id	sid	tid	token	lemma	pos
admet-1474	1	1	pharmaceutical	pharmaceutical	NOUN
admet-1474	1	2	and	and	CCONJ
admet-1474	1	3	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	1	4	evaluation	evaluation	NOUN
admet-1474	1	5	of	of	ADP
admet-1474	1	6	a	a	DET
admet-1474	1	7	newly	newly	ADV
admet-1474	1	8	formulated	formulate	VERB
admet-1474	1	9	multiparticulate	multiparticulate	ADJ
admet-1474	1	10	matrix	matrix	NOUN
admet-1474	1	11	of	of	ADP
admet-1474	1	12	levodopa	levodopa	NOUN
admet-1474	1	13	and	and	CCONJ
admet-1474	1	14	carbidopa	carbidopa	ADJ
admet-1474	1	15	doi	doi	NOUN
admet-1474	1	16	:	:	PUNCT
admet-1474	1	17	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	1	18	97	97	NUM
admet-1474	1	19	admet	admet	PROPN
admet-1474	1	20	&	&	CCONJ
admet-1474	1	21	dmpk	dmpk	PROPN
admet-1474	1	22	11(1	11(1	NUM
admet-1474	1	23	)	)	PUNCT
admet-1474	1	24	(	(	PUNCT
admet-1474	1	25	2023	2023	NUM
admet-1474	1	26	)	)	PUNCT
admet-1474	1	27	97	97	NUM
admet-1474	1	28	-	-	SYM
admet-1474	1	29	115	115	NUM
admet-1474	1	30	;	;	PUNCT
admet-1474	1	31	doi	doi	NOUN
admet-1474	1	32	:	:	PUNCT
admet-1474	1	33	https://doi.org/10.5599/admet.1474	https://doi.org/10.5599/admet.1474	ADJ
admet-1474	1	34	open	open	ADJ
admet-1474	1	35	access	access	NOUN
admet-1474	1	36	:	:	PUNCT
admet-1474	1	37	issn	issn	PROPN
admet-1474	1	38	:	:	PUNCT
admet-1474	1	39	1848	1848	NUM
admet-1474	1	40	-	-	SYM
admet-1474	1	41	7718	7718	NUM
admet-1474	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-1474	1	43	original	original	ADJ
admet-1474	1	44	scientific	scientific	ADJ
admet-1474	1	45	paper	paper	NOUN
admet-1474	1	46	pharmaceutical	pharmaceutical	NOUN
admet-1474	1	47	and	and	CCONJ
admet-1474	1	48	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	1	49	evaluation	evaluation	NOUN
admet-1474	1	50	of	of	ADP
admet-1474	1	51	a	a	DET
admet-1474	1	52	newly	newly	ADV
admet-1474	1	53	formulated	formulate	VERB
admet-1474	1	54	multiparticulate	multiparticulate	ADJ
admet-1474	1	55	matrix	matrix	NOUN
admet-1474	1	56	of	of	ADP
admet-1474	1	57	levodopa	levodopa	NOUN
admet-1474	1	58	and	and	CCONJ
admet-1474	1	59	carbidopa	carbidopa	PROPN
admet-1474	1	60	emelia	emelia	PROPN
admet-1474	1	61	priscilla	priscilla	PROPN
admet-1474	1	62	imbeah,1	imbeah,1	PROPN
admet-1474	1	63			PROPN
admet-1474	1	64	ofosua	ofosua	NOUN
admet-1474	1	65	adi	adi	NOUN
admet-1474	1	66	-	-	PUNCT
admet-1474	1	67	dako,2	dako,2	NOUN
admet-1474	1	68	*	*	PUNCT
admet-1474	1	69	benoit	benoit	NOUN
admet-1474	1	70	banga	banga	PROPN
admet-1474	1	71	n’guessan,3	n’guessan,3	PROPN
admet-1474	1	72	kennedy	kennedy	PROPN
admet-1474	1	73	kwami	kwami	PROPN
admet-1474	1	74	edem	edem	PROPN
admet-1474	1	75	kukuia,1	kukuia,1	PROPN
admet-1474	1	76	benedicta	benedicta	PROPN
admet-1474	2	1	obenewaa	obenewaa	PROPN
admet-1474	2	2	dankyi,1	dankyi,1	NOUN
admet-1474	2	3	ismaila	ismaila	PRON
admet-1474	2	4	adams,1	adams,1	ADJ
admet-1474	2	5	ebenezer	ebenezer	PROPN
admet-1474	2	6	ofori	ofori	X
admet-1474	2	7	-	-	PUNCT
admet-1474	2	8	attah,4	attah,4	NOUN
admet-1474	2	9	regina	regina	PROPN
admet-1474	2	10	appiah	appiah	PROPN
admet-1474	2	11	-	-	PUNCT
admet-1474	2	12	opong,4	opong,4	NOUN
admet-1474	2	13	seth	seth	PROPN
admet-1474	2	14	kwabena	kwabena	PROPN
admet-1474	2	15	amponsah1	amponsah1	PROPN
admet-1474	2	16	1	1	NUM
admet-1474	2	17	department	department	PROPN
admet-1474	2	18	of	of	ADP
admet-1474	2	19	medical	medical	ADJ
admet-1474	2	20	pharmacology	pharmacology	NOUN
admet-1474	2	21	,	,	PUNCT
admet-1474	2	22	university	university	PROPN
admet-1474	2	23	of	of	ADP
admet-1474	2	24	ghana	ghana	PROPN
admet-1474	2	25	medical	medical	PROPN
admet-1474	2	26	school	school	PROPN
admet-1474	2	27	,	,	PUNCT
admet-1474	2	28	accra	accra	PROPN
admet-1474	2	29	,	,	PUNCT
admet-1474	2	30	ghana	ghana	PROPN
admet-1474	2	31	2	2	NUM
admet-1474	2	32	department	department	NOUN
admet-1474	2	33	of	of	ADP
admet-1474	2	34	pharmaceutics	pharmaceutic	NOUN
admet-1474	2	35	and	and	CCONJ
admet-1474	2	36	microbiology	microbiology	NOUN
admet-1474	2	37	,	,	PUNCT
admet-1474	2	38	school	school	NOUN
admet-1474	2	39	of	of	ADP
admet-1474	2	40	pharmacy	pharmacy	NOUN
admet-1474	2	41	,	,	PUNCT
admet-1474	2	42	university	university	PROPN
admet-1474	2	43	of	of	ADP
admet-1474	2	44	ghana	ghana	PROPN
admet-1474	2	45	,	,	PUNCT
admet-1474	2	46	accra	accra	PROPN
admet-1474	2	47	,	,	PUNCT
admet-1474	2	48	ghana	ghana	PROPN
admet-1474	2	49	3	3	NUM
admet-1474	2	50	department	department	PROPN
admet-1474	2	51	of	of	ADP
admet-1474	2	52	pharmacology	pharmacology	NOUN
admet-1474	2	53	and	and	CCONJ
admet-1474	2	54	toxicology	toxicology	NOUN
admet-1474	2	55	,	,	PUNCT
admet-1474	2	56	school	school	NOUN
admet-1474	2	57	of	of	ADP
admet-1474	2	58	pharmacy	pharmacy	NOUN
admet-1474	2	59	,	,	PUNCT
admet-1474	2	60	university	university	PROPN
admet-1474	2	61	of	of	ADP
admet-1474	2	62	ghana	ghana	PROPN
admet-1474	2	63	,	,	PUNCT
admet-1474	2	64	accra	accra	PROPN
admet-1474	2	65	,	,	PUNCT
admet-1474	2	66	ghana	ghana	PROPN
admet-1474	2	67	4	4	NUM
admet-1474	2	68	department	department	NOUN
admet-1474	2	69	of	of	ADP
admet-1474	2	70	clinical	clinical	ADJ
admet-1474	2	71	pathology	pathology	NOUN
admet-1474	2	72	,	,	PUNCT
admet-1474	2	73	noguchi	noguchi	PROPN
admet-1474	2	74	memorial	memorial	PROPN
admet-1474	2	75	institute	institute	PROPN
admet-1474	2	76	for	for	ADP
admet-1474	2	77	medical	medical	ADJ
admet-1474	2	78	research	research	NOUN
admet-1474	2	79	,	,	PUNCT
admet-1474	2	80	university	university	PROPN
admet-1474	2	81	of	of	ADP
admet-1474	2	82	ghana	ghana	PROPN
admet-1474	2	83	,	,	PUNCT
admet-1474	2	84	accra	accra	PROPN
admet-1474	2	85	,	,	PUNCT
admet-1474	2	86	ghana	ghana	PROPN
admet-1474	2	87	*	*	PUNCT
admet-1474	2	88	corresponding	correspond	VERB
admet-1474	2	89	author	author	NOUN
admet-1474	2	90	:	:	PUNCT
admet-1474	2	91	e	e	NOUN
admet-1474	2	92	-	-	NOUN
admet-1474	2	93	mail	mail	NOUN
admet-1474	2	94	:	:	PUNCT
admet-1474	2	95	oadi-dako@ug.edu.gh	oadi-dako@ug.edu.gh	NOUN
admet-1474	2	96	;	;	PUNCT
admet-1474	2	97	tel	tel	PROPN
admet-1474	2	98	.	.	PUNCT
admet-1474	2	99	:	:	PUNCT
admet-1474	3	1	+233	+233	NUM
admet-1474	3	2	-	-	SYM
admet-1474	3	3	248454868	248454868	NUM
admet-1474	3	4	;	;	PUNCT
admet-1474	3	5			NUM
admet-1474	3	6	co	co	VERB
admet-1474	3	7	-	-	ADJ
admet-1474	3	8	first	first	ADJ
admet-1474	3	9	authors	author	NOUN
admet-1474	3	10	:	:	PUNCT
admet-1474	3	11	emelia	emelia	PROPN
admet-1474	3	12	p.	p.	PROPN
admet-1474	3	13	imbeah	imbeah	PROPN
admet-1474	3	14	and	and	CCONJ
admet-1474	3	15	seth	seth	PROPN
admet-1474	3	16	k.	k.	PROPN
admet-1474	3	17	amponsah	amponsah	PROPN
admet-1474	3	18	received	receive	VERB
admet-1474	3	19	:	:	PUNCT
admet-1474	3	20	august	august	PROPN
admet-1474	3	21	01	01	NUM
admet-1474	3	22	,	,	PUNCT
admet-1474	3	23	2022	2022	NUM
admet-1474	3	24	;	;	PUNCT
admet-1474	3	25	revised	revise	VERB
admet-1474	3	26	:	:	PUNCT
admet-1474	3	27	october	october	PROPN
admet-1474	3	28	10	10	NUM
admet-1474	3	29	,	,	PUNCT
admet-1474	3	30	2022	2022	NUM
admet-1474	3	31	;	;	PUNCT
admet-1474	3	32	published	publish	VERB
admet-1474	3	33	:	:	PUNCT
admet-1474	3	34	october	october	PROPN
admet-1474	3	35	15	15	NUM
admet-1474	3	36	,	,	PUNCT
admet-1474	3	37	2022	2022	NUM
admet-1474	3	38	abstract	abstract	ADJ
admet-1474	3	39	levodopa	levodopa	NOUN
admet-1474	3	40	is	be	AUX
admet-1474	3	41	routinely	routinely	ADV
admet-1474	3	42	co	co	VERB
admet-1474	3	43	-	-	VERB
admet-1474	3	44	administered	administer	VERB
admet-1474	3	45	with	with	ADP
admet-1474	3	46	carbidopa	carbidopa	NOUN
admet-1474	3	47	in	in	ADP
admet-1474	3	48	the	the	DET
admet-1474	3	49	management	management	NOUN
admet-1474	3	50	of	of	ADP
admet-1474	3	51	parkinson	parkinson	NOUN
admet-1474	3	52	’s	’s	PART
admet-1474	3	53	disease	disease	NOUN
admet-1474	3	54	.	.	PUNCT
admet-1474	4	1	although	although	SCONJ
admet-1474	4	2	the	the	DET
admet-1474	4	3	aforementioned	aforementioned	ADJ
admet-1474	4	4	combination	combination	NOUN
admet-1474	4	5	therapy	therapy	NOUN
admet-1474	4	6	is	be	AUX
admet-1474	4	7	effective	effective	ADJ
admet-1474	4	8	,	,	PUNCT
admet-1474	4	9	there	there	PRON
admet-1474	4	10	may	may	AUX
admet-1474	4	11	be	be	AUX
admet-1474	4	12	fluctuating	fluctuate	VERB
admet-1474	4	13	plasma	plasma	NOUN
admet-1474	4	14	levels	level	NOUN
admet-1474	4	15	of	of	ADP
admet-1474	4	16	levodopa	levodopa	NOUN
admet-1474	4	17	after	after	ADP
admet-1474	4	18	oral	oral	ADJ
admet-1474	4	19	administration	administration	NOUN
admet-1474	4	20	.	.	PUNCT
admet-1474	5	1	we	we	PRON
admet-1474	5	2	formulated	formulate	VERB
admet-1474	5	3	and	and	CCONJ
admet-1474	5	4	evaluated	evaluate	VERB
admet-1474	5	5	the	the	DET
admet-1474	5	6	kinetic	kinetic	ADJ
admet-1474	5	7	characteristics	characteristic	NOUN
admet-1474	5	8	of	of	ADP
admet-1474	5	9	the	the	DET
admet-1474	5	10	chitosan	chitosan	NOUN
admet-1474	5	11	-	-	PUNCT
admet-1474	5	12	pectinbased	pectinbase	VERB
admet-1474	5	13	multiparticulate	multiparticulate	ADJ
admet-1474	5	14	matrix	matrix	NOUN
admet-1474	5	15	of	of	ADP
admet-1474	5	16	levodopa	levodopa	NOUN
admet-1474	5	17	and	and	CCONJ
admet-1474	5	18	carbidopa	carbidopa	NOUN
admet-1474	5	19	.	.	PUNCT
admet-1474	6	1	pectin	pectin	PROPN
admet-1474	6	2	was	be	AUX
admet-1474	6	3	extracted	extract	VERB
admet-1474	6	4	from	from	ADP
admet-1474	6	5	the	the	DET
admet-1474	6	6	cocoa	cocoa	NOUN
admet-1474	6	7	husk	husk	NOUN
admet-1474	6	8	,	,	PUNCT
admet-1474	6	9	and	and	CCONJ
admet-1474	6	10	the	the	DET
admet-1474	6	11	chitosan	chitosan	NOUN
admet-1474	6	12	-	-	PUNCT
admet-1474	6	13	pectin	pectin	NOUN
admet-1474	6	14	-	-	PUNCT
admet-1474	6	15	based	base	VERB
admet-1474	6	16	matrix	matrix	NOUN
admet-1474	6	17	was	be	AUX
admet-1474	6	18	prepared	prepare	VERB
admet-1474	6	19	by	by	ADP
admet-1474	6	20	wet	wet	ADJ
admet-1474	6	21	granulation	granulation	NOUN
admet-1474	6	22	.	.	PUNCT
admet-1474	7	1	formulations	formulation	NOUN
admet-1474	7	2	were	be	AUX
admet-1474	7	3	evaluated	evaluate	VERB
admet-1474	7	4	for	for	ADP
admet-1474	7	5	drugexcipient	drugexcipient	NOUN
admet-1474	7	6	compatibility	compatibility	NOUN
admet-1474	7	7	,	,	PUNCT
admet-1474	7	8	drug	drug	NOUN
admet-1474	7	9	content	content	NOUN
admet-1474	7	10	,	,	PUNCT
admet-1474	7	11	precompression	precompression	NOUN
admet-1474	7	12	properties	property	NOUN
admet-1474	7	13	and	and	CCONJ
admet-1474	7	14	in	in	ADP
admet-1474	7	15	vitro	vitro	X
admet-1474	7	16	release	release	NOUN
admet-1474	7	17	.	.	PUNCT
admet-1474	8	1	for	for	ADP
admet-1474	8	2	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	8	3	evaluation	evaluation	NOUN
admet-1474	8	4	,	,	PUNCT
admet-1474	8	5	rats	rat	NOUN
admet-1474	8	6	were	be	AUX
admet-1474	8	7	put	put	VERB
admet-1474	8	8	into	into	ADP
admet-1474	8	9	groups	group	NOUN
admet-1474	8	10	and	and	CCONJ
admet-1474	8	11	administered	administer	VERB
admet-1474	8	12	either	either	CCONJ
admet-1474	8	13	chitosan	chitosan	NOUN
admet-1474	8	14	-	-	PUNCT
admet-1474	8	15	pectin	pectin	NOUN
admet-1474	8	16	based	base	VERB
admet-1474	8	17	matrix	matrix	NOUN
admet-1474	8	18	of	of	ADP
admet-1474	8	19	levodopa	levodopa	NOUN
admet-1474	8	20	/	/	SYM
admet-1474	8	21	carbidopa	carbidopa	NOUN
admet-1474	8	22	,	,	PUNCT
admet-1474	8	23	sinemet	sinemet	PROPN
admet-1474	8	24	®	®	NOUN
admet-1474	8	25	cr	cr	NOUN
admet-1474	8	26	or	or	CCONJ
admet-1474	8	27	levodopa	levodopa	NOUN
admet-1474	8	28	/	/	SYM
admet-1474	8	29	carbidopa	carbidopa	NOUN
admet-1474	8	30	immediate	immediate	ADJ
admet-1474	8	31	release	release	NOUN
admet-1474	8	32	powder	powder	NOUN
admet-1474	8	33	.	.	PUNCT
admet-1474	9	1	rats	rat	NOUN
admet-1474	9	2	were	be	AUX
admet-1474	9	3	administered	administer	VERB
admet-1474	9	4	the	the	DET
admet-1474	9	5	different	different	ADJ
admet-1474	9	6	formulations	formulation	NOUN
admet-1474	9	7	of	of	ADP
admet-1474	9	8	levodopa	levodopa	NOUN
admet-1474	9	9	/	/	SYM
admet-1474	9	10	carbidopa	carbidopa	NOUN
admet-1474	9	11	(	(	PUNCT
admet-1474	9	12	20/5	20/5	NUM
admet-1474	9	13	mg	mg	NUM
admet-1474	9	14	/	/	SYM
admet-1474	9	15	kg	kg	NOUN
admet-1474	9	16	)	)	PUNCT
admet-1474	9	17	per	per	ADP
admet-1474	9	18	os	os	NOUN
admet-1474	9	19	every	every	DET
admet-1474	9	20	12	12	NUM
admet-1474	9	21	hours	hour	NOUN
admet-1474	9	22	.	.	PUNCT
admet-1474	10	1	the	the	DET
admet-1474	10	2	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	10	3	parameters	parameter	NOUN
admet-1474	10	4	of	of	ADP
admet-1474	10	5	levodopa	levodopa	NOUN
admet-1474	10	6	were	be	AUX
admet-1474	10	7	estimated	estimate	VERB
admet-1474	10	8	for	for	ADP
admet-1474	10	9	the	the	DET
admet-1474	10	10	various	various	ADJ
admet-1474	10	11	treatment	treatment	NOUN
admet-1474	10	12	groups	group	NOUN
admet-1474	10	13	.	.	PUNCT
admet-1474	11	1	the	the	DET
admet-1474	11	2	percentage	percentage	NOUN
admet-1474	11	3	content	content	NOUN
admet-1474	11	4	of	of	ADP
admet-1474	11	5	levodopa	levodopa	NOUN
admet-1474	11	6	and	and	CCONJ
admet-1474	11	7	carbidopa	carbidopa	NOUN
admet-1474	11	8	in	in	ADP
admet-1474	11	9	the	the	DET
admet-1474	11	10	various	various	ADJ
admet-1474	11	11	formulations	formulation	NOUN
admet-1474	11	12	was	be	AUX
admet-1474	11	13	within	within	ADP
admet-1474	11	14	the	the	DET
admet-1474	11	15	acceptance	acceptance	NOUN
admet-1474	11	16	criteria	criterion	NOUN
admet-1474	11	17	.	.	PUNCT
admet-1474	12	1	the	the	DET
admet-1474	12	2	auc0	auc0	PROPN
admet-1474	12	3	-	-	PUNCT
admet-1474	12	4	24	24	NUM
admet-1474	12	5	for	for	ADP
admet-1474	12	6	levodopa	levodopa	NOUN
admet-1474	12	7	/	/	SYM
admet-1474	12	8	carbidopa	carbidopa	NOUN
admet-1474	12	9	multiparticulate	multiparticulate	NOUN
admet-1474	12	10	matrix	matrix	NOUN
admet-1474	12	11	(	(	PUNCT
admet-1474	12	12	formulation	formulation	NOUN
admet-1474	12	13	3	3	NUM
admet-1474	12	14	:	:	PUNCT
admet-1474	12	15	484.98	484.98	NUM
admet-1474	12	16	±	±	NOUN
admet-1474	12	17	18.70	18.70	NUM
admet-1474	12	18	µg.hr/ml	µg.hr/ml	PROPN
admet-1474	12	19	)	)	PUNCT
admet-1474	12	20	;	;	PUNCT
admet-1474	12	21	formulation	formulation	NOUN
admet-1474	12	22	4	4	NUM
admet-1474	12	23	:	:	PUNCT
admet-1474	12	24	535.60	535.60	NUM
admet-1474	12	25	±	±	NOUN
admet-1474	12	26	33.04	33.04	NUM
admet-1474	12	27	µg.hr/ml	µg.hr/ml	ADJ
admet-1474	12	28	)	)	PUNCT
admet-1474	12	29	,	,	PUNCT
admet-1474	12	30	and	and	CCONJ
admet-1474	12	31	cmax	cmax	NOUN
admet-1474	12	32	(	(	PUNCT
admet-1474	12	33	formulation	formulation	NOUN
admet-1474	12	34	3	3	NUM
admet-1474	12	35	:	:	PUNCT
admet-1474	12	36	36.28	36.28	NUM
admet-1474	12	37	±	±	NUM
admet-1474	12	38	1.52	1.52	NUM
admet-1474	12	39	μg	μg	NOUN
admet-1474	12	40	/	/	SYM
admet-1474	12	41	ml	ml	PROPN
admet-1474	12	42	;	;	PUNCT
admet-1474	12	43	formulation	formulation	NOUN
admet-1474	12	44	4	4	NUM
admet-1474	12	45	:	:	PUNCT
admet-1474	12	46	34.80	34.80	NUM
admet-1474	12	47	±	±	NUM
admet-1474	12	48	2.19	2.19	NUM
admet-1474	12	49	μg	μg	NOUN
admet-1474	12	50	/	/	SYM
admet-1474	12	51	ml	ml	NOUN
admet-1474	12	52	)	)	PUNCT
admet-1474	12	53	were	be	AUX
admet-1474	12	54	higher	high	ADJ
admet-1474	12	55	than	than	SCONJ
admet-1474	12	56	sinemet	sinemet	PROPN
admet-1474	12	57	®	®	PROPN
admet-1474	12	58	cr	cr	PROPN
admet-1474	12	59	(	(	PUNCT
admet-1474	12	60	auc0	auc0	PROPN
admet-1474	12	61	-	-	PUNCT
admet-1474	12	62	24	24	NUM
admet-1474	12	63	262.84	262.84	NUM
admet-1474	12	64	±	±	NUM
admet-1474	12	65	16.73	16.73	NUM
admet-1474	12	66	µg.hr/ml	µg.hr/ml	VERB
admet-1474	12	67	and	and	CCONJ
admet-1474	12	68	cmax	cmax	VERB
admet-1474	12	69	30.62	30.62	NUM
admet-1474	12	70	±	±	NUM
admet-1474	12	71	3.37	3.37	NUM
admet-1474	12	72	μg	μg	NOUN
admet-1474	12	73	/	/	SYM
admet-1474	12	74	ml	ml	NOUN
admet-1474	12	75	)	)	PUNCT
admet-1474	12	76	.	.	PUNCT
admet-1474	13	1	the	the	DET
admet-1474	13	2	t1/2	t1/2	NOUN
admet-1474	13	3	of	of	ADP
admet-1474	13	4	the	the	DET
admet-1474	13	5	new	new	ADJ
admet-1474	13	6	formulation	formulation	NOUN
admet-1474	13	7	was	be	AUX
admet-1474	13	8	longer	long	ADV
admet-1474	13	9	compared	compare	VERB
admet-1474	13	10	to	to	ADP
admet-1474	13	11	sinemet	sinemet	PROPN
admet-1474	13	12	®	®	PROPN
admet-1474	13	13	cr	cr	PROPN
admet-1474	13	14	.	.	PUNCT
admet-1474	14	1	©	©	PROPN
admet-1474	14	2	2022	2022	NUM
admet-1474	14	3	by	by	ADP
admet-1474	14	4	the	the	DET
admet-1474	14	5	authors	author	NOUN
admet-1474	14	6	.	.	PUNCT
admet-1474	15	1	this	this	DET
admet-1474	15	2	article	article	NOUN
admet-1474	15	3	is	be	AUX
admet-1474	15	4	an	an	DET
admet-1474	15	5	open	open	ADJ
admet-1474	15	6	-	-	PUNCT
admet-1474	15	7	access	access	NOUN
admet-1474	15	8	article	article	NOUN
admet-1474	15	9	distributed	distribute	VERB
admet-1474	15	10	under	under	ADP
admet-1474	15	11	the	the	DET
admet-1474	15	12	terms	term	NOUN
admet-1474	15	13	and	and	CCONJ
admet-1474	15	14	conditions	condition	NOUN
admet-1474	15	15	of	of	ADP
admet-1474	15	16	the	the	DET
admet-1474	15	17	creative	creative	ADJ
admet-1474	15	18	commons	common	NOUN
admet-1474	15	19	attribution	attribution	NOUN
admet-1474	15	20	license	license	NOUN
admet-1474	15	21	(	(	PUNCT
admet-1474	15	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1474	15	23	)	)	PUNCT
admet-1474	15	24	.	.	PUNCT
admet-1474	16	1	keywords	keyword	VERB
admet-1474	16	2	formulation	formulation	NOUN
admet-1474	16	3	;	;	PUNCT
admet-1474	16	4	parkinson	parkinson	NOUN
admet-1474	16	5	’s	’s	PART
admet-1474	16	6	disease	disease	NOUN
admet-1474	16	7	;	;	PUNCT
admet-1474	16	8	management	management	NOUN
admet-1474	16	9	;	;	PUNCT
admet-1474	16	10	pectin	pectin	NOUN
admet-1474	16	11	;	;	PUNCT
admet-1474	16	12	pharmacokinetics	pharmacokinetic	NOUN
admet-1474	16	13	;	;	PUNCT
admet-1474	16	14	chitosan	chitosan	NOUN
admet-1474	16	15	introduction	introduction	NOUN
admet-1474	16	16	parkinson	parkinson	NOUN
admet-1474	16	17	’s	’s	PART
admet-1474	16	18	disease	disease	NOUN
admet-1474	16	19	(	(	PUNCT
admet-1474	16	20	pd	pd	NOUN
admet-1474	16	21	)	)	PUNCT
admet-1474	16	22	is	be	AUX
admet-1474	16	23	a	a	DET
admet-1474	16	24	debilitating	debilitate	VERB
admet-1474	16	25	disorder	disorder	NOUN
admet-1474	16	26	that	that	PRON
admet-1474	16	27	affects	affect	VERB
admet-1474	16	28	the	the	DET
admet-1474	16	29	skeletal	skeletal	ADJ
admet-1474	16	30	muscle	muscle	NOUN
admet-1474	16	31	system	system	NOUN
admet-1474	16	32	[	[	X
admet-1474	16	33	1	1	NUM
admet-1474	16	34	]	]	PUNCT
admet-1474	16	35	.	.	PUNCT
admet-1474	17	1	some	some	DET
admet-1474	17	2	cardinal	cardinal	ADJ
admet-1474	17	3	symptoms	symptom	NOUN
admet-1474	17	4	associated	associate	VERB
admet-1474	17	5	with	with	ADP
admet-1474	17	6	pd	pd	PROPN
admet-1474	17	7	include	include	VERB
admet-1474	17	8	muscle	muscle	NOUN
admet-1474	17	9	rigidity	rigidity	NOUN
admet-1474	17	10	,	,	PUNCT
admet-1474	17	11	slow	slow	ADJ
admet-1474	17	12	body	body	NOUN
admet-1474	17	13	movements	movement	NOUN
admet-1474	17	14	,	,	PUNCT
admet-1474	17	15	difficulty	difficulty	NOUN
admet-1474	17	16	standing	stand	VERB
admet-1474	17	17	and	and	CCONJ
admet-1474	17	18	tremor	tremor	NOUN
admet-1474	17	19	[	[	X
admet-1474	17	20	2	2	NUM
admet-1474	17	21	]	]	PUNCT
admet-1474	17	22	.	.	PUNCT
admet-1474	18	1	there	there	PRON
admet-1474	18	2	could	could	AUX
admet-1474	18	3	also	also	ADV
admet-1474	18	4	be	be	AUX
admet-1474	18	5	non	non	ADJ
admet-1474	18	6	-	-	ADJ
admet-1474	18	7	motor	motor	ADJ
admet-1474	18	8	symptoms	symptom	NOUN
admet-1474	18	9	associated	associate	VERB
admet-1474	18	10	with	with	ADP
admet-1474	18	11	pd	pd	PROPN
admet-1474	18	12	,	,	PUNCT
admet-1474	18	13	including	include	VERB
admet-1474	18	14	sensory	sensory	ADJ
admet-1474	18	15	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	NOUN
admet-1474	18	16	https://doi.org/10.5599/admet.1474	https://doi.org/10.5599/admet.1474	ADJ
admet-1474	18	17	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-1474	19	1	mailto:oadi-dako@ug.edu.gh	mailto:oadi-dako@ug.edu.gh	PROPN
admet-1474	19	2	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-1474	19	3	emelia	emelia	PROPN
admet-1474	19	4	priscilla	priscilla	PROPN
admet-1474	20	1	imbeah	imbeah	PROPN
admet-1474	20	2	et	et	PROPN
admet-1474	20	3	al	al	PROPN
admet-1474	20	4	.	.	PROPN
admet-1474	20	5	admet	admet	PROPN
admet-1474	20	6	&	&	CCONJ
admet-1474	20	7	dmpk	dmpk	PROPN
admet-1474	20	8	11(1	11(1	NUM
admet-1474	20	9	)	)	PUNCT
admet-1474	20	10	(	(	PUNCT
admet-1474	20	11	2023	2023	NUM
admet-1474	20	12	)	)	PUNCT
admet-1474	20	13	97	97	NUM
admet-1474	20	14	-	-	SYM
admet-1474	20	15	115	115	NUM
admet-1474	20	16	98	98	NUM
admet-1474	20	17	abnormalities	abnormality	NOUN
admet-1474	20	18	,	,	PUNCT
admet-1474	20	19	autonomic	autonomic	ADJ
admet-1474	20	20	dysfunction	dysfunction	NOUN
admet-1474	20	21	,	,	PUNCT
admet-1474	20	22	and	and	CCONJ
admet-1474	20	23	dementia	dementia	NOUN
admet-1474	20	24	.	.	PUNCT
admet-1474	21	1	estimates	estimate	NOUN
admet-1474	21	2	suggest	suggest	VERB
admet-1474	21	3	that	that	SCONJ
admet-1474	21	4	more	more	ADJ
admet-1474	21	5	than	than	ADP
admet-1474	21	6	6	6	NUM
admet-1474	21	7	million	million	NUM
admet-1474	21	8	people	people	NOUN
admet-1474	21	9	worldwide	worldwide	ADV
admet-1474	21	10	are	be	AUX
admet-1474	21	11	affected	affect	VERB
admet-1474	21	12	by	by	ADP
admet-1474	21	13	pd	pd	PROPN
admet-1474	22	1	[	[	X
admet-1474	22	2	3	3	NUM
admet-1474	22	3	,	,	PUNCT
admet-1474	22	4	4	4	NUM
admet-1474	22	5	]	]	PUNCT
admet-1474	22	6	.	.	PUNCT
admet-1474	23	1	a	a	DET
admet-1474	23	2	biological	biological	ADJ
admet-1474	23	3	precursor	precursor	NOUN
admet-1474	23	4	of	of	ADP
admet-1474	23	5	dopamine	dopamine	NOUN
admet-1474	23	6	,	,	PUNCT
admet-1474	23	7	levodopa	levodopa	NOUN
admet-1474	23	8	,	,	PUNCT
admet-1474	23	9	is	be	AUX
admet-1474	23	10	the	the	DET
admet-1474	23	11	current	current	ADJ
admet-1474	23	12	mainstay	mainstay	NOUN
admet-1474	23	13	in	in	ADP
admet-1474	23	14	the	the	DET
admet-1474	23	15	management	management	NOUN
admet-1474	23	16	of	of	ADP
admet-1474	23	17	pd	pd	PROPN
admet-1474	23	18	.	.	PROPN
admet-1474	24	1	when	when	SCONJ
admet-1474	24	2	levodopa	levodopa	NOUN
admet-1474	24	3	is	be	AUX
admet-1474	24	4	administered	administer	VERB
admet-1474	24	5	via	via	ADP
admet-1474	24	6	the	the	DET
admet-1474	24	7	oral	oral	ADJ
admet-1474	24	8	route	route	NOUN
admet-1474	24	9	,	,	PUNCT
admet-1474	24	10	it	it	PRON
admet-1474	24	11	is	be	AUX
admet-1474	24	12	absorbed	absorb	VERB
admet-1474	24	13	into	into	ADP
admet-1474	24	14	the	the	DET
admet-1474	24	15	circulation	circulation	NOUN
admet-1474	24	16	and	and	CCONJ
admet-1474	24	17	distributed	distribute	VERB
admet-1474	24	18	to	to	ADP
admet-1474	24	19	the	the	DET
admet-1474	24	20	brain	brain	NOUN
admet-1474	24	21	.	.	PUNCT
admet-1474	25	1	after	after	SCONJ
admet-1474	25	2	levodopa	levodopa	NOUN
admet-1474	25	3	crosses	cross	VERB
admet-1474	25	4	the	the	DET
admet-1474	25	5	blood	blood	NOUN
admet-1474	25	6	-	-	PUNCT
admet-1474	25	7	brain	brain	NOUN
admet-1474	25	8	barrier	barrier	NOUN
admet-1474	25	9	,	,	PUNCT
admet-1474	25	10	it	it	PRON
admet-1474	25	11	is	be	AUX
admet-1474	25	12	converted	convert	VERB
admet-1474	25	13	to	to	ADP
admet-1474	25	14	dopamine	dopamine	NOUN
admet-1474	25	15	,	,	PUNCT
admet-1474	25	16	a	a	DET
admet-1474	25	17	process	process	NOUN
admet-1474	25	18	catalyzed	catalyze	VERB
admet-1474	25	19	by	by	ADP
admet-1474	25	20	dopa	dopa	NOUN
admet-1474	25	21	decarboxylases	decarboxylase	NOUN
admet-1474	25	22	.	.	PUNCT
admet-1474	26	1	this	this	PRON
admet-1474	26	2	leads	lead	VERB
admet-1474	26	3	to	to	ADP
admet-1474	26	4	an	an	DET
admet-1474	26	5	increase	increase	NOUN
admet-1474	26	6	in	in	ADP
admet-1474	26	7	dopamine	dopamine	NOUN
admet-1474	26	8	levels	level	NOUN
admet-1474	26	9	in	in	ADP
admet-1474	26	10	the	the	DET
admet-1474	26	11	depleted	depleted	ADJ
admet-1474	26	12	striatum	striatum	NOUN
admet-1474	26	13	[	[	X
admet-1474	26	14	2	2	NUM
admet-1474	26	15	]	]	PUNCT
admet-1474	26	16	.	.	PUNCT
admet-1474	27	1	orally	orally	ADV
admet-1474	27	2	administered	administer	VERB
admet-1474	27	3	levodopa	levodopa	NOUN
admet-1474	27	4	exhibits	exhibit	VERB
admet-1474	27	5	low	low	ADJ
admet-1474	27	6	bioavailability	bioavailability	NOUN
admet-1474	27	7	(	(	PUNCT
admet-1474	27	8	about	about	ADV
admet-1474	27	9	30	30	NUM
admet-1474	27	10	%	%	NOUN
admet-1474	27	11	)	)	PUNCT
admet-1474	27	12	;	;	PUNCT
admet-1474	27	13	because	because	SCONJ
admet-1474	27	14	of	of	ADP
admet-1474	27	15	extensive	extensive	ADJ
admet-1474	27	16	metabolism	metabolism	NOUN
admet-1474	27	17	by	by	ADP
admet-1474	27	18	decarboxylases	decarboxylase	NOUN
admet-1474	27	19	in	in	ADP
admet-1474	27	20	peripheral	peripheral	ADJ
admet-1474	27	21	circulation	circulation	NOUN
admet-1474	27	22	[	[	X
admet-1474	27	23	5	5	NUM
admet-1474	27	24	]	]	PUNCT
admet-1474	27	25	.	.	PUNCT
admet-1474	28	1	furthermore	furthermore	ADV
admet-1474	28	2	,	,	PUNCT
admet-1474	28	3	the	the	DET
admet-1474	28	4	systemic	systemic	ADJ
admet-1474	28	5	conversion	conversion	NOUN
admet-1474	28	6	of	of	ADP
admet-1474	28	7	levodopa	levodopa	NOUN
admet-1474	28	8	to	to	ADP
admet-1474	28	9	dopamine	dopamine	NOUN
admet-1474	28	10	often	often	ADV
admet-1474	28	11	leads	lead	VERB
admet-1474	28	12	to	to	ADP
admet-1474	28	13	unwanted	unwanted	ADJ
admet-1474	28	14	side	side	NOUN
admet-1474	28	15	effects	effect	NOUN
admet-1474	28	16	[	[	X
admet-1474	28	17	6	6	NUM
admet-1474	28	18	]	]	PUNCT
admet-1474	28	19	.	.	PUNCT
admet-1474	29	1	to	to	PART
admet-1474	29	2	reduce	reduce	VERB
admet-1474	29	3	the	the	DET
admet-1474	29	4	metabolism	metabolism	NOUN
admet-1474	29	5	of	of	ADP
admet-1474	29	6	levodopa	levodopa	NOUN
admet-1474	29	7	in	in	ADP
admet-1474	29	8	the	the	DET
admet-1474	29	9	periphery	periphery	NOUN
admet-1474	29	10	,	,	PUNCT
admet-1474	29	11	it	it	PRON
admet-1474	29	12	is	be	AUX
admet-1474	29	13	routinely	routinely	ADV
admet-1474	29	14	co	co	VERB
admet-1474	29	15	-	-	VERB
admet-1474	29	16	administered	administer	VERB
admet-1474	29	17	with	with	ADP
admet-1474	29	18	dopa	dopa	NOUN
admet-1474	29	19	decarboxylase	decarboxylase	NOUN
admet-1474	29	20	inhibitors	inhibitor	NOUN
admet-1474	29	21	such	such	ADJ
admet-1474	29	22	as	as	ADP
admet-1474	29	23	carbidopa	carbidopa	NOUN
admet-1474	29	24	.	.	PUNCT
admet-1474	30	1	although	although	SCONJ
admet-1474	30	2	effective	effective	ADJ
admet-1474	30	3	,	,	PUNCT
admet-1474	30	4	a	a	DET
admet-1474	30	5	number	number	NOUN
admet-1474	30	6	of	of	ADP
admet-1474	30	7	patients	patient	NOUN
admet-1474	30	8	develop	develop	VERB
admet-1474	30	9	motor	motor	NOUN
admet-1474	30	10	complications	complication	NOUN
admet-1474	30	11	as	as	ADP
admet-1474	30	12	treatment	treatment	NOUN
admet-1474	30	13	progresses	progress	NOUN
admet-1474	30	14	with	with	ADP
admet-1474	30	15	levodopa	levodopa	NOUN
admet-1474	30	16	and	and	CCONJ
admet-1474	30	17	carbidopa	carbidopa	NOUN
admet-1474	30	18	[	[	X
admet-1474	30	19	6	6	NUM
admet-1474	30	20	]	]	PUNCT
admet-1474	30	21	.	.	PUNCT
admet-1474	31	1	reports	report	NOUN
admet-1474	31	2	suggest	suggest	VERB
admet-1474	31	3	that	that	SCONJ
admet-1474	31	4	these	these	DET
admet-1474	31	5	drawbacks	drawback	NOUN
admet-1474	31	6	result	result	VERB
admet-1474	31	7	from	from	ADP
admet-1474	31	8	fluctuations	fluctuation	NOUN
admet-1474	31	9	in	in	ADP
admet-1474	31	10	the	the	DET
admet-1474	31	11	plasma	plasma	NOUN
admet-1474	31	12	concentration	concentration	NOUN
admet-1474	31	13	of	of	ADP
admet-1474	31	14	levodopa	levodopa	NOUN
admet-1474	32	1	[	[	X
admet-1474	32	2	7	7	NUM
admet-1474	32	3	]	]	PUNCT
admet-1474	32	4	.	.	PUNCT
admet-1474	33	1	constant	constant	ADJ
admet-1474	33	2	dopamine	dopamine	NOUN
admet-1474	33	3	levels	level	NOUN
admet-1474	33	4	in	in	ADP
admet-1474	33	5	the	the	DET
admet-1474	33	6	central	central	ADJ
admet-1474	33	7	nervous	nervous	ADJ
admet-1474	33	8	system	system	NOUN
admet-1474	33	9	could	could	AUX
admet-1474	33	10	lower	lower	VERB
admet-1474	33	11	or	or	CCONJ
admet-1474	33	12	prevent	prevent	VERB
admet-1474	33	13	the	the	DET
admet-1474	33	14	emergence	emergence	NOUN
admet-1474	33	15	of	of	ADP
admet-1474	33	16	motor	motor	NOUN
admet-1474	33	17	fluctuations	fluctuation	NOUN
admet-1474	33	18	and	and	CCONJ
admet-1474	33	19	dyskinesia	dyskinesia	NOUN
admet-1474	33	20	in	in	ADP
admet-1474	33	21	pd	pd	PROPN
admet-1474	33	22	patients	patient	NOUN
admet-1474	33	23	.	.	PUNCT
admet-1474	34	1	therefore	therefore	ADV
admet-1474	34	2	,	,	PUNCT
admet-1474	34	3	a	a	DET
admet-1474	34	4	number	number	NOUN
admet-1474	34	5	of	of	ADP
admet-1474	34	6	studies	study	NOUN
admet-1474	34	7	have	have	AUX
admet-1474	34	8	focused	focus	VERB
admet-1474	34	9	on	on	ADP
admet-1474	34	10	the	the	DET
admet-1474	34	11	development	development	NOUN
admet-1474	34	12	of	of	ADP
admet-1474	34	13	improved	improved	ADJ
admet-1474	34	14	delivery	delivery	NOUN
admet-1474	34	15	systems	system	NOUN
admet-1474	34	16	for	for	ADP
admet-1474	34	17	levodopa	levodopa	NOUN
admet-1474	34	18	and	and	CCONJ
admet-1474	34	19	other	other	ADJ
admet-1474	34	20	antiparkinson	antiparkinson	NOUN
admet-1474	34	21	drugs	drug	NOUN
admet-1474	34	22	.	.	PUNCT
admet-1474	35	1	most	most	ADJ
admet-1474	35	2	of	of	ADP
admet-1474	35	3	these	these	DET
admet-1474	35	4	delivery	delivery	NOUN
admet-1474	35	5	systems	system	NOUN
admet-1474	35	6	aim	aim	VERB
admet-1474	35	7	to	to	PART
admet-1474	35	8	improve	improve	VERB
admet-1474	35	9	bioavailability	bioavailability	NOUN
admet-1474	35	10	and	and	CCONJ
admet-1474	35	11	minimize	minimize	VERB
admet-1474	35	12	unwanted	unwanted	ADJ
admet-1474	35	13	motor	motor	NOUN
admet-1474	35	14	complications	complication	NOUN
admet-1474	35	15	of	of	ADP
admet-1474	35	16	levodopa	levodopa	NOUN
admet-1474	35	17	[	[	X
admet-1474	35	18	8–10	8–10	NOUN
admet-1474	35	19	]	]	PUNCT
admet-1474	35	20	.	.	PUNCT
admet-1474	36	1	over	over	ADP
admet-1474	36	2	the	the	DET
admet-1474	36	3	last	last	ADJ
admet-1474	36	4	few	few	ADJ
admet-1474	36	5	decades	decade	NOUN
admet-1474	36	6	,	,	PUNCT
admet-1474	36	7	natural	natural	ADJ
admet-1474	36	8	and	and	CCONJ
admet-1474	36	9	biocompatible	biocompatible	ADJ
admet-1474	36	10	polymer	polymer	NOUN
admet-1474	36	11	matrices	matrix	NOUN
admet-1474	36	12	have	have	AUX
admet-1474	36	13	been	be	AUX
admet-1474	36	14	used	use	VERB
admet-1474	36	15	as	as	ADP
admet-1474	36	16	carriers	carrier	NOUN
admet-1474	36	17	for	for	ADP
admet-1474	36	18	sustained	sustained	ADJ
admet-1474	36	19	drug	drug	NOUN
admet-1474	36	20	release	release	NOUN
admet-1474	36	21	[	[	X
admet-1474	36	22	11,12	11,12	NUM
admet-1474	36	23	]	]	PUNCT
admet-1474	36	24	.	.	PUNCT
admet-1474	37	1	chitosan	chitosan	NOUN
admet-1474	37	2	and	and	CCONJ
admet-1474	37	3	pectin	pectin	NOUN
admet-1474	37	4	are	be	AUX
admet-1474	37	5	biopolymers	biopolymer	NOUN
admet-1474	37	6	that	that	PRON
admet-1474	37	7	are	be	AUX
admet-1474	37	8	readily	readily	ADV
admet-1474	37	9	available	available	ADJ
admet-1474	37	10	,	,	PUNCT
admet-1474	37	11	ecofriendly	ecofriendly	ADV
admet-1474	37	12	,	,	PUNCT
admet-1474	37	13	immunocompatible	immunocompatible	ADJ
admet-1474	37	14	,	,	PUNCT
admet-1474	37	15	and	and	CCONJ
admet-1474	37	16	non	non	ADJ
admet-1474	37	17	-	-	ADJ
admet-1474	37	18	toxic	toxic	ADJ
admet-1474	37	19	.	.	PUNCT
admet-1474	38	1	chitosan	chitosan	NOUN
admet-1474	38	2	and	and	CCONJ
admet-1474	38	3	pectin	pectin	NOUN
admet-1474	38	4	are	be	AUX
admet-1474	38	5	less	less	ADV
admet-1474	38	6	expensive	expensive	ADJ
admet-1474	38	7	compared	compare	VERB
admet-1474	38	8	to	to	ADP
admet-1474	38	9	synthetic	synthetic	ADJ
admet-1474	38	10	polymers	polymer	NOUN
admet-1474	38	11	such	such	ADJ
admet-1474	38	12	as	as	ADP
admet-1474	38	13	polylactic	polylactic	ADJ
admet-1474	38	14	acid	acid	NOUN
admet-1474	38	15	,	,	PUNCT
admet-1474	38	16	and	and	CCONJ
admet-1474	38	17	polyglycolic	polyglycolic	ADJ
admet-1474	38	18	acid	acid	NOUN
admet-1474	38	19	,	,	PUNCT
admet-1474	38	20	among	among	ADP
admet-1474	38	21	others	other	NOUN
admet-1474	38	22	.	.	PUNCT
admet-1474	39	1	cocoa	cocoa	NOUN
admet-1474	39	2	pod	pod	PROPN
admet-1474	39	3	husk	husk	PROPN
admet-1474	39	4	(	(	PUNCT
admet-1474	39	5	cph	cph	PROPN
admet-1474	39	6	)	)	PUNCT
admet-1474	39	7	pectin	pectin	NOUN
admet-1474	39	8	is	be	AUX
admet-1474	39	9	an	an	DET
admet-1474	39	10	anionic	anionic	ADJ
admet-1474	39	11	polysaccharide	polysaccharide	NOUN
admet-1474	39	12	often	often	ADV
admet-1474	39	13	used	use	VERB
admet-1474	39	14	as	as	ADP
admet-1474	39	15	a	a	DET
admet-1474	39	16	multifunctional	multifunctional	ADJ
admet-1474	39	17	pharmaceutical	pharmaceutical	ADJ
admet-1474	39	18	excipient	excipient	NOUN
admet-1474	39	19	[	[	X
admet-1474	39	20	13	13	NUM
admet-1474	39	21	]	]	PUNCT
admet-1474	39	22	.	.	PUNCT
admet-1474	40	1	cph	cph	PROPN
admet-1474	40	2	pectin	pectin	NOUN
admet-1474	40	3	is	be	AUX
admet-1474	40	4	known	know	VERB
admet-1474	40	5	to	to	PART
admet-1474	40	6	be	be	AUX
admet-1474	40	7	non	non	ADJ
admet-1474	40	8	-	-	ADJ
admet-1474	40	9	toxic	toxic	ADJ
admet-1474	40	10	and	and	CCONJ
admet-1474	40	11	swells	swell	VERB
admet-1474	40	12	at	at	ADP
admet-1474	40	13	varying	vary	VERB
admet-1474	40	14	extents	extent	NOUN
admet-1474	40	15	[	[	X
admet-1474	40	16	14,15	14,15	NUM
admet-1474	40	17	]	]	PUNCT
admet-1474	40	18	.	.	PUNCT
admet-1474	41	1	the	the	DET
admet-1474	41	2	swelling	swell	VERB
admet-1474	41	3	characteristics	characteristic	NOUN
admet-1474	41	4	of	of	ADP
admet-1474	41	5	cph	cph	PROPN
admet-1474	41	6	pectin	pectin	NOUN
admet-1474	41	7	make	make	VERB
admet-1474	41	8	it	it	PRON
admet-1474	41	9	a	a	DET
admet-1474	41	10	suitable	suitable	ADJ
admet-1474	41	11	binder	binder	NOUN
admet-1474	41	12	or	or	CCONJ
admet-1474	41	13	matrix	matrix	NOUN
admet-1474	41	14	in	in	ADP
admet-1474	41	15	controlled	control	VERB
admet-1474	41	16	-	-	PUNCT
admet-1474	41	17	release	release	NOUN
admet-1474	41	18	formulations	formulation	NOUN
admet-1474	41	19	[	[	X
admet-1474	41	20	15	15	NUM
admet-1474	41	21	]	]	PUNCT
admet-1474	41	22	.	.	PUNCT
admet-1474	42	1	indeed	indeed	ADV
admet-1474	42	2	there	there	PRON
admet-1474	42	3	have	have	AUX
admet-1474	42	4	been	be	AUX
admet-1474	42	5	previous	previous	ADJ
admet-1474	42	6	studies	study	NOUN
admet-1474	42	7	that	that	PRON
admet-1474	42	8	have	have	AUX
admet-1474	42	9	assessed	assess	VERB
admet-1474	42	10	chitosan	chitosan	NOUN
admet-1474	42	11	-	-	PUNCT
admet-1474	42	12	based	base	VERB
admet-1474	42	13	levodopa	levodopa	NOUN
admet-1474	42	14	carbidopa	carbidopa	NOUN
admet-1474	42	15	formulations	formulation	NOUN
admet-1474	42	16	using	use	VERB
admet-1474	42	17	different	different	ADJ
admet-1474	42	18	routes	route	NOUN
admet-1474	42	19	of	of	ADP
admet-1474	42	20	administration	administration	NOUN
admet-1474	42	21	;	;	PUNCT
admet-1474	42	22	intraduodenal	intraduodenal	ADJ
admet-1474	42	23	infusion	infusion	NOUN
admet-1474	42	24	,	,	PUNCT
admet-1474	42	25	nasal	nasal	NOUN
admet-1474	42	26	and	and	CCONJ
admet-1474	42	27	oral	oral	ADJ
admet-1474	42	28	[	[	X
admet-1474	42	29	16,17	16,17	NUM
admet-1474	42	30	]	]	PUNCT
admet-1474	42	31	.	.	PUNCT
admet-1474	43	1	however	however	ADV
admet-1474	43	2	,	,	PUNCT
admet-1474	43	3	there	there	PRON
admet-1474	43	4	is	be	VERB
admet-1474	43	5	a	a	DET
admet-1474	43	6	paucity	paucity	NOUN
admet-1474	43	7	of	of	ADP
admet-1474	43	8	data	datum	NOUN
admet-1474	43	9	on	on	ADP
admet-1474	43	10	the	the	DET
admet-1474	43	11	oral	oral	ADJ
admet-1474	43	12	chitosan	chitosan	NOUN
admet-1474	43	13	-	-	PUNCT
admet-1474	43	14	pectin	pectin	NOUN
admet-1474	43	15	-	-	PUNCT
admet-1474	43	16	based	base	VERB
admet-1474	43	17	multiparticulate	multiparticulate	ADJ
admet-1474	43	18	matrix	matrix	NOUN
admet-1474	43	19	of	of	ADP
admet-1474	43	20	levodopa	levodopa	NOUN
admet-1474	43	21	and	and	CCONJ
admet-1474	43	22	carbidopa	carbidopa	NOUN
admet-1474	43	23	.	.	PUNCT
admet-1474	44	1	for	for	ADP
admet-1474	44	2	an	an	DET
admet-1474	44	3	oral	oral	ADJ
admet-1474	44	4	formulation	formulation	NOUN
admet-1474	44	5	,	,	PUNCT
admet-1474	44	6	chitosan	chitosan	PROPN
admet-1474	44	7	has	have	VERB
admet-1474	44	8	several	several	ADJ
admet-1474	44	9	positively	positively	ADV
admet-1474	44	10	charged	charge	VERB
admet-1474	44	11	groups	group	NOUN
admet-1474	44	12	which	which	PRON
admet-1474	44	13	readily	readily	ADV
admet-1474	44	14	interact	interact	VERB
admet-1474	44	15	with	with	ADP
admet-1474	44	16	the	the	DET
admet-1474	44	17	negatively	negatively	ADV
admet-1474	44	18	charged	charge	VERB
admet-1474	44	19	mucous	mucous	ADJ
admet-1474	44	20	membranes	membrane	NOUN
admet-1474	44	21	of	of	ADP
admet-1474	44	22	the	the	DET
admet-1474	44	23	gastrointestinal	gastrointestinal	ADJ
admet-1474	44	24	tract	tract	NOUN
admet-1474	44	25	,	,	PUNCT
admet-1474	44	26	thereby	thereby	ADV
admet-1474	44	27	increasing	increase	VERB
admet-1474	44	28	adhesion	adhesion	NOUN
admet-1474	44	29	.	.	PUNCT
admet-1474	45	1	for	for	ADP
admet-1474	45	2	our	our	PRON
admet-1474	45	3	formulation	formulation	NOUN
admet-1474	45	4	,	,	PUNCT
admet-1474	45	5	the	the	DET
admet-1474	45	6	addition	addition	NOUN
admet-1474	45	7	of	of	ADP
admet-1474	45	8	pectin	pectin	NOUN
admet-1474	45	9	(	(	PUNCT
admet-1474	45	10	anionic	anionic	ADJ
admet-1474	45	11	polysaccharide	polysaccharide	NOUN
admet-1474	45	12	)	)	PUNCT
admet-1474	45	13	causes	cause	VERB
admet-1474	45	14	chitosan	chitosan	NOUN
admet-1474	45	15	and	and	CCONJ
admet-1474	45	16	pectin	pectin	NOUN
admet-1474	45	17	to	to	PART
admet-1474	45	18	interact	interact	VERB
admet-1474	45	19	and	and	CCONJ
admet-1474	45	20	form	form	VERB
admet-1474	45	21	a	a	DET
admet-1474	45	22	polyelectrolyte	polyelectrolyte	NOUN
admet-1474	45	23	complex	complex	NOUN
admet-1474	45	24	.	.	PUNCT
admet-1474	46	1	studies	study	NOUN
admet-1474	46	2	have	have	AUX
admet-1474	46	3	shown	show	VERB
admet-1474	46	4	that	that	SCONJ
admet-1474	46	5	polyelectrolyte	polyelectrolyte	NOUN
admet-1474	46	6	complexes	complex	NOUN
admet-1474	46	7	have	have	VERB
admet-1474	46	8	the	the	DET
admet-1474	46	9	ability	ability	NOUN
admet-1474	46	10	to	to	PART
admet-1474	46	11	encapsulate	encapsulate	VERB
admet-1474	46	12	drugs	drug	NOUN
admet-1474	46	13	in	in	ADP
admet-1474	46	14	a	a	DET
admet-1474	46	15	polymeric	polymeric	ADJ
admet-1474	46	16	matrix	matrix	NOUN
admet-1474	46	17	at	at	ADP
admet-1474	46	18	the	the	DET
admet-1474	46	19	molecular	molecular	ADJ
admet-1474	46	20	level	level	NOUN
admet-1474	46	21	,	,	PUNCT
admet-1474	46	22	thereby	thereby	ADV
admet-1474	46	23	enhancing	enhance	VERB
admet-1474	46	24	the	the	DET
admet-1474	46	25	physicochemical	physicochemical	ADJ
admet-1474	46	26	and	and	CCONJ
admet-1474	46	27	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	46	28	characteristics	characteristic	NOUN
admet-1474	46	29	of	of	ADP
admet-1474	46	30	drugs	drug	NOUN
admet-1474	46	31	.	.	PUNCT
admet-1474	47	1	the	the	DET
admet-1474	47	2	current	current	ADJ
admet-1474	47	3	study	study	NOUN
admet-1474	47	4	adopts	adopt	VERB
admet-1474	47	5	a	a	DET
admet-1474	47	6	simple	simple	ADJ
admet-1474	47	7	and	and	CCONJ
admet-1474	47	8	costeffective	costeffective	ADJ
admet-1474	47	9	formulation	formulation	NOUN
admet-1474	47	10	approach	approach	NOUN
admet-1474	47	11	,	,	PUNCT
admet-1474	47	12	using	use	VERB
admet-1474	47	13	optimized	optimize	VERB
admet-1474	47	14	chitosan	chitosan	NOUN
admet-1474	47	15	-	-	PUNCT
admet-1474	47	16	pectin	pectin	NOUN
admet-1474	47	17	-	-	PUNCT
admet-1474	47	18	based	base	VERB
admet-1474	47	19	formulations	formulation	NOUN
admet-1474	47	20	to	to	PART
admet-1474	47	21	be	be	AUX
admet-1474	47	22	administered	administer	VERB
admet-1474	47	23	via	via	ADP
admet-1474	47	24	the	the	DET
admet-1474	47	25	oral	oral	ADJ
admet-1474	47	26	route	route	NOUN
admet-1474	47	27	.	.	PUNCT
admet-1474	48	1	the	the	DET
admet-1474	48	2	formulation	formulation	NOUN
admet-1474	48	3	was	be	AUX
admet-1474	48	4	evaluated	evaluate	VERB
admet-1474	48	5	for	for	ADP
admet-1474	48	6	its	its	PRON
admet-1474	48	7	pharmaceutical	pharmaceutical	NOUN
admet-1474	48	8	and	and	CCONJ
admet-1474	48	9	in	in	ADP
admet-1474	48	10	vivo	vivo	ADJ
admet-1474	48	11	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	48	12	characteristics	characteristic	NOUN
admet-1474	48	13	.	.	PUNCT
admet-1474	49	1	experimental	experimental	ADJ
admet-1474	49	2	materials	material	NOUN
admet-1474	49	3	levodopa	levodopa	NOUN
admet-1474	49	4	and	and	CCONJ
admet-1474	49	5	carbidopa	carbidopa	NOUN
admet-1474	49	6	powders	powder	NOUN
admet-1474	49	7	,	,	PUNCT
admet-1474	49	8	low	low	ADJ
admet-1474	49	9	molecular	molecular	ADJ
admet-1474	49	10	weight	weight	NOUN
admet-1474	49	11	chitosan	chitosan	NOUN
admet-1474	49	12	and	and	CCONJ
admet-1474	49	13	microcrystalline	microcrystalline	NOUN
admet-1474	49	14	cellulose	cellulose	NOUN
admet-1474	49	15	,	,	PUNCT
admet-1474	49	16	were	be	AUX
admet-1474	49	17	purchased	purchase	VERB
admet-1474	49	18	from	from	ADP
admet-1474	49	19	sigma	sigma	PROPN
admet-1474	49	20	-	-	PUNCT
admet-1474	49	21	aldrich	aldrich	PROPN
admet-1474	49	22	(	(	PUNCT
admet-1474	49	23	st	st	PROPN
admet-1474	49	24	louis	louis	PROPN
admet-1474	49	25	,	,	PUNCT
admet-1474	49	26	missouri	missouri	PROPN
admet-1474	49	27	,	,	PUNCT
admet-1474	49	28	usa	usa	PROPN
admet-1474	49	29	)	)	PUNCT
admet-1474	49	30	.	.	PUNCT
admet-1474	50	1	sinemet	sinemet	PROPN
admet-1474	50	2	®	®	PROPN
admet-1474	50	3	cr	cr	PROPN
admet-1474	50	4	tablet	tablet	VERB
admet-1474	50	5	100/25	100/25	NUM
admet-1474	50	6	mg	mg	PROPN
admet-1474	50	7	(	(	PUNCT
admet-1474	50	8	merck	merck	PROPN
admet-1474	50	9	sharp	sharp	PROPN
admet-1474	50	10	&	&	CCONJ
admet-1474	50	11	dohme	dohme	PROPN
admet-1474	50	12	limited	limit	VERB
admet-1474	50	13	,	,	PUNCT
admet-1474	50	14	hertfordshire	hertfordshire	NOUN
admet-1474	50	15	,	,	PUNCT
admet-1474	50	16	uk	uk	PROPN
admet-1474	50	17	)	)	PUNCT
admet-1474	50	18	was	be	AUX
admet-1474	50	19	purchased	purchase	VERB
admet-1474	50	20	from	from	ADP
admet-1474	50	21	medimart	medimart	PROPN
admet-1474	50	22	pharmacy	pharmacy	NOUN
admet-1474	50	23	,	,	PUNCT
admet-1474	50	24	accra	accra	PROPN
admet-1474	50	25	,	,	PUNCT
admet-1474	50	26	ghana	ghana	PROPN
admet-1474	50	27	.	.	PUNCT
admet-1474	51	1	all	all	DET
admet-1474	51	2	solvents	solvent	NOUN
admet-1474	51	3	admet	admet	PROPN
admet-1474	51	4	&	&	CCONJ
admet-1474	51	5	dmpk	dmpk	PROPN
admet-1474	51	6	11(1	11(1	NUM
admet-1474	51	7	)	)	PUNCT
admet-1474	51	8	(	(	PUNCT
admet-1474	51	9	2023	2023	NUM
admet-1474	51	10	)	)	PUNCT
admet-1474	51	11	97	97	NUM
admet-1474	51	12	-	-	SYM
admet-1474	51	13	115	115	NUM
admet-1474	51	14	evaluation	evaluation	NOUN
admet-1474	51	15	of	of	ADP
admet-1474	51	16	re	re	ADJ
admet-1474	51	17	-	-	ADJ
admet-1474	51	18	formulated	formulate	VERB
admet-1474	51	19	levodopa	levodopa	NOUN
admet-1474	51	20	and	and	CCONJ
admet-1474	51	21	carbidopa	carbidopa	NOUN
admet-1474	51	22	doi	doi	NOUN
admet-1474	51	23	:	:	PUNCT
admet-1474	51	24	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	51	25	99	99	NUM
admet-1474	51	26	used	use	VERB
admet-1474	51	27	for	for	ADP
admet-1474	51	28	chromatography	chromatography	NOUN
admet-1474	51	29	were	be	AUX
admet-1474	51	30	of	of	ADP
admet-1474	51	31	high	high	ADJ
admet-1474	51	32	-	-	PUNCT
admet-1474	51	33	performance	performance	NOUN
admet-1474	51	34	liquid	liquid	ADJ
admet-1474	51	35	chromatography	chromatography	NOUN
admet-1474	51	36	(	(	PUNCT
admet-1474	51	37	hplc	hplc	NOUN
admet-1474	51	38	)	)	PUNCT
admet-1474	51	39	purity	purity	NOUN
admet-1474	51	40	.	.	PUNCT
admet-1474	52	1	all	all	DET
admet-1474	52	2	other	other	ADJ
admet-1474	52	3	reagents	reagent	NOUN
admet-1474	52	4	used	use	VERB
admet-1474	52	5	were	be	AUX
admet-1474	52	6	purchased	purchase	VERB
admet-1474	52	7	from	from	ADP
admet-1474	52	8	approved	approve	VERB
admet-1474	52	9	suppliers	supplier	NOUN
admet-1474	52	10	and	and	CCONJ
admet-1474	52	11	were	be	AUX
admet-1474	52	12	of	of	ADP
admet-1474	52	13	analytical	analytical	ADJ
admet-1474	52	14	grade	grade	NOUN
admet-1474	52	15	.	.	PUNCT
admet-1474	53	1	extraction	extraction	NOUN
admet-1474	53	2	of	of	ADP
admet-1474	53	3	pectin	pectin	NOUN
admet-1474	53	4	cocoa	cocoa	NOUN
admet-1474	53	5	pods	pod	NOUN
admet-1474	53	6	were	be	AUX
admet-1474	53	7	harvested	harvest	VERB
admet-1474	53	8	from	from	ADP
admet-1474	53	9	theobroma	theobroma	PROPN
admet-1474	53	10	cacao	cacao	PROPN
admet-1474	53	11	l.	l.	PROPN
admet-1474	53	12	trees	trees	PROPN
admet-1474	53	13	.	.	PUNCT
admet-1474	54	1	to	to	PART
admet-1474	54	2	avoid	avoid	VERB
admet-1474	54	3	pigmentation	pigmentation	NOUN
admet-1474	54	4	,	,	PUNCT
admet-1474	54	5	the	the	DET
admet-1474	54	6	pulp	pulp	NOUN
admet-1474	54	7	and	and	CCONJ
admet-1474	54	8	seeds	seed	NOUN
admet-1474	54	9	were	be	AUX
admet-1474	54	10	removed	remove	VERB
admet-1474	54	11	.	.	PUNCT
admet-1474	55	1	afterwards	afterwards	ADV
admet-1474	55	2	,	,	PUNCT
