	5	s.	s.	PROPN
admet-1465	276	6	weng	weng	PROPN
admet-1465	276	7	larsen	larsen	PROPN
admet-1465	276	8	,	,	PUNCT
admet-1465	276	9	m.a	m.a	PROPN
admet-1465	276	10	.	.	PROPN
admet-1465	276	11	thing	thing	NOUN
admet-1465	276	12	,	,	PUNCT
admet-1465	276	13	c.	c.	PROPN
admet-1465	276	14	larsen	larsen	PROPN
admet-1465	276	15	c.	c.	PROPN
admet-1465	276	16	oily	oily	ADV
admet-1465	276	17	(	(	PUNCT
admet-1465	276	18	lipophilic	lipophilic	ADJ
admet-1465	276	19	)	)	PUNCT
admet-1465	276	20	solutions	solution	NOUN
admet-1465	276	21	and	and	CCONJ
admet-1465	276	22	suspensions	suspension	NOUN
admet-1465	276	23	,	,	PUNCT
admet-1465	276	24	in	in	ADP
admet-1465	276	25	:	:	PUNCT
admet-1465	276	26	long	long	ADJ
admet-1465	276	27	acting	acting	NOUN
admet-1465	276	28	injections	injection	NOUN
admet-1465	276	29	and	and	CCONJ
admet-1465	276	30	implants	implant	NOUN
admet-1465	276	31	.	.	PUNCT
admet-1465	277	1	j.	j.	PROPN
admet-1465	277	2	c.	c.	PROPN
admet-1465	277	3	wright	wright	PROPN
admet-1465	277	4	,	,	PUNCT
admet-1465	277	5	d.	d.	PROPN
admet-1465	277	6	j.	j.	PROPN
admet-1465	277	7	burgess	burgess	PROPN
admet-1465	277	8	,	,	PUNCT
admet-1465	277	9	eds	eds	PROPN
admet-1465	277	10	.	.	PROPN
admet-1465	277	11	,	,	PUNCT
admet-1465	277	12	springer	springer	NOUN
admet-1465	277	13	,	,	PUNCT
admet-1465	277	14	new	new	PROPN
admet-1465	277	15	york	york	PROPN
admet-1465	277	16	,	,	PUNCT
admet-1465	277	17	usa	usa	PROPN
admet-1465	277	18	,	,	PUNCT
admet-1465	277	19	2012	2012	NUM
admet-1465	277	20	,	,	PUNCT
admet-1465	277	21	p.	p.	NOUN
admet-1465	277	22	113	113	NUM
admet-1465	277	23	-	-	SYM
admet-1465	277	24	136	136	NUM
admet-1465	277	25	.	.	PUNCT
admet-1465	278	1	[	[	X
admet-1465	278	2	9	9	NUM
admet-1465	278	3	]	]	X
admet-1465	278	4	j.	j.	PROPN
admet-1465	278	5	zuidema	zuidema	PROPN
admet-1465	278	6	,	,	PUNCT
admet-1465	278	7	f.	f.	PROPN
admet-1465	278	8	a.	a.	PROPN
admet-1465	278	9	j.	j.	PROPN
admet-1465	278	10	m.	m.	PROPN
admet-1465	278	11	pieters	pieters	PROPN
admet-1465	278	12	,	,	PUNCT
admet-1465	278	13	g.	g.	PROPN
admet-1465	278	14	s.	s.	PROPN
admet-1465	278	15	m.	m.	PROPN
admet-1465	278	16	j.	j.	PROPN
admet-1465	278	17	e.	e.	PROPN
admet-1465	278	18	duchateau	duchateau	PROPN
admet-1465	278	19	.	.	PUNCT
admet-1465	279	1	release	release	NOUN
admet-1465	279	2	and	and	CCONJ
admet-1465	279	3	absorption	absorption	NOUN
admet-1465	279	4	rate	rate	NOUN
admet-1465	279	5	aspects	aspect	NOUN
admet-1465	279	6	of	of	ADP
admet-1465	279	7	intramuscularly	intramuscularly	ADV
admet-1465	279	8	injected	inject	VERB
admet-1465	279	9	pharmaceuticals	pharmaceutical	NOUN
admet-1465	279	10	.	.	PUNCT
admet-1465	280	1	international	international	ADJ
admet-1465	280	2	journal	journal	PROPN
admet-1465	280	3	of	of	ADP
admet-1465	280	4	pharmaceutics	pharmaceutic	NOUN
admet-1465	280	5	47	47	NUM
admet-1465	280	6	(	(	PUNCT
admet-1465	280	7	1988	1988	NUM
admet-1465	280	8	)	)	PUNCT
admet-1465	280	9	1	1	NUM
admet-1465	280	10	-	-	SYM
admet-1465	280	11	12	12	NUM
admet-1465	280	12	.	.	PUNCT
admet-1465	281	1	https://doi.org/10.1016/0378-5173(88)90209-8	https://doi.org/10.1016/0378-5173(88)90209-8	NOUN