admet-1474	55	3	the	the	DET
admet-1474	55	4	pod	pod	NOUN
admet-1474	55	5	husks	husk	NOUN
admet-1474	55	6	were	be	AUX
admet-1474	55	7	peeled	peel	VERB
admet-1474	55	8	and	and	CCONJ
admet-1474	55	9	blended	blend	VERB
admet-1474	55	10	.	.	PUNCT
admet-1474	56	1	extraction	extraction	NOUN
admet-1474	56	2	of	of	ADP
admet-1474	56	3	pectin	pectin	NOUN
admet-1474	56	4	from	from	ADP
admet-1474	56	5	fresh	fresh	ADJ
admet-1474	56	6	cph	cph	PROPN
admet-1474	56	7	was	be	AUX
admet-1474	56	8	done	do	VERB
admet-1474	56	9	in	in	ADP
admet-1474	56	10	a	a	DET
admet-1474	56	11	water	water	NOUN
admet-1474	56	12	bath	bath	NOUN
admet-1474	56	13	(	(	PUNCT
admet-1474	56	14	50	50	NUM
admet-1474	56	15	°	°	NOUN
admet-1474	56	16	c	c	NOUN
admet-1474	56	17	)	)	PUNCT
admet-1474	56	18	and	and	CCONJ
admet-1474	56	19	precipitated	precipitate	VERB
admet-1474	56	20	with	with	ADP
admet-1474	56	21	ethanol	ethanol	NOUN
admet-1474	56	22	,	,	PUNCT
admet-1474	56	23	according	accord	VERB
admet-1474	56	24	to	to	ADP
admet-1474	56	25	a	a	DET
admet-1474	56	26	procedure	procedure	NOUN
admet-1474	56	27	previously	previously	ADV
admet-1474	56	28	described	describe	VERB
admet-1474	56	29	by	by	ADP
admet-1474	56	30	adi	adi	PROPN
admet-1474	56	31	-	-	PUNCT
admet-1474	56	32	dako	dako	PROPN
admet-1474	56	33	et	et	PROPN
admet-1474	56	34	al	al	PROPN
admet-1474	56	35	.	.	PUNCT
admet-1474	57	1	[	[	X
admet-1474	57	2	15	15	NUM
admet-1474	57	3	]	]	PUNCT
admet-1474	57	4	,	,	PUNCT
admet-1474	57	5	with	with	ADP
admet-1474	57	6	minor	minor	ADJ
admet-1474	57	7	modifications	modification	NOUN
admet-1474	57	8	.	.	PUNCT
admet-1474	58	1	pectin	pectin	NOUN
admet-1474	58	2	yield	yield	NOUN
admet-1474	58	3	was	be	AUX
admet-1474	58	4	then	then	ADV
admet-1474	58	5	determined	determine	VERB
admet-1474	58	6	,	,	PUNCT
admet-1474	58	7	and	and	CCONJ
admet-1474	58	8	samples	sample	NOUN
admet-1474	58	9	were	be	AUX
admet-1474	58	10	covered	cover	VERB
admet-1474	58	11	with	with	ADP
admet-1474	58	12	aluminium	aluminium	NOUN
admet-1474	58	13	foil	foil	NOUN
admet-1474	58	14	and	and	CCONJ
admet-1474	58	15	kept	keep	VERB
admet-1474	58	16	in	in	ADP
admet-1474	58	17	a	a	DET
admet-1474	58	18	desiccant	desiccant	NOUN
admet-1474	58	19	.	.	PUNCT
admet-1474	59	1	characterization	characterization	NOUN
admet-1474	59	2	of	of	ADP
admet-1474	59	3	extracted	extract	VERB
admet-1474	59	4	hot	hot	ADJ
admet-1474	59	5	water	water	NOUN
admet-1474	59	6	soluble	soluble	ADJ
admet-1474	59	7	cph	cph	NOUN
admet-1474	59	8	pectin	pectin	NOUN
admet-1474	59	9	by	by	ADP
admet-1474	59	10	fourier	fourier	ADJ
admet-1474	59	11	transform	transform	NOUN
admet-1474	59	12	infrared	infrared	ADJ
admet-1474	59	13	spectroscopy	spectroscopy	NOUN
admet-1474	59	14	(	(	PUNCT
admet-1474	59	15	ftir	ftir	PROPN
admet-1474	59	16	)	)	PUNCT
admet-1474	59	17	ftir	ftir	PROPN
admet-1474	59	18	spectrum	spectrum	NOUN
admet-1474	59	19	of	of	ADP
admet-1474	59	20	the	the	DET
admet-1474	59	21	cph	cph	PROPN
admet-1474	59	22	pectin	pectin	NOUN
admet-1474	59	23	was	be	AUX
admet-1474	59	24	done	do	VERB
admet-1474	59	25	using	use	VERB
admet-1474	59	26	a	a	DET
admet-1474	59	27	perkin	perkin	PROPN
admet-1474	59	28	elmer	elmer	PROPN
admet-1474	59	29	uatr	uatr	PROPN
admet-1474	59	30	-	-	PUNCT
admet-1474	59	31	ii	ii	PROPN
admet-1474	59	32	ftir	ftir	PROPN
admet-1474	59	33	spectrometer	spectrometer	NOUN
admet-1474	59	34	(	(	PUNCT
admet-1474	59	35	perkin	perkin	PROPN
admet-1474	59	36	elmer	elmer	PROPN
admet-1474	59	37	ltd	ltd	PROPN
admet-1474	59	38	,	,	PUNCT
admet-1474	59	39	beaconsfield	beaconsfield	PROPN
admet-1474	59	40	,	,	PUNCT
admet-1474	59	41	uk	uk	PROPN
admet-1474	59	42	)	)	PUNCT
admet-1474	59	43	.	.	PUNCT
admet-1474	60	1	the	the	DET
admet-1474	60	2	pectin	pectin	NOUN
admet-1474	60	3	was	be	AUX
admet-1474	60	4	placed	place	VERB
admet-1474	60	5	onto	onto	ADP
admet-1474	60	6	the	the	DET
admet-1474	60	7	attenuated	attenuate	VERB
admet-1474	60	8	total	total	ADJ
admet-1474	60	9	reflectance	reflectance	NOUN
admet-1474	60	10	(	(	PUNCT
admet-1474	60	11	atr	atr	PROPN
admet-1474	60	12	)	)	PUNCT
admet-1474	60	13	crystal	crystal	NOUN
admet-1474	60	14	surface	surface	NOUN
admet-1474	60	15	and	and	CCONJ
admet-1474	60	16	the	the	DET
admet-1474	60	17	spectrum	spectrum	NOUN
admet-1474	60	18	was	be	AUX
admet-1474	60	19	determined	determine	VERB
admet-1474	60	20	over	over	ADP
admet-1474	60	21	a	a	DET
admet-1474	60	22	wavelength	wavelength	NOUN
admet-1474	60	23	range	range	NOUN
admet-1474	60	24	of	of	ADP
admet-1474	60	25	4000	4000	NUM
admet-1474	60	26	-	-	SYM
admet-1474	60	27	500	500	NUM
admet-1474	60	28	cm−1	cm−1	NOUN
admet-1474	60	29	and	and	CCONJ
admet-1474	60	30	a	a	DET
admet-1474	60	31	resolution	resolution	NOUN
admet-1474	60	32	of	of	ADP
admet-1474	60	33	1.0	1.0	NUM
admet-1474	60	34	cm1	cm1	NOUN
admet-1474	60	35	.	.	PUNCT
admet-1474	61	1	formulation	formulation	NOUN
admet-1474	61	2	of	of	ADP
admet-1474	61	3	multiparticulate	multiparticulate	ADJ
admet-1474	61	4	matrix	matrix	NOUN
admet-1474	61	5	of	of	ADP
admet-1474	61	6	levodopa	levodopa	NOUN
admet-1474	61	7	and	and	CCONJ
admet-1474	61	8	carbidopa	carbidopa	ADV
admet-1474	61	9	briefly	briefly	ADV
admet-1474	61	10	,	,	PUNCT
admet-1474	61	11	chitosan	chitosan	PROPN
admet-1474	61	12	was	be	AUX
admet-1474	61	13	weighed	weigh	VERB
admet-1474	61	14	and	and	CCONJ
admet-1474	61	15	dissolved	dissolve	VERB
admet-1474	61	16	in	in	ADP
admet-1474	61	17	1	1	NUM
admet-1474	61	18	%	%	NOUN
admet-1474	61	19	glacial	glacial	ADJ
admet-1474	61	20	acetic	acetic	ADJ
admet-1474	61	21	acid	acid	NOUN
admet-1474	61	22	.	.	PUNCT
admet-1474	62	1	the	the	DET
admet-1474	62	2	mixed	mixed	ADJ
admet-1474	62	3	powder	powder	NOUN
admet-1474	62	4	of	of	ADP
admet-1474	62	5	levodopa	levodopa	NOUN
admet-1474	62	6	and	and	CCONJ
admet-1474	62	7	carbidopa	carbidopa	NOUN
admet-1474	62	8	was	be	AUX
admet-1474	62	9	triturated	triturate	VERB
admet-1474	62	10	with	with	ADP
admet-1474	62	11	the	the	DET
admet-1474	62	12	chitosan	chitosan	NOUN
admet-1474	62	13	solution	solution	NOUN
admet-1474	62	14	until	until	SCONJ
admet-1474	62	15	a	a	DET
admet-1474	62	16	uniform	uniform	ADJ
admet-1474	62	17	mixture	mixture	NOUN
admet-1474	62	18	was	be	AUX
admet-1474	62	19	obtained	obtain	VERB
admet-1474	62	20	.	.	PUNCT
admet-1474	63	1	an	an	DET
admet-1474	63	2	adequate	adequate	ADJ
admet-1474	63	3	volume	volume	NOUN
admet-1474	63	4	of	of	ADP
admet-1474	63	5	hot	hot	ADJ
admet-1474	63	6	water	water	NOUN
admet-1474	63	7	was	be	AUX
admet-1474	63	8	added	add	VERB
admet-1474	63	9	to	to	ADP
admet-1474	63	10	the	the	DET
admet-1474	63	11	cph	cph	PROPN
admet-1474	63	12	pectin	pectin	NOUN
admet-1474	63	13	with	with	ADP
admet-1474	63	14	stirring	stirring	NOUN
admet-1474	63	15	.	.	PUNCT
admet-1474	64	1	the	the	DET
admet-1474	64	2	mixture	mixture	NOUN
admet-1474	64	3	was	be	AUX
admet-1474	64	4	dried	dry	VERB
admet-1474	64	5	at	at	ADP
admet-1474	64	6	30	30	NUM
admet-1474	64	7	°	°	ADP
admet-1474	64	8	c	c	NOUN
admet-1474	64	9	for	for	ADP
admet-1474	64	10	8	8	NUM
admet-1474	64	11	hr	hr	NOUN
admet-1474	64	12	.	.	PUNCT
admet-1474	65	1	afterwards	afterwards	ADV
admet-1474	65	2	,	,	PUNCT
admet-1474	65	3	the	the	DET
admet-1474	65	4	dried	dry	VERB
admet-1474	65	5	mass	mass	NOUN
admet-1474	65	6	was	be	AUX
admet-1474	65	7	milled	mill	VERB
admet-1474	65	8	,	,	PUNCT
admet-1474	65	9	passed	pass	VERB
admet-1474	65	10	through	through	ADP
admet-1474	65	11	a	a	DET
admet-1474	65	12	sieve	sieve	NOUN
admet-1474	65	13	(	(	PUNCT
admet-1474	65	14	no	no	INTJ
admet-1474	65	15	.	.	NOUN
admet-1474	65	16	40	40	NUM
admet-1474	65	17	)	)	PUNCT
admet-1474	65	18	,	,	PUNCT
admet-1474	65	19	weighed	weigh	VERB
admet-1474	65	20	and	and	CCONJ
admet-1474	65	21	stored	store	VERB
admet-1474	65	22	in	in	ADP
admet-1474	65	23	glass	glass	NOUN
admet-1474	65	24	containers	container	NOUN
admet-1474	65	25	at	at	ADP
admet-1474	65	26	room	room	NOUN
admet-1474	65	27	temperature	temperature	NOUN
admet-1474	65	28	.	.	PUNCT
admet-1474	66	1	the	the	DET
admet-1474	66	2	formulation	formulation	NOUN
admet-1474	66	3	details	detail	NOUN
admet-1474	66	4	of	of	ADP
admet-1474	66	5	the	the	DET
admet-1474	66	6	various	various	ADJ
admet-1474	66	7	multiparticulate	multiparticulate	ADJ
admet-1474	66	8	matrices	matrix	NOUN
admet-1474	66	9	of	of	ADP
admet-1474	66	10	levodopa	levodopa	NOUN
admet-1474	66	11	/	/	SYM
admet-1474	66	12	carbidopa	carbidopa	NOUN
admet-1474	66	13	(	(	PUNCT
admet-1474	66	14	f1	f1	NOUN
admet-1474	66	15	,	,	PUNCT
admet-1474	66	16	f2	f2	PROPN
admet-1474	66	17	,	,	PUNCT
admet-1474	66	18	f3	f3	ADJ
admet-1474	66	19	,	,	PUNCT
admet-1474	66	20	f4	f4	ADJ
admet-1474	66	21	and	and	CCONJ
admet-1474	66	22	f5	f5	PROPN
admet-1474	66	23	)	)	PUNCT
admet-1474	66	24	are	be	AUX
admet-1474	66	25	summarized	summarize	VERB
admet-1474	66	26	in	in	ADP
admet-1474	66	27	table	table	NOUN
admet-1474	66	28	1	1	NUM
admet-1474	66	29	.	.	PUNCT
admet-1474	66	30	table	table	NOUN
admet-1474	66	31	1	1	NUM
admet-1474	66	32	.	.	PUNCT
admet-1474	67	1	composition	composition	NOUN
admet-1474	67	2	of	of	ADP
admet-1474	67	3	chitosan	chitosan	NOUN
admet-1474	67	4	-	-	PUNCT
admet-1474	67	5	pectin	pectin	NOUN
admet-1474	67	6	-	-	PUNCT
admet-1474	67	7	based	base	VERB
admet-1474	67	8	multiparticulate	multiparticulate	ADJ
admet-1474	67	9	matrix	matrix	NOUN
admet-1474	67	10	of	of	ADP
admet-1474	67	11	levodopa	levodopa	NOUN
admet-1474	67	12	/	/	SYM
admet-1474	67	13	carbidopa	carbidopa	NOUN
admet-1474	67	14	ingredient	ingredient	NOUN
admet-1474	67	15	f1	f1	NOUN
admet-1474	67	16	(	(	PUNCT
admet-1474	67	17	mg	mg	PROPN
admet-1474	67	18	)	)	PUNCT
admet-1474	67	19	f2	f2	PROPN
admet-1474	67	20	(	(	PUNCT
admet-1474	67	21	mg	mg	NOUN
admet-1474	67	22	)	)	PUNCT
admet-1474	67	23	f3	f3	NOUN
admet-1474	67	24	(	(	PUNCT
admet-1474	67	25	mg	mg	PROPN
admet-1474	67	26	)	)	PUNCT
admet-1474	67	27	f4	f4	PROPN
admet-1474	67	28	(	(	PUNCT
admet-1474	67	29	mg	mg	NOUN
admet-1474	67	30	)	)	PUNCT
admet-1474	67	31	f5	f5	PROPN
admet-1474	67	32	(	(	PUNCT
admet-1474	67	33	mg	mg	NOUN
admet-1474	67	34	)	)	PUNCT
admet-1474	67	35	levodopa	levodopa	NOUN
admet-1474	67	36	100	100	NUM
admet-1474	67	37	100	100	NUM
admet-1474	67	38	100	100	NUM
admet-1474	67	39	100	100	NUM
admet-1474	67	40	100	100	NUM
admet-1474	67	41	carbidopa	carbidopa	NOUN
admet-1474	67	42	25	25	NUM
admet-1474	67	43	25	25	NUM
admet-1474	67	44	25	25	NUM
admet-1474	67	45	25	25	NUM
admet-1474	67	46	25	25	NUM
admet-1474	67	47	cs	cs	PROPN
admet-1474	67	48	100	100	NUM
admet-1474	67	49	100	100	NUM
admet-1474	67	50	100	100	NUM
admet-1474	67	51	100	100	NUM
admet-1474	67	52	100	100	NUM
admet-1474	67	53	cph	cph	NOUN
admet-1474	67	54	-	-	PUNCT
admet-1474	67	55	pectin	pectin	NOUN
admet-1474	67	56	50	50	NUM
admet-1474	67	57	100	100	NUM
admet-1474	67	58	100	100	NUM
admet-1474	67	59	100	100	NUM
admet-1474	67	60	ha	ha	INTJ
admet-1474	67	61	10	10	NUM
admet-1474	67	62	cacl2	cacl2	NOUN
admet-1474	67	63	50	50	NUM
admet-1474	67	64	mcc	mcc	NOUN
admet-1474	67	65	200	200	NUM
admet-1474	67	66	150	150	NUM
admet-1474	67	67	100	100	NUM
admet-1474	67	68	90	90	NUM
admet-1474	67	69	50	50	NUM
admet-1474	67	70	total	total	NOUN
admet-1474	67	71	425.0	425.0	NUM
admet-1474	67	72	425.0	425.0	NUM
admet-1474	67	73	425.0	425.0	NUM
admet-1474	67	74	425.0	425.0	NUM
admet-1474	67	75	425.0	425.0	NUM
admet-1474	67	76	cs	cs	NOUN
admet-1474	67	77	=	=	SYM
admet-1474	67	78	chitosan	chitosan	PROPN
admet-1474	67	79	,	,	PUNCT
admet-1474	67	80	mcc	mcc	NOUN
admet-1474	67	81	=	=	NOUN
admet-1474	67	82	microcrystalline	microcrystalline	NOUN
admet-1474	67	83	cellulose	cellulose	NOUN
admet-1474	67	84	,	,	PUNCT
admet-1474	67	85	ha	ha	INTJ
admet-1474	67	86	=	=	ADJ
admet-1474	67	87	hydroxyapatite	hydroxyapatite	NOUN
admet-1474	67	88	,	,	PUNCT
admet-1474	67	89	cacl2	cacl2	NOUN
admet-1474	67	90	=	=	SYM
admet-1474	67	91	calcium	calcium	NOUN
admet-1474	67	92	chloride	chloride	NOUN
admet-1474	67	93	,	,	PUNCT
admet-1474	67	94	f1	f1	NOUN
admet-1474	67	95	=	=	SYM
admet-1474	67	96	formulation	formulation	NOUN
admet-1474	67	97	1	1	NUM
admet-1474	67	98	,	,	PUNCT
admet-1474	67	99	f2	f2	ADJ
admet-1474	67	100	=	=	NOUN
admet-1474	67	101	formulation	formulation	NOUN
admet-1474	67	102	2	2	NUM
admet-1474	67	103	,	,	PUNCT
admet-1474	67	104	f3	f3	ADJ
admet-1474	67	105	=	=	SYM
admet-1474	67	106	formulation	formulation	NOUN
admet-1474	67	107	3	3	NUM
admet-1474	67	108	,	,	PUNCT
admet-1474	67	109	f4	f4	NOUN
admet-1474	67	110	=	=	SYM
admet-1474	67	111	formulation	formulation	NOUN
admet-1474	67	112	4	4	NUM
admet-1474	67	113	and	and	CCONJ
admet-1474	67	114	f5	f5	ADJ
admet-1474	67	115	=	=	SYM
admet-1474	67	116	formulation	formulation	NOUN
admet-1474	67	117	5	5	NUM
admet-1474	67	118	drug	drug	NOUN
admet-1474	67	119	-	-	PUNCT
admet-1474	67	120	excipient	excipient	NOUN
admet-1474	67	121	compatibility	compatibility	NOUN
admet-1474	67	122	a	a	DET
admet-1474	67	123	perkin	perkin	PROPN
admet-1474	67	124	elmer	elmer	PROPN
admet-1474	67	125	uatr	uatr	PROPN
admet-1474	67	126	-	-	PUNCT
admet-1474	67	127	ii	ii	PROPN
admet-1474	67	128	ftir	ftir	PROPN
admet-1474	67	129	spectrophotometer	spectrophotometer	PROPN
admet-1474	67	130	(	(	PUNCT
admet-1474	67	131	perkin	perkin	PROPN
admet-1474	67	132	elmer	elmer	PROPN
admet-1474	67	133	ltd	ltd	PROPN
admet-1474	67	134	,	,	PUNCT
admet-1474	67	135	beaconsfield	beaconsfield	PROPN
admet-1474	67	136	,	,	PUNCT
admet-1474	67	137	uk	uk	PROPN
admet-1474	67	138	)	)	PUNCT
admet-1474	67	139	operating	operate	VERB
admet-1474	67	140	on	on	ADP
admet-1474	67	141	diamond	diamond	NOUN
admet-1474	67	142	atr	atr	NOUN
admet-1474	67	143	was	be	AUX
admet-1474	67	144	used	use	VERB
admet-1474	67	145	to	to	PART
admet-1474	67	146	evaluate	evaluate	VERB
admet-1474	67	147	drug	drug	NOUN
admet-1474	67	148	-	-	PUNCT
admet-1474	67	149	excipient	excipient	NOUN
admet-1474	67	150	compatibility	compatibility	NOUN
admet-1474	67	151	.	.	PUNCT
admet-1474	68	1	the	the	DET
admet-1474	68	2	spectra	spectra	NOUN
admet-1474	68	3	of	of	ADP
admet-1474	68	4	levodopa	levodopa	NOUN
admet-1474	68	5	,	,	PUNCT
admet-1474	68	6	carbidopa	carbidopa	ADV
admet-1474	68	7	,	,	PUNCT
admet-1474	68	8	chitosan	chitosan	NOUN
admet-1474	68	9	,	,	PUNCT
admet-1474	68	10	pectin	pectin	NOUN
admet-1474	68	11	and	and	CCONJ
admet-1474	68	12	the	the	DET
admet-1474	68	13	chitosan	chitosan	NOUN
admet-1474	68	14	-	-	PUNCT
admet-1474	68	15	pectin	pectin	NOUN
admet-1474	68	16	-	-	PUNCT
admet-1474	68	17	based	base	VERB
admet-1474	68	18	matrix	matrix	NOUN
admet-1474	68	19	were	be	AUX
admet-1474	68	20	measured	measure	VERB
admet-1474	68	21	over	over	ADP
admet-1474	68	22	a	a	DET
admet-1474	68	23	wavelength	wavelength	NOUN
admet-1474	68	24	range	range	NOUN
admet-1474	68	25	of	of	ADP
admet-1474	68	26	4000500	4000500	NUM
admet-1474	68	27	cm−1	cm−1	NOUN
admet-1474	68	28	and	and	CCONJ
admet-1474	68	29	at	at	ADP
admet-1474	68	30	a	a	DET
admet-1474	68	31	resolution	resolution	NOUN
admet-1474	68	32	of	of	ADP
admet-1474	68	33	1.0	1.0	NUM
admet-1474	68	34	cm1	cm1	NOUN
admet-1474	68	35	.	.	PUNCT
admet-1474	69	1	spectra	spectra	PROPN
admet-1474	69	2	for	for	ADP
admet-1474	69	3	levodopa	levodopa	NOUN
admet-1474	69	4	,	,	PUNCT
admet-1474	69	5	carbidopa	carbidopa	ADV
admet-1474	69	6	,	,	PUNCT
admet-1474	69	7	chitosan	chitosan	NOUN
admet-1474	69	8	,	,	PUNCT
admet-1474	69	9	pectin	pectin	NOUN
admet-1474	69	10	and	and	CCONJ
admet-1474	69	11	the	the	DET
admet-1474	69	12	chitosanpectin	chitosanpectin	NOUN
admet-1474	69	13	-	-	PUNCT
admet-1474	69	14	based	base	VERB
admet-1474	69	15	matrix	matrix	NOUN
admet-1474	69	16	of	of	ADP
admet-1474	69	17	levodopa	levodopa	NOUN
admet-1474	69	18	/	/	SYM
admet-1474	69	19	carbidopa	carbidopa	NOUN
admet-1474	69	20	were	be	AUX
admet-1474	69	21	superimposed	superimpose	VERB
admet-1474	69	22	.	.	PUNCT
admet-1474	70	1	flow	flow	NOUN
admet-1474	70	2	properties	property	NOUN
admet-1474	70	3	of	of	ADP
admet-1474	70	4	chitosan	chitosan	NOUN
admet-1474	70	5	-	-	PUNCT
admet-1474	70	6	pectin	pectin	NOUN
admet-1474	70	7	-	-	PUNCT
admet-1474	70	8	based	base	VERB
admet-1474	70	9	multiparticulate	multiparticulate	ADJ
admet-1474	70	10	matrix	matrix	NOUN
admet-1474	70	11	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	70	12	emelia	emelia	PROPN
admet-1474	70	13	priscilla	priscilla	PROPN
admet-1474	70	14	imbeah	imbeah	PROPN
admet-1474	70	15	et	et	PROPN
admet-1474	70	16	al	al	PROPN
admet-1474	70	17	.	.	PROPN
admet-1474	70	18	admet	admet	PROPN
admet-1474	70	19	&	&	CCONJ
admet-1474	70	20	dmpk	dmpk	PROPN
admet-1474	70	21	11(1	11(1	NUM
admet-1474	70	22	)	)	PUNCT
admet-1474	70	23	(	(	PUNCT
admet-1474	70	24	2023	2023	NUM
admet-1474	70	25	)	)	PUNCT
admet-1474	70	26	97	97	NUM
admet-1474	70	27	-	-	SYM
admet-1474	70	28	115	115	NUM
admet-1474	70	29	100	100	NUM
admet-1474	70	30	briefly	briefly	ADV
admet-1474	70	31	,	,	PUNCT
admet-1474	70	32	3	3	NUM
admet-1474	70	33	g	g	NOUN
admet-1474	70	34	of	of	ADP
admet-1474	70	35	the	the	DET
admet-1474	70	36	various	various	ADJ
admet-1474	70	37	formulations	formulation	NOUN
admet-1474	70	38	were	be	AUX
admet-1474	70	39	weighed	weigh	VERB
admet-1474	70	40	into	into	ADP
admet-1474	70	41	a	a	DET
admet-1474	70	42	100	100	NUM
admet-1474	70	43	ml	ml	NOUN
admet-1474	70	44	graduated	graduate	VERB
admet-1474	70	45	measuring	measure	VERB
admet-1474	70	46	cylinder	cylinder	NOUN
admet-1474	70	47	and	and	CCONJ
admet-1474	70	48	the	the	DET
admet-1474	70	49	volume	volume	NOUN
admet-1474	70	50	occupied	occupy	VERB
admet-1474	70	51	was	be	AUX
admet-1474	70	52	noted	note	VERB
admet-1474	70	53	as	as	ADP
admet-1474	70	54	v1	v1	NOUN
admet-1474	70	55	.	.	PUNCT
admet-1474	71	1	the	the	DET
admet-1474	71	2	cylinder	cylinder	NOUN
admet-1474	71	3	was	be	AUX
admet-1474	71	4	then	then	ADV
admet-1474	71	5	tapped	tap	VERB
admet-1474	71	6	until	until	SCONJ
admet-1474	71	7	the	the	DET
admet-1474	71	8	powders	powder	NOUN
admet-1474	71	9	were	be	AUX
admet-1474	71	10	consolidated	consolidate	VERB
admet-1474	71	11	.	.	PUNCT
admet-1474	72	1	the	the	DET
admet-1474	72	2	volume	volume	NOUN
admet-1474	72	3	obtained	obtain	VERB
admet-1474	72	4	after	after	ADP
admet-1474	72	5	tapping	tapping	NOUN
admet-1474	72	6	was	be	AUX
admet-1474	72	7	designated	designate	VERB
admet-1474	72	8	v2	v2	NOUN
admet-1474	72	9	.	.	PUNCT
admet-1474	73	1	the	the	DET
admet-1474	73	2	tapped	tap	VERB
admet-1474	73	3	and	and	CCONJ
admet-1474	73	4	bulk	bulk	ADJ
admet-1474	73	5	densities	density	NOUN
admet-1474	73	6	,	,	PUNCT
admet-1474	73	7	carr	carr	PROPN
admet-1474	73	8	’s	’s	PART
admet-1474	73	9	index	index	NOUN
admet-1474	73	10	and	and	CCONJ
admet-1474	73	11	hausner	hausner	NOUN
admet-1474	73	12	ratio	ratio	NOUN
admet-1474	73	13	,	,	PUNCT
admet-1474	73	14	were	be	AUX
admet-1474	73	15	estimated	estimate	VERB
admet-1474	73	16	based	base	VERB
admet-1474	73	17	on	on	ADP
admet-1474	73	18	the	the	DET
admet-1474	73	19	formulae	formulae	NOUN
admet-1474	73	20	:	:	PUNCT
admet-1474	73	21	weight	weight	NOUN
admet-1474	73	22	of	of	ADP
admet-1474	73	23	formulation	formulation	NOUN
admet-1474	73	24	tapped	tap	VERB
admet-1474	73	25	density	density	NOUN
admet-1474	73	26	=	=	PUNCT
admet-1474	73	27	tapped	tap	VERB
admet-1474	73	28	volume	volume	NOUN
admet-1474	73	29	formulation	formulation	NOUN
admet-1474	73	30	weight	weight	NOUN
admet-1474	73	31	bulk	bulk	NOUN
admet-1474	73	32	density	density	NOUN
admet-1474	73	33	=	=	SYM
admet-1474	73	34	bulk	bulk	ADJ
admet-1474	73	35	volume	volume	NOUN
admet-1474	73	36	(	(	PUNCT
admet-1474	73	37	tapped	tap	VERB
admet-1474	73	38	density	density	NOUN
admet-1474	73	39	bulk	bulk	ADJ
admet-1474	73	40	density	density	NOUN
admet-1474	73	41	)	)	PUNCT
admet-1474	73	42	carr	carr	PROPN
admet-1474	73	43	's	's	PART
admet-1474	73	44	compressability	compressability	NOUN
admet-1474	73	45	index	index	NOUN
admet-1474	73	46	=	=	PUNCT
admet-1474	73	47	tapped	tap	VERB
admet-1474	73	48	density	density	NOUN
admet-1474	73	49	tapped	tap	VERB
admet-1474	73	50	density	density	NOUN
admet-1474	73	51	hausner	hausner	NOUN
admet-1474	73	52	ration	ration	NOUN
admet-1474	73	53	=	=	SYM
admet-1474	73	54	bulk	bulk	ADJ
admet-1474	73	55	density	density	NOUN
admet-1474	73	56	in	in	ADP
admet-1474	73	57	order	order	NOUN
admet-1474	73	58	to	to	PART
admet-1474	73	59	determine	determine	VERB
admet-1474	73	60	the	the	DET
admet-1474	73	61	angle	angle	NOUN
admet-1474	73	62	of	of	ADP
admet-1474	73	63	repose	repose	NOUN
admet-1474	73	64	,	,	PUNCT
admet-1474	73	65	5	5	NUM
admet-1474	73	66	g	g	NOUN
admet-1474	73	67	of	of	ADP
admet-1474	73	68	the	the	DET
admet-1474	73	69	formulations	formulation	NOUN
admet-1474	73	70	were	be	AUX
admet-1474	73	71	weighed	weigh	VERB
admet-1474	73	72	,	,	PUNCT
admet-1474	73	73	transferred	transfer	VERB
admet-1474	73	74	into	into	ADP
admet-1474	73	75	a	a	DET
admet-1474	73	76	clamped	clamp	VERB
admet-1474	73	77	funnel	funnel	NOUN
admet-1474	73	78	(	(	PUNCT
admet-1474	73	79	with	with	ADP
admet-1474	73	80	the	the	DET
admet-1474	73	81	tip	tip	NOUN
admet-1474	73	82	about	about	ADV
admet-1474	73	83	10	10	NUM
admet-1474	73	84	cm	cm	NOUN
admet-1474	73	85	from	from	ADP
admet-1474	73	86	a	a	DET
admet-1474	73	87	plain	plain	ADJ
admet-1474	73	88	paper	paper	NOUN
admet-1474	73	89	placed	place	VERB
admet-1474	73	90	below	below	ADP
admet-1474	73	91	it	it	PRON
admet-1474	73	92	)	)	PUNCT
admet-1474	73	93	and	and	CCONJ
admet-1474	73	94	allowed	allow	VERB
admet-1474	73	95	to	to	PART
admet-1474	73	96	flow	flow	VERB
admet-1474	73	97	unto	unto	ADP
admet-1474	73	98	the	the	DET
admet-1474	73	99	surface	surface	NOUN
admet-1474	73	100	of	of	ADP
admet-1474	73	101	the	the	DET
admet-1474	73	102	paper	paper	NOUN
admet-1474	73	103	freely	freely	ADV
admet-1474	73	104	.	.	PUNCT
admet-1474	74	1	the	the	DET
admet-1474	74	2	height	height	NOUN
admet-1474	74	3	(	(	PUNCT
admet-1474	74	4	h	h	NOUN
admet-1474	74	5	)	)	PUNCT
admet-1474	74	6	of	of	ADP
admet-1474	74	7	the	the	DET
admet-1474	74	8	cone	cone	NOUN
admet-1474	74	9	formed	form	VERB
admet-1474	74	10	was	be	AUX
admet-1474	74	11	noted	note	VERB
admet-1474	74	12	.	.	PUNCT
admet-1474	75	1	a	a	DET
admet-1474	75	2	circle	circle	NOUN
admet-1474	75	3	was	be	AUX
admet-1474	75	4	drawn	draw	VERB
admet-1474	75	5	around	around	ADP
admet-1474	75	6	the	the	DET
admet-1474	75	7	base	base	NOUN
admet-1474	75	8	of	of	ADP
admet-1474	75	9	the	the	DET
admet-1474	75	10	cone	cone	NOUN
admet-1474	75	11	and	and	CCONJ
admet-1474	75	12	the	the	DET
admet-1474	75	13	radius	radius	NOUN
admet-1474	75	14	(	(	PUNCT
admet-1474	75	15	r	r	NOUN
admet-1474	75	16	)	)	PUNCT
admet-1474	75	17	was	be	AUX
admet-1474	75	18	determined	determine	VERB
admet-1474	75	19	.	.	PUNCT
admet-1474	76	1	the	the	DET
admet-1474	76	2	repose	repose	NOUN
admet-1474	76	3	angle	angle	NOUN
admet-1474	76	4	,	,	PUNCT
admet-1474	76	5	θ	θ	PROPN
admet-1474	76	6	,	,	PUNCT
admet-1474	76	7	was	be	AUX
admet-1474	76	8	estimated	estimate	VERB
admet-1474	76	9	as	as	SCONJ
admet-1474	76	10	follows	follow	VERB
admet-1474	76	11	:	:	PUNCT
admet-1474	77	1	tan	tan	PROPN
admet-1474	77	2	h	h	NOUN
admet-1474	78	1	r	r	NOUN
admet-1474	78	2			PUNCT
admet-1474	78	3	1tan	1tan	ADJ
admet-1474	78	4	h	h	NOUN
admet-1474	78	5	r	r	NOUN
admet-1474	78	6			PROPN
admet-1474	78	7			NOUN
admet-1474	78	8			NOUN
admet-1474	78	9			PROPN
admet-1474	78	10			PROPN
admet-1474	78	11			PROPN
admet-1474	78	12			PROPN
admet-1474	78	13			PROPN
admet-1474	78	14			PROPN
admet-1474	78	15	drug	drug	NOUN
admet-1474	78	16	content	content	NOUN
admet-1474	78	17	levodopa	levodopa	NOUN
admet-1474	78	18	and	and	CCONJ
admet-1474	78	19	carbidopa	carbidopa	NOUN
admet-1474	78	20	in	in	ADP
admet-1474	78	21	the	the	DET
admet-1474	78	22	various	various	ADJ
admet-1474	78	23	formulations	formulation	NOUN
admet-1474	78	24	were	be	AUX
admet-1474	78	25	determined	determine	VERB
admet-1474	78	26	according	accord	VERB
admet-1474	78	27	to	to	ADP
admet-1474	78	28	a	a	DET
admet-1474	78	29	validated	validate	VERB
admet-1474	78	30	hplc	hplc	NOUN
admet-1474	78	31	method	method	NOUN
admet-1474	78	32	previously	previously	ADV
admet-1474	78	33	described	describe	VERB
admet-1474	78	34	by	by	ADP
admet-1474	78	35	shohreh	shohreh	NOUN
admet-1474	78	36	et	et	PROPN
admet-1474	78	37	al	al	PROPN
admet-1474	78	38	.	.	PUNCT
admet-1474	79	1	[	[	X
admet-1474	79	2	18	18	NUM
admet-1474	79	3	]	]	PUNCT
admet-1474	79	4	,	,	PUNCT
admet-1474	79	5	with	with	ADP
admet-1474	79	6	minor	minor	ADJ
admet-1474	79	7	modifications	modification	NOUN
admet-1474	79	8	.	.	PUNCT
admet-1474	80	1	the	the	DET
admet-1474	80	2	chromatographic	chromatographic	ADJ
admet-1474	80	3	procedure	procedure	NOUN
admet-1474	80	4	was	be	AUX
admet-1474	80	5	carried	carry	VERB
admet-1474	80	6	out	out	ADP
admet-1474	80	7	using	use	VERB
admet-1474	80	8	agilent	agilent	PROPN
admet-1474	80	9	technologies	technology	NOUN
admet-1474	80	10	system	system	NOUN
admet-1474	80	11	1100	1100	NUM
admet-1474	80	12	(	(	PUNCT
admet-1474	80	13	santa	santa	PROPN
admet-1474	80	14	clara	clara	PROPN
admet-1474	80	15	,	,	PUNCT
admet-1474	80	16	ca	ca	PROPN
admet-1474	80	17	,	,	PUNCT
admet-1474	80	18	usa	usa	PROPN
admet-1474	80	19	)	)	PUNCT
admet-1474	80	20	equipped	equip	VERB
admet-1474	80	21	with	with	ADP
admet-1474	80	22	a	a	DET
admet-1474	80	23	uv	uv	NOUN
admet-1474	80	24	/	/	SYM
admet-1474	80	25	visible	visible	ADJ
admet-1474	80	26	detector	detector	NOUN
admet-1474	80	27	(	(	PUNCT
admet-1474	80	28	detection	detection	NOUN
admet-1474	80	29	wavelength	wavelength	NOUN
admet-1474	80	30	of	of	ADP
admet-1474	80	31	280	280	NUM
admet-1474	80	32	nm	nm	NOUN
admet-1474	80	33	)	)	PUNCT
admet-1474	80	34	.	.	PUNCT
admet-1474	81	1	a	a	DET
admet-1474	81	2	stainless	stainless	ADJ
admet-1474	81	3	-	-	PUNCT
admet-1474	81	4	steel	steel	NOUN
admet-1474	81	5	column	column	NOUN
admet-1474	81	6	with	with	ADP
admet-1474	81	7	stationary	stationary	ADJ
admet-1474	81	8	phase	phase	NOUN
admet-1474	81	9	tskgel	tskgel	PROPN
admet-1474	81	10	ods	ods	PROPN
admet-1474	81	11	c18	c18	PROPN
admet-1474	81	12	maintained	maintain	VERB
admet-1474	81	13	at	at	ADP
admet-1474	81	14	30	30	NUM
admet-1474	81	15	°	°	NUM
admet-1474	81	16	c	c	NOUN
admet-1474	81	17	was	be	AUX
admet-1474	81	18	used	use	VERB
admet-1474	81	19	.	.	PUNCT
admet-1474	82	1	the	the	DET
admet-1474	82	2	mobile	mobile	ADJ
admet-1474	82	3	phase	phase	NOUN
admet-1474	82	4	comprised	comprise	VERB
admet-1474	82	5	10	10	NUM
admet-1474	82	6	mm	mm	NOUN
admet-1474	82	7	phosphate	phosphate	NOUN
admet-1474	82	8	buffer	buffer	NOUN
admet-1474	82	9	(	(	PUNCT
admet-1474	82	10	ph	ph	NOUN
admet-1474	82	11	of	of	ADP
admet-1474	82	12	4.0	4.0	NUM
admet-1474	82	13	)	)	PUNCT
admet-1474	82	14	and	and	CCONJ
admet-1474	82	15	methanol	methanol	NOUN
admet-1474	82	16	(	(	PUNCT
admet-1474	82	17	90:10	90:10	NUM
admet-1474	82	18	v	v	NOUN
admet-1474	82	19	/	/	SYM
admet-1474	82	20	v	v	NOUN
admet-1474	82	21	)	)	PUNCT
admet-1474	82	22	.	.	PUNCT
admet-1474	83	1	the	the	DET
admet-1474	83	2	flow	flow	NOUN
admet-1474	83	3	rate	rate	NOUN
admet-1474	83	4	of	of	ADP
admet-1474	83	5	the	the	DET
admet-1474	83	6	mobile	mobile	ADJ
admet-1474	83	7	phase	phase	NOUN
admet-1474	83	8	was	be	AUX
admet-1474	83	9	maintained	maintain	VERB
admet-1474	83	10	at	at	ADP
admet-1474	83	11	0.6	0.6	NUM
admet-1474	83	12	ml	ml	NOUN
admet-1474	83	13	/	/	SYM
admet-1474	83	14	min	min	NOUN
admet-1474	83	15	with	with	ADP
admet-1474	83	16	a	a	DET
admet-1474	83	17	run	run	ADJ
admet-1474	83	18	time	time	NOUN
admet-1474	83	19	of	of	ADP
admet-1474	83	20	10	10	NUM
admet-1474	83	21	min	min	NOUN
admet-1474	83	22	.	.	PUNCT
admet-1474	84	1	the	the	DET
admet-1474	84	2	injection	injection	NOUN
admet-1474	84	3	volume	volume	NOUN
admet-1474	84	4	was	be	AUX
admet-1474	84	5	set	set	VERB
admet-1474	84	6	to	to	ADP
admet-1474	84	7	20	20	NUM
admet-1474	84	8	µl	µl	NOUN
admet-1474	84	9	.	.	PUNCT
admet-1474	85	1	all	all	DET
admet-1474	85	2	solvents	solvent	NOUN
admet-1474	85	3	used	use	VERB
admet-1474	85	4	were	be	AUX
admet-1474	85	5	of	of	ADP
admet-1474	85	6	hplc	hplc	NOUN
admet-1474	85	7	grade	grade	NOUN
admet-1474	85	8	and	and	CCONJ
admet-1474	85	9	were	be	AUX
admet-1474	85	10	filtered	filter	VERB
admet-1474	85	11	with	with	ADP
admet-1474	85	12	0.45	0.45	NUM
admet-1474	85	13	µm	µm	ADP
admet-1474	85	14	filters	filter	NOUN
admet-1474	85	15	prior	prior	ADV
admet-1474	85	16	to	to	ADP
admet-1474	85	17	use	use	NOUN
admet-1474	85	18	.	.	PUNCT
admet-1474	86	1	preparation	preparation	NOUN
admet-1474	86	2	of	of	ADP
admet-1474	86	3	stock	stock	NOUN
admet-1474	86	4	and	and	CCONJ
admet-1474	86	5	working	working	NOUN
admet-1474	86	6	solutions	solution	NOUN
admet-1474	86	7	stock	stock	NOUN
admet-1474	86	8	standard	standard	ADJ
admet-1474	86	9	solutions	solution	NOUN
admet-1474	86	10	(	(	PUNCT
admet-1474	86	11	1	1	NUM
admet-1474	86	12	mg	mg	NUM
admet-1474	86	13	/	/	SYM
admet-1474	86	14	ml	ml	NOUN
admet-1474	86	15	)	)	PUNCT
admet-1474	86	16	of	of	ADP
admet-1474	86	17	levodopa	levodopa	NOUN
admet-1474	86	18	and	and	CCONJ
admet-1474	86	19	carbidopa	carbidopa	NOUN
admet-1474	86	20	were	be	AUX
admet-1474	86	21	prepared	prepare	VERB
admet-1474	86	22	fresh	fresh	ADJ
admet-1474	86	23	daily	daily	ADV
admet-1474	86	24	in	in	ADP
admet-1474	86	25	1000	1000	NUM
admet-1474	86	26	µl	µl	ADP
admet-1474	86	27	distilled	distil	VERB
admet-1474	86	28	water	water	NOUN
admet-1474	86	29	separately	separately	ADV
admet-1474	86	30	.	.	PUNCT
admet-1474	87	1	the	the	DET
admet-1474	87	2	respective	respective	ADJ
admet-1474	87	3	solutions	solution	NOUN
admet-1474	87	4	were	be	AUX
admet-1474	87	5	vortex	vortex	NOUN
admet-1474	87	6	-	-	PUNCT
admet-1474	87	7	mixed	mixed	ADJ
admet-1474	87	8	for	for	ADP
admet-1474	87	9	10	10	NUM
admet-1474	87	10	min	min	NOUN
admet-1474	87	11	and	and	CCONJ
admet-1474	87	12	sonicated	sonicate	VERB
admet-1474	87	13	for	for	ADP
admet-1474	87	14	20	20	NUM
admet-1474	87	15	min	min	NOUN
admet-1474	87	16	to	to	PART
admet-1474	87	17	completely	completely	ADV
admet-1474	87	18	dissolve	dissolve	VERB
admet-1474	87	19	the	the	DET
admet-1474	87	20	drugs	drug	NOUN
admet-1474	87	21	.	.	PUNCT
admet-1474	88	1	a	a	DET
admet-1474	88	2	working	work	VERB
admet-1474	88	3	standard	standard	ADJ
admet-1474	88	4	solutions	solution	NOUN
admet-1474	88	5	of	of	ADP
admet-1474	88	6	200	200	NUM
admet-1474	88	7	µg	µg	NOUN
admet-1474	88	8	/	/	SYM
admet-1474	88	9	ml	ml	NOUN
admet-1474	88	10	of	of	ADP
admet-1474	88	11	each	each	DET
admet-1474	88	12	stock	stock	NOUN
admet-1474	88	13	were	be	AUX
admet-1474	88	14	prepared	prepare	VERB
admet-1474	88	15	.	.	PUNCT
admet-1474	89	1	two	two	NUM
admet-1474	89	2	-	-	ADJ
admet-1474	89	3	fold	fold	ADJ
admet-1474	89	4	serial	serial	ADJ
admet-1474	89	5	dilutions	dilution	NOUN
admet-1474	89	6	of	of	ADP
admet-1474	89	7	each	each	DET
admet-1474	89	8	working	work	VERB
admet-1474	89	9	standard	standard	ADJ
admet-1474	89	10	solutions	solution	NOUN
admet-1474	89	11	were	be	AUX
admet-1474	89	12	prepared	prepare	VERB
admet-1474	89	13	to	to	PART
admet-1474	89	14	give	give	VERB
admet-1474	89	15	eight	eight	NUM
admet-1474	89	16	standard	standard	ADJ
admet-1474	89	17	solutions	solution	NOUN
admet-1474	89	18	with	with	ADP
admet-1474	89	19	concentrations	concentration	NOUN
admet-1474	89	20	100	100	NUM
admet-1474	89	21	,	,	PUNCT
admet-1474	89	22	50	50	NUM
admet-1474	89	23	,	,	PUNCT
admet-1474	89	24	25	25	NUM
admet-1474	89	25	,	,	PUNCT
admet-1474	89	26	12.5	12.5	NUM
admet-1474	89	27	,	,	PUNCT
admet-1474	89	28	6.25	6.25	NUM
admet-1474	89	29	,	,	PUNCT
admet-1474	89	30	3.125	3.125	NUM
admet-1474	89	31	,	,	PUNCT
admet-1474	89	32	1.56	1.56	NUM
admet-1474	89	33	and	and	CCONJ
admet-1474	89	34	0.78	0.78	NUM
admet-1474	89	35	µg	µg	NOUN
admet-1474	89	36	/	/	SYM
admet-1474	89	37	ml	ml	NOUN
admet-1474	89	38	.	.	PUNCT
admet-1474	90	1	the	the	DET
admet-1474	90	2	same	same	ADJ
admet-1474	90	3	volume	volume	NOUN
admet-1474	90	4	of	of	ADP
admet-1474	90	5	standard	standard	ADJ
admet-1474	90	6	solutions	solution	NOUN
admet-1474	90	7	of	of	ADP
admet-1474	90	8	levodopa	levodopa	NOUN
admet-1474	90	9	and	and	CCONJ
admet-1474	90	10	carbidopa	carbidopa	NOUN
admet-1474	90	11	were	be	AUX
admet-1474	90	12	mixed	mixed	ADJ
admet-1474	90	13	,	,	PUNCT
admet-1474	90	14	giving	give	VERB
admet-1474	90	15	standard	standard	ADJ
admet-1474	90	16	working	work	VERB
admet-1474	90	17	solutions	solution	NOUN
admet-1474	90	18	100	100	NUM
admet-1474	90	19	,	,	PUNCT
admet-1474	90	20	50	50	NUM
admet-1474	90	21	,	,	PUNCT
admet-1474	90	22	25	25	NUM
admet-1474	90	23	,	,	PUNCT
admet-1474	90	24	12.5	12.5	NUM
admet-1474	90	25	,	,	PUNCT
admet-1474	90	26	6.25	6.25	NUM
admet-1474	90	27	,	,	PUNCT
admet-1474	90	28	3.125	3.125	NUM
admet-1474	90	29	,	,	PUNCT
admet-1474	90	30	1.56	1.56	NUM
admet-1474	90	31	,	,	PUNCT
admet-1474	90	32	0.78	0.78	NUM
admet-1474	90	33	and	and	CCONJ
admet-1474	90	34	0.39	0.39	NUM
admet-1474	90	35	µg	µg	NOUN
admet-1474	90	36	/	/	SYM
admet-1474	90	37	ml	ml	NOUN
admet-1474	90	38	.	.	NOUN
admet-1474	91	1	twenty	twenty	NUM
admet-1474	91	2	microliters	microliter	NOUN
admet-1474	91	3	(	(	PUNCT
admet-1474	91	4	20	20	NUM
admet-1474	91	5	µl	µl	NOUN
admet-1474	91	6	)	)	PUNCT
admet-1474	91	7	of	of	ADP
admet-1474	91	8	the	the	DET
admet-1474	91	9	standard	standard	ADJ
admet-1474	91	10	working	work	VERB
admet-1474	91	11	solutions	solution	NOUN
admet-1474	91	12	were	be	AUX
admet-1474	91	13	injected	inject	VERB
admet-1474	91	14	into	into	ADP
admet-1474	91	15	the	the	DET
admet-1474	91	16	hplc	hplc	NOUN
admet-1474	91	17	system	system	NOUN
admet-1474	91	18	.	.	PUNCT
admet-1474	92	1	the	the	DET
admet-1474	92	2	retention	retention	NOUN
admet-1474	92	3	times	time	NOUN
admet-1474	92	4	and	and	CCONJ
admet-1474	92	5	peak	peak	NOUN
admet-1474	92	6	areas	area	NOUN
admet-1474	92	7	for	for	ADP
admet-1474	92	8	levodopa	levodopa	NOUN
admet-1474	92	9	and	and	CCONJ
admet-1474	92	10	carbidopa	carbidopa	NOUN
admet-1474	92	11	were	be	AUX
admet-1474	92	12	determined	determine	VERB
admet-1474	92	13	and	and	CCONJ
admet-1474	92	14	calibration	calibration	NOUN
admet-1474	92	15	curves	curve	NOUN
admet-1474	92	16	were	be	AUX
admet-1474	92	17	obtained	obtain	VERB
admet-1474	92	18	.	.	PUNCT
admet-1474	93	1	levodopa	levodopa	NOUN
admet-1474	93	2	and	and	CCONJ
admet-1474	93	3	carbidopa	carbidopa	NOUN
admet-1474	93	4	showed	show	VERB
admet-1474	93	5	good	good	ADJ
admet-1474	93	6	resolution	resolution	NOUN
admet-1474	93	7	and	and	CCONJ
admet-1474	93	8	retention	retention	NOUN
admet-1474	93	9	times	time	NOUN
admet-1474	93	10	(	(	PUNCT
admet-1474	93	11	3.7	3.7	NUM
admet-1474	93	12	and	and	CCONJ
admet-1474	93	13	5.5	5.5	NUM
admet-1474	93	14	min	min	NOUN
admet-1474	93	15	,	,	PUNCT
admet-1474	93	16	respectively	respectively	ADV
admet-1474	93	17	)	)	PUNCT
admet-1474	93	18	.	.	PUNCT
admet-1474	94	1	admet	admet	PROPN
admet-1474	94	2	&	&	CCONJ
admet-1474	94	3	dmpk	dmpk	PROPN
admet-1474	94	4	11(1	11(1	NUM
admet-1474	94	5	)	)	PUNCT
admet-1474	94	6	(	(	PUNCT
admet-1474	94	7	2023	2023	NUM
admet-1474	94	8	)	)	PUNCT
admet-1474	94	9	97	97	NUM
admet-1474	94	10	-	-	SYM
admet-1474	94	11	115	115	NUM
admet-1474	94	12	evaluation	evaluation	NOUN
admet-1474	94	13	of	of	ADP
admet-1474	94	14	re	re	ADJ
admet-1474	94	15	-	-	ADJ
admet-1474	94	16	formulated	formulate	VERB
admet-1474	94	17	levodopa	levodopa	NOUN
admet-1474	94	18	and	and	CCONJ
admet-1474	94	19	carbidopa	carbidopa	NOUN
admet-1474	94	20	doi	doi	NOUN
admet-1474	94	21	:	:	PUNCT
admet-1474	94	22	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	94	23	101	101	NUM
admet-1474	94	24	validation	validation	NOUN
admet-1474	94	25	of	of	ADP
admet-1474	94	26	the	the	DET
admet-1474	94	27	method	method	NOUN
admet-1474	94	28	the	the	DET
admet-1474	94	29	analytical	analytical	ADJ
admet-1474	94	30	method	method	NOUN
admet-1474	94	31	was	be	AUX
admet-1474	94	32	validated	validate	VERB
admet-1474	94	33	according	accord	VERB
admet-1474	94	34	to	to	ADP
admet-1474	94	35	the	the	DET
admet-1474	94	36	international	international	ADJ
admet-1474	94	37	conference	conference	NOUN
admet-1474	94	38	on	on	ADP
admet-1474	94	39	harmonization	harmonization	NOUN
admet-1474	94	40	(	(	PUNCT
admet-1474	94	41	ich	ich	NOUN
admet-1474	94	42	)	)	PUNCT
admet-1474	94	43	guidelines	guideline	NOUN
admet-1474	94	44	.	.	PUNCT
admet-1474	95	1	linearity	linearity	NOUN
admet-1474	95	2	the	the	DET
admet-1474	95	3	linearity	linearity	NOUN
admet-1474	95	4	was	be	AUX
admet-1474	95	5	evaluated	evaluate	VERB
admet-1474	95	6	by	by	ADP
admet-1474	95	7	analyzing	analyze	VERB
admet-1474	95	8	different	different	ADJ
admet-1474	95	9	concentrations	concentration	NOUN
admet-1474	95	10	of	of	ADP
admet-1474	95	11	the	the	DET
admet-1474	95	12	standard	standard	ADJ
admet-1474	95	13	solutions	solution	NOUN
admet-1474	95	14	.	.	PUNCT
admet-1474	96	1	the	the	DET
admet-1474	96	2	calibration	calibration	NOUN
admet-1474	96	3	curve	curve	NOUN
admet-1474	96	4	was	be	AUX
admet-1474	96	5	constructed	construct	VERB
admet-1474	96	6	for	for	ADP
admet-1474	96	7	levodopa	levodopa	NOUN
admet-1474	96	8	and	and	CCONJ
admet-1474	96	9	carbidopa	carbidopa	ADV
admet-1474	96	10	by	by	ADP
admet-1474	96	11	plotting	plot	VERB
admet-1474	96	12	the	the	DET
admet-1474	96	13	average	average	ADJ
admet-1474	96	14	peak	peak	NOUN
admet-1474	96	15	area	area	NOUN
admet-1474	96	16	against	against	ADP
admet-1474	96	17	concentration	concentration	NOUN
admet-1474	96	18	,	,	PUNCT
admet-1474	96	19	and	and	CCONJ
admet-1474	96	20	a	a	DET
admet-1474	96	21	regression	regression	NOUN
admet-1474	96	22	equation	equation	NOUN
admet-1474	96	23	was	be	AUX
admet-1474	96	24	found	find	VERB
admet-1474	96	25	from	from	ADP
admet-1474	96	26	the	the	DET
admet-1474	96	27	plot	plot	NOUN
admet-1474	96	28	.	.	PUNCT
admet-1474	97	1	the	the	DET
admet-1474	97	2	slope	slope	NOUN
admet-1474	97	3	of	of	ADP
admet-1474	97	4	the	the	DET
admet-1474	97	5	regression	regression	NOUN
admet-1474	97	6	line	line	NOUN
admet-1474	97	7	and	and	CCONJ
admet-1474	97	8	values	value	NOUN
admet-1474	97	9	of	of	ADP
admet-1474	97	10	the	the	DET
admet-1474	97	11	correlation	correlation	NOUN
admet-1474	97	12	coefficient	coefficient	NOUN
admet-1474	97	13	(	(	PUNCT
admet-1474	97	14	r2	r2	PROPN
admet-1474	97	15	)	)	PUNCT
admet-1474	97	16	for	for	ADP
admet-1474	97	17	each	each	DET
admet-1474	97	18	standard	standard	ADJ
admet-1474	97	19	curve	curve	NOUN
admet-1474	97	20	were	be	AUX
admet-1474	97	21	obtained	obtain	VERB
admet-1474	97	22	by	by	ADP
admet-1474	97	23	using	use	VERB
admet-1474	97	24	ms	ms	PROPN
admet-1474	97	25	excel	excel	PROPN
admet-1474	97	26	software	software	NOUN
admet-1474	97	27	.	.	PUNCT
admet-1474	98	1	determination	determination	NOUN
admet-1474	98	2	of	of	ADP
admet-1474	98	3	loq	loq	PROPN
admet-1474	98	4	and	and	CCONJ
admet-1474	98	5	lod	lod	PROPN
admet-1474	98	6	limits	limit	NOUN
admet-1474	98	7	of	of	ADP
admet-1474	98	8	detection	detection	NOUN
admet-1474	98	9	(	(	PUNCT
admet-1474	98	10	lod	lod	PROPN
admet-1474	98	11	)	)	PUNCT
admet-1474	98	12	and	and	CCONJ
admet-1474	98	13	limits	limit	NOUN
admet-1474	98	14	of	of	ADP
admet-1474	98	15	quantification	quantification	NOUN
admet-1474	98	16	(	(	PUNCT
admet-1474	98	17	loq	loq	PROPN
admet-1474	98	18	)	)	PUNCT
admet-1474	98	19	were	be	AUX
admet-1474	98	20	calculated	calculate	VERB
admet-1474	98	21	for	for	ADP
admet-1474	98	22	each	each	DET
admet-1474	98	23	standard	standard	ADJ
admet-1474	98	24	solution	solution	NOUN
admet-1474	98	25	in	in	ADP
admet-1474	98	26	triplicates	triplicate	NOUN
admet-1474	98	27	.	.	PUNCT
admet-1474	99	1	the	the	DET
admet-1474	99	2	mean	mean	NOUN
admet-1474	99	3	of	of	ADP
admet-1474	99	4	the	the	DET
admet-1474	99	5	slope	slope	NOUN
admet-1474	99	6	(	(	PUNCT
admet-1474	99	7	s	s	NOUN
admet-1474	99	8	)	)	PUNCT
admet-1474	99	9	and	and	CCONJ
admet-1474	99	10	standard	standard	ADJ
admet-1474	99	11	deviation	deviation	NOUN
admet-1474	99	12	of	of	ADP
admet-1474	99	13	the	the	DET
admet-1474	99	14	response	response	NOUN
admet-1474	99	15	(	(	PUNCT
admet-1474	99	16	σ	σ	NOUN
admet-1474	99	17	)	)	PUNCT
admet-1474	99	18	were	be	AUX
admet-1474	99	19	calculated	calculate	VERB
admet-1474	99	20	from	from	ADP
admet-1474	99	21	the	the	DET
admet-1474	99	22	standard	standard	ADJ
admet-1474	99	23	curve	curve	NOUN
admet-1474	99	24	of	of	ADP
admet-1474	99	25	three	three	NUM
admet-1474	99	26	replicates	replicate	NOUN
admet-1474	99	27	.	.	PUNCT
admet-1474	100	1	lod	lod	PROPN
admet-1474	100	2	and	and	CCONJ
admet-1474	100	3	loq	loq	PROPN
admet-1474	100	4	were	be	AUX
admet-1474	100	5	calculated	calculate	VERB
admet-1474	100	6	with	with	ADP
admet-1474	100	7	the	the	DET
admet-1474	100	8	following	follow	VERB
admet-1474	100	9	equations	equation	NOUN
admet-1474	100	10	:	:	PUNCT
admet-1474	100	11	3.3lod	3.3lod	NUM
admet-1474	100	12	s	s	PART
admet-1474	100	13			PROPN
admet-1474	100	14			NUM
admet-1474	100	15	10loq	10loq	NOUN
admet-1474	100	16	s	s	PART
admet-1474	100	17			PROPN
admet-1474	100	18			NUM
admet-1474	100	19	precision	precision	NOUN
admet-1474	100	20	the	the	DET
admet-1474	100	21	precision	precision	NOUN
admet-1474	100	22	of	of	ADP
admet-1474	100	23	the	the	DET
admet-1474	100	24	method	method	NOUN
admet-1474	100	25	was	be	AUX
admet-1474	100	26	tested	test	VERB
admet-1474	100	27	by	by	ADP
admet-1474	100	28	injecting	inject	VERB
admet-1474	100	29	a	a	DET
admet-1474	100	30	standard	standard	ADJ
admet-1474	100	31	solution	solution	NOUN
admet-1474	100	32	of	of	ADP
admet-1474	100	33	levodopa	levodopa	NOUN
admet-1474	100	34	and	and	CCONJ
admet-1474	100	35	carbidopa	carbidopa	NOUN
admet-1474	100	36	(	(	PUNCT
admet-1474	100	37	12.5	12.5	NUM
admet-1474	100	38	μg	μg	NOUN
admet-1474	100	39	/	/	SYM
admet-1474	100	40	ml	ml	NOUN
admet-1474	100	41	)	)	PUNCT
admet-1474	100	42	six	six	NUM
admet-1474	100	43	times	time	NOUN
admet-1474	100	44	.	.	PUNCT
admet-1474	101	1	peak	peak	NOUN
admet-1474	101	2	areas	area	NOUN
admet-1474	101	3	were	be	AUX
admet-1474	101	4	determined	determine	VERB
admet-1474	101	5	,	,	PUNCT
admet-1474	101	6	compared	compare	VERB
admet-1474	101	7	and	and	CCONJ
admet-1474	101	8	expressed	express	VERB
admet-1474	101	9	as	as	ADP
admet-1474	101	10	percentage	percentage	NOUN
admet-1474	101	11	relative	relative	ADJ
admet-1474	101	12	standard	standard	ADJ
admet-1474	101	13	deviation	deviation	NOUN
admet-1474	101	14	(	(	PUNCT
admet-1474	101	15	%	%	NOUN
admet-1474	101	16	rsd	rsd	NOUN
admet-1474	101	17	):	):	PUNCT
admet-1474	101	18	100	100	NUM
admet-1474	101	19	sd	sd	ADP
admet-1474	101	20	rsd	rsd	NOUN
admet-1474	101	21	x	x	NOUN
admet-1474	101	22	mean	mean	VERB
admet-1474	101	23			NUM
admet-1474	101	24	selectivity	selectivity	NOUN
admet-1474	101	25	selectivity	selectivity	NOUN
admet-1474	101	26	was	be	AUX
admet-1474	101	27	evaluated	evaluate	VERB
admet-1474	101	28	by	by	ADP
admet-1474	101	29	processing	processing	NOUN
admet-1474	101	30	and	and	CCONJ
admet-1474	101	31	analyzing	analyze	VERB
admet-1474	101	32	drug	drug	NOUN
admet-1474	101	33	-	-	PUNCT
admet-1474	101	34	free	free	ADJ
admet-1474	101	35	samples	sample	NOUN
admet-1474	101	36	to	to	PART
admet-1474	101	37	ensure	ensure	VERB
admet-1474	101	38	the	the	DET
admet-1474	101	39	absence	absence	NOUN
admet-1474	101	40	of	of	ADP
admet-1474	101	41	compounds	compound	NOUN
admet-1474	101	42	with	with	ADP
admet-1474	101	43	the	the	DET
admet-1474	101	44	same	same	ADJ
admet-1474	101	45	retention	retention	NOUN
admet-1474	101	46	times	time	NOUN
admet-1474	101	47	at	at	ADP
admet-1474	101	48	the	the	DET
admet-1474	101	49	analytes	analyte	NOUN
admet-1474	101	50	of	of	ADP
admet-1474	101	51	interest	interest	NOUN
admet-1474	101	52	.	.	PUNCT
admet-1474	102	1	no	no	DET
admet-1474	102	2	peaks	peak	NOUN
admet-1474	102	3	were	be	AUX
admet-1474	102	4	observed	observe	VERB
admet-1474	102	5	at	at	ADP
admet-1474	102	6	the	the	DET
admet-1474	102	7	retention	retention	NOUN
admet-1474	102	8	times	time	NOUN
admet-1474	102	9	of	of	ADP
admet-1474	102	10	levodopa	levodopa	NOUN
admet-1474	102	11	and	and	CCONJ
admet-1474	102	12	carbidopa	carbidopa	NOUN
admet-1474	102	13	.	.	PUNCT
admet-1474	103	1	robustness	robustness	VERB
admet-1474	103	2	the	the	DET
admet-1474	103	3	robustness	robustness	NOUN
admet-1474	103	4	of	of	ADP
admet-1474	103	5	the	the	DET
admet-1474	103	6	procedure	procedure	NOUN
admet-1474	103	7	was	be	AUX
admet-1474	103	8	demonstrated	demonstrate	VERB
admet-1474	103	9	by	by	ADP
admet-1474	103	10	intentionally	intentionally	ADV
admet-1474	103	11	modifying	modify	VERB
admet-1474	103	12	the	the	DET
admet-1474	103	13	chromatographic	chromatographic	ADJ
admet-1474	103	14	conditions	condition	NOUN
admet-1474	103	15	.	.	PUNCT
admet-1474	104	1	the	the	DET
admet-1474	104	2	mobile	mobile	ADJ
admet-1474	104	3	phase	phase	NOUN
admet-1474	104	4	flow	flow	NOUN
admet-1474	104	5	rate	rate	NOUN
admet-1474	104	6	was	be	AUX
admet-1474	104	7	altered	alter	VERB
admet-1474	104	8	from	from	ADP
admet-1474	104	9	0.6	0.6	NUM
admet-1474	104	10	to	to	ADP
admet-1474	104	11	0.5	0.5	NUM
admet-1474	104	12	ml	ml	NOUN
admet-1474	104	13	/	/	SYM
admet-1474	104	14	min	min	NOUN
admet-1474	104	15	and	and	CCONJ
admet-1474	104	16	from	from	ADP
admet-1474	104	17	0.6	0.6	NUM
admet-1474	104	18	to	to	ADP
admet-1474	104	19	0.7	0.7	NUM
admet-1474	104	20	ml	ml	NOUN
admet-1474	104	21	/	/	SYM
admet-1474	104	22	min	min	NOUN
admet-1474	104	23	.	.	PUNCT
admet-1474	105	1	the	the	DET
admet-1474	105	2	column	column	NOUN
admet-1474	105	3	temperature	temperature	NOUN
admet-1474	105	4	was	be	AUX
admet-1474	105	5	varied	varied	ADJ
admet-1474	105	6	from	from	ADP
admet-1474	105	7	30	30	NUM
admet-1474	105	8	°	°	NOUN
admet-1474	105	9	c	c	NOUN
admet-1474	105	10	to	to	ADP
admet-1474	105	11	35	35	NUM
admet-1474	105	12	°	°	NOUN
admet-1474	105	13	c	c	NOUN
admet-1474	105	14	,	,	PUNCT
admet-1474	105	15	as	as	ADV
admet-1474	105	16	well	well	ADV
admet-1474	105	17	as	as	ADP
admet-1474	105	18	the	the	DET
admet-1474	105	19	wavelength	wavelength	NOUN
admet-1474	105	20	from	from	ADP
admet-1474	105	21	280	280	NUM
admet-1474	105	22	to	to	PART
admet-1474	105	23	282	282	NUM
admet-1474	105	24	nm	nm	NOUN
admet-1474	105	25	.	.	PUNCT
admet-1474	106	1	the	the	DET
admet-1474	106	2	percentage	percentage	NOUN
admet-1474	106	3	recovery	recovery	NOUN
admet-1474	106	4	of	of	ADP
admet-1474	106	5	robustness	robustness	NOUN
admet-1474	106	6	testing	testing	NOUN
admet-1474	106	7	under	under	ADP
admet-1474	106	8	the	the	DET
admet-1474	106	9	altered	alter	VERB
admet-1474	106	10	conditions	condition	NOUN
admet-1474	106	11	was	be	AUX
admet-1474	106	12	calculated	calculate	VERB
admet-1474	106	13	in	in	ADP
admet-1474	106	14	all	all	DET
admet-1474	106	15	cases	case	NOUN
admet-1474	106	16	.	.	PUNCT
admet-1474	107	1	content	content	NOUN
admet-1474	107	2	analysis	analysis	NOUN
admet-1474	107	3	the	the	DET
admet-1474	107	4	actual	actual	ADJ
admet-1474	107	5	drug	drug	NOUN
admet-1474	107	6	content	content	NOUN
admet-1474	107	7	of	of	ADP
admet-1474	107	8	the	the	DET
admet-1474	107	9	chitosan	chitosan	NOUN
admet-1474	107	10	-	-	PUNCT
admet-1474	107	11	pectin	pectin	NOUN
admet-1474	107	12	-	-	PUNCT
admet-1474	107	13	based	base	VERB
admet-1474	107	14	multiparticulate	multiparticulate	ADJ
admet-1474	107	15	matrix	matrix	NOUN
admet-1474	107	16	was	be	AUX
admet-1474	107	17	determined	determine	VERB
admet-1474	107	18	by	by	ADP
admet-1474	107	19	weighing	weigh	VERB
admet-1474	107	20	and	and	CCONJ
admet-1474	107	21	dissolving	dissolve	VERB
admet-1474	107	22	1	1	NUM
admet-1474	107	23	mg	mg	ADP
admet-1474	107	24	of	of	ADP
admet-1474	107	25	the	the	DET
admet-1474	107	26	formulation	formulation	NOUN
admet-1474	107	27	(	(	PUNCT
admet-1474	107	28	in	in	ADP
admet-1474	107	29	triplicate	triplicate	NOUN
admet-1474	107	30	)	)	PUNCT
admet-1474	107	31	in	in	ADP
admet-1474	107	32	1	1	NUM
admet-1474	107	33	ml	ml	NOUN
admet-1474	107	34	of	of	ADP
admet-1474	107	35	distilled	distil	VERB
admet-1474	107	36	water	water	NOUN
admet-1474	107	37	.	.	PUNCT
admet-1474	108	1	this	this	PRON
admet-1474	108	2	was	be	AUX
admet-1474	108	3	then	then	ADV
admet-1474	108	4	vortex	vortex	NOUN
admet-1474	108	5	-	-	PUNCT
admet-1474	108	6	mixed	mixed	ADJ
admet-1474	108	7	for	for	ADP
admet-1474	108	8	10	10	NUM
admet-1474	108	9	min	min	NOUN
admet-1474	108	10	,	,	PUNCT
admet-1474	108	11	and	and	CCONJ
admet-1474	108	12	sonicated	sonicate	VERB
admet-1474	108	13	for	for	ADP
admet-1474	108	14	10	10	NUM
admet-1474	108	15	min	min	NOUN
admet-1474	108	16	.	.	PROPN
admet-1474	108	17	afterwards	afterwards	ADV
admet-1474	108	18	,	,	PUNCT
admet-1474	108	19	the	the	DET
admet-1474	108	20	mixture	mixture	NOUN
admet-1474	108	21	was	be	AUX
admet-1474	108	22	centrifuged	centrifuge	VERB
admet-1474	108	23	at	at	ADP
admet-1474	108	24	10,000	10,000	NUM
admet-1474	108	25	rpm	rpm	NOUN
admet-1474	108	26	for	for	ADP
admet-1474	108	27	10	10	NUM
admet-1474	108	28	min	min	NOUN
admet-1474	108	29	.	.	PUNCT
admet-1474	109	1	a	a	DET
admet-1474	109	2	volume	volume	NOUN
admet-1474	109	3	of	of	ADP
admet-1474	109	4	500	500	NUM
admet-1474	109	5	µl	µl	NOUN
admet-1474	109	6	of	of	ADP
admet-1474	109	7	the	the	DET
admet-1474	109	8	supernatant	supernatant	NOUN
admet-1474	109	9	was	be	AUX
admet-1474	109	10	pipetted	pipette	VERB
admet-1474	109	11	into	into	ADP
admet-1474	109	12	the	the	DET
admet-1474	109	13	hplc	hplc	NOUN
admet-1474	109	14	auto	auto	NOUN
admet-1474	109	15	-	-	PUNCT
admet-1474	109	16	sampler	sampler	NOUN
admet-1474	109	17	and	and	CCONJ
admet-1474	109	18	analysed	analyse	VERB
admet-1474	109	19	by	by	ADP
admet-1474	109	20	hplc	hplc	NOUN
admet-1474	109	21	(	(	PUNCT
admet-1474	109	22	as	as	SCONJ
admet-1474	109	23	previously	previously	ADV
admet-1474	109	24	described	describe	VERB
admet-1474	109	25	)	)	PUNCT
admet-1474	109	26	.	.	PUNCT
admet-1474	110	1	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	110	2	emelia	emelia	PROPN
admet-1474	110	3	priscilla	priscilla	PROPN
admet-1474	110	4	imbeah	imbeah	PROPN
admet-1474	110	5	et	et	PROPN
admet-1474	110	6	al	al	PROPN
admet-1474	110	7	.	.	PROPN
admet-1474	110	8	admet	admet	PROPN
admet-1474	110	9	&	&	CCONJ
admet-1474	110	10	dmpk	dmpk	PROPN
admet-1474	110	11	11(1	11(1	NUM
admet-1474	110	12	)	)	PUNCT
admet-1474	110	13	(	(	PUNCT
admet-1474	110	14	2023	2023	NUM
admet-1474	110	15	)	)	PUNCT
admet-1474	110	16	97	97	NUM
admet-1474	110	17	-	-	SYM
admet-1474	110	18	115	115	NUM
admet-1474	110	19	102	102	NUM
admet-1474	110	20	in	in	ADP
admet-1474	110	21	vitro	vitro	X
admet-1474	110	22	drug	drug	NOUN
admet-1474	110	23	release	release	NOUN
admet-1474	110	24	drug	drug	NOUN
admet-1474	110	25	dissolution	dissolution	NOUN
admet-1474	110	26	was	be	AUX
admet-1474	110	27	conducted	conduct	VERB
admet-1474	110	28	in	in	ADP
admet-1474	110	29	phosphate	phosphate	ADJ
admet-1474	110	30	buffer	buffer	NOUN
admet-1474	110	31	(	(	PUNCT
admet-1474	110	32	ph	ph	NOUN
admet-1474	110	33	6.8	6.8	NUM
admet-1474	110	34	)	)	PUNCT
admet-1474	110	35	to	to	PART
admet-1474	110	36	simulate	simulate	VERB
admet-1474	110	37	the	the	DET
admet-1474	110	38	gastrointestinal	gastrointestinal	ADJ
admet-1474	110	39	environment	environment	NOUN
admet-1474	110	40	,	,	PUNCT
admet-1474	110	41	as	as	SCONJ
admet-1474	110	42	previously	previously	ADV
admet-1474	110	43	described	describe	VERB
admet-1474	110	44	[	[	X
admet-1474	110	45	10,19	10,19	NUM
admet-1474	110	46	]	]	X
admet-1474	110	47	.	.	PUNCT
admet-1474	111	1	samples	sample	NOUN
admet-1474	111	2	of	of	ADP
admet-1474	111	3	the	the	DET
admet-1474	111	4	various	various	ADJ
admet-1474	111	5	chitosan	chitosan	NOUN
admet-1474	111	6	-	-	PUNCT
admet-1474	111	7	pectin	pectin	NOUN
admet-1474	111	8	-	-	PUNCT
admet-1474	111	9	based	base	VERB
admet-1474	111	10	formulations	formulation	NOUN
admet-1474	111	11	(	(	PUNCT
admet-1474	111	12	f1	f1	NOUN
admet-1474	111	13	,	,	PUNCT
admet-1474	111	14	f2	f2	PROPN
admet-1474	111	15	,	,	PUNCT
admet-1474	111	16	f3	f3	ADJ
admet-1474	111	17	,	,	PUNCT
admet-1474	111	18	f4	f4	ADJ
admet-1474	111	19	and	and	CCONJ
admet-1474	111	20	f5	f5	NOUN
admet-1474	111	21	)	)	PUNCT
admet-1474	111	22	were	be	AUX
admet-1474	111	23	tested	test	VERB
admet-1474	111	24	in	in	ADP
admet-1474	111	25	vitro	vitro	X
admet-1474	111	26	.	.	PUNCT
admet-1474	112	1	samples	sample	NOUN
admet-1474	112	2	(	(	PUNCT
admet-1474	112	3	5	5	NUM
admet-1474	112	4	ml	ml	NOUN
admet-1474	112	5	)	)	PUNCT
admet-1474	112	6	were	be	AUX
admet-1474	112	7	drawn	draw	VERB
admet-1474	112	8	from	from	ADP
admet-1474	112	9	baskets	basket	NOUN
admet-1474	112	10	of	of	ADP
admet-1474	112	11	usp	usp	NOUN
admet-1474	112	12	dissolution	dissolution	NOUN
admet-1474	112	13	apparatus	apparatus	NOUN
admet-1474	112	14	at	at	ADP
admet-1474	112	15	the	the	DET
admet-1474	112	16	following	following	ADJ
admet-1474	112	17	time	time	NOUN
admet-1474	112	18	points	point	NOUN
admet-1474	112	19	:	:	PUNCT
admet-1474	112	20	0	0	NUM
admet-1474	112	21	,	,	PUNCT
admet-1474	112	22	0.5	0.5	NUM
admet-1474	112	23	,	,	PUNCT
admet-1474	112	24	1	1	NUM
admet-1474	112	25	,	,	PUNCT
admet-1474	112	26	2	2	NUM
admet-1474	112	27	,	,	PUNCT
admet-1474	112	28	4	4	NUM
admet-1474	112	29	,	,	PUNCT
admet-1474	112	30	8	8	NUM
admet-1474	112	31	,	,	PUNCT
admet-1474	112	32	12	12	NUM
admet-1474	112	33	and	and	CCONJ
admet-1474	112	34	24	24	NUM
admet-1474	112	35	hr	hr	NOUN
admet-1474	112	36	,	,	PUNCT
admet-1474	112	37	for	for	ADP
admet-1474	112	38	analysis	analysis	NOUN
admet-1474	112	39	.	.	PUNCT
admet-1474	113	1	these	these	PRON
admet-1474	113	2	were	be	AUX
admet-1474	113	3	immediately	immediately	ADV
admet-1474	113	4	replaced	replace	VERB
admet-1474	113	5	with	with	ADP
admet-1474	113	6	an	an	DET
admet-1474	113	7	equal	equal	ADJ
admet-1474	113	8	volume	volume	NOUN
admet-1474	113	9	of	of	ADP
admet-1474	113	10	fresh	fresh	ADJ
admet-1474	113	11	phosphate	phosphate	NOUN
admet-1474	113	12	buffer	buffer	NOUN
admet-1474	113	13	(	(	PUNCT
admet-1474	113	14	37	37	NUM
admet-1474	113	15	°	°	NOUN
admet-1474	113	16	c	c	NOUN
admet-1474	113	17	)	)	PUNCT
admet-1474	113	18	.	.	PUNCT
admet-1474	114	1	the	the	DET
admet-1474	114	2	release	release	NOUN
admet-1474	114	3	of	of	ADP
admet-1474	114	4	levodopa	levodopa	NOUN
admet-1474	114	5	and	and	CCONJ
admet-1474	114	6	carbidopa	carbidopa	NOUN
admet-1474	114	7	was	be	AUX
admet-1474	114	8	determined	determine	VERB
admet-1474	114	9	by	by	ADP
admet-1474	114	10	assaying	assay	VERB
admet-1474	114	11	levels	level	NOUN
admet-1474	114	12	using	use	VERB
admet-1474	114	13	hplc	hplc	NOUN
admet-1474	114	14	,	,	PUNCT
admet-1474	114	15	as	as	SCONJ
admet-1474	114	16	previously	previously	ADV
admet-1474	114	17	described	describe	VERB
admet-1474	114	18	by	by	ADP
admet-1474	114	19	shohreh	shohreh	NOUN
admet-1474	114	20	et	et	PROPN
admet-1474	114	21	al	al	PROPN
admet-1474	114	22	.	.	PUNCT
admet-1474	115	1	[	[	X
admet-1474	115	2	18	18	NUM
admet-1474	115	3	]	]	PUNCT
admet-1474	115	4	.	.	PUNCT
admet-1474	116	1	triplicate	triplicate	VERB
admet-1474	116	2	measurements	measurement	NOUN
admet-1474	116	3	were	be	AUX
admet-1474	116	4	performed	perform	VERB
admet-1474	116	5	.	.	PUNCT
admet-1474	117	1	in	in	ADP
admet-1474	117	2	vitro	vitro	X
admet-1474	117	3	drug	drug	NOUN
admet-1474	117	4	release	release	NOUN
admet-1474	117	5	was	be	AUX
admet-1474	117	6	also	also	ADV
admet-1474	117	7	done	do	VERB
admet-1474	117	8	in	in	ADP
admet-1474	117	9	a	a	DET
admet-1474	117	10	phosphate	phosphate	ADJ
admet-1474	117	11	buffer	buffer	NOUN
admet-1474	117	12	of	of	ADP
admet-1474	117	13	ph	ph	ADJ
admet-1474	117	14	4.5	4.5	NUM
admet-1474	117	15	(	(	PUNCT
admet-1474	117	16	for	for	SCONJ
admet-1474	117	17	optimized	optimize	VERB
admet-1474	117	18	formulations	formulation	NOUN
admet-1474	117	19	f3	f3	ADJ
admet-1474	117	20	and	and	CCONJ
admet-1474	117	21	f4	f4	NOUN
admet-1474	117	22	only	only	ADV
admet-1474	117	23	)	)	PUNCT
admet-1474	117	24	to	to	PART
admet-1474	117	25	mimic	mimic	VERB
admet-1474	117	26	the	the	DET
admet-1474	117	27	duodenum	duodenum	ADJ
admet-1474	117	28	-	-	PUNCT
admet-1474	117	29	jejunal	jejunal	ADJ
admet-1474	117	30	environment	environment	NOUN
admet-1474	117	31	where	where	SCONJ
admet-1474	117	32	absorption	absorption	NOUN
admet-1474	117	33	of	of	ADP
admet-1474	117	34	levodopa	levodopa	NOUN
admet-1474	117	35	occurs	occur	VERB
admet-1474	117	36	[	[	X
admet-1474	117	37	20,21	20,21	NUM
admet-1474	117	38	]	]	PUNCT
admet-1474	117	39	and	and	CCONJ
admet-1474	117	40	to	to	PART
admet-1474	117	41	observe	observe	VERB
admet-1474	117	42	the	the	DET
admet-1474	117	43	behavior	behavior	NOUN
admet-1474	117	44	of	of	ADP
admet-1474	117	45	the	the	DET
admet-1474	117	46	chitosan	chitosan	NOUN
admet-1474	117	47	-	-	PUNCT
admet-1474	117	48	pectin	pectin	NOUN
admet-1474	117	49	matrix	matrix	NOUN
admet-1474	117	50	in	in	ADP
admet-1474	117	51	this	this	DET
admet-1474	117	52	media	medium	NOUN
admet-1474	117	53	.	.	PUNCT
admet-1474	118	1	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	118	2	evaluation	evaluation	NOUN
admet-1474	118	3	of	of	ADP
admet-1474	118	4	new	new	ADJ
admet-1474	118	5	formulation	formulation	NOUN
admet-1474	118	6	sprague	sprague	NOUN
admet-1474	118	7	dawley	dawley	NOUN
admet-1474	118	8	(	(	PUNCT
admet-1474	118	9	sd	sd	NOUN
admet-1474	118	10	)	)	PUNCT
admet-1474	118	11	rats	rat	NOUN
admet-1474	118	12	that	that	PRON
admet-1474	118	13	were	be	AUX
admet-1474	118	14	about	about	ADV
admet-1474	118	15	seven	seven	NUM
admet-1474	118	16	weeks	week	NOUN
admet-1474	118	17	old	old	ADJ
admet-1474	118	18	and	and	CCONJ
admet-1474	118	19	weighing	weigh	VERB
admet-1474	118	20	between	between	ADP
admet-1474	118	21	180	180	NUM
admet-1474	118	22	-	-	SYM
admet-1474	118	23	200	200	NUM
admet-1474	118	24	g	g	NOUN
admet-1474	118	25	were	be	AUX
admet-1474	118	26	housed	house	VERB
admet-1474	118	27	in	in	ADP
admet-1474	118	28	an	an	DET
admet-1474	118	29	approved	approve	VERB
admet-1474	118	30	animal	animal	NOUN
admet-1474	118	31	house	house	NOUN
admet-1474	118	32	.	.	PUNCT
admet-1474	119	1	animals	animal	NOUN
admet-1474	119	2	were	be	AUX
admet-1474	119	3	kept	keep	VERB
admet-1474	119	4	at	at	ADP
admet-1474	119	5	optimal	optimal	ADJ
admet-1474	119	6	laboratory	laboratory	NOUN
admet-1474	119	7	conditions	condition	NOUN
admet-1474	119	8	,	,	PUNCT
admet-1474	119	9	which	which	PRON
admet-1474	119	10	consisted	consist	VERB
admet-1474	119	11	of	of	ADP
admet-1474	119	12	12	12	NUM
admet-1474	119	13	-	-	PUNCT
admet-1474	119	14	hour	hour	NOUN
admet-1474	119	15	lightening	lightening	NOUN
admet-1474	119	16	,	,	PUNCT
admet-1474	119	17	laboratory	laboratory	NOUN
admet-1474	119	18	temperature	temperature	NOUN
admet-1474	119	19	of	of	ADP
admet-1474	119	20	25	25	NUM
admet-1474	119	21	±	±	NUM
admet-1474	119	22	1	1	NUM
admet-1474	119	23	°	°	ADP
admet-1474	119	24	c	c	NOUN
admet-1474	119	25	,	,	PUNCT
admet-1474	119	26	and	and	CCONJ
admet-1474	119	27	humidity	humidity	NOUN
admet-1474	119	28	of	of	ADP
admet-1474	119	29	60	60	NUM
admet-1474	119	30	-	-	SYM
admet-1474	119	31	70	70	NUM
admet-1474	119	32	%	%	NOUN
admet-1474	119	33	.	.	PUNCT
admet-1474	120	1	sd	sd	NOUN
admet-1474	120	2	rats	rat	NOUN
admet-1474	120	3	were	be	AUX
admet-1474	120	4	made	make	VERB
admet-1474	120	5	to	to	PART
admet-1474	120	6	acclimatise	acclimatise	VERB
admet-1474	120	7	to	to	ADP
admet-1474	120	8	this	this	DET
admet-1474	120	9	laboratory	laboratory	NOUN
admet-1474	120	10	condition	condition	NOUN
admet-1474	120	11	for	for	ADP
admet-1474	120	12	two	two	NUM
admet-1474	120	13	weeks	week	NOUN
admet-1474	120	14	.	.	PUNCT
admet-1474	121	1	guidelines	guideline	NOUN
admet-1474	121	2	for	for	ADP
admet-1474	121	3	animal	animal	NOUN
admet-1474	121	4	use	use	NOUN
admet-1474	121	5	and	and	CCONJ
admet-1474	121	6	care[22	care[22	NOUN
admet-1474	121	7	]	]	PUNCT
admet-1474	121	8	,	,	PUNCT
admet-1474	121	9	were	be	AUX
admet-1474	121	10	adhered	adhere	VERB
admet-1474	121	11	to	to	ADP
admet-1474	121	12	throughout	throughout	ADP
admet-1474	121	13	the	the	DET
admet-1474	121	14	experiment	experiment	NOUN
admet-1474	121	15	.	.	PUNCT
admet-1474	122	1	animals	animal	NOUN
admet-1474	122	2	were	be	AUX
admet-1474	122	3	made	make	VERB
admet-1474	122	4	to	to	PART
admet-1474	122	5	fast	fast	VERB
admet-1474	122	6	overnight	overnight	ADV
admet-1474	122	7	and	and	CCONJ
admet-1474	122	8	rats	rat	NOUN
admet-1474	122	9	in	in	ADP
admet-1474	122	10	group	group	NOUN
admet-1474	122	11	1	1	NUM
admet-1474	122	12	were	be	AUX
admet-1474	122	13	administered	administer	VERB
admet-1474	122	14	an	an	DET
admet-1474	122	15	optimized	optimize	VERB
admet-1474	122	16	chitosanpectin	chitosanpectin	NOUN
admet-1474	122	17	-	-	PUNCT
admet-1474	122	18	based	base	VERB
admet-1474	122	19	matrix	matrix	NOUN
admet-1474	122	20	of	of	ADP
admet-1474	122	21	levodopa	levodopa	NOUN
admet-1474	122	22	and	and	CCONJ
admet-1474	122	23	carbidopa	carbidopa	NOUN
admet-1474	122	24	(	(	PUNCT
admet-1474	122	25	f3	f3	ADJ
admet-1474	122	26	)	)	PUNCT
admet-1474	122	27	,	,	PUNCT
admet-1474	122	28	and	and	CCONJ
admet-1474	122	29	rats	rat	NOUN
admet-1474	122	30	in	in	ADP
admet-1474	122	31	group	group	NOUN
admet-1474	122	32	2	2	NUM
admet-1474	122	33	were	be	AUX
admet-1474	122	34	given	give	VERB
admet-1474	122	35	f4	f4	PROPN
admet-1474	122	36	.	.	PUNCT
admet-1474	123	1	these	these	DET
admet-1474	123	2	two	two	NUM
admet-1474	123	3	formulations	formulation	NOUN
admet-1474	123	4	showed	show	VERB
admet-1474	123	5	better	well	ADJ
admet-1474	123	6	pharmaceutical	pharmaceutical	NOUN
admet-1474	123	7	and	and	CCONJ
admet-1474	123	8	in	in	ADP
admet-1474	123	9	vitro	vitro	X
admet-1474	123	10	kinetic	kinetic	ADJ
admet-1474	123	11	characteristics	characteristic	NOUN
admet-1474	123	12	.	.	PUNCT
admet-1474	124	1	group	group	NOUN
admet-1474	124	2	3	3	NUM
admet-1474	124	3	rats	rat	NOUN
admet-1474	124	4	received	receive	VERB
admet-1474	124	5	sinemet	sinemet	PROPN
admet-1474	124	6	®	®	PROPN
admet-1474	124	7	cr	cr	PROPN
admet-1474	124	8	(	(	PUNCT
admet-1474	124	9	merck	merck	PROPN
admet-1474	124	10	sharp	sharp	PROPN
admet-1474	124	11	&	&	CCONJ
admet-1474	124	12	dohme	dohme	PROPN
admet-1474	124	13	limited	limit	VERB
admet-1474	124	14	,	,	PUNCT
admet-1474	124	15	hertfordshire	hertfordshire	PROPN
admet-1474	124	16	uk	uk	PROPN
admet-1474	124	17	)	)	PUNCT
admet-1474	124	18	.	.	PUNCT
admet-1474	125	1	group	group	NOUN
admet-1474	125	2	4	4	NUM
admet-1474	125	3	rats	rat	NOUN
admet-1474	125	4	were	be	AUX
admet-1474	125	5	given	give	VERB
admet-1474	125	6	immediaterelease	immediaterelease	ADJ
admet-1474	125	7	powders	powder	NOUN
admet-1474	125	8	of	of	ADP
admet-1474	125	9	levodopa	levodopa	NOUN
admet-1474	125	10	and	and	CCONJ
admet-1474	125	11	carbidopa	carbidopa	NOUN
admet-1474	125	12	.	.	PUNCT
admet-1474	126	1	animals	animal	NOUN
admet-1474	126	2	in	in	ADP
admet-1474	126	3	each	each	DET
admet-1474	126	4	group	group	NOUN
admet-1474	126	5	were	be	AUX
admet-1474	126	6	given	give	VERB
admet-1474	126	7	a	a	DET
admet-1474	126	8	dose	dose	NOUN
admet-1474	126	9	of	of	ADP
admet-1474	126	10	(	(	PUNCT
admet-1474	126	11	20/5	20/5	NUM
admet-1474	126	12	mg	mg	PROPN
admet-1474	126	13	/	/	SYM
admet-1474	126	14	kg	kg	NOUN
admet-1474	126	15	)	)	PUNCT
admet-1474	126	16	of	of	ADP
admet-1474	126	17	levodopa	levodopa	NOUN
admet-1474	126	18	and	and	CCONJ
admet-1474	126	19	carbidopa	carbidopa	NOUN
admet-1474	126	20	per	per	ADP
admet-1474	126	21	os	os	NOUN
admet-1474	126	22	every	every	DET
admet-1474	126	23	12	12	NUM
admet-1474	126	24	hours	hour	NOUN
admet-1474	126	25	.	.	PUNCT
admet-1474	127	1	the	the	DET
admet-1474	127	2	multiparticulate	multiparticulate	ADJ
admet-1474	127	3	matrix	matrix	NOUN
admet-1474	127	4	formulations	formulation	NOUN
admet-1474	127	5	,	,	PUNCT
admet-1474	127	6	sinemet	sinemet	PROPN
admet-1474	127	7	®	®	PROPN
admet-1474	127	8	cr	cr	PROPN
admet-1474	127	9	and	and	CCONJ
admet-1474	127	10	the	the	DET
admet-1474	127	11	immediate	immediate	ADJ
admet-1474	127	12	release	release	NOUN
admet-1474	127	13	powders	powder	NOUN
admet-1474	127	14	were	be	AUX
admet-1474	127	15	suspended	suspend	VERB
admet-1474	127	16	in	in	ADP
admet-1474	127	17	water	water	NOUN
admet-1474	127	18	before	before	ADP
admet-1474	127	19	administration	administration	NOUN
admet-1474	127	20	(	(	PUNCT
admet-1474	127	21	via	via	ADP
admet-1474	127	22	oral	oral	ADJ
admet-1474	127	23	gavage	gavage	NOUN
admet-1474	127	24	)	)	PUNCT
admet-1474	127	25	.	.	PUNCT
admet-1474	128	1	after	after	ADP
admet-1474	128	2	the	the	DET
admet-1474	128	3	third	third	ADJ
admet-1474	128	4	dose	dose	NOUN
admet-1474	128	5	,	,	PUNCT
admet-1474	128	6	tail	tail	NOUN
admet-1474	128	7	vein	vein	ADJ
admet-1474	128	8	samples	sample	NOUN
admet-1474	128	9	were	be	AUX
admet-1474	128	10	taken	take	VERB
admet-1474	128	11	at	at	ADP
admet-1474	128	12	0.25	0.25	NUM
admet-1474	128	13	,	,	PUNCT
admet-1474	128	14	0.5	0.5	NUM
admet-1474	128	15	,	,	PUNCT
admet-1474	128	16	1	1	NUM
admet-1474	128	17	,	,	PUNCT
admet-1474	128	18	2	2	NUM
admet-1474	128	19	,	,	PUNCT
admet-1474	128	20	4	4	NUM
admet-1474	128	21	,	,	PUNCT
admet-1474	128	22	8	8	NUM
admet-1474	128	23	,	,	PUNCT
admet-1474	128	24	12	12	NUM
admet-1474	128	25	and	and	CCONJ
admet-1474	128	26	24	24	NUM
admet-1474	128	27	hr	hr	NOUN
admet-1474	128	28	into	into	ADP
admet-1474	128	29	ethylenediaminetetraacetic	ethylenediaminetetraacetic	ADJ
admet-1474	128	30	acid	acid	NOUN
admet-1474	128	31	(	(	PUNCT
admet-1474	128	32	edta	edta	NOUN
admet-1474	128	33	)	)	PUNCT
admet-1474	128	34	tubes	tube	NOUN
admet-1474	128	35	.	.	PUNCT
admet-1474	129	1	in	in	ADP
admet-1474	129	2	order	order	NOUN
admet-1474	129	3	to	to	PART
admet-1474	129	4	minimize	minimize	VERB
admet-1474	129	5	levodopa	levodopa	NOUN
admet-1474	129	6	in	in	ADP
admet-1474	129	7	blood	blood	NOUN
admet-1474	129	8	samples	sample	NOUN
admet-1474	129	9	from	from	ADP
admet-1474	129	10	undergoing	undergo	VERB
admet-1474	129	11	oxidation	oxidation	NOUN
admet-1474	129	12	,	,	PUNCT
admet-1474	129	13	25	25	NUM
admet-1474	129	14	%	%	NOUN
admet-1474	129	15	sodium	sodium	NOUN
admet-1474	129	16	metabisulfite	metabisulfite	NOUN
admet-1474	129	17	in	in	ADP
admet-1474	129	18	water	water	NOUN
admet-1474	129	19	was	be	AUX
admet-1474	129	20	prepared	prepare	VERB
admet-1474	129	21	and	and	CCONJ
admet-1474	129	22	added	add	VERB
admet-1474	129	23	to	to	ADP
admet-1474	129	24	the	the	DET
admet-1474	129	25	blood	blood	NOUN
admet-1474	129	26	in	in	ADP
admet-1474	129	27	a	a	DET
admet-1474	129	28	ratio	ratio	NOUN
admet-1474	129	29	of	of	ADP
admet-1474	129	30	1:10	1:10	NUM
admet-1474	129	31	(	(	PUNCT
admet-1474	129	32	v	v	NOUN
admet-1474	129	33	/	/	SYM
admet-1474	129	34	v	v	NOUN
admet-1474	129	35	)	)	PUNCT
admet-1474	129	36	.	.	PUNCT
admet-1474	130	1	immediately	immediately	ADV
admet-1474	130	2	,	,	PUNCT
admet-1474	130	3	samples	sample	NOUN
admet-1474	130	4	were	be	AUX
admet-1474	130	5	centrifuged	centrifuge	VERB
admet-1474	130	6	at	at	ADP
admet-1474	130	7	4,500	4,500	NUM
admet-1474	130	8	rpm	rpm	NOUN
admet-1474	130	9	for	for	ADP
admet-1474	130	10	10	10	NUM
admet-1474	130	11	min	min	NOUN
admet-1474	130	12	to	to	PART
admet-1474	130	13	obtain	obtain	VERB
admet-1474	130	14	plasma	plasma	NOUN
admet-1474	130	15	.	.	PUNCT
admet-1474	131	1	levodopa	levodopa	NOUN
admet-1474	131	2	in	in	ADP
admet-1474	131	3	plasma	plasma	NOUN
admet-1474	131	4	was	be	AUX
admet-1474	131	5	assayed	assayed	ADJ
admet-1474	131	6	using	use	VERB
admet-1474	131	7	reverse	reverse	NOUN
admet-1474	131	8	-	-	PUNCT
admet-1474	131	9	phase	phase	NOUN
admet-1474	131	10	hplc	hplc	NOUN
admet-1474	131	11	,	,	PUNCT
admet-1474	131	12	as	as	SCONJ
admet-1474	131	13	previously	previously	ADV
admet-1474	131	14	described	describe	VERB
admet-1474	131	15	by	by	ADP
admet-1474	131	16	kim	kim	PROPN
admet-1474	131	17	et	et	PROPN
admet-1474	131	18	al	al	PROPN
admet-1474	131	19	.	.	PUNCT
admet-1474	132	1	[	[	X
admet-1474	132	2	23	23	NUM
admet-1474	132	3	]	]	PUNCT
admet-1474	132	4	.	.	PUNCT
admet-1474	133	1	a	a	DET
admet-1474	133	2	stock	stock	NOUN
admet-1474	133	3	of	of	ADP
admet-1474	133	4	the	the	DET
admet-1474	133	5	internal	internal	ADJ
admet-1474	133	6	standard	standard	ADJ
admet-1474	133	7	solution	solution	NOUN
admet-1474	133	8	was	be	AUX
admet-1474	133	9	prepared	prepare	VERB
admet-1474	133	10	by	by	ADP
admet-1474	133	11	dissolving	dissolve	VERB
admet-1474	133	12	20	20	NUM
admet-1474	133	13	mg	mg	NOUN
admet-1474	133	14	methyldopa	methyldopa	ADV
admet-1474	133	15	in	in	ADP
admet-1474	133	16	15	15	NUM
admet-1474	133	17	ml	ml	ADV
admet-1474	133	18	deionized	deionize	VERB
admet-1474	133	19	water	water	NOUN
admet-1474	133	20	to	to	PART
admet-1474	133	21	obtain	obtain	VERB
admet-1474	133	22	a	a	DET
admet-1474	133	23	concentration	concentration	NOUN
admet-1474	133	24	of	of	ADP
admet-1474	133	25	1.3	1.3	NUM
admet-1474	133	26	mg	mg	NOUN
admet-1474	133	27	/	/	SYM
admet-1474	133	28	ml	ml	NOUN
admet-1474	133	29	.	.	PUNCT
admet-1474	134	1	levodopa	levodopa	NOUN
admet-1474	134	2	was	be	AUX
admet-1474	134	3	extracted	extract	VERB
admet-1474	134	4	from	from	ADP
admet-1474	134	5	plasma	plasma	NOUN
admet-1474	134	6	using	use	VERB
admet-1474	134	7	protein	protein	NOUN
admet-1474	134	8	precipitation	precipitation	NOUN
admet-1474	134	9	with	with	ADP
admet-1474	134	10	perchloric	perchloric	ADJ
admet-1474	134	11	acid	acid	NOUN
admet-1474	134	12	.	.	PUNCT
admet-1474	135	1	to	to	ADP
admet-1474	135	2	100	100	NUM
admet-1474	135	3	l	l	PROPN
admet-1474	135	4	of	of	ADP
admet-1474	135	5	rat	rat	NOUN
admet-1474	135	6	plasma	plasma	NOUN
admet-1474	135	7	,	,	PUNCT
admet-1474	135	8	50	50	NUM
admet-1474	135	9	l	l	NOUN
admet-1474	135	10	of	of	ADP
admet-1474	135	11	0.1	0.1	NUM
admet-1474	135	12	m	m	PROPN
admet-1474	135	13	perchloric	perchloric	ADJ
admet-1474	135	14	acid	acid	PROPN
admet-1474	135	15	was	be	AUX
admet-1474	135	16	added	add	VERB
admet-1474	135	17	.	.	PUNCT
admet-1474	136	1	the	the	DET
admet-1474	136	2	mixture	mixture	NOUN
admet-1474	136	3	was	be	AUX
admet-1474	136	4	vortexed	vortexe	VERB
admet-1474	136	5	for	for	ADP
admet-1474	136	6	2	2	NUM
admet-1474	136	7	min	min	NOUN
admet-1474	136	8	.	.	PROPN
admet-1474	136	9	afterwards	afterwards	ADV
admet-1474	136	10	,	,	PUNCT
admet-1474	136	11	centrifugation	centrifugation	NOUN
admet-1474	136	12	was	be	AUX
admet-1474	136	13	done	do	VERB
admet-1474	136	14	at	at	ADP
admet-1474	136	15	10,000	10,000	NUM
admet-1474	136	16	rpm	rpm	NOUN
admet-1474	136	17	and	and	CCONJ
admet-1474	136	18	the	the	DET
admet-1474	136	19	supernatant	supernatant	NOUN
admet-1474	136	20	analysed	analyse	VERB
admet-1474	136	21	by	by	ADP
admet-1474	136	22	hplc	hplc	PROPN
admet-1474	136	23	.	.	PUNCT
admet-1474	137	1	the	the	DET
admet-1474	137	2	hplc	hplc	NOUN
admet-1474	137	3	method	method	NOUN
admet-1474	137	4	showed	show	VERB
admet-1474	137	5	good	good	ADJ
admet-1474	137	6	linearity	linearity	NOUN
admet-1474	137	7	(	(	PUNCT
admet-1474	137	8	0.00	0.00	NUM
admet-1474	137	9	–	–	PUNCT
admet-1474	137	10	25.00	25.00	NUM
admet-1474	137	11	μg	μg	NOUN
admet-1474	137	12	/	/	SYM
admet-1474	137	13	ml	ml	NOUN
admet-1474	137	14	)	)	PUNCT
admet-1474	137	15	with	with	ADP
admet-1474	137	16	a	a	DET
admet-1474	137	17	correlation	correlation	NOUN
admet-1474	137	18	coefficient	coefficient	NOUN
admet-1474	137	19	(	(	PUNCT
admet-1474	137	20	r2	r2	PROPN
admet-1474	137	21	)	)	PUNCT
admet-1474	137	22	of	of	ADP
admet-1474	137	23	0.9997	0.9997	NUM
admet-1474	137	24	for	for	ADP
admet-1474	137	25	the	the	DET
admet-1474	137	26	calibration	calibration	NOUN
admet-1474	137	27	curve	curve	NOUN
admet-1474	137	28	of	of	ADP
admet-1474	137	29	levodopa	levodopa	NOUN
admet-1474	137	30	.	.	PUNCT
admet-1474	138	1	ethical	ethical	ADJ
admet-1474	138	2	considerations	consideration	NOUN
admet-1474	138	3	the	the	DET
admet-1474	138	4	ethics	ethic	NOUN
admet-1474	138	5	and	and	CCONJ
admet-1474	138	6	protocol	protocol	NOUN
admet-1474	138	7	review	review	NOUN
admet-1474	138	8	committee	committee	NOUN
admet-1474	138	9	,	,	PUNCT
admet-1474	138	10	college	college	NOUN
admet-1474	138	11	of	of	ADP
admet-1474	138	12	health	health	PROPN
admet-1474	138	13	sciences	sciences	PROPN
admet-1474	138	14	,	,	PUNCT
admet-1474	138	15	university	university	NOUN
admet-1474	138	16	of	of	ADP
admet-1474	138	17	ghana	ghana	PROPN
admet-1474	138	18	,	,	PUNCT
admet-1474	138	19	approved	approve	VERB
admet-1474	138	20	this	this	DET
admet-1474	138	21	study	study	NOUN
admet-1474	138	22	.	.	PUNCT
admet-1474	139	1	the	the	DET
admet-1474	139	2	protocol	protocol	NOUN
admet-1474	139	3	identification	identification	NOUN
admet-1474	139	4	number	number	NOUN
admet-1474	139	5	is	be	AUX
admet-1474	139	6	chs	ch	NOUN
admet-1474	139	7	-	-	PUNCT
admet-1474	139	8	et	et	NOUN
admet-1474	139	9	/	/	SYM
admet-1474	139	10	m.5	m.5	X
admet-1474	139	11	–	–	PUNCT
admet-1474	139	12	4.4/2020	4.4/2020	NUM
admet-1474	139	13	–	–	PUNCT
admet-1474	139	14	2021	2021	NUM
admet-1474	139	15	.	.	PUNCT
admet-1474	140	1	data	datum	NOUN
admet-1474	140	2	analysis	analysis	NOUN
admet-1474	140	3	data	datum	NOUN
admet-1474	140	4	were	be	AUX
admet-1474	140	5	expressed	express	VERB
admet-1474	140	6	as	as	ADP
admet-1474	140	7	mean	mean	ADJ
admet-1474	140	8	with	with	ADP
admet-1474	140	9	standard	standard	ADJ
admet-1474	140	10	deviation	deviation	NOUN
admet-1474	140	11	.	.	PUNCT
admet-1474	141	1	the	the	DET
admet-1474	141	2	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	141	3	parameters	parameter	NOUN
admet-1474	141	4	of	of	ADP
admet-1474	141	5	levodopa	levodopa	NOUN
admet-1474	141	6	in	in	ADP
admet-1474	141	7	admet	admet	PROPN
admet-1474	141	8	&	&	CCONJ
admet-1474	141	9	dmpk	dmpk	PROPN
admet-1474	141	10	11(1	11(1	NUM
admet-1474	141	11	)	)	PUNCT
admet-1474	141	12	(	(	PUNCT
admet-1474	141	13	2023	2023	NUM
admet-1474	141	14	)	)	PUNCT
admet-1474	141	15	97	97	NUM
admet-1474	141	16	-	-	SYM
admet-1474	141	17	115	115	NUM
admet-1474	141	18	evaluation	evaluation	NOUN
admet-1474	141	19	of	of	ADP
admet-1474	141	20	re	re	ADJ
admet-1474	141	21	-	-	ADJ
admet-1474	141	22	formulated	formulate	VERB
admet-1474	141	23	levodopa	levodopa	NOUN
admet-1474	141	24	and	and	CCONJ
admet-1474	141	25	carbidopa	carbidopa	NOUN
admet-1474	141	26	doi	doi	NOUN
admet-1474	141	27	:	:	PUNCT
admet-1474	141	28	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	141	29	103	103	NUM
admet-1474	141	30	the	the	DET
admet-1474	141	31	treatment	treatment	NOUN
admet-1474	141	32	groups	group	NOUN
admet-1474	141	33	were	be	AUX
admet-1474	141	34	determined	determine	VERB
admet-1474	141	35	by	by	ADP
admet-1474	141	36	non	non	ADJ
admet-1474	141	37	-	-	ADJ
admet-1474	141	38	compartmental	compartmental	ADJ
admet-1474	141	39	analysis	analysis	NOUN
admet-1474	141	40	.	.	PUNCT
admet-1474	142	1	inferential	inferential	ADJ
admet-1474	142	2	statistics	statistic	NOUN
admet-1474	142	3	;	;	PUNCT
admet-1474	142	4	one	one	NUM
admet-1474	142	5	-	-	PUNCT
admet-1474	142	6	way	way	NOUN
admet-1474	142	7	analysis	analysis	NOUN
admet-1474	142	8	of	of	ADP
admet-1474	142	9	variance	variance	NOUN
admet-1474	142	10	(	(	PUNCT
admet-1474	142	11	anova	anova	PROPN
admet-1474	142	12	)	)	PUNCT
admet-1474	142	13	followed	follow	VERB
admet-1474	142	14	by	by	ADP
admet-1474	142	15	tukey	tukey	PROPN
admet-1474	142	16	’s	’s	PART
admet-1474	142	17	post	post	X
admet-1474	142	18	hoc	hoc	X
admet-1474	142	19	multiple	multiple	ADJ
admet-1474	142	20	comparison	comparison	NOUN
admet-1474	142	21	test	test	NOUN
admet-1474	142	22	were	be	AUX
admet-1474	142	23	used	use	VERB
admet-1474	142	24	to	to	PART
admet-1474	142	25	compare	compare	VERB
admet-1474	142	26	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	142	27	parameters	parameter	NOUN
admet-1474	142	28	.	.	PUNCT
admet-1474	143	1	plots	plot	NOUN
admet-1474	143	2	were	be	AUX
admet-1474	143	3	done	do	VERB
admet-1474	143	4	in	in	ADP
admet-1474	143	5	graphpad	graphpad	NOUN
admet-1474	143	6	prism	prism	NOUN
admet-1474	143	7	7.0	7.0	NUM
admet-1474	143	8	(	(	PUNCT
admet-1474	143	9	san	san	PROPN
admet-1474	143	10	diego	diego	PROPN
admet-1474	143	11	,	,	PUNCT
admet-1474	143	12	california	california	PROPN
admet-1474	143	13	)	)	PUNCT
admet-1474	143	14	and	and	CCONJ
admet-1474	143	15	excel	excel	VERB
admet-1474	143	16	2013	2013	NUM
admet-1474	143	17	.	.	PUNCT
admet-1474	144	1	p	p	NOUN
admet-1474	144	2	value	value	NOUN
admet-1474	144	3	less	less	ADJ
admet-1474	144	4	than	than	ADP
admet-1474	144	5	0.05	0.05	NUM
admet-1474	144	6	was	be	AUX
admet-1474	144	7	deemed	deem	VERB
admet-1474	144	8	statistically	statistically	ADV
admet-1474	144	9	significant	significant	ADJ
admet-1474	144	10	.	.	PUNCT
admet-1474	145	1	results	result	NOUN
admet-1474	145	2	and	and	CCONJ
admet-1474	145	3	discussion	discussion	NOUN
admet-1474	145	4	ftir	ftir	VERB
admet-1474	145	5	analysis	analysis	NOUN
admet-1474	145	6	of	of	ADP
admet-1474	145	7	cph	cph	PROPN
admet-1474	145	8	pectin	pectin	NOUN
admet-1474	145	9	the	the	DET
admet-1474	145	10	yield	yield	NOUN
admet-1474	145	11	of	of	ADP
admet-1474	145	12	the	the	DET
admet-1474	145	13	hot	hot	ADJ
admet-1474	145	14	water	water	NOUN
admet-1474	145	15	-	-	PUNCT
admet-1474	145	16	soluble	soluble	ADJ
admet-1474	145	17	pectin	pectin	NOUN
admet-1474	145	18	from	from	ADP
admet-1474	145	19	cph	cph	PROPN
admet-1474	145	20	was	be	AUX
admet-1474	145	21	7.91	7.91	NUM
admet-1474	145	22	%	%	NOUN
admet-1474	145	23	.	.	PUNCT
admet-1474	146	1	infra	infra	NOUN
admet-1474	146	2	-	-	PUNCT
admet-1474	146	3	red	red	ADJ
admet-1474	146	4	spectrum	spectrum	NOUN
admet-1474	146	5	of	of	ADP
admet-1474	146	6	cph	cph	PROPN
admet-1474	146	7	pectin	pectin	NOUN
admet-1474	146	8	(	(	PUNCT
admet-1474	146	9	figure	figure	NOUN
admet-1474	146	10	1	1	NUM
admet-1474	146	11	)	)	PUNCT
admet-1474	146	12	showed	show	VERB
admet-1474	146	13	broad	broad	ADJ
admet-1474	146	14	absorption	absorption	NOUN
admet-1474	146	15	bands	band	NOUN
admet-1474	146	16	at	at	ADP
admet-1474	146	17	3280	3280	NUM
admet-1474	146	18	cm-1	cm-1	NOUN
admet-1474	146	19	,	,	PUNCT
admet-1474	146	20	2932	2932	NUM
admet-1474	146	21	cm-1	cm-1	NOUN
admet-1474	146	22	,	,	PUNCT
admet-1474	146	23	1735	1735	NUM
admet-1474	146	24	cm-1	cm-1	NOUN
admet-1474	146	25	and	and	CCONJ
admet-1474	146	26	1596	1596	NUM
admet-1474	146	27	cm-1	cm-1	NOUN
admet-1474	146	28	.	.	PUNCT
admet-1474	147	1	other	other	ADJ
admet-1474	147	2	absorption	absorption	NOUN
admet-1474	147	3	bands	band	NOUN
admet-1474	147	4	were	be	AUX
admet-1474	147	5	observed	observe	VERB
admet-1474	147	6	between	between	ADP
admet-1474	147	7	and	and	CCONJ
admet-1474	147	8	1500	1500	NUM
admet-1474	147	9	cm-1	cm-1	NOUN
admet-1474	147	10	and	and	CCONJ
admet-1474	147	11	1428	1428	NUM
admet-1474	147	12	cm−1	cm−1	NOUN
admet-1474	147	13	.	.	PUNCT
admet-1474	148	1	figure	figure	NOUN
admet-1474	148	2	1	1	NUM
admet-1474	148	3	.	.	PUNCT
admet-1474	148	4	ftir	ftir	PROPN
admet-1474	148	5	spectrum	spectrum	PROPN
admet-1474	148	6	of	of	ADP
admet-1474	148	7	cph	cph	PROPN
admet-1474	148	8	pectin	pectin	PROPN
admet-1474	148	9	ftir	ftir	PROPN
admet-1474	148	10	–	–	PUNCT
admet-1474	148	11	drug	drug	NOUN
admet-1474	148	12	-	-	PUNCT
admet-1474	148	13	excipient	excipient	NOUN
admet-1474	148	14	compatibility	compatibility	NOUN
admet-1474	148	15	study	study	VERB
admet-1474	148	16	the	the	DET
admet-1474	148	17	ftir	ftir	PROPN
admet-1474	148	18	spectra	spectra	PROPN
admet-1474	148	19	of	of	ADP
admet-1474	148	20	pure	pure	ADJ
admet-1474	148	21	levodopa	levodopa	NOUN
admet-1474	148	22	,	,	PUNCT
admet-1474	148	23	pure	pure	ADJ
admet-1474	148	24	carbidopa	carbidopa	NOUN
admet-1474	148	25	,	,	PUNCT
admet-1474	148	26	chitosan	chitosan	NOUN
admet-1474	148	27	,	,	PUNCT
admet-1474	148	28	cph	cph	PROPN
admet-1474	148	29	pectin	pectin	NOUN
admet-1474	148	30	and	and	CCONJ
admet-1474	148	31	the	the	DET
admet-1474	148	32	two	two	NUM
admet-1474	148	33	optimized	optimize	VERB
admet-1474	148	34	formulations	formulation	NOUN
admet-1474	148	35	,	,	PUNCT
admet-1474	148	36	f3	f3	NOUN
admet-1474	148	37	and	and	CCONJ
admet-1474	148	38	f4	f4	PROPN
admet-1474	148	39	,	,	PUNCT
admet-1474	148	40	were	be	AUX
admet-1474	148	41	obtained	obtain	VERB
admet-1474	148	42	and	and	CCONJ
admet-1474	148	43	superimposed	superimpose	VERB
admet-1474	148	44	.	.	PUNCT
admet-1474	149	1	as	as	SCONJ
admet-1474	149	2	shown	show	VERB
admet-1474	149	3	in	in	ADP
admet-1474	149	4	figure	figure	NOUN
admet-1474	149	5	2	2	NUM
admet-1474	149	6	,	,	PUNCT
admet-1474	149	7	the	the	DET
admet-1474	149	8	characteristic	characteristic	ADJ
admet-1474	149	9	peaks	peak	NOUN
admet-1474	149	10	of	of	ADP
admet-1474	149	11	levodopa	levodopa	NOUN
admet-1474	149	12	and	and	CCONJ
admet-1474	149	13	carbidopa	carbidopa	NOUN
admet-1474	149	14	were	be	AUX
admet-1474	149	15	retained	retain	VERB
admet-1474	149	16	in	in	ADP
admet-1474	149	17	the	the	DET
admet-1474	149	18	chitosan	chitosan	NOUN
admet-1474	149	19	-	-	PUNCT
admet-1474	149	20	pectin	pectin	NOUN
admet-1474	149	21	-	-	PUNCT
admet-1474	149	22	based	base	VERB
admet-1474	149	23	formulations	formulation	NOUN
admet-1474	149	24	(	(	PUNCT
admet-1474	149	25	optimized	optimize	VERB
admet-1474	149	26	formulations	formulation	NOUN
admet-1474	149	27	f3	f3	PROPN
admet-1474	149	28	and	and	CCONJ
admet-1474	149	29	f4	f4	NUM
admet-1474	149	30	)	)	PUNCT
admet-1474	149	31	.	.	PUNCT
admet-1474	150	1	flow	flow	NOUN
admet-1474	150	2	and	and	CCONJ
admet-1474	150	3	precompression	precompression	NOUN
admet-1474	150	4	parameters	parameter	NOUN
admet-1474	150	5	carr	carr	PROPN
admet-1474	150	6	’s	’s	PART
admet-1474	150	7	compressibility	compressibility	PROPN
admet-1474	150	8	index	index	NOUN
admet-1474	150	9	,	,	PUNCT
admet-1474	150	10	bulk	bulk	NOUN
admet-1474	150	11	and	and	CCONJ
admet-1474	150	12	tapped	tap	VERB
admet-1474	150	13	densities	density	NOUN
admet-1474	150	14	,	,	PUNCT
admet-1474	150	15	hausner	hausner	NOUN
admet-1474	150	16	ratio	ratio	NOUN
admet-1474	150	17	and	and	CCONJ
admet-1474	150	18	angle	angle	NOUN
admet-1474	150	19	of	of	ADP
admet-1474	150	20	repose	repose	NOUN
admet-1474	150	21	of	of	ADP
admet-1474	150	22	the	the	DET
admet-1474	150	23	various	various	ADJ
admet-1474	150	24	chitosan	chitosan	NOUN
admet-1474	150	25	-	-	PUNCT
admet-1474	150	26	pectin	pectin	NOUN
admet-1474	150	27	-	-	PUNCT
admet-1474	150	28	based	base	VERB
admet-1474	150	29	formulations	formulation	NOUN
admet-1474	150	30	were	be	AUX
admet-1474	150	31	determined	determine	VERB
admet-1474	150	32	.	.	PUNCT
admet-1474	151	1	the	the	DET
admet-1474	151	2	results	result	NOUN
admet-1474	151	3	are	be	AUX
admet-1474	151	4	shown	show	VERB
admet-1474	151	5	in	in	ADP
admet-1474	151	6	table	table	NOUN
admet-1474	151	7	2	2	NUM
admet-1474	151	8	.	.	PUNCT
admet-1474	152	1	all	all	DET
admet-1474	152	2	the	the	DET
admet-1474	152	3	formulations	formulation	NOUN
admet-1474	152	4	had	have	VERB
admet-1474	152	5	satisfactory	satisfactory	ADJ
admet-1474	152	6	flow	flow	NOUN
admet-1474	152	7	properties	property	NOUN
admet-1474	152	8	.	.	PUNCT
admet-1474	153	1	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	153	2	emelia	emelia	PROPN
admet-1474	153	3	priscilla	priscilla	PROPN
admet-1474	153	4	imbeah	imbeah	PROPN
admet-1474	153	5	et	et	PROPN
admet-1474	153	6	al	al	PROPN
admet-1474	153	7	.	.	PROPN
admet-1474	153	8	admet	admet	PROPN
admet-1474	153	9	&	&	CCONJ
admet-1474	153	10	dmpk	dmpk	PROPN
admet-1474	153	11	11(1	11(1	NUM
admet-1474	153	12	)	)	PUNCT
admet-1474	153	13	(	(	PUNCT
admet-1474	153	14	2023	2023	NUM
admet-1474	153	15	)	)	PUNCT
admet-1474	153	16	97	97	NUM
admet-1474	153	17	-	-	SYM
admet-1474	153	18	115	115	NUM
admet-1474	153	19	104	104	NUM
admet-1474	153	20	figure	figure	NOUN
admet-1474	153	21	2	2	NUM
admet-1474	153	22	.	.	PUNCT
admet-1474	153	23	ftir	ftir	PROPN
admet-1474	153	24	spectra	spectra	PROPN
admet-1474	153	25	of	of	ADP
admet-1474	153	26	levodopa	levodopa	NOUN
admet-1474	153	27	,	,	PUNCT
admet-1474	153	28	carbidopa	carbidopa	ADV
admet-1474	153	29	,	,	PUNCT
admet-1474	153	30	cph	cph	PROPN
admet-1474	153	31	pectin	pectin	PROPN
admet-1474	153	32	,	,	PUNCT
admet-1474	153	33	chitosan	chitosan	NOUN
admet-1474	153	34	and	and	CCONJ
admet-1474	153	35	optimized	optimize	VERB
admet-1474	153	36	formulations	formulation	NOUN
admet-1474	153	37	(	(	PUNCT
admet-1474	153	38	f3	f3	ADJ
admet-1474	153	39	and	and	CCONJ
admet-1474	153	40	f4	f4	ADJ
admet-1474	153	41	)	)	PUNCT
admet-1474	153	42	table	table	NOUN
admet-1474	153	43	2	2	NUM
admet-1474	153	44	.	.	PUNCT
admet-1474	153	45	flow	flow	NOUN
admet-1474	153	46	properties	property	NOUN
admet-1474	153	47	of	of	ADP
admet-1474	153	48	chitosan	chitosan	NOUN
admet-1474	153	49	-	-	PUNCT
admet-1474	153	50	pectin	pectin	NOUN
admet-1474	153	51	-	-	PUNCT
admet-1474	153	52	ased	ase	VERB
admet-1474	153	53	formulations	formulation	NOUN
admet-1474	153	54	formulation	formulation	VERB
admet-1474	153	55	bulk	bulk	ADJ
admet-1474	153	56	density	density	NOUN
admet-1474	153	57	(	(	PUNCT
admet-1474	153	58	kg	kg	NOUN
admet-1474	153	59	/	/	SYM
admet-1474	153	60	m3	m3	PROPN
admet-1474	153	61	)	)	PUNCT
admet-1474	153	62	tapped	tap	VERB
admet-1474	153	63	density	density	NOUN
admet-1474	153	64	(	(	PUNCT
admet-1474	153	65	kg	kg	NOUN
admet-1474	153	66	/	/	SYM
admet-1474	153	67	m3	m3	PROPN
admet-1474	153	68	)	)	PUNCT
admet-1474	153	69	hausner	hausner	NOUN
admet-1474	153	70	ratio	ratio	PROPN
admet-1474	153	71	carr	carr	PROPN
admet-1474	153	72	's	's	PART
admet-1474	153	73	index	index	NOUN
admet-1474	153	74	angle	angle	NOUN
admet-1474	153	75	of	of	ADP
admet-1474	153	76	repose	repose	NOUN
admet-1474	153	77	(	(	PUNCT
admet-1474	153	78	°	°	NOUN
admet-1474	153	79	)	)	PUNCT
admet-1474	153	80	f1	f1	NOUN
admet-1474	153	81	566.04	566.04	NUM
admet-1474	153	82	697.67	697.67	NUM
admet-1474	153	83	1.23	1.23	NUM
admet-1474	153	84	18.87	18.87	NUM
admet-1474	153	85	27.15	27.15	NUM
admet-1474	153	86	f2	f2	PROPN
admet-1474	153	87	545.45	545.45	NUM
admet-1474	153	88	750.00	750.00	NUM
admet-1474	153	89	1.38	1.38	NUM
admet-1474	153	90	27.27	27.27	NUM
admet-1474	153	91	23.5	23.5	NUM
admet-1474	153	92	f3	f3	NOUN
admet-1474	153	93	612.24	612.24	NUM
admet-1474	153	94	714.29	714.29	NUM
admet-1474	153	95	1.17	1.17	NUM
admet-1474	153	96	14.29	14.29	NUM
admet-1474	153	97	24.64	24.64	NUM
admet-1474	153	98	f4	f4	PROPN
admet-1474	153	99	588.24	588.24	NUM
admet-1474	153	100	697.67	697.67	NUM
admet-1474	153	101	1.19	1.19	NUM
admet-1474	153	102	15.69	15.69	NUM
admet-1474	153	103	28.61	28.61	NUM
admet-1474	153	104	f5	f5	NOUN
admet-1474	153	105	517.24	517.24	NUM
admet-1474	153	106	666.67	666.67	NUM
admet-1474	153	107	1.29	1.29	NUM
admet-1474	153	108	22.41	22.41	NUM
admet-1474	153	109	24.44	24.44	NUM
admet-1474	153	110	reference	reference	NOUN
admet-1474	153	111	ranges	range	VERB
admet-1474	153	112	for	for	ADP
admet-1474	153	113	hausner	hausner	NOUN
admet-1474	153	114	ratio	ratio	NOUN
admet-1474	153	115	,	,	PUNCT
admet-1474	153	116	carr	carr	PROPN
admet-1474	153	117	’s	’s	PART
admet-1474	153	118	index	index	NOUN
admet-1474	153	119	and	and	CCONJ
admet-1474	153	120	angle	angle	NOUN
admet-1474	153	121	of	of	ADP
admet-1474	153	122	repose	repose	NOUN
admet-1474	153	123	are	be	AUX
admet-1474	153	124	:	:	PUNCT
admet-1474	153	125	carr	carr	PROPN
admet-1474	153	126	’s	’s	PART
admet-1474	153	127	index	index	NOUN
admet-1474	153	128	<	<	X
admet-1474	153	129	32	32	NUM
admet-1474	153	130	%	%	NOUN
admet-1474	153	131	,	,	PUNCT
admet-1474	153	132	hausner	hausner	NOUN
admet-1474	153	133	ratio	ratio	NOUN
admet-1474	153	134	<	<	X
admet-1474	153	135	1.5	1.5	NUM
admet-1474	153	136	,	,	PUNCT
admet-1474	153	137	angle	angle	NOUN
admet-1474	153	138	of	of	ADP
admet-1474	153	139	repose	repose	NOUN
admet-1474	153	140	<	<	X
admet-1474	153	141	35	35	NUM
admet-1474	153	142	table	table	NOUN
admet-1474	154	1	3	3	NUM
admet-1474	154	2	.	.	PUNCT
admet-1474	154	3	validation	validation	NOUN
admet-1474	154	4	parameters	parameter	NOUN
admet-1474	154	5	of	of	ADP
admet-1474	154	6	the	the	DET
admet-1474	154	7	hplc	hplc	NOUN
admet-1474	154	8	method	method	NOUN
admet-1474	154	9	quantification	quantification	NOUN
admet-1474	154	10	of	of	ADP
admet-1474	154	11	levodopa	levodopa	NOUN
admet-1474	154	12	and	and	CCONJ
admet-1474	154	13	carbidopa	carbidopa	NOUN
admet-1474	154	14	validation	validation	NOUN
admet-1474	154	15	parameters	parameter	NOUN
admet-1474	154	16	results	result	VERB
admet-1474	154	17	levodopa	levodopa	NOUN
admet-1474	154	18	carbidopa	carbidopa	NOUN
admet-1474	154	19	retention	retention	NOUN
admet-1474	154	20	time	time	NOUN
admet-1474	155	1	[	[	X
admet-1474	155	2	mean	mean	X
admet-1474	155	3	±	±	NUM
admet-1474	155	4	s.d	s.d	PROPN
admet-1474	155	5	.	.	PUNCT
admet-1474	155	6	(	(	PUNCT
admet-1474	155	7	n=7	n=7	PROPN
admet-1474	155	8	)	)	PUNCT
admet-1474	155	9	]	]	PUNCT
admet-1474	156	1	3.70	3.70	NUM
admet-1474	156	2	±	±	NUM
admet-1474	156	3	0.186	0.186	NUM
admet-1474	156	4	5.50	5.50	NUM
admet-1474	156	5	±	±	NUM
admet-1474	156	6	0.0018	0.0018	NUM
admet-1474	156	7	linear	linear	ADJ
admet-1474	156	8	range	range	NOUN
admet-1474	156	9	(	(	PUNCT
admet-1474	156	10	μg	μg	NOUN
admet-1474	156	11	/	/	SYM
admet-1474	156	12	ml	ml	NOUN
admet-1474	156	13	)	)	PUNCT
admet-1474	156	14	0.00	0.00	NUM
admet-1474	156	15	–	–	PUNCT
admet-1474	156	16	25.00	25.00	NUM
admet-1474	156	17	0.00	0.00	NUM
admet-1474	156	18	–	–	PUNCT
admet-1474	156	19	12.50	12.50	NUM
admet-1474	156	20	correlation	correlation	NOUN
admet-1474	156	21	coefficient	coefficient	NOUN
admet-1474	156	22	(	(	PUNCT
admet-1474	156	23	r2	r2	PROPN
admet-1474	156	24	)	)	PUNCT
admet-1474	156	25	0.9997	0.9997	NUM
admet-1474	156	26	0.9994	0.9994	NUM
admet-1474	156	27	regression	regression	NOUN
admet-1474	156	28	equation	equation	NOUN
admet-1474	156	29	y	y	NOUN
admet-1474	156	30	=	=	PUNCT
admet-1474	156	31	29.469x	29.469x	PROPN