admet-1465	282	1	[	[	X
admet-1465	282	2	10	10	NUM
admet-1465	282	3	]	]	X
admet-1465	282	4	s.	s.	PROPN
admet-1465	282	5	spanarello	spanarello	PROPN
admet-1465	282	6	,	,	PUNCT
admet-1465	282	7	t.	t.	PROPN
admet-1465	282	8	la	la	PROPN
admet-1465	282	9	ferla	ferla	PROPN
admet-1465	282	10	.	.	PUNCT
admet-1465	283	1	the	the	DET
admet-1465	283	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1465	283	3	of	of	ADP
admet-1465	283	4	long	long	ADV
admet-1465	283	5	-	-	PUNCT
admet-1465	283	6	acting	act	VERB
admet-1465	283	7	antipsychotic	antipsychotic	ADJ
admet-1465	283	8	medications	medication	NOUN
admet-1465	283	9	.	.	PUNCT
admet-1465	284	1	current	current	ADJ
admet-1465	284	2	clinical	clinical	ADJ
admet-1465	284	3	pharmacology	pharmacology	NOUN
admet-1465	284	4	9(3	9(3	NUM
admet-1465	284	5	)	)	PUNCT
admet-1465	284	6	(	(	PUNCT
admet-1465	284	7	2014	2014	NUM
admet-1465	284	8	)	)	PUNCT
admet-1465	284	9	310	310	NUM
admet-1465	284	10	-	-	SYM
admet-1465	284	11	317	317	NUM
admet-1465	284	12	.	.	PUNCT
admet-1465	284	13	https://doi.org/10.2174/15748847113089990051	https://doi.org/10.2174/15748847113089990051	PUNCT
admet-1465	285	1	[	[	X
admet-1465	285	2	11	11	NUM
admet-1465	285	3	]	]	PUNCT
admet-1465	285	4	pubchem	pubchem	NOUN
admet-1465	285	5	,	,	PUNCT
admet-1465	285	6	https://pubchem.ncbi.nlm.nih.gov/compound/dexamethasone	https://pubchem.ncbi.nlm.nih.gov/compound/dexamethasone	PROPN
admet-1465	285	7	(	(	PUNCT
admet-1465	285	8	accesed	accese	VERB
admet-1465	285	9	12th	12th	ADJ
admet-1465	285	10	july	july	PROPN
admet-1465	285	11	2022	2022	NUM
admet-1465	285	12	)	)	PUNCT
admet-1465	286	1	[	[	X
admet-1465	286	2	12	12	NUM
admet-1465	286	3	]	]	X
admet-1465	286	4	o.	o.	PROPN
admet-1465	286	5	suitthimeathegorn	suitthimeathegorn	PROPN
admet-1465	286	6	,	,	PUNCT
admet-1465	286	7	j.	j.	PROPN
admet-1465	286	8	a.	a.	PROPN
admet-1465	286	9	turton	turton	PROPN
admet-1465	286	10	,	,	PUNCT
admet-1465	286	11	h.	h.	PROPN
admet-1465	286	12	mizuuchi	mizuuchi	PROPN
admet-1465	286	13	,	,	PUNCT
admet-1465	286	14	a.	a.	NOUN
admet-1465	286	15	t.	t.	PROPN
admet-1465	286	16	florence	florence	NOUN
admet-1465	286	17	.	.	PUNCT
admet-1465	287	1	intramuscular	intramuscular	ADJ
admet-1465	287	2	absorption	absorption	NOUN
admet-1465	287	3	and	and	CCONJ
admet-1465	287	4	biodistribution	biodistribution	NOUN
admet-1465	287	5	of	of	ADP
admet-1465	287	6	dexamethasone	dexamethasone	NOUN
admet-1465	287	7	from	from	ADP
admet-1465	287	8	non	non	ADJ
admet-1465	287	9	-	-	ADJ
admet-1465	287	10	aqueous	aqueous	ADJ
admet-1465	287	11	emulsions	emulsion	NOUN
admet-1465	287	12	in	in	ADP
admet-1465	287	13	the	the	DET
admet-1465	287	14	rat	rat	NOUN
admet-1465	287	15	.	.	PROPN
admet-1465	287	16	international	international	ADJ
admet-1465	287	17	journal	journal	PROPN
admet-1465	287	18	of	of	ADP
admet-1465	287	19	pharmaceutics	pharmaceutic	NOUN
admet-1465	287	20	331(2	331(2	NUM
admet-1465	287	21	)	)	PUNCT
admet-1465	287	22	(	(	PUNCT
admet-1465	287	23	2007	2007	NUM
admet-1465	287	24	)	)	PUNCT
admet-1465	287	25	204	204	NUM
admet-1465	287	26	-	-	SYM
admet-1465	287	27	210	210	NUM