admet-1474	157	1	+	+	CCONJ
admet-1474	158	1	2.9818	2.9818	NUM
admet-1474	158	2	y	y	NOUN
admet-1474	158	3	=	=	SYM
admet-1474	158	4	12.794x	12.794x	NUM
admet-1474	158	5	+	+	CCONJ
admet-1474	158	6	1.2489	1.2489	NUM
admet-1474	158	7	precision	precision	NOUN
admet-1474	158	8	(	(	PUNCT
admet-1474	158	9	n=6	n=6	NOUN
admet-1474	158	10	%	%	NOUN
admet-1474	158	11	rsd	rsd	NOUN
admet-1474	158	12	)	)	PUNCT
admet-1474	158	13	0.6050	0.6050	NUM
admet-1474	158	14	1.875	1.875	NUM
admet-1474	158	15	loq	loq	PROPN
admet-1474	158	16	(	(	PUNCT
admet-1474	158	17	μg	μg	PROPN
admet-1474	158	18	/	/	SYM
admet-1474	158	19	ml	ml	NOUN
admet-1474	158	20	)	)	PUNCT
admet-1474	158	21	1.3405	1.3405	NUM
admet-1474	158	22	±	±	NOUN
admet-1474	158	23	0.056	0.056	NUM
admet-1474	158	24	1.1355	1.1355	NUM
admet-1474	158	25	±	±	NUM
admet-1474	158	26	0.04	0.04	NUM
admet-1474	158	27	lod	lod	PROPN
admet-1474	158	28	(	(	PUNCT
admet-1474	158	29	μg	μg	PROPN
admet-1474	158	30	/	/	SYM
admet-1474	158	31	ml	ml	NOUN
admet-1474	158	32	)	)	PUNCT
admet-1474	158	33	0.6319	0.6319	NUM
admet-1474	158	34	±	±	NUM
admet-1474	158	35	0.0119	0.0119	NUM
admet-1474	158	36	0.5353	0.5353	NUM
admet-1474	158	37	±	±	NUM
admet-1474	158	38	0.021	0.021	NUM
admet-1474	158	39	wavelength	wavelength	NOUN
admet-1474	158	40	λ	λ	PROPN
admet-1474	158	41	(	(	PUNCT
admet-1474	158	42	nm	nm	PROPN
admet-1474	158	43	)	)	PUNCT
admet-1474	158	44	280	280	NUM
admet-1474	158	45	280	280	NUM
admet-1474	158	46	robustness	robustness	NOUN
admet-1474	158	47	(	(	PUNCT
admet-1474	158	48	flowrate	flowrate	ADJ
admet-1474	158	49	:	:	PUNCT
admet-1474	158	50	0.5	0.5	NUM
admet-1474	158	51	ml	ml	NOUN
admet-1474	158	52	/	/	SYM
admet-1474	158	53	min	min	NOUN
admet-1474	158	54	)	)	PUNCT
admet-1474	158	55	99.044	99.044	NUM
admet-1474	158	56	±	±	NUM
admet-1474	158	57	0.085	0.085	NUM
admet-1474	158	58	98.140	98.140	NUM
admet-1474	158	59	±	±	NOUN
admet-1474	158	60	0.180	0.180	NUM
admet-1474	158	61	robustness	robustness	NOUN
admet-1474	158	62	(	(	PUNCT
admet-1474	158	63	flowrate	flowrate	ADJ
admet-1474	158	64	:	:	PUNCT
admet-1474	158	65	0.7	0.7	NUM
admet-1474	158	66	ml	ml	NOUN
admet-1474	158	67	/	/	SYM
admet-1474	158	68	min	min	NOUN
admet-1474	158	69	)	)	PUNCT
admet-1474	158	70	100.039	100.039	NUM
admet-1474	158	71	±	±	NUM
admet-1474	158	72	0.067	0.067	NUM
admet-1474	158	73	100.933	100.933	NUM
admet-1474	158	74	±	±	NUM
admet-1474	158	75	0.119	0.119	NUM
admet-1474	158	76	robustness	robustness	NOUN
admet-1474	158	77	(	(	PUNCT
admet-1474	158	78	temperature	temperature	NOUN
admet-1474	158	79	35	35	NUM
admet-1474	158	80	°	°	NOUN
admet-1474	158	81	c	c	NOUN
admet-1474	158	82	)	)	PUNCT
admet-1474	158	83	98.320	98.320	NUM
admet-1474	158	84	±	±	NUM
admet-1474	158	85	0.085	0.085	NUM
admet-1474	158	86	98.015	98.015	NUM
admet-1474	158	87	±	±	NOUN
admet-1474	158	88	0.078	0.078	NUM
admet-1474	158	89	robustness	robustness	NOUN
admet-1474	158	90	(	(	PUNCT
admet-1474	158	91	wavelength	wavelength	NOUN
admet-1474	158	92	282	282	NUM
admet-1474	158	93	nm	nm	NOUN
admet-1474	158	94	)	)	PUNCT
admet-1474	158	95	100.311	100.311	NUM
admet-1474	158	96	±	±	NUM
admet-1474	158	97	0.087	0.087	NUM
admet-1474	158	98	101.558	101.558	NUM
admet-1474	158	99	±	±	NUM
admet-1474	158	100	0.090	0.090	NUM
admet-1474	158	101	sd	sd	NOUN
admet-1474	158	102	:	:	PUNCT
admet-1474	158	103	standard	standard	ADJ
admet-1474	158	104	deviation	deviation	NOUN
admet-1474	158	105	,	,	PUNCT
admet-1474	158	106	rsd	rsd	NOUN
admet-1474	158	107	:	:	PUNCT
admet-1474	158	108	relative	relative	ADJ
admet-1474	158	109	standard	standard	ADJ
admet-1474	158	110	deviation	deviation	NOUN
admet-1474	158	111	,	,	PUNCT
admet-1474	158	112	loq	loq	PROPN
admet-1474	158	113	:	:	PUNCT
admet-1474	158	114	limit	limit	NOUN
admet-1474	158	115	of	of	ADP
admet-1474	158	116	quantification	quantification	NOUN
admet-1474	158	117	,	,	PUNCT
admet-1474	158	118	lod	lod	PROPN
admet-1474	158	119	:	:	PUNCT
admet-1474	158	120	limit	limit	NOUN
admet-1474	158	121	of	of	ADP
admet-1474	158	122	detection	detection	NOUN
admet-1474	158	123	admet	admet	NOUN
admet-1474	158	124	&	&	CCONJ
admet-1474	158	125	dmpk	dmpk	PROPN
admet-1474	158	126	11(1	11(1	NUM
admet-1474	158	127	)	)	PUNCT
admet-1474	158	128	(	(	PUNCT
admet-1474	158	129	2023	2023	NUM
admet-1474	158	130	)	)	PUNCT
admet-1474	158	131	97	97	NUM
admet-1474	158	132	-	-	SYM
admet-1474	158	133	115	115	NUM
admet-1474	158	134	evaluation	evaluation	NOUN
admet-1474	158	135	of	of	ADP
admet-1474	158	136	re	re	ADJ
admet-1474	158	137	-	-	ADJ
admet-1474	158	138	formulated	formulate	VERB
admet-1474	158	139	levodopa	levodopa	NOUN
admet-1474	158	140	and	and	CCONJ
admet-1474	158	141	carbidopa	carbidopa	NOUN
admet-1474	158	142	doi	doi	NOUN
admet-1474	158	143	:	:	PUNCT
admet-1474	158	144	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	158	145	105	105	NUM
admet-1474	158	146	drug	drug	NOUN
admet-1474	158	147	content	content	NOUN
admet-1474	158	148	and	and	CCONJ
admet-1474	158	149	loading	loading	NOUN
admet-1474	158	150	efficiency	efficiency	NOUN
admet-1474	158	151	the	the	DET
admet-1474	158	152	content	content	NOUN
admet-1474	158	153	(	(	PUNCT
admet-1474	158	154	%	%	INTJ
admet-1474	158	155	)	)	PUNCT
admet-1474	158	156	of	of	ADP
admet-1474	158	157	levodopa	levodopa	NOUN
admet-1474	158	158	and	and	CCONJ
admet-1474	158	159	carbidopa	carbidopa	NOUN
admet-1474	158	160	in	in	ADP
admet-1474	158	161	the	the	DET
admet-1474	158	162	various	various	ADJ
admet-1474	158	163	formulations	formulation	NOUN
admet-1474	158	164	is	be	AUX
admet-1474	158	165	shown	show	VERB
admet-1474	158	166	in	in	ADP
admet-1474	158	167	table	table	NOUN
admet-1474	158	168	4	4	NUM
admet-1474	158	169	.	.	PUNCT
admet-1474	159	1	the	the	DET
admet-1474	159	2	content	content	NOUN
admet-1474	159	3	of	of	ADP
admet-1474	159	4	levodopa	levodopa	NOUN
admet-1474	159	5	and	and	CCONJ
admet-1474	159	6	carbidopa	carbidopa	NOUN
admet-1474	159	7	in	in	ADP
admet-1474	159	8	formulation	formulation	NOUN
admet-1474	159	9	5	5	NUM
admet-1474	159	10	(	(	PUNCT
admet-1474	159	11	f5	f5	NOUN
admet-1474	159	12	)	)	PUNCT
admet-1474	159	13	was	be	AUX
admet-1474	159	14	above	above	ADP
admet-1474	159	15	the	the	DET
admet-1474	159	16	acceptable	acceptable	ADJ
admet-1474	159	17	criteria	criterion	NOUN
admet-1474	159	18	.	.	PUNCT
admet-1474	160	1	acceptance	acceptance	NOUN
admet-1474	160	2	criteria	criterion	NOUN
admet-1474	160	3	:	:	PUNCT
admet-1474	160	4	levodopa	levodopa	NOUN
admet-1474	160	5	/	/	SYM
admet-1474	160	6	carbidopa	carbidopa	NOUN
admet-1474	160	7	extended	extend	VERB
admet-1474	160	8	-	-	PUNCT
admet-1474	160	9	release	release	NOUN
admet-1474	160	10	formulations	formulation	NOUN
admet-1474	160	11	should	should	AUX
admet-1474	160	12	contain	contain	VERB
admet-1474	160	13	not	not	PART
admet-1474	160	14	less	less	ADJ
admet-1474	160	15	than	than	ADP
admet-1474	160	16	90.0	90.0	NUM
admet-1474	160	17	%	%	NOUN
admet-1474	160	18	and	and	CCONJ
admet-1474	160	19	not	not	PART
admet-1474	160	20	more	more	ADJ
admet-1474	160	21	than	than	ADP
admet-1474	160	22	110.0	110.0	NUM
admet-1474	160	23	%	%	NOUN
admet-1474	160	24	of	of	ADP
admet-1474	160	25	the	the	DET
admet-1474	160	26	stated	state	VERB
admet-1474	160	27	amount	amount	NOUN
admet-1474	160	28	of	of	ADP
admet-1474	160	29	levodopa	levodopa	NOUN
admet-1474	160	30	and	and	CCONJ
admet-1474	160	31	carbidopa	carbidopa	NOUN
admet-1474	160	32	.	.	PUNCT
admet-1474	161	1	additionally	additionally	ADV
admet-1474	161	2	,	,	PUNCT
admet-1474	161	3	the	the	DET
admet-1474	161	4	loading	loading	NOUN
admet-1474	161	5	efficiencies	efficiency	NOUN
admet-1474	161	6	of	of	ADP
admet-1474	161	7	the	the	DET
admet-1474	161	8	various	various	ADJ
admet-1474	161	9	formulations	formulation	NOUN
admet-1474	161	10	are	be	AUX
admet-1474	161	11	shown	show	VERB
admet-1474	161	12	in	in	ADP
admet-1474	161	13	table	table	NOUN
admet-1474	161	14	4	4	NUM
admet-1474	161	15	.	.	PUNCT
admet-1474	161	16	table	table	NOUN
admet-1474	161	17	4	4	NUM
admet-1474	161	18	.	.	PUNCT
admet-1474	161	19	drug	drug	NOUN
admet-1474	161	20	content	content	NOUN
admet-1474	161	21	and	and	CCONJ
admet-1474	161	22	loading	loading	NOUN
admet-1474	161	23	efficiency	efficiency	NOUN
admet-1474	161	24	of	of	ADP
admet-1474	161	25	formulations	formulation	NOUN
admet-1474	161	26	formulation	formulation	NOUN
admet-1474	161	27	average	average	ADJ
admet-1474	161	28	%	%	NOUN
admet-1474	161	29	content	content	NOUN
admet-1474	161	30	±	±	NUM
admet-1474	161	31	stdev	stdev	NOUN
admet-1474	161	32	loading	loading	NOUN
admet-1474	161	33	efficiency	efficiency	NOUN
admet-1474	161	34	(	(	PUNCT
admet-1474	161	35	%	%	INTJ
admet-1474	161	36	)	)	PUNCT
admet-1474	161	37	±	±	NOUN
admet-1474	161	38	stdev	stdev	NOUN
admet-1474	161	39	levodopa	levodopa	NOUN
admet-1474	161	40	carbidopa	carbidopa	NOUN
admet-1474	161	41	levodopa	levodopa	NOUN
admet-1474	161	42	carbidopa	carbidopa	NOUN
admet-1474	161	43	f1	f1	NOUN
admet-1474	161	44	107.20	107.20	NUM
admet-1474	161	45	±	±	NUM
admet-1474	161	46	10.56	10.56	NUM
admet-1474	161	47	104.73	104.73	NUM
admet-1474	161	48	±	±	NUM
admet-1474	161	49	3.67	3.67	NUM
admet-1474	161	50	75.43	75.43	NUM
admet-1474	161	51	±	±	NUM
admet-1474	161	52	6.52	6.52	NUM
admet-1474	161	53	63.43	63.43	NUM
admet-1474	161	54	±	±	NUM
admet-1474	161	55	4.22	4.22	NUM
admet-1474	161	56	f2	f2	PROPN
admet-1474	161	57	91.25	91.25	NUM
admet-1474	161	58	±	±	NUM
admet-1474	161	59	5.29	5.29	NUM
admet-1474	161	60	96.59	96.59	NUM
admet-1474	161	61	±	±	NUM
admet-1474	161	62	3.93	3.93	NUM
admet-1474	161	63	81.23	81.23	NUM
admet-1474	161	64	±	±	NUM
admet-1474	161	65	4.11	4.11	NUM
admet-1474	161	66	68.31	68.31	NUM
admet-1474	161	67	±	±	NUM
admet-1474	161	68	6.69	6.69	NUM
admet-1474	161	69	f3	f3	NOUN
admet-1474	161	70	100.70	100.70	NUM
admet-1474	161	71	±	±	NUM
admet-1474	161	72	0.12	0.12	NUM
admet-1474	161	73	99.03	99.03	NUM
admet-1474	161	74	±	±	NUM
admet-1474	161	75	2.57	2.57	NUM
admet-1474	161	76	93.86	93.86	NUM
admet-1474	161	77	±	±	NUM
admet-1474	161	78	3.26	3.26	NUM
admet-1474	161	79	85.23	85.23	NUM
admet-1474	161	80	±	±	NUM
admet-1474	161	81	4.57	4.57	NUM
admet-1474	161	82	f4	f4	PROPN
admet-1474	161	83	93.51	93.51	NUM
admet-1474	161	84	±	±	NUM
admet-1474	161	85	0.28	0.28	NUM
admet-1474	161	86	91.96	91.96	NUM
admet-1474	161	87	±	±	NUM
admet-1474	161	88	1.82	1.82	NUM
admet-1474	161	89	89.31	89.31	NUM
admet-1474	161	90	±	±	NUM
admet-1474	161	91	2.52	2.52	NUM
admet-1474	161	92	81.35	81.35	NUM
admet-1474	161	93	±	±	NUM
admet-1474	161	94	1.77	1.77	NUM
admet-1474	161	95	f5	f5	NOUN
admet-1474	161	96	114.68	114.68	NUM
admet-1474	161	97	±	±	NUM
admet-1474	161	98	5.26	5.26	NUM
admet-1474	161	99	114.73	114.73	NUM
admet-1474	161	100	±	±	NUM
admet-1474	161	101	1.62	1.62	NUM
admet-1474	161	102	65.43	65.43	NUM
admet-1474	161	103	±	±	NUM
admet-1474	161	104	6.68	6.68	NUM
admet-1474	161	105	55.91	55.91	NUM
admet-1474	161	106	±	±	NUM
admet-1474	161	107	8.63	8.63	NUM
admet-1474	161	108	in	in	ADP
admet-1474	161	109	vitro	vitro	X
admet-1474	161	110	drug	drug	NOUN
admet-1474	161	111	release	release	NOUN
admet-1474	161	112	over	over	ADP
admet-1474	161	113	a	a	DET
admet-1474	161	114	24	24	NUM
admet-1474	161	115	hr	hr	NOUN
admet-1474	161	116	period	period	NOUN
admet-1474	161	117	,	,	PUNCT
admet-1474	161	118	the	the	DET
admet-1474	161	119	release	release	NOUN
admet-1474	161	120	of	of	ADP
admet-1474	161	121	levodopa	levodopa	NOUN
admet-1474	161	122	and	and	CCONJ
admet-1474	161	123	carbidopa	carbidopa	NOUN
admet-1474	161	124	are	be	AUX
admet-1474	161	125	shown	show	VERB
admet-1474	161	126	in	in	ADP
admet-1474	161	127	figure	figure	NOUN
admet-1474	161	128	3	3	NUM
admet-1474	161	129	and	and	CCONJ
admet-1474	161	130	figure	figure	VERB
admet-1474	161	131	4	4	NUM
admet-1474	161	132	.	.	PUNCT
admet-1474	162	1	in	in	ADP
admet-1474	162	2	general	general	ADJ
admet-1474	162	3	,	,	PUNCT
admet-1474	162	4	levodopa	levodopa	NOUN
admet-1474	162	5	release	release	NOUN
admet-1474	162	6	was	be	AUX
admet-1474	162	7	found	find	VERB
admet-1474	162	8	to	to	PART
admet-1474	162	9	increase	increase	VERB
admet-1474	162	10	steadily	steadily	ADV
admet-1474	162	11	.	.	PUNCT
admet-1474	163	1	the	the	DET
admet-1474	163	2	release	release	NOUN
admet-1474	163	3	of	of	ADP
admet-1474	163	4	carbidopa	carbidopa	NOUN
admet-1474	163	5	,	,	PUNCT
admet-1474	163	6	however	however	ADV
admet-1474	163	7	,	,	PUNCT
admet-1474	163	8	declined	decline	VERB
admet-1474	163	9	sharply	sharply	ADV
admet-1474	163	10	in	in	ADP
admet-1474	163	11	phosphate	phosphate	ADJ
admet-1474	163	12	buffer	buffer	NOUN
admet-1474	163	13	(	(	PUNCT
admet-1474	163	14	ph	ph	NOUN
admet-1474	163	15	6.8	6.8	NUM
admet-1474	163	16	)	)	PUNCT
admet-1474	163	17	after	after	ADP
admet-1474	163	18	a	a	DET
admet-1474	163	19	4	4	NUM
admet-1474	163	20	hr	hr	NOUN
admet-1474	163	21	period	period	NOUN
admet-1474	163	22	for	for	ADP
admet-1474	163	23	all	all	DET
admet-1474	163	24	formulations	formulation	NOUN
admet-1474	163	25	.	.	PUNCT
admet-1474	164	1	concentration	concentration	NOUN
admet-1474	164	2	-	-	PUNCT
admet-1474	164	3	time	time	NOUN
admet-1474	164	4	curves	curve	NOUN
admet-1474	164	5	concentration	concentration	NOUN
admet-1474	164	6	-	-	PUNCT
admet-1474	164	7	time	time	NOUN
admet-1474	164	8	curves	curve	NOUN
admet-1474	164	9	of	of	ADP
admet-1474	164	10	levodopa	levodopa	NOUN
admet-1474	164	11	for	for	ADP
admet-1474	164	12	the	the	DET
admet-1474	164	13	treatment	treatment	NOUN
admet-1474	164	14	groups	group	NOUN
admet-1474	164	15	are	be	AUX
admet-1474	164	16	shown	show	VERB
admet-1474	164	17	in	in	ADP
admet-1474	164	18	figure	figure	NOUN
admet-1474	164	19	5	5	NUM
admet-1474	164	20	(	(	PUNCT
admet-1474	164	21	a	a	PRON
admet-1474	164	22	and	and	CCONJ
admet-1474	164	23	b	b	NOUN
admet-1474	164	24	)	)	PUNCT
admet-1474	164	25	.	.	PUNCT
admet-1474	165	1	peak	peak	NOUN
admet-1474	165	2	concentration	concentration	NOUN
admet-1474	165	3	(	(	PUNCT
admet-1474	165	4	cmax	cmax	NOUN
admet-1474	165	5	)	)	PUNCT
admet-1474	165	6	and	and	CCONJ
admet-1474	165	7	time	time	NOUN
admet-1474	165	8	to	to	PART
admet-1474	165	9	reach	reach	VERB
admet-1474	165	10	the	the	DET
admet-1474	165	11	peak	peak	NOUN
admet-1474	165	12	(	(	PUNCT
admet-1474	165	13	tmax	tmax	ADV
admet-1474	165	14	)	)	PUNCT
admet-1474	165	15	were	be	AUX
admet-1474	165	16	higher	high	ADJ
admet-1474	165	17	for	for	SCONJ
admet-1474	165	18	the	the	DET
admet-1474	165	19	groups	group	NOUN
admet-1474	165	20	administered	administer	VERB
admet-1474	165	21	a	a	DET
admet-1474	165	22	chitosanpectin	chitosanpectin	NOUN
admet-1474	165	23	-	-	PUNCT
admet-1474	165	24	based	base	VERB
admet-1474	165	25	matrix	matrix	NOUN
admet-1474	165	26	of	of	ADP
admet-1474	165	27	levodopa	levodopa	NOUN
admet-1474	165	28	/	/	SYM
admet-1474	165	29	carbidopa	carbidopa	NOUN
admet-1474	165	30	.	.	PUNCT
admet-1474	166	1	rats	rat	NOUN
admet-1474	166	2	administered	administer	VERB
admet-1474	166	3	pure	pure	ADJ
admet-1474	166	4	levodopa	levodopa	NOUN
admet-1474	166	5	/	/	SYM
admet-1474	166	6	carbidopa	carbidopa	NOUN
admet-1474	166	7	had	have	VERB
admet-1474	166	8	the	the	DET
admet-1474	166	9	lowest	low	ADJ
admet-1474	166	10	cmax	cmax	NOUN
admet-1474	166	11	.	.	PUNCT
admet-1474	167	1	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	167	2	parameters	parameter	NOUN
admet-1474	167	3	the	the	DET
admet-1474	167	4	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	167	5	parameters	parameter	NOUN
admet-1474	167	6	of	of	ADP
admet-1474	167	7	levodopa	levodopa	NOUN
admet-1474	167	8	derived	derive	VERB
admet-1474	167	9	from	from	ADP
admet-1474	167	10	concentration	concentration	NOUN
admet-1474	167	11	-	-	PUNCT
admet-1474	167	12	time	time	NOUN
admet-1474	167	13	and	and	CCONJ
admet-1474	167	14	log	log	VERB
admet-1474	167	15	concentrationtime	concentrationtime	ADJ
admet-1474	167	16	plots	plot	NOUN
admet-1474	167	17	are	be	AUX
admet-1474	167	18	shown	show	VERB
admet-1474	167	19	in	in	ADP
admet-1474	167	20	table	table	NOUN
admet-1474	167	21	4	4	NUM
admet-1474	167	22	.	.	PUNCT
admet-1474	167	23	one	one	NUM
admet-1474	167	24	-	-	PUNCT
admet-1474	167	25	way	way	NOUN
admet-1474	167	26	anova	anova	PROPN
admet-1474	167	27	performed	perform	VERB
admet-1474	167	28	on	on	ADP
admet-1474	167	29	tmax	tmax	PROPN
admet-1474	167	30	,	,	PUNCT
admet-1474	167	31	cmax	cmax	NOUN
admet-1474	167	32	,	,	PUNCT
admet-1474	167	33	area	area	NOUN
admet-1474	167	34	under	under	ADP
admet-1474	167	35	the	the	DET
admet-1474	167	36	concentrationtime	concentrationtime	ADJ
admet-1474	167	37	curve	curve	NOUN
admet-1474	167	38	(	(	PUNCT
admet-1474	167	39	auc	auc	NOUN
admet-1474	167	40	)	)	PUNCT
admet-1474	167	41	,	,	PUNCT
admet-1474	167	42	elimination	elimination	NOUN
admet-1474	167	43	rate	rate	NOUN
admet-1474	167	44	constant	constant	ADJ
admet-1474	167	45	(	(	PUNCT
admet-1474	167	46	ke	ke	NOUN
admet-1474	167	47	)	)	PUNCT
admet-1474	167	48	and	and	CCONJ
admet-1474	167	49	half	half	ADJ
admet-1474	167	50	-	-	PUNCT
admet-1474	167	51	life	life	NOUN
admet-1474	167	52	(	(	PUNCT
admet-1474	167	53	t1/2	t1/2	NOUN
admet-1474	167	54	)	)	PUNCT
admet-1474	167	55	varied	varied	ADJ
admet-1474	167	56	significantly	significantly	ADV
admet-1474	167	57	(	(	PUNCT
admet-1474	167	58	p	p	X
admet-1474	167	59	<	<	X
admet-1474	167	60	0.05	0.05	NUM
admet-1474	167	61	)	)	PUNCT
admet-1474	167	62	between	between	ADP
admet-1474	167	63	the	the	DET
admet-1474	167	64	four	four	NUM
admet-1474	167	65	treatment	treatment	NOUN
admet-1474	167	66	groups	group	NOUN
admet-1474	167	67	.	.	PUNCT
admet-1474	168	1	cmax	cmax	NOUN
admet-1474	168	2	of	of	ADP
admet-1474	168	3	levodopa	levodopa	NOUN
admet-1474	168	4	was	be	AUX
admet-1474	168	5	found	find	VERB
admet-1474	168	6	to	to	PART
admet-1474	168	7	be	be	AUX
admet-1474	168	8	higher	high	ADJ
admet-1474	168	9	for	for	ADP
admet-1474	168	10	formulations	formulation	NOUN
admet-1474	168	11	f3	f3	ADJ
admet-1474	168	12	and	and	CCONJ
admet-1474	168	13	f4	f4	PROPN
admet-1474	168	14	.	.	PUNCT
admet-1474	169	1	auc0	auc0	PROPN
admet-1474	169	2	-	-	PUNCT
admet-1474	169	3	24	24	NUM
admet-1474	169	4	and	and	CCONJ
admet-1474	169	5	auc0-∞	auc0-∞	NUM
admet-1474	169	6	of	of	ADP
admet-1474	169	7	levodopa	levodopa	NOUN
admet-1474	169	8	for	for	ADP
admet-1474	169	9	formulations	formulation	NOUN
admet-1474	169	10	f3	f3	ADJ
admet-1474	169	11	and	and	CCONJ
admet-1474	169	12	f4	f4	PROPN
admet-1474	169	13	were	be	AUX
admet-1474	169	14	found	find	VERB
admet-1474	169	15	to	to	PART
admet-1474	169	16	be	be	AUX
admet-1474	169	17	2	2	NUM
admet-1474	169	18	-	-	NOUN
admet-1474	169	19	fold	fold	VERB
admet-1474	169	20	greater	great	ADJ
admet-1474	169	21	than	than	ADP
admet-1474	169	22	the	the	DET
admet-1474	169	23	other	other	ADJ
admet-1474	169	24	formulations	formulation	NOUN
admet-1474	169	25	.	.	PUNCT
admet-1474	170	1	additionally	additionally	ADV
admet-1474	170	2	,	,	PUNCT
admet-1474	170	3	the	the	DET
admet-1474	170	4	t1/2	t1/2	NOUN
admet-1474	170	5	for	for	ADP
admet-1474	170	6	formulations	formulation	NOUN
admet-1474	170	7	f3	f3	ADJ
admet-1474	170	8	and	and	CCONJ
admet-1474	170	9	f4	f4	PROPN
admet-1474	170	10	were	be	AUX
admet-1474	170	11	relatively	relatively	ADV
admet-1474	170	12	longer	long	ADV
admet-1474	170	13	compared	compare	VERB
admet-1474	170	14	to	to	ADP
admet-1474	170	15	sinemet	sinemet	PROPN
admet-1474	170	16	®	®	PROPN
admet-1474	170	17	cr	cr	PROPN
admet-1474	170	18	.	.	PUNCT
admet-1474	171	1	a	a	DET
admet-1474	171	2	comparison	comparison	NOUN
admet-1474	171	3	of	of	ADP
admet-1474	171	4	the	the	DET
admet-1474	171	5	auc0-∞	auc0-∞	PROPN
admet-1474	171	6	and	and	CCONJ
admet-1474	171	7	auc0	auc0	PROPN
admet-1474	171	8	-	-	PUNCT
admet-1474	171	9	24hr	24hr	NOUN
admet-1474	171	10	between	between	ADP
admet-1474	171	11	f3	f3	PROPN
admet-1474	171	12	and	and	CCONJ
admet-1474	171	13	sinemet	sinemet	PROPN
admet-1474	171	14	®	®	PROPN
admet-1474	171	15	cr	cr	PROPN
admet-1474	171	16	and	and	CCONJ
admet-1474	171	17	between	between	ADP
admet-1474	171	18	f4	f4	ADJ
admet-1474	171	19	and	and	CCONJ
admet-1474	171	20	sinemet	sinemet	PROPN
admet-1474	171	21	®	®	NOUN
admet-1474	171	22	cr	cr	NOUN
admet-1474	171	23	were	be	AUX
admet-1474	171	24	all	all	PRON
admet-1474	171	25	found	find	VERB
admet-1474	171	26	to	to	PART
admet-1474	171	27	differ	differ	VERB
admet-1474	171	28	significantly	significantly	ADV
admet-1474	171	29	(	(	PUNCT
admet-1474	171	30	p	p	X
admet-1474	171	31	<	<	X
admet-1474	171	32	0.0001	0.0001	NUM
admet-1474	171	33	)	)	PUNCT
admet-1474	171	34	.	.	PUNCT
admet-1474	172	1	a	a	DET
admet-1474	172	2	comparison	comparison	NOUN
admet-1474	172	3	between	between	ADP
admet-1474	172	4	the	the	DET
admet-1474	172	5	t1/2	t1/2	NOUN
admet-1474	172	6	of	of	ADP
admet-1474	172	7	f3	f3	ADJ
admet-1474	172	8	and	and	CCONJ
admet-1474	172	9	sinemet	sinemet	PROPN
admet-1474	172	10	®	®	NOUN
admet-1474	172	11	cr	cr	PROPN
admet-1474	172	12	showed	show	VERB
admet-1474	172	13	that	that	SCONJ
admet-1474	172	14	the	the	DET
admet-1474	172	15	difference	difference	NOUN
admet-1474	172	16	observed	observe	VERB
admet-1474	172	17	was	be	AUX
admet-1474	172	18	statistically	statistically	ADV
admet-1474	172	19	significant	significant	ADJ
admet-1474	172	20	(	(	PUNCT
admet-1474	172	21	p	p	X
admet-1474	172	22	<	<	X
admet-1474	172	23	0.0001	0.0001	NUM
admet-1474	172	24	)	)	PUNCT
admet-1474	172	25	.	.	PUNCT
admet-1474	173	1	the	the	DET
admet-1474	173	2	difference	difference	NOUN
admet-1474	173	3	between	between	ADP
admet-1474	173	4	the	the	DET
admet-1474	173	5	t1/2	t1/2	NOUN
admet-1474	173	6	of	of	ADP
admet-1474	173	7	sinemet	sinemet	PROPN
admet-1474	173	8	®	®	NOUN
admet-1474	173	9	cr	cr	PROPN
admet-1474	173	10	and	and	CCONJ
admet-1474	173	11	f4	f4	PROPN
admet-1474	173	12	was	be	AUX
admet-1474	173	13	also	also	ADV
admet-1474	173	14	found	find	VERB
admet-1474	173	15	to	to	PART
admet-1474	173	16	be	be	AUX
admet-1474	173	17	significant	significant	ADJ
admet-1474	173	18	(	(	PUNCT
admet-1474	173	19	p	p	X
admet-1474	173	20	<	<	X
admet-1474	173	21	0.0001	0.0001	NUM
admet-1474	173	22	)	)	PUNCT
admet-1474	173	23	.	.	PUNCT
admet-1474	174	1	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	174	2	emelia	emelia	PROPN
admet-1474	174	3	priscilla	priscilla	PROPN
admet-1474	174	4	imbeah	imbeah	PROPN
admet-1474	174	5	et	et	PROPN
admet-1474	174	6	al	al	PROPN
admet-1474	174	7	.	.	PROPN
admet-1474	174	8	admet	admet	PROPN
admet-1474	174	9	&	&	CCONJ
admet-1474	174	10	dmpk	dmpk	PROPN
admet-1474	174	11	11(1	11(1	NUM
admet-1474	174	12	)	)	PUNCT
admet-1474	174	13	(	(	PUNCT
admet-1474	174	14	2023	2023	NUM
admet-1474	174	15	)	)	PUNCT
admet-1474	174	16	97	97	NUM
admet-1474	174	17	-	-	SYM
admet-1474	174	18	115	115	NUM
admet-1474	174	19	106	106	NUM
admet-1474	174	20	figure	figure	NOUN
admet-1474	174	21	3	3	NUM
admet-1474	174	22	.	.	PUNCT
admet-1474	175	1	in	in	ADP
admet-1474	175	2	vitro	vitro	X
admet-1474	175	3	release	release	NOUN
admet-1474	175	4	of	of	ADP
admet-1474	175	5	levodopa	levodopa	NOUN
admet-1474	175	6	(	(	PUNCT
admet-1474	175	7	a	a	NOUN
admet-1474	175	8	)	)	PUNCT
admet-1474	175	9	and	and	CCONJ
admet-1474	175	10	carbidopa	carbidopa	ADV
admet-1474	175	11	(	(	PUNCT
admet-1474	175	12	b	b	NOUN
admet-1474	175	13	)	)	PUNCT
admet-1474	175	14	from	from	ADP
admet-1474	175	15	the	the	DET
admet-1474	175	16	various	various	ADJ
admet-1474	175	17	formulated	formulate	VERB
admet-1474	175	18	multiparticulate	multiparticulate	ADJ
admet-1474	175	19	matrices	matrix	NOUN
admet-1474	175	20	in	in	ADP
admet-1474	175	21	phosphate	phosphate	ADJ
admet-1474	175	22	buffered	buffer	VERB
admet-1474	175	23	saline	saline	NOUN
admet-1474	175	24	(	(	PUNCT
admet-1474	175	25	ph	ph	NOUN
admet-1474	175	26	=	=	NOUN
admet-1474	175	27	6.8	6.8	NUM
admet-1474	175	28	)	)	PUNCT
admet-1474	175	29	at	at	ADP
admet-1474	175	30	37	37	NUM
admet-1474	175	31	°	°	NOUN
admet-1474	175	32	c	c	NOUN
admet-1474	175	33	(	(	PUNCT
admet-1474	175	34	n=3	n=3	NOUN
admet-1474	175	35	)	)	PUNCT
admet-1474	175	36	.	.	PUNCT
admet-1474	176	1	error	error	NOUN
admet-1474	176	2	bars	bar	NOUN
admet-1474	176	3	indicate	indicate	VERB
admet-1474	176	4	sd	sd	NOUN
admet-1474	176	5	.	.	PUNCT
admet-1474	177	1	cocoa	cocoa	PROPN
admet-1474	177	2	pod	pod	PROPN
admet-1474	177	3	husk	husk	PROPN
admet-1474	177	4	(	(	PUNCT
admet-1474	177	5	cph	cph	NOUN
admet-1474	177	6	)	)	PUNCT
admet-1474	177	7	is	be	AUX
admet-1474	177	8	an	an	DET
admet-1474	177	9	environmentally	environmentally	ADV
admet-1474	177	10	and	and	CCONJ
admet-1474	177	11	economically	economically	ADV
admet-1474	177	12	friendly	friendly	ADJ
admet-1474	177	13	means	mean	NOUN
admet-1474	177	14	of	of	ADP
admet-1474	177	15	managing	manage	VERB
admet-1474	177	16	cph	cph	PROPN
admet-1474	177	17	waste	waste	NOUN
admet-1474	177	18	after	after	ADP
admet-1474	177	19	harvesting	harvest	VERB
admet-1474	177	20	the	the	DET
admet-1474	177	21	beans	bean	NOUN
admet-1474	177	22	from	from	ADP
admet-1474	177	23	the	the	DET
admet-1474	177	24	pods	pod	NOUN
admet-1474	177	25	.	.	PUNCT
admet-1474	178	1	in	in	ADP
admet-1474	178	2	the	the	DET
admet-1474	178	3	current	current	ADJ
admet-1474	178	4	study	study	NOUN
admet-1474	178	5	,	,	PUNCT
admet-1474	178	6	the	the	DET
admet-1474	178	7	yield	yield	NOUN
admet-1474	178	8	of	of	ADP
admet-1474	178	9	hot	hot	ADJ
admet-1474	178	10	water	water	NOUN
admet-1474	178	11	-	-	PUNCT
admet-1474	178	12	soluble	soluble	ADJ
admet-1474	178	13	pectin	pectin	NOUN
admet-1474	178	14	from	from	ADP
admet-1474	178	15	cph	cph	PROPN
admet-1474	178	16	was	be	AUX
admet-1474	178	17	7.91	7.91	NUM
admet-1474	178	18	%	%	NOUN
admet-1474	178	19	.	.	PUNCT
admet-1474	179	1	previous	previous	ADJ
admet-1474	179	2	studies	study	NOUN
admet-1474	179	3	have	have	AUX
admet-1474	179	4	reported	report	VERB
admet-1474	179	5	extraction	extraction	NOUN
admet-1474	179	6	yields	yield	NOUN
admet-1474	179	7	of	of	ADP
admet-1474	179	8	23.3	23.3	NUM
admet-1474	179	9	%	%	NOUN
admet-1474	179	10	and	and	CCONJ
admet-1474	179	11	6.5	6.5	NUM
admet-1474	179	12	%	%	NOUN
admet-1474	179	13	for	for	ADP
admet-1474	179	14	hot	hot	ADJ
admet-1474	179	15	water	water	NOUN
admet-1474	179	16	-	-	PUNCT
admet-1474	179	17	soluble	soluble	ADJ
admet-1474	179	18	pectin	pectin	NOUN
admet-1474	179	19	[	[	X
admet-1474	179	20	13,24,25	13,24,25	NUM
admet-1474	179	21	]	]	PUNCT
admet-1474	179	22	.	.	PUNCT
admet-1474	180	1	the	the	DET
admet-1474	180	2	extraction	extraction	NOUN
admet-1474	180	3	yields	yield	NOUN
admet-1474	180	4	of	of	ADP
admet-1474	180	5	cph	cph	PROPN
admet-1474	180	6	pectin	pectin	NOUN
admet-1474	180	7	with	with	ADP
admet-1474	180	8	hot	hot	ADJ
admet-1474	180	9	water	water	NOUN
admet-1474	180	10	(	(	PUNCT
admet-1474	180	11	ph	ph	NOUN
admet-1474	180	12	7.0	7.0	NUM
admet-1474	180	13	)	)	PUNCT
admet-1474	180	14	have	have	AUX
admet-1474	180	15	been	be	AUX
admet-1474	180	16	shown	show	VERB
admet-1474	180	17	to	to	PART
admet-1474	180	18	depend	depend	VERB
admet-1474	180	19	largely	largely	ADV
admet-1474	180	20	on	on	ADP
admet-1474	180	21	factors	factor	NOUN
admet-1474	180	22	such	such	ADJ
admet-1474	180	23	as	as	ADP
admet-1474	180	24	the	the	DET
admet-1474	180	25	origin	origin	NOUN
admet-1474	180	26	of	of	ADP
admet-1474	180	27	cocoa	cocoa	NOUN
admet-1474	180	28	pods	pod	NOUN
admet-1474	180	29	,	,	PUNCT
admet-1474	180	30	extraction	extraction	NOUN
admet-1474	180	31	time	time	NOUN
admet-1474	180	32	,	,	PUNCT
admet-1474	180	33	as	as	ADV
admet-1474	180	34	well	well	ADV
admet-1474	180	35	as	as	ADP
admet-1474	180	36	the	the	DET
admet-1474	180	37	pre	pre	ADJ
admet-1474	180	38	-	-	ADJ
admet-1474	180	39	treatment	treatment	ADJ
admet-1474	180	40	methods	method	NOUN
admet-1474	180	41	employed	employ	VERB
admet-1474	180	42	[	[	X
admet-1474	180	43	25,26	25,26	NUM
admet-1474	180	44	]	]	PUNCT
admet-1474	180	45	.	.	PUNCT
admet-1474	181	1	admet	admet	PROPN
admet-1474	181	2	&	&	CCONJ
admet-1474	181	3	dmpk	dmpk	PROPN
admet-1474	181	4	11(1	11(1	NUM
admet-1474	181	5	)	)	PUNCT
admet-1474	181	6	(	(	PUNCT
admet-1474	181	7	2023	2023	NUM
admet-1474	181	8	)	)	PUNCT
admet-1474	181	9	97	97	NUM
admet-1474	181	10	-	-	SYM
admet-1474	181	11	115	115	NUM
admet-1474	181	12	evaluation	evaluation	NOUN
admet-1474	181	13	of	of	ADP
admet-1474	181	14	re	re	ADJ
admet-1474	181	15	-	-	ADJ
admet-1474	181	16	formulated	formulate	VERB
admet-1474	181	17	levodopa	levodopa	NOUN
admet-1474	181	18	and	and	CCONJ
admet-1474	181	19	carbidopa	carbidopa	NOUN
admet-1474	181	20	doi	doi	NOUN
admet-1474	181	21	:	:	PUNCT
admet-1474	181	22	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	181	23	107	107	NUM
admet-1474	181	24	figure	figure	NOUN
admet-1474	181	25	4	4	NUM
admet-1474	181	26	.	.	PUNCT
admet-1474	182	1	in	in	ADP
admet-1474	182	2	vitro	vitro	X
admet-1474	182	3	release	release	NOUN
admet-1474	182	4	of	of	ADP
admet-1474	182	5	levodopa	levodopa	NOUN
admet-1474	182	6	(	(	PUNCT
admet-1474	182	7	a	a	NOUN
admet-1474	182	8	)	)	PUNCT
admet-1474	182	9	and	and	CCONJ
admet-1474	182	10	carbidopa	carbidopa	ADV
admet-1474	182	11	(	(	PUNCT
admet-1474	182	12	b	b	NOUN
admet-1474	182	13	)	)	PUNCT
admet-1474	182	14	from	from	ADP
admet-1474	182	15	the	the	DET
admet-1474	182	16	optimized	optimize	VERB
admet-1474	182	17	formulations	formulation	NOUN
admet-1474	182	18	f3	f3	ADJ
admet-1474	182	19	and	and	CCONJ
admet-1474	182	20	f4	f4	NOUN
admet-1474	182	21	in	in	ADP
admet-1474	182	22	phosphate	phosphate	ADJ
admet-1474	182	23	buffered	buffer	VERB
admet-1474	182	24	saline	saline	NOUN
admet-1474	182	25	(	(	PUNCT
admet-1474	182	26	ph	ph	NOUN
admet-1474	182	27	=	=	NOUN
admet-1474	182	28	4.5	4.5	NUM
admet-1474	182	29	)	)	PUNCT
admet-1474	182	30	at	at	ADP
admet-1474	182	31	37	37	NUM
admet-1474	182	32	°	°	NOUN
admet-1474	182	33	c	c	NOUN
admet-1474	182	34	(	(	PUNCT
admet-1474	182	35	n=3	n=3	NOUN
admet-1474	182	36	)	)	PUNCT
admet-1474	182	37	.	.	PUNCT
admet-1474	183	1	error	error	NOUN
admet-1474	183	2	bars	bar	NOUN
admet-1474	183	3	indicate	indicate	VERB
admet-1474	183	4	sd	sd	NOUN
admet-1474	183	5	.	.	PUNCT
admet-1474	184	1	data	datum	NOUN
admet-1474	184	2	obtained	obtain	VERB
admet-1474	184	3	from	from	ADP
admet-1474	184	4	ftir	ftir	PROPN
admet-1474	184	5	spectroscopy	spectroscopy	NOUN
admet-1474	184	6	of	of	ADP
admet-1474	184	7	cph	cph	PROPN
admet-1474	184	8	pectin	pectin	NOUN
admet-1474	184	9	showed	show	VERB
admet-1474	184	10	a	a	DET
admet-1474	184	11	broad	broad	ADJ
admet-1474	184	12	absorption	absorption	NOUN
admet-1474	184	13	band	band	NOUN
admet-1474	184	14	at	at	ADP
admet-1474	184	15	3280	3280	NUM
admet-1474	184	16	cm-1	cm-1	NOUN
admet-1474	184	17	,	,	PUNCT
admet-1474	184	18	which	which	PRON
admet-1474	184	19	corresponds	correspond	VERB
admet-1474	184	20	to	to	ADP
admet-1474	184	21	hydroxyl	hydroxyl	NOUN
admet-1474	184	22	(	(	PUNCT
admet-1474	184	23	-oh	-oh	NOUN
admet-1474	184	24	)	)	PUNCT
admet-1474	184	25	stretching	stretching	NOUN
admet-1474	184	26	.	.	PUNCT
admet-1474	185	1	a	a	DET
admet-1474	185	2	band	band	NOUN
admet-1474	185	3	at	at	ADP
admet-1474	185	4	2932	2932	NUM
admet-1474	185	5	cm-1	cm-1	NOUN
admet-1474	185	6	corresponds	correspond	NOUN
admet-1474	185	7	to	to	ADP
admet-1474	185	8	tension	tension	NOUN
admet-1474	185	9	in	in	ADP
admet-1474	185	10	c	c	NOUN
admet-1474	185	11	-	-	NOUN
admet-1474	185	12	h	h	NOUN
admet-1474	185	13	due	due	ADP
admet-1474	185	14	to	to	ADP
admet-1474	185	15	the	the	DET
admet-1474	185	16	vibration	vibration	NOUN
admet-1474	185	17	of	of	ADP
admet-1474	185	18	methyl	methyl	NOUN
admet-1474	185	19	ester	ester	NOUN
admet-1474	185	20	groups	group	NOUN
admet-1474	185	21	.	.	PUNCT
admet-1474	186	1	the	the	DET
admet-1474	186	2	sharp	sharp	ADJ
admet-1474	186	3	absorption	absorption	NOUN
admet-1474	186	4	bands	band	NOUN
admet-1474	186	5	at	at	ADP
admet-1474	186	6	1735	1735	NUM
admet-1474	186	7	cm−1	cm−1	NOUN
admet-1474	186	8	and	and	CCONJ
admet-1474	186	9	1596	1596	NUM
admet-1474	186	10	cm-1	cm-1	NOUN
admet-1474	186	11	show	show	NOUN
admet-1474	186	12	esterified	esterify	VERB
admet-1474	186	13	and	and	CCONJ
admet-1474	186	14	non	non	ADJ
admet-1474	186	15	-	-	ADJ
admet-1474	186	16	esterified	esterify	VERB
admet-1474	186	17	carboxyl	carboxyl	NOUN
admet-1474	186	18	groups	group	NOUN
admet-1474	186	19	in	in	ADP
admet-1474	186	20	the	the	DET
admet-1474	186	21	cph	cph	PROPN
admet-1474	186	22	pectin	pectin	NOUN
admet-1474	186	23	.	.	PUNCT
admet-1474	187	1	absorption	absorption	NOUN
admet-1474	187	2	signals	signal	NOUN
admet-1474	187	3	between	between	ADP
admet-1474	187	4	1623	1623	NUM
admet-1474	187	5	and	and	CCONJ
admet-1474	187	6	1428	1428	NUM
admet-1474	187	7	cm−1	cm−1	NOUN
admet-1474	187	8	usually	usually	ADV
admet-1474	187	9	correspond	correspond	VERB
admet-1474	187	10	to	to	PART
admet-1474	187	11	wavelength	wavelength	VERB
admet-1474	187	12	features	feature	NOUN
admet-1474	187	13	of	of	ADP
admet-1474	187	14	polygalacturonic	polygalacturonic	ADJ
admet-1474	187	15	acid	acid	NOUN
admet-1474	187	16	[	[	X
admet-1474	187	17	27,28	27,28	NUM
admet-1474	187	18	]	]	X
admet-1474	187	19	.	.	PUNCT
admet-1474	188	1	thus	thus	ADV
admet-1474	188	2	,	,	PUNCT
admet-1474	188	3	the	the	DET
admet-1474	188	4	pectin	pectin	NOUN
admet-1474	188	5	extracted	extract	VERB
admet-1474	188	6	from	from	ADP
admet-1474	188	7	cph	cph	PROPN
admet-1474	188	8	can	can	AUX
admet-1474	188	9	be	be	AUX
admet-1474	188	10	said	say	VERB
admet-1474	188	11	to	to	PART
admet-1474	188	12	be	be	AUX
admet-1474	188	13	rich	rich	ADJ
admet-1474	188	14	in	in	ADP
admet-1474	188	15	polygalacturonic	polygalacturonic	ADJ
admet-1474	188	16	acid	acid	NOUN
admet-1474	188	17	[	[	X
admet-1474	188	18	29	29	NUM
admet-1474	188	19	]	]	PUNCT
admet-1474	188	20	.	.	PUNCT
admet-1474	189	1	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	189	2	emelia	emelia	PROPN
admet-1474	189	3	priscilla	priscilla	PROPN
admet-1474	189	4	imbeah	imbeah	PROPN
admet-1474	189	5	et	et	PROPN
admet-1474	189	6	al	al	PROPN
admet-1474	189	7	.	.	PROPN
admet-1474	189	8	admet	admet	PROPN
admet-1474	189	9	&	&	CCONJ
admet-1474	189	10	dmpk	dmpk	PROPN
admet-1474	189	11	11(1	11(1	NUM
admet-1474	189	12	)	)	PUNCT
admet-1474	189	13	(	(	PUNCT
admet-1474	189	14	2023	2023	NUM
admet-1474	189	15	)	)	PUNCT
admet-1474	189	16	97	97	NUM
admet-1474	189	17	-	-	SYM
admet-1474	189	18	115	115	NUM
admet-1474	189	19	108	108	NUM
admet-1474	189	20	figure	figure	NOUN
admet-1474	189	21	5	5	NUM
admet-1474	189	22	.	.	PUNCT
admet-1474	189	23	plasma	plasma	NOUN
admet-1474	189	24	concentration	concentration	NOUN
admet-1474	189	25	-	-	PUNCT
admet-1474	189	26	time	time	NOUN
admet-1474	189	27	(	(	PUNCT
admet-1474	189	28	a	a	NOUN
admet-1474	189	29	)	)	PUNCT
admet-1474	189	30	and	and	CCONJ
admet-1474	189	31	log	log	VERB
admet-1474	189	32	concentration	concentration	NOUN
admet-1474	189	33	-	-	PUNCT
admet-1474	189	34	time	time	NOUN
admet-1474	189	35	(	(	PUNCT
admet-1474	189	36	b	b	NOUN
admet-1474	189	37	)	)	PUNCT
admet-1474	189	38	curves	curve	NOUN
admet-1474	189	39	of	of	ADP
admet-1474	189	40	levodopa	levodopa	NOUN
admet-1474	189	41	for	for	ADP
admet-1474	189	42	the	the	DET
admet-1474	189	43	4	4	NUM
admet-1474	189	44	treatment	treatment	NOUN
admet-1474	189	45	groups	group	NOUN
admet-1474	189	46	(	(	PUNCT
admet-1474	189	47	n	n	NOUN
admet-1474	189	48	=	=	SYM
admet-1474	189	49	5	5	NUM
admet-1474	189	50	)	)	PUNCT
admet-1474	189	51	following	follow	VERB
admet-1474	189	52	administration	administration	NOUN
admet-1474	189	53	of	of	ADP
admet-1474	189	54	respective	respective	ADJ
admet-1474	189	55	formulations	formulation	NOUN
admet-1474	189	56	administered	administer	VERB
admet-1474	189	57	at	at	ADP
admet-1474	189	58	20/5	20/5	NUM
admet-1474	189	59	mg	mg	PROPN
admet-1474	189	60	/	/	SYM
admet-1474	189	61	kg	kg	PROPN
admet-1474	189	62	.	.	PUNCT
admet-1474	190	1	sinemet	sinemet	PROPN
admet-1474	190	2	®	®	PROPN
admet-1474	190	3	cr	cr	NOUN
admet-1474	190	4	=	=	PUNCT
admet-1474	190	5	a	a	DET
admet-1474	190	6	controlled	control	VERB
admet-1474	190	7	release	release	NOUN
admet-1474	190	8	formulation	formulation	NOUN
admet-1474	190	9	of	of	ADP
admet-1474	190	10	levodopa	levodopa	NOUN
admet-1474	190	11	/	/	SYM
admet-1474	190	12	carbidopa	carbidopa	NOUN
admet-1474	190	13	.	.	PUNCT
admet-1474	191	1	f3	f3	PROPN
admet-1474	191	2	=	=	SYM
admet-1474	191	3	formulation	formulation	NOUN
admet-1474	191	4	3	3	NUM
admet-1474	191	5	,	,	PUNCT
admet-1474	191	6	f4	f4	NOUN
admet-1474	191	7	=	=	SYM
admet-1474	191	8	formulation	formulation	NOUN
admet-1474	191	9	4	4	NUM
admet-1474	191	10	,	,	PUNCT
admet-1474	191	11	lc	lc	NOUN
admet-1474	191	12	=	=	PUNCT
admet-1474	191	13	levodopa	levodopa	NOUN
admet-1474	191	14	plus	plus	CCONJ
admet-1474	191	15	carbidopa	carbidopa	ADJ
admet-1474	191	16	powder	powder	NOUN
admet-1474	191	17	.	.	PUNCT
admet-1474	192	1	error	error	NOUN
admet-1474	192	2	bars	bar	NOUN
admet-1474	192	3	indicate	indicate	VERB
admet-1474	192	4	sd	sd	NOUN
admet-1474	192	5	.	.	PUNCT
admet-1474	193	1	polymers	polymer	NOUN
admet-1474	193	2	such	such	ADJ
admet-1474	193	3	as	as	ADP
admet-1474	193	4	alginate	alginate	NOUN
admet-1474	193	5	,	,	PUNCT
admet-1474	193	6	dextran	dextran	NOUN
admet-1474	193	7	,	,	PUNCT
admet-1474	193	8	pectin	pectin	NOUN
admet-1474	193	9	,	,	PUNCT
admet-1474	193	10	guar	guar	NOUN
admet-1474	193	11	gum	gum	NOUN
admet-1474	193	12	and	and	CCONJ
admet-1474	193	13	chitosan	chitosan	NOUN
admet-1474	193	14	have	have	AUX
admet-1474	193	15	been	be	AUX
admet-1474	193	16	employed	employ	VERB
admet-1474	193	17	to	to	PART
admet-1474	193	18	control	control	VERB
admet-1474	193	19	and	and	CCONJ
admet-1474	193	20	sustain	sustain	VERB
admet-1474	193	21	the	the	DET
admet-1474	193	22	release	release	NOUN
admet-1474	193	23	of	of	ADP
admet-1474	193	24	drugs	drug	NOUN
admet-1474	194	1	[	[	X
admet-1474	194	2	30,31	30,31	NOUN
admet-1474	194	3	]	]	PUNCT
admet-1474	194	4	.	.	PUNCT
admet-1474	195	1	in	in	ADP
admet-1474	195	2	this	this	DET
admet-1474	195	3	study	study	NOUN
admet-1474	195	4	,	,	PUNCT
admet-1474	195	5	chitosan	chitosan	NOUN
admet-1474	195	6	and	and	CCONJ
admet-1474	195	7	cph	cph	PROPN
admet-1474	195	8	pectin	pectin	NOUN
admet-1474	195	9	were	be	AUX
admet-1474	195	10	employed	employ	VERB
admet-1474	195	11	in	in	ADP
admet-1474	195	12	the	the	DET
admet-1474	195	13	formulation	formulation	NOUN
admet-1474	195	14	of	of	ADP
admet-1474	195	15	an	an	DET
admet-1474	195	16	oral	oral	ADJ
admet-1474	195	17	multiparticulate	multiparticulate	ADJ
admet-1474	195	18	matrix	matrix	NOUN
admet-1474	195	19	of	of	ADP
admet-1474	195	20	levodopa	levodopa	NOUN
admet-1474	195	21	and	and	CCONJ
admet-1474	195	22	carbidopa	carbidopa	NOUN
admet-1474	195	23	.	.	PUNCT
admet-1474	196	1	oral	oral	ADJ
admet-1474	196	2	multiparticulate	multiparticulate	ADJ
admet-1474	196	3	matrix	matrix	NOUN
admet-1474	196	4	systems	system	NOUN
admet-1474	196	5	have	have	AUX
admet-1474	196	6	been	be	AUX
admet-1474	196	7	proven	prove	VERB
admet-1474	196	8	suitable	suitable	ADJ
admet-1474	196	9	for	for	ADP
admet-1474	196	10	modified	modify	VERB
admet-1474	196	11	-	-	PUNCT
admet-1474	196	12	release	release	NOUN
admet-1474	196	13	formulations	formulation	NOUN
admet-1474	196	14	.	.	PUNCT
admet-1474	197	1	these	these	DET
admet-1474	197	2	granular	granular	ADJ
admet-1474	197	3	matrix	matrix	NOUN
admet-1474	197	4	systems	system	NOUN
admet-1474	197	5	are	be	AUX
admet-1474	197	6	also	also	ADV
admet-1474	197	7	known	know	VERB
admet-1474	197	8	to	to	PART
admet-1474	197	9	have	have	VERB
admet-1474	197	10	predictable	predictable	ADJ
admet-1474	197	11	gastrointestinal	gastrointestinal	ADJ
admet-1474	197	12	transport	transport	NOUN
admet-1474	197	13	and	and	CCONJ
admet-1474	197	14	a	a	DET
admet-1474	197	15	low	low	ADJ
admet-1474	197	16	risk	risk	NOUN
admet-1474	197	17	of	of	ADP
admet-1474	197	18	dose	dose	NOUN
admet-1474	197	19	dumping	dumping	NOUN
admet-1474	198	1	[	[	X
admet-1474	198	2	32,33	32,33	NUM
admet-1474	198	3	]	]	PUNCT
admet-1474	198	4	.	.	PUNCT
admet-1474	199	1	admet	admet	PROPN
admet-1474	199	2	&	&	CCONJ
admet-1474	199	3	dmpk	dmpk	PROPN
admet-1474	199	4	11(1	11(1	NUM
admet-1474	199	5	)	)	PUNCT
admet-1474	199	6	(	(	PUNCT
admet-1474	199	7	2023	2023	NUM
admet-1474	199	8	)	)	PUNCT
admet-1474	199	9	97	97	NUM
admet-1474	199	10	-	-	SYM
admet-1474	199	11	115	115	NUM
admet-1474	199	12	evaluation	evaluation	NOUN
admet-1474	199	13	of	of	ADP
admet-1474	199	14	re	re	ADJ
admet-1474	199	15	-	-	ADJ
admet-1474	199	16	formulated	formulate	VERB
admet-1474	199	17	levodopa	levodopa	NOUN
admet-1474	199	18	and	and	CCONJ
admet-1474	199	19	carbidopa	carbidopa	NOUN
admet-1474	199	20	doi	doi	NOUN
admet-1474	199	21	:	:	PUNCT
admet-1474	199	22	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	199	23	109	109	NUM
admet-1474	199	24	table	table	NOUN
admet-1474	199	25	5	5	NUM
admet-1474	199	26	.	.	PUNCT
admet-1474	199	27	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	199	28	parameters	parameter	NOUN
admet-1474	199	29	of	of	ADP
admet-1474	199	30	levodopa	levodopa	NOUN
admet-1474	199	31	in	in	ADP
admet-1474	199	32	the	the	DET
admet-1474	199	33	four	four	NUM
admet-1474	199	34	treatment	treatment	NOUN
admet-1474	199	35	groups	group	NOUN
admet-1474	199	36	(	(	PUNCT
admet-1474	199	37	±	±	NUM
admet-1474	199	38	sem	sem	NOUN
admet-1474	199	39	)	)	PUNCT
admet-1474	199	40	pk	pk	NOUN
admet-1474	199	41	parameter	parameter	NOUN
admet-1474	199	42	sinemet	sinemet	PROPN
admet-1474	199	43	®	®	PROPN
admet-1474	199	44	cr	cr	PROPN
admet-1474	199	45	f3	f3	VERB
admet-1474	199	46	f4	f4	PRON
admet-1474	199	47	lc	lc	NOUN
admet-1474	199	48	p	p	NOUN
admet-1474	199	49	-	-	PUNCT
admet-1474	199	50	value	value	NOUN
admet-1474	199	51	tmax	tmax	ADP
admet-1474	199	52	(	(	PUNCT
admet-1474	199	53	hr	hr	NOUN
admet-1474	199	54	)	)	PUNCT
admet-1474	199	55	0.9	0.9	NUM
admet-1474	199	56	(	(	PUNCT
admet-1474	199	57	0.22	0.22	NUM
admet-1474	199	58	)	)	PUNCT
admet-1474	199	59	4	4	NUM
admet-1474	199	60	(	(	PUNCT
admet-1474	199	61	0.00	0.00	NUM
admet-1474	199	62	)	)	PUNCT
admet-1474	199	63	4.4	4.4	NUM
admet-1474	199	64	(	(	PUNCT
admet-1474	199	65	2.19	2.19	NUM
admet-1474	199	66	)	)	PUNCT
admet-1474	199	67	0.40	0.40	NUM
admet-1474	199	68	(	(	PUNCT
admet-1474	199	69	0.34	0.34	NUM
admet-1474	199	70	)	)	PUNCT
admet-1474	199	71	<	<	X
admet-1474	199	72	0.0001	0.0001	NUM
admet-1474	199	73	cmax	cmax	NOUN
admet-1474	199	74	(	(	PUNCT
admet-1474	199	75	µg	µg	NOUN
admet-1474	199	76	/	/	SYM
admet-1474	199	77	ml	ml	VERB
admet-1474	199	78	)	)	PUNCT
admet-1474	199	79	30.62	30.62	NUM
admet-1474	199	80	(	(	PUNCT
admet-1474	199	81	3.37	3.37	NUM
admet-1474	199	82	)	)	PUNCT
admet-1474	199	83	36.28	36.28	NUM
admet-1474	199	84	(	(	PUNCT
admet-1474	199	85	1.52	1.52	NUM
admet-1474	199	86	)	)	PUNCT
admet-1474	199	87	34.80	34.80	NUM
admet-1474	199	88	(	(	PUNCT
admet-1474	199	89	2.19	2.19	NUM
admet-1474	199	90	)	)	PUNCT
admet-1474	199	91	24.00	24.00	NUM
admet-1474	199	92	(	(	PUNCT
admet-1474	199	93	2.42	2.42	NUM
admet-1474	199	94	)	)	PUNCT
admet-1474	199	95	<	<	X
admet-1474	199	96	0.0001	0.0001	NUM
admet-1474	199	97	auc0	auc0	PROPN
admet-1474	199	98	-	-	PUNCT
admet-1474	199	99	24	24	NUM
admet-1474	199	100	(	(	PUNCT
admet-1474	199	101	µg.hr/ml	µg.hr/ml	ADJ
admet-1474	199	102	)	)	PUNCT
admet-1474	199	103	262.84	262.84	NUM
admet-1474	199	104	(	(	PUNCT
admet-1474	199	105	16.73	16.73	NUM
admet-1474	199	106	)	)	PUNCT
admet-1474	199	107	484.98	484.98	NUM
admet-1474	199	108	(	(	PUNCT
admet-1474	199	109	18.70	18.70	NUM
admet-1474	199	110	)	)	PUNCT
admet-1474	199	111	535.60	535.60	NUM
admet-1474	199	112	(	(	PUNCT
admet-1474	199	113	33.04	33.04	NUM
admet-1474	199	114	)	)	PUNCT
admet-1474	199	115	252.39	252.39	NUM
admet-1474	199	116	(	(	PUNCT
admet-1474	199	117	135.47	135.47	NUM
admet-1474	199	118	)	)	PUNCT
admet-1474	199	119	<	<	X
admet-1474	199	120	0.0001	0.0001	NUM
admet-1474	199	121	auc0-∞	auc0-∞	NUM
admet-1474	199	122	(	(	PUNCT
admet-1474	199	123	µg.hr/ml	µg.hr/ml	ADJ
admet-1474	199	124	)	)	PUNCT
admet-1474	199	125	275.60	275.60	NUM
admet-1474	199	126	(	(	PUNCT
admet-1474	199	127	16.89	16.89	NUM
admet-1474	199	128	)	)	PUNCT
admet-1474	199	129	572.13	572.13	NUM
admet-1474	199	130	(	(	PUNCT
admet-1474	199	131	36.46	36.46	NUM
admet-1474	199	132	)	)	PUNCT
admet-1474	199	133	647.40	647.40	NUM
admet-1474	199	134	(	(	PUNCT
admet-1474	199	135	83.55	83.55	NUM
admet-1474	199	136	)	)	PUNCT
admet-1474	199	137	262.83	262.83	NUM
admet-1474	199	138	(	(	PUNCT
admet-1474	199	139	10.35	10.35	NUM
admet-1474	199	140	)	)	PUNCT
admet-1474	199	141	<	<	X
admet-1474	199	142	0.0001	0.0001	NUM
admet-1474	199	143	ke	ke	NOUN
admet-1474	199	144	(	(	PUNCT
admet-1474	199	145	1	1	NUM
admet-1474	199	146	/	/	SYM
admet-1474	199	147	hr	hr	NOUN
admet-1474	199	148	)	)	PUNCT
admet-1474	199	149	0.13	0.13	NUM
admet-1474	199	150	(	(	PUNCT
admet-1474	199	151	0.03	0.03	NUM