admet-1465	287	28	.	.	PUNCT
admet-1465	288	1	https://doi.org/10.1016/j.ijpharm.2006.11.062	https://doi.org/10.1016/j.ijpharm.2006.11.062	PRON
admet-1465	289	1	[	[	X
admet-1465	289	2	13	13	NUM
admet-1465	289	3	]	]	PUNCT
admet-1465	289	4	r.	r.	PROPN
admet-1465	289	5	macoon	macoon	PROPN
admet-1465	289	6	,	,	PUNCT
admet-1465	289	7	t.	t.	PROPN
admet-1465	289	8	guerriero	guerriero	PROPN
admet-1465	289	9	,	,	PUNCT
admet-1465	289	10	a.	a.	PROPN
admet-1465	289	11	chauhan	chauhan	PROPN
admet-1465	289	12	.	.	PROPN
admet-1465	289	13	extended	extend	VERB
admet-1465	289	14	release	release	NOUN
admet-1465	289	15	of	of	ADP
admet-1465	289	16	dexamethasone	dexamethasone	NOUN
admet-1465	289	17	from	from	ADP
admet-1465	289	18	oleogel	oleogel	NOUN
admet-1465	289	19	based	base	VERB
admet-1465	289	20	rods	rod	NOUN
admet-1465	289	21	.	.	PUNCT
admet-1465	290	1	journal	journal	NOUN
admet-1465	290	2	of	of	ADP
admet-1465	290	3	colloid	colloid	NOUN
admet-1465	290	4	and	and	CCONJ
admet-1465	290	5	interface	interface	NOUN
admet-1465	290	6	science	science	NOUN
admet-1465	290	7	555	555	NUM
admet-1465	290	8	(	(	PUNCT
admet-1465	290	9	2019	2019	NUM
admet-1465	290	10	)	)	PUNCT
admet-1465	290	11	331	331	NUM
admet-1465	290	12	-	-	SYM
admet-1465	290	13	341	341	NUM
admet-1465	290	14	.	.	PUNCT
admet-1465	291	1	https://doi.org/10.1016/j.jcis.2019.07.082	https://doi.org/10.1016/j.jcis.2019.07.082	PROPN
admet-1465	292	1	[	[	X
admet-1465	292	2	14	14	NUM
admet-1465	292	3	]	]	PUNCT
admet-1465	292	4	x.	x.	NOUN
admet-1465	292	5	lu	lu	PROPN
admet-1465	292	6	,	,	PUNCT
admet-1465	292	7	r.	r.	PROPN
admet-1465	292	8	lozano	lozano	PROPN
admet-1465	292	9	,	,	PUNCT
admet-1465	292	10	p.	p.	NOUN
admet-1465	292	11	shah	shah	NOUN
admet-1465	292	12	.	.	PUNCT
admet-1465	293	1	in	in	ADP
admet-1465	293	2	-	-	PUNCT
admet-1465	293	3	situ	situ	NOUN
admet-1465	293	4	dissolution	dissolution	NOUN
admet-1465	293	5	testing	testing	NOUN
admet-1465	293	6	using	use	VERB
admet-1465	293	7	different	different	ADJ
admet-1465	293	8	uv	uv	NOUN
admet-1465	293	9	fiber	fiber	NOUN
admet-1465	293	10	optic	optic	NOUN
admet-1465	293	11	probes	probe	NOUN
admet-1465	293	12	and	and	CCONJ
admet-1465	293	13	instruments	instrument	NOUN
admet-1465	293	14	.	.	PUNCT
admet-1465	294	1	dissolution	dissolution	PROPN
admet-1465	294	2	technologies	technology	NOUN
admet-1465	294	3	10	10	NUM
admet-1465	294	4	(	(	PUNCT
admet-1465	294	5	2003	2003	NUM
admet-1465	294	6	)	)	PUNCT
admet-1465	294	7	6	6	NUM
admet-1465	294	8	-	-	SYM
admet-1465	294	9	16	16	NUM
admet-1465	294	10	.	.	PUNCT
admet-1465	294	11	https://doi.org/10.14227/dt100403p6	https://doi.org/10.14227/dt100403p6	NOUN
admet-1465	295	1	[	[	X
admet-1465	295	2	15	15	NUM
admet-1465	295	3	]	]	X
admet-1465	295	4	i.	i.	NOUN
admet-1465	295	5	nir	nir	PROPN
admet-1465	295	6	,	,	PUNCT
admet-1465	295	7	x.	x.	NOUN
admet-1465	295	8	lu	lu	PROPN
admet-1465	295	9	.	.	PUNCT
admet-1465	296	1	in	in	ADP
admet-1465	296	2	situ	situ	ADJ
admet-1465	296	3	uv	uv	NOUN
admet-1465	296	4	fiber	fiber	NOUN
admet-1465	296	5	optics	optic	NOUN
admet-1465	296	6	for	for	ADP