admet-1474	199	152	)	)	PUNCT
admet-1474	199	153	0.09	0.09	NUM
admet-1474	199	154	(	(	PUNCT
admet-1474	199	155	0.02	0.02	NUM
admet-1474	199	156	)	)	PUNCT
admet-1474	199	157	0.09	0.09	NUM
admet-1474	199	158	(	(	PUNCT
admet-1474	199	159	0.03	0.03	NUM
admet-1474	199	160	)	)	PUNCT
admet-1474	199	161	0.16	0.16	NUM
admet-1474	199	162	(	(	PUNCT
admet-1474	199	163	0.01	0.01	NUM
admet-1474	199	164	)	)	PUNCT
admet-1474	199	165	0.0003	0.0003	NUM
admet-1474	199	166	t1/2	t1/2	NOUN
admet-1474	199	167	(	(	PUNCT
admet-1474	199	168	hr	hr	NOUN
admet-1474	199	169	)	)	PUNCT
admet-1474	199	170	5.34	5.34	NUM
admet-1474	199	171	(	(	PUNCT
admet-1474	199	172	0.95	0.95	NUM
admet-1474	199	173	)	)	PUNCT
admet-1474	199	174	8.33	8.33	NUM
admet-1474	199	175	(	(	PUNCT
admet-1474	199	176	0.01	0.01	NUM
admet-1474	199	177	)	)	PUNCT
admet-1474	199	178	8.84	8.84	NUM
admet-1474	199	179	(	(	PUNCT
admet-1474	199	180	2.95	2.95	NUM
admet-1474	199	181	)	)	PUNCT
admet-1474	199	182	4.27	4.27	NUM
admet-1474	199	183	(	(	PUNCT
admet-1474	199	184	0.35	0.35	NUM
admet-1474	199	185	)	)	PUNCT
admet-1474	199	186	<	<	X
admet-1474	199	187	0.0001	0.0001	NUM
admet-1474	199	188	sinemet	sinemet	NOUN
admet-1474	199	189	®	®	NOUN
admet-1474	199	190	cr	cr	NOUN
admet-1474	199	191	=	=	PUNCT
admet-1474	199	192	a	a	DET
admet-1474	199	193	controlled	control	VERB
admet-1474	199	194	release	release	NOUN
admet-1474	199	195	formulation	formulation	NOUN
admet-1474	199	196	of	of	ADP
admet-1474	199	197	levodopa	levodopa	NOUN
admet-1474	199	198	/	/	SYM
admet-1474	199	199	carbidopa	carbidopa	NOUN
admet-1474	199	200	.	.	PUNCT
admet-1474	200	1	f3	f3	PROPN
admet-1474	200	2	=	=	SYM
admet-1474	200	3	formulation	formulation	NOUN
admet-1474	200	4	3	3	NUM
admet-1474	200	5	,	,	PUNCT
admet-1474	200	6	f4	f4	NOUN
admet-1474	200	7	=	=	SYM
admet-1474	200	8	formulation	formulation	NOUN
admet-1474	200	9	4	4	NUM
admet-1474	200	10	,	,	PUNCT
admet-1474	200	11	lc	lc	NOUN
admet-1474	200	12	=	=	PUNCT
admet-1474	200	13	levodopa	levodopa	NOUN
admet-1474	200	14	plus	plus	CCONJ
admet-1474	200	15	carbidopa	carbidopa	NOUN
admet-1474	200	16	powder	powder	NOUN
admet-1474	200	17	a	a	DET
admet-1474	200	18	number	number	NOUN
admet-1474	200	19	of	of	ADP
admet-1474	200	20	methods	method	NOUN
admet-1474	200	21	,	,	PUNCT
admet-1474	200	22	such	such	ADJ
admet-1474	200	23	as	as	ADP
admet-1474	200	24	differential	differential	ADJ
admet-1474	200	25	scanning	scanning	NOUN
admet-1474	200	26	calorimetry	calorimetry	NOUN
admet-1474	200	27	,	,	PUNCT
admet-1474	200	28	isothermal	isothermal	ADJ
admet-1474	200	29	stress	stress	NOUN
admet-1474	200	30	testing	testing	NOUN
admet-1474	200	31	and	and	CCONJ
admet-1474	200	32	ftir	ftir	PROPN
admet-1474	200	33	,	,	PUNCT
admet-1474	200	34	have	have	AUX
admet-1474	200	35	been	be	AUX
admet-1474	200	36	employed	employ	VERB
admet-1474	200	37	in	in	ADP
admet-1474	200	38	drug	drug	NOUN
admet-1474	200	39	-	-	PUNCT
admet-1474	200	40	excipient	excipient	NOUN
admet-1474	200	41	compatibility	compatibility	NOUN
admet-1474	200	42	studies	study	NOUN
admet-1474	200	43	.	.	PUNCT
admet-1474	201	1	among	among	ADP
admet-1474	201	2	these	these	DET
admet-1474	201	3	methods	method	NOUN
admet-1474	201	4	,	,	PUNCT
admet-1474	201	5	ftir	ftir	PROPN
admet-1474	201	6	was	be	AUX
admet-1474	201	7	found	find	VERB
admet-1474	201	8	to	to	PART
admet-1474	201	9	be	be	AUX
admet-1474	201	10	useful	useful	ADJ
admet-1474	201	11	in	in	ADP
admet-1474	201	12	providing	provide	VERB
admet-1474	201	13	information	information	NOUN
admet-1474	201	14	on	on	ADP
admet-1474	201	15	drug	drug	NOUN
admet-1474	201	16	/	/	SYM
admet-1474	201	17	excipient	excipient	NOUN
admet-1474	201	18	compatibility	compatibility	NOUN
admet-1474	202	1	[	[	X
admet-1474	202	2	34,35	34,35	NOUN
admet-1474	202	3	]	]	PUNCT
admet-1474	202	4	.	.	PUNCT
admet-1474	203	1	drug	drug	NOUN
admet-1474	203	2	-	-	PUNCT
admet-1474	203	3	excipients	excipient	NOUN
admet-1474	203	4	compatibility	compatibility	NOUN
admet-1474	203	5	test	test	NOUN
admet-1474	203	6	was	be	AUX
admet-1474	203	7	done	do	VERB
admet-1474	203	8	by	by	ADP
admet-1474	203	9	ftir	ftir	NOUN
admet-1474	203	10	in	in	ADP
admet-1474	203	11	order	order	NOUN
admet-1474	203	12	to	to	PART
admet-1474	203	13	predict	predict	VERB
admet-1474	203	14	any	any	DET
admet-1474	203	15	potential	potential	ADJ
admet-1474	203	16	chemical	chemical	NOUN
admet-1474	203	17	or	or	CCONJ
admet-1474	203	18	physical	physical	ADJ
admet-1474	203	19	interactions	interaction	NOUN
admet-1474	203	20	that	that	PRON
admet-1474	203	21	could	could	AUX
admet-1474	203	22	affect	affect	VERB
admet-1474	203	23	the	the	DET
admet-1474	203	24	quality	quality	NOUN
admet-1474	203	25	,	,	PUNCT
admet-1474	203	26	physicochemical	physicochemical	ADJ
admet-1474	203	27	properties	property	NOUN
admet-1474	203	28	and	and	CCONJ
admet-1474	203	29	release	release	NOUN
admet-1474	203	30	of	of	ADP
admet-1474	203	31	active	active	ADJ
admet-1474	203	32	pharmaceutical	pharmaceutical	ADJ
admet-1474	203	33	ingredients	ingredient	NOUN
admet-1474	203	34	[	[	X
admet-1474	203	35	36	36	NUM
admet-1474	203	36	]	]	PUNCT
admet-1474	203	37	.	.	PUNCT
admet-1474	204	1	in	in	ADP
admet-1474	204	2	the	the	DET
admet-1474	204	3	ftir	ftir	PROPN
admet-1474	204	4	spectrum	spectrum	NOUN
admet-1474	204	5	of	of	ADP
admet-1474	204	6	levodopa	levodopa	NOUN
admet-1474	204	7	,	,	PUNCT
admet-1474	204	8	characteristic	characteristic	ADJ
admet-1474	204	9	peaks	peak	NOUN
admet-1474	204	10	appearing	appear	VERB
admet-1474	204	11	between	between	ADP
admet-1474	204	12	3500	3500	NUM
admet-1474	204	13	cm-1	cm-1	NOUN
admet-1474	204	14	–	–	PUNCT
admet-1474	204	15	3200	3200	NUM
admet-1474	204	16	cm-1	cm-1	NOUN
admet-1474	204	17	show	show	VERB
admet-1474	204	18	o	o	PROPN
admet-1474	204	19	-	-	ADJ
admet-1474	204	20	h	h	ADJ
admet-1474	204	21	stretching	stretching	NOUN
admet-1474	204	22	.	.	PUNCT
admet-1474	205	1	bands	band	NOUN
admet-1474	205	2	between	between	ADP
admet-1474	205	3	3000	3000	NUM
admet-1474	205	4	cm-1	cm-1	NOUN
admet-1474	205	5	–	–	PUNCT
admet-1474	205	6	2850	2850	NUM
admet-1474	205	7	cm-1	cm-1	X
admet-1474	205	8	are	be	AUX
admet-1474	205	9	indicative	indicative	ADJ
admet-1474	205	10	of	of	ADP
admet-1474	205	11	symmetric	symmetric	ADJ
admet-1474	205	12	and	and	CCONJ
admet-1474	205	13	asymmetric	asymmetric	ADJ
admet-1474	205	14	-c	-c	ADJ
admet-1474	205	15	-	-	PUNCT
admet-1474	205	16	h	h	NOUN
admet-1474	205	17	stretches	stretch	NOUN
admet-1474	205	18	.	.	PUNCT
admet-1474	206	1	secondary	secondary	ADJ
admet-1474	206	2	amine	amine	ADJ
admet-1474	206	3	(	(	PUNCT
admet-1474	206	4	-nh2	-nh2	PROPN
admet-1474	206	5	)	)	PUNCT
admet-1474	206	6	stretches	stretch	NOUN
admet-1474	206	7	were	be	AUX
admet-1474	206	8	visible	visible	ADJ
admet-1474	206	9	at	at	ADP
admet-1474	206	10	1560	1560	NUM
admet-1474	206	11	cm-1	cm-1	NOUN
admet-1474	206	12	,	,	PUNCT
admet-1474	206	13	and	and	CCONJ
admet-1474	206	14	a	a	DET
admet-1474	206	15	sharp	sharp	ADJ
admet-1474	206	16	peak	peak	NOUN
admet-1474	206	17	at	at	ADP
admet-1474	206	18	1633	1633	NUM
admet-1474	206	19	cm-1	cm-1	PART
admet-1474	206	20	corresponded	correspond	VERB
admet-1474	206	21	to	to	ADP
admet-1474	206	22	the	the	DET
admet-1474	206	23	presence	presence	NOUN
admet-1474	206	24	of	of	ADP
admet-1474	206	25	a	a	DET
admet-1474	206	26	carbonyl	carbonyl	NOUN
admet-1474	206	27	(	(	PUNCT
admet-1474	206	28	c	c	NOUN
admet-1474	206	29	=	=	NOUN
admet-1474	206	30	o	o	NOUN
admet-1474	206	31	)	)	PUNCT
admet-1474	207	1	[	[	X
admet-1474	207	2	37	37	NUM
admet-1474	207	3	]	]	PUNCT
admet-1474	207	4	.	.	PUNCT
admet-1474	208	1	ftir	ftir	PROPN
admet-1474	208	2	spectrum	spectrum	PROPN
admet-1474	208	3	of	of	ADP
admet-1474	208	4	carbidopa	carbidopa	ADV
admet-1474	208	5	showed	show	VERB
admet-1474	208	6	visible	visible	ADJ
admet-1474	208	7	absorption	absorption	NOUN
admet-1474	208	8	bands	band	NOUN
admet-1474	208	9	between	between	ADP
admet-1474	208	10	3500	3500	NUM
admet-1474	208	11	-	-	SYM
admet-1474	208	12	3200	3200	NUM
admet-1474	208	13	cm-1	cm-1	NOUN
admet-1474	208	14	and	and	CCONJ
admet-1474	208	15	3100	3100	NUM
admet-1474	208	16	3000	3000	NUM
admet-1474	208	17	cm-1	cm-1	VERB
admet-1474	208	18	corresponding	correspond	VERB
admet-1474	208	19	to	to	ADP
admet-1474	208	20	o	o	NOUN
admet-1474	208	21	–	–	PUNCT
admet-1474	208	22	h	h	NOUN
admet-1474	208	23	stretches	stretch	NOUN
admet-1474	208	24	and	and	CCONJ
admet-1474	208	25	-c	-c	PROPN
admet-1474	208	26	–	–	PUNCT
admet-1474	208	27	h	h	NOUN
admet-1474	208	28	stretches	stretch	NOUN
admet-1474	208	29	,	,	PUNCT
admet-1474	208	30	respectively	respectively	ADV
admet-1474	208	31	.	.	PUNCT
admet-1474	208	32	carbonyl	carbonyl	NOUN
admet-1474	208	33	peak	peak	NOUN
admet-1474	208	34	was	be	AUX
admet-1474	208	35	visible	visible	ADJ
admet-1474	208	36	at	at	ADP
admet-1474	208	37	1627	1627	NUM
admet-1474	208	38	cm-1	cm-1	PROPN
admet-1474	208	39	,	,	PUNCT
admet-1474	208	40	nh2	nh2	PROPN
admet-1474	208	41	(	(	PUNCT
admet-1474	208	42	secondary	secondary	ADJ
admet-1474	208	43	amine	amine	ADJ
admet-1474	208	44	)	)	PUNCT
admet-1474	208	45	absorption	absorption	NOUN
admet-1474	208	46	band	band	NOUN
admet-1474	208	47	appeared	appear	VERB
admet-1474	208	48	at	at	ADP
admet-1474	208	49	1560	1560	NUM
admet-1474	208	50	cm-1	cm-1	NOUN
admet-1474	208	51	and	and	CCONJ
admet-1474	208	52	absorption	absorption	NOUN
admet-1474	208	53	bands	band	NOUN
admet-1474	208	54	appearing	appear	VERB
admet-1474	208	55	between	between	ADP
admet-1474	208	56	1450	1450	NUM
admet-1474	208	57	cm-1	cm-1	NOUN
admet-1474	208	58	1400	1400	NUM
admet-1474	208	59	cm-1	cm-1	VERB
admet-1474	208	60	corresponded	correspond	VERB
admet-1474	208	61	to	to	ADP
admet-1474	208	62	phenyl	phenyl	NOUN
admet-1474	208	63	group	group	NOUN
admet-1474	208	64	c	c	NOUN
admet-1474	208	65	=	=	NOUN
admet-1474	208	66	c	c	NOUN
admet-1474	208	67	vibrations	vibration	NOUN
admet-1474	208	68	[	[	X
admet-1474	208	69	38	38	NUM
admet-1474	208	70	]	]	PUNCT
admet-1474	208	71	.	.	PUNCT
admet-1474	209	1	the	the	DET
admet-1474	209	2	spectrum	spectrum	NOUN
admet-1474	209	3	of	of	ADP
admet-1474	209	4	chitosan	chitosan	NOUN
admet-1474	209	5	showed	show	VERB
admet-1474	209	6	characteristic	characteristic	ADJ
admet-1474	209	7	absorption	absorption	NOUN
admet-1474	209	8	bands	band	NOUN
admet-1474	209	9	of	of	ADP
admet-1474	209	10	c	c	NOUN
admet-1474	209	11	=	=	NOUN
admet-1474	209	12	o	o	NOUN
admet-1474	209	13	stretching	stretching	NOUN
admet-1474	209	14	and	and	CCONJ
admet-1474	209	15	amidic	amidic	ADJ
admet-1474	209	16	n	n	CCONJ
admet-1474	209	17	-	-	PUNCT
admet-1474	209	18	h	h	NOUN
admet-1474	209	19	bending	bending	NOUN
admet-1474	209	20	between	between	ADP
admet-1474	209	21	1700	1700	NUM
admet-1474	209	22	cm-1	cm-1	NOUN
admet-1474	209	23	1650	1650	NUM
admet-1474	209	24	cm−1	cm−1	NOUN
admet-1474	209	25	and	and	CCONJ
admet-1474	209	26	1500	1500	NUM
admet-1474	209	27	cm-1	cm-1	NOUN
admet-1474	209	28	-1400	-1400	PROPN
admet-1474	209	29	 	 	SPACE
admet-1474	209	30	cm−1	cm−1	NOUN
admet-1474	209	31	,	,	PUNCT
admet-1474	209	32	respectively	respectively	ADV
admet-1474	209	33	[	[	X
admet-1474	209	34	39	39	NUM
admet-1474	209	35	]	]	PUNCT
admet-1474	209	36	.	.	PUNCT
admet-1474	210	1	the	the	DET
admet-1474	210	2	spectrum	spectrum	NOUN
admet-1474	210	3	of	of	ADP
admet-1474	210	4	pectin	pectin	NOUN
admet-1474	210	5	showed	show	VERB
admet-1474	210	6	characteristic	characteristic	ADJ
admet-1474	210	7	peaks	peak	NOUN
admet-1474	210	8	as	as	SCONJ
admet-1474	210	9	previously	previously	ADV
admet-1474	210	10	described	describe	VERB
admet-1474	210	11	.	.	PUNCT
admet-1474	211	1	ftir	ftir	PROPN
admet-1474	211	2	results	result	NOUN
admet-1474	211	3	of	of	ADP
admet-1474	211	4	optimized	optimize	VERB
admet-1474	211	5	formulations	formulation	NOUN
admet-1474	211	6	(	(	PUNCT
admet-1474	211	7	f3	f3	PROPN
admet-1474	211	8	and	and	CCONJ
admet-1474	211	9	f4	f4	PROPN
admet-1474	211	10	)	)	PUNCT
admet-1474	211	11	showed	show	VERB
admet-1474	211	12	similar	similar	ADJ
admet-1474	211	13	peaks	peak	NOUN
admet-1474	211	14	for	for	ADP
admet-1474	211	15	the	the	DET
admet-1474	211	16	specific	specific	ADJ
admet-1474	211	17	functional	functional	ADJ
admet-1474	211	18	groups	group	NOUN
admet-1474	211	19	present	present	ADJ
admet-1474	211	20	in	in	ADP
admet-1474	211	21	levodopa	levodopa	NOUN
admet-1474	211	22	and	and	CCONJ
admet-1474	211	23	carbidopa	carbidopa	ADV
admet-1474	211	24	(	(	PUNCT
admet-1474	211	25	shown	show	VERB
admet-1474	211	26	in	in	ADP
admet-1474	211	27	figure	figure	NOUN
admet-1474	211	28	2	2	NUM
admet-1474	211	29	)	)	PUNCT
admet-1474	211	30	.	.	PUNCT
admet-1474	212	1	this	this	DET
admet-1474	212	2	finding	finding	NOUN
admet-1474	212	3	suggests	suggest	VERB
admet-1474	212	4	no	no	DET
admet-1474	212	5	structural	structural	ADJ
admet-1474	212	6	change	change	NOUN
admet-1474	212	7	or	or	CCONJ
admet-1474	212	8	interference	interference	VERB
admet-1474	212	9	to	to	PART
admet-1474	212	10	levodopa	levodopa	VERB
admet-1474	212	11	and	and	CCONJ
admet-1474	212	12	carbidopa	carbidopa	ADV
admet-1474	212	13	with	with	ADP
admet-1474	212	14	excipients	excipient	NOUN
admet-1474	212	15	used	use	VERB
admet-1474	212	16	.	.	PUNCT
admet-1474	213	1	previous	previous	ADJ
admet-1474	213	2	reports	report	NOUN
admet-1474	213	3	by	by	ADP
admet-1474	213	4	bigucci	bigucci	NOUN
admet-1474	213	5	et	et	PROPN
admet-1474	213	6	al	al	PROPN
admet-1474	213	7	.	.	PUNCT
admet-1474	214	1	[	[	X
admet-1474	214	2	39	39	NUM
admet-1474	214	3	]	]	PUNCT
admet-1474	214	4	and	and	CCONJ
admet-1474	214	5	gadalla	gadalla	PROPN
admet-1474	214	6	et	et	PROPN
admet-1474	214	7	al	al	PROPN
admet-1474	214	8	.	.	PUNCT
admet-1474	215	1	[	[	X
admet-1474	215	2	40	40	NUM
admet-1474	215	3	]	]	PUNCT
admet-1474	215	4	also	also	ADV
admet-1474	215	5	revealed	reveal	VERB
admet-1474	215	6	that	that	SCONJ
admet-1474	215	7	chitosan	chitosan	NOUN
admet-1474	215	8	and	and	CCONJ
admet-1474	215	9	pectin	pectin	NOUN
admet-1474	215	10	were	be	AUX
admet-1474	215	11	compatible	compatible	ADJ
admet-1474	215	12	with	with	ADP
admet-1474	215	13	vancomycin	vancomycin	PROPN
admet-1474	215	14	and	and	CCONJ
admet-1474	215	15	progesterone	progesterone	NOUN
admet-1474	215	16	,	,	PUNCT
admet-1474	215	17	respectively	respectively	ADV
admet-1474	215	18	.	.	PUNCT
admet-1474	216	1	in	in	ADP
admet-1474	216	2	drug	drug	NOUN
admet-1474	216	3	formulation	formulation	NOUN
admet-1474	216	4	,	,	PUNCT
admet-1474	216	5	the	the	DET
admet-1474	216	6	ease	ease	NOUN
admet-1474	216	7	of	of	ADP
admet-1474	216	8	flow	flow	NOUN
admet-1474	216	9	of	of	ADP
admet-1474	216	10	granular	granular	ADJ
admet-1474	216	11	powders	powder	NOUN
admet-1474	216	12	is	be	AUX
admet-1474	216	13	important	important	ADJ
admet-1474	216	14	.	.	PUNCT
admet-1474	217	1	this	this	PRON
admet-1474	217	2	is	be	AUX
admet-1474	217	3	because	because	SCONJ
admet-1474	217	4	free	free	ADJ
admet-1474	217	5	-	-	PUNCT
admet-1474	217	6	flowing	flow	VERB
admet-1474	217	7	powders	powder	NOUN
admet-1474	217	8	ensure	ensure	VERB
admet-1474	217	9	reproducible	reproducible	ADJ
admet-1474	217	10	dosator	dosator	NOUN
admet-1474	217	11	filling	fill	VERB
admet-1474	217	12	[	[	X
admet-1474	217	13	13,41	13,41	PROPN
admet-1474	217	14	]	]	PUNCT
admet-1474	217	15	.	.	PUNCT
admet-1474	218	1	the	the	DET
admet-1474	218	2	flow	flow	NOUN
admet-1474	218	3	and	and	CCONJ
admet-1474	218	4	precompression	precompression	NOUN
admet-1474	218	5	parameters	parameter	NOUN
admet-1474	218	6	of	of	ADP
admet-1474	218	7	the	the	DET
admet-1474	218	8	chitosan	chitosan	NOUN
admet-1474	218	9	-	-	PUNCT
admet-1474	218	10	pectin	pectin	NOUN
admet-1474	218	11	-	-	PUNCT
admet-1474	218	12	based	base	VERB
admet-1474	218	13	formulations	formulation	NOUN
admet-1474	218	14	studied	study	VERB
admet-1474	218	15	were	be	AUX
admet-1474	218	16	carr	carr	PROPN
admet-1474	218	17	’s	’s	PART
admet-1474	218	18	index	index	NOUN
admet-1474	218	19	,	,	PUNCT
admet-1474	218	20	hausner	hausner	NOUN
admet-1474	218	21	ratio	ratio	NOUN
admet-1474	218	22	,	,	PUNCT
admet-1474	218	23	and	and	CCONJ
admet-1474	218	24	angle	angle	NOUN
admet-1474	218	25	of	of	ADP
admet-1474	218	26	repose	repose	NOUN
admet-1474	218	27	.	.	PUNCT
admet-1474	219	1	for	for	ADP
admet-1474	219	2	the	the	DET
admet-1474	219	3	hausner	hausner	NOUN
admet-1474	219	4	ratio	ratio	NOUN
admet-1474	219	5	,	,	PUNCT
admet-1474	219	6	values	value	NOUN
admet-1474	219	7	close	close	ADJ
admet-1474	219	8	to	to	PART
admet-1474	219	9	1.2	1.2	NUM
admet-1474	219	10	suggest	suggest	VERB
admet-1474	219	11	free	free	ADV
admet-1474	219	12	-	-	PUNCT
admet-1474	219	13	flowing	flow	VERB
admet-1474	219	14	and	and	CCONJ
admet-1474	219	15	less	less	ADV
admet-1474	219	16	cohesive	cohesive	ADJ
admet-1474	219	17	powders	powder	NOUN
admet-1474	219	18	,	,	PUNCT
admet-1474	219	19	while	while	SCONJ
admet-1474	219	20	values	value	NOUN
admet-1474	219	21	greater	great	ADJ
admet-1474	219	22	than	than	ADP
admet-1474	219	23	1.6	1.6	NUM
admet-1474	219	24	indicate	indicate	VERB
admet-1474	219	25	cohesive	cohesive	ADJ
admet-1474	219	26	powders	powder	NOUN
admet-1474	219	27	with	with	ADP
admet-1474	219	28	poor	poor	ADJ
admet-1474	219	29	flowability	flowability	NOUN
admet-1474	220	1	[	[	X
admet-1474	220	2	42	42	NUM
admet-1474	220	3	]	]	PUNCT
admet-1474	220	4	.	.	PUNCT
admet-1474	221	1	carr	carr	PROPN
admet-1474	221	2	’s	’s	PART
admet-1474	221	3	compressibility	compressibility	NOUN
admet-1474	221	4	index	index	NOUN
admet-1474	221	5	above	above	ADP
admet-1474	221	6	32	32	NUM
admet-1474	221	7	and	and	CCONJ
admet-1474	221	8	angles	angle	NOUN
admet-1474	221	9	of	of	ADP
admet-1474	221	10	repose	repose	NOUN
admet-1474	221	11	above	above	ADP
admet-1474	221	12	35	35	NUM
admet-1474	221	13	°	°	NOUN
admet-1474	221	14	are	be	AUX
admet-1474	221	15	indicative	indicative	ADJ
admet-1474	221	16	of	of	ADP
admet-1474	221	17	powders	powder	NOUN
admet-1474	221	18	with	with	ADP
admet-1474	221	19	poor	poor	ADJ
admet-1474	221	20	and	and	CCONJ
admet-1474	221	21	unsatisfactory	unsatisfactory	ADJ
admet-1474	221	22	flow	flow	NOUN
admet-1474	221	23	properties	property	NOUN
admet-1474	221	24	[	[	X
admet-1474	221	25	43	43	NUM
admet-1474	221	26	]	]	PUNCT
admet-1474	221	27	.	.	PUNCT
admet-1474	222	1	in	in	ADP
admet-1474	222	2	this	this	DET
admet-1474	222	3	study	study	NOUN
admet-1474	222	4	,	,	PUNCT
admet-1474	222	5	formulations	formulation	NOUN
admet-1474	222	6	f1	f1	NOUN
admet-1474	222	7	,	,	PUNCT
admet-1474	222	8	f2	f2	PROPN
admet-1474	222	9	,	,	PUNCT
admet-1474	222	10	f3	f3	ADJ
admet-1474	222	11	,	,	PUNCT
admet-1474	222	12	f4	f4	ADJ
admet-1474	222	13	and	and	CCONJ
admet-1474	222	14	f5	f5	NOUN
admet-1474	222	15	were	be	AUX
admet-1474	222	16	found	find	VERB
admet-1474	222	17	to	to	PART
admet-1474	222	18	be	be	AUX
admet-1474	222	19	less	less	ADV
admet-1474	222	20	cohesive	cohesive	ADJ
admet-1474	222	21	and	and	CCONJ
admet-1474	222	22	had	have	VERB
admet-1474	222	23	satisfactory	satisfactory	ADJ
admet-1474	222	24	flow	flow	NOUN
admet-1474	222	25	properties	property	NOUN
admet-1474	222	26	.	.	PUNCT
admet-1474	223	1	according	accord	VERB
admet-1474	223	2	to	to	ADP
admet-1474	223	3	the	the	DET
admet-1474	223	4	united	united	PROPN
admet-1474	223	5	states	states	PROPN
admet-1474	223	6	pharmacopoeia	pharmacopoeia	NOUN
admet-1474	223	7	[	[	X
admet-1474	223	8	44	44	NUM
admet-1474	223	9	]	]	PUNCT
admet-1474	223	10	,	,	PUNCT
admet-1474	223	11	levodopa	levodopa	NOUN
admet-1474	223	12	and	and	CCONJ
admet-1474	223	13	carbidopa	carbidopa	NOUN
admet-1474	223	14	combination	combination	NOUN
admet-1474	223	15	should	should	AUX
admet-1474	223	16	contain	contain	VERB
admet-1474	223	17	not	not	PART
admet-1474	223	18	less	less	ADJ
admet-1474	223	19	than	than	ADP
admet-1474	223	20	90	90	NUM
admet-1474	223	21	%	%	NOUN
admet-1474	223	22	and	and	CCONJ
admet-1474	223	23	not	not	PART
admet-1474	223	24	more	more	ADJ
admet-1474	223	25	than	than	ADP
admet-1474	223	26	110	110	NUM
admet-1474	223	27	%	%	NOUN
admet-1474	223	28	of	of	ADP
admet-1474	223	29	the	the	DET
admet-1474	223	30	stated	state	VERB
admet-1474	223	31	amount	amount	NOUN
admet-1474	223	32	of	of	ADP
admet-1474	223	33	levodopa	levodopa	NOUN
admet-1474	223	34	and	and	CCONJ
admet-1474	223	35	carbidopa	carbidopa	NOUN
admet-1474	223	36	.	.	PUNCT
admet-1474	224	1	in	in	ADP
admet-1474	224	2	the	the	DET
admet-1474	224	3	current	current	ADJ
admet-1474	224	4	study	study	NOUN
admet-1474	224	5	,	,	PUNCT
admet-1474	224	6	the	the	DET
admet-1474	224	7	content	content	NOUN
admet-1474	224	8	of	of	ADP
admet-1474	224	9	levodopa	levodopa	NOUN
admet-1474	224	10	and	and	CCONJ
admet-1474	224	11	carbidopa	carbidopa	NOUN
admet-1474	224	12	in	in	ADP
admet-1474	224	13	all	all	DET
admet-1474	224	14	formulations	formulation	NOUN
admet-1474	224	15	with	with	ADP
admet-1474	224	16	the	the	DET
admet-1474	224	17	exception	exception	NOUN
admet-1474	224	18	of	of	ADP
admet-1474	224	19	f5	f5	NOUN
admet-1474	224	20	,	,	PUNCT
admet-1474	224	21	were	be	AUX
admet-1474	224	22	within	within	ADP
admet-1474	224	23	the	the	DET
admet-1474	224	24	stated	state	VERB
admet-1474	224	25	acceptance	acceptance	NOUN
admet-1474	224	26	criteria	criterion	NOUN
admet-1474	224	27	.	.	PUNCT
admet-1474	225	1	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	225	2	emelia	emelia	PROPN
admet-1474	225	3	priscilla	priscilla	PROPN
admet-1474	225	4	imbeah	imbeah	PROPN
admet-1474	225	5	et	et	PROPN
admet-1474	225	6	al	al	PROPN
admet-1474	225	7	.	.	PROPN
admet-1474	225	8	admet	admet	PROPN
admet-1474	225	9	&	&	CCONJ
admet-1474	225	10	dmpk	dmpk	PROPN
admet-1474	225	11	11(1	11(1	NUM
admet-1474	225	12	)	)	PUNCT
admet-1474	225	13	(	(	PUNCT
admet-1474	225	14	2023	2023	NUM
admet-1474	225	15	)	)	PUNCT
admet-1474	225	16	97	97	NUM
admet-1474	225	17	-	-	SYM
admet-1474	225	18	115	115	NUM
admet-1474	225	19	110	110	NUM
admet-1474	225	20	the	the	DET
admet-1474	225	21	in	in	ADP
admet-1474	225	22	vitro	vitro	X
admet-1474	225	23	drug	drug	NOUN
admet-1474	225	24	release	release	NOUN
admet-1474	225	25	in	in	ADP
admet-1474	225	26	phosphate	phosphate	ADJ
admet-1474	225	27	buffer	buffer	NOUN
admet-1474	225	28	was	be	AUX
admet-1474	225	29	conducted	conduct	VERB
admet-1474	225	30	to	to	PART
admet-1474	225	31	mimic	mimic	VERB
admet-1474	225	32	the	the	DET
admet-1474	225	33	physiological	physiological	ADJ
admet-1474	225	34	gastrointestinal	gastrointestinal	ADJ
admet-1474	225	35	environment	environment	NOUN
admet-1474	225	36	[	[	X
admet-1474	225	37	10,19	10,19	NUM
admet-1474	225	38	]	]	X
admet-1474	225	39	.	.	PUNCT
admet-1474	226	1	the	the	DET
admet-1474	226	2	release	release	NOUN
admet-1474	226	3	of	of	ADP
admet-1474	226	4	the	the	DET
admet-1474	226	5	levodopa	levodopa	NOUN
admet-1474	226	6	from	from	ADP
admet-1474	226	7	the	the	DET
admet-1474	226	8	matrix	matrix	NOUN
admet-1474	226	9	was	be	AUX
admet-1474	226	10	found	find	VERB
admet-1474	226	11	to	to	PART
admet-1474	226	12	be	be	AUX
admet-1474	226	13	controlled	control	VERB
admet-1474	226	14	and	and	CCONJ
admet-1474	226	15	sustained	sustain	VERB
admet-1474	226	16	over	over	ADP
admet-1474	226	17	24	24	NUM
admet-1474	226	18	hr	hr	NOUN
admet-1474	226	19	.	.	PUNCT
admet-1474	227	1	as	as	SCONJ
admet-1474	227	2	shown	show	VERB
admet-1474	227	3	in	in	ADP
admet-1474	227	4	figure	figure	NOUN
admet-1474	227	5	3	3	NUM
admet-1474	227	6	,	,	PUNCT
admet-1474	227	7	levodopa	levodopa	NOUN
admet-1474	227	8	was	be	AUX
admet-1474	227	9	rapidly	rapidly	ADV
admet-1474	227	10	released	release	VERB
admet-1474	227	11	from	from	ADP
admet-1474	227	12	formulation	formulation	NOUN
admet-1474	227	13	f1	f1	NOUN
admet-1474	227	14	(	(	PUNCT
admet-1474	227	15	only	only	ADV
admet-1474	227	16	chitosan	chitosan	NOUN
admet-1474	227	17	)	)	PUNCT
admet-1474	227	18	and	and	CCONJ
admet-1474	227	19	formulation	formulation	NOUN
admet-1474	227	20	f2	f2	PROPN
admet-1474	227	21	(	(	PUNCT
admet-1474	227	22	100	100	NUM
admet-1474	227	23	mg	mg	ADP
admet-1474	227	24	chitosan	chitosan	NOUN
admet-1474	227	25	and	and	CCONJ
admet-1474	227	26	50	50	NUM
admet-1474	227	27	mg	mg	PROPN
admet-1474	227	28	pectin	pectin	PROPN
admet-1474	227	29	)	)	PUNCT
admet-1474	227	30	.	.	PUNCT
admet-1474	228	1	increasing	increase	VERB
admet-1474	228	2	the	the	DET
admet-1474	228	3	amount	amount	NOUN
admet-1474	228	4	of	of	ADP
admet-1474	228	5	pectin	pectin	NOUN
admet-1474	228	6	in	in	ADP
admet-1474	228	7	f3	f3	PROPN
admet-1474	228	8	(	(	PUNCT
admet-1474	228	9	containing	contain	VERB
admet-1474	228	10	100	100	NUM
admet-1474	228	11	mg	mg	ADP
admet-1474	228	12	chitosan	chitosan	NOUN
admet-1474	228	13	and	and	CCONJ
admet-1474	228	14	100	100	NUM
admet-1474	228	15	mg	mg	PROPN
admet-1474	228	16	pectin	pectin	PROPN
admet-1474	228	17	)	)	PUNCT
admet-1474	228	18	resulted	result	VERB
admet-1474	228	19	in	in	ADP
admet-1474	228	20	a	a	DET
admet-1474	228	21	reduced	reduce	VERB
admet-1474	228	22	release	release	NOUN
admet-1474	228	23	rate	rate	NOUN
admet-1474	228	24	of	of	ADP
admet-1474	228	25	levodopa	levodopa	NOUN
admet-1474	228	26	from	from	ADP
admet-1474	228	27	the	the	DET
admet-1474	228	28	chitosan	chitosan	NOUN
admet-1474	228	29	-	-	PUNCT
admet-1474	228	30	pectin	pectin	NOUN
admet-1474	228	31	matrix	matrix	NOUN
admet-1474	228	32	.	.	PUNCT
admet-1474	229	1	these	these	DET
admet-1474	229	2	results	result	NOUN
admet-1474	229	3	are	be	AUX
admet-1474	229	4	consistent	consistent	ADJ
admet-1474	229	5	with	with	ADP
admet-1474	229	6	those	those	PRON
admet-1474	229	7	of	of	ADP
admet-1474	229	8	el	el	PROPN
admet-1474	229	9	-	-	PROPN
admet-1474	229	10	gibaly	gibaly	NOUN
admet-1474	230	1	[	[	X
admet-1474	230	2	44	44	NUM
admet-1474	230	3	]	]	PUNCT
admet-1474	230	4	,	,	PUNCT
admet-1474	230	5	who	who	PRON
admet-1474	230	6	also	also	ADV
admet-1474	230	7	reported	report	VERB
admet-1474	230	8	a	a	DET
admet-1474	230	9	more	more	ADV
admet-1474	230	10	delayed	delay	VERB
admet-1474	230	11	release	release	NOUN
admet-1474	230	12	of	of	ADP
admet-1474	230	13	drug	drug	NOUN
admet-1474	230	14	when	when	SCONJ
admet-1474	230	15	the	the	DET
admet-1474	230	16	concentration	concentration	NOUN
admet-1474	230	17	of	of	ADP
admet-1474	230	18	pectin	pectin	NOUN
admet-1474	230	19	in	in	ADP
admet-1474	230	20	a	a	DET
admet-1474	230	21	matrix	matrix	NOUN
admet-1474	230	22	was	be	AUX
admet-1474	230	23	increased	increase	VERB
admet-1474	230	24	.	.	PUNCT
admet-1474	231	1	the	the	DET
admet-1474	231	2	addition	addition	NOUN
admet-1474	231	3	of	of	ADP
admet-1474	231	4	hydroxyapatite	hydroxyapatite	NOUN
admet-1474	231	5	and	and	CCONJ
admet-1474	231	6	calcium	calcium	NOUN
admet-1474	231	7	chloride	chloride	NOUN
admet-1474	231	8	salts	salt	NOUN
admet-1474	231	9	to	to	ADP
admet-1474	231	10	the	the	DET
admet-1474	231	11	chitosan	chitosan	NOUN
admet-1474	231	12	-	-	PUNCT
admet-1474	231	13	pectin	pectin	NOUN
admet-1474	231	14	matrix	matrix	NOUN
admet-1474	231	15	as	as	SCONJ
admet-1474	231	16	seen	see	VERB
admet-1474	231	17	in	in	ADP
admet-1474	231	18	f4	f4	PROPN
admet-1474	231	19	(	(	PUNCT
admet-1474	231	20	100	100	NUM
admet-1474	231	21	mg	mg	ADP
admet-1474	231	22	chitosan	chitosan	NOUN
admet-1474	231	23	,	,	PUNCT
admet-1474	231	24	100	100	NUM
admet-1474	231	25	mg	mg	NOUN
admet-1474	231	26	pectin	pectin	NOUN
admet-1474	231	27	and	and	CCONJ
admet-1474	231	28	10	10	NUM
admet-1474	231	29	mg	mg	NUM
admet-1474	231	30	hydroxyapatite	hydroxyapatite	NOUN
admet-1474	231	31	)	)	PUNCT
admet-1474	231	32	and	and	CCONJ
admet-1474	231	33	f5	f5	NOUN
admet-1474	231	34	(	(	PUNCT
admet-1474	231	35	100	100	NUM
admet-1474	231	36	mg	mg	ADP
admet-1474	231	37	chitosan	chitosan	NOUN
admet-1474	231	38	,	,	PUNCT
admet-1474	231	39	100	100	NUM
admet-1474	231	40	mg	mg	NOUN
admet-1474	231	41	pectin	pectin	NOUN
admet-1474	231	42	and	and	CCONJ
admet-1474	231	43	50	50	NUM
admet-1474	231	44	mg	mg	NOUN
admet-1474	231	45	cacl2	cacl2	NOUN
admet-1474	231	46	)	)	PUNCT
admet-1474	231	47	further	far	ADV
admet-1474	231	48	delayed	delay	VERB
admet-1474	231	49	the	the	DET
admet-1474	231	50	release	release	NOUN
admet-1474	231	51	of	of	ADP
admet-1474	231	52	both	both	DET
admet-1474	231	53	levodopa	levodopa	NOUN
admet-1474	231	54	and	and	CCONJ
admet-1474	231	55	carbidopa	carbidopa	NOUN
admet-1474	231	56	from	from	ADP
admet-1474	231	57	these	these	DET
admet-1474	231	58	formulations	formulation	NOUN
admet-1474	231	59	.	.	PUNCT
admet-1474	232	1	hydroxyapatite	hydroxyapatite	NOUN
admet-1474	232	2	is	be	AUX
admet-1474	232	3	a	a	DET
admet-1474	232	4	calcium	calcium	NOUN
admet-1474	232	5	-	-	PUNCT
admet-1474	232	6	rich	rich	ADJ
admet-1474	232	7	mineral	mineral	NOUN
admet-1474	232	8	.	.	PUNCT
admet-1474	233	1	calcium	calcium	NOUN
admet-1474	233	2	ions	ion	NOUN
admet-1474	233	3	serve	serve	VERB
admet-1474	233	4	as	as	ADP
admet-1474	233	5	cross	cross	ADJ
admet-1474	233	6	-	-	ADJ
admet-1474	233	7	linking	link	VERB
admet-1474	233	8	agents	agent	NOUN
admet-1474	233	9	for	for	ADP
admet-1474	233	10	pectin	pectin	NOUN
admet-1474	233	11	and	and	CCONJ
admet-1474	233	12	earlier	early	ADJ
admet-1474	233	13	reports	report	NOUN
admet-1474	233	14	suggest	suggest	VERB
admet-1474	233	15	that	that	SCONJ
admet-1474	233	16	the	the	DET
admet-1474	233	17	binding	binding	NOUN
admet-1474	233	18	of	of	ADP
admet-1474	233	19	calcium	calcium	NOUN
admet-1474	233	20	ions	ion	NOUN
admet-1474	233	21	with	with	ADP
admet-1474	233	22	pectin	pectin	NOUN
admet-1474	233	23	delay	delay	NOUN
admet-1474	233	24	drug	drug	NOUN
admet-1474	233	25	release	release	NOUN
admet-1474	233	26	and	and	CCONJ
admet-1474	233	27	increase	increase	VERB
admet-1474	233	28	the	the	DET
admet-1474	233	29	gel	gel	NOUN
admet-1474	233	30	strength	strength	NOUN
admet-1474	233	31	of	of	ADP
admet-1474	233	32	polymer	polymer	NOUN
admet-1474	233	33	matrices	matrix	NOUN
admet-1474	233	34	[	[	X
admet-1474	233	35	45–47	45–47	NUM
admet-1474	233	36	]	]	PUNCT
admet-1474	233	37	.	.	PUNCT
admet-1474	234	1	findings	finding	NOUN
admet-1474	234	2	from	from	ADP
admet-1474	234	3	the	the	DET
admet-1474	234	4	in	in	X
admet-1474	234	5	vitro	vitro	X
admet-1474	234	6	drug	drug	NOUN
admet-1474	234	7	release	release	NOUN
admet-1474	234	8	profiles	profile	NOUN
admet-1474	234	9	of	of	ADP
admet-1474	234	10	f4	f4	NOUN
admet-1474	234	11	and	and	CCONJ
admet-1474	234	12	f5	f5	NOUN
admet-1474	234	13	also	also	ADV
admet-1474	234	14	suggested	suggest	VERB
admet-1474	234	15	that	that	SCONJ
admet-1474	234	16	calcium	calcium	NOUN
admet-1474	234	17	ions	ion	NOUN
admet-1474	234	18	from	from	ADP
admet-1474	234	19	cacl2	cacl2	NOUN
admet-1474	234	20	provided	provide	VERB
admet-1474	234	21	better	well	ADJ
admet-1474	234	22	cross	cross	VERB
admet-1474	234	23	-	-	ADJ
admet-1474	234	24	linking	link	VERB
admet-1474	234	25	with	with	ADP
admet-1474	234	26	pectin	pectin	NOUN
admet-1474	234	27	than	than	ADP
admet-1474	234	28	hydroxyapatite	hydroxyapatite	NOUN
admet-1474	234	29	.	.	PUNCT
admet-1474	235	1	the	the	DET
admet-1474	235	2	release	release	NOUN
admet-1474	235	3	profile	profile	NOUN
admet-1474	235	4	of	of	ADP
admet-1474	235	5	f5	f5	NOUN
admet-1474	235	6	,	,	PUNCT
admet-1474	235	7	was	be	AUX
admet-1474	235	8	,	,	PUNCT
admet-1474	235	9	however	however	ADV
admet-1474	235	10	,	,	PUNCT
admet-1474	235	11	unsatisfactory	unsatisfactory	ADJ
admet-1474	235	12	,	,	PUNCT
admet-1474	235	13	as	as	SCONJ
admet-1474	235	14	only	only	ADV
admet-1474	235	15	77.8	77.8	NUM
admet-1474	235	16	%	%	NOUN
admet-1474	235	17	of	of	ADP
admet-1474	235	18	levodopa	levodopa	NOUN
admet-1474	235	19	was	be	AUX
admet-1474	235	20	released	release	VERB
admet-1474	235	21	from	from	ADP
admet-1474	235	22	the	the	DET
admet-1474	235	23	multiparticulate	multiparticulate	ADJ
admet-1474	235	24	matrix	matrix	NOUN
admet-1474	235	25	.	.	PUNCT
admet-1474	236	1	in	in	ADP
admet-1474	236	2	comparison	comparison	NOUN
admet-1474	236	3	with	with	ADP
admet-1474	236	4	sinemet	sinemet	PROPN
admet-1474	236	5	®	®	PROPN
admet-1474	236	6	cr	cr	PROPN
admet-1474	236	7	,	,	PUNCT
admet-1474	236	8	the	the	DET
admet-1474	236	9	release	release	NOUN
admet-1474	236	10	of	of	ADP
admet-1474	236	11	levodopa	levodopa	NOUN
admet-1474	236	12	from	from	ADP
admet-1474	236	13	the	the	DET
admet-1474	236	14	new	new	ADJ
admet-1474	236	15	formulation	formulation	NOUN
admet-1474	236	16	was	be	AUX
admet-1474	236	17	found	find	VERB
admet-1474	236	18	to	to	PART
admet-1474	236	19	be	be	AUX
admet-1474	236	20	biphasic	biphasic	ADJ
admet-1474	236	21	,	,	PUNCT
admet-1474	236	22	with	with	ADP
admet-1474	236	23	an	an	DET
admet-1474	236	24	averagely	averagely	NOUN
admet-1474	236	25	of	of	ADP
admet-1474	236	26	50	50	NUM
admet-1474	236	27	%	%	NOUN
admet-1474	236	28	of	of	ADP
admet-1474	236	29	the	the	DET
admet-1474	236	30	drug	drug	NOUN
admet-1474	236	31	released	release	VERB
admet-1474	236	32	in	in	ADP
admet-1474	236	33	the	the	DET
admet-1474	236	34	first	first	ADJ
admet-1474	236	35	1	1	NUM
admet-1474	236	36	hr	hr	NOUN
admet-1474	236	37	(	(	PUNCT
admet-1474	236	38	as	as	ADP
admet-1474	236	39	against	against	ADP
admet-1474	236	40	∼	∼	NOUN
admet-1474	236	41	12	12	NUM
admet-1474	236	42	%	%	NOUN
admet-1474	236	43	for	for	ADP
admet-1474	236	44	sinemet	sinemet	PROPN
admet-1474	236	45	®	®	PROPN
admet-1474	236	46	cr	cr	PROPN
admet-1474	236	47	)	)	PUNCT
admet-1474	236	48	and	and	CCONJ
admet-1474	236	49	the	the	DET
admet-1474	236	50	remaining	remain	VERB
admet-1474	236	51	drug	drug	NOUN
admet-1474	236	52	released	release	VERB
admet-1474	236	53	in	in	ADP
admet-1474	236	54	a	a	DET
admet-1474	236	55	controlled	control	VERB
admet-1474	236	56	fashion	fashion	NOUN
admet-1474	236	57	over	over	ADP
admet-1474	236	58	the	the	DET
admet-1474	236	59	next	next	ADJ
admet-1474	236	60	24	24	NUM
admet-1474	236	61	hr	hr	NOUN
admet-1474	236	62	.	.	PUNCT
admet-1474	237	1	in	in	ADP
admet-1474	237	2	biphasic	biphasic	ADJ
admet-1474	237	3	oral	oral	ADJ
admet-1474	237	4	drug	drug	NOUN
admet-1474	237	5	delivery	delivery	NOUN
admet-1474	237	6	systems	system	NOUN
admet-1474	237	7	,	,	PUNCT
admet-1474	237	8	the	the	DET
admet-1474	237	9	immediate	immediate	ADJ
admet-1474	237	10	release	release	NOUN
admet-1474	237	11	component	component	NOUN
admet-1474	237	12	provides	provide	VERB
admet-1474	237	13	the	the	DET
admet-1474	237	14	loading	loading	NOUN
admet-1474	237	15	dose	dose	NOUN
admet-1474	237	16	while	while	SCONJ
admet-1474	237	17	the	the	DET
admet-1474	237	18	sustained	sustain	VERB
admet-1474	237	19	release	release	NOUN
admet-1474	237	20	portion	portion	NOUN
admet-1474	237	21	maintains	maintain	VERB
admet-1474	237	22	effective	effective	ADJ
admet-1474	237	23	plasma	plasma	NOUN
admet-1474	237	24	drug	drug	NOUN
admet-1474	237	25	concentration	concentration	NOUN
admet-1474	237	26	over	over	ADP
admet-1474	237	27	time	time	NOUN
admet-1474	238	1	[	[	X
admet-1474	238	2	46,48,49	46,48,49	X
admet-1474	238	3	]	]	X
admet-1474	238	4	.	.	PUNCT
admet-1474	239	1	the	the	DET
admet-1474	239	2	release	release	NOUN
admet-1474	239	3	of	of	ADP
admet-1474	239	4	carbidopa	carbidopa	NOUN
admet-1474	239	5	from	from	ADP
admet-1474	239	6	the	the	DET
admet-1474	239	7	chitosan	chitosan	NOUN
admet-1474	239	8	-	-	PUNCT
admet-1474	239	9	pectin	pectin	NOUN
admet-1474	239	10	multiparticulate	multiparticulate	NOUN
admet-1474	239	11	matrix	matrix	NOUN
admet-1474	239	12	and	and	CCONJ
admet-1474	239	13	sinemet	sinemet	PROPN
admet-1474	239	14	®	®	NOUN
admet-1474	239	15	cr	cr	PROPN
admet-1474	239	16	increased	increase	VERB
admet-1474	239	17	gradually	gradually	ADV
admet-1474	239	18	over	over	ADP
admet-1474	239	19	4	4	NUM
admet-1474	239	20	hr	hr	NOUN
admet-1474	239	21	and	and	CCONJ
admet-1474	239	22	5	5	NUM
admet-1474	239	23	hr	hr	NOUN
admet-1474	239	24	,	,	PUNCT
admet-1474	239	25	respectively	respectively	ADV
admet-1474	239	26	,	,	PUNCT
admet-1474	239	27	and	and	CCONJ
admet-1474	239	28	declined	decline	VERB
admet-1474	239	29	sharply	sharply	ADV
admet-1474	239	30	beyond	beyond	ADP
admet-1474	239	31	these	these	DET
admet-1474	239	32	time	time	NOUN
admet-1474	239	33	points	point	NOUN
admet-1474	239	34	.	.	PUNCT
admet-1474	240	1	this	this	DET
admet-1474	240	2	finding	finding	NOUN
admet-1474	240	3	was	be	AUX
admet-1474	240	4	found	find	VERB
admet-1474	240	5	to	to	PART
admet-1474	240	6	be	be	AUX
admet-1474	240	7	consistent	consistent	ADJ
admet-1474	240	8	with	with	ADP
admet-1474	240	9	earlier	early	ADJ
admet-1474	240	10	reports	report	NOUN
admet-1474	240	11	[	[	X
admet-1474	240	12	19	19	NUM
admet-1474	240	13	]	]	PUNCT
admet-1474	240	14	.	.	PUNCT
admet-1474	241	1	carbidopa	carbidopa	PROPN
admet-1474	241	2	is	be	AUX
admet-1474	241	3	reported	report	VERB
admet-1474	241	4	to	to	PART
admet-1474	241	5	be	be	AUX
admet-1474	241	6	unstable	unstable	ADJ
admet-1474	241	7	at	at	ADP
admet-1474	241	8	ph	ph	PROPN
admet-1474	241	9	6.8	6.8	NUM
admet-1474	242	1	[	[	X
admet-1474	242	2	21	21	NUM
admet-1474	242	3	]	]	PUNCT
admet-1474	242	4	.	.	PUNCT
admet-1474	243	1	hence	hence	ADV
admet-1474	243	2	,	,	PUNCT
admet-1474	243	3	significant	significant	ADJ
admet-1474	243	4	degradation	degradation	NOUN
admet-1474	243	5	might	might	AUX
admet-1474	243	6	have	have	AUX
admet-1474	243	7	occurred	occur	VERB
admet-1474	243	8	during	during	ADP
admet-1474	243	9	the	the	DET
admet-1474	243	10	in	in	ADV
admet-1474	243	11	vitro	vitro	X
admet-1474	243	12	drug	drug	NOUN
admet-1474	243	13	release	release	NOUN
admet-1474	243	14	studies	study	NOUN
admet-1474	243	15	(	(	PUNCT
admet-1474	243	16	figure	figure	NOUN
admet-1474	243	17	3b	3b	NUM
admet-1474	243	18	)	)	PUNCT
admet-1474	243	19	.	.	PUNCT
admet-1474	244	1	based	base	VERB
admet-1474	244	2	on	on	ADP
admet-1474	244	3	the	the	DET
admet-1474	244	4	aforementioned	aforementioned	ADJ
admet-1474	244	5	content	content	NOUN
admet-1474	244	6	analysis	analysis	NOUN
admet-1474	244	7	and	and	CCONJ
admet-1474	244	8	drug	drug	NOUN
admet-1474	244	9	release	release	NOUN
admet-1474	244	10	profiles	profile	NOUN
admet-1474	244	11	of	of	ADP
admet-1474	244	12	the	the	DET
admet-1474	244	13	five	five	NUM
admet-1474	244	14	chitosan	chitosan	ADJ
admet-1474	244	15	-	-	PUNCT
admet-1474	244	16	pectinbased	pectinbase	VERB
admet-1474	244	17	formulations	formulation	NOUN
admet-1474	244	18	(	(	PUNCT
admet-1474	244	19	f1	f1	NOUN
admet-1474	244	20	,	,	PUNCT
admet-1474	244	21	f2	f2	PROPN
admet-1474	244	22	,	,	PUNCT
admet-1474	244	23	f3	f3	ADJ
admet-1474	244	24	,	,	PUNCT
admet-1474	244	25	f4	f4	ADJ
admet-1474	244	26	and	and	CCONJ
admet-1474	244	27	f5	f5	NOUN
admet-1474	244	28	)	)	PUNCT
admet-1474	244	29	,	,	PUNCT
admet-1474	244	30	formulations	formulation	NOUN
admet-1474	244	31	3	3	NUM
admet-1474	244	32	and	and	CCONJ
admet-1474	244	33	4	4	NUM
admet-1474	244	34	were	be	AUX
admet-1474	244	35	selected	select	VERB
admet-1474	244	36	as	as	SCONJ
admet-1474	244	37	optimized	optimize	VERB
admet-1474	244	38	for	for	ADP
admet-1474	244	39	further	further	ADJ
admet-1474	244	40	investigations	investigation	NOUN
admet-1474	244	41	.	.	PUNCT
admet-1474	245	1	the	the	DET
admet-1474	245	2	release	release	NOUN
admet-1474	245	3	patterns	pattern	NOUN
admet-1474	245	4	of	of	ADP
admet-1474	245	5	levodopa	levodopa	NOUN
admet-1474	245	6	and	and	CCONJ
admet-1474	245	7	carbidopa	carbidopa	NOUN
admet-1474	245	8	in	in	ADP
admet-1474	245	9	the	the	DET
admet-1474	245	10	optimized	optimize	VERB
admet-1474	245	11	formulations	formulation	NOUN
admet-1474	245	12	(	(	PUNCT
admet-1474	245	13	f3	f3	PROPN
admet-1474	245	14	and	and	CCONJ
admet-1474	245	15	f4	f4	NUM
admet-1474	245	16	)	)	PUNCT
admet-1474	245	17	were	be	AUX
admet-1474	245	18	further	far	ADV
admet-1474	245	19	investigated	investigate	VERB
admet-1474	245	20	in	in	ADP
admet-1474	245	21	phosphate	phosphate	ADJ
admet-1474	245	22	buffer	buffer	NOUN
admet-1474	245	23	(	(	PUNCT
admet-1474	245	24	ph	ph	NOUN
admet-1474	245	25	4.5	4.5	NUM
admet-1474	245	26	)	)	PUNCT
admet-1474	245	27	,	,	PUNCT
admet-1474	245	28	mimicking	mimic	VERB
admet-1474	245	29	the	the	DET
admet-1474	245	30	conditions	condition	NOUN
admet-1474	245	31	of	of	ADP
admet-1474	245	32	the	the	DET
admet-1474	245	33	duodenum	duodenum	ADJ
admet-1474	245	34	-	-	PUNCT
admet-1474	245	35	jejunal	jejunal	ADJ
admet-1474	245	36	region	region	NOUN
admet-1474	245	37	of	of	ADP
admet-1474	245	38	the	the	DET
admet-1474	245	39	gastrointestinal	gastrointestinal	ADJ
admet-1474	245	40	tract	tract	NOUN
admet-1474	245	41	where	where	SCONJ
admet-1474	245	42	absorption	absorption	NOUN
admet-1474	245	43	of	of	ADP
admet-1474	245	44	levodopa	levodopa	NOUN
admet-1474	245	45	occurs	occur	VERB
admet-1474	245	46	.	.	PUNCT
admet-1474	246	1	the	the	DET
admet-1474	246	2	release	release	NOUN
admet-1474	246	3	of	of	ADP
admet-1474	246	4	levodopa	levodopa	NOUN
admet-1474	246	5	and	and	CCONJ
admet-1474	246	6	carbidopa	carbidopa	NOUN
admet-1474	246	7	was	be	AUX
admet-1474	246	8	found	find	VERB
admet-1474	246	9	to	to	PART
admet-1474	246	10	be	be	AUX
admet-1474	246	11	controlled	control	VERB
admet-1474	246	12	.	.	PUNCT
admet-1474	247	1	in	in	ADP
admet-1474	247	2	this	this	DET
admet-1474	247	3	medium	medium	NOUN
admet-1474	247	4	,	,	PUNCT
admet-1474	247	5	the	the	DET
admet-1474	247	6	maximum	maximum	ADJ
admet-1474	247	7	release	release	NOUN
admet-1474	247	8	of	of	ADP
admet-1474	247	9	levodopa	levodopa	NOUN
admet-1474	247	10	and	and	CCONJ
admet-1474	247	11	carbidopa	carbidopa	NOUN
admet-1474	247	12	from	from	ADP
admet-1474	247	13	f3	f3	PROPN
admet-1474	247	14	and	and	CCONJ
admet-1474	247	15	f4	f4	PROPN
admet-1474	247	16	occurred	occur	VERB
admet-1474	247	17	after	after	ADP
admet-1474	247	18	4	4	NUM
admet-1474	247	19	hr	hr	NOUN
admet-1474	247	20	and	and	CCONJ
admet-1474	247	21	8	8	NUM
admet-1474	247	22	hr	hr	NOUN
admet-1474	247	23	,	,	PUNCT
admet-1474	247	24	respectively	respectively	ADV
admet-1474	247	25	.	.	PUNCT
admet-1474	248	1	in	in	ADP
admet-1474	248	2	the	the	DET
admet-1474	248	3	current	current	ADJ
admet-1474	248	4	study	study	NOUN
admet-1474	248	5	,	,	PUNCT
admet-1474	248	6	only	only	ADV
admet-1474	248	7	the	the	DET
admet-1474	248	8	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	248	9	parameters	parameter	NOUN
admet-1474	248	10	of	of	ADP
admet-1474	248	11	levodopa	levodopa	NOUN
admet-1474	248	12	were	be	AUX
admet-1474	248	13	considered	consider	VERB
admet-1474	248	14	;	;	PUNCT
admet-1474	248	15	as	as	SCONJ
admet-1474	248	16	seen	see	VERB
admet-1474	248	17	in	in	ADP
admet-1474	248	18	other	other	ADJ
admet-1474	248	19	studies	study	NOUN
admet-1474	248	20	[	[	X
admet-1474	248	21	50,51	50,51	NOUN
admet-1474	248	22	]	]	PUNCT
admet-1474	248	23	.	.	PUNCT
admet-1474	249	1	findings	finding	NOUN
admet-1474	249	2	from	from	ADP
admet-1474	249	3	the	the	DET
admet-1474	249	4	concentration	concentration	NOUN
admet-1474	249	5	-	-	PUNCT
admet-1474	249	6	time	time	NOUN
admet-1474	249	7	plots	plot	NOUN
admet-1474	249	8	of	of	ADP
admet-1474	249	9	levodopa	levodopa	NOUN
admet-1474	249	10	showed	show	VERB
admet-1474	249	11	that	that	SCONJ
admet-1474	249	12	higher	high	ADJ
admet-1474	249	13	peak	peak	NOUN
admet-1474	249	14	levodopa	levodopa	NOUN
admet-1474	249	15	plasma	plasma	NOUN
admet-1474	249	16	concentrations	concentration	NOUN
admet-1474	249	17	(	(	PUNCT
admet-1474	249	18	cmax	cmax	NOUN
admet-1474	249	19	)	)	PUNCT
admet-1474	249	20	were	be	AUX
admet-1474	249	21	achieved	achieve	VERB
admet-1474	249	22	with	with	ADP
admet-1474	249	23	f3	f3	PROPN
admet-1474	249	24	and	and	CCONJ
admet-1474	249	25	f4	f4	NOUN
admet-1474	249	26	compared	compare	VERB
admet-1474	249	27	to	to	ADP
admet-1474	249	28	other	other	ADJ
admet-1474	249	29	formulations	formulation	NOUN
admet-1474	249	30	.	.	PUNCT
admet-1474	250	1	previous	previous	ADJ
admet-1474	250	2	studies	study	NOUN
admet-1474	250	3	showed	show	VERB
admet-1474	250	4	similar	similar	ADJ
admet-1474	250	5	data	datum	NOUN
admet-1474	250	6	for	for	ADP
admet-1474	250	7	carvedilol	carvedilol	NOUN
admet-1474	250	8	and	and	CCONJ
admet-1474	250	9	anthracyanins	anthracyanin	NOUN
admet-1474	250	10	when	when	SCONJ
admet-1474	250	11	chitosan	chitosan	NOUN
admet-1474	250	12	-	-	PUNCT
admet-1474	250	13	pectin	pectin	NOUN
admet-1474	250	14	complexes	complex	NOUN
admet-1474	250	15	were	be	AUX
admet-1474	250	16	used	use	VERB
admet-1474	250	17	[	[	PUNCT
admet-1474	250	18	48,49	48,49	X
admet-1474	250	19	]	]	PUNCT
admet-1474	250	20	.	.	PUNCT
admet-1474	251	1	levels	level	NOUN
admet-1474	251	2	of	of	ADP
admet-1474	251	3	levodopa	levodopa	NOUN
admet-1474	251	4	in	in	ADP
admet-1474	251	5	plasma	plasma	NOUN
admet-1474	251	6	have	have	AUX
admet-1474	251	7	been	be	AUX
admet-1474	251	8	shown	show	VERB
admet-1474	251	9	to	to	PART
admet-1474	251	10	be	be	AUX
admet-1474	251	11	directly	directly	ADV
admet-1474	251	12	correlated	correlate	VERB
admet-1474	251	13	with	with	ADP
admet-1474	251	14	the	the	DET
admet-1474	251	15	amount	amount	NOUN
admet-1474	251	16	reaching	reach	VERB
admet-1474	251	17	the	the	DET
admet-1474	251	18	brain	brain	NOUN
admet-1474	252	1	[	[	X
admet-1474	252	2	52	52	NUM
admet-1474	252	3	]	]	PUNCT
admet-1474	252	4	;	;	PUNCT
admet-1474	252	5	hence	hence	ADV
admet-1474	252	6	a	a	DET
admet-1474	252	7	higher	high	ADJ
admet-1474	252	8	cmax	cmax	NOUN
admet-1474	252	9	may	may	AUX
admet-1474	252	10	result	result	VERB
admet-1474	252	11	in	in	ADP
admet-1474	252	12	an	an	DET
admet-1474	252	13	increase	increase	NOUN
admet-1474	252	14	in	in	ADP
admet-1474	252	15	the	the	DET
admet-1474	252	16	levels	level	NOUN
admet-1474	252	17	of	of	ADP
admet-1474	252	18	levodopa	levodopa	NOUN
admet-1474	252	19	in	in	ADP
admet-1474	252	20	the	the	DET
admet-1474	252	21	brain	brain	NOUN
admet-1474	252	22	.	.	PUNCT
admet-1474	253	1	this	this	PRON
admet-1474	253	2	may	may	AUX
admet-1474	253	3	be	be	AUX
admet-1474	253	4	advantageous	advantageous	ADJ
admet-1474	253	5	in	in	ADP
admet-1474	253	6	the	the	DET
admet-1474	253	7	management	management	NOUN
admet-1474	253	8	of	of	ADP
admet-1474	253	9	pd	pd	PROPN
admet-1474	253	10	.	.	PROPN
admet-1474	254	1	in	in	ADP
admet-1474	254	2	this	this	DET
admet-1474	254	3	study	study	NOUN
admet-1474	254	4	,	,	PUNCT
admet-1474	254	5	cmax	cmax	NOUN
admet-1474	254	6	for	for	ADP
admet-1474	254	7	f3	f3	PROPN
admet-1474	254	8	and	and	CCONJ
admet-1474	254	9	f4	f4	PROPN
admet-1474	254	10	were	be	AUX
admet-1474	254	11	reached	reach	VERB
admet-1474	254	12	after	after	ADP
admet-1474	254	13	4.0	4.0	NUM
admet-1474	254	14	(	(	PUNCT
admet-1474	254	15	±	±	NUM
admet-1474	254	16	0.00	0.00	NUM
admet-1474	254	17	)	)	PUNCT
admet-1474	254	18	hr	hr	NOUN
admet-1474	254	19	and	and	CCONJ
admet-1474	254	20	4.4	4.4	NUM
admet-1474	254	21	(	(	PUNCT
admet-1474	254	22	±	±	NOUN
admet-1474	254	23	2.19	2.19	NUM
admet-1474	254	24	)	)	PUNCT
admet-1474	254	25	hr	hr	NOUN
admet-1474	254	26	,	,	PUNCT
admet-1474	254	27	respectively	respectively	ADV
admet-1474	254	28	.	.	PUNCT
admet-1474	255	1	cmax	cmax	NOUN
admet-1474	255	2	for	for	ADP
admet-1474	255	3	sinemet	sinemet	NOUN
admet-1474	255	4	and	and	CCONJ
admet-1474	255	5	the	the	DET
admet-1474	255	6	levodopa	levodopa	NOUN
admet-1474	255	7	/	/	SYM
admet-1474	255	8	carbidopa	carbidopa	NOUN
admet-1474	255	9	powder	powder	NOUN
admet-1474	255	10	were	be	AUX
admet-1474	255	11	reached	reach	VERB
admet-1474	255	12	after	after	ADP
admet-1474	255	13	0.9	0.9	NUM
admet-1474	255	14	(	(	PUNCT
admet-1474	255	15	±	±	NOUN
admet-1474	255	16	0.22	0.22	NUM
admet-1474	255	17	)	)	PUNCT
admet-1474	255	18	hr	hr	NOUN
admet-1474	255	19	and	and	CCONJ
admet-1474	255	20	0.4	0.4	NUM
admet-1474	255	21	(	(	PUNCT
admet-1474	255	22	±	±	NOUN
admet-1474	255	23	0.34	0.34	NUM
admet-1474	255	24	)	)	PUNCT
admet-1474	255	25	hr	hr	NOUN
admet-1474	255	26	,	,	PUNCT
admet-1474	255	27	admet	admet	PROPN
admet-1474	255	28	&	&	CCONJ
admet-1474	255	29	dmpk	dmpk	PROPN
admet-1474	255	30	11(1	11(1	NUM
admet-1474	255	31	)	)	PUNCT
admet-1474	255	32	(	(	PUNCT
admet-1474	255	33	2023	2023	NUM
admet-1474	255	34	)	)	PUNCT
admet-1474	255	35	97	97	NUM
admet-1474	255	36	-	-	SYM
admet-1474	255	37	115	115	NUM
admet-1474	255	38	evaluation	evaluation	NOUN
admet-1474	255	39	of	of	ADP
admet-1474	255	40	re	re	ADJ
admet-1474	255	41	-	-	ADJ
admet-1474	255	42	formulated	formulate	VERB
admet-1474	255	43	levodopa	levodopa	NOUN
admet-1474	255	44	and	and	CCONJ
admet-1474	255	45	carbidopa	carbidopa	NOUN
admet-1474	255	46	doi	doi	NOUN
admet-1474	255	47	:	:	PUNCT
admet-1474	255	48	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	NOUN
admet-1474	255	49	111	111	NUM
admet-1474	255	50	respectively	respectively	ADV
admet-1474	255	51	.	.	PUNCT
admet-1474	256	1	thus	thus	ADV
admet-1474	256	2	,	,	PUNCT
admet-1474	256	3	the	the	DET
admet-1474	256	4	matrix	matrix	NOUN
admet-1474	256	5	formulations	formulation	NOUN
admet-1474	256	6	demonstrated	demonstrate	VERB
admet-1474	256	7	a	a	DET
admet-1474	256	8	prolonged	prolonged	ADJ
admet-1474	256	9	release	release	NOUN
admet-1474	256	10	of	of	ADP
admet-1474	256	11	levodopa	levodopa	NOUN
admet-1474	256	12	.	.	PUNCT
admet-1474	257	1	such	such	ADJ
admet-1474	257	2	prolonged	prolonged	ADJ
admet-1474	257	3	-	-	PUNCT
admet-1474	257	4	release	release	NOUN
admet-1474	257	5	formulations	formulation	NOUN
admet-1474	257	6	of	of	ADP
admet-1474	257	7	levodopa	levodopa	NOUN
admet-1474	257	8	/	/	SYM
admet-1474	257	9	carbidopa	carbidopa	NOUN
admet-1474	257	10	are	be	AUX
admet-1474	257	11	known	know	VERB
admet-1474	257	12	to	to	PART
admet-1474	257	13	reduce	reduce	VERB
admet-1474	257	14	the	the	DET
admet-1474	257	15	frequency	frequency	NOUN
admet-1474	257	16	of	of	ADP
admet-1474	257	17	dosing	dose	VERB
admet-1474	257	18	and	and	CCONJ
admet-1474	257	19	enhance	enhance	VERB
admet-1474	257	20	patient	patient	ADJ
admet-1474	257	21	compliance	compliance	NOUN
admet-1474	258	1	[	[	X
admet-1474	258	2	53,54	53,54	NUM
admet-1474	258	3	]	]	X
admet-1474	258	4	.	.	PUNCT
admet-1474	259	1	the	the	DET
admet-1474	259	2	auc	auc	NOUN
admet-1474	259	3	of	of	ADP
admet-1474	259	4	the	the	DET
admet-1474	259	5	various	various	ADJ
admet-1474	259	6	formulations	formulation	NOUN
admet-1474	259	7	showed	show	VERB
admet-1474	259	8	that	that	SCONJ
admet-1474	259	9	f3	f3	PROPN
admet-1474	259	10	and	and	CCONJ
admet-1474	259	11	f4	f4	NOUN
admet-1474	259	12	were	be	AUX
admet-1474	259	13	greater	great	ADJ
admet-1474	259	14	,	,	PUNCT
admet-1474	259	15	about	about	ADV
admet-1474	259	16	twice	twice	DET
admet-1474	259	17	that	that	PRON
admet-1474	259	18	of	of	ADP
admet-1474	259	19	the	the	DET
admet-1474	259	20	auc	auc	NOUN
admet-1474	259	21	of	of	ADP
admet-1474	259	22	sinemet	sinemet	PROPN
admet-1474	259	23	®	®	PROPN
admet-1474	259	24	cr	cr	PROPN
admet-1474	259	25	(	(	PUNCT
admet-1474	259	26	table	table	NOUN
admet-1474	259	27	5	5	NUM
admet-1474	259	28	)	)	PUNCT
admet-1474	259	29	.	.	PUNCT
admet-1474	260	1	aucs	aucs	NOUN
admet-1474	260	2	from	from	ADP
admet-1474	260	3	concentration	concentration	NOUN
admet-1474	260	4	-	-	PUNCT
admet-1474	260	5	time	time	NOUN
admet-1474	260	6	curves	curve	NOUN
admet-1474	260	7	reflect	reflect	VERB
admet-1474	260	8	total	total	ADJ
admet-1474	260	9	drug	drug	NOUN
admet-1474	260	10	exposure	exposure	NOUN
admet-1474	260	11	after	after	ADP
admet-1474	260	12	drug	drug	NOUN
admet-1474	260	13	administration	administration	NOUN
admet-1474	260	14	[	[	X
admet-1474	260	15	55	55	NUM
admet-1474	260	16	]	]	PUNCT
admet-1474	260	17	.	.	PUNCT
admet-1474	261	1	the	the	DET
admet-1474	261	2	high	high	ADJ
admet-1474	261	3	auc	auc	NOUN
admet-1474	261	4	values	value	NOUN
admet-1474	261	5	of	of	ADP
admet-1474	261	6	f3	f3	PROPN
admet-1474	261	7	and	and	CCONJ
admet-1474	261	8	f4	f4	PROPN
admet-1474	261	9	could	could	AUX
admet-1474	261	10	be	be	AUX
admet-1474	261	11	attributed	attribute	VERB
admet-1474	261	12	to	to	ADP
admet-1474	261	13	the	the	DET
admet-1474	261	14	chitosan	chitosan	NOUN
admet-1474	261	15	's	's	PART
admet-1474	261	16	outstanding	outstanding	ADJ
admet-1474	261	17	mucoadhesive	mucoadhesive	ADJ
admet-1474	261	18	properties	property	NOUN
admet-1474	261	19	conferred	confer	VERB
admet-1474	261	20	on	on	ADP
admet-1474	261	21	the	the	DET
admet-1474	261	22	matrix	matrix	NOUN
admet-1474	261	23	.	.	PUNCT
admet-1474	262	1	chitosan	chitosan	PROPN
admet-1474	262	2	,	,	PUNCT
admet-1474	262	3	a	a	DET
admet-1474	262	4	mucoadhesive	mucoadhesive	ADJ
admet-1474	262	5	polymer	polymer	NOUN
admet-1474	262	6	,	,	PUNCT
admet-1474	262	7	is	be	AUX
admet-1474	262	8	positively	positively	ADV
admet-1474	262	9	charged	charge	VERB
admet-1474	262	10	and	and	CCONJ
admet-1474	262	11	readily	readily	ADV
admet-1474	262	12	interacts	interact	VERB
admet-1474	262	13	with	with	ADP
admet-1474	262	14	mucous	mucous	ADJ
admet-1474	262	15	membranes	membrane	NOUN
admet-1474	262	16	of	of	ADP
admet-1474	262	17	the	the	DET
admet-1474	262	18	gastrointestinal	gastrointestinal	ADJ
admet-1474	262	19	tract	tract	NOUN
admet-1474	262	20	(	(	PUNCT
admet-1474	262	21	negatively	negatively	ADV
admet-1474	262	22	charged	charge	VERB
admet-1474	262	23	)	)	PUNCT
admet-1474	262	24	,	,	PUNCT
admet-1474	262	25	thereby	thereby	ADV
admet-1474	262	26	increasing	increase	VERB
admet-1474	262	27	adhesion	adhesion	NOUN
admet-1474	262	28	and	and	CCONJ
admet-1474	262	29	thus	thus	ADV
admet-1474	262	30	improving	improve	VERB
admet-1474	262	31	contact	contact	NOUN
admet-1474	262	32	time	time	NOUN
admet-1474	262	33	for	for	ADP
admet-1474	262	34	drug	drug	NOUN
admet-1474	262	35	absorption	absorption	NOUN
admet-1474	262	36	[	[	X
admet-1474	262	37	56	56	NUM
admet-1474	262	38	]	]	PUNCT
admet-1474	262	39	.	.	PUNCT
admet-1474	263	1	furthermore	furthermore	ADV
admet-1474	263	2	,	,	PUNCT
admet-1474	263	3	chitosan	chitosan	PROPN
admet-1474	263	4	has	have	AUX
admet-1474	263	5	been	be	AUX
admet-1474	263	6	shown	show	VERB
admet-1474	263	7	to	to	PART
admet-1474	263	8	have	have	VERB
admet-1474	263	9	permeation	permeation	NOUN
admet-1474	263	10	-	-	PUNCT
admet-1474	263	11	enhancing	enhance	VERB
admet-1474	263	12	properties	property	NOUN
admet-1474	263	13	[	[	X
admet-1474	263	14	57,58	57,58	NUM
admet-1474	263	15	]	]	PUNCT
admet-1474	263	16	.	.	PUNCT
admet-1474	264	1	since	since	SCONJ
admet-1474	264	2	auc	auc	NOUN
admet-1474	264	3	is	be	AUX
admet-1474	264	4	a	a	DET
admet-1474	264	5	reliable	reliable	ADJ
admet-1474	264	6	measure	measure	NOUN
admet-1474	264	7	of	of	ADP
admet-1474	264	8	the	the	DET
admet-1474	264	9	bioavailability	bioavailability	NOUN
admet-1474	264	10	of	of	ADP
admet-1474	264	11	a	a	DET
admet-1474	264	12	drug	drug	NOUN
admet-1474	264	13	,	,	PUNCT
admet-1474	264	14	it	it	PRON
admet-1474	264	15	can	can	AUX
admet-1474	264	16	be	be	AUX
admet-1474	264	17	inferred	infer	VERB
admet-1474	264	18	that	that	SCONJ
admet-1474	264	19	the	the	DET
admet-1474	264	20	chitosan	chitosan	NOUN
admet-1474	264	21	-	-	PUNCT
admet-1474	264	22	pectin	pectin	NOUN
admet-1474	264	23	-	-	PUNCT
admet-1474	264	24	based	base	VERB
admet-1474	264	25	matrix	matrix	NOUN
admet-1474	264	26	of	of	ADP
admet-1474	264	27	levodopa	levodopa	NOUN
admet-1474	264	28	/	/	SYM
admet-1474	264	29	carbidopa	carbidopa	NOUN
admet-1474	264	30	had	have	VERB
admet-1474	264	31	greater	great	ADJ
admet-1474	264	32	bioavailability	bioavailability	NOUN
admet-1474	264	33	than	than	ADP
admet-1474	264	34	sinemet	sinemet	PROPN
admet-1474	264	35	®	®	PROPN
admet-1474	264	36	cr	cr	PROPN
admet-1474	264	37	(	(	PUNCT
admet-1474	264	38	conventional	conventional	ADJ
admet-1474	264	39	controlled	control	VERB
admet-1474	264	40	-	-	PUNCT
admet-1474	264	41	release	release	NOUN
admet-1474	264	42	product	product	NOUN
admet-1474	264	43	on	on	ADP
admet-1474	264	44	the	the	DET
admet-1474	264	45	market	market	NOUN
admet-1474	264	46	)	)	PUNCT
admet-1474	264	47	.	.	PUNCT
admet-1474	265	1	furthermore	furthermore	ADV
admet-1474	265	2	,	,	PUNCT
admet-1474	265	3	the	the	DET
admet-1474	265	4	current	current	ADJ
admet-1474	265	5	study	study	NOUN
admet-1474	265	6	showed	show	VERB
admet-1474	265	7	that	that	SCONJ
admet-1474	265	8	half	half	ADJ
admet-1474	265	9	-	-	PUNCT
admet-1474	265	10	life	life	NOUN
admet-1474	265	11	was	be	AUX
admet-1474	265	12	longest	long	ADJ
admet-1474	265	13	for	for	ADP
admet-1474	265	14	f4	f4	PROPN
admet-1474	265	15	(	(	PUNCT
admet-1474	265	16	8.84	8.84	NUM
admet-1474	265	17	±	±	NUM
admet-1474	265	18	2.95	2.95	NUM
admet-1474	265	19	hr	hr	NOUN
admet-1474	265	20	)	)	PUNCT
admet-1474	265	21	,	,	PUNCT
admet-1474	265	22	followed	follow	VERB
admet-1474	265	23	by	by	ADP
admet-1474	265	24	f3	f3	PROPN
admet-1474	265	25	(	(	PUNCT
admet-1474	265	26	8.33	8.33	NUM
admet-1474	265	27	±	±	NUM
admet-1474	265	28	0.01	0.01	NUM
admet-1474	265	29	hr	hr	NOUN
admet-1474	265	30	)	)	PUNCT
admet-1474	265	31	and	and	CCONJ
admet-1474	265	32	sinemet	sinemet	PROPN
admet-1474	265	33	®	®	PROPN
admet-1474	265	34	cr	cr	PROPN
admet-1474	265	35	(	(	PUNCT
admet-1474	265	36	5.34	5.34	NUM
admet-1474	265	37	±	±	NUM
admet-1474	265	38	0.95	0.95	NUM
admet-1474	265	39	hr	hr	NOUN
admet-1474	265	40	)	)	PUNCT
admet-1474	265	41	.	.	PUNCT
admet-1474	266	1	half	half	ADJ
admet-1474	266	2	-	-	PUNCT
admet-1474	266	3	life	life	NOUN
admet-1474	266	4	has	have	AUX
admet-1474	266	5	been	be	AUX
admet-1474	266	6	shown	show	VERB
admet-1474	266	7	to	to	PART
admet-1474	266	8	play	play	VERB
admet-1474	266	9	a	a	DET
admet-1474	266	10	key	key	ADJ
admet-1474	266	11	role	role	NOUN
admet-1474	266	12	in	in	ADP
admet-1474	266	13	determining	determine	VERB
admet-1474	266	14	the	the	DET
admet-1474	266	15	duration	duration	NOUN
admet-1474	266	16	of	of	ADP
admet-1474	266	17	action	action	NOUN
admet-1474	266	18	of	of	ADP
admet-1474	266	19	a	a	DET
admet-1474	266	20	drug	drug	NOUN
admet-1474	266	21	[	[	X
admet-1474	266	22	55	55	NUM
admet-1474	266	23	]	]	PUNCT
admet-1474	266	24	.	.	PUNCT
admet-1474	267	1	data	datum	NOUN
admet-1474	267	2	from	from	ADP
admet-1474	267	3	this	this	DET
admet-1474	267	4	study	study	NOUN
admet-1474	267	5	suggests	suggest	VERB
admet-1474	267	6	that	that	SCONJ
admet-1474	267	7	it	it	PRON
admet-1474	267	8	takes	take	VERB
admet-1474	267	9	a	a	DET
admet-1474	267	10	relatively	relatively	ADV
admet-1474	267	11	long	long	ADJ
admet-1474	267	12	time	time	NOUN
admet-1474	267	13	for	for	ADP
admet-1474	267	14	levodopa	levodopa	NOUN
admet-1474	267	15	within	within	ADP
admet-1474	267	16	the	the	DET
admet-1474	267	17	chitosan	chitosan	NOUN
admet-1474	267	18	-	-	PUNCT
admet-1474	267	19	pectin	pectin	NOUN
admet-1474	267	20	-	-	PUNCT
admet-1474	267	21	based	base	VERB
admet-1474	267	22	matrix	matrix	NOUN
admet-1474	267	23	to	to	PART
admet-1474	267	24	be	be	AUX
admet-1474	267	25	cleared	clear	VERB
admet-1474	267	26	from	from	ADP
admet-1474	267	27	plasma	plasma	NOUN
admet-1474	267	28	.	.	PUNCT
admet-1474	268	1	this	this	DET
admet-1474	268	2	property	property	NOUN
admet-1474	268	3	may	may	AUX
admet-1474	268	4	be	be	AUX
admet-1474	268	5	of	of	ADP
admet-1474	268	6	great	great	ADJ
admet-1474	268	7	benefit	benefit	NOUN
admet-1474	268	8	in	in	ADP
admet-1474	268	9	preventing	prevent	VERB
admet-1474	268	10	the	the	DET
admet-1474	268	11	“	"	PUNCT
admet-1474	268	12	on	on	ADP
admet-1474	268	13	”	"	PUNCT
admet-1474	268	14	and	and	CCONJ
admet-1474	268	15	“	"	PUNCT
admet-1474	268	16	off	off	ADJ
admet-1474	268	17	”	"	PUNCT
admet-1474	268	18	phenomenon	phenomenon	NOUN
admet-1474	268	19	observed	observe	VERB
admet-1474	268	20	with	with	ADP
admet-1474	268	21	the	the	DET
admet-1474	268	22	use	use	NOUN
admet-1474	268	23	of	of	ADP
admet-1474	268	24	conventional	conventional	ADJ
admet-1474	268	25	levodopa	levodopa	NOUN
admet-1474	268	26	/	/	SYM
admet-1474	268	27	carbidopa	carbidopa	NOUN
admet-1474	268	28	formulations	formulation	NOUN
admet-1474	268	29	.	.	PUNCT
admet-1474	269	1	chitosan	chitosan	NOUN
admet-1474	269	2	-	-	PUNCT
admet-1474	269	3	pectin	pectin	NOUN
admet-1474	269	4	-	-	PUNCT
admet-1474	269	5	based	base	VERB
admet-1474	269	6	matrix	matrix	NOUN
admet-1474	269	7	provides	provide	VERB
admet-1474	269	8	a	a	DET
admet-1474	269	9	complex	complex	NOUN
admet-1474	269	10	that	that	SCONJ
admet-1474	269	11	controls	control	VERB
admet-1474	269	12	and	and	CCONJ
admet-1474	269	13	delays	delay	VERB
admet-1474	269	14	the	the	DET
admet-1474	269	15	release	release	NOUN
admet-1474	269	16	of	of	ADP
admet-1474	269	17	drugs	drug	NOUN
admet-1474	269	18	into	into	ADP
admet-1474	269	19	plasma	plasma	NOUN
admet-1474	269	20	[	[	X
admet-1474	269	21	59–62	59–62	NUM
admet-1474	269	22	]	]	PUNCT
admet-1474	269	23	.	.	PUNCT
admet-1474	270	1	conclusions	conclusion	NOUN
admet-1474	270	2	the	the	DET
admet-1474	270	3	oral	oral	ADJ
admet-1474	270	4	multiparticulate	multiparticulate	ADJ
admet-1474	270	5	matrix	matrix	NOUN
admet-1474	270	6	of	of	ADP
admet-1474	270	7	levodopa	levodopa	NOUN
admet-1474	270	8	/	/	SYM
admet-1474	270	9	carbidopa	carbidopa	NOUN
admet-1474	270	10	exhibited	exhibit	VERB
admet-1474	270	11	modest	modest	ADJ
admet-1474	270	12	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	270	13	characteristics	characteristic	NOUN
admet-1474	270	14	compared	compare	VERB
admet-1474	270	15	to	to	ADP
admet-1474	270	16	the	the	DET
admet-1474	270	17	conventional	conventional	ADJ
admet-1474	270	18	controlled	control	VERB
admet-1474	270	19	release	release	NOUN
admet-1474	270	20	formulation	formulation	NOUN
admet-1474	270	21	(	(	PUNCT
admet-1474	270	22	sinemet	sinemet	PROPN
admet-1474	270	23	®	®	NOUN
admet-1474	270	24	cr	cr	X
admet-1474	270	25	)	)	PUNCT
admet-1474	270	26	and	and	CCONJ
admet-1474	270	27	levodopa	levodopa	NOUN
admet-1474	270	28	/	/	SYM
admet-1474	270	29	carbidopa	carbidopa	NOUN
admet-1474	270	30	powder	powder	NOUN
admet-1474	270	31	.	.	PUNCT
admet-1474	271	1	the	the	DET
admet-1474	271	2	mucoadhesive	mucoadhesive	ADJ
admet-1474	271	3	nature	nature	NOUN
admet-1474	271	4	of	of	ADP
admet-1474	271	5	the	the	DET
admet-1474	271	6	matrix	matrix	NOUN
admet-1474	271	7	and	and	CCONJ
admet-1474	271	8	sustained	sustained	ADJ
admet-1474	271	9	delivery	delivery	NOUN
admet-1474	271	10	of	of	ADP
admet-1474	271	11	levodopa	levodopa	NOUN
admet-1474	271	12	can	can	AUX
admet-1474	271	13	be	be	AUX
admet-1474	271	14	employed	employ	VERB
admet-1474	271	15	in	in	ADP
admet-1474	271	16	overcoming	overcome	VERB
admet-1474	271	17	the	the	DET
admet-1474	271	18	irregular	irregular	ADJ
admet-1474	271	19	gastric	gastric	ADJ
admet-1474	271	20	emptying	empty	VERB
admet-1474	271	21	and	and	CCONJ
admet-1474	271	22	motor	motor	NOUN
admet-1474	271	23	fluctuations	fluctuation	NOUN
admet-1474	271	24	(	(	PUNCT
admet-1474	271	25	‘	'	PUNCT
admet-1474	271	26	on	on	ADP
admet-1474	271	27	’	'	PUNCT
admet-1474	271	28	and	and	CCONJ
admet-1474	271	29	‘	'	PUNCT
admet-1474	271	30	off	off	ADJ
admet-1474	271	31	’	'	PUNCT
admet-1474	271	32	phenomenon	phenomenon	NOUN
admet-1474	271	33	)	)	PUNCT
admet-1474	271	34	associated	associate	VERB
admet-1474	271	35	with	with	ADP
admet-1474	271	36	oral	oral	ADJ
admet-1474	271	37	administration	administration	NOUN
admet-1474	271	38	of	of	ADP
admet-1474	271	39	levodopa	levodopa	NOUN
admet-1474	271	40	.	.	PUNCT
admet-1474	272	1	future	future	ADJ
admet-1474	272	2	studies	study	NOUN
admet-1474	272	3	should	should	AUX
admet-1474	272	4	be	be	AUX
admet-1474	272	5	conducted	conduct	VERB
admet-1474	272	6	to	to	PART
admet-1474	272	7	evaluate	evaluate	VERB
admet-1474	272	8	the	the	DET
admet-1474	272	9	biodistribution	biodistribution	NOUN
admet-1474	272	10	and	and	CCONJ
admet-1474	272	11	efficacy	efficacy	NOUN
admet-1474	272	12	of	of	ADP
admet-1474	272	13	this	this	DET
admet-1474	272	14	new	new	ADJ
admet-1474	272	15	formulation	formulation	NOUN
admet-1474	272	16	.	.	PUNCT
admet-1474	273	1	acknowledgements	acknowledgement	NOUN
admet-1474	273	2	:	:	PUNCT
admet-1474	273	3	the	the	DET
admet-1474	273	4	authors	author	NOUN
admet-1474	273	5	are	be	AUX
admet-1474	273	6	thankful	thankful	ADJ
admet-1474	273	7	to	to	ADP
admet-1474	273	8	mr	mr	PROPN
admet-1474	273	9	.	.	PROPN
admet-1474	273	10	samuel	samuel	PROPN
admet-1474	273	11	otinkorang	otinkorang	PROPN
admet-1474	273	12	of	of	ADP
admet-1474	273	13	the	the	DET
admet-1474	273	14	department	department	NOUN
admet-1474	273	15	of	of	ADP
admet-1474	273	16	pharmaceutics	pharmaceutic	NOUN
admet-1474	273	17	and	and	CCONJ
admet-1474	273	18	microbiology	microbiology	NOUN
admet-1474	273	19	,	,	PUNCT
admet-1474	273	20	school	school	NOUN
admet-1474	273	21	of	of	ADP
admet-1474	273	22	pharmacy	pharmacy	NOUN
admet-1474	273	23	,	,	PUNCT
admet-1474	273	24	university	university	NOUN
admet-1474	273	25	of	of	ADP
admet-1474	273	26	ghana	ghana	PROPN
admet-1474	273	27	.	.	PUNCT
admet-1474	274	1	conflict	conflict	NOUN
admet-1474	274	2	of	of	ADP
admet-1474	274	3	interest	interest	NOUN
admet-1474	274	4	:	:	PUNCT
admet-1474	274	5	the	the	DET
admet-1474	274	6	authors	author	NOUN
admet-1474	274	7	declare	declare	VERB
admet-1474	274	8	that	that	SCONJ
admet-1474	274	9	they	they	PRON
admet-1474	274	10	have	have	VERB
admet-1474	274	11	no	no	DET
admet-1474	274	12	conflict	conflict	NOUN
admet-1474	274	13	of	of	ADP
admet-1474	274	14	interest	interest	NOUN
admet-1474	274	15	.	.	PUNCT
admet-1474	275	1	references	reference	NOUN
admet-1474	275	2	[	[	X
admet-1474	275	3	1	1	X
admet-1474	275	4	]	]	X
admet-1474	275	5	o.b	o.b	PROPN
admet-1474	275	6	.	.	PROPN
admet-1474	275	7	tysnes	tysnes	PROPN
admet-1474	275	8	,	,	PUNCT
admet-1474	275	9	a.	a.	PROPN
admet-1474	275	10	storstein	storstein	PROPN
admet-1474	275	11	.	.	PUNCT
admet-1474	276	1	epidemiology	epidemiology	NOUN
admet-1474	276	2	of	of	ADP
admet-1474	276	3	parkinson	parkinson	NOUN
admet-1474	276	4	’s	’s	PART
admet-1474	276	5	disease	disease	NOUN
admet-1474	276	6	.	.	PUNCT
admet-1474	277	1	journal	journal	PROPN
admet-1474	277	2	of	of	ADP
admet-1474	277	3	neural	neural	ADJ
admet-1474	277	4	transmission	transmission	NOUN
admet-1474	277	5	124	124	NUM
admet-1474	277	6	(	(	PUNCT
admet-1474	277	7	2017	2017	NUM
admet-1474	277	8	)	)	PUNCT
admet-1474	277	9	901–905	901–905	NUM
admet-1474	277	10	.	.	PUNCT
admet-1474	278	1	https://doi.org/10.1007/s00702-017-1686-y	https://doi.org/10.1007/s00702-017-1686-y	NOUN
admet-1474	278	2	.	.	PUNCT
admet-1474	279	1	[	[	X
admet-1474	279	2	2	2	NUM
admet-1474	279	3	]	]	PUNCT
admet-1474	279	4	a.	a.	NOUN
admet-1474	279	5	kouli	kouli	PROPN
admet-1474	279	6	,	,	PUNCT
admet-1474	279	7	k.m	k.m	PROPN
admet-1474	279	8	.	.	PROPN
admet-1474	279	9	torsney	torsney	PROPN
admet-1474	279	10	,	,	PUNCT
admet-1474	279	11	w.-l	w.-l	PROPN
admet-1474	279	12	.	.	PUNCT
admet-1474	280	1	kuan	kuan	PROPN
admet-1474	280	2	.	.	PUNCT
admet-1474	280	3	parkinson	parkinson	PROPN
admet-1474	280	4	’s	’s	PART
admet-1474	280	5	disease	disease	NOUN
admet-1474	280	6	:	:	PUNCT
admet-1474	280	7	etiology	etiology	NOUN
admet-1474	280	8	,	,	PUNCT
admet-1474	280	9	neuropathology	neuropathology	NOUN
admet-1474	280	10	,	,	PUNCT
admet-1474	280	11	and	and	CCONJ
admet-1474	280	12	pathogenesis	pathogenesis	NOUN
admet-1474	280	13	.	.	PUNCT
admet-1474	281	1	in	in	ADP
admet-1474	281	2	:	:	PUNCT
admet-1474	281	3	park	park	NOUN
admet-1474	281	4	.	.	PUNCT
admet-1474	282	1	dis	dis	PROPN
admet-1474	282	2	.	.	PUNCT
admet-1474	283	1	pathog	pathog	PROPN
admet-1474	283	2	.	.	PUNCT
admet-1474	284	1	clin	clin	PROPN
admet-1474	284	2	.	.	PUNCT
admet-1474	285	1	asp	asp	PROPN
admet-1474	285	2	.	.	PROPN
admet-1474	285	3	,	,	PUNCT
admet-1474	285	4	2018	2018	NUM
admet-1474	285	5	:	:	PUNCT
admet-1474	286	1	pp	pp	ADP
admet-1474	286	2	.	.	PUNCT
admet-1474	287	1	3–26	3–26	NUM
admet-1474	287	2	.	.	PUNCT
admet-1474	288	1	https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1	https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1	PROPN
admet-1474	288	2	.	.	PUNCT
admet-1474	289	1	[	[	X
admet-1474	289	2	3	3	X
admet-1474	289	3	]	]	X
admet-1474	289	4	e.	e.	PROPN
admet-1474	289	5	ray	ray	PROPN
admet-1474	289	6	dorsey	dorsey	PROPN
admet-1474	289	7	,	,	PUNCT
admet-1474	289	8	a.	a.	PROPN
admet-1474	289	9	elbaz	elbaz	PROPN
admet-1474	289	10	,	,	PUNCT
admet-1474	289	11	e.	e.	PROPN
admet-1474	289	12	nichols	nichols	PROPN
admet-1474	289	13	,	,	PUNCT
admet-1474	289	14	f.	f.	PROPN
admet-1474	289	15	abd	abd	PROPN
admet-1474	289	16	-	-	PUNCT
admet-1474	289	17	allah	allah	PROPN
admet-1474	289	18	,	,	PUNCT
admet-1474	289	19	a.	a.	PROPN
admet-1474	289	20	abdelalim	abdelalim	PROPN
admet-1474	289	21	,	,	PUNCT
admet-1474	289	22	et	et	PROPN
admet-1474	289	23	al	al	PROPN
admet-1474	289	24	.	.	PROPN
admet-1474	290	1	global	global	ADJ
admet-1474	290	2	,	,	PUNCT
admet-1474	290	3	regional	regional	ADJ
admet-1474	290	4	,	,	PUNCT
admet-1474	290	5	and	and	CCONJ
admet-1474	290	6	national	national	ADJ
admet-1474	290	7	burden	burden	NOUN
admet-1474	290	8	of	of	ADP
admet-1474	290	9	parkinson	parkinson	NOUN
admet-1474	290	10	’s	’s	PART
admet-1474	290	11	disease	disease	NOUN
admet-1474	290	12	,	,	PUNCT
admet-1474	290	13	1990–2016	1990–2016	NUM
admet-1474	290	14	:	:	PUNCT
admet-1474	290	15	a	a	DET
admet-1474	290	16	systematic	systematic	ADJ
admet-1474	290	17	analysis	analysis	NOUN
admet-1474	290	18	for	for	ADP
admet-1474	290	19	the	the	DET
admet-1474	290	20	global	global	ADJ
admet-1474	290	21	burden	burden	NOUN
admet-1474	290	22	of	of	ADP
admet-1474	290	23	disease	disease	NOUN
admet-1474	290	24	study	study	NOUN
admet-1474	290	25	2016	2016	NUM
admet-1474	290	26	.	.	PUNCT
admet-1474	291	1	the	the	DET
admet-1474	291	2	lancet	lancet	PROPN
admet-1474	291	3	neurology	neurology	NOUN
admet-1474	291	4	17	17	NUM
admet-1474	291	5	(	(	PUNCT
admet-1474	291	6	2018	2018	NUM
admet-1474	291	7	)	)	PUNCT
admet-1474	291	8	939–953	939–953	NUM
admet-1474	291	9	.	.	PUNCT
admet-1474	292	1	https://doi.org/10.1016/s14744422(18)30295-3	https://doi.org/10.1016/s14744422(18)30295-3	NOUN
admet-1474	292	2	.	.	PUNCT
admet-1474	293	1	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	294	1	https://doi.org/10.1007/s00702-017-1686-y	https://doi.org/10.1007/s00702-017-1686-y	PROPN
admet-1474	294	2	https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1	https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1	PROPN
admet-1474	294	3	https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1	https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1	PROPN
admet-1474	295	1	https://doi.org/10.1016/s1474-4422(18)30295-3	https://doi.org/10.1016/s1474-4422(18)30295-3	PROPN
admet-1474	295	2	https://doi.org/10.1016/s1474-4422(18)30295-3	https://doi.org/10.1016/s1474-4422(18)30295-3	PROPN
admet-1474	295	3	emelia	emelia	PROPN
admet-1474	295	4	priscilla	priscilla	PROPN
admet-1474	296	1	imbeah	imbeah	PROPN
admet-1474	296	2	et	et	PROPN
admet-1474	296	3	al	al	PROPN
admet-1474	296	4	.	.	PROPN
admet-1474	296	5	admet	admet	PROPN
admet-1474	296	6	&	&	CCONJ
admet-1474	296	7	dmpk	dmpk	PROPN
admet-1474	296	8	11(1	11(1	NUM
admet-1474	296	9	)	)	PUNCT
admet-1474	296	10	(	(	PUNCT
admet-1474	296	11	2023	2023	NUM
admet-1474	296	12	)	)	PUNCT
admet-1474	296	13	97	97	NUM
admet-1474	296	14	-	-	SYM
admet-1474	296	15	115	115	NUM
admet-1474	296	16	112	112	NUM
admet-1474	297	1	[	[	X
admet-1474	297	2	4	4	NUM
admet-1474	297	3	]	]	X
admet-1474	297	4	u.	u.	PROPN
admet-1474	297	5	williams	williams	PROPN
admet-1474	297	6	,	,	PUNCT
admet-1474	297	7	o.	o.	PROPN
admet-1474	297	8	bandmann	bandmann	PROPN
admet-1474	297	9	,	,	PUNCT
admet-1474	297	10	r.	r.	PROPN
admet-1474	297	11	walker	walker	PROPN
admet-1474	297	12	.	.	PUNCT
admet-1474	298	1	parkinson	parkinson	PROPN
admet-1474	298	2	’s	’s	PART
admet-1474	298	3	disease	disease	NOUN
admet-1474	298	4	in	in	ADP
admet-1474	298	5	sub	sub	ADJ
admet-1474	298	6	-	-	ADJ
admet-1474	298	7	saharan	saharan	ADJ
admet-1474	298	8	africa	africa	PROPN
admet-1474	298	9	:	:	PUNCT
admet-1474	298	10	a	a	DET
admet-1474	298	11	review	review	NOUN
admet-1474	298	12	of	of	ADP
admet-1474	298	13	epidemiology	epidemiology	NOUN
admet-1474	298	14	,	,	PUNCT
admet-1474	298	15	genetics	genetic	NOUN
admet-1474	298	16	and	and	CCONJ
admet-1474	298	17	access	access	NOUN
admet-1474	298	18	to	to	ADP
admet-1474	298	19	care	care	NOUN
admet-1474	298	20	.	.	PUNCT
admet-1474	299	1	journal	journal	PROPN
admet-1474	299	2	of	of	ADP
admet-1474	299	3	movement	movement	NOUN
admet-1474	299	4	disorders	disorder	NOUN
admet-1474	299	5	11	11	NUM
admet-1474	299	6	(	(	PUNCT
admet-1474	299	7	2018	2018	NUM
admet-1474	299	8	)	)	PUNCT
admet-1474	300	1	53–64	53–64	NUM
admet-1474	300	2	.	.	PUNCT
admet-1474	301	1	https://doi.org/10.14802/jmd.17028	https://doi.org/10.14802/jmd.17028	PROPN
admet-1474	301	2	.	.	PUNCT
admet-1474	302	1	[	[	X
admet-1474	302	2	5	5	X
admet-1474	302	3	]	]	PUNCT
admet-1474	302	4	s.	s.	PROPN
admet-1474	302	5	arisoy	arisoy	PROPN
admet-1474	302	6	,	,	PUNCT
admet-1474	302	7	o.	o.	NOUN
admet-1474	302	8	sayiner	sayiner	NOUN
admet-1474	302	9	,	,	PUNCT
admet-1474	302	10	t.	t.	PROPN
admet-1474	302	11	comoglu	comoglu	PROPN
admet-1474	302	12	,	,	PUNCT
admet-1474	302	13	d.	d.	PROPN
admet-1474	302	14	onal	onal	PROPN
admet-1474	302	15	,	,	PUNCT
admet-1474	302	16	o.	o.	PROPN
admet-1474	302	17	atalay	atalay	PROPN
admet-1474	302	18	,	,	PUNCT
admet-1474	302	19	b.	b.	PROPN
admet-1474	302	20	pehlivanoglu	pehlivanoglu	PROPN
admet-1474	302	21	.	.	PUNCT
admet-1474	303	1	in	in	ADP
admet-1474	303	2	vitro	vitro	X
admet-1474	303	3	and	and	CCONJ
admet-1474	303	4	in	in	ADP
admet-1474	303	5	vivo	vivo	ADJ
admet-1474	303	6	evaluation	evaluation	NOUN
admet-1474	303	7	of	of	ADP
admet-1474	303	8	levodopa	levodopa	NOUN
admet-1474	303	9	-	-	PUNCT
admet-1474	303	10	loaded	load	VERB
admet-1474	303	11	nanoparticles	nanoparticle	NOUN
admet-1474	303	12	for	for	ADP
admet-1474	303	13	nose	nose	NOUN
admet-1474	303	14	to	to	ADP
admet-1474	303	15	brain	brain	NOUN
admet-1474	303	16	delivery	delivery	NOUN
admet-1474	303	17	.	.	PUNCT
admet-1474	304	1	pharmaceutical	pharmaceutical	NOUN
admet-1474	304	2	development	development	NOUN
admet-1474	304	3	and	and	CCONJ
admet-1474	304	4	technology	technology	NOUN
admet-1474	304	5	25	25	NUM
admet-1474	304	6	(	(	PUNCT
admet-1474	304	7	2020	2020	NUM
admet-1474	304	8	)	)	PUNCT
admet-1474	304	9	735–747	735–747	NUM
admet-1474	304	10	.	.	PUNCT
admet-1474	305	1	https://doi.org/10.1080/10837450.2020.1740257	https://doi.org/10.1080/10837450.2020.1740257	X
admet-1474	305	2	.	.	PUNCT
admet-1474	306	1	[	[	X
admet-1474	306	2	6	6	NUM
admet-1474	306	3	]	]	PUNCT
admet-1474	306	4	d.	d.	PROPN
admet-1474	306	5	salat	salat	PROPN
admet-1474	306	6	,	,	PUNCT
admet-1474	306	7	e.	e.	PROPN
admet-1474	306	8	tolosa	tolosa	PROPN
admet-1474	306	9	.	.	PUNCT
admet-1474	307	1	levodopa	levodopa	NOUN
admet-1474	307	2	in	in	ADP
admet-1474	307	3	the	the	DET
admet-1474	307	4	treatment	treatment	NOUN
admet-1474	307	5	of	of	ADP
admet-1474	307	6	parkinson	parkinson	NOUN
admet-1474	307	7	’s	’s	PART
admet-1474	307	8	disease	disease	NOUN
admet-1474	307	9	:	:	PUNCT
admet-1474	307	10	current	current	ADJ
admet-1474	307	11	status	status	NOUN
admet-1474	307	12	and	and	CCONJ
admet-1474	307	13	new	new	ADJ
admet-1474	307	14	developments	development	NOUN
admet-1474	307	15	.	.	PUNCT
admet-1474	308	1	journal	journal	NOUN
admet-1474	308	2	of	of	ADP
admet-1474	308	3	parkinson	parkinson	NOUN
admet-1474	308	4	’s	’s	PART
admet-1474	308	5	disease	disease	NOUN
admet-1474	308	6	3	3	NUM
admet-1474	308	7	(	(	PUNCT
admet-1474	308	8	2013	2013	NUM
admet-1474	308	9	)	)	PUNCT
admet-1474	308	10	255–269	255–269	NUM
admet-1474	308	11	.	.	PUNCT
admet-1474	309	1	https://doi.org/10.3233/jpd130186	https://doi.org/10.3233/jpd130186	VERB
admet-1474	309	2	.	.	PUNCT
admet-1474	310	1	[	[	X
admet-1474	310	2	7	7	X
admet-1474	310	3	]	]	PUNCT
admet-1474	310	4	l.	l.	PROPN
admet-1474	310	5	wang	wang	PROPN
admet-1474	310	6	,	,	PUNCT
admet-1474	310	7	j.	j.	PROPN
admet-1474	310	8	li	li	PROPN
admet-1474	310	9	,	,	PUNCT
admet-1474	310	10	j.	j.	PROPN
admet-1474	310	11	chen	chen	PROPN
admet-1474	310	12	.	.	PUNCT
admet-1474	311	1	levodopa	levodopa	NOUN
admet-1474	311	2	-	-	PUNCT
admet-1474	311	3	carbidopa	carbidopa	NOUN
admet-1474	311	4	intestinal	intestinal	ADJ
admet-1474	311	5	gel	gel	NOUN
admet-1474	311	6	in	in	ADP
admet-1474	311	7	parkinson	parkinson	NOUN
admet-1474	311	8	’s	’s	PART
admet-1474	311	9	disease	disease	NOUN
admet-1474	311	10	:	:	PUNCT
admet-1474	311	11	a	a	DET
admet-1474	311	12	systematic	systematic	ADJ
admet-1474	311	13	review	review	NOUN
admet-1474	311	14	and	and	CCONJ
admet-1474	311	15	meta	meta	ADJ
admet-1474	311	16	-	-	PUNCT
admet-1474	311	17	analysis	analysis	NOUN
admet-1474	311	18	.	.	PUNCT
admet-1474	312	1	frontiers	frontier	NOUN
admet-1474	312	2	in	in	ADP
admet-1474	312	3	neurology	neurology	NOUN
admet-1474	312	4	9	9	NUM
admet-1474	312	5	(	(	PUNCT
admet-1474	312	6	2018	2018	NUM
admet-1474	312	7	)	)	PUNCT
admet-1474	312	8	.	.	PUNCT
admet-1474	313	1	https://doi.org/10.3389/fneur.2018.00620	https://doi.org/10.3389/fneur.2018.00620	PROPN
admet-1474	313	2	.	.	PUNCT
admet-1474	314	1	[	[	X
admet-1474	314	2	8	8	NUM
admet-1474	314	3	]	]	X
admet-1474	314	4	e.	e.	PROPN
admet-1474	314	5	garbayo	garbayo	PROPN
admet-1474	314	6	,	,	PUNCT
admet-1474	314	7	e.	e.	PROPN
admet-1474	314	8	ansorena	ansorena	PROPN
admet-1474	314	9	,	,	PUNCT
admet-1474	314	10	m.j	m.j	PROPN
admet-1474	314	11	.	.	PROPN
admet-1474	314	12	blanco	blanco	PROPN
admet-1474	314	13	-	-	PUNCT
admet-1474	314	14	prieto	prieto	NOUN
admet-1474	314	15	.	.	PUNCT
admet-1474	314	16	drug	drug	NOUN
admet-1474	314	17	development	development	NOUN
admet-1474	314	18	in	in	ADP
admet-1474	314	19	parkinson	parkinson	NOUN
admet-1474	314	20	’s	’s	PART
admet-1474	314	21	disease	disease	NOUN
admet-1474	314	22	:	:	PUNCT
admet-1474	314	23	from	from	ADP
admet-1474	314	24	emerging	emerge	VERB
admet-1474	314	25	molecules	molecule	NOUN
admet-1474	314	26	to	to	ADP
admet-1474	314	27	innovative	innovative	ADJ
admet-1474	314	28	drug	drug	NOUN
admet-1474	314	29	delivery	delivery	NOUN
admet-1474	314	30	systems	system	NOUN
admet-1474	314	31	.	.	PUNCT
admet-1474	315	1	maturitas	maturita	NOUN
admet-1474	315	2	76	76	NUM
admet-1474	315	3	(	(	PUNCT
admet-1474	315	4	2013	2013	NUM
admet-1474	315	5	)	)	PUNCT
admet-1474	315	6	272–278	272–278	NUM
admet-1474	315	7	.	.	PUNCT
admet-1474	316	1	https://doi.org/10.1016/j.maturitas.2013.05.019	https://doi.org/10.1016/j.maturitas.2013.05.019	X
admet-1474	316	2	.	.	PUNCT
admet-1474	317	1	[	[	X
admet-1474	317	2	9	9	NUM
admet-1474	317	3	]	]	X
admet-1474	317	4	m.e	m.e	PROPN
admet-1474	317	5	.	.	PROPN
admet-1474	317	6	freitas	freitas	PROPN
admet-1474	317	7	,	,	PUNCT
admet-1474	317	8	m.	m.	NOUN
admet-1474	317	9	ruiz	ruiz	NOUN
admet-1474	317	10	-	-	PUNCT
admet-1474	317	11	lopez	lopez	NOUN
admet-1474	317	12	,	,	PUNCT
admet-1474	317	13	s.h	s.h	PROPN
admet-1474	317	14	.	.	PROPN
admet-1474	317	15	fox	fox	PROPN
admet-1474	317	16	.	.	PUNCT
admet-1474	318	1	novel	novel	ADJ
admet-1474	318	2	levodopa	levodopa	NOUN
admet-1474	318	3	formulations	formulation	NOUN
admet-1474	318	4	for	for	ADP
admet-1474	318	5	parkinson	parkinson	NOUN
admet-1474	318	6	’s	’s	PART
admet-1474	318	7	disease	disease	NOUN
admet-1474	318	8	.	.	PUNCT
admet-1474	319	1	cns	cns	PROPN
admet-1474	319	2	drugs	drug	NOUN
admet-1474	319	3	30	30	NUM
admet-1474	319	4	(	(	PUNCT
admet-1474	319	5	2016	2016	NUM
admet-1474	319	6	)	)	PUNCT
admet-1474	319	7	1079–1095	1079–1095	NUM
admet-1474	319	8	.	.	PUNCT
admet-1474	319	9	https://doi.org/10.1007/s40263-016-0386-8	https://doi.org/10.1007/s40263-016-0386-8	PROPN
admet-1474	319	10	.	.	PUNCT
admet-1474	320	1	[	[	X
admet-1474	320	2	10	10	NUM
admet-1474	320	3	]	]	X
admet-1474	320	4	b.o	b.o	PROPN
admet-1474	320	5	.	.	PROPN
admet-1474	320	6	dankyi	dankyi	PROPN
admet-1474	320	7	,	,	PUNCT
admet-1474	320	8	s.k	s.k	PROPN
admet-1474	320	9	.	.	PROPN
admet-1474	320	10	amponsah	amponsah	PROPN
admet-1474	320	11	,	,	PUNCT
admet-1474	320	12	g.l	g.l	PROPN
admet-1474	320	13	.	.	PROPN
admet-1474	320	14	allotey	allotey	PROPN
admet-1474	320	15	-	-	PUNCT
admet-1474	320	16	babington	babington	PROPN
admet-1474	320	17	,	,	PUNCT
admet-1474	320	18	i.	i.	PROPN
admet-1474	320	19	adams	adams	PROPN
admet-1474	320	20	,	,	PUNCT
admet-1474	320	21	n.a	n.a	PROPN
admet-1474	320	22	.	.	PROPN
admet-1474	320	23	goode	goode	PROPN
admet-1474	320	24	,	,	PUNCT
admet-1474	320	25	h.	h.	PROPN
admet-1474	320	26	nettey	nettey	PROPN
admet-1474	320	27	.	.	PUNCT
admet-1474	321	1	chitosancoated	chitosancoate	VERB
admet-1474	321	2	hydroxypropylmethyl	hydroxypropylmethyl	PROPN
admet-1474	321	3	cellulose	cellulose	NOUN
admet-1474	321	4	microparticles	microparticle	NOUN
admet-1474	321	5	of	of	ADP
admet-1474	321	6	levodopa	levodopa	NOUN
admet-1474	321	7	(	(	PUNCT
admet-1474	321	8	and	and	CCONJ
admet-1474	321	9	carbidopa	carbidopa	ADV
admet-1474	321	10	):	):	PUNCT
admet-1474	321	11	in	in	ADP
admet-1474	321	12	vitro	vitro	X
admet-1474	321	13	and	and	CCONJ
admet-1474	321	14	rat	rat	NOUN
admet-1474	321	15	model	model	NOUN
admet-1474	321	16	kinetic	kinetic	NOUN
admet-1474	321	17	characteristics	characteristic	NOUN
admet-1474	321	18	.	.	PUNCT
admet-1474	322	1	current	current	ADJ
admet-1474	322	2	therapeutic	therapeutic	ADJ
admet-1474	322	3	research	research	NOUN
admet-1474	322	4	clinical	clinical	ADJ
admet-1474	322	5	and	and	CCONJ
admet-1474	322	6	experimental	experimental	ADJ
admet-1474	322	7	93	93	NUM
admet-1474	322	8	(	(	PUNCT
admet-1474	322	9	2020	2020	NUM
admet-1474	322	10	)	)	PUNCT
admet-1474	322	11	.	.	PUNCT
admet-1474	323	1	https://doi.org/10.1016/j.curtheres.2020.100612	https://doi.org/10.1016/j.curtheres.2020.100612	NOUN
admet-1474	323	2	.	.	PUNCT
admet-1474	324	1	[	[	X
admet-1474	324	2	11	11	NUM
admet-1474	324	3	]	]	X
admet-1474	324	4	b.a	b.a	PROPN
admet-1474	324	5	.	.	PROPN
admet-1474	324	6	sabel	sabel	PROPN
admet-1474	324	7	,	,	PUNCT
admet-1474	324	8	p.	p.	PROPN
admet-1474	324	9	dominiak	dominiak	PROPN
admet-1474	324	10	,	,	PUNCT
admet-1474	324	11	w.	w.	PROPN
admet-1474	324	12	hauser	hauser	PROPN
admet-1474	324	13	,	,	PUNCT
admet-1474	324	14	m.j	m.j	PROPN
admet-1474	324	15	.	.	PROPN
admet-1474	324	16	during	during	ADP
admet-1474	324	17	,	,	PUNCT
admet-1474	324	18	a.	a.	PROPN
admet-1474	324	19	freese	freese	PROPN
admet-1474	324	20	.	.	PUNCT
admet-1474	325	1	levodopa	levodopa	NOUN
admet-1474	325	2	delivery	delivery	NOUN
admet-1474	325	3	from	from	ADP
admet-1474	325	4	controlledrelease	controlledrelease	ADJ
admet-1474	325	5	polymer	polymer	NOUN
admet-1474	325	6	matrix	matrix	NOUN
admet-1474	325	7	:	:	PUNCT
admet-1474	325	8	delivery	delivery	NOUN
admet-1474	325	9	of	of	ADP
admet-1474	325	10	more	more	ADJ
admet-1474	325	11	than	than	ADP
admet-1474	325	12	600	600	NUM
admet-1474	325	13	days	day	NOUN
admet-1474	325	14	in	in	ADP
admet-1474	325	15	vitro	vitro	X
admet-1474	325	16	and	and	CCONJ
admet-1474	325	17	225	225	NUM
admet-1474	325	18	days	day	NOUN
admet-1474	325	19	of	of	ADP
admet-1474	325	20	elevated	elevated	ADJ
admet-1474	325	21	plasma	plasma	NOUN
admet-1474	325	22	levels	level	NOUN
admet-1474	325	23	after	after	ADP
admet-1474	325	24	subcutaneous	subcutaneous	ADJ
admet-1474	325	25	implantation	implantation	NOUN
admet-1474	325	26	in	in	ADP
admet-1474	325	27	rats	rat	NOUN
admet-1474	325	28	.	.	PUNCT
admet-1474	326	1	journal	journal	NOUN
admet-1474	326	2	of	of	ADP
admet-1474	326	3	pharmacology	pharmacology	NOUN
admet-1474	326	4	and	and	CCONJ
admet-1474	326	5	experimental	experimental	ADJ
admet-1474	326	6	therapeutics	therapeutic	NOUN
admet-1474	326	7	255	255	NUM
admet-1474	326	8	(	(	PUNCT
admet-1474	326	9	1990	1990	NUM
admet-1474	326	10	)	)	PUNCT
admet-1474	326	11	914–922	914–922	NUM
admet-1474	326	12	.	.	PUNCT
admet-1474	327	1	[	[	X
admet-1474	327	2	12	12	NUM
admet-1474	327	3	]	]	X
admet-1474	327	4	n.c	n.c	PROPN
admet-1474	327	5	.	.	PROPN
admet-1474	327	6	ngwuluka	ngwuluka	PROPN
admet-1474	327	7	,	,	PUNCT
admet-1474	327	8	e.i	e.i	PROPN
admet-1474	327	9	.	.	PROPN
admet-1474	328	1	nep	nep	PROPN
admet-1474	328	2	,	,	PUNCT
admet-1474	328	3	n.a	n.a	PROPN
admet-1474	328	4	.	.	PROPN
admet-1474	328	5	ochekpe	ochekpe	PROPN
admet-1474	328	6	,	,	PUNCT
admet-1474	328	7	p.o	p.o	PROPN
admet-1474	328	8	.	.	PROPN
admet-1474	328	9	odumosu	odumosu	PROPN
admet-1474	328	10	,	,	PUNCT
admet-1474	328	11	p.o	p.o	PROPN
admet-1474	328	12	.	.	PROPN
admet-1474	328	13	olorunfemi	olorunfemi	PROPN
admet-1474	328	14	.	.	PUNCT
admet-1474	329	1	eudragit	eudragit	PROPN
admet-1474	329	2	e100	e100	PROPN
admet-1474	329	3	and	and	CCONJ
admet-1474	329	4	polysaccharide	polysaccharide	ADJ
admet-1474	329	5	polymer	polymer	NOUN
admet-1474	329	6	blends	blend	NOUN
admet-1474	329	7	as	as	ADP
admet-1474	329	8	matrices	matrix	NOUN
admet-1474	329	9	for	for	ADP
admet-1474	329	10	modified	modify	VERB
admet-1474	329	11	-	-	PUNCT
admet-1474	329	12	release	release	NOUN
admet-1474	329	13	drug	drug	NOUN
admet-1474	329	14	delivery	delivery	NOUN
admet-1474	329	15	ii	ii	PROPN
admet-1474	329	16	:	:	PUNCT
admet-1474	329	17	swelling	swell	VERB
admet-1474	329	18	and	and	CCONJ
admet-1474	329	19	release	release	NOUN
admet-1474	329	20	studies	study	NOUN
admet-1474	329	21	.	.	PUNCT
admet-1474	330	1	tropical	tropical	ADJ
admet-1474	330	2	journal	journal	PROPN
admet-1474	330	3	of	of	ADP
admet-1474	330	4	pharmaceutical	pharmaceutical	ADJ
admet-1474	330	5	research	research	NOUN
admet-1474	330	6	14	14	NUM
admet-1474	330	7	(	(	PUNCT
admet-1474	330	8	2015	2015	NUM
admet-1474	330	9	)	)	PUNCT
admet-1474	330	10	2163–2170	2163–2170	NUM
admet-1474	330	11	.	.	PUNCT
admet-1474	331	1	https://doi.org/10.4314/tjpr.v14i12.2	https://doi.org/10.4314/tjpr.v14i12.2	PROPN
admet-1474	331	2	.	.	PUNCT
admet-1474	332	1	[	[	X
admet-1474	332	2	13	13	NUM
admet-1474	332	3	]	]	X
admet-1474	332	4	o.	o.	PROPN
admet-1474	332	5	adi	adi	PROPN
admet-1474	332	6	-	-	PUNCT
admet-1474	332	7	dako	dako	PROPN
admet-1474	332	8	,	,	PUNCT
admet-1474	332	9	k.	k.	PROPN
admet-1474	332	10	ofori	ofori	PROPN
admet-1474	332	11	-	-	PUNCT
admet-1474	332	12	kwakye	kwakye	NOUN
admet-1474	332	13	,	,	PUNCT
admet-1474	332	14	s.	s.	PROPN
admet-1474	332	15	frimpong	frimpong	PROPN
admet-1474	332	16	manso	manso	PROPN
admet-1474	332	17	,	,	PUNCT
admet-1474	332	18	m.	m.	NOUN
admet-1474	332	19	el	el	PROPN
admet-1474	332	20	boakye	boakye	PROPN
admet-1474	332	21	-	-	PUNCT
admet-1474	332	22	gyasi	gyasi	NOUN
admet-1474	332	23	,	,	PUNCT
admet-1474	332	24	c.	c.	PROPN
admet-1474	332	25	sasu	sasu	PROPN
admet-1474	332	26	,	,	PUNCT
admet-1474	332	27	m.	m.	NOUN
admet-1474	332	28	pobee	pobee	NOUN
admet-1474	332	29	.	.	PUNCT
admet-1474	333	1	physicochemical	physicochemical	ADJ
admet-1474	333	2	and	and	CCONJ
admet-1474	333	3	antimicrobial	antimicrobial	ADJ
admet-1474	333	4	properties	property	NOUN
admet-1474	333	5	of	of	ADP
admet-1474	333	6	cocoa	cocoa	NOUN
admet-1474	333	7	pod	pod	PROPN
admet-1474	333	8	husk	husk	NOUN
admet-1474	333	9	pectin	pectin	NOUN
admet-1474	333	10	intended	intend	VERB
admet-1474	333	11	as	as	ADP
admet-1474	333	12	a	a	DET
admet-1474	333	13	versatile	versatile	ADJ
admet-1474	333	14	pharmaceutical	pharmaceutical	ADJ
admet-1474	333	15	excipient	excipient	NOUN
admet-1474	333	16	and	and	CCONJ
admet-1474	333	17	nutraceutical	nutraceutical	ADJ
admet-1474	333	18	.	.	PUNCT
admet-1474	334	1	journal	journal	PROPN
admet-1474	334	2	of	of	ADP
admet-1474	334	3	pharmaceutics	pharmaceutic	NOUN
admet-1474	334	4	2016	2016	NUM
admet-1474	334	5	(	(	PUNCT
admet-1474	334	6	2016	2016	NUM
admet-1474	334	7	)	)	PUNCT
admet-1474	334	8	1–12	1–12	NOUN
admet-1474	334	9	.	.	PUNCT
admet-1474	335	1	https://doi.org/10.1155/2016/7608693	https://doi.org/10.1155/2016/7608693	PROPN
admet-1474	335	2	.	.	PUNCT
admet-1474	336	1	[	[	X
admet-1474	336	2	14	14	NUM
admet-1474	336	3	]	]	X
admet-1474	336	4	o.	o.	PROPN
admet-1474	336	5	adi	adi	PROPN
admet-1474	336	6	-	-	PUNCT
admet-1474	336	7	dako	dako	PROPN
admet-1474	336	8	,	,	PUNCT
admet-1474	336	9	k.	k.	PROPN
admet-1474	336	10	ofori	ofori	PROPN
admet-1474	336	11	-	-	PUNCT
admet-1474	336	12	kwakye	kwakye	ADJ
admet-1474	336	13	,	,	PUNCT
admet-1474	336	14	k.k.e	k.k.e	NOUN
admet-1474	336	15	.	.	PUNCT
admet-1474	336	16	kukuia	kukuia	PROPN
admet-1474	336	17	,	,	PUNCT
admet-1474	336	18	j.	j.	PROPN
admet-1474	336	19	asiedu	asiedu	PROPN
admet-1474	336	20	-	-	PUNCT
admet-1474	336	21	larbi	larbi	NOUN
admet-1474	336	22	,	,	PUNCT
admet-1474	336	23	a.	a.	NOUN
admet-1474	336	24	nyarko	nyarko	PROPN
admet-1474	336	25	,	,	PUNCT
admet-1474	336	26	d.	d.	PROPN
admet-1474	336	27	kumadoh	kumadoh	PROPN
admet-1474	336	28	,	,	PUNCT
admet-1474	336	29	c.	c.	PROPN
admet-1474	336	30	osei	osei	PROPN
admet-1474	336	31	-	-	PUNCT
admet-1474	336	32	asare	asare	PROPN
admet-1474	336	33	.	.	PUNCT
admet-1474	337	1	subchronic	subchronic	ADJ
admet-1474	337	2	toxicity	toxicity	NOUN
admet-1474	337	3	studies	study	NOUN
admet-1474	337	4	of	of	ADP
admet-1474	337	5	cocoa	cocoa	PROPN
admet-1474	337	6	pod	pod	PROPN
admet-1474	337	7	husk	husk	NOUN
admet-1474	337	8	pectin	pectin	NOUN
admet-1474	337	9	intended	intend	VERB
admet-1474	337	10	as	as	ADP
admet-1474	337	11	a	a	DET
admet-1474	337	12	pharmaceutical	pharmaceutical	ADJ
admet-1474	337	13	excipient	excipient	NOUN
admet-1474	337	14	in	in	ADP
admet-1474	337	15	sprague	sprague	PROPN
admet-1474	337	16	dawley	dawley	NOUN
admet-1474	337	17	rats	rat	NOUN
admet-1474	337	18	.	.	PUNCT
admet-1474	338	1	journal	journal	NOUN
admet-1474	338	2	of	of	ADP
admet-1474	338	3	pharmacy	pharmacy	NOUN
admet-1474	338	4	and	and	CCONJ
admet-1474	338	5	pharmacognosy	pharmacognosy	NOUN
admet-1474	338	6	research	research	NOUN
admet-1474	338	7	6	6	NUM
admet-1474	338	8	(	(	PUNCT
admet-1474	338	9	2018	2018	NUM
admet-1474	338	10	)	)	PUNCT
admet-1474	338	11	271–284	271–284	NUM
admet-1474	338	12	.	.	PUNCT
admet-1474	339	1	http://jppres.com/jppres	http://jppres.com/jppres	X
admet-1474	339	2	(	(	PUNCT
admet-1474	339	3	accessed	access	VERB