admet-1465	296	7	dissolution	dissolution	NOUN
admet-1465	296	8	testing	testing	NOUN
admet-1465	296	9	–	–	PUNCT
admet-1465	296	10	what	what	PRON
admet-1465	296	11	,	,	PUNCT
admet-1465	296	12	why	why	SCONJ
admet-1465	296	13	,	,	PUNCT
admet-1465	296	14	and	and	CCONJ
admet-1465	296	15	where	where	SCONJ
admet-1465	296	16	we	we	PRON
admet-1465	296	17	are	be	AUX
admet-1465	296	18	after	after	ADP
admet-1465	296	19	30	30	NUM
admet-1465	296	20	years	year	NOUN
admet-1465	296	21	.	.	PUNCT
admet-1465	297	1	dissolution	dissolution	PROPN
admet-1465	297	2	technologies	technology	NOUN
admet-1465	297	3	25(3	25(3	NUM
admet-1465	297	4	)	)	PUNCT
admet-1465	297	5	(	(	PUNCT
admet-1465	297	6	2018	2018	NUM
admet-1465	297	7	)	)	PUNCT
admet-1465	297	8	70	70	NUM
admet-1465	297	9	-	-	SYM
admet-1465	297	10	77	77	NUM
admet-1465	297	11	.	.	PUNCT
admet-1465	298	1	https://doi.org/10.14227/dt250318p70	https://doi.org/10.14227/dt250318p70	NOUN
admet-1465	298	2	[	[	X
admet-1465	298	3	16	16	NUM
admet-1465	298	4	]	]	PUNCT
admet-1465	298	5	k.	k.	PROPN
admet-1465	298	6	schultz	schultz	PROPN
admet-1465	298	7	,	,	PUNCT
admet-1465	298	8	b.	b.	PROPN
admet-1465	298	9	møllgaard	møllgaard	PROPN
admet-1465	298	10	,	,	PUNCT
admet-1465	298	11	s.	s.	PROPN
admet-1465	298	12	frokjaer	frokjaer	PROPN
admet-1465	298	13	,	,	PUNCT
admet-1465	298	14	c.	c.	PROPN
admet-1465	298	15	larsen	larsen	PROPN
admet-1465	298	16	.	.	PUNCT
admet-1465	299	1	rotating	rotate	VERB
admet-1465	299	2	dialysis	dialysis	NOUN
admet-1465	299	3	cell	cell	NOUN
admet-1465	299	4	as	as	ADP
admet-1465	299	5	in	in	ADP
admet-1465	299	6	vitro	vitro	X
admet-1465	299	7	release	release	NOUN
admet-1465	299	8	method	method	NOUN
admet-1465	299	9	for	for	ADP
admet-1465	299	10	oily	oily	ADJ
admet-1465	299	11	parenteral	parenteral	ADJ
admet-1465	299	12	depot	depot	NOUN
admet-1465	299	13	solutions	solution	NOUN
admet-1465	299	14	.	.	PUNCT
admet-1465	300	1	international	international	ADJ
admet-1465	300	2	journal	journal	PROPN
admet-1465	300	3	of	of	ADP
admet-1465	300	4	pharmaceutics	pharmaceutic	NOUN
admet-1465	300	5	157(2	157(2	NUM
admet-1465	300	6	)	)	PUNCT
admet-1465	300	7	(	(	PUNCT
admet-1465	300	8	1997	1997	NUM
admet-1465	300	9	)	)	PUNCT
admet-1465	300	10	163	163	NUM
admet-1465	300	11	-	-	SYM
admet-1465	300	12	169	169	NUM
admet-1465	300	13	.	.	PUNCT
admet-1465	301	1	https://doi.org/10.1016/s0378-5173(97)00229-9	https://doi.org/10.1016/s0378-5173(97)00229-9	PROPN
admet-1465	302	1	[	[	X
admet-1465	302	2	17	17	NUM
admet-1465	302	3	]	]	X
admet-1465	302	4	d.	d.	PROPN
admet-1465	302	5	h.	h.	PROPN
admet-1465	302	6	larsen	larsen	PROPN
admet-1465	302	7	,	,	PUNCT
admet-1465	302	8	k.	k.	PROPN
admet-1465	302	9	fredholt	fredholt	PROPN
admet-1465	302	10	,	,	PUNCT
admet-1465	302	11	c.	c.	PROPN
admet-1465	302	12	larsen	larsen	PROPN
admet-1465	302	13	.	.	PROPN
admet-1465	303	1	assessment	assessment	NOUN
admet-1465	303	2	of	of	ADP
admet-1465	303	3	rate	rate	NOUN
admet-1465	303	4	of	of	ADP
admet-1465	303	5	drug	drug	NOUN
admet-1465	303	6	release	release	NOUN
admet-1465	303	7	from	from	ADP
admet-1465	303	8	oil	oil	NOUN
admet-1465	303	9	vehicle	vehicle	NOUN
admet-1465	303	10	using	use	VERB
admet-1465	303	11	a	a	DET
admet-1465	303	12	rotating	rotate	VERB
admet-1465	303	13	dialysis	dialysis	NOUN
admet-1465	303	14	cell	cell	NOUN
admet-1465	303	15	.	.	PUNCT
admet-1465	304	1	european	european	ADJ
admet-1465	304	2	journal	journal	PROPN
admet-1465	304	3	of	of	ADP
admet-1465	304	4	pharmaceutical	pharmaceutical	PROPN
admet-1465	304	5	sciences	science	NOUN
admet-1465	304	6	11(3	11(3	NUM
admet-1465	304	7	)	)	PUNCT
admet-1465	304	8	(	(	PUNCT
admet-1465	304	9	2000	2000	NUM
admet-1465	304	10	)	)	PUNCT
admet-1465	304	11	223	223	NUM
admet-1465	304	12	-	-	SYM
admet-1465	304	13	229	229	NUM
admet-1465	304	14	.	.	PUNCT
admet-1465	304	15	https://doi.org/10.1016/s0928-0987(00)00105-6	https://doi.org/10.1016/s0928-0987(00)00105-6	PROPN
admet-1465	305	1	[	[	X
admet-1465	305	2	18	18	NUM
admet-1465	305	3	]	]	PUNCT
admet-1465	305	4	c.-j	c.-j	PROPN
admet-1465	305	5	.	.	PUNCT
admet-1465	306	1	li	li	PROPN
admet-1465	306	2	,	,	PUNCT
admet-1465	306	3	m.-y	m.-y	PROPN
admet-1465	306	4	.	.	PUNCT
admet-1465	307	1	ku	ku	PROPN
admet-1465	307	2	,	,	PUNCT
admet-1465	307	3	c.-y	c.-y	NOUN
admet-1465	307	4	.	.	PUNCT
admet-1465	308	1	lu	lu	PROPN
admet-1465	308	2	,	,	PUNCT
admet-1465	308	3	y.-e	y.-e	PROPN
admet-1465	308	4	.	.	PUNCT
admet-1465	309	1	tien	tien	PROPN
admet-1465	309	2	,	,	PUNCT
admet-1465	309	3	w.	w.	PROPN
admet-1465	309	4	h.	h.	PROPN
admet-1465	309	5	chern	chern	PROPN
admet-1465	309	6	,	,	PUNCT
admet-1465	309	7	j.	j.	PROPN
admet-1465	309	8	huang	huang	PROPN
admet-1465	309	9	.	.	PUNCT
admet-1465	310	1	in	in	ADP
admet-1465	310	2	vitro	vitro	X
admet-1465	310	3	and	and	CCONJ
admet-1465	310	4	in	in	ADP
admet-1465	310	5	vivo	vivo	ADJ
admet-1465	310	6	release	release	NOUN
admet-1465	310	7	of	of	ADP
admet-1465	310	8	dinalbuphine	dinalbuphine	ADJ
admet-1465	310	9	sebacate	sebacate	ADJ
admet-1465	310	10	extended	extend	VERB
admet-1465	310	11	release	release	NOUN
admet-1465	310	12	formulation	formulation	NOUN
admet-1465	310	13	:	:	PUNCT
admet-1465	310	14	effect	effect	NOUN
admet-1465	310	15	of	of	ADP
admet-1465	310	16	the	the	DET
admet-1465	310	17	oil	oil	NOUN
admet-1465	310	18	ratio	ratio	NOUN
admet-1465	310	19	on	on	ADP
admet-1465	310	20	drug	drug	NOUN
admet-1465	310	21	release	release	NOUN
admet-1465	310	22	.	.	PUNCT
admet-1465	311	1	international	international	ADJ
admet-1465	311	2	journal	journal	NOUN
admet-1465	311	3	of	of	ADP
admet-1465	311	4	pharmaceutics	pharmaceutic	NOUN
admet-1465	311	5	531(1	531(1	NUM
admet-1465	311	6	)	)	PUNCT
admet-1465	311	7	(	(	PUNCT
admet-1465	311	8	2017	2017	NUM
admet-1465	311	9	)	)	PUNCT
admet-1465	311	10	306–312	306–312	NUM
admet-1465	311	11	.	.	PUNCT
admet-1465	312	1	https://doi.org/10.1016/j.ijpharm.2017.08.083	https://doi.org/10.1016/j.ijpharm.2017.08.083	X
admet-1465	313	1	[	[	X
admet-1465	313	2	19	19	NUM
admet-1465	313	3	]	]	PUNCT
admet-1465	313	4	usp	usp	NOUN
admet-1465	313	5	<	<	X
admet-1465	313	6	711	711	X
admet-1465	313	7	>	>	X
admet-1465	313	8	in	in	ADP
admet-1465	313	9	:	:	PUNCT
admet-1465	313	10	united	united	PROPN
admet-1465	313	11	states	states	PROPN