admet-1474	339	4	april	april	PROPN
admet-1474	339	5	19	19	NUM
admet-1474	339	6	,	,	PUNCT
admet-1474	339	7	2022	2022	NUM
admet-1474	339	8	)	)	PUNCT
admet-1474	339	9	.	.	PUNCT
admet-1474	340	1	[	[	X
admet-1474	340	2	15	15	NUM
admet-1474	340	3	]	]	X
admet-1474	340	4	o.	o.	PROPN
admet-1474	340	5	adi	adi	PROPN
admet-1474	340	6	-	-	PUNCT
admet-1474	340	7	dako	dako	PROPN
admet-1474	340	8	,	,	PUNCT
admet-1474	340	9	k.	k.	PROPN
admet-1474	340	10	ofori	ofori	PROPN
admet-1474	340	11	-	-	PUNCT
admet-1474	340	12	kwakye	kwakye	ADJ
admet-1474	340	13	,	,	PUNCT
admet-1474	340	14	k.k.e	k.k.e	NOUN
admet-1474	340	15	.	.	PUNCT
admet-1474	340	16	kukuia	kukuia	PROPN
admet-1474	340	17	,	,	PUNCT
admet-1474	340	18	j.	j.	PROPN
admet-1474	340	19	asiedu	asiedu	PROPN
admet-1474	340	20	-	-	PUNCT
admet-1474	340	21	larbi	larbi	NOUN
admet-1474	340	22	,	,	PUNCT
admet-1474	340	23	a.k	a.k	PROPN
admet-1474	340	24	.	.	PROPN
admet-1474	340	25	nyarko	nyarko	PROPN
admet-1474	340	26	,	,	PUNCT
admet-1474	340	27	d.	d.	PROPN
admet-1474	340	28	kumadoh	kumadoh	PROPN
admet-1474	340	29	,	,	PUNCT
admet-1474	340	30	g.	g.	PROPN
admet-1474	340	31	frimpong	frimpong	PROPN
admet-1474	340	32	.	.	PUNCT
admet-1474	341	1	cocoa	cocoa	PROPN
admet-1474	341	2	pod	pod	PROPN
admet-1474	341	3	husk	husk	NOUN
admet-1474	341	4	pectin	pectin	NOUN
admet-1474	341	5	intended	intend	VERB
admet-1474	341	6	as	as	ADP
admet-1474	341	7	a	a	DET
admet-1474	341	8	pharmaceutical	pharmaceutical	ADJ
admet-1474	341	9	excipient	excipient	NOUN
admet-1474	341	10	has	have	VERB
admet-1474	341	11	no	no	DET
admet-1474	341	12	adverse	adverse	ADJ
admet-1474	341	13	effects	effect	NOUN
admet-1474	341	14	on	on	ADP
admet-1474	341	15	haematological	haematological	ADJ
admet-1474	341	16	parameters	parameter	NOUN
admet-1474	341	17	in	in	ADP
admet-1474	341	18	sprague	sprague	PROPN
admet-1474	341	19	dawley	dawley	NOUN
admet-1474	341	20	rats	rat	NOUN
admet-1474	341	21	.	.	PUNCT
admet-1474	342	1	journal	journal	NOUN
admet-1474	342	2	of	of	ADP
admet-1474	342	3	pharmaceutics	pharmaceutic	NOUN
admet-1474	342	4	2018	2018	NUM
admet-1474	342	5	(	(	PUNCT
admet-1474	342	6	2018	2018	NUM
admet-1474	342	7	)	)	PUNCT
admet-1474	342	8	1–10	1–10	NOUN
admet-1474	342	9	.	.	PUNCT
admet-1474	343	1	https://doi.org/10.1155/2018/1459849	https://doi.org/10.1155/2018/1459849	PROPN
admet-1474	343	2	.	.	PUNCT
admet-1474	344	1	[	[	X
admet-1474	344	2	16	16	NUM
admet-1474	344	3	]	]	PUNCT
admet-1474	344	4	s.	s.	PROPN
admet-1474	344	5	jagan	jagan	PROPN
admet-1474	344	6	mohan	mohan	PROPN
admet-1474	344	7	,	,	PUNCT
admet-1474	344	8	v.	v.	PROPN
admet-1474	344	9	kishan	kishan	PROPN
admet-1474	344	10	,	,	PUNCT
admet-1474	344	11	y.	y.	PROPN
admet-1474	344	12	madhusudan	madhusudan	PROPN
admet-1474	344	13	rao	rao	PROPN
admet-1474	344	14	,	,	PUNCT
admet-1474	344	15	n.	n.	PROPN
admet-1474	344	16	v.	v.	ADP
admet-1474	344	17	chalapathi	chalapathi	PROPN
admet-1474	344	18	rao	rao	PROPN
admet-1474	344	19	.	.	PUNCT
admet-1474	345	1	formulation	formulation	NOUN
admet-1474	345	2	of	of	ADP
admet-1474	345	3	controlled	control	VERB
admet-1474	345	4	release	release	NOUN
admet-1474	345	5	levodopa	levodopa	NOUN
admet-1474	345	6	and	and	CCONJ
admet-1474	345	7	carbidopa	carbidopa	NOUN
admet-1474	345	8	matrix	matrix	NOUN
admet-1474	345	9	tablets	tablet	NOUN
admet-1474	345	10	:	:	PUNCT
admet-1474	345	11	influence	influence	NOUN
admet-1474	345	12	of	of	ADP
admet-1474	345	13	some	some	DET
admet-1474	345	14	hydrophilic	hydrophilic	ADJ
admet-1474	345	15	polymers	polymer	NOUN
admet-1474	345	16	on	on	ADP
admet-1474	345	17	the	the	DET
admet-1474	345	18	release	release	NOUN
admet-1474	345	19	rate	rate	NOUN
admet-1474	345	20	and	and	CCONJ
admet-1474	345	21	in	in	ADP
admet-1474	345	22	vitro	vitro	X
admet-1474	345	23	evaluation	evaluation	NOUN
admet-1474	345	24	.	.	PUNCT
admet-1474	346	1	current	current	ADJ
admet-1474	346	2	trends	trend	NOUN
admet-1474	346	3	in	in	ADP
admet-1474	346	4	biotechnology	biotechnology	NOUN
admet-1474	346	5	and	and	CCONJ
admet-1474	346	6	pharmacy	pharmacy	NOUN
admet-1474	346	7	3	3	NUM
admet-1474	346	8	(	(	PUNCT
admet-1474	346	9	2009	2009	NUM
admet-1474	346	10	)	)	PUNCT
admet-1474	346	11	204209	204209	NUM
admet-1474	346	12	.	.	PUNCT
admet-1474	347	1	[	[	X
admet-1474	347	2	17	17	NUM
admet-1474	347	3	]	]	X
admet-1474	347	4	p.s	p.s	PROPN
admet-1474	347	5	.	.	PROPN
admet-1474	347	6	avhad	avhad	PROPN
admet-1474	347	7	,	,	PUNCT
admet-1474	347	8	r.a	r.a	PROPN
admet-1474	347	9	.	.	PROPN
admet-1474	347	10	gupta	gupta	PROPN
admet-1474	347	11	,	,	PUNCT
admet-1474	347	12	s.n	s.n	PROPN
admet-1474	347	13	.	.	PROPN
admet-1474	347	14	firke	firke	PROPN
admet-1474	347	15	,	,	PUNCT
admet-1474	347	16	a.b	a.b	PROPN
admet-1474	347	17	.	.	PROPN
admet-1474	347	18	roge	roge	PROPN
admet-1474	347	19	,	,	PUNCT
admet-1474	347	20	s.k	s.k	PROPN
admet-1474	347	21	.	.	PROPN
admet-1474	347	22	sarje	sarje	PROPN
admet-1474	347	23	,	,	PUNCT
admet-1474	347	24	a.s	a.s	PROPN
admet-1474	347	25	.	.	PROPN
admet-1474	347	26	raut	raut	PROPN
admet-1474	347	27	,	,	PUNCT
admet-1474	347	28	r.	r.	PROPN
admet-1474	347	29	devaliya	devaliya	PROPN
admet-1474	347	30	.	.	PUNCT
admet-1474	348	1	formulation	formulation	NOUN
admet-1474	348	2	and	and	CCONJ
admet-1474	348	3	evaluation	evaluation	NOUN
admet-1474	348	4	of	of	ADP
admet-1474	348	5	chitosan	chitosan	NOUN
admet-1474	348	6	based	base	VERB
admet-1474	348	7	polyelectrolyte	polyelectrolyte	PROPN
admet-1474	348	8	complex	complex	NOUN
admet-1474	348	9	of	of	ADP
admet-1474	348	10	levodopa	levodopa	NOUN
admet-1474	348	11	for	for	ADP
admet-1474	348	12	nasal	nasal	ADJ
admet-1474	348	13	drug	drug	NOUN
admet-1474	348	14	delivery	delivery	NOUN
admet-1474	348	15	.	.	PUNCT
admet-1474	349	1	international	international	ADJ
admet-1474	349	2	journal	journal	PROPN
admet-1474	349	3	of	of	ADP
admet-1474	349	4	health	health	PROPN
admet-1474	349	5	sciences	sciences	PROPN
admet-1474	349	6	6	6	NUM
admet-1474	349	7	(	(	PUNCT
admet-1474	349	8	2022	2022	NUM
admet-1474	349	9	)	)	PUNCT
admet-1474	349	10	1316	1316	NUM
admet-1474	349	11	-	-	SYM
admet-1474	349	12	1327	1327	NUM
admet-1474	349	13	.	.	PUNCT
admet-1474	350	1	https://doi.org/10.53730/ijhs.v6ns3.5555	https://doi.org/10.53730/ijhs.v6ns3.5555	NOUN
admet-1474	350	2	.	.	PUNCT
admet-1474	350	3	https://doi.org/10.14802/jmd.17028	https://doi.org/10.14802/jmd.17028	PROPN
admet-1474	350	4	https://doi.org/10.1080/10837450.2020.1740257	https://doi.org/10.1080/10837450.2020.1740257	NOUN
admet-1474	351	1	https://doi.org/10.3233/jpd-130186	https://doi.org/10.3233/jpd-130186	X
admet-1474	351	2	https://doi.org/10.3233/jpd-130186	https://doi.org/10.3233/jpd-130186	NUM
admet-1474	351	3	https://doi.org/10.3389/fneur.2018.00620	https://doi.org/10.3389/fneur.2018.00620	PROPN
admet-1474	351	4	https://doi.org/10.3389/fneur.2018.00620	https://doi.org/10.3389/fneur.2018.00620	PROPN
admet-1474	351	5	https://doi.org/10.1016/j.maturitas.2013.05.019	https://doi.org/10.1016/j.maturitas.2013.05.019	PROPN
admet-1474	351	6	https://doi.org/10.1007/s40263-016-0386-8	https://doi.org/10.1007/s40263-016-0386-8	NUM
admet-1474	351	7	https://doi.org/10.1016/j.curtheres.2020.100612	https://doi.org/10.1016/j.curtheres.2020.100612	ADJ
admet-1474	351	8	https://doi.org/10.4314/tjpr.v14i12.2	https://doi.org/10.4314/tjpr.v14i12.2	NOUN
admet-1474	351	9	https://doi.org/10.1155/2016/7608693	https://doi.org/10.1155/2016/7608693	PROPN
admet-1474	351	10	http://jppres.com/jppres	http://jppres.com/jppre	NOUN
admet-1474	351	11	https://doi.org/10.1155/2018/1459849	https://doi.org/10.1155/2018/1459849	VERB
admet-1474	351	12	https://doi.org/10.53730/ijhs.v6ns3.5555	https://doi.org/10.53730/ijhs.v6ns3.5555	PROPN
admet-1474	351	13	https://doi.org/10.53730/ijhs.v6ns3.5555	https://doi.org/10.53730/ijhs.v6ns3.5555	PROPN
admet-1474	351	14	admet	admet	PROPN
admet-1474	351	15	&	&	CCONJ
admet-1474	351	16	dmpk	dmpk	PROPN
admet-1474	351	17	11(1	11(1	NUM
admet-1474	351	18	)	)	PUNCT
admet-1474	351	19	(	(	PUNCT
admet-1474	351	20	2023	2023	NUM
admet-1474	351	21	)	)	PUNCT
admet-1474	351	22	97	97	NUM
admet-1474	351	23	-	-	SYM
admet-1474	351	24	115	115	NUM
admet-1474	351	25	evaluation	evaluation	NOUN
admet-1474	351	26	of	of	ADP
admet-1474	351	27	re	re	ADJ
admet-1474	351	28	-	-	ADJ
admet-1474	351	29	formulated	formulate	VERB
admet-1474	351	30	levodopa	levodopa	NOUN
admet-1474	351	31	and	and	CCONJ
admet-1474	351	32	carbidopa	carbidopa	NOUN
admet-1474	351	33	doi	doi	NOUN
admet-1474	351	34	:	:	PUNCT
admet-1474	351	35	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	351	36	113	113	NUM
admet-1474	351	37	[	[	SYM
admet-1474	351	38	18	18	NUM
admet-1474	351	39	]	]	PUNCT
admet-1474	351	40	a.	a.	NOUN
admet-1474	351	41	shohreh	shohreh	NOUN
admet-1474	351	42	,	,	PUNCT
admet-1474	351	43	m.	m.	NOUN
admet-1474	351	44	asef	asef	NOUN
admet-1474	351	45	,	,	PUNCT
admet-1474	351	46	a.	a.	NOUN
admet-1474	351	47	fatemeh	fatemeh	NOUN
admet-1474	351	48	.	.	PUNCT
admet-1474	352	1	simple	simple	ADJ
admet-1474	352	2	and	and	CCONJ
admet-1474	352	3	rapid	rapid	ADJ
admet-1474	352	4	hplc	hplc	NOUN
admet-1474	352	5	method	method	NOUN
admet-1474	352	6	for	for	ADP
admet-1474	352	7	simultaneous	simultaneous	ADJ
admet-1474	352	8	quantification	quantification	NOUN
admet-1474	352	9	of	of	ADP
admet-1474	352	10	levodopa	levodopa	NOUN
admet-1474	352	11	and	and	CCONJ
admet-1474	352	12	carbidopa	carbidopa	NOUN
admet-1474	352	13	in	in	ADP
admet-1474	352	14	a	a	DET
admet-1474	352	15	fast	fast	ADJ
admet-1474	352	16	disintegrating	disintegrate	VERB
admet-1474	352	17	tablet	tablet	NOUN
admet-1474	352	18	formulation	formulation	NOUN
admet-1474	352	19	.	.	PUNCT
admet-1474	353	1	international	international	ADJ
admet-1474	353	2	journal	journal	PROPN
admet-1474	353	3	of	of	ADP
admet-1474	353	4	applied	apply	VERB
admet-1474	353	5	pharmaceutics	pharmaceutic	NOUN
admet-1474	353	6	11	11	NUM
admet-1474	353	7	(	(	PUNCT
admet-1474	353	8	2019	2019	NUM
admet-1474	353	9	)	)	PUNCT
admet-1474	353	10	200–205	200–205	NUM
admet-1474	353	11	.	.	PUNCT
admet-1474	354	1	https://doi.org/10.22159/ijap.2019v11i3.30676	https://doi.org/10.22159/ijap.2019v11i3.30676	PUNCT
admet-1474	354	2	.	.	PUNCT
admet-1474	355	1	[	[	X
admet-1474	355	2	19	19	NUM
admet-1474	355	3	]	]	X
admet-1474	355	4	n.c	n.c	PROPN
admet-1474	355	5	.	.	PROPN
admet-1474	355	6	ngwuluka	ngwuluka	PROPN
admet-1474	355	7	,	,	PUNCT
admet-1474	355	8	y.e	y.e	PROPN
admet-1474	355	9	.	.	PROPN
admet-1474	355	10	choonara	choonara	PROPN
admet-1474	355	11	,	,	PUNCT
admet-1474	355	12	g.	g.	PROPN
admet-1474	355	13	modi	modi	PROPN
admet-1474	355	14	,	,	PUNCT
admet-1474	355	15	l.c	l.c	PROPN
admet-1474	355	16	.	.	PROPN
admet-1474	355	17	du	du	PROPN
admet-1474	355	18	toit	toit	PROPN
admet-1474	355	19	,	,	PUNCT
admet-1474	355	20	p.	p.	PROPN
admet-1474	355	21	kumar	kumar	PROPN
admet-1474	355	22	,	,	PUNCT
admet-1474	355	23	v.m.k	v.m.k	PROPN
admet-1474	355	24	.	.	PUNCT
admet-1474	356	1	ndesendo	ndesendo	PROPN
admet-1474	356	2	,	,	PUNCT
admet-1474	356	3	v.	v.	PROPN
admet-1474	356	4	pillay	pillay	PROPN
admet-1474	356	5	.	.	PUNCT
admet-1474	357	1	design	design	NOUN
admet-1474	357	2	of	of	ADP
admet-1474	357	3	an	an	DET
admet-1474	357	4	interpolyelectrolyte	interpolyelectrolyte	NOUN
admet-1474	357	5	gastroretentive	gastroretentive	ADJ
admet-1474	357	6	matrix	matrix	NOUN
admet-1474	357	7	for	for	ADP
admet-1474	357	8	the	the	DET
admet-1474	357	9	site	site	NOUN
admet-1474	357	10	-	-	PUNCT
admet-1474	357	11	specific	specific	ADJ
admet-1474	357	12	zero	zero	NUM
admet-1474	357	13	-	-	PUNCT
admet-1474	357	14	order	order	NOUN
admet-1474	357	15	delivery	delivery	NOUN
admet-1474	357	16	of	of	ADP
admet-1474	357	17	levodopa	levodopa	NOUN
admet-1474	357	18	in	in	ADP
admet-1474	357	19	parkinson	parkinson	NOUN
admet-1474	357	20	’s	’s	PART
admet-1474	357	21	disease	disease	NOUN
admet-1474	357	22	.	.	PUNCT
admet-1474	358	1	aaps	aap	NOUN
admet-1474	358	2	pharmscitech	pharmscitech	VERB
admet-1474	358	3	14	14	NUM
admet-1474	358	4	(	(	PUNCT
admet-1474	358	5	2013	2013	NUM
admet-1474	358	6	)	)	PUNCT
admet-1474	358	7	605–619	605–619	NUM
admet-1474	358	8	.	.	PUNCT
admet-1474	359	1	https://doi.org/10.1208/s12249-013-9945-1	https://doi.org/10.1208/s12249-013-9945-1	NOUN
admet-1474	359	2	.	.	PUNCT
admet-1474	360	1	[	[	X
admet-1474	360	2	20	20	NUM
admet-1474	360	3	]	]	X
admet-1474	360	4	l.c	l.c	PROPN
admet-1474	360	5	.	.	PROPN
admet-1474	360	6	popa	popa	PROPN
admet-1474	360	7	,	,	PUNCT
admet-1474	360	8	d.c	d.c	PROPN
admet-1474	360	9	.	.	PROPN
admet-1474	360	10	leucuta	leucuta	PROPN
admet-1474	360	11	,	,	PUNCT
admet-1474	360	12	n.	n.	PROPN
admet-1474	360	13	tohanean	tohanean	PROPN
admet-1474	360	14	,	,	PUNCT
admet-1474	360	15	s.l	s.l	PROPN
admet-1474	360	16	.	.	PROPN
admet-1474	360	17	popa	popa	PROPN
admet-1474	360	18	,	,	PUNCT
admet-1474	360	19	l.	l.	PROPN
admet-1474	360	20	perju	perju	PROPN
admet-1474	360	21	-	-	PUNCT
admet-1474	360	22	dumbrava	dumbrava	PROPN
admet-1474	360	23	.	.	PUNCT
admet-1474	361	1	intrajejunal	intrajejunal	ADJ
admet-1474	361	2	vs	vs	ADP
admet-1474	361	3	oral	oral	ADJ
admet-1474	361	4	levodopacarbidopa	levodopacarbidopa	ADJ
admet-1474	361	5	therapy	therapy	NOUN
admet-1474	361	6	in	in	ADP
admet-1474	361	7	parkinson	parkinson	NOUN
admet-1474	361	8	disease	disease	NOUN
admet-1474	361	9	:	:	PUNCT
admet-1474	361	10	a	a	DET
admet-1474	361	11	retrospective	retrospective	ADJ
admet-1474	361	12	cohort	cohort	NOUN
admet-1474	361	13	study	study	NOUN
admet-1474	361	14	.	.	PUNCT
admet-1474	362	1	medicine	medicine	NOUN
admet-1474	362	2	99	99	NUM
admet-1474	362	3	(	(	PUNCT
admet-1474	362	4	2020	2020	NUM
admet-1474	362	5	)	)	PUNCT
admet-1474	362	6	e23249	e23249	NOUN
admet-1474	362	7	.	.	PUNCT
admet-1474	363	1	https://doi.org/10.1097/md.0000000000023249	https://doi.org/10.1097/md.0000000000023249	X
admet-1474	363	2	.	.	PUNCT
admet-1474	364	1	[	[	X
admet-1474	364	2	21	21	NUM
admet-1474	364	3	]	]	PUNCT
admet-1474	364	4	m.	m.	NOUN
admet-1474	364	5	rosebraugh	rosebraugh	NOUN
admet-1474	364	6	,	,	PUNCT
admet-1474	364	7	h.	h.	PROPN
admet-1474	364	8	v.	v.	PROPN
admet-1474	364	9	kalluri	kalluri	PROPN
admet-1474	364	10	,	,	PUNCT
admet-1474	364	11	w.	w.	PROPN
admet-1474	364	12	liu	liu	PROPN
admet-1474	364	13	,	,	PUNCT
admet-1474	364	14	c.	c.	PROPN
admet-1474	364	15	locke	locke	PROPN
admet-1474	364	16	,	,	PUNCT
admet-1474	364	17	d.	d.	PROPN
admet-1474	364	18	sidhu	sidhu	PROPN
admet-1474	364	19	,	,	PUNCT
admet-1474	364	20	j.h	j.h	PROPN
admet-1474	364	21	.	.	PROPN
admet-1474	364	22	han	han	PROPN
admet-1474	364	23	,	,	PUNCT
admet-1474	364	24	j.	j.	PROPN
admet-1474	364	25	benesh	benesh	PROPN
admet-1474	364	26	.	.	PUNCT
admet-1474	365	1	levodopa	levodopa	NOUN
admet-1474	365	2	-	-	PUNCT
admet-1474	365	3	carbidopa	carbidopa	NOUN
admet-1474	365	4	intestinal	intestinal	ADJ
admet-1474	365	5	gel	gel	NOUN
admet-1474	365	6	high	high	ADJ
admet-1474	365	7	concentration	concentration	NOUN
admet-1474	365	8	formulation	formulation	NOUN
admet-1474	365	9	is	be	AUX
admet-1474	365	10	clinically	clinically	ADV
admet-1474	365	11	bioequivalent	bioequivalent	NOUN
admet-1474	365	12	to	to	ADP
admet-1474	365	13	commercial	commercial	ADJ
admet-1474	365	14	formulation	formulation	NOUN
admet-1474	365	15	.	.	PUNCT
admet-1474	366	1	pharmacology	pharmacology	NOUN
admet-1474	366	2	research	research	NOUN
admet-1474	366	3	and	and	CCONJ
admet-1474	366	4	perspectives	perspective	NOUN
admet-1474	366	5	7	7	NUM
admet-1474	366	6	(	(	PUNCT
admet-1474	366	7	2019	2019	NUM
admet-1474	366	8	)	)	PUNCT
admet-1474	366	9	.	.	PUNCT
admet-1474	367	1	https://doi.org/10.1002/prp2.473	https://doi.org/10.1002/prp2.473	PROPN
admet-1474	367	2	.	.	PUNCT
admet-1474	368	1	[	[	X
admet-1474	368	2	22	22	NUM
admet-1474	368	3	]	]	X
admet-1474	368	4	national	national	PROPN
admet-1474	368	5	research	research	PROPN
admet-1474	368	6	council	council	PROPN
admet-1474	368	7	.	.	PUNCT
admet-1474	369	1	guide	guide	VERB
admet-1474	369	2	for	for	ADP
admet-1474	369	3	the	the	DET
admet-1474	369	4	care	care	NOUN
admet-1474	369	5	and	and	CCONJ
admet-1474	369	6	use	use	NOUN
admet-1474	369	7	of	of	ADP
admet-1474	369	8	laboratory	laboratory	NOUN
admet-1474	369	9	animals	animal	NOUN
admet-1474	369	10	committee	committee	NOUN
admet-1474	369	11	for	for	ADP
admet-1474	369	12	the	the	DET
admet-1474	369	13	update	update	NOUN
admet-1474	369	14	of	of	ADP
admet-1474	369	15	the	the	DET
admet-1474	369	16	guide	guide	NOUN
admet-1474	369	17	for	for	ADP
admet-1474	369	18	the	the	DET
admet-1474	369	19	care	care	NOUN
admet-1474	369	20	and	and	CCONJ
admet-1474	369	21	use	use	NOUN
admet-1474	369	22	of	of	ADP
admet-1474	369	23	laboratory	laboratory	NOUN
admet-1474	369	24	animals	animal	NOUN
admet-1474	369	25	,	,	PUNCT
admet-1474	369	26	institute	institute	NOUN
admet-1474	369	27	for	for	ADP
admet-1474	369	28	laboratory	laboratory	NOUN
admet-1474	369	29	animal	animal	NOUN
admet-1474	369	30	research	research	NOUN
admet-1474	369	31	,	,	PUNCT
admet-1474	369	32	2011	2011	NUM
admet-1474	369	33	.	.	PUNCT
admet-1474	370	1	http://www.nap.edu	http://www.nap.edu	PROPN
admet-1474	370	2	.	.	PUNCT
admet-1474	371	1	[	[	X
admet-1474	371	2	23	23	NUM
admet-1474	371	3	]	]	X
admet-1474	371	4	t.k	t.k	PROPN
admet-1474	371	5	.	.	PROPN
admet-1474	371	6	kim	kim	PROPN
admet-1474	371	7	,	,	PUNCT
admet-1474	371	8	w.	w.	PROPN
admet-1474	371	9	kang	kang	PROPN
admet-1474	371	10	,	,	PUNCT
admet-1474	371	11	i.k	i.k	PROPN
admet-1474	371	12	.	.	PROPN
admet-1474	371	13	chun	chun	PROPN
admet-1474	371	14	,	,	PUNCT
admet-1474	371	15	s.y	s.y	PROPN
admet-1474	371	16	.	.	PROPN
admet-1474	372	1	oh	oh	INTJ
admet-1474	372	2	,	,	PUNCT
admet-1474	372	3	y.h	y.h	PROPN
admet-1474	372	4	.	.	PROPN
admet-1474	372	5	lee	lee	PROPN
admet-1474	372	6	,	,	PUNCT
admet-1474	372	7	h.s	h.s	PROPN
admet-1474	372	8	.	.	PROPN
admet-1474	372	9	gwak	gwak	PROPN
admet-1474	372	10	.	.	PUNCT
admet-1474	373	1	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	373	2	evaluation	evaluation	NOUN
admet-1474	373	3	and	and	CCONJ
admet-1474	373	4	modeling	modeling	NOUN
admet-1474	373	5	of	of	ADP
admet-1474	373	6	formulated	formulate	VERB
admet-1474	373	7	levodopa	levodopa	NOUN
admet-1474	373	8	intranasal	intranasal	NOUN
admet-1474	373	9	delivery	delivery	NOUN
admet-1474	373	10	systems	system	NOUN
admet-1474	373	11	.	.	PUNCT
admet-1474	374	1	european	european	ADJ
admet-1474	374	2	journal	journal	PROPN
admet-1474	374	3	of	of	ADP
admet-1474	374	4	pharmaceutical	pharmaceutical	PROPN
admet-1474	374	5	sciences	science	NOUN
admet-1474	374	6	38	38	NUM
admet-1474	374	7	(	(	PUNCT
admet-1474	374	8	2009	2009	NUM
admet-1474	374	9	)	)	PUNCT
admet-1474	375	1	525–532	525–532	NUM
admet-1474	375	2	.	.	PUNCT
admet-1474	375	3	https://doi.org/10.1016/j.ejps.2009.09.019	https://doi.org/10.1016/j.ejps.2009.09.019	X
admet-1474	375	4	.	.	PUNCT
admet-1474	376	1	[	[	X
admet-1474	376	2	24	24	NUM
admet-1474	376	3	]	]	X
admet-1474	376	4	s.k	s.k	PROPN
admet-1474	376	5	.	.	PROPN
admet-1474	376	6	amponsah	amponsah	PROPN
admet-1474	376	7	,	,	PUNCT
admet-1474	376	8	s.	s.	PROPN
admet-1474	376	9	yeboah	yeboah	PROPN
admet-1474	376	10	,	,	PUNCT
admet-1474	376	11	k.k.e	k.k.e	NOUN
admet-1474	376	12	.	.	PUNCT
admet-1474	377	1	kukuia	kukuia	PROPN
admet-1474	377	2	,	,	PUNCT
admet-1474	377	3	b.b	b.b	PROPN
admet-1474	377	4	.	.	PUNCT
admet-1474	377	5	n’guessan	n’guessan	PROPN
admet-1474	377	6	,	,	PUNCT
admet-1474	377	7	o.	o.	PROPN
admet-1474	377	8	adi	adi	PROPN
admet-1474	377	9	-	-	PUNCT
admet-1474	377	10	dako	dako	PROPN
admet-1474	377	11	.	.	PUNCT
admet-1474	378	1	a	a	DET
admet-1474	378	2	pharmacokinetic	pharmacokinetic	ADJ
admet-1474	378	3	evaluation	evaluation	NOUN
admet-1474	378	4	of	of	ADP
admet-1474	378	5	a	a	DET
admet-1474	378	6	pectin	pectin	NOUN
admet-1474	378	7	-	-	PUNCT
admet-1474	378	8	based	base	VERB
admet-1474	378	9	oral	oral	ADJ
admet-1474	378	10	multiparticulate	multiparticulate	ADJ
admet-1474	378	11	matrix	matrix	NOUN
admet-1474	378	12	carrier	carrier	NOUN
admet-1474	378	13	of	of	ADP
admet-1474	378	14	carbamazepine	carbamazepine	NOUN
admet-1474	378	15	.	.	PUNCT
admet-1474	379	1	advances	advance	NOUN
admet-1474	379	2	in	in	ADP
admet-1474	379	3	pharmacological	pharmacological	NOUN
admet-1474	379	4	and	and	CCONJ
admet-1474	379	5	pharmaceutical	pharmaceutical	NOUN
admet-1474	379	6	sciences	science	NOUN
admet-1474	379	7	2021	2021	NUM
admet-1474	379	8	(	(	PUNCT
admet-1474	379	9	2021	2021	NUM
admet-1474	379	10	)	)	PUNCT
admet-1474	379	11	.	.	PUNCT
admet-1474	380	1	https://doi.org/10.1155/2021/5527452	https://doi.org/10.1155/2021/5527452	NOUN
admet-1474	380	2	.	.	PUNCT
admet-1474	381	1	[	[	X
admet-1474	381	2	25	25	NUM
admet-1474	381	3	]	]	PUNCT
admet-1474	381	4	c.	c.	PROPN
admet-1474	381	5	mollea	mollea	PROPN
admet-1474	381	6	,	,	PUNCT
admet-1474	381	7	f.	f.	PROPN
admet-1474	381	8	chiampo	chiampo	PROPN
admet-1474	381	9	,	,	PUNCT
admet-1474	381	10	r.	r.	PROPN
admet-1474	381	11	conti	conti	PROPN
admet-1474	381	12	.	.	PROPN
admet-1474	382	1	extraction	extraction	NOUN
admet-1474	382	2	and	and	CCONJ
admet-1474	382	3	characterization	characterization	NOUN
admet-1474	382	4	of	of	ADP
admet-1474	382	5	pectins	pectin	NOUN
admet-1474	382	6	from	from	ADP
admet-1474	382	7	cocoa	cocoa	NOUN
admet-1474	382	8	husks	husk	NOUN
admet-1474	382	9	:	:	PUNCT
admet-1474	382	10	a	a	DET
admet-1474	382	11	preliminary	preliminary	ADJ
admet-1474	382	12	study	study	NOUN
admet-1474	382	13	.	.	PUNCT
admet-1474	383	1	food	food	NOUN
admet-1474	383	2	chemistry	chemistry	NOUN
admet-1474	383	3	107	107	NUM
admet-1474	383	4	(	(	PUNCT
admet-1474	383	5	2008	2008	NUM
admet-1474	383	6	)	)	PUNCT
admet-1474	383	7	1353–1356	1353–1356	NUM
admet-1474	383	8	.	.	PUNCT
admet-1474	384	1	https://doi.org/10.1016/j.foodchem.2007.09.006	https://doi.org/10.1016/j.foodchem.2007.09.006	ADJ
admet-1474	384	2	.	.	PUNCT
admet-1474	385	1	[	[	X
admet-1474	385	2	26	26	NUM
admet-1474	385	3	]	]	X
admet-1474	385	4	m.a	m.a	PROPN
admet-1474	385	5	.	.	PROPN
admet-1474	385	6	sahari	sahari	PROPN
admet-1474	385	7	,	,	PUNCT
admet-1474	385	8	a.	a.	PROPN
admet-1474	385	9	akbarian	akbarian	PROPN
admet-1474	385	10	m	m	PROPN
admet-1474	385	11	,	,	PUNCT
admet-1474	385	12	m.	m.	PROPN
admet-1474	385	13	hamedi	hamedi	PROPN
admet-1474	385	14	.	.	PUNCT
admet-1474	385	15	effect	effect	NOUN
admet-1474	385	16	of	of	ADP
admet-1474	385	17	variety	variety	NOUN
admet-1474	385	18	and	and	CCONJ
admet-1474	385	19	acid	acid	NOUN
admet-1474	385	20	washing	washing	NOUN
admet-1474	385	21	method	method	NOUN
admet-1474	385	22	on	on	ADP
admet-1474	385	23	extraction	extraction	NOUN
admet-1474	385	24	yield	yield	NOUN
admet-1474	385	25	and	and	CCONJ
admet-1474	385	26	quality	quality	NOUN
admet-1474	385	27	of	of	ADP
admet-1474	385	28	sunflower	sunflower	NOUN
admet-1474	385	29	head	head	NOUN
admet-1474	385	30	pectin	pectin	NOUN
admet-1474	385	31	.	.	PUNCT
admet-1474	386	1	food	food	NOUN
admet-1474	386	2	chemistry	chemistry	NOUN
admet-1474	386	3	83	83	NUM
admet-1474	386	4	(	(	PUNCT
admet-1474	386	5	2003	2003	NUM
admet-1474	386	6	)	)	PUNCT
admet-1474	386	7	43–47	43–47	NOUN
admet-1474	386	8	.	.	PUNCT
admet-1474	386	9	https://doi.org/10.1016/s0308-8146(03)00034-7	https://doi.org/10.1016/s0308-8146(03)00034-7	NOUN
admet-1474	386	10	.	.	PUNCT
admet-1474	387	1	[	[	X
admet-1474	387	2	27	27	NUM
admet-1474	387	3	]	]	X
admet-1474	387	4	m.a	m.a	PROPN
admet-1474	387	5	.	.	PROPN
admet-1474	387	6	monsoor	monsoor	PROPN
admet-1474	387	7	,	,	PUNCT
admet-1474	387	8	u.	u.	PROPN
admet-1474	387	9	kalapathy	kalapathy	PROPN
admet-1474	387	10	,	,	PUNCT
admet-1474	387	11	a.	a.	NOUN
admet-1474	387	12	proctor	proctor	NOUN
admet-1474	387	13	.	.	PUNCT
admet-1474	388	1	determination	determination	NOUN
admet-1474	388	2	of	of	ADP
admet-1474	388	3	polygalacturonic	polygalacturonic	ADJ
admet-1474	388	4	acid	acid	NOUN
admet-1474	388	5	content	content	NOUN
admet-1474	388	6	in	in	ADP
admet-1474	388	7	pectin	pectin	NOUN
admet-1474	388	8	extracts	extract	NOUN
admet-1474	388	9	by	by	ADP
admet-1474	388	10	diffuse	diffuse	NOUN
admet-1474	388	11	reflectance	reflectance	NOUN
admet-1474	388	12	fourier	fourier	NOUN
admet-1474	388	13	transform	transform	VERB
admet-1474	388	14	infrared	infrared	ADJ
admet-1474	388	15	spectroscopy	spectroscopy	NOUN
admet-1474	388	16	.	.	PUNCT
admet-1474	389	1	food	food	NOUN
admet-1474	389	2	chemistry	chemistry	NOUN
admet-1474	389	3	74	74	NUM
admet-1474	389	4	(	(	PUNCT
admet-1474	389	5	2001	2001	NUM
admet-1474	389	6	)	)	PUNCT
admet-1474	390	1	233–238	233–238	NUM
admet-1474	390	2	.	.	PUNCT
admet-1474	391	1	https://doi.org/10.1016/s0308-8146(01)00100-5	https://doi.org/10.1016/s0308-8146(01)00100-5	PROPN
admet-1474	391	2	.	.	PUNCT
admet-1474	392	1	[	[	X
admet-1474	392	2	28	28	NUM
admet-1474	392	3	]	]	X
admet-1474	392	4	b.b	b.b	PROPN
admet-1474	392	5	.	.	PUNCT
admet-1474	393	1	n’guessan	n’guessan	PROPN
admet-1474	393	2	,	,	PUNCT
admet-1474	393	3	a.d	a.d	PROPN
admet-1474	393	4	.	.	PROPN
admet-1474	393	5	asiamah	asiamah	PROPN
admet-1474	393	6	,	,	PUNCT
admet-1474	393	7	n.k	n.k	PROPN
admet-1474	393	8	.	.	PROPN
admet-1474	393	9	arthur	arthur	PROPN
admet-1474	393	10	,	,	PUNCT
admet-1474	393	11	s.	s.	PROPN
admet-1474	393	12	frimpong	frimpong	PROPN
admet-1474	393	13	-	-	PUNCT
admet-1474	393	14	manso	manso	PROPN
admet-1474	393	15	,	,	PUNCT
admet-1474	393	16	p.	p.	PROPN
admet-1474	393	17	amoateng	amoateng	NOUN
admet-1474	393	18	,	,	PUNCT
admet-1474	393	19	s.k	s.k	PROPN
admet-1474	393	20	.	.	PROPN
admet-1474	393	21	amponsah	amponsah	PROPN
admet-1474	393	22	,	,	PUNCT
admet-1474	393	23	kukuia	kukuia	PROPN
admet-1474	393	24	k.	k.	PROPN
admet-1474	393	25	k.	k.	PROPN
admet-1474	394	1	e.	e.	PROPN
admet-1474	394	2	j.a	j.a	PROPN
admet-1474	394	3	.	.	PROPN
admet-1474	394	4	sarkodie	sarkodie	PROPN
admet-1474	394	5	,	,	PUNCT
admet-1474	394	6	k.f.m	k.f.m	PROPN
admet-1474	394	7	.	.	PROPN
admet-1474	394	8	opuni	opuni	PROPN
admet-1474	394	9	,	,	PUNCT
admet-1474	394	10	i.j	i.j	PROPN
admet-1474	394	11	.	.	PROPN
admet-1474	394	12	asiedu	asiedu	PROPN
admet-1474	394	13	-	-	PUNCT
admet-1474	394	14	gyekye	gyekye	PROPN
admet-1474	394	15	,	,	PUNCT
admet-1474	394	16	r.	r.	PROPN
admet-1474	394	17	appiah	appiah	PROPN
admet-1474	394	18	-	-	PUNCT
admet-1474	394	19	opong	opong	PROPN
admet-1474	394	20	.	.	PUNCT
admet-1474	395	1	ethanolic	ethanolic	ADJ
admet-1474	395	2	extract	extract	NOUN
admet-1474	395	3	of	of	ADP
admet-1474	395	4	nymphaea	nymphaea	PROPN
admet-1474	395	5	lotus	lotus	PROPN
admet-1474	395	6	l.	l.	PROPN
admet-1474	395	7	(	(	PUNCT
admet-1474	395	8	nymphaeaceae	nymphaeaceae	PROPN
admet-1474	395	9	)	)	PUNCT
admet-1474	395	10	leaves	leave	VERB
admet-1474	395	11	exhibits	exhibit	NOUN
admet-1474	395	12	in	in	ADP
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admet-1474	395	14	antioxidant	antioxidant	NOUN
admet-1474	395	15	,	,	PUNCT
admet-1474	395	16	in	in	ADP
admet-1474	395	17	vivo	vivo	ADJ
admet-1474	395	18	anti	anti	ADJ
admet-1474	395	19	-	-	ADJ
admet-1474	395	20	inflammatory	inflammatory	ADJ
admet-1474	395	21	and	and	CCONJ
admet-1474	395	22	cytotoxic	cytotoxic	ADJ
admet-1474	395	23	activities	activity	NOUN
admet-1474	395	24	on	on	ADP
admet-1474	395	25	jurkat	jurkat	PROPN
admet-1474	395	26	and	and	CCONJ
admet-1474	395	27	mcf-7	mcf-7	VERB
admet-1474	395	28	cancer	cancer	NOUN
admet-1474	395	29	cell	cell	NOUN
admet-1474	395	30	lines	line	NOUN
admet-1474	395	31	.	.	PUNCT
admet-1474	396	1	bmc	bmc	ADJ
admet-1474	396	2	complementary	complementary	ADJ
admet-1474	396	3	medicine	medicine	NOUN
admet-1474	396	4	and	and	CCONJ
admet-1474	396	5	therapies	therapy	NOUN
admet-1474	396	6	21	21	NUM
admet-1474	396	7	(	(	PUNCT
admet-1474	396	8	2021	2021	NUM
admet-1474	396	9	)	)	PUNCT
admet-1474	396	10	.	.	PUNCT
admet-1474	397	1	https://doi.org/10.1186/s12906-020-03195-w	https://doi.org/10.1186/s12906-020-03195-w	PROPN
admet-1474	397	2	.	.	PUNCT
admet-1474	398	1	[	[	X
admet-1474	398	2	29	29	NUM
admet-1474	398	3	]	]	PUNCT
admet-1474	398	4	l.	l.	PROPN
admet-1474	398	5	hennessey	hennessey	PROPN
admet-1474	398	6	-	-	PUNCT
admet-1474	398	7	ramos	ramos	PROPN
admet-1474	398	8	,	,	PUNCT
admet-1474	398	9	w.	w.	PROPN
admet-1474	398	10	murillo	murillo	PROPN
admet-1474	398	11	-	-	PUNCT
admet-1474	398	12	arango	arango	PROPN
admet-1474	398	13	,	,	PUNCT
admet-1474	398	14	j.	j.	PROPN
admet-1474	398	15	vasco	vasco	PROPN
admet-1474	398	16	-	-	PUNCT
admet-1474	398	17	correa	correa	PROPN
admet-1474	398	18	,	,	PUNCT
admet-1474	398	19	i.c.p	i.c.p	PROPN
admet-1474	398	20	.	.	PUNCT
admet-1474	398	21	astudillo	astudillo	PROPN
admet-1474	398	22	.	.	PUNCT
admet-1474	399	1	enzymatic	enzymatic	ADJ
admet-1474	399	2	extraction	extraction	NOUN
admet-1474	399	3	and	and	CCONJ
admet-1474	399	4	characterization	characterization	NOUN
admet-1474	399	5	of	of	ADP
admet-1474	399	6	pectin	pectin	NOUN
admet-1474	399	7	from	from	ADP
admet-1474	399	8	cocoa	cocoa	NOUN
admet-1474	399	9	pod	pod	NOUN
admet-1474	399	10	husks	husk	NOUN
admet-1474	399	11	(	(	PUNCT
admet-1474	399	12	theobroma	theobroma	NOUN
admet-1474	399	13	cacao	cacao	NOUN
admet-1474	399	14	l.	l.	PROPN
admet-1474	399	15	)	)	PUNCT
admet-1474	399	16	using	use	VERB
admet-1474	399	17	celluclast	celluclast	ADJ
admet-1474	399	18	®	®	NOUN
admet-1474	399	19	1.5	1.5	NUM
admet-1474	399	20	l.	l.	NOUN
admet-1474	399	21	molecules	molecule	NOUN
admet-1474	399	22	26	26	NUM
admet-1474	399	23	(	(	PUNCT
admet-1474	399	24	2021	2021	NUM
admet-1474	399	25	)	)	PUNCT
admet-1474	399	26	.	.	PUNCT
admet-1474	400	1	https://doi.org/10.3390/molecules26051473	https://doi.org/10.3390/molecules26051473	PROPN
admet-1474	400	2	.	.	PUNCT
admet-1474	401	1	[	[	X
admet-1474	401	2	30	30	NUM
admet-1474	401	3	]	]	X
admet-1474	401	4	y.k	y.k	PROPN
admet-1474	401	5	.	.	PROPN
admet-1474	401	6	sung	sung	PROPN
admet-1474	401	7	,	,	PUNCT
admet-1474	401	8	s.w	s.w	PROPN
admet-1474	401	9	.	.	PROPN
admet-1474	401	10	kim	kim	PROPN
admet-1474	401	11	.	.	PUNCT
admet-1474	402	1	recent	recent	ADJ
admet-1474	402	2	advances	advance	NOUN
admet-1474	402	3	in	in	ADP
admet-1474	402	4	polymeric	polymeric	ADJ
admet-1474	402	5	drug	drug	NOUN
admet-1474	402	6	delivery	delivery	NOUN
admet-1474	402	7	systems	system	NOUN
admet-1474	402	8	.	.	PUNCT
admet-1474	403	1	biomaterials	biomaterial	NOUN
admet-1474	403	2	research	research	VERB
admet-1474	403	3	24	24	NUM
admet-1474	403	4	(	(	PUNCT
admet-1474	403	5	2020	2020	NUM
admet-1474	403	6	)	)	PUNCT
admet-1474	403	7	.	.	PUNCT
admet-1474	404	1	https://doi.org/10.1186/s40824-020-00190-7	https://doi.org/10.1186/s40824-020-00190-7	NUM
admet-1474	404	2	.	.	PUNCT
admet-1474	405	1	[	[	X
admet-1474	405	2	31	31	NUM
admet-1474	405	3	]	]	PUNCT
admet-1474	405	4	s.	s.	PROPN
admet-1474	405	5	de	de	PROPN
admet-1474	405	6	robertis	robertis	PROPN
admet-1474	405	7	,	,	PUNCT
admet-1474	405	8	m.c	m.c	PROPN
admet-1474	405	9	.	.	PROPN
admet-1474	405	10	bonferoni	bonferoni	PROPN
admet-1474	405	11	,	,	PUNCT
admet-1474	405	12	l.	l.	PROPN
admet-1474	405	13	elviri	elviri	PROPN
admet-1474	405	14	,	,	PUNCT
admet-1474	405	15	g.	g.	PROPN
admet-1474	405	16	sandri	sandri	PROPN
admet-1474	405	17	,	,	PUNCT
admet-1474	405	18	c.	c.	PROPN
admet-1474	405	19	caramella	caramella	PROPN
admet-1474	405	20	,	,	PUNCT
admet-1474	405	21	r.	r.	PROPN
admet-1474	405	22	bettini	bettini	PROPN
admet-1474	405	23	.	.	PUNCT
admet-1474	406	1	advances	advance	NOUN
admet-1474	406	2	in	in	ADP
admet-1474	406	3	oral	oral	ADJ
admet-1474	406	4	controlled	control	VERB
admet-1474	406	5	drug	drug	NOUN
admet-1474	406	6	delivery	delivery	NOUN
admet-1474	406	7	:	:	PUNCT
admet-1474	406	8	the	the	DET
admet-1474	406	9	role	role	NOUN
admet-1474	406	10	of	of	ADP
admet-1474	406	11	drug	drug	NOUN
admet-1474	406	12	-	-	PUNCT
admet-1474	406	13	polymer	polymer	NOUN
admet-1474	406	14	and	and	CCONJ
admet-1474	406	15	interpolymer	interpolymer	ADJ
admet-1474	406	16	non	non	ADJ
admet-1474	406	17	-	-	ADJ
admet-1474	406	18	covalent	covalent	ADJ
admet-1474	406	19	interactions	interaction	NOUN
admet-1474	406	20	.	.	PUNCT
admet-1474	407	1	expert	expert	ADJ
admet-1474	407	2	opinion	opinion	NOUN
admet-1474	407	3	on	on	ADP
admet-1474	407	4	drug	drug	NOUN
admet-1474	407	5	delivery	delivery	NOUN
admet-1474	407	6	12	12	NUM
admet-1474	407	7	(	(	PUNCT
admet-1474	407	8	2015	2015	NUM
admet-1474	407	9	)	)	PUNCT
admet-1474	407	10	441–453	441–453	NUM
admet-1474	407	11	.	.	PUNCT
admet-1474	408	1	https://doi.org/10.1517/17425247.2015.966685	https://doi.org/10.1517/17425247.2015.966685	PROPN
admet-1474	408	2	.	.	PUNCT
admet-1474	409	1	[	[	X
admet-1474	409	2	32	32	NUM
admet-1474	409	3	]	]	X
admet-1474	409	4	n.	n.	PROPN
admet-1474	409	5	dey	dey	PROPN
admet-1474	409	6	,	,	PUNCT
admet-1474	409	7	s.	s.	PROPN
admet-1474	409	8	majumdar	majumdar	PROPN
admet-1474	409	9	,	,	PUNCT
admet-1474	409	10	m.	m.	PROPN
admet-1474	409	11	rao	rao	PROPN
admet-1474	409	12	.	.	PUNCT
admet-1474	410	1	multiparticulate	multiparticulate	ADJ
admet-1474	410	2	drug	drug	NOUN
admet-1474	410	3	delivery	delivery	NOUN
admet-1474	410	4	systems	system	NOUN
admet-1474	410	5	for	for	ADP
admet-1474	410	6	controlled	control	VERB
admet-1474	410	7	release	release	NOUN
admet-1474	410	8	.	.	PUNCT
admet-1474	411	1	tropical	tropical	ADJ
admet-1474	411	2	journal	journal	PROPN
admet-1474	411	3	of	of	ADP
admet-1474	411	4	pharmaceutical	pharmaceutical	ADJ
admet-1474	411	5	research	research	NOUN
admet-1474	411	6	7	7	NUM
admet-1474	411	7	(	(	PUNCT
admet-1474	411	8	2008	2008	NUM
admet-1474	411	9	)	)	PUNCT
admet-1474	411	10	1068	1068	NUM
admet-1474	411	11	-	-	SYM
admet-1474	411	12	1075	1075	NUM
admet-1474	411	13	.	.	PUNCT
admet-1474	412	1	https://doi.org/10.4314/tjpr.v7i3.14692	https://doi.org/10.4314/tjpr.v7i3.14692	PROPN
admet-1474	412	2	.	.	PROPN
admet-1474	412	3	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	412	4	https://doi.org/10.22159/ijap.2019v11i3.30676	https://doi.org/10.22159/ijap.2019v11i3.30676	X
admet-1474	412	5	https://doi.org/10.1208/s12249-013-9945-1	https://doi.org/10.1208/s12249-013-9945-1	NUM
admet-1474	413	1	https://doi.org/10.1208/s12249-013-9945-1	https://doi.org/10.1208/s12249-013-9945-1	NUM
admet-1474	413	2	https://doi.org/10.1097/md.0000000000023249	https://doi.org/10.1097/md.0000000000023249	PROPN
admet-1474	413	3	https://doi.org/10.1002/prp2.473	https://doi.org/10.1002/prp2.473	PROPN
admet-1474	413	4	http://www.nap.edu/	http://www.nap.edu/	PROPN
admet-1474	413	5	https://doi.org/10.1016/j.ejps.2009.09.019	https://doi.org/10.1016/j.ejps.2009.09.019	NUM
admet-1474	413	6	https://doi.org/10.1155/2021/5527452	https://doi.org/10.1155/2021/5527452	VERB
admet-1474	413	7	https://doi.org/10.1155/2021/5527452	https://doi.org/10.1155/2021/5527452	NOUN
admet-1474	413	8	https://doi.org/10.1016/j.foodchem.2007.09.006	https://doi.org/10.1016/j.foodchem.2007.09.006	ADJ
admet-1474	413	9	https://doi.org/10.1016/j.foodchem.2007.09.006	https://doi.org/10.1016/j.foodchem.2007.09.006	ADJ
admet-1474	413	10	https://doi.org/10.1016/s0308-8146(03)00034-7	https://doi.org/10.1016/s0308-8146(03)00034-7	NOUN
admet-1474	413	11	https://doi.org/10.1016/s0308-8146(03)00034-7	https://doi.org/10.1016/s0308-8146(03)00034-7	NOUN
admet-1474	413	12	https://doi.org/10.1016/s0308-8146(01)00100-5	https://doi.org/10.1016/s0308-8146(01)00100-5	PROPN
admet-1474	413	13	https://doi.org/10.1186/s12906-020-03195-w	https://doi.org/10.1186/s12906-020-03195-w	PROPN
admet-1474	413	14	https://doi.org/10.3390/molecules26051473	https://doi.org/10.3390/molecules26051473	VERB
admet-1474	413	15	https://doi.org/10.1186/s40824-020-00190-7	https://doi.org/10.1186/s40824-020-00190-7	PROPN
admet-1474	413	16	https://doi.org/10.1517/17425247.2015.966685	https://doi.org/10.1517/17425247.2015.966685	PROPN
admet-1474	413	17	https://doi.org/10.1517/17425247.2015.966685	https://doi.org/10.1517/17425247.2015.966685	PROPN
admet-1474	414	1	https://doi.org/10.4314/tjpr.v7i3.14692	https://doi.org/10.4314/tjpr.v7i3.14692	PROPN
admet-1474	414	2	https://doi.org/10.4314/tjpr.v7i3.14692	https://doi.org/10.4314/tjpr.v7i3.14692	PROPN
admet-1474	414	3	emelia	emelia	PROPN
admet-1474	414	4	priscilla	priscilla	PROPN
admet-1474	414	5	imbeah	imbeah	PROPN
admet-1474	414	6	et	et	PROPN
admet-1474	414	7	al	al	PROPN
admet-1474	414	8	.	.	PROPN
admet-1474	414	9	admet	admet	PROPN
admet-1474	414	10	&	&	CCONJ
admet-1474	414	11	dmpk	dmpk	PROPN
admet-1474	414	12	11(1	11(1	NUM
admet-1474	414	13	)	)	PUNCT
admet-1474	414	14	(	(	PUNCT
admet-1474	414	15	2023	2023	NUM
admet-1474	414	16	)	)	PUNCT
admet-1474	414	17	97	97	NUM
admet-1474	414	18	-	-	SYM
admet-1474	414	19	115	115	NUM
admet-1474	414	20	114	114	NUM
admet-1474	414	21	[	[	SYM
admet-1474	414	22	33	33	NUM
admet-1474	414	23	]	]	PUNCT
admet-1474	414	24	c.	c.	PROPN
admet-1474	414	25	schmidt	schmidt	PROPN
admet-1474	414	26	,	,	PUNCT
admet-1474	414	27	r.	r.	PROPN
admet-1474	414	28	bodmeier	bodmeier	PROPN
admet-1474	414	29	.	.	PUNCT
admet-1474	415	1	a	a	DET
admet-1474	415	2	multiparticulate	multiparticulate	ADJ
admet-1474	415	3	drug	drug	NOUN
admet-1474	415	4	-	-	PUNCT
admet-1474	415	5	delivery	delivery	NOUN
admet-1474	415	6	system	system	NOUN
admet-1474	415	7	based	base	VERB
admet-1474	415	8	on	on	ADP
admet-1474	415	9	pellets	pellet	NOUN
admet-1474	415	10	incorporated	incorporate	VERB
admet-1474	415	11	into	into	ADP
admet-1474	415	12	congealable	congealable	ADJ
admet-1474	415	13	polyethylene	polyethylene	NOUN
admet-1474	415	14	glycol	glycol	NOUN
admet-1474	415	15	carrier	carrier	NOUN
admet-1474	415	16	materials	material	NOUN
admet-1474	415	17	.	.	PUNCT
admet-1474	416	1	international	international	ADJ
admet-1474	416	2	journal	journal	PROPN
admet-1474	416	3	of	of	ADP
admet-1474	416	4	pharmaceutics	pharmaceutic	NOUN
admet-1474	416	5	216	216	NUM
admet-1474	416	6	(	(	PUNCT
admet-1474	416	7	2001	2001	NUM
admet-1474	416	8	)	)	PUNCT
admet-1474	416	9	9–16	9–16	NOUN
admet-1474	416	10	.	.	PUNCT
admet-1474	417	1	https://doi.org/10.1016/s0378-5173(00)00672-4	https://doi.org/10.1016/s0378-5173(00)00672-4	PROPN
admet-1474	417	2	.	.	PUNCT
admet-1474	418	1	[	[	X
admet-1474	418	2	34	34	NUM
admet-1474	418	3	]	]	X
admet-1474	418	4	r.k	r.k	PROPN
admet-1474	418	5	.	.	PROPN
admet-1474	418	6	verma	verma	PROPN
admet-1474	418	7	,	,	PUNCT
admet-1474	418	8	s.	s.	PROPN
admet-1474	418	9	garg	garg	PROPN
admet-1474	418	10	.	.	PUNCT
admet-1474	418	11	selection	selection	NOUN
admet-1474	418	12	of	of	ADP
admet-1474	418	13	excipients	excipient	NOUN
admet-1474	418	14	for	for	ADP
admet-1474	418	15	extended	extended	ADJ
admet-1474	418	16	release	release	NOUN
admet-1474	418	17	formulations	formulation	NOUN
admet-1474	418	18	of	of	ADP
admet-1474	418	19	glipizide	glipizide	NOUN
admet-1474	418	20	through	through	ADP
admet-1474	418	21	drug	drug	NOUN
admet-1474	418	22	-	-	PUNCT
admet-1474	418	23	excipient	excipient	NOUN
admet-1474	418	24	compatibility	compatibility	NOUN
admet-1474	418	25	testing	testing	NOUN
admet-1474	418	26	.	.	PUNCT
admet-1474	419	1	journal	journal	NOUN
admet-1474	419	2	of	of	ADP
admet-1474	419	3	pharmaceutical	pharmaceutical	NOUN
admet-1474	419	4	and	and	CCONJ
admet-1474	419	5	biomedical	biomedical	ADJ
admet-1474	419	6	analysis	analysis	NOUN
admet-1474	419	7	38	38	NUM
admet-1474	419	8	(	(	PUNCT
admet-1474	419	9	2005	2005	NUM
admet-1474	419	10	)	)	PUNCT
admet-1474	419	11	.	.	PUNCT
admet-1474	420	1	https://doi.org/10.1016/j.jpba.2005.02.026	https://doi.org/10.1016/j.jpba.2005.02.026	PROPN
admet-1474	420	2	.	.	PUNCT
admet-1474	421	1	[	[	X
admet-1474	421	2	35	35	NUM
admet-1474	421	3	]	]	X
admet-1474	421	4	a.i	a.i	PROPN
admet-1474	421	5	.	.	PROPN
admet-1474	421	6	segall	segall	PROPN
admet-1474	421	7	.	.	PUNCT
admet-1474	421	8	preformulation	preformulation	NOUN
admet-1474	421	9	:	:	PUNCT
admet-1474	421	10	the	the	DET
admet-1474	421	11	use	use	NOUN
admet-1474	421	12	of	of	ADP
admet-1474	421	13	ftir	ftir	NOUN
admet-1474	421	14	in	in	ADP
admet-1474	421	15	compatility	compatility	NOUN
admet-1474	421	16	studies	study	NOUN
admet-1474	421	17	.	.	PUNCT
admet-1474	422	1	journal	journal	PROPN
admet-1474	422	2	of	of	ADP
admet-1474	422	3	innovations	innovation	NOUN
admet-1474	422	4	in	in	ADP
admet-1474	422	5	applied	apply	VERB
admet-1474	422	6	pharmaceutical	pharmaceutical	ADJ
admet-1474	422	7	sciences	science	NOUN
admet-1474	422	8	4	4	NUM
admet-1474	422	9	(	(	PUNCT
admet-1474	422	10	2019	2019	NUM
admet-1474	422	11	)	)	PUNCT
admet-1474	422	12	1	1	NUM
admet-1474	422	13	-	-	SYM
admet-1474	422	14	6	6	NUM
admet-1474	422	15	.	.	PUNCT
admet-1474	423	1	[	[	X
admet-1474	423	2	36	36	NUM
admet-1474	423	3	]	]	X
admet-1474	423	4	v.s.	v.s.	PROPN
admet-1474	423	5	dave	dave	PROPN
admet-1474	423	6	,	,	PUNCT
admet-1474	423	7	r.	r.	PROPN
admet-1474	423	8	v	v	PROPN
admet-1474	423	9	haware	haware	PROPN
admet-1474	423	10	,	,	PUNCT
admet-1474	423	11	n.a	n.a	PROPN
admet-1474	423	12	.	.	PROPN
admet-1474	423	13	sangave	sangave	PROPN
admet-1474	423	14	,	,	PUNCT
admet-1474	423	15	m.	m.	NOUN
admet-1474	423	16	sayles	sayles	PROPN
admet-1474	423	17	,	,	PUNCT
admet-1474	423	18	m.	m.	NOUN
admet-1474	423	19	popielarczyk	popielarczyk	PROPN
admet-1474	423	20	.	.	PUNCT
admet-1474	423	21	drug	drug	NOUN
admet-1474	423	22	-	-	PUNCT
admet-1474	423	23	excipient	excipient	NOUN
admet-1474	423	24	compatibility	compatibility	NOUN
admet-1474	423	25	studies	study	NOUN
admet-1474	423	26	in	in	ADP
admet-1474	423	27	formulation	formulation	NOUN
admet-1474	423	28	development	development	NOUN
admet-1474	423	29	 	 	SPACE
admet-1474	423	30	:	:	PUNCT
admet-1474	423	31	current	current	ADJ
admet-1474	423	32	trends	trend	NOUN
admet-1474	423	33	and	and	CCONJ
admet-1474	423	34	techniques	technique	NOUN
admet-1474	423	35	.	.	PUNCT
admet-1474	424	1	american	american	PROPN
admet-1474	424	2	association	association	PROPN
admet-1474	424	3	of	of	ADP
admet-1474	424	4	pharmaceutical	pharmaceutical	ADJ
admet-1474	424	5	scientists	scientist	NOUN
admet-1474	424	6	1–2015	1–2015	INTJ
admet-1474	424	7	(	(	PUNCT
admet-1474	424	8	2015	2015	NUM
admet-1474	424	9	)	)	PUNCT
admet-1474	424	10	9–15	9–15	PROPN
admet-1474	424	11	.	.	PUNCT
admet-1474	425	1	[	[	X
admet-1474	425	2	37	37	NUM
admet-1474	425	3	]	]	X
admet-1474	425	4	i.	i.	PROPN
admet-1474	425	5	ledeti	ledeti	PROPN
admet-1474	425	6	,	,	PUNCT
admet-1474	425	7	s.	s.	PROPN
admet-1474	425	8	bolintineanu	bolintineanu	PROPN
admet-1474	425	9	,	,	PUNCT
admet-1474	425	10	g.	g.	PROPN
admet-1474	425	11	vlase	vlase	PROPN
admet-1474	425	12	,	,	PUNCT
admet-1474	425	13	d.	d.	PROPN
admet-1474	425	14	circioban	circioban	PROPN
admet-1474	425	15	,	,	PUNCT
admet-1474	425	16	a.	a.	PROPN
admet-1474	425	17	ledeti	ledeti	PROPN
admet-1474	425	18	,	,	PUNCT
admet-1474	425	19	t.	t.	NOUN
admet-1474	425	20	vlase	vlase	NOUN
admet-1474	425	21	,	,	PUNCT
admet-1474	425	22	l.m	l.m	PROPN
admet-1474	425	23	.	.	PROPN
admet-1474	425	24	suta	suta	PROPN
admet-1474	425	25	,	,	PUNCT
admet-1474	425	26	a.	a.	NOUN
admet-1474	425	27	caunii	caunii	PROPN
admet-1474	425	28	,	,	PUNCT
admet-1474	425	29	m.	m.	NOUN
admet-1474	425	30	murariu	murariu	NOUN
admet-1474	425	31	.	.	PUNCT
admet-1474	426	1	compatibility	compatibility	NOUN
admet-1474	426	2	study	study	NOUN
admet-1474	426	3	between	between	ADP
admet-1474	426	4	antiparkinsonian	antiparkinsonian	ADJ
admet-1474	426	5	drug	drug	NOUN
admet-1474	426	6	levodopa	levodopa	NOUN
admet-1474	426	7	and	and	CCONJ
admet-1474	426	8	excipients	excipient	NOUN
admet-1474	426	9	by	by	ADP
admet-1474	426	10	ftir	ftir	PROPN
admet-1474	426	11	spectroscopy	spectroscopy	PROPN
admet-1474	426	12	,	,	PUNCT
admet-1474	426	13	x	x	ADJ
admet-1474	426	14	-	-	NOUN
admet-1474	426	15	ray	ray	NOUN
admet-1474	426	16	diffraction	diffraction	NOUN
admet-1474	426	17	and	and	CCONJ
admet-1474	426	18	thermal	thermal	ADJ
admet-1474	426	19	analysis	analysis	NOUN
admet-1474	426	20	.	.	PUNCT
admet-1474	427	1	journal	journal	NOUN
admet-1474	427	2	of	of	ADP
admet-1474	427	3	thermal	thermal	ADJ
admet-1474	427	4	analysis	analysis	NOUN
admet-1474	427	5	and	and	CCONJ
admet-1474	427	6	calorimetry	calorimetry	NOUN
admet-1474	427	7	130	130	NUM
admet-1474	427	8	(	(	PUNCT
admet-1474	427	9	2017	2017	NUM
admet-1474	427	10	)	)	PUNCT
admet-1474	427	11	433	433	NUM
admet-1474	427	12	–	–	PUNCT
admet-1474	427	13	441	441	NUM
admet-1474	427	14	.	.	PUNCT
admet-1474	427	15	https://doi.org/10.1007/s10973-017-6393-2	https://doi.org/10.1007/s10973-017-6393-2	NUM
admet-1474	427	16	.	.	PUNCT
admet-1474	428	1	[	[	X
admet-1474	428	2	38	38	NUM
admet-1474	428	3	]	]	PUNCT
admet-1474	428	4	h.	h.	PROPN
admet-1474	428	5	bukhary	bukhary	PROPN
admet-1474	428	6	,	,	PUNCT
admet-1474	428	7	g.r	g.r	PROPN
admet-1474	428	8	.	.	PROPN
admet-1474	428	9	williams	williams	PROPN
admet-1474	428	10	,	,	PUNCT
admet-1474	428	11	m.	m.	NOUN