admet-1465	313	12	pharmacopoeia	pharmacopoeia	PROPN
admet-1465	313	13	usp	usp	NOUN
admet-1465	313	14	40	40	NUM
admet-1465	313	15	/	/	SYM
admet-1465	313	16	nf	nf	PROPN
admet-1465	313	17	35	35	NUM
admet-1465	313	18	.	.	PUNCT
admet-1465	314	1	the	the	DET
admet-1465	314	2	united	united	PROPN
admet-1465	314	3	states	states	PROPN
admet-1465	314	4	pharmacopeial	pharmacopeial	ADJ
admet-1465	314	5	convention	convention	PROPN
admet-1465	314	6	,	,	PUNCT
admet-1465	314	7	rockville	rockville	PROPN
admet-1465	314	8	,	,	PUNCT
admet-1465	314	9	usa	usa	PROPN
admet-1465	314	10	,	,	PUNCT
admet-1465	314	11	2015	2015	NUM
admet-1465	314	12	,	,	PUNCT
admet-1465	314	13	p.	p.	NOUN
admet-1465	314	14	588	588	NUM
admet-1465	314	15	-	-	SYM
admet-1465	314	16	598	598	NUM
admet-1465	314	17	.	.	PUNCT
admet-1465	315	1	[	[	X
admet-1465	315	2	20	20	NUM
admet-1465	315	3	]	]	X
admet-1465	315	4	v.	v.	PROPN
admet-1465	315	5	r.	r.	PROPN
admet-1465	315	6	patel	patel	PROPN
admet-1465	315	7	,	,	PUNCT
admet-1465	315	8	g.	g.	PROPN
admet-1465	315	9	g.	g.	PROPN
admet-1465	315	10	dumancas	dumancas	PROPN
admet-1465	315	11	,	,	PUNCT
admet-1465	315	12	l.	l.	PROPN
admet-1465	315	13	c.	c.	PROPN
admet-1465	315	14	kasi	kasi	PROPN
admet-1465	315	15	viswanath	viswanath	PROPN
admet-1465	315	16	,	,	PUNCT
admet-1465	315	17	r.	r.	PROPN
admet-1465	315	18	maples	maple	NOUN
admet-1465	315	19	,	,	PUNCT
admet-1465	315	20	b.	b.	PROPN
admet-1465	315	21	j.	j.	PROPN
admet-1465	315	22	j.	j.	PROPN
admet-1465	315	23	subong	subong	PROPN
admet-1465	315	24	.	.	PUNCT
admet-1465	316	1	castor	castor	NOUN
admet-1465	316	2	oil	oil	NOUN
admet-1465	316	3	:	:	PUNCT
admet-1465	316	4	properties	property	NOUN
admet-1465	316	5	,	,	PUNCT
admet-1465	316	6	uses	use	NOUN
admet-1465	316	7	,	,	PUNCT
admet-1465	316	8	and	and	CCONJ
admet-1465	316	9	optimization	optimization	NOUN
admet-1465	316	10	of	of	ADP
admet-1465	316	11	processing	processing	NOUN
admet-1465	316	12	parameters	parameter	NOUN
admet-1465	316	13	in	in	ADP
admet-1465	316	14	commercial	commercial	ADJ
admet-1465	316	15	production	production	NOUN
admet-1465	316	16	.	.	PUNCT
admet-1465	317	1	lipid	lipid	ADJ
admet-1465	317	2	insights	insight	NOUN
admet-1465	317	3	9	9	NUM
admet-1465	317	4	(	(	PUNCT
admet-1465	317	5	2016	2016	NUM
admet-1465	317	6	)	)	PUNCT
admet-1465	317	7	1	1	NUM
admet-1465	317	8	-	-	SYM
admet-1465	317	9	12	12	NUM
admet-1465	317	10	.	.	PUNCT
admet-1465	317	11	https://doi.org/10.4137/lpi.s40233	https://doi.org/10.4137/lpi.s40233	X
admet-1465	318	1	[	[	X
admet-1465	318	2	21	21	NUM
admet-1465	318	3	]	]	PUNCT
admet-1465	318	4	a.	a.	NOUN
admet-1465	318	5	šutić	šutić	PROPN
admet-1465	318	6	,	,	PUNCT
admet-1465	318	7	m.	m.	NOUN
admet-1465	318	8	duvnjak	duvnjak	PROPN
admet-1465	318	9	romić	romić	PROPN
admet-1465	318	10	,	,	PUNCT
admet-1465	318	11	s.	s.	PROPN
admet-1465	318	12	miočić	miočić	PROPN
admet-1465	318	13	,	,	PUNCT
admet-1465	318	14	b.	b.	PROPN
admet-1465	318	15	cetina	cetina	PROPN
admet-1465	318	16	-	-	PUNCT
admet-1465	318	17	čižmek	čižmek	PROPN
admet-1465	318	18	.	.	PUNCT
admet-1465	319	1	development	development	NOUN
admet-1465	319	2	of	of	ADP
admet-1465	319	3	analytical	analytical	ADJ
admet-1465	319	4	method	method	NOUN
admet-1465	319	5	for	for	ADP
admet-1465	319	6	in	in	ADP
admet-1465	319	7	vitro	vitro	X
admet-1465	319	8	release	release	NOUN
admet-1465	319	9	testing	testing	NOUN
admet-1465	319	10	of	of	ADP
admet-1465	319	11	dexamethasone	dexamethasone	NOUN
admet-1465	319	12	nanosuspensions	nanosuspension	NOUN
admet-1465	319	13	.	.	PUNCT
admet-1465	320	1	dissolution	dissolution	PROPN
admet-1465	320	2	technologies	technology	NOUN
admet-1465	320	3	26(2	26(2	NUM
admet-1465	320	4	)	)	PUNCT
admet-1465	320	5	(	(	PUNCT
admet-1465	320	6	2019	2019	NUM
admet-1465	320	7	)	)	PUNCT
admet-1465	320	8	40	40	NUM
admet-1465	320	9	-	-	SYM
admet-1465	320	10	46	46	NUM
admet-1465	320	11	.	.	PUNCT
admet-1465	321	1	https://doi.org/doi.org/10.14227/dt260219p40	https://doi.org/doi.org/10.14227/dt260219p40	PROPN
admet-1465	322	1	[	[	X
admet-1465	322	2	22	22	NUM
admet-1465	322	3	]	]	PUNCT
admet-1465	322	4	m.	m.	NOUN
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admet-1465	322	9	,	,	PUNCT
admet-1465	322	10	j.	j.	PROPN
admet-1465	322	11	østergaard	østergaard	PROPN
admet-1465	322	12	,	,	PUNCT
admet-1465	322	13	h.	h.	PROPN
admet-1465	322	14	jensen	jensen	PROPN
admet-1465	322	15	,	,	PUNCT
admet-1465	322	16	s.	s.	PROPN
admet-1465	322	17	weng	weng	PROPN
admet-1465	322	18	larsen	larsen	PROPN
admet-1465	322	19	.	.	PUNCT
admet-1465	323	1	in	in	ADP
admet-1465	323	2	vitro	vitro	X
admet-1465	323	3	release	release	NOUN
admet-1465	323	4	from	from	ADP
admet-1465	323	5	oil	oil	NOUN
admet-1465	323	6	injectables	injectable	NOUN
admet-1465	323	7	for	for	ADP
admet-1465	323	8	intra	intra	ADJ
admet-1465	323	9	-	-	ADJ
admet-1465	323	10	articular	articular	ADJ
admet-1465	323	11	administration	administration	NOUN
admet-1465	323	12	:	:	PUNCT
admet-1465	323	13	importance	importance	NOUN
admet-1465	323	14	of	of	ADP
admet-1465	323	15	interfacial	interfacial	ADJ
admet-1465	323	16	area	area	NOUN
admet-1465	323	17	,	,	PUNCT
admet-1465	323	18	diffusivity	diffusivity	NOUN
admet-1465	323	19	and	and	CCONJ
admet-1465	323	20	partitioning	partitioning	NOUN
admet-1465	323	21	.	.	PUNCT
admet-1465	324	1	european	european	PROPN
admet-1465	324	2	journal	journal	PROPN
admet-1465	324	3	of	of	ADP
admet-1465	324	4	pharmaceutical	pharmaceutical	PROPN
admet-1465	324	5	sciences	science	NOUN
admet-1465	324	6	45(3	45(3	NUM
admet-1465	324	7	)	)	PUNCT
admet-1465	324	8	(	(	PUNCT
admet-1465	324	9	2012	2012	NUM
admet-1465	324	10	)	)	PUNCT
admet-1465	324	11	351	351	NUM
admet-1465	324	12	-	-	SYM
admet-1465	324	13	357	357	NUM
admet-1465	324	14	.	.	PUNCT
admet-1465	325	1	https://doi.org/10.1016/j.ejps.2011.12.006	https://doi.org/10.1016/j.ejps.2011.12.006	PROPN
admet-1465	325	2	[	[	X
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admet-1465	325	4	]	]	PUNCT
admet-1465	325	5	b.	b.	PROPN
admet-1465	325	6	t.	t.	PROPN
admet-1465	325	7	pedersen	pedersen	PROPN
admet-1465	325	8	,	,	PUNCT
admet-1465	325	9	s.	s.	PROPN
admet-1465	325	10	weng	weng	PROPN
admet-1465	325	11	larsen	larsen	PROPN
admet-1465	325	12	,	,	PUNCT
admet-1465	325	13	j.	j.	PROPN
admet-1465	325	14	østergaard	østergaard	PROPN
admet-1465	325	15	,	,	PUNCT
admet-1465	325	16	c.	c.	PROPN
admet-1465	325	17	larsen	larsen	PROPN
admet-1465	325	18	.	.	PUNCT
admet-1465	326	1	in	in	ADP
admet-1465	326	2	vitro	vitro	X
admet-1465	326	3	assessment	assessment	NOUN
admet-1465	326	4	of	of	ADP
admet-1465	326	5	lidocaine	lidocaine	NOUN
admet-1465	326	6	release	release	NOUN
admet-1465	326	7	from	from	ADP
admet-1465	326	8	aqueous	aqueous	ADJ
admet-1465	326	9	and	and	CCONJ
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admet-1465	326	11	solutions	solution	NOUN
admet-1465	326	12	and	and	CCONJ
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admet-1465	326	14	preformed	preformed	ADJ
admet-1465	326	15	and	and	CCONJ
admet-1465	326	16	in	in	ADP
admet-1465	326	17	situ	situ	NOUN
admet-1465	326	18	formed	form	VERB
admet-1465	326	19	aqueous	aqueous	ADJ
admet-1465	326	20	and	and	CCONJ
admet-1465	326	21	oil	oil	NOUN
admet-1465	326	22	suspensions	suspension	NOUN
admet-1465	326	23	.	.	PUNCT
admet-1465	327	1	parenteral	parenteral	ADJ
admet-1465	327	2	depots	depot	NOUN
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admet-1465	327	4	intra	intra	ADJ
admet-1465	327	5	-	-	ADJ
admet-1465	327	6	articular	articular	ADJ
admet-1465	327	7	administration	administration	NOUN
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admet-1465	328	1	drug	drug	NOUN
admet-1465	328	2	delivery	delivery	NOUN
admet-1465	328	3	15(1	15(1	NUM
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admet-1465	328	5	(	(	PUNCT
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admet-1465	328	7	)	)	PUNCT
admet-1465	329	1	23	23	NUM
admet-1465	329	2	-	-	SYM
admet-1465	329	3	30	30	NUM
admet-1465	329	4	.	.	PUNCT
admet-1465	330	1	https://doi.org/10.1080/10717540701828657	https://doi.org/10.1080/10717540701828657	PRON
admet-1465	331	1	[	[	X
admet-1465	331	2	24	24	NUM
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admet-1465	331	4	r.	r.	PROPN
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admet-1465	331	9	schot	schot	NOUN
admet-1465	331	10	,	,	PUNCT
admet-1465	331	11	h.	h.	PROPN
admet-1465	331	12	vromans	vromans	PROPN
admet-1465	331	13	.	.	PUNCT
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admet-1465	332	4	drug	drug	NOUN
admet-1465	332	5	absorption	absorption	NOUN
admet-1465	332	6	from	from	ADP
admet-1465	332	7	a	a	DET
admet-1465	332	8	parenteral	parenteral	ADJ
admet-1465	332	9	oil	oil	NOUN
admet-1465	332	10	depot	depot	NOUN
admet-1465	332	11	.	.	PUNCT
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admet-1465	333	5	sciences	science	NOUN
admet-1465	333	6	83	83	NUM
admet-1465	333	7	(	(	PUNCT
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admet-1465	333	9	)	)	PUNCT
admet-1465	333	10	19	19	NUM
admet-1465	333	11	-	-	SYM
admet-1465	333	12	27	27	NUM
admet-1465	333	13	.	.	PUNCT
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admet-1465	335	28	https://pubchem.ncbi.nlm.nih.gov/compound/dexamethasone	https://pubchem.ncbi.nlm.nih.gov/compound/dexamethasone	PROPN
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