admet-1474	428	12	orlu	orlu	NOUN
admet-1474	428	13	.	.	PUNCT
admet-1474	429	1	fabrication	fabrication	NOUN
admet-1474	429	2	of	of	ADP
admet-1474	429	3	electrospun	electrospun	NOUN
admet-1474	429	4	levodopa	levodopa	NOUN
admet-1474	429	5	-	-	PUNCT
admet-1474	429	6	carbidopa	carbidopa	NOUN
admet-1474	429	7	fixed	fix	VERB
admet-1474	429	8	-	-	PUNCT
admet-1474	429	9	dose	dose	NOUN
admet-1474	429	10	combinations	combination	NOUN
admet-1474	429	11	.	.	PUNCT
admet-1474	430	1	advanced	advanced	ADJ
admet-1474	430	2	fiber	fiber	NOUN
admet-1474	430	3	materials	material	NOUN
admet-1474	430	4	2	2	NUM
admet-1474	430	5	(	(	PUNCT
admet-1474	430	6	2020	2020	NUM
admet-1474	430	7	)	)	PUNCT
admet-1474	430	8	194–203	194–203	NUM
admet-1474	430	9	.	.	PUNCT
admet-1474	431	1	https://doi.org/10.1007/s42765-02000031-1	https://doi.org/10.1007/s42765-02000031-1	NOUN
admet-1474	431	2	.	.	PUNCT
admet-1474	432	1	[	[	X
admet-1474	432	2	39	39	NUM
admet-1474	432	3	]	]	PUNCT
admet-1474	432	4	f.	f.	PROPN
admet-1474	432	5	bigucci	bigucci	PROPN
admet-1474	432	6	,	,	PUNCT
admet-1474	432	7	b.	b.	PROPN
admet-1474	432	8	luppi	luppi	PROPN
admet-1474	432	9	,	,	PUNCT
admet-1474	432	10	t.	t.	PROPN
admet-1474	432	11	cerchiara	cerchiara	PROPN
admet-1474	432	12	,	,	PUNCT
admet-1474	432	13	m.	m.	NOUN
admet-1474	432	14	sorrenti	sorrenti	PROPN
admet-1474	432	15	,	,	PUNCT
admet-1474	432	16	g.	g.	PROPN
admet-1474	432	17	bettinetti	bettinetti	PROPN
admet-1474	432	18	,	,	PUNCT
admet-1474	432	19	l.	l.	PROPN
admet-1474	432	20	rodriguez	rodriguez	PROPN
admet-1474	432	21	,	,	PUNCT
admet-1474	432	22	v.	v.	PROPN
admet-1474	432	23	zecchi	zecchi	PROPN
admet-1474	432	24	.	.	PUNCT
admet-1474	433	1	chitosan	chitosan	NOUN
admet-1474	433	2	/	/	SYM
admet-1474	433	3	pectin	pectin	NOUN
admet-1474	433	4	polyelectrolyte	polyelectrolyte	NOUN
admet-1474	433	5	complexes	complex	NOUN
admet-1474	433	6	:	:	PUNCT
admet-1474	433	7	selection	selection	NOUN
admet-1474	433	8	of	of	ADP
admet-1474	433	9	suitable	suitable	ADJ
admet-1474	433	10	preparative	preparative	ADJ
admet-1474	433	11	conditions	condition	NOUN
admet-1474	433	12	for	for	ADP
admet-1474	433	13	colon	colon	NOUN
admet-1474	433	14	-	-	PUNCT
admet-1474	433	15	specific	specific	ADJ
admet-1474	433	16	delivery	delivery	NOUN
admet-1474	433	17	of	of	ADP
admet-1474	433	18	vancomycin	vancomycin	PROPN
admet-1474	433	19	.	.	PUNCT
admet-1474	434	1	european	european	PROPN
admet-1474	434	2	journal	journal	PROPN
admet-1474	434	3	of	of	ADP
admet-1474	434	4	pharmaceutical	pharmaceutical	PROPN
admet-1474	434	5	sciences	science	NOUN
admet-1474	434	6	35	35	NUM
admet-1474	434	7	(	(	PUNCT
admet-1474	434	8	2008	2008	NUM
admet-1474	434	9	)	)	PUNCT
admet-1474	435	1	435–441	435–441	NUM
admet-1474	435	2	.	.	PUNCT
admet-1474	435	3	https://doi.org/10.1016/j.ejps.2008.09.004	https://doi.org/10.1016/j.ejps.2008.09.004	PROPN
admet-1474	435	4	.	.	PUNCT
admet-1474	436	1	[	[	X
admet-1474	436	2	40	40	NUM
admet-1474	436	3	]	]	X
admet-1474	436	4	h.h	h.h	PROPN
admet-1474	436	5	.	.	PROPN
admet-1474	436	6	gadalla	gadalla	PROPN
admet-1474	436	7	,	,	PUNCT
admet-1474	436	8	g.m	g.m	PROPN
admet-1474	436	9	.	.	PROPN
admet-1474	436	10	soliman	soliman	PROPN
admet-1474	436	11	,	,	PUNCT
admet-1474	436	12	f.a	f.a	PROPN
admet-1474	436	13	.	.	PROPN
admet-1474	436	14	mohammed	mohammed	PROPN
admet-1474	436	15	,	,	PUNCT
admet-1474	436	16	a.m.	a.m.	PROPN
admet-1474	437	1	el	el	PROPN
admet-1474	437	2	-	-	PUNCT
admet-1474	437	3	sayed	say	VERB
admet-1474	437	4	.	.	PUNCT
admet-1474	438	1	development	development	NOUN
admet-1474	438	2	and	and	CCONJ
admet-1474	438	3	in	in	ADP
admet-1474	438	4	vitro	vitro	X
admet-1474	438	5	/	/	SYM
admet-1474	438	6	in	in	ADP
admet-1474	438	7	vivo	vivo	ADJ
admet-1474	438	8	evaluation	evaluation	NOUN
admet-1474	438	9	of	of	ADP
admet-1474	438	10	zn	zn	PROPN
admet-1474	438	11	-	-	PUNCT
admet-1474	438	12	pectinate	pectinate	NOUN
admet-1474	438	13	microparticles	microparticle	NOUN
admet-1474	438	14	reinforced	reinforce	VERB
admet-1474	438	15	with	with	ADP
admet-1474	438	16	chitosan	chitosan	NOUN
admet-1474	438	17	for	for	ADP
admet-1474	438	18	the	the	DET
admet-1474	438	19	colonic	colonic	ADJ
admet-1474	438	20	delivery	delivery	NOUN
admet-1474	438	21	of	of	ADP
admet-1474	438	22	progesterone	progesterone	NOUN
admet-1474	438	23	.	.	PUNCT
admet-1474	439	1	drug	drug	NOUN
admet-1474	439	2	delivery	delivery	NOUN
admet-1474	439	3	23	23	NUM
admet-1474	439	4	(	(	PUNCT
admet-1474	439	5	2016	2016	NUM
admet-1474	439	6	)	)	PUNCT
admet-1474	439	7	2541–2554	2541–2554	NUM
admet-1474	439	8	.	.	PUNCT
admet-1474	440	1	https://doi.org/10.3109/10717544.2015.1028602	https://doi.org/10.3109/10717544.2015.1028602	X
admet-1474	440	2	.	.	PUNCT
admet-1474	441	1	[	[	X
admet-1474	441	2	41	41	NUM
admet-1474	441	3	]	]	X
admet-1474	441	4	o.	o.	PROPN
admet-1474	441	5	adi	adi	PROPN
admet-1474	441	6	-	-	PUNCT
admet-1474	441	7	dako	dako	PROPN
admet-1474	441	8	,	,	PUNCT
admet-1474	441	9	d.	d.	PROPN
admet-1474	441	10	kumadoh	kumadoh	PROPN
admet-1474	441	11	,	,	PUNCT
admet-1474	441	12	g.	g.	PROPN
admet-1474	441	13	egbi	egbi	PROPN
admet-1474	441	14	,	,	PUNCT
admet-1474	441	15	s.	s.	PROPN
admet-1474	441	16	okyem	okyem	PROPN
admet-1474	441	17	,	,	PUNCT
admet-1474	441	18	p.y	p.y	PROPN
admet-1474	441	19	.	.	PROPN
admet-1474	441	20	addo	addo	PROPN
admet-1474	441	21	,	,	PUNCT
admet-1474	441	22	a.	a.	NOUN
admet-1474	441	23	nyarko	nyarko	PROPN
admet-1474	441	24	,	,	PUNCT
admet-1474	441	25	c.	c.	PROPN
admet-1474	441	26	osei	osei	PROPN
admet-1474	441	27	-	-	PUNCT
admet-1474	441	28	asare	asare	PROPN
admet-1474	441	29	,	,	PUNCT
admet-1474	441	30	e.e	e.e	PROPN
admet-1474	441	31	.	.	PROPN
admet-1474	441	32	oppong	oppong	PROPN
admet-1474	441	33	,	,	PUNCT
admet-1474	441	34	e.	e.	PROPN
admet-1474	441	35	adase	adase	PROPN
admet-1474	441	36	.	.	PUNCT
admet-1474	442	1	strategies	strategy	NOUN
admet-1474	442	2	for	for	ADP
admet-1474	442	3	formulation	formulation	NOUN
admet-1474	442	4	of	of	ADP
admet-1474	442	5	effervescent	effervescent	ADJ
admet-1474	442	6	granules	granule	NOUN
admet-1474	442	7	of	of	ADP
admet-1474	442	8	an	an	DET
admet-1474	442	9	herbal	herbal	ADJ
admet-1474	442	10	product	product	NOUN
admet-1474	442	11	for	for	ADP
admet-1474	442	12	the	the	DET
admet-1474	442	13	management	management	NOUN
admet-1474	442	14	of	of	ADP
admet-1474	442	15	typhoid	typhoid	NOUN
admet-1474	442	16	fever	fever	NOUN
admet-1474	442	17	.	.	PUNCT
admet-1474	443	1	heliyon	heliyon	NOUN
admet-1474	443	2	7	7	NUM
admet-1474	443	3	(	(	PUNCT
admet-1474	443	4	2021	2021	NUM
admet-1474	443	5	)	)	PUNCT
admet-1474	443	6	e08147	e08147	NOUN
admet-1474	443	7	.	.	PUNCT
admet-1474	444	1	https://doi.org/10.1016/j.heliyon.2021.e08147	https://doi.org/10.1016/j.heliyon.2021.e08147	PROPN
admet-1474	444	2	.	.	PUNCT
admet-1474	445	1	[	[	X
admet-1474	445	2	42	42	NUM
admet-1474	445	3	]	]	X
admet-1474	445	4	g.	g.	PROPN
admet-1474	445	5	alderborn	alderborn	PROPN
admet-1474	445	6	,	,	PUNCT
admet-1474	445	7	g.	g.	PROPN
admet-1474	445	8	frenning	frenning	NOUN
admet-1474	445	9	.	.	PUNCT
admet-1474	446	1	tablets	tablet	NOUN
admet-1474	446	2	and	and	CCONJ
admet-1474	446	3	compaction	compaction	NOUN
admet-1474	446	4	.	.	PUNCT
admet-1474	447	1	aulton	aulton	PROPN
admet-1474	447	2	’s	’s	PART
admet-1474	447	3	pharmaceutics	pharmaceutic	NOUN
admet-1474	447	4	:	:	PUNCT
admet-1474	447	5	the	the	DET
admet-1474	447	6	design	design	NOUN
admet-1474	447	7	and	and	CCONJ
admet-1474	447	8	manufacture	manufacture	NOUN
admet-1474	447	9	of	of	ADP
admet-1474	447	10	medicines	medicine	NOUN
admet-1474	447	11	(	(	PUNCT
admet-1474	447	12	2021	2021	NUM
admet-1474	447	13	)	)	PUNCT
admet-1474	447	14	501–542	501–542	NUM
admet-1474	447	15	.	.	PUNCT
admet-1474	448	1	[	[	X
admet-1474	448	2	43	43	NUM
admet-1474	448	3	]	]	X
admet-1474	448	4	m.	m.	NOUN
admet-1474	448	5	balaji	balaji	PROPN
admet-1474	448	6	,	,	PUNCT
admet-1474	448	7	n.	n.	PROPN
admet-1474	448	8	ramyakrishna	ramyakrishna	NOUN
admet-1474	448	9	,	,	PUNCT
admet-1474	448	10	m.	m.	NOUN
admet-1474	448	11	hanumanaik	hanumanaik	PROPN
admet-1474	448	12	.	.	PUNCT
admet-1474	449	1	formulation	formulation	NOUN
admet-1474	449	2	development	development	NOUN
admet-1474	449	3	and	and	CCONJ
admet-1474	449	4	characterization	characterization	NOUN
admet-1474	449	5	of	of	ADP
admet-1474	449	6	enteric	enteric	ADJ
admet-1474	449	7	coated	coated	ADJ
admet-1474	449	8	tablets	tablet	NOUN
admet-1474	449	9	of	of	ADP
admet-1474	449	10	lansoprazole	lansoprazole	NOUN
admet-1474	449	11	.	.	PUNCT
admet-1474	450	1	der	der	ADJ
admet-1474	450	2	pharmacia	pharmacia	PROPN
admet-1474	450	3	lettre	lettre	PROPN
admet-1474	450	4	12	12	NUM
admet-1474	450	5	(	(	PUNCT
admet-1474	450	6	2020	2020	NUM
admet-1474	450	7	)	)	PUNCT
admet-1474	450	8	22–38	22–38	NUM
admet-1474	450	9	.	.	PUNCT
admet-1474	450	10	www.scholarsresearchlibrary.com	www.scholarsresearchlibrary.com	X
admet-1474	450	11	.	.	PUNCT
admet-1474	451	1	[	[	X
admet-1474	451	2	44	44	NUM
admet-1474	451	3	]	]	PUNCT
admet-1474	451	4	us	us	PROPN
admet-1474	451	5	pharmacopeia	pharmacopeia	PROPN
admet-1474	451	6	national	national	PROPN
admet-1474	451	7	formulary	formulary	PROPN
admet-1474	451	8	(	(	PUNCT
admet-1474	451	9	usp	usp	NOUN
admet-1474	451	10	-	-	PUNCT
admet-1474	451	11	nf	nf	NOUN
admet-1474	451	12	)	)	PUNCT
admet-1474	451	13	(	(	PUNCT
admet-1474	451	14	2021	2021	NUM
admet-1474	451	15	)	)	PUNCT
admet-1474	451	16	.	.	PUNCT
admet-1474	452	1	in	in	ADP
admet-1474	452	2	united	united	PROPN
admet-1474	452	3	states	states	PROPN
admet-1474	452	4	pharmacopeia	pharmacopeia	PROPN
admet-1474	452	5	convention	convention	PROPN
admet-1474	452	6	committee	committee	PROPN
admet-1474	452	7	of	of	ADP
admet-1474	452	8	revision	revision	NOUN
admet-1474	452	9	(	(	PUNCT
admet-1474	452	10	ed	ed	NOUN
admet-1474	452	11	.	.	PUNCT
admet-1474	452	12	)	)	PUNCT
admet-1474	452	13	,	,	PUNCT
admet-1474	452	14	united	united	PROPN
admet-1474	452	15	states	states	PROPN
admet-1474	452	16	pharmacopeia	pharmacopeia	PROPN
admet-1474	452	17	national	national	PROPN
admet-1474	452	18	formulary	formulary	NOUN
admet-1474	452	19	(	(	PUNCT
admet-1474	452	20	43rd	43rd	ADJ
admet-1474	452	21	ed	ed	NOUN
admet-1474	452	22	.	.	PUNCT
admet-1474	452	23	,	,	PUNCT
admet-1474	452	24	p.	p.	NOUN
admet-1474	452	25	8)	8)	NUM
admet-1474	452	26	.	.	PUNCT
admet-1474	453	1	[	[	X
admet-1474	453	2	45	45	NUM
admet-1474	453	3	]	]	PUNCT
admet-1474	453	4	i.	i.	PROPN
admet-1474	453	5	el	el	PROPN
admet-1474	453	6	-	-	PROPN
admet-1474	453	7	gibaly	gibaly	NOUN
admet-1474	453	8	.	.	PUNCT
admet-1474	453	9	oral	oral	ADJ
admet-1474	453	10	delayed	delay	VERB
admet-1474	453	11	-	-	PUNCT
admet-1474	453	12	release	release	NOUN
admet-1474	453	13	system	system	NOUN
admet-1474	453	14	based	base	VERB
admet-1474	453	15	on	on	ADP
admet-1474	453	16	zn	zn	PROPN
admet-1474	453	17	-	-	PUNCT
admet-1474	453	18	pectinate	pectinate	NOUN
admet-1474	453	19	gel	gel	NOUN
admet-1474	453	20	(	(	PUNCT
admet-1474	453	21	zpg	zpg	NOUN
admet-1474	453	22	)	)	PUNCT
admet-1474	453	23	microparticles	microparticle	NOUN
admet-1474	453	24	as	as	ADP
admet-1474	453	25	an	an	DET
admet-1474	453	26	alternative	alternative	ADJ
admet-1474	453	27	carrier	carrier	NOUN
admet-1474	453	28	to	to	ADP
admet-1474	453	29	calcium	calcium	NOUN
admet-1474	453	30	pectinate	pectinate	NOUN
admet-1474	453	31	beads	bead	NOUN
admet-1474	453	32	for	for	ADP
admet-1474	453	33	colonic	colonic	ADJ
admet-1474	453	34	drug	drug	NOUN
admet-1474	453	35	delivery	delivery	NOUN
admet-1474	453	36	.	.	PUNCT
admet-1474	454	1	international	international	ADJ
admet-1474	454	2	journal	journal	PROPN
admet-1474	454	3	of	of	ADP
admet-1474	454	4	pharmaceutics	pharmaceutic	NOUN
admet-1474	454	5	232	232	NUM
admet-1474	454	6	(	(	PUNCT
admet-1474	454	7	2002	2002	NUM
admet-1474	454	8	)	)	PUNCT
admet-1474	455	1	199–211	199–211	NUM
admet-1474	455	2	.	.	PUNCT
admet-1474	456	1	https://doi.org/10.1016/s0378-5173(01)00903-6	https://doi.org/10.1016/s0378-5173(01)00903-6	PROPN
admet-1474	456	2	.	.	PUNCT
admet-1474	457	1	[	[	X
admet-1474	457	2	46	46	NUM
admet-1474	457	3	]	]	PUNCT
admet-1474	457	4	b.	b.	PROPN
admet-1474	457	5	wu	wu	PROPN
admet-1474	457	6	,	,	PUNCT
admet-1474	457	7	z.	z.	PROPN
admet-1474	457	8	chen	chen	PROPN
admet-1474	457	9	,	,	PUNCT
admet-1474	457	10	x.	x.	PROPN
admet-1474	457	11	wei	wei	PROPN
admet-1474	457	12	,	,	PUNCT
admet-1474	457	13	n.	n.	PROPN
admet-1474	457	14	sun	sun	PROPN
admet-1474	457	15	,	,	PUNCT
admet-1474	457	16	y.	y.	PROPN
admet-1474	457	17	lu	lu	PROPN
admet-1474	457	18	,	,	PUNCT
admet-1474	457	19	w.	w.	PROPN
admet-1474	457	20	wu	wu	PROPN
admet-1474	457	21	.	.	PUNCT
admet-1474	458	1	biphasic	biphasic	ADJ
admet-1474	458	2	release	release	NOUN
admet-1474	458	3	of	of	ADP
admet-1474	458	4	indomethacin	indomethacin	NOUN
admet-1474	458	5	from	from	ADP
admet-1474	458	6	hpmc	hpmc	ADJ
admet-1474	458	7	/	/	SYM
admet-1474	458	8	pectin	pectin	NOUN
admet-1474	458	9	/	/	SYM
admet-1474	458	10	calcium	calcium	NOUN
admet-1474	458	11	matrix	matrix	NOUN
admet-1474	458	12	tablet	tablet	NOUN
admet-1474	458	13	:	:	PUNCT
admet-1474	458	14	i.	i.	NOUN
admet-1474	458	15	characterization	characterization	NOUN
admet-1474	458	16	and	and	CCONJ
admet-1474	458	17	mechanistic	mechanistic	ADJ
admet-1474	458	18	study	study	NOUN
admet-1474	458	19	.	.	PUNCT
admet-1474	459	1	european	european	PROPN
admet-1474	459	2	journal	journal	PROPN
admet-1474	459	3	of	of	ADP
admet-1474	459	4	pharmaceutics	pharmaceutic	NOUN
admet-1474	459	5	and	and	CCONJ
admet-1474	459	6	biopharmaceutics	biopharmaceutic	NOUN
admet-1474	459	7	67	67	NUM
admet-1474	459	8	(	(	PUNCT
admet-1474	459	9	2007	2007	NUM
admet-1474	459	10	)	)	PUNCT
admet-1474	460	1	707–714	707–714	NUM
admet-1474	460	2	.	.	PUNCT
admet-1474	461	1	https://doi.org/10.1016/j.ejpb.2007.04.016	https://doi.org/10.1016/j.ejpb.2007.04.016	NUM
admet-1474	461	2	.	.	PUNCT
admet-1474	462	1	[	[	X
admet-1474	462	2	47	47	NUM
admet-1474	462	3	]	]	X
admet-1474	462	4	o.	o.	PROPN
admet-1474	462	5	adi	adi	PROPN
admet-1474	462	6	-	-	PUNCT
admet-1474	462	7	dako	dako	PROPN
admet-1474	462	8	,	,	PUNCT
admet-1474	462	9	k.	k.	PROPN
admet-1474	462	10	ofori	ofori	PROPN
admet-1474	462	11	-	-	PUNCT
admet-1474	462	12	kwakye	kwakye	ADJ
admet-1474	462	13	,	,	PUNCT
admet-1474	462	14	s.k	s.k	PROPN
admet-1474	462	15	.	.	PROPN
admet-1474	462	16	amponsah	amponsah	PROPN
admet-1474	462	17	,	,	PUNCT
admet-1474	462	18	i.	i.	PROPN
admet-1474	462	19	boamah	boamah	PROPN
admet-1474	462	20	,	,	PUNCT
admet-1474	462	21	n.	n.	PROPN
admet-1474	462	22	kuntworbe	kuntworbe	PROPN
admet-1474	462	23	,	,	PUNCT
admet-1474	462	24	e.e	e.e	PROPN
admet-1474	462	25	.	.	PROPN
admet-1474	462	26	oppong	oppong	PROPN
admet-1474	462	27	.	.	PUNCT
admet-1474	463	1	potential	potential	NOUN
admet-1474	463	2	of	of	ADP
admet-1474	463	3	cocoa	cocoa	PROPN
admet-1474	463	4	pod	pod	PROPN
admet-1474	463	5	husk	husk	PROPN
admet-1474	463	6	pectin	pectin	NOUN
admet-1474	463	7	-	-	PUNCT
admet-1474	463	8	based	base	VERB
admet-1474	463	9	modified	modify	VERB
admet-1474	463	10	release	release	NOUN
admet-1474	463	11	capsules	capsule	NOUN
admet-1474	463	12	as	as	ADP
admet-1474	463	13	a	a	DET
admet-1474	463	14	carrier	carrier	NOUN
admet-1474	463	15	for	for	ADP
admet-1474	463	16	chronodelivery	chronodelivery	NOUN
admet-1474	463	17	of	of	ADP
admet-1474	463	18	hydrocortisone	hydrocortisone	PROPN
admet-1474	463	19	in	in	ADP
admet-1474	463	20	sprague	sprague	NOUN
admet-1474	463	21	-	-	PUNCT
admet-1474	463	22	dawley	dawley	NOUN
admet-1474	463	23	rats	rat	NOUN
admet-1474	463	24	.	.	PUNCT
admet-1474	464	1	journal	journal	NOUN
admet-1474	464	2	of	of	ADP
admet-1474	464	3	drug	drug	NOUN
admet-1474	464	4	delivery	delivery	NOUN
admet-1474	464	5	2018	2018	NUM
admet-1474	464	6	(	(	PUNCT
admet-1474	464	7	2018	2018	NUM
admet-1474	464	8	)	)	PUNCT
admet-1474	464	9	1–8	1–8	X
admet-1474	464	10	.	.	PUNCT
admet-1474	464	11	https://doi.org/10.1155/2018/9825363	https://doi.org/10.1155/2018/9825363	PROPN
admet-1474	464	12	.	.	PUNCT
admet-1474	465	1	[	[	X
admet-1474	465	2	48	48	NUM
admet-1474	465	3	]	]	X
admet-1474	465	4	v.	v.	CCONJ
admet-1474	465	5	pandit	pandit	PROPN
admet-1474	465	6	,	,	PUNCT
admet-1474	465	7	s.	s.	PROPN
admet-1474	465	8	suresh	suresh	PROPN
admet-1474	465	9	,	,	PUNCT
admet-1474	465	10	h.	h.	PROPN
admet-1474	465	11	joshi	joshi	PROPN
admet-1474	465	12	.	.	PUNCT
admet-1474	466	1	gastroretentive	gastroretentive	ADJ
admet-1474	466	2	drug	drug	NOUN
admet-1474	466	3	delivery	delivery	NOUN
admet-1474	466	4	system	system	NOUN
admet-1474	466	5	of	of	ADP
admet-1474	466	6	amoxycillin	amoxycillin	NOUN
admet-1474	466	7	:	:	PUNCT
admet-1474	466	8	formulation	formulation	NOUN
admet-1474	466	9	and	and	CCONJ
admet-1474	466	10	in	in	ADP
admet-1474	466	11	vitro	vitro	X
admet-1474	466	12	evaluation	evaluation	NOUN
admet-1474	466	13	.	.	PUNCT
admet-1474	467	1	international	international	ADJ
admet-1474	467	2	journal	journal	PROPN
admet-1474	467	3	of	of	ADP
admet-1474	467	4	pharma	pharma	PROPN
admet-1474	467	5	and	and	CCONJ
admet-1474	467	6	bio	bio	PROPN
admet-1474	467	7	sciences	sciences	PROPN
admet-1474	467	8	1	1	NUM
admet-1474	467	9	(	(	PUNCT
admet-1474	467	10	2010	2010	NUM
admet-1474	467	11	)	)	PUNCT
admet-1474	467	12	1	1	NUM
admet-1474	467	13	-	-	SYM
admet-1474	467	14	7	7	NUM
admet-1474	467	15	.	.	PUNCT
admet-1474	467	16	https://doi.org/10.1016/s0378-5173(00)00672-4	https://doi.org/10.1016/s0378-5173(00)00672-4	VERB
admet-1474	467	17	https://doi.org/10.1016/j.jpba.2005.02.026	https://doi.org/10.1016/j.jpba.2005.02.026	PROPN
admet-1474	467	18	https://doi.org/10.1007/s10973-017-6393-2	https://doi.org/10.1007/s10973-017-6393-2	NUM
admet-1474	467	19	https://doi.org/10.1007/s42765-020-00031-1	https://doi.org/10.1007/s42765-020-00031-1	NUM
admet-1474	467	20	https://doi.org/10.1007/s42765-020-00031-1	https://doi.org/10.1007/s42765-020-00031-1	NUM
admet-1474	467	21	https://doi.org/10.1016/j.ejps.2008.09.004	https://doi.org/10.1016/j.ejps.2008.09.004	NOUN
admet-1474	467	22	https://doi.org/10.3109/10717544.2015.1028602	https://doi.org/10.3109/10717544.2015.1028602	PUNCT
admet-1474	467	23	https://doi.org/10.3109/10717544.2015.1028602	https://doi.org/10.3109/10717544.2015.1028602	PRON
admet-1474	467	24	https://doi.org/10.1016/j.heliyon.2021.e08147	https://doi.org/10.1016/j.heliyon.2021.e08147	PROPN
admet-1474	467	25	https://doi.org/10.1016/j.heliyon.2021.e08147	https://doi.org/10.1016/j.heliyon.2021.e08147	NOUN
admet-1474	467	26	http://www.scholarsresearchlibrary.com/	http://www.scholarsresearchlibrary.com/	NOUN
admet-1474	467	27	https://doi.org/10.1016/s0378-5173(01)00903-6	https://doi.org/10.1016/s0378-5173(01)00903-6	VERB
admet-1474	468	1	https://doi.org/10.1016/j.ejpb.2007.04.016	https://doi.org/10.1016/j.ejpb.2007.04.016	PROPN
admet-1474	468	2	https://doi.org/10.1016/j.ejpb.2007.04.016	https://doi.org/10.1016/j.ejpb.2007.04.016	PROPN
admet-1474	468	3	https://doi.org/10.1155/2018/9825363	https://doi.org/10.1155/2018/9825363	NOUN
admet-1474	468	4	admet	admet	PROPN
admet-1474	468	5	&	&	CCONJ
admet-1474	468	6	dmpk	dmpk	PROPN
admet-1474	468	7	11(1	11(1	NUM
admet-1474	468	8	)	)	PUNCT
admet-1474	468	9	(	(	PUNCT
admet-1474	468	10	2023	2023	NUM
admet-1474	468	11	)	)	PUNCT
admet-1474	468	12	97	97	NUM
admet-1474	468	13	-	-	SYM
admet-1474	468	14	115	115	NUM
admet-1474	468	15	evaluation	evaluation	NOUN
admet-1474	468	16	of	of	ADP
admet-1474	468	17	re	re	ADJ
admet-1474	468	18	-	-	ADJ
admet-1474	468	19	formulated	formulate	VERB
admet-1474	468	20	levodopa	levodopa	NOUN
admet-1474	468	21	and	and	CCONJ
admet-1474	468	22	carbidopa	carbidopa	NOUN
admet-1474	468	23	doi	doi	NOUN
admet-1474	468	24	:	:	PUNCT
admet-1474	468	25	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	NOUN
admet-1474	468	26	115	115	NUM
admet-1474	469	1	[	[	X
admet-1474	469	2	49	49	NUM
admet-1474	469	3	]	]	X
admet-1474	469	4	d.g	d.g	PROPN
admet-1474	469	5	.	.	PROPN
admet-1474	469	6	yu	yu	PROPN
admet-1474	469	7	,	,	PUNCT
admet-1474	469	8	x.	x.	PROPN
admet-1474	469	9	wang	wang	PROPN
admet-1474	469	10	,	,	PUNCT
admet-1474	469	11	x.y	x.y	PROPN
admet-1474	469	12	.	.	PROPN
admet-1474	469	13	li	li	PROPN
admet-1474	469	14	,	,	PUNCT
admet-1474	469	15	w.	w.	PROPN
admet-1474	469	16	chian	chian	PROPN
admet-1474	469	17	,	,	PUNCT
admet-1474	469	18	y.	y.	PROPN
admet-1474	469	19	li	li	PROPN
admet-1474	469	20	,	,	PUNCT
admet-1474	469	21	y.z	y.z	PROPN
admet-1474	469	22	.	.	PROPN
admet-1474	469	23	liao	liao	PROPN
admet-1474	469	24	.	.	PROPN
admet-1474	470	1	electrospun	electrospun	PROPN
admet-1474	470	2	biphasic	biphasic	ADJ
admet-1474	470	3	drug	drug	NOUN
admet-1474	470	4	release	release	NOUN
admet-1474	470	5	polyvinylpyrrolidone	polyvinylpyrrolidone	PROPN
admet-1474	470	6	/	/	SYM
admet-1474	470	7	ethyl	ethyl	PROPN
admet-1474	470	8	cellulose	cellulose	NOUN
admet-1474	470	9	core	core	NOUN
admet-1474	470	10	/	/	SYM
admet-1474	470	11	sheath	sheath	NOUN
admet-1474	470	12	nanofibers	nanofiber	NOUN
admet-1474	470	13	.	.	PUNCT
admet-1474	471	1	acta	acta	PROPN
admet-1474	471	2	biomaterialia	biomaterialia	PROPN
admet-1474	471	3	9	9	NUM
admet-1474	471	4	(	(	PUNCT
admet-1474	471	5	2013	2013	NUM
admet-1474	471	6	)	)	PUNCT
admet-1474	471	7	5665	5665	NUM
admet-1474	471	8	–	–	PUNCT
admet-1474	471	9	5672	5672	NUM
admet-1474	471	10	.	.	PUNCT
admet-1474	472	1	https://doi.org/10.1016/j.actbio.2012.10.021	https://doi.org/10.1016/j.actbio.2012.10.021	PROPN
admet-1474	472	2	.	.	PUNCT
admet-1474	473	1	[	[	X
admet-1474	473	2	50	50	NUM
admet-1474	473	3	]	]	X
admet-1474	473	4	c.w	c.w	PROPN
admet-1474	473	5	.	.	PROPN
admet-1474	473	6	olanow	olanow	PROPN
admet-1474	473	7	,	,	PUNCT
admet-1474	473	8	j.a	j.a	PROPN
admet-1474	473	9	.	.	PROPN
admet-1474	473	10	obeso	obeso	PROPN
admet-1474	473	11	,	,	PUNCT
admet-1474	473	12	f.	f.	PROPN
admet-1474	473	13	stocchi	stocchi	PROPN
admet-1474	473	14	.	.	PUNCT
admet-1474	474	1	continuous	continuous	ADJ
admet-1474	474	2	dopamine	dopamine	NOUN
admet-1474	474	3	-	-	PUNCT
admet-1474	474	4	receptor	receptor	NOUN
admet-1474	474	5	treatment	treatment	NOUN
admet-1474	474	6	of	of	ADP
admet-1474	474	7	parkinson	parkinson	NOUN
admet-1474	474	8	’s	’s	PART
admet-1474	474	9	disease	disease	NOUN
admet-1474	474	10	:	:	PUNCT
admet-1474	474	11	scientific	scientific	ADJ
admet-1474	474	12	rationale	rationale	NOUN
admet-1474	474	13	and	and	CCONJ
admet-1474	474	14	clinical	clinical	ADJ
admet-1474	474	15	implications	implication	NOUN
admet-1474	474	16	.	.	PUNCT
admet-1474	475	1	lancet	lancet	NOUN
admet-1474	475	2	neurology	neurology	NOUN
admet-1474	475	3	5	5	NUM
admet-1474	475	4	(	(	PUNCT
admet-1474	475	5	2006	2006	NUM
admet-1474	475	6	)	)	PUNCT
admet-1474	475	7	677–687	677–687	NUM
admet-1474	475	8	.	.	PUNCT
admet-1474	476	1	https://doi.org/10.1016/s1474-4422(06)70521-x	https://doi.org/10.1016/s1474-4422(06)70521-x	NOUN
admet-1474	476	2	.	.	PUNCT
admet-1474	477	1	[	[	X
admet-1474	477	2	51	51	NUM
admet-1474	477	3	]	]	PUNCT
admet-1474	477	4	s.-p	s.-p	PROPN
admet-1474	477	5	.	.	PUNCT
admet-1474	478	1	khor	khor	PROPN
admet-1474	478	2	,	,	PUNCT
admet-1474	478	3	a.	a.	PROPN
admet-1474	478	4	hsu	hsu	PROPN
admet-1474	478	5	.	.	PUNCT
admet-1474	479	1	the	the	DET
admet-1474	479	2	pharmacokinetics	pharmacokinetic	NOUN
admet-1474	479	3	and	and	CCONJ
admet-1474	479	4	pharmacodynamics	pharmacodynamic	NOUN
admet-1474	479	5	of	of	ADP
admet-1474	479	6	levodopa	levodopa	NOUN
admet-1474	479	7	in	in	ADP
admet-1474	479	8	the	the	DET
admet-1474	479	9	treatment	treatment	NOUN
admet-1474	479	10	of	of	ADP
admet-1474	479	11	parkinsons	parkinson	NOUN
admet-1474	479	12	disease	disease	NOUN
admet-1474	479	13	.	.	PUNCT
admet-1474	480	1	current	current	ADJ
admet-1474	480	2	clinical	clinical	ADJ
admet-1474	480	3	pharmacology	pharmacology	NOUN
admet-1474	480	4	2	2	NUM
admet-1474	480	5	(	(	PUNCT
admet-1474	480	6	2008	2008	NUM
admet-1474	480	7	)	)	PUNCT
admet-1474	480	8	234–243	234–243	NUM
admet-1474	480	9	.	.	PUNCT
admet-1474	481	1	https://doi.org/10.2174/157488407781668802	https://doi.org/10.2174/157488407781668802	VERB
admet-1474	481	2	.	.	PUNCT
admet-1474	482	1	[	[	X
admet-1474	482	2	52	52	NUM
admet-1474	482	3	]	]	X
admet-1474	482	4	b.s	b.s	PROPN
admet-1474	482	5	.	.	PROPN
admet-1474	482	6	connolly	connolly	PROPN
admet-1474	482	7	,	,	PUNCT
admet-1474	482	8	a.e	a.e	PROPN
admet-1474	482	9	.	.	PROPN
admet-1474	482	10	lang	lang	PROPN
admet-1474	482	11	.	.	PUNCT
admet-1474	483	1	pharmacological	pharmacological	ADJ
admet-1474	483	2	treatment	treatment	NOUN
admet-1474	483	3	of	of	ADP
admet-1474	483	4	parkinson	parkinson	NOUN
admet-1474	483	5	disease	disease	NOUN
admet-1474	483	6	:	:	PUNCT
admet-1474	483	7	a	a	DET
admet-1474	483	8	review	review	NOUN
admet-1474	483	9	.	.	PUNCT
admet-1474	484	1	jama	jama	PROPN
admet-1474	484	2	journal	journal	PROPN
admet-1474	484	3	of	of	ADP
admet-1474	484	4	the	the	DET
admet-1474	484	5	american	american	PROPN
admet-1474	484	6	medical	medical	PROPN
admet-1474	484	7	association	association	PROPN
admet-1474	484	8	311	311	NUM
admet-1474	484	9	(	(	PUNCT
admet-1474	484	10	2014	2014	NUM
admet-1474	484	11	)	)	PUNCT
admet-1474	484	12	1670–1683	1670–1683	NUM
admet-1474	484	13	.	.	PUNCT
admet-1474	485	1	https://doi.org/10.1001/jama.2014.3654	https://doi.org/10.1001/jama.2014.3654	PROPN
admet-1474	485	2	.	.	PUNCT
admet-1474	486	1	[	[	X
admet-1474	486	2	53	53	NUM
admet-1474	486	3	]	]	PUNCT
admet-1474	486	4	j.	j.	PROPN
admet-1474	486	5	margolesky	margolesky	PROPN
admet-1474	486	6	,	,	PUNCT
admet-1474	486	7	c.	c.	PROPN
admet-1474	486	8	singer	singer	PROPN
admet-1474	486	9	.	.	PUNCT
admet-1474	486	10	extended	extend	VERB
admet-1474	486	11	-	-	PUNCT
admet-1474	486	12	release	release	NOUN
admet-1474	486	13	oral	oral	ADJ
admet-1474	486	14	capsule	capsule	NOUN
admet-1474	486	15	of	of	ADP
admet-1474	486	16	carbidopa	carbidopa	NOUN
admet-1474	486	17	-	-	NOUN
admet-1474	486	18	levodopa	levodopa	NOUN
admet-1474	486	19	in	in	ADP
admet-1474	486	20	parkinson	parkinson	NOUN
admet-1474	486	21	disease	disease	NOUN
admet-1474	486	22	.	.	PUNCT
admet-1474	487	1	therapeutic	therapeutic	ADJ
admet-1474	487	2	advances	advance	NOUN
admet-1474	487	3	in	in	ADP
admet-1474	487	4	neurological	neurological	ADJ
admet-1474	487	5	disorders	disorder	NOUN
admet-1474	487	6	11	11	NUM
admet-1474	487	7	(	(	PUNCT
admet-1474	487	8	2018	2018	NUM
admet-1474	487	9	)	)	PUNCT
admet-1474	487	10	.	.	PUNCT
admet-1474	488	1	https://doi.org/10.1177/1756285617737728	https://doi.org/10.1177/1756285617737728	NOUN
admet-1474	488	2	.	.	PUNCT
admet-1474	489	1	[	[	X
admet-1474	489	2	54	54	NUM
admet-1474	489	3	]	]	X
admet-1474	489	4	r.a	r.a	PROPN
admet-1474	489	5	.	.	PROPN
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admet-1474	489	7	,	,	PUNCT
admet-1474	489	8	g.	g.	PROPN
admet-1474	489	9	banisadr	banisadr	PROPN
admet-1474	489	10	,	,	PUNCT
admet-1474	489	11	k.	k.	PROPN
admet-1474	489	12	vuong	vuong	PROPN
admet-1474	489	13	,	,	PUNCT
admet-1474	489	14	d.	d.	PROPN
admet-1474	489	15	freilich	freilich	PROPN
admet-1474	489	16	,	,	PUNCT
admet-1474	489	17	s.	s.	PROPN
admet-1474	489	18	fisher	fisher	PROPN
admet-1474	489	19	,	,	PUNCT
admet-1474	489	20	r.	r.	PROPN
admet-1474	489	21	d’souza	d’souza	PROPN
admet-1474	489	22	.	.	PUNCT
admet-1474	490	1	real	real	ADJ
admet-1474	490	2	-	-	PUNCT
admet-1474	490	3	world	world	NOUN
admet-1474	490	4	experience	experience	NOUN
admet-1474	490	5	with	with	ADP
admet-1474	490	6	carbidopa	carbidopa	NOUN
admet-1474	490	7	-	-	PUNCT
admet-1474	490	8	levodopa	levodopa	NOUN
admet-1474	490	9	extended	extend	VERB
admet-1474	490	10	-	-	PUNCT
admet-1474	490	11	release	release	NOUN
admet-1474	490	12	capsules	capsule	NOUN
admet-1474	490	13	(	(	PUNCT
admet-1474	490	14	rytary	rytary	ADJ
admet-1474	490	15	®	®	NOUN
admet-1474	490	16	):	):	PUNCT
admet-1474	490	17	results	result	NOUN
admet-1474	490	18	of	of	ADP
admet-1474	490	19	a	a	DET
admet-1474	490	20	nationwide	nationwide	ADJ
admet-1474	490	21	dose	dose	NOUN
admet-1474	490	22	conversion	conversion	NOUN
admet-1474	490	23	survey	survey	NOUN
admet-1474	490	24	.	.	PUNCT
admet-1474	491	1	parkinson	parkinson	NOUN
admet-1474	491	2	’s	’s	PART
admet-1474	491	3	disease	disease	NOUN
admet-1474	491	4	2021	2021	NUM
admet-1474	491	5	(	(	PUNCT
admet-1474	491	6	2021	2021	NUM
admet-1474	491	7	)	)	PUNCT
admet-1474	491	8	.	.	PUNCT
admet-1474	492	1	https://doi.org/10.1155/2021/6638088	https://doi.org/10.1155/2021/6638088	PROPN
admet-1474	492	2	.	.	PUNCT
admet-1474	493	1	[	[	X
admet-1474	493	2	55	55	NUM
admet-1474	493	3	]	]	X
admet-1474	493	4	j.t	j.t	PROPN
admet-1474	493	5	.	.	PROPN
admet-1474	493	6	dipiro	dipiro	PROPN
admet-1474	493	7	,	,	PUNCT
admet-1474	493	8	w.j	w.j	PROPN
admet-1474	493	9	.	.	PROPN
admet-1474	493	10	spruill	spruill	PROPN
admet-1474	493	11	,	,	PUNCT
admet-1474	493	12	w.e	w.e	PROPN
admet-1474	493	13	.	.	PROPN
admet-1474	493	14	wade	wade	PROPN
admet-1474	493	15	,	,	PUNCT
admet-1474	493	16	r.a	r.a	PROPN
admet-1474	493	17	.	.	PROPN
admet-1474	493	18	blouin	blouin	PROPN
admet-1474	493	19	,	,	PUNCT
admet-1474	493	20	j.m	j.m	PROPN
admet-1474	493	21	.	.	PROPN
admet-1474	493	22	pruemer	pruemer	PROPN
admet-1474	493	23	,	,	PUNCT
admet-1474	493	24	m.p	m.p	PROPN
admet-1474	493	25	.	.	PROPN
admet-1474	493	26	ducharme	ducharme	PROPN
admet-1474	493	27	.	.	PUNCT
admet-1474	494	1	concepts	concept	NOUN
admet-1474	494	2	in	in	ADP
admet-1474	494	3	clinical	clinical	ADJ
admet-1474	494	4	pharmacokinetics	pharmacokinetic	NOUN
admet-1474	494	5	,	,	PUNCT
admet-1474	494	6	4th	4th	ADJ
admet-1474	494	7	edition	edition	NOUN
admet-1474	494	8	.	.	PUNCT
admet-1474	495	1	annals	annal	NOUN
admet-1474	495	2	of	of	ADP
admet-1474	495	3	pharmacotherapy	pharmacotherapy	NOUN
admet-1474	495	4	40	40	NUM
admet-1474	495	5	(	(	PUNCT
admet-1474	495	6	2006	2006	NUM
admet-1474	495	7	)	)	PUNCT
admet-1474	495	8	1479–1479	1479–1479	NUM
admet-1474	495	9	.	.	PUNCT
admet-1474	496	1	https://doi.org/10.1345/aph.1h081	https://doi.org/10.1345/aph.1h081	X
admet-1474	496	2	.	.	PUNCT
admet-1474	497	1	[	[	X
admet-1474	497	2	56	56	NUM
admet-1474	497	3	]	]	X
admet-1474	497	4	c.	c.	PROPN
admet-1474	497	5	saikia	saikia	PROPN
admet-1474	497	6	,	,	PUNCT
admet-1474	497	7	p.	p.	PROPN
admet-1474	497	8	gogoi	gogoi	PROPN
admet-1474	497	9	.	.	PUNCT
admet-1474	498	1	chitosan	chitosan	NOUN
admet-1474	498	2	:	:	PUNCT
admet-1474	498	3	a	a	DET
admet-1474	498	4	promising	promising	ADJ
admet-1474	498	5	biopolymer	biopolymer	NOUN
admet-1474	498	6	in	in	ADP
admet-1474	498	7	drug	drug	NOUN
admet-1474	498	8	delivery	delivery	NOUN
admet-1474	498	9	applications	application	NOUN
admet-1474	498	10	.	.	PUNCT
admet-1474	499	1	journal	journal	NOUN
admet-1474	499	2	of	of	ADP
admet-1474	499	3	molecular	molecular	ADJ
admet-1474	499	4	and	and	CCONJ
admet-1474	499	5	genetic	genetic	ADJ
admet-1474	499	6	medicine	medicine	NOUN
admet-1474	499	7	s4	s4	NOUN
admet-1474	499	8	(	(	PUNCT
admet-1474	499	9	2015	2015	NUM
admet-1474	499	10	)	)	PUNCT
admet-1474	499	11	.	.	PUNCT
admet-1474	500	1	https://doi.org/10.4172/1747-0862.s4-006	https://doi.org/10.4172/1747-0862.s4-006	NOUN
admet-1474	500	2	.	.	PUNCT
admet-1474	501	1	[	[	X
admet-1474	501	2	57	57	NUM
admet-1474	501	3	]	]	PUNCT
admet-1474	501	4	a.	a.	NOUN
admet-1474	501	5	bernkop	bernkop	PROPN
admet-1474	501	6	-	-	PUNCT
admet-1474	501	7	schnürch	schnürch	NOUN
admet-1474	501	8	,	,	PUNCT
admet-1474	501	9	s.	s.	PROPN
admet-1474	501	10	dünnhaupt	dünnhaupt	PROPN
admet-1474	501	11	.	.	PUNCT
admet-1474	502	1	chitosan	chitosan	NOUN
admet-1474	502	2	-	-	PUNCT
admet-1474	502	3	based	base	VERB
admet-1474	502	4	drug	drug	NOUN
admet-1474	502	5	delivery	delivery	NOUN
admet-1474	502	6	systems	system	NOUN
admet-1474	502	7	.	.	PUNCT
admet-1474	503	1	european	european	ADJ
admet-1474	503	2	journal	journal	PROPN
admet-1474	503	3	of	of	ADP
admet-1474	503	4	pharmaceutics	pharmaceutic	NOUN
admet-1474	503	5	and	and	CCONJ
admet-1474	503	6	biopharmaceutics	biopharmaceutic	NOUN
admet-1474	503	7	81	81	NUM
admet-1474	503	8	(	(	PUNCT
admet-1474	503	9	2012	2012	NUM
admet-1474	503	10	)	)	PUNCT
admet-1474	503	11	463–469	463–469	NUM
admet-1474	503	12	.	.	PUNCT
admet-1474	504	1	https://doi.org/10.1016/j.ejpb.2012.04.007	https://doi.org/10.1016/j.ejpb.2012.04.007	ADJ
admet-1474	504	2	.	.	PUNCT
admet-1474	505	1	[	[	X
admet-1474	505	2	58	58	NUM
admet-1474	505	3	]	]	X
admet-1474	505	4	g.m	g.m	PROPN
admet-1474	505	5	.	.	PROPN
admet-1474	505	6	soliman	soliman	PROPN
admet-1474	505	7	,	,	PUNCT
admet-1474	505	8	y.l	y.l	PROPN
admet-1474	505	9	.	.	PROPN
admet-1474	505	10	zhang	zhang	PROPN
admet-1474	505	11	,	,	PUNCT
admet-1474	505	12	g.	g.	PROPN
admet-1474	505	13	merle	merle	PROPN
admet-1474	505	14	,	,	PUNCT
admet-1474	505	15	m.	m.	NOUN
admet-1474	505	16	cerruti	cerruti	PROPN
admet-1474	505	17	,	,	PUNCT
admet-1474	505	18	j.	j.	PROPN
admet-1474	505	19	barralet	barralet	PROPN
admet-1474	505	20	.	.	PUNCT
admet-1474	506	1	hydrocaffeic	hydrocaffeic	ADJ
admet-1474	506	2	acid	acid	NOUN
admet-1474	506	3	-	-	PUNCT
admet-1474	506	4	chitosan	chitosan	NOUN
admet-1474	506	5	nanoparticles	nanoparticle	NOUN
admet-1474	506	6	with	with	ADP
admet-1474	506	7	enhanced	enhanced	ADJ
admet-1474	506	8	stability	stability	NOUN
admet-1474	506	9	,	,	PUNCT
admet-1474	506	10	mucoadhesion	mucoadhesion	NOUN
admet-1474	506	11	and	and	CCONJ
admet-1474	506	12	permeation	permeation	NOUN
admet-1474	506	13	properties	property	NOUN
admet-1474	506	14	.	.	PUNCT
admet-1474	507	1	european	european	ADJ
admet-1474	507	2	journal	journal	PROPN
admet-1474	507	3	of	of	ADP
admet-1474	507	4	pharmaceutics	pharmaceutic	NOUN
admet-1474	507	5	and	and	CCONJ
admet-1474	507	6	biopharmaceutics	biopharmaceutic	NOUN
admet-1474	507	7	88	88	NUM
admet-1474	507	8	(	(	PUNCT
admet-1474	507	9	2014	2014	NUM
admet-1474	507	10	)	)	PUNCT
admet-1474	507	11	1026–1037	1026–1037	NUM
admet-1474	507	12	.	.	PUNCT
admet-1474	507	13	https://doi.org/10.1016/j.ejpb.2014.09.003	https://doi.org/10.1016/j.ejpb.2014.09.003	NOUN
admet-1474	507	14	.	.	PUNCT
admet-1474	508	1	[	[	X
admet-1474	508	2	59	59	NUM
admet-1474	508	3	]	]	PUNCT
admet-1474	508	4	a.	a.	NOUN
admet-1474	508	5	kaur	kaur	PROPN
admet-1474	508	6	,	,	PUNCT
admet-1474	508	7	g.	g.	PROPN
admet-1474	508	8	kaur	kaur	PROPN
admet-1474	508	9	.	.	PUNCT
admet-1474	509	1	mucoadhesive	mucoadhesive	ADJ
admet-1474	509	2	buccal	buccal	ADJ
admet-1474	509	3	patches	patch	NOUN
admet-1474	509	4	based	base	VERB
admet-1474	509	5	on	on	ADP
admet-1474	509	6	interpolymer	interpolymer	ADJ
admet-1474	509	7	complexes	complex	NOUN
admet-1474	509	8	of	of	ADP
admet-1474	509	9	chitosanpectin	chitosanpectin	NOUN
admet-1474	509	10	for	for	ADP
admet-1474	509	11	delivery	delivery	NOUN
admet-1474	509	12	of	of	ADP
admet-1474	509	13	carvedilol	carvedilol	NOUN
admet-1474	509	14	.	.	PUNCT
admet-1474	510	1	saudi	saudi	ADJ
admet-1474	510	2	pharmaceutical	pharmaceutical	PROPN
admet-1474	510	3	journal	journal	PROPN
admet-1474	510	4	20	20	NUM
admet-1474	510	5	(	(	PUNCT
admet-1474	510	6	2012	2012	NUM
admet-1474	510	7	)	)	PUNCT
admet-1474	510	8	21–27	21–27	NUM
admet-1474	510	9	.	.	PUNCT
admet-1474	511	1	https://doi.org/10.1016/j.jsps.2011.04.005	https://doi.org/10.1016/j.jsps.2011.04.005	PROPN
admet-1474	511	2	.	.	PUNCT
admet-1474	512	1	[	[	X
admet-1474	512	2	60	60	NUM
admet-1474	512	3	]	]	X
admet-1474	512	4	g.a	g.a	PROPN
admet-1474	512	5	.	.	PROPN
admet-1474	512	6	morris	morris	PROPN
admet-1474	512	7	,	,	PUNCT
admet-1474	512	8	s.m	s.m	PROPN
admet-1474	512	9	.	.	PROPN
admet-1474	512	10	kök	kök	PROPN
admet-1474	512	11	,	,	PUNCT
admet-1474	512	12	s.e	s.e	PROPN
admet-1474	512	13	.	.	PROPN
admet-1474	512	14	harding	harding	PROPN
admet-1474	512	15	,	,	PUNCT
admet-1474	512	16	g.g	g.g	PROPN
admet-1474	512	17	.	.	PROPN
admet-1474	512	18	adams	adams	PROPN
admet-1474	512	19	.	.	PROPN
admet-1474	513	1	polysaccharide	polysaccharide	NOUN
admet-1474	513	2	drug	drug	NOUN
admet-1474	513	3	delivery	delivery	NOUN
admet-1474	513	4	systems	system	NOUN
admet-1474	513	5	based	base	VERB
admet-1474	513	6	on	on	ADP
admet-1474	513	7	pectin	pectin	NOUN
admet-1474	513	8	and	and	CCONJ
admet-1474	513	9	chitosan	chitosan	NOUN
admet-1474	513	10	.	.	PUNCT
admet-1474	514	1	biotechnology	biotechnology	NOUN
admet-1474	514	2	and	and	CCONJ
admet-1474	514	3	genetic	genetic	ADJ
admet-1474	514	4	engineering	engineering	NOUN
admet-1474	514	5	reviews	review	NOUN
admet-1474	514	6	27	27	NUM
admet-1474	514	7	(	(	PUNCT
admet-1474	514	8	2010	2010	NUM
admet-1474	514	9	)	)	PUNCT
admet-1474	514	10	257–284	257–284	NUM
admet-1474	514	11	.	.	PUNCT
admet-1474	515	1	https://doi.org/10.1080/02648725.2010.10648153	https://doi.org/10.1080/02648725.2010.10648153	PROPN
admet-1474	515	2	.	.	PUNCT
admet-1474	516	1	[	[	X
admet-1474	516	2	61	61	NUM
admet-1474	516	3	]	]	PUNCT
admet-1474	516	4	h.	h.	PROPN
admet-1474	516	5	nettey	nettey	PROPN
admet-1474	516	6	,	,	PUNCT
admet-1474	516	7	g.l	g.l	PROPN
admet-1474	516	8	.	.	PROPN
admet-1474	516	9	allotey	allotey	PROPN
admet-1474	516	10	-	-	PUNCT
admet-1474	516	11	babington	babington	PROPN
admet-1474	516	12	,	,	PUNCT
admet-1474	516	13	i.	i.	PROPN
admet-1474	516	14	somuah	somuah	PROPN
admet-1474	516	15	,	,	PUNCT
admet-1474	516	16	n.b	n.b	PROPN
admet-1474	516	17	.	.	PROPN
admet-1474	516	18	banga	banga	PROPN
admet-1474	516	19	,	,	PUNCT
admet-1474	516	20	b.	b.	PROPN
admet-1474	516	21	afrane	afrane	PROPN
admet-1474	516	22	,	,	PUNCT
admet-1474	516	23	s.k	s.k	PROPN
admet-1474	516	24	.	.	PROPN
admet-1474	516	25	amponsah	amponsah	PROPN
admet-1474	516	26	,	,	PUNCT
admet-1474	516	27	h.	h.	PROPN
admet-1474	516	28	annor	annor	PROPN
admet-1474	516	29	,	,	PUNCT
admet-1474	516	30	h.	h.	PROPN
admet-1474	516	31	darko	darko	PROPN
admet-1474	516	32	,	,	PUNCT
admet-1474	516	33	k.	k.	PROPN
admet-1474	516	34	hanson	hanson	PROPN
admet-1474	516	35	,	,	PUNCT
admet-1474	516	36	a.	a.	PROPN
admet-1474	516	37	aidoo	aidoo	PROPN
admet-1474	516	38	,	,	PUNCT
admet-1474	516	39	mn	mn	PROPN
admet-1474	516	40	broni	broni	NOUN
admet-1474	516	41	,	,	PUNCT
admet-1474	516	42	c.	c.	PROPN
admet-1474	516	43	sasu	sasu	PROPN
admet-1474	516	44	,	,	PUNCT
admet-1474	516	45	a.	a.	NOUN
admet-1474	516	46	nyarko	nyarko	NOUN
admet-1474	516	47	.	.	PUNCT
admet-1474	517	1	assessment	assessment	NOUN
admet-1474	517	2	of	of	ADP
admet-1474	517	3	formulated	formulate	VERB
admet-1474	517	4	amodiaquine	amodiaquine	PROPN
admet-1474	517	5	microparticles	microparticle	NOUN
admet-1474	517	6	in	in	ADP
admet-1474	517	7	leishmania	leishmania	NOUN
admet-1474	517	8	donovani	donovani	VERB
admet-1474	517	9	infected	infected	ADJ
admet-1474	517	10	rats	rat	NOUN
admet-1474	517	11	.	.	PUNCT
admet-1474	518	1	journal	journal	NOUN
admet-1474	518	2	of	of	ADP
admet-1474	518	3	microencapsulation	microencapsulation	NOUN
admet-1474	518	4	34	34	NUM
admet-1474	518	5	(	(	PUNCT
admet-1474	518	6	2017	2017	NUM
admet-1474	518	7	)	)	PUNCT
admet-1474	518	8	2128	2128	NUM
admet-1474	518	9	.	.	PUNCT
admet-1474	519	1	https://doi.org/10.1080/02652048.2017.1280094	https://doi.org/10.1080/02652048.2017.1280094	X
admet-1474	519	2	.	.	PUNCT
admet-1474	520	1	[	[	X
admet-1474	520	2	62	62	NUM
admet-1474	520	3	]	]	SYM
admet-1474	520	4	l.n.m	l.n.m	NOUN
admet-1474	520	5	.	.	PUNCT
admet-1474	520	6	ribeiro	ribeiro	PROPN
admet-1474	520	7	,	,	PUNCT
admet-1474	520	8	a.c.s	a.c.s	PROPN
admet-1474	520	9	.	.	PROPN
admet-1474	520	10	alcântara	alcântara	PROPN
admet-1474	520	11	,	,	PUNCT
admet-1474	520	12	m.	m.	NOUN
admet-1474	520	13	darder	darder	NOUN
admet-1474	520	14	,	,	PUNCT
admet-1474	520	15	p.	p.	PROPN
admet-1474	520	16	aranda	aranda	PROPN
admet-1474	520	17	,	,	PUNCT
admet-1474	520	18	f.m	f.m	PROPN
admet-1474	520	19	.	.	PROPN
admet-1474	520	20	araújo	araújo	PROPN
admet-1474	520	21	-	-	PUNCT
admet-1474	520	22	moreira	moreira	PROPN
admet-1474	520	23	,	,	PUNCT
admet-1474	520	24	e.	e.	PROPN
admet-1474	520	25	ruiz	ruiz	PROPN
admet-1474	520	26	-	-	PUNCT
admet-1474	520	27	hitzky	hitzky	NOUN
admet-1474	520	28	.	.	PUNCT
admet-1474	521	1	pectincoated	pectincoate	VERB
admet-1474	521	2	chitosan	chitosan	PROPN
admet-1474	521	3	-	-	PUNCT
admet-1474	521	4	ldh	ldh	ADJ
admet-1474	521	5	bionanocomposite	bionanocomposite	ADJ
admet-1474	521	6	beads	bead	NOUN
admet-1474	521	7	as	as	ADP
admet-1474	521	8	potential	potential	ADJ
admet-1474	521	9	systems	system	NOUN
admet-1474	521	10	for	for	ADP
admet-1474	521	11	colon	colon	NOUN
admet-1474	521	12	-	-	PUNCT
admet-1474	521	13	targeted	target	VERB
admet-1474	521	14	drug	drug	NOUN
admet-1474	521	15	delivery	delivery	NOUN
admet-1474	521	16	.	.	PUNCT
admet-1474	522	1	international	international	ADJ
admet-1474	522	2	journal	journal	PROPN
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admet-1474	522	4	pharmaceutics	pharmaceutic	NOUN
admet-1474	522	5	463	463	NUM
admet-1474	522	6	(	(	PUNCT
admet-1474	522	7	2014	2014	NUM
admet-1474	522	8	)	)	PUNCT
admet-1474	522	9	1–9	1–9	NOUN
admet-1474	522	10	.	.	PUNCT
admet-1474	522	11	https://doi.org/10.1016/j.ijpharm.2013.12.035	https://doi.org/10.1016/j.ijpharm.2013.12.035	PROPN
admet-1474	522	12	.	.	PUNCT
admet-1474	523	1	©	©	NOUN
admet-1474	523	2	2022	2022	NUM
admet-1474	523	3	by	by	ADP
admet-1474	523	4	the	the	DET
admet-1474	523	5	authors	author	NOUN
admet-1474	523	6	;	;	PUNCT
admet-1474	523	7	licensee	licensee	PROPN
admet-1474	523	8	iapc	iapc	PROPN
admet-1474	523	9	,	,	PUNCT
admet-1474	523	10	zagreb	zagreb	PROPN
admet-1474	523	11	,	,	PUNCT
admet-1474	523	12	croatia	croatia	PROPN
admet-1474	523	13	.	.	PUNCT
admet-1474	524	1	this	this	DET
admet-1474	524	2	article	article	NOUN
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admet-1474	524	4	an	an	DET
admet-1474	524	5	open	open	ADJ
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admet-1474	524	7	access	access	NOUN
admet-1474	524	8	article	article	NOUN
admet-1474	524	9	distributed	distribute	VERB
admet-1474	524	10	under	under	ADP
admet-1474	524	11	the	the	DET
admet-1474	524	12	terms	term	NOUN
admet-1474	524	13	and	and	CCONJ
admet-1474	524	14	conditions	condition	NOUN
admet-1474	524	15	of	of	ADP
admet-1474	524	16	the	the	DET
admet-1474	524	17	creative	creative	ADJ
admet-1474	524	18	commons	common	NOUN
admet-1474	524	19	attribution	attribution	NOUN
admet-1474	524	20	license	license	NOUN
admet-1474	524	21	(	(	PUNCT
admet-1474	524	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-1474	524	23	)	)	PUNCT
admet-1474	524	24	http://dx.doi.org/10.5599/admet.1474	http://dx.doi.org/10.5599/admet.1474	PROPN
admet-1474	524	25	https://doi.org/10.1016/j.actbio.2012.10.021	https://doi.org/10.1016/j.actbio.2012.10.021	PROPN
admet-1474	524	26	https://doi.org/10.1016/s1474-4422(06)70521-x	https://doi.org/10.1016/s1474-4422(06)70521-x	PROPN
admet-1474	524	27	https://doi.org/10.2174/157488407781668802	https://doi.org/10.2174/157488407781668802	PROPN
admet-1474	524	28	https://doi.org/10.2174/157488407781668802	https://doi.org/10.2174/157488407781668802	NOUN
admet-1474	524	29	https://doi.org/10.1001/jama.%1f2014.3654	https://doi.org/10.1001/jama.%1f2014.3654	PROPN
admet-1474	524	30	https://doi.org/10.1001/jama.%1f2014.3654	https://doi.org/10.1001/jama.%1f2014.3654	ADJ
admet-1474	524	31	https://doi.org/10.1177/17562856%1f17737728	https://doi.org/10.1177/17562856%1f17737728	NOUN
admet-1474	524	32	https://doi.org/10.1177/17562856%1f17737728	https://doi.org/10.1177/17562856%1f17737728	NOUN
admet-1474	524	33	https://doi.org/10.1155/2021/6638088	https://doi.org/10.1155/2021/6638088	PROPN
admet-1474	524	34	https://doi.org/10.1345/aph.1h081	https://doi.org/10.1345/aph.1h081	VERB
admet-1474	524	35	https://doi.org/10.4172/1747-0862.s4-006	https://doi.org/10.4172/1747-0862.s4-006	ADJ
admet-1474	524	36	https://doi.org/10.1016/j.ejpb.2012.04.007	https://doi.org/10.1016/j.ejpb.2012.04.007	ADJ
admet-1474	524	37	https://doi.org/10.1016/j.ejpb.2012.04.007	https://doi.org/10.1016/j.ejpb.2012.04.007	VERB
admet-1474	524	38	https://doi.org/10.1016/j.ejpb.2014.09.003	https://doi.org/10.1016/j.ejpb.2014.09.003	NOUN
admet-1474	524	39	https://doi.org/10.1016/j.ejpb.2014.09.003	https://doi.org/10.1016/j.ejpb.2014.09.003	NOUN
admet-1474	524	40	https://doi.org/10.1016/j.jsps.2011.04.005	https://doi.org/10.1016/j.jsps.2011.04.005	PROPN
admet-1474	524	41	https://doi.org/10.1080/02648725.2010.10648153	https://doi.org/10.1080/02648725.2010.10648153	VERB
admet-1474	524	42	https://doi.org/10.1080/02652048.2017.1280094	https://doi.org/10.1080/02652048.2017.1280094	PROPN
admet-1474	524	43	https://doi.org/10.1016/j.ijpharm.2013.12.035	https://doi.org/10.1016/j.ijpharm.2013.12.035	VERB
admet-1474	524	44	https://doi.org/10.1016/j.ijpharm.2013.12.035	https://doi.org/10.1016/j.ijpharm.2013.12.035	NOUN
admet-1474	524	45	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN